format-version: 1.2 data-version: releases/2024-03-06 date: 21:07:2015 00:00 saved-by: anne.morgat@isb-sib.ch synonymtypedef: FORMULA "FORMULA" synonymtypedef: InChI "InChI" default-namespace: unipathway_ontology remark: UniPathway Release 2015_03 ontology: upa [Term] id: BFO:0000002 name: continuant def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." [] disjoint_from: BFO:0000003 ! occurrent [Term] id: BFO:0000003 name: occurrent def: "An entity that has temporal parts and that happens, unfolds or develops through time." [] [Term] id: BFO:0000004 name: independent continuant def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." [] is_a: BFO:0000002 ! continuant [Term] id: BFO:0000015 name: process def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." [] is_a: BFO:0000003 ! occurrent [Term] id: BFO:0000040 name: material entity def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." [] is_a: BFO:0000004 ! independent continuant [Term] id: GO:0003674 name: molecular_function is_a: BFO:0000015 ! process property_value: IAO:0000589 "molecular process" xsd:string [Term] id: GO:0003824 name: catalytic activity is_a: GO:0003674 ! molecular_function [Term] id: GO:0008150 name: biological_process is_a: BFO:0000015 ! process [Term] id: GO:0016301 name: kinase activity is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016740 name: transferase activity is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups is_a: GO:0016740 ! transferase activity [Term] id: UPa:UCR00000 name: reaction namespace: reaction def: "A chemical reaction involved in a UniPathway pathway." [] xref: GO:0003824 [Term] id: UPa:UCR00005 name: H(2)O + urea-1-carboxylate = 2 CO(2) + 2 NH(3) namespace: reaction xref: KEGG:R00005 "KEGG reaction" xref: METACYC:ALLOPHANATE-HYDROLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19032 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01010 {cardinality="1"} ! urea-1-carboxylate relationship: has_input_compound UPa:UPC01010 ! urea-1-carboxylate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: part_of UPa:UER00372 {cardinality="1", direction="LR", order="1"} ! CO(2) and NH(3) from urea (allophanate route): step 2/2 relationship: part_of UPa:UER00372 ! CO(2) and NH(3) from urea (allophanate route): step 2/2 [Term] id: UPa:UCR00010 name: H(2)O + alpha,alpha-trehalose = 2 D-glucose namespace: reaction xref: KEGG:R00010 "KEGG reaction" xref: METACYC:TREHALA-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20871 "Rhea reaction" xref: RHEA:32678 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01083 {cardinality="1"} ! alpha,alpha-trehalose relationship: has_input_compound UPa:UPC01083 ! alpha,alpha-trehalose relationship: has_output_compound UPa:UPC00031 {cardinality="1"} ! D-glucose relationship: has_output_compound UPa:UPC00031 ! D-glucose relationship: part_of UPa:UER00535 {cardinality="1", direction="LR", order="1"} ! D-glucose from alpha,alpha-trehalose: step 1/1 relationship: part_of UPa:UER00535 ! D-glucose from alpha,alpha-trehalose: step 1/1 [Term] id: UPa:UCR00013 name: 2 glyoxylate = 2-hydroxy-3-oxopropanoate + CO(2) namespace: reaction xref: KEGG:R00013 "KEGG reaction" xref: METACYC:GLYOCARBOLIG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10139 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00048 ! glyoxylate relationship: has_input_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate relationship: has_output_compound UPa:UPC01146 {cardinality="1"} ! 2-hydroxy-3-oxopropanoate relationship: part_of UPa:UER00831 ! 3-phospho-D-glycerate from glycolate: step 2/4 relationship: part_of UPa:UER00831 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycolate: step 2/4 [Term] id: UPa:UCR00014 name: pyruvate + thiamine diphosphate = 2-hydroxyethyl-ThPP + CO(2) namespace: reaction xref: KEGG:R00014 "KEGG reaction" xref: METACYC:RXN-12583 "MetaCyc REACTION" {source="MetaCyc"} is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate relationship: has_input_compound UPa:UPC00068 ! thiamine diphosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC05125 {cardinality="1"} ! 2-hydroxyethyl-ThPP relationship: has_output_compound UPa:UPC05125 ! 2-hydroxyethyl-ThPP relationship: part_of UPa:UER00059 ! L-valine from pyruvate: step 1/4 relationship: part_of UPa:UER00059 {cardinality="1", direction="LR", order="1"} ! L-valine from pyruvate: step 1/4 [Term] id: UPa:UCR00021 name: 2 L-glutamate + 2 oxidized ferredoxin = 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced ferredoxin namespace: reaction xref: KEGG:R00021 "KEGG reaction" xref: METACYC:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12131 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00139 ! oxidized ferredoxin relationship: has_input_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00064 ! L-glutamine relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00138 ! reduced ferredoxin relationship: has_output_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin relationship: part_of UPa:UER00691 ! L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route): step 1/1 relationship: part_of UPa:UER00691 {cardinality="1", direction="RL", order="1"} ! L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route): step 1/1 [Term] id: UPa:UCR00036 name: 2 5-aminolevulinate = 2 H(2)O + porphobilinogen namespace: reaction xref: KEGG:R00036 "KEGG reaction" xref: METACYC:PORPHOBILSYNTH-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24067 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00430 ! 5-aminolevulinate relationship: has_input_compound UPa:UPC00430 {cardinality="1"} ! 5-aminolevulinate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00931 {cardinality="1"} ! porphobilinogen relationship: has_output_compound UPa:UPC00931 ! porphobilinogen relationship: part_of UPa:UER00318 ! coproporphyrinogen-III from 5-aminolevulinate: step 1/4 relationship: part_of UPa:UER00318 {cardinality="1", direction="LR", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate: step 1/4 [Term] id: UPa:UCR00066 name: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = 5-amino-6-(D-ribitylamino)uracil + riboflavin namespace: reaction xref: KEGG:R00066 "KEGG reaction" xref: METACYC:RIBOFLAVIN-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20775 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04332 {cardinality="1"} ! 6,7-dimethyl-8-(1-D-ribityl)lumazine relationship: has_input_compound UPa:UPC04332 ! 6,7-dimethyl-8-(1-D-ribityl)lumazine relationship: has_output_compound UPa:UPC00255 {cardinality="1"} ! riboflavin relationship: has_output_compound UPa:UPC00255 ! riboflavin relationship: has_output_compound UPa:UPC04732 ! 5-amino-6-(D-ribitylamino)uracil relationship: has_output_compound UPa:UPC04732 {cardinality="1"} ! 5-amino-6-(D-ribitylamino)uracil relationship: part_of UPa:UER00405 {cardinality="1", direction="LR", order="1"} ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2 relationship: part_of UPa:UER00405 ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2 [Term] id: UPa:UCR00084 name: H(2)O + 4 porphobilinogen = 4 NH(3) + hydroxymethylbilane namespace: reaction xref: KEGG:R00084 "KEGG reaction" xref: METACYC:OHMETHYLBILANESYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13188 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00931 {cardinality="1"} ! porphobilinogen relationship: has_input_compound UPa:UPC00931 ! porphobilinogen relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC01024 {cardinality="1"} ! hydroxymethylbilane relationship: has_output_compound UPa:UPC01024 ! hydroxymethylbilane relationship: part_of UPa:UER00319 ! coproporphyrinogen-III from 5-aminolevulinate: step 2/4 relationship: part_of UPa:UER00319 {cardinality="1", direction="LR", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate: step 2/4 [Term] id: UPa:UCR00093 name: 2 L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + L-glutamine + NADH namespace: reaction xref: KEGG:R00093 "KEGG reaction" xref: METACYC:GLUTAMATE-SYNTHASE-NADH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13756 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00064 ! L-glutamine relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00690 {cardinality="1", direction="RL", order="1"} ! L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1 relationship: part_of UPa:UER00690 ! L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1 [Term] id: UPa:UCR00114 name: 2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH namespace: reaction xref: KEGG:R00114 "KEGG reaction" xref: METACYC:GLUTAMATESYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15504 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00064 ! L-glutamine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:UER00689 {cardinality="1", direction="RL", order="1"} ! L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route): step 1/1 relationship: part_of UPa:UER00689 ! L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route): step 1/1 [Term] id: UPa:UCR00127 name: AMP + ATP = 2 ADP namespace: reaction xref: KEGG:R00127 "KEGG reaction" xref: METACYC:ADENYL-KIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12976 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00020 ! AMP relationship: has_input_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: part_of UPa:UER00649 {cardinality="1", direction="RL", order="1"} ! AMP from ADP: step 1/1 relationship: part_of UPa:UER00649 ! AMP from ADP: step 1/1 [Term] id: UPa:UCR00130 name: 3'-dephospho-CoA + ATP = ADP + CoA namespace: reaction xref: KEGG:R00130 "KEGG reaction" xref: METACYC:DEPHOSPHOCOAKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18248 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00882 {cardinality="1"} ! 3'-dephospho-CoA relationship: has_input_compound UPa:UPC00882 ! 3'-dephospho-CoA relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: part_of UPa:UER00356 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 5/5 relationship: part_of UPa:UER00356 ! CoA from (R)-pantothenate: step 5/5 [Term] id: UPa:UCR00131 name: H(2)O + urea = CO(2) + 2 NH(3) namespace: reaction xref: KEGG:R00131 "KEGG reaction" xref: METACYC:UREASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20560 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_input_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: part_of UPa:UER00370 ! CO(2) and NH(3) from urea (urease route): step 1/1 relationship: part_of UPa:UER00370 {cardinality="1", direction="LR", order="1"} ! CO(2) and NH(3) from urea (urease route): step 1/1 [Term] id: UPa:UCR00137 name: ATP + nicotinamide D-ribonucleotide = NAD(+) + diphosphate namespace: reaction xref: KEGG:R00137 "KEGG reaction" xref: METACYC:2.7.7.1-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21363 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00455 ! nicotinamide D-ribonucleotide relationship: has_input_compound UPa:UPC00455 {cardinality="1"} ! nicotinamide D-ribonucleotide relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: part_of UPa:UER00600 {cardinality="1", direction="LR", order="1"} ! NAD(+) from nicotinamide D-ribonucleotide: step 1/1 relationship: part_of UPa:UER00600 ! NAD(+) from nicotinamide D-ribonucleotide: step 1/1 [Term] id: UPa:UCR00150 name: ATP + CO(2) + NH(3) = ADP + carbamoyl phosphate namespace: reaction xref: KEGG:R00150 "KEGG reaction" xref: METACYC:CARBAMATE-KINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10155 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: part_of UPa:UER00366 ! CO(2) and NH(3) from carbamoyl phosphate: step 1/1 relationship: part_of UPa:UER00366 {cardinality="1", direction="RL", order="1"} ! CO(2) and NH(3) from carbamoyl phosphate: step 1/1 [Term] id: UPa:UCR00156 name: ATP + UDP = ADP + UTP namespace: reaction xref: KEGG:R00156 "KEGG reaction" xref: METACYC:UDPKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25101 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00015 ! UDP relationship: has_input_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00075 {cardinality="1"} ! UTP relationship: has_output_compound UPa:UPC00075 ! UTP relationship: part_of UPa:UER00276 ! CTP from UDP: step 1/2 relationship: part_of UPa:UER00276 {cardinality="1", direction="LR", order="1"} ! CTP from UDP: step 1/2 [Term] id: UPa:UCR00158 name: ATP + UMP = ADP + UDP namespace: reaction xref: KEGG:R00158 "KEGG reaction" xref: METACYC:RXN-12002 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24403 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: has_input_compound UPa:UPC00105 ! UMP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC00015 ! UDP relationship: part_of UPa:UER00274 {cardinality="1", direction="LR", order="1"} ! UDP from UMP (UMK/CMK route): step 1/1 relationship: part_of UPa:UER00274 ! UDP from UMP (UMK/CMK route): step 1/1 relationship: part_of UPa:UER00275 {cardinality="1", direction="LR", order="1"} ! UDP from UMP (UMPK route): step 1/1 relationship: part_of UPa:UER00275 ! UDP from UMP (UMPK route): step 1/1 [Term] id: UPa:UCR00161 name: ATP + FMN = FAD + diphosphate namespace: reaction xref: KEGG:R00161 "KEGG reaction" xref: METACYC:FADSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17240 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00061 {cardinality="1"} ! FMN relationship: has_input_compound UPa:UPC00061 ! FMN relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00016 {cardinality="1"} ! FAD relationship: has_output_compound UPa:UPC00016 ! FAD relationship: part_of UPa:UER00407 {cardinality="1", direction="LR", order="1"} ! FAD from FMN: step 1/1 relationship: part_of UPa:UER00407 ! FAD from FMN: step 1/1 [Term] id: UPa:UCR00173 name: H(2)O + pyridoxal 5'-phosphate = phosphate + pyridoxal namespace: reaction xref: KEGG:R00173 "KEGG reaction" xref: METACYC:3.1.3.74-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20536 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00018 ! pyridoxal 5'-phosphate relationship: has_input_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00250 ! pyridoxal relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: part_of UPa:UER00301 ! pyridoxal from pyridoxal 5'-phosphate: step 1/1 relationship: part_of UPa:UER00301 {cardinality="1", direction="LR", order="1"} ! pyridoxal from pyridoxal 5'-phosphate: step 1/1 [Term] id: UPa:UCR00174 name: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate namespace: reaction xref: KEGG:R00174 "KEGG reaction" xref: METACYC:PYRIDOXKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10227 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00250 ! pyridoxal relationship: has_input_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00018 ! pyridoxal 5'-phosphate relationship: part_of UPa:UER00298 {cardinality="1", direction="LR", order="1"} ! pyridoxal 5'-phosphate from pyridoxal: step 1/1 relationship: part_of UPa:UER00298 ! pyridoxal 5'-phosphate from pyridoxal: step 1/1 [Term] id: UPa:UCR00177 name: S-adenosyl-L-methionine + diphosphate + phosphate = ATP + H(2)O + L-methionine namespace: reaction xref: KEGG:R00177 "KEGG reaction" xref: METACYC:S-ADENMETSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21083 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00002 ! ATP relationship: has_output_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: part_of UPa:UER00080 ! S-adenosyl-L-methionine from L-methionine: step 1/1 relationship: part_of UPa:UER00080 {cardinality="1", direction="RL", order="1"} ! S-adenosyl-L-methionine from L-methionine: step 1/1 [Term] id: UPa:UCR00178 name: H(+) + S-adenosyl-L-methionine = CO(2) + S-adenosylmethioninamine namespace: reaction xref: KEGG:R00178 "KEGG reaction" xref: METACYC:SAMDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15984 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC01137 ! S-adenosylmethioninamine relationship: has_output_compound UPa:UPC01137 {cardinality="1"} ! S-adenosylmethioninamine relationship: part_of UPa:UER00451 {cardinality="1", direction="LR", order="1"} ! S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1 relationship: part_of UPa:UER00451 ! S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1 [Term] id: UPa:UCR00179 name: S-adenosyl-L-methionine = 1-aminocyclopropanecarboxylate + S-methyl-5'-thioadenosine namespace: reaction xref: KEGG:R00179 "KEGG reaction" xref: METACYC:4.4.1.14-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21747 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_output_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC01234 {cardinality="1"} ! 1-aminocyclopropanecarboxylate relationship: has_output_compound UPa:UPC01234 ! 1-aminocyclopropanecarboxylate relationship: part_of UPa:UER00562 {cardinality="1", direction="LR", order="1"} ! ethylene from S-adenosyl-L-methionine: step 1/2 relationship: part_of UPa:UER00562 ! ethylene from S-adenosyl-L-methionine: step 1/2 [Term] id: UPa:UCR00181 name: AMP + H(2)O = IMP + NH(3) namespace: reaction xref: KEGG:R00181 "KEGG reaction" xref: METACYC:AMP-DEAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14780 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_input_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00130 ! IMP relationship: has_output_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: part_of UPa:UER00663 ! IMP from AMP: step 1/1 relationship: part_of UPa:UER00663 {cardinality="1", direction="LR", order="1"} ! IMP from AMP: step 1/1 [Term] id: UPa:UCR00185 name: ATP + adenosine = ADP + AMP namespace: reaction xref: KEGG:R00185 "KEGG reaction" xref: METACYC:ADENOSINE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20827 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00212 {cardinality="1"} ! adenosine relationship: has_input_compound UPa:UPC00212 ! adenosine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: part_of UPa:UER00659 ! AMP from adenosine: step 1/1 relationship: part_of UPa:UER00659 {cardinality="1", direction="LR", order="1"} ! AMP from adenosine: step 1/1 [Term] id: UPa:UCR00189 name: ATP + NH(3) + deamido-NAD(+) = AMP + NAD(+) + diphosphate namespace: reaction xref: KEGG:R00189 "KEGG reaction" xref: METACYC:NAD-SYNTH-NH3-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21191 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00857 ! deamido-NAD(+) relationship: has_input_compound UPa:UPC00857 {cardinality="1"} ! deamido-NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: part_of UPa:UER00333 {cardinality="1", direction="LR", order="1"} ! NAD(+) from deamido-NAD(+) (ammonia route): step 1/1 relationship: part_of UPa:UER00333 ! NAD(+) from deamido-NAD(+) (ammonia route): step 1/1 [Term] id: UPa:UCR00190 name: AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine namespace: reaction xref: KEGG:R00190 "KEGG reaction" xref: METACYC:ADENPRIBOSYLTRAN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16612 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_input_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00147 {cardinality="1"} ! adenine relationship: has_output_compound UPa:UPC00147 ! adenine relationship: part_of UPa:UER00646 {cardinality="1", direction="RL", order="1"} ! AMP from adenine: step 1/1 relationship: part_of UPa:UER00646 ! AMP from adenine: step 1/1 [Term] id: UPa:UCR00191 name: 3',5'-cyclic AMP + H(2)O = AMP namespace: reaction xref: KEGG:R00191 "KEGG reaction" xref: METACYC:RXN0-5038 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25280 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00575 ! 3',5'-cyclic AMP relationship: has_input_compound UPa:UPC00575 {cardinality="1"} ! 3',5'-cyclic AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: part_of UPa:UER00747 ! AMP from 3',5'-cyclic AMP: step 1/1 relationship: part_of UPa:UER00747 {cardinality="1", direction="LR", order="1"} ! AMP from 3',5'-cyclic AMP: step 1/1 [Term] id: UPa:UCR00192 name: H(2)O + S-adenosyl-L-homocysteine = L-homocysteine + adenosine namespace: reaction xref: KEGG:R00192 "KEGG reaction" xref: METACYC:ADENOSYLHOMOCYSTEINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21711 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_input_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_output_compound UPa:UPC00155 ! L-homocysteine relationship: has_output_compound UPa:UPC00212 ! adenosine relationship: has_output_compound UPa:UPC00212 {cardinality="1"} ! adenosine relationship: part_of UPa:UER00076 ! L-homocysteine from S-adenosyl-L-homocysteine: step 1/1 relationship: part_of UPa:UER00076 {cardinality="1", direction="LR", order="1"} ! L-homocysteine from S-adenosyl-L-homocysteine: step 1/1 [Term] id: UPa:UCR00200 name: ATP + pyruvate = ADP + phosphoenolpyruvate namespace: reaction xref: KEGG:R00200 "KEGG reaction" xref: METACYC:PEPDEPHOS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18160 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_output_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: part_of UPa:UER00188 ! pyruvate from D-glyceraldehyde 3-phosphate: step 5/5 relationship: part_of UPa:UER00188 {cardinality="1", direction="RL", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 5/5 [Term] id: UPa:UCR00212 name: acetyl-CoA + formate = CoA + pyruvate namespace: reaction xref: KEGG:R00212 "KEGG reaction" xref: METACYC:PYRUVFORMLY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11847 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_input_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: part_of UPa:UER00891 {cardinality="1", direction="RL", order="1"} ! formate from pyruvate: step 1/1 relationship: part_of UPa:UER00891 ! formate from pyruvate: step 1/1 [Term] id: UPa:UCR00226 name: (S)-2-acetolactate + CO(2) = 2 pyruvate namespace: reaction xref: KEGG:R00226 "KEGG reaction" xref: METACYC:ACETOLACTSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25252 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC06010 {cardinality="1"} ! (S)-2-acetolactate relationship: has_input_compound UPa:UPC06010 ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: part_of UPa:UER00677 ! (R,R)-butane-2,3-diol from pyruvate: step 1/3 relationship: part_of UPa:UER00677 {cardinality="1", direction="RL", order="1"} ! (R,R)-butane-2,3-diol from pyruvate: step 1/3 [Term] id: UPa:UCR00228 name: CoA + NAD(+) + acetaldehyde = H(+) + NADH + acetyl-CoA namespace: reaction xref: KEGG:R00228 "KEGG reaction" xref: METACYC:ACETALD-DEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23291 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00084 ! acetaldehyde relationship: has_input_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:UER00798 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from acetaldehyde: step 1/1 relationship: part_of UPa:UER00798 ! acetyl-CoA from acetaldehyde: step 1/1 [Term] id: UPa:UCR00230 name: acetyl-CoA + phosphate = CoA + acetyl phosphate namespace: reaction xref: KEGG:R00230 "KEGG reaction" xref: METACYC:PHOSACETYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19524 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate relationship: has_output_compound UPa:UPC00227 ! acetyl phosphate relationship: part_of UPa:UER00459 {cardinality="1", direction="RL", order="1"} ! acetyl-CoA from acetate: step 2/2 relationship: part_of UPa:UER00459 ! acetyl-CoA from acetate: step 2/2 [Term] id: UPa:UCR00233 name: malonyl-CoA = CO(2) + acetyl-CoA namespace: reaction xref: KEGG:R00233 "KEGG reaction" xref: METACYC:MALONYL-COA-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18784 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00083 {cardinality="1"} ! malonyl-CoA relationship: has_input_compound UPa:UPC00083 ! malonyl-CoA relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: part_of UPa:UER00710 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from malonyl-CoA: step 1/1 relationship: part_of UPa:UER00710 ! acetyl-CoA from malonyl-CoA: step 1/1 [Term] id: UPa:UCR00238 name: 2 acetyl-CoA = CoA + acetoacetyl-CoA namespace: reaction xref: KEGG:R00238 "KEGG reaction" xref: METACYC:ACETYL-COA-ACETYLTRANSFER-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21039 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00332 ! acetoacetyl-CoA relationship: has_output_compound UPa:UPC00332 {cardinality="1"} ! acetoacetyl-CoA relationship: part_of UPa:UER00101 {cardinality="1", direction="LR", order="1"} ! (R)-mevalonate from acetyl-CoA: step 1/3 relationship: part_of UPa:UER00101 ! (R)-mevalonate from acetyl-CoA: step 1/3 [Term] id: UPa:UCR00239 name: ATP + L-glutamate = ADP + L-glutamyl 5-phosphate namespace: reaction xref: KEGG:R00239 "KEGG reaction" xref: METACYC:GLUTKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14880 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC03287 ! L-glutamyl 5-phosphate relationship: has_output_compound UPa:UPC03287 {cardinality="1"} ! L-glutamyl 5-phosphate relationship: part_of UPa:UER00359 {cardinality="1", direction="LR", order="1"} ! L-glutamate 5-semialdehyde from L-glutamate: step 1/2 relationship: part_of UPa:UER00359 ! L-glutamate 5-semialdehyde from L-glutamate: step 1/2 [Term] id: UPa:UCR00243 name: H(2)O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH(3) namespace: reaction xref: KEGG:R00243 "KEGG reaction" xref: METACYC:GLUTAMATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15136 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00591 ! crotonoyl-CoA from L-glutamate: step 1/5 relationship: part_of UPa:UER00591 {cardinality="1", direction="LR", order="1"} ! crotonoyl-CoA from L-glutamate: step 1/5 [Term] id: UPa:UCR00253 name: ATP + L-glutamate + NH(3) = ADP + L-glutamine + phosphate namespace: reaction xref: KEGG:R00253 "KEGG reaction" xref: METACYC:GLUTAMINESYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16172 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00064 ! L-glutamine relationship: part_of UPa:UER01025 {cardinality="1", direction="LR", order="1"} ! L-glutamine from L-glutamate: step 1/1 relationship: part_of UPa:UER01025 ! L-glutamine from L-glutamate: step 1/1 [Term] id: UPa:UCR00256 name: H(2)O + L-glutamine = L-glutamate + NH(3) namespace: reaction xref: KEGG:R00256 "KEGG reaction" xref: METACYC:GLUTAMIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15892 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: part_of UPa:UER00040 ! L-tryptophan from chorismate: step 1/5 relationship: part_of UPa:UER00040 {cardinality="1", direction="LR", order="2"} ! L-tryptophan from chorismate: step 1/5 relationship: part_of UPa:UER00149 ! 4-aminobenzoate from chorismate: step 1/2 relationship: part_of UPa:UER00149 {cardinality="1", direction="LR", order="2"} ! 4-aminobenzoate from chorismate: step 1/2 [Term] id: UPa:UCR00257 name: ATP + H(2)O + L-glutamine + deamido-NAD(+) = AMP + L-glutamate + NAD(+) + diphosphate namespace: reaction xref: KEGG:R00257 "KEGG reaction" xref: METACYC:NAD-SYNTH-GLN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24387 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00857 {cardinality="1"} ! deamido-NAD(+) relationship: has_input_compound UPa:UPC00857 ! deamido-NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: part_of UPa:UER00334 ! NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1 relationship: part_of UPa:UER00334 {cardinality="1", direction="LR", order="1"} ! NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1 [Term] id: UPa:UCR00258 name: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate namespace: reaction xref: KEGG:R00258 "KEGG reaction" xref: METACYC:ALANINE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19456 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: part_of UPa:UER00586 ! pyruvate from L-alanine: step 1/1 relationship: part_of UPa:UER00586 {cardinality="1", direction="LR", order="1"} ! pyruvate from L-alanine: step 1/1 [Term] id: UPa:UCR00259 name: L-glutamate + acetyl-CoA = CoA + N-acetyl-L-glutamate namespace: reaction xref: KEGG:R00259 "KEGG reaction" xref: METACYC:N-ACETYLTRANSFER-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24295 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00624 {cardinality="1"} ! N-acetyl-L-glutamate relationship: has_output_compound UPa:UPC00624 ! N-acetyl-L-glutamate relationship: part_of UPa:UER00106 ! N(2)-acetyl-L-ornithine from L-glutamate: step 1/4 relationship: part_of UPa:UER00106 {cardinality="1", direction="LR", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate: step 1/4 [Term] id: UPa:UCR00262 name: (2S,3S)-3-methyl-L-aspartate = L-glutamate namespace: reaction xref: KEGG:R00262 "KEGG reaction" xref: METACYC:METHYLASPARTATE-MUTASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12860 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03618 ! (2S,3S)-3-methyl-L-aspartate relationship: has_input_compound UPa:UPC03618 {cardinality="1"} ! (2S,3S)-3-methyl-L-aspartate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: part_of UPa:UER00617 {cardinality="1", direction="RL", order="1"} ! acetate and pyruvate from L-glutamate: step 1/4 relationship: part_of UPa:UER00617 ! acetate and pyruvate from L-glutamate: step 1/4 [Term] id: UPa:UCR00264 name: 2,5-dioxopentanoate + H(2)O + NADP(+) = 2-oxoglutarate + H(+) + NADPH namespace: reaction xref: KEGG:R00264 "KEGG reaction" xref: METACYC:25-DIOXOVALERATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11299 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00433 {cardinality="1"} ! 2,5-dioxopentanoate relationship: has_input_compound UPa:UPC00433 ! 2,5-dioxopentanoate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00573 ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate: step 2/2 relationship: part_of UPa:UER00573 {cardinality="1", direction="LR", order="1"} ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate: step 2/2 [Term] id: UPa:UCR00267 name: NADP(+) + isocitrate = 2-oxoglutarate + CO(2) + H(+) + NADPH namespace: reaction xref: KEGG:R00267 "KEGG reaction" xref: METACYC:ISOCITDEH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: METACYC:RXN-8642 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:19632 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00311 ! isocitrate relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00995 {cardinality="1", direction="LR", order="1"} ! 2-oxoglutarate from isocitrate (NADP(+) route): step 1/1 relationship: part_of UPa:UER00995 ! 2-oxoglutarate from isocitrate (NADP(+) route): step 1/1 [Term] id: UPa:UCR00271 name: 2-oxoglutarate + H(2)O + acetyl-CoA = (R)-homocitrate + CoA namespace: reaction xref: KEGG:R00271 "KEGG reaction" xref: METACYC:HOMOCITRATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12932 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC01251 {cardinality="1"} ! (R)-homocitrate relationship: has_output_compound UPa:UPC01251 ! (R)-homocitrate relationship: part_of UPa:UER00028 {cardinality="1", direction="LR", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 1/5 relationship: part_of UPa:UER00028 ! L-alpha-aminoadipate from 2-oxoglutarate: step 1/5 [Term] id: UPa:UCR00272 name: 2-oxoglutarate = CO(2) + succinate semialdehyde namespace: reaction xref: KEGG:R00272 "KEGG reaction" xref: METACYC:RXN-7774 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10527 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde relationship: has_output_compound UPa:UPC00232 ! succinate semialdehyde relationship: part_of UPa:UER01001 ! succinate from 2-oxoglutarate (transferase route): step 1/2 relationship: part_of UPa:UER01001 {cardinality="1", direction="LR", order="1"} ! succinate from 2-oxoglutarate (transferase route): step 1/2 [Term] id: UPa:UCR00277 name: H(2)O + O(2) + pyridoxamine 5'-phosphate = H(2)O(2) + NH(3) + pyridoxal 5'-phosphate namespace: reaction xref: KEGG:R00277 "KEGG reaction" xref: METACYC:PMPOXI-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15820 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00647 {cardinality="1"} ! pyridoxamine 5'-phosphate relationship: has_input_compound UPa:UPC00647 ! pyridoxamine 5'-phosphate relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00018 ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: part_of UPa:UER00304 ! pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1 relationship: part_of UPa:UER00304 {cardinality="1", direction="LR", order="1"} ! pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1 [Term] id: UPa:UCR00278 name: O(2) + pyridoxine 5'-phosphate = H(2)O(2) + pyridoxal 5'-phosphate namespace: reaction xref: KEGG:R00278 "KEGG reaction" xref: METACYC:PNPOXI-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15152 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate relationship: has_input_compound UPa:UPC00627 ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00018 ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: part_of UPa:UER00305 ! pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1 relationship: part_of UPa:UER00305 {cardinality="1", direction="LR", order="1"} ! pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1 [Term] id: UPa:UCR00286 name: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 2 H(+) + 2 NADH + UDP-alpha-D-glucuronate namespace: reaction xref: KEGG:R00286 "KEGG reaction" xref: METACYC:UGD-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23599 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00029 {cardinality="1"} ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC00029 ! UDP-alpha-D-glucose relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate relationship: part_of UPa:UER00491 ! UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1 relationship: part_of UPa:UER00491 {cardinality="1", direction="LR", order="1"} ! UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1 [Term] id: UPa:UCR00294 name: 2 H(+) + 2 ferrocytochrome c + 2 nitric oxide = H(2)O + 2 ferricytochrome c + nitrous oxide namespace: reaction xref: KEGG:R00294 "KEGG reaction" xref: METACYC:NITRIC-OXIDE-REDUCTASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10991 "Rhea reaction" xref: RHEA:30214 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c relationship: has_input_compound UPa:UPC00126 ! ferrocytochrome c relationship: has_input_compound UPa:UPC00533 ! nitric oxide relationship: has_input_compound UPa:UPC00533 {cardinality="1"} ! nitric oxide relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c relationship: has_output_compound UPa:UPC00125 ! ferricytochrome c relationship: has_output_compound UPa:UPC00887 ! nitrous oxide relationship: has_output_compound UPa:UPC00887 {cardinality="1"} ! nitrous oxide relationship: part_of UPa:UER00708 {cardinality="1", direction="LR", order="1"} ! dinitrogen from nitrate: step 3/4 relationship: part_of UPa:UER00708 ! dinitrogen from nitrate: step 3/4 [Term] id: UPa:UCR00299 name: ATP + D-glucose = ADP + D-glucose 6-phosphate namespace: reaction xref: KEGG:R00299 "KEGG reaction" xref: METACYC:GLUCOKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17828 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00031 ! D-glucose relationship: has_input_compound UPa:UPC00031 {cardinality="1"} ! D-glucose relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: part_of UPa:UER00180 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4 relationship: part_of UPa:UER00180 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4 [Term] id: UPa:UCR00310 name: Fe2+ + protoporphyrin-IX = 2 H(+) + protoheme namespace: reaction xref: KEGG:R00310 "KEGG reaction" xref: METACYC:PROTOHEMEFERROCHELAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22587 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02191 ! protoporphyrin-IX relationship: has_input_compound UPa:UPC02191 {cardinality="1"} ! protoporphyrin-IX relationship: has_input_compound UPa:UPC14818 {cardinality="1"} ! Fe2+ relationship: has_input_compound UPa:UPC14818 ! Fe2+ relationship: has_output_compound UPa:UPC00032 {cardinality="1"} ! protoheme relationship: has_output_compound UPa:UPC00032 ! protoheme relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:UER00325 {cardinality="1", direction="LR", order="1"} ! protoheme from protoporphyrin-IX: step 1/1 relationship: part_of UPa:UER00325 ! protoheme from protoporphyrin-IX: step 1/1 [Term] id: UPa:UCR00315 name: ATP + acetate = ADP + acetyl phosphate namespace: reaction xref: KEGG:R00315 "KEGG reaction" xref: METACYC:ACETATEKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11355 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_input_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate relationship: has_output_compound UPa:UPC00227 ! acetyl phosphate relationship: part_of UPa:UER00458 ! acetyl-CoA from acetate: step 1/2 relationship: part_of UPa:UER00458 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from acetate: step 1/2 [Term] id: UPa:UCR00325 name: L-citramalate = acetate + pyruvate namespace: reaction xref: KEGG:R00325 "KEGG reaction" xref: METACYC:CITRAMALATE-LYASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15548 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02614 {cardinality="1"} ! L-citramalate relationship: has_input_compound UPa:UPC02614 ! L-citramalate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: part_of UPa:UER00620 {cardinality="1", direction="LR", order="1"} ! acetate and pyruvate from L-glutamate: step 4/4 relationship: part_of UPa:UER00620 ! acetate and pyruvate from L-glutamate: step 4/4 [Term] id: UPa:UCR00336 name: H(2)O + ppGpp = GDP + diphosphate namespace: reaction xref: KEGG:R00336 "KEGG reaction" xref: METACYC:PPGPPSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14256 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC01228 {cardinality="1"} ! ppGpp relationship: has_input_compound UPa:UPC01228 ! ppGpp relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_output_compound UPa:UPC00035 ! GDP relationship: part_of UPa:UER00886 ! ppGpp from GDP: step 1/1 relationship: part_of UPa:UER00886 {cardinality="1", direction="RL", order="1"} ! ppGpp from GDP: step 1/1 [Term] id: UPa:UCR00342 name: (S)-malate + NAD(+) = H(+) + NADH + oxaloacetate namespace: reaction xref: KEGG:R00342 "KEGG reaction" xref: METACYC:MALATE-DEH-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21435 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00149 ! (S)-malate relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00036 ! oxaloacetate relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00721 ! oxaloacetate from (S)-malate: step 1/1 relationship: part_of UPa:UER00721 {cardinality="1", direction="LR", order="1"} ! oxaloacetate from (S)-malate: step 1/1 [Term] id: UPa:UCR00351 name: CoA + citrate = H(2)O + acetyl-CoA + oxaloacetate namespace: reaction xref: KEGG:R00351 "KEGG reaction" xref: METACYC:CITSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16848 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00158 {cardinality="1"} ! citrate relationship: has_input_compound UPa:UPC00158 ! citrate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: has_output_compound UPa:UPC00036 ! oxaloacetate relationship: part_of UPa:UER00717 ! isocitrate from oxaloacetate: step 1/2 relationship: part_of UPa:UER00717 {cardinality="1", direction="RL", order="1"} ! isocitrate from oxaloacetate: step 1/2 [Term] id: UPa:UCR00355 name: 2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate namespace: reaction xref: KEGG:R00355 "KEGG reaction" xref: METACYC:ASPAMINOTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21827 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: has_output_compound UPa:UPC00036 ! oxaloacetate relationship: part_of UPa:UER01024 ! L-aspartate from oxaloacetate: step 1/1 relationship: part_of UPa:UER01024 {cardinality="1", direction="RL", order="1"} ! L-aspartate from oxaloacetate: step 1/1 [Term] id: UPa:UCR00361 name: (S)-malate + Quinone = Hydroquinone + oxaloacetate namespace: reaction xref: KEGG:R00361 "KEGG reaction" xref: METACYC:MALATE-DEHYDROGENASE-ACCEPTOR-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22559 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00149 ! (S)-malate relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate relationship: has_input_compound UPa:UPC15602 ! Quinone relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone relationship: has_output_compound UPa:UPC00036 ! oxaloacetate relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: has_output_compound UPa:UPC15603 ! Hydroquinone relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone relationship: part_of UPa:UER01008 ! oxaloacetate from (S)-malate (quinone route): step 1/1 relationship: part_of UPa:UER01008 {cardinality="1", direction="LR", order="1"} ! oxaloacetate from (S)-malate (quinone route): step 1/1 [Term] id: UPa:UCR00367 name: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine namespace: reaction xref: KEGG:R00367 "KEGG reaction" xref: METACYC:GLYCINE-N-METHYLTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19940 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00213 ! sarcosine relationship: has_output_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: part_of UPa:UER00381 ! betaine from glycine: step 1/3 relationship: part_of UPa:UER00381 {cardinality="1", direction="LR", order="1"} ! betaine from glycine: step 1/3 [Term] id: UPa:UCR00369 name: L-alanine + glyoxylate = glycine + pyruvate namespace: reaction xref: KEGG:R00369 "KEGG reaction" xref: METACYC:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24251 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_input_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: has_input_compound UPa:UPC00048 ! glyoxylate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: part_of UPa:UER00428 {cardinality="1", direction="LR", order="1"} ! glycine from glyoxylate: step 1/1 relationship: part_of UPa:UER00428 ! glycine from glyoxylate: step 1/1 [Term] id: UPa:UCR00371 name: acetyl-CoA + glycine = CoA + L-2-amino-3-oxobutanoic acid namespace: reaction xref: KEGG:R00371 "KEGG reaction" xref: METACYC:AKBLIG-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:20739 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC03508 ! L-2-amino-3-oxobutanoic acid relationship: has_output_compound UPa:UPC03508 {cardinality="1"} ! L-2-amino-3-oxobutanoic acid relationship: part_of UPa:UER00506 ! glycine from L-threonine: step 2/2 relationship: part_of UPa:UER00506 {cardinality="1", direction="RL", order="1"} ! glycine from L-threonine: step 2/2 [Term] id: UPa:UCR00372 name: 2-oxoglutarate + glycine = L-glutamate + glyoxylate namespace: reaction xref: KEGG:R00372 "KEGG reaction" xref: METACYC:GLYCINE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14092 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: has_output_compound UPa:UPC00048 ! glyoxylate relationship: part_of UPa:UER00913 ! glycine from 2-phosphoglycolate: step 3/3 relationship: part_of UPa:UER00913 {cardinality="1", direction="RL", order="1"} ! glycine from 2-phosphoglycolate: step 3/3 [Term] id: UPa:UCR00396 name: H(2)O + L-alanine + NAD(+) = H(+) + NADH + NH(3) + pyruvate namespace: reaction xref: KEGG:R00396 "KEGG reaction" xref: METACYC:ALANINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18408 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:UER00585 ! NH(3) and pyruvate from L-alanine: step 1/1 relationship: part_of UPa:UER00585 {cardinality="1", direction="LR", order="1"} ! NH(3) and pyruvate from L-alanine: step 1/1 [Term] id: UPa:UCR00401 name: L-alanine = D-alanine namespace: reaction xref: KEGG:R00401 "KEGG reaction" xref: METACYC:ALARACECAT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20252 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00133 ! D-alanine relationship: has_output_compound UPa:UPC00133 {cardinality="1"} ! D-alanine relationship: part_of UPa:UER00497 ! D-alanine from L-alanine: step 1/1 relationship: part_of UPa:UER00497 {cardinality="1", direction="LR", order="1"} ! D-alanine from L-alanine: step 1/1 [Term] id: UPa:UCR00405 name: ATP + CoA + succinate = ADP + phosphate + succinyl-CoA namespace: reaction xref: KEGG:R00405 "KEGG reaction" xref: METACYC:SUCCCOASYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17664 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00042 ! succinate relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_output_compound UPa:UPC00091 ! succinyl-CoA relationship: part_of UPa:UER00999 {cardinality="1", direction="RL", order="1"} ! succinate from succinyl-CoA (ligase route): step 1/1 relationship: part_of UPa:UER00999 ! succinate from succinyl-CoA (ligase route): step 1/1 [Term] id: UPa:UCR00410 name: acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate namespace: reaction xref: KEGG:R00410 "KEGG reaction" xref: METACYC:RXNI-2 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25483 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00164 ! acetoacetate relationship: has_input_compound UPa:UPC00164 {cardinality="1"} ! acetoacetate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00332 ! acetoacetyl-CoA relationship: has_output_compound UPa:UPC00332 {cardinality="1"} ! acetoacetyl-CoA relationship: part_of UPa:UER00894 ! acetoacetyl-CoA from succinyl-CoA: step 1/1 relationship: part_of UPa:UER00894 {cardinality="1", direction="LR", order="1"} ! acetoacetyl-CoA from succinyl-CoA: step 1/1 relationship: part_of UPa:UER01000 {cardinality="1", direction="LR", order="1"} ! succinate from succinyl-CoA (transferase route): step 1/1 relationship: part_of UPa:UER01000 ! succinate from succinyl-CoA (transferase route): step 1/1 [Term] id: UPa:UCR00411 name: H(2)O + N(2)-succinyl-L-glutamic acid = L-glutamate + succinate namespace: reaction xref: KEGG:R00411 "KEGG reaction" xref: METACYC:SUCCGLUDESUCC-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15172 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC05931 ! N(2)-succinyl-L-glutamic acid relationship: has_input_compound UPa:UPC05931 {cardinality="1"} ! N(2)-succinyl-L-glutamic acid relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: part_of UPa:UER00283 ! L-glutamate and succinate from L-arginine: step 5/5 relationship: part_of UPa:UER00283 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 5/5 [Term] id: UPa:UCR00412 name: acceptor + succinate = fumarate + reduced acceptor namespace: reaction xref: KEGG:R00412 "KEGG reaction" xref: RHEA:16360 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_input_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: part_of UPa:UER01005 ! fumarate from succinate (bacterial route): step 1/1 relationship: part_of UPa:UER01005 {cardinality="1", direction="LR", order="1"} ! fumarate from succinate (bacterial route): step 1/1 [Term] id: UPa:UCR00416 name: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = UDP-N-acetyl-alpha-D-glucosamine + diphosphate namespace: reaction xref: KEGG:R00416 "KEGG reaction" xref: METACYC:NAG1P-URIDYLTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13512 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00075 ! UTP relationship: has_input_compound UPa:UPC00075 {cardinality="1"} ! UTP relationship: has_input_compound UPa:UPC04501 ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_input_compound UPa:UPC04501 {cardinality="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00043 ! UDP-N-acetyl-alpha-D-glucosamine relationship: has_output_compound UPa:UPC00043 {cardinality="1"} ! UDP-N-acetyl-alpha-D-glucosamine relationship: part_of UPa:UER00533 ! UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1 relationship: part_of UPa:UER00533 {cardinality="1", direction="LR", order="1"} ! UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1 [Term] id: UPa:UCR00425 name: GTP + 3 H(2)O = 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine + diphosphate + formate namespace: reaction xref: KEGG:R00425 "KEGG reaction" xref: METACYC:GTP-CYCLOHYDRO-II-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23707 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC01304 {cardinality="1"} ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine relationship: has_output_compound UPa:UPC01304 ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine relationship: part_of UPa:UER00400 {cardinality="1", direction="LR", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4 relationship: part_of UPa:UER00400 ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4 [Term] id: UPa:UCR00428 name: GTP + H(2)O = formamidopyrimidine nucleoside triphosphate namespace: reaction xref: KEGG:R00428 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_output_compound UPa:UPC05922 ! formamidopyrimidine nucleoside triphosphate relationship: has_output_compound UPa:UPC05922 {cardinality="1"} ! formamidopyrimidine nucleoside triphosphate relationship: part_of UPa:UER00151 ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1 relationship: part_of UPa:UER00151 {cardinality="1", direction="LR", order="1"} ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1 [Term] id: UPa:UCR00429 name: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate namespace: reaction xref: KEGG:R00429 "KEGG reaction" xref: METACYC:GTPPYPHOSKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22091 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC04494 {cardinality="1"} ! guanosine 3'-diphosphate 5'-triphosphate relationship: has_output_compound UPa:UPC04494 ! guanosine 3'-diphosphate 5'-triphosphate relationship: part_of UPa:UER00884 {cardinality="1", direction="LR", order="1"} ! ppGpp from GTP: step 1/2 relationship: part_of UPa:UER00884 ! ppGpp from GTP: step 1/2 [Term] id: UPa:UCR00451 name: DL-2,6-diaminopimelate = CO(2) + L-lysine namespace: reaction xref: KEGG:R00451 "KEGG reaction" xref: METACYC:DIAMINOPIMDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15104 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00680 ! DL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC00680 {cardinality="1"} ! DL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_output_compound UPa:UPC00047 ! L-lysine relationship: part_of UPa:UER00027 ! L-lysine from DL-2,6-diaminopimelate: step 1/1 relationship: part_of UPa:UER00027 {cardinality="1", direction="LR", order="1"} ! L-lysine from DL-2,6-diaminopimelate: step 1/1 [Term] id: UPa:UCR00469 name: (S)-ureidoglycolate + H(2)O = CO(2) + 2 NH(3) + glyoxylate namespace: reaction xref: KEGG:R00469 "KEGG reaction" xref: METACYC:UREIDOGLYCOLATE-HYDROLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19812 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: has_input_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00048 ! glyoxylate relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: part_of UPa:UER00656 {cardinality="1", direction="LR", order="1"} ! glyoxylate from (S)-ureidoglycolate: step 1/1 relationship: part_of UPa:UER00656 ! glyoxylate from (S)-ureidoglycolate: step 1/1 [Term] id: UPa:UCR00472 name: (S)-malate + CoA = H(2)O + acetyl-CoA + glyoxylate namespace: reaction xref: KEGG:R00472 "KEGG reaction" xref: METACYC:MALSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18184 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate relationship: has_input_compound UPa:UPC00149 ! (S)-malate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: has_output_compound UPa:UPC00048 ! glyoxylate relationship: part_of UPa:UER00720 ! (S)-malate from isocitrate: step 2/2 relationship: part_of UPa:UER00720 {cardinality="1", direction="RL", order="1"} ! (S)-malate from isocitrate: step 2/2 [Term] id: UPa:UCR00475 name: O(2) + glycolate = H(2)O(2) + glyoxylate namespace: reaction xref: KEGG:R00475 "KEGG reaction" xref: METACYC:RXN-969 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25314 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00160 {cardinality="1"} ! glycolate relationship: has_input_compound UPa:UPC00160 ! glycolate relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: has_output_compound UPa:UPC00048 ! glyoxylate relationship: part_of UPa:UER00912 ! glycine from 2-phosphoglycolate: step 2/3 relationship: part_of UPa:UER00912 {cardinality="1", direction="LR", order="1"} ! glycine from 2-phosphoglycolate: step 2/3 [Term] id: UPa:UCR00476 name: acceptor + glycolate = glyoxylate + reduced acceptor namespace: reaction xref: KEGG:R00476 "KEGG reaction" xref: METACYC:GLYCOLATEDEHYDRO-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21267 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00160 {cardinality="1"} ! glycolate relationship: has_input_compound UPa:UPC00160 ! glycolate relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: has_output_compound UPa:UPC00048 ! glyoxylate relationship: part_of UPa:UER00830 ! 3-phospho-D-glycerate from glycolate: step 1/4 relationship: part_of UPa:UER00830 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycolate: step 1/4 [Term] id: UPa:UCR00479 name: isocitrate = glyoxylate + succinate namespace: reaction xref: KEGG:R00479 "KEGG reaction" xref: METACYC:ISOCIT-CLEAV-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13248 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00311 ! isocitrate relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: has_output_compound UPa:UPC00048 ! glyoxylate relationship: part_of UPa:UER00719 {cardinality="1", direction="LR", order="1"} ! (S)-malate from isocitrate: step 1/2 relationship: part_of UPa:UER00719 ! (S)-malate from isocitrate: step 1/2 [Term] id: UPa:UCR00480 name: ATP + L-aspartate = 4-phospho-L-aspartate + ADP namespace: reaction xref: KEGG:R00480 "KEGG reaction" xref: METACYC:ASPARTATEKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23779 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC03082 ! 4-phospho-L-aspartate relationship: has_output_compound UPa:UPC03082 {cardinality="1"} ! 4-phospho-L-aspartate relationship: part_of UPa:UER00015 {cardinality="1", direction="LR", order="1"} ! (S)-tetrahydrodipicolinate from L-aspartate: step 1/4 relationship: part_of UPa:UER00015 ! (S)-tetrahydrodipicolinate from L-aspartate: step 1/4 relationship: part_of UPa:UER00461 {cardinality="1", direction="LR", order="1"} ! L-threonine from L-aspartate: step 1/5 relationship: part_of UPa:UER00461 ! L-threonine from L-aspartate: step 1/5 relationship: part_of UPa:UER00462 {cardinality="1", direction="LR", order="1"} ! L-homoserine from L-aspartate: step 1/3 relationship: part_of UPa:UER00462 ! L-homoserine from L-aspartate: step 1/3 [Term] id: UPa:UCR00481 name: L-aspartate + O(2) = H(2)O(2) + iminoaspartate namespace: reaction xref: KEGG:R00481 "KEGG reaction" xref: RHEA:25879 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC05840 ! iminoaspartate relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate relationship: part_of UPa:UER00326 {cardinality="1", direction="LR", order="1"} ! iminoaspartate from L-aspartate (oxidase route): step 1/1 relationship: part_of UPa:UER00326 ! iminoaspartate from L-aspartate (oxidase route): step 1/1 [Term] id: UPa:UCR00483 name: ATP + L-aspartate + NH(3) = AMP + L-asparagine + diphosphate namespace: reaction xref: KEGG:R00483 "KEGG reaction" xref: METACYC:ASNSYNA-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11375 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00152 {cardinality="1"} ! L-asparagine relationship: has_output_compound UPa:UPC00152 ! L-asparagine relationship: part_of UPa:UER00194 {cardinality="1", direction="LR", order="1"} ! L-asparagine from L-aspartate (ammonia route): step 1/1 relationship: part_of UPa:UER00194 ! L-asparagine from L-aspartate (ammonia route): step 1/1 [Term] id: UPa:UCR00489 name: L-aspartate = CO(2) + beta-alanine namespace: reaction xref: KEGG:R00489 "KEGG reaction" xref: METACYC:ASPDECARBOX-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19500 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00099 ! beta-alanine relationship: has_output_compound UPa:UPC00099 {cardinality="1"} ! beta-alanine relationship: part_of UPa:UER00002 {cardinality="1", direction="LR", order="1"} ! beta-alanine from L-aspartate: step 1/1 relationship: part_of UPa:UER00002 ! beta-alanine from L-aspartate: step 1/1 [Term] id: UPa:UCR00497 name: ATP + L-gamma-glutamyl-L-cysteine + glycine = ADP + glutathione + phosphate namespace: reaction xref: KEGG:R00497 "KEGG reaction" xref: METACYC:GLUTATHIONE-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13560 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00669 ! L-gamma-glutamyl-L-cysteine relationship: has_input_compound UPa:UPC00669 {cardinality="1"} ! L-gamma-glutamyl-L-cysteine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione relationship: has_output_compound UPa:UPC00051 ! glutathione relationship: part_of UPa:UER00210 ! glutathione from L-cysteine and L-glutamate: step 2/2 relationship: part_of UPa:UER00210 {cardinality="1", direction="LR", order="1"} ! glutathione from L-cysteine and L-glutamate: step 2/2 [Term] id: UPa:UCR00509 name: 5'-adenylyl sulfate + ATP = 3'-phospho-5'-adenylyl sulfate + ADP namespace: reaction xref: KEGG:R00509 "KEGG reaction" xref: METACYC:ADENYLYLSULFKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24155 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00224 ! 5'-adenylyl sulfate relationship: has_input_compound UPa:UPC00224 {cardinality="1"} ! 5'-adenylyl sulfate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00053 {cardinality="1"} ! 3'-phospho-5'-adenylyl sulfate relationship: has_output_compound UPa:UPC00053 ! 3'-phospho-5'-adenylyl sulfate relationship: part_of UPa:UER00205 {cardinality="1", direction="LR", order="1"} ! sulfite from sulfate: step 2/3 relationship: part_of UPa:UER00205 ! sulfite from sulfate: step 2/3 [Term] id: UPa:UCR00512 name: ATP + CMP = ADP + CDP namespace: reaction xref: KEGG:R00512 "KEGG reaction" xref: METACYC:RXN-11832 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11603 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00055 ! CMP relationship: has_input_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00112 ! CDP relationship: has_output_compound UPa:UPC00112 {cardinality="1"} ! CDP relationship: part_of UPa:UER00641 ! CTP from cytidine: step 2/3 relationship: part_of UPa:UER00641 {cardinality="1", direction="LR", order="1"} ! CTP from cytidine: step 2/3 [Term] id: UPa:UCR00513 name: ATP + cytidine = ADP + CMP namespace: reaction xref: KEGG:R00513 "KEGG reaction" xref: METACYC:CYTIKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24677 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00475 {cardinality="1"} ! cytidine relationship: has_input_compound UPa:UPC00475 ! cytidine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: part_of UPa:UER00640 {cardinality="1", direction="LR", order="1"} ! CTP from cytidine: step 1/3 relationship: part_of UPa:UER00640 ! CTP from cytidine: step 1/3 [Term] id: UPa:UCR00525 name: H(2)O + N-formyl-L-glutamate = L-glutamate + formate namespace: reaction xref: KEGG:R00525 "KEGG reaction" xref: METACYC:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12479 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01045 {cardinality="1"} ! N-formyl-L-glutamate relationship: has_input_compound UPa:UPC01045 ! N-formyl-L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: part_of UPa:UER00554 {cardinality="1", direction="LR", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route): step 2/2 relationship: part_of UPa:UER00554 ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route): step 2/2 [Term] id: UPa:UCR00527 name: H(2)O + S-formylglutathione = formate + glutathione namespace: reaction xref: KEGG:R00527 "KEGG reaction" xref: METACYC:S-FORMYLGLUTATHIONE-HYDROLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14964 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01031 {cardinality="1"} ! S-formylglutathione relationship: has_input_compound UPa:UPC01031 ! S-formylglutathione relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione relationship: has_output_compound UPa:UPC00051 ! glutathione relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: part_of UPa:UER00623 ! formate from formaldehyde (glutathione route): step 3/3 relationship: part_of UPa:UER00623 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (glutathione route): step 3/3 [Term] id: UPa:UCR00529 name: ATP + sulfate = 5'-adenylyl sulfate + diphosphate namespace: reaction xref: KEGG:R00529 "KEGG reaction" xref: METACYC:SULFATE-ADENYLYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18136 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00059 {cardinality="1"} ! sulfate relationship: has_input_compound UPa:UPC00059 ! sulfate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00224 {cardinality="1"} ! 5'-adenylyl sulfate relationship: has_output_compound UPa:UPC00224 ! 5'-adenylyl sulfate relationship: part_of UPa:UER00204 {cardinality="1", direction="LR", order="1"} ! sulfite from sulfate: step 1/3 relationship: part_of UPa:UER00204 ! sulfite from sulfate: step 1/3 [Term] id: UPa:UCR00549 name: ATP + riboflavin = ADP + FMN namespace: reaction xref: KEGG:R00549 "KEGG reaction" xref: METACYC:RIBOFLAVINKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14360 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00255 ! riboflavin relationship: has_input_compound UPa:UPC00255 {cardinality="1"} ! riboflavin relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00061 {cardinality="1"} ! FMN relationship: has_output_compound UPa:UPC00061 ! FMN relationship: part_of UPa:UER00406 ! FMN from riboflavin (ATP route): step 1/1 relationship: part_of UPa:UER00406 {cardinality="1", direction="LR", order="1"} ! FMN from riboflavin (ATP route): step 1/1 [Term] id: UPa:UCR00551 name: H(2)O + L-arginine = L-ornithine + urea namespace: reaction xref: KEGG:R00551 "KEGG reaction" xref: METACYC:ARGINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20572 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_output_compound UPa:UPC00086 ! urea relationship: part_of UPa:UER00270 {cardinality="1", direction="LR", order="1"} ! L-ornithine and urea from L-arginine: step 1/1 relationship: part_of UPa:UER00270 ! L-ornithine and urea from L-arginine: step 1/1 [Term] id: UPa:UCR00552 name: H(2)O + L-arginine = L-citrulline + NH(3) namespace: reaction xref: KEGG:R00552 "KEGG reaction" xref: METACYC:ARGININE-DEIMINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19600 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00327 ! L-citrulline relationship: has_output_compound UPa:UPC00327 {cardinality="1"} ! L-citrulline relationship: part_of UPa:UER00364 ! carbamoyl phosphate from L-arginine: step 1/2 relationship: part_of UPa:UER00364 {cardinality="1", direction="LR", order="1"} ! carbamoyl phosphate from L-arginine: step 1/2 [Term] id: UPa:UCR00565 name: L-arginine + glycine = L-ornithine + guanidinoacetate namespace: reaction xref: KEGG:R00565 "KEGG reaction" xref: METACYC:GLYCINE-AMIDINOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13204 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00581 {cardinality="1"} ! guanidinoacetate relationship: has_output_compound UPa:UPC00581 ! guanidinoacetate relationship: part_of UPa:UER00579 {cardinality="1", direction="LR", order="1"} ! creatine from L-arginine and glycine: step 1/2 relationship: part_of UPa:UER00579 ! creatine from L-arginine and glycine: step 1/2 [Term] id: UPa:UCR00566 name: L-arginine = CO(2) + agmatine namespace: reaction xref: KEGG:R00566 "KEGG reaction" xref: METACYC:ARGDECARBOX-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17644 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00179 {cardinality="1"} ! agmatine relationship: has_output_compound UPa:UPC00179 ! agmatine relationship: part_of UPa:UER00284 ! agmatine from L-arginine: step 1/1 relationship: part_of UPa:UER00284 {cardinality="1", direction="LR", order="1"} ! agmatine from L-arginine: step 1/1 [Term] id: UPa:UCR00570 name: ATP + CDP = ADP + CTP namespace: reaction xref: KEGG:R00570 "KEGG reaction" xref: METACYC:CDPKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25240 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00112 ! CDP relationship: has_input_compound UPa:UPC00112 {cardinality="1"} ! CDP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_output_compound UPa:UPC00063 ! CTP relationship: part_of UPa:UER00642 ! CTP from cytidine: step 3/3 relationship: part_of UPa:UER00642 {cardinality="1", direction="LR", order="1"} ! CTP from cytidine: step 3/3 [Term] id: UPa:UCR00571 name: ATP + NH(3) + UTP = ADP + CTP + phosphate namespace: reaction xref: KEGG:R00571 "KEGG reaction" xref: RHEA:16600 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00075 {cardinality="1"} ! UTP relationship: has_input_compound UPa:UPC00075 ! UTP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_output_compound UPa:UPC00063 ! CTP relationship: part_of UPa:UER00277 ! CTP from UDP: step 2/2 relationship: part_of UPa:UER00277 {cardinality="1", direction="LR", order="1"} ! CTP from UDP: step 2/2 [Term] id: UPa:UCR00575 name: 2 ATP + H(2)O + L-glutamine + bicarbonate = 2 ADP + L-glutamate + carbamoyl phosphate + phosphate namespace: reaction xref: KEGG:R00575 "KEGG reaction" xref: METACYC:CARBPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18636 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: part_of UPa:UER00115 ! (S)-dihydroorotate from bicarbonate: step 1/3 relationship: part_of UPa:UER00115 {cardinality="1", direction="LR", order="1"} ! (S)-dihydroorotate from bicarbonate: step 1/3 relationship: part_of UPa:UER00171 {cardinality="1", direction="LR", order="1"} ! carbamoyl phosphate from bicarbonate: step 1/1 relationship: part_of UPa:UER00171 ! carbamoyl phosphate from bicarbonate: step 1/1 [Term] id: UPa:UCR00578 name: ATP + H(2)O + L-aspartate + L-glutamine = AMP + L-asparagine + L-glutamate + diphosphate namespace: reaction xref: KEGG:R00578 "KEGG reaction" xref: METACYC:ASNSYNB-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12231 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00152 ! L-asparagine relationship: has_output_compound UPa:UPC00152 {cardinality="1"} ! L-asparagine relationship: part_of UPa:UER00195 ! L-asparagine from L-aspartate (L-Gln route): step 1/1 relationship: part_of UPa:UER00195 {cardinality="1", direction="LR", order="1"} ! L-asparagine from L-aspartate (L-Gln route): step 1/1 [Term] id: UPa:UCR00582 name: H(2)O + O-phospho-L-serine = L-serine + phosphate namespace: reaction xref: KEGG:R00582 "KEGG reaction" xref: METACYC:RXN0-5114 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21211 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01005 {cardinality="1"} ! O-phospho-L-serine relationship: has_input_compound UPa:UPC01005 ! O-phospho-L-serine relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00065 ! L-serine relationship: has_output_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: part_of UPa:UER00198 ! L-serine from 3-phospho-D-glycerate: step 3/3 relationship: part_of UPa:UER00198 {cardinality="1", direction="LR", order="1"} ! L-serine from 3-phospho-D-glycerate: step 3/3 [Term] id: UPa:UCR00585 name: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine namespace: reaction xref: KEGG:R00585 "KEGG reaction" xref: METACYC:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22855 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_output_compound UPa:UPC00041 ! L-alanine relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00168 {cardinality="1"} ! 3-hydroxypyruvate relationship: has_output_compound UPa:UPC00168 ! 3-hydroxypyruvate relationship: part_of UPa:UER00915 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycine: step 2/4 relationship: part_of UPa:UER00915 ! 3-phospho-D-glycerate from glycine: step 2/4 [Term] id: UPa:UCR00586 name: L-serine + acetyl-CoA = CoA + O-acetyl-L-serine namespace: reaction xref: KEGG:R00586 "KEGG reaction" xref: METACYC:SERINE-O-ACETTRAN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24563 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00979 ! O-acetyl-L-serine relationship: has_output_compound UPa:UPC00979 {cardinality="1"} ! O-acetyl-L-serine relationship: part_of UPa:UER00199 {cardinality="1", direction="LR", order="1"} ! L-cysteine from L-serine: step 1/2 relationship: part_of UPa:UER00199 ! L-cysteine from L-serine: step 1/2 [Term] id: UPa:UCR00605 name: NAD(+) + methanol = H(+) + NADH + formaldehyde namespace: reaction xref: KEGG:R00605 "KEGG reaction" xref: METACYC:METHANOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19404 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00132 ! methanol relationship: has_input_compound UPa:UPC00132 {cardinality="1"} ! methanol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_output_compound UPa:UPC00067 ! formaldehyde relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:UER00893 {cardinality="1", direction="LR", order="1"} ! formaldehyde from methanol: step 1/1 relationship: part_of UPa:UER00893 ! formaldehyde from methanol: step 1/1 [Term] id: UPa:UCR00606 name: H(2)O + amicyanin + methylamine = 2 H(+) + NH(3) + formaldehyde + reduced amicyanin namespace: reaction xref: KEGG:R00606 "KEGG reaction" xref: METACYC:RXN-2841 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:30210 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00218 ! methylamine relationship: has_input_compound UPa:UPC00218 {cardinality="1"} ! methylamine relationship: has_input_compound UPa:UPC19671 ! amicyanin relationship: has_input_compound UPa:UPC19671 {cardinality="1"} ! amicyanin relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_output_compound UPa:UPC00067 ! formaldehyde relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC19672 ! reduced amicyanin relationship: has_output_compound UPa:UPC19672 {cardinality="1"} ! reduced amicyanin relationship: part_of UPa:UER00870 {cardinality="1", direction="LR", order="1"} ! formaldehyde from methylamine: step 1/1 relationship: part_of UPa:UER00870 ! formaldehyde from methylamine: step 1/1 [Term] id: UPa:UCR00611 name: H(2)O + electron-transferring flavoprotein + sarcosine = formaldehyde + glycine + reduced electron-transferring flavoprotein namespace: reaction xref: KEGG:R00611 "KEGG reaction" xref: METACYC:SARCOSINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19796 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: has_input_compound UPa:UPC00213 ! sarcosine relationship: has_input_compound UPa:UPC04253 ! electron-transferring flavoprotein relationship: has_input_compound UPa:UPC04253 {cardinality="1"} ! electron-transferring flavoprotein relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00067 ! formaldehyde relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_output_compound UPa:UPC04570 {cardinality="1"} ! reduced electron-transferring flavoprotein relationship: has_output_compound UPa:UPC04570 ! reduced electron-transferring flavoprotein relationship: part_of UPa:UER00398 {cardinality="1", direction="LR", order="1"} ! formaldehyde and glycine from sarcosine: step 1/1 relationship: part_of UPa:UER00398 ! formaldehyde and glycine from sarcosine: step 1/1 [Term] id: UPa:UCR00617 name: ATP + thiamine phosphate = ADP + thiamine diphosphate namespace: reaction xref: KEGG:R00617 "KEGG reaction" xref: METACYC:THI-P-KIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15916 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01081 ! thiamine phosphate relationship: has_input_compound UPa:UPC01081 {cardinality="1"} ! thiamine phosphate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00068 ! thiamine diphosphate relationship: has_output_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate relationship: part_of UPa:UER00142 {cardinality="1", direction="LR", order="1"} ! thiamine diphosphate from thiamine phosphate: step 1/1 relationship: part_of UPa:UER00142 ! thiamine diphosphate from thiamine phosphate: step 1/1 [Term] id: UPa:UCR00619 name: ATP + thiamine = AMP + thiamine diphosphate namespace: reaction xref: KEGG:R00619 "KEGG reaction" xref: METACYC:THIAMIN-PYROPHOSPHOKINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11579 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00378 {cardinality="1"} ! thiamine relationship: has_input_compound UPa:UPC00378 ! thiamine relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00068 ! thiamine diphosphate relationship: has_output_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate relationship: part_of UPa:UER00597 ! thiamine diphosphate from thiamine: step 1/1 relationship: part_of UPa:UER00597 {cardinality="1", direction="LR", order="1"} ! thiamine diphosphate from thiamine: step 1/1 [Term] id: UPa:UCR00640 name: L-Galactono-1,4-lactone + 2 ferricytochrome c = 2 H(+) + L-ascorbate + 2 ferrocytochrome c namespace: reaction xref: KEGG:R00640 "KEGG reaction" xref: METACYC:GALACTONOLACTONE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14760 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c relationship: has_input_compound UPa:UPC00125 ! ferricytochrome c relationship: has_input_compound UPa:UPC01115 {cardinality="1"} ! L-Galactono-1,4-lactone relationship: has_input_compound UPa:UPC01115 ! L-Galactono-1,4-lactone relationship: has_output_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_output_compound UPa:UPC00072 ! L-ascorbate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c relationship: has_output_compound UPa:UPC00126 ! ferrocytochrome c relationship: part_of UPa:UER00935 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from GDP-alpha-D-mannose: step 5/5 relationship: part_of UPa:UER00935 ! L-ascorbate from GDP-alpha-D-mannose: step 5/5 [Term] id: UPa:UCR00647 name: L-ascorbate = L-xylo-hexulonolactone namespace: reaction xref: KEGG:R00647 "KEGG reaction" xref: METACYC:RXN-8784 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15272 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00072 ! L-ascorbate relationship: has_input_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_output_compound UPa:UPC03289 {cardinality="1"} ! L-xylo-hexulonolactone relationship: has_output_compound UPa:UPC03289 ! L-xylo-hexulonolactone relationship: part_of UPa:UER00939 {cardinality="1", direction="RL", order="2"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 4/4 relationship: part_of UPa:UER00939 ! L-ascorbate from UDP-alpha-D-glucuronate: step 4/4 [Term] id: UPa:UCR00658 name: 2-phospho-D-glycerate = H(2)O + phosphoenolpyruvate namespace: reaction xref: KEGG:R00658 "KEGG reaction" xref: METACYC:2PGADEHYDRAT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10167 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00631 {cardinality="1"} ! 2-phospho-D-glycerate relationship: has_input_compound UPa:UPC00631 ! 2-phospho-D-glycerate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_output_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: part_of UPa:UER00187 {cardinality="1", direction="LR", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 4/5 relationship: part_of UPa:UER00187 ! pyruvate from D-glyceraldehyde 3-phosphate: step 4/5 [Term] id: UPa:UCR00667 name: 2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde namespace: reaction xref: KEGG:R00667 "KEGG reaction" xref: METACYC:ORNITHINE-GLU-AMINOTRANSFORASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25163 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC01165 ! L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC01165 {cardinality="1"} ! L-glutamate 5-semialdehyde relationship: part_of UPa:UER00358 ! L-glutamate 5-semialdehyde from L-ornithine: step 1/1 relationship: part_of UPa:UER00358 {cardinality="1", direction="LR", order="1"} ! L-glutamate 5-semialdehyde from L-ornithine: step 1/1 [Term] id: UPa:UCR00669 name: H(2)O + N(2)-acetyl-L-ornithine = L-ornithine + acetate namespace: reaction xref: KEGG:R00669 "KEGG reaction" xref: METACYC:ACETYLORNDEACET-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15944 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00437 {cardinality="1"} ! N(2)-acetyl-L-ornithine relationship: has_input_compound UPa:UPC00437 ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00077 ! L-ornithine relationship: part_of UPa:UER00110 {cardinality="1", direction="LR", order="1"} ! L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1 relationship: part_of UPa:UER00110 ! L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1 [Term] id: UPa:UCR00670 name: L-ornithine = CO(2) + putrescine namespace: reaction xref: KEGG:R00670 "KEGG reaction" xref: METACYC:ORNDECARBOX-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22967 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: part_of UPa:UER00288 {cardinality="1", direction="LR", order="1"} ! putrescine from L-ornithine: step 1/1 relationship: part_of UPa:UER00288 ! putrescine from L-ornithine: step 1/1 [Term] id: UPa:UCR00671 name: L-ornithine = L-proline + NH(3) namespace: reaction xref: KEGG:R00671 "KEGG reaction" xref: METACYC:ORNITHINE-CYCLODEAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24371 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00148 ! L-proline relationship: has_output_compound UPa:UPC00148 {cardinality="1"} ! L-proline relationship: part_of UPa:UER00357 ! L-proline from L-ornithine: step 1/1 relationship: part_of UPa:UER00357 {cardinality="1", direction="LR", order="1"} ! L-proline from L-ornithine: step 1/1 [Term] id: UPa:UCR00673 name: H(2)O + L-tryptophan = NH(3) + indole + pyruvate namespace: reaction xref: KEGG:R00673 "KEGG reaction" xref: METACYC:TRYPTOPHAN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19556 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan relationship: has_input_compound UPa:UPC00078 ! L-tryptophan relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00463 {cardinality="1"} ! indole relationship: has_output_compound UPa:UPC00463 ! indole relationship: part_of UPa:UER00452 {cardinality="1", direction="LR", order="1"} ! indole and pyruvate from L-tryptophan: step 1/1 relationship: part_of UPa:UER00452 ! indole and pyruvate from L-tryptophan: step 1/1 [Term] id: UPa:UCR00674 name: L-serine + indole = H(2)O + L-tryptophan namespace: reaction xref: KEGG:R00674 "KEGG reaction" xref: METACYC:RXN0-2382 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26437 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC00463 {cardinality="1"} ! indole relationship: has_input_compound UPa:UPC00463 ! indole relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00078 ! L-tryptophan relationship: has_output_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan relationship: part_of UPa:UER00044 ! L-tryptophan from chorismate: step 5/5 relationship: part_of UPa:UER00044 {cardinality="1", direction="LR", order="2"} ! L-tryptophan from chorismate: step 5/5 [Term] id: UPa:UCR00678 name: L-tryptophan + O(2) = N-formyl-N-kynurenine namespace: reaction xref: KEGG:R00678 "KEGG reaction" xref: METACYC:RXN-8665 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24539 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00078 ! L-tryptophan relationship: has_input_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan relationship: has_output_compound UPa:UPC02700 ! N-formyl-N-kynurenine relationship: has_output_compound UPa:UPC02700 {cardinality="1"} ! N-formyl-N-kynurenine relationship: part_of UPa:UER00453 {cardinality="1", direction="LR", order="1"} ! L-kynurenine from L-tryptophan: step 1/2 relationship: part_of UPa:UER00453 ! L-kynurenine from L-tryptophan: step 1/2 [Term] id: UPa:UCR00688 name: H(2)O + L-phenylalanine + NAD(+) = H(+) + NADH + NH(3) + phenylpyruvate namespace: reaction xref: KEGG:R00688 "KEGG reaction" xref: METACYC:PHENYLALANINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21411 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00166 {cardinality="1"} ! phenylpyruvate relationship: has_output_compound UPa:UPC00166 ! phenylpyruvate relationship: part_of UPa:UER00346 {cardinality="1", direction="RL", order="1"} ! L-phenylalanine from phenylpyruvate (PDH route): step 1/1 relationship: part_of UPa:UER00346 ! L-phenylalanine from phenylpyruvate (PDH route): step 1/1 [Term] id: UPa:UCR00691 name: L-arogenate = CO(2) + H(2)O + L-phenylalanine namespace: reaction xref: KEGG:R00691 "KEGG reaction" xref: METACYC:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12539 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00826 ! L-arogenate relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_output_compound UPa:UPC00079 ! L-phenylalanine relationship: part_of UPa:UER00344 ! L-phenylalanine from L-arogenate: step 1/1 relationship: part_of UPa:UER00344 {cardinality="1", direction="LR", order="1"} ! L-phenylalanine from L-arogenate: step 1/1 [Term] id: UPa:UCR00694 name: 2-oxoglutarate + L-phenylalanine = L-glutamate + phenylpyruvate namespace: reaction xref: KEGG:R00694 "KEGG reaction" xref: METACYC:PHEAMINOTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25155 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00166 ! phenylpyruvate relationship: has_output_compound UPa:UPC00166 {cardinality="1"} ! phenylpyruvate relationship: part_of UPa:UER00347 {cardinality="1", direction="RL", order="1"} ! L-phenylalanine from phenylpyruvate (ArAT route): step 1/1 relationship: part_of UPa:UER00347 ! L-phenylalanine from phenylpyruvate (ArAT route): step 1/1 [Term] id: UPa:UCR00697 name: L-phenylalanine = NH(3) + trans-cinnamate namespace: reaction xref: KEGG:R00697 "KEGG reaction" xref: METACYC:PHENYLALANINE-AMMONIA-LYASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21387 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00423 {cardinality="1"} ! trans-cinnamate relationship: has_output_compound UPa:UPC00423 ! trans-cinnamate relationship: part_of UPa:UER00725 ! trans-cinnamate from L-phenylalanine: step 1/1 relationship: part_of UPa:UER00725 {cardinality="1", direction="LR", order="1"} ! trans-cinnamate from L-phenylalanine: step 1/1 [Term] id: UPa:UCR00699 name: L-phenylalanine = 2-phenylethylamine + CO(2) namespace: reaction xref: KEGG:R00699 "KEGG reaction" xref: METACYC:PHENYLALANINE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19720 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC05332 {cardinality="1"} ! 2-phenylethylamine relationship: has_output_compound UPa:UPC05332 ! 2-phenylethylamine relationship: part_of UPa:UER00722 {cardinality="1", direction="LR", order="1"} ! phenylacetate from L-phenylalanine: step 1/3 relationship: part_of UPa:UER00722 ! phenylacetate from L-phenylalanine: step 1/3 [Term] id: UPa:UCR00703 name: (S)-lactate + NAD(+) = H(+) + NADH + pyruvate namespace: reaction xref: KEGG:R00703 "KEGG reaction" xref: METACYC:L-LACTATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23447 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00186 {cardinality="1"} ! (S)-lactate relationship: has_input_compound UPa:UPC00186 ! (S)-lactate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:UER00611 {cardinality="1", direction="RL", order="1"} ! (S)-lactate from pyruvate: step 1/1 relationship: part_of UPa:UER00611 ! (S)-lactate from pyruvate: step 1/1 [Term] id: UPa:UCR00705 name: 3-oxopropanoate + CoA + NAD(+) = CO(2) + H(+) + NADH + acetyl-CoA namespace: reaction xref: KEGG:R00705 "KEGG reaction" xref: METACYC:RXN-2902 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22995 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00222 {cardinality="1"} ! 3-oxopropanoate relationship: has_input_compound UPa:UPC00222 ! 3-oxopropanoate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:UER00951 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00951 ! None [Term] id: UPa:UCR00706 name: 3-oxopropanoate + CoA + NADP(+) = CO(2) + H(+) + NADPH + acetyl-CoA namespace: reaction xref: KEGG:R00706 "KEGG reaction" xref: METACYC:1.2.1.18-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22991 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00222 {cardinality="1"} ! 3-oxopropanoate relationship: has_input_compound UPa:UPC00222 ! 3-oxopropanoate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:UER00952 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00952 ! None [Term] id: UPa:UCR00707 name: (S)-1-pyrroline-5-carboxylic acid + 2 H(2)O + NAD(+) = H(+) + L-glutamate + NADH namespace: reaction xref: KEGG:R00707 "KEGG reaction" xref: METACYC:PYRROLINECARBDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: METACYC:RXN-11632 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:16420 "Rhea reaction" xref: RHEA:24893 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC03912 ! (S)-1-pyrroline-5-carboxylic acid relationship: has_input_compound UPa:UPC03912 {cardinality="1"} ! (S)-1-pyrroline-5-carboxylic acid relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:UER00374 ! L-glutamate from L-proline: step 2/2 relationship: part_of UPa:UER00374 {cardinality="1", direction="LR", order="1"} ! L-glutamate from L-proline: step 2/2 [Term] id: UPa:UCR00709 name: NAD(+) + isocitrate = 2-oxoglutarate + CO(2) + H(+) + NADH namespace: reaction xref: KEGG:R00709 "KEGG reaction" xref: METACYC:ISOCITRATE-DEHYDROGENASE-NAD+-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: METACYC:RXN-7969 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:23635 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate relationship: has_input_compound UPa:UPC00311 ! isocitrate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00996 {cardinality="1", direction="LR", order="1"} ! 2-oxoglutarate from isocitrate (NAD(+) route): step 1/1 relationship: part_of UPa:UER00996 ! 2-oxoglutarate from isocitrate (NAD(+) route): step 1/1 [Term] id: UPa:UCR00710 name: H(2)O + NAD(+) + acetaldehyde = H(+) + NADH + acetate namespace: reaction xref: KEGG:R00710 "KEGG reaction" xref: METACYC:RXN66-3 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25297 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_input_compound UPa:UPC00084 ! acetaldehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00768 {cardinality="1", direction="LR", order="1"} ! acetate from ethanol: step 2/2 relationship: part_of UPa:UER00768 ! acetate from ethanol: step 2/2 [Term] id: UPa:UCR00713 name: H(2)O + NAD(+) + succinate semialdehyde = H(+) + NADH + succinate namespace: reaction xref: KEGG:R00713 "KEGG reaction" xref: METACYC:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13220 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde relationship: has_input_compound UPa:UPC00232 ! succinate semialdehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER01003 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER01003 ! None [Term] id: UPa:UCR00714 name: H(2)O + NADP(+) + succinate semialdehyde = H(+) + NADPH + succinate namespace: reaction xref: KEGG:R00714 "KEGG reaction" xref: METACYC:SUCCSEMIALDDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13216 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00232 ! succinate semialdehyde relationship: has_input_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER01004 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER01004 ! None [Term] id: UPa:UCR00715 name: H(2)O + NAD(+) + saccharopine = 2-oxoglutarate + H(+) + L-lysine + NADH namespace: reaction xref: KEGG:R00715 "KEGG reaction" xref: METACYC:1.5.1.7-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12443 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00449 ! saccharopine relationship: has_input_compound UPa:UPC00449 {cardinality="1"} ! saccharopine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00034 ! L-lysine from L-alpha-aminoadipate (fungal route): step 3/3 relationship: part_of UPa:UER00034 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 3/3 [Term] id: UPa:UCR00716 name: H(2)O + NADP(+) + saccharopine = 2-oxoglutarate + H(+) + L-lysine + NADPH namespace: reaction xref: KEGG:R00716 "KEGG reaction" xref: METACYC:1.5.1.8-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19376 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00449 ! saccharopine relationship: has_input_compound UPa:UPC00449 {cardinality="1"} ! saccharopine relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00835 {cardinality="1", direction="RL", order="1"} ! glutaryl-CoA from L-lysine: step 1/6 relationship: part_of UPa:UER00835 ! glutaryl-CoA from L-lysine: step 1/6 [Term] id: UPa:UCR00731 name: L-tyrosine + O(2) = H(2)O + L-dopa namespace: reaction xref: KEGG:R00731 "KEGG reaction" xref: RHEA:34286 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00082 ! L-tyrosine relationship: has_input_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00355 {cardinality="1"} ! L-dopa relationship: has_output_compound UPa:UPC00355 ! L-dopa relationship: part_of UPa:UER00733 {cardinality="1", direction="LR", order="1"} ! dopamine from L-tyrosine: step 1/2 relationship: part_of UPa:UER00733 ! dopamine from L-tyrosine: step 1/2 [Term] id: UPa:UCR00732 name: L-arogenate + NAD(+) = CO(2) + H(+) + L-tyrosine + NADH namespace: reaction xref: KEGG:R00732 "KEGG reaction" xref: METACYC:CYCLOHEXADIENYL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12259 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_input_compound UPa:UPC00826 ! L-arogenate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: part_of UPa:UER00959 ! L-tyrosine from L-arogenate (NAD(+) route): step 1/1 relationship: part_of UPa:UER00959 {cardinality="1", direction="LR", order="1"} ! L-tyrosine from L-arogenate (NAD(+) route): step 1/1 [Term] id: UPa:UCR00733 name: L-arogenate + NADP(+) = CO(2) + H(+) + L-tyrosine + NADPH namespace: reaction xref: KEGG:R00733 "KEGG reaction" xref: METACYC:RXN-5682 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15420 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_input_compound UPa:UPC00826 ! L-arogenate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: part_of UPa:UER00960 ! L-tyrosine from L-arogenate (NADP(+) route): step 1/1 relationship: part_of UPa:UER00960 {cardinality="1", direction="LR", order="1"} ! L-tyrosine from L-arogenate (NADP(+) route): step 1/1 [Term] id: UPa:UCR00734 name: 2-oxoglutarate + L-tyrosine = (4-hydroxyphenyl)pyruvate + L-glutamate namespace: reaction xref: KEGG:R00734 "KEGG reaction" xref: METACYC:TYROSINE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15096 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: has_input_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate relationship: part_of UPa:UER00338 ! acetoacetate and fumarate from L-phenylalanine: step 2/6 relationship: part_of UPa:UER00338 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 2/6 relationship: part_of UPa:UER00350 ! L-tyrosine from (4-hydroxyphenyl)pyruvate: step 1/1 relationship: part_of UPa:UER00350 {cardinality="1", direction="RL", order="1"} ! L-tyrosine from (4-hydroxyphenyl)pyruvate: step 1/1 [Term] id: UPa:UCR00742 name: ATP + acetyl-CoA + bicarbonate = ADP + malonyl-CoA + phosphate namespace: reaction xref: KEGG:R00742 "KEGG reaction" xref: METACYC:ACETYL-COA-CARBOXYLTRANSFER-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11311 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00083 {cardinality="1"} ! malonyl-CoA relationship: has_output_compound UPa:UPC00083 ! malonyl-CoA relationship: part_of UPa:UER00711 ! malonyl-CoA from acetyl-CoA: step 1/1 relationship: part_of UPa:UER00711 {cardinality="1", direction="LR", order="1"} ! malonyl-CoA from acetyl-CoA: step 1/1 [Term] id: UPa:UCR00750 name: acetaldehyde + pyruvate = 4-hydroxy-2-oxopentanoate namespace: reaction xref: KEGG:R00750 "KEGG reaction" xref: METACYC:MHPELY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22627 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00084 ! acetaldehyde relationship: has_input_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC03589 {cardinality="1"} ! 4-hydroxy-2-oxopentanoate relationship: has_output_compound UPa:UPC03589 ! 4-hydroxy-2-oxopentanoate relationship: part_of UPa:UER00797 {cardinality="1", direction="RL", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 4/4 relationship: part_of UPa:UER00797 ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 4/4 relationship: part_of UPa:UER00907 ! acetaldehyde and pyruvate from p-cumate: step 7/7 relationship: part_of UPa:UER00907 {cardinality="1", direction="RL", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 7/7 [Term] id: UPa:UCR00751 name: L-threonine = acetaldehyde + glycine namespace: reaction xref: KEGG:R00751 "KEGG reaction" xref: METACYC:THREONINE-ALDOLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19628 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00188 ! L-threonine relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: part_of UPa:UER00429 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and glycine from L-threonine: step 1/1 relationship: part_of UPa:UER00429 ! acetaldehyde and glycine from L-threonine: step 1/1 [Term] id: UPa:UCR00754 name: NAD(+) + ethanol = H(+) + NADH + acetaldehyde namespace: reaction xref: KEGG:R00754 "KEGG reaction" xref: METACYC:ALCOHOL-DEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25293 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00469 {cardinality="1"} ! ethanol relationship: has_input_compound UPa:UPC00469 ! ethanol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: part_of UPa:UER00767 {cardinality="1", direction="LR", order="1"} ! acetate from ethanol: step 1/2 relationship: part_of UPa:UER00767 ! acetate from ethanol: step 1/2 [Term] id: UPa:UCR00756 name: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate namespace: reaction xref: KEGG:R00756 "KEGG reaction" xref: METACYC:6PFRUCTPHOS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16112 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00354 {cardinality="1"} ! D-fructose 1,6-bisphosphate relationship: has_output_compound UPa:UPC00354 ! D-fructose 1,6-bisphosphate relationship: part_of UPa:UER00182 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4 relationship: part_of UPa:UER00182 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4 [Term] id: UPa:UCR00765 name: H(2)O + alpha-D-glucosamine 6-phosphate = D-fructose 6-phosphate + NH(3) namespace: reaction xref: KEGG:R00765 "KEGG reaction" xref: METACYC:GLUCOSAMINE-6-P-DEAMIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12175 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: has_input_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: part_of UPa:UER00684 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 5/5 relationship: part_of UPa:UER00684 ! D-fructose 6-phosphate from N-acetylneuraminate: step 5/5 [Term] id: UPa:UCR00766 name: D-fructose 6-phosphate + UDP-alpha-D-glucose = UDP + sucrose 6-phosphate namespace: reaction xref: KEGG:R00766 "KEGG reaction" xref: METACYC:SUCROSE-PHOSPHATE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22175 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00029 ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC00029 {cardinality="1"} ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC02591 ! sucrose 6-phosphate relationship: has_output_compound UPa:UPC02591 {cardinality="1"} ! sucrose 6-phosphate relationship: part_of UPa:UER00545 {cardinality="1", direction="LR", order="1"} ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 1/2 relationship: part_of UPa:UER00545 ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 1/2 [Term] id: UPa:UCR00768 name: D-fructose 6-phosphate + L-glutamine = L-glutamate + alpha-D-glucosamine 6-phosphate namespace: reaction xref: KEGG:R00768 "KEGG reaction" xref: METACYC:L-GLN-FRUCT-6-P-AMINOTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13240 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: part_of UPa:UER00528 {cardinality="1", direction="LR", order="1"} ! alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1 relationship: part_of UPa:UER00528 ! alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1 [Term] id: UPa:UCR00771 name: D-glucose 6-phosphate = D-fructose 6-phosphate namespace: reaction xref: KEGG:R00771 "KEGG reaction" xref: METACYC:PGLUCISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: METACYC:RXN-6182 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:11819 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: part_of UPa:UER00181 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4 relationship: part_of UPa:UER00181 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4 [Term] id: UPa:UCR00772 name: D-mannose 6-phosphate = D-fructose 6-phosphate namespace: reaction xref: KEGG:R00772 "KEGG reaction" xref: METACYC:MANNPISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12359 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00275 {cardinality="1"} ! D-mannose 6-phosphate relationship: has_input_compound UPa:UPC00275 ! D-mannose 6-phosphate relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: part_of UPa:UER00423 {cardinality="1", direction="RL", order="1"} ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2 relationship: part_of UPa:UER00423 ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2 [Term] id: UPa:UCR00774 name: ATP + bicarbonate + urea = ADP + phosphate + urea-1-carboxylate namespace: reaction xref: KEGG:R00774 "KEGG reaction" xref: METACYC:UREA-CARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20899 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00086 ! urea relationship: has_input_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC01010 ! urea-1-carboxylate relationship: has_output_compound UPa:UPC01010 {cardinality="1"} ! urea-1-carboxylate relationship: part_of UPa:UER00371 ! CO(2) and NH(3) from urea (allophanate route): step 1/2 relationship: part_of UPa:UER00371 {cardinality="1", direction="LR", order="1"} ! CO(2) and NH(3) from urea (allophanate route): step 1/2 [Term] id: UPa:UCR00783 name: H(2)O + ferricytochrome c + nitric oxide = H(+) + ferrocytochrome c + nitrite namespace: reaction xref: KEGG:R00783 "KEGG reaction" xref: METACYC:NITRITE-REDUCTASE-CYTOCHROME-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:15236 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c relationship: has_input_compound UPa:UPC00125 ! ferricytochrome c relationship: has_input_compound UPa:UPC00533 ! nitric oxide relationship: has_input_compound UPa:UPC00533 {cardinality="1"} ! nitric oxide relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00088 {cardinality="1"} ! nitrite relationship: has_output_compound UPa:UPC00088 ! nitrite relationship: has_output_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c relationship: has_output_compound UPa:UPC00126 ! ferrocytochrome c relationship: part_of UPa:UER00707 ! dinitrogen from nitrate: step 2/4 relationship: part_of UPa:UER00707 {cardinality="1", direction="RL", order="1"} ! dinitrogen from nitrate: step 2/4 [Term] id: UPa:UCR00798 name: H(2)O + acceptor + nitrite = nitrate + reduced acceptor namespace: reaction xref: KEGG:R00798 "KEGG reaction" xref: METACYC:NITRATREDUCT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21071 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00088 ! nitrite relationship: has_input_compound UPa:UPC00088 {cardinality="1"} ! nitrite relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00244 {cardinality="1"} ! nitrate relationship: has_output_compound UPa:UPC00244 ! nitrate relationship: part_of UPa:UER00706 ! dinitrogen from nitrate: step 1/4 relationship: part_of UPa:UER00706 {cardinality="1", direction="RL", order="1"} ! dinitrogen from nitrate: step 1/4 [Term] id: UPa:UCR00805 name: H(2)O + sucrose 6-phosphate = phosphate + sucrose namespace: reaction xref: KEGG:R00805 "KEGG reaction" xref: METACYC:SUCROSE-PHOSPHATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19292 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC02591 ! sucrose 6-phosphate relationship: has_input_compound UPa:UPC02591 {cardinality="1"} ! sucrose 6-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00089 ! sucrose relationship: has_output_compound UPa:UPC00089 {cardinality="1"} ! sucrose relationship: part_of UPa:UER00546 {cardinality="1", direction="LR", order="1"} ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 2/2 relationship: part_of UPa:UER00546 ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 2/2 [Term] id: UPa:UCR00812 name: NAD(+) + cis-1,2-dihydrobenzene-1,2-diol = H(+) + NADH + catechol namespace: reaction xref: KEGG:R00812 "KEGG reaction" xref: METACYC:1.3.1.19-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15460 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC04091 {cardinality="1"} ! cis-1,2-dihydrobenzene-1,2-diol relationship: has_input_compound UPa:UPC04091 ! cis-1,2-dihydrobenzene-1,2-diol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: has_output_compound UPa:UPC00090 ! catechol relationship: part_of UPa:UER00392 ! catechol from benzene: step 2/2 relationship: part_of UPa:UER00392 {cardinality="1", direction="LR", order="1"} ! catechol from benzene: step 2/2 [Term] id: UPa:UCR00813 name: (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid + NAD(+) = CO(2) + H(+) + NADH + catechol namespace: reaction xref: KEGG:R00813 "KEGG reaction" xref: METACYC:1.3.1.25-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11563 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC06321 {cardinality="1"} ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid relationship: has_input_compound UPa:UPC06321 ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: has_output_compound UPa:UPC00090 ! catechol relationship: part_of UPa:UER00255 ! catechol from benzoate: step 2/2 relationship: part_of UPa:UER00255 {cardinality="1", direction="LR", order="1"} ! catechol from benzoate: step 2/2 [Term] id: UPa:UCR00817 name: O(2) + catechol = cis,cis-muconate namespace: reaction xref: KEGG:R00817 "KEGG reaction" xref: METACYC:CATECHOL-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23855 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00090 ! catechol relationship: has_input_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: has_output_compound UPa:UPC02480 ! cis,cis-muconate relationship: has_output_compound UPa:UPC02480 {cardinality="1"} ! cis,cis-muconate relationship: part_of UPa:UER00258 {cardinality="1", direction="LR", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 1/3 relationship: part_of UPa:UER00258 ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 1/3 [Term] id: UPa:UCR00823 name: H(+) + NADH + O(2) + anthranilate = CO(2) + NAD(+) + NH(3) + catechol namespace: reaction xref: KEGG:R00823 "KEGG reaction" xref: RHEA:11079 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00108 ! anthranilate relationship: has_input_compound UPa:UPC00108 {cardinality="1"} ! anthranilate relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: has_output_compound UPa:UPC00090 ! catechol relationship: part_of UPa:UER01026 ! catechol from anthranilate: step 1/1 relationship: part_of UPa:UER01026 {cardinality="1", direction="LR", order="1"} ! catechol from anthranilate: step 1/1 [Term] id: UPa:UCR00829 name: acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA namespace: reaction xref: KEGG:R00829 "KEGG reaction" xref: METACYC:RXN-3641 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19484 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC02232 ! 3-oxoadipyl-CoA relationship: has_output_compound UPa:UPC02232 {cardinality="1"} ! 3-oxoadipyl-CoA relationship: part_of UPa:UER00263 ! acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 2/2 relationship: part_of UPa:UER00263 {cardinality="1", direction="RL", order="1"} ! acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 2/2 [Term] id: UPa:UCR00830 name: glycine + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA namespace: reaction xref: KEGG:R00830 "KEGG reaction" xref: METACYC:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12924 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00430 ! 5-aminolevulinate relationship: has_output_compound UPa:UPC00430 {cardinality="1"} ! 5-aminolevulinate relationship: part_of UPa:UER00375 ! 5-aminolevulinate from glycine: step 1/1 relationship: part_of UPa:UER00375 {cardinality="1", direction="LR", order="1"} ! 5-aminolevulinate from glycine: step 1/1 [Term] id: UPa:UCR00832 name: L-arginine + succinyl-CoA = CoA + N(2)-succinyl-L-arginine namespace: reaction xref: KEGG:R00832 "KEGG reaction" xref: METACYC:ARGININE-N-SUCCINYLTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15188 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC03296 {cardinality="1"} ! N(2)-succinyl-L-arginine relationship: has_output_compound UPa:UPC03296 ! N(2)-succinyl-L-arginine relationship: part_of UPa:UER00279 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 1/5 relationship: part_of UPa:UER00279 ! L-glutamate and succinate from L-arginine: step 1/5 [Term] id: UPa:UCR00833 name: (R)-methylmalonyl-CoA = succinyl-CoA namespace: reaction xref: KEGG:R00833 "KEGG reaction" xref: METACYC:METHYLMALONYL-COA-MUT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22891 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01213 {cardinality="1"} ! (R)-methylmalonyl-CoA relationship: has_input_compound UPa:UPC01213 ! (R)-methylmalonyl-CoA relationship: has_output_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: part_of UPa:UER00910 {cardinality="1", direction="LR", order="1"} ! succinyl-CoA from propanoyl-CoA: step 3/3 relationship: part_of UPa:UER00910 ! succinyl-CoA from propanoyl-CoA: step 3/3 [Term] id: UPa:UCR00835 name: D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + H(+) + NADPH namespace: reaction xref: KEGG:R00835 "KEGG reaction" xref: METACYC:RXN-14819 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:15844 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01236 ! D-glucono-1,5-lactone 6-phosphate relationship: has_output_compound UPa:UPC01236 {cardinality="1"} ! D-glucono-1,5-lactone 6-phosphate relationship: part_of UPa:UER00408 {cardinality="1", direction="LR", order="1"} ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3 relationship: part_of UPa:UER00408 ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3 [Term] id: UPa:UCR00847 name: ATP + glycerol = ADP + sn-glycerol 3-phosphate namespace: reaction xref: KEGG:R00847 "KEGG reaction" xref: METACYC:GLYCEROL-KIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21647 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00116 ! glycerol relationship: has_input_compound UPa:UPC00116 {cardinality="1"} ! glycerol relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: part_of UPa:UER00672 ! sn-glycerol 3-phosphate from glycerol: step 1/1 relationship: part_of UPa:UER00672 {cardinality="1", direction="LR", order="1"} ! sn-glycerol 3-phosphate from glycerol: step 1/1 [Term] id: UPa:UCR00849 name: Quinone + sn-glycerol 3-phosphate = Hydroquinone + glycerone phosphate namespace: reaction xref: KEGG:R00849 "KEGG reaction" xref: RHEA:18980 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone relationship: has_input_compound UPa:UPC15602 ! Quinone relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone relationship: has_output_compound UPa:UPC15603 ! Hydroquinone relationship: part_of UPa:UER00673 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1 relationship: part_of UPa:UER00673 ! glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1 relationship: part_of UPa:UER00674 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1 relationship: part_of UPa:UER00674 ! glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1 [Term] id: UPa:UCR00851 name: acyl-CoA + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + CoA namespace: reaction xref: KEGG:R00851 "KEGG reaction" xref: METACYC:RXN-1381 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15328 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00040 {cardinality="1"} ! acyl-CoA relationship: has_input_compound UPa:UPC00040 ! acyl-CoA relationship: has_input_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00681 {cardinality="1"} ! 1-acyl-sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00681 ! 1-acyl-sn-glycerol 3-phosphate relationship: part_of UPa:UER00612 {cardinality="1", direction="LR", order="1"} ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3 relationship: part_of UPa:UER00612 ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3 [Term] id: UPa:UCR00858 name: 3 H(2)O + 3 NADP(+) + hydrogen sulfide = 3 H(+) + 3 NADPH + sulfite namespace: reaction xref: KEGG:R00858 "KEGG reaction" xref: METACYC:SULFITE-REDUCT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13804 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: part_of UPa:UER00207 ! hydrogen sulfide from sulfite (NADPH route): step 1/1 relationship: part_of UPa:UER00207 {cardinality="1", direction="RL", order="1"} ! hydrogen sulfide from sulfite (NADPH route): step 1/1 [Term] id: UPa:UCR00859 name: 3 H(2)O + hydrogen sulfide + 6 oxidized ferredoxin = 6 H(+) + 6 reduced ferredoxin + sulfite namespace: reaction xref: KEGG:R00859 "KEGG reaction" xref: METACYC:SULFITE-REDUCTASE-FERREDOXIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23135 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00139 ! oxidized ferredoxin relationship: has_input_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_output_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin relationship: has_output_compound UPa:UPC00138 ! reduced ferredoxin relationship: part_of UPa:UER00208 ! hydrogen sulfide from sulfite (ferredoxin route): step 1/1 relationship: part_of UPa:UER00208 {cardinality="1", direction="RL", order="1"} ! hydrogen sulfide from sulfite (ferredoxin route): step 1/1 [Term] id: UPa:UCR00874 name: D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol namespace: reaction xref: KEGG:R00874 "KEGG reaction" xref: METACYC:1.1.99.28-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20640 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00031 ! D-glucose relationship: has_input_compound UPa:UPC00031 {cardinality="1"} ! D-glucose relationship: has_input_compound UPa:UPC00095 ! D-fructose relationship: has_input_compound UPa:UPC00095 {cardinality="1"} ! D-fructose relationship: has_output_compound UPa:UPC00198 {cardinality="1"} ! D-glucono-1,5-lactone relationship: has_output_compound UPa:UPC00198 ! D-glucono-1,5-lactone relationship: has_output_compound UPa:UPC00794 ! D-sorbitol relationship: has_output_compound UPa:UPC00794 {cardinality="1"} ! D-sorbitol relationship: part_of UPa:UER00784 {cardinality="1", direction="LR", order="1"} ! D-sorbitol from D-fructose and D-glucose: step 1/1 relationship: part_of UPa:UER00784 ! D-sorbitol from D-fructose and D-glucose: step 1/1 [Term] id: UPa:UCR00883 name: GDP + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + phosphate namespace: reaction xref: KEGG:R00883 "KEGG reaction" xref: METACYC:MANNPGUANYLTRANGDP-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12908 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00035 ! GDP relationship: has_input_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_input_compound UPa:UPC00636 {cardinality="1"} ! alpha-D-mannose 1-phosphate relationship: has_input_compound UPa:UPC00636 ! alpha-D-mannose 1-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: part_of UPa:UER00425 {cardinality="1", direction="LR", order="1"} ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GDP route): step 1/1 relationship: part_of UPa:UER00425 ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GDP route): step 1/1 [Term] id: UPa:UCR00885 name: GTP + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + diphosphate namespace: reaction xref: KEGG:R00885 "KEGG reaction" xref: METACYC:2.7.7.13-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15232 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC00636 {cardinality="1"} ! alpha-D-mannose 1-phosphate relationship: has_input_compound UPa:UPC00636 ! alpha-D-mannose 1-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: part_of UPa:UER00930 ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1 relationship: part_of UPa:UER00930 {cardinality="1", direction="LR", order="1"} ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1 [Term] id: UPa:UCR00888 name: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H(2)O namespace: reaction xref: KEGG:R00888 "KEGG reaction" xref: METACYC:GDPMANDEHYDRA-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23823 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC01222 {cardinality="1"} ! GDP-4-dehydro-6-deoxy-D-mannose relationship: has_output_compound UPa:UPC01222 ! GDP-4-dehydro-6-deoxy-D-mannose relationship: part_of UPa:UER00190 ! GDP-L-fucose from GDP-alpha-D-mannose: step 1/2 relationship: part_of UPa:UER00190 {cardinality="1", direction="LR", order="1"} ! GDP-L-fucose from GDP-alpha-D-mannose: step 1/2 [Term] id: UPa:UCR00893 name: L-cysteine + O(2) = 3-sulfino-L-alanine namespace: reaction xref: KEGG:R00893 "KEGG reaction" xref: METACYC:CYSTEINE-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20444 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_output_compound UPa:UPC00606 {cardinality="1"} ! 3-sulfino-L-alanine relationship: has_output_compound UPa:UPC00606 ! 3-sulfino-L-alanine relationship: part_of UPa:UER00537 ! hypotaurine from L-cysteine: step 1/2 relationship: part_of UPa:UER00537 {cardinality="1", direction="LR", order="1"} ! hypotaurine from L-cysteine: step 1/2 [Term] id: UPa:UCR00894 name: ATP + L-cysteine + L-glutamate = ADP + L-gamma-glutamyl-L-cysteine + phosphate namespace: reaction xref: KEGG:R00894 "KEGG reaction" xref: METACYC:GLUTCYSLIG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13288 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00669 {cardinality="1"} ! L-gamma-glutamyl-L-cysteine relationship: has_output_compound UPa:UPC00669 ! L-gamma-glutamyl-L-cysteine relationship: part_of UPa:UER00209 ! glutathione from L-cysteine and L-glutamate: step 1/2 relationship: part_of UPa:UER00209 {cardinality="1", direction="LR", order="1"} ! glutathione from L-cysteine and L-glutamate: step 1/2 [Term] id: UPa:UCR00897 name: O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate namespace: reaction xref: KEGG:R00897 "KEGG reaction" xref: METACYC:ACSERLY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14832 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: has_input_compound UPa:UPC00979 ! O-acetyl-L-serine relationship: has_input_compound UPa:UPC00979 {cardinality="1"} ! O-acetyl-L-serine relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00097 ! L-cysteine relationship: has_output_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: part_of UPa:UER00200 ! L-cysteine from L-serine: step 2/2 relationship: part_of UPa:UER00200 {cardinality="1", direction="LR", order="1"} ! L-cysteine from L-serine: step 2/2 [Term] id: UPa:UCR00901 name: L-cysteine + sulfite = L-cysteate + hydrogen sulfide namespace: reaction xref: KEGG:R00901 "KEGG reaction" xref: METACYC:CYSTEINE-LYASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20919 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00094 ! sulfite relationship: has_input_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_output_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: has_output_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_output_compound UPa:UPC00506 ! L-cysteate relationship: has_output_compound UPa:UPC00506 {cardinality="1"} ! L-cysteate relationship: part_of UPa:UER00540 ! taurine from L-cysteine: step 1/2 relationship: part_of UPa:UER00540 {cardinality="1", direction="LR", order="1"} ! taurine from L-cysteine: step 1/2 [Term] id: UPa:UCR00921 name: phosphate + propanoyl-CoA = CoA + propanoyl phosphate namespace: reaction xref: KEGG:R00921 "KEGG reaction" xref: METACYC:PTAALT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28049 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00100 {cardinality="1"} ! propanoyl-CoA relationship: has_input_compound UPa:UPC00100 ! propanoyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC02876 {cardinality="1"} ! propanoyl phosphate relationship: has_output_compound UPa:UPC02876 ! propanoyl phosphate relationship: part_of UPa:UER00509 {cardinality="1", direction="LR", order="1"} ! propanoate from L-threonine: step 3/4 relationship: part_of UPa:UER00509 ! propanoate from L-threonine: step 3/4 [Term] id: UPa:UCR00939 name: 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH namespace: reaction xref: KEGG:R00939 "KEGG reaction" xref: METACYC:DIHYDROFOLATEREDUCT-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:15012 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00415 ! 7,8-dihydrofolate relationship: has_output_compound UPa:UPC00415 {cardinality="1"} ! 7,8-dihydrofolate relationship: part_of UPa:UER00158 ! 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1 relationship: part_of UPa:UER00158 {cardinality="1", direction="RL", order="1"} ! 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1 [Term] id: UPa:UCR00944 name: 10-formyl-5,6,7,8-tetrahydrofolate + H(2)O = 5,6,7,8-tetrahydrofolate + formate namespace: reaction xref: KEGG:R00944 "KEGG reaction" xref: METACYC:FORMYLTHFDEFORMYL-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19836 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00234 {cardinality="1"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00234 ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:UER00170 {cardinality="1", direction="LR", order="1"} ! formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1 relationship: part_of UPa:UER00170 ! formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1 [Term] id: UPa:UCR00945 name: 5,10-methylene-THF + H(2)O + glycine = 5,6,7,8-tetrahydrofolate + L-serine namespace: reaction xref: KEGG:R00945 "KEGG reaction" xref: METACYC:GLYOHMETRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15484 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00143 {cardinality="1"} ! 5,10-methylene-THF relationship: has_input_compound UPa:UPC00143 ! 5,10-methylene-THF relationship: has_output_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_output_compound UPa:UPC00065 ! L-serine relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:UER00914 ! 3-phospho-D-glycerate from glycine: step 1/4 relationship: part_of UPa:UER00914 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycine: step 1/4 relationship: part_of UPa:UER01023 ! glycine from L-serine: step 1/1 relationship: part_of UPa:UER01023 {cardinality="1", direction="RL", order="1"} ! glycine from L-serine: step 1/1 [Term] id: UPa:UCR00946 name: 5-methyl-THF + L-homocysteine = 5,6,7,8-tetrahydrofolate + L-methionine namespace: reaction xref: KEGG:R00946 "KEGG reaction" xref: METACYC:HOMOCYSMETB12-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11175 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_input_compound UPa:UPC00440 ! 5-methyl-THF relationship: has_input_compound UPa:UPC00440 {cardinality="1"} ! 5-methyl-THF relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:UER00081 ! L-methionine from L-homocysteine (MetH route): step 1/1 relationship: part_of UPa:UER00081 {cardinality="1", direction="LR", order="1"} ! L-methionine from L-homocysteine (MetH route): step 1/1 [Term] id: UPa:UCR00956 name: CTP + alpha-D-glucose 1-phosphate = CDP-glucose + diphosphate namespace: reaction xref: KEGG:R00956 "KEGG reaction" xref: METACYC:2.7.7.33-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18216 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00103 ! alpha-D-glucose 1-phosphate relationship: has_input_compound UPa:UPC00103 {cardinality="1"} ! alpha-D-glucose 1-phosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00501 {cardinality="1"} ! CDP-glucose relationship: has_output_compound UPa:UPC00501 ! CDP-glucose relationship: part_of UPa:UER00511 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 1/5 relationship: part_of UPa:UER00511 {cardinality="1", direction="LR", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 1/5 [Term] id: UPa:UCR00964 name: ATP + uridine = ADP + UMP namespace: reaction xref: KEGG:R00964 "KEGG reaction" xref: METACYC:URIDINEKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16828 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00299 {cardinality="1"} ! uridine relationship: has_input_compound UPa:UPC00299 ! uridine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00105 ! UMP relationship: has_output_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: part_of UPa:UER00637 {cardinality="1", direction="LR", order="1"} ! UMP from uridine: step 1/1 relationship: part_of UPa:UER00637 ! UMP from uridine: step 1/1 [Term] id: UPa:UCR00965 name: orotidine 5'-phosphate = CO(2) + UMP namespace: reaction xref: KEGG:R00965 "KEGG reaction" xref: METACYC:OROTPDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11599 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01103 {cardinality="1"} ! orotidine 5'-phosphate relationship: has_input_compound UPa:UPC01103 ! orotidine 5'-phosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00105 ! UMP relationship: has_output_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: part_of UPa:UER00120 ! UMP from orotate: step 2/2 relationship: part_of UPa:UER00120 {cardinality="1", direction="LR", order="1"} ! UMP from orotate: step 2/2 [Term] id: UPa:UCR00966 name: UMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + uracil namespace: reaction xref: KEGG:R00966 "KEGG reaction" xref: METACYC:URACIL-PRIBOSYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13020 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: has_input_compound UPa:UPC00105 ! UMP relationship: has_output_compound UPa:UPC00106 ! uracil relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UER00636 {cardinality="1", direction="RL", order="1"} ! UMP from uracil: step 1/1 relationship: part_of UPa:UER00636 ! UMP from uracil: step 1/1 [Term] id: UPa:UCR00974 name: H(2)O + cytosine = NH(3) + uracil namespace: reaction xref: KEGG:R00974 "KEGG reaction" xref: METACYC:CYTDEAM-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20608 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00380 ! cytosine relationship: has_input_compound UPa:UPC00380 {cardinality="1"} ! cytosine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: has_output_compound UPa:UPC00106 ! uracil relationship: part_of UPa:UER00635 ! uracil from cytosine: step 1/1 relationship: part_of UPa:UER00635 {cardinality="1", direction="LR", order="1"} ! uracil from cytosine: step 1/1 [Term] id: UPa:UCR00976 name: H(2)O + acceptor + uracil = barbiturate + reduced acceptor namespace: reaction xref: KEGG:R00976 "KEGG reaction" xref: METACYC:URACIL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22755 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00106 ! uracil relationship: has_input_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00813 {cardinality="1"} ! barbiturate relationship: has_output_compound UPa:UPC00813 ! barbiturate relationship: part_of UPa:UER00643 {cardinality="1", direction="LR", order="1"} ! malonate and urea from uracil: step 1/3 relationship: part_of UPa:UER00643 ! malonate and urea from uracil: step 1/3 [Term] id: UPa:UCR00985 name: NH(3) + chorismate = H(2)O + anthranilate + pyruvate namespace: reaction xref: KEGG:R00985 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00251 ! chorismate relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00108 ! anthranilate relationship: has_output_compound UPa:UPC00108 {cardinality="1"} ! anthranilate relationship: part_of UPa:UER00040 ! L-tryptophan from chorismate: step 1/5 relationship: part_of UPa:UER00040 {cardinality="1", direction="LR", order="1"} ! L-tryptophan from chorismate: step 1/5 [Term] id: UPa:UCR00987 name: H(2)O + L-kynurenine = L-alanine + anthranilate namespace: reaction xref: KEGG:R00987 "KEGG reaction" xref: METACYC:KYNURENINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16816 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00328 ! L-kynurenine relationship: has_input_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00041 ! L-alanine relationship: has_output_compound UPa:UPC00108 ! anthranilate relationship: has_output_compound UPa:UPC00108 {cardinality="1"} ! anthranilate relationship: part_of UPa:UER00455 ! L-alanine and anthranilate from L-kynurenine: step 1/1 relationship: part_of UPa:UER00455 {cardinality="1", direction="LR", order="1"} ! L-alanine and anthranilate from L-kynurenine: step 1/1 [Term] id: UPa:UCR00994 name: 2-oxobutanoate + CO(2) + H(+) + NADH = D-erythro-3-methylmalic acid + NAD(+) namespace: reaction xref: KEGG:R00994 "KEGG reaction" xref: RHEA:32718 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00109 ! 2-oxobutanoate relationship: has_input_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC06032 {cardinality="1"} ! D-erythro-3-methylmalic acid relationship: has_output_compound UPa:UPC06032 ! D-erythro-3-methylmalic acid relationship: part_of UPa:UER00069 ! 2-oxobutanoate from pyruvate: step 3/3 relationship: part_of UPa:UER00069 {cardinality="1", direction="RL", order="1"} ! 2-oxobutanoate from pyruvate: step 3/3 [Term] id: UPa:UCR00996 name: L-threonine = 2-oxobutanoate + NH(3) namespace: reaction xref: KEGG:R00996 "KEGG reaction" xref: METACYC:THREDEHYD-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22111 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: has_input_compound UPa:UPC00188 ! L-threonine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00109 ! 2-oxobutanoate relationship: part_of UPa:UER00054 ! 2-oxobutanoate from L-threonine: step 1/1 relationship: part_of UPa:UER00054 {cardinality="1", direction="LR", order="1"} ! 2-oxobutanoate from L-threonine: step 1/1 relationship: part_of UPa:UER00507 {cardinality="1", direction="LR", order="1"} ! propanoate from L-threonine: step 1/4 relationship: part_of UPa:UER00507 ! propanoate from L-threonine: step 1/4 [Term] id: UPa:UCR01001 name: H(2)O + L-cystathionine = 2-oxobutanoate + L-cysteine + NH(3) namespace: reaction xref: KEGG:R01001 "KEGG reaction" xref: METACYC:RXN-15130 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14008 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: has_input_compound UPa:UPC02291 ! L-cystathionine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00097 ! L-cysteine relationship: has_output_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_output_compound UPa:UPC00109 ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: part_of UPa:UER00202 {cardinality="1", direction="LR", order="1"} ! L-cysteine from L-homocysteine and L-serine: step 2/2 relationship: part_of UPa:UER00202 ! L-cysteine from L-homocysteine and L-serine: step 2/2 [Term] id: UPa:UCR01011 name: ATP + glycerone = ADP + glycerone phosphate namespace: reaction xref: KEGG:R01011 "KEGG reaction" xref: METACYC:GLYCERONE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15776 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00184 {cardinality="1"} ! glycerone relationship: has_input_compound UPa:UPC00184 ! glycerone relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: part_of UPa:UER00669 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from glycerol (oxidative route): step 2/2 relationship: part_of UPa:UER00669 ! glycerone phosphate from glycerol (oxidative route): step 2/2 [Term] id: UPa:UCR01015 name: D-glyceraldehyde 3-phosphate = glycerone phosphate namespace: reaction xref: KEGG:R01015 "KEGG reaction" xref: METACYC:TRIOSEPISOMERIZATION-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18588 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: part_of UPa:UER00189 {cardinality="1", direction="RL", order="1"} ! D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1 relationship: part_of UPa:UER00189 ! D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1 [Term] id: UPa:UCR01021 name: ATP + choline = ADP + phosphocholine namespace: reaction xref: KEGG:R01021 "KEGG reaction" xref: METACYC:CHOLINE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12840 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00588 ! phosphocholine relationship: has_output_compound UPa:UPC00588 {cardinality="1"} ! phosphocholine relationship: part_of UPa:UER00737 {cardinality="1", direction="LR", order="1"} ! phosphocholine from choline: step 1/1 relationship: part_of UPa:UER00737 ! phosphocholine from choline: step 1/1 [Term] id: UPa:UCR01022 name: O(2) + choline = H(2)O(2) + betaine aldehyde namespace: reaction xref: KEGG:R01022 "KEGG reaction" xref: METACYC:CHOLINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13508 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: part_of UPa:UER00384 {cardinality="1", direction="LR", order="1"} ! betaine from choline: step 1/1 relationship: part_of UPa:UER00384 ! betaine from choline: step 1/1 [Term] id: UPa:UCR01025 name: acceptor + choline = betaine aldehyde + reduced acceptor namespace: reaction xref: KEGG:R01025 "KEGG reaction" xref: METACYC:CHD-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17436 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: part_of UPa:UER00385 ! betaine aldehyde from choline (cytochrome c reductase route): step 1/1 relationship: part_of UPa:UER00385 {cardinality="1", direction="LR", order="1"} ! betaine aldehyde from choline (cytochrome c reductase route): step 1/1 [Term] id: UPa:UCR01028 name: H(2)O + choline sulfate = choline + sulfate namespace: reaction xref: KEGG:R01028 "KEGG reaction" xref: METACYC:CHOLINE-SULFATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20823 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00919 ! choline sulfate relationship: has_input_compound UPa:UPC00919 {cardinality="1"} ! choline sulfate relationship: has_output_compound UPa:UPC00059 ! sulfate relationship: has_output_compound UPa:UPC00059 {cardinality="1"} ! sulfate relationship: has_output_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_output_compound UPa:UPC00114 ! choline relationship: part_of UPa:UER00431 {cardinality="1", direction="LR", order="1"} ! choline from choline sulfate: step 1/1 relationship: part_of UPa:UER00431 ! choline from choline sulfate: step 1/1 [Term] id: UPa:UCR01034 name: NAD(+) + glycerol = H(+) + NADH + glycerone namespace: reaction xref: KEGG:R01034 "KEGG reaction" xref: METACYC:GLYCDEH-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13772 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00116 {cardinality="1"} ! glycerol relationship: has_input_compound UPa:UPC00116 ! glycerol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00184 {cardinality="1"} ! glycerone relationship: has_output_compound UPa:UPC00184 ! glycerone relationship: part_of UPa:UER00668 ! glycerone phosphate from glycerol (oxidative route): step 1/2 relationship: part_of UPa:UER00668 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from glycerol (oxidative route): step 1/2 [Term] id: UPa:UCR01047 name: glycerol = 3-hydroxypropanal + H(2)O namespace: reaction xref: KEGG:R01047 "KEGG reaction" xref: METACYC:GLYCEROL-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19768 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00116 {cardinality="1"} ! glycerol relationship: has_input_compound UPa:UPC00116 ! glycerol relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00969 ! 3-hydroxypropanal relationship: has_output_compound UPa:UPC00969 {cardinality="1"} ! 3-hydroxypropanal relationship: part_of UPa:UER00670 ! propane-1,3-diol from glycerol (reductive route): step 1/2 relationship: part_of UPa:UER00670 {cardinality="1", direction="LR", order="1"} ! propane-1,3-diol from glycerol (reductive route): step 1/2 [Term] id: UPa:UCR01049 name: ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP namespace: reaction xref: KEGG:R01049 "KEGG reaction" xref: METACYC:PRPPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15612 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: has_input_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UER00172 ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1 relationship: part_of UPa:UER00172 {cardinality="1", direction="LR", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1 [Term] id: UPa:UCR01051 name: ATP + D-ribose = ADP + D-ribose 5-phosphate namespace: reaction xref: KEGG:R01051 "KEGG reaction" xref: METACYC:RIBOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13700 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00121 ! D-ribose relationship: has_input_compound UPa:UPC00121 {cardinality="1"} ! D-ribose relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: part_of UPa:UER00889 {cardinality="1", direction="LR", order="1"} ! D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2 relationship: part_of UPa:UER00889 ! D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2 [Term] id: UPa:UCR01056 name: D-ribose 5-phosphate = D-ribulose 5-phosphate namespace: reaction xref: KEGG:R01056 "KEGG reaction" xref: METACYC:RIB5PISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14660 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: has_input_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: part_of UPa:UER00412 ! D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1 relationship: part_of UPa:UER00412 {cardinality="1", direction="RL", order="1"} ! D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1 [Term] id: UPa:UCR01057 name: alpha-D-ribose 1-phosphate = D-ribose 5-phosphate namespace: reaction xref: KEGG:R01057 "KEGG reaction" xref: METACYC:PPENTOMUT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18796 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00620 ! alpha-D-ribose 1-phosphate relationship: has_input_compound UPa:UPC00620 {cardinality="1"} ! alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: part_of UPa:UER00173 ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3 relationship: part_of UPa:UER00173 {cardinality="1", direction="RL", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3 [Term] id: UPa:UCR01061 name: D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = 3-phospho-D-glyceroyl phosphate + H(+) + NADH namespace: reaction xref: KEGG:R01061 "KEGG reaction" xref: METACYC:GAPOXNPHOSPHN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10303 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00236 {cardinality="1"} ! 3-phospho-D-glyceroyl phosphate relationship: has_output_compound UPa:UPC00236 ! 3-phospho-D-glyceroyl phosphate relationship: part_of UPa:UER00184 {cardinality="1", direction="LR", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 1/5 relationship: part_of UPa:UER00184 ! pyruvate from D-glyceraldehyde 3-phosphate: step 1/5 [Term] id: UPa:UCR01064 name: 6-phospho-2-dehydro-3-deoxy-D-galactonic acid = D-glyceraldehyde 3-phosphate + pyruvate namespace: reaction xref: KEGG:R01064 "KEGG reaction" xref: METACYC:DEHYDDEOXPHOSGALACT-ALDOL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24467 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01286 {cardinality="1"} ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid relationship: has_input_compound UPa:UPC01286 ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UER00520 ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 3/3 relationship: part_of UPa:UER00520 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 3/3 [Term] id: UPa:UCR01066 name: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde namespace: reaction xref: KEGG:R01066 "KEGG reaction" xref: METACYC:DEOXYRIBOSE-P-ALD-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12824 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00673 ! 2-deoxy-D-ribose 5-phosphate relationship: has_input_compound UPa:UPC00673 {cardinality="1"} ! 2-deoxy-D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UER00468 ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2 relationship: part_of UPa:UER00468 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2 [Term] id: UPa:UCR01068 name: D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate namespace: reaction xref: KEGG:R01068 "KEGG reaction" xref: METACYC:F16ALDOLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14732 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00354 ! D-fructose 1,6-bisphosphate relationship: has_input_compound UPa:UPC00354 {cardinality="1"} ! D-fructose 1,6-bisphosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UER00183 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4 relationship: part_of UPa:UER00183 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4 [Term] id: UPa:UCR01069 name: D-tagatose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate namespace: reaction xref: KEGG:R01069 "KEGG reaction" xref: METACYC:TAGAALDOL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22951 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03785 ! D-tagatose 1,6-bisphosphate relationship: has_input_compound UPa:UPC03785 {cardinality="1"} ! D-tagatose 1,6-bisphosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UER00716 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2 relationship: part_of UPa:UER00716 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2 [Term] id: UPa:UCR01071 name: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP namespace: reaction xref: KEGG:R01071 "KEGG reaction" xref: METACYC:ATPPHOSPHORIBOSYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18476 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC02739 ! 1-(5-phospho-D-ribosyl)-ATP relationship: has_input_compound UPa:UPC02739 {cardinality="1"} ! 1-(5-phospho-D-ribosyl)-ATP relationship: has_output_compound UPa:UPC00002 ! ATP relationship: has_output_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UER00006 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9 relationship: part_of UPa:UER00006 {cardinality="1", direction="RL", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9 [Term] id: UPa:UCR01072 name: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O + L-glutamine namespace: reaction xref: KEGG:R01072 "KEGG reaction" xref: METACYC:PRPPAMIDOTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14908 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC03090 ! 5-phospho-beta-D-ribosylamine relationship: has_input_compound UPa:UPC03090 {cardinality="1"} ! 5-phospho-beta-D-ribosylamine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00064 ! L-glutamine relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UER00124 ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2 relationship: part_of UPa:UER00124 {cardinality="1", direction="RL", order="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2 [Term] id: UPa:UCR01073 name: N-(5-phospho-beta-D-ribosyl)anthranilic acid + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate namespace: reaction xref: KEGG:R01073 "KEGG reaction" xref: METACYC:PRTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11771 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC04302 {cardinality="1"} ! N-(5-phospho-beta-D-ribosyl)anthranilic acid relationship: has_input_compound UPa:UPC04302 ! N-(5-phospho-beta-D-ribosyl)anthranilic acid relationship: has_output_compound UPa:UPC00108 {cardinality="1"} ! anthranilate relationship: has_output_compound UPa:UPC00108 ! anthranilate relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UER00041 {cardinality="1", direction="RL", order="1"} ! L-tryptophan from chorismate: step 2/5 relationship: part_of UPa:UER00041 ! L-tryptophan from chorismate: step 2/5 [Term] id: UPa:UCR01078 name: 2 H(+) + 2 S-adenosyl-L-methionine + dethiobiotin + 2 e- + sulfur donor = 2 5'-deoxyadenosine + 2 L-methionine + biotin namespace: reaction xref: KEGG:R01078 "KEGG reaction" xref: METACYC:2.8.1.6-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22063 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01909 ! dethiobiotin relationship: has_input_compound UPa:UPC01909 {cardinality="1"} ! dethiobiotin relationship: has_input_compound UPa:UPC05359 ! e- relationship: has_input_compound UPa:UPC05359 {cardinality="1"} ! e- relationship: has_input_compound UPa:UPC17023 {cardinality="1"} ! sulfur donor relationship: has_input_compound UPa:UPC17023 ! sulfur donor relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC00120 {cardinality="1"} ! biotin relationship: has_output_compound UPa:UPC00120 ! biotin relationship: has_output_compound UPa:UPC05198 ! 5'-deoxyadenosine relationship: has_output_compound UPa:UPC05198 {cardinality="1"} ! 5'-deoxyadenosine relationship: part_of UPa:UER00162 ! biotin from 7,8-diaminononanoate: step 2/2 relationship: part_of UPa:UER00162 {cardinality="1", direction="LR", order="1"} ! biotin from 7,8-diaminononanoate: step 2/2 [Term] id: UPa:UCR01080 name: H(2)O + uridine = D-ribose + uracil namespace: reaction xref: KEGG:R01080 "KEGG reaction" xref: METACYC:URIDINE-NUCLEOSIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15580 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00299 ! uridine relationship: has_input_compound UPa:UPC00299 {cardinality="1"} ! uridine relationship: has_output_compound UPa:UPC00106 ! uracil relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: has_output_compound UPa:UPC00121 ! D-ribose relationship: has_output_compound UPa:UPC00121 {cardinality="1"} ! D-ribose relationship: part_of UPa:UER00634 {cardinality="1", direction="LR", order="1"} ! uracil from uridine (hydrolase route): step 1/1 relationship: part_of UPa:UER00634 ! uracil from uridine (hydrolase route): step 1/1 [Term] id: UPa:UCR01082 name: (S)-malate = H(2)O + fumarate namespace: reaction xref: KEGG:R01082 "KEGG reaction" xref: METACYC:FUMHYDR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12463 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00149 ! (S)-malate relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: part_of UPa:UER01007 {cardinality="1", direction="RL", order="1"} ! (S)-malate from fumarate: step 1/1 relationship: part_of UPa:UER01007 ! (S)-malate from fumarate: step 1/1 [Term] id: UPa:UCR01083 name: N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate namespace: reaction xref: KEGG:R01083 "KEGG reaction" xref: METACYC:AMPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16856 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03794 ! N(6)-(1,2-dicarboxyethyl)-AMP relationship: has_input_compound UPa:UPC03794 {cardinality="1"} ! N(6)-(1,2-dicarboxyethyl)-AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: part_of UPa:UER00336 ! AMP from IMP: step 2/2 relationship: part_of UPa:UER00336 {cardinality="1", direction="LR", order="1"} ! AMP from IMP: step 2/2 [Term] id: UPa:UCR01086 name: (N(omega)-L-arginino)succinate = L-arginine + fumarate namespace: reaction xref: KEGG:R01086 "KEGG reaction" xref: METACYC:ARGSUCCINLYA-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24023 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03406 {cardinality="1"} ! (N(omega)-L-arginino)succinate relationship: has_input_compound UPa:UPC03406 ! (N(omega)-L-arginino)succinate relationship: has_output_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_output_compound UPa:UPC00062 ! L-arginine relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: part_of UPa:UER00114 {cardinality="1", direction="LR", order="1"} ! L-arginine from L-ornithine and carbamoyl phosphate: step 3/3 relationship: part_of UPa:UER00114 ! L-arginine from L-ornithine and carbamoyl phosphate: step 3/3 relationship: part_of UPa:UER00273 ! L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1 relationship: part_of UPa:UER00273 {cardinality="1", direction="LR", order="1"} ! L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1 [Term] id: UPa:UCR01088 name: H(2)O + L-leucine + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH + NH(3) namespace: reaction xref: KEGG:R01088 "KEGG reaction" xref: METACYC:LEUCINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12223 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00123 {cardinality="1"} ! L-leucine relationship: has_input_compound UPa:UPC00123 ! L-leucine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate relationship: part_of UPa:UER00858 ! 4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route): step 1/1 relationship: part_of UPa:UER00858 {cardinality="1", direction="LR", order="1"} ! 4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route): step 1/1 [Term] id: UPa:UCR01090 name: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate namespace: reaction xref: KEGG:R01090 "KEGG reaction" xref: METACYC:BRANCHED-CHAINAMINOTRANSFERLEU-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18324 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00123 ! L-leucine relationship: has_input_compound UPa:UPC00123 {cardinality="1"} ! L-leucine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate relationship: part_of UPa:UER00073 ! L-leucine from 3-methyl-2-oxobutanoate: step 4/4 relationship: part_of UPa:UER00073 {cardinality="1", direction="RL", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate: step 4/4 relationship: part_of UPa:UER00857 {cardinality="1", direction="LR", order="1"} ! 4-methyl-2-oxopentanoate from L-leucine (aminotransferase route): step 1/1 relationship: part_of UPa:UER00857 ! 4-methyl-2-oxopentanoate from L-leucine (aminotransferase route): step 1/1 [Term] id: UPa:UCR01121 name: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + isopentenyl diphosphate + phosphate namespace: reaction xref: KEGG:R01121 "KEGG reaction" xref: METACYC:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23735 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01143 ! (R)-5-diphosphomevalonate relationship: has_input_compound UPa:UPC01143 {cardinality="1"} ! (R)-5-diphosphomevalonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_output_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: part_of UPa:UER00100 ! isopentenyl diphosphate from (R)-mevalonate: step 3/3 relationship: part_of UPa:UER00100 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from (R)-mevalonate: step 3/3 [Term] id: UPa:UCR01123 name: isopentenyl diphosphate = dimethylallyl diphosphate namespace: reaction xref: KEGG:R01123 "KEGG reaction" xref: METACYC:IPPISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23287 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_output_compound UPa:UPC00235 {cardinality="1"} ! dimethylallyl diphosphate relationship: has_output_compound UPa:UPC00235 ! dimethylallyl diphosphate relationship: part_of UPa:UER00104 ! dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1 relationship: part_of UPa:UER00104 {cardinality="1", direction="LR", order="1"} ! dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1 [Term] id: UPa:UCR01127 name: H(2)O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide namespace: reaction xref: KEGG:R01127 "KEGG reaction" xref: METACYC:IMPCYCLOHYDROLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18448 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00130 ! IMP relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: has_output_compound UPa:UPC04734 {cardinality="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04734 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UER00135 {cardinality="1", direction="RL", order="1"} ! IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1 relationship: part_of UPa:UER00135 ! IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1 [Term] id: UPa:UCR01130 name: H(2)O + IMP + NAD(+) = H(+) + NADH + XMP namespace: reaction xref: KEGG:R01130 "KEGG reaction" xref: METACYC:IMP-DEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11711 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: has_input_compound UPa:UPC00130 ! IMP relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00655 ! XMP relationship: has_output_compound UPa:UPC00655 {cardinality="1"} ! XMP relationship: part_of UPa:UER00295 ! XMP from IMP: step 1/1 relationship: part_of UPa:UER00295 {cardinality="1", direction="LR", order="1"} ! XMP from IMP: step 1/1 [Term] id: UPa:UCR01131 name: ATP + inosine = ADP + IMP namespace: reaction xref: KEGG:R01131 "KEGG reaction" xref: METACYC:INOSINEKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21143 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00294 ! inosine relationship: has_input_compound UPa:UPC00294 {cardinality="1"} ! inosine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: has_output_compound UPa:UPC00130 ! IMP relationship: part_of UPa:UER00647 ! IMP from inosine: step 1/1 relationship: part_of UPa:UER00647 {cardinality="1", direction="LR", order="1"} ! IMP from inosine: step 1/1 [Term] id: UPa:UCR01132 name: IMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine namespace: reaction xref: KEGG:R01132 "KEGG reaction" xref: METACYC:HYPOXANPRIBOSYLTRAN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17976 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: has_input_compound UPa:UPC00130 ! IMP relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00262 {cardinality="1"} ! hypoxanthine relationship: has_output_compound UPa:UPC00262 ! hypoxanthine relationship: part_of UPa:UER00648 {cardinality="1", direction="RL", order="1"} ! IMP from hypoxanthine: step 1/1 relationship: part_of UPa:UER00648 ! IMP from hypoxanthine: step 1/1 [Term] id: UPa:UCR01135 name: GTP + IMP + L-aspartate = GDP + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate namespace: reaction xref: KEGG:R01135 "KEGG reaction" xref: METACYC:ADENYLOSUCCINATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15756 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: has_input_compound UPa:UPC00130 ! IMP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00035 ! GDP relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_output_compound UPa:UPC03794 ! N(6)-(1,2-dicarboxyethyl)-AMP relationship: has_output_compound UPa:UPC03794 {cardinality="1"} ! N(6)-(1,2-dicarboxyethyl)-AMP relationship: part_of UPa:UER00335 {cardinality="1", direction="LR", order="1"} ! AMP from IMP: step 1/2 relationship: part_of UPa:UER00335 ! AMP from IMP: step 1/2 [Term] id: UPa:UCR01151 name: H(2)O + O(2) + putrescine = 4-aminobutanal + H(2)O(2) + NH(3) namespace: reaction xref: KEGG:R01151 "KEGG reaction" xref: METACYC:PUTRESCINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18276 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal relationship: has_output_compound UPa:UPC00555 ! 4-aminobutanal relationship: part_of UPa:UER00289 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanal from putrescine (amine oxidase route): step 1/1 relationship: part_of UPa:UER00289 ! 4-aminobutanal from putrescine (amine oxidase route): step 1/1 [Term] id: UPa:UCR01152 name: H(2)O + N-carbamoylputrescine = CO(2) + NH(3) + putrescine namespace: reaction xref: KEGG:R01152 "KEGG reaction" xref: METACYC:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22287 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00436 {cardinality="1"} ! N-carbamoylputrescine relationship: has_input_compound UPa:UPC00436 ! N-carbamoylputrescine relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_output_compound UPa:UPC00134 ! putrescine relationship: part_of UPa:UER00286 {cardinality="1", direction="LR", order="1"} ! putrescine from N-carbamoylputrescine (amidase route): step 1/1 relationship: part_of UPa:UER00286 ! putrescine from N-carbamoylputrescine (amidase route): step 1/1 [Term] id: UPa:UCR01154 name: acetyl-CoA + putrescine = CoA + N-acetylputrescine namespace: reaction xref: KEGG:R01154 "KEGG reaction" xref: METACYC:RXN-0 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25184 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC02714 {cardinality="1"} ! N-acetylputrescine relationship: has_output_compound UPa:UPC02714 ! N-acetylputrescine relationship: part_of UPa:UER00363 ! N-acetylputrescine from putrescine: step 1/1 relationship: part_of UPa:UER00363 {cardinality="1", direction="LR", order="1"} ! N-acetylputrescine from putrescine: step 1/1 [Term] id: UPa:UCR01155 name: 2-oxoglutarate + putrescine = 4-aminobutanal + L-glutamate namespace: reaction xref: KEGG:R01155 "KEGG reaction" xref: METACYC:PUTTRANSAM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23819 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal relationship: has_output_compound UPa:UPC00555 ! 4-aminobutanal relationship: part_of UPa:UER00290 ! 4-aminobutanal from putrescine (transaminase route): step 1/1 relationship: part_of UPa:UER00290 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanal from putrescine (transaminase route): step 1/1 [Term] id: UPa:UCR01157 name: H(2)O + agmatine = putrescine + urea namespace: reaction xref: KEGG:R01157 "KEGG reaction" xref: METACYC:AGMATIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13932 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00179 {cardinality="1"} ! agmatine relationship: has_input_compound UPa:UPC00179 ! agmatine relationship: has_output_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_output_compound UPa:UPC00134 ! putrescine relationship: part_of UPa:UER00287 ! putrescine from agmatine: step 1/1 relationship: part_of UPa:UER00287 {cardinality="1", direction="LR", order="1"} ! putrescine from agmatine: step 1/1 [Term] id: UPa:UCR01158 name: H(2)O + L-histidinol + 2 NAD(+) = 2 H(+) + L-histidine + 2 NADH namespace: reaction xref: KEGG:R01158 "KEGG reaction" xref: METACYC:RXN-8001 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20644 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00860 ! L-histidinol relationship: has_input_compound UPa:UPC00860 {cardinality="1"} ! L-histidinol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00135 {cardinality="1"} ! L-histidine relationship: has_output_compound UPa:UPC00135 ! L-histidine relationship: part_of UPa:UER00014 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9 relationship: part_of UPa:UER00014 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9 [Term] id: UPa:UCR01167 name: L-histidine = CO(2) + histamine namespace: reaction xref: KEGG:R01167 "KEGG reaction" xref: METACYC:HISTIDINE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20843 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00135 {cardinality="1"} ! L-histidine relationship: has_input_compound UPa:UPC00135 ! L-histidine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00388 ! histamine relationship: has_output_compound UPa:UPC00388 {cardinality="1"} ! histamine relationship: part_of UPa:UER00786 ! histamine from L-histidine: step 1/1 relationship: part_of UPa:UER00786 {cardinality="1", direction="LR", order="1"} ! histamine from L-histidine: step 1/1 [Term] id: UPa:UCR01168 name: L-histidine = NH(3) + trans-urocanate namespace: reaction xref: KEGG:R01168 "KEGG reaction" xref: METACYC:HISTIDINE-AMMONIA-LYASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21235 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00135 ! L-histidine relationship: has_input_compound UPa:UPC00135 {cardinality="1"} ! L-histidine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00785 ! trans-urocanate relationship: has_output_compound UPa:UPC00785 {cardinality="1"} ! trans-urocanate relationship: part_of UPa:UER00549 ! N-formimidoyl-L-glutamate from L-histidine: step 1/3 relationship: part_of UPa:UER00549 {cardinality="1", direction="LR", order="1"} ! N-formimidoyl-L-glutamate from L-histidine: step 1/3 [Term] id: UPa:UCR01183 name: NAD(+) + myo-inositol = H(+) + NADH + scyllo-inosose namespace: reaction xref: KEGG:R01183 "KEGG reaction" xref: METACYC:MYO-INOSITOL-2-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16952 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00137 ! myo-inositol relationship: has_input_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00691 {cardinality="1"} ! scyllo-inosose relationship: has_output_compound UPa:UPC00691 ! scyllo-inosose relationship: part_of UPa:UER00143 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 1/7 relationship: part_of UPa:UER00143 ! acetyl-CoA from myo-inositol: step 1/7 [Term] id: UPa:UCR01184 name: O(2) + myo-inositol = D-glucuronate + H(2)O namespace: reaction xref: KEGG:R01184 "KEGG reaction" xref: METACYC:MYO-INOSITOL-OXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23699 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00137 ! myo-inositol relationship: has_input_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00191 ! D-glucuronate relationship: has_output_compound UPa:UPC00191 {cardinality="1"} ! D-glucuronate relationship: part_of UPa:UER00527 ! D-glucuronate from myo-inositol: step 1/1 relationship: part_of UPa:UER00527 {cardinality="1", direction="LR", order="1"} ! D-glucuronate from myo-inositol: step 1/1 [Term] id: UPa:UCR01187 name: 1D-myo-inositol 3-phosphate + H(2)O = myo-inositol + phosphate namespace: reaction xref: KEGG:R01187 "KEGG reaction" xref: METACYC:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:30742 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04006 ! 1D-myo-inositol 3-phosphate relationship: has_input_compound UPa:UPC04006 {cardinality="1"} ! 1D-myo-inositol 3-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00137 ! myo-inositol relationship: has_output_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol relationship: part_of UPa:UER00788 ! myo-inositol from D-glucose 6-phosphate: step 2/2 relationship: part_of UPa:UER00788 {cardinality="1", direction="LR", order="1"} ! myo-inositol from D-glucose 6-phosphate: step 2/2 [Term] id: UPa:UCR01197 name: CO(2) + 2 H(+) + 2 reduced ferredoxin + succinyl-CoA = 2-oxoglutarate + CoA + 2 oxidized ferredoxin namespace: reaction xref: KEGG:R01197 "KEGG reaction" xref: METACYC:2-OXOGLUTARATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17300 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00138 ! reduced ferredoxin relationship: has_input_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00139 ! oxidized ferredoxin relationship: part_of UPa:UER00998 {cardinality="1", direction="RL", order="1"} ! succinyl-CoA from 2-oxoglutarate (synthase route): step 1/1 relationship: part_of UPa:UER00998 ! succinyl-CoA from 2-oxoglutarate (synthase route): step 1/1 [Term] id: UPa:UCR01213 name: (2S)-2-isopropylmalate + CoA = 3-methyl-2-oxobutanoate + H(2)O + acetyl-CoA namespace: reaction xref: KEGG:R01213 "KEGG reaction" xref: METACYC:2-ISOPROPYLMALATESYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21527 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC02504 ! (2S)-2-isopropylmalate relationship: has_input_compound UPa:UPC02504 {cardinality="1"} ! (2S)-2-isopropylmalate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate relationship: has_output_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate relationship: part_of UPa:UER00070 {cardinality="1", direction="RL", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate: step 1/4 relationship: part_of UPa:UER00070 ! L-leucine from 3-methyl-2-oxobutanoate: step 1/4 [Term] id: UPa:UCR01214 name: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate namespace: reaction xref: KEGG:R01214 "KEGG reaction" xref: METACYC:BRANCHED-CHAINAMINOTRANSFERVAL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24816 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00183 {cardinality="1"} ! L-valine relationship: has_input_compound UPa:UPC00183 ! L-valine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate relationship: has_output_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate relationship: part_of UPa:UER00062 {cardinality="1", direction="RL", order="1"} ! L-valine from pyruvate: step 4/4 relationship: part_of UPa:UER00062 ! L-valine from pyruvate: step 4/4 [Term] id: UPa:UCR01226 name: 3-methyl-2-oxobutanoate + 5,10-methylene-THF + H(2)O = 2-dehydropantoate + 5,6,7,8-tetrahydrofolate namespace: reaction xref: KEGG:R01226 "KEGG reaction" xref: METACYC:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11827 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate relationship: has_input_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate relationship: has_input_compound UPa:UPC00143 ! 5,10-methylene-THF relationship: has_input_compound UPa:UPC00143 {cardinality="1"} ! 5,10-methylene-THF relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00966 ! 2-dehydropantoate relationship: has_output_compound UPa:UPC00966 {cardinality="1"} ! 2-dehydropantoate relationship: part_of UPa:UER00003 {cardinality="1", direction="LR", order="1"} ! (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2 relationship: part_of UPa:UER00003 ! (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2 [Term] id: UPa:UCR01229 name: GMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + guanine namespace: reaction xref: KEGG:R01229 "KEGG reaction" xref: METACYC:GUANPRIBOSYLTRAN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25427 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: has_input_compound UPa:UPC00144 ! GMP relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00242 ! guanine relationship: has_output_compound UPa:UPC00242 {cardinality="1"} ! guanine relationship: part_of UPa:UER00887 ! GMP from guanine: step 1/1 relationship: part_of UPa:UER00887 {cardinality="1", direction="RL", order="1"} ! GMP from guanine: step 1/1 [Term] id: UPa:UCR01230 name: ATP + NH(3) + XMP = AMP + GMP + diphosphate namespace: reaction xref: KEGG:R01230 "KEGG reaction" xref: METACYC:GMP-SYN-NH3-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18304 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00655 {cardinality="1"} ! XMP relationship: has_input_compound UPa:UPC00655 ! XMP relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00144 ! GMP relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: part_of UPa:UER00297 ! GMP from XMP (ammonia route): step 1/1 relationship: part_of UPa:UER00297 {cardinality="1", direction="LR", order="1"} ! GMP from XMP (ammonia route): step 1/1 [Term] id: UPa:UCR01231 name: ATP + H(2)O + L-glutamine + XMP = AMP + GMP + L-glutamate + diphosphate namespace: reaction xref: KEGG:R01231 "KEGG reaction" xref: METACYC:GMP-SYN-GLUT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11683 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00655 {cardinality="1"} ! XMP relationship: has_input_compound UPa:UPC00655 ! XMP relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00144 ! GMP relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: part_of UPa:UER00296 ! GMP from XMP (L-Gln route): step 1/1 relationship: part_of UPa:UER00296 {cardinality="1", direction="LR", order="1"} ! GMP from XMP (L-Gln route): step 1/1 [Term] id: UPa:UCR01234 name: 3',5'-cyclic GMP + H(2)O = GMP namespace: reaction xref: KEGG:R01234 "KEGG reaction" xref: METACYC:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16960 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00942 {cardinality="1"} ! 3',5'-cyclic GMP relationship: has_input_compound UPa:UPC00942 ! 3',5'-cyclic GMP relationship: has_output_compound UPa:UPC00144 ! GMP relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: part_of UPa:UER00748 ! GMP from 3',5'-cyclic GMP: step 1/1 relationship: part_of UPa:UER00748 {cardinality="1", direction="LR", order="1"} ! GMP from 3',5'-cyclic GMP: step 1/1 [Term] id: UPa:UCR01248 name: L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylic acid + H(+) + NADH namespace: reaction xref: KEGG:R01248 "KEGG reaction" xref: RHEA:14108 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00148 ! L-proline relationship: has_input_compound UPa:UPC00148 {cardinality="1"} ! L-proline relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03912 {cardinality="1"} ! (S)-1-pyrroline-5-carboxylic acid relationship: has_output_compound UPa:UPC03912 ! (S)-1-pyrroline-5-carboxylic acid relationship: part_of UPa:UER00361 {cardinality="1", direction="RL", order="2"} ! L-proline from L-glutamate 5-semialdehyde: step 1/1 relationship: part_of UPa:UER00361 ! L-proline from L-glutamate 5-semialdehyde: step 1/1 [Term] id: UPa:UCR01253 name: L-proline + Quinone = (S)-1-pyrroline-5-carboxylic acid + Hydroquinone namespace: reaction xref: KEGG:R01253 "KEGG reaction" xref: METACYC:RXN-14903 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23787 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00148 {cardinality="1"} ! L-proline relationship: has_input_compound UPa:UPC00148 ! L-proline relationship: has_input_compound UPa:UPC15602 ! Quinone relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone relationship: has_output_compound UPa:UPC03912 {cardinality="1"} ! (S)-1-pyrroline-5-carboxylic acid relationship: has_output_compound UPa:UPC03912 ! (S)-1-pyrroline-5-carboxylic acid relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone relationship: has_output_compound UPa:UPC15603 ! Hydroquinone relationship: part_of UPa:UER00373 ! L-glutamate from L-proline: step 1/2 relationship: part_of UPa:UER00373 {cardinality="1", direction="LR", order="1"} ! L-glutamate from L-proline: step 1/2 [Term] id: UPa:UCR01268 name: H(2)O + nicotinamide = NH(3) + nicotinate namespace: reaction xref: KEGG:R01268 "KEGG reaction" xref: METACYC:NICOTINAMID-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14548 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00153 ! nicotinamide relationship: has_input_compound UPa:UPC00153 {cardinality="1"} ! nicotinamide relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00253 {cardinality="1"} ! nicotinate relationship: has_output_compound UPa:UPC00253 ! nicotinate relationship: part_of UPa:UER00790 ! nicotinate from nicotinamide: step 1/1 relationship: part_of UPa:UER00790 {cardinality="1", direction="LR", order="1"} ! nicotinate from nicotinamide: step 1/1 [Term] id: UPa:UCR01271 name: diphosphate + nicotinamide D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide namespace: reaction xref: KEGG:R01271 "KEGG reaction" xref: METACYC:2.4.2.12-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16152 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC00455 ! nicotinamide D-ribonucleotide relationship: has_input_compound UPa:UPC00455 {cardinality="1"} ! nicotinamide D-ribonucleotide relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00153 {cardinality="1"} ! nicotinamide relationship: has_output_compound UPa:UPC00153 ! nicotinamide relationship: part_of UPa:UER00890 ! nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1 relationship: part_of UPa:UER00890 {cardinality="1", direction="RL", order="1"} ! nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1 [Term] id: UPa:UCR01286 name: H(2)O + L-cystathionine = L-homocysteine + NH(3) + pyruvate namespace: reaction xref: KEGG:R01286 "KEGG reaction" xref: METACYC:CYSTATHIONINE-BETA-LYASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13968 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC02291 ! L-cystathionine relationship: has_input_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00155 ! L-homocysteine relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: part_of UPa:UER00078 ! L-homocysteine from L-cystathionine: step 1/1 relationship: part_of UPa:UER00078 {cardinality="1", direction="LR", order="1"} ! L-homocysteine from L-cystathionine: step 1/1 [Term] id: UPa:UCR01287 name: O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate namespace: reaction xref: KEGG:R01287 "KEGG reaction" xref: METACYC:ACETYLHOMOSER-CYS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:27825 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_input_compound UPa:UPC01077 ! O-acetyl-L-homoserine relationship: has_input_compound UPa:UPC01077 {cardinality="1"} ! O-acetyl-L-homoserine relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00155 ! L-homocysteine relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: part_of UPa:UER00079 {cardinality="1", direction="LR", order="1"} ! L-homocysteine from O-acetyl-L-homoserine: step 1/1 relationship: part_of UPa:UER00079 ! L-homocysteine from O-acetyl-L-homoserine: step 1/1 [Term] id: UPa:UCR01288 name: O-succinyl-L-homoserine + hydrogen sulfide = L-homocysteine + succinate namespace: reaction xref: KEGG:R01288 "KEGG reaction" xref: METACYC:RXN-9384 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:27829 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_input_compound UPa:UPC01118 ! O-succinyl-L-homoserine relationship: has_input_compound UPa:UPC01118 {cardinality="1"} ! O-succinyl-L-homoserine relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00155 ! L-homocysteine relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: part_of UPa:UER00449 {cardinality="1", direction="LR", order="1"} ! L-homocysteine from O-succinyl-L-homoserine: step 1/1 relationship: part_of UPa:UER00449 ! L-homocysteine from O-succinyl-L-homoserine: step 1/1 [Term] id: UPa:UCR01290 name: L-homocysteine + L-serine = H(2)O + L-cystathionine namespace: reaction xref: KEGG:R01290 "KEGG reaction" xref: METACYC:CYSTATHIONINE-BETA-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10115 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: has_output_compound UPa:UPC02291 ! L-cystathionine relationship: part_of UPa:UER00201 {cardinality="1", direction="LR", order="1"} ! L-cysteine from L-homocysteine and L-serine: step 1/2 relationship: part_of UPa:UER00201 ! L-cysteine from L-homocysteine and L-serine: step 1/2 [Term] id: UPa:UCR01295 name: H(+) + NADPH + O(2) + benzoate = 4-hydroxybenzoate + H(2)O + NADP(+) namespace: reaction xref: KEGG:R01295 "KEGG reaction" xref: METACYC:BENZOATE-4-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18036 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: has_input_compound UPa:UPC00180 ! benzoate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00156 {cardinality="1"} ! 4-hydroxybenzoate relationship: has_output_compound UPa:UPC00156 ! 4-hydroxybenzoate relationship: part_of UPa:UER00256 ! 3,4-dihydroxybenzoate from benzoate: step 1/2 relationship: part_of UPa:UER00256 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from benzoate: step 1/2 [Term] id: UPa:UCR01298 name: 4-hydroxybenzoate + H(+) + NADPH + O(2) = 3,4-dihydroxybenzoate + H(2)O + NADP(+) namespace: reaction xref: KEGG:R01298 "KEGG reaction" xref: METACYC:1.14.13.33-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: METACYC:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19480 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00156 {cardinality="1"} ! 4-hydroxybenzoate relationship: has_input_compound UPa:UPC00156 ! 4-hydroxybenzoate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: part_of UPa:UER00257 ! 3,4-dihydroxybenzoate from benzoate: step 2/2 relationship: part_of UPa:UER00257 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from benzoate: step 2/2 [Term] id: UPa:UCR01301 name: 4-hydroxybenzoyl-CoA + H(2)O = 4-hydroxybenzoate + CoA namespace: reaction xref: KEGG:R01301 "KEGG reaction" xref: METACYC:3.1.2.23-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11951 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02949 ! 4-hydroxybenzoyl-CoA relationship: has_input_compound UPa:UPC02949 {cardinality="1"} ! 4-hydroxybenzoyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00156 {cardinality="1"} ! 4-hydroxybenzoate relationship: has_output_compound UPa:UPC00156 ! 4-hydroxybenzoate relationship: part_of UPa:UER01022 {cardinality="1", direction="LR", order="1"} ! 4-hydroxybenzoate from 4-chlorobenzoate: step 3/3 relationship: part_of UPa:UER01022 ! 4-hydroxybenzoate from 4-chlorobenzoate: step 3/3 [Term] id: UPa:UCR01321 name: 1,2-diacyl-sn-glycerol + CDP-choline = CMP + phosphatidylcholine namespace: reaction xref: KEGG:R01321 "KEGG reaction" xref: METACYC:RXN-5781 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10311 "Rhea reaction" xref: RHEA:32942 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00307 ! CDP-choline relationship: has_input_compound UPa:UPC00307 {cardinality="1"} ! CDP-choline relationship: has_input_compound UPa:UPC00641 {cardinality="1"} ! 1,2-diacyl-sn-glycerol relationship: has_input_compound UPa:UPC00641 ! 1,2-diacyl-sn-glycerol relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00157 {cardinality="1"} ! phosphatidylcholine relationship: has_output_compound UPa:UPC00157 ! phosphatidylcholine relationship: part_of UPa:UER00740 {cardinality="1", direction="LR", order="1"} ! phosphatidylcholine from phosphocholine: step 2/2 relationship: part_of UPa:UER00740 ! phosphatidylcholine from phosphocholine: step 2/2 [Term] id: UPa:UCR01325 name: citrate = H(2)O + cis-aconitate namespace: reaction xref: KEGG:R01325 "KEGG reaction" xref: METACYC:ACONITATEDEHYDR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10231 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00158 ! citrate relationship: has_input_compound UPa:UPC00158 {cardinality="1"} ! citrate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00417 ! cis-aconitate relationship: has_output_compound UPa:UPC00417 {cardinality="1"} ! cis-aconitate relationship: part_of UPa:UER00718 ! isocitrate from oxaloacetate: step 2/2 relationship: part_of UPa:UER00718 {cardinality="1", direction="LR", order="1"} ! isocitrate from oxaloacetate: step 2/2 [Term] id: UPa:UCR01334 name: 2-phosphoglycolate + H(2)O = glycolate + phosphate namespace: reaction xref: KEGG:R01334 "KEGG reaction" xref: METACYC:GPH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14372 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00988 {cardinality="1"} ! 2-phosphoglycolate relationship: has_input_compound UPa:UPC00988 ! 2-phosphoglycolate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00160 ! glycolate relationship: has_output_compound UPa:UPC00160 {cardinality="1"} ! glycolate relationship: part_of UPa:UER00834 ! glycolate from 2-phosphoglycolate: step 1/1 relationship: part_of UPa:UER00834 {cardinality="1", direction="LR", order="1"} ! glycolate from 2-phosphoglycolate: step 1/1 relationship: part_of UPa:UER00911 {cardinality="1", direction="LR", order="1"} ! glycine from 2-phosphoglycolate: step 1/3 relationship: part_of UPa:UER00911 ! glycine from 2-phosphoglycolate: step 1/3 [Term] id: UPa:UCR01353 name: ATP + propanoate = ADP + propanoyl phosphate namespace: reaction xref: KEGG:R01353 "KEGG reaction" xref: METACYC:PROPKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23151 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00163 ! propanoate relationship: has_input_compound UPa:UPC00163 {cardinality="1"} ! propanoate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC02876 {cardinality="1"} ! propanoyl phosphate relationship: has_output_compound UPa:UPC02876 ! propanoyl phosphate relationship: part_of UPa:UER00510 {cardinality="1", direction="RL", order="1"} ! propanoate from L-threonine: step 4/4 relationship: part_of UPa:UER00510 ! propanoate from L-threonine: step 4/4 [Term] id: UPa:UCR01355 name: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate namespace: reaction xref: KEGG:R01355 "KEGG reaction" xref: METACYC:23-DIMETHYLMALATE-LYASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10475 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03652 ! (2R,3S)-2,3-dimethylmalate relationship: has_input_compound UPa:UPC03652 {cardinality="1"} ! (2R,3S)-2,3-dimethylmalate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00163 ! propanoate relationship: has_output_compound UPa:UPC00163 {cardinality="1"} ! propanoate relationship: part_of UPa:UER01019 ! propanoate and pyruvate from 6-hydroxynicotinate: step 8/8 relationship: part_of UPa:UER01019 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 8/8 [Term] id: UPa:UCR01360 name: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA namespace: reaction xref: KEGG:R01360 "KEGG reaction" xref: METACYC:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24407 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_input_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00164 ! acetoacetate relationship: has_output_compound UPa:UPC00164 {cardinality="1"} ! acetoacetate relationship: part_of UPa:UER00863 ! acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1 relationship: part_of UPa:UER00863 {cardinality="1", direction="LR", order="1"} ! acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1 [Term] id: UPa:UCR01364 name: acetoacetate + fumarate = 4-fumarylacetoacetate + H(2)O namespace: reaction xref: KEGG:R01364 "KEGG reaction" xref: METACYC:FUMARYLACETOACETASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10247 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00122 ! fumarate relationship: has_input_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: has_input_compound UPa:UPC00164 ! acetoacetate relationship: has_input_compound UPa:UPC00164 {cardinality="1"} ! acetoacetate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01061 ! 4-fumarylacetoacetate relationship: has_output_compound UPa:UPC01061 {cardinality="1"} ! 4-fumarylacetoacetate relationship: part_of UPa:UER00341 ! acetoacetate and fumarate from L-phenylalanine: step 6/6 relationship: part_of UPa:UER00341 {cardinality="1", direction="RL", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 6/6 [Term] id: UPa:UCR01373 name: prephenate = CO(2) + H(2)O + phenylpyruvate namespace: reaction xref: KEGG:R01373 "KEGG reaction" xref: METACYC:PREPHENATEDEHYDRAT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21651 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00166 ! phenylpyruvate relationship: has_output_compound UPa:UPC00166 {cardinality="1"} ! phenylpyruvate relationship: part_of UPa:UER00345 {cardinality="1", direction="LR", order="1"} ! phenylpyruvate from prephenate: step 1/1 relationship: part_of UPa:UER00345 ! phenylpyruvate from prephenate: step 1/1 [Term] id: UPa:UCR01384 name: UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose namespace: reaction xref: KEGG:R01384 "KEGG reaction" xref: METACYC:UDP-GLUCURONATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23919 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate relationship: has_input_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00190 ! UDP-alpha-D-xylose relationship: has_output_compound UPa:UPC00190 {cardinality="1"} ! UDP-alpha-D-xylose relationship: part_of UPa:UER00771 ! UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1 relationship: part_of UPa:UER00771 {cardinality="1", direction="LR", order="1"} ! UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1 [Term] id: UPa:UCR01388 name: D-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH namespace: reaction xref: KEGG:R01388 "KEGG reaction" xref: METACYC:GLYCERATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17908 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00168 ! 3-hydroxypyruvate relationship: has_output_compound UPa:UPC00168 {cardinality="1"} ! 3-hydroxypyruvate relationship: part_of UPa:UER00916 {cardinality="1", direction="RL", order="1"} ! 3-phospho-D-glycerate from glycine: step 3/4 relationship: part_of UPa:UER00916 ! 3-phospho-D-glycerate from glycine: step 3/4 relationship: part_of UPa:UER00983 ! None relationship: part_of UPa:UER00983 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01392 name: D-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH namespace: reaction xref: KEGG:R01392 "KEGG reaction" xref: METACYC:RXN0-300 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:18660 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00168 {cardinality="1"} ! 3-hydroxypyruvate relationship: has_output_compound UPa:UPC00168 ! 3-hydroxypyruvate relationship: part_of UPa:UER00984 ! None relationship: part_of UPa:UER00984 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01397 name: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + phosphate namespace: reaction xref: KEGG:R01397 "KEGG reaction" xref: METACYC:ASPCARBTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20016 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00438 ! N-carbamoyl-L-aspartate relationship: has_output_compound UPa:UPC00438 {cardinality="1"} ! N-carbamoyl-L-aspartate relationship: part_of UPa:UER00116 {cardinality="1", direction="LR", order="1"} ! (S)-dihydroorotate from bicarbonate: step 2/3 relationship: part_of UPa:UER00116 ! (S)-dihydroorotate from bicarbonate: step 2/3 [Term] id: UPa:UCR01398 name: L-ornithine + carbamoyl phosphate = L-citrulline + phosphate namespace: reaction xref: KEGG:R01398 "KEGG reaction" xref: METACYC:ORNCARBAMTRANSFER-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19516 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_input_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00327 {cardinality="1"} ! L-citrulline relationship: has_output_compound UPa:UPC00327 ! L-citrulline relationship: part_of UPa:UER00112 ! L-arginine from L-ornithine and carbamoyl phosphate: step 1/3 relationship: part_of UPa:UER00112 {cardinality="1", direction="LR", order="1"} ! L-arginine from L-ornithine and carbamoyl phosphate: step 1/3 relationship: part_of UPa:UER00271 ! L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1 relationship: part_of UPa:UER00271 {cardinality="1", direction="LR", order="1"} ! L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1 relationship: part_of UPa:UER00365 ! carbamoyl phosphate from L-arginine: step 2/2 relationship: part_of UPa:UER00365 {cardinality="1", direction="RL", order="1"} ! carbamoyl phosphate from L-arginine: step 2/2 [Term] id: UPa:UCR01399 name: carbamoyl phosphate + putrescine = N-carbamoylputrescine + phosphate namespace: reaction xref: KEGG:R01399 "KEGG reaction" xref: METACYC:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21939 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_input_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00436 ! N-carbamoylputrescine relationship: has_output_compound UPa:UPC00436 {cardinality="1"} ! N-carbamoylputrescine relationship: part_of UPa:UER00941 ! putrescine from N-carbamoylputrescine (transferase route): step 1/1 relationship: part_of UPa:UER00941 {cardinality="1", direction="RL", order="1"} ! putrescine from N-carbamoylputrescine (transferase route): step 1/1 [Term] id: UPa:UCR01401 name: H(2)O + S-methyl-5'-thioadenosine = 5-methylthio-alpha-D-ribose + adenine namespace: reaction xref: KEGG:R01401 "KEGG reaction" xref: METACYC:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13620 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine relationship: has_input_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00147 {cardinality="1"} ! adenine relationship: has_output_compound UPa:UPC00147 ! adenine relationship: has_output_compound UPa:UPC03089 {cardinality="1"} ! 5-methylthio-alpha-D-ribose relationship: has_output_compound UPa:UPC03089 ! 5-methylthio-alpha-D-ribose relationship: part_of UPa:UER00871 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2 relationship: part_of UPa:UER00871 {cardinality="1", direction="LR", order="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2 [Term] id: UPa:UCR01402 name: S-methyl-5'-thioadenosine + phosphate = S-methyl-5-thio-alpha-D-ribose 1-phosphate + adenine namespace: reaction xref: KEGG:R01402 "KEGG reaction" xref: METACYC:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11855 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine relationship: has_input_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00147 {cardinality="1"} ! adenine relationship: has_output_compound UPa:UPC00147 ! adenine relationship: has_output_compound UPa:UPC04188 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC04188 {cardinality="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:UER00873 {cardinality="1", direction="LR", order="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1 relationship: part_of UPa:UER00873 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1 [Term] id: UPa:UCR01416 name: H(2)O + agmatine = N-carbamoylputrescine + NH(3) namespace: reaction xref: KEGG:R01416 "KEGG reaction" xref: METACYC:AGMATINE-DEIMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18040 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00179 ! agmatine relationship: has_input_compound UPa:UPC00179 {cardinality="1"} ! agmatine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00436 {cardinality="1"} ! N-carbamoylputrescine relationship: has_output_compound UPa:UPC00436 ! N-carbamoylputrescine relationship: part_of UPa:UER00285 {cardinality="1", direction="LR", order="1"} ! N-carbamoylputrescine from agmatine: step 1/1 relationship: part_of UPa:UER00285 ! N-carbamoylputrescine from agmatine: step 1/1 [Term] id: UPa:UCR01419 name: H(2)O + NAD(+) + benzaldehyde = H(+) + NADH + benzoate namespace: reaction xref: KEGG:R01419 "KEGG reaction" xref: METACYC:BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11843 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00261 {cardinality="1"} ! benzaldehyde relationship: has_input_compound UPa:UPC00261 ! benzaldehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: has_output_compound UPa:UPC00180 ! benzoate relationship: part_of UPa:UER00988 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00988 ! None [Term] id: UPa:UCR01420 name: H(2)O + NADP(+) + benzaldehyde = H(+) + NADPH + benzoate namespace: reaction xref: KEGG:R01420 "KEGG reaction" xref: METACYC:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21663 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00261 ! benzaldehyde relationship: has_input_compound UPa:UPC00261 {cardinality="1"} ! benzaldehyde relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: has_output_compound UPa:UPC00180 ! benzoate relationship: part_of UPa:UER00987 ! None relationship: part_of UPa:UER00987 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01465 name: L-threonine + NAD(+) = H(+) + L-2-amino-3-oxobutanoic acid + NADH namespace: reaction xref: KEGG:R01465 "KEGG reaction" xref: METACYC:THREODEHYD-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13164 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: has_input_compound UPa:UPC00188 ! L-threonine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03508 {cardinality="1"} ! L-2-amino-3-oxobutanoic acid relationship: has_output_compound UPa:UPC03508 ! L-2-amino-3-oxobutanoic acid relationship: part_of UPa:UER00505 {cardinality="1", direction="LR", order="1"} ! glycine from L-threonine: step 1/2 relationship: part_of UPa:UER00505 ! glycine from L-threonine: step 1/2 [Term] id: UPa:UCR01466 name: H(2)O + O-phospho-L-homoserine = L-threonine + phosphate namespace: reaction xref: KEGG:R01466 "KEGG reaction" xref: METACYC:THRESYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10843 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01102 ! O-phospho-L-homoserine relationship: has_input_compound UPa:UPC01102 {cardinality="1"} ! O-phospho-L-homoserine relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: has_output_compound UPa:UPC00188 ! L-threonine relationship: part_of UPa:UER00065 ! L-threonine from L-aspartate: step 5/5 relationship: part_of UPa:UER00065 {cardinality="1", direction="LR", order="1"} ! L-threonine from L-aspartate: step 5/5 [Term] id: UPa:UCR01468 name: ATP + ethanolamine = ADP + phosphoethanolamine namespace: reaction xref: KEGG:R01468 "KEGG reaction" xref: METACYC:ETHANOLAMINE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13072 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00189 ! ethanolamine relationship: has_input_compound UPa:UPC00189 {cardinality="1"} ! ethanolamine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00346 {cardinality="1"} ! phosphoethanolamine relationship: has_output_compound UPa:UPC00346 ! phosphoethanolamine relationship: part_of UPa:UER00741 ! phosphatidylethanolamine from ethanolamine: step 1/3 relationship: part_of UPa:UER00741 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from ethanolamine: step 1/3 [Term] id: UPa:UCR01473 name: UDP-L-arabinose = UDP-alpha-D-xylose namespace: reaction xref: KEGG:R01473 "KEGG reaction" xref: METACYC:UDP-ARABINOSE-4-EPIMERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11323 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00935 ! UDP-L-arabinose relationship: has_input_compound UPa:UPC00935 {cardinality="1"} ! UDP-L-arabinose relationship: has_output_compound UPa:UPC00190 ! UDP-alpha-D-xylose relationship: has_output_compound UPa:UPC00190 {cardinality="1"} ! UDP-alpha-D-xylose relationship: part_of UPa:UER00772 {cardinality="1", direction="RL", order="1"} ! UDP-L-arabinose from UDP-alpha-D-xylose: step 1/1 relationship: part_of UPa:UER00772 ! UDP-L-arabinose from UDP-alpha-D-xylose: step 1/1 [Term] id: UPa:UCR01481 name: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH namespace: reaction xref: KEGG:R01481 "KEGG reaction" xref: METACYC:GLUCURONATE-REDUCTASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14912 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00800 ! L-gulonate relationship: has_input_compound UPa:UPC00800 {cardinality="1"} ! L-gulonate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00191 {cardinality="1"} ! D-glucuronate relationship: has_output_compound UPa:UPC00191 ! D-glucuronate relationship: part_of UPa:UER00937 ! L-ascorbate from UDP-alpha-D-glucuronate: step 2/4 relationship: part_of UPa:UER00937 {cardinality="1", direction="RL", order="1"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 2/4 [Term] id: UPa:UCR01512 name: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP namespace: reaction xref: KEGG:R01512 "KEGG reaction" xref: METACYC:PHOSGLYPHOS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14804 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: has_input_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00236 {cardinality="1"} ! 3-phospho-D-glyceroyl phosphate relationship: has_output_compound UPa:UPC00236 ! 3-phospho-D-glyceroyl phosphate relationship: part_of UPa:UER00185 {cardinality="1", direction="RL", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 2/5 relationship: part_of UPa:UER00185 ! pyruvate from D-glyceraldehyde 3-phosphate: step 2/5 [Term] id: UPa:UCR01513 name: 3-phospho-D-glycerate + NAD(+) = 3-phosphohydroxypyruvate + H(+) + NADH namespace: reaction xref: KEGG:R01513 "KEGG reaction" xref: METACYC:PGLYCDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12644 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: has_input_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03232 ! 3-phosphohydroxypyruvate relationship: has_output_compound UPa:UPC03232 {cardinality="1"} ! 3-phosphohydroxypyruvate relationship: part_of UPa:UER00196 {cardinality="1", direction="LR", order="1"} ! L-serine from 3-phospho-D-glycerate: step 1/3 relationship: part_of UPa:UER00196 ! L-serine from 3-phospho-D-glycerate: step 1/3 [Term] id: UPa:UCR01514 name: ATP + D-glycerate = 3-phospho-D-glycerate + ADP namespace: reaction xref: KEGG:R01514 "KEGG reaction" xref: METACYC:GLY3KIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23519 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: part_of UPa:UER00833 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycolate: step 4/4 relationship: part_of UPa:UER00833 ! 3-phospho-D-glycerate from glycolate: step 4/4 relationship: part_of UPa:UER00917 ! 3-phospho-D-glycerate from glycine: step 4/4 relationship: part_of UPa:UER00917 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycine: step 4/4 [Term] id: UPa:UCR01518 name: 2-phospho-D-glycerate = 3-phospho-D-glycerate namespace: reaction xref: KEGG:R01518 "KEGG reaction" xref: METACYC:3PGAREARR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15904 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00631 ! 2-phospho-D-glycerate relationship: has_input_compound UPa:UPC00631 {cardinality="1"} ! 2-phospho-D-glycerate relationship: has_output_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: part_of UPa:UER00186 {cardinality="1", direction="RL", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 3/5 relationship: part_of UPa:UER00186 ! pyruvate from D-glyceraldehyde 3-phosphate: step 3/5 [Term] id: UPa:UCR01519 name: D-glucono-1,5-lactone + H(2)O = D-gluconate namespace: reaction xref: KEGG:R01519 "KEGG reaction" xref: METACYC:GLUCONOLACT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10443 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00198 ! D-glucono-1,5-lactone relationship: has_input_compound UPa:UPC00198 {cardinality="1"} ! D-glucono-1,5-lactone relationship: has_output_compound UPa:UPC00257 {cardinality="1"} ! D-gluconate relationship: has_output_compound UPa:UPC00257 ! D-gluconate relationship: part_of UPa:UER00785 ! D-gluconate from D-glucono-1,5-lactone: step 1/1 relationship: part_of UPa:UER00785 {cardinality="1", direction="LR", order="1"} ! D-gluconate from D-glucono-1,5-lactone: step 1/1 [Term] id: UPa:UCR01528 name: 6-phospho-D-gluconate + NADP(+) = CO(2) + D-ribulose 5-phosphate + H(+) + NADPH namespace: reaction xref: KEGG:R01528 "KEGG reaction" xref: METACYC:RXN-9952 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10119 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00345 {cardinality="1"} ! 6-phospho-D-gluconate relationship: has_input_compound UPa:UPC00345 ! 6-phospho-D-gluconate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: part_of UPa:UER00410 {cardinality="1", direction="LR", order="1"} ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3 relationship: part_of UPa:UER00410 ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3 [Term] id: UPa:UCR01529 name: D-ribulose 5-phosphate = D-xylulose 5-phosphate namespace: reaction xref: KEGG:R01529 "KEGG reaction" xref: METACYC:RIBULP3EPIM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13680 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: part_of UPa:UER00411 ! D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1 relationship: part_of UPa:UER00411 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1 [Term] id: UPa:UCR01530 name: D-arabinose 5-phosphate = D-ribulose 5-phosphate namespace: reaction xref: KEGG:R01530 "KEGG reaction" xref: METACYC:DARAB5PISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23107 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01112 {cardinality="1"} ! D-arabinose 5-phosphate relationship: has_input_compound UPa:UPC01112 ! D-arabinose 5-phosphate relationship: has_output_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: part_of UPa:UER00473 ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 1/3 relationship: part_of UPa:UER00473 {cardinality="1", direction="RL", order="1"} ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 1/3 [Term] id: UPa:UCR01541 name: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconic acid + ADP namespace: reaction xref: KEGG:R01541 "KEGG reaction" xref: METACYC:DEOXYGLUCONOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14800 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00204 ! 2-dehydro-3-deoxy-D-gluconate relationship: has_input_compound UPa:UPC00204 {cardinality="1"} ! 2-dehydro-3-deoxy-D-gluconate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04442 ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid relationship: has_output_compound UPa:UPC04442 {cardinality="1"} ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid relationship: part_of UPa:UER00828 ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 1/2 relationship: part_of UPa:UER00828 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 1/2 [Term] id: UPa:UCR01542 name: 2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-hexo-2,5-diulosonate + H(+) + NADH namespace: reaction xref: KEGG:R01542 "KEGG reaction" xref: METACYC:1.1.1.127-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24235 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00204 ! 2-dehydro-3-deoxy-D-gluconate relationship: has_input_compound UPa:UPC00204 {cardinality="1"} ! 2-dehydro-3-deoxy-D-gluconate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04349 ! 3-deoxy-D-glycero-hexo-2,5-diulosonate relationship: has_output_compound UPa:UPC04349 {cardinality="1"} ! 3-deoxy-D-glycero-hexo-2,5-diulosonate relationship: part_of UPa:UER00827 ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 5/5 relationship: part_of UPa:UER00827 {cardinality="1", direction="RL", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 5/5 [Term] id: UPa:UCR01563 name: H(2)O + N-carbamoylsarcosine = CO(2) + NH(3) + sarcosine namespace: reaction xref: KEGG:R01563 "KEGG reaction" xref: METACYC:N-CARBAMOYLSARCOSINE-AMIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20060 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01043 {cardinality="1"} ! N-carbamoylsarcosine relationship: has_input_compound UPa:UPC01043 ! N-carbamoylsarcosine relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00213 ! sarcosine relationship: has_output_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: part_of UPa:UER00397 ! sarcosine from creatinine: step 3/3 relationship: part_of UPa:UER00397 {cardinality="1", direction="LR", order="1"} ! sarcosine from creatinine: step 3/3 [Term] id: UPa:UCR01565 name: H(2)O + N,N-dimethylglycine + electron-transferring flavoprotein = formaldehyde + reduced electron-transferring flavoprotein + sarcosine namespace: reaction xref: KEGG:R01565 "KEGG reaction" xref: METACYC:DIMETHYLGLYCINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22499 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC01026 {cardinality="1"} ! N,N-dimethylglycine relationship: has_input_compound UPa:UPC01026 ! N,N-dimethylglycine relationship: has_input_compound UPa:UPC04253 ! electron-transferring flavoprotein relationship: has_input_compound UPa:UPC04253 {cardinality="1"} ! electron-transferring flavoprotein relationship: has_output_compound UPa:UPC00067 ! formaldehyde relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_output_compound UPa:UPC00213 ! sarcosine relationship: has_output_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: has_output_compound UPa:UPC04570 {cardinality="1"} ! reduced electron-transferring flavoprotein relationship: has_output_compound UPa:UPC04570 ! reduced electron-transferring flavoprotein relationship: part_of UPa:UER00433 ! sarcosine from betaine: step 2/2 relationship: part_of UPa:UER00433 {cardinality="1", direction="LR", order="1"} ! sarcosine from betaine: step 2/2 [Term] id: UPa:UCR01567 name: ATP + thymidine = ADP + dTMP namespace: reaction xref: KEGG:R01567 "KEGG reaction" xref: METACYC:THYKI-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19132 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00214 ! thymidine relationship: has_input_compound UPa:UPC00214 {cardinality="1"} ! thymidine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00364 {cardinality="1"} ! dTMP relationship: has_output_compound UPa:UPC00364 ! dTMP relationship: part_of UPa:UER00639 {cardinality="1", direction="LR", order="1"} ! dTMP from thymine: step 2/2 relationship: part_of UPa:UER00639 ! dTMP from thymine: step 2/2 [Term] id: UPa:UCR01570 name: phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine namespace: reaction xref: KEGG:R01570 "KEGG reaction" xref: METACYC:THYM-PHOSPH-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16040 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00214 ! thymidine relationship: has_input_compound UPa:UPC00214 {cardinality="1"} ! thymidine relationship: has_output_compound UPa:UPC00178 ! thymine relationship: has_output_compound UPa:UPC00178 {cardinality="1"} ! thymine relationship: has_output_compound UPa:UPC00672 ! 2-deoxy-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC00672 {cardinality="1"} ! 2-deoxy-alpha-D-ribose 1-phosphate relationship: part_of UPa:UER00638 ! dTMP from thymine: step 1/2 relationship: part_of UPa:UER00638 {cardinality="1", direction="RL", order="1"} ! dTMP from thymine: step 1/2 [Term] id: UPa:UCR01574 name: D-arabinose + NAD(+) = D-arabinono-1,4-lactone + H(+) + NADH namespace: reaction xref: KEGG:R01574 "KEGG reaction" xref: METACYC:D-ARABINOSE-1-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20460 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00216 ! D-arabinose relationship: has_input_compound UPa:UPC00216 {cardinality="1"} ! D-arabinose relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00652 {cardinality="1"} ! D-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC00652 ! D-arabinono-1,4-lactone relationship: part_of UPa:UER00977 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00977 ! None [Term] id: UPa:UCR01575 name: D-arabinose + NADP(+) = D-arabinono-1,4-lactone + H(+) + NADPH namespace: reaction xref: KEGG:R01575 "KEGG reaction" xref: METACYC:RXN-8776 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21895 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00216 ! D-arabinose relationship: has_input_compound UPa:UPC00216 {cardinality="1"} ! D-arabinose relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00652 {cardinality="1"} ! D-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC00652 ! D-arabinono-1,4-lactone relationship: part_of UPa:UER00978 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00978 ! None [Term] id: UPa:UCR01614 name: 4-coumaroyl-CoA + 3 malonyl-CoA = 3,4',5-trihydroxystilbene + 4 CO(2) + 4 CoA namespace: reaction xref: KEGG:R01614 "KEGG reaction" xref: METACYC:RXN-87 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11939 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00083 ! malonyl-CoA relationship: has_input_compound UPa:UPC00083 {cardinality="1"} ! malonyl-CoA relationship: has_input_compound UPa:UPC00223 {cardinality="1"} ! 4-coumaroyl-CoA relationship: has_input_compound UPa:UPC00223 ! 4-coumaroyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC03582 {cardinality="1"} ! 3,4',5-trihydroxystilbene relationship: has_output_compound UPa:UPC03582 ! 3,4',5-trihydroxystilbene relationship: part_of UPa:UER00548 {cardinality="1", direction="LR", order="1"} ! 3,4',5-trihydroxystilbene from trans-4-coumarate: step 2/2 relationship: part_of UPa:UER00548 ! 3,4',5-trihydroxystilbene from trans-4-coumarate: step 2/2 [Term] id: UPa:UCR01616 name: ATP + CoA + trans-4-coumarate = 4-coumaroyl-CoA + AMP + diphosphate namespace: reaction xref: KEGG:R01616 "KEGG reaction" xref: METACYC:4-COUMARATE--COA-LIGASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19644 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00811 {cardinality="1"} ! trans-4-coumarate relationship: has_input_compound UPa:UPC00811 ! trans-4-coumarate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00223 {cardinality="1"} ! 4-coumaroyl-CoA relationship: has_output_compound UPa:UPC00223 ! 4-coumaroyl-CoA relationship: part_of UPa:UER00547 {cardinality="1", direction="LR", order="1"} ! 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2 relationship: part_of UPa:UER00547 ! 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2 [Term] id: UPa:UCR01620 name: L-lysine + acetyl phosphate = N(6)-acetyl-L-lysine + phosphate namespace: reaction xref: KEGG:R01620 "KEGG reaction" xref: METACYC:LYSINE-N-ACETYLTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14420 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00047 ! L-lysine relationship: has_input_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_input_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate relationship: has_input_compound UPa:UPC00227 ! acetyl phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC02727 {cardinality="1"} ! N(6)-acetyl-L-lysine relationship: has_output_compound UPa:UPC02727 ! N(6)-acetyl-L-lysine relationship: part_of UPa:UER00841 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 1/6 relationship: part_of UPa:UER00841 ! glutarate from L-lysine: step 1/6 [Term] id: UPa:UCR01627 name: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H(2)O namespace: reaction xref: KEGG:R01627 "KEGG reaction" xref: METACYC:DHSHIKIMATE-DEHYDRO-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24851 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02637 ! 3-dehydroshikimate relationship: has_input_compound UPa:UPC02637 {cardinality="1"} ! 3-dehydroshikimate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: part_of UPa:UER00179 ! 3,4-dihydroxybenzoate from 3-dehydroquinate: step 2/2 relationship: part_of UPa:UER00179 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from 3-dehydroquinate: step 2/2 [Term] id: UPa:UCR01629 name: 3,4-dihydroxybenzoate + H(+) + NADH + O(2) = CO(2) + H(2)O + NAD(+) + benzene-1,2,4-triol namespace: reaction xref: KEGG:R01629 "KEGG reaction" xref: RHEA:30038 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_input_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC02814 ! benzene-1,2,4-triol relationship: has_output_compound UPa:UPC02814 {cardinality="1"} ! benzene-1,2,4-triol relationship: part_of UPa:UER00955 ! None relationship: part_of UPa:UER00955 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01630 name: 3,4-dihydroxybenzoate + H(+) + NADPH + O(2) = CO(2) + H(2)O + NADP(+) + benzene-1,2,4-triol namespace: reaction xref: KEGG:R01630 "KEGG reaction" xref: RHEA:30042 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: has_input_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC02814 {cardinality="1"} ! benzene-1,2,4-triol relationship: has_output_compound UPa:UPC02814 ! benzene-1,2,4-triol relationship: part_of UPa:UER00956 ! None relationship: part_of UPa:UER00956 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01631 name: 3,4-dihydroxybenzoate + O(2) = 3-carboxy-cis,cis-muconate namespace: reaction xref: KEGG:R01631 "KEGG reaction" xref: METACYC:PROTOCATECHUATE-34-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10087 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: has_input_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC01163 ! 3-carboxy-cis,cis-muconate relationship: has_output_compound UPa:UPC01163 {cardinality="1"} ! 3-carboxy-cis,cis-muconate relationship: part_of UPa:UER00264 {cardinality="1", direction="LR", order="1"} ! 3-carboxy-cis,cis-muconate from 3,4-dihydroxybenzoate: step 1/1 relationship: part_of UPa:UER00264 ! 3-carboxy-cis,cis-muconate from 3,4-dihydroxybenzoate: step 1/1 [Term] id: UPa:UCR01635 name: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO(2) namespace: reaction xref: KEGG:R01635 "KEGG reaction" xref: METACYC:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24187 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03233 ! 4,5-dihydroxyphthalate relationship: has_input_compound UPa:UPC03233 {cardinality="1"} ! 4,5-dihydroxyphthalate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: part_of UPa:UER00730 ! 3,4-dihydroxybenzoate from phthalate: step 3/3 relationship: part_of UPa:UER00730 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from phthalate: step 3/3 [Term] id: UPa:UCR01639 name: ATP + D-xylulose = ADP + D-xylulose 5-phosphate namespace: reaction xref: KEGG:R01639 "KEGG reaction" xref: METACYC:XYLULOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10967 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00310 {cardinality="1"} ! D-xylulose relationship: has_input_compound UPa:UPC00310 ! D-xylulose relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: part_of UPa:UER00578 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 5/5 relationship: part_of UPa:UER00578 ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 5/5 [Term] id: UPa:UCR01641 name: D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate namespace: reaction xref: KEGG:R01641 "KEGG reaction" xref: METACYC:1TRANSKETO-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10511 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC05382 {cardinality="1"} ! sedoheptulose 7-phosphate relationship: has_input_compound UPa:UPC05382 ! sedoheptulose 7-phosphate relationship: has_output_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: part_of UPa:UER00413 ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 1/3 relationship: part_of UPa:UER00413 {cardinality="1", direction="RL", order="1"} ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 1/3 [Term] id: UPa:UCR01647 name: pyruvate + succinate semialdehyde = 2,4-dihydroxyhept-2-enedioic acid namespace: reaction xref: KEGG:R01647 "KEGG reaction" xref: RHEA:25791 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde relationship: has_input_compound UPa:UPC00232 ! succinate semialdehyde relationship: has_output_compound UPa:UPC06201 {cardinality="1"} ! 2,4-dihydroxyhept-2-enedioic acid relationship: has_output_compound UPa:UPC06201 ! 2,4-dihydroxyhept-2-enedioic acid relationship: part_of UPa:UER00422 {cardinality="1", direction="RL", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 7/7 relationship: part_of UPa:UER00422 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 7/7 [Term] id: UPa:UCR01648 name: 2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde namespace: reaction xref: KEGG:R01648 "KEGG reaction" xref: METACYC:GABATRANSAM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23355 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00334 {cardinality="1"} ! 4-aminobutanoate relationship: has_input_compound UPa:UPC00334 ! 4-aminobutanoate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00232 ! succinate semialdehyde relationship: has_output_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde relationship: part_of UPa:UER00293 {cardinality="1", direction="LR", order="1"} ! succinate semialdehyde from 4-aminobutanoate: step 1/1 relationship: part_of UPa:UER00293 ! succinate semialdehyde from 4-aminobutanoate: step 1/1 [Term] id: UPa:UCR01651 name: 4-methyl-2-oxopentanoate + CoA + NAD(+) = 3-isovaleryl-CoA + CO(2) + H(+) + NADH namespace: reaction xref: KEGG:R01651 "KEGG reaction" xref: METACYC:2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25180 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate relationship: has_input_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC02939 ! 3-isovaleryl-CoA relationship: has_output_compound UPa:UPC02939 {cardinality="1"} ! 3-isovaleryl-CoA relationship: part_of UPa:UER00859 {cardinality="1", direction="LR", order="1"} ! 3-isovaleryl-CoA from 4-methyl-2-oxopentanoate: step 1/1 relationship: part_of UPa:UER00859 ! 3-isovaleryl-CoA from 4-methyl-2-oxopentanoate: step 1/1 [Term] id: UPa:UCR01652 name: 4-methyl-2-oxopentanoate + CO(2) = 3-carboxy-4-methyl-2-oxopentanoate namespace: reaction xref: KEGG:R01652 "KEGG reaction" xref: METACYC:RXN-7800 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25081 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate relationship: has_input_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC04236 ! 3-carboxy-4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC04236 {cardinality="1"} ! 3-carboxy-4-methyl-2-oxopentanoate relationship: part_of UPa:UER00072 ! L-leucine from 3-methyl-2-oxobutanoate: step 3/4 relationship: part_of UPa:UER00072 {cardinality="1", direction="RL", order="2"} ! L-leucine from 3-methyl-2-oxobutanoate: step 3/4 [Term] id: UPa:UCR01658 name: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate namespace: reaction xref: KEGG:R01658 "KEGG reaction" xref: METACYC:GPPSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22411 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00235 {cardinality="1"} ! dimethylallyl diphosphate relationship: has_input_compound UPa:UPC00235 ! dimethylallyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_output_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: part_of UPa:UER00368 {cardinality="1", direction="LR", order="1"} ! geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1 relationship: part_of UPa:UER00368 ! geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1 [Term] id: UPa:UCR01676 name: H(2)O + guanine = NH(3) + xanthine namespace: reaction xref: KEGG:R01676 "KEGG reaction" xref: METACYC:GUANINE-DEAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14668 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00242 ! guanine relationship: has_input_compound UPa:UPC00242 {cardinality="1"} ! guanine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00385 ! xanthine relationship: has_output_compound UPa:UPC00385 {cardinality="1"} ! xanthine relationship: part_of UPa:UER00660 ! xanthine from guanine: step 1/1 relationship: part_of UPa:UER00660 {cardinality="1", direction="LR", order="1"} ! xanthine from guanine: step 1/1 [Term] id: UPa:UCR01681 name: H(2)O + NAD(+) + hypotaurine = H(+) + NADH + taurine namespace: reaction xref: KEGG:R01681 "KEGG reaction" xref: METACYC:HYPOTAURINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17388 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00519 ! hypotaurine relationship: has_input_compound UPa:UPC00519 {cardinality="1"} ! hypotaurine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00245 ! taurine relationship: has_output_compound UPa:UPC00245 {cardinality="1"} ! taurine relationship: part_of UPa:UER00539 ! taurine from hypotaurine: step 1/1 relationship: part_of UPa:UER00539 {cardinality="1", direction="LR", order="1"} ! taurine from hypotaurine: step 1/1 [Term] id: UPa:UCR01682 name: L-cysteate = CO(2) + taurine namespace: reaction xref: KEGG:R01682 "KEGG reaction" xref: METACYC:CYSTAUR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25224 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00506 ! L-cysteate relationship: has_input_compound UPa:UPC00506 {cardinality="1"} ! L-cysteate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00245 ! taurine relationship: has_output_compound UPa:UPC00245 {cardinality="1"} ! taurine relationship: part_of UPa:UER00541 {cardinality="1", direction="LR", order="1"} ! taurine from L-cysteine: step 2/2 relationship: part_of UPa:UER00541 ! taurine from L-cysteine: step 2/2 [Term] id: UPa:UCR01707 name: NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH namespace: reaction xref: KEGG:R01707 "KEGG reaction" xref: METACYC:PYRIDOXAL-4-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21339 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00250 ! pyridoxal relationship: has_input_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00971 {cardinality="1"} ! 4-pyridoxolactone relationship: has_output_compound UPa:UPC00971 ! 4-pyridoxolactone relationship: part_of UPa:UER00588 {cardinality="1", direction="LR", order="1"} ! 4-pyridoxate from pyridoxal: step 1/2 relationship: part_of UPa:UER00588 ! 4-pyridoxate from pyridoxal: step 1/2 [Term] id: UPa:UCR01708 name: NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal namespace: reaction xref: KEGG:R01708 "KEGG reaction" xref: METACYC:PYRIDOXINE-4-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16132 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00314 ! pyridoxine relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: has_output_compound UPa:UPC00250 ! pyridoxal relationship: part_of UPa:UER00307 ! pyridoxal from pyridoxine (dehydrogenase route): step 1/1 relationship: part_of UPa:UER00307 {cardinality="1", direction="LR", order="1"} ! pyridoxal from pyridoxine (dehydrogenase route): step 1/1 [Term] id: UPa:UCR01711 name: O(2) + pyridoxine = H(2)O(2) + pyridoxal namespace: reaction xref: KEGG:R01711 "KEGG reaction" xref: METACYC:PYRIDOXINE-4-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15036 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00314 ! pyridoxine relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00250 ! pyridoxal relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: part_of UPa:UER00590 ! pyridoxal from pyridoxine (oxidase route): step 1/1 relationship: part_of UPa:UER00590 {cardinality="1", direction="LR", order="1"} ! pyridoxal from pyridoxine (oxidase route): step 1/1 [Term] id: UPa:UCR01712 name: pyridoxamine + pyruvate = L-alanine + pyridoxal namespace: reaction xref: KEGG:R01712 "KEGG reaction" xref: METACYC:2.6.1.30-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12844 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00534 ! pyridoxamine relationship: has_input_compound UPa:UPC00534 {cardinality="1"} ! pyridoxamine relationship: has_output_compound UPa:UPC00041 ! L-alanine relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00250 ! pyridoxal relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: part_of UPa:UER00306 ! pyridoxal from pyridoxamine: step 1/1 relationship: part_of UPa:UER00306 {cardinality="1", direction="LR", order="1"} ! pyridoxal from pyridoxamine: step 1/1 [Term] id: UPa:UCR01714 name: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate namespace: reaction xref: KEGG:R01714 "KEGG reaction" xref: METACYC:CHORISMATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21023 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01269 {cardinality="1"} ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate relationship: has_input_compound UPa:UPC01269 ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00251 ! chorismate relationship: has_output_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: part_of UPa:UER00090 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7 relationship: part_of UPa:UER00090 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7 [Term] id: UPa:UCR01715 name: chorismate = prephenate namespace: reaction xref: KEGG:R01715 "KEGG reaction" xref: METACYC:CHORISMATEMUT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13900 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00251 ! chorismate relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: has_output_compound UPa:UPC00254 ! prephenate relationship: has_output_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: part_of UPa:UER00203 ! prephenate from chorismate: step 1/1 relationship: part_of UPa:UER00203 {cardinality="1", direction="LR", order="1"} ! prephenate from chorismate: step 1/1 [Term] id: UPa:UCR01717 name: chorismate = isochorismate namespace: reaction xref: KEGG:R01717 "KEGG reaction" xref: METACYC:ISOCHORSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18988 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00251 ! chorismate relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: has_output_compound UPa:UPC00885 {cardinality="1"} ! isochorismate relationship: has_output_compound UPa:UPC00885 ! isochorismate relationship: part_of UPa:UER00163 ! 1,4-dihydroxy-2-naphthoate from chorismate: step 1/7 relationship: part_of UPa:UER00163 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 1/7 [Term] id: UPa:UCR01720 name: H(2)O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH namespace: reaction xref: KEGG:R01720 "KEGG reaction" xref: METACYC:RXN-7637 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12239 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00253 ! nicotinate relationship: has_input_compound UPa:UPC00253 {cardinality="1"} ! nicotinate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC01020 {cardinality="1"} ! 6-hydroxynicotinate relationship: has_output_compound UPa:UPC01020 ! 6-hydroxynicotinate relationship: part_of UPa:UER01011 {cardinality="1", direction="LR", order="1"} ! 6-hydroxynicotinate from nicotinate: step 1/1 relationship: part_of UPa:UER01011 ! 6-hydroxynicotinate from nicotinate: step 1/1 [Term] id: UPa:UCR01724 name: ADP + diphosphate + nicotinate D-ribonucleotide + phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(+) + H(2)O + nicotinate namespace: reaction xref: KEGG:R01724 "KEGG reaction" xref: METACYC:NICOTINATEPRIBOSYLTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13396 "Rhea reaction" xref: RHEA:36166 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00008 ! ADP relationship: has_input_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC01185 ! nicotinate D-ribonucleotide relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_output_compound UPa:UPC00002 ! ATP relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00253 {cardinality="1"} ! nicotinate relationship: has_output_compound UPa:UPC00253 ! nicotinate relationship: part_of UPa:UER00457 ! nicotinate D-ribonucleotide from nicotinate: step 1/1 relationship: part_of UPa:UER00457 {cardinality="1", direction="RL", order="1"} ! nicotinate D-ribonucleotide from nicotinate: step 1/1 [Term] id: UPa:UCR01728 name: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + H(+) + NADH namespace: reaction xref: KEGG:R01728 "KEGG reaction" xref: METACYC:PREPHENATEDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13872 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate relationship: part_of UPa:UER00961 ! (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1 relationship: part_of UPa:UER00961 {cardinality="1", direction="LR", order="1"} ! (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1 [Term] id: UPa:UCR01730 name: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + H(+) + NADPH namespace: reaction xref: KEGG:R01730 "KEGG reaction" xref: METACYC:PREPHENATE-DEHYDROGENASE-NADP+-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21643 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate relationship: part_of UPa:UER00962 {cardinality="1", direction="LR", order="1"} ! (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1 relationship: part_of UPa:UER00962 ! (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1 [Term] id: UPa:UCR01731 name: L-arogenate + oxaloacetate = L-aspartate + prephenate namespace: reaction xref: KEGG:R01731 "KEGG reaction" xref: METACYC:PREPHENATE-ASP-TRANSAMINE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20448 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: has_input_compound UPa:UPC00036 ! oxaloacetate relationship: has_input_compound UPa:UPC00826 ! L-arogenate relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_output_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: has_output_compound UPa:UPC00254 ! prephenate relationship: part_of UPa:UER00342 ! L-arogenate from prephenate (L-Asp route): step 1/1 relationship: part_of UPa:UER00342 {cardinality="1", direction="RL", order="1"} ! L-arogenate from prephenate (L-Asp route): step 1/1 [Term] id: UPa:UCR01736 name: (R)-S-lactoylglutathione + H(2)O = (R)-lactate + glutathione namespace: reaction xref: KEGG:R01736 "KEGG reaction" xref: METACYC:GLYOXII-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25248 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC03451 {cardinality="1"} ! (R)-S-lactoylglutathione relationship: has_input_compound UPa:UPC03451 ! (R)-S-lactoylglutathione relationship: has_output_compound UPa:UPC00051 ! glutathione relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione relationship: has_output_compound UPa:UPC00256 ! (R)-lactate relationship: has_output_compound UPa:UPC00256 {cardinality="1"} ! (R)-lactate relationship: part_of UPa:UER00676 {cardinality="1", direction="LR", order="1"} ! (R)-lactate from methylglyoxal: step 2/2 relationship: part_of UPa:UER00676 ! (R)-lactate from methylglyoxal: step 2/2 [Term] id: UPa:UCR01745 name: D-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH namespace: reaction xref: KEGG:R01745 "KEGG reaction" xref: METACYC:RXN0-5289 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18848 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate relationship: has_output_compound UPa:UPC01146 {cardinality="1"} ! 2-hydroxy-3-oxopropanoate relationship: part_of UPa:UER00973 ! None relationship: part_of UPa:UER00973 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01747 name: D-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADPH namespace: reaction xref: KEGG:R01747 "KEGG reaction" xref: METACYC:RXN0-5289 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: METACYC:TSA-REDUCT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18844 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate relationship: has_output_compound UPa:UPC01146 {cardinality="1"} ! 2-hydroxy-3-oxopropanoate relationship: part_of UPa:UER00974 ! None relationship: part_of UPa:UER00974 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01749 name: CO(2) + D-glycerate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH namespace: reaction xref: KEGG:R01749 "KEGG reaction" xref: METACYC:1.1.1.92-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:13156 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate relationship: has_output_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate relationship: part_of UPa:UER00981 {cardinality="1", direction="RL", order="1"} ! None relationship: part_of UPa:UER00981 ! None [Term] id: UPa:UCR01750 name: CO(2) + D-glycerate + NADP(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADPH namespace: reaction xref: KEGG:R01750 "KEGG reaction" xref: METACYC:1.1.1.92-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13160 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate relationship: part_of UPa:UER00982 {cardinality="1", direction="RL", order="1"} ! None relationship: part_of UPa:UER00982 ! None [Term] id: UPa:UCR01751 name: L-tartrate = CO(2) + D-glycerate namespace: reaction xref: KEGG:R01751 "KEGG reaction" xref: METACYC:TARTRATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13320 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00898 ! L-tartrate relationship: has_input_compound UPa:UPC00898 {cardinality="1"} ! L-tartrate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: part_of UPa:UER00803 {cardinality="1", direction="LR", order="1"} ! D-glycerate from L-tartrate: step 1/1 relationship: part_of UPa:UER00803 ! D-glycerate from L-tartrate: step 1/1 [Term] id: UPa:UCR01757 name: L-arabinose + NAD(+) = H(+) + L-arabinono-1,4-lactone + NADH namespace: reaction xref: KEGG:R01757 "KEGG reaction" xref: METACYC:L-ARABINOSE-1-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17928 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose relationship: has_input_compound UPa:UPC00259 ! L-arabinose relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01114 ! L-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC01114 {cardinality="1"} ! L-arabinono-1,4-lactone relationship: part_of UPa:UER00568 ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 1/3 relationship: part_of UPa:UER00568 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 1/3 [Term] id: UPa:UCR01758 name: L-arabinitol + NAD(+) = H(+) + L-arabinose + NADH namespace: reaction xref: KEGG:R01758 "KEGG reaction" xref: METACYC:RXN-14102 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:25228 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00532 {cardinality="1"} ! L-arabinitol relationship: has_input_compound UPa:UPC00532 ! L-arabinitol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose relationship: has_output_compound UPa:UPC00259 ! L-arabinose relationship: part_of UPa:UER00969 ! None relationship: part_of UPa:UER00969 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01759 name: L-arabinitol + NADP(+) = H(+) + L-arabinose + NADPH namespace: reaction xref: KEGG:R01759 "KEGG reaction" xref: METACYC:RXN-8772 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25232 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00532 {cardinality="1"} ! L-arabinitol relationship: has_input_compound UPa:UPC00532 ! L-arabinitol relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00259 ! L-arabinose relationship: has_output_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose relationship: part_of UPa:UER00970 ! None relationship: part_of UPa:UER00970 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01761 name: L-arabinose = L-ribulose namespace: reaction xref: KEGG:R01761 "KEGG reaction" xref: METACYC:ARABISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14824 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose relationship: has_input_compound UPa:UPC00259 ! L-arabinose relationship: has_output_compound UPa:UPC00508 {cardinality="1"} ! L-ribulose relationship: has_output_compound UPa:UPC00508 ! L-ribulose relationship: part_of UPa:UER00565 ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3 relationship: part_of UPa:UER00565 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3 [Term] id: UPa:UCR01764 name: phenylglyoxylate = CO(2) + benzaldehyde namespace: reaction xref: KEGG:R01764 "KEGG reaction" xref: METACYC:BENZOYLFORMATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23371 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02137 ! phenylglyoxylate relationship: has_input_compound UPa:UPC02137 {cardinality="1"} ! phenylglyoxylate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00261 ! benzaldehyde relationship: has_output_compound UPa:UPC00261 {cardinality="1"} ! benzaldehyde relationship: part_of UPa:UER00854 {cardinality="1", direction="LR", order="1"} ! benzoate from (R)-mandelate: step 3/4 relationship: part_of UPa:UER00854 ! benzoate from (R)-mandelate: step 3/4 [Term] id: UPa:UCR01768 name: H(2)O + NAD(+) + hypoxanthine = H(+) + NADH + xanthine namespace: reaction xref: KEGG:R01768 "KEGG reaction" xref: METACYC:RXN-7682 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24673 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00262 ! hypoxanthine relationship: has_input_compound UPa:UPC00262 {cardinality="1"} ! hypoxanthine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00385 {cardinality="1"} ! xanthine relationship: has_output_compound UPa:UPC00385 ! xanthine relationship: part_of UPa:UER00661 {cardinality="1", direction="LR", order="1"} ! urate from hypoxanthine: step 1/2 relationship: part_of UPa:UER00661 ! urate from hypoxanthine: step 1/2 [Term] id: UPa:UCR01771 name: ATP + L-homoserine = ADP + O-phospho-L-homoserine namespace: reaction xref: KEGG:R01771 "KEGG reaction" xref: METACYC:HOMOSERKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13988 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: has_input_compound UPa:UPC00263 ! L-homoserine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC01102 ! O-phospho-L-homoserine relationship: has_output_compound UPa:UPC01102 {cardinality="1"} ! O-phospho-L-homoserine relationship: part_of UPa:UER00064 {cardinality="1", direction="LR", order="1"} ! L-threonine from L-aspartate: step 4/5 relationship: part_of UPa:UER00064 ! L-threonine from L-aspartate: step 4/5 [Term] id: UPa:UCR01773 name: L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH namespace: reaction xref: KEGG:R01773 "KEGG reaction" xref: RHEA:15760 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: has_input_compound UPa:UPC00263 ! L-homoserine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: part_of UPa:UER00949 ! None relationship: part_of UPa:UER00949 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01775 name: L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH namespace: reaction xref: KEGG:R01775 "KEGG reaction" xref: METACYC:HOMOSERDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15764 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: has_input_compound UPa:UPC00263 ! L-homoserine relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: part_of UPa:UER00950 {cardinality="1", direction="RL", order="1"} ! None relationship: part_of UPa:UER00950 ! None [Term] id: UPa:UCR01776 name: L-homoserine + acetyl-CoA = CoA + O-acetyl-L-homoserine namespace: reaction xref: KEGG:R01776 "KEGG reaction" xref: METACYC:HOMOSERINE-O-ACETYLTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13704 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: has_input_compound UPa:UPC00263 ! L-homoserine relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC01077 ! O-acetyl-L-homoserine relationship: has_output_compound UPa:UPC01077 {cardinality="1"} ! O-acetyl-L-homoserine relationship: part_of UPa:UER00074 ! O-acetyl-L-homoserine from L-homoserine: step 1/1 relationship: part_of UPa:UER00074 {cardinality="1", direction="LR", order="1"} ! O-acetyl-L-homoserine from L-homoserine: step 1/1 [Term] id: UPa:UCR01777 name: L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine namespace: reaction xref: KEGG:R01777 "KEGG reaction" xref: METACYC:HOMSUCTRAN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22011 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: has_input_compound UPa:UPC00263 ! L-homoserine relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC01118 {cardinality="1"} ! O-succinyl-L-homoserine relationship: has_output_compound UPa:UPC01118 ! O-succinyl-L-homoserine relationship: part_of UPa:UER00075 {cardinality="1", direction="LR", order="1"} ! O-succinyl-L-homoserine from L-homoserine: step 1/1 relationship: part_of UPa:UER00075 ! O-succinyl-L-homoserine from L-homoserine: step 1/1 [Term] id: UPa:UCR01784 name: 2-dehydro-3-deoxy-L-arabinonate = glycolaldehyde + pyruvate namespace: reaction xref: KEGG:R01784 "KEGG reaction" xref: METACYC:4.1.2.18-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18548 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00684 ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_input_compound UPa:UPC00684 {cardinality="1"} ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00266 ! glycolaldehyde relationship: has_output_compound UPa:UPC00266 {cardinality="1"} ! glycolaldehyde relationship: part_of UPa:UER00571 ! glycolaldehyde and pyruvate from 2-dehydro-3-deoxy-L-arabinonate: step 1/1 relationship: part_of UPa:UER00571 {cardinality="1", direction="LR", order="1"} ! glycolaldehyde and pyruvate from 2-dehydro-3-deoxy-L-arabinonate: step 1/1 [Term] id: UPa:UCR01793 name: H(+) + NADH + dihydrobiopterin = NAD(+) + tetrahydrobiopterin namespace: reaction xref: KEGG:R01793 "KEGG reaction" xref: METACYC:1.5.1.34-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: METACYC:RXN-7909 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17872 "Rhea reaction" xref: RHEA:32254 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00268 ! dihydrobiopterin relationship: has_input_compound UPa:UPC00268 {cardinality="1"} ! dihydrobiopterin relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: part_of UPa:UER00993 ! None relationship: part_of UPa:UER00993 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01794 name: H(+) + NADPH + dihydrobiopterin = NADP(+) + tetrahydrobiopterin namespace: reaction xref: KEGG:R01794 "KEGG reaction" xref: RHEA:32250 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00268 ! dihydrobiopterin relationship: has_input_compound UPa:UPC00268 {cardinality="1"} ! dihydrobiopterin relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: part_of UPa:UER00994 ! None relationship: part_of UPa:UER00994 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01797 name: CDP-diacylglycerol + H(2)O = CMP + phosphatidate namespace: reaction xref: KEGG:R01797 "KEGG reaction" xref: METACYC:CDPDIGLYPYPHOSPHA-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15224 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00416 {cardinality="1"} ! phosphatidate relationship: has_output_compound UPa:UPC00416 ! phosphatidate relationship: part_of UPa:UER00664 {cardinality="1", direction="LR", order="1"} ! phosphatidate from CDP-diacylglycerol: step 1/1 relationship: part_of UPa:UER00664 ! phosphatidate from CDP-diacylglycerol: step 1/1 [Term] id: UPa:UCR01799 name: CTP + phosphatidate = CDP-diacylglycerol + diphosphate namespace: reaction xref: KEGG:R01799 "KEGG reaction" xref: METACYC:CDPDIGLYSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16232 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00416 ! phosphatidate relationship: has_input_compound UPa:UPC00416 {cardinality="1"} ! phosphatidate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: part_of UPa:UER00614 ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3 relationship: part_of UPa:UER00614 {cardinality="1", direction="LR", order="1"} ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3 [Term] id: UPa:UCR01800 name: CDP-diacylglycerol + L-serine = CMP + phosphatidylserine namespace: reaction xref: KEGG:R01800 "KEGG reaction" xref: METACYC:PHOSPHASERSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16916 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC02737 ! phosphatidylserine relationship: has_output_compound UPa:UPC02737 {cardinality="1"} ! phosphatidylserine relationship: part_of UPa:UER00615 ! phosphatidylethanolamine from CDP-diacylglycerol: step 1/2 relationship: part_of UPa:UER00615 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from CDP-diacylglycerol: step 1/2 [Term] id: UPa:UCR01801 name: CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + phosphatidylglycerophosphate namespace: reaction xref: KEGG:R01801 "KEGG reaction" xref: METACYC:PHOSPHAGLYPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12596 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC03892 {cardinality="1"} ! phosphatidylglycerophosphate relationship: has_output_compound UPa:UPC03892 ! phosphatidylglycerophosphate relationship: part_of UPa:UER00503 {cardinality="1", direction="LR", order="1"} ! phosphatidylglycerol from CDP-diacylglycerol: step 1/2 relationship: part_of UPa:UER00503 ! phosphatidylglycerol from CDP-diacylglycerol: step 1/2 [Term] id: UPa:UCR01811 name: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate namespace: reaction xref: KEGG:R01811 "KEGG reaction" xref: METACYC:ACNEULY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23299 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00270 ! N-acetylneuraminate relationship: has_input_compound UPa:UPC00270 {cardinality="1"} ! N-acetylneuraminate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00645 {cardinality="1"} ! N-acetyl-D-mannosamine relationship: has_output_compound UPa:UPC00645 ! N-acetyl-D-mannosamine relationship: part_of UPa:UER00680 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 1/5 relationship: part_of UPa:UER00680 ! D-fructose 6-phosphate from N-acetylneuraminate: step 1/5 [Term] id: UPa:UCR01812 name: 2 NADP(+) + tetrahydrobiopterin = 2 H(+) + 2 NADPH + biopterin namespace: reaction xref: KEGG:R01812 "KEGG reaction" xref: METACYC:1.1.1.253-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19512 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: has_input_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC06313 ! biopterin relationship: has_output_compound UPa:UPC06313 {cardinality="1"} ! biopterin relationship: part_of UPa:UER00822 {cardinality="1", direction="RL", order="1"} ! tetrahydrobiopterin from biopterin: step 1/1 relationship: part_of UPa:UER00822 ! tetrahydrobiopterin from biopterin: step 1/1 [Term] id: UPa:UCR01813 name: NADP(+) + tetrahydrobiopterin = 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH namespace: reaction xref: KEGG:R01813 "KEGG reaction" xref: METACYC:RXN-8854 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42503 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_input_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04244 ! 6-lactoyl-5,6,7,8-tetrahydropterin relationship: has_output_compound UPa:UPC04244 {cardinality="1"} ! 6-lactoyl-5,6,7,8-tetrahydropterin relationship: part_of UPa:UER00821 ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 3/3 relationship: part_of UPa:UER00821 {cardinality="1", direction="RL", order="1"} ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 3/3 [Term] id: UPa:UCR01818 name: D-mannose 6-phosphate = alpha-D-mannose 1-phosphate namespace: reaction xref: KEGG:R01818 "KEGG reaction" xref: METACYC:PHOSMANMUT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11143 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00275 {cardinality="1"} ! D-mannose 6-phosphate relationship: has_input_compound UPa:UPC00275 ! D-mannose 6-phosphate relationship: has_output_compound UPa:UPC00636 ! alpha-D-mannose 1-phosphate relationship: has_output_compound UPa:UPC00636 {cardinality="1"} ! alpha-D-mannose 1-phosphate relationship: part_of UPa:UER00424 {cardinality="1", direction="LR", order="1"} ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2 relationship: part_of UPa:UER00424 ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2 [Term] id: UPa:UCR01825 name: D-erythrose 4-phosphate + H(2)O + NAD(+) = 4-phospho-D-erythronate + H(+) + NADH namespace: reaction xref: KEGG:R01825 "KEGG reaction" xref: METACYC:ERYTH4PDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12059 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate relationship: has_input_compound UPa:UPC00279 ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC03393 {cardinality="1"} ! 4-phospho-D-erythronate relationship: has_output_compound UPa:UPC03393 ! 4-phospho-D-erythronate relationship: part_of UPa:UER00309 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5 relationship: part_of UPa:UER00309 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5 [Term] id: UPa:UCR01826 name: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate namespace: reaction xref: KEGG:R01826 "KEGG reaction" xref: METACYC:DAHPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14720 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate relationship: has_input_compound UPa:UPC00279 ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC04691 {cardinality="1"} ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate relationship: has_output_compound UPa:UPC04691 ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate relationship: part_of UPa:UER00084 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7 relationship: part_of UPa:UER00084 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7 [Term] id: UPa:UCR01827 name: D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate namespace: reaction xref: KEGG:R01827 "KEGG reaction" xref: METACYC:TRANSALDOL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17056 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC05382 ! sedoheptulose 7-phosphate relationship: has_input_compound UPa:UPC05382 {cardinality="1"} ! sedoheptulose 7-phosphate relationship: has_output_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00279 ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC05345 {cardinality="1"} ! beta-D-fructose 6-phosphate relationship: has_output_compound UPa:UPC05345 ! beta-D-fructose 6-phosphate relationship: part_of UPa:UER00414 ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3 relationship: part_of UPa:UER00414 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3 [Term] id: UPa:UCR01830 name: D-glyceraldehyde 3-phosphate + beta-D-fructose 6-phosphate = D-erythrose 4-phosphate + D-xylulose 5-phosphate namespace: reaction xref: KEGG:R01830 "KEGG reaction" xref: METACYC:2TRANSKETO-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:27629 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC05345 {cardinality="1"} ! beta-D-fructose 6-phosphate relationship: has_input_compound UPa:UPC05345 ! beta-D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00279 ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate relationship: part_of UPa:UER00415 ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 3/3 relationship: part_of UPa:UER00415 {cardinality="1", direction="RL", order="1"} ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 3/3 [Term] id: UPa:UCR01859 name: ATP + bicarbonate + propanoyl-CoA = (S)-methylmalonyl-CoA + ADP + phosphate namespace: reaction xref: KEGG:R01859 "KEGG reaction" xref: METACYC:PROPIONYL-COA-CARBOXY-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23723 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00100 ! propanoyl-CoA relationship: has_input_compound UPa:UPC00100 {cardinality="1"} ! propanoyl-CoA relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00683 {cardinality="1"} ! (S)-methylmalonyl-CoA relationship: has_output_compound UPa:UPC00683 ! (S)-methylmalonyl-CoA relationship: part_of UPa:UER00908 ! succinyl-CoA from propanoyl-CoA: step 1/3 relationship: part_of UPa:UER00908 {cardinality="1", direction="LR", order="1"} ! succinyl-CoA from propanoyl-CoA: step 1/3 [Term] id: UPa:UCR01867 name: (S)-dihydroorotate + fumarate = orotate + succinate namespace: reaction xref: KEGG:R01867 "KEGG reaction" xref: METACYC:RXN-9929 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15444 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: has_input_compound UPa:UPC00122 ! fumarate relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate relationship: has_output_compound UPa:UPC00295 ! orotate relationship: part_of UPa:UER00118 {cardinality="1", direction="LR", order="1"} ! orotate from (S)-dihydroorotate (O2 route): step 1/1 relationship: part_of UPa:UER00118 ! orotate from (S)-dihydroorotate (O2 route): step 1/1 [Term] id: UPa:UCR01868 name: (S)-dihydroorotate + Quinone = Hydroquinone + orotate namespace: reaction xref: KEGG:R01868 "KEGG reaction" xref: METACYC:DIHYDROOROTATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18076 "Rhea reaction" xref: RHEA:30190 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC15602 ! Quinone relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate relationship: has_output_compound UPa:UPC00295 ! orotate relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone relationship: has_output_compound UPa:UPC15603 ! Hydroquinone relationship: part_of UPa:UER00946 ! orotate from (S)-dihydroorotate (quinone route): step 1/1 relationship: part_of UPa:UER00946 {cardinality="1", direction="LR", order="1"} ! orotate from (S)-dihydroorotate (quinone route): step 1/1 [Term] id: UPa:UCR01869 name: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate namespace: reaction xref: KEGG:R01869 "KEGG reaction" xref: METACYC:OROTATE-REDUCTASE-NADH-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13516 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate relationship: has_output_compound UPa:UPC00295 ! orotate relationship: part_of UPa:UER00945 ! orotate from (S)-dihydroorotate (NAD(+) route): step 1/1 relationship: part_of UPa:UER00945 {cardinality="1", direction="LR", order="1"} ! orotate from (S)-dihydroorotate (NAD(+) route): step 1/1 [Term] id: UPa:UCR01870 name: diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate namespace: reaction xref: KEGG:R01870 "KEGG reaction" xref: METACYC:OROPRIBTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10383 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC01103 ! orotidine 5'-phosphate relationship: has_input_compound UPa:UPC01103 {cardinality="1"} ! orotidine 5'-phosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate relationship: has_output_compound UPa:UPC00295 ! orotate relationship: part_of UPa:UER00119 {cardinality="1", direction="RL", order="1"} ! UMP from orotate: step 1/2 relationship: part_of UPa:UER00119 ! UMP from orotate: step 1/2 [Term] id: UPa:UCR01872 name: D-quinate + NAD(+) = 3-dehydroquinate + H(+) + NADH namespace: reaction xref: KEGG:R01872 "KEGG reaction" xref: METACYC:QUINATE-5-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: METACYC:RXN-7967 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:22367 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00296 {cardinality="1"} ! D-quinate relationship: has_input_compound UPa:UPC00296 ! D-quinate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00944 ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate relationship: part_of UPa:UER00176 ! 3-dehydroquinate from D-quinate (NAD(+) route): step 1/1 relationship: part_of UPa:UER00176 {cardinality="1", direction="LR", order="1"} ! 3-dehydroquinate from D-quinate (NAD(+) route): step 1/1 [Term] id: UPa:UCR01873 name: D-quinate + pyrroloquinoline quinone = 3-dehydroquinate + pyrroloquinoline quinol namespace: reaction xref: KEGG:R01873 "KEGG reaction" xref: METACYC:1.1.99.25-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23675 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00113 {cardinality="1"} ! pyrroloquinoline quinone relationship: has_input_compound UPa:UPC00113 ! pyrroloquinoline quinone relationship: has_input_compound UPa:UPC00296 {cardinality="1"} ! D-quinate relationship: has_input_compound UPa:UPC00296 ! D-quinate relationship: has_output_compound UPa:UPC00944 ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC01359 {cardinality="1"} ! pyrroloquinoline quinol relationship: has_output_compound UPa:UPC01359 ! pyrroloquinoline quinol relationship: part_of UPa:UER00177 ! 3-dehydroquinate from D-quinate (PQQ route): step 1/1 relationship: part_of UPa:UER00177 {cardinality="1", direction="LR", order="1"} ! 3-dehydroquinate from D-quinate (PQQ route): step 1/1 [Term] id: UPa:UCR01876 name: phosphate + uridine = alpha-D-ribose 1-phosphate + uracil namespace: reaction xref: KEGG:R01876 "KEGG reaction" xref: METACYC:URPHOS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24391 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00299 {cardinality="1"} ! uridine relationship: has_input_compound UPa:UPC00299 ! uridine relationship: has_output_compound UPa:UPC00106 ! uracil relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: has_output_compound UPa:UPC00620 {cardinality="1"} ! alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC00620 ! alpha-D-ribose 1-phosphate relationship: part_of UPa:UER00633 {cardinality="1", direction="LR", order="1"} ! uracil from uridine (phosphorylase route): step 1/1 relationship: part_of UPa:UER00633 ! uracil from uridine (phosphorylase route): step 1/1 [Term] id: UPa:UCR01878 name: H(2)O + cytidine = NH(3) + uridine namespace: reaction xref: KEGG:R01878 "KEGG reaction" xref: METACYC:CYTIDEAM2-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16072 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00475 {cardinality="1"} ! cytidine relationship: has_input_compound UPa:UPC00475 ! cytidine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00299 ! uridine relationship: has_output_compound UPa:UPC00299 {cardinality="1"} ! uridine relationship: part_of UPa:UER00632 {cardinality="1", direction="LR", order="1"} ! uridine from cytidine: step 1/1 relationship: part_of UPa:UER00632 ! uridine from cytidine: step 1/1 [Term] id: UPa:UCR01883 name: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine namespace: reaction xref: KEGG:R01883 "KEGG reaction" xref: METACYC:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10659 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00581 ! guanidinoacetate relationship: has_input_compound UPa:UPC00581 {cardinality="1"} ! guanidinoacetate relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00300 {cardinality="1"} ! creatine relationship: has_output_compound UPa:UPC00300 ! creatine relationship: part_of UPa:UER00580 {cardinality="1", direction="LR", order="1"} ! creatine from L-arginine and glycine: step 2/2 relationship: part_of UPa:UER00580 ! creatine from L-arginine and glycine: step 2/2 [Term] id: UPa:UCR01890 name: CTP + phosphocholine = CDP-choline + diphosphate namespace: reaction xref: KEGG:R01890 "KEGG reaction" xref: METACYC:2.7.7.15-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19000 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00588 ! phosphocholine relationship: has_input_compound UPa:UPC00588 {cardinality="1"} ! phosphocholine relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00307 ! CDP-choline relationship: has_output_compound UPa:UPC00307 {cardinality="1"} ! CDP-choline relationship: part_of UPa:UER00739 {cardinality="1", direction="LR", order="1"} ! phosphatidylcholine from phosphocholine: step 1/2 relationship: part_of UPa:UER00739 ! phosphatidylcholine from phosphocholine: step 1/2 [Term] id: UPa:UCR01896 name: NAD(+) + xylitol = D-xylulose + H(+) + NADH namespace: reaction xref: KEGG:R01896 "KEGG reaction" xref: METACYC:D-XYLULOSE-REDUCTASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20436 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00379 {cardinality="1"} ! xylitol relationship: has_input_compound UPa:UPC00379 ! xylitol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00310 ! D-xylulose relationship: has_output_compound UPa:UPC00310 {cardinality="1"} ! D-xylulose relationship: part_of UPa:UER00577 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5 relationship: part_of UPa:UER00577 ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5 [Term] id: UPa:UCR01900 name: isocitrate = H(2)O + cis-aconitate namespace: reaction xref: KEGG:R01900 "KEGG reaction" xref: METACYC:ACONITATEHYDR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22147 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00311 ! isocitrate relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00417 {cardinality="1"} ! cis-aconitate relationship: has_output_compound UPa:UPC00417 ! cis-aconitate relationship: part_of UPa:UER00718 {cardinality="1", direction="RL", order="2"} ! isocitrate from oxaloacetate: step 2/2 relationship: part_of UPa:UER00718 ! isocitrate from oxaloacetate: step 2/2 [Term] id: UPa:UCR01903 name: L-arabinitol + NAD(+) = H(+) + L-xylulose + NADH namespace: reaction xref: KEGG:R01903 "KEGG reaction" xref: METACYC:L-ARABINITOL-4-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16384 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00532 ! L-arabinitol relationship: has_input_compound UPa:UPC00532 {cardinality="1"} ! L-arabinitol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00312 ! L-xylulose relationship: has_output_compound UPa:UPC00312 {cardinality="1"} ! L-xylulose relationship: part_of UPa:UER00575 ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5 relationship: part_of UPa:UER00575 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5 [Term] id: UPa:UCR01904 name: NADP(+) + xylitol = H(+) + L-xylulose + NADPH namespace: reaction xref: KEGG:R01904 "KEGG reaction" xref: METACYC:L-XYLULOSE-REDUCTASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17028 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00379 {cardinality="1"} ! xylitol relationship: has_input_compound UPa:UPC00379 ! xylitol relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00312 ! L-xylulose relationship: has_output_compound UPa:UPC00312 {cardinality="1"} ! L-xylulose relationship: part_of UPa:UER00576 ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 3/5 relationship: part_of UPa:UER00576 {cardinality="1", direction="RL", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 3/5 [Term] id: UPa:UCR01908 name: oxalyl-CoA = CO(2) + formyl-CoA namespace: reaction xref: KEGG:R01908 "KEGG reaction" xref: METACYC:OXALYL-COA-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19336 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00313 {cardinality="1"} ! oxalyl-CoA relationship: has_input_compound UPa:UPC00313 ! oxalyl-CoA relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00798 ! formyl-CoA relationship: has_output_compound UPa:UPC00798 {cardinality="1"} ! formyl-CoA relationship: part_of UPa:UER00599 ! CO(2) and formate from oxalate: step 2/2 relationship: part_of UPa:UER00599 {cardinality="1", direction="LR", order="1"} ! CO(2) and formate from oxalate: step 2/2 [Term] id: UPa:UCR01909 name: ATP + pyridoxine = ADP + pyridoxine 5'-phosphate namespace: reaction xref: KEGG:R01909 "KEGG reaction" xref: METACYC:PNKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25111 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine relationship: has_input_compound UPa:UPC00314 ! pyridoxine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00627 ! pyridoxine 5'-phosphate relationship: part_of UPa:UER00300 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from pyridoxine: step 1/1 relationship: part_of UPa:UER00300 ! pyridoxine 5'-phosphate from pyridoxine: step 1/1 [Term] id: UPa:UCR01911 name: phosphate + pyridoxine = H(2)O + pyridoxine 5'-phosphate namespace: reaction xref: KEGG:R01911 "KEGG reaction" xref: RHEA:25115 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00314 ! pyridoxine relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00627 ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate relationship: part_of UPa:UER00303 ! pyridoxine from pyridoxine 5'-phosphate: step 1/1 relationship: part_of UPa:UER00303 {cardinality="1", direction="RL", order="1"} ! pyridoxine from pyridoxine 5'-phosphate: step 1/1 [Term] id: UPa:UCR01915 name: H(2)O + acceptor + spermidine = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor namespace: reaction xref: KEGG:R01915 "KEGG reaction" xref: METACYC:SPERMIDINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14276 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00315 {cardinality="1"} ! spermidine relationship: has_input_compound UPa:UPC00315 ! spermidine relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal relationship: has_output_compound UPa:UPC00555 ! 4-aminobutanal relationship: has_output_compound UPa:UPC00986 ! 1,3-diaminopropane relationship: has_output_compound UPa:UPC00986 {cardinality="1"} ! 1,3-diaminopropane relationship: part_of UPa:UER00291 {cardinality="1", direction="LR", order="1"} ! 1,3-diaminopropane and 4-aminobutanal from spermidine: step 1/1 relationship: part_of UPa:UER00291 ! 1,3-diaminopropane and 4-aminobutanal from spermidine: step 1/1 [Term] id: UPa:UCR01920 name: S-adenosylmethioninamine + putrescine = S-methyl-5'-thioadenosine + spermidine namespace: reaction xref: KEGG:R01920 "KEGG reaction" xref: METACYC:SPERMIDINESYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12724 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_input_compound UPa:UPC01137 {cardinality="1"} ! S-adenosylmethioninamine relationship: has_input_compound UPa:UPC01137 ! S-adenosylmethioninamine relationship: has_output_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00315 ! spermidine relationship: has_output_compound UPa:UPC00315 {cardinality="1"} ! spermidine relationship: part_of UPa:UER00314 ! spermidine from putrescine: step 1/1 relationship: part_of UPa:UER00314 {cardinality="1", direction="LR", order="1"} ! spermidine from putrescine: step 1/1 [Term] id: UPa:UCR01936 name: 2-oxaloglutaric acid = 2-oxoadipate + CO(2) namespace: reaction xref: KEGG:R01936 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC05533 {cardinality="1"} ! 2-oxaloglutaric acid relationship: has_input_compound UPa:UPC05533 ! 2-oxaloglutaric acid relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00322 {cardinality="1"} ! 2-oxoadipate relationship: has_output_compound UPa:UPC00322 ! 2-oxoadipate relationship: part_of UPa:UER00030 {cardinality="1", direction="LR", order="2"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 4/5 relationship: part_of UPa:UER00030 ! L-alpha-aminoadipate from 2-oxoglutarate: step 4/5 [Term] id: UPa:UCR01939 name: 2-oxoglutarate + L-alpha-aminoadipate = 2-oxoadipate + L-glutamate namespace: reaction xref: KEGG:R01939 "KEGG reaction" xref: METACYC:2-AMINOADIPATE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12604 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00322 {cardinality="1"} ! 2-oxoadipate relationship: has_output_compound UPa:UPC00322 ! 2-oxoadipate relationship: part_of UPa:UER00031 {cardinality="1", direction="RL", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 5/5 relationship: part_of UPa:UER00031 ! L-alpha-aminoadipate from 2-oxoglutarate: step 5/5 relationship: part_of UPa:UER00838 ! glutaryl-CoA from L-lysine: step 4/6 relationship: part_of UPa:UER00838 {cardinality="1", direction="LR", order="1"} ! glutaryl-CoA from L-lysine: step 4/6 [Term] id: UPa:UCR01940 name: 2-oxoadipate + Enzyme N6-(lipoyl)lysine = CO(2) + S(8)-glutaryldihydrolipoamide namespace: reaction xref: KEGG:R01940 "KEGG reaction" xref: RHEA:12191 "Rhea reaction" xref: RHEA:15216 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00322 {cardinality="1"} ! 2-oxoadipate relationship: has_input_compound UPa:UPC00322 ! 2-oxoadipate relationship: has_input_compound UPa:UPC15972 ! Enzyme N6-(lipoyl)lysine relationship: has_input_compound UPa:UPC15972 {cardinality="1"} ! Enzyme N6-(lipoyl)lysine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC06157 {cardinality="1"} ! S(8)-glutaryldihydrolipoamide relationship: has_output_compound UPa:UPC06157 ! S(8)-glutaryldihydrolipoamide relationship: part_of UPa:UER00839 ! glutaryl-CoA from L-lysine: step 5/6 relationship: part_of UPa:UER00839 {cardinality="1", direction="LR", order="1"} ! glutaryl-CoA from L-lysine: step 5/6 [Term] id: UPa:UCR01954 name: ATP + L-aspartate + L-citrulline = (N(omega)-L-arginino)succinate + AMP + diphosphate namespace: reaction xref: KEGG:R01954 "KEGG reaction" xref: METACYC:ARGSUCCINSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10935 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00327 ! L-citrulline relationship: has_input_compound UPa:UPC00327 {cardinality="1"} ! L-citrulline relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC03406 ! (N(omega)-L-arginino)succinate relationship: has_output_compound UPa:UPC03406 {cardinality="1"} ! (N(omega)-L-arginino)succinate relationship: part_of UPa:UER00113 ! L-arginine from L-ornithine and carbamoyl phosphate: step 2/3 relationship: part_of UPa:UER00113 {cardinality="1", direction="LR", order="1"} ! L-arginine from L-ornithine and carbamoyl phosphate: step 2/3 relationship: part_of UPa:UER00272 {cardinality="1", direction="LR", order="1"} ! (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1 relationship: part_of UPa:UER00272 ! (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1 [Term] id: UPa:UCR01956 name: 2-oxoglutarate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate namespace: reaction xref: KEGG:R01956 "KEGG reaction" xref: METACYC:2.6.1.7-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20967 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00328 ! L-kynurenine relationship: has_input_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC01252 ! 4-(2-aminophenyl)-2,4-dioxobutanoate relationship: has_output_compound UPa:UPC01252 {cardinality="1"} ! 4-(2-aminophenyl)-2,4-dioxobutanoate relationship: part_of UPa:UER00726 {cardinality="1", direction="LR", order="1"} ! kynurenate from L-kynurenine: step 1/2 relationship: part_of UPa:UER00726 ! kynurenate from L-kynurenine: step 1/2 [Term] id: UPa:UCR01959 name: H(2)O + N-formyl-N-kynurenine = L-kynurenine + formate namespace: reaction xref: KEGG:R01959 "KEGG reaction" xref: METACYC:ARYLFORMAMIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13012 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC02700 ! N-formyl-N-kynurenine relationship: has_input_compound UPa:UPC02700 {cardinality="1"} ! N-formyl-N-kynurenine relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine relationship: has_output_compound UPa:UPC00328 ! L-kynurenine relationship: part_of UPa:UER00454 ! L-kynurenine from L-tryptophan: step 2/2 relationship: part_of UPa:UER00454 {cardinality="1", direction="LR", order="1"} ! L-kynurenine from L-tryptophan: step 2/2 [Term] id: UPa:UCR01960 name: H(+) + L-kynurenine + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+) namespace: reaction xref: KEGG:R01960 "KEGG reaction" xref: METACYC:KYNURENINE-3-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20548 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine relationship: has_input_compound UPa:UPC00328 ! L-kynurenine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC03227 {cardinality="1"} ! 3-hydroxy-L-kynurenine relationship: has_output_compound UPa:UPC03227 ! 3-hydroxy-L-kynurenine relationship: part_of UPa:UER00328 ! quinolinate from L-kynurenine: step 1/3 relationship: part_of UPa:UER00328 {cardinality="1", direction="LR", order="1"} ! quinolinate from L-kynurenine: step 1/3 [Term] id: UPa:UCR01978 name: (S)-3-hydroxy-3-methylglutaryl-CoA + CoA = H(2)O + acetoacetyl-CoA + acetyl-CoA namespace: reaction xref: KEGG:R01978 "KEGG reaction" xref: METACYC:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10191 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_input_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00332 {cardinality="1"} ! acetoacetyl-CoA relationship: has_output_compound UPa:UPC00332 ! acetoacetyl-CoA relationship: part_of UPa:UER00102 {cardinality="1", direction="RL", order="1"} ! (R)-mevalonate from acetyl-CoA: step 2/3 relationship: part_of UPa:UER00102 ! (R)-mevalonate from acetyl-CoA: step 2/3 [Term] id: UPa:UCR01993 name: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate namespace: reaction xref: KEGG:R01993 "KEGG reaction" xref: METACYC:DIHYDROOROT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24299 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00438 {cardinality="1"} ! N-carbamoyl-L-aspartate relationship: has_output_compound UPa:UPC00438 ! N-carbamoyl-L-aspartate relationship: part_of UPa:UER00117 ! (S)-dihydroorotate from bicarbonate: step 3/3 relationship: part_of UPa:UER00117 {cardinality="1", direction="RL", order="1"} ! (S)-dihydroorotate from bicarbonate: step 3/3 [Term] id: UPa:UCR02003 name: geranyl diphosphate + isopentenyl diphosphate = diphosphate + farnesyl diphosphate namespace: reaction xref: KEGG:R02003 "KEGG reaction" xref: METACYC:FPPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19364 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00448 ! farnesyl diphosphate relationship: part_of UPa:UER00369 {cardinality="1", direction="LR", order="1"} ! farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1 relationship: part_of UPa:UER00369 ! farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1 [Term] id: UPa:UCR02013 name: geranyl diphosphate = (4S)-limonene + diphosphate namespace: reaction xref: KEGG:R02013 "KEGG reaction" xref: METACYC:4.2.3.16-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12872 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00521 {cardinality="1"} ! (4S)-limonene relationship: has_output_compound UPa:UPC00521 ! (4S)-limonene relationship: part_of UPa:UER00925 {cardinality="1", direction="LR", order="1"} ! (4S)-limonene from geranyl diphosphate: step 1/1 relationship: part_of UPa:UER00925 ! (4S)-limonene from geranyl diphosphate: step 1/1 [Term] id: UPa:UCR02021 name: 3'-phospho-5'-adenylyl sulfate + thioredoxin = adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide namespace: reaction xref: KEGG:R02021 "KEGG reaction" xref: METACYC:1.8.4.8-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11727 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00053 {cardinality="1"} ! 3'-phospho-5'-adenylyl sulfate relationship: has_input_compound UPa:UPC00053 ! 3'-phospho-5'-adenylyl sulfate relationship: has_input_compound UPa:UPC00342 ! thioredoxin relationship: has_input_compound UPa:UPC00342 {cardinality="1"} ! thioredoxin relationship: has_output_compound UPa:UPC00054 {cardinality="1"} ! adenosine 3',5'-bisphosphate relationship: has_output_compound UPa:UPC00054 ! adenosine 3',5'-bisphosphate relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_output_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC00343 ! thioredoxin disulfide relationship: has_output_compound UPa:UPC00343 {cardinality="1"} ! thioredoxin disulfide relationship: part_of UPa:UER00206 ! sulfite from sulfate: step 3/3 relationship: part_of UPa:UER00206 {cardinality="1", direction="LR", order="1"} ! sulfite from sulfate: step 3/3 [Term] id: UPa:UCR02029 name: H(2)O + phosphatidylglycerophosphate = phosphate + phosphatidylglycerol namespace: reaction xref: KEGG:R02029 "KEGG reaction" xref: METACYC:PGPPHOSPHA-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:33754 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC03892 {cardinality="1"} ! phosphatidylglycerophosphate relationship: has_input_compound UPa:UPC03892 ! phosphatidylglycerophosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00344 ! phosphatidylglycerol relationship: has_output_compound UPa:UPC00344 {cardinality="1"} ! phosphatidylglycerol relationship: part_of UPa:UER00504 {cardinality="1", direction="LR", order="1"} ! phosphatidylglycerol from CDP-diacylglycerol: step 2/2 relationship: part_of UPa:UER00504 ! phosphatidylglycerol from CDP-diacylglycerol: step 2/2 [Term] id: UPa:UCR02035 name: D-glucono-1,5-lactone 6-phosphate + H(2)O = 6-phospho-D-gluconate namespace: reaction xref: KEGG:R02035 "KEGG reaction" xref: METACYC:6PGLUCONOLACT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12559 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01236 {cardinality="1"} ! D-glucono-1,5-lactone 6-phosphate relationship: has_input_compound UPa:UPC01236 ! D-glucono-1,5-lactone 6-phosphate relationship: has_output_compound UPa:UPC00345 {cardinality="1"} ! 6-phospho-D-gluconate relationship: has_output_compound UPa:UPC00345 ! 6-phospho-D-gluconate relationship: part_of UPa:UER00409 ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3 relationship: part_of UPa:UER00409 {cardinality="1", direction="LR", order="1"} ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3 [Term] id: UPa:UCR02037 name: S-adenosyl-L-methionine + phosphoethanolamine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R02037 "KEGG reaction" xref: METACYC:2.1.1.103-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20368 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00346 {cardinality="1"} ! phosphoethanolamine relationship: has_input_compound UPa:UPC00346 ! phosphoethanolamine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC01210 ! N-methylethanolamine phosphate relationship: has_output_compound UPa:UPC01210 {cardinality="1"} ! N-methylethanolamine phosphate relationship: part_of UPa:UER00738 {cardinality="1", direction="LR", order="1"} ! phosphocholine from phosphoethanolamine: step 1/1 relationship: part_of UPa:UER00738 ! phosphocholine from phosphoethanolamine: step 1/1 [Term] id: UPa:UCR02038 name: CTP + phosphoethanolamine = CDP-ethanolamine + diphosphate namespace: reaction xref: KEGG:R02038 "KEGG reaction" xref: METACYC:2.7.7.14-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24595 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00346 {cardinality="1"} ! phosphoethanolamine relationship: has_input_compound UPa:UPC00346 ! phosphoethanolamine relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00570 {cardinality="1"} ! CDP-ethanolamine relationship: has_output_compound UPa:UPC00570 ! CDP-ethanolamine relationship: part_of UPa:UER00742 ! phosphatidylethanolamine from ethanolamine: step 2/3 relationship: part_of UPa:UER00742 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from ethanolamine: step 2/3 [Term] id: UPa:UCR02055 name: phosphatidylserine = CO(2) + phosphatidylethanolamine namespace: reaction xref: KEGG:R02055 "KEGG reaction" xref: METACYC:PHOSPHASERDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20831 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02737 ! phosphatidylserine relationship: has_input_compound UPa:UPC02737 {cardinality="1"} ! phosphatidylserine relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00350 {cardinality="1"} ! phosphatidylethanolamine relationship: has_output_compound UPa:UPC00350 ! phosphatidylethanolamine relationship: part_of UPa:UER00616 ! phosphatidylethanolamine from CDP-diacylglycerol: step 2/2 relationship: part_of UPa:UER00616 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from CDP-diacylglycerol: step 2/2 [Term] id: UPa:UCR02057 name: 1,2-diacyl-sn-glycerol + CDP-ethanolamine = CMP + phosphatidylethanolamine namespace: reaction xref: KEGG:R02057 "KEGG reaction" xref: METACYC:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:32946 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00570 ! CDP-ethanolamine relationship: has_input_compound UPa:UPC00570 {cardinality="1"} ! CDP-ethanolamine relationship: has_input_compound UPa:UPC00641 {cardinality="1"} ! 1,2-diacyl-sn-glycerol relationship: has_input_compound UPa:UPC00641 ! 1,2-diacyl-sn-glycerol relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00350 {cardinality="1"} ! phosphatidylethanolamine relationship: has_output_compound UPa:UPC00350 ! phosphatidylethanolamine relationship: part_of UPa:UER00743 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from ethanolamine: step 3/3 relationship: part_of UPa:UER00743 ! phosphatidylethanolamine from ethanolamine: step 3/3 [Term] id: UPa:UCR02058 name: acetyl-CoA + alpha-D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate namespace: reaction xref: KEGG:R02058 "KEGG reaction" xref: METACYC:GLUCOSAMINEPNACETYLTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10295 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: has_input_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00357 {cardinality="1"} ! N-acetyl-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00357 ! N-acetyl-D-glucosamine 6-phosphate relationship: part_of UPa:UER00529 {cardinality="1", direction="LR", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2 relationship: part_of UPa:UER00529 ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2 [Term] id: UPa:UCR02059 name: H(2)O + N-acetyl-D-glucosamine 6-phosphate = acetate + alpha-D-glucosamine 6-phosphate namespace: reaction xref: KEGG:R02059 "KEGG reaction" xref: METACYC:NAG6PDEACET-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22939 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00357 ! N-acetyl-D-glucosamine 6-phosphate relationship: has_input_compound UPa:UPC00357 {cardinality="1"} ! N-acetyl-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: part_of UPa:UER00683 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 4/5 relationship: part_of UPa:UER00683 ! D-fructose 6-phosphate from N-acetylneuraminate: step 4/5 [Term] id: UPa:UCR02060 name: alpha-D-glucosamine 1-phosphate = alpha-D-glucosamine 6-phosphate namespace: reaction xref: KEGG:R02060 "KEGG reaction" xref: METACYC:5.4.2.10-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23427 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06156 ! alpha-D-glucosamine 1-phosphate relationship: has_input_compound UPa:UPC06156 {cardinality="1"} ! alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: part_of UPa:UER00531 {cardinality="1", direction="RL", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 1/2 relationship: part_of UPa:UER00531 ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 1/2 [Term] id: UPa:UCR02061 name: farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate namespace: reaction xref: KEGG:R02061 "KEGG reaction" xref: METACYC:FARNESYLTRANSTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17656 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC00353 ! geranylgeranyl diphosphate relationship: part_of UPa:UER00564 {cardinality="1", direction="LR", order="1"} ! geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1 relationship: part_of UPa:UER00564 ! geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1 [Term] id: UPa:UCR02065 name: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate namespace: reaction xref: KEGG:R02065 "KEGG reaction" xref: METACYC:2.5.1.32-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22299 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate relationship: has_input_compound UPa:UPC00353 ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC03427 {cardinality="1"} ! prephytoene diphosphate relationship: has_output_compound UPa:UPC03427 ! prephytoene diphosphate relationship: part_of UPa:UER01030 {cardinality="1", direction="LR", order="1"} ! 15-cis-phytoene from geranylgeranyl diphosphate: step 1/1 relationship: part_of UPa:UER01030 ! 15-cis-phytoene from geranylgeranyl diphosphate: step 1/1 [Term] id: UPa:UCR02080 name: L-dopa = CO(2) + dopamine namespace: reaction xref: KEGG:R02080 "KEGG reaction" xref: METACYC:RXN66-221 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12275 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00355 {cardinality="1"} ! L-dopa relationship: has_input_compound UPa:UPC00355 ! L-dopa relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC03758 {cardinality="1"} ! dopamine relationship: has_output_compound UPa:UPC03758 ! dopamine relationship: part_of UPa:UER00734 {cardinality="1", direction="LR", order="1"} ! dopamine from L-tyrosine: step 2/2 relationship: part_of UPa:UER00734 ! dopamine from L-tyrosine: step 2/2 [Term] id: UPa:UCR02081 name: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH namespace: reaction xref: KEGG:R02081 "KEGG reaction" xref: METACYC:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14836 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00418 {cardinality="1"} ! (R)-mevalonate relationship: has_input_compound UPa:UPC00418 ! (R)-mevalonate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: part_of UPa:UER00367 {cardinality="1", direction="LR", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1 relationship: part_of UPa:UER00367 ! (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1 [Term] id: UPa:UCR02082 name: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH namespace: reaction xref: KEGG:R02082 "KEGG reaction" xref: METACYC:1.1.1.34-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15992 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00418 {cardinality="1"} ! (R)-mevalonate relationship: has_input_compound UPa:UPC00418 ! (R)-mevalonate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: part_of UPa:UER00103 ! (R)-mevalonate from acetyl-CoA: step 3/3 relationship: part_of UPa:UER00103 {cardinality="1", direction="RL", order="1"} ! (R)-mevalonate from acetyl-CoA: step 3/3 [Term] id: UPa:UCR02085 name: (S)-3-hydroxy-3-methylglutaryl-CoA = 3-methylglutaconyl-CoA + H(2)O namespace: reaction xref: KEGG:R02085 "KEGG reaction" xref: METACYC:METHYLGLUTACONYL-COA-HYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21539 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_input_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC03231 {cardinality="1"} ! 3-methylglutaconyl-CoA relationship: has_output_compound UPa:UPC03231 ! 3-methylglutaconyl-CoA relationship: part_of UPa:UER00862 {cardinality="1", direction="RL", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3 relationship: part_of UPa:UER00862 ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3 [Term] id: UPa:UCR02087 name: N-acetyl-D-glucosamine 6-phosphate = N-acetyl-D-mannosamine 6-phosphate namespace: reaction xref: KEGG:R02087 "KEGG reaction" xref: METACYC:NANE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25260 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00357 {cardinality="1"} ! N-acetyl-D-glucosamine 6-phosphate relationship: has_input_compound UPa:UPC00357 ! N-acetyl-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC04257 {cardinality="1"} ! N-acetyl-D-mannosamine 6-phosphate relationship: has_output_compound UPa:UPC04257 ! N-acetyl-D-mannosamine 6-phosphate relationship: part_of UPa:UER00682 ! D-fructose 6-phosphate from N-acetylneuraminate: step 3/5 relationship: part_of UPa:UER00682 {cardinality="1", direction="RL", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 3/5 [Term] id: UPa:UCR02100 name: H(2)O + dUTP = dUMP + diphosphate namespace: reaction xref: KEGG:R02100 "KEGG reaction" xref: METACYC:DUTP-PYROP-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10251 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00460 {cardinality="1"} ! dUTP relationship: has_input_compound UPa:UPC00460 ! dUTP relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00365 ! dUMP relationship: has_output_compound UPa:UPC00365 {cardinality="1"} ! dUMP relationship: part_of UPa:UER00666 ! dUMP from dCTP (dUTP route): step 2/2 relationship: part_of UPa:UER00666 {cardinality="1", direction="LR", order="1"} ! dUMP from dCTP (dUTP route): step 2/2 [Term] id: UPa:UCR02103 name: H(2)O + NAD(+) + xanthine = H(+) + NADH + urate namespace: reaction xref: KEGG:R02103 "KEGG reaction" xref: METACYC:RXN0-901 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16672 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00385 ! xanthine relationship: has_input_compound UPa:UPC00385 {cardinality="1"} ! xanthine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00366 ! urate relationship: has_output_compound UPa:UPC00366 {cardinality="1"} ! urate relationship: part_of UPa:UER00662 {cardinality="1", direction="LR", order="1"} ! urate from hypoxanthine: step 2/2 relationship: part_of UPa:UER00662 ! urate from hypoxanthine: step 2/2 [Term] id: UPa:UCR02106 name: H(2)O + O(2) + urate = 5-hydroxyisouric acid + H(2)O(2) namespace: reaction xref: KEGG:R02106 "KEGG reaction" xref: METACYC:URATE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21371 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00366 ! urate relationship: has_input_compound UPa:UPC00366 {cardinality="1"} ! urate relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC11821 {cardinality="1"} ! 5-hydroxyisouric acid relationship: has_output_compound UPa:UPC11821 ! 5-hydroxyisouric acid relationship: part_of UPa:UER00650 {cardinality="1", direction="LR", order="1"} ! (S)-allantoin from urate: step 1/3 relationship: part_of UPa:UER00650 ! (S)-allantoin from urate: step 1/3 [Term] id: UPa:UCR02133 name: H(2)O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+) namespace: reaction xref: KEGG:R02133 "KEGG reaction" xref: METACYC:THIAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17512 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00378 {cardinality="1"} ! thiamine relationship: has_input_compound UPa:UPC00378 ! thiamine relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01279 ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC01279 {cardinality="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC04294 {cardinality="1"} ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: has_output_compound UPa:UPC04294 ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: part_of UPa:UER00805 {cardinality="1", direction="LR", order="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole from thiamine: step 1/1 relationship: part_of UPa:UER00805 ! 4-amino-5-hydroxymethyl-2-methylpyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole from thiamine: step 1/1 [Term] id: UPa:UCR02134 name: ATP + thiamine = ADP + thiamine phosphate namespace: reaction xref: KEGG:R02134 "KEGG reaction" xref: METACYC:THIKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12015 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00378 {cardinality="1"} ! thiamine relationship: has_input_compound UPa:UPC00378 ! thiamine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC01081 ! thiamine phosphate relationship: has_output_compound UPa:UPC01081 {cardinality="1"} ! thiamine phosphate relationship: part_of UPa:UER00596 ! thiamine phosphate from thiamine: step 1/1 relationship: part_of UPa:UER00596 {cardinality="1", direction="LR", order="1"} ! thiamine phosphate from thiamine: step 1/1 [Term] id: UPa:UCR02139 name: H(2)O + barbiturate = 3-oxo-3-ureidopropanoic acid namespace: reaction xref: KEGG:R02139 "KEGG reaction" xref: METACYC:BARBITURASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18656 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00813 {cardinality="1"} ! barbiturate relationship: has_input_compound UPa:UPC00813 ! barbiturate relationship: has_output_compound UPa:UPC15607 ! 3-oxo-3-ureidopropanoic acid relationship: has_output_compound UPa:UPC15607 {cardinality="1"} ! 3-oxo-3-ureidopropanoic acid relationship: part_of UPa:UER00644 {cardinality="1", direction="LR", order="1"} ! malonate and urea from uracil: step 2/3 relationship: part_of UPa:UER00644 ! malonate and urea from uracil: step 2/3 [Term] id: UPa:UCR02142 name: XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine namespace: reaction xref: KEGG:R02142 "KEGG reaction" xref: METACYC:XANPRIBOSYLTRAN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10803 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00655 ! XMP relationship: has_input_compound UPa:UPC00655 {cardinality="1"} ! XMP relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00385 ! xanthine relationship: has_output_compound UPa:UPC00385 {cardinality="1"} ! xanthine relationship: part_of UPa:UER00658 {cardinality="1", direction="RL", order="1"} ! XMP from xanthine: step 1/1 relationship: part_of UPa:UER00658 ! XMP from xanthine: step 1/1 [Term] id: UPa:UCR02164 name: Quinone + succinate = Hydroquinone + fumarate namespace: reaction xref: KEGG:R02164 "KEGG reaction" xref: METACYC:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13716 "Rhea reaction" xref: RHEA:40526 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00042 ! succinate relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone relationship: has_input_compound UPa:UPC15602 ! Quinone relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone relationship: has_output_compound UPa:UPC15603 ! Hydroquinone relationship: part_of UPa:UER01006 ! fumarate from succinate (eukaryal route): step 1/1 relationship: part_of UPa:UER01006 {cardinality="1", direction="LR", order="1"} ! fumarate from succinate (eukaryal route): step 1/1 [Term] id: UPa:UCR02199 name: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate namespace: reaction xref: KEGG:R02199 "KEGG reaction" xref: METACYC:BRANCHED-CHAINAMINOTRANSFERILEU-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24804 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00407 {cardinality="1"} ! L-isoleucine relationship: has_input_compound UPa:UPC00407 ! L-isoleucine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00671 {cardinality="1"} ! (S)-3-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00671 ! (S)-3-methyl-2-oxopentanoate relationship: part_of UPa:UER00058 ! L-isoleucine from 2-oxobutanoate: step 4/4 relationship: part_of UPa:UER00058 {cardinality="1", direction="RL", order="1"} ! L-isoleucine from 2-oxobutanoate: step 4/4 [Term] id: UPa:UCR02236 name: 7,8-dihydrofolate + NADP(+) = H(+) + NADPH + folate namespace: reaction xref: KEGG:R02236 "KEGG reaction" xref: RHEA:31106 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00415 {cardinality="1"} ! 7,8-dihydrofolate relationship: has_input_compound UPa:UPC00415 ! 7,8-dihydrofolate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00504 {cardinality="1"} ! folate relationship: has_output_compound UPa:UPC00504 ! folate relationship: part_of UPa:UER00818 {cardinality="1", direction="RL", order="1"} ! 7,8-dihydrofolate from folate: step 1/1 relationship: part_of UPa:UER00818 ! 7,8-dihydrofolate from folate: step 1/1 [Term] id: UPa:UCR02237 name: 7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + phosphate namespace: reaction xref: KEGG:R02237 "KEGG reaction" xref: METACYC:DIHYDROFOLATESYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23587 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00921 ! 7,8-dihydropteroate relationship: has_input_compound UPa:UPC00921 {cardinality="1"} ! 7,8-dihydropteroate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00415 ! 7,8-dihydrofolate relationship: has_output_compound UPa:UPC00415 {cardinality="1"} ! 7,8-dihydrofolate relationship: part_of UPa:UER00157 {cardinality="1", direction="LR", order="1"} ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2 relationship: part_of UPa:UER00157 ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2 [Term] id: UPa:UCR02241 name: CoA + phosphatidate = 1-acyl-sn-glycerol 3-phosphate + acyl-CoA namespace: reaction xref: KEGG:R02241 "KEGG reaction" xref: METACYC:RXN-1623 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19712 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00416 ! phosphatidate relationship: has_input_compound UPa:UPC00416 {cardinality="1"} ! phosphatidate relationship: has_output_compound UPa:UPC00040 {cardinality="1"} ! acyl-CoA relationship: has_output_compound UPa:UPC00040 ! acyl-CoA relationship: has_output_compound UPa:UPC00681 {cardinality="1"} ! 1-acyl-sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00681 ! 1-acyl-sn-glycerol 3-phosphate relationship: part_of UPa:UER00613 {cardinality="1", direction="RL", order="1"} ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3 relationship: part_of UPa:UER00613 ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3 [Term] id: UPa:UCR02245 name: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP namespace: reaction xref: KEGG:R02245 "KEGG reaction" xref: METACYC:MEVALONATE-KINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17068 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00418 {cardinality="1"} ! (R)-mevalonate relationship: has_input_compound UPa:UPC00418 ! (R)-mevalonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC01107 ! (R)-5-phosphomevalonate relationship: has_output_compound UPa:UPC01107 {cardinality="1"} ! (R)-5-phosphomevalonate relationship: part_of UPa:UER00098 ! isopentenyl diphosphate from (R)-mevalonate: step 1/3 relationship: part_of UPa:UER00098 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from (R)-mevalonate: step 1/3 [Term] id: UPa:UCR02253 name: H(+) + NADPH + O(2) + trans-cinnamate = H(2)O + NADP(+) + trans-4-coumarate namespace: reaction xref: KEGG:R02253 "KEGG reaction" xref: METACYC:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10611 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00423 ! trans-cinnamate relationship: has_input_compound UPa:UPC00423 {cardinality="1"} ! trans-cinnamate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00811 {cardinality="1"} ! trans-4-coumarate relationship: has_output_compound UPa:UPC00811 ! trans-4-coumarate relationship: part_of UPa:UER00789 {cardinality="1", direction="LR", order="1"} ! trans-4-coumarate from trans-cinnamate: step 1/1 relationship: part_of UPa:UER00789 ! trans-4-coumarate from trans-cinnamate: step 1/1 [Term] id: UPa:UCR02262 name: L-fuculose 1-phosphate = L-lactaldehyde + glycerone phosphate namespace: reaction xref: KEGG:R02262 "KEGG reaction" xref: METACYC:FUCPALDOL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12936 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01099 {cardinality="1"} ! L-fuculose 1-phosphate relationship: has_input_compound UPa:UPC01099 ! L-fuculose 1-phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00424 {cardinality="1"} ! L-lactaldehyde relationship: has_output_compound UPa:UPC00424 ! L-lactaldehyde relationship: part_of UPa:UER00626 {cardinality="1", direction="LR", order="1"} ! L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3 relationship: part_of UPa:UER00626 ! L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3 [Term] id: UPa:UCR02263 name: L-rhamnulose 1-phosphate = L-lactaldehyde + glycerone phosphate namespace: reaction xref: KEGG:R02263 "KEGG reaction" xref: METACYC:RHAMNULPALDOL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19692 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01131 {cardinality="1"} ! L-rhamnulose 1-phosphate relationship: has_input_compound UPa:UPC01131 ! L-rhamnulose 1-phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00424 {cardinality="1"} ! L-lactaldehyde relationship: has_output_compound UPa:UPC00424 ! L-lactaldehyde relationship: part_of UPa:UER00603 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from L-rhamnose: step 3/3 relationship: part_of UPa:UER00603 ! glycerone phosphate from L-rhamnose: step 3/3 [Term] id: UPa:UCR02272 name: 5-aminolevulinate = (S)-4-amino-5-oxopentanoic acid namespace: reaction xref: KEGG:R02272 "KEGG reaction" xref: METACYC:GSAAMINOTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14268 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00430 {cardinality="1"} ! 5-aminolevulinate relationship: has_input_compound UPa:UPC00430 ! 5-aminolevulinate relationship: has_output_compound UPa:UPC03741 {cardinality="1"} ! (S)-4-amino-5-oxopentanoic acid relationship: has_output_compound UPa:UPC03741 ! (S)-4-amino-5-oxopentanoic acid relationship: part_of UPa:UER00317 {cardinality="1", direction="RL", order="1"} ! 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2 relationship: part_of UPa:UER00317 ! 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2 [Term] id: UPa:UCR02274 name: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate namespace: reaction xref: KEGG:R02274 "KEGG reaction" xref: METACYC:VAGL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10215 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00431 ! 5-aminopentanoate relationship: has_input_compound UPa:UPC00431 {cardinality="1"} ! 5-aminopentanoate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC03273 ! 5-oxopentanoate relationship: has_output_compound UPa:UPC03273 {cardinality="1"} ! 5-oxopentanoate relationship: part_of UPa:UER00845 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 5/6 relationship: part_of UPa:UER00845 ! glutarate from L-lysine: step 5/6 [Term] id: UPa:UCR02276 name: 5-acetamidopentanoate + H(2)O = 5-aminopentanoate + acetate namespace: reaction xref: KEGG:R02276 "KEGG reaction" xref: METACYC:AMVAL-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42515 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC03087 ! 5-acetamidopentanoate relationship: has_input_compound UPa:UPC03087 {cardinality="1"} ! 5-acetamidopentanoate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00431 ! 5-aminopentanoate relationship: has_output_compound UPa:UPC00431 {cardinality="1"} ! 5-aminopentanoate relationship: part_of UPa:UER00844 ! glutarate from L-lysine: step 4/6 relationship: part_of UPa:UER00844 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 4/6 [Term] id: UPa:UCR02278 name: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H(2)O namespace: reaction xref: KEGG:R02278 "KEGG reaction" xref: METACYC:4.2.1.43-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17204 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00684 ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_input_compound UPa:UPC00684 {cardinality="1"} ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00433 ! 2,5-dioxopentanoate relationship: has_output_compound UPa:UPC00433 {cardinality="1"} ! 2,5-dioxopentanoate relationship: part_of UPa:UER00572 {cardinality="1", direction="LR", order="1"} ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate: step 1/2 relationship: part_of UPa:UER00572 ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate: step 1/2 [Term] id: UPa:UCR02279 name: 5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + CO(2) + H(2)O namespace: reaction xref: KEGG:R02279 "KEGG reaction" xref: METACYC:4.2.1.41-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24611 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00679 ! 5-dehydro-4-deoxy-D-glucarate relationship: has_input_compound UPa:UPC00679 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucarate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00433 ! 2,5-dioxopentanoate relationship: has_output_compound UPa:UPC00433 {cardinality="1"} ! 2,5-dioxopentanoate relationship: part_of UPa:UER00628 {cardinality="1", direction="LR", order="1"} ! 2,5-dioxopentanoate from D-glucarate: step 2/2 relationship: part_of UPa:UER00628 ! 2,5-dioxopentanoate from D-glucarate: step 2/2 [Term] id: UPa:UCR02282 name: L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate namespace: reaction xref: KEGG:R02282 "KEGG reaction" xref: METACYC:GLUTAMATE-N-ACETYLTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15352 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00437 ! N(2)-acetyl-L-ornithine relationship: has_input_compound UPa:UPC00437 {cardinality="1"} ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00624 ! N-acetyl-L-glutamate relationship: has_output_compound UPa:UPC00624 {cardinality="1"} ! N-acetyl-L-glutamate relationship: part_of UPa:UER00111 {cardinality="1", direction="LR", order="1"} ! L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1 relationship: part_of UPa:UER00111 ! L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1 [Term] id: UPa:UCR02283 name: 2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde namespace: reaction xref: KEGG:R02283 "KEGG reaction" xref: METACYC:ACETYLORNTRANSAM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18052 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00437 ! N(2)-acetyl-L-ornithine relationship: has_input_compound UPa:UPC00437 {cardinality="1"} ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC01250 {cardinality="1"} ! N-acetyl-L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC01250 ! N-acetyl-L-glutamate 5-semialdehyde relationship: part_of UPa:UER00109 ! N(2)-acetyl-L-ornithine from L-glutamate: step 4/4 relationship: part_of UPa:UER00109 {cardinality="1", direction="RL", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate: step 4/4 [Term] id: UPa:UCR02285 name: H(2)O + N-formimidoyl-L-glutamate = L-glutamate + formamide namespace: reaction xref: KEGG:R02285 "KEGG reaction" xref: METACYC:FORMIMINOGLUTAMASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22495 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate relationship: has_input_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00488 {cardinality="1"} ! formamide relationship: has_output_compound UPa:UPC00488 ! formamide relationship: part_of UPa:UER00552 {cardinality="1", direction="LR", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1 relationship: part_of UPa:UER00552 ! L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1 [Term] id: UPa:UCR02286 name: H(2)O + N-formimidoyl-L-glutamate = N-formyl-L-glutamate + NH(3) namespace: reaction xref: KEGG:R02286 "KEGG reaction" xref: METACYC:FORMIMINOGLUTAMATE-DEIMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22835 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate relationship: has_input_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC01045 {cardinality="1"} ! N-formyl-L-glutamate relationship: has_output_compound UPa:UPC01045 ! N-formyl-L-glutamate relationship: part_of UPa:UER00553 {cardinality="1", direction="LR", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route): step 1/2 relationship: part_of UPa:UER00553 ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route): step 1/2 [Term] id: UPa:UCR02287 name: 5-formiminotetrahydrofolate + L-glutamate = 5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate namespace: reaction xref: KEGG:R02287 "KEGG reaction" xref: METACYC:GLUTAMATE-FORMIMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15100 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00664 ! 5-formiminotetrahydrofolate relationship: has_input_compound UPa:UPC00664 {cardinality="1"} ! 5-formiminotetrahydrofolate relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate relationship: part_of UPa:UER00555 {cardinality="1", direction="RL", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1 relationship: part_of UPa:UER00555 ! L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1 [Term] id: UPa:UCR02288 name: 4-imidazolone-5-propanoate + H(2)O = N-formimidoyl-L-glutamate namespace: reaction xref: KEGG:R02288 "KEGG reaction" xref: METACYC:IMIDAZOLONEPROPIONASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23663 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC03680 {cardinality="1"} ! 4-imidazolone-5-propanoate relationship: has_input_compound UPa:UPC03680 ! 4-imidazolone-5-propanoate relationship: has_output_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate relationship: part_of UPa:UER00551 ! N-formimidoyl-L-glutamate from L-histidine: step 3/3 relationship: part_of UPa:UER00551 {cardinality="1", direction="LR", order="1"} ! N-formimidoyl-L-glutamate from L-histidine: step 3/3 [Term] id: UPa:UCR02291 name: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH namespace: reaction xref: KEGG:R02291 "KEGG reaction" xref: METACYC:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24287 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03082 {cardinality="1"} ! 4-phospho-L-aspartate relationship: has_output_compound UPa:UPC03082 ! 4-phospho-L-aspartate relationship: part_of UPa:UER00016 ! (S)-tetrahydrodipicolinate from L-aspartate: step 2/4 relationship: part_of UPa:UER00016 {cardinality="1", direction="RL", order="1"} ! (S)-tetrahydrodipicolinate from L-aspartate: step 2/4 relationship: part_of UPa:UER00463 {cardinality="1", direction="RL", order="1"} ! L-threonine from L-aspartate: step 2/5 relationship: part_of UPa:UER00463 ! L-threonine from L-aspartate: step 2/5 relationship: part_of UPa:UER00464 {cardinality="1", direction="RL", order="1"} ! L-homoserine from L-aspartate: step 2/3 relationship: part_of UPa:UER00464 ! L-homoserine from L-aspartate: step 2/3 [Term] id: UPa:UCR02305 name: farnesyl diphosphate = diphosphate + pentalenene namespace: reaction xref: KEGG:R02305 "KEGG reaction" xref: METACYC:PENTALENENE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18084 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC01841 {cardinality="1"} ! pentalenene relationship: has_output_compound UPa:UPC01841 ! pentalenene relationship: part_of UPa:UER00581 {cardinality="1", direction="LR", order="1"} ! pentalenene from farnesyl diphosphate: step 1/1 relationship: part_of UPa:UER00581 ! pentalenene from farnesyl diphosphate: step 1/1 [Term] id: UPa:UCR02307 name: farnesyl diphosphate = aristolochene + diphosphate namespace: reaction xref: KEGG:R02307 "KEGG reaction" xref: METACYC:ARISTOLOCHENE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19828 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC02004 ! aristolochene relationship: has_output_compound UPa:UPC02004 {cardinality="1"} ! aristolochene relationship: part_of UPa:UER00582 ! aristolochene from farnesyl diphosphate: step 1/1 relationship: part_of UPa:UER00582 {cardinality="1", direction="LR", order="1"} ! aristolochene from farnesyl diphosphate: step 1/1 [Term] id: UPa:UCR02313 name: H(2)O + NAD(+) + saccharopine = H(+) + L-2-aminoadipate 6-semialdahyde + L-glutamate + NADH namespace: reaction xref: KEGG:R02313 "KEGG reaction" xref: METACYC:1.5.1.9-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24523 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00449 ! saccharopine relationship: has_input_compound UPa:UPC00449 {cardinality="1"} ! saccharopine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde relationship: part_of UPa:UER00836 ! glutaryl-CoA from L-lysine: step 2/6 relationship: part_of UPa:UER00836 {cardinality="1", direction="LR", order="1"} ! glutaryl-CoA from L-lysine: step 2/6 [Term] id: UPa:UCR02315 name: H(2)O + NADP(+) + saccharopine = H(+) + L-2-aminoadipate 6-semialdahyde + L-glutamate + NADPH namespace: reaction xref: KEGG:R02315 "KEGG reaction" xref: METACYC:RXN3O-127 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10023 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00449 ! saccharopine relationship: has_input_compound UPa:UPC00449 {cardinality="1"} ! saccharopine relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde relationship: part_of UPa:UER00033 ! L-lysine from L-alpha-aminoadipate (fungal route): step 2/3 relationship: part_of UPa:UER00033 {cardinality="1", direction="RL", order="1"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 2/3 [Term] id: UPa:UCR02325 name: H(2)O + dCTP = NH(3) + dUTP namespace: reaction xref: KEGG:R02325 "KEGG reaction" xref: METACYC:DCTP-DEAM-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22683 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00458 {cardinality="1"} ! dCTP relationship: has_input_compound UPa:UPC00458 ! dCTP relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00460 {cardinality="1"} ! dUTP relationship: has_output_compound UPa:UPC00460 ! dUTP relationship: part_of UPa:UER00665 {cardinality="1", direction="LR", order="1"} ! dUMP from dCTP (dUTP route): step 1/2 relationship: part_of UPa:UER00665 ! dUMP from dCTP (dUTP route): step 1/2 [Term] id: UPa:UCR02340 name: indoleglycerol phosphate = D-glyceraldehyde 3-phosphate + indole namespace: reaction xref: KEGG:R02340 "KEGG reaction" xref: METACYC:RXN0-2381 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14084 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03506 ! indoleglycerol phosphate relationship: has_input_compound UPa:UPC03506 {cardinality="1"} ! indoleglycerol phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00463 {cardinality="1"} ! indole relationship: has_output_compound UPa:UPC00463 ! indole relationship: part_of UPa:UER00044 ! L-tryptophan from chorismate: step 5/5 relationship: part_of UPa:UER00044 {cardinality="1", direction="LR", order="1"} ! L-tryptophan from chorismate: step 5/5 relationship: part_of UPa:UER00847 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 1/5 relationship: part_of UPa:UER00847 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 1/5 [Term] id: UPa:UCR02362 name: n H(2)O + pectin = n methanol + pectate namespace: reaction xref: KEGG:R02362 "KEGG reaction" xref: METACYC:PECTINESTERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00714 {cardinality="1"} ! pectin relationship: has_input_compound UPa:UPC00714 ! pectin relationship: has_output_compound UPa:UPC00132 ! methanol relationship: has_output_compound UPa:UPC00132 {cardinality="1"} ! methanol relationship: has_output_compound UPa:UPC00470 {cardinality="1"} ! pectate relationship: has_output_compound UPa:UPC00470 ! pectate relationship: part_of UPa:UER00823 ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5 relationship: part_of UPa:UER00823 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5 [Term] id: UPa:UCR02401 name: 5-oxopentanoate + H(2)O + NAD(+) = H(+) + NADH + glutarate namespace: reaction xref: KEGG:R02401 "KEGG reaction" xref: METACYC:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12067 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC03273 ! 5-oxopentanoate relationship: has_input_compound UPa:UPC03273 {cardinality="1"} ! 5-oxopentanoate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00489 ! glutarate relationship: has_output_compound UPa:UPC00489 {cardinality="1"} ! glutarate relationship: part_of UPa:UER00846 ! glutarate from L-lysine: step 6/6 relationship: part_of UPa:UER00846 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 6/6 [Term] id: UPa:UCR02412 name: ATP + shikimate = 3-phosphoshikimate + ADP namespace: reaction xref: KEGG:R02412 "KEGG reaction" xref: METACYC:SHIKIMATE-KINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13124 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00493 ! shikimate relationship: has_input_compound UPa:UPC00493 {cardinality="1"} ! shikimate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC03175 {cardinality="1"} ! 3-phosphoshikimate relationship: has_output_compound UPa:UPC03175 ! 3-phosphoshikimate relationship: part_of UPa:UER00088 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7 relationship: part_of UPa:UER00088 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7 [Term] id: UPa:UCR02413 name: NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH namespace: reaction xref: KEGG:R02413 "KEGG reaction" xref: METACYC:SHIKIMATE-5-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17740 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00493 ! shikimate relationship: has_input_compound UPa:UPC00493 {cardinality="1"} ! shikimate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC02637 {cardinality="1"} ! 3-dehydroshikimate relationship: has_output_compound UPa:UPC02637 ! 3-dehydroshikimate relationship: part_of UPa:UER00087 {cardinality="1", direction="RL", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7 relationship: part_of UPa:UER00087 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7 [Term] id: UPa:UCR02422 name: H(2)O + allantoate = (S)-ureidoglycolate + urea namespace: reaction xref: KEGG:R02422 "KEGG reaction" xref: METACYC:ALLANTOICASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11019 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00499 {cardinality="1"} ! allantoate relationship: has_input_compound UPa:UPC00499 ! allantoate relationship: has_output_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_output_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: part_of UPa:UER00654 {cardinality="1", direction="LR", order="1"} ! (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1 relationship: part_of UPa:UER00654 ! (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1 [Term] id: UPa:UCR02423 name: H(2)O + allantoate = 2-ureidoglycine + CO(2) + NH(3) namespace: reaction xref: KEGG:R02423 "KEGG reaction" xref: METACYC:ALLANTOATE-DEIMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13596 "Rhea reaction" xref: RHEA:27488 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00499 ! allantoate relationship: has_input_compound UPa:UPC00499 {cardinality="1"} ! allantoate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC02091 {cardinality="1"} ! 2-ureidoglycine relationship: has_output_compound UPa:UPC02091 ! 2-ureidoglycine relationship: part_of UPa:UER00655 {cardinality="1", direction="LR", order="1"} ! (S)-ureidoglycolate from allantoate (amidohydrolase route): step 1/1 relationship: part_of UPa:UER00655 ! (S)-ureidoglycolate from allantoate (amidohydrolase route): step 1/1 [Term] id: UPa:UCR02425 name: (S)-allantoin + H(2)O = allantoate namespace: reaction xref: KEGG:R02425 "KEGG reaction" xref: METACYC:ALLANTOINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17032 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02350 {cardinality="1"} ! (S)-allantoin relationship: has_input_compound UPa:UPC02350 ! (S)-allantoin relationship: has_output_compound UPa:UPC00499 ! allantoate relationship: has_output_compound UPa:UPC00499 {cardinality="1"} ! allantoate relationship: part_of UPa:UER00653 ! allantoate from (S)-allantoin: step 1/1 relationship: part_of UPa:UER00653 {cardinality="1", direction="LR", order="1"} ! allantoate from (S)-allantoin: step 1/1 [Term] id: UPa:UCR02426 name: CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H(2)O namespace: reaction xref: KEGG:R02426 "KEGG reaction" xref: METACYC:CDP-GLUCOSE-46-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17156 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00501 ! CDP-glucose relationship: has_input_compound UPa:UPC00501 {cardinality="1"} ! CDP-glucose relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01219 ! CDP-4-dehydro-6-deoxy-D-glucose relationship: has_output_compound UPa:UPC01219 {cardinality="1"} ! CDP-4-dehydro-6-deoxy-D-glucose relationship: part_of UPa:UER00512 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 2/5 relationship: part_of UPa:UER00512 {cardinality="1", direction="LR", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 2/5 [Term] id: UPa:UCR02437 name: L-rhamnose = L-rhamnulose namespace: reaction xref: KEGG:R02437 "KEGG reaction" xref: METACYC:RHAMNISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23163 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00507 {cardinality="1"} ! L-rhamnose relationship: has_input_compound UPa:UPC00507 ! L-rhamnose relationship: has_output_compound UPa:UPC00861 ! L-rhamnulose relationship: has_output_compound UPa:UPC00861 {cardinality="1"} ! L-rhamnulose relationship: part_of UPa:UER00601 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from L-rhamnose: step 1/3 relationship: part_of UPa:UER00601 ! glycerone phosphate from L-rhamnose: step 1/3 [Term] id: UPa:UCR02439 name: ATP + L-ribulose = ADP + L-ribulose 5-phosphate namespace: reaction xref: KEGG:R02439 "KEGG reaction" xref: METACYC:RXN0-5116 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22075 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00508 {cardinality="1"} ! L-ribulose relationship: has_input_compound UPa:UPC00508 ! L-ribulose relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC01101 ! L-ribulose 5-phosphate relationship: has_output_compound UPa:UPC01101 {cardinality="1"} ! L-ribulose 5-phosphate relationship: part_of UPa:UER00566 ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3 relationship: part_of UPa:UER00566 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3 [Term] id: UPa:UCR02466 name: 3-sulfino-L-alanine = CO(2) + hypotaurine namespace: reaction xref: KEGG:R02466 "KEGG reaction" xref: METACYC:SULFINOALANINE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16880 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00606 {cardinality="1"} ! 3-sulfino-L-alanine relationship: has_input_compound UPa:UPC00606 ! 3-sulfino-L-alanine relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00519 ! hypotaurine relationship: has_output_compound UPa:UPC00519 {cardinality="1"} ! hypotaurine relationship: part_of UPa:UER00538 {cardinality="1", direction="LR", order="1"} ! hypotaurine from L-cysteine: step 2/2 relationship: part_of UPa:UER00538 ! hypotaurine from L-cysteine: step 2/2 [Term] id: UPa:UCR02467 name: 2-aminoethanethiol + O(2) = hypotaurine namespace: reaction xref: KEGG:R02467 "KEGG reaction" xref: METACYC:CYSTEAMINE-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14412 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC01678 {cardinality="1"} ! 2-aminoethanethiol relationship: has_input_compound UPa:UPC01678 ! 2-aminoethanethiol relationship: has_output_compound UPa:UPC00519 ! hypotaurine relationship: has_output_compound UPa:UPC00519 {cardinality="1"} ! hypotaurine relationship: part_of UPa:UER00536 {cardinality="1", direction="LR", order="1"} ! hypotaurine from 2-aminoethanethiol: step 1/1 relationship: part_of UPa:UER00536 ! hypotaurine from 2-aminoethanethiol: step 1/1 [Term] id: UPa:UCR02472 name: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH namespace: reaction xref: KEGG:R02472 "KEGG reaction" xref: METACYC:2-DEHYDROPANTOATE-REDUCT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16236 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00522 ! (R)-pantoate relationship: has_input_compound UPa:UPC00522 {cardinality="1"} ! (R)-pantoate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00966 {cardinality="1"} ! 2-dehydropantoate relationship: has_output_compound UPa:UPC00966 ! 2-dehydropantoate relationship: part_of UPa:UER00004 ! (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2 relationship: part_of UPa:UER00004 {cardinality="1", direction="RL", order="1"} ! (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2 [Term] id: UPa:UCR02473 name: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate namespace: reaction xref: KEGG:R02473 "KEGG reaction" xref: METACYC:PANTOATE-BETA-ALANINE-LIG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10915 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00099 ! beta-alanine relationship: has_input_compound UPa:UPC00099 {cardinality="1"} ! beta-alanine relationship: has_input_compound UPa:UPC00522 {cardinality="1"} ! (R)-pantoate relationship: has_input_compound UPa:UPC00522 ! (R)-pantoate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00864 ! (R)-pantothenate relationship: has_output_compound UPa:UPC00864 {cardinality="1"} ! (R)-pantothenate relationship: part_of UPa:UER00005 ! (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1 relationship: part_of UPa:UER00005 {cardinality="1", direction="LR", order="1"} ! (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1 [Term] id: UPa:UCR02493 name: ATP + pyridoxamine = ADP + pyridoxamine 5'-phosphate namespace: reaction xref: KEGG:R02493 "KEGG reaction" xref: METACYC:PYRAMKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25107 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00534 ! pyridoxamine relationship: has_input_compound UPa:UPC00534 {cardinality="1"} ! pyridoxamine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00647 ! pyridoxamine 5'-phosphate relationship: has_output_compound UPa:UPC00647 {cardinality="1"} ! pyridoxamine 5'-phosphate relationship: part_of UPa:UER00299 {cardinality="1", direction="LR", order="1"} ! pyridoxamine 5'-phosphate from pyridoxamine: step 1/1 relationship: part_of UPa:UER00299 ! pyridoxamine 5'-phosphate from pyridoxamine: step 1/1 [Term] id: UPa:UCR02494 name: phosphate + pyridoxamine = H(2)O + pyridoxamine 5'-phosphate namespace: reaction xref: KEGG:R02494 "KEGG reaction" xref: RHEA:25138 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00534 ! pyridoxamine relationship: has_input_compound UPa:UPC00534 {cardinality="1"} ! pyridoxamine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00647 ! pyridoxamine 5'-phosphate relationship: has_output_compound UPa:UPC00647 {cardinality="1"} ! pyridoxamine 5'-phosphate relationship: part_of UPa:UER00302 ! pyridoxamine from pyridoxamine 5'-phosphate: step 1/1 relationship: part_of UPa:UER00302 {cardinality="1", direction="RL", order="1"} ! pyridoxamine from pyridoxamine 5'-phosphate: step 1/1 [Term] id: UPa:UCR02519 name: O(2) + homogentisate = 4-maleylacetoacetate namespace: reaction xref: KEGG:R02519 "KEGG reaction" xref: METACYC:HOMOGENTISATE-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15452 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00544 ! homogentisate relationship: has_input_compound UPa:UPC00544 {cardinality="1"} ! homogentisate relationship: has_output_compound UPa:UPC01036 {cardinality="1"} ! 4-maleylacetoacetate relationship: has_output_compound UPa:UPC01036 ! 4-maleylacetoacetate relationship: part_of UPa:UER00339 ! acetoacetate and fumarate from L-phenylalanine: step 4/6 relationship: part_of UPa:UER00339 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 4/6 [Term] id: UPa:UCR02521 name: (4-hydroxyphenyl)pyruvate + O(2) = CO(2) + homogentisate namespace: reaction xref: KEGG:R02521 "KEGG reaction" xref: METACYC:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16192 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate relationship: has_input_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00544 ! homogentisate relationship: has_output_compound UPa:UPC00544 {cardinality="1"} ! homogentisate relationship: part_of UPa:UER00362 ! acetoacetate and fumarate from L-phenylalanine: step 3/6 relationship: part_of UPa:UER00362 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 3/6 [Term] id: UPa:UCR02522 name: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H(2)O namespace: reaction xref: KEGG:R02522 "KEGG reaction" xref: METACYC:L-ARABINONATE-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20971 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00545 ! L-arabinonate relationship: has_input_compound UPa:UPC00545 {cardinality="1"} ! L-arabinonate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00684 ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_output_compound UPa:UPC00684 {cardinality="1"} ! 2-dehydro-3-deoxy-L-arabinonate relationship: part_of UPa:UER00570 ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 3/3 relationship: part_of UPa:UER00570 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 3/3 [Term] id: UPa:UCR02526 name: H(2)O + L-arabinono-1,4-lactone = L-arabinonate namespace: reaction xref: KEGG:R02526 "KEGG reaction" xref: METACYC:L-ARABINONOLACTONASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16220 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01114 {cardinality="1"} ! L-arabinono-1,4-lactone relationship: has_input_compound UPa:UPC01114 ! L-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC00545 {cardinality="1"} ! L-arabinonate relationship: has_output_compound UPa:UPC00545 ! L-arabinonate relationship: part_of UPa:UER00569 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 2/3 relationship: part_of UPa:UER00569 ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 2/3 [Term] id: UPa:UCR02530 name: (R)-S-lactoylglutathione = glutathione + methylglyoxal namespace: reaction xref: KEGG:R02530 "KEGG reaction" xref: METACYC:GLYOXI-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19072 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03451 {cardinality="1"} ! (R)-S-lactoylglutathione relationship: has_input_compound UPa:UPC03451 ! (R)-S-lactoylglutathione relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione relationship: has_output_compound UPa:UPC00051 ! glutathione relationship: has_output_compound UPa:UPC00546 {cardinality="1"} ! methylglyoxal relationship: has_output_compound UPa:UPC00546 ! methylglyoxal relationship: part_of UPa:UER00675 ! (R)-lactate from methylglyoxal: step 1/2 relationship: part_of UPa:UER00675 {cardinality="1", direction="RL", order="1"} ! (R)-lactate from methylglyoxal: step 1/2 [Term] id: UPa:UCR02533 name: (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R02533 "KEGG reaction" xref: METACYC:RXN66-241 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25272 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00547 {cardinality="1"} ! (R)-noradrenaline relationship: has_input_compound UPa:UPC00547 ! (R)-noradrenaline relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00788 {cardinality="1"} ! (R)-adrenaline relationship: has_output_compound UPa:UPC00788 ! (R)-adrenaline relationship: part_of UPa:UER00736 ! (R)-adrenaline from (R)-noradrenaline: step 1/1 relationship: part_of UPa:UER00736 {cardinality="1", direction="LR", order="1"} ! (R)-adrenaline from (R)-noradrenaline: step 1/1 [Term] id: UPa:UCR02535 name: L-ascorbate + O(2) + dopamine = (R)-noradrenaline + H(2)O + L-dehydroascorbate namespace: reaction xref: KEGG:R02535 "KEGG reaction" xref: METACYC:DOPAMINE-BETA-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19120 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_input_compound UPa:UPC00072 ! L-ascorbate relationship: has_input_compound UPa:UPC03758 ! dopamine relationship: has_input_compound UPa:UPC03758 {cardinality="1"} ! dopamine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00547 ! (R)-noradrenaline relationship: has_output_compound UPa:UPC00547 {cardinality="1"} ! (R)-noradrenaline relationship: has_output_compound UPa:UPC05422 ! L-dehydroascorbate relationship: has_output_compound UPa:UPC05422 {cardinality="1"} ! L-dehydroascorbate relationship: part_of UPa:UER00735 {cardinality="1", direction="LR", order="1"} ! (R)-noradrenaline from dopamine: step 1/1 relationship: part_of UPa:UER00735 ! (R)-noradrenaline from dopamine: step 1/1 [Term] id: UPa:UCR02536 name: H(2)O + NAD(+) + phenylacetaldehyde = H(+) + NADH + phenylacetate namespace: reaction xref: KEGG:R02536 "KEGG reaction" xref: METACYC:PHENDEHYD-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21395 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00601 ! phenylacetaldehyde relationship: has_input_compound UPa:UPC00601 {cardinality="1"} ! phenylacetaldehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC07086 {cardinality="1"} ! phenylacetate relationship: has_output_compound UPa:UPC07086 ! phenylacetate relationship: part_of UPa:UER00724 {cardinality="1", direction="LR", order="1"} ! phenylacetate from L-phenylalanine: step 3/3 relationship: part_of UPa:UER00724 ! phenylacetate from L-phenylalanine: step 3/3 [Term] id: UPa:UCR02545 name: NAD(+) + meso-tartrate = 2-hydroxy-3-oxosuccinate + H(+) + NADH namespace: reaction xref: KEGG:R02545 "KEGG reaction" xref: METACYC:RXN-8643 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16460 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00552 ! meso-tartrate relationship: has_input_compound UPa:UPC00552 {cardinality="1"} ! meso-tartrate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate relationship: part_of UPa:UER00801 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-3-oxosuccinate from meso-tartrate: step 1/1 relationship: part_of UPa:UER00801 ! 2-hydroxy-3-oxosuccinate from meso-tartrate: step 1/1 [Term] id: UPa:UCR02549 name: 4-aminobutanal + H(2)O + NAD(+) = 4-aminobutanoate + H(+) + NADH namespace: reaction xref: KEGG:R02549 "KEGG reaction" xref: METACYC:AMINOBUTDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19108 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00555 ! 4-aminobutanal relationship: has_input_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00334 {cardinality="1"} ! 4-aminobutanoate relationship: has_output_compound UPa:UPC00334 ! 4-aminobutanoate relationship: part_of UPa:UER00292 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanoate from 4-aminobutanal: step 1/1 relationship: part_of UPa:UER00292 ! 4-aminobutanoate from 4-aminobutanal: step 1/1 [Term] id: UPa:UCR02553 name: NAD(+) + cyclopentanol = H(+) + NADH + cyclopentanone namespace: reaction xref: KEGG:R02553 "KEGG reaction" xref: METACYC:CYCLOPENTANOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11731 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC02020 {cardinality="1"} ! cyclopentanol relationship: has_input_compound UPa:UPC02020 ! cyclopentanol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00557 {cardinality="1"} ! cyclopentanone relationship: has_output_compound UPa:UPC00557 ! cyclopentanone relationship: part_of UPa:UER00749 {cardinality="1", direction="LR", order="1"} ! 5-valerolactone from cyclopentanol: step 1/2 relationship: part_of UPa:UER00749 ! 5-valerolactone from cyclopentanol: step 1/2 [Term] id: UPa:UCR02554 name: H(+) + NADPH + O(2) + cyclopentanone = 5-valerolactone + H(2)O + NADP(+) namespace: reaction xref: KEGG:R02554 "KEGG reaction" xref: METACYC:CYCLOPENTANONE-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15740 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00557 {cardinality="1"} ! cyclopentanone relationship: has_input_compound UPa:UPC00557 ! cyclopentanone relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC02240 {cardinality="1"} ! 5-valerolactone relationship: has_output_compound UPa:UPC02240 ! 5-valerolactone relationship: part_of UPa:UER00750 {cardinality="1", direction="LR", order="1"} ! 5-valerolactone from cyclopentanol: step 2/2 relationship: part_of UPa:UER00750 ! 5-valerolactone from cyclopentanol: step 2/2 [Term] id: UPa:UCR02565 name: H(2)O + NAD(+) + betaine aldehyde = 2 H(+) + NADH + betaine namespace: reaction xref: KEGG:R02565 "KEGG reaction" xref: METACYC:BADH-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15308 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00576 ! betaine aldehyde relationship: has_input_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00719 ! betaine relationship: has_output_compound UPa:UPC00719 {cardinality="1"} ! betaine relationship: part_of UPa:UER00386 {cardinality="1", direction="LR", order="1"} ! betaine from betaine aldehyde: step 1/1 relationship: part_of UPa:UER00386 ! betaine from betaine aldehyde: step 1/1 [Term] id: UPa:UCR02571 name: Enzyme N6-(dihydrolipoyl)lysine + glutaryl-CoA = CoA + S(8)-glutaryldihydrolipoamide namespace: reaction xref: KEGG:R02571 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00527 {cardinality="1"} ! glutaryl-CoA relationship: has_input_compound UPa:UPC00527 ! glutaryl-CoA relationship: has_input_compound UPa:UPC15973 {cardinality="1"} ! Enzyme N6-(dihydrolipoyl)lysine relationship: has_input_compound UPa:UPC15973 ! Enzyme N6-(dihydrolipoyl)lysine relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC06157 ! S(8)-glutaryldihydrolipoamide relationship: has_output_compound UPa:UPC06157 {cardinality="1"} ! S(8)-glutaryldihydrolipoamide relationship: part_of UPa:UER00840 ! glutaryl-CoA from L-lysine: step 6/6 relationship: part_of UPa:UER00840 {cardinality="1", direction="RL", order="1"} ! glutaryl-CoA from L-lysine: step 6/6 [Term] id: UPa:UCR02601 name: 2-hydroxy-2,4-pentadienoate + H(2)O = 4-hydroxy-2-oxopentanoate namespace: reaction xref: KEGG:R02601 "KEGG reaction" xref: METACYC:2-OXOPENT-4-ENOATE-HYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22583 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate relationship: has_input_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC03589 ! 4-hydroxy-2-oxopentanoate relationship: has_output_compound UPa:UPC03589 {cardinality="1"} ! 4-hydroxy-2-oxopentanoate relationship: part_of UPa:UER00796 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 3/4 relationship: part_of UPa:UER00796 ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 3/4 relationship: part_of UPa:UER00906 ! acetaldehyde and pyruvate from p-cumate: step 6/7 relationship: part_of UPa:UER00906 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 6/7 [Term] id: UPa:UCR02603 name: 2-hydroxy-2,4-pentadienoate + succinate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H(2)O namespace: reaction xref: KEGG:R02603 "KEGG reaction" xref: METACYC:MHPCHYDROL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24792 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00042 ! succinate relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_input_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate relationship: has_input_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC04479 {cardinality="1"} ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate relationship: has_output_compound UPa:UPC04479 ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate relationship: part_of UPa:UER00795 ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 2/4 relationship: part_of UPa:UER00795 {cardinality="1", direction="RL", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 2/4 [Term] id: UPa:UCR02606 name: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(2)O = 2-hydroxy-2,4-pentadienoate + benzoate namespace: reaction xref: KEGG:R02606 "KEGG reaction" xref: METACYC:3.7.1.8-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17164 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01273 ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate relationship: has_input_compound UPa:UPC01273 {cardinality="1"} ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate relationship: has_output_compound UPa:UPC00180 ! benzoate relationship: has_output_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: has_output_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: part_of UPa:UER00253 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 4/4 relationship: part_of UPa:UER00253 ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 4/4 [Term] id: UPa:UCR02613 name: 2-phenylethylamine + H(2)O + O(2) = H(2)O(2) + NH(3) + phenylacetaldehyde namespace: reaction xref: KEGG:R02613 "KEGG reaction" xref: METACYC:AMINEPHEN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25268 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC05332 {cardinality="1"} ! 2-phenylethylamine relationship: has_input_compound UPa:UPC05332 ! 2-phenylethylamine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00601 {cardinality="1"} ! phenylacetaldehyde relationship: has_output_compound UPa:UPC00601 ! phenylacetaldehyde relationship: part_of UPa:UER00723 ! phenylacetate from L-phenylalanine: step 2/3 relationship: part_of UPa:UER00723 {cardinality="1", direction="LR", order="1"} ! phenylacetate from L-phenylalanine: step 2/3 [Term] id: UPa:UCR02649 name: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate namespace: reaction xref: KEGG:R02649 "KEGG reaction" xref: METACYC:ACETYLGLUTKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14632 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00624 {cardinality="1"} ! N-acetyl-L-glutamate relationship: has_input_compound UPa:UPC00624 ! N-acetyl-L-glutamate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04133 ! N-acetyl-L-glutamyl 5-phosphate relationship: has_output_compound UPa:UPC04133 {cardinality="1"} ! N-acetyl-L-glutamyl 5-phosphate relationship: part_of UPa:UER00107 ! N(2)-acetyl-L-ornithine from L-glutamate: step 2/4 relationship: part_of UPa:UER00107 {cardinality="1", direction="LR", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate: step 2/4 [Term] id: UPa:UCR02664 name: 2-phospho-D-glycerate + ATP = 2,3-bisphospho-D-glycerate + ADP namespace: reaction xref: KEGG:R02664 "KEGG reaction" xref: RHEA:42411 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00631 {cardinality="1"} ! 2-phospho-D-glycerate relationship: has_input_compound UPa:UPC00631 ! 2-phospho-D-glycerate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC01159 {cardinality="1"} ! 2,3-bisphospho-D-glycerate relationship: has_output_compound UPa:UPC01159 ! 2,3-bisphospho-D-glycerate relationship: part_of UPa:UER00609 {cardinality="1", direction="LR", order="1"} ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 1/2 relationship: part_of UPa:UER00609 ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 1/2 [Term] id: UPa:UCR02665 name: 3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde namespace: reaction xref: KEGG:R02665 "KEGG reaction" xref: METACYC:1.13.11.6-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17956 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00632 {cardinality="1"} ! 3-hydroxyanthranilate relationship: has_input_compound UPa:UPC00632 ! 3-hydroxyanthranilate relationship: has_output_compound UPa:UPC04409 ! 2-amino-3-carboxymuconate semialdehyde relationship: has_output_compound UPa:UPC04409 {cardinality="1"} ! 2-amino-3-carboxymuconate semialdehyde relationship: part_of UPa:UER00330 ! quinolinate from L-kynurenine: step 3/3 relationship: part_of UPa:UER00330 {cardinality="1", direction="LR", order="1"} ! quinolinate from L-kynurenine: step 3/3 [Term] id: UPa:UCR02668 name: 3-hydroxy-L-kynurenine + H(2)O = 3-hydroxyanthranilate + L-alanine namespace: reaction xref: KEGG:R02668 "KEGG reaction" xref: METACYC:3-HYDROXY-KYNURENINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25146 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC03227 ! 3-hydroxy-L-kynurenine relationship: has_input_compound UPa:UPC03227 {cardinality="1"} ! 3-hydroxy-L-kynurenine relationship: has_output_compound UPa:UPC00041 ! L-alanine relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00632 {cardinality="1"} ! 3-hydroxyanthranilate relationship: has_output_compound UPa:UPC00632 ! 3-hydroxyanthranilate relationship: part_of UPa:UER00329 ! quinolinate from L-kynurenine: step 2/3 relationship: part_of UPa:UER00329 {cardinality="1", direction="LR", order="1"} ! quinolinate from L-kynurenine: step 2/3 [Term] id: UPa:UCR02698 name: 4-hydroxyphenylacetate + H(+) + NADH + O(2) = (3,4-dihydroxyphenyl)acetate + H(2)O + NAD(+) namespace: reaction xref: KEGG:R02698 "KEGG reaction" xref: RHEA:16684 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00642 {cardinality="1"} ! 4-hydroxyphenylacetate relationship: has_input_compound UPa:UPC00642 ! 4-hydroxyphenylacetate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC01161 ! (3,4-dihydroxyphenyl)acetate relationship: has_output_compound UPa:UPC01161 {cardinality="1"} ! (3,4-dihydroxyphenyl)acetate relationship: part_of UPa:UER00416 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 1/7 relationship: part_of UPa:UER00416 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 1/7 [Term] id: UPa:UCR02701 name: 5-hydroxy-L-tryptophan = CO(2) + serotonin namespace: reaction xref: KEGG:R02701 "KEGG reaction" xref: METACYC:RXN3DJ-170 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18536 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00643 ! 5-hydroxy-L-tryptophan relationship: has_input_compound UPa:UPC00643 {cardinality="1"} ! 5-hydroxy-L-tryptophan relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00780 {cardinality="1"} ! serotonin relationship: has_output_compound UPa:UPC00780 ! serotonin relationship: part_of UPa:UER00814 {cardinality="1", direction="LR", order="1"} ! serotonin from L-tryptophan: step 2/2 relationship: part_of UPa:UER00814 ! serotonin from L-tryptophan: step 2/2 [Term] id: UPa:UCR02705 name: ATP + N-acetyl-D-mannosamine = ADP + N-acetyl-D-mannosamine 6-phosphate namespace: reaction xref: KEGG:R02705 "KEGG reaction" xref: METACYC:NANK-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25256 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00645 {cardinality="1"} ! N-acetyl-D-mannosamine relationship: has_input_compound UPa:UPC00645 ! N-acetyl-D-mannosamine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04257 {cardinality="1"} ! N-acetyl-D-mannosamine 6-phosphate relationship: has_output_compound UPa:UPC04257 ! N-acetyl-D-mannosamine 6-phosphate relationship: part_of UPa:UER00681 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 2/5 relationship: part_of UPa:UER00681 ! D-fructose 6-phosphate from N-acetylneuraminate: step 2/5 [Term] id: UPa:UCR02715 name: D-arabinono-1,4-lactone + O(2) = H(2)O(2) + dehydro-D-arabinono-1,4-lactone namespace: reaction xref: KEGG:R02715 "KEGG reaction" xref: METACYC:1.1.3.37-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23759 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00652 {cardinality="1"} ! D-arabinono-1,4-lactone relationship: has_input_compound UPa:UPC00652 ! D-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC06316 {cardinality="1"} ! dehydro-D-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC06316 ! dehydro-D-arabinono-1,4-lactone relationship: part_of UPa:UER00766 {cardinality="1", direction="LR", order="1"} ! dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2 relationship: part_of UPa:UER00766 ! dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2 [Term] id: UPa:UCR02733 name: H(2)O + N-acetyl-LL-2,6-diaminopimelate = LL-2,6-diaminopimelate + acetate namespace: reaction xref: KEGG:R02733 "KEGG reaction" xref: METACYC:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20408 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04390 {cardinality="1"} ! N-acetyl-LL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC04390 ! N-acetyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00666 ! LL-2,6-diaminopimelate relationship: part_of UPa:UER00024 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3 relationship: part_of UPa:UER00024 {cardinality="1", direction="LR", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3 [Term] id: UPa:UCR02734 name: H(2)O + N-succinyl-LL-2,6-diaminopimelate = LL-2,6-diaminopimelate + succinate namespace: reaction xref: KEGG:R02734 "KEGG reaction" xref: METACYC:SUCCDIAMINOPIMDESUCC-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22611 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04421 ! N-succinyl-LL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC04421 {cardinality="1"} ! N-succinyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00666 ! LL-2,6-diaminopimelate relationship: part_of UPa:UER00021 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3 relationship: part_of UPa:UER00021 {cardinality="1", direction="LR", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3 [Term] id: UPa:UCR02735 name: LL-2,6-diaminopimelate = DL-2,6-diaminopimelate namespace: reaction xref: KEGG:R02735 "KEGG reaction" xref: METACYC:DIAMINOPIMEPIM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15396 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC00666 ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00680 {cardinality="1"} ! DL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00680 ! DL-2,6-diaminopimelate relationship: part_of UPa:UER00025 {cardinality="1", direction="LR", order="1"} ! DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1 relationship: part_of UPa:UER00025 ! DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1 [Term] id: UPa:UCR02749 name: 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate namespace: reaction xref: KEGG:R02749 "KEGG reaction" xref: METACYC:D-PPENTOMUT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25208 "Rhea reaction" xref: RHEA:27661 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00672 {cardinality="1"} ! 2-deoxy-alpha-D-ribose 1-phosphate relationship: has_input_compound UPa:UPC00672 ! 2-deoxy-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC00673 ! 2-deoxy-D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00673 {cardinality="1"} ! 2-deoxy-D-ribose 5-phosphate relationship: part_of UPa:UER00467 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2 relationship: part_of UPa:UER00467 ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2 [Term] id: UPa:UCR02752 name: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O namespace: reaction xref: KEGG:R02752 "KEGG reaction" xref: METACYC:GLUCARDEHYDRA-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14576 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00818 ! D-glucarate relationship: has_input_compound UPa:UPC00818 {cardinality="1"} ! D-glucarate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00679 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucarate relationship: has_output_compound UPa:UPC00679 ! 5-dehydro-4-deoxy-D-glucarate relationship: part_of UPa:UER00627 ! 2,5-dioxopentanoate from D-glucarate: step 1/2 relationship: part_of UPa:UER00627 {cardinality="1", direction="LR", order="1"} ! 2,5-dioxopentanoate from D-glucarate: step 1/2 [Term] id: UPa:UCR02754 name: 5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate namespace: reaction xref: KEGG:R02754 "KEGG reaction" xref: METACYC:KDGALDOL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:27729 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00679 ! 5-dehydro-4-deoxy-D-glucarate relationship: has_input_compound UPa:UPC00679 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucarate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate relationship: has_output_compound UPa:UPC01146 {cardinality="1"} ! 2-hydroxy-3-oxopropanoate relationship: part_of UPa:UER00630 {cardinality="1", direction="LR", order="1"} ! D-glycerate from galactarate: step 2/3 relationship: part_of UPa:UER00630 ! D-glycerate from galactarate: step 2/3 [Term] id: UPa:UCR02755 name: DL-2,6-diaminopimelate + H(2)O + NADP(+) = (S)-2-amino-6-oxopimelate + H(+) + NADPH + NH(3) namespace: reaction xref: KEGG:R02755 "KEGG reaction" xref: METACYC:DIAMINOPIMELATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13564 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00680 ! DL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC00680 {cardinality="1"} ! DL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC03871 {cardinality="1"} ! (S)-2-amino-6-oxopimelate relationship: has_output_compound UPa:UPC03871 ! (S)-2-amino-6-oxopimelate relationship: part_of UPa:UER00026 {cardinality="1", direction="RL", order="2"} ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1 relationship: part_of UPa:UER00026 ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1 [Term] id: UPa:UCR02765 name: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA namespace: reaction xref: KEGG:R02765 "KEGG reaction" xref: METACYC:METHYLMALONYL-COA-EPIM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20556 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01213 ! (R)-methylmalonyl-CoA relationship: has_input_compound UPa:UPC01213 {cardinality="1"} ! (R)-methylmalonyl-CoA relationship: has_output_compound UPa:UPC00683 ! (S)-methylmalonyl-CoA relationship: has_output_compound UPa:UPC00683 {cardinality="1"} ! (S)-methylmalonyl-CoA relationship: part_of UPa:UER00909 {cardinality="1", direction="RL", order="1"} ! succinyl-CoA from propanoyl-CoA: step 2/3 relationship: part_of UPa:UER00909 ! succinyl-CoA from propanoyl-CoA: step 2/3 [Term] id: UPa:UCR02782 name: scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O namespace: reaction xref: KEGG:R02782 "KEGG reaction" xref: METACYC:MYO-INOSOSE-2-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14068 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00691 {cardinality="1"} ! scyllo-inosose relationship: has_input_compound UPa:UPC00691 ! scyllo-inosose relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC04287 ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione relationship: has_output_compound UPa:UPC04287 {cardinality="1"} ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione relationship: part_of UPa:UER00144 ! acetyl-CoA from myo-inositol: step 2/7 relationship: part_of UPa:UER00144 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 2/7 [Term] id: UPa:UCR02804 name: H(2)O + dinitrogen + 2 ferricytochrome c = 2 H(+) + 2 ferrocytochrome c + nitrous oxide namespace: reaction xref: KEGG:R02804 "KEGG reaction" xref: METACYC:RXN-12130 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15496 "Rhea reaction" xref: RHEA:43111 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00125 ! ferricytochrome c relationship: has_input_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c relationship: has_input_compound UPa:UPC00697 ! dinitrogen relationship: has_input_compound UPa:UPC00697 {cardinality="1"} ! dinitrogen relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00126 ! ferrocytochrome c relationship: has_output_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c relationship: has_output_compound UPa:UPC00887 ! nitrous oxide relationship: has_output_compound UPa:UPC00887 {cardinality="1"} ! nitrous oxide relationship: part_of UPa:UER00709 {cardinality="1", direction="RL", order="1"} ! dinitrogen from nitrate: step 4/4 relationship: part_of UPa:UER00709 ! dinitrogen from nitrate: step 4/4 [Term] id: UPa:UCR02821 name: L-homocysteine + betaine = L-methionine + N,N-dimethylglycine namespace: reaction xref: KEGG:R02821 "KEGG reaction" xref: METACYC:2.1.1.5-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22339 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_input_compound UPa:UPC00719 ! betaine relationship: has_input_compound UPa:UPC00719 {cardinality="1"} ! betaine relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC01026 {cardinality="1"} ! N,N-dimethylglycine relationship: has_output_compound UPa:UPC01026 ! N,N-dimethylglycine relationship: part_of UPa:UER00083 ! L-methionine from L-homocysteine (BhmT route): step 1/1 relationship: part_of UPa:UER00083 {cardinality="1", direction="LR", order="1"} ! L-methionine from L-homocysteine (BhmT route): step 1/1 relationship: part_of UPa:UER00432 ! sarcosine from betaine: step 1/2 relationship: part_of UPa:UER00432 {cardinality="1", direction="LR", order="1"} ! sarcosine from betaine: step 1/2 [Term] id: UPa:UCR02860 name: H(2)O + acceptor + nicotine = (S)-6-hydroxynicotine + reduced acceptor namespace: reaction xref: KEGG:R02860 "KEGG reaction" xref: METACYC:NICOTINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14772 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC16150 {cardinality="1"} ! nicotine relationship: has_input_compound UPa:UPC16150 ! nicotine relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC01056 ! (S)-6-hydroxynicotine relationship: has_output_compound UPa:UPC01056 {cardinality="1"} ! (S)-6-hydroxynicotine relationship: part_of UPa:UER00487 ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route): step 1/2 relationship: part_of UPa:UER00487 {cardinality="1", direction="LR", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route): step 1/2 [Term] id: UPa:UCR02864 name: 2 H(+) + siroheme = Fe2+ + sirohydrochlorin namespace: reaction xref: KEGG:R02864 "KEGG reaction" xref: METACYC:SIROHEME-FERROCHELAT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24363 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00748 ! siroheme relationship: has_input_compound UPa:UPC00748 {cardinality="1"} ! siroheme relationship: has_output_compound UPa:UPC05778 ! sirohydrochlorin relationship: has_output_compound UPa:UPC05778 {cardinality="1"} ! sirohydrochlorin relationship: has_output_compound UPa:UPC14818 ! Fe2+ relationship: has_output_compound UPa:UPC14818 {cardinality="1"} ! Fe2+ relationship: part_of UPa:UER00376 {cardinality="1", direction="RL", order="1"} ! siroheme from sirohydrochlorin: step 1/1 relationship: part_of UPa:UER00376 ! siroheme from sirohydrochlorin: step 1/1 [Term] id: UPa:UCR02869 name: S-adenosylmethioninamine + spermidine = S-methyl-5'-thioadenosine + spermine namespace: reaction xref: KEGG:R02869 "KEGG reaction" xref: METACYC:SPERMINE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19976 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00315 {cardinality="1"} ! spermidine relationship: has_input_compound UPa:UPC00315 ! spermidine relationship: has_input_compound UPa:UPC01137 {cardinality="1"} ! S-adenosylmethioninamine relationship: has_input_compound UPa:UPC01137 ! S-adenosylmethioninamine relationship: has_output_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00750 {cardinality="1"} ! spermine relationship: has_output_compound UPa:UPC00750 ! spermine relationship: part_of UPa:UER00315 ! spermine from spermidine: step 1/1 relationship: part_of UPa:UER00315 {cardinality="1", direction="LR", order="1"} ! spermine from spermidine: step 1/1 [Term] id: UPa:UCR02874 name: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+) namespace: reaction xref: KEGG:R02874 "KEGG reaction" xref: METACYC:SQUALENE-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25285 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00751 {cardinality="1"} ! squalene relationship: has_input_compound UPa:UPC00751 ! squalene relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC01054 {cardinality="1"} ! (S)-2,3-epoxysqualene relationship: has_output_compound UPa:UPC01054 ! (S)-2,3-epoxysqualene relationship: part_of UPa:UER00752 {cardinality="1", direction="LR", order="1"} ! lanosterol from farnesyl diphosphate: step 2/3 relationship: part_of UPa:UER00752 ! lanosterol from farnesyl diphosphate: step 2/3 [Term] id: UPa:UCR02911 name: acetyl-CoA + serotonin = CoA + N-acetylserotonin namespace: reaction xref: KEGG:R02911 "KEGG reaction" xref: METACYC:RXN3DJ-35528 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25220 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00780 ! serotonin relationship: has_input_compound UPa:UPC00780 {cardinality="1"} ! serotonin relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00978 ! N-acetylserotonin relationship: has_output_compound UPa:UPC00978 {cardinality="1"} ! N-acetylserotonin relationship: part_of UPa:UER00815 ! melatonin from serotonin: step 1/2 relationship: part_of UPa:UER00815 {cardinality="1", direction="LR", order="1"} ! melatonin from serotonin: step 1/2 [Term] id: UPa:UCR02914 name: 4-imidazolone-5-propanoate = H(2)O + trans-urocanate namespace: reaction xref: KEGG:R02914 "KEGG reaction" xref: METACYC:UROCANATE-HYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13104 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03680 ! 4-imidazolone-5-propanoate relationship: has_input_compound UPa:UPC03680 {cardinality="1"} ! 4-imidazolone-5-propanoate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00785 {cardinality="1"} ! trans-urocanate relationship: has_output_compound UPa:UPC00785 ! trans-urocanate relationship: part_of UPa:UER00550 {cardinality="1", direction="RL", order="1"} ! N-formimidoyl-L-glutamate from L-histidine: step 2/3 relationship: part_of UPa:UER00550 ! N-formimidoyl-L-glutamate from L-histidine: step 2/3 [Term] id: UPa:UCR02922 name: H(2)O + creatinine = N-methylhydantoin + NH(3) namespace: reaction xref: KEGG:R02922 "KEGG reaction" xref: METACYC:CREATININE-DEAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12684 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00791 {cardinality="1"} ! creatinine relationship: has_input_compound UPa:UPC00791 ! creatinine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC02565 ! N-methylhydantoin relationship: has_output_compound UPa:UPC02565 {cardinality="1"} ! N-methylhydantoin relationship: part_of UPa:UER00395 ! sarcosine from creatinine: step 1/3 relationship: part_of UPa:UER00395 {cardinality="1", direction="LR", order="1"} ! sarcosine from creatinine: step 1/3 [Term] id: UPa:UCR02933 name: H(2)O + L-gulono-1,4-lactone = L-gulonate namespace: reaction xref: KEGG:R02933 "KEGG reaction" xref: METACYC:RXN-8783 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42519 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC01040 ! L-gulono-1,4-lactone relationship: has_input_compound UPa:UPC01040 {cardinality="1"} ! L-gulono-1,4-lactone relationship: has_output_compound UPa:UPC00800 {cardinality="1"} ! L-gulonate relationship: has_output_compound UPa:UPC00800 ! L-gulonate relationship: part_of UPa:UER00938 ! L-ascorbate from UDP-alpha-D-glucuronate: step 3/4 relationship: part_of UPa:UER00938 {cardinality="1", direction="RL", order="1"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 3/4 [Term] id: UPa:UCR02935 name: (S)-ureidoglycolate + NAD(+) = H(+) + NADH + oxalurate namespace: reaction xref: KEGG:R02935 "KEGG reaction" xref: RHEA:15332 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: has_input_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00802 {cardinality="1"} ! oxalurate relationship: has_output_compound UPa:UPC00802 ! oxalurate relationship: part_of UPa:UER00975 ! None relationship: part_of UPa:UER00975 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR02936 name: (S)-ureidoglycolate + NADP(+) = H(+) + NADPH + oxalurate namespace: reaction xref: KEGG:R02936 "KEGG reaction" xref: METACYC:R165-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15336 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: has_input_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00802 {cardinality="1"} ! oxalurate relationship: has_output_compound UPa:UPC00802 ! oxalurate relationship: part_of UPa:UER00976 ! None relationship: part_of UPa:UER00976 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR02946 name: (R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH namespace: reaction xref: KEGG:R02946 "KEGG reaction" xref: METACYC:RR-BUTANEDIOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24343 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC03044 {cardinality="1"} ! (R,R)-butane-2,3-diol relationship: has_input_compound UPa:UPC03044 ! (R,R)-butane-2,3-diol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00810 ! (R)-acetoin relationship: has_output_compound UPa:UPC00810 {cardinality="1"} ! (R)-acetoin relationship: part_of UPa:UER00679 ! (R,R)-butane-2,3-diol from pyruvate: step 3/3 relationship: part_of UPa:UER00679 {cardinality="1", direction="RL", order="1"} ! (R,R)-butane-2,3-diol from pyruvate: step 3/3 [Term] id: UPa:UCR02948 name: (S)-2-acetolactate = (R)-acetoin + CO(2) namespace: reaction xref: KEGG:R02948 "KEGG reaction" xref: METACYC:ACETOLACTATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21583 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06010 ! (S)-2-acetolactate relationship: has_input_compound UPa:UPC06010 {cardinality="1"} ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00810 ! (R)-acetoin relationship: has_output_compound UPa:UPC00810 {cardinality="1"} ! (R)-acetoin relationship: part_of UPa:UER00678 ! (R,R)-butane-2,3-diol from pyruvate: step 2/3 relationship: part_of UPa:UER00678 {cardinality="1", direction="LR", order="1"} ! (R,R)-butane-2,3-diol from pyruvate: step 2/3 [Term] id: UPa:UCR02988 name: 3-oxoadipate + NAD(+) = H(+) + NADH + maleylacetate namespace: reaction xref: KEGG:R02988 "KEGG reaction" xref: RHEA:16984 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00846 ! 3-oxoadipate relationship: has_input_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC02222 ! maleylacetate relationship: has_output_compound UPa:UPC02222 {cardinality="1"} ! maleylacetate relationship: part_of UPa:UER00957 {cardinality="1", direction="RL", order="1"} ! None relationship: part_of UPa:UER00957 ! None [Term] id: UPa:UCR02989 name: 3-oxoadipate + NADP(+) = H(+) + NADPH + maleylacetate namespace: reaction xref: KEGG:R02989 "KEGG reaction" xref: METACYC:MALEYLACETATE-REDUCTASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16988 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00846 ! 3-oxoadipate relationship: has_input_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC02222 ! maleylacetate relationship: has_output_compound UPa:UPC02222 {cardinality="1"} ! maleylacetate relationship: part_of UPa:UER00958 {cardinality="1", direction="RL", order="1"} ! None relationship: part_of UPa:UER00958 ! None [Term] id: UPa:UCR02990 name: 3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate namespace: reaction xref: KEGG:R02990 "KEGG reaction" xref: METACYC:3-OXOADIPATE-COA-TRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12051 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00846 ! 3-oxoadipate relationship: has_input_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC02232 {cardinality="1"} ! 3-oxoadipyl-CoA relationship: has_output_compound UPa:UPC02232 ! 3-oxoadipyl-CoA relationship: part_of UPa:UER00262 ! acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 1/2 relationship: part_of UPa:UER00262 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 1/2 [Term] id: UPa:UCR02991 name: 5-oxo-4,5-dihydro-2-furylacetate + H(2)O = 3-oxoadipate namespace: reaction xref: KEGG:R02991 "KEGG reaction" xref: METACYC:3-OXOADIPATE-ENOL-LACTONASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10187 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC03586 ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_input_compound UPa:UPC03586 {cardinality="1"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_output_compound UPa:UPC00846 ! 3-oxoadipate relationship: has_output_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate relationship: part_of UPa:UER00261 {cardinality="1", direction="LR", order="1"} ! 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate: step 1/1 relationship: part_of UPa:UER00261 ! 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate: step 1/1 [Term] id: UPa:UCR02992 name: 4-pyridoxolactone + H(2)O = 4-pyridoxate namespace: reaction xref: KEGG:R02992 "KEGG reaction" xref: METACYC:4-PYRIDOXOLACTONASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14304 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00971 {cardinality="1"} ! 4-pyridoxolactone relationship: has_input_compound UPa:UPC00971 ! 4-pyridoxolactone relationship: has_output_compound UPa:UPC00847 {cardinality="1"} ! 4-pyridoxate relationship: has_output_compound UPa:UPC00847 ! 4-pyridoxate relationship: part_of UPa:UER00589 ! 4-pyridoxate from pyridoxal: step 2/2 relationship: part_of UPa:UER00589 {cardinality="1", direction="LR", order="1"} ! 4-pyridoxate from pyridoxal: step 2/2 [Term] id: UPa:UCR03005 name: ATP + nicotinate D-ribonucleotide = deamido-NAD(+) + diphosphate namespace: reaction xref: KEGG:R03005 "KEGG reaction" xref: METACYC:NICONUCADENYLYLTRAN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22863 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide relationship: has_input_compound UPa:UPC01185 ! nicotinate D-ribonucleotide relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00857 {cardinality="1"} ! deamido-NAD(+) relationship: has_output_compound UPa:UPC00857 ! deamido-NAD(+) relationship: part_of UPa:UER00332 ! deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1 relationship: part_of UPa:UER00332 {cardinality="1", direction="LR", order="1"} ! deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1 [Term] id: UPa:UCR03013 name: H(2)O + L-histidinol phosphate = L-histidinol + phosphate namespace: reaction xref: KEGG:R03013 "KEGG reaction" xref: METACYC:HISTIDPHOS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14468 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01100 {cardinality="1"} ! L-histidinol phosphate relationship: has_input_compound UPa:UPC01100 ! L-histidinol phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00860 {cardinality="1"} ! L-histidinol relationship: has_output_compound UPa:UPC00860 ! L-histidinol relationship: part_of UPa:UER00013 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9 relationship: part_of UPa:UER00013 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9 [Term] id: UPa:UCR03014 name: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate namespace: reaction xref: KEGG:R03014 "KEGG reaction" xref: METACYC:RHAMNULOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20120 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00861 {cardinality="1"} ! L-rhamnulose relationship: has_input_compound UPa:UPC00861 ! L-rhamnulose relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC01131 {cardinality="1"} ! L-rhamnulose 1-phosphate relationship: has_output_compound UPa:UPC01131 ! L-rhamnulose 1-phosphate relationship: part_of UPa:UER00602 ! glycerone phosphate from L-rhamnose: step 2/3 relationship: part_of UPa:UER00602 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from L-rhamnose: step 2/3 [Term] id: UPa:UCR03015 name: H(2)O + N-formylmethanofuran + acceptor = CO(2) + methanofuran + reduced acceptor namespace: reaction xref: KEGG:R03015 "KEGG reaction" xref: METACYC:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19844 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC01001 {cardinality="1"} ! N-formylmethanofuran relationship: has_input_compound UPa:UPC01001 ! N-formylmethanofuran relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00862 {cardinality="1"} ! methanofuran relationship: has_output_compound UPa:UPC00862 ! methanofuran relationship: part_of UPa:UER00692 {cardinality="1", direction="RL", order="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3 relationship: part_of UPa:UER00692 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3 [Term] id: UPa:UCR03018 name: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP namespace: reaction xref: KEGG:R03018 "KEGG reaction" xref: METACYC:PANTOTHENATE-KIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16376 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00864 {cardinality="1"} ! (R)-pantothenate relationship: has_input_compound UPa:UPC00864 ! (R)-pantothenate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC03492 {cardinality="1"} ! (R)-4'-phosphopantothenate relationship: has_output_compound UPa:UPC03492 ! (R)-4'-phosphopantothenate relationship: part_of UPa:UER00352 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 1/5 relationship: part_of UPa:UER00352 ! CoA from (R)-pantothenate: step 1/5 [Term] id: UPa:UCR03028 name: glutaconyl-1-CoA = CO(2) + crotonoyl-CoA namespace: reaction xref: KEGG:R03028 "KEGG reaction" xref: METACYC:GLUTACONYL-COA-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23975 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02411 {cardinality="1"} ! glutaconyl-1-CoA relationship: has_input_compound UPa:UPC02411 ! glutaconyl-1-CoA relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00877 ! crotonoyl-CoA relationship: has_output_compound UPa:UPC00877 {cardinality="1"} ! crotonoyl-CoA relationship: part_of UPa:UER00688 ! crotonoyl-CoA from L-glutamate: step 5/5 relationship: part_of UPa:UER00688 {cardinality="1", direction="LR", order="1"} ! crotonoyl-CoA from L-glutamate: step 5/5 [Term] id: UPa:UCR03033 name: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O namespace: reaction xref: KEGG:R03033 "KEGG reaction" xref: METACYC:GALACTONDEHYDRAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18652 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00880 {cardinality="1"} ! D-galactonate relationship: has_input_compound UPa:UPC00880 ! D-galactonate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01216 ! 2-dehydro-3-deoxy-D-galactonate relationship: has_output_compound UPa:UPC01216 {cardinality="1"} ! 2-dehydro-3-deoxy-D-galactonate relationship: part_of UPa:UER00518 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3 relationship: part_of UPa:UER00518 ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3 [Term] id: UPa:UCR03035 name: ATP + pantotheine 4'-phosphate = 3'-dephospho-CoA + diphosphate namespace: reaction xref: KEGG:R03035 "KEGG reaction" xref: METACYC:PANTEPADENYLYLTRAN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19804 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01134 ! pantotheine 4'-phosphate relationship: has_input_compound UPa:UPC01134 {cardinality="1"} ! pantotheine 4'-phosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00882 {cardinality="1"} ! 3'-dephospho-CoA relationship: has_output_compound UPa:UPC00882 ! 3'-dephospho-CoA relationship: part_of UPa:UER00355 ! CoA from (R)-pantothenate: step 4/5 relationship: part_of UPa:UER00355 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 4/5 [Term] id: UPa:UCR03067 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate namespace: reaction xref: KEGG:R03067 "KEGG reaction" xref: METACYC:H2PTEROATESYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19952 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00568 {cardinality="1"} ! 4-aminobenzoate relationship: has_input_compound UPa:UPC00568 ! 4-aminobenzoate relationship: has_input_compound UPa:UPC04807 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: has_input_compound UPa:UPC04807 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00921 {cardinality="1"} ! 7,8-dihydropteroate relationship: has_output_compound UPa:UPC00921 ! 7,8-dihydropteroate relationship: part_of UPa:UER00156 {cardinality="1", direction="LR", order="1"} ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2 relationship: part_of UPa:UER00156 ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2 [Term] id: UPa:UCR03069 name: H(2)O + dimethylmaleate = (2R,3S)-2,3-dimethylmalate namespace: reaction xref: KEGG:R03069 "KEGG reaction" xref: METACYC:DIMETHYLMALEATE-HYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20256 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00922 ! dimethylmaleate relationship: has_input_compound UPa:UPC00922 {cardinality="1"} ! dimethylmaleate relationship: has_output_compound UPa:UPC03652 {cardinality="1"} ! (2R,3S)-2,3-dimethylmalate relationship: has_output_compound UPa:UPC03652 ! (2R,3S)-2,3-dimethylmalate relationship: part_of UPa:UER01018 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 7/8 relationship: part_of UPa:UER01018 ! propanoate and pyruvate from 6-hydroxynicotinate: step 7/8 [Term] id: UPa:UCR03070 name: 2-methylene-3-methylsuccinate = dimethylmaleate namespace: reaction xref: KEGG:R03070 "KEGG reaction" xref: METACYC:METHYLITACONATE-DELTA-ISOMERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23483 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02295 {cardinality="1"} ! 2-methylene-3-methylsuccinate relationship: has_input_compound UPa:UPC02295 ! 2-methylene-3-methylsuccinate relationship: has_output_compound UPa:UPC00922 {cardinality="1"} ! dimethylmaleate relationship: has_output_compound UPa:UPC00922 ! dimethylmaleate relationship: part_of UPa:UER01017 ! propanoate and pyruvate from 6-hydroxynicotinate: step 6/8 relationship: part_of UPa:UER01017 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 6/8 [Term] id: UPa:UCR03083 name: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate namespace: reaction xref: KEGG:R03083 "KEGG reaction" xref: METACYC:3-DEHYDROQUINATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21971 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04691 ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate relationship: has_input_compound UPa:UPC04691 {cardinality="1"} ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00944 ! 3-dehydroquinate relationship: part_of UPa:UER00085 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7 relationship: part_of UPa:UER00085 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7 [Term] id: UPa:UCR03084 name: 3-dehydroquinate = 3-dehydroshikimate + H(2)O namespace: reaction xref: KEGG:R03084 "KEGG reaction" xref: METACYC:3-DEHYDROQUINATE-DEHYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21099 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00944 ! 3-dehydroquinate relationship: has_input_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC02637 ! 3-dehydroshikimate relationship: has_output_compound UPa:UPC02637 {cardinality="1"} ! 3-dehydroshikimate relationship: part_of UPa:UER00086 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7 relationship: part_of UPa:UER00086 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7 relationship: part_of UPa:UER00178 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2 relationship: part_of UPa:UER00178 ! 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2 [Term] id: UPa:UCR03098 name: ATP + L-alpha-aminoadipate = alpha-aminoadipoyl-C6-AMP + diphosphate namespace: reaction xref: KEGG:R03098 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC05560 {cardinality="1"} ! alpha-aminoadipoyl-C6-AMP relationship: has_output_compound UPa:UPC05560 ! alpha-aminoadipoyl-C6-AMP relationship: part_of UPa:UER00032 ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3 relationship: part_of UPa:UER00032 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3 [Term] id: UPa:UCR03102 name: H(2)O + L-2-aminoadipate 6-semialdahyde + NAD(+) = H(+) + L-alpha-aminoadipate + NADH namespace: reaction xref: KEGG:R03102 "KEGG reaction" xref: METACYC:ALLYSINE-DEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12311 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: has_input_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: part_of UPa:UER00985 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00985 ! None [Term] id: UPa:UCR03103 name: H(2)O + L-2-aminoadipate 6-semialdahyde + NADP(+) = H(+) + L-alpha-aminoadipate + NADPH namespace: reaction xref: KEGG:R03103 "KEGG reaction" xref: METACYC:1.2.1.31-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12307 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: has_input_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: part_of UPa:UER00986 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00986 ! None [Term] id: UPa:UCR03119 name: NAD(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADH namespace: reaction xref: KEGG:R03119 "KEGG reaction" xref: METACYC:13-PROPANEDIOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23191 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC02457 ! propane-1,3-diol relationship: has_input_compound UPa:UPC02457 {cardinality="1"} ! propane-1,3-diol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00969 ! 3-hydroxypropanal relationship: has_output_compound UPa:UPC00969 {cardinality="1"} ! 3-hydroxypropanal relationship: part_of UPa:UER00671 ! propane-1,3-diol from glycerol (reductive route): step 2/2 relationship: part_of UPa:UER00671 {cardinality="1", direction="RL", order="1"} ! propane-1,3-diol from glycerol (reductive route): step 2/2 [Term] id: UPa:UCR03130 name: N-acetylserotonin + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + melatonin namespace: reaction xref: KEGG:R03130 "KEGG reaction" xref: METACYC:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15576 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00978 {cardinality="1"} ! N-acetylserotonin relationship: has_input_compound UPa:UPC00978 ! N-acetylserotonin relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC01598 {cardinality="1"} ! melatonin relationship: has_output_compound UPa:UPC01598 ! melatonin relationship: part_of UPa:UER00816 ! melatonin from serotonin: step 2/2 relationship: part_of UPa:UER00816 {cardinality="1", direction="LR", order="1"} ! melatonin from serotonin: step 2/2 [Term] id: UPa:UCR03163 name: L-fucose = L-fuculose namespace: reaction xref: KEGG:R03163 "KEGG reaction" xref: METACYC:FUCISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17236 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01019 ! L-fucose relationship: has_input_compound UPa:UPC01019 {cardinality="1"} ! L-fucose relationship: has_output_compound UPa:UPC01721 {cardinality="1"} ! L-fuculose relationship: has_output_compound UPa:UPC01721 ! L-fuculose relationship: part_of UPa:UER00624 ! L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3 relationship: part_of UPa:UER00624 {cardinality="1", direction="LR", order="1"} ! L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3 [Term] id: UPa:UCR03164 name: 6-hydroxynicotinate + reduced ferredoxin = 6-hydroxynicotinate + oxidized ferredoxin namespace: reaction xref: KEGG:R03164 "KEGG reaction" xref: METACYC:6-HYDROXYNICOTINATE-REDUCTASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17228 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin relationship: has_input_compound UPa:UPC00138 ! reduced ferredoxin relationship: has_input_compound UPa:UPC01020 ! 6-hydroxynicotinate relationship: has_input_compound UPa:UPC01020 {cardinality="1"} ! 6-hydroxynicotinate relationship: has_output_compound UPa:UPC00139 ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC04226 {cardinality="1"} ! 6-hydroxynicotinate relationship: has_output_compound UPa:UPC04226 ! 6-hydroxynicotinate relationship: part_of UPa:UER01012 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 1/8 relationship: part_of UPa:UER01012 ! propanoate and pyruvate from 6-hydroxynicotinate: step 1/8 [Term] id: UPa:UCR03165 name: hydroxymethylbilane = H(2)O + uroporphyrinogen III namespace: reaction xref: KEGG:R03165 "KEGG reaction" xref: METACYC:UROGENIIISYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18968 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01024 ! hydroxymethylbilane relationship: has_input_compound UPa:UPC01024 {cardinality="1"} ! hydroxymethylbilane relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01051 {cardinality="1"} ! uroporphyrinogen III relationship: has_output_compound UPa:UPC01051 ! uroporphyrinogen III relationship: part_of UPa:UER00320 {cardinality="1", direction="LR", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate: step 3/4 relationship: part_of UPa:UER00320 ! coproporphyrinogen-III from 5-aminolevulinate: step 3/4 [Term] id: UPa:UCR03181 name: 4-maleylacetoacetate = 4-fumarylacetoacetate namespace: reaction xref: KEGG:R03181 "KEGG reaction" xref: METACYC:MALEYLACETOACETATE-ISOMERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14820 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01036 ! 4-maleylacetoacetate relationship: has_input_compound UPa:UPC01036 {cardinality="1"} ! 4-maleylacetoacetate relationship: has_output_compound UPa:UPC01061 {cardinality="1"} ! 4-fumarylacetoacetate relationship: has_output_compound UPa:UPC01061 ! 4-fumarylacetoacetate relationship: part_of UPa:UER00340 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 5/6 relationship: part_of UPa:UER00340 ! acetoacetate and fumarate from L-phenylalanine: step 5/6 [Term] id: UPa:UCR03182 name: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + phosphate namespace: reaction xref: KEGG:R03182 "KEGG reaction" xref: METACYC:DETHIOBIOTIN-SYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15808 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC01037 ! 7,8-diaminononanoate relationship: has_input_compound UPa:UPC01037 {cardinality="1"} ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC01909 {cardinality="1"} ! dethiobiotin relationship: has_output_compound UPa:UPC01909 ! dethiobiotin relationship: part_of UPa:UER00161 ! biotin from 7,8-diaminononanoate: step 1/2 relationship: part_of UPa:UER00161 {cardinality="1", direction="LR", order="1"} ! biotin from 7,8-diaminononanoate: step 1/2 [Term] id: UPa:UCR03184 name: L-gulono-1,4-lactone + O(2) = H(2)O(2) + L-xylo-hexulonolactone namespace: reaction xref: KEGG:R03184 "KEGG reaction" xref: METACYC:L-GULONOLACTONE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12355 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC01040 ! L-gulono-1,4-lactone relationship: has_input_compound UPa:UPC01040 {cardinality="1"} ! L-gulono-1,4-lactone relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC03289 {cardinality="1"} ! L-xylo-hexulonolactone relationship: has_output_compound UPa:UPC03289 ! L-xylo-hexulonolactone relationship: part_of UPa:UER00939 ! L-ascorbate from UDP-alpha-D-glucuronate: step 4/4 relationship: part_of UPa:UER00939 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 4/4 [Term] id: UPa:UCR03187 name: ATP + 2 H(2)O + N-methylhydantoin = ADP + N-carbamoylsarcosine + phosphate namespace: reaction xref: KEGG:R03187 "KEGG reaction" xref: METACYC:3.5.2.14-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11723 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC02565 {cardinality="1"} ! N-methylhydantoin relationship: has_input_compound UPa:UPC02565 ! N-methylhydantoin relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC01043 {cardinality="1"} ! N-carbamoylsarcosine relationship: has_output_compound UPa:UPC01043 ! N-carbamoylsarcosine relationship: part_of UPa:UER00396 ! sarcosine from creatinine: step 2/3 relationship: part_of UPa:UER00396 {cardinality="1", direction="LR", order="1"} ! sarcosine from creatinine: step 2/3 [Term] id: UPa:UCR03194 name: 2 S-adenosyl-L-methionine + uroporphyrinogen III = 2 S-adenosyl-L-homocysteine + precorrin-2 namespace: reaction xref: KEGG:R03194 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01051 {cardinality="1"} ! uroporphyrinogen III relationship: has_input_compound UPa:UPC01051 ! uroporphyrinogen III relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC02463 {cardinality="1"} ! precorrin-2 relationship: has_output_compound UPa:UPC02463 ! precorrin-2 relationship: part_of UPa:UER00211 {cardinality="1", direction="LR", order="1"} ! precorrin-2 from uroporphyrinogen III: step 1/1 relationship: part_of UPa:UER00211 ! precorrin-2 from uroporphyrinogen III: step 1/1 [Term] id: UPa:UCR03197 name: uroporphyrinogen III = 4 CO(2) + coproporphyrinogen-III namespace: reaction xref: KEGG:R03197 "KEGG reaction" xref: METACYC:UROGENDECARBOX-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19868 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01051 ! uroporphyrinogen III relationship: has_input_compound UPa:UPC01051 {cardinality="1"} ! uroporphyrinogen III relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC03263 ! coproporphyrinogen-III relationship: has_output_compound UPa:UPC03263 {cardinality="1"} ! coproporphyrinogen-III relationship: part_of UPa:UER00321 ! coproporphyrinogen-III from 5-aminolevulinate: step 4/4 relationship: part_of UPa:UER00321 {cardinality="1", direction="LR", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate: step 4/4 [Term] id: UPa:UCR03199 name: (S)-2,3-epoxysqualene = lanosterol namespace: reaction xref: KEGG:R03199 "KEGG reaction" xref: METACYC:LANOSTEROL-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14624 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01054 ! (S)-2,3-epoxysqualene relationship: has_input_compound UPa:UPC01054 {cardinality="1"} ! (S)-2,3-epoxysqualene relationship: has_output_compound UPa:UPC01724 ! lanosterol relationship: has_output_compound UPa:UPC01724 {cardinality="1"} ! lanosterol relationship: part_of UPa:UER00753 ! lanosterol from farnesyl diphosphate: step 3/3 relationship: part_of UPa:UER00753 {cardinality="1", direction="LR", order="1"} ! lanosterol from farnesyl diphosphate: step 3/3 [Term] id: UPa:UCR03202 name: (S)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2) namespace: reaction xref: KEGG:R03202 "KEGG reaction" xref: METACYC:S-6-HYDROXYNICOTINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11883 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC01056 {cardinality="1"} ! (S)-6-hydroxynicotine relationship: has_input_compound UPa:UPC01056 ! (S)-6-hydroxynicotine relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC01297 ! 6-hydroxypseudooxynicotine relationship: has_output_compound UPa:UPC01297 {cardinality="1"} ! 6-hydroxypseudooxynicotine relationship: part_of UPa:UER00919 ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route): step 2/2 relationship: part_of UPa:UER00919 {cardinality="1", direction="LR", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route): step 2/2 [Term] id: UPa:UCR03209 name: ATP + CoA + pimelate = AMP + diphosphate + pimeloyl-CoA namespace: reaction xref: KEGG:R03209 "KEGG reaction" xref: METACYC:6-CARBOXYHEXANOATE--COA-LIGASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14784 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC02656 {cardinality="1"} ! pimelate relationship: has_input_compound UPa:UPC02656 ! pimelate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC01063 ! pimeloyl-CoA relationship: has_output_compound UPa:UPC01063 {cardinality="1"} ! pimeloyl-CoA relationship: part_of UPa:UER00351 ! pimeloyl-CoA from pimelate: step 1/1 relationship: part_of UPa:UER00351 {cardinality="1", direction="LR", order="1"} ! pimeloyl-CoA from pimelate: step 1/1 [Term] id: UPa:UCR03210 name: L-alanine + pimeloyl-CoA = 8-amino-7-oxononanoate + CO(2) + CoA namespace: reaction xref: KEGG:R03210 "KEGG reaction" xref: METACYC:7KAPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20715 "Rhea reaction" xref: RHEA:42291 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_input_compound UPa:UPC01063 ! pimeloyl-CoA relationship: has_input_compound UPa:UPC01063 {cardinality="1"} ! pimeloyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC01092 ! 8-amino-7-oxononanoate relationship: has_output_compound UPa:UPC01092 {cardinality="1"} ! 8-amino-7-oxononanoate relationship: part_of UPa:UER00159 {cardinality="1", direction="LR", order="1"} ! 8-amino-7-oxononanoate from pimeloyl-CoA: step 1/1 relationship: part_of UPa:UER00159 ! 8-amino-7-oxononanoate from pimeloyl-CoA: step 1/1 [Term] id: UPa:UCR03217 name: L-cysteine + O-acetyl-L-homoserine = L-cystathionine + acetate namespace: reaction xref: KEGG:R03217 "KEGG reaction" xref: METACYC:RXN-721 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:30934 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_input_compound UPa:UPC01077 ! O-acetyl-L-homoserine relationship: has_input_compound UPa:UPC01077 {cardinality="1"} ! O-acetyl-L-homoserine relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: has_output_compound UPa:UPC02291 ! L-cystathionine relationship: part_of UPa:UER00448 ! L-cystathionine from O-acetyl-L-homoserine: step 1/1 relationship: part_of UPa:UER00448 {cardinality="1", direction="LR", order="1"} ! L-cystathionine from O-acetyl-L-homoserine: step 1/1 [Term] id: UPa:UCR03220 name: O(2) + coproporphyrinogen-III = 2 CO(2) + 2 H(2)O + protoporphyrinogen-IX namespace: reaction xref: KEGG:R03220 "KEGG reaction" xref: METACYC:RXN0-1461 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18260 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC03263 {cardinality="1"} ! coproporphyrinogen-III relationship: has_input_compound UPa:UPC03263 ! coproporphyrinogen-III relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC01079 {cardinality="1"} ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC01079 ! protoporphyrinogen-IX relationship: part_of UPa:UER00322 ! protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1 relationship: part_of UPa:UER00322 {cardinality="1", direction="LR", order="1"} ! protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1 [Term] id: UPa:UCR03222 name: 3 O(2) + protoporphyrinogen-IX = 3 H(2)O(2) + protoporphyrin-IX namespace: reaction xref: KEGG:R03222 "KEGG reaction" xref: METACYC:PROTOPORGENOXI-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25579 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC01079 {cardinality="1"} ! protoporphyrinogen-IX relationship: has_input_compound UPa:UPC01079 ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC02191 ! protoporphyrin-IX relationship: has_output_compound UPa:UPC02191 {cardinality="1"} ! protoporphyrin-IX relationship: part_of UPa:UER00324 {cardinality="1", direction="LR", order="1"} ! protoporphyrin-IX from protoporphyrinogen-IX: step 1/1 relationship: part_of UPa:UER00324 ! protoporphyrin-IX from protoporphyrinogen-IX: step 1/1 [Term] id: UPa:UCR03223 name: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole = diphosphate + thiamine phosphate namespace: reaction xref: KEGG:R03223 "KEGG reaction" xref: METACYC:THI-P-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22331 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04327 ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_input_compound UPa:UPC04327 {cardinality="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_input_compound UPa:UPC04752 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: has_input_compound UPa:UPC04752 {cardinality="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC01081 {cardinality="1"} ! thiamine phosphate relationship: has_output_compound UPa:UPC01081 ! thiamine phosphate relationship: part_of UPa:UER00141 {cardinality="1", direction="LR", order="1"} ! thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1 relationship: part_of UPa:UER00141 ! thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1 [Term] id: UPa:UCR03230 name: acetyl-CoA + deacetylvindoline = CoA + vindoline namespace: reaction xref: KEGG:R03230 "KEGG reaction" xref: METACYC:2.3.1.107-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24499 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC01091 ! deacetylvindoline relationship: has_input_compound UPa:UPC01091 {cardinality="1"} ! deacetylvindoline relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC01626 ! vindoline relationship: has_output_compound UPa:UPC01626 {cardinality="1"} ! vindoline relationship: part_of UPa:UER00526 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 6/6 relationship: part_of UPa:UER00526 ! vindoline from tabersonine: step 6/6 [Term] id: UPa:UCR03231 name: 8-amino-7-oxononanoate + S-adenosyl-L-methionine = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoic acid namespace: reaction xref: KEGG:R03231 "KEGG reaction" xref: METACYC:DAPASYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16864 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01092 ! 8-amino-7-oxononanoate relationship: has_input_compound UPa:UPC01092 {cardinality="1"} ! 8-amino-7-oxononanoate relationship: has_output_compound UPa:UPC01037 ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC01037 {cardinality="1"} ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC04425 ! S-adenosyl-4-methylthio-2-oxobutanoic acid relationship: has_output_compound UPa:UPC04425 {cardinality="1"} ! S-adenosyl-4-methylthio-2-oxobutanoic acid relationship: part_of UPa:UER00160 ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1 relationship: part_of UPa:UER00160 {cardinality="1", direction="LR", order="1"} ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1 [Term] id: UPa:UCR03236 name: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate namespace: reaction xref: KEGG:R03236 "KEGG reaction" xref: METACYC:TAGAKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12423 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01097 ! D-tagatose 6-phosphate relationship: has_input_compound UPa:UPC01097 {cardinality="1"} ! D-tagatose 6-phosphate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC03785 {cardinality="1"} ! D-tagatose 1,6-bisphosphate relationship: has_output_compound UPa:UPC03785 ! D-tagatose 1,6-bisphosphate relationship: part_of UPa:UER00715 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2 relationship: part_of UPa:UER00715 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2 [Term] id: UPa:UCR03240 name: D-galactose 6-phosphate = D-tagatose 6-phosphate namespace: reaction xref: KEGG:R03240 "KEGG reaction" xref: METACYC:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13036 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01113 {cardinality="1"} ! D-galactose 6-phosphate relationship: has_input_compound UPa:UPC01113 ! D-galactose 6-phosphate relationship: has_output_compound UPa:UPC01097 {cardinality="1"} ! D-tagatose 6-phosphate relationship: has_output_compound UPa:UPC01097 ! D-tagatose 6-phosphate relationship: part_of UPa:UER00714 {cardinality="1", direction="LR", order="1"} ! D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1 relationship: part_of UPa:UER00714 ! D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1 [Term] id: UPa:UCR03241 name: ATP + L-fuculose = ADP + L-fuculose 1-phosphate namespace: reaction xref: KEGG:R03241 "KEGG reaction" xref: METACYC:FUCULOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12379 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01721 {cardinality="1"} ! L-fuculose relationship: has_input_compound UPa:UPC01721 ! L-fuculose relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC01099 {cardinality="1"} ! L-fuculose 1-phosphate relationship: has_output_compound UPa:UPC01099 ! L-fuculose 1-phosphate relationship: part_of UPa:UER00625 {cardinality="1", direction="LR", order="1"} ! L-lactaldehyde and glycerone phosphate from L-fucose: step 2/3 relationship: part_of UPa:UER00625 ! L-lactaldehyde and glycerone phosphate from L-fucose: step 2/3 [Term] id: UPa:UCR03243 name: 2-oxoglutarate + L-histidinol phosphate = L-glutamate + imidazole-acetol phosphate namespace: reaction xref: KEGG:R03243 "KEGG reaction" xref: METACYC:HISTAMINOTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23747 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC01100 ! L-histidinol phosphate relationship: has_input_compound UPa:UPC01100 {cardinality="1"} ! L-histidinol phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC01267 {cardinality="1"} ! imidazole-acetol phosphate relationship: has_output_compound UPa:UPC01267 ! imidazole-acetol phosphate relationship: part_of UPa:UER00012 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9 relationship: part_of UPa:UER00012 {cardinality="1", direction="RL", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9 [Term] id: UPa:UCR03244 name: L-ribulose 5-phosphate = L-xylulose 5-phosphate namespace: reaction xref: KEGG:R03244 "KEGG reaction" xref: METACYC:LXULRU5P-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18500 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01101 ! L-ribulose 5-phosphate relationship: has_input_compound UPa:UPC01101 {cardinality="1"} ! L-ribulose 5-phosphate relationship: has_output_compound UPa:UPC03291 ! L-xylulose 5-phosphate relationship: has_output_compound UPa:UPC03291 {cardinality="1"} ! L-xylulose 5-phosphate relationship: part_of UPa:UER00379 ! D-xylulose 5-phosphate from L-ascorbate: step 3/4 relationship: part_of UPa:UER00379 {cardinality="1", direction="RL", order="1"} ! D-xylulose 5-phosphate from L-ascorbate: step 3/4 [Term] id: UPa:UCR03245 name: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP namespace: reaction xref: KEGG:R03245 "KEGG reaction" xref: METACYC:PHOSPHOMEVALONATE-KINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16344 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01107 {cardinality="1"} ! (R)-5-phosphomevalonate relationship: has_input_compound UPa:UPC01107 ! (R)-5-phosphomevalonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC01143 ! (R)-5-diphosphomevalonate relationship: has_output_compound UPa:UPC01143 {cardinality="1"} ! (R)-5-diphosphomevalonate relationship: part_of UPa:UER00099 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from (R)-mevalonate: step 2/3 relationship: part_of UPa:UER00099 ! isopentenyl diphosphate from (R)-mevalonate: step 2/3 [Term] id: UPa:UCR03254 name: 8-phospho-3-deoxy-D-manno-octulosonate + phosphate = D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate namespace: reaction xref: KEGG:R03254 "KEGG reaction" xref: METACYC:KDO-8PSYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14056 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC04478 ! 8-phospho-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC04478 {cardinality="1"} ! 8-phospho-3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_output_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: has_output_compound UPa:UPC01112 {cardinality="1"} ! D-arabinose 5-phosphate relationship: has_output_compound UPa:UPC01112 ! D-arabinose 5-phosphate relationship: part_of UPa:UER00474 {cardinality="1", direction="RL", order="1"} ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3 relationship: part_of UPa:UER00474 ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3 [Term] id: UPa:UCR03256 name: H(2)O + lactose 6-phosphate = D-galactose 6-phosphate + beta-D-glucose namespace: reaction xref: KEGG:R03256 "KEGG reaction" xref: METACYC:LACTOSE6P-HYDROXY-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42407 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC05396 ! lactose 6-phosphate relationship: has_input_compound UPa:UPC05396 {cardinality="1"} ! lactose 6-phosphate relationship: has_output_compound UPa:UPC00221 ! beta-D-glucose relationship: has_output_compound UPa:UPC00221 {cardinality="1"} ! beta-D-glucose relationship: has_output_compound UPa:UPC01113 {cardinality="1"} ! D-galactose 6-phosphate relationship: has_output_compound UPa:UPC01113 ! D-galactose 6-phosphate relationship: part_of UPa:UER00605 {cardinality="1", direction="LR", order="1"} ! D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1 relationship: part_of UPa:UER00605 ! D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1 [Term] id: UPa:UCR03260 name: L-cysteine + O-succinyl-L-homoserine = L-cystathionine + succinate namespace: reaction xref: KEGG:R03260 "KEGG reaction" xref: METACYC:O-SUCCHOMOSERLYASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20400 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC01118 ! O-succinyl-L-homoserine relationship: has_input_compound UPa:UPC01118 {cardinality="1"} ! O-succinyl-L-homoserine relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: has_output_compound UPa:UPC02291 ! L-cystathionine relationship: part_of UPa:UER00077 {cardinality="1", direction="LR", order="1"} ! L-cystathionine from O-succinyl-L-homoserine: step 1/1 relationship: part_of UPa:UER00077 ! L-cystathionine from O-succinyl-L-homoserine: step 1/1 [Term] id: UPa:UCR03269 name: N-[(R)-4-phosphonopantothenoyl]-L-cysteine = CO(2) + pantotheine 4'-phosphate namespace: reaction xref: KEGG:R03269 "KEGG reaction" xref: METACYC:P-PANTOCYSDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16796 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04352 ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine relationship: has_input_compound UPa:UPC04352 {cardinality="1"} ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC01134 ! pantotheine 4'-phosphate relationship: has_output_compound UPa:UPC01134 {cardinality="1"} ! pantotheine 4'-phosphate relationship: part_of UPa:UER00354 ! CoA from (R)-pantothenate: step 3/5 relationship: part_of UPa:UER00354 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 3/5 [Term] id: UPa:UCR03298 name: 2,3-bisphospho-D-glycerate + ATP = ADP + cyclic 2,3-diphosphoglycerate + phosphate namespace: reaction xref: KEGG:R03298 "KEGG reaction" xref: RHEA:42415 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01159 ! 2,3-bisphospho-D-glycerate relationship: has_input_compound UPa:UPC01159 {cardinality="1"} ! 2,3-bisphospho-D-glycerate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC06189 ! cyclic 2,3-diphosphoglycerate relationship: has_output_compound UPa:UPC06189 {cardinality="1"} ! cyclic 2,3-diphosphoglycerate relationship: part_of UPa:UER00610 {cardinality="1", direction="LR", order="1"} ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 2/2 relationship: part_of UPa:UER00610 ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 2/2 [Term] id: UPa:UCR03303 name: (3,4-dihydroxyphenyl)acetate + O(2) = 5-carboxymethyl-2-hydroxymuconate semialdehyde namespace: reaction xref: KEGG:R03303 "KEGG reaction" xref: METACYC:1.13.11.15-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15636 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC01161 ! (3,4-dihydroxyphenyl)acetate relationship: has_input_compound UPa:UPC01161 {cardinality="1"} ! (3,4-dihydroxyphenyl)acetate relationship: has_output_compound UPa:UPC04642 ! 5-carboxymethyl-2-hydroxymuconate semialdehyde relationship: has_output_compound UPa:UPC04642 {cardinality="1"} ! 5-carboxymethyl-2-hydroxymuconate semialdehyde relationship: part_of UPa:UER00417 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 2/7 relationship: part_of UPa:UER00417 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 2/7 [Term] id: UPa:UCR03307 name: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate namespace: reaction xref: KEGG:R03307 "KEGG reaction" xref: METACYC:5.5.1.2-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23659 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01278 ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_input_compound UPa:UPC01278 {cardinality="1"} ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_output_compound UPa:UPC01163 {cardinality="1"} ! 3-carboxy-cis,cis-muconate relationship: has_output_compound UPa:UPC01163 ! 3-carboxy-cis,cis-muconate relationship: part_of UPa:UER00265 {cardinality="1", direction="RL", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 1/2 relationship: part_of UPa:UER00265 ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 1/2 [Term] id: UPa:UCR03308 name: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate namespace: reaction xref: KEGG:R03308 "KEGG reaction" xref: METACYC:CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14980 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04553 ! 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_input_compound UPa:UPC04553 {cardinality="1"} ! 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_output_compound UPa:UPC01163 {cardinality="1"} ! 3-carboxy-cis,cis-muconate relationship: has_output_compound UPa:UPC01163 ! 3-carboxy-cis,cis-muconate relationship: part_of UPa:UER00308 {cardinality="1", direction="LR", order="1"} ! 3-carboxy-cis,cis-muconate from 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate: step 1/1 relationship: part_of UPa:UER00308 ! 3-carboxy-cis,cis-muconate from 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate: step 1/1 [Term] id: UPa:UCR03313 name: L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH namespace: reaction xref: KEGG:R03313 "KEGG reaction" xref: METACYC:GLUTSEMIALDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19544 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC01165 {cardinality="1"} ! L-glutamate 5-semialdehyde relationship: has_input_compound UPa:UPC01165 ! L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03287 {cardinality="1"} ! L-glutamyl 5-phosphate relationship: has_output_compound UPa:UPC03287 ! L-glutamyl 5-phosphate relationship: part_of UPa:UER00360 ! L-glutamate 5-semialdehyde from L-glutamate: step 2/2 relationship: part_of UPa:UER00360 {cardinality="1", direction="RL", order="1"} ! L-glutamate 5-semialdehyde from L-glutamate: step 2/2 [Term] id: UPa:UCR03314 name: L-glutamate 5-semialdehyde = (S)-1-pyrroline-5-carboxylic acid + H(2)O namespace: reaction xref: KEGG:R03314 "KEGG reaction" xref: METACYC:SPONTPRO-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:28237 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01165 ! L-glutamate 5-semialdehyde relationship: has_input_compound UPa:UPC01165 {cardinality="1"} ! L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC03912 {cardinality="1"} ! (S)-1-pyrroline-5-carboxylic acid relationship: has_output_compound UPa:UPC03912 ! (S)-1-pyrroline-5-carboxylic acid relationship: part_of UPa:UER00361 ! L-proline from L-glutamate 5-semialdehyde: step 1/1 relationship: part_of UPa:UER00361 {cardinality="1", direction="LR", order="1"} ! L-proline from L-glutamate 5-semialdehyde: step 1/1 [Term] id: UPa:UCR03348 name: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + quinolinate namespace: reaction xref: KEGG:R03348 "KEGG reaction" xref: METACYC:QUINOPRIBOTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12736 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC01185 ! nicotinate D-ribonucleotide relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC03722 ! quinolinate relationship: has_output_compound UPa:UPC03722 {cardinality="1"} ! quinolinate relationship: part_of UPa:UER00331 {cardinality="1", direction="RL", order="1"} ! nicotinate D-ribonucleotide from quinolinate: step 1/1 relationship: part_of UPa:UER00331 ! nicotinate D-ribonucleotide from quinolinate: step 1/1 [Term] id: UPa:UCR03350 name: 8-phospho-3-deoxy-D-manno-octulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate namespace: reaction xref: KEGG:R03350 "KEGG reaction" xref: METACYC:KDO-8PPHOSPHAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11503 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04478 ! 8-phospho-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC04478 {cardinality="1"} ! 8-phospho-3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC01187 {cardinality="1"} ! 3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC01187 ! 3-deoxy-D-manno-octulosonate relationship: part_of UPa:UER00475 {cardinality="1", direction="LR", order="1"} ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 3/3 relationship: part_of UPa:UER00475 ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 3/3 [Term] id: UPa:UCR03351 name: 3-deoxy-D-manno-octulosonate + CTP = CMP-3-deoxy-D-manno-octulosonate + diphosphate namespace: reaction xref: KEGG:R03351 "KEGG reaction" xref: METACYC:CPM-KDOSYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23451 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC01187 {cardinality="1"} ! 3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC01187 ! 3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC04121 ! CMP-3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC04121 {cardinality="1"} ! CMP-3-deoxy-D-manno-octulosonate relationship: part_of UPa:UER00476 ! CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1 relationship: part_of UPa:UER00476 {cardinality="1", direction="LR", order="1"} ! CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1 [Term] id: UPa:UCR03387 name: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonic acid + ADP namespace: reaction xref: KEGG:R03387 "KEGG reaction" xref: METACYC:DEHYDDEOXGALACTKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16528 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01216 ! 2-dehydro-3-deoxy-D-galactonate relationship: has_input_compound UPa:UPC01216 {cardinality="1"} ! 2-dehydro-3-deoxy-D-galactonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC01286 {cardinality="1"} ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid relationship: has_output_compound UPa:UPC01286 ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid relationship: part_of UPa:UER00519 ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 2/3 relationship: part_of UPa:UER00519 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 2/3 [Term] id: UPa:UCR03390 name: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran namespace: reaction xref: KEGG:R03390 "KEGG reaction" xref: METACYC:2.3.1.101-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18064 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01001 ! N-formylmethanofuran relationship: has_input_compound UPa:UPC01001 {cardinality="1"} ! N-formylmethanofuran relationship: has_input_compound UPa:UPC01217 {cardinality="1"} ! 5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC01217 ! 5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00862 {cardinality="1"} ! methanofuran relationship: has_output_compound UPa:UPC00862 ! methanofuran relationship: has_output_compound UPa:UPC01274 ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01274 {cardinality="1"} ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00693 {cardinality="1", direction="LR", order="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3 relationship: part_of UPa:UER00693 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3 relationship: part_of UPa:UER00704 ! formate from formaldehyde (H(4)MPT route): step 4/5 relationship: part_of UPa:UER00704 {cardinality="1", direction="RL", order="1"} ! formate from formaldehyde (H(4)MPT route): step 4/5 [Term] id: UPa:UCR03391 name: CDP-4-dehydro-3,6-dideoxy-D-glucose + H(2)O + NAD(+) = CDP-4-dehydro-6-deoxy-D-glucose + H(+) + NADH namespace: reaction xref: KEGG:R03391 "KEGG reaction" xref: RHEA:19656 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC04297 ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: has_input_compound UPa:UPC04297 {cardinality="1"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01219 ! CDP-4-dehydro-6-deoxy-D-glucose relationship: has_output_compound UPa:UPC01219 {cardinality="1"} ! CDP-4-dehydro-6-deoxy-D-glucose relationship: part_of UPa:UER00967 ! None relationship: part_of UPa:UER00967 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR03392 name: CDP-4-dehydro-3,6-dideoxy-D-glucose + H(2)O + NADP(+) = CDP-4-dehydro-6-deoxy-D-glucose + H(+) + NADPH namespace: reaction xref: KEGG:R03392 "KEGG reaction" xref: METACYC:1.17.1.1-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19660 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC04297 ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: has_input_compound UPa:UPC04297 {cardinality="1"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01219 ! CDP-4-dehydro-6-deoxy-D-glucose relationship: has_output_compound UPa:UPC01219 {cardinality="1"} ! CDP-4-dehydro-6-deoxy-D-glucose relationship: part_of UPa:UER00968 ! None relationship: part_of UPa:UER00968 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR03409 name: H(2)O + guanosine 3'-diphosphate 5'-triphosphate = phosphate + ppGpp namespace: reaction xref: KEGG:R03409 "KEGG reaction" xref: METACYC:PPPGPPHYDRO-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13076 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04494 ! guanosine 3'-diphosphate 5'-triphosphate relationship: has_input_compound UPa:UPC04494 {cardinality="1"} ! guanosine 3'-diphosphate 5'-triphosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC01228 ! ppGpp relationship: has_output_compound UPa:UPC01228 {cardinality="1"} ! ppGpp relationship: part_of UPa:UER00885 ! ppGpp from GTP: step 2/2 relationship: part_of UPa:UER00885 {cardinality="1", direction="LR", order="1"} ! ppGpp from GTP: step 2/2 [Term] id: UPa:UCR03418 name: 1-alpha-D-galactosyl-myo-inositol + raffinose = myo-inositol + stachyose namespace: reaction xref: KEGG:R03418 "KEGG reaction" xref: METACYC:2.4.1.67-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20779 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00492 ! raffinose relationship: has_input_compound UPa:UPC00492 {cardinality="1"} ! raffinose relationship: has_input_compound UPa:UPC01235 ! 1-alpha-D-galactosyl-myo-inositol relationship: has_input_compound UPa:UPC01235 {cardinality="1"} ! 1-alpha-D-galactosyl-myo-inositol relationship: has_output_compound UPa:UPC00137 ! myo-inositol relationship: has_output_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol relationship: has_output_compound UPa:UPC01613 ! stachyose relationship: has_output_compound UPa:UPC01613 {cardinality="1"} ! stachyose relationship: part_of UPa:UER00892 {cardinality="1", direction="LR", order="1"} ! stachyose from raffinose: step 1/1 relationship: part_of UPa:UER00892 ! stachyose from raffinose: step 1/1 [Term] id: UPa:UCR03443 name: N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH namespace: reaction xref: KEGG:R03443 "KEGG reaction" xref: METACYC:N-ACETYLGLUTPREDUCT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21591 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC01250 {cardinality="1"} ! N-acetyl-L-glutamate 5-semialdehyde relationship: has_input_compound UPa:UPC01250 ! N-acetyl-L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC04133 {cardinality="1"} ! N-acetyl-L-glutamyl 5-phosphate relationship: has_output_compound UPa:UPC04133 ! N-acetyl-L-glutamyl 5-phosphate relationship: part_of UPa:UER00108 {cardinality="1", direction="RL", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate: step 3/4 relationship: part_of UPa:UER00108 ! N(2)-acetyl-L-ornithine from L-glutamate: step 3/4 [Term] id: UPa:UCR03444 name: (R)-homocitrate = H(2)O + homo-cis-aconitate namespace: reaction xref: KEGG:R03444 "KEGG reaction" xref: METACYC:RXN3O-1983 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26104 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01251 {cardinality="1"} ! (R)-homocitrate relationship: has_input_compound UPa:UPC01251 ! (R)-homocitrate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC04002 ! homo-cis-aconitate relationship: has_output_compound UPa:UPC04002 {cardinality="1"} ! homo-cis-aconitate relationship: part_of UPa:UER00029 {cardinality="1", direction="LR", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 2/5 relationship: part_of UPa:UER00029 ! L-alpha-aminoadipate from 2-oxoglutarate: step 2/5 [Term] id: UPa:UCR03445 name: 4-(2-aminophenyl)-2,4-dioxobutanoate = H(2)O + kynurenate namespace: reaction xref: KEGG:R03445 "KEGG reaction" xref: METACYC:RXN-10720 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42455 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01252 {cardinality="1"} ! 4-(2-aminophenyl)-2,4-dioxobutanoate relationship: has_input_compound UPa:UPC01252 ! 4-(2-aminophenyl)-2,4-dioxobutanoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC01717 ! kynurenate relationship: has_output_compound UPa:UPC01717 {cardinality="1"} ! kynurenate relationship: part_of UPa:UER00727 {cardinality="1", direction="LR", order="1"} ! kynurenate from L-kynurenine: step 2/2 relationship: part_of UPa:UER00727 ! kynurenate from L-kynurenine: step 2/2 [Term] id: UPa:UCR03457 name: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = H(2)O + imidazole-acetol phosphate namespace: reaction xref: KEGG:R03457 "KEGG reaction" xref: METACYC:IMIDPHOSDEHYD-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11043 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04666 ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_input_compound UPa:UPC04666 {cardinality="1"} ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01267 {cardinality="1"} ! imidazole-acetol phosphate relationship: has_output_compound UPa:UPC01267 ! imidazole-acetol phosphate relationship: part_of UPa:UER00011 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9 relationship: part_of UPa:UER00011 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9 [Term] id: UPa:UCR03458 name: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH namespace: reaction xref: KEGG:R03458 "KEGG reaction" xref: METACYC:RIBOFLAVINSYNREDUC-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17848 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC04454 ! 5-amino-6-(5-phosphoribitylamino)uracil relationship: has_input_compound UPa:UPC04454 {cardinality="1"} ! 5-amino-6-(5-phosphoribitylamino)uracil relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01268 ! 5-amino-6-(5-phosphoribosylamino)uracil relationship: has_output_compound UPa:UPC01268 {cardinality="1"} ! 5-amino-6-(5-phosphoribosylamino)uracil relationship: part_of UPa:UER00402 ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4 relationship: part_of UPa:UER00402 {cardinality="1", direction="RL", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4 [Term] id: UPa:UCR03459 name: 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5-phosphoribosylamino)uracil + NH(3) namespace: reaction xref: KEGG:R03459 "KEGG reaction" xref: METACYC:RIBOFLAVINSYNDEAM-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21871 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01304 {cardinality="1"} ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine relationship: has_input_compound UPa:UPC01304 ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC01268 ! 5-amino-6-(5-phosphoribosylamino)uracil relationship: has_output_compound UPa:UPC01268 {cardinality="1"} ! 5-amino-6-(5-phosphoribosylamino)uracil relationship: part_of UPa:UER00401 {cardinality="1", direction="LR", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4 relationship: part_of UPa:UER00401 ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4 [Term] id: UPa:UCR03460 name: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate namespace: reaction xref: KEGG:R03460 "KEGG reaction" xref: METACYC:2.5.1.19-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21259 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC03175 ! 3-phosphoshikimate relationship: has_input_compound UPa:UPC03175 {cardinality="1"} ! 3-phosphoshikimate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC01269 {cardinality="1"} ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate relationship: has_output_compound UPa:UPC01269 ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate relationship: part_of UPa:UER00089 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7 relationship: part_of UPa:UER00089 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7 [Term] id: UPa:UCR03462 name: O(2) + biphenyl-2,3-diol = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate namespace: reaction xref: KEGG:R03462 "KEGG reaction" xref: METACYC:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14416 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC02526 ! biphenyl-2,3-diol relationship: has_input_compound UPa:UPC02526 {cardinality="1"} ! biphenyl-2,3-diol relationship: has_output_compound UPa:UPC01273 {cardinality="1"} ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate relationship: has_output_compound UPa:UPC01273 ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate relationship: part_of UPa:UER00252 ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 3/4 relationship: part_of UPa:UER00252 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 3/4 [Term] id: UPa:UCR03464 name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin namespace: reaction xref: KEGG:R03464 "KEGG reaction" xref: METACYC:3.5.4.27-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19056 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC01274 {cardinality="1"} ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01274 ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00694 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3 relationship: part_of UPa:UER00694 {cardinality="1", direction="RL", order="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3 relationship: part_of UPa:UER00703 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (H(4)MPT route): step 3/5 relationship: part_of UPa:UER00703 ! formate from formaldehyde (H(4)MPT route): step 3/5 [Term] id: UPa:UCR03470 name: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 5-oxo-4,5-dihydro-2-furylacetate + CO(2) namespace: reaction xref: KEGG:R03470 "KEGG reaction" xref: METACYC:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23351 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01278 {cardinality="1"} ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_input_compound UPa:UPC01278 ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC03586 {cardinality="1"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_output_compound UPa:UPC03586 ! 5-oxo-4,5-dihydro-2-furylacetate relationship: part_of UPa:UER00266 ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 2/2 relationship: part_of UPa:UER00266 {cardinality="1", direction="LR", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 2/2 [Term] id: UPa:UCR03471 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP namespace: reaction xref: KEGG:R03471 "KEGG reaction" xref: METACYC:OHMETPYRKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23099 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01279 {cardinality="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_input_compound UPa:UPC01279 ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04556 {cardinality="1"} ! 4-amino-2-methyl-5-phosphomethylpyrimidine relationship: has_output_compound UPa:UPC04556 ! 4-amino-2-methyl-5-phosphomethylpyrimidine relationship: part_of UPa:UER00137 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3 relationship: part_of UPa:UER00137 {cardinality="1", direction="LR", order="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3 [Term] id: UPa:UCR03503 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + AMP namespace: reaction xref: KEGG:R03503 "KEGG reaction" xref: METACYC:H2PTERIDINEPYROPHOSPHOKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11415 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01300 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine relationship: has_input_compound UPa:UPC01300 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC04807 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: has_output_compound UPa:UPC04807 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: part_of UPa:UER00155 {cardinality="1", direction="LR", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4 relationship: part_of UPa:UER00155 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4 [Term] id: UPa:UCR03504 name: 7,8-dihydroneopterin = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde namespace: reaction xref: KEGG:R03504 "KEGG reaction" xref: METACYC:H2NEOPTERINALDOL-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10543 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04874 {cardinality="1"} ! 7,8-dihydroneopterin relationship: has_input_compound UPa:UPC04874 ! 7,8-dihydroneopterin relationship: has_output_compound UPa:UPC00266 ! glycolaldehyde relationship: has_output_compound UPa:UPC00266 {cardinality="1"} ! glycolaldehyde relationship: has_output_compound UPa:UPC01300 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine relationship: has_output_compound UPa:UPC01300 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine relationship: part_of UPa:UER00154 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4 relationship: part_of UPa:UER00154 {cardinality="1", direction="LR", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4 [Term] id: UPa:UCR03508 name: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = CO(2) + H(2)O + indoleglycerol phosphate namespace: reaction xref: KEGG:R03508 "KEGG reaction" xref: METACYC:IGPSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23479 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01302 ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC01302 {cardinality="1"} ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC03506 {cardinality="1"} ! indoleglycerol phosphate relationship: has_output_compound UPa:UPC03506 ! indoleglycerol phosphate relationship: part_of UPa:UER00043 {cardinality="1", direction="LR", order="1"} ! L-tryptophan from chorismate: step 4/5 relationship: part_of UPa:UER00043 ! L-tryptophan from chorismate: step 4/5 [Term] id: UPa:UCR03509 name: N-(5-phospho-beta-D-ribosyl)anthranilic acid = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate namespace: reaction xref: KEGG:R03509 "KEGG reaction" xref: METACYC:PRAISOM-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21543 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04302 {cardinality="1"} ! N-(5-phospho-beta-D-ribosyl)anthranilic acid relationship: has_input_compound UPa:UPC04302 ! N-(5-phospho-beta-D-ribosyl)anthranilic acid relationship: has_output_compound UPa:UPC01302 {cardinality="1"} ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC01302 ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate relationship: part_of UPa:UER00042 {cardinality="1", direction="LR", order="1"} ! L-tryptophan from chorismate: step 3/5 relationship: part_of UPa:UER00042 ! L-tryptophan from chorismate: step 3/5 [Term] id: UPa:UCR03534 name: 2-hydroxyglutarate + FAD = 2-oxoglutarate + FADH2 namespace: reaction xref: KEGG:R03534 "KEGG reaction" xref: METACYC:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:21255 "Rhea reaction" xref: RHEA:25264 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00016 ! FAD relationship: has_input_compound UPa:UPC00016 {cardinality="1"} ! FAD relationship: has_input_compound UPa:UPC02630 ! 2-hydroxyglutarate relationship: has_input_compound UPa:UPC02630 {cardinality="1"} ! 2-hydroxyglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC01352 ! FADH2 relationship: has_output_compound UPa:UPC01352 {cardinality="1"} ! FADH2 relationship: part_of UPa:UER00685 ! crotonoyl-CoA from L-glutamate: step 2/5 relationship: part_of UPa:UER00685 {cardinality="1", direction="RL", order="1"} ! crotonoyl-CoA from L-glutamate: step 2/5 [Term] id: UPa:UCR03543 name: H(+) + NADH + O(2) + benzene = NAD(+) + cis-1,2-dihydrobenzene-1,2-diol namespace: reaction xref: KEGG:R03543 "KEGG reaction" xref: METACYC:BENZENE-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13816 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC01407 {cardinality="1"} ! benzene relationship: has_input_compound UPa:UPC01407 ! benzene relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC04091 {cardinality="1"} ! cis-1,2-dihydrobenzene-1,2-diol relationship: has_output_compound UPa:UPC04091 ! cis-1,2-dihydrobenzene-1,2-diol relationship: part_of UPa:UER00391 ! catechol from benzene: step 1/2 relationship: part_of UPa:UER00391 {cardinality="1", direction="LR", order="1"} ! catechol from benzene: step 1/2 [Term] id: UPa:UCR03559 name: H(+) + NADH + O(2) + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) namespace: reaction xref: KEGG:R03559 "KEGG reaction" xref: METACYC:TOLUENE-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16740 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC01455 ! toluene relationship: has_input_compound UPa:UPC01455 {cardinality="1"} ! toluene relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC04592 ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol relationship: has_output_compound UPa:UPC04592 {cardinality="1"} ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol relationship: part_of UPa:UER00393 {cardinality="1", direction="LR", order="1"} ! 3-methylcatechol from toluene: step 1/2 relationship: part_of UPa:UER00393 ! 3-methylcatechol from toluene: step 1/2 [Term] id: UPa:UCR03630 name: H(+) + NADH + O(2) + phthalate = NAD(+) + cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid namespace: reaction xref: KEGG:R03630 "KEGG reaction" xref: METACYC:PHTHALATE-45-DIOXYGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17492 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC01606 {cardinality="1"} ! phthalate relationship: has_input_compound UPa:UPC01606 ! phthalate relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC04783 ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid relationship: has_output_compound UPa:UPC04783 {cardinality="1"} ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid relationship: part_of UPa:UER00728 ! 3,4-dihydroxybenzoate from phthalate: step 1/3 relationship: part_of UPa:UER00728 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from phthalate: step 1/3 [Term] id: UPa:UCR03693 name: L-citramalate = H(2)O + mesaconate namespace: reaction xref: KEGG:R03693 "KEGG reaction" xref: METACYC:S-2-METHYLMALATE-DEHYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13532 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02614 ! L-citramalate relationship: has_input_compound UPa:UPC02614 {cardinality="1"} ! L-citramalate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01732 {cardinality="1"} ! mesaconate relationship: has_output_compound UPa:UPC01732 ! mesaconate relationship: part_of UPa:UER00619 {cardinality="1", direction="RL", order="1"} ! acetate and pyruvate from L-glutamate: step 3/4 relationship: part_of UPa:UER00619 ! acetate and pyruvate from L-glutamate: step 3/4 [Term] id: UPa:UCR03696 name: (2S,3S)-3-methyl-L-aspartate = NH(3) + mesaconate namespace: reaction xref: KEGG:R03696 "KEGG reaction" xref: METACYC:METHYLASPARTATE-AMMONIA-LYASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12832 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03618 ! (2S,3S)-3-methyl-L-aspartate relationship: has_input_compound UPa:UPC03618 {cardinality="1"} ! (2S,3S)-3-methyl-L-aspartate relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC01732 {cardinality="1"} ! mesaconate relationship: has_output_compound UPa:UPC01732 ! mesaconate relationship: part_of UPa:UER00618 ! acetate and pyruvate from L-glutamate: step 2/4 relationship: part_of UPa:UER00618 {cardinality="1", direction="LR", order="1"} ! acetate and pyruvate from L-glutamate: step 2/4 [Term] id: UPa:UCR03721 name: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine namespace: reaction xref: KEGG:R03721 "KEGG reaction" xref: METACYC:2.1.1.118-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15376 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01795 ! columbamine relationship: has_input_compound UPa:UPC01795 {cardinality="1"} ! columbamine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC05315 ! palmatine relationship: has_output_compound UPa:UPC05315 {cardinality="1"} ! palmatine relationship: part_of UPa:UER00445 {cardinality="1", direction="LR", order="1"} ! palmatine from columbamine: step 1/1 relationship: part_of UPa:UER00445 ! palmatine from columbamine: step 1/1 [Term] id: UPa:UCR03738 name: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine namespace: reaction xref: KEGG:R03738 "KEGG reaction" xref: METACYC:STRICTOSIDINE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15016 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC03470 {cardinality="1"} ! 3alpha(S)-strictosidine relationship: has_input_compound UPa:UPC03470 ! 3alpha(S)-strictosidine relationship: has_output_compound UPa:UPC00398 ! tryptamine relationship: has_output_compound UPa:UPC00398 {cardinality="1"} ! tryptamine relationship: has_output_compound UPa:UPC01852 {cardinality="1"} ! secologanin relationship: has_output_compound UPa:UPC01852 ! secologanin relationship: part_of UPa:UER00447 ! 3alpha(S)-strictosidine from secologanin and tryptamine: step 1/1 relationship: part_of UPa:UER00447 {cardinality="1", direction="RL", order="1"} ! 3alpha(S)-strictosidine from secologanin and tryptamine: step 1/1 [Term] id: UPa:UCR03791 name: (S)-mandelate = (R)-mandelate namespace: reaction xref: KEGG:R03791 "KEGG reaction" xref: METACYC:MANDELATE-RACEMASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13948 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01984 {cardinality="1"} ! (S)-mandelate relationship: has_input_compound UPa:UPC01984 ! (S)-mandelate relationship: has_output_compound UPa:UPC01983 {cardinality="1"} ! (R)-mandelate relationship: has_output_compound UPa:UPC01983 ! (R)-mandelate relationship: part_of UPa:UER00852 ! benzoate from (R)-mandelate: step 1/4 relationship: part_of UPa:UER00852 {cardinality="1", direction="RL", order="1"} ! benzoate from (R)-mandelate: step 1/4 [Term] id: UPa:UCR03793 name: (S)-mandelate + acceptor = phenylglyoxylate + reduced acceptor namespace: reaction xref: KEGG:R03793 "KEGG reaction" xref: METACYC:MANDELATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15752 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC01984 {cardinality="1"} ! (S)-mandelate relationship: has_input_compound UPa:UPC01984 ! (S)-mandelate relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC02137 ! phenylglyoxylate relationship: has_output_compound UPa:UPC02137 {cardinality="1"} ! phenylglyoxylate relationship: part_of UPa:UER00853 ! benzoate from (R)-mandelate: step 2/4 relationship: part_of UPa:UER00853 {cardinality="1", direction="LR", order="1"} ! benzoate from (R)-mandelate: step 2/4 [Term] id: UPa:UCR03831 name: (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2) namespace: reaction xref: KEGG:R03831 "KEGG reaction" xref: METACYC:RETICULINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19888 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC02105 ! (S)-reticuline relationship: has_input_compound UPa:UPC02105 {cardinality="1"} ! (S)-reticuline relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC02106 ! (S)-scoulerine relationship: has_output_compound UPa:UPC02106 {cardinality="1"} ! (S)-scoulerine relationship: part_of UPa:UER00450 ! (S)-scoulerine from (S)-reticuline: step 1/1 relationship: part_of UPa:UER00450 {cardinality="1", direction="LR", order="1"} ! (S)-scoulerine from (S)-reticuline: step 1/1 [Term] id: UPa:UCR03832 name: (S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine = (S)-reticuline + H(+) + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R03832 "KEGG reaction" xref: METACYC:2.1.1.116-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17792 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC05202 ! (S)-3'-hydroxy-N-methylcoclaurine relationship: has_input_compound UPa:UPC05202 {cardinality="1"} ! (S)-3'-hydroxy-N-methylcoclaurine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC02105 ! (S)-reticuline relationship: has_output_compound UPa:UPC02105 {cardinality="1"} ! (S)-reticuline relationship: part_of UPa:UER00444 {cardinality="1", direction="LR", order="1"} ! (S)-reticuline from (S)-norcoclaurine: step 4/4 relationship: part_of UPa:UER00444 ! (S)-reticuline from (S)-norcoclaurine: step 4/4 [Term] id: UPa:UCR03892 name: maleylacetate = 3-hydroxy-cis,cis-muconate namespace: reaction xref: KEGG:R03892 "KEGG reaction" xref: METACYC:RXN-9922 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42435 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02222 ! maleylacetate relationship: has_input_compound UPa:UPC02222 {cardinality="1"} ! maleylacetate relationship: has_output_compound UPa:UPC03676 {cardinality="1"} ! 3-hydroxy-cis,cis-muconate relationship: has_output_compound UPa:UPC03676 ! 3-hydroxy-cis,cis-muconate relationship: part_of UPa:UER00269 {cardinality="1", direction="RL", order="1"} ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 3/4 relationship: part_of UPa:UER00269 ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 3/4 [Term] id: UPa:UCR03896 name: (R)-citramalate = 2-methylmaleate + H(2)O namespace: reaction xref: KEGG:R03896 "KEGG reaction" xref: METACYC:R-2-METHYLMALATE-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22335 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02612 ! (R)-citramalate relationship: has_input_compound UPa:UPC02612 {cardinality="1"} ! (R)-citramalate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC02226 {cardinality="1"} ! 2-methylmaleate relationship: has_output_compound UPa:UPC02226 ! 2-methylmaleate relationship: part_of UPa:UER00067 ! 2-oxobutanoate from pyruvate: step 2/3 relationship: part_of UPa:UER00067 {cardinality="1", direction="LR", order="1"} ! 2-oxobutanoate from pyruvate: step 2/3 [Term] id: UPa:UCR03898 name: 2-methylmaleate + H(2)O = D-erythro-3-methylmalic acid namespace: reaction xref: KEGG:R03898 "KEGG reaction" xref: RHEA:42427 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02226 {cardinality="1"} ! 2-methylmaleate relationship: has_input_compound UPa:UPC02226 ! 2-methylmaleate relationship: has_output_compound UPa:UPC06032 ! D-erythro-3-methylmalic acid relationship: has_output_compound UPa:UPC06032 {cardinality="1"} ! D-erythro-3-methylmalic acid relationship: part_of UPa:UER00067 {cardinality="1", direction="LR", order="2"} ! 2-oxobutanoate from pyruvate: step 2/3 relationship: part_of UPa:UER00067 ! 2-oxobutanoate from pyruvate: step 2/3 [Term] id: UPa:UCR03908 name: 2-methyleneglutarate = 2-methylene-3-methylsuccinate namespace: reaction xref: KEGG:R03908 "KEGG reaction" xref: METACYC:2-METHYLENEGLUTARATE-MUTASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13796 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02930 {cardinality="1"} ! 2-methyleneglutarate relationship: has_input_compound UPa:UPC02930 ! 2-methyleneglutarate relationship: has_output_compound UPa:UPC02295 {cardinality="1"} ! 2-methylene-3-methylsuccinate relationship: has_output_compound UPa:UPC02295 ! 2-methylene-3-methylsuccinate relationship: part_of UPa:UER01016 ! propanoate and pyruvate from 6-hydroxynicotinate: step 5/8 relationship: part_of UPa:UER01016 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 5/8 [Term] id: UPa:UCR03932 name: 4-chlorobenzoate + ATP + CoA = 4-chlorobenzoyl-CoA + AMP + diphosphate namespace: reaction xref: KEGG:R03932 "KEGG reaction" xref: METACYC:6.2.1.33-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23223 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC02370 ! 4-chlorobenzoate relationship: has_input_compound UPa:UPC02370 {cardinality="1"} ! 4-chlorobenzoate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC06387 {cardinality="1"} ! 4-chlorobenzoyl-CoA relationship: has_output_compound UPa:UPC06387 ! 4-chlorobenzoyl-CoA relationship: part_of UPa:UER01020 {cardinality="1", direction="LR", order="1"} ! 4-hydroxybenzoate from 4-chlorobenzoate: step 1/3 relationship: part_of UPa:UER01020 ! 4-hydroxybenzoate from 4-chlorobenzoate: step 1/3 [Term] id: UPa:UCR03937 name: H(2)O + glutaconyl-1-CoA = 2-hydroxyglutaryl-CoA namespace: reaction xref: KEGG:R03937 "KEGG reaction" xref: METACYC:RXN-1083 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42451 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC02411 {cardinality="1"} ! glutaconyl-1-CoA relationship: has_input_compound UPa:UPC02411 ! glutaconyl-1-CoA relationship: has_output_compound UPa:UPC03058 ! 2-hydroxyglutaryl-CoA relationship: has_output_compound UPa:UPC03058 {cardinality="1"} ! 2-hydroxyglutaryl-CoA relationship: part_of UPa:UER00687 {cardinality="1", direction="RL", order="1"} ! crotonoyl-CoA from L-glutamate: step 4/5 relationship: part_of UPa:UER00687 ! crotonoyl-CoA from L-glutamate: step 4/5 [Term] id: UPa:UCR03947 name: NAD(+) + precorrin-2 = H(+) + NADH + sirohydrochlorin namespace: reaction xref: KEGG:R03947 "KEGG reaction" xref: METACYC:DIMETHUROPORDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15616 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC02463 ! precorrin-2 relationship: has_input_compound UPa:UPC02463 {cardinality="1"} ! precorrin-2 relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05778 ! sirohydrochlorin relationship: has_output_compound UPa:UPC05778 {cardinality="1"} ! sirohydrochlorin relationship: part_of UPa:UER00222 ! sirohydrochlorin from precorrin-2: step 1/1 relationship: part_of UPa:UER00222 {cardinality="1", direction="LR", order="1"} ! sirohydrochlorin from precorrin-2: step 1/1 [Term] id: UPa:UCR03948 name: S-adenosyl-L-methionine + precorrin-2 = H(+) + S-adenosyl-L-homocysteine + precorrin-3A namespace: reaction xref: KEGG:R03948 "KEGG reaction" xref: METACYC:2.1.1.130-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16844 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC02463 ! precorrin-2 relationship: has_input_compound UPa:UPC02463 {cardinality="1"} ! precorrin-2 relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05772 ! precorrin-3A relationship: has_output_compound UPa:UPC05772 {cardinality="1"} ! precorrin-3A relationship: part_of UPa:UER00212 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 1/10 relationship: part_of UPa:UER00212 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 1/10 [Term] id: UPa:UCR03968 name: (2S)-2-isopropylmalate = 2-isopropylmaleate + H(2)O namespace: reaction xref: KEGG:R03968 "KEGG reaction" xref: METACYC:3-ISOPROPYLMALISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16296 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02504 {cardinality="1"} ! (2S)-2-isopropylmalate relationship: has_input_compound UPa:UPC02504 ! (2S)-2-isopropylmalate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC02631 ! 2-isopropylmaleate relationship: has_output_compound UPa:UPC02631 {cardinality="1"} ! 2-isopropylmaleate relationship: part_of UPa:UER00071 {cardinality="1", direction="LR", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate: step 2/4 relationship: part_of UPa:UER00071 ! L-leucine from 3-methyl-2-oxobutanoate: step 2/4 [Term] id: UPa:UCR04000 name: 2-hydroxyglutarate + acetyl-CoA = 2-hydroxyglutaryl-CoA + acetate namespace: reaction xref: KEGG:R04000 "KEGG reaction" xref: METACYC:RXN-1082 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42079 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC02630 ! 2-hydroxyglutarate relationship: has_input_compound UPa:UPC02630 {cardinality="1"} ! 2-hydroxyglutarate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC03058 {cardinality="1"} ! 2-hydroxyglutaryl-CoA relationship: has_output_compound UPa:UPC03058 ! 2-hydroxyglutaryl-CoA relationship: part_of UPa:UER00686 {cardinality="1", direction="LR", order="1"} ! crotonoyl-CoA from L-glutamate: step 3/5 relationship: part_of UPa:UER00686 ! crotonoyl-CoA from L-glutamate: step 3/5 [Term] id: UPa:UCR04001 name: (2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H(2)O namespace: reaction xref: KEGG:R04001 "KEGG reaction" xref: METACYC:RXN-8991 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10679 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04411 ! (2R,3S)-3-isopropylmalate relationship: has_input_compound UPa:UPC04411 {cardinality="1"} ! (2R,3S)-3-isopropylmalate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC02631 ! 2-isopropylmaleate relationship: has_output_compound UPa:UPC02631 {cardinality="1"} ! 2-isopropylmaleate relationship: part_of UPa:UER00071 ! L-leucine from 3-methyl-2-oxobutanoate: step 2/4 relationship: part_of UPa:UER00071 {cardinality="1", direction="RL", order="2"} ! L-leucine from 3-methyl-2-oxobutanoate: step 2/4 [Term] id: UPa:UCR04013 name: 3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + desacetoxyvindoline namespace: reaction xref: KEGG:R04013 "KEGG reaction" xref: METACYC:2.1.1.99-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11339 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC04578 ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine relationship: has_input_compound UPa:UPC04578 {cardinality="1"} ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC02673 ! desacetoxyvindoline relationship: has_output_compound UPa:UPC02673 {cardinality="1"} ! desacetoxyvindoline relationship: part_of UPa:UER00524 ! vindoline from tabersonine: step 4/6 relationship: part_of UPa:UER00524 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 4/6 [Term] id: UPa:UCR04029 name: 2-oxoglutarate + N(6)-acetyl-L-lysine = 6-acetamido-2-oxohexanoate + L-glutamate namespace: reaction xref: KEGG:R04029 "KEGG reaction" xref: METACYC:ACETCAPR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:42507 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC02727 {cardinality="1"} ! N(6)-acetyl-L-lysine relationship: has_input_compound UPa:UPC02727 ! N(6)-acetyl-L-lysine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC05548 ! 6-acetamido-2-oxohexanoate relationship: has_output_compound UPa:UPC05548 {cardinality="1"} ! 6-acetamido-2-oxohexanoate relationship: part_of UPa:UER00842 ! glutarate from L-lysine: step 2/6 relationship: part_of UPa:UER00842 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 2/6 [Term] id: UPa:UCR04030 name: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate namespace: reaction xref: KEGG:R04030 "KEGG reaction" xref: METACYC:O-SUCCINYLBENZOATE-COA-LIG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17012 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC02730 {cardinality="1"} ! 2-succinylbenzoate relationship: has_input_compound UPa:UPC02730 ! 2-succinylbenzoate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC03160 {cardinality="1"} ! 2-succinylbenzoyl-CoA relationship: has_output_compound UPa:UPC03160 ! 2-succinylbenzoyl-CoA relationship: part_of UPa:UER00166 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7 relationship: part_of UPa:UER00166 ! 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7 [Term] id: UPa:UCR04031 name: 2-succinylbenzoate + H(2)O = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid namespace: reaction xref: KEGG:R04031 "KEGG reaction" xref: METACYC:O-SUCCINYLBENZOATE-COA-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10199 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC02730 {cardinality="1"} ! 2-succinylbenzoate relationship: has_input_compound UPa:UPC02730 ! 2-succinylbenzoate relationship: has_output_compound UPa:UPC05817 ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid relationship: has_output_compound UPa:UPC05817 {cardinality="1"} ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid relationship: part_of UPa:UER00165 ! 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7 relationship: part_of UPa:UER00165 {cardinality="1", direction="RL", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7 [Term] id: UPa:UCR04035 name: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphoribosyl)-5'-AMP + diphosphate namespace: reaction xref: KEGG:R04035 "KEGG reaction" xref: METACYC:HISTPRATPHYD-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22831 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC02739 {cardinality="1"} ! 1-(5-phospho-D-ribosyl)-ATP relationship: has_input_compound UPa:UPC02739 ! 1-(5-phospho-D-ribosyl)-ATP relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC02741 ! 1-(5-phosphoribosyl)-5'-AMP relationship: has_output_compound UPa:UPC02741 {cardinality="1"} ! 1-(5-phosphoribosyl)-5'-AMP relationship: part_of UPa:UER00007 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9 relationship: part_of UPa:UER00007 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9 [Term] id: UPa:UCR04037 name: 1-(5-phosphoribosyl)-5'-AMP + H(2)O = 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide namespace: reaction xref: KEGG:R04037 "KEGG reaction" xref: METACYC:HISTCYCLOHYD-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20052 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC02741 {cardinality="1"} ! 1-(5-phosphoribosyl)-5'-AMP relationship: has_input_compound UPa:UPC02741 ! 1-(5-phosphoribosyl)-5'-AMP relationship: has_output_compound UPa:UPC04896 ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04896 {cardinality="1"} ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide relationship: part_of UPa:UER00008 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9 relationship: part_of UPa:UER00008 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9 [Term] id: UPa:UCR04061 name: O(2) + benzene-1,2,4-triol = 3-hydroxy-cis,cis-muconate namespace: reaction xref: KEGG:R04061 "KEGG reaction" xref: METACYC:RXN-10137 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19444 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC02814 ! benzene-1,2,4-triol relationship: has_input_compound UPa:UPC02814 {cardinality="1"} ! benzene-1,2,4-triol relationship: has_output_compound UPa:UPC03676 ! 3-hydroxy-cis,cis-muconate relationship: has_output_compound UPa:UPC03676 {cardinality="1"} ! 3-hydroxy-cis,cis-muconate relationship: part_of UPa:UER00268 ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 2/4 relationship: part_of UPa:UER00268 {cardinality="1", direction="LR", order="1"} ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 2/4 [Term] id: UPa:UCR04088 name: (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + H(+) + NADH namespace: reaction xref: KEGG:R04088 "KEGG reaction" xref: METACYC:TOLUENE-DIOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25196 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC04592 {cardinality="1"} ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol relationship: has_input_compound UPa:UPC04592 ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC02923 {cardinality="1"} ! 3-methylcatechol relationship: has_output_compound UPa:UPC02923 ! 3-methylcatechol relationship: part_of UPa:UER00394 ! 3-methylcatechol from toluene: step 2/2 relationship: part_of UPa:UER00394 {cardinality="1", direction="LR", order="1"} ! 3-methylcatechol from toluene: step 2/2 [Term] id: UPa:UCR04095 name: 3-isovaleryl-CoA + FAD = 3-methylcrotonyl-CoA + FADH2 namespace: reaction xref: KEGG:R04095 "KEGG reaction" xref: METACYC:RXN-14264 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:31066 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00016 {cardinality="1"} ! FAD relationship: has_input_compound UPa:UPC00016 ! FAD relationship: has_input_compound UPa:UPC02939 {cardinality="1"} ! 3-isovaleryl-CoA relationship: has_input_compound UPa:UPC02939 ! 3-isovaleryl-CoA relationship: has_output_compound UPa:UPC01352 ! FADH2 relationship: has_output_compound UPa:UPC01352 {cardinality="1"} ! FADH2 relationship: has_output_compound UPa:UPC03069 ! 3-methylcrotonyl-CoA relationship: has_output_compound UPa:UPC03069 {cardinality="1"} ! 3-methylcrotonyl-CoA relationship: part_of UPa:UER00860 {cardinality="1", direction="LR", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3 relationship: part_of UPa:UER00860 ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3 [Term] id: UPa:UCR04101 name: 4-chlorobenzoyl-CoA + H(2)O = 4-hydroxybenzoyl-CoA + H(+) + chloride namespace: reaction xref: KEGG:R04101 "KEGG reaction" xref: METACYC:3.8.1.7-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14856 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06387 ! 4-chlorobenzoyl-CoA relationship: has_input_compound UPa:UPC06387 {cardinality="1"} ! 4-chlorobenzoyl-CoA relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00698 ! chloride relationship: has_output_compound UPa:UPC00698 {cardinality="1"} ! chloride relationship: has_output_compound UPa:UPC02949 ! 4-hydroxybenzoyl-CoA relationship: has_output_compound UPa:UPC02949 {cardinality="1"} ! 4-hydroxybenzoyl-CoA relationship: part_of UPa:UER01021 {cardinality="1", direction="LR", order="1"} ! 4-hydroxybenzoate from 4-chlorobenzoate: step 2/3 relationship: part_of UPa:UER01021 ! 4-hydroxybenzoate from 4-chlorobenzoate: step 2/3 [Term] id: UPa:UCR04109 name: H(+) + L-glutamyl-tRNA(Glu) + NADPH = (S)-4-amino-5-oxopentanoic acid + NADP(+) + tRNA(Glu) namespace: reaction xref: KEGG:R04109 "KEGG reaction" xref: METACYC:GLUTRNAREDUCT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12347 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC02987 ! L-glutamyl-tRNA(Glu) relationship: has_input_compound UPa:UPC02987 {cardinality="1"} ! L-glutamyl-tRNA(Glu) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC01641 {cardinality="1"} ! tRNA(Glu) relationship: has_output_compound UPa:UPC01641 ! tRNA(Glu) relationship: has_output_compound UPa:UPC03741 ! (S)-4-amino-5-oxopentanoic acid relationship: has_output_compound UPa:UPC03741 {cardinality="1"} ! (S)-4-amino-5-oxopentanoic acid relationship: part_of UPa:UER00316 {cardinality="1", direction="LR", order="1"} ! 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2 relationship: part_of UPa:UER00316 ! 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2 [Term] id: UPa:UCR04138 name: 3-methylcrotonyl-CoA + ATP + bicarbonate = 3-methylglutaconyl-CoA + ADP + phosphate namespace: reaction xref: KEGG:R04138 "KEGG reaction" xref: METACYC:METHYLCROTONYL-COA-CARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13592 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_input_compound UPa:UPC03069 ! 3-methylcrotonyl-CoA relationship: has_input_compound UPa:UPC03069 {cardinality="1"} ! 3-methylcrotonyl-CoA relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC03231 ! 3-methylglutaconyl-CoA relationship: has_output_compound UPa:UPC03231 {cardinality="1"} ! 3-methylglutaconyl-CoA relationship: part_of UPa:UER00861 ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3 relationship: part_of UPa:UER00861 {cardinality="1", direction="LR", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3 [Term] id: UPa:UCR04142 name: 5-acetamidopentanoate + CO(2) + H(+) + NADH = 6-acetamido-2-oxohexanoate + H(2)O + NAD(+) namespace: reaction xref: KEGG:R04142 "KEGG reaction" xref: METACYC:KETAMID-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42511 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC03087 {cardinality="1"} ! 5-acetamidopentanoate relationship: has_input_compound UPa:UPC03087 ! 5-acetamidopentanoate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC05548 ! 6-acetamido-2-oxohexanoate relationship: has_output_compound UPa:UPC05548 {cardinality="1"} ! 6-acetamido-2-oxohexanoate relationship: part_of UPa:UER00843 {cardinality="1", direction="RL", order="1"} ! glutarate from L-lysine: step 3/6 relationship: part_of UPa:UER00843 ! glutarate from L-lysine: step 3/6 [Term] id: UPa:UCR04143 name: 5-methylthio-alpha-D-ribose + ATP = ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate namespace: reaction xref: KEGG:R04143 "KEGG reaction" xref: METACYC:5-METHYLTHIORIBOSE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22315 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC03089 {cardinality="1"} ! 5-methylthio-alpha-D-ribose relationship: has_input_compound UPa:UPC03089 ! 5-methylthio-alpha-D-ribose relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04188 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC04188 {cardinality="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:UER00872 {cardinality="1", direction="LR", order="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 2/2 relationship: part_of UPa:UER00872 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 2/2 [Term] id: UPa:UCR04144 name: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate namespace: reaction xref: KEGG:R04144 "KEGG reaction" xref: METACYC:GLYRIBONUCSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17456 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC03090 {cardinality="1"} ! 5-phospho-beta-D-ribosylamine relationship: has_input_compound UPa:UPC03090 ! 5-phospho-beta-D-ribosylamine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC03838 ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC03838 {cardinality="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:UER00125 {cardinality="1", direction="LR", order="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2 relationship: part_of UPa:UER00125 ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2 [Term] id: UPa:UCR04148 name: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = H(+) + alpha-ribazole 5'-phosphate + nicotinate namespace: reaction xref: KEGG:R04148 "KEGG reaction" xref: METACYC:DMBPPRIBOSYLTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11199 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01185 ! nicotinate D-ribonucleotide relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide relationship: has_input_compound UPa:UPC03114 {cardinality="1"} ! 5,6-dimethylbenzimidazole relationship: has_input_compound UPa:UPC03114 ! 5,6-dimethylbenzimidazole relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00253 ! nicotinate relationship: has_output_compound UPa:UPC00253 {cardinality="1"} ! nicotinate relationship: has_output_compound UPa:UPC04778 ! alpha-ribazole 5'-phosphate relationship: has_output_compound UPa:UPC04778 {cardinality="1"} ! alpha-ribazole 5'-phosphate relationship: part_of UPa:UER00516 ! alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2 relationship: part_of UPa:UER00516 {cardinality="1", direction="LR", order="1"} ! alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2 [Term] id: UPa:UCR04173 name: 2-oxoglutarate + O-phospho-L-serine = 3-phosphohydroxypyruvate + L-glutamate namespace: reaction xref: KEGG:R04173 "KEGG reaction" xref: METACYC:PSERTRANSAM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14332 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC01005 {cardinality="1"} ! O-phospho-L-serine relationship: has_input_compound UPa:UPC01005 ! O-phospho-L-serine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC03232 ! 3-phosphohydroxypyruvate relationship: has_output_compound UPa:UPC03232 {cardinality="1"} ! 3-phosphohydroxypyruvate relationship: part_of UPa:UER00197 {cardinality="1", direction="RL", order="1"} ! L-serine from 3-phospho-D-glycerate: step 2/3 relationship: part_of UPa:UER00197 ! L-serine from 3-phospho-D-glycerate: step 2/3 [Term] id: UPa:UCR04189 name: 2 H(2)O + N(2)-succinyl-L-arginine = CO(2) + N(2)-succinyl-L-ornithine + 2 NH(3) namespace: reaction xref: KEGG:R04189 "KEGG reaction" xref: METACYC:SUCCARGDIHYDRO-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19536 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC03296 {cardinality="1"} ! N(2)-succinyl-L-arginine relationship: has_input_compound UPa:UPC03296 ! N(2)-succinyl-L-arginine relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC03415 ! N(2)-succinyl-L-ornithine relationship: has_output_compound UPa:UPC03415 {cardinality="1"} ! N(2)-succinyl-L-ornithine relationship: part_of UPa:UER00280 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 2/5 relationship: part_of UPa:UER00280 ! L-glutamate and succinate from L-arginine: step 2/5 [Term] id: UPa:UCR04198 name: (S)-tetrahydrodipicolinate + H(2)O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH namespace: reaction xref: KEGG:R04198 "KEGG reaction" xref: RHEA:35326 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC20258 ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC20258 {cardinality="1"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: part_of UPa:UER01028 ! None relationship: part_of UPa:UER01028 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR04199 name: (S)-tetrahydrodipicolinate + H(2)O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH namespace: reaction xref: KEGG:R04199 "KEGG reaction" xref: RHEA:35334 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC20258 ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC20258 {cardinality="1"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: part_of UPa:UER01029 ! None relationship: part_of UPa:UER01029 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR04208 name: 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + phosphate namespace: reaction xref: KEGG:R04208 "KEGG reaction" xref: METACYC:AIRS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23035 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC04640 {cardinality="1"} ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine relationship: has_input_compound UPa:UPC04640 ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:UER00129 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2 relationship: part_of UPa:UER00129 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2 [Term] id: UPa:UCR04209 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2) namespace: reaction xref: KEGG:R04209 "KEGG reaction" xref: METACYC:AIRCARBOXY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10795 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04751 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_input_compound UPa:UPC04751 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:UER00130 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1 relationship: part_of UPa:UER00130 {cardinality="1", direction="RL", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1 [Term] id: UPa:UCR04210 name: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid + H(+) + NADH namespace: reaction xref: KEGG:R04210 "KEGG reaction" xref: METACYC:ERYTHRON4PDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18832 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC03393 {cardinality="1"} ! 4-phospho-D-erythronate relationship: has_input_compound UPa:UPC03393 ! 4-phospho-D-erythronate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC06054 {cardinality="1"} ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid relationship: has_output_compound UPa:UPC06054 ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid relationship: part_of UPa:UER00310 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 2/5 relationship: part_of UPa:UER00310 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 2/5 [Term] id: UPa:UCR04217 name: 2-oxoglutarate + N(2)-succinyl-L-ornithine = L-glutamate + N-succinyl-L-glutamate 5-semialdehyde namespace: reaction xref: KEGG:R04217 "KEGG reaction" xref: METACYC:SUCCORNTRANSAM-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16956 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC03415 {cardinality="1"} ! N(2)-succinyl-L-ornithine relationship: has_input_compound UPa:UPC03415 ! N(2)-succinyl-L-ornithine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC05932 {cardinality="1"} ! N-succinyl-L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC05932 ! N-succinyl-L-glutamate 5-semialdehyde relationship: part_of UPa:UER00281 ! L-glutamate and succinate from L-arginine: step 3/5 relationship: part_of UPa:UER00281 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 3/5 [Term] id: UPa:UCR04218 name: prephytoene diphosphate = 15-cis-phytoene + diphosphate namespace: reaction xref: KEGG:R04218 "KEGG reaction" xref: RHEA:34482 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03427 {cardinality="1"} ! prephytoene diphosphate relationship: has_input_compound UPa:UPC03427 ! prephytoene diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC05421 {cardinality="1"} ! 15-cis-phytoene relationship: has_output_compound UPa:UPC05421 ! 15-cis-phytoene relationship: part_of UPa:UER01030 {cardinality="1", direction="LR", order="2"} ! 15-cis-phytoene from geranylgeranyl diphosphate: step 1/1 relationship: part_of UPa:UER01030 ! 15-cis-phytoene from geranylgeranyl diphosphate: step 1/1 [Term] id: UPa:UCR04231 name: (R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + N-[(R)-4-phosphonopantothenoyl]-L-cysteine + diphosphate namespace: reaction xref: KEGG:R04231 "KEGG reaction" xref: METACYC:P-PANTOCYSLIG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19400 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_input_compound UPa:UPC03492 {cardinality="1"} ! (R)-4'-phosphopantothenate relationship: has_input_compound UPa:UPC03492 ! (R)-4'-phosphopantothenate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC04352 {cardinality="1"} ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine relationship: has_output_compound UPa:UPC04352 ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine relationship: part_of UPa:UER00353 ! CoA from (R)-pantothenate: step 2/5 relationship: part_of UPa:UER00353 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 2/5 [Term] id: UPa:UCR04265 name: CDP-3,6-dideoxy-D-glucose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-D-glucose + H(+) + NADPH namespace: reaction xref: KEGG:R04265 "KEGG reaction" xref: METACYC:RXN-9159 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:34570 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC03598 {cardinality="1"} ! CDP-3,6-dideoxy-D-glucose relationship: has_input_compound UPa:UPC03598 ! CDP-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC04297 {cardinality="1"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC04297 ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: part_of UPa:UER00514 {cardinality="1", direction="RL", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 4/5 relationship: part_of UPa:UER00514 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 4/5 [Term] id: UPa:UCR04266 name: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose namespace: reaction xref: KEGG:R04266 "KEGG reaction" xref: METACYC:RXN-9160 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21659 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03598 {cardinality="1"} ! CDP-3,6-dideoxy-D-glucose relationship: has_input_compound UPa:UPC03598 ! CDP-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC03599 ! CDP-3,6-dideoxy-D-mannose relationship: has_output_compound UPa:UPC03599 {cardinality="1"} ! CDP-3,6-dideoxy-D-mannose relationship: part_of UPa:UER00515 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 5/5 relationship: part_of UPa:UER00515 {cardinality="1", direction="LR", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 5/5 [Term] id: UPa:UCR04285 name: 6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-tetrahydropterin + H(+) + NADPH namespace: reaction xref: KEGG:R04285 "KEGG reaction" xref: METACYC:1.1.1.220-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11775 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC04244 ! 6-lactoyl-5,6,7,8-tetrahydropterin relationship: has_input_compound UPa:UPC04244 {cardinality="1"} ! 6-lactoyl-5,6,7,8-tetrahydropterin relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03684 ! 6-pyruvoyl-tetrahydropterin relationship: has_output_compound UPa:UPC03684 {cardinality="1"} ! 6-pyruvoyl-tetrahydropterin relationship: part_of UPa:UER00820 ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 2/3 relationship: part_of UPa:UER00820 {cardinality="1", direction="RL", order="1"} ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 2/3 [Term] id: UPa:UCR04286 name: 7,8-dihydroneopterin triphosphate = 6-pyruvoyl-tetrahydropterin + triphosphate namespace: reaction xref: KEGG:R04286 "KEGG reaction" xref: METACYC:4.2.3.12-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22051 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04895 ! 7,8-dihydroneopterin triphosphate relationship: has_input_compound UPa:UPC04895 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC00536 {cardinality="1"} ! triphosphate relationship: has_output_compound UPa:UPC00536 ! triphosphate relationship: has_output_compound UPa:UPC03684 ! 6-pyruvoyl-tetrahydropterin relationship: has_output_compound UPa:UPC03684 {cardinality="1"} ! 6-pyruvoyl-tetrahydropterin relationship: part_of UPa:UER00819 ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3 relationship: part_of UPa:UER00819 {cardinality="1", direction="LR", order="1"} ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3 [Term] id: UPa:UCR04292 name: 2 H(2)O + phosphate + quinolinate = glycerone phosphate + iminoaspartate namespace: reaction xref: KEGG:R04292 "KEGG reaction" xref: METACYC:QUINOLINATE-SYNTHA-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25891 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC03722 {cardinality="1"} ! quinolinate relationship: has_input_compound UPa:UPC03722 ! quinolinate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC05840 ! iminoaspartate relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate relationship: part_of UPa:UER00327 {cardinality="1", direction="RL", order="1"} ! quinolinate from iminoaspartate: step 1/1 relationship: part_of UPa:UER00327 ! quinolinate from iminoaspartate: step 1/1 [Term] id: UPa:UCR04293 name: H(2)O + quinolinate = 2-amino-3-carboxymuconate semialdehyde namespace: reaction xref: KEGG:R04293 "KEGG reaction" xref: METACYC:RXN-5721 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25150 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC03722 {cardinality="1"} ! quinolinate relationship: has_input_compound UPa:UPC03722 ! quinolinate relationship: has_output_compound UPa:UPC04409 ! 2-amino-3-carboxymuconate semialdehyde relationship: has_output_compound UPa:UPC04409 {cardinality="1"} ! 2-amino-3-carboxymuconate semialdehyde relationship: part_of UPa:UER00330 {cardinality="1", direction="RL", order="2"} ! quinolinate from L-kynurenine: step 3/3 relationship: part_of UPa:UER00330 ! quinolinate from L-kynurenine: step 3/3 [Term] id: UPa:UCR04296 name: (S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose = UDP + dhurrin namespace: reaction xref: KEGG:R04296 "KEGG reaction" xref: METACYC:RXN-743 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12856 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00029 {cardinality="1"} ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC00029 ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC03742 {cardinality="1"} ! (S)-4-hydroxymandelonitrile relationship: has_input_compound UPa:UPC03742 ! (S)-4-hydroxymandelonitrile relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC05143 {cardinality="1"} ! dhurrin relationship: has_output_compound UPa:UPC05143 ! dhurrin relationship: part_of UPa:UER00746 {cardinality="1", direction="LR", order="1"} ! dhurrin from L-tyrosine: step 3/3 relationship: part_of UPa:UER00746 ! dhurrin from L-tyrosine: step 3/3 [Term] id: UPa:UCR04325 name: 10-formyl-5,6,7,8-tetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = 5,6,7,8-tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide namespace: reaction xref: KEGG:R04325 "KEGG reaction" xref: METACYC:GART-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15056 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00234 ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00234 {cardinality="1"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC03838 ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_input_compound UPa:UPC03838 {cardinality="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC04376 {cardinality="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC04376 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:UER00126 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1 relationship: part_of UPa:UER00126 {cardinality="1", direction="LR", order="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1 [Term] id: UPa:UCR04336 name: (S)-2-amino-6-oxopimelate = (S)-tetrahydrodipicolinate + H(2)O namespace: reaction xref: KEGG:R04336 "KEGG reaction" xref: METACYC:RXN-4821 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24800 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03871 ! (S)-2-amino-6-oxopimelate relationship: has_input_compound UPa:UPC03871 {cardinality="1"} ! (S)-2-amino-6-oxopimelate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: part_of UPa:UER00026 {cardinality="1", direction="RL", order="1"} ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1 relationship: part_of UPa:UER00026 ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1 [Term] id: UPa:UCR04347 name: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M namespace: reaction xref: KEGG:R04347 "KEGG reaction" xref: METACYC:2.1.1.86-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17588 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03576 {cardinality="1"} ! coenzyme M relationship: has_input_compound UPa:UPC03576 ! coenzyme M relationship: has_input_compound UPa:UPC04488 {cardinality="1"} ! 5-methyl-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04488 ! 5-methyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01217 {cardinality="1"} ! 5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01217 ! 5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC03920 ! methyl-coenzyme M relationship: has_output_compound UPa:UPC03920 {cardinality="1"} ! methyl-coenzyme M relationship: part_of UPa:UER00698 ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2 relationship: part_of UPa:UER00698 {cardinality="1", direction="LR", order="1"} ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2 [Term] id: UPa:UCR04364 name: (S)-tetrahydrodipicolinate + H(2)O + acetyl-CoA = (S)-2-acetamido-6-oxopimelate + CoA namespace: reaction xref: KEGG:R04364 "KEGG reaction" xref: METACYC:2.3.1.89-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13088 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC05539 ! (S)-2-acetamido-6-oxopimelate relationship: has_output_compound UPa:UPC05539 {cardinality="1"} ! (S)-2-acetamido-6-oxopimelate relationship: part_of UPa:UER00022 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3 relationship: part_of UPa:UER00022 {cardinality="1", direction="LR", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3 [Term] id: UPa:UCR04365 name: (S)-tetrahydrodipicolinate + H(2)O + succinyl-CoA = CoA + L-2-succinylamino-6-oxopimelate namespace: reaction xref: KEGG:R04365 "KEGG reaction" xref: METACYC:TETHYDPICSUCC-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17328 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC04462 {cardinality="1"} ! L-2-succinylamino-6-oxopimelate relationship: has_output_compound UPa:UPC04462 ! L-2-succinylamino-6-oxopimelate relationship: part_of UPa:UER00019 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3 relationship: part_of UPa:UER00019 {cardinality="1", direction="LR", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3 [Term] id: UPa:UCR04371 name: homoisocitrate = H(2)O + homo-cis-aconitate namespace: reaction xref: KEGG:R04371 "KEGG reaction" xref: METACYC:HOMOACONITATE-HYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15488 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC05662 ! homoisocitrate relationship: has_input_compound UPa:UPC05662 {cardinality="1"} ! homoisocitrate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC04002 ! homo-cis-aconitate relationship: has_output_compound UPa:UPC04002 {cardinality="1"} ! homo-cis-aconitate relationship: part_of UPa:UER01027 {cardinality="1", direction="RL", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 3/5 relationship: part_of UPa:UER01027 ! L-alpha-aminoadipate from 2-oxoglutarate: step 3/5 [Term] id: UPa:UCR04376 name: 3-(2,3-dihydroxyphenyl)propanoate + O(2) = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate namespace: reaction xref: KEGG:R04376 "KEGG reaction" xref: METACYC:1.13.11.16-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23843 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC04044 ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_input_compound UPa:UPC04044 {cardinality="1"} ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC04479 ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate relationship: has_output_compound UPa:UPC04479 {cardinality="1"} ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate relationship: part_of UPa:UER00794 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 1/4 relationship: part_of UPa:UER00794 ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 1/4 [Term] id: UPa:UCR04379 name: 5-carboxymethyl-2-hydroxymuconic acid = 5-oxopent-3-ene-1,2,5-tricarboxylic acid namespace: reaction xref: KEGG:R04379 "KEGG reaction" xref: METACYC:5.3.3.10-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18816 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04186 {cardinality="1"} ! 5-carboxymethyl-2-hydroxymuconic acid relationship: has_input_compound UPa:UPC04186 ! 5-carboxymethyl-2-hydroxymuconic acid relationship: has_output_compound UPa:UPC04052 ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid relationship: has_output_compound UPa:UPC04052 {cardinality="1"} ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid relationship: part_of UPa:UER00419 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 4/7 relationship: part_of UPa:UER00419 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 4/7 [Term] id: UPa:UCR04380 name: 5-oxopent-3-ene-1,2,5-tricarboxylic acid = 2-hydroxy-hept-2,4-diene-1,7-dioic acid + CO(2) namespace: reaction xref: KEGG:R04380 "KEGG reaction" xref: METACYC:CARBOXY-OXOHEPT-ENEDIOATE-DECARBOXY-RXN "MetaCyc REACTION" {source="MetaCyc"} is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04052 {cardinality="1"} ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid relationship: has_input_compound UPa:UPC04052 ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC05600 {cardinality="1"} ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid relationship: has_output_compound UPa:UPC05600 ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid relationship: part_of UPa:UER00420 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 5/7 relationship: part_of UPa:UER00420 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 5/7 [Term] id: UPa:UCR04382 name: 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid = 2 5-dehydro-4-deoxy-D-glucuronic acid namespace: reaction xref: KEGG:R04382 "KEGG reaction" xref: METACYC:OLIGOGALACTURONIDE-LYASE-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:20272 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06118 ! 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid relationship: has_input_compound UPa:UPC06118 {cardinality="1"} ! 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid relationship: has_output_compound UPa:UPC04053 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucuronic acid relationship: has_output_compound UPa:UPC04053 ! 5-dehydro-4-deoxy-D-glucuronic acid relationship: part_of UPa:UER00825 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 3/5 relationship: part_of UPa:UER00825 ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 3/5 [Term] id: UPa:UCR04383 name: 5-dehydro-4-deoxy-D-glucuronic acid = 3-deoxy-D-glycero-hexo-2,5-diulosonate namespace: reaction xref: KEGG:R04383 "KEGG reaction" xref: METACYC:5.3.1.17-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23899 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04053 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucuronic acid relationship: has_input_compound UPa:UPC04053 ! 5-dehydro-4-deoxy-D-glucuronic acid relationship: has_output_compound UPa:UPC04349 ! 3-deoxy-D-glycero-hexo-2,5-diulosonate relationship: has_output_compound UPa:UPC04349 {cardinality="1"} ! 3-deoxy-D-glycero-hexo-2,5-diulosonate relationship: part_of UPa:UER00826 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5 relationship: part_of UPa:UER00826 ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5 [Term] id: UPa:UCR04390 name: H(+) + NADPH + alpha-aminoadipoyl-S-acyl enzyme = L-2-aminoadipate 6-semialdahyde + NADP(+) + holo-Lys2 namespace: reaction xref: KEGG:R04390 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC05535 {cardinality="1"} ! alpha-aminoadipoyl-S-acyl enzyme relationship: has_input_compound UPa:UPC05535 ! alpha-aminoadipoyl-S-acyl enzyme relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC11482 {cardinality="1"} ! holo-Lys2 relationship: has_output_compound UPa:UPC11482 ! holo-Lys2 relationship: part_of UPa:UER00032 {cardinality="1", direction="LR", order="3"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3 relationship: part_of UPa:UER00032 ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3 [Term] id: UPa:UCR04393 name: lactose + protein N(pi)-phospho-L-histidine = lactose 6-phosphate + protein-L-histidine namespace: reaction xref: KEGG:R04393 "KEGG reaction" xref: RHEA:42403 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00243 {cardinality="1"} ! lactose relationship: has_input_compound UPa:UPC00243 ! lactose relationship: has_input_compound UPa:UPC04261 {cardinality="1"} ! protein N(pi)-phospho-L-histidine relationship: has_input_compound UPa:UPC04261 ! protein N(pi)-phospho-L-histidine relationship: has_output_compound UPa:UPC00615 {cardinality="1"} ! protein-L-histidine relationship: has_output_compound UPa:UPC00615 ! protein-L-histidine relationship: has_output_compound UPa:UPC05396 {cardinality="1"} ! lactose 6-phosphate relationship: has_output_compound UPa:UPC05396 ! lactose 6-phosphate relationship: part_of UPa:UER00604 {cardinality="1", direction="LR", order="1"} ! lactose 6-phosphate from lactose (PTS route): step 1/1 relationship: part_of UPa:UER00604 ! lactose 6-phosphate from lactose (PTS route): step 1/1 [Term] id: UPa:UCR04405 name: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate namespace: reaction xref: KEGG:R04405 "KEGG reaction" xref: METACYC:HOMOCYSMET-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21199 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_input_compound UPa:UPC04489 ! 5-methyltetrahydropteroyltri-L-glutamate relationship: has_input_compound UPa:UPC04489 {cardinality="1"} ! 5-methyltetrahydropteroyltri-L-glutamate relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC04144 {cardinality="1"} ! tetrahydropteroyltri-L-glutamate relationship: has_output_compound UPa:UPC04144 ! tetrahydropteroyltri-L-glutamate relationship: part_of UPa:UER00082 ! L-methionine from L-homocysteine (MetE route): step 1/1 relationship: part_of UPa:UER00082 {cardinality="1", direction="LR", order="1"} ! L-methionine from L-homocysteine (MetE route): step 1/1 [Term] id: UPa:UCR04418 name: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H(2)O + NAD(+) = 5-carboxymethyl-2-hydroxymuconic acid + H(+) + NADH namespace: reaction xref: KEGG:R04418 "KEGG reaction" xref: METACYC:CHMS-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15684 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC04642 ! 5-carboxymethyl-2-hydroxymuconate semialdehyde relationship: has_input_compound UPa:UPC04642 {cardinality="1"} ! 5-carboxymethyl-2-hydroxymuconate semialdehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC04186 ! 5-carboxymethyl-2-hydroxymuconic acid relationship: has_output_compound UPa:UPC04186 {cardinality="1"} ! 5-carboxymethyl-2-hydroxymuconic acid relationship: part_of UPa:UER00418 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 3/7 relationship: part_of UPa:UER00418 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 3/7 [Term] id: UPa:UCR04420 name: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate namespace: reaction xref: KEGG:R04420 "KEGG reaction" xref: METACYC:5.3.1.23-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19992 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04188 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_input_compound UPa:UPC04188 {cardinality="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC04582 ! S-methyl-5-thio-D-ribulose 1-phosphate relationship: has_output_compound UPa:UPC04582 {cardinality="1"} ! S-methyl-5-thio-D-ribulose 1-phosphate relationship: part_of UPa:UER00874 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6 relationship: part_of UPa:UER00874 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6 [Term] id: UPa:UCR04426 name: (2R,3S)-3-isopropylmalate + NAD(+) = 3-carboxy-4-methyl-2-oxopentanoate + H(+) + NADH namespace: reaction xref: KEGG:R04426 "KEGG reaction" xref: METACYC:3-ISOPROPYLMALDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10895 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC04411 {cardinality="1"} ! (2R,3S)-3-isopropylmalate relationship: has_input_compound UPa:UPC04411 ! (2R,3S)-3-isopropylmalate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04236 ! 3-carboxy-4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC04236 {cardinality="1"} ! 3-carboxy-4-methyl-2-oxopentanoate relationship: part_of UPa:UER00072 {cardinality="1", direction="LR", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate: step 3/4 relationship: part_of UPa:UER00072 ! L-leucine from 3-methyl-2-oxobutanoate: step 3/4 [Term] id: UPa:UCR04427 name: S-adenosyl-L-methionine + zymosterol = S-adenosyl-L-homocysteine + fecosterol namespace: reaction xref: KEGG:R04427 "KEGG reaction" xref: METACYC:RXN3O-178 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21131 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC05437 ! zymosterol relationship: has_input_compound UPa:UPC05437 {cardinality="1"} ! zymosterol relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC04525 ! fecosterol relationship: has_output_compound UPa:UPC04525 {cardinality="1"} ! fecosterol relationship: part_of UPa:UER00760 {cardinality="1", direction="LR", order="1"} ! ergosterol from zymosterol: step 1/5 relationship: part_of UPa:UER00760 ! ergosterol from zymosterol: step 1/5 [Term] id: UPa:UCR04440 name: (R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = 2-oxo-3-hydroxyisovalerate + H(+) + NADPH namespace: reaction xref: KEGG:R04440 "KEGG reaction" xref: RHEA:31142 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC04272 {cardinality="1"} ! (R)-2,3-dihydroxy-3-methylbutanoate relationship: has_input_compound UPa:UPC04272 ! (R)-2,3-dihydroxy-3-methylbutanoate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC04181 {cardinality="1"} ! 2-oxo-3-hydroxyisovalerate relationship: has_output_compound UPa:UPC04181 ! 2-oxo-3-hydroxyisovalerate relationship: part_of UPa:UER00060 {cardinality="1", direction="RL", order="2"} ! L-valine from pyruvate: step 2/4 relationship: part_of UPa:UER00060 ! L-valine from pyruvate: step 2/4 [Term] id: UPa:UCR04441 name: (R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H(2)O namespace: reaction xref: KEGG:R04441 "KEGG reaction" xref: METACYC:DIHYDROXYISOVALDEHYDRAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24812 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04272 ! (R)-2,3-dihydroxy-3-methylbutanoate relationship: has_input_compound UPa:UPC04272 {cardinality="1"} ! (R)-2,3-dihydroxy-3-methylbutanoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate relationship: has_output_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate relationship: part_of UPa:UER00061 ! L-valine from pyruvate: step 3/4 relationship: part_of UPa:UER00061 {cardinality="1", direction="LR", order="1"} ! L-valine from pyruvate: step 3/4 [Term] id: UPa:UCR04448 name: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP namespace: reaction xref: KEGG:R04448 "KEGG reaction" xref: METACYC:THIAZOLSYN3-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24215 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC04294 ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: has_input_compound UPa:UPC04294 {cardinality="1"} ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC04327 {cardinality="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_output_compound UPa:UPC04327 ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: part_of UPa:UER00139 ! 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1 relationship: part_of UPa:UER00139 {cardinality="1", direction="LR", order="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1 [Term] id: UPa:UCR04455 name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylene-5,6,7,8-tetrahydromethanopterin + H(+) namespace: reaction xref: KEGG:R04455 "KEGG reaction" xref: METACYC:H2-METHYLENE-THMPT-DEHYDRO-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20020 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00282 ! H(2) relationship: has_input_compound UPa:UPC00282 {cardinality="1"} ! H(2) relationship: has_input_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00696 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (hydrogen route): step 1/1 relationship: part_of UPa:UER00696 {cardinality="1", direction="LR", order="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (hydrogen route): step 1/1 [Term] id: UPa:UCR04456 name: 5,10-methylene-5,6,7,8-tetrahydromethanopterin + coenzyme F420 = 1,5-dihydro-coenzyme F(420) + 5,10-methenyl-5,6,7,8-tetrahydromethanopterin namespace: reaction xref: KEGG:R04456 "KEGG reaction" xref: METACYC:1.5.99.9-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16724 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00876 {cardinality="1"} ! coenzyme F420 relationship: has_input_compound UPa:UPC00876 ! coenzyme F420 relationship: has_input_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01080 ! 1,5-dihydro-coenzyme F(420) relationship: has_output_compound UPa:UPC01080 {cardinality="1"} ! 1,5-dihydro-coenzyme F(420) relationship: has_output_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00695 {cardinality="1", direction="RL", order="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route): step 1/1 relationship: part_of UPa:UER00695 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route): step 1/1 [Term] id: UPa:UCR04457 name: 2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + 2 H(2)O + phosphate namespace: reaction xref: KEGG:R04457 "KEGG reaction" xref: METACYC:LUMAZINESYN-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:26155 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04732 {cardinality="1"} ! 5-amino-6-(D-ribitylamino)uracil relationship: has_input_compound UPa:UPC04732 ! 5-amino-6-(D-ribitylamino)uracil relationship: has_input_compound UPa:UPC15556 {cardinality="1"} ! 2-hydroxy-3-oxobutyl phosphate relationship: has_input_compound UPa:UPC15556 ! 2-hydroxy-3-oxobutyl phosphate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC04332 ! 6,7-dimethyl-8-(1-D-ribityl)lumazine relationship: has_output_compound UPa:UPC04332 {cardinality="1"} ! 6,7-dimethyl-8-(1-D-ribityl)lumazine relationship: part_of UPa:UER00404 ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2 relationship: part_of UPa:UER00404 {cardinality="1", direction="LR", order="1"} ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2 [Term] id: UPa:UCR04463 name: ATP + H(2)O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine + ADP + L-glutamate + phosphate namespace: reaction xref: KEGG:R04463 "KEGG reaction" xref: METACYC:FGAMSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17132 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC04376 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_input_compound UPa:UPC04376 {cardinality="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC04640 {cardinality="1"} ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine relationship: has_output_compound UPa:UPC04640 ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine relationship: part_of UPa:UER00128 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2 relationship: part_of UPa:UER00128 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2 [Term] id: UPa:UCR04464 name: 1,5-dihydro-coenzyme F(420) + 5,10-methylene-5,6,7,8-tetrahydromethanopterin = 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme F420 namespace: reaction xref: KEGG:R04464 "KEGG reaction" xref: METACYC:METHELENE-THMPT-OXI-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21147 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01080 {cardinality="1"} ! 1,5-dihydro-coenzyme F(420) relationship: has_input_compound UPa:UPC01080 ! 1,5-dihydro-coenzyme F(420) relationship: has_input_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00876 ! coenzyme F420 relationship: has_output_compound UPa:UPC00876 {cardinality="1"} ! coenzyme F420 relationship: has_output_compound UPa:UPC04488 ! 5-methyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04488 {cardinality="1"} ! 5-methyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00697 ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 1/2 relationship: part_of UPa:UER00697 {cardinality="1", direction="LR", order="1"} ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 1/2 [Term] id: UPa:UCR04467 name: 2-oxoglutarate + N-acetyl-LL-2,6-diaminopimelate = (S)-2-acetamido-6-oxopimelate + L-glutamate namespace: reaction xref: KEGG:R04467 "KEGG reaction" xref: METACYC:RXN-4822 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25318 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC04390 ! N-acetyl-LL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC04390 {cardinality="1"} ! N-acetyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC05539 ! (S)-2-acetamido-6-oxopimelate relationship: has_output_compound UPa:UPC05539 {cardinality="1"} ! (S)-2-acetamido-6-oxopimelate relationship: part_of UPa:UER00023 {cardinality="1", direction="RL", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 2/3 relationship: part_of UPa:UER00023 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 2/3 [Term] id: UPa:UCR04475 name: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate namespace: reaction xref: KEGG:R04475 "KEGG reaction" xref: METACYC:SUCCINYLDIAMINOPIMTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11963 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC04421 {cardinality="1"} ! N-succinyl-LL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC04421 ! N-succinyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC04462 ! L-2-succinylamino-6-oxopimelate relationship: has_output_compound UPa:UPC04462 {cardinality="1"} ! L-2-succinylamino-6-oxopimelate relationship: part_of UPa:UER00020 {cardinality="1", direction="RL", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3 relationship: part_of UPa:UER00020 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3 [Term] id: UPa:UCR04509 name: 4-amino-2-methyl-5-phosphomethylpyrimidine + ATP = 4-amino-2-methyl-5-diphosphomethylpyrimidine + ADP namespace: reaction xref: KEGG:R04509 "KEGG reaction" xref: METACYC:PYRIMSYN3-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19896 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC04556 {cardinality="1"} ! 4-amino-2-methyl-5-phosphomethylpyrimidine relationship: has_input_compound UPa:UPC04556 ! 4-amino-2-methyl-5-phosphomethylpyrimidine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04752 {cardinality="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: has_output_compound UPa:UPC04752 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: part_of UPa:UER00138 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3 relationship: part_of UPa:UER00138 {cardinality="1", direction="LR", order="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3 [Term] id: UPa:UCR04540 name: coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine = coenzyme B + coenzyme M + methanophenazine namespace: reaction xref: KEGG:R04540 "KEGG reaction" xref: METACYC:1.8.98.1-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18088 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04832 {cardinality="1"} ! coenzyme M-coenzyme B heterodisulfide relationship: has_input_compound UPa:UPC04832 ! coenzyme M-coenzyme B heterodisulfide relationship: has_input_compound UPa:UPC11904 {cardinality="1"} ! dihydromethanophenazine relationship: has_input_compound UPa:UPC11904 ! dihydromethanophenazine relationship: has_output_compound UPa:UPC03576 ! coenzyme M relationship: has_output_compound UPa:UPC03576 {cardinality="1"} ! coenzyme M relationship: has_output_compound UPa:UPC04628 {cardinality="1"} ! coenzyme B relationship: has_output_compound UPa:UPC04628 ! coenzyme B relationship: has_output_compound UPa:UPC11903 {cardinality="1"} ! methanophenazine relationship: has_output_compound UPa:UPC11903 ! methanophenazine relationship: part_of UPa:UER00700 {cardinality="1", direction="LR", order="1"} ! coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1 relationship: part_of UPa:UER00700 ! coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1 [Term] id: UPa:UCR04541 name: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane namespace: reaction xref: KEGG:R04541 "KEGG reaction" xref: METACYC:METHYL-COM-HTP-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12535 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03920 {cardinality="1"} ! methyl-coenzyme M relationship: has_input_compound UPa:UPC03920 ! methyl-coenzyme M relationship: has_input_compound UPa:UPC04628 {cardinality="1"} ! coenzyme B relationship: has_input_compound UPa:UPC04628 ! coenzyme B relationship: has_output_compound UPa:UPC01438 {cardinality="1"} ! methane relationship: has_output_compound UPa:UPC01438 ! methane relationship: has_output_compound UPa:UPC04832 {cardinality="1"} ! coenzyme M-coenzyme B heterodisulfide relationship: has_output_compound UPa:UPC04832 ! coenzyme M-coenzyme B heterodisulfide relationship: part_of UPa:UER00699 {cardinality="1", direction="LR", order="1"} ! methane from methyl-coenzyme M: step 1/1 relationship: part_of UPa:UER00699 ! methane from methyl-coenzyme M: step 1/1 [Term] id: UPa:UCR04549 name: H(2)O + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = UMP + lipid X namespace: reaction xref: KEGG:R04549 "KEGG reaction" xref: METACYC:LIPIDXSYNTHESIS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25216 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04652 ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_input_compound UPa:UPC04652 {cardinality="1"} ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_output_compound UPa:UPC00105 ! UMP relationship: has_output_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: has_output_compound UPa:UPC04824 ! lipid X relationship: has_output_compound UPa:UPC04824 {cardinality="1"} ! lipid X relationship: part_of UPa:UER00480 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6 relationship: part_of UPa:UER00480 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6 [Term] id: UPa:UCR04550 name: (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine = UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine + acyl-carrier protein namespace: reaction xref: KEGG:R04550 "KEGG reaction" xref: RHEA:17820 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04688 ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC04688 {cardinality="1"} ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC06022 {cardinality="1"} ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_input_compound UPa:UPC06022 ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC04652 ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_output_compound UPa:UPC04652 {cardinality="1"} ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: part_of UPa:UER00479 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6 relationship: part_of UPa:UER00479 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6 [Term] id: UPa:UCR04558 name: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + L-glutamate namespace: reaction xref: KEGG:R04558 "KEGG reaction" xref: METACYC:GLUTAMIDOTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24796 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC04916 {cardinality="1"} ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04916 ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC04666 ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_output_compound UPa:UPC04666 {cardinality="1"} ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_output_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UER00010 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9 relationship: part_of UPa:UER00010 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9 relationship: part_of UPa:UER00899 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide: step 1/1 relationship: part_of UPa:UER00899 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide: step 1/1 [Term] id: UPa:UCR04559 name: (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + fumarate namespace: reaction xref: KEGG:R04559 "KEGG reaction" xref: METACYC:AICARSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23923 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04823 ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid relationship: has_input_compound UPa:UPC04823 {cardinality="1"} ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UER00132 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2 relationship: part_of UPa:UER00132 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2 [Term] id: UPa:UCR04560 name: 10-formyl-5,6,7,8-tetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = 5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide namespace: reaction xref: KEGG:R04560 "KEGG reaction" xref: METACYC:AICARTRANSFORM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22195 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00234 ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00234 {cardinality="1"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC04734 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04734 {cardinality="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UER00133 {cardinality="1", direction="LR", order="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1 relationship: part_of UPa:UER00133 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1 [Term] id: UPa:UCR04567 name: (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + acyl-carrier protein namespace: reaction xref: KEGG:R04567 "KEGG reaction" xref: RHEA:13928 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00043 {cardinality="1"} ! UDP-N-acetyl-alpha-D-glucosamine relationship: has_input_compound UPa:UPC00043 ! UDP-N-acetyl-alpha-D-glucosamine relationship: has_input_compound UPa:UPC04688 {cardinality="1"} ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC04688 ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein relationship: has_output_compound UPa:UPC04738 ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine relationship: has_output_compound UPa:UPC04738 {cardinality="1"} ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine relationship: part_of UPa:UER00477 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6 relationship: part_of UPa:UER00477 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6 [Term] id: UPa:UCR04587 name: H(2)O + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine = UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine + acetate namespace: reaction xref: KEGG:R04587 "KEGG reaction" xref: METACYC:UDPACYLGLCNACDEACETYL-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25212 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04738 {cardinality="1"} ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine relationship: has_input_compound UPa:UPC04738 ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC06022 ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_output_compound UPa:UPC06022 {cardinality="1"} ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine relationship: part_of UPa:UER00478 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6 relationship: part_of UPa:UER00478 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6 [Term] id: UPa:UCR04591 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid + ADP + phosphate namespace: reaction xref: KEGG:R04591 "KEGG reaction" xref: METACYC:SAICARSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22631 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC04751 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_input_compound UPa:UPC04751 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC04823 ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid relationship: has_output_compound UPa:UPC04823 {cardinality="1"} ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid relationship: part_of UPa:UER00131 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2 relationship: part_of UPa:UER00131 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2 [Term] id: UPa:UCR04594 name: H(2)O + alpha-ribazole 5'-phosphate = alpha-ribazole + phosphate namespace: reaction xref: KEGG:R04594 "KEGG reaction" xref: METACYC:RIBAZOLEPHOSPHAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24459 "Rhea reaction" xref: RHEA:30370 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04778 ! alpha-ribazole 5'-phosphate relationship: has_input_compound UPa:UPC04778 {cardinality="1"} ! alpha-ribazole 5'-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC05775 {cardinality="1"} ! alpha-ribazole relationship: has_output_compound UPa:UPC05775 ! alpha-ribazole relationship: part_of UPa:UER00517 {cardinality="1", direction="LR", order="1"} ! alpha-ribazole from 5,6-dimethylbenzimidazole: step 2/2 relationship: part_of UPa:UER00517 ! alpha-ribazole from 5,6-dimethylbenzimidazole: step 2/2 [Term] id: UPa:UCR04606 name: UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine + lipid X = 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + UDP namespace: reaction xref: KEGG:R04606 "KEGG reaction" xref: METACYC:LIPIDADISACCHARIDESYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22671 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04652 {cardinality="1"} ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_input_compound UPa:UPC04652 ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_input_compound UPa:UPC04824 {cardinality="1"} ! lipid X relationship: has_input_compound UPa:UPC04824 ! lipid X relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC04932 {cardinality="1"} ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC04932 ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate relationship: part_of UPa:UER00481 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6 relationship: part_of UPa:UER00481 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6 [Term] id: UPa:UCR04621 name: 7,8-dihydroneopterin + phosphate = 7,8-dihydroneopterin 3'-phosphate + H(2)O namespace: reaction xref: KEGG:R04621 "KEGG reaction" xref: METACYC:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25309 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC04874 ! 7,8-dihydroneopterin relationship: has_input_compound UPa:UPC04874 {cardinality="1"} ! 7,8-dihydroneopterin relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC05925 {cardinality="1"} ! 7,8-dihydroneopterin 3'-phosphate relationship: has_output_compound UPa:UPC05925 ! 7,8-dihydroneopterin 3'-phosphate relationship: part_of UPa:UER00153 {cardinality="1", direction="RL", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 2/4 relationship: part_of UPa:UER00153 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 2/4 [Term] id: UPa:UCR04638 name: 7,8-dihydroneopterin triphosphate + H(2)O = 7,8-dihydroneopterin 3'-phosphate + diphosphate namespace: reaction xref: KEGG:R04638 "KEGG reaction" xref: METACYC:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25305 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04895 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate relationship: has_input_compound UPa:UPC04895 ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC05925 ! 7,8-dihydroneopterin 3'-phosphate relationship: has_output_compound UPa:UPC05925 {cardinality="1"} ! 7,8-dihydroneopterin 3'-phosphate relationship: part_of UPa:UER00152 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 1/4 relationship: part_of UPa:UER00152 {cardinality="1", direction="LR", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 1/4 [Term] id: UPa:UCR04639 name: 7,8-dihydroneopterin triphosphate + H(2)O = 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine namespace: reaction xref: KEGG:R04639 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04895 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate relationship: has_input_compound UPa:UPC04895 ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC06148 {cardinality="1"} ! 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine relationship: has_output_compound UPa:UPC06148 ! 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine relationship: part_of UPa:UER00151 {cardinality="1", direction="RL", order="4"} ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1 relationship: part_of UPa:UER00151 ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1 [Term] id: UPa:UCR04640 name: 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide = 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide namespace: reaction xref: KEGG:R04640 "KEGG reaction" xref: METACYC:PRIBFAICARPISOM-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15472 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04896 {cardinality="1"} ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04896 ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04916 ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04916 {cardinality="1"} ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: part_of UPa:UER00009 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9 relationship: part_of UPa:UER00009 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9 [Term] id: UPa:UCR04657 name: 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + ATP = ADP + lipid IV(A) namespace: reaction xref: KEGG:R04657 "KEGG reaction" xref: METACYC:TETRAACYLDISACC4KIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20703 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC04932 {cardinality="1"} ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate relationship: has_input_compound UPa:UPC04932 ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04919 {cardinality="1"} ! lipid IV(A) relationship: has_output_compound UPa:UPC04919 ! lipid IV(A) relationship: part_of UPa:UER00482 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6 relationship: part_of UPa:UER00482 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6 [Term] id: UPa:UCR04658 name: CMP-3-deoxy-D-manno-octulosonate + lipid IV(A) = 3-deoxy-D-manno-octulosonyl-lipid IV((A)) + CMP namespace: reaction xref: KEGG:R04658 "KEGG reaction" xref: METACYC:KDOTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28069 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04121 {cardinality="1"} ! CMP-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC04121 ! CMP-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC04919 {cardinality="1"} ! lipid IV(A) relationship: has_input_compound UPa:UPC04919 ! lipid IV(A) relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC06024 ! 3-deoxy-D-manno-octulosonyl-lipid IV((A)) relationship: has_output_compound UPa:UPC06024 {cardinality="1"} ! 3-deoxy-D-manno-octulosonyl-lipid IV((A)) relationship: part_of UPa:UER00483 {cardinality="1", direction="LR", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 1/4 relationship: part_of UPa:UER00483 ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 1/4 [Term] id: UPa:UCR04672 name: (S)-2-acetolactate + thiamine diphosphate = 2-hydroxyethyl-ThPP + pyruvate namespace: reaction xref: KEGG:R04672 "KEGG reaction" xref: METACYC:RXN-14037 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24808 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate relationship: has_input_compound UPa:UPC00068 ! thiamine diphosphate relationship: has_input_compound UPa:UPC06010 {cardinality="1"} ! (S)-2-acetolactate relationship: has_input_compound UPa:UPC06010 ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC05125 ! 2-hydroxyethyl-ThPP relationship: has_output_compound UPa:UPC05125 {cardinality="1"} ! 2-hydroxyethyl-ThPP relationship: part_of UPa:UER00059 {cardinality="1", direction="RL", order="2"} ! L-valine from pyruvate: step 1/4 relationship: part_of UPa:UER00059 ! L-valine from pyruvate: step 1/4 [Term] id: UPa:UCR04673 name: 2-hydroxyethyl-ThPP + 2-oxobutanoate = (S)-2-acetyl-2-hydroxybutanoic acid + thiamine diphosphate namespace: reaction xref: KEGG:R04673 "KEGG reaction" xref: RHEA:33694 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00109 ! 2-oxobutanoate relationship: has_input_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: has_input_compound UPa:UPC05125 ! 2-hydroxyethyl-ThPP relationship: has_input_compound UPa:UPC05125 {cardinality="1"} ! 2-hydroxyethyl-ThPP relationship: has_output_compound UPa:UPC00068 ! thiamine diphosphate relationship: has_output_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate relationship: has_output_compound UPa:UPC06006 {cardinality="1"} ! (S)-2-acetyl-2-hydroxybutanoic acid relationship: has_output_compound UPa:UPC06006 ! (S)-2-acetyl-2-hydroxybutanoic acid relationship: part_of UPa:UER00055 {cardinality="1", direction="LR", order="1"} ! L-isoleucine from 2-oxobutanoate: step 1/4 relationship: part_of UPa:UER00055 ! L-isoleucine from 2-oxobutanoate: step 1/4 [Term] id: UPa:UCR04692 name: (S)-coclaurine + S-adenosyl-L-methionine = (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R04692 "KEGG reaction" xref: METACYC:2.1.1.140-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17412 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06161 ! (S)-coclaurine relationship: has_input_compound UPa:UPC06161 {cardinality="1"} ! (S)-coclaurine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05176 ! (S)-N-methylcoclaurine relationship: has_output_compound UPa:UPC05176 {cardinality="1"} ! (S)-N-methylcoclaurine relationship: part_of UPa:UER00442 ! (S)-reticuline from (S)-norcoclaurine: step 2/4 relationship: part_of UPa:UER00442 {cardinality="1", direction="LR", order="1"} ! (S)-reticuline from (S)-norcoclaurine: step 2/4 [Term] id: UPa:UCR04694 name: 2 H(2)O + NADP(+) + berbamunine = (R)-N-methylcoclaurine + (S)-N-methylcoclaurine + H(+) + NADPH + O(2) namespace: reaction xref: KEGG:R04694 "KEGG reaction" xref: METACYC:1.1.3.34-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23579 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC05177 ! berbamunine relationship: has_input_compound UPa:UPC05177 {cardinality="1"} ! berbamunine relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00007 ! O(2) relationship: has_output_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05176 ! (S)-N-methylcoclaurine relationship: has_output_compound UPa:UPC05176 {cardinality="1"} ! (S)-N-methylcoclaurine relationship: has_output_compound UPa:UPC05243 {cardinality="1"} ! (R)-N-methylcoclaurine relationship: has_output_compound UPa:UPC05243 ! (R)-N-methylcoclaurine relationship: part_of UPa:UER00446 {cardinality="1", direction="RL", order="1"} ! berbamunine from (R)-N-methylcoclaurine and (S)-N-methylcoclaurine: step 1/1 relationship: part_of UPa:UER00446 ! berbamunine from (R)-N-methylcoclaurine and (S)-N-methylcoclaurine: step 1/1 [Term] id: UPa:UCR04862 name: NAD(+) + homoisocitrate = 2-oxaloglutaric acid + H(+) + NADH namespace: reaction xref: KEGG:R04862 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC05662 ! homoisocitrate relationship: has_input_compound UPa:UPC05662 {cardinality="1"} ! homoisocitrate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05533 {cardinality="1"} ! 2-oxaloglutaric acid relationship: has_output_compound UPa:UPC05533 ! 2-oxaloglutaric acid relationship: part_of UPa:UER00030 ! L-alpha-aminoadipate from 2-oxoglutarate: step 4/5 relationship: part_of UPa:UER00030 {cardinality="1", direction="LR", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 4/5 [Term] id: UPa:UCR04863 name: alpha-aminoadipoyl-C6-AMP + holo-Lys2 = AMP + alpha-aminoadipoyl-S-acyl enzyme namespace: reaction xref: KEGG:R04863 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC05560 {cardinality="1"} ! alpha-aminoadipoyl-C6-AMP relationship: has_input_compound UPa:UPC05560 ! alpha-aminoadipoyl-C6-AMP relationship: has_input_compound UPa:UPC11482 {cardinality="1"} ! holo-Lys2 relationship: has_input_compound UPa:UPC11482 ! holo-Lys2 relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC05535 {cardinality="1"} ! alpha-aminoadipoyl-S-acyl enzyme relationship: has_output_compound UPa:UPC05535 ! alpha-aminoadipoyl-S-acyl enzyme relationship: part_of UPa:UER00032 ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3 relationship: part_of UPa:UER00032 {cardinality="1", direction="LR", order="2"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3 [Term] id: UPa:UCR04868 name: H(2)O + isopenicillin N + phenylacetyl-CoA = CoA + L-alpha-aminoadipate + penicillin G namespace: reaction xref: KEGG:R04868 "KEGG reaction" xref: METACYC:2.3.1.164-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20723 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00582 ! phenylacetyl-CoA relationship: has_input_compound UPa:UPC00582 {cardinality="1"} ! phenylacetyl-CoA relationship: has_input_compound UPa:UPC05557 {cardinality="1"} ! isopenicillin N relationship: has_input_compound UPa:UPC05557 ! isopenicillin N relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC05551 {cardinality="1"} ! penicillin G relationship: has_output_compound UPa:UPC05551 ! penicillin G relationship: part_of UPa:UER00241 ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 3/3 relationship: part_of UPa:UER00241 {cardinality="1", direction="LR", order="1"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 3/3 [Term] id: UPa:UCR04870 name: 3 ATP + H(2)O + L-alpha-aminoadipate + L-cysteine + L-valine = 3 AMP + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 diphosphate namespace: reaction xref: KEGG:R04870 "KEGG reaction" xref: METACYC:6.3.2.26-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23199 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_input_compound UPa:UPC00183 {cardinality="1"} ! L-valine relationship: has_input_compound UPa:UPC00183 ! L-valine relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC05556 ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine relationship: has_output_compound UPa:UPC05556 {cardinality="1"} ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine relationship: part_of UPa:UER00239 {cardinality="1", direction="LR", order="1"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 1/3 relationship: part_of UPa:UER00239 ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 1/3 [Term] id: UPa:UCR04872 name: N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N namespace: reaction xref: KEGG:R04872 "KEGG reaction" xref: METACYC:1.21.3.1-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22431 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC05556 ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine relationship: has_input_compound UPa:UPC05556 {cardinality="1"} ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC05557 ! isopenicillin N relationship: has_output_compound UPa:UPC05557 {cardinality="1"} ! isopenicillin N relationship: part_of UPa:UER00240 {cardinality="1", direction="LR", order="1"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 2/3 relationship: part_of UPa:UER00240 ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 2/3 [Term] id: UPa:UCR05046 name: H(2)O + formamidopyrimidine nucleoside triphosphate = 2,5-diaminopyrimidine nucleoside triphosphate + formate namespace: reaction xref: KEGG:R05046 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC05922 {cardinality="1"} ! formamidopyrimidine nucleoside triphosphate relationship: has_input_compound UPa:UPC05922 ! formamidopyrimidine nucleoside triphosphate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC05923 {cardinality="1"} ! 2,5-diaminopyrimidine nucleoside triphosphate relationship: has_output_compound UPa:UPC05923 ! 2,5-diaminopyrimidine nucleoside triphosphate relationship: part_of UPa:UER00151 ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1 relationship: part_of UPa:UER00151 {cardinality="1", direction="LR", order="2"} ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1 [Term] id: UPa:UCR05048 name: 2,5-diaminopyrimidine nucleoside triphosphate = 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine namespace: reaction xref: KEGG:R05048 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC05923 {cardinality="1"} ! 2,5-diaminopyrimidine nucleoside triphosphate relationship: has_input_compound UPa:UPC05923 ! 2,5-diaminopyrimidine nucleoside triphosphate relationship: has_output_compound UPa:UPC06148 ! 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine relationship: has_output_compound UPa:UPC06148 {cardinality="1"} ! 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine relationship: part_of UPa:UER00151 ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1 relationship: part_of UPa:UER00151 {cardinality="1", direction="LR", order="3"} ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1 [Term] id: UPa:UCR05049 name: H(2)O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = H(+) + N(2)-succinyl-L-glutamic acid + NADH namespace: reaction xref: KEGG:R05049 "KEGG reaction" xref: METACYC:SUCCGLUALDDEHYD-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10815 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC05932 {cardinality="1"} ! N-succinyl-L-glutamate 5-semialdehyde relationship: has_input_compound UPa:UPC05932 ! N-succinyl-L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05931 {cardinality="1"} ! N(2)-succinyl-L-glutamic acid relationship: has_output_compound UPa:UPC05931 ! N(2)-succinyl-L-glutamic acid relationship: part_of UPa:UER00282 ! L-glutamate and succinate from L-arginine: step 4/5 relationship: part_of UPa:UER00282 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 4/5 [Term] id: UPa:UCR05068 name: (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid + NADP(+) = (R)-3-hydroxy-3-methyl-2-oxopentanoate + H(+) + NADPH namespace: reaction xref: KEGG:R05068 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC06007 ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid relationship: has_input_compound UPa:UPC06007 {cardinality="1"} ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC14463 ! (R)-3-hydroxy-3-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC14463 {cardinality="1"} ! (R)-3-hydroxy-3-methyl-2-oxopentanoate relationship: part_of UPa:UER00056 {cardinality="1", direction="RL", order="2"} ! L-isoleucine from 2-oxobutanoate: step 2/4 relationship: part_of UPa:UER00056 ! L-isoleucine from 2-oxobutanoate: step 2/4 [Term] id: UPa:UCR05069 name: (S)-2-acetyl-2-hydroxybutanoic acid = (R)-3-hydroxy-3-methyl-2-oxopentanoate namespace: reaction xref: KEGG:R05069 "KEGG reaction" xref: RHEA:25407 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06006 ! (S)-2-acetyl-2-hydroxybutanoic acid relationship: has_input_compound UPa:UPC06006 {cardinality="1"} ! (S)-2-acetyl-2-hydroxybutanoic acid relationship: has_output_compound UPa:UPC14463 ! (R)-3-hydroxy-3-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC14463 {cardinality="1"} ! (R)-3-hydroxy-3-methyl-2-oxopentanoate relationship: part_of UPa:UER00056 ! L-isoleucine from 2-oxobutanoate: step 2/4 relationship: part_of UPa:UER00056 {cardinality="1", direction="LR", order="1"} ! L-isoleucine from 2-oxobutanoate: step 2/4 [Term] id: UPa:UCR05070 name: (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid = (S)-3-methyl-2-oxopentanoate + H(2)O namespace: reaction xref: KEGG:R05070 "KEGG reaction" xref: METACYC:DIHYDROXYMETVALDEHYDRAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:27697 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06007 ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid relationship: has_input_compound UPa:UPC06007 {cardinality="1"} ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00671 ! (S)-3-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00671 {cardinality="1"} ! (S)-3-methyl-2-oxopentanoate relationship: part_of UPa:UER00057 ! L-isoleucine from 2-oxobutanoate: step 3/4 relationship: part_of UPa:UER00057 {cardinality="1", direction="LR", order="1"} ! L-isoleucine from 2-oxobutanoate: step 3/4 [Term] id: UPa:UCR05071 name: (S)-2-acetolactate = 2-oxo-3-hydroxyisovalerate namespace: reaction xref: KEGG:R05071 "KEGG reaction" xref: METACYC:2-ACETOLACTATE-MUTASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:31258 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06010 ! (S)-2-acetolactate relationship: has_input_compound UPa:UPC06010 {cardinality="1"} ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC04181 ! 2-oxo-3-hydroxyisovalerate relationship: has_output_compound UPa:UPC04181 {cardinality="1"} ! 2-oxo-3-hydroxyisovalerate relationship: part_of UPa:UER00060 {cardinality="1", direction="LR", order="1"} ! L-valine from pyruvate: step 2/4 relationship: part_of UPa:UER00060 ! L-valine from pyruvate: step 2/4 [Term] id: UPa:UCR05074 name: 3-deoxy-D-manno-octulosonyl-lipid IV((A)) + CMP-3-deoxy-D-manno-octulosonate = CMP + di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) namespace: reaction xref: KEGG:R05074 "KEGG reaction" xref: METACYC:KDOTRANS2-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28065 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04121 ! CMP-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC04121 {cardinality="1"} ! CMP-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC06024 {cardinality="1"} ! 3-deoxy-D-manno-octulosonyl-lipid IV((A)) relationship: has_input_compound UPa:UPC06024 ! 3-deoxy-D-manno-octulosonyl-lipid IV((A)) relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC06025 ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) relationship: has_output_compound UPa:UPC06025 {cardinality="1"} ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) relationship: part_of UPa:UER00484 ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 2/4 relationship: part_of UPa:UER00484 {cardinality="1", direction="LR", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 2/4 [Term] id: UPa:UCR05075 name: lauroyl-KDO(2)-lipid IV(A) + tetradecanoyl-[acp] = KDO(2)-lipid A + acyl-carrier protein namespace: reaction xref: KEGG:R05075 "KEGG reaction" xref: RHEA:28441 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC05761 {cardinality="1"} ! tetradecanoyl-[acp] relationship: has_input_compound UPa:UPC05761 ! tetradecanoyl-[acp] relationship: has_input_compound UPa:UPC06251 ! lauroyl-KDO(2)-lipid IV(A) relationship: has_input_compound UPa:UPC06251 {cardinality="1"} ! lauroyl-KDO(2)-lipid IV(A) relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC06026 ! KDO(2)-lipid A relationship: has_output_compound UPa:UPC06026 {cardinality="1"} ! KDO(2)-lipid A relationship: part_of UPa:UER00486 ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4 relationship: part_of UPa:UER00486 {cardinality="1", direction="LR", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4 [Term] id: UPa:UCR05085 name: 2-oxoglutarate + 4-(phosphonooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid + L-glutamate namespace: reaction xref: KEGG:R05085 "KEGG reaction" xref: METACYC:PSERTRANSAMPYR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16576 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06055 {cardinality="1"} ! 4-(phosphonooxy)-L-threonine relationship: has_input_compound UPa:UPC06055 ! 4-(phosphonooxy)-L-threonine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC06054 {cardinality="1"} ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid relationship: has_output_compound UPa:UPC06054 ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid relationship: part_of UPa:UER00311 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5 relationship: part_of UPa:UER00311 {cardinality="1", direction="RL", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5 [Term] id: UPa:UCR05123 name: (S)-norcoclaurine + S-adenosyl-L-methionine = (S)-coclaurine + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R05123 "KEGG reaction" xref: METACYC:2.1.1.128-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:31910 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06160 ! (S)-norcoclaurine relationship: has_input_compound UPa:UPC06160 {cardinality="1"} ! (S)-norcoclaurine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06161 ! (S)-coclaurine relationship: has_output_compound UPa:UPC06161 {cardinality="1"} ! (S)-coclaurine relationship: part_of UPa:UER00441 ! (S)-reticuline from (S)-norcoclaurine: step 1/4 relationship: part_of UPa:UER00441 {cardinality="1", direction="LR", order="1"} ! (S)-reticuline from (S)-norcoclaurine: step 1/4 [Term] id: UPa:UCR05146 name: di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) + dodecanoyl-[acyl-carrier protein] = acyl-carrier protein + lauroyl-KDO(2)-lipid IV(A) namespace: reaction xref: KEGG:R05146 "KEGG reaction" xref: RHEA:28445 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC05223 ! dodecanoyl-[acyl-carrier protein] relationship: has_input_compound UPa:UPC05223 {cardinality="1"} ! dodecanoyl-[acyl-carrier protein] relationship: has_input_compound UPa:UPC06025 {cardinality="1"} ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) relationship: has_input_compound UPa:UPC06025 ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC06251 {cardinality="1"} ! lauroyl-KDO(2)-lipid IV(A) relationship: has_output_compound UPa:UPC06251 ! lauroyl-KDO(2)-lipid IV(A) relationship: part_of UPa:UER00485 ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 3/4 relationship: part_of UPa:UER00485 {cardinality="1", direction="LR", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 3/4 [Term] id: UPa:UCR05149 name: 2 S-adenosyl-L-methionine + precorrin-6B = CO(2) + 2 S-adenosyl-L-homocysteine + precorrin-8X namespace: reaction xref: KEGG:R05149 "KEGG reaction" xref: METACYC:2.1.1.132-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17480 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06319 {cardinality="1"} ! precorrin-6B relationship: has_input_compound UPa:UPC06319 ! precorrin-6B relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06408 {cardinality="1"} ! precorrin-8X relationship: has_output_compound UPa:UPC06408 ! precorrin-8X relationship: part_of UPa:UER00218 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 7/10 relationship: part_of UPa:UER00218 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 7/10 [Term] id: UPa:UCR05150 name: NADP(+) + precorrin-6B = H(+) + NADPH + precorrin-6A namespace: reaction xref: KEGG:R05150 "KEGG reaction" xref: METACYC:1.3.1.54-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23411 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC06319 {cardinality="1"} ! precorrin-6B relationship: has_input_compound UPa:UPC06319 ! precorrin-6B relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC06320 {cardinality="1"} ! precorrin-6A relationship: has_output_compound UPa:UPC06320 ! precorrin-6A relationship: part_of UPa:UER00217 {cardinality="1", direction="RL", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 6/10 relationship: part_of UPa:UER00217 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 6/10 [Term] id: UPa:UCR05176 name: ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose namespace: reaction xref: KEGG:R05176 "KEGG reaction" xref: METACYC:5.1.3.20-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17580 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06397 ! ADP-D-glycero-beta-D-manno-heptose relationship: has_input_compound UPa:UPC06397 {cardinality="1"} ! ADP-D-glycero-beta-D-manno-heptose relationship: has_output_compound UPa:UPC06398 {cardinality="1"} ! ADP-L-glycero-beta-D-manno-heptose relationship: has_output_compound UPa:UPC06398 ! ADP-L-glycero-beta-D-manno-heptose relationship: part_of UPa:UER00440 ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4 relationship: part_of UPa:UER00440 {cardinality="1", direction="LR", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4 [Term] id: UPa:UCR05177 name: precorrin-8X = hydrogenobyrinic acid namespace: reaction xref: KEGG:R05177 "KEGG reaction" xref: METACYC:5.4.1.2-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22515 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06408 ! precorrin-8X relationship: has_input_compound UPa:UPC06408 {cardinality="1"} ! precorrin-8X relationship: has_output_compound UPa:UPC06399 {cardinality="1"} ! hydrogenobyrinic acid relationship: has_output_compound UPa:UPC06399 ! hydrogenobyrinic acid relationship: part_of UPa:UER00219 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 8/10 relationship: part_of UPa:UER00219 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 8/10 [Term] id: UPa:UCR05180 name: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4 namespace: reaction xref: KEGG:R05180 "KEGG reaction" xref: METACYC:2.1.1.131-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12764 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06406 ! precorrin-3B relationship: has_input_compound UPa:UPC06406 {cardinality="1"} ! precorrin-3B relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06407 ! precorrin-4 relationship: has_output_compound UPa:UPC06407 {cardinality="1"} ! precorrin-4 relationship: part_of UPa:UER00214 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 3/10 relationship: part_of UPa:UER00214 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 3/10 [Term] id: UPa:UCR05181 name: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5 namespace: reaction xref: KEGG:R05181 "KEGG reaction" xref: METACYC:2.1.1.133-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22015 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06407 ! precorrin-4 relationship: has_input_compound UPa:UPC06407 {cardinality="1"} ! precorrin-4 relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06416 ! precorrin-5 relationship: has_output_compound UPa:UPC06416 {cardinality="1"} ! precorrin-5 relationship: part_of UPa:UER00215 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 4/10 relationship: part_of UPa:UER00215 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 4/10 [Term] id: UPa:UCR05217 name: H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B namespace: reaction xref: KEGG:R05217 "KEGG reaction" xref: METACYC:R321-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17296 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC05772 {cardinality="1"} ! precorrin-3A relationship: has_input_compound UPa:UPC05772 ! precorrin-3A relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC06406 ! precorrin-3B relationship: has_output_compound UPa:UPC06406 {cardinality="1"} ! precorrin-3B relationship: part_of UPa:UER00213 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 2/10 relationship: part_of UPa:UER00213 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 2/10 [Term] id: UPa:UCR05218 name: FMNH(2) + 2 cob(II)yrinate a,c-diamide = FMN + 2 H(+) + 2 cob(I)yrinic acid a,c-diamide namespace: reaction xref: KEGG:R05218 "KEGG reaction" xref: METACYC:R343-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24303 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01847 {cardinality="1"} ! FMNH(2) relationship: has_input_compound UPa:UPC01847 ! FMNH(2) relationship: has_input_compound UPa:UPC06504 {cardinality="1"} ! cob(II)yrinate a,c-diamide relationship: has_input_compound UPa:UPC06504 ! cob(II)yrinate a,c-diamide relationship: has_output_compound UPa:UPC00061 ! FMN relationship: has_output_compound UPa:UPC00061 {cardinality="1"} ! FMN relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC06505 {cardinality="1"} ! cob(I)yrinic acid a,c-diamide relationship: has_output_compound UPa:UPC06505 ! cob(I)yrinic acid a,c-diamide relationship: part_of UPa:UER00232 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 1/7 relationship: part_of UPa:UER00232 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 1/7 [Term] id: UPa:UCR05219 name: S-adenosyl-L-homocysteine + acetate + precorrin-6A = H(2)O + S-adenosyl-L-methionine + precorrin-5 namespace: reaction xref: KEGG:R05219 "KEGG reaction" xref: METACYC:R322-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18264 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_input_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_input_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_input_compound UPa:UPC00033 ! acetate relationship: has_input_compound UPa:UPC06320 {cardinality="1"} ! precorrin-6A relationship: has_input_compound UPa:UPC06320 ! precorrin-6A relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_output_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_output_compound UPa:UPC06416 ! precorrin-5 relationship: has_output_compound UPa:UPC06416 {cardinality="1"} ! precorrin-5 relationship: part_of UPa:UER00216 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 5/10 relationship: part_of UPa:UER00216 {cardinality="1", direction="RL", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 5/10 [Term] id: UPa:UCR05220 name: ATP + cob(I)yrinic acid a,c-diamide = adenosylcob(III)yrinic acid a,c-diamide + triphosphate namespace: reaction xref: KEGG:R05220 "KEGG reaction" xref: METACYC:R344-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11531 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC06505 ! cob(I)yrinic acid a,c-diamide relationship: has_input_compound UPa:UPC06505 {cardinality="1"} ! cob(I)yrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00536 {cardinality="1"} ! triphosphate relationship: has_output_compound UPa:UPC00536 ! triphosphate relationship: has_output_compound UPa:UPC06506 ! adenosylcob(III)yrinic acid a,c-diamide relationship: has_output_compound UPa:UPC06506 {cardinality="1"} ! adenosylcob(III)yrinic acid a,c-diamide relationship: part_of UPa:UER00233 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7 relationship: part_of UPa:UER00233 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7 [Term] id: UPa:UCR05221 name: ATP + adenosylcobinamide = ADP + adenosylcobinamide phosphate namespace: reaction xref: KEGG:R05221 "KEGG reaction" xref: METACYC:COBINAMIDEKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15772 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC06508 {cardinality="1"} ! adenosylcobinamide relationship: has_input_compound UPa:UPC06508 ! adenosylcobinamide relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC06509 ! adenosylcobinamide phosphate relationship: has_output_compound UPa:UPC06509 {cardinality="1"} ! adenosylcobinamide phosphate relationship: part_of UPa:UER00953 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00953 ! None [Term] id: UPa:UCR05222 name: GTP + adenosylcobinamide phosphate = adenosylcobinamide-GDP + diphosphate namespace: reaction xref: KEGG:R05222 "KEGG reaction" xref: METACYC:COBINPGUANYLYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22715 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC06509 {cardinality="1"} ! adenosylcobinamide phosphate relationship: has_input_compound UPa:UPC06509 ! adenosylcobinamide phosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC06510 ! adenosylcobinamide-GDP relationship: has_output_compound UPa:UPC06510 {cardinality="1"} ! adenosylcobinamide-GDP relationship: part_of UPa:UER00237 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7 relationship: part_of UPa:UER00237 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7 [Term] id: UPa:UCR05223 name: GMP + adenosylcobalamin = adenosylcobinamide-GDP + alpha-ribazole namespace: reaction xref: KEGG:R05223 "KEGG reaction" xref: METACYC:COBALAMINSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16052 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: has_input_compound UPa:UPC00144 ! GMP relationship: has_input_compound UPa:UPC00194 ! adenosylcobalamin relationship: has_input_compound UPa:UPC00194 {cardinality="1"} ! adenosylcobalamin relationship: has_output_compound UPa:UPC05775 ! alpha-ribazole relationship: has_output_compound UPa:UPC05775 {cardinality="1"} ! alpha-ribazole relationship: has_output_compound UPa:UPC06510 ! adenosylcobinamide-GDP relationship: has_output_compound UPa:UPC06510 {cardinality="1"} ! adenosylcobinamide-GDP relationship: part_of UPa:UER00238 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7 relationship: part_of UPa:UER00238 {cardinality="1", direction="RL", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7 [Term] id: UPa:UCR05224 name: 2 ATP + 2 H(2)O + 2 L-glutamine + hydrogenobyrinic acid = 2 ADP + 2 L-glutamate + hydrogenobyrinic acid a,c-diamide + 2 phosphate namespace: reaction xref: KEGG:R05224 "KEGG reaction" xref: METACYC:R341-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12547 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC06399 ! hydrogenobyrinic acid relationship: has_input_compound UPa:UPC06399 {cardinality="1"} ! hydrogenobyrinic acid relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC06503 ! hydrogenobyrinic acid a,c-diamide relationship: has_output_compound UPa:UPC06503 {cardinality="1"} ! hydrogenobyrinic acid a,c-diamide relationship: part_of UPa:UER00220 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10 relationship: part_of UPa:UER00220 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10 [Term] id: UPa:UCR05225 name: 4 ATP + 4 H(2)O + 4 L-glutamine + adenosylcob(III)yrinic acid a,c-diamide = 4 ADP + 4 L-glutamate + adenosylcobyrinic acid a,c-diamide + 4 phosphate namespace: reaction xref: KEGG:R05225 "KEGG reaction" xref: METACYC:R345-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23259 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC06506 {cardinality="1"} ! adenosylcob(III)yrinic acid a,c-diamide relationship: has_input_compound UPa:UPC06506 ! adenosylcob(III)yrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC06507 ! adenosylcobyrinic acid a,c-diamide relationship: has_output_compound UPa:UPC06507 {cardinality="1"} ! adenosylcobyrinic acid a,c-diamide relationship: part_of UPa:UER00234 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 3/7 relationship: part_of UPa:UER00234 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 3/7 [Term] id: UPa:UCR05226 name: (R)-1-aminopropan-2-ol + adenosylcobyrinic acid a,c-diamide = H(2)O + adenosylcobinamide namespace: reaction xref: KEGG:R05226 "KEGG reaction" xref: METACYC:R346-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23507 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03194 {cardinality="1"} ! (R)-1-aminopropan-2-ol relationship: has_input_compound UPa:UPC03194 ! (R)-1-aminopropan-2-ol relationship: has_input_compound UPa:UPC06507 {cardinality="1"} ! adenosylcobyrinic acid a,c-diamide relationship: has_input_compound UPa:UPC06507 ! adenosylcobyrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC06508 ! adenosylcobinamide relationship: has_output_compound UPa:UPC06508 {cardinality="1"} ! adenosylcobinamide relationship: part_of UPa:UER00235 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 4/7 relationship: part_of UPa:UER00235 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 4/7 [Term] id: UPa:UCR05227 name: ATP + Co(2+) + H(2)O + hydrogenobyrinic acid a,c-diamide = ADP + H(+) + cob(II)yrinate a,c-diamide + phosphate namespace: reaction xref: KEGG:R05227 "KEGG reaction" xref: METACYC:R342-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15344 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00175 ! Co(2+) relationship: has_input_compound UPa:UPC00175 {cardinality="1"} ! Co(2+) relationship: has_input_compound UPa:UPC06503 {cardinality="1"} ! hydrogenobyrinic acid a,c-diamide relationship: has_input_compound UPa:UPC06503 ! hydrogenobyrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC06504 ! cob(II)yrinate a,c-diamide relationship: has_output_compound UPa:UPC06504 {cardinality="1"} ! cob(II)yrinate a,c-diamide relationship: part_of UPa:UER00221 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 10/10 relationship: part_of UPa:UER00221 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 10/10 [Term] id: UPa:UCR05239 name: NAD(+) + cis-3-phenylcyclohexa-3,5-diene-1,2-diol = H(+) + NADH + biphenyl-2,3-diol namespace: reaction xref: KEGG:R05239 "KEGG reaction" xref: METACYC:1.3.1.56-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17036 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC06589 {cardinality="1"} ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol relationship: has_input_compound UPa:UPC06589 ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC02526 ! biphenyl-2,3-diol relationship: has_output_compound UPa:UPC02526 {cardinality="1"} ! biphenyl-2,3-diol relationship: part_of UPa:UER00251 ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 2/4 relationship: part_of UPa:UER00251 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 2/4 [Term] id: UPa:UCR05240 name: NAD(+) + cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid = 2,3-dihydroxy-p-cumic acid + H(+) + NADH namespace: reaction xref: KEGG:R05240 "KEGG reaction" xref: METACYC:RXN-665 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23775 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC06579 {cardinality="1"} ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid relationship: has_input_compound UPa:UPC06579 ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC06580 ! 2,3-dihydroxy-p-cumic acid relationship: has_output_compound UPa:UPC06580 {cardinality="1"} ! 2,3-dihydroxy-p-cumic acid relationship: part_of UPa:UER00902 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 2/7 relationship: part_of UPa:UER00902 ! acetaldehyde and pyruvate from p-cumate: step 2/7 [Term] id: UPa:UCR05247 name: H(+) + NADH + O(2) + p-cumate = NAD(+) + cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid namespace: reaction xref: KEGG:R05247 "KEGG reaction" xref: METACYC:RXN-664 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42347 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC06578 {cardinality="1"} ! p-cumate relationship: has_input_compound UPa:UPC06578 ! p-cumate relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC06579 ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid relationship: has_output_compound UPa:UPC06579 {cardinality="1"} ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid relationship: part_of UPa:UER00901 ! acetaldehyde and pyruvate from p-cumate: step 1/7 relationship: part_of UPa:UER00901 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 1/7 [Term] id: UPa:UCR05248 name: 2,3-dihydroxy-p-cumic acid + O(2) = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid namespace: reaction xref: KEGG:R05248 "KEGG reaction" xref: METACYC:RXN-666 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42571 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC06580 ! 2,3-dihydroxy-p-cumic acid relationship: has_input_compound UPa:UPC06580 {cardinality="1"} ! 2,3-dihydroxy-p-cumic acid relationship: has_output_compound UPa:UPC06581 ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_output_compound UPa:UPC06581 {cardinality="1"} ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: part_of UPa:UER00903 ! acetaldehyde and pyruvate from p-cumate: step 3/7 relationship: part_of UPa:UER00903 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 3/7 [Term] id: UPa:UCR05263 name: H(+) + NADH + O(2) + biphenyl = NAD(+) + cis-3-phenylcyclohexa-3,5-diene-1,2-diol namespace: reaction xref: KEGG:R05263 "KEGG reaction" xref: METACYC:1.14.12.18-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18168 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC06588 ! biphenyl relationship: has_input_compound UPa:UPC06588 {cardinality="1"} ! biphenyl relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC06589 ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol relationship: has_output_compound UPa:UPC06589 {cardinality="1"} ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol relationship: part_of UPa:UER00250 ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 1/4 relationship: part_of UPa:UER00250 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 1/4 [Term] id: UPa:UCR05275 name: NAD(+) + cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid = 4,5-dihydroxyphthalate + H(+) + NADH namespace: reaction xref: KEGG:R05275 "KEGG reaction" xref: METACYC:1.3.1.64-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13840 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC04783 ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid relationship: has_input_compound UPa:UPC04783 {cardinality="1"} ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC03233 ! 4,5-dihydroxyphthalate relationship: has_output_compound UPa:UPC03233 {cardinality="1"} ! 4,5-dihydroxyphthalate relationship: part_of UPa:UER00729 ! 3,4-dihydroxybenzoate from phthalate: step 2/3 relationship: part_of UPa:UER00729 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from phthalate: step 2/3 [Term] id: UPa:UCR05284 name: 1,2-dichloroethane + H(2)O = 2-chloroethanol + HCl namespace: reaction xref: KEGG:R05284 "KEGG reaction" xref: METACYC:DHLAXANAU-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25188 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06752 {cardinality="1"} ! 1,2-dichloroethane relationship: has_input_compound UPa:UPC06752 ! 1,2-dichloroethane relationship: has_output_compound UPa:UPC01327 {cardinality="1"} ! HCl relationship: has_output_compound UPa:UPC01327 ! HCl relationship: has_output_compound UPa:UPC06753 ! 2-chloroethanol relationship: has_output_compound UPa:UPC06753 {cardinality="1"} ! 2-chloroethanol relationship: part_of UPa:UER00387 {cardinality="1", direction="LR", order="1"} ! glycolate from 1,2-dichloroethane: step 1/4 relationship: part_of UPa:UER00387 ! glycolate from 1,2-dichloroethane: step 1/4 [Term] id: UPa:UCR05285 name: 2-chloroethanol + 2 ferricytochrome c = 2 H(+) + chloroacetaldehyde + 2 ferrocytochrome c namespace: reaction xref: KEGG:R05285 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00125 ! ferricytochrome c relationship: has_input_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c relationship: has_input_compound UPa:UPC06753 {cardinality="1"} ! 2-chloroethanol relationship: has_input_compound UPa:UPC06753 ! 2-chloroethanol relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c relationship: has_output_compound UPa:UPC00126 ! ferrocytochrome c relationship: has_output_compound UPa:UPC06754 ! chloroacetaldehyde relationship: has_output_compound UPa:UPC06754 {cardinality="1"} ! chloroacetaldehyde relationship: part_of UPa:UER00388 {cardinality="1", direction="LR", order="1"} ! glycolate from 1,2-dichloroethane: step 2/4 relationship: part_of UPa:UER00388 ! glycolate from 1,2-dichloroethane: step 2/4 [Term] id: UPa:UCR05286 name: H(2)O + NAD(+) + chloroacetaldehyde = H(+) + NADH + chloroacetic acid namespace: reaction xref: KEGG:R05286 "KEGG reaction" xref: METACYC:ALDXANAU-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:30050 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC06754 {cardinality="1"} ! chloroacetaldehyde relationship: has_input_compound UPa:UPC06754 ! chloroacetaldehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC06755 ! chloroacetic acid relationship: has_output_compound UPa:UPC06755 {cardinality="1"} ! chloroacetic acid relationship: part_of UPa:UER00389 ! glycolate from 1,2-dichloroethane: step 3/4 relationship: part_of UPa:UER00389 {cardinality="1", direction="LR", order="1"} ! glycolate from 1,2-dichloroethane: step 3/4 [Term] id: UPa:UCR05287 name: H(2)O + chloroacetic acid = HCl + glycolate namespace: reaction xref: KEGG:R05287 "KEGG reaction" xref: METACYC:DHLBXANAU-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25192 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC06755 ! chloroacetic acid relationship: has_input_compound UPa:UPC06755 {cardinality="1"} ! chloroacetic acid relationship: has_output_compound UPa:UPC00160 {cardinality="1"} ! glycolate relationship: has_output_compound UPa:UPC00160 ! glycolate relationship: has_output_compound UPa:UPC01327 {cardinality="1"} ! HCl relationship: has_output_compound UPa:UPC01327 ! HCl relationship: part_of UPa:UER00390 ! glycolate from 1,2-dichloroethane: step 4/4 relationship: part_of UPa:UER00390 {cardinality="1", direction="LR", order="1"} ! glycolate from 1,2-dichloroethane: step 4/4 [Term] id: UPa:UCR05320 name: 2-oxoglutarate + O(2) + taurine = CO(2) + aminoacetaldehyde + succinate + sulfite namespace: reaction xref: KEGG:R05320 "KEGG reaction" xref: METACYC:RXN0-299 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15912 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00245 ! taurine relationship: has_input_compound UPa:UPC00245 {cardinality="1"} ! taurine relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_output_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC06735 ! aminoacetaldehyde relationship: has_output_compound UPa:UPC06735 {cardinality="1"} ! aminoacetaldehyde relationship: part_of UPa:UER00542 {cardinality="1", direction="LR", order="1"} ! aminoacetaldehyde and sulfite from taurine: step 1/1 relationship: part_of UPa:UER00542 ! aminoacetaldehyde and sulfite from taurine: step 1/1 [Term] id: UPa:UCR05332 name: acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate namespace: reaction xref: KEGG:R05332 "KEGG reaction" xref: METACYC:2.3.1.157-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13728 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC06156 ! alpha-D-glucosamine 1-phosphate relationship: has_input_compound UPa:UPC06156 {cardinality="1"} ! alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC04501 {cardinality="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC04501 ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: part_of UPa:UER00532 ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2 relationship: part_of UPa:UER00532 {cardinality="1", direction="LR", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2 [Term] id: UPa:UCR05338 name: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate namespace: reaction xref: KEGG:R05338 "KEGG reaction" xref: METACYC:R10-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25204 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00067 ! formaldehyde relationship: has_input_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC06019 {cardinality="1"} ! D-arabino-3-hexulose 6-phosphate relationship: has_output_compound UPa:UPC06019 ! D-arabino-3-hexulose 6-phosphate relationship: part_of UPa:UER00434 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 1/2 relationship: part_of UPa:UER00434 ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 1/2 [Term] id: UPa:UCR05339 name: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate namespace: reaction xref: KEGG:R05339 "KEGG reaction" xref: METACYC:R12-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25903 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06019 {cardinality="1"} ! D-arabino-3-hexulose 6-phosphate relationship: has_input_compound UPa:UPC06019 ! D-arabino-3-hexulose 6-phosphate relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: part_of UPa:UER00435 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 2/2 relationship: part_of UPa:UER00435 ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 2/2 [Term] id: UPa:UCR05357 name: H(2)O + amidinoproclavaminic acid = proclavaminic acid + urea namespace: reaction xref: KEGG:R05357 "KEGG reaction" xref: METACYC:3.5.3.22-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17004 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC06657 {cardinality="1"} ! amidinoproclavaminic acid relationship: has_input_compound UPa:UPC06657 ! amidinoproclavaminic acid relationship: has_output_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_output_compound UPa:UPC06658 ! proclavaminic acid relationship: has_output_compound UPa:UPC06658 {cardinality="1"} ! proclavaminic acid relationship: part_of UPa:UER00245 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 4/8 relationship: part_of UPa:UER00245 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 4/8 [Term] id: UPa:UCR05360 name: 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid + H(2)O = 2-hydroxy-2,4-pentadienoate + salicylate namespace: reaction xref: KEGG:R05360 "KEGG reaction" xref: METACYC:R608-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42471 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC07731 ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_input_compound UPa:UPC07731 {cardinality="1"} ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_output_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00805 ! salicylate relationship: has_output_compound UPa:UPC00805 {cardinality="1"} ! salicylate relationship: part_of UPa:UER00778 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 3/3 relationship: part_of UPa:UER00778 ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 3/3 [Term] id: UPa:UCR05361 name: 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid + H(2)O = 2-hydroxymuconate + catechol namespace: reaction xref: KEGG:R05361 "KEGG reaction" xref: RHEA:42483 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC07734 ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_input_compound UPa:UPC07734 {cardinality="1"} ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_output_compound UPa:UPC00090 ! catechol relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: has_output_compound UPa:UPC02501 {cardinality="1"} ! 2-hydroxymuconate relationship: has_output_compound UPa:UPC02501 ! 2-hydroxymuconate relationship: part_of UPa:UER00781 {cardinality="1", direction="LR", order="1"} ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 3/3 relationship: part_of UPa:UER00781 ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 3/3 [Term] id: UPa:UCR05364 name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid + H(2)O = 2-hydroxy-2,4-pentadienoate + 2-methylpropanoate namespace: reaction xref: KEGG:R05364 "KEGG reaction" xref: METACYC:RXN-668 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:42579 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06582 {cardinality="1"} ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_input_compound UPa:UPC06582 ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_output_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC02632 ! 2-methylpropanoate relationship: has_output_compound UPa:UPC02632 {cardinality="1"} ! 2-methylpropanoate relationship: part_of UPa:UER00905 ! acetaldehyde and pyruvate from p-cumate: step 5/7 relationship: part_of UPa:UER00905 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 5/7 [Term] id: UPa:UCR05377 name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid = 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid + CO(2) namespace: reaction xref: KEGG:R05377 "KEGG reaction" xref: METACYC:RXN-667 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:42575 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06581 {cardinality="1"} ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_input_compound UPa:UPC06581 ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC06582 {cardinality="1"} ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_output_compound UPa:UPC06582 ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: part_of UPa:UER00904 ! acetaldehyde and pyruvate from p-cumate: step 4/7 relationship: part_of UPa:UER00904 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 4/7 [Term] id: UPa:UCR05378 name: 6-phospho-5-dehydro-2-deoxy-D-gluconic acid = 3-oxopropanoate + glycerone phosphate namespace: reaction xref: KEGG:R05378 "KEGG reaction" xref: METACYC:4.1.2.29-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13180 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06893 ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid relationship: has_input_compound UPa:UPC06893 {cardinality="1"} ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00222 {cardinality="1"} ! 3-oxopropanoate relationship: has_output_compound UPa:UPC00222 ! 3-oxopropanoate relationship: part_of UPa:UER00147 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 6/7 relationship: part_of UPa:UER00147 ! acetyl-CoA from myo-inositol: step 6/7 [Term] id: UPa:UCR05411 name: O(2) + biphenyl-2,2',3-triol = 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid namespace: reaction xref: KEGG:R05411 "KEGG reaction" xref: METACYC:R607-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42467 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC03569 {cardinality="1"} ! biphenyl-2,2',3-triol relationship: has_input_compound UPa:UPC03569 ! biphenyl-2,2',3-triol relationship: has_output_compound UPa:UPC07731 ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_output_compound UPa:UPC07731 {cardinality="1"} ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: part_of UPa:UER00777 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 2/3 relationship: part_of UPa:UER00777 ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 2/3 [Term] id: UPa:UCR05413 name: 2,2',3-trihydroxy-diphenyl ether + O(2) = 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid namespace: reaction xref: KEGG:R05413 "KEGG reaction" xref: METACYC:R604-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42479 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC07733 ! 2,2',3-trihydroxy-diphenyl ether relationship: has_input_compound UPa:UPC07733 {cardinality="1"} ! 2,2',3-trihydroxy-diphenyl ether relationship: has_output_compound UPa:UPC07734 ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_output_compound UPa:UPC07734 {cardinality="1"} ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: part_of UPa:UER00780 ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 2/3 relationship: part_of UPa:UER00780 {cardinality="1", direction="LR", order="1"} ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 2/3 [Term] id: UPa:UCR05434 name: H(+) + NADH + O(2) + dibenzofuran = NAD(+) + biphenyl-2,2',3-triol namespace: reaction xref: KEGG:R05434 "KEGG reaction" xref: METACYC:R606-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42463 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC07729 {cardinality="1"} ! dibenzofuran relationship: has_input_compound UPa:UPC07729 ! dibenzofuran relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC03569 {cardinality="1"} ! biphenyl-2,2',3-triol relationship: has_output_compound UPa:UPC03569 ! biphenyl-2,2',3-triol relationship: part_of UPa:UER00776 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 1/3 relationship: part_of UPa:UER00776 ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 1/3 [Term] id: UPa:UCR05439 name: H(+) + NADH + O(2) + dibenzo-p-dioxin = 2,2',3-trihydroxy-diphenyl ether + NAD(+) namespace: reaction xref: KEGG:R05439 "KEGG reaction" xref: RHEA:42475 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC07732 ! dibenzo-p-dioxin relationship: has_input_compound UPa:UPC07732 {cardinality="1"} ! dibenzo-p-dioxin relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC07733 ! 2,2',3-trihydroxy-diphenyl ether relationship: has_output_compound UPa:UPC07733 {cardinality="1"} ! 2,2',3-trihydroxy-diphenyl ether relationship: part_of UPa:UER00779 ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 1/3 relationship: part_of UPa:UER00779 {cardinality="1", direction="LR", order="1"} ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 1/3 [Term] id: UPa:UCR05465 name: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + phosphate namespace: reaction xref: KEGG:R05465 "KEGG reaction" xref: METACYC:2.5.1.66-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10559 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC06655 {cardinality="1"} ! N(2)-(2-carboxyethyl)-L-arginine relationship: has_output_compound UPa:UPC06655 ! N(2)-(2-carboxyethyl)-L-arginine relationship: part_of UPa:UER00242 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 1/8 relationship: part_of UPa:UER00242 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 1/8 [Term] id: UPa:UCR05466 name: 2-oxoglutarate + O(2) + deoxyamidinoproclavaminic acid = CO(2) + amidinoproclavaminic acid + succinate namespace: reaction xref: KEGG:R05466 "KEGG reaction" xref: METACYC:1.14.11.21-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20024 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06656 {cardinality="1"} ! deoxyamidinoproclavaminic acid relationship: has_input_compound UPa:UPC06656 ! deoxyamidinoproclavaminic acid relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC06657 {cardinality="1"} ! amidinoproclavaminic acid relationship: has_output_compound UPa:UPC06657 ! amidinoproclavaminic acid relationship: part_of UPa:UER00244 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 3/8 relationship: part_of UPa:UER00244 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 3/8 [Term] id: UPa:UCR05467 name: ATP + N(2)-(2-carboxyethyl)-L-arginine = AMP + deoxyamidinoproclavaminic acid + diphosphate namespace: reaction xref: KEGG:R05467 "KEGG reaction" xref: METACYC:6.3.3.4-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23623 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC06655 {cardinality="1"} ! N(2)-(2-carboxyethyl)-L-arginine relationship: has_input_compound UPa:UPC06655 ! N(2)-(2-carboxyethyl)-L-arginine relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC06656 {cardinality="1"} ! deoxyamidinoproclavaminic acid relationship: has_output_compound UPa:UPC06656 ! deoxyamidinoproclavaminic acid relationship: part_of UPa:UER00243 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 2/8 relationship: part_of UPa:UER00243 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 2/8 [Term] id: UPa:UCR05468 name: 2-oxoglutarate + O(2) + proclavaminic acid = CO(2) + H(2)O + dihydroclavaminic acid + succinate namespace: reaction xref: KEGG:R05468 "KEGG reaction" xref: METACYC:RXN-6266 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12776 "Rhea reaction" xref: RHEA:19788 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06658 {cardinality="1"} ! proclavaminic acid relationship: has_input_compound UPa:UPC06658 ! proclavaminic acid relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC06659 {cardinality="1"} ! dihydroclavaminic acid relationship: has_output_compound UPa:UPC06659 ! dihydroclavaminic acid relationship: part_of UPa:UER00246 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 5/8 relationship: part_of UPa:UER00246 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 5/8 [Term] id: UPa:UCR05469 name: 2-oxoglutarate + O(2) + dihydroclavaminic acid = CO(2) + H(2)O + clavaminate + succinate namespace: reaction xref: KEGG:R05469 "KEGG reaction" xref: METACYC:RXN-6267 "MetaCyc REACTION" {source="MetaCyc"} is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06659 {cardinality="1"} ! dihydroclavaminic acid relationship: has_input_compound UPa:UPC06659 ! dihydroclavaminic acid relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC06660 ! clavaminate relationship: has_output_compound UPa:UPC06660 {cardinality="1"} ! clavaminate relationship: part_of UPa:UER00247 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 6/8 relationship: part_of UPa:UER00247 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 6/8 [Term] id: UPa:UCR05470 name: clavaminate = clavulanate-9-aldehyde namespace: reaction xref: KEGG:R05470 "KEGG reaction" xref: METACYC:RXN-8892 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42431 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06660 ! clavaminate relationship: has_input_compound UPa:UPC06660 {cardinality="1"} ! clavaminate relationship: has_output_compound UPa:UPC06661 ! clavulanate-9-aldehyde relationship: has_output_compound UPa:UPC06661 {cardinality="1"} ! clavulanate-9-aldehyde relationship: part_of UPa:UER00248 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 7/8 relationship: part_of UPa:UER00248 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 7/8 [Term] id: UPa:UCR05471 name: H(+) + NADPH + clavulanate-9-aldehyde = NADP(+) + clavulanate namespace: reaction xref: KEGG:R05471 "KEGG reaction" xref: METACYC:RXN-8893 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:42071 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC06661 {cardinality="1"} ! clavulanate-9-aldehyde relationship: has_input_compound UPa:UPC06661 ! clavulanate-9-aldehyde relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC06662 ! clavulanate relationship: has_output_compound UPa:UPC06662 {cardinality="1"} ! clavulanate relationship: part_of UPa:UER00249 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 8/8 relationship: part_of UPa:UER00249 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 8/8 [Term] id: UPa:UCR05552 name: NH(3) + chorismate = 4-amino-4-deoxychorismate + H(2)O namespace: reaction xref: KEGG:R05552 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00251 ! chorismate relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC11355 ! 4-amino-4-deoxychorismate relationship: has_output_compound UPa:UPC11355 {cardinality="1"} ! 4-amino-4-deoxychorismate relationship: part_of UPa:UER00149 {cardinality="1", direction="LR", order="1"} ! 4-aminobenzoate from chorismate: step 1/2 relationship: part_of UPa:UER00149 ! 4-aminobenzoate from chorismate: step 1/2 [Term] id: UPa:UCR05553 name: 4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate namespace: reaction xref: KEGG:R05553 "KEGG reaction" xref: METACYC:ADCLY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16204 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC11355 ! 4-amino-4-deoxychorismate relationship: has_input_compound UPa:UPC11355 {cardinality="1"} ! 4-amino-4-deoxychorismate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00568 ! 4-aminobenzoate relationship: has_output_compound UPa:UPC00568 {cardinality="1"} ! 4-aminobenzoate relationship: part_of UPa:UER00150 {cardinality="1", direction="LR", order="1"} ! 4-aminobenzoate from chorismate: step 2/2 relationship: part_of UPa:UER00150 ! 4-aminobenzoate from chorismate: step 2/2 [Term] id: UPa:UCR05554 name: 2-ureidoglycine + H(2)O = (S)-ureidoglycolate + NH(3) namespace: reaction xref: KEGG:R05554 "KEGG reaction" xref: METACYC:URUR-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25244 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02091 ! 2-ureidoglycine relationship: has_input_compound UPa:UPC02091 {cardinality="1"} ! 2-ureidoglycine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: part_of UPa:UER00655 {cardinality="1", direction="LR", order="2"} ! (S)-ureidoglycolate from allantoate (amidohydrolase route): step 1/1 relationship: part_of UPa:UER00655 ! (S)-ureidoglycolate from allantoate (amidohydrolase route): step 1/1 [Term] id: UPa:UCR05558 name: H(2)O + atrazine = HCl + hydroxyatrazine namespace: reaction xref: KEGG:R05558 "KEGG reaction" xref: METACYC:3.8.1.8-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11315 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06551 ! atrazine relationship: has_input_compound UPa:UPC06551 {cardinality="1"} ! atrazine relationship: has_output_compound UPa:UPC01327 {cardinality="1"} ! HCl relationship: has_output_compound UPa:UPC01327 ! HCl relationship: has_output_compound UPa:UPC06552 ! hydroxyatrazine relationship: has_output_compound UPa:UPC06552 {cardinality="1"} ! hydroxyatrazine relationship: part_of UPa:UER00499 {cardinality="1", direction="LR", order="1"} ! cyanurate from atrazine: step 1/3 relationship: part_of UPa:UER00499 ! cyanurate from atrazine: step 1/3 [Term] id: UPa:UCR05559 name: H(2)O + hydroxyatrazine = N-isopropylammelide + ethylamine namespace: reaction xref: KEGG:R05559 "KEGG reaction" xref: METACYC:R122-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23095 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06552 ! hydroxyatrazine relationship: has_input_compound UPa:UPC06552 {cardinality="1"} ! hydroxyatrazine relationship: has_output_compound UPa:UPC00797 ! ethylamine relationship: has_output_compound UPa:UPC00797 {cardinality="1"} ! ethylamine relationship: has_output_compound UPa:UPC06553 ! N-isopropylammelide relationship: has_output_compound UPa:UPC06553 {cardinality="1"} ! N-isopropylammelide relationship: part_of UPa:UER00500 {cardinality="1", direction="LR", order="1"} ! cyanurate from atrazine: step 2/3 relationship: part_of UPa:UER00500 ! cyanurate from atrazine: step 2/3 [Term] id: UPa:UCR05560 name: H(2)O + N-isopropylammelide = cyanurate + isopropylamine namespace: reaction xref: KEGG:R05560 "KEGG reaction" xref: METACYC:R123-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23611 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06553 ! N-isopropylammelide relationship: has_input_compound UPa:UPC06553 {cardinality="1"} ! N-isopropylammelide relationship: has_output_compound UPa:UPC06554 ! cyanurate relationship: has_output_compound UPa:UPC06554 {cardinality="1"} ! cyanurate relationship: has_output_compound UPa:UPC06748 ! isopropylamine relationship: has_output_compound UPa:UPC06748 {cardinality="1"} ! isopropylamine relationship: part_of UPa:UER00501 ! cyanurate from atrazine: step 3/3 relationship: part_of UPa:UER00501 {cardinality="1", direction="LR", order="1"} ! cyanurate from atrazine: step 3/3 [Term] id: UPa:UCR05605 name: 2-dehydro-3-deoxy-6-phospho-D-gluconic acid = D-glyceraldehyde 3-phosphate + pyruvate namespace: reaction xref: KEGG:R05605 "KEGG reaction" xref: METACYC:KDPGALDOL-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17092 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04442 ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid relationship: has_input_compound UPa:UPC04442 {cardinality="1"} ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UER00829 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 2/2 relationship: part_of UPa:UER00829 ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 2/2 [Term] id: UPa:UCR05608 name: galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O namespace: reaction xref: KEGG:R05608 "KEGG reaction" xref: METACYC:GALACTARDEHYDRA-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16008 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00879 ! galactarate relationship: has_input_compound UPa:UPC00879 {cardinality="1"} ! galactarate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00679 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucarate relationship: has_output_compound UPa:UPC00679 ! 5-dehydro-4-deoxy-D-glucarate relationship: part_of UPa:UER00629 ! D-glycerate from galactarate: step 1/3 relationship: part_of UPa:UER00629 {cardinality="1", direction="LR", order="1"} ! D-glycerate from galactarate: step 1/3 [Term] id: UPa:UCR05621 name: H(+) + NADH + O(2) + benzoate = (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid + NAD(+) namespace: reaction xref: KEGG:R05621 "KEGG reaction" xref: METACYC:BENZOATE-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12636 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: has_input_compound UPa:UPC00180 ! benzoate relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC06321 {cardinality="1"} ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid relationship: has_output_compound UPa:UPC06321 ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid relationship: part_of UPa:UER00254 ! catechol from benzoate: step 1/2 relationship: part_of UPa:UER00254 {cardinality="1", direction="LR", order="1"} ! catechol from benzoate: step 1/2 [Term] id: UPa:UCR05633 name: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate namespace: reaction xref: KEGG:R05633 "KEGG reaction" xref: METACYC:2.7.7.60-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13432 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC11434 ! 2-C-methyl-D-erythritol 4-phosphate relationship: has_input_compound UPa:UPC11434 {cardinality="1"} ! 2-C-methyl-D-erythritol 4-phosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC11435 ! 4-CDP-2-C-methyl-D-erythritol relationship: has_output_compound UPa:UPC11435 {cardinality="1"} ! 4-CDP-2-C-methyl-D-erythritol relationship: part_of UPa:UER00093 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6 relationship: part_of UPa:UER00093 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6 [Term] id: UPa:UCR05634 name: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP namespace: reaction xref: KEGG:R05634 "KEGG reaction" xref: METACYC:2.7.1.148-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18440 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC11435 ! 4-CDP-2-C-methyl-D-erythritol relationship: has_input_compound UPa:UPC11435 {cardinality="1"} ! 4-CDP-2-C-methyl-D-erythritol relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC11436 ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate relationship: has_output_compound UPa:UPC11436 {cardinality="1"} ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate relationship: part_of UPa:UER00094 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6 relationship: part_of UPa:UER00094 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6 [Term] id: UPa:UCR05636 name: D-glyceraldehyde 3-phosphate + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2) namespace: reaction xref: KEGG:R05636 "KEGG reaction" xref: METACYC:DXS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12608 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:UER00091 {cardinality="1", direction="LR", order="1"} ! 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1 relationship: part_of UPa:UER00091 ! 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1 [Term] id: UPa:UCR05637 name: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP namespace: reaction xref: KEGG:R05637 "KEGG reaction" xref: METACYC:RXN0-302 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23867 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC11436 {cardinality="1"} ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate relationship: has_input_compound UPa:UPC11436 ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC11453 ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate relationship: has_output_compound UPa:UPC11453 {cardinality="1"} ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate relationship: part_of UPa:UER00095 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6 relationship: part_of UPa:UER00095 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6 [Term] id: UPa:UCR05639 name: 14-demethyllanosterol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH namespace: reaction xref: KEGG:R05639 "KEGG reaction" xref: METACYC:RXN66-306 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18564 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC05108 {cardinality="1"} ! 14-demethyllanosterol relationship: has_input_compound UPa:UPC05108 ! 14-demethyllanosterol relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC11455 ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol relationship: has_output_compound UPa:UPC11455 {cardinality="1"} ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol relationship: part_of UPa:UER00755 {cardinality="1", direction="RL", order="1"} ! zymosterol from lanosterol: step 2/6 relationship: part_of UPa:UER00755 ! zymosterol from lanosterol: step 2/6 [Term] id: UPa:UCR05640 name: 3 H(+) + 3 NADPH + 3 O(2) + lanosterol = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + 4 H(2)O + 3 NADP(+) + formate namespace: reaction xref: KEGG:R05640 "KEGG reaction" xref: METACYC:RXN3O-130 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25289 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01724 {cardinality="1"} ! lanosterol relationship: has_input_compound UPa:UPC01724 ! lanosterol relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC11455 ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol relationship: has_output_compound UPa:UPC11455 {cardinality="1"} ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol relationship: part_of UPa:UER00754 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 1/6 relationship: part_of UPa:UER00754 ! zymosterol from lanosterol: step 1/6 [Term] id: UPa:UCR05641 name: NADP(+) + ergosterol = H(+) + NADPH + ergosta-5,7,22,24(28)-tetraen-3beta-ol namespace: reaction xref: KEGG:R05641 "KEGG reaction" xref: METACYC:1.3.1.71-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18504 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC01694 {cardinality="1"} ! ergosterol relationship: has_input_compound UPa:UPC01694 ! ergosterol relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC05440 ! ergosta-5,7,22,24(28)-tetraen-3beta-ol relationship: has_output_compound UPa:UPC05440 {cardinality="1"} ! ergosta-5,7,22,24(28)-tetraen-3beta-ol relationship: part_of UPa:UER00764 ! ergosterol from zymosterol: step 5/5 relationship: part_of UPa:UER00764 {cardinality="1", direction="RL", order="1"} ! ergosterol from zymosterol: step 5/5 [Term] id: UPa:UCR05644 name: ATP + D-glycero-beta-D-manno-heptose 1-phosphate = ADP-D-glycero-beta-D-manno-heptose + diphosphate namespace: reaction xref: KEGG:R05644 "KEGG reaction" xref: METACYC:RXN0-4342 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:27468 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC07838 ! D-glycero-beta-D-manno-heptose 1-phosphate relationship: has_input_compound UPa:UPC07838 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 1-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC06397 {cardinality="1"} ! ADP-D-glycero-beta-D-manno-heptose relationship: has_output_compound UPa:UPC06397 ! ADP-D-glycero-beta-D-manno-heptose relationship: part_of UPa:UER00439 {cardinality="1", direction="LR", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4 relationship: part_of UPa:UER00439 ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4 [Term] id: UPa:UCR05646 name: ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-diphosphate namespace: reaction xref: KEGG:R05646 "KEGG reaction" xref: RHEA:27476 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC07836 ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_input_compound UPa:UPC07836 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC11472 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 1,7-diphosphate relationship: has_output_compound UPa:UPC11472 ! D-glycero-beta-D-manno-heptose 1,7-diphosphate relationship: part_of UPa:UER00437 {cardinality="1", direction="LR", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4 relationship: part_of UPa:UER00437 ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4 [Term] id: UPa:UCR05647 name: D-glycero-beta-D-manno-heptose 1,7-diphosphate + H(2)O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate namespace: reaction xref: KEGG:R05647 "KEGG reaction" xref: METACYC:RXN0-4361 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28521 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC11472 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 1,7-diphosphate relationship: has_input_compound UPa:UPC11472 ! D-glycero-beta-D-manno-heptose 1,7-diphosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC07838 ! D-glycero-beta-D-manno-heptose 1-phosphate relationship: has_output_compound UPa:UPC07838 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 1-phosphate relationship: part_of UPa:UER00438 {cardinality="1", direction="LR", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 2/4 relationship: part_of UPa:UER00438 ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 2/4 [Term] id: UPa:UCR05651 name: phosphate + sulfoacetaldehyde = acetyl phosphate + sulfite namespace: reaction xref: KEGG:R05651 "KEGG reaction" xref: METACYC:RXN-2364 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24207 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00593 ! sulfoacetaldehyde relationship: has_input_compound UPa:UPC00593 {cardinality="1"} ! sulfoacetaldehyde relationship: has_output_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_output_compound UPa:UPC00227 ! acetyl phosphate relationship: has_output_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate relationship: part_of UPa:UER00544 ! acetyl phosphate and sulfite from taurine: step 2/2 relationship: part_of UPa:UER00544 {cardinality="1", direction="LR", order="1"} ! acetyl phosphate and sulfite from taurine: step 2/2 [Term] id: UPa:UCR05652 name: pyruvate + taurine = L-alanine + sulfoacetaldehyde namespace: reaction xref: KEGG:R05652 "KEGG reaction" xref: METACYC:TAURINE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10423 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00245 {cardinality="1"} ! taurine relationship: has_input_compound UPa:UPC00245 ! taurine relationship: has_output_compound UPa:UPC00041 ! L-alanine relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00593 {cardinality="1"} ! sulfoacetaldehyde relationship: has_output_compound UPa:UPC00593 ! sulfoacetaldehyde relationship: part_of UPa:UER00543 ! acetyl phosphate and sulfite from taurine: step 1/2 relationship: part_of UPa:UER00543 {cardinality="1", direction="LR", order="1"} ! acetyl phosphate and sulfite from taurine: step 1/2 [Term] id: UPa:UCR05661 name: 2-deoxy-5-keto-D-gluconic acid + ATP = 6-phospho-5-dehydro-2-deoxy-D-gluconic acid + ADP namespace: reaction xref: KEGG:R05661 "KEGG reaction" xref: METACYC:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13500 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC06892 {cardinality="1"} ! 2-deoxy-5-keto-D-gluconic acid relationship: has_input_compound UPa:UPC06892 ! 2-deoxy-5-keto-D-gluconic acid relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC06893 ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid relationship: has_output_compound UPa:UPC06893 {cardinality="1"} ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid relationship: part_of UPa:UER00146 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 5/7 relationship: part_of UPa:UER00146 ! acetyl-CoA from myo-inositol: step 5/7 [Term] id: UPa:UCR05681 name: 4-(phosphonooxy)-L-threonine + NAD(+) = 2-amino-3-oxo-4-phosphonooxybutyrate + H(+) + NADH namespace: reaction xref: KEGG:R05681 "KEGG reaction" xref: METACYC:1.1.1.262-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14456 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC06055 {cardinality="1"} ! 4-(phosphonooxy)-L-threonine relationship: has_input_compound UPa:UPC06055 ! 4-(phosphonooxy)-L-threonine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC07335 {cardinality="1"} ! 2-amino-3-oxo-4-phosphonooxybutyrate relationship: has_output_compound UPa:UPC07335 ! 2-amino-3-oxo-4-phosphonooxybutyrate relationship: part_of UPa:UER00312 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5 relationship: part_of UPa:UER00312 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5 [Term] id: UPa:UCR05688 name: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH namespace: reaction xref: KEGG:R05688 "KEGG reaction" xref: METACYC:DXPREDISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13720 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC11434 ! 2-C-methyl-D-erythritol 4-phosphate relationship: has_input_compound UPa:UPC11434 {cardinality="1"} ! 2-C-methyl-D-erythritol 4-phosphate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:UER00092 {cardinality="1", direction="RL", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6 relationship: part_of UPa:UER00092 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6 [Term] id: UPa:UCR05692 name: GDP-L-fucose + NADP(+) = GDP-4-dehydro-6-deoxy-D-mannose + H(+) + NADPH namespace: reaction xref: KEGG:R05692 "KEGG reaction" xref: METACYC:1.1.1.271-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18888 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00325 ! GDP-L-fucose relationship: has_input_compound UPa:UPC00325 {cardinality="1"} ! GDP-L-fucose relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01222 ! GDP-4-dehydro-6-deoxy-D-mannose relationship: has_output_compound UPa:UPC01222 {cardinality="1"} ! GDP-4-dehydro-6-deoxy-D-mannose relationship: part_of UPa:UER00191 ! GDP-L-fucose from GDP-alpha-D-mannose: step 2/2 relationship: part_of UPa:UER00191 {cardinality="1", direction="RL", order="1"} ! GDP-L-fucose from GDP-alpha-D-mannose: step 2/2 [Term] id: UPa:UCR05728 name: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H(+) + NADPH + O(2) = (S)-4-hydroxymandelonitrile + 2 H(2)O + NADP(+) namespace: reaction xref: KEGG:R05728 "KEGG reaction" xref: METACYC:1.14.13.68-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18404 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC04353 {cardinality="1"} ! (Z)-(4-hydroxyphenyl)acetaldehyde oxime relationship: has_input_compound UPa:UPC04353 ! (Z)-(4-hydroxyphenyl)acetaldehyde oxime relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC03742 ! (S)-4-hydroxymandelonitrile relationship: has_output_compound UPa:UPC03742 {cardinality="1"} ! (S)-4-hydroxymandelonitrile relationship: part_of UPa:UER00745 ! dhurrin from L-tyrosine: step 2/3 relationship: part_of UPa:UER00745 {cardinality="1", direction="LR", order="1"} ! dhurrin from L-tyrosine: step 2/3 [Term] id: UPa:UCR05732 name: (S)-N-methylcoclaurine + H(+) + NADPH + O(2) = (S)-3'-hydroxy-N-methylcoclaurine + H(2)O + NADP(+) namespace: reaction xref: KEGG:R05732 "KEGG reaction" xref: METACYC:1.14.13.71-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16652 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC05176 ! (S)-N-methylcoclaurine relationship: has_input_compound UPa:UPC05176 {cardinality="1"} ! (S)-N-methylcoclaurine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC05202 {cardinality="1"} ! (S)-3'-hydroxy-N-methylcoclaurine relationship: has_output_compound UPa:UPC05202 ! (S)-3'-hydroxy-N-methylcoclaurine relationship: part_of UPa:UER00443 ! (S)-reticuline from (S)-norcoclaurine: step 3/4 relationship: part_of UPa:UER00443 {cardinality="1", direction="LR", order="1"} ! (S)-reticuline from (S)-norcoclaurine: step 3/4 [Term] id: UPa:UCR05765 name: geranyl diphosphate = (-)-alpha-pinene + diphosphate namespace: reaction xref: KEGG:R05765 "KEGG reaction" xref: METACYC:RXN-5106 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25491 "Rhea reaction" xref: RHEA:25665 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC06308 {cardinality="1"} ! (-)-alpha-pinene relationship: has_output_compound UPa:UPC06308 ! (-)-alpha-pinene relationship: part_of UPa:UER00927 {cardinality="1", direction="LR", order="1"} ! (-)-alpha-pinene from geranyl diphosphate: step 1/1 relationship: part_of UPa:UER00927 ! (-)-alpha-pinene from geranyl diphosphate: step 1/1 [Term] id: UPa:UCR05766 name: geranyl diphosphate = (-)-beta-pinene + diphosphate namespace: reaction xref: KEGG:R05766 "KEGG reaction" xref: METACYC:RXN-5107 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25499 "Rhea reaction" xref: RHEA:25669 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC06307 {cardinality="1"} ! (-)-beta-pinene relationship: has_output_compound UPa:UPC06307 ! (-)-beta-pinene relationship: part_of UPa:UER00928 {cardinality="1", direction="LR", order="1"} ! (-)-beta-pinene from geranyl diphosphate: step 1/1 relationship: part_of UPa:UER00928 ! (-)-beta-pinene from geranyl diphosphate: step 1/1 [Term] id: UPa:UCR05768 name: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglyceric acid + GDP namespace: reaction xref: KEGG:R05768 "KEGG reaction" xref: METACYC:2.4.1.217-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13540 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: has_input_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_output_compound UPa:UPC00035 ! GDP relationship: has_output_compound UPa:UPC11516 ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid relationship: has_output_compound UPa:UPC11516 {cardinality="1"} ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid relationship: part_of UPa:UER00192 {cardinality="1", direction="LR", order="1"} ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 1/2 relationship: part_of UPa:UER00192 ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 1/2 [Term] id: UPa:UCR05774 name: 3-sulfopyruvate = CO(2) + sulfoacetaldehyde namespace: reaction xref: KEGG:R05774 "KEGG reaction" xref: METACYC:R231-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20951 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC05528 {cardinality="1"} ! 3-sulfopyruvate relationship: has_input_compound UPa:UPC05528 ! 3-sulfopyruvate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00593 {cardinality="1"} ! sulfoacetaldehyde relationship: has_output_compound UPa:UPC00593 ! sulfoacetaldehyde relationship: part_of UPa:UER00472 {cardinality="1", direction="LR", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 4/4 relationship: part_of UPa:UER00472 ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 4/4 [Term] id: UPa:UCR05784 name: (4R)-limonene 1,2-epoxide + H(2)O = (1S,2S,4R)-limonene-1,2-diol namespace: reaction xref: KEGG:R05784 "KEGG reaction" xref: METACYC:RXN-9412 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10703 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC07271 {cardinality="1"} ! (4R)-limonene 1,2-epoxide relationship: has_input_compound UPa:UPC07271 ! (4R)-limonene 1,2-epoxide relationship: has_output_compound UPa:UPC07276 ! (1S,2S,4R)-limonene-1,2-diol relationship: has_output_compound UPa:UPC07276 {cardinality="1"} ! (1S,2S,4R)-limonene-1,2-diol relationship: part_of UPa:UER00865 {cardinality="1", direction="LR", order="1"} ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 2/3 relationship: part_of UPa:UER00865 ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 2/3 [Term] id: UPa:UCR05789 name: (2R)-O-phospho-3-sulfolactic acid + H(2)O = (R)-3-sulfolactate + phosphate namespace: reaction xref: KEGG:R05789 "KEGG reaction" xref: METACYC:R229-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23419 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC11536 {cardinality="1"} ! (2R)-O-phospho-3-sulfolactic acid relationship: has_input_compound UPa:UPC11536 ! (2R)-O-phospho-3-sulfolactic acid relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC11537 ! (R)-3-sulfolactate relationship: has_output_compound UPa:UPC11537 {cardinality="1"} ! (R)-3-sulfolactate relationship: part_of UPa:UER00470 {cardinality="1", direction="LR", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 2/4 relationship: part_of UPa:UER00470 ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 2/4 [Term] id: UPa:UCR05790 name: 2-(alpha-D-mannosyl)-3-phosphoglyceric acid + H(2)O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate namespace: reaction xref: KEGG:R05790 "KEGG reaction" xref: METACYC:3.1.3.70-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19312 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC11516 {cardinality="1"} ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid relationship: has_input_compound UPa:UPC11516 ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC11544 ! 2-(alpha-D-mannosyl)-D-glycerate relationship: has_output_compound UPa:UPC11544 {cardinality="1"} ! 2-(alpha-D-mannosyl)-D-glycerate relationship: part_of UPa:UER00193 {cardinality="1", direction="LR", order="1"} ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 2/2 relationship: part_of UPa:UER00193 ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 2/2 [Term] id: UPa:UCR05794 name: CDP-diacylglycerol + choline = CMP + phosphatidylcholine namespace: reaction xref: KEGG:R05794 "KEGG reaction" xref: METACYC:2.7.8.24-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14600 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00157 {cardinality="1"} ! phosphatidylcholine relationship: has_output_compound UPa:UPC00157 ! phosphatidylcholine relationship: part_of UPa:UER00940 ! phosphatidylcholine from choline: step 1/1 relationship: part_of UPa:UER00940 {cardinality="1", direction="LR", order="1"} ! phosphatidylcholine from choline: step 1/1 [Term] id: UPa:UCR05807 name: Co(2+) + sirohydrochlorin = 2 H(+) + cobalt-precorrin-2 namespace: reaction xref: KEGG:R05807 "KEGG reaction" xref: METACYC:4.99.1.3-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15896 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00175 ! Co(2+) relationship: has_input_compound UPa:UPC00175 {cardinality="1"} ! Co(2+) relationship: has_input_compound UPa:UPC05778 {cardinality="1"} ! sirohydrochlorin relationship: has_input_compound UPa:UPC05778 ! sirohydrochlorin relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC11538 ! cobalt-precorrin-2 relationship: has_output_compound UPa:UPC11538 {cardinality="1"} ! cobalt-precorrin-2 relationship: part_of UPa:UER00223 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 1/10 relationship: part_of UPa:UER00223 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 1/10 [Term] id: UPa:UCR05808 name: S-adenosyl-L-methionine + cobalt-precorrin-2 = S-adenosyl-L-homocysteine + cobalt-factor III namespace: reaction xref: KEGG:R05808 "KEGG reaction" xref: METACYC:2.1.1.151-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18000 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11538 ! cobalt-precorrin-2 relationship: has_input_compound UPa:UPC11538 {cardinality="1"} ! cobalt-precorrin-2 relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC17401 ! cobalt-factor III relationship: has_output_compound UPa:UPC17401 {cardinality="1"} ! cobalt-factor III relationship: part_of UPa:UER00224 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 2/10 relationship: part_of UPa:UER00224 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 2/10 [Term] id: UPa:UCR05809 name: S-adenosyl-L-methionine + cobalt-precorrin 3 = S-adenosyl-L-homocysteine + cobalt-precorrin 4 namespace: reaction xref: KEGG:R05809 "KEGG reaction" xref: METACYC:RXN-8761 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26276 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11539 ! cobalt-precorrin 3 relationship: has_input_compound UPa:UPC11539 {cardinality="1"} ! cobalt-precorrin 3 relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11540 ! cobalt-precorrin 4 relationship: has_output_compound UPa:UPC11540 {cardinality="1"} ! cobalt-precorrin 4 relationship: part_of UPa:UER00225 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 3/10 relationship: part_of UPa:UER00225 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 3/10 [Term] id: UPa:UCR05810 name: S-adenosyl-L-methionine + cobalt-precorrin 4 = S-adenosyl-L-homocysteine + cobalt-precorrin 5A namespace: reaction xref: KEGG:R05810 "KEGG reaction" xref: METACYC:RXN-8762 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26280 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11540 {cardinality="1"} ! cobalt-precorrin 4 relationship: has_input_compound UPa:UPC11540 ! cobalt-precorrin 4 relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC16242 {cardinality="1"} ! cobalt-precorrin 5A relationship: has_output_compound UPa:UPC16242 ! cobalt-precorrin 5A relationship: part_of UPa:UER00226 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 4/10 relationship: part_of UPa:UER00226 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 4/10 [Term] id: UPa:UCR05812 name: H(+) + NADH + cobalt-precorrin-6A = NAD(+) + cobalt-precorrin-6B namespace: reaction xref: KEGG:R05812 "KEGG reaction" xref: METACYC:RXN-8765 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15628 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC11542 {cardinality="1"} ! cobalt-precorrin-6A relationship: has_input_compound UPa:UPC11542 ! cobalt-precorrin-6A relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC11543 {cardinality="1"} ! cobalt-precorrin-6B relationship: has_output_compound UPa:UPC11543 ! cobalt-precorrin-6B relationship: part_of UPa:UER00228 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 7/10 relationship: part_of UPa:UER00228 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 7/10 [Term] id: UPa:UCR05813 name: 2 S-adenosyl-L-methionine + cobalt-precorrin-6B = CO(2) + 2 S-adenosyl-L-homocysteine + cobalt-precorrin 8 namespace: reaction xref: KEGG:R05813 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11543 {cardinality="1"} ! cobalt-precorrin-6B relationship: has_input_compound UPa:UPC11543 ! cobalt-precorrin-6B relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11545 {cardinality="1"} ! cobalt-precorrin 8 relationship: has_output_compound UPa:UPC11545 ! cobalt-precorrin 8 relationship: part_of UPa:UER00229 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10 relationship: part_of UPa:UER00229 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10 [Term] id: UPa:UCR05814 name: cobalt-precorrin 8 = cob(III)yrinic acid namespace: reaction xref: KEGG:R05814 "KEGG reaction" xref: METACYC:RXN-8768 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16212 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC11545 {cardinality="1"} ! cobalt-precorrin 8 relationship: has_input_compound UPa:UPC11545 ! cobalt-precorrin 8 relationship: has_output_compound UPa:UPC05773 ! cob(III)yrinic acid relationship: has_output_compound UPa:UPC05773 {cardinality="1"} ! cob(III)yrinic acid relationship: part_of UPa:UER00230 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 9/10 relationship: part_of UPa:UER00230 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 9/10 [Term] id: UPa:UCR05815 name: 2 ATP + 2 H(2)O + 2 L-glutamine + cob(III)yrinic acid = 2 ADP + 2 L-glutamate + cob(II)yrinate a,c-diamide + 2 phosphate namespace: reaction xref: KEGG:R05815 "KEGG reaction" xref: METACYC:RXN-8769 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26292 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC05773 {cardinality="1"} ! cob(III)yrinic acid relationship: has_input_compound UPa:UPC05773 ! cob(III)yrinic acid relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC06504 ! cob(II)yrinate a,c-diamide relationship: has_output_compound UPa:UPC06504 {cardinality="1"} ! cob(II)yrinate a,c-diamide relationship: part_of UPa:UER00231 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10 relationship: part_of UPa:UER00231 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10 [Term] id: UPa:UCR05820 name: D-sorbitol + protein N(pi)-phospho-L-histidine = D-sorbitol 6-phosphate + protein-L-histidine namespace: reaction xref: KEGG:R05820 "KEGG reaction" xref: RHEA:42487 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00794 {cardinality="1"} ! D-sorbitol relationship: has_input_compound UPa:UPC00794 ! D-sorbitol relationship: has_input_compound UPa:UPC04261 {cardinality="1"} ! protein N(pi)-phospho-L-histidine relationship: has_input_compound UPa:UPC04261 ! protein N(pi)-phospho-L-histidine relationship: has_output_compound UPa:UPC00615 {cardinality="1"} ! protein-L-histidine relationship: has_output_compound UPa:UPC00615 ! protein-L-histidine relationship: has_output_compound UPa:UPC01096 ! D-sorbitol 6-phosphate relationship: has_output_compound UPa:UPC01096 {cardinality="1"} ! D-sorbitol 6-phosphate relationship: part_of UPa:UER00782 ! D-sorbitol 6-phosphate from D-sorbitol: step 1/1 relationship: part_of UPa:UER00782 {cardinality="1", direction="LR", order="1"} ! D-sorbitol 6-phosphate from D-sorbitol: step 1/1 [Term] id: UPa:UCR05838 name: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H(2)O + phosphate + pyridoxine 5'-phosphate namespace: reaction xref: KEGG:R05838 "KEGG reaction" xref: METACYC:PDXJ-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15268 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC11638 {cardinality="1"} ! 3-amino-2-oxopropyl phosphate relationship: has_input_compound UPa:UPC11638 ! 3-amino-2-oxopropyl phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00627 ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate relationship: part_of UPa:UER00313 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5 relationship: part_of UPa:UER00313 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5 [Term] id: UPa:UCR05850 name: L-ribulose 5-phosphate = D-xylulose 5-phosphate namespace: reaction xref: KEGG:R05850 "KEGG reaction" xref: METACYC:RIBULPEPIM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22371 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01101 {cardinality="1"} ! L-ribulose 5-phosphate relationship: has_input_compound UPa:UPC01101 ! L-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: part_of UPa:UER00380 ! D-xylulose 5-phosphate from L-ascorbate: step 4/4 relationship: part_of UPa:UER00380 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-ascorbate: step 4/4 relationship: part_of UPa:UER00567 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3 relationship: part_of UPa:UER00567 ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3 [Term] id: UPa:UCR05855 name: H(+) + NADPH + O(2) + tabersonine = 16-hydroxytabersonine + H(2)O + NADP(+) namespace: reaction xref: KEGG:R05855 "KEGG reaction" xref: METACYC:1.14.13.73-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14136 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC09244 ! tabersonine relationship: has_input_compound UPa:UPC09244 {cardinality="1"} ! tabersonine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC11643 ! 16-hydroxytabersonine relationship: has_output_compound UPa:UPC11643 {cardinality="1"} ! 16-hydroxytabersonine relationship: part_of UPa:UER00521 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 1/6 relationship: part_of UPa:UER00521 ! vindoline from tabersonine: step 1/6 [Term] id: UPa:UCR05856 name: 16-methoxytabersonine + H(2)O = 3-hydroxy-16-methoxy-2,3-dihydrotabersonine namespace: reaction xref: KEGG:R05856 "KEGG reaction" xref: METACYC:RXN-8200 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42375 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC11675 ! 16-methoxytabersonine relationship: has_input_compound UPa:UPC11675 {cardinality="1"} ! 16-methoxytabersonine relationship: has_output_compound UPa:UPC04578 ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine relationship: has_output_compound UPa:UPC04578 {cardinality="1"} ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine relationship: part_of UPa:UER00523 ! vindoline from tabersonine: step 3/6 relationship: part_of UPa:UER00523 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 3/6 [Term] id: UPa:UCR05857 name: 2-oxoglutarate + O(2) + desacetoxyvindoline = CO(2) + deacetylvindoline + succinate namespace: reaction xref: KEGG:R05857 "KEGG reaction" xref: METACYC:1.14.11.20-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18976 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC02673 ! desacetoxyvindoline relationship: has_input_compound UPa:UPC02673 {cardinality="1"} ! desacetoxyvindoline relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC01091 {cardinality="1"} ! deacetylvindoline relationship: has_output_compound UPa:UPC01091 ! deacetylvindoline relationship: part_of UPa:UER00525 ! vindoline from tabersonine: step 5/6 relationship: part_of UPa:UER00525 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 5/6 [Term] id: UPa:UCR05884 name: (2E)-4-hydroxy-3-methylbutenyl diphosphate + H(+) + NADPH = H(2)O + NADP(+) + isopentenyl diphosphate namespace: reaction xref: KEGG:R05884 "KEGG reaction" xref: METACYC:ISPH2-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24491 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC11811 {cardinality="1"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_input_compound UPa:UPC11811 ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_output_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: part_of UPa:UER00097 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6 relationship: part_of UPa:UER00097 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6 [Term] id: UPa:UCR05885 name: 16-hydroxytabersonine + S-adenosyl-L-methionine = 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R05885 "KEGG reaction" xref: METACYC:2.1.1.94-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20995 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11643 ! 16-hydroxytabersonine relationship: has_input_compound UPa:UPC11643 {cardinality="1"} ! 16-hydroxytabersonine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC11675 {cardinality="1"} ! 16-methoxytabersonine relationship: has_output_compound UPa:UPC11675 ! 16-methoxytabersonine relationship: part_of UPa:UER00522 ! vindoline from tabersonine: step 2/6 relationship: part_of UPa:UER00522 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 2/6 [Term] id: UPa:UCR06117 name: (4S,6R)-trans-carveol + NAD(+) = (S)-carvone + H(+) + NADH namespace: reaction xref: KEGG:R06117 "KEGG reaction" xref: METACYC:RXN-9397 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14828 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC11409 ! (4S,6R)-trans-carveol relationship: has_input_compound UPa:UPC11409 {cardinality="1"} ! (4S,6R)-trans-carveol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC11383 ! (S)-carvone relationship: has_output_compound UPa:UPC11383 {cardinality="1"} ! (S)-carvone relationship: part_of UPa:UER00868 ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 2/3 relationship: part_of UPa:UER00868 {cardinality="1", direction="LR", order="1"} ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 2/3 [Term] id: UPa:UCR06119 name: (4R)-limonene + H(+) + NADPH + O(2) = (4S,6R)-trans-carveol + H(2)O + NADP(+) namespace: reaction xref: KEGG:R06119 "KEGG reaction" xref: METACYC:RXN-10746 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18960 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC06099 ! (4R)-limonene relationship: has_input_compound UPa:UPC06099 {cardinality="1"} ! (4R)-limonene relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC11409 {cardinality="1"} ! (4S,6R)-trans-carveol relationship: has_output_compound UPa:UPC11409 ! (4S,6R)-trans-carveol relationship: part_of UPa:UER00867 ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 1/3 relationship: part_of UPa:UER00867 {cardinality="1", direction="LR", order="1"} ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 1/3 [Term] id: UPa:UCR06120 name: geranyl diphosphate = (4R)-limonene + diphosphate namespace: reaction xref: KEGG:R06120 "KEGG reaction" xref: METACYC:4.2.3.20-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10943 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC06099 {cardinality="1"} ! (4R)-limonene relationship: has_output_compound UPa:UPC06099 ! (4R)-limonene relationship: part_of UPa:UER00926 ! (4R)-limonene from geranyl diphosphate: step 1/1 relationship: part_of UPa:UER00926 {cardinality="1", direction="LR", order="1"} ! (4R)-limonene from geranyl diphosphate: step 1/1 [Term] id: UPa:UCR06171 name: L-allo-threonine = acetaldehyde + glycine namespace: reaction xref: KEGG:R06171 "KEGG reaction" xref: METACYC:LTAA-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:26212 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC05519 ! L-allo-threonine relationship: has_input_compound UPa:UPC05519 {cardinality="1"} ! L-allo-threonine relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: part_of UPa:UER00427 ! glycine from L-allo-threonine: step 1/1 relationship: part_of UPa:UER00427 {cardinality="1", direction="LR", order="1"} ! glycine from L-allo-threonine: step 1/1 [Term] id: UPa:UCR06180 name: L-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH namespace: reaction xref: KEGG:R06180 "KEGG reaction" xref: METACYC:TARTRATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15212 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00898 ! L-tartrate relationship: has_input_compound UPa:UPC00898 {cardinality="1"} ! L-tartrate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate relationship: part_of UPa:UER00800 ! 2-hydroxy-3-oxosuccinate from L-tartrate: step 1/1 relationship: part_of UPa:UER00800 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-3-oxosuccinate from L-tartrate: step 1/1 [Term] id: UPa:UCR06223 name: H(+) + NADPH + 2 farnesyl diphosphate = NADP(+) + 2 diphosphate + squalene namespace: reaction xref: KEGG:R06223 "KEGG reaction" xref: RHEA:32298 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00751 {cardinality="1"} ! squalene relationship: has_output_compound UPa:UPC00751 ! squalene relationship: part_of UPa:UER00751 ! lanosterol from farnesyl diphosphate: step 1/3 relationship: part_of UPa:UER00751 {cardinality="1", direction="LR", order="1"} ! lanosterol from farnesyl diphosphate: step 1/3 [Term] id: UPa:UCR06305 name: geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene namespace: reaction xref: KEGG:R06305 "KEGG reaction" xref: METACYC:4.2.3.17-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20915 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate relationship: has_input_compound UPa:UPC00353 ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC11894 ! taxa-4,11-diene relationship: has_output_compound UPa:UPC11894 {cardinality="1"} ! taxa-4,11-diene relationship: part_of UPa:UER00806 {cardinality="1", direction="LR", order="1"} ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate: step 1/2 relationship: part_of UPa:UER00806 ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate: step 1/2 [Term] id: UPa:UCR06306 name: O(2) + reduced acceptor + taxa-4,11-diene = H(2)O + acceptor + taxa-4(20),11-dien-5alpha-ol namespace: reaction xref: KEGG:R06306 "KEGG reaction" xref: METACYC:1.14.99.37-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14052 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00030 ! reduced acceptor relationship: has_input_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_input_compound UPa:UPC11894 ! taxa-4,11-diene relationship: has_input_compound UPa:UPC11894 {cardinality="1"} ! taxa-4,11-diene relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_output_compound UPa:UPC00028 ! acceptor relationship: has_output_compound UPa:UPC11895 ! taxa-4(20),11-dien-5alpha-ol relationship: has_output_compound UPa:UPC11895 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-ol relationship: part_of UPa:UER00807 {cardinality="1", direction="LR", order="1"} ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate: step 2/2 relationship: part_of UPa:UER00807 ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate: step 2/2 [Term] id: UPa:UCR06307 name: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate namespace: reaction xref: KEGG:R06307 "KEGG reaction" xref: METACYC:2.3.1.162-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22031 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC11895 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-ol relationship: has_input_compound UPa:UPC11895 ! taxa-4(20),11-dien-5alpha-ol relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC11896 ! taxa-4(20),11-dien-5alpha-yl acetate relationship: has_output_compound UPa:UPC11896 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-yl acetate relationship: part_of UPa:UER00808 {cardinality="1", direction="LR", order="1"} ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 1/3 relationship: part_of UPa:UER00808 ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 1/3 [Term] id: UPa:UCR06309 name: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O + NADP(+) namespace: reaction xref: KEGG:R06309 "KEGG reaction" xref: METACYC:1.14.13.76-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15244 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC11896 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-yl acetate relationship: has_input_compound UPa:UPC11896 ! taxa-4(20),11-dien-5alpha-yl acetate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC11898 ! 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate relationship: has_output_compound UPa:UPC11898 {cardinality="1"} ! 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate relationship: part_of UPa:UER00809 ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 2/3 relationship: part_of UPa:UER00809 {cardinality="1", direction="LR", order="1"} ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 2/3 [Term] id: UPa:UCR06310 name: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA namespace: reaction xref: KEGG:R06310 "KEGG reaction" xref: METACYC:2.3.1.166-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18744 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00512 ! benzoyl-CoA relationship: has_input_compound UPa:UPC00512 {cardinality="1"} ! benzoyl-CoA relationship: has_input_compound UPa:UPC11899 ! 10-deacetyl-2-debenzoylbaccatin III relationship: has_input_compound UPa:UPC11899 {cardinality="1"} ! 10-deacetyl-2-debenzoylbaccatin III relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC11700 ! 10-deacetylbaccatin III relationship: has_output_compound UPa:UPC11700 {cardinality="1"} ! 10-deacetylbaccatin III relationship: part_of UPa:UER00810 ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III: step 1/2 relationship: part_of UPa:UER00810 {cardinality="1", direction="LR", order="1"} ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III: step 1/2 [Term] id: UPa:UCR06311 name: 10-deacetylbaccatin III + acetyl-CoA = CoA + baccatin III namespace: reaction xref: KEGG:R06311 "KEGG reaction" xref: METACYC:2.3.1.167-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20140 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC11700 {cardinality="1"} ! 10-deacetylbaccatin III relationship: has_input_compound UPa:UPC11700 ! 10-deacetylbaccatin III relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC11900 ! baccatin III relationship: has_output_compound UPa:UPC11900 {cardinality="1"} ! baccatin III relationship: part_of UPa:UER00811 ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III: step 2/2 relationship: part_of UPa:UER00811 {cardinality="1", direction="LR", order="1"} ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III: step 2/2 [Term] id: UPa:UCR06372 name: (S)-carvone + reduced acceptor = (1R,4S)-isodihydrocarvone + acceptor namespace: reaction xref: KEGG:R06372 "KEGG reaction" xref: METACYC:RXN-9419 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:32430 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00030 ! reduced acceptor relationship: has_input_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_input_compound UPa:UPC11383 ! (S)-carvone relationship: has_input_compound UPa:UPC11383 {cardinality="1"} ! (S)-carvone relationship: has_output_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_output_compound UPa:UPC00028 ! acceptor relationship: has_output_compound UPa:UPC11412 ! (1R,4S)-isodihydrocarvone relationship: has_output_compound UPa:UPC11412 {cardinality="1"} ! (1R,4S)-isodihydrocarvone relationship: part_of UPa:UER00869 {cardinality="1", direction="LR", order="1"} ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 3/3 relationship: part_of UPa:UER00869 ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 3/3 [Term] id: UPa:UCR06398 name: (4R)-limonene + H(+) + NADH + O(2) = (4R)-limonene 1,2-epoxide + H(2)O + NAD(+) namespace: reaction xref: KEGG:R06398 "KEGG reaction" xref: RHEA:26096 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC06099 {cardinality="1"} ! (4R)-limonene relationship: has_input_compound UPa:UPC06099 ! (4R)-limonene relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC07271 ! (4R)-limonene 1,2-epoxide relationship: has_output_compound UPa:UPC07271 {cardinality="1"} ! (4R)-limonene 1,2-epoxide relationship: part_of UPa:UER00864 {cardinality="1", direction="LR", order="1"} ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 1/3 relationship: part_of UPa:UER00864 ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 1/3 [Term] id: UPa:UCR06399 name: (1S,2S,4R)-limonene-1,2-diol + NAD(+) = (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH namespace: reaction xref: KEGG:R06399 "KEGG reaction" xref: METACYC:RXN-9949 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:32386 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC07276 {cardinality="1"} ! (1S,2S,4R)-limonene-1,2-diol relationship: has_input_compound UPa:UPC07276 ! (1S,2S,4R)-limonene-1,2-diol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC11937 {cardinality="1"} ! (1S,4R)-1-hydroxylimonen-2-one relationship: has_output_compound UPa:UPC11937 ! (1S,4R)-1-hydroxylimonen-2-one relationship: part_of UPa:UER00866 {cardinality="1", direction="LR", order="1"} ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 3/3 relationship: part_of UPa:UER00866 ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 3/3 [Term] id: UPa:UCR06558 name: GTP + adenosylcobinamide = GDP + adenosylcobinamide phosphate namespace: reaction xref: KEGG:R06558 "KEGG reaction" xref: METACYC:RXN-14063 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:15768 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC06508 {cardinality="1"} ! adenosylcobinamide relationship: has_input_compound UPa:UPC06508 ! adenosylcobinamide relationship: has_output_compound UPa:UPC00035 ! GDP relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_output_compound UPa:UPC06509 {cardinality="1"} ! adenosylcobinamide phosphate relationship: has_output_compound UPa:UPC06509 ! adenosylcobinamide phosphate relationship: part_of UPa:UER00954 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00954 ! None [Term] id: UPa:UCR06601 name: 5-hydroxyisouric acid + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid namespace: reaction xref: KEGG:R06601 "KEGG reaction" xref: METACYC:3.5.2.17-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23739 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC11821 {cardinality="1"} ! 5-hydroxyisouric acid relationship: has_input_compound UPa:UPC11821 ! 5-hydroxyisouric acid relationship: has_output_compound UPa:UPC12248 {cardinality="1"} ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid relationship: has_output_compound UPa:UPC12248 ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid relationship: part_of UPa:UER00651 ! (S)-allantoin from urate: step 2/3 relationship: part_of UPa:UER00651 {cardinality="1", direction="LR", order="1"} ! (S)-allantoin from urate: step 2/3 [Term] id: UPa:UCR06604 name: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid = (S)-allantoin + CO(2) namespace: reaction xref: KEGG:R06604 "KEGG reaction" xref: METACYC:RXN-6201 "MetaCyc REACTION" {source="MetaCyc"} is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC12248 {cardinality="1"} ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid relationship: has_input_compound UPa:UPC12248 ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC02350 ! (S)-allantoin relationship: has_output_compound UPa:UPC02350 {cardinality="1"} ! (S)-allantoin relationship: part_of UPa:UER00652 ! (S)-allantoin from urate: step 3/3 relationship: part_of UPa:UER00652 {cardinality="1", direction="LR", order="1"} ! (S)-allantoin from urate: step 3/3 [Term] id: UPa:UCR06782 name: 3-phenylpropanoate + H(+) + NADH + O(2) = NAD(+) + cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol namespace: reaction xref: KEGG:R06782 "KEGG reaction" xref: METACYC:HCAMULTI-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20360 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC05629 ! 3-phenylpropanoate relationship: has_input_compound UPa:UPC05629 {cardinality="1"} ! 3-phenylpropanoate relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC11588 {cardinality="1"} ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol relationship: has_output_compound UPa:UPC11588 ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol relationship: part_of UPa:UER00792 ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate: step 1/2 relationship: part_of UPa:UER00792 {cardinality="1", direction="LR", order="1"} ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate: step 1/2 [Term] id: UPa:UCR06784 name: NAD(+) + cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH namespace: reaction xref: KEGG:R06784 "KEGG reaction" xref: METACYC:PHENPRODIOLDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25065 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC11588 {cardinality="1"} ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol relationship: has_input_compound UPa:UPC11588 ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC04044 ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC04044 {cardinality="1"} ! 3-(2,3-dihydroxyphenyl)propanoate relationship: part_of UPa:UER00793 ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate: step 2/2 relationship: part_of UPa:UER00793 {cardinality="1", direction="LR", order="1"} ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate: step 2/2 [Term] id: UPa:UCR06786 name: 3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+) namespace: reaction xref: KEGG:R06786 "KEGG reaction" xref: METACYC:MHPHYDROXY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24788 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC11457 {cardinality="1"} ! 3-(3-hydroxyphenyl)propanoate relationship: has_input_compound UPa:UPC11457 ! 3-(3-hydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC04044 ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC04044 {cardinality="1"} ! 3-(2,3-dihydroxyphenyl)propanoate relationship: part_of UPa:UER00791 {cardinality="1", direction="LR", order="1"} ! 3-(2,3-dihydroxyphenyl)propanoate from 3-(3-hydroxyphenyl)propanoate: step 1/1 relationship: part_of UPa:UER00791 ! 3-(2,3-dihydroxyphenyl)propanoate from 3-(3-hydroxyphenyl)propanoate: step 1/1 [Term] id: UPa:UCR06836 name: ATP + D-ribose 1,5-bisphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ADP namespace: reaction xref: KEGG:R06836 "KEGG reaction" xref: METACYC:RXN0-1401 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20112 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01151 {cardinality="1"} ! D-ribose 1,5-bisphosphate relationship: has_input_compound UPa:UPC01151 ! D-ribose 1,5-bisphosphate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UER00175 {cardinality="1", direction="LR", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3 relationship: part_of UPa:UER00175 ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3 [Term] id: UPa:UCR06837 name: alpha-D-ribose 1-phosphate = D-ribose 1,5-bisphosphate namespace: reaction xref: KEGG:R06837 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00620 {cardinality="1"} ! alpha-D-ribose 1-phosphate relationship: has_input_compound UPa:UPC00620 ! alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC01151 ! D-ribose 1,5-bisphosphate relationship: has_output_compound UPa:UPC01151 {cardinality="1"} ! D-ribose 1,5-bisphosphate relationship: part_of UPa:UER00174 {cardinality="1", direction="LR", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 2/3 relationship: part_of UPa:UER00174 ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 2/3 [Term] id: UPa:UCR06868 name: N-methylethanolamine phosphate + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + phosphodimethylethanolamine namespace: reaction xref: KEGG:R06868 "KEGG reaction" xref: METACYC:RXN-5642 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25324 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01210 {cardinality="1"} ! N-methylethanolamine phosphate relationship: has_input_compound UPa:UPC01210 ! N-methylethanolamine phosphate relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC13482 {cardinality="1"} ! phosphodimethylethanolamine relationship: has_output_compound UPa:UPC13482 ! phosphodimethylethanolamine relationship: part_of UPa:UER00738 ! phosphocholine from phosphoethanolamine: step 1/1 relationship: part_of UPa:UER00738 {cardinality="1", direction="LR", order="2"} ! phosphocholine from phosphoethanolamine: step 1/1 [Term] id: UPa:UCR06869 name: S-adenosyl-L-methionine + phosphodimethylethanolamine = S-adenosyl-L-homocysteine + phosphocholine namespace: reaction xref: KEGG:R06869 "KEGG reaction" xref: METACYC:RXN-5643 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25328 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC13482 {cardinality="1"} ! phosphodimethylethanolamine relationship: has_input_compound UPa:UPC13482 ! phosphodimethylethanolamine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00588 ! phosphocholine relationship: has_output_compound UPa:UPC00588 {cardinality="1"} ! phosphocholine relationship: part_of UPa:UER00738 ! phosphocholine from phosphoethanolamine: step 1/1 relationship: part_of UPa:UER00738 {cardinality="1", direction="LR", order="3"} ! phosphocholine from phosphoethanolamine: step 1/1 [Term] id: UPa:UCR06895 name: 2 S-adenosyl-L-methionine + coproporphyrinogen-III = 2 5'-deoxyadenosine + 2 CO(2) + 2 L-methionine + protoporphyrinogen-IX namespace: reaction xref: KEGG:R06895 "KEGG reaction" xref: METACYC:HEMN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15428 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC03263 {cardinality="1"} ! coproporphyrinogen-III relationship: has_input_compound UPa:UPC03263 ! coproporphyrinogen-III relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC01079 ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC01079 {cardinality="1"} ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC05198 ! 5'-deoxyadenosine relationship: has_output_compound UPa:UPC05198 {cardinality="1"} ! 5'-deoxyadenosine relationship: part_of UPa:UER00323 ! protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1 relationship: part_of UPa:UER00323 {cardinality="1", direction="LR", order="1"} ! protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1 [Term] id: UPa:UCR06897 name: 2-hydroxy-hept-2,4-diene-1,7-dioic acid + H(2)O = 2,4-dihydroxyhept-2-enedioic acid namespace: reaction xref: KEGG:R06897 "KEGG reaction" xref: RHEA:42075 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC05600 {cardinality="1"} ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid relationship: has_input_compound UPa:UPC05600 ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid relationship: has_output_compound UPa:UPC06201 {cardinality="1"} ! 2,4-dihydroxyhept-2-enedioic acid relationship: has_output_compound UPa:UPC06201 ! 2,4-dihydroxyhept-2-enedioic acid relationship: part_of UPa:UER00421 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 6/7 relationship: part_of UPa:UER00421 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 6/7 [Term] id: UPa:UCR06974 name: ATP + N(1)-(5-phospho-D-ribosyl)glycinamide + formate = ADP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate namespace: reaction xref: KEGG:R06974 "KEGG reaction" xref: METACYC:GARTRANSFORMYL2-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24832 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_input_compound UPa:UPC00058 ! formate relationship: has_input_compound UPa:UPC03838 ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_input_compound UPa:UPC03838 {cardinality="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC04376 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC04376 {cardinality="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:UER00127 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1 relationship: part_of UPa:UER00127 {cardinality="1", direction="LR", order="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1 [Term] id: UPa:UCR06975 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate namespace: reaction xref: KEGG:R06975 "KEGG reaction" xref: METACYC:RXN-10066 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24839 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_input_compound UPa:UPC00058 ! formate relationship: has_input_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC04734 {cardinality="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04734 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UER00134 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1 relationship: part_of UPa:UER00134 {cardinality="1", direction="LR", order="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1 [Term] id: UPa:UCR06977 name: L-aspartate 4-semialdehyde + L-glutamate = 2-oxoglutarate + L-2,4-diaminobutanoate namespace: reaction xref: KEGG:R06977 "KEGG reaction" xref: METACYC:R101-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11163 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC03283 {cardinality="1"} ! L-2,4-diaminobutanoate relationship: has_output_compound UPa:UPC03283 ! L-2,4-diaminobutanoate relationship: part_of UPa:UER00121 ! L-ectoine from L-aspartate 4-semialdehyde: step 1/3 relationship: part_of UPa:UER00121 {cardinality="1", direction="LR", order="1"} ! L-ectoine from L-aspartate 4-semialdehyde: step 1/3 relationship: part_of UPa:UER00731 ! 1,3-diaminopropane from L-aspartate 4-semialdehyde: step 1/2 relationship: part_of UPa:UER00731 {cardinality="1", direction="LR", order="1"} ! 1,3-diaminopropane from L-aspartate 4-semialdehyde: step 1/2 [Term] id: UPa:UCR06978 name: L-2,4-diaminobutanoate + acetyl-CoA = CoA + N(4)-acetyl-L-2,4-diaminobutyric acid namespace: reaction xref: KEGG:R06978 "KEGG reaction" xref: METACYC:R102-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16904 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC03283 ! L-2,4-diaminobutanoate relationship: has_input_compound UPa:UPC03283 {cardinality="1"} ! L-2,4-diaminobutanoate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC06442 {cardinality="1"} ! N(4)-acetyl-L-2,4-diaminobutyric acid relationship: has_output_compound UPa:UPC06442 ! N(4)-acetyl-L-2,4-diaminobutyric acid relationship: part_of UPa:UER00122 ! L-ectoine from L-aspartate 4-semialdehyde: step 2/3 relationship: part_of UPa:UER00122 {cardinality="1", direction="LR", order="1"} ! L-ectoine from L-aspartate 4-semialdehyde: step 2/3 [Term] id: UPa:UCR06979 name: N(4)-acetyl-L-2,4-diaminobutyric acid = H(2)O + L-ectoine namespace: reaction xref: KEGG:R06979 "KEGG reaction" xref: METACYC:R103-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17284 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC06442 ! N(4)-acetyl-L-2,4-diaminobutyric acid relationship: has_input_compound UPa:UPC06442 {cardinality="1"} ! N(4)-acetyl-L-2,4-diaminobutyric acid relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC06231 {cardinality="1"} ! L-ectoine relationship: has_output_compound UPa:UPC06231 ! L-ectoine relationship: part_of UPa:UER00123 ! L-ectoine from L-aspartate 4-semialdehyde: step 3/3 relationship: part_of UPa:UER00123 {cardinality="1", direction="LR", order="1"} ! L-ectoine from L-aspartate 4-semialdehyde: step 3/3 [Term] id: UPa:UCR06982 name: formaldehyde + glutathione = S-(hydroxymethyl)glutathione namespace: reaction xref: KEGG:R06982 "KEGG reaction" xref: METACYC:RXN-2961 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22491 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00051 ! glutathione relationship: has_input_compound UPa:UPC00051 {cardinality="1"} ! glutathione relationship: has_input_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_input_compound UPa:UPC00067 ! formaldehyde relationship: has_output_compound UPa:UPC14180 ! S-(hydroxymethyl)glutathione relationship: has_output_compound UPa:UPC14180 {cardinality="1"} ! S-(hydroxymethyl)glutathione relationship: part_of UPa:UER00621 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (glutathione route): step 1/3 relationship: part_of UPa:UER00621 ! formate from formaldehyde (glutathione route): step 1/3 [Term] id: UPa:UCR06983 name: NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione namespace: reaction xref: KEGG:R06983 "KEGG reaction" xref: METACYC:RXN-2962 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:19988 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC14180 ! S-(hydroxymethyl)glutathione relationship: has_input_compound UPa:UPC14180 {cardinality="1"} ! S-(hydroxymethyl)glutathione relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC01031 {cardinality="1"} ! S-formylglutathione relationship: has_output_compound UPa:UPC01031 ! S-formylglutathione relationship: part_of UPa:UER00971 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00971 ! None [Term] id: UPa:UCR06987 name: 2-oxobutanoate + CoA = formate + propanoyl-CoA namespace: reaction xref: KEGG:R06987 "KEGG reaction" xref: METACYC:KETOBUTFORMLY-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28057 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00109 ! 2-oxobutanoate relationship: has_input_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00100 ! propanoyl-CoA relationship: has_output_compound UPa:UPC00100 {cardinality="1"} ! propanoyl-CoA relationship: part_of UPa:UER00508 ! propanoate from L-threonine: step 2/4 relationship: part_of UPa:UER00508 {cardinality="1", direction="LR", order="1"} ! propanoate from L-threonine: step 2/4 [Term] id: UPa:UCR06989 name: cis,cis-muconate = (S)-5-oxo-2,5-dihydro-2-furylacetic acid namespace: reaction xref: KEGG:R06989 "KEGG reaction" xref: RHEA:30034 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC02480 {cardinality="1"} ! cis,cis-muconate relationship: has_input_compound UPa:UPC02480 ! cis,cis-muconate relationship: has_output_compound UPa:UPC14610 {cardinality="1"} ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid relationship: has_output_compound UPa:UPC14610 ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid relationship: part_of UPa:UER00259 ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 2/3 relationship: part_of UPa:UER00259 {cardinality="1", direction="LR", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 2/3 [Term] id: UPa:UCR06990 name: (S)-5-oxo-2,5-dihydro-2-furylacetic acid = 5-oxo-4,5-dihydro-2-furylacetate namespace: reaction xref: KEGG:R06990 "KEGG reaction" xref: RHEA:12351 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC14610 {cardinality="1"} ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid relationship: has_input_compound UPa:UPC14610 ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid relationship: has_output_compound UPa:UPC03586 {cardinality="1"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_output_compound UPa:UPC03586 ! 5-oxo-4,5-dihydro-2-furylacetate relationship: part_of UPa:UER00260 {cardinality="1", direction="LR", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 3/3 relationship: part_of UPa:UER00260 ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 3/3 [Term] id: UPa:UCR07125 name: 3-dehydro-L-gulonate 6-phosphate + H(+) = CO(2) + L-xylulose 5-phosphate namespace: reaction xref: KEGG:R07125 "KEGG reaction" xref: METACYC:RXN0-705 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14356 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC14899 ! 3-dehydro-L-gulonate 6-phosphate relationship: has_input_compound UPa:UPC14899 {cardinality="1"} ! 3-dehydro-L-gulonate 6-phosphate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC03291 ! L-xylulose 5-phosphate relationship: has_output_compound UPa:UPC03291 {cardinality="1"} ! L-xylulose 5-phosphate relationship: part_of UPa:UER00378 ! D-xylulose 5-phosphate from L-ascorbate: step 2/4 relationship: part_of UPa:UER00378 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-ascorbate: step 2/4 [Term] id: UPa:UCR07133 name: D-sorbitol 6-phosphate + NAD(+) = D-fructose 6-phosphate + H(+) + NADH namespace: reaction xref: KEGG:R07133 "KEGG reaction" xref: METACYC:SORB6PDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19840 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC01096 ! D-sorbitol 6-phosphate relationship: has_input_compound UPa:UPC01096 {cardinality="1"} ! D-sorbitol 6-phosphate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: part_of UPa:UER00783 ! D-fructose 6-phosphate from D-sorbitol 6-phosphate: step 1/1 relationship: part_of UPa:UER00783 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from D-sorbitol 6-phosphate: step 1/1 [Term] id: UPa:UCR07136 name: (R)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH namespace: reaction xref: KEGG:R07136 "KEGG reaction" xref: METACYC:R230-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15536 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC11537 {cardinality="1"} ! (R)-3-sulfolactate relationship: has_input_compound UPa:UPC11537 ! (R)-3-sulfolactate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC05528 ! 3-sulfopyruvate relationship: has_output_compound UPa:UPC05528 {cardinality="1"} ! 3-sulfopyruvate relationship: part_of UPa:UER00471 ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 3/4 relationship: part_of UPa:UER00471 {cardinality="1", direction="LR", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 3/4 [Term] id: UPa:UCR07140 name: NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione namespace: reaction xref: KEGG:R07140 "KEGG reaction" xref: METACYC:RXN-2962 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19984 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC14180 ! S-(hydroxymethyl)glutathione relationship: has_input_compound UPa:UPC14180 {cardinality="1"} ! S-(hydroxymethyl)glutathione relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01031 ! S-formylglutathione relationship: has_output_compound UPa:UPC01031 {cardinality="1"} ! S-formylglutathione relationship: part_of UPa:UER00972 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00972 ! None [Term] id: UPa:UCR07170 name: (R)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2) namespace: reaction xref: KEGG:R07170 "KEGG reaction" xref: METACYC:R-6-HYDROXYNICOTINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10015 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC03043 {cardinality="1"} ! (R)-6-hydroxynicotine relationship: has_input_compound UPa:UPC03043 ! (R)-6-hydroxynicotine relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC01297 ! 6-hydroxypseudooxynicotine relationship: has_output_compound UPa:UPC01297 {cardinality="1"} ! 6-hydroxypseudooxynicotine relationship: part_of UPa:UER00488 ! 6-hydroxypseudooxynicotine from nicotine (R-isomer route): step 2/2 relationship: part_of UPa:UER00488 {cardinality="1", direction="LR", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (R-isomer route): step 2/2 [Term] id: UPa:UCR07211 name: L-phenylalanine + O(2) + tetrahydrobiopterin = 4a-hydroxytetrahydrobiopterin + L-tyrosine namespace: reaction xref: KEGG:R07211 "KEGG reaction" xref: METACYC:PHENYLALANINE-4-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20276 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine relationship: has_input_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: has_input_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: has_output_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC15522 ! 4a-hydroxytetrahydrobiopterin relationship: has_output_compound UPa:UPC15522 {cardinality="1"} ! 4a-hydroxytetrahydrobiopterin relationship: part_of UPa:UER00337 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 1/6 relationship: part_of UPa:UER00337 ! acetoacetate and fumarate from L-phenylalanine: step 1/6 [Term] id: UPa:UCR07213 name: L-tryptophan + O(2) + tetrahydrobiopterin = 4a-hydroxytetrahydrobiopterin + 5-hydroxy-L-tryptophan namespace: reaction xref: KEGG:R07213 "KEGG reaction" xref: METACYC:TRYPTOPHAN-5-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16712 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan relationship: has_input_compound UPa:UPC00078 ! L-tryptophan relationship: has_input_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: has_input_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00643 ! 5-hydroxy-L-tryptophan relationship: has_output_compound UPa:UPC00643 {cardinality="1"} ! 5-hydroxy-L-tryptophan relationship: has_output_compound UPa:UPC15522 ! 4a-hydroxytetrahydrobiopterin relationship: has_output_compound UPa:UPC15522 {cardinality="1"} ! 4a-hydroxytetrahydrobiopterin relationship: part_of UPa:UER00799 ! serotonin from L-tryptophan: step 1/2 relationship: part_of UPa:UER00799 {cardinality="1", direction="LR", order="1"} ! serotonin from L-tryptophan: step 1/2 [Term] id: UPa:UCR07214 name: 1-aminocyclopropanecarboxylate + L-ascorbate + O(2) = CO(2) + 2 H(2)O + L-dehydroascorbate + ethylene + hydrogen cyanide namespace: reaction xref: KEGG:R07214 "KEGG reaction" xref: METACYC:ETHYL-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23643 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_input_compound UPa:UPC00072 ! L-ascorbate relationship: has_input_compound UPa:UPC01234 {cardinality="1"} ! 1-aminocyclopropanecarboxylate relationship: has_input_compound UPa:UPC01234 ! 1-aminocyclopropanecarboxylate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00177 ! hydrogen cyanide relationship: has_output_compound UPa:UPC00177 {cardinality="1"} ! hydrogen cyanide relationship: has_output_compound UPa:UPC05422 ! L-dehydroascorbate relationship: has_output_compound UPa:UPC05422 {cardinality="1"} ! L-dehydroascorbate relationship: has_output_compound UPa:UPC06547 {cardinality="1"} ! ethylene relationship: has_output_compound UPa:UPC06547 ! ethylene relationship: part_of UPa:UER00563 {cardinality="1", direction="LR", order="1"} ! ethylene from S-adenosyl-L-methionine: step 2/2 relationship: part_of UPa:UER00563 ! ethylene from S-adenosyl-L-methionine: step 2/2 [Term] id: UPa:UCR07219 name: H(2)O + NADP(+) + dimethylallyl diphosphate = (2E)-4-hydroxy-3-methylbutenyl diphosphate + H(+) + NADPH namespace: reaction xref: KEGG:R07219 "KEGG reaction" xref: METACYC:RXN0-884 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24828 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00235 ! dimethylallyl diphosphate relationship: has_input_compound UPa:UPC00235 {cardinality="1"} ! dimethylallyl diphosphate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC11811 ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_output_compound UPa:UPC11811 {cardinality="1"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: part_of UPa:UER00105 ! dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1 relationship: part_of UPa:UER00105 {cardinality="1", direction="RL", order="1"} ! dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1 [Term] id: UPa:UCR07243 name: S-adenosyl-L-methionine + sarcosine = N,N-dimethylglycine + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R07243 "KEGG reaction" xref: METACYC:RXN-9679 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15456 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: has_input_compound UPa:UPC00213 ! sarcosine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC01026 ! N,N-dimethylglycine relationship: has_output_compound UPa:UPC01026 {cardinality="1"} ! N,N-dimethylglycine relationship: part_of UPa:UER00382 ! betaine from glycine: step 2/3 relationship: part_of UPa:UER00382 {cardinality="1", direction="LR", order="1"} ! betaine from glycine: step 2/3 [Term] id: UPa:UCR07244 name: N,N-dimethylglycine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + betaine namespace: reaction xref: KEGG:R07244 "KEGG reaction" xref: METACYC:RXN-9680 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10075 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01026 ! N,N-dimethylglycine relationship: has_input_compound UPa:UPC01026 {cardinality="1"} ! N,N-dimethylglycine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00719 ! betaine relationship: has_output_compound UPa:UPC00719 {cardinality="1"} ! betaine relationship: part_of UPa:UER00383 ! betaine from glycine: step 3/3 relationship: part_of UPa:UER00383 {cardinality="1", direction="LR", order="1"} ! betaine from glycine: step 3/3 [Term] id: UPa:UCR07262 name: 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O = 1,4-dihydroxy-2-naphthoate + CoA namespace: reaction xref: KEGG:R07262 "KEGG reaction" xref: METACYC:RXN-9311 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26312 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC15547 ! 1,4-dihydroxy-2-naphthoyl-CoA relationship: has_input_compound UPa:UPC15547 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC03657 ! 1,4-dihydroxy-2-naphthoate relationship: has_output_compound UPa:UPC03657 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoate relationship: part_of UPa:UER01033 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7 relationship: part_of UPa:UER01033 ! 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7 [Term] id: UPa:UCR07263 name: 2-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O namespace: reaction xref: KEGG:R07263 "KEGG reaction" xref: METACYC:NAPHTHOATE-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26565 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03160 {cardinality="1"} ! 2-succinylbenzoyl-CoA relationship: has_input_compound UPa:UPC03160 ! 2-succinylbenzoyl-CoA relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC15547 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoyl-CoA relationship: has_output_compound UPa:UPC15547 ! 1,4-dihydroxy-2-naphthoyl-CoA relationship: part_of UPa:UER00167 ! 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7 relationship: part_of UPa:UER00167 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7 [Term] id: UPa:UCR07276 name: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate namespace: reaction xref: KEGG:R07276 "KEGG reaction" xref: METACYC:PREPHENATE-TRANSAMINE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22883 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_input_compound UPa:UPC00826 ! L-arogenate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00254 ! prephenate relationship: has_output_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: part_of UPa:UER00343 ! L-arogenate from prephenate (L-Glu route): step 1/1 relationship: part_of UPa:UER00343 {cardinality="1", direction="RL", order="1"} ! L-arogenate from prephenate (L-Glu route): step 1/1 [Term] id: UPa:UCR07280 name: 5-amino-6-(5-phosphoribitylamino)uracil + H(2)O = 5-amino-6-(D-ribitylamino)uracil + phosphate namespace: reaction xref: KEGG:R07280 "KEGG reaction" xref: METACYC:RIBOPHOSPHAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25200 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04454 ! 5-amino-6-(5-phosphoribitylamino)uracil relationship: has_input_compound UPa:UPC04454 {cardinality="1"} ! 5-amino-6-(5-phosphoribitylamino)uracil relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC04732 ! 5-amino-6-(D-ribitylamino)uracil relationship: has_output_compound UPa:UPC04732 {cardinality="1"} ! 5-amino-6-(D-ribitylamino)uracil relationship: part_of UPa:UER00403 {cardinality="1", direction="LR", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 4/4 relationship: part_of UPa:UER00403 ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 4/4 [Term] id: UPa:UCR07281 name: D-ribulose 5-phosphate = 2-hydroxy-3-oxobutyl phosphate + formate namespace: reaction xref: KEGG:R07281 "KEGG reaction" xref: METACYC:DIOHBUTANONEPSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18460 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC15556 ! 2-hydroxy-3-oxobutyl phosphate relationship: has_output_compound UPa:UPC15556 {cardinality="1"} ! 2-hydroxy-3-oxobutyl phosphate relationship: part_of UPa:UER00399 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1 relationship: part_of UPa:UER00399 ! 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1 [Term] id: UPa:UCR07290 name: formyl-CoA + oxalate = formate + oxalyl-CoA namespace: reaction xref: KEGG:R07290 "KEGG reaction" xref: METACYC:RXN0-1382 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16548 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00209 ! oxalate relationship: has_input_compound UPa:UPC00209 {cardinality="1"} ! oxalate relationship: has_input_compound UPa:UPC00798 ! formyl-CoA relationship: has_input_compound UPa:UPC00798 {cardinality="1"} ! formyl-CoA relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00313 {cardinality="1"} ! oxalyl-CoA relationship: has_output_compound UPa:UPC00313 ! oxalyl-CoA relationship: part_of UPa:UER00598 {cardinality="1", direction="LR", order="1"} ! CO(2) and formate from oxalate: step 1/2 relationship: part_of UPa:UER00598 ! CO(2) and formate from oxalate: step 1/2 [Term] id: UPa:UCR07305 name: H(2)O + cyanurate = CO(2) + biuret namespace: reaction xref: KEGG:R07305 "KEGG reaction" xref: METACYC:R468-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14644 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC06554 {cardinality="1"} ! cyanurate relationship: has_input_compound UPa:UPC06554 ! cyanurate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC06555 ! biuret relationship: has_output_compound UPa:UPC06555 {cardinality="1"} ! biuret relationship: part_of UPa:UER00502 {cardinality="1", direction="LR", order="1"} ! biuret from cyanurate: step 1/1 relationship: part_of UPa:UER00502 ! biuret from cyanurate: step 1/1 [Term] id: UPa:UCR07307 name: 2 H(2)O + dCTP = NH(3) + dUMP + diphosphate namespace: reaction xref: KEGG:R07307 "KEGG reaction" xref: METACYC:3.5.4.30-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19208 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00458 {cardinality="1"} ! dCTP relationship: has_input_compound UPa:UPC00458 ! dCTP relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00365 {cardinality="1"} ! dUMP relationship: has_output_compound UPa:UPC00365 ! dUMP relationship: part_of UPa:UER00667 ! dUMP from dCTP: step 1/1 relationship: part_of UPa:UER00667 {cardinality="1", direction="LR", order="1"} ! dUMP from dCTP: step 1/1 [Term] id: UPa:UCR07320 name: violaxanthin = capsorubin namespace: reaction xref: KEGG:R07320 "KEGG reaction" xref: METACYC:RXN-7946 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21755 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC08614 ! violaxanthin relationship: has_input_compound UPa:UPC08614 {cardinality="1"} ! violaxanthin relationship: has_output_compound UPa:UPC08585 ! capsorubin relationship: has_output_compound UPa:UPC08585 {cardinality="1"} ! capsorubin relationship: part_of UPa:UER00775 ! capsorubin from violaxanthin: step 1/1 relationship: part_of UPa:UER00775 {cardinality="1", direction="LR", order="1"} ! capsorubin from violaxanthin: step 1/1 [Term] id: UPa:UCR07321 name: antheraxanthin = capsanthin namespace: reaction xref: KEGG:R07321 "KEGG reaction" xref: METACYC:RXN-7947 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17376 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC08579 {cardinality="1"} ! antheraxanthin relationship: has_input_compound UPa:UPC08579 ! antheraxanthin relationship: has_output_compound UPa:UPC08584 ! capsanthin relationship: has_output_compound UPa:UPC08584 {cardinality="1"} ! capsanthin relationship: part_of UPa:UER00774 ! capsanthin from antheraxanthin: step 1/1 relationship: part_of UPa:UER00774 {cardinality="1", direction="LR", order="1"} ! capsanthin from antheraxanthin: step 1/1 [Term] id: UPa:UCR07324 name: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate namespace: reaction xref: KEGG:R07324 "KEGG reaction" xref: METACYC:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10719 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC04006 {cardinality="1"} ! 1D-myo-inositol 3-phosphate relationship: has_output_compound UPa:UPC04006 ! 1D-myo-inositol 3-phosphate relationship: part_of UPa:UER00787 ! myo-inositol from D-glucose 6-phosphate: step 1/2 relationship: part_of UPa:UER00787 {cardinality="1", direction="LR", order="1"} ! myo-inositol from D-glucose 6-phosphate: step 1/2 [Term] id: UPa:UCR07364 name: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate namespace: reaction xref: KEGG:R07364 "KEGG reaction" xref: METACYC:R147-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24507 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC15606 ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one relationship: has_input_compound UPa:UPC15606 {cardinality="1"} ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC01180 {cardinality="1"} ! 4-methylthio-2-oxobutanoate relationship: has_output_compound UPa:UPC01180 ! 4-methylthio-2-oxobutanoate relationship: part_of UPa:UER00878 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6 relationship: part_of UPa:UER00878 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6 [Term] id: UPa:UCR07392 name: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O namespace: reaction xref: KEGG:R07392 "KEGG reaction" xref: METACYC:R145-RXN "MetaCyc REACTION" {source="MetaCyc"} is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04582 {cardinality="1"} ! S-methyl-5-thio-D-ribulose 1-phosphate relationship: has_input_compound UPa:UPC04582 ! S-methyl-5-thio-D-ribulose 1-phosphate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC15650 ! 5-(methylthio)-2,3-dioxopentyl phosphate relationship: has_output_compound UPa:UPC15650 {cardinality="1"} ! 5-(methylthio)-2,3-dioxopentyl phosphate relationship: part_of UPa:UER00875 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6 relationship: part_of UPa:UER00875 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6 [Term] id: UPa:UCR07393 name: 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate namespace: reaction xref: KEGG:R07393 "KEGG reaction" xref: METACYC:R82-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18772 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC15650 ! 5-(methylthio)-2,3-dioxopentyl phosphate relationship: has_input_compound UPa:UPC15650 {cardinality="1"} ! 5-(methylthio)-2,3-dioxopentyl phosphate relationship: has_output_compound UPa:UPC15651 {cardinality="1"} ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate relationship: has_output_compound UPa:UPC15651 ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate relationship: part_of UPa:UER00876 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6 relationship: part_of UPa:UER00876 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6 [Term] id: UPa:UCR07394 name: 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate + H(2)O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate namespace: reaction xref: KEGG:R07394 "KEGG reaction" xref: METACYC:R83-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14484 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC15651 ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate relationship: has_input_compound UPa:UPC15651 {cardinality="1"} ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC15606 ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one relationship: has_output_compound UPa:UPC15606 {cardinality="1"} ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one relationship: part_of UPa:UER00877 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6 relationship: part_of UPa:UER00877 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6 [Term] id: UPa:UCR07396 name: 4-methylthio-2-oxobutanoate + L-glutamate = 2-oxoglutarate + L-methionine namespace: reaction xref: KEGG:R07396 "KEGG reaction" xref: RHEA:25799 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC01180 {cardinality="1"} ! 4-methylthio-2-oxobutanoate relationship: has_input_compound UPa:UPC01180 ! 4-methylthio-2-oxobutanoate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: part_of UPa:UER00879 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6 relationship: part_of UPa:UER00879 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6 [Term] id: UPa:UCR07399 name: H(2)O + acetyl-CoA + pyruvate = (R)-citramalate + CoA namespace: reaction xref: KEGG:R07399 "KEGG reaction" xref: METACYC:RXN-7743 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19048 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC02612 ! (R)-citramalate relationship: has_output_compound UPa:UPC02612 {cardinality="1"} ! (R)-citramalate relationship: part_of UPa:UER00066 {cardinality="1", direction="LR", order="1"} ! 2-oxobutanoate from pyruvate: step 1/3 relationship: part_of UPa:UER00066 ! 2-oxobutanoate from pyruvate: step 1/3 [Term] id: UPa:UCR07403 name: H(+) + NADPH + O(2) + indole = H(2)O + NADP(+) + indolin-2-one namespace: reaction xref: KEGG:R07403 "KEGG reaction" xref: METACYC:RXN-6681 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:31902 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00463 {cardinality="1"} ! indole relationship: has_input_compound UPa:UPC00463 ! indole relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC12312 {cardinality="1"} ! indolin-2-one relationship: has_output_compound UPa:UPC12312 ! indolin-2-one relationship: part_of UPa:UER00848 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 2/5 relationship: part_of UPa:UER00848 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 2/5 [Term] id: UPa:UCR07404 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + phosphate namespace: reaction xref: KEGG:R07404 "KEGG reaction" xref: METACYC:RXN0-742 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19320 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_input_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_input_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC15667 {cardinality="1"} ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC15667 ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:UER00942 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2 relationship: part_of UPa:UER00942 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2 [Term] id: UPa:UCR07405 name: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate namespace: reaction xref: KEGG:R07405 "KEGG reaction" xref: METACYC:RXN0-743 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13196 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC15667 ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole relationship: has_input_compound UPa:UPC15667 {cardinality="1"} ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC04751 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_output_compound UPa:UPC04751 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: part_of UPa:UER00943 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2 relationship: part_of UPa:UER00943 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2 [Term] id: UPa:UCR07406 name: 2-amino-3-oxo-4-phosphonooxybutyrate = 3-amino-2-oxopropyl phosphate + CO(2) namespace: reaction xref: KEGG:R07406 "KEGG reaction" xref: METACYC:RXN-8447 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25142 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC07335 ! 2-amino-3-oxo-4-phosphonooxybutyrate relationship: has_input_compound UPa:UPC07335 {cardinality="1"} ! 2-amino-3-oxo-4-phosphonooxybutyrate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC11638 ! 3-amino-2-oxopropyl phosphate relationship: has_output_compound UPa:UPC11638 {cardinality="1"} ! 3-amino-2-oxopropyl phosphate relationship: part_of UPa:UER00312 {cardinality="1", direction="LR", order="2"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5 relationship: part_of UPa:UER00312 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5 [Term] id: UPa:UCR07407 name: L-aspartate + NADP(+) = H(+) + NADPH + iminoaspartate namespace: reaction xref: KEGG:R07407 "KEGG reaction" xref: RHEA:42447 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate relationship: has_output_compound UPa:UPC05840 ! iminoaspartate relationship: part_of UPa:UER00964 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00964 ! None [Term] id: UPa:UCR07409 name: 2 H(+) + O(2) + choline + 2 reduced ferredoxin = 2 H(2)O + betaine aldehyde + 2 oxidized ferredoxin namespace: reaction xref: KEGG:R07409 "KEGG reaction" xref: RHEA:17772 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_input_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin relationship: has_input_compound UPa:UPC00138 ! reduced ferredoxin relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00139 ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde relationship: part_of UPa:UER00430 {cardinality="1", direction="LR", order="1"} ! betaine aldehyde from choline (monooxygenase route): step 1/1 relationship: part_of UPa:UER00430 ! betaine aldehyde from choline (monooxygenase route): step 1/1 [Term] id: UPa:UCR07410 name: L-aspartate + NAD(+) = H(+) + NADH + iminoaspartate namespace: reaction xref: KEGG:R07410 "KEGG reaction" xref: RHEA:42443 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05840 ! iminoaspartate relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate relationship: part_of UPa:UER00963 ! None relationship: part_of UPa:UER00963 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR07411 name: H(2)O + farnesyl diphosphate + protoheme = diphosphate + heme O namespace: reaction xref: KEGG:R07411 "KEGG reaction" xref: METACYC:HEMEOSYN-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:28073 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00032 {cardinality="1"} ! protoheme relationship: has_input_compound UPa:UPC00032 ! protoheme relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC15672 ! heme O relationship: has_output_compound UPa:UPC15672 {cardinality="1"} ! heme O relationship: part_of UPa:UER00712 ! heme O from protoheme: step 1/1 relationship: part_of UPa:UER00712 {cardinality="1", direction="LR", order="1"} ! heme O from protoheme: step 1/1 [Term] id: UPa:UCR07412 name: heme O = heme A namespace: reaction xref: KEGG:R07412 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC15672 {cardinality="1"} ! heme O relationship: has_input_compound UPa:UPC15672 ! heme O relationship: has_output_compound UPa:UPC15670 ! heme A relationship: has_output_compound UPa:UPC15670 {cardinality="1"} ! heme A relationship: part_of UPa:UER00713 ! heme A from heme O: step 1/1 relationship: part_of UPa:UER00713 {cardinality="1", direction="LR", order="1"} ! heme A from heme O: step 1/1 [Term] id: UPa:UCR07414 name: ATP + L-glutamate + putrescine = ADP + gamma-L-glutamylputrescine + phosphate namespace: reaction xref: KEGG:R07414 "KEGG reaction" xref: METACYC:RXN0-3901 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13636 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC15699 ! gamma-L-glutamylputrescine relationship: has_output_compound UPa:UPC15699 {cardinality="1"} ! gamma-L-glutamylputrescine relationship: part_of UPa:UER00880 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanoate from putrescine: step 1/4 relationship: part_of UPa:UER00880 ! 4-aminobutanoate from putrescine: step 1/4 [Term] id: UPa:UCR07415 name: H(2)O + O(2) + gamma-L-glutamylputrescine = H(2)O(2) + NH(3) + gamma-glutamyl-4-aminobutanal namespace: reaction xref: KEGG:R07415 "KEGG reaction" xref: RHEA:28417 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC15699 ! gamma-L-glutamylputrescine relationship: has_input_compound UPa:UPC15699 {cardinality="1"} ! gamma-L-glutamylputrescine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC15700 ! gamma-glutamyl-4-aminobutanal relationship: has_output_compound UPa:UPC15700 {cardinality="1"} ! gamma-glutamyl-4-aminobutanal relationship: part_of UPa:UER00881 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanoate from putrescine: step 2/4 relationship: part_of UPa:UER00881 ! 4-aminobutanoate from putrescine: step 2/4 [Term] id: UPa:UCR07417 name: H(2)O + NAD(+) + gamma-glutamyl-4-aminobutanal = 4-(L-gamma-glutamylamino)butanoic acid + H(+) + NADH namespace: reaction xref: KEGG:R07417 "KEGG reaction" xref: RHEA:42343 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC15700 ! gamma-glutamyl-4-aminobutanal relationship: has_input_compound UPa:UPC15700 {cardinality="1"} ! gamma-glutamyl-4-aminobutanal relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC15767 ! 4-(L-gamma-glutamylamino)butanoic acid relationship: has_output_compound UPa:UPC15767 {cardinality="1"} ! 4-(L-gamma-glutamylamino)butanoic acid relationship: part_of UPa:UER00989 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00989 ! None [Term] id: UPa:UCR07418 name: H(2)O + NADP(+) + gamma-glutamyl-4-aminobutanal = 4-(L-gamma-glutamylamino)butanoic acid + H(+) + NADPH namespace: reaction xref: KEGG:R07418 "KEGG reaction" xref: METACYC:RXN0-3922 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28413 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC15700 ! gamma-glutamyl-4-aminobutanal relationship: has_input_compound UPa:UPC15700 {cardinality="1"} ! gamma-glutamyl-4-aminobutanal relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC15767 {cardinality="1"} ! 4-(L-gamma-glutamylamino)butanoic acid relationship: has_output_compound UPa:UPC15767 ! 4-(L-gamma-glutamylamino)butanoic acid relationship: part_of UPa:UER00990 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER00990 ! None [Term] id: UPa:UCR07419 name: 4-(L-gamma-glutamylamino)butanoic acid + H(2)O = 4-aminobutanoate + L-glutamate namespace: reaction xref: KEGG:R07419 "KEGG reaction" xref: METACYC:RXN0-3942 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19740 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC15767 ! 4-(L-gamma-glutamylamino)butanoic acid relationship: has_input_compound UPa:UPC15767 {cardinality="1"} ! 4-(L-gamma-glutamylamino)butanoic acid relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00334 ! 4-aminobutanoate relationship: has_output_compound UPa:UPC00334 {cardinality="1"} ! 4-aminobutanoate relationship: part_of UPa:UER00883 ! 4-aminobutanoate from putrescine: step 4/4 relationship: part_of UPa:UER00883 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanoate from putrescine: step 4/4 [Term] id: UPa:UCR07421 name: H(+) + NADPH + O(2) + indolin-2-one = 3-hydroxyindolin-2-one + H(2)O + NADP(+) namespace: reaction xref: KEGG:R07421 "KEGG reaction" xref: METACYC:RXN-6682 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:31922 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC12312 ! indolin-2-one relationship: has_input_compound UPa:UPC12312 {cardinality="1"} ! indolin-2-one relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC11130 {cardinality="1"} ! 3-hydroxyindolin-2-one relationship: has_output_compound UPa:UPC11130 ! 3-hydroxyindolin-2-one relationship: part_of UPa:UER00849 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 3/5 relationship: part_of UPa:UER00849 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 3/5 [Term] id: UPa:UCR07422 name: 3-hydroxyindolin-2-one + H(+) + NADPH + O(2) = 2-hydroxy-1,4-benzoxazin-3-one + H(2)O + NADP(+) namespace: reaction xref: KEGG:R07422 "KEGG reaction" xref: METACYC:RXN-6683 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:31930 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC11130 ! 3-hydroxyindolin-2-one relationship: has_input_compound UPa:UPC11130 {cardinality="1"} ! 3-hydroxyindolin-2-one relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC15769 {cardinality="1"} ! 2-hydroxy-1,4-benzoxazin-3-one relationship: has_output_compound UPa:UPC15769 ! 2-hydroxy-1,4-benzoxazin-3-one relationship: part_of UPa:UER00850 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 4/5 relationship: part_of UPa:UER00850 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 4/5 [Term] id: UPa:UCR07423 name: 2-hydroxy-1,4-benzoxazin-3-one + H(+) + NADPH + O(2) = 2,4-dihydroxy-1,4-benzoxazin-3-one + H(2)O + NADP(+) namespace: reaction xref: KEGG:R07423 "KEGG reaction" xref: METACYC:RXN-6684 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:31942 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC15769 {cardinality="1"} ! 2-hydroxy-1,4-benzoxazin-3-one relationship: has_input_compound UPa:UPC15769 ! 2-hydroxy-1,4-benzoxazin-3-one relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC15770 ! 2,4-dihydroxy-1,4-benzoxazin-3-one relationship: has_output_compound UPa:UPC15770 {cardinality="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one relationship: part_of UPa:UER00851 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 5/5 relationship: part_of UPa:UER00851 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 5/5 [Term] id: UPa:UCR07476 name: (2R)-O-phospho-3-sulfolactic acid = phosphoenolpyruvate + sulfite namespace: reaction xref: KEGG:R07476 "KEGG reaction" xref: METACYC:4.4.1.19-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22787 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC11536 {cardinality="1"} ! (2R)-O-phospho-3-sulfolactic acid relationship: has_input_compound UPa:UPC11536 ! (2R)-O-phospho-3-sulfolactic acid relationship: has_output_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: has_output_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_output_compound UPa:UPC00094 ! sulfite relationship: part_of UPa:UER00469 {cardinality="1", direction="RL", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 1/4 relationship: part_of UPa:UER00469 ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 1/4 [Term] id: UPa:UCR07494 name: 4alpha-methylzymosterol-4-carboxylic acid + NADP(+) = 3-dehydro-4-methylzymosterol + CO(2) + H(+) + NADPH namespace: reaction xref: KEGG:R07494 "KEGG reaction" xref: METACYC:RXN66-313 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:33450 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC15808 ! 4alpha-methylzymosterol-4-carboxylic acid relationship: has_input_compound UPa:UPC15808 {cardinality="1"} ! 4alpha-methylzymosterol-4-carboxylic acid relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC15816 ! 3-dehydro-4-methylzymosterol relationship: has_output_compound UPa:UPC15816 {cardinality="1"} ! 3-dehydro-4-methylzymosterol relationship: part_of UPa:UER00757 ! zymosterol from lanosterol: step 4/6 relationship: part_of UPa:UER00757 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 4/6 [Term] id: UPa:UCR07495 name: 3-dehydro-4-methylzymosterol + H(+) + NADPH = 4-alpha-methylzymosterol + NADP(+) namespace: reaction xref: KEGG:R07495 "KEGG reaction" xref: METACYC:RXN66-314 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:36382 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC15816 ! 3-dehydro-4-methylzymosterol relationship: has_input_compound UPa:UPC15816 {cardinality="1"} ! 3-dehydro-4-methylzymosterol relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC05103 ! 4-alpha-methylzymosterol relationship: has_output_compound UPa:UPC05103 {cardinality="1"} ! 4-alpha-methylzymosterol relationship: part_of UPa:UER00758 ! zymosterol from lanosterol: step 5/6 relationship: part_of UPa:UER00758 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 5/6 [Term] id: UPa:UCR07496 name: 4-alpha-methylzymosterol = zymosterol namespace: reaction xref: KEGG:R07496 "KEGG reaction" xref: RHEA:42459 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC05103 ! 4-alpha-methylzymosterol relationship: has_input_compound UPa:UPC05103 {cardinality="1"} ! 4-alpha-methylzymosterol relationship: has_output_compound UPa:UPC05437 {cardinality="1"} ! zymosterol relationship: has_output_compound UPa:UPC05437 ! zymosterol relationship: part_of UPa:UER00759 ! zymosterol from lanosterol: step 6/6 relationship: part_of UPa:UER00759 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 6/6 [Term] id: UPa:UCR07497 name: fecosterol = episterol namespace: reaction xref: KEGG:R07497 "KEGG reaction" xref: METACYC:RXN3O-203 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:33438 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC04525 {cardinality="1"} ! fecosterol relationship: has_input_compound UPa:UPC04525 ! fecosterol relationship: has_output_compound UPa:UPC15777 ! episterol relationship: has_output_compound UPa:UPC15777 {cardinality="1"} ! episterol relationship: part_of UPa:UER00761 {cardinality="1", direction="LR", order="1"} ! ergosterol from zymosterol: step 2/5 relationship: part_of UPa:UER00761 ! ergosterol from zymosterol: step 2/5 [Term] id: UPa:UCR07505 name: NADP(+) + episterol = 5,7,24(28)-ergostatrienol + H(+) + NADPH namespace: reaction xref: KEGG:R07505 "KEGG reaction" xref: RHEA:33466 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC15777 {cardinality="1"} ! episterol relationship: has_input_compound UPa:UPC15777 ! episterol relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC15778 ! 5,7,24(28)-ergostatrienol relationship: has_output_compound UPa:UPC15778 {cardinality="1"} ! 5,7,24(28)-ergostatrienol relationship: part_of UPa:UER00762 ! ergosterol from zymosterol: step 3/5 relationship: part_of UPa:UER00762 {cardinality="1", direction="LR", order="1"} ! ergosterol from zymosterol: step 3/5 [Term] id: UPa:UCR07506 name: 5,7,24(28)-ergostatrienol + NADP(+) = H(+) + NADPH + ergosta-5,7,22,24(28)-tetraen-3beta-ol namespace: reaction xref: KEGG:R07506 "KEGG reaction" xref: METACYC:RXN3O-227 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:33470 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC15778 {cardinality="1"} ! 5,7,24(28)-ergostatrienol relationship: has_input_compound UPa:UPC15778 ! 5,7,24(28)-ergostatrienol relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC05440 {cardinality="1"} ! ergosta-5,7,22,24(28)-tetraen-3beta-ol relationship: has_output_compound UPa:UPC05440 ! ergosta-5,7,22,24(28)-tetraen-3beta-ol relationship: part_of UPa:UER00763 {cardinality="1", direction="LR", order="1"} ! ergosterol from zymosterol: step 4/5 relationship: part_of UPa:UER00763 ! ergosterol from zymosterol: step 4/5 [Term] id: UPa:UCR07509 name: 14-demethyllanosterol + 3 H(+) + 3 NADPH + 3 O(2) = 4alpha-methylzymosterol-4-carboxylic acid + 4 H(2)O + 3 NADP(+) namespace: reaction xref: KEGG:R07509 "KEGG reaction" xref: RHEA:33446 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC05108 ! 14-demethyllanosterol relationship: has_input_compound UPa:UPC05108 {cardinality="1"} ! 14-demethyllanosterol relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC15808 {cardinality="1"} ! 4alpha-methylzymosterol-4-carboxylic acid relationship: has_output_compound UPa:UPC15808 ! 4alpha-methylzymosterol-4-carboxylic acid relationship: part_of UPa:UER00756 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 3/6 relationship: part_of UPa:UER00756 ! zymosterol from lanosterol: step 3/6 [Term] id: UPa:UCR07514 name: 6-hydroxypseudooxynicotine + H(2)O + acceptor = 2,6-dihydroxypseudooxynicotine + reduced acceptor namespace: reaction xref: KEGG:R07514 "KEGG reaction" xref: METACYC:R162-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:34226 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC01297 {cardinality="1"} ! 6-hydroxypseudooxynicotine relationship: has_input_compound UPa:UPC01297 ! 6-hydroxypseudooxynicotine relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC15986 ! 2,6-dihydroxypseudooxynicotine relationship: has_output_compound UPa:UPC15986 {cardinality="1"} ! 2,6-dihydroxypseudooxynicotine relationship: part_of UPa:UER00489 {cardinality="1", direction="LR", order="1"} ! 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine: step 1/2 relationship: part_of UPa:UER00489 ! 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine: step 1/2 [Term] id: UPa:UCR07515 name: 2,6-dihydroxypseudooxynicotine + H(2)O = 2,6-dihydroxypyridine + 4-(methylamino)butanoate namespace: reaction xref: KEGG:R07515 "KEGG reaction" xref: METACYC:R181-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:34170 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC15986 ! 2,6-dihydroxypseudooxynicotine relationship: has_input_compound UPa:UPC15986 {cardinality="1"} ! 2,6-dihydroxypseudooxynicotine relationship: has_output_compound UPa:UPC03056 ! 2,6-dihydroxypyridine relationship: has_output_compound UPa:UPC03056 {cardinality="1"} ! 2,6-dihydroxypyridine relationship: has_output_compound UPa:UPC15987 ! 4-(methylamino)butanoate relationship: has_output_compound UPa:UPC15987 {cardinality="1"} ! 4-(methylamino)butanoate relationship: part_of UPa:UER00490 {cardinality="1", direction="LR", order="1"} ! 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine: step 2/2 relationship: part_of UPa:UER00490 ! 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine: step 2/2 [Term] id: UPa:UCR07613 name: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-tetrahydrodipicolinate + H(2)O + L-glutamate namespace: reaction xref: KEGG:R07613 "KEGG reaction" xref: METACYC:RXN-7737 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23991 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC00666 ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: part_of UPa:UER00466 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1 relationship: part_of UPa:UER00466 {cardinality="1", direction="RL", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1 [Term] id: UPa:UCR07629 name: 3-oxo-3-ureidopropanoic acid + H(2)O = malonate + urea namespace: reaction xref: KEGG:R07629 "KEGG reaction" xref: METACYC:3.5.1.95-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17364 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC15607 {cardinality="1"} ! 3-oxo-3-ureidopropanoic acid relationship: has_input_compound UPa:UPC15607 ! 3-oxo-3-ureidopropanoic acid relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_output_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00383 ! malonate relationship: has_output_compound UPa:UPC00383 {cardinality="1"} ! malonate relationship: part_of UPa:UER00645 {cardinality="1", direction="LR", order="1"} ! malonate and urea from uracil: step 3/3 relationship: part_of UPa:UER00645 ! malonate and urea from uracil: step 3/3 [Term] id: UPa:UCR07647 name: H(2)O + farnesyl diphosphate = diphosphate + germacradienol namespace: reaction xref: KEGG:R07647 "KEGG reaction" xref: METACYC:RXN-8648 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22439 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC16143 ! germacradienol relationship: has_output_compound UPa:UPC16143 {cardinality="1"} ! germacradienol relationship: part_of UPa:UER00583 {cardinality="1", direction="LR", order="1"} ! germacradienol from farnesyl diphosphate: step 1/1 relationship: part_of UPa:UER00583 ! germacradienol from farnesyl diphosphate: step 1/1 [Term] id: UPa:UCR07648 name: farnesyl diphosphate = diphosphate + germacrene D namespace: reaction xref: KEGG:R07648 "KEGG reaction" xref: METACYC:RXN-8562 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12019 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC16142 ! germacrene D relationship: has_output_compound UPa:UPC16142 {cardinality="1"} ! germacrene D relationship: part_of UPa:UER00584 {cardinality="1", direction="LR", order="1"} ! germacrene D from farnesyl diphosphate: step 1/1 relationship: part_of UPa:UER00584 ! germacrene D from farnesyl diphosphate: step 1/1 [Term] id: UPa:UCR07650 name: L-2,4-diaminobutanoate = 1,3-diaminopropane + CO(2) namespace: reaction xref: KEGG:R07650 "KEGG reaction" xref: METACYC:4.1.1.86-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15692 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03283 {cardinality="1"} ! L-2,4-diaminobutanoate relationship: has_input_compound UPa:UPC03283 ! L-2,4-diaminobutanoate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00986 ! 1,3-diaminopropane relationship: has_output_compound UPa:UPC00986 {cardinality="1"} ! 1,3-diaminopropane relationship: part_of UPa:UER00732 ! 1,3-diaminopropane from L-aspartate 4-semialdehyde: step 2/2 relationship: part_of UPa:UER00732 {cardinality="1", direction="LR", order="1"} ! 1,3-diaminopropane from L-aspartate 4-semialdehyde: step 2/2 [Term] id: UPa:UCR07652 name: 2 farnesyl diphosphate = dehydrosqualene + 2 diphosphate namespace: reaction xref: KEGG:R07652 "KEGG reaction" xref: METACYC:RXN-12321 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:31550 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC16144 {cardinality="1"} ! dehydrosqualene relationship: has_output_compound UPa:UPC16144 ! dehydrosqualene relationship: part_of UPa:UER00556 ! staphyloxanthin from farnesyl diphosphate: step 1/5 relationship: part_of UPa:UER00556 {cardinality="1", direction="LR", order="1"} ! staphyloxanthin from farnesyl diphosphate: step 1/5 [Term] id: UPa:UCR07653 name: 3 FAD + dehydrosqualene = 4,4'-diaponeurosporene + 3 FADH2 namespace: reaction xref: KEGG:R07653 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00016 {cardinality="1"} ! FAD relationship: has_input_compound UPa:UPC00016 ! FAD relationship: has_input_compound UPa:UPC16144 {cardinality="1"} ! dehydrosqualene relationship: has_input_compound UPa:UPC16144 ! dehydrosqualene relationship: has_output_compound UPa:UPC01352 ! FADH2 relationship: has_output_compound UPa:UPC01352 {cardinality="1"} ! FADH2 relationship: has_output_compound UPa:UPC16145 {cardinality="1"} ! 4,4'-diaponeurosporene relationship: has_output_compound UPa:UPC16145 ! 4,4'-diaponeurosporene relationship: part_of UPa:UER00557 ! staphyloxanthin from farnesyl diphosphate: step 2/5 relationship: part_of UPa:UER00557 {cardinality="1", direction="LR", order="1"} ! staphyloxanthin from farnesyl diphosphate: step 2/5 [Term] id: UPa:UCR07654 name: 4,4'-diaponeurosporene + 3 O(2) + 3 reduced acceptor = 4,4'-diaponeurosporenic acid + 4 H(2)O + 3 acceptor namespace: reaction xref: KEGG:R07654 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_input_compound UPa:UPC00030 ! reduced acceptor relationship: has_input_compound UPa:UPC16145 {cardinality="1"} ! 4,4'-diaponeurosporene relationship: has_input_compound UPa:UPC16145 ! 4,4'-diaponeurosporene relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00028 ! acceptor relationship: has_output_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_output_compound UPa:UPC16146 {cardinality="1"} ! 4,4'-diaponeurosporenic acid relationship: has_output_compound UPa:UPC16146 ! 4,4'-diaponeurosporenic acid relationship: part_of UPa:UER00558 ! staphyloxanthin from farnesyl diphosphate: step 3/5 relationship: part_of UPa:UER00558 {cardinality="1", direction="LR", order="1"} ! staphyloxanthin from farnesyl diphosphate: step 3/5 [Term] id: UPa:UCR07655 name: 4,4'-diaponeurosporenic acid = glycosyl-4,4'-diaponeurosporenic acid namespace: reaction xref: KEGG:R07655 "KEGG reaction" xref: METACYC:RXN-9308 "MetaCyc REACTION" {source="MetaCyc"} is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC16146 {cardinality="1"} ! 4,4'-diaponeurosporenic acid relationship: has_input_compound UPa:UPC16146 ! 4,4'-diaponeurosporenic acid relationship: has_output_compound UPa:UPC16147 {cardinality="1"} ! glycosyl-4,4'-diaponeurosporenic acid relationship: has_output_compound UPa:UPC16147 ! glycosyl-4,4'-diaponeurosporenic acid relationship: part_of UPa:UER00559 ! staphyloxanthin from farnesyl diphosphate: step 4/5 relationship: part_of UPa:UER00559 {cardinality="1", direction="LR", order="1"} ! staphyloxanthin from farnesyl diphosphate: step 4/5 [Term] id: UPa:UCR07656 name: glycosyl-4,4'-diaponeurosporenic acid = staphyloxanthin namespace: reaction xref: KEGG:R07656 "KEGG reaction" xref: METACYC:RXN-9309 "MetaCyc REACTION" {source="MetaCyc"} is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC16147 {cardinality="1"} ! glycosyl-4,4'-diaponeurosporenic acid relationship: has_input_compound UPa:UPC16147 ! glycosyl-4,4'-diaponeurosporenic acid relationship: has_output_compound UPa:UPC16148 {cardinality="1"} ! staphyloxanthin relationship: has_output_compound UPa:UPC16148 ! staphyloxanthin relationship: part_of UPa:UER00560 ! staphyloxanthin from farnesyl diphosphate: step 5/5 relationship: part_of UPa:UER00560 {cardinality="1", direction="LR", order="1"} ! staphyloxanthin from farnesyl diphosphate: step 5/5 [Term] id: UPa:UCR07658 name: NAD(+) + UDP-alpha-D-glucuronate = CO(2) + H(+) + NADH + UDP-beta-L-threo-pentopyranos-4-ulose namespace: reaction xref: KEGG:R07658 "KEGG reaction" xref: METACYC:RXN0-1861 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24705 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate relationship: has_input_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC16155 {cardinality="1"} ! UDP-beta-L-threo-pentopyranos-4-ulose relationship: has_output_compound UPa:UPC16155 ! UDP-beta-L-threo-pentopyranos-4-ulose relationship: part_of UPa:UER00492 {cardinality="1", direction="LR", order="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 1/3 relationship: part_of UPa:UER00492 ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 1/3 [Term] id: UPa:UCR07659 name: L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose = 2-oxoglutarate + UDP-4-amino-4-deoxy-L-arabinose namespace: reaction xref: KEGG:R07659 "KEGG reaction" xref: METACYC:RXN0-1863 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24713 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC16155 {cardinality="1"} ! UDP-beta-L-threo-pentopyranos-4-ulose relationship: has_input_compound UPa:UPC16155 ! UDP-beta-L-threo-pentopyranos-4-ulose relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC16153 {cardinality="1"} ! UDP-4-amino-4-deoxy-L-arabinose relationship: has_output_compound UPa:UPC16153 ! UDP-4-amino-4-deoxy-L-arabinose relationship: part_of UPa:UER00493 {cardinality="1", direction="LR", order="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 2/3 relationship: part_of UPa:UER00493 ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 2/3 [Term] id: UPa:UCR07660 name: 10-formyl-5,6,7,8-tetrahydrofolate + UDP-4-amino-4-deoxy-L-arabinose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinose namespace: reaction xref: KEGG:R07660 "KEGG reaction" xref: METACYC:RXN0-1862 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24709 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00234 {cardinality="1"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00234 ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC16153 ! UDP-4-amino-4-deoxy-L-arabinose relationship: has_input_compound UPa:UPC16153 {cardinality="1"} ! UDP-4-amino-4-deoxy-L-arabinose relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC16154 ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: has_output_compound UPa:UPC16154 {cardinality="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: part_of UPa:UER00494 ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 3/3 relationship: part_of UPa:UER00494 {cardinality="1", direction="LR", order="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 3/3 [Term] id: UPa:UCR07661 name: UDP-4-deoxy-4-formamido-beta-L-arabinose + di-trans,poly-cis-undecaprenyl phosphate = 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate + UDP namespace: reaction xref: KEGG:R07661 "KEGG reaction" xref: METACYC:RXN0-3521 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26360 "Rhea reaction" xref: RHEA:27725 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC16154 ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: has_input_compound UPa:UPC16154 {cardinality="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: has_input_compound UPa:UPC17556 {cardinality="1"} ! di-trans,poly-cis-undecaprenyl phosphate relationship: has_input_compound UPa:UPC17556 ! di-trans,poly-cis-undecaprenyl phosphate relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC16156 ! 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate relationship: has_output_compound UPa:UPC16156 {cardinality="1"} ! 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate relationship: part_of UPa:UER00495 ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 1/2 relationship: part_of UPa:UER00495 {cardinality="1", direction="LR", order="1"} ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 1/2 [Term] id: UPa:UCR07662 name: 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate + H(2)O = 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate + formate namespace: reaction xref: KEGG:R07662 "KEGG reaction" xref: METACYC:RXN0-5409 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:27737 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC16156 {cardinality="1"} ! 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate relationship: has_input_compound UPa:UPC16156 ! 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC16157 ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate relationship: has_output_compound UPa:UPC16157 {cardinality="1"} ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate relationship: part_of UPa:UER00496 ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2 relationship: part_of UPa:UER00496 {cardinality="1", direction="LR", order="1"} ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2 [Term] id: UPa:UCR07671 name: L-ascorbate + protein N(pi)-phospho-L-histidine = L-ascorbate 6-phosphate + protein-L-histidine namespace: reaction xref: KEGG:R07671 "KEGG reaction" xref: RHEA:42439 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_input_compound UPa:UPC00072 ! L-ascorbate relationship: has_input_compound UPa:UPC04261 {cardinality="1"} ! protein N(pi)-phospho-L-histidine relationship: has_input_compound UPa:UPC04261 ! protein N(pi)-phospho-L-histidine relationship: has_output_compound UPa:UPC00615 ! protein-L-histidine relationship: has_output_compound UPa:UPC00615 {cardinality="1"} ! protein-L-histidine relationship: has_output_compound UPa:UPC16186 {cardinality="1"} ! L-ascorbate 6-phosphate relationship: has_output_compound UPa:UPC16186 ! L-ascorbate 6-phosphate relationship: part_of UPa:UER00377 ! D-xylulose 5-phosphate from L-ascorbate: step 1/4 relationship: part_of UPa:UER00377 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-ascorbate: step 1/4 [Term] id: UPa:UCR07672 name: GDP-alpha-D-mannose = GDP-L-gulose namespace: reaction xref: KEGG:R07672 "KEGG reaction" xref: METACYC:RXN-7771 "MetaCyc REACTION" {source="MetaCyc"} is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC15925 ! GDP-L-gulose relationship: has_output_compound UPa:UPC15925 {cardinality="1"} ! GDP-L-gulose relationship: part_of UPa:UER00931 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from GDP-alpha-D-mannose: step 1/5 relationship: part_of UPa:UER00931 ! L-ascorbate from GDP-alpha-D-mannose: step 1/5 [Term] id: UPa:UCR07673 name: GDP-L-gulose = GDP-L-galactose namespace: reaction xref: KEGG:R07673 "KEGG reaction" xref: METACYC:RXN-7772 "MetaCyc REACTION" {source="MetaCyc"} is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC15925 ! GDP-L-gulose relationship: has_input_compound UPa:UPC15925 {cardinality="1"} ! GDP-L-gulose relationship: has_output_compound UPa:UPC02280 ! GDP-L-galactose relationship: has_output_compound UPa:UPC02280 {cardinality="1"} ! GDP-L-galactose relationship: part_of UPa:UER00931 {cardinality="1", direction="LR", order="2"} ! L-ascorbate from GDP-alpha-D-mannose: step 1/5 relationship: part_of UPa:UER00931 ! L-ascorbate from GDP-alpha-D-mannose: step 1/5 [Term] id: UPa:UCR07674 name: H(2)O + beta-L-galactose 1-phosphate = alpha-L-galactose + phosphate namespace: reaction xref: KEGG:R07674 "KEGG reaction" xref: METACYC:RXNQT-4142 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26352 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC15926 ! beta-L-galactose 1-phosphate relationship: has_input_compound UPa:UPC15926 {cardinality="1"} ! beta-L-galactose 1-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC01825 {cardinality="1"} ! alpha-L-galactose relationship: has_output_compound UPa:UPC01825 ! alpha-L-galactose relationship: part_of UPa:UER00933 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from GDP-alpha-D-mannose: step 3/5 relationship: part_of UPa:UER00933 ! L-ascorbate from GDP-alpha-D-mannose: step 3/5 [Term] id: UPa:UCR07675 name: NAD(+) + alpha-L-galactose = H(+) + L-Galactono-1,4-lactone + NADH namespace: reaction xref: KEGG:R07675 "KEGG reaction" xref: METACYC:RXN-1884 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:31562 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC01825 ! alpha-L-galactose relationship: has_input_compound UPa:UPC01825 {cardinality="1"} ! alpha-L-galactose relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01115 ! L-Galactono-1,4-lactone relationship: has_output_compound UPa:UPC01115 {cardinality="1"} ! L-Galactono-1,4-lactone relationship: part_of UPa:UER00934 ! L-ascorbate from GDP-alpha-D-mannose: step 4/5 relationship: part_of UPa:UER00934 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from GDP-alpha-D-mannose: step 4/5 [Term] id: UPa:UCR07677 name: H(2)O + L-ascorbate 6-phosphate = 3-dehydro-L-gulonate 6-phosphate namespace: reaction xref: KEGG:R07677 "KEGG reaction" xref: METACYC:RXN0-5214 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28806 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC16186 {cardinality="1"} ! L-ascorbate 6-phosphate relationship: has_input_compound UPa:UPC16186 ! L-ascorbate 6-phosphate relationship: has_output_compound UPa:UPC14899 {cardinality="1"} ! 3-dehydro-L-gulonate 6-phosphate relationship: has_output_compound UPa:UPC14899 ! 3-dehydro-L-gulonate 6-phosphate relationship: part_of UPa:UER00377 ! D-xylulose 5-phosphate from L-ascorbate: step 1/4 relationship: part_of UPa:UER00377 {cardinality="1", direction="LR", order="2"} ! D-xylulose 5-phosphate from L-ascorbate: step 1/4 [Term] id: UPa:UCR07678 name: GDP-L-galactose + phosphate = GDP + beta-L-galactose 1-phosphate namespace: reaction xref: KEGG:R07678 "KEGG reaction" xref: RHEA:27701 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC02280 ! GDP-L-galactose relationship: has_input_compound UPa:UPC02280 {cardinality="1"} ! GDP-L-galactose relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_output_compound UPa:UPC00035 ! GDP relationship: has_output_compound UPa:UPC15926 ! beta-L-galactose 1-phosphate relationship: has_output_compound UPa:UPC15926 {cardinality="1"} ! beta-L-galactose 1-phosphate relationship: part_of UPa:UER00932 ! L-ascorbate from GDP-alpha-D-mannose: step 2/5 relationship: part_of UPa:UER00932 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from GDP-alpha-D-mannose: step 2/5 [Term] id: UPa:UCR07766 name: apoprotein + octanoyl-[acyl-carrier-protein] = acyl-carrier protein + protein N(6)-(octanoyl)lysine namespace: reaction xref: KEGG:R07766 "KEGG reaction" xref: RHEA:17668 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC05752 ! octanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC05752 {cardinality="1"} ! octanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC16240 {cardinality="1"} ! apoprotein relationship: has_input_compound UPa:UPC16240 ! apoprotein relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC16236 {cardinality="1"} ! protein N(6)-(octanoyl)lysine relationship: has_output_compound UPa:UPC16236 ! protein N(6)-(octanoyl)lysine relationship: part_of UPa:UER00592 {cardinality="1", direction="LR", order="1"} ! protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2 relationship: part_of UPa:UER00592 ! protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2 [Term] id: UPa:UCR07767 name: 2 S-adenosyl-L-methionine + protein N(6)-(octanoyl)lysine + 2 sulfur donor = 2 5'-deoxyadenosine + 2 L-methionine + protein N(6)-(lipoyl)lysine namespace: reaction xref: KEGG:R07767 "KEGG reaction" xref: RHEA:16588 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC16236 {cardinality="1"} ! protein N(6)-(octanoyl)lysine relationship: has_input_compound UPa:UPC16236 ! protein N(6)-(octanoyl)lysine relationship: has_input_compound UPa:UPC17023 {cardinality="1"} ! sulfur donor relationship: has_input_compound UPa:UPC17023 ! sulfur donor relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC05198 {cardinality="1"} ! 5'-deoxyadenosine relationship: has_output_compound UPa:UPC05198 ! 5'-deoxyadenosine relationship: has_output_compound UPa:UPC16237 {cardinality="1"} ! protein N(6)-(lipoyl)lysine relationship: has_output_compound UPa:UPC16237 ! protein N(6)-(lipoyl)lysine relationship: part_of UPa:UER00593 {cardinality="1", direction="LR", order="1"} ! protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2 relationship: part_of UPa:UER00593 ! protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2 [Term] id: UPa:UCR07770 name: ATP + lipoate = diphosphate + lipoyl-AMP namespace: reaction xref: KEGG:R07770 "KEGG reaction" xref: METACYC:RXN-8654 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12916 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00725 ! lipoate relationship: has_input_compound UPa:UPC00725 {cardinality="1"} ! lipoate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC16238 ! lipoyl-AMP relationship: has_output_compound UPa:UPC16238 {cardinality="1"} ! lipoyl-AMP relationship: part_of UPa:UER00594 ! protein N(6)-(lipoyl)lysine from lipoate: step 1/2 relationship: part_of UPa:UER00594 {cardinality="1", direction="LR", order="1"} ! protein N(6)-(lipoyl)lysine from lipoate: step 1/2 [Term] id: UPa:UCR07771 name: apoprotein + lipoyl-AMP = AMP + protein N(6)-(lipoyl)lysine namespace: reaction xref: KEGG:R07771 "KEGG reaction" xref: METACYC:RXN-8655 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20476 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC16238 ! lipoyl-AMP relationship: has_input_compound UPa:UPC16238 {cardinality="1"} ! lipoyl-AMP relationship: has_input_compound UPa:UPC16240 ! apoprotein relationship: has_input_compound UPa:UPC16240 {cardinality="1"} ! apoprotein relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC16237 ! protein N(6)-(lipoyl)lysine relationship: has_output_compound UPa:UPC16237 {cardinality="1"} ! protein N(6)-(lipoyl)lysine relationship: part_of UPa:UER00595 ! protein N(6)-(lipoyl)lysine from lipoate: step 2/2 relationship: part_of UPa:UER00595 {cardinality="1", direction="LR", order="1"} ! protein N(6)-(lipoyl)lysine from lipoate: step 2/2 [Term] id: UPa:UCR07772 name: H(2)O + cobalt-precorrin 5A = acetaldehyde + cobalt-precorrin 5B namespace: reaction xref: KEGG:R07772 "KEGG reaction" xref: METACYC:RXN-8763 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26284 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC16242 ! cobalt-precorrin 5A relationship: has_input_compound UPa:UPC16242 {cardinality="1"} ! cobalt-precorrin 5A relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC16243 ! cobalt-precorrin 5B relationship: has_output_compound UPa:UPC16243 {cardinality="1"} ! cobalt-precorrin 5B relationship: part_of UPa:UER00561 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 5/10 relationship: part_of UPa:UER00561 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 5/10 [Term] id: UPa:UCR07773 name: S-adenosyl-L-methionine + cobalt-precorrin 5B = S-adenosyl-L-homocysteine + cobalt-precorrin-6A namespace: reaction xref: KEGG:R07773 "KEGG reaction" xref: METACYC:RXN-8764 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26288 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC16243 {cardinality="1"} ! cobalt-precorrin 5B relationship: has_input_compound UPa:UPC16243 ! cobalt-precorrin 5B relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11542 ! cobalt-precorrin-6A relationship: has_output_compound UPa:UPC11542 {cardinality="1"} ! cobalt-precorrin-6A relationship: part_of UPa:UER00227 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10 relationship: part_of UPa:UER00227 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10 [Term] id: UPa:UCR07916 name: 2 geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate namespace: reaction xref: KEGG:R07916 "KEGG reaction" xref: METACYC:RXN1F-144 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:32454 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate relationship: has_input_compound UPa:UPC00353 ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC05413 {cardinality="1"} ! all-trans-phytoene relationship: has_output_compound UPa:UPC05413 ! all-trans-phytoene relationship: part_of UPa:UER00773 {cardinality="1", direction="LR", order="1"} ! all-trans-phytoene from geranylgeranyl diphosphate: step 1/1 relationship: part_of UPa:UER00773 ! all-trans-phytoene from geranylgeranyl diphosphate: step 1/1 [Term] id: UPa:UCR07946 name: H(2)O + acceptor + nicotine = (R)-6-hydroxynicotine + reduced acceptor namespace: reaction xref: KEGG:R07946 "KEGG reaction" xref: METACYC:R161-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42355 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC16150 ! nicotine relationship: has_input_compound UPa:UPC16150 {cardinality="1"} ! nicotine relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC03043 ! (R)-6-hydroxynicotine relationship: has_output_compound UPa:UPC03043 {cardinality="1"} ! (R)-6-hydroxynicotine relationship: part_of UPa:UER00918 {cardinality="1", direction="LR", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (R-isomer route): step 1/2 relationship: part_of UPa:UER00918 ! 6-hydroxypseudooxynicotine from nicotine (R-isomer route): step 1/2 [Term] id: UPa:UCR07984 name: 6-hydroxynicotinate + 2 H(2)O = 2-formylglutarate + NH(3) namespace: reaction xref: KEGG:R07984 "KEGG reaction" xref: METACYC:3.5.2.18-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17212 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04226 {cardinality="1"} ! 6-hydroxynicotinate relationship: has_input_compound UPa:UPC04226 ! 6-hydroxynicotinate relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC16159 ! 2-formylglutarate relationship: has_output_compound UPa:UPC16159 {cardinality="1"} ! 2-formylglutarate relationship: part_of UPa:UER01013 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 2/8 relationship: part_of UPa:UER01013 ! propanoate and pyruvate from 6-hydroxynicotinate: step 2/8 [Term] id: UPa:UCR07985 name: 2-formylglutarate + H(+) + NADH = 2-hydroxymethylglutarate + NAD(+) namespace: reaction xref: KEGG:R07985 "KEGG reaction" xref: METACYC:1.1.1.291-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15508 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC16159 ! 2-formylglutarate relationship: has_input_compound UPa:UPC16159 {cardinality="1"} ! 2-formylglutarate relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC16390 ! 2-hydroxymethylglutarate relationship: has_output_compound UPa:UPC16390 {cardinality="1"} ! 2-hydroxymethylglutarate relationship: part_of UPa:UER01014 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 3/8 relationship: part_of UPa:UER01014 ! propanoate and pyruvate from 6-hydroxynicotinate: step 3/8 [Term] id: UPa:UCR07986 name: 2-hydroxymethylglutarate = 2-methyleneglutarate + H(2)O namespace: reaction xref: KEGG:R07986 "KEGG reaction" xref: METACYC:RXN-7640 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:27585 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC16390 ! 2-hydroxymethylglutarate relationship: has_input_compound UPa:UPC16390 {cardinality="1"} ! 2-hydroxymethylglutarate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC02930 {cardinality="1"} ! 2-methyleneglutarate relationship: has_output_compound UPa:UPC02930 ! 2-methyleneglutarate relationship: part_of UPa:UER01015 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 4/8 relationship: part_of UPa:UER01015 ! propanoate and pyruvate from 6-hydroxynicotinate: step 4/8 [Term] id: UPa:UCR08058 name: 5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylene-5,6,7,8-tetrahydromethanopterin + H(2)O namespace: reaction xref: KEGG:R08058 "KEGG reaction" xref: METACYC:RXN-2882 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24681 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_input_compound UPa:UPC00067 ! formaldehyde relationship: has_input_compound UPa:UPC01217 {cardinality="1"} ! 5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC01217 ! 5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00701 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (H(4)MPT route): step 1/5 relationship: part_of UPa:UER00701 ! formate from formaldehyde (H(4)MPT route): step 1/5 [Term] id: UPa:UCR08059 name: 5,10-methylene-5,6,7,8-tetrahydromethanopterin + NADP(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH namespace: reaction xref: KEGG:R08059 "KEGG reaction" xref: METACYC:RXN-2883 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24685 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00702 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (H(4)MPT route): step 2/5 relationship: part_of UPa:UER00702 ! formate from formaldehyde (H(4)MPT route): step 2/5 [Term] id: UPa:UCR08060 name: H(2)O + N-formylmethanofuran = formate + methanofuran namespace: reaction xref: KEGG:R08060 "KEGG reaction" xref: METACYC:RXN-14028 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24689 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01001 ! N-formylmethanofuran relationship: has_input_compound UPa:UPC01001 {cardinality="1"} ! N-formylmethanofuran relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00862 ! methanofuran relationship: has_output_compound UPa:UPC00862 {cardinality="1"} ! methanofuran relationship: part_of UPa:UER00705 ! formate from formaldehyde (H(4)MPT route): step 5/5 relationship: part_of UPa:UER00705 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (H(4)MPT route): step 5/5 [Term] id: UPa:UCR08124 name: ATP + fructoselysine = ADP + fructoselysine 6-phosphate namespace: reaction xref: KEGG:R08124 "KEGG reaction" xref: METACYC:RXN0-962 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28381 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC16488 {cardinality="1"} ! fructoselysine relationship: has_input_compound UPa:UPC16488 ! fructoselysine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC16489 ! fructoselysine 6-phosphate relationship: has_output_compound UPa:UPC16489 {cardinality="1"} ! fructoselysine 6-phosphate relationship: part_of UPa:UER00769 {cardinality="1", direction="LR", order="1"} ! D-glucose 6-phosphate and lysine from fructoselysine: step 1/2 relationship: part_of UPa:UER00769 ! D-glucose 6-phosphate and lysine from fructoselysine: step 1/2 [Term] id: UPa:UCR08125 name: H(2)O + fructoselysine 6-phosphate = D-glucose 6-phosphate + L-lysine namespace: reaction xref: KEGG:R08125 "KEGG reaction" xref: METACYC:RXN0-963 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:28385 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC16489 ! fructoselysine 6-phosphate relationship: has_input_compound UPa:UPC16489 {cardinality="1"} ! fructoselysine 6-phosphate relationship: has_output_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_output_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: part_of UPa:UER00770 ! D-glucose 6-phosphate and lysine from fructoselysine: step 2/2 relationship: part_of UPa:UER00770 {cardinality="1", direction="LR", order="1"} ! D-glucose 6-phosphate and lysine from fructoselysine: step 2/2 [Term] id: UPa:UCR08165 name: 2-oxoglutarate + isochorismate = 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid + CO(2) namespace: reaction xref: KEGG:R08165 "KEGG reaction" xref: METACYC:2.5.1.64-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25596 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00885 ! isochorismate relationship: has_input_compound UPa:UPC00885 {cardinality="1"} ! isochorismate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC16519 ! 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid relationship: has_output_compound UPa:UPC16519 {cardinality="1"} ! 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid relationship: part_of UPa:UER00164 ! 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7 relationship: part_of UPa:UER00164 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7 [Term] id: UPa:UCR08166 name: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid + pyruvate namespace: reaction xref: KEGG:R08166 "KEGG reaction" xref: METACYC:RXN-9310 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25600 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC16519 ! 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid relationship: has_input_compound UPa:UPC16519 {cardinality="1"} ! 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC05817 {cardinality="1"} ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid relationship: has_output_compound UPa:UPC05817 ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid relationship: part_of UPa:UER00900 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 3/7 relationship: part_of UPa:UER00900 ! 1,4-dihydroxy-2-naphthoate from chorismate: step 3/7 [Term] id: UPa:UCR08171 name: N-(3'R)-debenzoyltaxol + benzoyl-CoA = CoA + taxol namespace: reaction xref: KEGG:R08171 "KEGG reaction" xref: METACYC:RXN-8859 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:33690 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00512 ! benzoyl-CoA relationship: has_input_compound UPa:UPC00512 {cardinality="1"} ! benzoyl-CoA relationship: has_input_compound UPa:UPC16524 {cardinality="1"} ! N-(3'R)-debenzoyltaxol relationship: has_input_compound UPa:UPC16524 ! N-(3'R)-debenzoyltaxol relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC07394 ! taxol relationship: has_output_compound UPa:UPC07394 {cardinality="1"} ! taxol relationship: part_of UPa:UER00053 ! taxol from baccatin III: step 3/3 relationship: part_of UPa:UER00053 {cardinality="1", direction="LR", order="1"} ! taxol from baccatin III: step 3/3 [Term] id: UPa:UCR08172 name: baccatin III + beta-phenylalanoyl-CoA = CoA + N-(3'R)-debenzoyl-2'-deoxytaxol namespace: reaction xref: KEGG:R08172 "KEGG reaction" xref: METACYC:RXN-8857 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42491 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC11900 ! baccatin III relationship: has_input_compound UPa:UPC11900 {cardinality="1"} ! baccatin III relationship: has_input_compound UPa:UPC16833 ! beta-phenylalanoyl-CoA relationship: has_input_compound UPa:UPC16833 {cardinality="1"} ! beta-phenylalanoyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC16523 {cardinality="1"} ! N-(3'R)-debenzoyl-2'-deoxytaxol relationship: has_output_compound UPa:UPC16523 ! N-(3'R)-debenzoyl-2'-deoxytaxol relationship: part_of UPa:UER00812 ! taxol from baccatin III: step 1/3 relationship: part_of UPa:UER00812 {cardinality="1", direction="LR", order="1"} ! taxol from baccatin III: step 1/3 [Term] id: UPa:UCR08173 name: N-(3'R)-debenzoyl-2'-deoxytaxol + O(2) + reduced acceptor = H(2)O + N-(3'R)-debenzoyltaxol + acceptor namespace: reaction xref: KEGG:R08173 "KEGG reaction" xref: RHEA:42495 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00030 ! reduced acceptor relationship: has_input_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_input_compound UPa:UPC16523 {cardinality="1"} ! N-(3'R)-debenzoyl-2'-deoxytaxol relationship: has_input_compound UPa:UPC16523 ! N-(3'R)-debenzoyl-2'-deoxytaxol relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00028 ! acceptor relationship: has_output_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_output_compound UPa:UPC16524 {cardinality="1"} ! N-(3'R)-debenzoyltaxol relationship: has_output_compound UPa:UPC16524 ! N-(3'R)-debenzoyltaxol relationship: part_of UPa:UER00813 {cardinality="1", direction="LR", order="1"} ! taxol from baccatin III: step 2/3 relationship: part_of UPa:UER00813 ! taxol from baccatin III: step 2/3 [Term] id: UPa:UCR08193 name: N-acetyl-D-glucosamine 6-phosphate = N-acetyl-alpha-D-glucosamine 1-phosphate namespace: reaction xref: KEGG:R08193 "KEGG reaction" xref: METACYC:PHOSACETYLGLUCOSAMINEMUT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23807 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00357 ! N-acetyl-D-glucosamine 6-phosphate relationship: has_input_compound UPa:UPC00357 {cardinality="1"} ! N-acetyl-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC04501 {cardinality="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC04501 ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: part_of UPa:UER00530 {cardinality="1", direction="LR", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2 relationship: part_of UPa:UER00530 ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2 [Term] id: UPa:UCR08211 name: H(2)O + O(2) + betaine aldehyde = H(2)O(2) + betaine namespace: reaction xref: KEGG:R08211 "KEGG reaction" xref: RHEA:20372 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: has_input_compound UPa:UPC00576 ! betaine aldehyde relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00719 {cardinality="1"} ! betaine relationship: has_output_compound UPa:UPC00719 ! betaine relationship: part_of UPa:UER00384 ! betaine from choline: step 1/1 relationship: part_of UPa:UER00384 {cardinality="1", direction="LR", order="2"} ! betaine from choline: step 1/1 [Term] id: UPa:UCR08218 name: ATP + L-serine + tRNA(Sec) = AMP + L-seryl-tRNA(Sec) + diphosphate namespace: reaction xref: KEGG:R08218 "KEGG reaction" xref: METACYC:RXN0-2161 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42583 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC16636 ! tRNA(Sec) relationship: has_input_compound UPa:UPC16636 {cardinality="1"} ! tRNA(Sec) relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC06481 ! L-seryl-tRNA(Sec) relationship: has_output_compound UPa:UPC06481 {cardinality="1"} ! L-seryl-tRNA(Sec) relationship: part_of UPa:UER00895 {cardinality="1", direction="LR", order="1"} ! L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1 relationship: part_of UPa:UER00895 ! L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1 [Term] id: UPa:UCR08219 name: L-seryl-tRNA(Sec) + selenophosphate = phosphate + selenocysteinyl-tRNA(Sec) namespace: reaction xref: KEGG:R08219 "KEGG reaction" xref: METACYC:2.9.1.1-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22731 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC05172 {cardinality="1"} ! selenophosphate relationship: has_input_compound UPa:UPC05172 ! selenophosphate relationship: has_input_compound UPa:UPC06481 ! L-seryl-tRNA(Sec) relationship: has_input_compound UPa:UPC06481 {cardinality="1"} ! L-seryl-tRNA(Sec) relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC06482 ! selenocysteinyl-tRNA(Sec) relationship: has_output_compound UPa:UPC06482 {cardinality="1"} ! selenocysteinyl-tRNA(Sec) relationship: part_of UPa:UER00896 {cardinality="1", direction="LR", order="1"} ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1 relationship: part_of UPa:UER00896 ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1 [Term] id: UPa:UCR08223 name: ATP + L-seryl-tRNA(Sec) = ADP + O-phosphoseryl-tRNA(Sec) namespace: reaction xref: KEGG:R08223 "KEGG reaction" xref: METACYC:RXN-10038 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:25040 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC06481 ! L-seryl-tRNA(Sec) relationship: has_input_compound UPa:UPC06481 {cardinality="1"} ! L-seryl-tRNA(Sec) relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC16638 ! O-phosphoseryl-tRNA(Sec) relationship: has_output_compound UPa:UPC16638 {cardinality="1"} ! O-phosphoseryl-tRNA(Sec) relationship: part_of UPa:UER00897 ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 1/2 relationship: part_of UPa:UER00897 {cardinality="1", direction="LR", order="1"} ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 1/2 [Term] id: UPa:UCR08224 name: H(2)O + O-phosphoseryl-tRNA(Sec) + selenophosphate = 2 phosphate + selenocysteinyl-tRNA(Sec) namespace: reaction xref: KEGG:R08224 "KEGG reaction" xref: RHEA:25044 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC05172 {cardinality="1"} ! selenophosphate relationship: has_input_compound UPa:UPC05172 ! selenophosphate relationship: has_input_compound UPa:UPC16638 ! O-phosphoseryl-tRNA(Sec) relationship: has_input_compound UPa:UPC16638 {cardinality="1"} ! O-phosphoseryl-tRNA(Sec) relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC06482 ! selenocysteinyl-tRNA(Sec) relationship: has_output_compound UPa:UPC06482 {cardinality="1"} ! selenocysteinyl-tRNA(Sec) relationship: part_of UPa:UER00898 ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2 relationship: part_of UPa:UER00898 {cardinality="1", direction="LR", order="1"} ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2 [Term] id: UPa:UCR08247 name: beta-D-ribopyranose = beta-D-ribofuranose namespace: reaction xref: KEGG:R08247 "KEGG reaction" xref: METACYC:RXN0-5304 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25435 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC08353 {cardinality="1"} ! beta-D-ribopyranose relationship: has_input_compound UPa:UPC08353 ! beta-D-ribopyranose relationship: has_output_compound UPa:UPC16639 ! beta-D-ribofuranose relationship: has_output_compound UPa:UPC16639 {cardinality="1"} ! beta-D-ribofuranose relationship: part_of UPa:UER00888 ! D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2 relationship: part_of UPa:UER00888 {cardinality="1", direction="LR", order="1"} ! D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2 [Term] id: UPa:UCR08503 name: 5-deoxy-D-glucuronic acid = 2-deoxy-5-keto-D-gluconic acid namespace: reaction xref: KEGG:R08503 "KEGG reaction" xref: METACYC:RXN-14150 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:25843 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC16737 {cardinality="1"} ! 5-deoxy-D-glucuronic acid relationship: has_input_compound UPa:UPC16737 ! 5-deoxy-D-glucuronic acid relationship: has_output_compound UPa:UPC06892 {cardinality="1"} ! 2-deoxy-5-keto-D-gluconic acid relationship: has_output_compound UPa:UPC06892 ! 2-deoxy-5-keto-D-gluconic acid relationship: part_of UPa:UER00920 ! acetyl-CoA from myo-inositol: step 4/7 relationship: part_of UPa:UER00920 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 4/7 [Term] id: UPa:UCR08549 name: 2-oxoglutarate + CoA + NAD(+) = CO(2) + H(+) + NADH + succinyl-CoA namespace: reaction xref: KEGG:R08549 "KEGG reaction" xref: METACYC:2OXOGLUTARATEDEH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:27789 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: part_of UPa:UER00997 ! succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1 relationship: part_of UPa:UER00997 {cardinality="1", direction="LR", order="1"} ! succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1 [Term] id: UPa:UCR08557 name: NAD(+) + choline = H(+) + NADH + betaine aldehyde namespace: reaction xref: KEGG:R08557 "KEGG reaction" xref: METACYC:RXN-6021 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:33054 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: part_of UPa:UER00587 {cardinality="1", direction="LR", order="1"} ! betaine aldehyde from choline (dehydrogenase route): step 1/1 relationship: part_of UPa:UER00587 ! betaine aldehyde from choline (dehydrogenase route): step 1/1 [Term] id: UPa:UCR08574 name: CTP + riboflavin = CDP + FMN namespace: reaction xref: KEGG:R08574 "KEGG reaction" xref: METACYC:RXN-9296 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25024 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00255 ! riboflavin relationship: has_input_compound UPa:UPC00255 {cardinality="1"} ! riboflavin relationship: has_output_compound UPa:UPC00061 {cardinality="1"} ! FMN relationship: has_output_compound UPa:UPC00061 ! FMN relationship: has_output_compound UPa:UPC00112 ! CDP relationship: has_output_compound UPa:UPC00112 {cardinality="1"} ! CDP relationship: part_of UPa:UER00929 {cardinality="1", direction="LR", order="1"} ! FMN from riboflavin (CTP route): step 1/1 relationship: part_of UPa:UER00929 ! FMN from riboflavin (CTP route): step 1/1 [Term] id: UPa:UCR08603 name: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O = 5-deoxy-D-glucuronic acid namespace: reaction xref: KEGG:R08603 "KEGG reaction" xref: RHEA:25839 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04287 {cardinality="1"} ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione relationship: has_input_compound UPa:UPC04287 ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione relationship: has_output_compound UPa:UPC16737 ! 5-deoxy-D-glucuronic acid relationship: has_output_compound UPa:UPC16737 {cardinality="1"} ! 5-deoxy-D-glucuronic acid relationship: part_of UPa:UER00145 ! acetyl-CoA from myo-inositol: step 3/7 relationship: part_of UPa:UER00145 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 3/7 [Term] id: UPa:UCR08615 name: H(2)O + UDP-alpha-D-glucuronate = D-glucuronate + UDP namespace: reaction xref: KEGG:R08615 "KEGG reaction" xref: RHEA:26076 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate relationship: has_input_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC00191 ! D-glucuronate relationship: has_output_compound UPa:UPC00191 {cardinality="1"} ! D-glucuronate relationship: part_of UPa:UER00936 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 1/4 relationship: part_of UPa:UER00936 ! L-ascorbate from UDP-alpha-D-glucuronate: step 1/4 [Term] id: UPa:UCR08617 name: D-glucose 6-phosphate = 2-deoxy-scyllo-inosose + phosphate namespace: reaction xref: KEGG:R08617 "KEGG reaction" xref: RHEA:33074 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC17209 ! 2-deoxy-scyllo-inosose relationship: has_output_compound UPa:UPC17209 {cardinality="1"} ! 2-deoxy-scyllo-inosose relationship: part_of UPa:UER00921 {cardinality="1", direction="LR", order="1"} ! 2-deoxystreptamine from D-glucose 6-phosphate: step 1/4 relationship: part_of UPa:UER00921 ! 2-deoxystreptamine from D-glucose 6-phosphate: step 1/4 [Term] id: UPa:UCR08656 name: 2 H(+) + L-tyrosine + 2 NADPH + 2 O(2) = (Z)-(4-hydroxyphenyl)acetaldehyde oxime + CO(2) + 3 H(2)O + 2 NADP(+) namespace: reaction xref: KEGG:R08656 "KEGG reaction" xref: RHEA:32314 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: has_input_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC04353 {cardinality="1"} ! (Z)-(4-hydroxyphenyl)acetaldehyde oxime relationship: has_output_compound UPa:UPC04353 ! (Z)-(4-hydroxyphenyl)acetaldehyde oxime relationship: part_of UPa:UER00744 ! dhurrin from L-tyrosine: step 1/3 relationship: part_of UPa:UER00744 {cardinality="1", direction="LR", order="1"} ! dhurrin from L-tyrosine: step 1/3 [Term] id: UPa:UCR08689 name: 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + 2 reduced ferredoxin = (2E)-4-hydroxy-3-methylbutenyl diphosphate + H(2)O + 2 oxidized ferredoxin namespace: reaction xref: KEGG:R08689 "KEGG reaction" xref: METACYC:RXN0-882 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26122 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00138 ! reduced ferredoxin relationship: has_input_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin relationship: has_input_compound UPa:UPC11453 {cardinality="1"} ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate relationship: has_input_compound UPa:UPC11453 ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00139 ! oxidized ferredoxin relationship: has_output_compound UPa:UPC11811 {cardinality="1"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_output_compound UPa:UPC11811 ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: part_of UPa:UER00096 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6 relationship: part_of UPa:UER00096 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6 [Term] id: UPa:UCR08716 name: cobalt-factor III = cobalt-precorrin 3 namespace: reaction xref: KEGG:R08716 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC17401 {cardinality="1"} ! cobalt-factor III relationship: has_input_compound UPa:UPC17401 ! cobalt-factor III relationship: has_output_compound UPa:UPC11539 ! cobalt-precorrin 3 relationship: has_output_compound UPa:UPC11539 {cardinality="1"} ! cobalt-precorrin 3 relationship: part_of UPa:UER00224 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 2/10 relationship: part_of UPa:UER00224 {cardinality="1", direction="LR", order="2"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 2/10 [Term] id: UPa:UCR08890 name: 2-deoxy-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate namespace: reaction xref: KEGG:R08890 "KEGG reaction" xref: RHEA:34150 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC17209 ! 2-deoxy-scyllo-inosose relationship: has_input_compound UPa:UPC17209 {cardinality="1"} ! 2-deoxy-scyllo-inosose relationship: has_output_compound UPa:UPC00940 {cardinality="1"} ! 2-oxoglutaramate relationship: has_output_compound UPa:UPC00940 ! 2-oxoglutaramate relationship: has_output_compound UPa:UPC17580 {cardinality="1"} ! 2-deoxy-scyllo-inosamine relationship: has_output_compound UPa:UPC17580 ! 2-deoxy-scyllo-inosamine relationship: part_of UPa:UER00922 ! 2-deoxystreptamine from D-glucose 6-phosphate: step 2/4 relationship: part_of UPa:UER00922 {cardinality="1", direction="LR", order="1"} ! 2-deoxystreptamine from D-glucose 6-phosphate: step 2/4 [Term] id: UPa:UCR08891 name: 3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine = 2-deoxystreptamine + 2-oxoglutaramate namespace: reaction xref: KEGG:R08891 "KEGG reaction" xref: RHEA:34154 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC17581 ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: has_input_compound UPa:UPC17581 {cardinality="1"} ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: has_output_compound UPa:UPC00940 {cardinality="1"} ! 2-oxoglutaramate relationship: has_output_compound UPa:UPC00940 ! 2-oxoglutaramate relationship: has_output_compound UPa:UPC02627 {cardinality="1"} ! 2-deoxystreptamine relationship: has_output_compound UPa:UPC02627 ! 2-deoxystreptamine relationship: part_of UPa:UER00924 ! 2-deoxystreptamine from D-glucose 6-phosphate: step 4/4 relationship: part_of UPa:UER00924 {cardinality="1", direction="LR", order="1"} ! 2-deoxystreptamine from D-glucose 6-phosphate: step 4/4 [Term] id: UPa:UCR08892 name: 2-deoxy-scyllo-inosamine + NAD(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH namespace: reaction xref: KEGG:R08892 "KEGG reaction" xref: RHEA:33886 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC17580 ! 2-deoxy-scyllo-inosamine relationship: has_input_compound UPa:UPC17580 {cardinality="1"} ! 2-deoxy-scyllo-inosamine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC17581 {cardinality="1"} ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: has_output_compound UPa:UPC17581 ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: part_of UPa:UER01031 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER01031 ! None [Term] id: UPa:UCR08947 name: D-fructose 6-phosphate + GDP-alpha-D-mannose = GDP + beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate namespace: reaction xref: KEGG:R08947 "KEGG reaction" xref: METACYC:RXN-9935 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26042 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_output_compound UPa:UPC00035 ! GDP relationship: has_output_compound UPa:UPC18050 ! beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate relationship: has_output_compound UPa:UPC18050 {cardinality="1"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate relationship: part_of UPa:UER01009 ! beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose: step 1/2 relationship: part_of UPa:UER01009 {cardinality="1", direction="LR", order="1"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose: step 1/2 [Term] id: UPa:UCR08982 name: H(2)O + beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate = beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate namespace: reaction xref: KEGG:R08982 "KEGG reaction" xref: METACYC:RXN-9936 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26022 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC18050 {cardinality="1"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate relationship: has_input_compound UPa:UPC18050 ! beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC18068 ! beta-D-fructofuranosyl alpha-D-mannopyranoside relationship: has_output_compound UPa:UPC18068 {cardinality="1"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside relationship: part_of UPa:UER01010 ! beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose: step 2/2 relationship: part_of UPa:UER01010 {cardinality="1", direction="LR", order="1"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose: step 2/2 [Term] id: UPa:UCR09736 name: S-adenosyl-L-methionine + demethylmenaquinol = S-adenosyl-L-homocysteine + menaquinol namespace: reaction xref: KEGG:R09736 "KEGG reaction" xref: RHEA:42643 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC19847 ! demethylmenaquinol relationship: has_input_compound UPa:UPC19847 {cardinality="1"} ! demethylmenaquinol relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC05819 ! menaquinol relationship: has_output_compound UPa:UPC05819 {cardinality="1"} ! menaquinol relationship: part_of UPa:UER00169 {cardinality="1", direction="LR", order="1"} ! menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2 relationship: part_of UPa:UER00169 ! menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2 [Term] id: UPa:UCR09770 name: ATP + D-glycero-alpha-D-manno-heptose 7-phosphate = ADP + D-glycero-alpha-D-manno-heptose 1,7-diphosphate namespace: reaction xref: KEGG:R09770 "KEGG reaction" xref: RHEA:27573 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC19878 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: has_input_compound UPa:UPC19878 ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC19879 ! D-glycero-alpha-D-manno-heptose 1,7-diphosphate relationship: has_output_compound UPa:UPC19879 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 1,7-diphosphate relationship: part_of UPa:UER00606 ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate: step 1/3 relationship: part_of UPa:UER00606 {cardinality="1", direction="LR", order="1"} ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate: step 1/3 [Term] id: UPa:UCR09771 name: D-glycero-alpha-D-manno-heptose 1,7-diphosphate + H(2)O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate namespace: reaction xref: KEGG:R09771 "KEGG reaction" xref: RHEA:28525 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC19879 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 1,7-diphosphate relationship: has_input_compound UPa:UPC19879 ! D-glycero-alpha-D-manno-heptose 1,7-diphosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC19880 ! D-glycero-alpha-D-manno-heptose 1-phosphate relationship: has_output_compound UPa:UPC19880 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 1-phosphate relationship: part_of UPa:UER00607 ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate: step 2/3 relationship: part_of UPa:UER00607 {cardinality="1", direction="LR", order="1"} ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate: step 2/3 [Term] id: UPa:UCR09772 name: D-glycero-alpha-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-alpha-D-manno-heptose + diphosphate namespace: reaction xref: KEGG:R09772 "KEGG reaction" xref: RHEA:27464 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC19880 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 1-phosphate relationship: has_input_compound UPa:UPC19880 ! D-glycero-alpha-D-manno-heptose 1-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC19881 ! GDP-D-glycero-alpha-D-manno-heptose relationship: has_output_compound UPa:UPC19881 {cardinality="1"} ! GDP-D-glycero-alpha-D-manno-heptose relationship: part_of UPa:UER00608 ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate: step 3/3 relationship: part_of UPa:UER00608 {cardinality="1", direction="LR", order="1"} ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate: step 3/3 [Term] id: UPa:UCR09775 name: ATP + L-alpha-aminoadipate + [LysW] = ADP + [LysW]-L-2-aminoadipate + phosphate namespace: reaction xref: KEGG:R09775 "KEGG reaction" xref: RHEA:41943 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC19885 {cardinality="1"} ! [LysW] relationship: has_input_compound UPa:UPC19885 ! [LysW] relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC19886 ! [LysW]-L-2-aminoadipate relationship: has_output_compound UPa:UPC19886 {cardinality="1"} ! [LysW]-L-2-aminoadipate relationship: part_of UPa:UER00035 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (Thermus route): step 1/5 relationship: part_of UPa:UER00035 ! L-lysine from L-alpha-aminoadipate (Thermus route): step 1/5 [Term] id: UPa:UCR09776 name: ATP + [LysW]-L-2-aminoadipate = ADP + [LysW]-L-2-aminoadipyl 6-phosphate namespace: reaction xref: KEGG:R09776 "KEGG reaction" xref: RHEA:41947 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC19886 ! [LysW]-L-2-aminoadipate relationship: has_input_compound UPa:UPC19886 {cardinality="1"} ! [LysW]-L-2-aminoadipate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC19887 ! [LysW]-L-2-aminoadipyl 6-phosphate relationship: has_output_compound UPa:UPC19887 {cardinality="1"} ! [LysW]-L-2-aminoadipyl 6-phosphate relationship: part_of UPa:UER00036 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5 relationship: part_of UPa:UER00036 ! L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5 [Term] id: UPa:UCR09777 name: H(+) + NADPH + [LysW]-L-2-aminoadipyl 6-phosphate = NADP(+) + [LysW]-L-2-aminoadipate 6-semialdehyde + phosphate namespace: reaction xref: KEGG:R09777 "KEGG reaction" xref: RHEA:41951 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC19887 ! [LysW]-L-2-aminoadipyl 6-phosphate relationship: has_input_compound UPa:UPC19887 {cardinality="1"} ! [LysW]-L-2-aminoadipyl 6-phosphate relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC19888 ! [LysW]-L-2-aminoadipate 6-semialdehyde relationship: has_output_compound UPa:UPC19888 {cardinality="1"} ! [LysW]-L-2-aminoadipate 6-semialdehyde relationship: part_of UPa:UER00037 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5 relationship: part_of UPa:UER00037 ! L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5 [Term] id: UPa:UCR09778 name: L-glutamate + [LysW]-L-2-aminoadipate 6-semialdehyde = 2-oxoglutarate + [LysW]-L-lysine namespace: reaction xref: KEGG:R09778 "KEGG reaction" xref: METACYC:RXN-5184 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:41955 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC19888 ! [LysW]-L-2-aminoadipate 6-semialdehyde relationship: has_input_compound UPa:UPC19888 {cardinality="1"} ! [LysW]-L-2-aminoadipate 6-semialdehyde relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC19889 ! [LysW]-L-lysine relationship: has_output_compound UPa:UPC19889 {cardinality="1"} ! [LysW]-L-lysine relationship: part_of UPa:UER00038 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5 relationship: part_of UPa:UER00038 ! L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5 [Term] id: UPa:UCR09779 name: H(2)O + [LysW]-L-lysine = L-lysine + [LysW] namespace: reaction xref: KEGG:R09779 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC19889 ! [LysW]-L-lysine relationship: has_input_compound UPa:UPC19889 {cardinality="1"} ! [LysW]-L-lysine relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_output_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC19885 ! [LysW] relationship: has_output_compound UPa:UPC19885 {cardinality="1"} ! [LysW] relationship: part_of UPa:UER00039 ! L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5 relationship: part_of UPa:UER00039 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5 [Term] id: UPa:UCR10130 name: 2-deoxy-scyllo-inosamine + NADP(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH namespace: reaction xref: KEGG:R10130 "KEGG reaction" xref: RHEA:33882 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC17580 {cardinality="1"} ! 2-deoxy-scyllo-inosamine relationship: has_input_compound UPa:UPC17580 ! 2-deoxy-scyllo-inosamine relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC17581 {cardinality="1"} ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: has_output_compound UPa:UPC17581 ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: part_of UPa:UER01032 {cardinality="1", direction="LR", order="1"} ! None relationship: part_of UPa:UER01032 ! None [Term] id: UPa:UCR10147 name: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(2)O namespace: reaction xref: KEGG:R10147 "KEGG reaction" xref: METACYC:DIHYDRODIPICSYN-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:34174 "Rhea reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_input_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC20258 {cardinality="1"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC20258 ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: part_of UPa:UER00017 {cardinality="1", direction="LR", order="1"} ! (S)-tetrahydrodipicolinate from L-aspartate: step 3/4 relationship: part_of UPa:UER00017 ! (S)-tetrahydrodipicolinate from L-aspartate: step 3/4 [Term] id: UPa:UCR10757 name: 1,4-dihydroxy-2-naphthoate + all-trans-polyprenyl diphosphate = CO(2) + demethylmenaquinol + diphosphate namespace: reaction xref: KEGG:R10757 "KEGG reaction" is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC03657 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoate relationship: has_input_compound UPa:UPC03657 ! 1,4-dihydroxy-2-naphthoate relationship: has_input_compound UPa:UPC05847 {cardinality="1"} ! all-trans-polyprenyl diphosphate relationship: has_input_compound UPa:UPC05847 ! all-trans-polyprenyl diphosphate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC19847 {cardinality="1"} ! demethylmenaquinol relationship: has_output_compound UPa:UPC19847 ! demethylmenaquinol relationship: part_of UPa:UER00168 ! menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2 relationship: part_of UPa:UER00168 {cardinality="1", direction="LR", order="1"} ! menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2 [Term] id: UPa:UCY00012 name: 1-deoxy-D-xylulose 5-phosphate = 4-methyl-5-(2-phosphoethyl)-thiazole namespace: reaction is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC04327 {cardinality="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_output_compound UPa:UPC04327 ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: part_of UPa:UER00140 ! 4-methyl-5-(2-phosphoethyl)-thiazole from 1-deoxy-D-xylulose 5-phosphate: step 1/1 relationship: part_of UPa:UER00140 {cardinality="1", direction="LR", order="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole from 1-deoxy-D-xylulose 5-phosphate: step 1/1 [Term] id: UPa:UCY00016 name: D-alanine + H(2)O + acceptor = NH(3) + pyruvate + reduced acceptor namespace: reaction is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00133 {cardinality="1"} ! D-alanine relationship: has_input_compound UPa:UPC00133 ! D-alanine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: part_of UPa:UER00498 ! NH(3) and pyruvate from D-alanine: step 1/1 relationship: part_of UPa:UER00498 {cardinality="1", direction="LR", order="1"} ! NH(3) and pyruvate from D-alanine: step 1/1 [Term] id: UPa:UCY00018 name: 2 sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate namespace: reaction is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC05382 ! sedoheptulose 7-phosphate relationship: has_input_compound UPa:UPC05382 {cardinality="1"} ! sedoheptulose 7-phosphate relationship: has_output_compound UPa:UPC07836 ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC07836 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC19878 ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC19878 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: part_of UPa:UER00436 {cardinality="1", direction="LR", order="1"} ! D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1 relationship: part_of UPa:UER00436 ! D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1 [Term] id: UPa:UCY00032 name: pectate = 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid + pectate(n-2) namespace: reaction is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00470 ! pectate relationship: has_input_compound UPa:UPC00470 {cardinality="1"} ! pectate relationship: has_output_compound UPa:UPC06118 ! 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid relationship: has_output_compound UPa:UPC06118 {cardinality="1"} ! 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid relationship: has_output_compound UPa:UPX00024 {cardinality="1"} ! pectate(n-2) relationship: has_output_compound UPa:UPX00024 ! pectate(n-2) relationship: part_of UPa:UER00824 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5 relationship: part_of UPa:UER00824 ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5 [Term] id: UPa:UCY00036 name: beta-D-ribofuranose = D-ribose namespace: reaction is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC16639 ! beta-D-ribofuranose relationship: has_input_compound UPa:UPC16639 {cardinality="1"} ! beta-D-ribofuranose relationship: has_output_compound UPa:UPC00121 ! D-ribose relationship: has_output_compound UPa:UPC00121 {cardinality="1"} ! D-ribose relationship: part_of UPa:UER00888 ! D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2 relationship: part_of UPa:UER00888 {cardinality="1", direction="LR", order="2"} ! D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2 [Term] id: UPa:UCY00044 name: 8-amino-7-oxononanoate + L-lysine = 7,8-diaminononanoate + L-2-aminoadipate 6-semialdahyde namespace: reaction is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_input_compound UPa:UPC00047 ! L-lysine relationship: has_input_compound UPa:UPC01092 ! 8-amino-7-oxononanoate relationship: has_input_compound UPa:UPC01092 {cardinality="1"} ! 8-amino-7-oxononanoate relationship: has_output_compound UPa:UPC01037 ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC01037 {cardinality="1"} ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde relationship: part_of UPa:UER00944 {cardinality="1", direction="LR", order="1"} ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (Lys route): step 1/1 relationship: part_of UPa:UER00944 ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (Lys route): step 1/1 [Term] id: UPa:UCY00047 name: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate = 10-deacetyl-2-debenzoylbaccatin III namespace: reaction is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC11898 ! 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate relationship: has_input_compound UPa:UPC11898 {cardinality="1"} ! 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate relationship: has_output_compound UPa:UPC11899 ! 10-deacetyl-2-debenzoylbaccatin III relationship: has_output_compound UPa:UPC11899 {cardinality="1"} ! 10-deacetyl-2-debenzoylbaccatin III relationship: part_of UPa:UER00817 {cardinality="1", direction="LR", order="1"} ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 3/3 relationship: part_of UPa:UER00817 ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 3/3 [Term] id: UPa:UCY00048 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine = 5-amino-1-(5-phospho-D-ribosyl)imidazole namespace: reaction is_a: BFO:0000015 ! process is_a: UPa:UCR00000 ! reaction relationship: has_input_compound UPa:UPC01279 {cardinality="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_input_compound UPa:UPC01279 ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:UER00136 {cardinality="1", direction="RL", order="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 1/3 relationship: part_of UPa:UER00136 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 1/3 [Term] id: UPa:UER00000 name: enzymatic-reaction namespace: enzymatic_reaction def: "An enzymatic-reaction involved in a UniPathway pathway. An enzymatic-reaction is a set of alternate sequence-reactions, catalyzed by the same enzyme. It aims at representing ambiguity on co-substrate/co-product (e.g NAD(P)H." [] [Term] id: UPa:UER00002 name: beta-alanine from L-aspartate: step 1/1 namespace: enzymatic_reaction def: "1 L-aspartate => 1 CO(2) + 1 beta-alanine." [] xref: EC:4.1.1.11 xref: GO:0004068 "molecular_function:aspartate 1-decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00099 ! beta-alanine relationship: has_output_compound UPa:UPC00099 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-alanine relationship: part_of UPa:ULS00002 {cardinality="1", order="1"} ! beta-alanine from L-aspartate relationship: part_of UPa:ULS00002 ! beta-alanine from L-aspartate [Term] id: UPa:UER00003 name: (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2 namespace: enzymatic_reaction def: "1 3-methyl-2-oxobutanoate + 1 5,10-methylene-THF + 1 H(2)O => 1 2-dehydropantoate + 1 5,6,7,8-tetrahydrofolate." [] xref: EC:2.1.2.11 xref: GO:0003864 "molecular_function:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate relationship: has_input_compound UPa:UPC00141 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methyl-2-oxobutanoate relationship: has_input_compound UPa:UPC00143 ! 5,10-methylene-THF relationship: has_input_compound UPa:UPC00143 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,10-methylene-THF relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00966 ! 2-dehydropantoate relationship: has_output_compound UPa:UPC00966 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydropantoate relationship: part_of UPa:ULS00003 {cardinality="1", order="1"} ! (R)-pantoate from 3-methyl-2-oxobutanoate relationship: part_of UPa:ULS00003 ! (R)-pantoate from 3-methyl-2-oxobutanoate [Term] id: UPa:UER00004 name: (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2 namespace: enzymatic_reaction def: "1 2-dehydropantoate + 1 H(+) + 1 NADPH => 1 (R)-pantoate + 1 NADP(+)." [] xref: EC:1.1.1.169 xref: GO:0008677 "molecular_function:2-dehydropantoate 2-reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00966 ! 2-dehydropantoate relationship: has_input_compound UPa:UPC00966 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydropantoate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00522 ! (R)-pantoate relationship: has_output_compound UPa:UPC00522 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-pantoate relationship: part_of UPa:ULS00003 {cardinality="1", order="2"} ! (R)-pantoate from 3-methyl-2-oxobutanoate relationship: part_of UPa:ULS00003 ! (R)-pantoate from 3-methyl-2-oxobutanoate [Term] id: UPa:UER00005 name: (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1 namespace: enzymatic_reaction def: "1 (R)-pantoate + 1 ATP + 1 beta-alanine => 1 (R)-pantothenate + 1 AMP + 1 diphosphate." [] xref: EC:6.3.2.1 xref: GO:0004592 "molecular_function:pantoate-beta-alanine ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00099 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-alanine relationship: has_input_compound UPa:UPC00099 ! beta-alanine relationship: has_input_compound UPa:UPC00522 ! (R)-pantoate relationship: has_input_compound UPa:UPC00522 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-pantoate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00864 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-pantothenate relationship: has_output_compound UPa:UPC00864 ! (R)-pantothenate relationship: part_of UPa:ULS00004 {cardinality="1", order="1"} ! (R)-pantothenate from (R)-pantoate and beta-alanine relationship: part_of UPa:ULS00004 ! (R)-pantothenate from (R)-pantoate and beta-alanine [Term] id: UPa:UER00006 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 ATP => 1 1-(5-phospho-D-ribosyl)-ATP + 1 diphosphate." [] xref: EC:2.4.2.17 xref: GO:0003879 "molecular_function:ATP phosphoribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC02739 ! 1-(5-phospho-D-ribosyl)-ATP relationship: has_output_compound UPa:UPC02739 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-(5-phospho-D-ribosyl)-ATP relationship: part_of UPa:ULS00005 {cardinality="1", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00005 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00007 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9 namespace: enzymatic_reaction def: "1 1-(5-phospho-D-ribosyl)-ATP + 1 H(2)O => 1 1-(5-phosphoribosyl)-5'-AMP + 1 diphosphate." [] xref: EC:3.6.1.31 xref: GO:0004636 "molecular_function:phosphoribosyl-ATP diphosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC02739 ! 1-(5-phospho-D-ribosyl)-ATP relationship: has_input_compound UPa:UPC02739 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-(5-phospho-D-ribosyl)-ATP relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC02741 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-(5-phosphoribosyl)-5'-AMP relationship: has_output_compound UPa:UPC02741 ! 1-(5-phosphoribosyl)-5'-AMP relationship: part_of UPa:ULS00005 {cardinality="1", order="2"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00005 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00008 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9 namespace: enzymatic_reaction def: "1 1-(5-phosphoribosyl)-5'-AMP + 1 H(2)O => 1 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide." [] xref: EC:3.5.4.19 xref: GO:0004635 "molecular_function:phosphoribosyl-AMP cyclohydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC02741 ! 1-(5-phosphoribosyl)-5'-AMP relationship: has_input_compound UPa:UPC02741 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-(5-phosphoribosyl)-5'-AMP relationship: has_output_compound UPa:UPC04896 ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04896 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide relationship: part_of UPa:ULS00005 {cardinality="1", order="3"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00005 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00009 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9 namespace: enzymatic_reaction def: "1 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide => 1 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide." [] xref: EC:5.3.1.16 xref: GO:0003949 "molecular_function:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04896 ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04896 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04916 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04916 ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00005 {cardinality="1", order="4"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00005 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00010 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9 namespace: enzymatic_reaction def: "1 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + 1 L-glutamine => 1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 1 D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 1 L-glutamate." [] xref: EC:2.4.2 xref: EC:4.1.3 xref: GO:0000107 "molecular_function:imidazoleglycerol-phosphate synthase activity" xref: GO:0016763 "molecular_function:transferase activity, transferring pentosyl groups" xref: GO:0016833 "molecular_function:oxo-acid-lyase activity" xref: GO:0018071 "molecular_function:NAD(P)-cysteine ADP-ribosyltransferase activity" xref: GO:0018121 "molecular_function:NAD(P)-asparagine ADP-ribosyltransferase activity" xref: GO:0018127 "molecular_function:NAD(P)-serine ADP-ribosyltransferase activity" xref: GO:0034815 "molecular_function:cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity" xref: GO:0034830 "molecular_function:(2Z)-2,4-dihydroxydec-2-enedioate aldolase activity" xref: GO:0034905 "molecular_function:5-chloro-4-hydroxy-2-oxopentanate aldolase activity" xref: GO:0043867 "molecular_function:7-cyano-7-deazaguanine tRNA-ribosyltransferase activity" xref: GO:0043904 "molecular_function:isochorismate pyruvate lyase activity" xref: GO:0043959 "molecular_function:L-erythro-3-methylmalyl-CoA lyase activity" xref: GO:0044101 "molecular_function:(R)-citramalyl-CoA lyase activity" xref: GO:0044102 "molecular_function:purine deoxyribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC04916 ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04916 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC04666 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_output_compound UPa:UPC04666 ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_output_compound UPa:UPC04677 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00005 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00005 {cardinality="1", order="5"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00011 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9 namespace: enzymatic_reaction def: "1 D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate => 1 H(2)O + 1 imidazole-acetol phosphate." [] xref: EC:4.2.1.19 xref: GO:0004424 "molecular_function:imidazoleglycerol-phosphate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04666 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_input_compound UPa:UPC04666 ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC01267 {cardinality="1", is_alternate="False", is_primary="True"} ! imidazole-acetol phosphate relationship: has_output_compound UPa:UPC01267 ! imidazole-acetol phosphate relationship: part_of UPa:ULS00005 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00005 {cardinality="1", order="6"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00012 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9 namespace: enzymatic_reaction def: "1 L-glutamate + 1 imidazole-acetol phosphate => 1 2-oxoglutarate + 1 L-histidinol phosphate." [] xref: EC:2.6.1.9 xref: GO:0004400 "molecular_function:histidinol-phosphate transaminase activity" xref: GO:0080130 "molecular_function:L-phenylalanine:2-oxoglutarate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC01267 ! imidazole-acetol phosphate relationship: has_input_compound UPa:UPC01267 {cardinality="1", is_alternate="False", is_primary="True"} ! imidazole-acetol phosphate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC01100 {cardinality="1", is_alternate="False", is_primary="True"} ! L-histidinol phosphate relationship: has_output_compound UPa:UPC01100 ! L-histidinol phosphate relationship: part_of UPa:ULS00005 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00005 {cardinality="1", order="7"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00013 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-histidinol phosphate => 1 L-histidinol + 1 phosphate." [] xref: EC:3.1.3.15 xref: GO:0004401 "molecular_function:histidinol-phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01100 {cardinality="1", is_alternate="False", is_primary="True"} ! L-histidinol phosphate relationship: has_input_compound UPa:UPC01100 ! L-histidinol phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00860 ! L-histidinol relationship: has_output_compound UPa:UPC00860 {cardinality="1", is_alternate="False", is_primary="True"} ! L-histidinol relationship: part_of UPa:ULS00005 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00005 {cardinality="1", order="8"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00014 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-histidinol + 2 NAD(+) => 2 H(+) + 1 L-histidine + 2 NADH." [] xref: EC:1.1.1.23 xref: GO:0004399 "molecular_function:histidinol dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00860 ! L-histidinol relationship: has_input_compound UPa:UPC00860 {cardinality="1", is_alternate="False", is_primary="True"} ! L-histidinol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00135 {cardinality="1", is_alternate="False", is_primary="True"} ! L-histidine relationship: has_output_compound UPa:UPC00135 ! L-histidine relationship: part_of UPa:ULS00005 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00005 {cardinality="1", order="9"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00015 name: (S)-tetrahydrodipicolinate from L-aspartate: step 1/4 namespace: enzymatic_reaction def: "1 ATP + 1 L-aspartate => 1 4-phospho-L-aspartate + 1 ADP." [] xref: EC:2.7.2.4 xref: GO:0004072 "molecular_function:aspartate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC03082 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-phospho-L-aspartate relationship: has_output_compound UPa:UPC03082 ! 4-phospho-L-aspartate relationship: part_of UPa:ULS00006 ! (S)-tetrahydrodipicolinate from L-aspartate relationship: part_of UPa:ULS00006 {cardinality="1", order="1"} ! (S)-tetrahydrodipicolinate from L-aspartate [Term] id: UPa:UER00016 name: (S)-tetrahydrodipicolinate from L-aspartate: step 2/4 namespace: enzymatic_reaction def: "1 4-phospho-L-aspartate + 1 H(+) + 1 NADPH => 1 L-aspartate 4-semialdehyde + 1 NADP(+) + 1 phosphate." [] xref: EC:1.2.1.11 xref: GO:0004073 "molecular_function:aspartate-semialdehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC03082 ! 4-phospho-L-aspartate relationship: has_input_compound UPa:UPC03082 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-phospho-L-aspartate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: part_of UPa:ULS00006 ! (S)-tetrahydrodipicolinate from L-aspartate relationship: part_of UPa:ULS00006 {cardinality="1", order="2"} ! (S)-tetrahydrodipicolinate from L-aspartate [Term] id: UPa:UER00017 name: (S)-tetrahydrodipicolinate from L-aspartate: step 3/4 namespace: enzymatic_reaction def: "1 L-aspartate 4-semialdehyde + 1 pyruvate => 1 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + 1 H(2)O." [] xref: EC:4.3.3.7 xref: GO:0008840 "molecular_function:4-hydroxy-tetrahydrodipicolinate synthase" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_input_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC20258 ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC20258 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: part_of UPa:ULS00006 ! (S)-tetrahydrodipicolinate from L-aspartate relationship: part_of UPa:ULS00006 {cardinality="1", order="3"} ! (S)-tetrahydrodipicolinate from L-aspartate [Term] id: UPa:UER00018 name: (S)-tetrahydrodipicolinate from L-aspartate: step 4/4 namespace: enzymatic_reaction def: "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + [NADH or NADPH] => (S)-tetrahydrodipicolinate + H(2)O + [NAD(+) or NADP(+)]." [] xref: EC:1.17.1.8 xref: GO:0008839 "molecular_function:4-hydroxy-tetrahydrodipicolinate reductase" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER01028 ! None relationship: has_alternate_enzymatic_reaction UPa:UER01029 ! None relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC20258 ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC20258 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC03972 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: part_of UPa:ULS00006 ! (S)-tetrahydrodipicolinate from L-aspartate relationship: part_of UPa:ULS00006 {cardinality="1", order="4"} ! (S)-tetrahydrodipicolinate from L-aspartate [Term] id: UPa:UER00019 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3 namespace: enzymatic_reaction def: "1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 succinyl-CoA => 1 CoA + 1 L-2-succinylamino-6-oxopimelate." [] xref: EC:2.3.1.117 xref: GO:0008666 "molecular_function:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="False"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC03972 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC04462 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-succinylamino-6-oxopimelate relationship: has_output_compound UPa:UPC04462 ! L-2-succinylamino-6-oxopimelate relationship: part_of UPa:ULS00007 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) relationship: part_of UPa:ULS00007 {cardinality="1", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) [Term] id: UPa:UER00020 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3 namespace: enzymatic_reaction def: "1 L-2-succinylamino-6-oxopimelate + 1 L-glutamate => 1 2-oxoglutarate + 1 N-succinyl-LL-2,6-diaminopimelate." [] xref: EC:2.6.1.17 xref: GO:0009016 "molecular_function:succinyldiaminopimelate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC04462 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-succinylamino-6-oxopimelate relationship: has_input_compound UPa:UPC04462 ! L-2-succinylamino-6-oxopimelate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC04421 ! N-succinyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC04421 {cardinality="1", is_alternate="False", is_primary="True"} ! N-succinyl-LL-2,6-diaminopimelate relationship: part_of UPa:ULS00007 {cardinality="1", order="2"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) relationship: part_of UPa:ULS00007 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) [Term] id: UPa:UER00021 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-succinyl-LL-2,6-diaminopimelate => 1 LL-2,6-diaminopimelate + 1 succinate." [] xref: EC:3.5.1.18 xref: GO:0009014 "molecular_function:succinyl-diaminopimelate desuccinylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04421 {cardinality="1", is_alternate="False", is_primary="True"} ! N-succinyl-LL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC04421 ! N-succinyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00666 {cardinality="1", is_alternate="False", is_primary="True"} ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00666 ! LL-2,6-diaminopimelate relationship: part_of UPa:ULS00007 {cardinality="1", order="3"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) relationship: part_of UPa:ULS00007 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) [Term] id: UPa:UER00022 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3 namespace: enzymatic_reaction def: "1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 acetyl-CoA => 1 (S)-2-acetamido-6-oxopimelate + 1 CoA." [] xref: EC:2.3.1.89 xref: GO:0047200 "molecular_function:tetrahydrodipicolinate N-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC03972 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC05539 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetamido-6-oxopimelate relationship: has_output_compound UPa:UPC05539 ! (S)-2-acetamido-6-oxopimelate relationship: part_of UPa:ULS00008 {cardinality="1", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route) relationship: part_of UPa:ULS00008 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route) [Term] id: UPa:UER00023 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 2/3 namespace: enzymatic_reaction def: "1 (S)-2-acetamido-6-oxopimelate + 1 L-glutamate => 1 2-oxoglutarate + 1 N-acetyl-LL-2,6-diaminopimelate." [] xref: EC:2.6.1 xref: GO:0008483 "molecular_function:transaminase activity" xref: GO:0010326 "molecular_function:methionine-oxo-acid transaminase activity" xref: GO:0018719 "molecular_function:6-aminohexanoate transaminase activity" xref: GO:0043746 "molecular_function:N2-acetyl-L-lysine aminotransferase activity" xref: GO:0043760 "molecular_function:acetyldiaminopimelate aminotransferase activity" xref: GO:0043840 "molecular_function:branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" xref: GO:0043911 "molecular_function:D-lysine transaminase activity" xref: GO:0046571 "molecular_function:aspartate-2-keto-4-methylthiobutyrate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC05539 ! (S)-2-acetamido-6-oxopimelate relationship: has_input_compound UPa:UPC05539 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetamido-6-oxopimelate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC04390 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC04390 ! N-acetyl-LL-2,6-diaminopimelate relationship: part_of UPa:ULS00008 {cardinality="1", order="2"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route) relationship: part_of UPa:ULS00008 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route) [Term] id: UPa:UER00024 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-acetyl-LL-2,6-diaminopimelate => 1 LL-2,6-diaminopimelate + 1 acetate." [] xref: EC:3.5.1.47 xref: GO:0050118 "molecular_function:N-acetyldiaminopimelate deacetylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04390 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-LL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC04390 ! N-acetyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00666 {cardinality="1", is_alternate="False", is_primary="True"} ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00666 ! LL-2,6-diaminopimelate relationship: part_of UPa:ULS00008 {cardinality="1", order="3"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route) relationship: part_of UPa:ULS00008 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route) [Term] id: UPa:UER00025 name: DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1 namespace: enzymatic_reaction def: "1 LL-2,6-diaminopimelate => 1 DL-2,6-diaminopimelate." [] xref: EC:5.1.1.7 xref: GO:0008837 "molecular_function:diaminopimelate epimerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00666 {cardinality="1", is_alternate="False", is_primary="True"} ! LL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC00666 ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00680 {cardinality="1", is_alternate="False", is_primary="True"} ! DL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00680 ! DL-2,6-diaminopimelate relationship: part_of UPa:ULS00009 {cardinality="1", order="1"} ! DL-2,6-diaminopimelate from LL-2,6-diaminopimelate relationship: part_of UPa:ULS00009 ! DL-2,6-diaminopimelate from LL-2,6-diaminopimelate [Term] id: UPa:UER00026 name: DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1 namespace: enzymatic_reaction def: "1 (S)-tetrahydrodipicolinate + 1 H(+) + 1 H(2)O + 1 NADPH + 1 NH(3) => 1 DL-2,6-diaminopimelate + 1 NADP(+)." [] xref: EC:1.4.1.16 xref: GO:0047850 "molecular_function:diaminopimelate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC03972 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00680 {cardinality="1", is_alternate="False", is_primary="True"} ! DL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00680 ! DL-2,6-diaminopimelate relationship: part_of UPa:ULS00010 {cardinality="1", order="1"} ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate relationship: part_of UPa:ULS00010 ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate [Term] id: UPa:UER00027 name: L-lysine from DL-2,6-diaminopimelate: step 1/1 namespace: enzymatic_reaction def: "1 DL-2,6-diaminopimelate => 1 CO(2) + 1 L-lysine." [] xref: EC:4.1.1.20 xref: GO:0008836 "molecular_function:diaminopimelate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00680 ! DL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC00680 {cardinality="1", is_alternate="False", is_primary="True"} ! DL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC00047 {cardinality="1", is_alternate="False", is_primary="True"} ! L-lysine relationship: part_of UPa:ULS00011 {cardinality="1", order="1"} ! L-lysine from DL-2,6-diaminopimelate relationship: part_of UPa:ULS00011 ! L-lysine from DL-2,6-diaminopimelate [Term] id: UPa:UER00028 name: L-alpha-aminoadipate from 2-oxoglutarate: step 1/5 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 H(2)O + 1 acetyl-CoA => 1 (R)-homocitrate + 1 CoA." [] xref: EC:2.3.3.14 xref: GO:0004410 "molecular_function:homocitrate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC01251 ! (R)-homocitrate relationship: has_output_compound UPa:UPC01251 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-homocitrate relationship: part_of UPa:ULS00012 {cardinality="1", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate relationship: part_of UPa:ULS00012 ! L-alpha-aminoadipate from 2-oxoglutarate [Term] id: UPa:UER00029 name: L-alpha-aminoadipate from 2-oxoglutarate: step 2/5 namespace: enzymatic_reaction def: "1 (R)-homocitrate => 1 H(2)O + 1 homo-cis-aconitate." [] xref: EC:4.2.1 xref: GO:0008659 "molecular_function:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity" xref: GO:0016836 "molecular_function:hydro-lyase activity" xref: GO:0018807 "molecular_function:6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity" xref: GO:0018808 "molecular_function:trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity" xref: GO:0018809 "molecular_function:E-phenylitaconyl-CoA hydratase activity" xref: GO:0018810 "molecular_function:trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity" xref: GO:0018811 "molecular_function:cyclohex-1-ene-1-carboxyl-CoA hydratase activity" xref: GO:0018812 "molecular_function:3-hydroxyacyl-CoA dehydratase activity" xref: GO:0018813 "molecular_function:trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity" xref: GO:0018815 "molecular_function:3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity" xref: GO:0018816 "molecular_function:2-hydroxyisobutyrate dehydratase activity" xref: GO:0018817 "molecular_function:2-oxo-hept-3-ene-1,7-dioate hydratase activity" xref: GO:0034561 "molecular_function:1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity" xref: GO:0034578 "molecular_function:limonene 8-hydratase activity" xref: GO:0034581 "molecular_function:4-methyloct-2-enoyl-CoA hydratase activity" xref: GO:0034829 "molecular_function:2-hydroxydec-2,4-diene-1,10-dioate hydratase activity" xref: GO:0034839 "molecular_function:menth-2-enone hydratase activity" xref: GO:0034846 "molecular_function:naphthyl-2-methylene-succinyl-CoA lyase activity" xref: GO:0034856 "molecular_function:2-hydroxyhexa-2,4-dienoate hydratase activity" xref: GO:0034867 "molecular_function:2,4,4-trimethylpent-2-enoyl-CoA hydratase activity" xref: GO:0034890 "molecular_function:endosulfan diol hydrolyase (cyclizing) activity" xref: GO:0034904 "molecular_function:5-chloro-2-oxopent-4-enoate hydratase activity" xref: GO:0034917 "molecular_function:2-methylhex-2-enoyl-CoA hydratase activity" xref: GO:0034953 "molecular_function:perillyl-CoA hydratase activity" xref: GO:0043724 "molecular_function:2-keto-3-deoxygalactonate aldolase activity" xref: GO:0043725 "molecular_function:2-keto-3-deoxygluconate aldolase activity" xref: GO:0043956 "molecular_function:3-hydroxypropionyl-CoA dehydratase activity" xref: GO:0043960 "molecular_function:L-erythro-3-methylmalyl-CoA dehydratase activity" xref: GO:0046565 "molecular_function:3-dehydroshikimate dehydratase activity" xref: GO:0051909 "molecular_function:acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate" xref: GO:0052684 "molecular_function:L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity" xref: GO:0052855 "molecular_function:ADP-dependent NAD(P)H-hydrate dehydratase activity" xref: GO:0070497 "molecular_function:6-carboxy-5,6,7,8-tetrahydropterin synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01251 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-homocitrate relationship: has_input_compound UPa:UPC01251 ! (R)-homocitrate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC04002 ! homo-cis-aconitate relationship: has_output_compound UPa:UPC04002 {cardinality="1", is_alternate="False", is_primary="True"} ! homo-cis-aconitate relationship: part_of UPa:ULS00012 {cardinality="1", order="2"} ! L-alpha-aminoadipate from 2-oxoglutarate relationship: part_of UPa:ULS00012 ! L-alpha-aminoadipate from 2-oxoglutarate [Term] id: UPa:UER00030 name: L-alpha-aminoadipate from 2-oxoglutarate: step 4/5 namespace: enzymatic_reaction def: "1 NAD(+) + 1 homoisocitrate => 1 2-oxoadipate + 1 CO(2) + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.87 xref: GO:0047046 "molecular_function:homoisocitrate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC05662 {cardinality="1", is_alternate="False", is_primary="True"} ! homoisocitrate relationship: has_input_compound UPa:UPC05662 ! homoisocitrate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00322 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoadipate relationship: has_output_compound UPa:UPC00322 ! 2-oxoadipate relationship: part_of UPa:ULS00012 ! L-alpha-aminoadipate from 2-oxoglutarate relationship: part_of UPa:ULS00012 {cardinality="1", order="4"} ! L-alpha-aminoadipate from 2-oxoglutarate [Term] id: UPa:UER00031 name: L-alpha-aminoadipate from 2-oxoglutarate: step 5/5 namespace: enzymatic_reaction def: "1 2-oxoadipate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-alpha-aminoadipate." [] xref: EC:2.6.1.39 xref: GO:0047536 "molecular_function:2-aminoadipate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00322 ! 2-oxoadipate relationship: has_input_compound UPa:UPC00322 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoadipate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: part_of UPa:ULS00012 ! L-alpha-aminoadipate from 2-oxoglutarate relationship: part_of UPa:ULS00012 {cardinality="1", order="5"} ! L-alpha-aminoadipate from 2-oxoglutarate [Term] id: UPa:UER00032 name: L-lysine from L-alpha-aminoadipate (fungal route): step 1/3 namespace: enzymatic_reaction def: "1 ATP + 1 H(+) + 1 L-alpha-aminoadipate + 1 NADPH => 1 AMP + 1 L-2-aminoadipate 6-semialdahyde + 1 NADP(+) + 1 diphosphate + 1 holo-Lys2." [] xref: EC:1.2.1.31 xref: GO:0004043 "molecular_function:L-aminoadipate-semialdehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC04076 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC11482 ! holo-Lys2 relationship: has_output_compound UPa:UPC11482 {cardinality="1", is_alternate="False", is_primary="False"} ! holo-Lys2 relationship: part_of UPa:ULS00013 ! L-lysine from L-alpha-aminoadipate (fungal route) relationship: part_of UPa:ULS00013 {cardinality="1", order="1"} ! L-lysine from L-alpha-aminoadipate (fungal route) [Term] id: UPa:UER00033 name: L-lysine from L-alpha-aminoadipate (fungal route): step 2/3 namespace: enzymatic_reaction def: "1 H(+) + 1 L-2-aminoadipate 6-semialdahyde + 1 L-glutamate + 1 NADPH => 1 H(2)O + 1 NADP(+) + 1 saccharopine." [] xref: EC:1.5.1.10 xref: GO:0004755 "molecular_function:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: has_input_compound UPa:UPC04076 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00449 ! saccharopine relationship: has_output_compound UPa:UPC00449 {cardinality="1", is_alternate="False", is_primary="True"} ! saccharopine relationship: part_of UPa:ULS00013 ! L-lysine from L-alpha-aminoadipate (fungal route) relationship: part_of UPa:ULS00013 {cardinality="1", order="2"} ! L-lysine from L-alpha-aminoadipate (fungal route) [Term] id: UPa:UER00034 name: L-lysine from L-alpha-aminoadipate (fungal route): step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 saccharopine => 1 2-oxoglutarate + 1 H(+) + 1 L-lysine + 1 NADH." [] xref: EC:1.5.1.7 xref: GO:0004754 "molecular_function:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00449 {cardinality="1", is_alternate="False", is_primary="True"} ! saccharopine relationship: has_input_compound UPa:UPC00449 ! saccharopine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC00047 {cardinality="1", is_alternate="False", is_primary="True"} ! L-lysine relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: part_of UPa:ULS00013 ! L-lysine from L-alpha-aminoadipate (fungal route) relationship: part_of UPa:ULS00013 {cardinality="1", order="3"} ! L-lysine from L-alpha-aminoadipate (fungal route) [Term] id: UPa:UER00035 name: L-lysine from L-alpha-aminoadipate (Thermus route): step 1/5 namespace: enzymatic_reaction def: "1 ATP + 1 L-alpha-aminoadipate + 1 [LysW] => 1 ADP + 1 [LysW]-L-2-aminoadipate + 1 phosphate." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC19885 ! [LysW] relationship: has_input_compound UPa:UPC19885 {cardinality="1", is_alternate="False", is_primary="False"} ! [LysW] relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC19886 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-2-aminoadipate relationship: has_output_compound UPa:UPC19886 ! [LysW]-L-2-aminoadipate relationship: part_of UPa:ULS00014 ! L-lysine from L-alpha-aminoadipate (Thermus route) relationship: part_of UPa:ULS00014 {cardinality="1", order="1"} ! L-lysine from L-alpha-aminoadipate (Thermus route) [Term] id: UPa:UER00036 name: L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5 namespace: enzymatic_reaction def: "1 ATP + 1 [LysW]-L-2-aminoadipate => 1 ADP + 1 [LysW]-L-2-aminoadipyl 6-phosphate." [] xref: EC:2.7.2 xref: GO:0016774 "molecular_function:phosphotransferase activity, carboxyl group as acceptor" xref: GO:0036357 "molecular_function:2-phosphoglycerate kinase activity" xref: GO:0043744 "molecular_function:N2-acetyl-L-aminoadipate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC19886 ! [LysW]-L-2-aminoadipate relationship: has_input_compound UPa:UPC19886 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-2-aminoadipate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC19887 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-2-aminoadipyl 6-phosphate relationship: has_output_compound UPa:UPC19887 ! [LysW]-L-2-aminoadipyl 6-phosphate relationship: part_of UPa:ULS00014 ! L-lysine from L-alpha-aminoadipate (Thermus route) relationship: part_of UPa:ULS00014 {cardinality="1", order="2"} ! L-lysine from L-alpha-aminoadipate (Thermus route) [Term] id: UPa:UER00037 name: L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 [LysW]-L-2-aminoadipyl 6-phosphate => 1 NADP(+) + 1 [LysW]-L-2-aminoadipate 6-semialdehyde + 1 phosphate." [] xref: EC:1.2.1 xref: GO:0004028 "molecular_function:3-chloroallyl aldehyde dehydrogenase activity" xref: GO:0016620 "molecular_function:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" xref: GO:0018472 "molecular_function:1-hydroxy-2-naphthaldehyde dehydrogenase activity" xref: GO:0018473 "molecular_function:cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity" xref: GO:0018474 "molecular_function:2-carboxybenzaldehyde dehydrogenase activity" xref: GO:0018475 "molecular_function:trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity" xref: GO:0019115 "molecular_function:benzaldehyde dehydrogenase activity" xref: GO:0034520 "molecular_function:2-naphthaldehyde dehydrogenase activity" xref: GO:0034525 "molecular_function:1-naphthaldehyde dehydrogenase activity" xref: GO:0034530 "molecular_function:4-hydroxymethylsalicyaldehyde dehydrogenase activity" xref: GO:0034538 "molecular_function:3-methylsalicylaldehyde dehydrogenase activity" xref: GO:0034601 "molecular_function:oxoglutarate dehydrogenase [NAD(P)+] activity" xref: GO:0034602 "molecular_function:oxoglutarate dehydrogenase (NAD+) activity" xref: GO:0034603 "molecular_function:pyruvate dehydrogenase [NAD(P)+] activity" xref: GO:0034604 "molecular_function:pyruvate dehydrogenase (NAD+) activity" xref: GO:0034822 "molecular_function:citronellal dehydrogenase activity" xref: GO:0034832 "molecular_function:geranial dehydrogenase activity" xref: GO:0043745 "molecular_function:N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity" xref: GO:0043796 "molecular_function:glyceraldehyde dehydrogenase (NADP) activity" xref: GO:0043870 "molecular_function:N-acetyl-gamma-aminoadipyl-phosphate reductase activity" xref: GO:0043878 "molecular_function:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity" xref: GO:0044104 "molecular_function:2,5-dioxovalerate dehydrogenase (NAD+) activity" xref: GO:0052814 "molecular_function:medium-chain-aldehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC19887 ! [LysW]-L-2-aminoadipyl 6-phosphate relationship: has_input_compound UPa:UPC19887 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-2-aminoadipyl 6-phosphate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC19888 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-2-aminoadipate 6-semialdehyde relationship: has_output_compound UPa:UPC19888 ! [LysW]-L-2-aminoadipate 6-semialdehyde relationship: part_of UPa:ULS00014 ! L-lysine from L-alpha-aminoadipate (Thermus route) relationship: part_of UPa:ULS00014 {cardinality="1", order="3"} ! L-lysine from L-alpha-aminoadipate (Thermus route) [Term] id: UPa:UER00038 name: L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5 namespace: enzymatic_reaction def: "1 L-glutamate + 1 [LysW]-L-2-aminoadipate 6-semialdehyde => 1 2-oxoglutarate + 1 [LysW]-L-lysine." [] xref: EC:2.6.1 xref: GO:0008483 "molecular_function:transaminase activity" xref: GO:0010326 "molecular_function:methionine-oxo-acid transaminase activity" xref: GO:0018719 "molecular_function:6-aminohexanoate transaminase activity" xref: GO:0043746 "molecular_function:N2-acetyl-L-lysine aminotransferase activity" xref: GO:0043760 "molecular_function:acetyldiaminopimelate aminotransferase activity" xref: GO:0043840 "molecular_function:branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" xref: GO:0043911 "molecular_function:D-lysine transaminase activity" xref: GO:0046571 "molecular_function:aspartate-2-keto-4-methylthiobutyrate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC19888 ! [LysW]-L-2-aminoadipate 6-semialdehyde relationship: has_input_compound UPa:UPC19888 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-2-aminoadipate 6-semialdehyde relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC19889 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-lysine relationship: has_output_compound UPa:UPC19889 ! [LysW]-L-lysine relationship: part_of UPa:ULS00014 ! L-lysine from L-alpha-aminoadipate (Thermus route) relationship: part_of UPa:ULS00014 {cardinality="1", order="4"} ! L-lysine from L-alpha-aminoadipate (Thermus route) [Term] id: UPa:UER00039 name: L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 [LysW]-L-lysine => 1 L-lysine + 1 [LysW]." [] xref: EC:3.5.1 xref: GO:0008418 "molecular_function:protein-N-terminal asparagine amidohydrolase activity" xref: GO:0008759 "molecular_function:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity" xref: GO:0016811 "molecular_function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" xref: GO:0018748 "molecular_function:iprodione amidohydrolase activity" xref: GO:0018749 "molecular_function:(3,5-dichlorophenylurea)acetate amidohydrolase activity" xref: GO:0034571 "molecular_function:4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity" xref: GO:0034573 "molecular_function:didemethylisoproturon amidohydrolase activity" xref: GO:0034576 "molecular_function:N-isopropylacetanilide amidohydrolase activity" xref: GO:0034781 "molecular_function:N-cyclohexylformamide amidohydrolase activity" xref: GO:0034876 "molecular_function:isonicotinic acid hydrazide hydrolase activity" xref: GO:0034882 "molecular_function:cis-aconitamide amidase activity" xref: GO:0034885 "molecular_function:gamma-N-formylaminovinylacetate hydrolase activity" xref: GO:0043747 "molecular_function:N2-acetyl-L-lysine deacetylase activity" xref: GO:0043748 "molecular_function:O-succinylbenzoate synthase activity" xref: GO:0043864 "molecular_function:indoleacetamide hydrolase activity" xref: GO:0043909 "molecular_function:N-acetylcitrulline deacetylase activity" xref: GO:0047419 "molecular_function:N-acetylgalactosamine-6-phosphate deacetylase activity" xref: GO:0052773 "molecular_function:diacetylchitobiose deacetylase activity" xref: GO:0052790 "molecular_function:chitooligosaccharide deacetylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC19889 ! [LysW]-L-lysine relationship: has_input_compound UPa:UPC19889 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-lysine relationship: has_output_compound UPa:UPC00047 {cardinality="1", is_alternate="False", is_primary="True"} ! L-lysine relationship: has_output_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC19885 {cardinality="1", is_alternate="False", is_primary="False"} ! [LysW] relationship: has_output_compound UPa:UPC19885 ! [LysW] relationship: part_of UPa:ULS00014 ! L-lysine from L-alpha-aminoadipate (Thermus route) relationship: part_of UPa:ULS00014 {cardinality="1", order="5"} ! L-lysine from L-alpha-aminoadipate (Thermus route) [Term] id: UPa:UER00040 name: L-tryptophan from chorismate: step 1/5 namespace: enzymatic_reaction def: "1 L-glutamine + 1 NH(3) + 1 chorismate => 1 L-glutamate + 1 anthranilate + 1 pyruvate." [] xref: EC:4.1.3.27 xref: GO:0004049 "molecular_function:anthranilate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00251 {cardinality="1", is_alternate="False", is_primary="True"} ! chorismate relationship: has_input_compound UPa:UPC00251 ! chorismate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00108 ! anthranilate relationship: has_output_compound UPa:UPC00108 {cardinality="1", is_alternate="False", is_primary="True"} ! anthranilate relationship: part_of UPa:ULS00016 {cardinality="1", order="1"} ! L-tryptophan from chorismate relationship: part_of UPa:ULS00016 ! L-tryptophan from chorismate [Term] id: UPa:UER00041 name: L-tryptophan from chorismate: step 2/5 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 anthranilate => 1 N-(5-phospho-beta-D-ribosyl)anthranilic acid + 1 diphosphate." [] xref: EC:2.4.2.18 xref: GO:0004048 "molecular_function:anthranilate phosphoribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00108 {cardinality="1", is_alternate="False", is_primary="True"} ! anthranilate relationship: has_input_compound UPa:UPC00108 ! anthranilate relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC04302 {cardinality="1", is_alternate="False", is_primary="True"} ! N-(5-phospho-beta-D-ribosyl)anthranilic acid relationship: has_output_compound UPa:UPC04302 ! N-(5-phospho-beta-D-ribosyl)anthranilic acid relationship: part_of UPa:ULS00016 {cardinality="1", order="2"} ! L-tryptophan from chorismate relationship: part_of UPa:ULS00016 ! L-tryptophan from chorismate [Term] id: UPa:UER00042 name: L-tryptophan from chorismate: step 3/5 namespace: enzymatic_reaction def: "1 N-(5-phospho-beta-D-ribosyl)anthranilic acid => 1 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [] xref: EC:5.3.1.24 xref: GO:0004640 "molecular_function:phosphoribosylanthranilate isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04302 ! N-(5-phospho-beta-D-ribosyl)anthranilic acid relationship: has_input_compound UPa:UPC04302 {cardinality="1", is_alternate="False", is_primary="True"} ! N-(5-phospho-beta-D-ribosyl)anthranilic acid relationship: has_output_compound UPa:UPC01302 ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC01302 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate relationship: part_of UPa:ULS00016 {cardinality="1", order="3"} ! L-tryptophan from chorismate relationship: part_of UPa:ULS00016 ! L-tryptophan from chorismate [Term] id: UPa:UER00043 name: L-tryptophan from chorismate: step 4/5 namespace: enzymatic_reaction def: "1 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate => 1 CO(2) + 1 H(2)O + 1 indoleglycerol phosphate." [] xref: EC:4.1.1.48 xref: GO:0004425 "molecular_function:indole-3-glycerol-phosphate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01302 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC01302 ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC03506 ! indoleglycerol phosphate relationship: has_output_compound UPa:UPC03506 {cardinality="1", is_alternate="False", is_primary="True"} ! indoleglycerol phosphate relationship: part_of UPa:ULS00016 {cardinality="1", order="4"} ! L-tryptophan from chorismate relationship: part_of UPa:ULS00016 ! L-tryptophan from chorismate [Term] id: UPa:UER00044 name: L-tryptophan from chorismate: step 5/5 namespace: enzymatic_reaction def: "1 L-serine + 1 indoleglycerol phosphate => 1 D-glyceraldehyde 3-phosphate + 1 H(2)O + 1 L-tryptophan." [] xref: EC:4.2.1.20 xref: GO:0004834 "molecular_function:tryptophan synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="False"} ! L-serine relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC03506 ! indoleglycerol phosphate relationship: has_input_compound UPa:UPC03506 {cardinality="1", is_alternate="False", is_primary="True"} ! indoleglycerol phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00078 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tryptophan relationship: has_output_compound UPa:UPC00078 ! L-tryptophan relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="False"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00016 {cardinality="1", order="5"} ! L-tryptophan from chorismate relationship: part_of UPa:ULS00016 ! L-tryptophan from chorismate [Term] id: UPa:UER00053 name: taxol from baccatin III: step 3/3 namespace: enzymatic_reaction def: "1 N-(3'R)-debenzoyltaxol + 1 benzoyl-CoA => 1 CoA + 1 taxol." [] xref: EC:2.3.1 xref: GO:0004147 "molecular_function:dihydrolipoamide branched chain acyltransferase activity" xref: GO:0004772 "molecular_function:sterol O-acyltransferase activity" xref: GO:0008080 "molecular_function:N-acetyltransferase activity" xref: GO:0008374 "molecular_function:O-acyltransferase activity" xref: GO:0008951 "molecular_function:palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity" xref: GO:0016406 "molecular_function:carnitine O-acyltransferase activity" xref: GO:0016407 "molecular_function:acetyltransferase activity" xref: GO:0016408 "molecular_function:C-acyltransferase activity" xref: GO:0016409 "molecular_function:palmitoyltransferase activity" xref: GO:0016410 "molecular_function:N-acyltransferase activity" xref: GO:0016411 "molecular_function:acylglycerol O-acyltransferase activity" xref: GO:0016412 "molecular_function:serine O-acyltransferase activity" xref: GO:0016413 "molecular_function:O-acetyltransferase activity" xref: GO:0016414 "molecular_function:O-octanoyltransferase activity" xref: GO:0016415 "molecular_function:octanoyltransferase activity" xref: GO:0016416 "molecular_function:O-palmitoyltransferase activity" xref: GO:0016417 "molecular_function:S-acyltransferase activity" xref: GO:0016418 "molecular_function:S-acetyltransferase activity" xref: GO:0016419 "molecular_function:S-malonyltransferase activity" xref: GO:0016420 "molecular_function:malonyltransferase activity" xref: GO:0016454 "molecular_function:C-palmitoyltransferase activity" xref: GO:0016747 "molecular_function:transferase activity, transferring acyl groups other than amino-acyl groups" xref: GO:0016748 "molecular_function:succinyltransferase activity" xref: GO:0016749 "molecular_function:N-succinyltransferase activity" xref: GO:0016750 "molecular_function:O-succinyltransferase activity" xref: GO:0016751 "molecular_function:S-succinyltransferase activity" xref: GO:0016752 "molecular_function:sinapoyltransferase activity" xref: GO:0016753 "molecular_function:O-sinapoyltransferase activity" xref: GO:0018030 "molecular_function:peptidyl-lysine N6-myristoyltransferase activity" xref: GO:0018031 "molecular_function:peptidyl-lysine N6-palmitoyltransferase activity" xref: GO:0018711 "molecular_function:benzoyl acetate-CoA thiolase activity" xref: GO:0018712 "molecular_function:3-hydroxybutyryl-CoA thiolase activity" xref: GO:0018713 "molecular_function:3-ketopimelyl-CoA thiolase activity" xref: GO:0019105 "molecular_function:N-palmitoyltransferase activity" xref: GO:0019107 "molecular_function:myristoyltransferase activity" xref: GO:0019186 "molecular_function:acyl-CoA N-acyltransferase activity" xref: GO:0019705 "molecular_function:protein-cysteine S-myristoyltransferase activity" xref: GO:0019707 "molecular_function:protein-cysteine S-acyltransferase activity" xref: GO:0030523 "molecular_function:dihydrolipoamide S-acyltransferase activity" xref: GO:0032216 "molecular_function:glucosaminyl-phosphotidylinositol O-acyltransferase activity" xref: GO:0034737 "molecular_function:ergosterol O-acyltransferase activity" xref: GO:0034738 "molecular_function:lanosterol O-acyltransferase activity" xref: GO:0034848 "molecular_function:naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity" xref: GO:0034851 "molecular_function:2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity" xref: GO:0034915 "molecular_function:2-methylhexanoyl-CoA C-acetyltransferase activity" xref: GO:0034919 "molecular_function:butyryl-CoA 2-C-propionyltransferase activity" xref: GO:0034945 "molecular_function:2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity" xref: GO:0043741 "molecular_function:L-2-aminoadipate N-acetyltransferase activity" xref: GO:0043764 "molecular_function:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity" xref: GO:0043806 "molecular_function:keto acid formate lyase activity" xref: GO:0043849 "molecular_function:Ras palmitoyltransferase activity" xref: GO:0043875 "molecular_function:2-ketobutyrate formate-lyase activity" xref: GO:0046941 "molecular_function:azetidine-2-carboxylic acid acetyltransferase activity" xref: GO:0052858 "molecular_function:peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor" xref: GO:0090595 "molecular_function:acetyl-CoA:L-lysine N6-acetyltransferase" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00512 ! benzoyl-CoA relationship: has_input_compound UPa:UPC00512 {cardinality="1", is_alternate="False", is_primary="False"} ! benzoyl-CoA relationship: has_input_compound UPa:UPC16524 {cardinality="1", is_alternate="False", is_primary="True"} ! N-(3'R)-debenzoyltaxol relationship: has_input_compound UPa:UPC16524 ! N-(3'R)-debenzoyltaxol relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC07394 ! taxol relationship: has_output_compound UPa:UPC07394 {cardinality="1", is_alternate="False", is_primary="True"} ! taxol relationship: part_of UPa:ULS00408 {cardinality="1", order="3"} ! taxol from baccatin III relationship: part_of UPa:ULS00408 ! taxol from baccatin III [Term] id: UPa:UER00054 name: 2-oxobutanoate from L-threonine: step 1/1 namespace: enzymatic_reaction def: "1 L-threonine => 1 2-oxobutanoate + 1 NH(3)." [] xref: EC:4.3.1.19 xref: GO:0004794 "molecular_function:L-threonine ammonia-lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00188 ! L-threonine relationship: has_input_compound UPa:UPC00188 {cardinality="1", is_alternate="False", is_primary="True"} ! L-threonine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00109 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00109 ! 2-oxobutanoate relationship: part_of UPa:ULS00018 ! 2-oxobutanoate from L-threonine relationship: part_of UPa:ULS00018 {cardinality="1", order="1"} ! 2-oxobutanoate from L-threonine [Term] id: UPa:UER00055 name: L-isoleucine from 2-oxobutanoate: step 1/4 namespace: enzymatic_reaction def: "1 2-hydroxyethyl-ThPP + 1 2-oxobutanoate => 1 (S)-2-acetyl-2-hydroxybutanoic acid + 1 thiamine diphosphate." [] xref: EC:2.2.1.6 xref: GO:0003984 "molecular_function:acetolactate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00109 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxobutanoate relationship: has_input_compound UPa:UPC00109 ! 2-oxobutanoate relationship: has_input_compound UPa:UPC05125 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-hydroxyethyl-ThPP relationship: has_input_compound UPa:UPC05125 ! 2-hydroxyethyl-ThPP relationship: has_output_compound UPa:UPC00068 ! thiamine diphosphate relationship: has_output_compound UPa:UPC00068 {cardinality="1", is_alternate="False", is_primary="False"} ! thiamine diphosphate relationship: has_output_compound UPa:UPC06006 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetyl-2-hydroxybutanoic acid relationship: has_output_compound UPa:UPC06006 ! (S)-2-acetyl-2-hydroxybutanoic acid relationship: part_of UPa:ULS00020 ! L-isoleucine from 2-oxobutanoate relationship: part_of UPa:ULS00020 {cardinality="1", order="1"} ! L-isoleucine from 2-oxobutanoate [Term] id: UPa:UER00056 name: L-isoleucine from 2-oxobutanoate: step 2/4 namespace: enzymatic_reaction def: "1 (S)-2-acetyl-2-hydroxybutanoic acid + 1 H(+) + 1 NADPH => 1 (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid + 1 NADP(+)." [] xref: EC:1.1.1.86 xref: GO:0004455 "molecular_function:ketol-acid reductoisomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC06006 ! (S)-2-acetyl-2-hydroxybutanoic acid relationship: has_input_compound UPa:UPC06006 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetyl-2-hydroxybutanoic acid relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC06007 {cardinality="1", is_alternate="False", is_primary="True"} ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid relationship: has_output_compound UPa:UPC06007 ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid relationship: part_of UPa:ULS00020 ! L-isoleucine from 2-oxobutanoate relationship: part_of UPa:ULS00020 {cardinality="1", order="2"} ! L-isoleucine from 2-oxobutanoate [Term] id: UPa:UER00057 name: L-isoleucine from 2-oxobutanoate: step 3/4 namespace: enzymatic_reaction def: "1 (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid => 1 (S)-3-methyl-2-oxopentanoate + 1 H(2)O." [] xref: EC:4.2.1.9 xref: GO:0004160 "molecular_function:dihydroxy-acid dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC06007 ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid relationship: has_input_compound UPa:UPC06007 {cardinality="1", is_alternate="False", is_primary="True"} ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00671 ! (S)-3-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00671 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3-methyl-2-oxopentanoate relationship: part_of UPa:ULS00020 ! L-isoleucine from 2-oxobutanoate relationship: part_of UPa:ULS00020 {cardinality="1", order="3"} ! L-isoleucine from 2-oxobutanoate [Term] id: UPa:UER00058 name: L-isoleucine from 2-oxobutanoate: step 4/4 namespace: enzymatic_reaction def: "1 (S)-3-methyl-2-oxopentanoate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-isoleucine." [] xref: EC:2.6.1.42 xref: GO:0004084 "molecular_function:branched-chain-amino-acid transaminase activity" xref: GO:0052654 "molecular_function:L-leucine transaminase activity" xref: GO:0052655 "molecular_function:L-valine transaminase activity" xref: GO:0052656 "molecular_function:L-isoleucine transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00671 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3-methyl-2-oxopentanoate relationship: has_input_compound UPa:UPC00671 ! (S)-3-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00407 ! L-isoleucine relationship: has_output_compound UPa:UPC00407 {cardinality="1", is_alternate="False", is_primary="True"} ! L-isoleucine relationship: part_of UPa:ULS00020 ! L-isoleucine from 2-oxobutanoate relationship: part_of UPa:ULS00020 {cardinality="1", order="4"} ! L-isoleucine from 2-oxobutanoate [Term] id: UPa:UER00059 name: L-valine from pyruvate: step 1/4 namespace: enzymatic_reaction def: "1 pyruvate => 1 (S)-2-acetolactate + 1 CO(2) + 1 thiamine diphosphate." [] xref: EC:2.2.1.6 xref: GO:0003984 "molecular_function:acetolactate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00068 ! thiamine diphosphate relationship: has_output_compound UPa:UPC00068 {cardinality="1", is_alternate="False", is_primary="False"} ! thiamine diphosphate relationship: has_output_compound UPa:UPC06010 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC06010 ! (S)-2-acetolactate relationship: part_of UPa:ULS00021 ! L-valine from pyruvate relationship: part_of UPa:ULS00021 {cardinality="1", order="1"} ! L-valine from pyruvate [Term] id: UPa:UER00060 name: L-valine from pyruvate: step 2/4 namespace: enzymatic_reaction def: "1 (S)-2-acetolactate + 1 H(+) + 1 NADPH => 1 (R)-2,3-dihydroxy-3-methylbutanoate + 1 NADP(+)." [] xref: EC:1.1.1.86 xref: GO:0004455 "molecular_function:ketol-acid reductoisomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC06010 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetolactate relationship: has_input_compound UPa:UPC06010 ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC04272 ! (R)-2,3-dihydroxy-3-methylbutanoate relationship: has_output_compound UPa:UPC04272 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-2,3-dihydroxy-3-methylbutanoate relationship: part_of UPa:ULS00021 {cardinality="1", order="2"} ! L-valine from pyruvate relationship: part_of UPa:ULS00021 ! L-valine from pyruvate [Term] id: UPa:UER00061 name: L-valine from pyruvate: step 3/4 namespace: enzymatic_reaction def: "1 (R)-2,3-dihydroxy-3-methylbutanoate => 1 3-methyl-2-oxobutanoate + 1 H(2)O." [] xref: EC:4.2.1.9 xref: GO:0004160 "molecular_function:dihydroxy-acid dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04272 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-2,3-dihydroxy-3-methylbutanoate relationship: has_input_compound UPa:UPC04272 ! (R)-2,3-dihydroxy-3-methylbutanoate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate relationship: has_output_compound UPa:UPC00141 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methyl-2-oxobutanoate relationship: part_of UPa:ULS00021 ! L-valine from pyruvate relationship: part_of UPa:ULS00021 {cardinality="1", order="3"} ! L-valine from pyruvate [Term] id: UPa:UER00062 name: L-valine from pyruvate: step 4/4 namespace: enzymatic_reaction def: "1 3-methyl-2-oxobutanoate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-valine." [] xref: EC:2.6.1.42 xref: GO:0004084 "molecular_function:branched-chain-amino-acid transaminase activity" xref: GO:0052654 "molecular_function:L-leucine transaminase activity" xref: GO:0052655 "molecular_function:L-valine transaminase activity" xref: GO:0052656 "molecular_function:L-isoleucine transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate relationship: has_input_compound UPa:UPC00141 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methyl-2-oxobutanoate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00183 ! L-valine relationship: has_output_compound UPa:UPC00183 {cardinality="1", is_alternate="False", is_primary="True"} ! L-valine relationship: part_of UPa:ULS00021 ! L-valine from pyruvate relationship: part_of UPa:ULS00021 {cardinality="1", order="4"} ! L-valine from pyruvate [Term] id: UPa:UER00063 name: L-threonine from L-aspartate: step 3/5 namespace: enzymatic_reaction def: "H(+) + L-aspartate 4-semialdehyde + [NADH or NADPH] => L-homoserine + [NAD(+) or NADP(+)]." [] xref: EC:1.1.1.3 xref: GO:0004412 "molecular_function:homoserine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00949 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00950 ! None relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00263 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homoserine relationship: has_output_compound UPa:UPC00263 ! L-homoserine relationship: part_of UPa:ULS00022 {cardinality="1", order="3"} ! L-threonine from L-aspartate relationship: part_of UPa:ULS00022 ! L-threonine from L-aspartate [Term] id: UPa:UER00064 name: L-threonine from L-aspartate: step 4/5 namespace: enzymatic_reaction def: "1 ATP + 1 L-homoserine => 1 ADP + 1 O-phospho-L-homoserine." [] xref: EC:2.7.1.39 xref: GO:0004413 "molecular_function:homoserine kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00263 ! L-homoserine relationship: has_input_compound UPa:UPC00263 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homoserine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC01102 ! O-phospho-L-homoserine relationship: has_output_compound UPa:UPC01102 {cardinality="1", is_alternate="False", is_primary="True"} ! O-phospho-L-homoserine relationship: part_of UPa:ULS00022 {cardinality="1", order="4"} ! L-threonine from L-aspartate relationship: part_of UPa:ULS00022 ! L-threonine from L-aspartate [Term] id: UPa:UER00065 name: L-threonine from L-aspartate: step 5/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 O-phospho-L-homoserine => 1 L-threonine + 1 phosphate." [] xref: EC:4.2.3.1 xref: GO:0004795 "molecular_function:threonine synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC01102 ! O-phospho-L-homoserine relationship: has_input_compound UPa:UPC01102 {cardinality="1", is_alternate="False", is_primary="True"} ! O-phospho-L-homoserine relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00188 ! L-threonine relationship: has_output_compound UPa:UPC00188 {cardinality="1", is_alternate="False", is_primary="True"} ! L-threonine relationship: part_of UPa:ULS00022 {cardinality="1", order="5"} ! L-threonine from L-aspartate relationship: part_of UPa:ULS00022 ! L-threonine from L-aspartate [Term] id: UPa:UER00066 name: 2-oxobutanoate from pyruvate: step 1/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 acetyl-CoA + 1 pyruvate => 1 (R)-citramalate + 1 CoA." [] xref: EC:2.3.1.182 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC02612 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-citramalate relationship: has_output_compound UPa:UPC02612 ! (R)-citramalate relationship: part_of UPa:ULS00019 {cardinality="1", order="1"} ! 2-oxobutanoate from pyruvate relationship: part_of UPa:ULS00019 ! 2-oxobutanoate from pyruvate [Term] id: UPa:UER00067 name: 2-oxobutanoate from pyruvate: step 2/3 namespace: enzymatic_reaction def: "1 (R)-citramalate => 1 D-erythro-3-methylmalic acid." [] xref: EC:4.2.1.35 xref: GO:0047508 "molecular_function:(R)-2-methylmalate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC02612 ! (R)-citramalate relationship: has_input_compound UPa:UPC02612 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-citramalate relationship: has_output_compound UPa:UPC06032 ! D-erythro-3-methylmalic acid relationship: has_output_compound UPa:UPC06032 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythro-3-methylmalic acid relationship: part_of UPa:ULS00019 {cardinality="1", order="2"} ! 2-oxobutanoate from pyruvate relationship: part_of UPa:ULS00019 ! 2-oxobutanoate from pyruvate [Term] id: UPa:UER00069 name: 2-oxobutanoate from pyruvate: step 3/3 namespace: enzymatic_reaction def: "1 D-erythro-3-methylmalic acid + 1 NAD(+) => 1 2-oxobutanoate + 1 CO(2) + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.n5 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC06032 ! D-erythro-3-methylmalic acid relationship: has_input_compound UPa:UPC06032 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythro-3-methylmalic acid relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00109 ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00109 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxobutanoate relationship: part_of UPa:ULS00019 {cardinality="1", order="3"} ! 2-oxobutanoate from pyruvate relationship: part_of UPa:ULS00019 ! 2-oxobutanoate from pyruvate [Term] id: UPa:UER00070 name: L-leucine from 3-methyl-2-oxobutanoate: step 1/4 namespace: enzymatic_reaction def: "1 3-methyl-2-oxobutanoate + 1 H(2)O + 1 acetyl-CoA => 1 (2S)-2-isopropylmalate + 1 CoA." [] xref: EC:2.3.3.13 xref: GO:0003852 "molecular_function:2-isopropylmalate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00141 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methyl-2-oxobutanoate relationship: has_input_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC02504 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S)-2-isopropylmalate relationship: has_output_compound UPa:UPC02504 ! (2S)-2-isopropylmalate relationship: part_of UPa:ULS00023 ! L-leucine from 3-methyl-2-oxobutanoate relationship: part_of UPa:ULS00023 {cardinality="1", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate [Term] id: UPa:UER00071 name: L-leucine from 3-methyl-2-oxobutanoate: step 2/4 namespace: enzymatic_reaction def: "1 (2S)-2-isopropylmalate => 1 (2R,3S)-3-isopropylmalate." [] xref: EC:4.2.1.33 xref: GO:0003861 "molecular_function:3-isopropylmalate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC02504 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S)-2-isopropylmalate relationship: has_input_compound UPa:UPC02504 ! (2S)-2-isopropylmalate relationship: has_output_compound UPa:UPC04411 ! (2R,3S)-3-isopropylmalate relationship: has_output_compound UPa:UPC04411 {cardinality="1", is_alternate="False", is_primary="True"} ! (2R,3S)-3-isopropylmalate relationship: part_of UPa:ULS00023 ! L-leucine from 3-methyl-2-oxobutanoate relationship: part_of UPa:ULS00023 {cardinality="1", order="2"} ! L-leucine from 3-methyl-2-oxobutanoate [Term] id: UPa:UER00072 name: L-leucine from 3-methyl-2-oxobutanoate: step 3/4 namespace: enzymatic_reaction def: "1 (2R,3S)-3-isopropylmalate + 1 NAD(+) => 1 4-methyl-2-oxopentanoate + 1 CO(2) + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.85 xref: GO:0003862 "molecular_function:3-isopropylmalate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC04411 ! (2R,3S)-3-isopropylmalate relationship: has_input_compound UPa:UPC04411 {cardinality="1", is_alternate="False", is_primary="True"} ! (2R,3S)-3-isopropylmalate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00233 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-2-oxopentanoate relationship: part_of UPa:ULS00023 {cardinality="1", order="3"} ! L-leucine from 3-methyl-2-oxobutanoate relationship: part_of UPa:ULS00023 ! L-leucine from 3-methyl-2-oxobutanoate [Term] id: UPa:UER00073 name: L-leucine from 3-methyl-2-oxobutanoate: step 4/4 namespace: enzymatic_reaction def: "1 4-methyl-2-oxopentanoate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-leucine." [] xref: EC:2.6.1.42 xref: GO:0004084 "molecular_function:branched-chain-amino-acid transaminase activity" xref: GO:0052654 "molecular_function:L-leucine transaminase activity" xref: GO:0052655 "molecular_function:L-valine transaminase activity" xref: GO:0052656 "molecular_function:L-isoleucine transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00233 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-2-oxopentanoate relationship: has_input_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00123 {cardinality="1", is_alternate="False", is_primary="True"} ! L-leucine relationship: has_output_compound UPa:UPC00123 ! L-leucine relationship: part_of UPa:ULS00023 {cardinality="1", order="4"} ! L-leucine from 3-methyl-2-oxobutanoate relationship: part_of UPa:ULS00023 ! L-leucine from 3-methyl-2-oxobutanoate [Term] id: UPa:UER00074 name: O-acetyl-L-homoserine from L-homoserine: step 1/1 namespace: enzymatic_reaction def: "1 L-homoserine + 1 acetyl-CoA => 1 CoA + 1 O-acetyl-L-homoserine." [] xref: EC:2.3.1.31 xref: GO:0004414 "molecular_function:homoserine O-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00263 ! L-homoserine relationship: has_input_compound UPa:UPC00263 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homoserine relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC01077 ! O-acetyl-L-homoserine relationship: has_output_compound UPa:UPC01077 {cardinality="1", is_alternate="False", is_primary="True"} ! O-acetyl-L-homoserine relationship: part_of UPa:ULS00026 ! O-acetyl-L-homoserine from L-homoserine relationship: part_of UPa:ULS00026 {cardinality="1", order="1"} ! O-acetyl-L-homoserine from L-homoserine [Term] id: UPa:UER00075 name: O-succinyl-L-homoserine from L-homoserine: step 1/1 namespace: enzymatic_reaction def: "1 L-homoserine + 1 succinyl-CoA => 1 CoA + 1 O-succinyl-L-homoserine." [] xref: EC:2.3.1.46 xref: GO:0008899 "molecular_function:homoserine O-succinyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="False"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00263 ! L-homoserine relationship: has_input_compound UPa:UPC00263 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homoserine relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC01118 {cardinality="1", is_alternate="False", is_primary="True"} ! O-succinyl-L-homoserine relationship: has_output_compound UPa:UPC01118 ! O-succinyl-L-homoserine relationship: part_of UPa:ULS00027 ! O-succinyl-L-homoserine from L-homoserine relationship: part_of UPa:ULS00027 {cardinality="1", order="1"} ! O-succinyl-L-homoserine from L-homoserine [Term] id: UPa:UER00076 name: L-homocysteine from S-adenosyl-L-homocysteine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 S-adenosyl-L-homocysteine => 1 L-homocysteine + 1 adenosine." [] xref: EC:3.3.1.1 xref: GO:0004013 "molecular_function:adenosylhomocysteinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="True"} ! S-adenosyl-L-homocysteine relationship: has_input_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_output_compound UPa:UPC00155 ! L-homocysteine relationship: has_output_compound UPa:UPC00212 ! adenosine relationship: has_output_compound UPa:UPC00212 {cardinality="1", is_alternate="False", is_primary="False"} ! adenosine relationship: part_of UPa:ULS00028 ! L-homocysteine from S-adenosyl-L-homocysteine relationship: part_of UPa:ULS00028 {cardinality="1", order="1"} ! L-homocysteine from S-adenosyl-L-homocysteine [Term] id: UPa:UER00077 name: L-cystathionine from O-succinyl-L-homoserine: step 1/1 namespace: enzymatic_reaction def: "1 L-cysteine + 1 O-succinyl-L-homoserine => 1 L-cystathionine + 1 succinate." [] xref: EC:2.5.1.48 xref: GO:0003962 "molecular_function:cystathionine gamma-synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="False"} ! L-cysteine relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC01118 ! O-succinyl-L-homoserine relationship: has_input_compound UPa:UPC01118 {cardinality="1", is_alternate="False", is_primary="True"} ! O-succinyl-L-homoserine relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC02291 ! L-cystathionine relationship: has_output_compound UPa:UPC02291 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cystathionine relationship: part_of UPa:ULS00029 ! L-cystathionine from O-succinyl-L-homoserine relationship: part_of UPa:ULS00029 {cardinality="1", order="1"} ! L-cystathionine from O-succinyl-L-homoserine [Term] id: UPa:UER00078 name: L-homocysteine from L-cystathionine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-cystathionine => 1 L-homocysteine + 1 NH(3) + 1 pyruvate." [] xref: EC:4.4.1.8 xref: GO:0004121 "molecular_function:cystathionine beta-lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC02291 ! L-cystathionine relationship: has_input_compound UPa:UPC02291 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cystathionine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_output_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_output_compound UPa:UPC00155 ! L-homocysteine relationship: part_of UPa:ULS00030 ! L-homocysteine from L-cystathionine relationship: part_of UPa:ULS00030 {cardinality="1", order="1"} ! L-homocysteine from L-cystathionine [Term] id: UPa:UER00079 name: L-homocysteine from O-acetyl-L-homoserine: step 1/1 namespace: enzymatic_reaction def: "1 O-acetyl-L-homoserine + 1 hydrogen sulfide => 1 L-homocysteine + 1 acetate." [] xref: EC:2.5.1.49 xref: GO:0003961 "molecular_function:O-acetylhomoserine aminocarboxypropyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_input_compound UPa:UPC00283 {cardinality="1", is_alternate="False", is_primary="False"} ! hydrogen sulfide relationship: has_input_compound UPa:UPC01077 ! O-acetyl-L-homoserine relationship: has_input_compound UPa:UPC01077 {cardinality="1", is_alternate="False", is_primary="True"} ! O-acetyl-L-homoserine relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_output_compound UPa:UPC00155 ! L-homocysteine relationship: part_of UPa:ULS00031 ! L-homocysteine from O-acetyl-L-homoserine relationship: part_of UPa:ULS00031 {cardinality="1", order="1"} ! L-homocysteine from O-acetyl-L-homoserine [Term] id: UPa:UER00080 name: S-adenosyl-L-methionine from L-methionine: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 H(2)O + 1 L-methionine => 1 S-adenosyl-L-methionine + 1 diphosphate + 1 phosphate." [] xref: EC:2.5.1.6 xref: GO:0004478 "molecular_function:methionine adenosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00073 ! L-methionine relationship: has_input_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="True"} ! L-methionine relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="True"} ! S-adenosyl-L-methionine relationship: has_output_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: part_of UPa:ULS00032 {cardinality="1", order="1"} ! S-adenosyl-L-methionine from L-methionine relationship: part_of UPa:ULS00032 ! S-adenosyl-L-methionine from L-methionine [Term] id: UPa:UER00081 name: L-methionine from L-homocysteine (MetH route): step 1/1 namespace: enzymatic_reaction def: "1 5-methyl-THF + 1 L-homocysteine => 1 5,6,7,8-tetrahydrofolate + 1 L-methionine." [] xref: EC:2.1.1.13 xref: GO:0008705 "molecular_function:methionine synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_input_compound UPa:UPC00440 ! 5-methyl-THF relationship: has_input_compound UPa:UPC00440 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-methyl-THF relationship: has_output_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="True"} ! L-methionine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:ULS00033 {cardinality="1", order="1"} ! L-methionine from L-homocysteine (MetH route) relationship: part_of UPa:ULS00033 ! L-methionine from L-homocysteine (MetH route) [Term] id: UPa:UER00082 name: L-methionine from L-homocysteine (MetE route): step 1/1 namespace: enzymatic_reaction def: "1 5-methyltetrahydropteroyltri-L-glutamate + 1 L-homocysteine => 1 L-methionine + 1 tetrahydropteroyltri-L-glutamate." [] xref: EC:2.1.1.14 xref: GO:0003871 "molecular_function:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_input_compound UPa:UPC04489 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-methyltetrahydropteroyltri-L-glutamate relationship: has_input_compound UPa:UPC04489 ! 5-methyltetrahydropteroyltri-L-glutamate relationship: has_output_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="True"} ! L-methionine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC04144 ! tetrahydropteroyltri-L-glutamate relationship: has_output_compound UPa:UPC04144 {cardinality="1", is_alternate="False", is_primary="False"} ! tetrahydropteroyltri-L-glutamate relationship: part_of UPa:ULS00034 ! L-methionine from L-homocysteine (MetE route) relationship: part_of UPa:ULS00034 {cardinality="1", order="1"} ! L-methionine from L-homocysteine (MetE route) [Term] id: UPa:UER00083 name: L-methionine from L-homocysteine (BhmT route): step 1/1 namespace: enzymatic_reaction def: "1 L-homocysteine + 1 betaine => 1 L-methionine + 1 N,N-dimethylglycine." [] xref: EC:2.1.1.5 xref: GO:0047150 "molecular_function:betaine-homocysteine S-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_input_compound UPa:UPC00719 ! betaine relationship: has_input_compound UPa:UPC00719 {cardinality="1", is_alternate="False", is_primary="False"} ! betaine relationship: has_output_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="True"} ! L-methionine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC01026 {cardinality="1", is_alternate="False", is_primary="False"} ! N,N-dimethylglycine relationship: has_output_compound UPa:UPC01026 ! N,N-dimethylglycine relationship: part_of UPa:ULS00035 ! L-methionine from L-homocysteine (BhmT route) relationship: part_of UPa:ULS00035 {cardinality="1", order="1"} ! L-methionine from L-homocysteine (BhmT route) [Term] id: UPa:UER00084 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7 namespace: enzymatic_reaction def: "1 D-erythrose 4-phosphate + 1 H(2)O + 1 phosphoenolpyruvate => 1 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + 1 phosphate." [] xref: EC:2.5.1.54 xref: GO:0003849 "molecular_function:3-deoxy-7-phosphoheptulonate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00074 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00279 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythrose 4-phosphate relationship: has_input_compound UPa:UPC00279 ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC04691 {cardinality="1", is_alternate="False", is_primary="True"} ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate relationship: has_output_compound UPa:UPC04691 ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate relationship: part_of UPa:ULS00036 {cardinality="1", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate relationship: part_of UPa:ULS00036 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00085 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7 namespace: enzymatic_reaction def: "1 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate => 1 3-dehydroquinate + 1 phosphate." [] xref: EC:4.2.3.4 xref: GO:0003856 "molecular_function:3-dehydroquinate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04691 ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate relationship: has_input_compound UPa:UPC04691 {cardinality="1", is_alternate="False", is_primary="True"} ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00944 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00944 ! 3-dehydroquinate relationship: part_of UPa:ULS00036 {cardinality="1", order="2"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate relationship: part_of UPa:ULS00036 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00086 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7 namespace: enzymatic_reaction def: "1 3-dehydroquinate => 1 3-dehydroshikimate + 1 H(2)O." [] xref: EC:4.2.1.10 xref: GO:0003855 "molecular_function:3-dehydroquinate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00944 ! 3-dehydroquinate relationship: has_input_compound UPa:UPC00944 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC02637 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroshikimate relationship: has_output_compound UPa:UPC02637 ! 3-dehydroshikimate relationship: part_of UPa:ULS00036 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate relationship: part_of UPa:ULS00036 {cardinality="1", order="3"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00087 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7 namespace: enzymatic_reaction def: "1 3-dehydroshikimate + 1 H(+) + 1 NADPH => 1 NADP(+) + 1 shikimate." [] xref: EC:1.1.1.25 xref: EC:1.1.1.282 xref: GO:0004764 "molecular_function:shikimate 3-dehydrogenase (NADP+) activity" xref: GO:0030266 "molecular_function:quinate 3-dehydrogenase (NAD+) activity" xref: GO:0052733 "molecular_function:quinate 3-dehydrogenase (NADP+) activity" xref: GO:0052734 "molecular_function:shikimate 3-dehydrogenase (NAD+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC02637 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroshikimate relationship: has_input_compound UPa:UPC02637 ! 3-dehydroshikimate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00493 {cardinality="1", is_alternate="False", is_primary="True"} ! shikimate relationship: has_output_compound UPa:UPC00493 ! shikimate relationship: part_of UPa:ULS00036 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate relationship: part_of UPa:ULS00036 {cardinality="1", order="4"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00088 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7 namespace: enzymatic_reaction def: "1 ATP + 1 shikimate => 1 3-phosphoshikimate + 1 ADP." [] xref: EC:2.7.1.71 xref: GO:0004765 "molecular_function:shikimate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00493 {cardinality="1", is_alternate="False", is_primary="True"} ! shikimate relationship: has_input_compound UPa:UPC00493 ! shikimate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC03175 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phosphoshikimate relationship: has_output_compound UPa:UPC03175 ! 3-phosphoshikimate relationship: part_of UPa:ULS00036 {cardinality="1", order="5"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate relationship: part_of UPa:ULS00036 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00089 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7 namespace: enzymatic_reaction def: "1 3-phosphoshikimate + 1 phosphoenolpyruvate => 1 5-O-(1-carboxyvinyl)-3-phosphoshikimate + 1 phosphate." [] xref: EC:2.5.1.19 xref: GO:0003866 "molecular_function:3-phosphoshikimate 1-carboxyvinyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00074 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC03175 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phosphoshikimate relationship: has_input_compound UPa:UPC03175 ! 3-phosphoshikimate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC01269 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate relationship: has_output_compound UPa:UPC01269 ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate relationship: part_of UPa:ULS00036 {cardinality="1", order="6"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate relationship: part_of UPa:ULS00036 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00090 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7 namespace: enzymatic_reaction def: "1 5-O-(1-carboxyvinyl)-3-phosphoshikimate => 1 chorismate + 1 phosphate." [] xref: EC:4.2.3.5 xref: GO:0004107 "molecular_function:chorismate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01269 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate relationship: has_input_compound UPa:UPC01269 ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00251 ! chorismate relationship: has_output_compound UPa:UPC00251 {cardinality="1", is_alternate="False", is_primary="True"} ! chorismate relationship: part_of UPa:ULS00036 {cardinality="1", order="7"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate relationship: part_of UPa:ULS00036 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00091 name: 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1 namespace: enzymatic_reaction def: "1 D-glyceraldehyde 3-phosphate + 1 pyruvate => 1 1-deoxy-D-xylulose 5-phosphate + 1 CO(2)." [] xref: EC:2.2.1.7 xref: GO:0008661 "molecular_function:1-deoxy-D-xylulose-5-phosphate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC11437 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:ULS00040 {cardinality="1", order="1"} ! 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate relationship: part_of UPa:ULS00040 ! 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate [Term] id: UPa:UER00092 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6 namespace: enzymatic_reaction def: "1 1-deoxy-D-xylulose 5-phosphate + 1 H(+) + 1 NADPH => 1 2-C-methyl-D-erythritol 4-phosphate + 1 NADP(+)." [] xref: EC:1.1.1.267 xref: GO:0030604 "molecular_function:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC11437 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC11434 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-C-methyl-D-erythritol 4-phosphate relationship: has_output_compound UPa:UPC11434 ! 2-C-methyl-D-erythritol 4-phosphate relationship: part_of UPa:ULS00037 {cardinality="1", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:ULS00037 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00093 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6 namespace: enzymatic_reaction def: "1 2-C-methyl-D-erythritol 4-phosphate + 1 CTP => 1 4-CDP-2-C-methyl-D-erythritol + 1 diphosphate." [] xref: EC:2.7.7.60 xref: GO:0050518 "molecular_function:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00063 {cardinality="1", is_alternate="False", is_primary="False"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC11434 ! 2-C-methyl-D-erythritol 4-phosphate relationship: has_input_compound UPa:UPC11434 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-C-methyl-D-erythritol 4-phosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC11435 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-CDP-2-C-methyl-D-erythritol relationship: has_output_compound UPa:UPC11435 ! 4-CDP-2-C-methyl-D-erythritol relationship: part_of UPa:ULS00037 {cardinality="1", order="2"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:ULS00037 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00094 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6 namespace: enzymatic_reaction def: "1 4-CDP-2-C-methyl-D-erythritol + 1 ATP => 1 4-CDP-2-C-methyl-D-erythritol 2-phosphate + 1 ADP." [] xref: EC:2.7.1.148 xref: GO:0050515 "molecular_function:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC11435 ! 4-CDP-2-C-methyl-D-erythritol relationship: has_input_compound UPa:UPC11435 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-CDP-2-C-methyl-D-erythritol relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC11436 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate relationship: has_output_compound UPa:UPC11436 ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate relationship: part_of UPa:ULS00037 {cardinality="1", order="3"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:ULS00037 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00095 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6 namespace: enzymatic_reaction def: "1 4-CDP-2-C-methyl-D-erythritol 2-phosphate => 1 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + 1 CMP." [] xref: EC:4.6.1.12 xref: GO:0008685 "molecular_function:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC11436 ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate relationship: has_input_compound UPa:UPC11436 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="False"} ! CMP relationship: has_output_compound UPa:UPC11453 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate relationship: has_output_compound UPa:UPC11453 ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate relationship: part_of UPa:ULS00037 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:ULS00037 {cardinality="1", order="4"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00096 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6 namespace: enzymatic_reaction def: "1 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + 2 reduced ferredoxin => 1 (2E)-4-hydroxy-3-methylbutenyl diphosphate + 1 H(2)O + 2 oxidized ferredoxin." [] xref: EC:1.17.7.1 xref: GO:0046429 "molecular_function:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00138 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced ferredoxin relationship: has_input_compound UPa:UPC00138 ! reduced ferredoxin relationship: has_input_compound UPa:UPC11453 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate relationship: has_input_compound UPa:UPC11453 ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00139 {cardinality="1", is_alternate="False", is_primary="False"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00139 ! oxidized ferredoxin relationship: has_output_compound UPa:UPC11811 {cardinality="1", is_alternate="False", is_primary="True"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_output_compound UPa:UPC11811 ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: part_of UPa:ULS00037 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:ULS00037 {cardinality="1", order="5"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00097 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6 namespace: enzymatic_reaction def: "1 (2E)-4-hydroxy-3-methylbutenyl diphosphate + 1 H(+) + 1 NADPH => 1 H(2)O + 1 NADP(+) + 1 isopentenyl diphosphate." [] xref: EC:1.17.1.2 xref: GO:0051745 "molecular_function:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC11811 ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_input_compound UPa:UPC11811 {cardinality="1", is_alternate="False", is_primary="True"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00129 {cardinality="1", is_alternate="False", is_primary="True"} ! isopentenyl diphosphate relationship: has_output_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: part_of UPa:ULS00037 {cardinality="1", order="6"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:ULS00037 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00098 name: isopentenyl diphosphate from (R)-mevalonate: step 1/3 namespace: enzymatic_reaction def: "1 (R)-mevalonate + 1 ATP => 1 (R)-5-phosphomevalonate + 1 ADP." [] xref: EC:2.7.1.36 xref: GO:0004496 "molecular_function:mevalonate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00418 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-mevalonate relationship: has_input_compound UPa:UPC00418 ! (R)-mevalonate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC01107 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-5-phosphomevalonate relationship: has_output_compound UPa:UPC01107 ! (R)-5-phosphomevalonate relationship: part_of UPa:ULS00038 {cardinality="1", order="1"} ! isopentenyl diphosphate from (R)-mevalonate relationship: part_of UPa:ULS00038 ! isopentenyl diphosphate from (R)-mevalonate [Term] id: UPa:UER00099 name: isopentenyl diphosphate from (R)-mevalonate: step 2/3 namespace: enzymatic_reaction def: "1 (R)-5-phosphomevalonate + 1 ATP => 1 (R)-5-diphosphomevalonate + 1 ADP." [] xref: EC:2.7.4.2 xref: GO:0004631 "molecular_function:phosphomevalonate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01107 ! (R)-5-phosphomevalonate relationship: has_input_compound UPa:UPC01107 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-5-phosphomevalonate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC01143 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-5-diphosphomevalonate relationship: has_output_compound UPa:UPC01143 ! (R)-5-diphosphomevalonate relationship: part_of UPa:ULS00038 ! isopentenyl diphosphate from (R)-mevalonate relationship: part_of UPa:ULS00038 {cardinality="1", order="2"} ! isopentenyl diphosphate from (R)-mevalonate [Term] id: UPa:UER00100 name: isopentenyl diphosphate from (R)-mevalonate: step 3/3 namespace: enzymatic_reaction def: "1 (R)-5-diphosphomevalonate + 1 ATP => 1 ADP + 1 CO(2) + 1 isopentenyl diphosphate + 1 phosphate." [] xref: EC:4.1.1.33 xref: GO:0004163 "molecular_function:diphosphomevalonate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC01143 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-5-diphosphomevalonate relationship: has_input_compound UPa:UPC01143 ! (R)-5-diphosphomevalonate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00129 {cardinality="1", is_alternate="False", is_primary="True"} ! isopentenyl diphosphate relationship: has_output_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: part_of UPa:ULS00038 {cardinality="1", order="3"} ! isopentenyl diphosphate from (R)-mevalonate relationship: part_of UPa:ULS00038 ! isopentenyl diphosphate from (R)-mevalonate [Term] id: UPa:UER00101 name: (R)-mevalonate from acetyl-CoA: step 1/3 namespace: enzymatic_reaction def: "2 acetyl-CoA => 1 CoA + 1 acetoacetyl-CoA." [] xref: EC:2.3.1.9 xref: GO:0003985 "molecular_function:acetyl-CoA C-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00332 ! acetoacetyl-CoA relationship: has_output_compound UPa:UPC00332 {cardinality="1", is_alternate="False", is_primary="True"} ! acetoacetyl-CoA relationship: part_of UPa:ULS00039 {cardinality="1", order="1"} ! (R)-mevalonate from acetyl-CoA relationship: part_of UPa:ULS00039 ! (R)-mevalonate from acetyl-CoA [Term] id: UPa:UER00102 name: (R)-mevalonate from acetyl-CoA: step 2/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 acetoacetyl-CoA + 1 acetyl-CoA => 1 (S)-3-hydroxy-3-methylglutaryl-CoA + 1 CoA." [] xref: EC:2.3.3.10 xref: GO:0004421 "molecular_function:hydroxymethylglutaryl-CoA synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00332 ! acetoacetyl-CoA relationship: has_input_compound UPa:UPC00332 {cardinality="1", is_alternate="False", is_primary="True"} ! acetoacetyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00356 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: part_of UPa:ULS00039 ! (R)-mevalonate from acetyl-CoA relationship: part_of UPa:ULS00039 {cardinality="1", order="2"} ! (R)-mevalonate from acetyl-CoA [Term] id: UPa:UER00103 name: (R)-mevalonate from acetyl-CoA: step 3/3 namespace: enzymatic_reaction def: "1 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH => 1 (R)-mevalonate + 1 CoA + 2 NADP(+)." [] xref: EC:1.1.1.34 xref: GO:0004420 "molecular_function:hydroxymethylglutaryl-CoA reductase (NADPH) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_input_compound UPa:UPC00356 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00418 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-mevalonate relationship: has_output_compound UPa:UPC00418 ! (R)-mevalonate relationship: part_of UPa:ULS00039 {cardinality="1", order="3"} ! (R)-mevalonate from acetyl-CoA relationship: part_of UPa:ULS00039 ! (R)-mevalonate from acetyl-CoA [Term] id: UPa:UER00104 name: dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 isopentenyl diphosphate => 1 dimethylallyl diphosphate." [] xref: EC:5.3.3.2 xref: GO:0004452 "molecular_function:isopentenyl-diphosphate delta-isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00129 {cardinality="1", is_alternate="False", is_primary="True"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_output_compound UPa:UPC00235 ! dimethylallyl diphosphate relationship: has_output_compound UPa:UPC00235 {cardinality="1", is_alternate="False", is_primary="True"} ! dimethylallyl diphosphate relationship: part_of UPa:ULS00041 ! dimethylallyl diphosphate from isopentenyl diphosphate relationship: part_of UPa:ULS00041 {cardinality="1", order="1"} ! dimethylallyl diphosphate from isopentenyl diphosphate [Term] id: UPa:UER00105 name: dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 (2E)-4-hydroxy-3-methylbutenyl diphosphate + 1 H(+) + 1 NADPH => 1 H(2)O + 1 NADP(+) + 1 dimethylallyl diphosphate." [] xref: EC:1.17.1.2 xref: GO:0051745 "molecular_function:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC11811 ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_input_compound UPa:UPC11811 {cardinality="1", is_alternate="False", is_primary="True"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00235 ! dimethylallyl diphosphate relationship: has_output_compound UPa:UPC00235 {cardinality="1", is_alternate="False", is_primary="True"} ! dimethylallyl diphosphate relationship: part_of UPa:ULS00042 ! dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: part_of UPa:ULS00042 {cardinality="1", order="1"} ! dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate [Term] id: UPa:UER00106 name: N(2)-acetyl-L-ornithine from L-glutamate: step 1/4 namespace: enzymatic_reaction def: "1 L-glutamate + 1 acetyl-CoA => 1 CoA + 1 N-acetyl-L-glutamate." [] xref: EC:2.3.1.1 xref: GO:0004042 "molecular_function:acetyl-CoA:L-glutamate N-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00624 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamate relationship: has_output_compound UPa:UPC00624 ! N-acetyl-L-glutamate relationship: part_of UPa:ULS00043 {cardinality="1", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate relationship: part_of UPa:ULS00043 ! N(2)-acetyl-L-ornithine from L-glutamate [Term] id: UPa:UER00107 name: N(2)-acetyl-L-ornithine from L-glutamate: step 2/4 namespace: enzymatic_reaction def: "1 ATP + 1 N-acetyl-L-glutamate => 1 ADP + 1 N-acetyl-L-glutamyl 5-phosphate." [] xref: EC:2.7.2.8 xref: GO:0003991 "molecular_function:acetylglutamate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00624 ! N-acetyl-L-glutamate relationship: has_input_compound UPa:UPC00624 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC04133 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamyl 5-phosphate relationship: has_output_compound UPa:UPC04133 ! N-acetyl-L-glutamyl 5-phosphate relationship: part_of UPa:ULS00043 {cardinality="1", order="2"} ! N(2)-acetyl-L-ornithine from L-glutamate relationship: part_of UPa:ULS00043 ! N(2)-acetyl-L-ornithine from L-glutamate [Term] id: UPa:UER00108 name: N(2)-acetyl-L-ornithine from L-glutamate: step 3/4 namespace: enzymatic_reaction def: "1 H(+) + 1 N-acetyl-L-glutamyl 5-phosphate + 1 NADPH => 1 N-acetyl-L-glutamate 5-semialdehyde + 1 NADP(+) + 1 phosphate." [] xref: EC:1.2.1.38 xref: GO:0003942 "molecular_function:N-acetyl-gamma-glutamyl-phosphate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC04133 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamyl 5-phosphate relationship: has_input_compound UPa:UPC04133 ! N-acetyl-L-glutamyl 5-phosphate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC01250 ! N-acetyl-L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC01250 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamate 5-semialdehyde relationship: part_of UPa:ULS00043 ! N(2)-acetyl-L-ornithine from L-glutamate relationship: part_of UPa:ULS00043 {cardinality="1", order="3"} ! N(2)-acetyl-L-ornithine from L-glutamate [Term] id: UPa:UER00109 name: N(2)-acetyl-L-ornithine from L-glutamate: step 4/4 namespace: enzymatic_reaction def: "1 L-glutamate + 1 N-acetyl-L-glutamate 5-semialdehyde => 1 2-oxoglutarate + 1 N(2)-acetyl-L-ornithine." [] xref: EC:2.6.1.11 xref: GO:0003992 "molecular_function:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC01250 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamate 5-semialdehyde relationship: has_input_compound UPa:UPC01250 ! N-acetyl-L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00437 ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00437 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-acetyl-L-ornithine relationship: part_of UPa:ULS00043 ! N(2)-acetyl-L-ornithine from L-glutamate relationship: part_of UPa:ULS00043 {cardinality="1", order="4"} ! N(2)-acetyl-L-ornithine from L-glutamate [Term] id: UPa:UER00110 name: L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 N(2)-acetyl-L-ornithine => 1 L-ornithine + 1 acetate." [] xref: EC:3.5.1.16 xref: GO:0008777 "molecular_function:acetylornithine deacetylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00437 ! N(2)-acetyl-L-ornithine relationship: has_input_compound UPa:UPC00437 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_output_compound UPa:UPC00077 ! L-ornithine relationship: part_of UPa:ULS00044 ! L-ornithine from N(2)-acetyl-L-ornithine (linear) relationship: part_of UPa:ULS00044 {cardinality="1", order="1"} ! L-ornithine from N(2)-acetyl-L-ornithine (linear) [Term] id: UPa:UER00111 name: L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1 namespace: enzymatic_reaction def: "1 L-glutamate + 1 N(2)-acetyl-L-ornithine => 1 L-ornithine + 1 N-acetyl-L-glutamate." [] xref: EC:2.3.1.35 xref: GO:0004358 "molecular_function:glutamate N-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00437 ! N(2)-acetyl-L-ornithine relationship: has_input_compound UPa:UPC00437 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_output_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00624 ! N-acetyl-L-glutamate relationship: has_output_compound UPa:UPC00624 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamate relationship: part_of UPa:ULS00045 ! L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic) relationship: part_of UPa:ULS00045 {cardinality="1", order="1"} ! L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic) [Term] id: UPa:UER00112 name: L-arginine from L-ornithine and carbamoyl phosphate: step 1/3 namespace: enzymatic_reaction def: "1 L-ornithine + 1 carbamoyl phosphate => 1 L-citrulline + 1 phosphate." [] xref: EC:2.1.3.3 xref: GO:0004585 "molecular_function:ornithine carbamoyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_input_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="True"} ! carbamoyl phosphate relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00327 {cardinality="1", is_alternate="False", is_primary="True"} ! L-citrulline relationship: has_output_compound UPa:UPC00327 ! L-citrulline relationship: part_of UPa:ULS00046 ! L-arginine from L-ornithine and carbamoyl phosphate relationship: part_of UPa:ULS00046 {cardinality="1", order="1"} ! L-arginine from L-ornithine and carbamoyl phosphate [Term] id: UPa:UER00113 name: L-arginine from L-ornithine and carbamoyl phosphate: step 2/3 namespace: enzymatic_reaction def: "1 ATP + 1 L-aspartate + 1 L-citrulline => 1 (N(omega)-L-arginino)succinate + 1 AMP + 1 diphosphate." [] xref: EC:6.3.4.5 xref: GO:0004055 "molecular_function:argininosuccinate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="False"} ! L-aspartate relationship: has_input_compound UPa:UPC00327 {cardinality="1", is_alternate="False", is_primary="True"} ! L-citrulline relationship: has_input_compound UPa:UPC00327 ! L-citrulline relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC03406 {cardinality="1", is_alternate="False", is_primary="True"} ! (N(omega)-L-arginino)succinate relationship: has_output_compound UPa:UPC03406 ! (N(omega)-L-arginino)succinate relationship: part_of UPa:ULS00046 ! L-arginine from L-ornithine and carbamoyl phosphate relationship: part_of UPa:ULS00046 {cardinality="1", order="2"} ! L-arginine from L-ornithine and carbamoyl phosphate [Term] id: UPa:UER00114 name: L-arginine from L-ornithine and carbamoyl phosphate: step 3/3 namespace: enzymatic_reaction def: "1 (N(omega)-L-arginino)succinate => 1 L-arginine + 1 fumarate." [] xref: EC:4.3.2.1 xref: GO:0004056 "molecular_function:argininosuccinate lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03406 {cardinality="1", is_alternate="False", is_primary="True"} ! (N(omega)-L-arginino)succinate relationship: has_input_compound UPa:UPC03406 ! (N(omega)-L-arginino)succinate relationship: has_output_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_output_compound UPa:UPC00062 ! L-arginine relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="False"} ! fumarate relationship: part_of UPa:ULS00046 ! L-arginine from L-ornithine and carbamoyl phosphate relationship: part_of UPa:ULS00046 {cardinality="1", order="3"} ! L-arginine from L-ornithine and carbamoyl phosphate [Term] id: UPa:UER00115 name: (S)-dihydroorotate from bicarbonate: step 1/3 namespace: enzymatic_reaction def: "2 ATP + 1 H(2)O + 1 L-glutamine + 1 bicarbonate => 2 ADP + 1 L-glutamate + 1 carbamoyl phosphate + 1 phosphate." [] xref: EC:6.3.5.5 xref: GO:0004088 "molecular_function:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00288 {cardinality="1", is_alternate="False", is_primary="True"} ! bicarbonate relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="True"} ! carbamoyl phosphate relationship: part_of UPa:ULS00478 ! (S)-dihydroorotate from bicarbonate relationship: part_of UPa:ULS00478 {cardinality="1", order="1"} ! (S)-dihydroorotate from bicarbonate [Term] id: UPa:UER00116 name: (S)-dihydroorotate from bicarbonate: step 2/3 namespace: enzymatic_reaction def: "1 L-aspartate + 1 carbamoyl phosphate => 1 N-carbamoyl-L-aspartate + 1 phosphate." [] xref: EC:2.1.3.2 xref: GO:0004070 "molecular_function:aspartate carbamoyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="False"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="True"} ! carbamoyl phosphate relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00438 ! N-carbamoyl-L-aspartate relationship: has_output_compound UPa:UPC00438 {cardinality="1", is_alternate="False", is_primary="True"} ! N-carbamoyl-L-aspartate relationship: part_of UPa:ULS00478 ! (S)-dihydroorotate from bicarbonate relationship: part_of UPa:ULS00478 {cardinality="1", order="2"} ! (S)-dihydroorotate from bicarbonate [Term] id: UPa:UER00117 name: (S)-dihydroorotate from bicarbonate: step 3/3 namespace: enzymatic_reaction def: "1 N-carbamoyl-L-aspartate => 1 (S)-dihydroorotate + 1 H(2)O." [] xref: EC:3.5.2.3 xref: GO:0004151 "molecular_function:dihydroorotase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00438 ! N-carbamoyl-L-aspartate relationship: has_input_compound UPa:UPC00438 {cardinality="1", is_alternate="False", is_primary="True"} ! N-carbamoyl-L-aspartate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00337 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00337 ! (S)-dihydroorotate relationship: part_of UPa:ULS00478 ! (S)-dihydroorotate from bicarbonate relationship: part_of UPa:ULS00478 {cardinality="1", order="3"} ! (S)-dihydroorotate from bicarbonate [Term] id: UPa:UER00118 name: orotate from (S)-dihydroorotate (O2 route): step 1/1 namespace: enzymatic_reaction def: "1 (S)-dihydroorotate + 1 fumarate => 1 orotate + 1 succinate." [] xref: EC:1.3.98.1 xref: GO:0004158 "molecular_function:dihydroorotate oxidase activity" xref: GO:1990663 "molecular_function:dihydroorotate dehydrogenase (fumarate) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00122 ! fumarate relationship: has_input_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="False"} ! fumarate relationship: has_input_compound UPa:UPC00337 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00295 {cardinality="1", is_alternate="False", is_primary="True"} ! orotate relationship: has_output_compound UPa:UPC00295 ! orotate relationship: part_of UPa:ULS00479 ! orotate from (S)-dihydroorotate (O2 route) relationship: part_of UPa:ULS00479 {cardinality="1", order="1"} ! orotate from (S)-dihydroorotate (O2 route) [Term] id: UPa:UER00119 name: UMP from orotate: step 1/2 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 orotate => 1 diphosphate + 1 orotidine 5'-phosphate." [] xref: EC:2.4.2.10 xref: GO:0004588 "molecular_function:orotate phosphoribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00295 {cardinality="1", is_alternate="False", is_primary="True"} ! orotate relationship: has_input_compound UPa:UPC00295 ! orotate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC01103 ! orotidine 5'-phosphate relationship: has_output_compound UPa:UPC01103 {cardinality="1", is_alternate="False", is_primary="True"} ! orotidine 5'-phosphate relationship: part_of UPa:ULS00482 ! UMP from orotate relationship: part_of UPa:ULS00482 {cardinality="1", order="1"} ! UMP from orotate [Term] id: UPa:UER00120 name: UMP from orotate: step 2/2 namespace: enzymatic_reaction def: "1 orotidine 5'-phosphate => 1 CO(2) + 1 UMP." [] xref: EC:4.1.1.23 xref: GO:0004590 "molecular_function:orotidine-5'-phosphate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01103 ! orotidine 5'-phosphate relationship: has_input_compound UPa:UPC01103 {cardinality="1", is_alternate="False", is_primary="True"} ! orotidine 5'-phosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00105 ! UMP relationship: has_output_compound UPa:UPC00105 {cardinality="1", is_alternate="False", is_primary="True"} ! UMP relationship: part_of UPa:ULS00482 {cardinality="1", order="2"} ! UMP from orotate relationship: part_of UPa:ULS00482 ! UMP from orotate [Term] id: UPa:UER00121 name: L-ectoine from L-aspartate 4-semialdehyde: step 1/3 namespace: enzymatic_reaction def: "1 L-aspartate 4-semialdehyde + 1 L-glutamate => 1 2-oxoglutarate + 1 L-2,4-diaminobutanoate." [] xref: EC:2.6.1.76 xref: GO:0045303 "molecular_function:diaminobutyrate-2-oxoglutarate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_input_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC03283 ! L-2,4-diaminobutanoate relationship: has_output_compound UPa:UPC03283 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2,4-diaminobutanoate relationship: part_of UPa:ULS00048 {cardinality="1", order="1"} ! L-ectoine from L-aspartate 4-semialdehyde relationship: part_of UPa:ULS00048 ! L-ectoine from L-aspartate 4-semialdehyde [Term] id: UPa:UER00122 name: L-ectoine from L-aspartate 4-semialdehyde: step 2/3 namespace: enzymatic_reaction def: "1 L-2,4-diaminobutanoate + 1 acetyl-CoA => 1 CoA + 1 N(4)-acetyl-L-2,4-diaminobutyric acid." [] xref: EC:2.3.1.178 xref: GO:0033816 "molecular_function:diaminobutyrate acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC03283 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2,4-diaminobutanoate relationship: has_input_compound UPa:UPC03283 ! L-2,4-diaminobutanoate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC06442 ! N(4)-acetyl-L-2,4-diaminobutyric acid relationship: has_output_compound UPa:UPC06442 {cardinality="1", is_alternate="False", is_primary="True"} ! N(4)-acetyl-L-2,4-diaminobutyric acid relationship: part_of UPa:ULS00048 {cardinality="1", order="2"} ! L-ectoine from L-aspartate 4-semialdehyde relationship: part_of UPa:ULS00048 ! L-ectoine from L-aspartate 4-semialdehyde [Term] id: UPa:UER00123 name: L-ectoine from L-aspartate 4-semialdehyde: step 3/3 namespace: enzymatic_reaction def: "1 N(4)-acetyl-L-2,4-diaminobutyric acid => 1 H(2)O + 1 L-ectoine." [] xref: EC:4.2.1.108 xref: GO:0033990 "molecular_function:ectoine synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC06442 ! N(4)-acetyl-L-2,4-diaminobutyric acid relationship: has_input_compound UPa:UPC06442 {cardinality="1", is_alternate="False", is_primary="True"} ! N(4)-acetyl-L-2,4-diaminobutyric acid relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC06231 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ectoine relationship: has_output_compound UPa:UPC06231 ! L-ectoine relationship: part_of UPa:ULS00048 {cardinality="1", order="3"} ! L-ectoine from L-aspartate 4-semialdehyde relationship: part_of UPa:ULS00048 ! L-ectoine from L-aspartate 4-semialdehyde [Term] id: UPa:UER00124 name: N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 H(2)O + 1 L-glutamine => 1 5-phospho-beta-D-ribosylamine + 1 L-glutamate + 1 diphosphate." [] xref: EC:2.4.2.14 xref: GO:0004044 "molecular_function:amidophosphoribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC03090 ! 5-phospho-beta-D-ribosylamine relationship: has_output_compound UPa:UPC03090 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-beta-D-ribosylamine relationship: part_of UPa:ULS00050 {cardinality="1", order="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00050 ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00125 name: N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2 namespace: enzymatic_reaction def: "1 5-phospho-beta-D-ribosylamine + 1 ATP + 1 glycine => 1 ADP + 1 N(1)-(5-phospho-D-ribosyl)glycinamide + 1 phosphate." [] xref: EC:6.3.4.13 xref: GO:0004637 "molecular_function:phosphoribosylamine-glycine ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="False"} ! glycine relationship: has_input_compound UPa:UPC03090 ! 5-phospho-beta-D-ribosylamine relationship: has_input_compound UPa:UPC03090 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-beta-D-ribosylamine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC03838 {cardinality="1", is_alternate="False", is_primary="True"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC03838 ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:ULS00050 {cardinality="1", order="2"} ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00050 ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00126 name: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1 namespace: enzymatic_reaction def: "1 10-formyl-5,6,7,8-tetrahydrofolate + 1 N(1)-(5-phospho-D-ribosyl)glycinamide => 1 5,6,7,8-tetrahydrofolate + 1 N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide." [] xref: EC:2.1.2.2 xref: GO:0004644 "molecular_function:phosphoribosylglycinamide formyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00234 {cardinality="1", is_alternate="False", is_primary="False"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00234 ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC03838 {cardinality="1", is_alternate="False", is_primary="True"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_input_compound UPa:UPC03838 ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC04376 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC04376 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:ULS00051 {cardinality="1", order="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route) relationship: part_of UPa:ULS00051 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route) [Term] id: UPa:UER00127 name: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 N(1)-(5-phospho-D-ribosyl)glycinamide + 1 formate => 1 ADP + 1 N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + 1 phosphate." [] xref: EC:2.1.2 xref: GO:0016742 "molecular_function:hydroxymethyl-, formyl- and related transferase activity" xref: GO:0030407 "molecular_function:formimidoyltransferase activity" xref: GO:0043815 "molecular_function:phosphoribosylglycinamide formyltransferase 2 activity" xref: GO:0044685 "molecular_function:tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_input_compound UPa:UPC00058 ! formate relationship: has_input_compound UPa:UPC03838 {cardinality="1", is_alternate="False", is_primary="True"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_input_compound UPa:UPC03838 ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC04376 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC04376 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:ULS00052 {cardinality="1", order="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route) relationship: part_of UPa:ULS00052 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route) [Term] id: UPa:UER00128 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 H(2)O + 1 L-glutamine + 1 N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide => 1 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine + 1 ADP + 1 L-glutamate + 1 phosphate." [] xref: EC:6.3.5.3 xref: GO:0004642 "molecular_function:phosphoribosylformylglycinamidine synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC04376 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_input_compound UPa:UPC04376 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC04640 ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine relationship: has_output_compound UPa:UPC04640 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine relationship: part_of UPa:ULS00470 {cardinality="1", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:ULS00470 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide [Term] id: UPa:UER00129 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2 namespace: enzymatic_reaction def: "1 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine + 1 ATP => 1 5-amino-1-(5-phospho-D-ribosyl)imidazole + 1 ADP + 1 phosphate." [] xref: EC:6.3.3.1 xref: GO:0004641 "molecular_function:phosphoribosylformylglycinamidine cyclo-ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC04640 ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine relationship: has_input_compound UPa:UPC04640 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC03373 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:ULS00470 {cardinality="1", order="2"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:ULS00470 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide [Term] id: UPa:UER00130 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1 namespace: enzymatic_reaction def: "1 5-amino-1-(5-phospho-D-ribosyl)imidazole + 1 CO(2) => 1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate." [] xref: EC:4.1.1.21 xref: GO:0004638 "molecular_function:phosphoribosylaminoimidazole carboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC03373 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_input_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC04751 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_output_compound UPa:UPC04751 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: part_of UPa:ULS00471 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route) relationship: part_of UPa:ULS00471 {cardinality="1", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route) [Term] id: UPa:UER00131 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2 namespace: enzymatic_reaction def: "1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 1 ATP + 1 L-aspartate => 1 (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid + 1 ADP + 1 phosphate." [] xref: EC:6.3.2.6 xref: GO:0004639 "molecular_function:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="False"} ! L-aspartate relationship: has_input_compound UPa:UPC04751 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_input_compound UPa:UPC04751 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC04823 ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid relationship: has_output_compound UPa:UPC04823 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid relationship: part_of UPa:ULS00473 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: part_of UPa:ULS00473 {cardinality="1", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [Term] id: UPa:UER00132 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2 namespace: enzymatic_reaction def: "1 (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid => 1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 1 fumarate." [] xref: EC:4.3.2.2 xref: GO:0004018 "molecular_function:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity" xref: GO:0070626 "molecular_function:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04823 ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid relationship: has_input_compound UPa:UPC04823 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid relationship: has_output_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="False"} ! fumarate relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC04677 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00473 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: part_of UPa:ULS00473 {cardinality="1", order="2"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [Term] id: UPa:UER00133 name: 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1 namespace: enzymatic_reaction def: "1 10-formyl-5,6,7,8-tetrahydrofolate + 1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => 1 5,6,7,8-tetrahydrofolate + 1 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [] xref: EC:2.1.2.3 xref: GO:0004643 "molecular_function:phosphoribosylaminoimidazolecarboxamide formyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00234 {cardinality="1", is_alternate="False", is_primary="False"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00234 ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC04677 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC04734 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04734 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00054 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route) relationship: part_of UPa:ULS00054 {cardinality="1", order="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route) [Term] id: UPa:UER00134 name: 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1 namespace: enzymatic_reaction def: "1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 1 ATP + 1 formate => 1 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 1 ADP + 1 phosphate." [] xref: EC:6.3.4 xref: GO:0016979 "molecular_function:lipoate-protein ligase activity" xref: GO:0018271 "molecular_function:biotin-protein ligase activity" xref: GO:0032267 "molecular_function:tRNA(Ile)-lysidine synthase activity" xref: GO:0071734 "molecular_function:biotin-[pyruvate-carboxylase] ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00058 ! formate relationship: has_input_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_input_compound UPa:UPC04677 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC04734 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04734 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00055 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route) relationship: part_of UPa:ULS00055 {cardinality="1", order="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route) [Term] id: UPa:UER00135 name: IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1 namespace: enzymatic_reaction def: "1 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => 1 H(2)O + 1 IMP." [] xref: EC:3.5.4.10 xref: GO:0003937 "molecular_function:IMP cyclohydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04734 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04734 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00130 {cardinality="1", is_alternate="False", is_primary="True"} ! IMP relationship: has_output_compound UPa:UPC00130 ! IMP relationship: part_of UPa:ULS00056 ! IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00056 {cardinality="1", order="1"} ! IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [Term] id: UPa:UER00136 name: 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 1/3 namespace: enzymatic_reaction def: "1 5-amino-1-(5-phospho-D-ribosyl)imidazole => 1 4-amino-5-hydroxymethyl-2-methylpyrimidine." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_input_compound UPa:UPC03373 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC01279 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC01279 ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: part_of UPa:ULS00057 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:ULS00057 {cardinality="1", order="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole [Term] id: UPa:UER00137 name: 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3 namespace: enzymatic_reaction def: "1 4-amino-5-hydroxymethyl-2-methylpyrimidine + 1 ATP => 1 4-amino-2-methyl-5-phosphomethylpyrimidine + 1 ADP." [] xref: EC:2.7.1.49 xref: GO:0008902 "molecular_function:hydroxymethylpyrimidine kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC01279 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_input_compound UPa:UPC01279 ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC04556 ! 4-amino-2-methyl-5-phosphomethylpyrimidine relationship: has_output_compound UPa:UPC04556 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-2-methyl-5-phosphomethylpyrimidine relationship: part_of UPa:ULS00057 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:ULS00057 {cardinality="1", order="2"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole [Term] id: UPa:UER00138 name: 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3 namespace: enzymatic_reaction def: "1 4-amino-2-methyl-5-phosphomethylpyrimidine + 1 ATP => 1 4-amino-2-methyl-5-diphosphomethylpyrimidine + 1 ADP." [] xref: EC:2.7.4.7 xref: GO:0008972 "molecular_function:phosphomethylpyrimidine kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC04556 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-2-methyl-5-phosphomethylpyrimidine relationship: has_input_compound UPa:UPC04556 ! 4-amino-2-methyl-5-phosphomethylpyrimidine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC04752 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: has_output_compound UPa:UPC04752 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: part_of UPa:ULS00057 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:ULS00057 {cardinality="1", order="3"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole [Term] id: UPa:UER00139 name: 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1 namespace: enzymatic_reaction def: "1 5-(2-hydroxyethyl)-4-methylthiazole + 1 ATP => 1 4-methyl-5-(2-phosphoethyl)-thiazole + 1 ADP." [] xref: EC:2.7.1.50 xref: GO:0004417 "molecular_function:hydroxyethylthiazole kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC04294 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: has_input_compound UPa:UPC04294 ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC04327 ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_output_compound UPa:UPC04327 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: part_of UPa:ULS00058 ! 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole relationship: part_of UPa:ULS00058 {cardinality="1", order="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole [Term] id: UPa:UER00140 name: 4-methyl-5-(2-phosphoethyl)-thiazole from 1-deoxy-D-xylulose 5-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 1-deoxy-D-xylulose 5-phosphate => 1 4-methyl-5-(2-phosphoethyl)-thiazole." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC11437 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC04327 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_output_compound UPa:UPC04327 ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: part_of UPa:ULS00059 {cardinality="1", order="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole from 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:ULS00059 ! 4-methyl-5-(2-phosphoethyl)-thiazole from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00141 name: thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1 namespace: enzymatic_reaction def: "1 4-amino-2-methyl-5-diphosphomethylpyrimidine + 1 4-methyl-5-(2-phosphoethyl)-thiazole => 1 diphosphate + 1 thiamine phosphate." [] xref: EC:2.5.1.3 xref: GO:0004789 "molecular_function:thiamine-phosphate diphosphorylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04327 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_input_compound UPa:UPC04327 ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_input_compound UPa:UPC04752 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: has_input_compound UPa:UPC04752 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC01081 ! thiamine phosphate relationship: has_output_compound UPa:UPC01081 {cardinality="1", is_alternate="False", is_primary="True"} ! thiamine phosphate relationship: part_of UPa:ULS00060 {cardinality="1", order="1"} ! thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole relationship: part_of UPa:ULS00060 ! thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole [Term] id: UPa:UER00142 name: thiamine diphosphate from thiamine phosphate: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 thiamine phosphate => 1 ADP + 1 thiamine diphosphate." [] xref: EC:2.7.4.16 xref: GO:0009030 "molecular_function:thiamine-phosphate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01081 {cardinality="1", is_alternate="False", is_primary="True"} ! thiamine phosphate relationship: has_input_compound UPa:UPC01081 ! thiamine phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00068 {cardinality="1", is_alternate="False", is_primary="True"} ! thiamine diphosphate relationship: has_output_compound UPa:UPC00068 ! thiamine diphosphate relationship: part_of UPa:ULS00283 {cardinality="1", order="1"} ! thiamine diphosphate from thiamine phosphate relationship: part_of UPa:ULS00283 ! thiamine diphosphate from thiamine phosphate [Term] id: UPa:UER00143 name: acetyl-CoA from myo-inositol: step 1/7 namespace: enzymatic_reaction def: "1 NAD(+) + 1 myo-inositol => 1 H(+) + 1 NADH + 1 scyllo-inosose." [] xref: EC:1.1.1.18 xref: GO:0050112 "molecular_function:inositol 2-dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00137 ! myo-inositol relationship: has_input_compound UPa:UPC00137 {cardinality="1", is_alternate="False", is_primary="True"} ! myo-inositol relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00691 {cardinality="1", is_alternate="False", is_primary="True"} ! scyllo-inosose relationship: has_output_compound UPa:UPC00691 ! scyllo-inosose relationship: part_of UPa:ULS00061 {cardinality="1", order="1"} ! acetyl-CoA from myo-inositol relationship: part_of UPa:ULS00061 ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00144 name: acetyl-CoA from myo-inositol: step 2/7 namespace: enzymatic_reaction def: "1 scyllo-inosose => 1 3D-3,5/4-trihydroxycyclohexane-1,2-dione + 1 H(2)O." [] xref: EC:4.2.1.44 xref: GO:0050114 "molecular_function:myo-inosose-2 dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00691 {cardinality="1", is_alternate="False", is_primary="True"} ! scyllo-inosose relationship: has_input_compound UPa:UPC00691 ! scyllo-inosose relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC04287 ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione relationship: has_output_compound UPa:UPC04287 {cardinality="1", is_alternate="False", is_primary="True"} ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione relationship: part_of UPa:ULS00061 {cardinality="1", order="2"} ! acetyl-CoA from myo-inositol relationship: part_of UPa:ULS00061 ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00145 name: acetyl-CoA from myo-inositol: step 3/7 namespace: enzymatic_reaction def: "1 3D-3,5/4-trihydroxycyclohexane-1,2-dione + 1 H(2)O => 1 5-deoxy-D-glucuronic acid." [] xref: EC:3.7.1.22 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04287 ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione relationship: has_input_compound UPa:UPC04287 {cardinality="1", is_alternate="False", is_primary="True"} ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione relationship: has_output_compound UPa:UPC16737 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-deoxy-D-glucuronic acid relationship: has_output_compound UPa:UPC16737 ! 5-deoxy-D-glucuronic acid relationship: part_of UPa:ULS00061 {cardinality="1", order="3"} ! acetyl-CoA from myo-inositol relationship: part_of UPa:ULS00061 ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00146 name: acetyl-CoA from myo-inositol: step 5/7 namespace: enzymatic_reaction def: "1 2-deoxy-5-keto-D-gluconic acid + 1 ATP => 1 6-phospho-5-dehydro-2-deoxy-D-gluconic acid + 1 ADP." [] xref: EC:2.7.1.92 xref: GO:0047590 "molecular_function:5-dehydro-2-deoxygluconokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC06892 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxy-5-keto-D-gluconic acid relationship: has_input_compound UPa:UPC06892 ! 2-deoxy-5-keto-D-gluconic acid relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC06893 ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid relationship: has_output_compound UPa:UPC06893 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid relationship: part_of UPa:ULS00061 {cardinality="1", order="5"} ! acetyl-CoA from myo-inositol relationship: part_of UPa:ULS00061 ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00147 name: acetyl-CoA from myo-inositol: step 6/7 namespace: enzymatic_reaction def: "1 6-phospho-5-dehydro-2-deoxy-D-gluconic acid => 1 3-oxopropanoate + 1 glycerone phosphate." [] xref: EC:4.1.2.29 xref: GO:0047441 "molecular_function:5-dehydro-2-deoxyphosphogluconate aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC06893 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid relationship: has_input_compound UPa:UPC06893 ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="False"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00222 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxopropanoate relationship: has_output_compound UPa:UPC00222 ! 3-oxopropanoate relationship: part_of UPa:ULS00061 {cardinality="1", order="6"} ! acetyl-CoA from myo-inositol relationship: part_of UPa:ULS00061 ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00148 name: acetyl-CoA from myo-inositol: step 7/7 namespace: enzymatic_reaction def: "3-oxopropanoate + CoA + [NAD(+) or NADP(+)] => CO(2) + H(+) + acetyl-CoA + [NADH or NADPH]." [] xref: EC:1.2.1.18 xref: EC:1.2.1.27 xref: GO:0004491 "molecular_function:methylmalonate-semialdehyde dehydrogenase (acylating) activity" xref: GO:0018478 "molecular_function:malonate-semialdehyde dehydrogenase (acetylating) activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00951 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00952 ! None relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00222 ! 3-oxopropanoate relationship: has_input_compound UPa:UPC00222 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxopropanoate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: part_of UPa:ULS00061 {cardinality="1", order="7"} ! acetyl-CoA from myo-inositol relationship: part_of UPa:ULS00061 ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00149 name: 4-aminobenzoate from chorismate: step 1/2 namespace: enzymatic_reaction def: "1 L-glutamine + 1 NH(3) + 1 chorismate => 1 4-amino-4-deoxychorismate + 1 L-glutamate." [] xref: EC:2.6.1.85 xref: GO:0046820 "molecular_function:4-amino-4-deoxychorismate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00251 {cardinality="1", is_alternate="False", is_primary="True"} ! chorismate relationship: has_input_compound UPa:UPC00251 ! chorismate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC11355 ! 4-amino-4-deoxychorismate relationship: has_output_compound UPa:UPC11355 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-4-deoxychorismate relationship: part_of UPa:ULS00062 {cardinality="1", order="1"} ! 4-aminobenzoate from chorismate relationship: part_of UPa:ULS00062 ! 4-aminobenzoate from chorismate [Term] id: UPa:UER00150 name: 4-aminobenzoate from chorismate: step 2/2 namespace: enzymatic_reaction def: "1 4-amino-4-deoxychorismate => 1 4-aminobenzoate + 1 pyruvate." [] xref: EC:4.1.3.38 xref: GO:0008696 "molecular_function:4-amino-4-deoxychorismate lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC11355 ! 4-amino-4-deoxychorismate relationship: has_input_compound UPa:UPC11355 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-4-deoxychorismate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_output_compound UPa:UPC00568 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobenzoate relationship: has_output_compound UPa:UPC00568 ! 4-aminobenzoate relationship: part_of UPa:ULS00062 ! 4-aminobenzoate from chorismate relationship: part_of UPa:ULS00062 {cardinality="1", order="2"} ! 4-aminobenzoate from chorismate [Term] id: UPa:UER00151 name: 7,8-dihydroneopterin triphosphate from GTP: step 1/1 namespace: enzymatic_reaction def: "1 GTP + 1 H(2)O => 1 7,8-dihydroneopterin triphosphate + 1 formate." [] xref: EC:3.5.4.16 xref: GO:0003934 "molecular_function:GTP cyclohydrolase I activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00044 {cardinality="1", is_alternate="False", is_primary="True"} ! GTP relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_output_compound UPa:UPC04895 ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC04895 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin triphosphate relationship: part_of UPa:ULS00410 ! 7,8-dihydroneopterin triphosphate from GTP relationship: part_of UPa:ULS00410 {cardinality="1", order="1"} ! 7,8-dihydroneopterin triphosphate from GTP [Term] id: UPa:UER00152 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 1/4 namespace: enzymatic_reaction def: "1 7,8-dihydroneopterin triphosphate + 1 H(2)O => 1 7,8-dihydroneopterin 3'-phosphate + 1 diphosphate." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC04895 ! 7,8-dihydroneopterin triphosphate relationship: has_input_compound UPa:UPC04895 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC05925 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin 3'-phosphate relationship: has_output_compound UPa:UPC05925 ! 7,8-dihydroneopterin 3'-phosphate relationship: part_of UPa:ULS00063 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate relationship: part_of UPa:ULS00063 {cardinality="1", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate [Term] id: UPa:UER00153 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 2/4 namespace: enzymatic_reaction def: "1 7,8-dihydroneopterin 3'-phosphate + 1 H(2)O => 1 7,8-dihydroneopterin + 1 phosphate." [] xref: EC:3.6.1 xref: GO:0004787 "molecular_function:thiamine-pyrophosphatase activity" xref: GO:0008413 "molecular_function:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity" xref: GO:0008758 "molecular_function:UDP-2,3-diacylglucosamine hydrolase activity" xref: GO:0008796 "molecular_function:bis(5'-nucleosyl)-tetraphosphatase activity" xref: GO:0008828 "molecular_function:dATP pyrophosphohydrolase activity" xref: GO:0016462 "molecular_function:pyrophosphatase activity" xref: GO:0016818 "molecular_function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" xref: GO:0019176 "molecular_function:dihydroneopterin monophosphate phosphatase activity" xref: GO:0019177 "molecular_function:dihydroneopterin triphosphate pyrophosphohydrolase activity" xref: GO:0035870 "molecular_function:dITP diphosphatase activity" xref: GO:0036218 "molecular_function:dTTP diphosphatase activity" xref: GO:0036222 "molecular_function:XTP diphosphatase activity" xref: GO:0043141 "molecular_function:ATP-dependent 5'-3' DNA helicase activity" xref: GO:0044606 "molecular_function:phosphocholine hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC05925 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin 3'-phosphate relationship: has_input_compound UPa:UPC05925 ! 7,8-dihydroneopterin 3'-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC04874 ! 7,8-dihydroneopterin relationship: has_output_compound UPa:UPC04874 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin relationship: part_of UPa:ULS00063 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate relationship: part_of UPa:ULS00063 {cardinality="1", order="2"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate [Term] id: UPa:UER00154 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4 namespace: enzymatic_reaction def: "1 7,8-dihydroneopterin => 1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 1 glycolaldehyde." [] xref: EC:4.1.2.25 xref: GO:0004150 "molecular_function:dihydroneopterin aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04874 ! 7,8-dihydroneopterin relationship: has_input_compound UPa:UPC04874 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin relationship: has_output_compound UPa:UPC00266 ! glycolaldehyde relationship: has_output_compound UPa:UPC00266 {cardinality="1", is_alternate="False", is_primary="False"} ! glycolaldehyde relationship: has_output_compound UPa:UPC01300 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine relationship: has_output_compound UPa:UPC01300 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine relationship: part_of UPa:ULS00063 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate relationship: part_of UPa:ULS00063 {cardinality="1", order="3"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate [Term] id: UPa:UER00155 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4 namespace: enzymatic_reaction def: "1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 1 ATP => 1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 1 AMP." [] xref: EC:2.7.6.3 xref: GO:0003848 "molecular_function:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01300 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine relationship: has_input_compound UPa:UPC01300 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC04807 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: has_output_compound UPa:UPC04807 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: part_of UPa:ULS00063 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate relationship: part_of UPa:ULS00063 {cardinality="1", order="4"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate [Term] id: UPa:UER00156 name: 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2 namespace: enzymatic_reaction def: "1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 1 4-aminobenzoate => 1 7,8-dihydropteroate + 1 diphosphate." [] xref: EC:2.5.1.15 xref: GO:0004156 "molecular_function:dihydropteroate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00568 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobenzoate relationship: has_input_compound UPa:UPC00568 ! 4-aminobenzoate relationship: has_input_compound UPa:UPC04807 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: has_input_compound UPa:UPC04807 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00921 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydropteroate relationship: has_output_compound UPa:UPC00921 ! 7,8-dihydropteroate relationship: part_of UPa:ULS00064 ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate relationship: part_of UPa:ULS00064 {cardinality="1", order="1"} ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate [Term] id: UPa:UER00157 name: 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2 namespace: enzymatic_reaction def: "1 7,8-dihydropteroate + 1 ATP + 1 L-glutamate => 1 7,8-dihydrofolate + 1 ADP + 1 phosphate." [] xref: EC:6.3.2.12 xref: GO:0008841 "molecular_function:dihydrofolate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00921 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydropteroate relationship: has_input_compound UPa:UPC00921 ! 7,8-dihydropteroate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00415 ! 7,8-dihydrofolate relationship: has_output_compound UPa:UPC00415 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydrofolate relationship: part_of UPa:ULS00064 ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate relationship: part_of UPa:ULS00064 {cardinality="1", order="2"} ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate [Term] id: UPa:UER00158 name: 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1 namespace: enzymatic_reaction def: "1 7,8-dihydrofolate + 1 H(+) + 1 NADPH => 1 5,6,7,8-tetrahydrofolate + 1 NADP(+)." [] xref: EC:1.5.1.3 xref: GO:0004146 "molecular_function:dihydrofolate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00415 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydrofolate relationship: has_input_compound UPa:UPC00415 ! 7,8-dihydrofolate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:ULS00411 ! 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate relationship: part_of UPa:ULS00411 {cardinality="1", order="1"} ! 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate [Term] id: UPa:UER00159 name: 8-amino-7-oxononanoate from pimeloyl-CoA: step 1/1 namespace: enzymatic_reaction def: "1 L-alanine + 1 pimeloyl-CoA => 1 8-amino-7-oxononanoate + 1 CO(2) + 1 CoA." [] xref: EC:2.3.1.47 xref: GO:0008710 "molecular_function:8-amino-7-oxononanoate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_input_compound UPa:UPC00041 {cardinality="1", is_alternate="False", is_primary="False"} ! L-alanine relationship: has_input_compound UPa:UPC01063 {cardinality="1", is_alternate="False", is_primary="True"} ! pimeloyl-CoA relationship: has_input_compound UPa:UPC01063 ! pimeloyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC01092 {cardinality="1", is_alternate="False", is_primary="True"} ! 8-amino-7-oxononanoate relationship: has_output_compound UPa:UPC01092 ! 8-amino-7-oxononanoate relationship: part_of UPa:ULS00474 ! 8-amino-7-oxononanoate from pimeloyl-CoA relationship: part_of UPa:ULS00474 {cardinality="1", order="1"} ! 8-amino-7-oxononanoate from pimeloyl-CoA [Term] id: UPa:UER00160 name: 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1 namespace: enzymatic_reaction def: "1 8-amino-7-oxononanoate + 1 S-adenosyl-L-methionine => 1 7,8-diaminononanoate + 1 S-adenosyl-4-methylthio-2-oxobutanoic acid." [] xref: EC:2.6.1.62 xref: GO:0004015 "molecular_function:adenosylmethionine-8-amino-7-oxononanoate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01092 {cardinality="1", is_alternate="False", is_primary="True"} ! 8-amino-7-oxononanoate relationship: has_input_compound UPa:UPC01092 ! 8-amino-7-oxononanoate relationship: has_output_compound UPa:UPC01037 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC01037 ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC04425 ! S-adenosyl-4-methylthio-2-oxobutanoic acid relationship: has_output_compound UPa:UPC04425 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-4-methylthio-2-oxobutanoic acid relationship: part_of UPa:ULS00475 {cardinality="1", order="1"} ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route) relationship: part_of UPa:ULS00475 ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route) [Term] id: UPa:UER00161 name: biotin from 7,8-diaminononanoate: step 1/2 namespace: enzymatic_reaction def: "1 7,8-diaminononanoate + 1 ATP + 1 CO(2) => 1 ADP + 1 dethiobiotin + 1 phosphate." [] xref: EC:6.3.3.3 xref: GO:0004141 "molecular_function:dethiobiotin synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_input_compound UPa:UPC01037 ! 7,8-diaminononanoate relationship: has_input_compound UPa:UPC01037 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC01909 {cardinality="1", is_alternate="False", is_primary="True"} ! dethiobiotin relationship: has_output_compound UPa:UPC01909 ! dethiobiotin relationship: part_of UPa:ULS00477 {cardinality="1", order="1"} ! biotin from 7,8-diaminononanoate relationship: part_of UPa:ULS00477 ! biotin from 7,8-diaminononanoate [Term] id: UPa:UER00162 name: biotin from 7,8-diaminononanoate: step 2/2 namespace: enzymatic_reaction def: "2 H(+) + 2 S-adenosyl-L-methionine + 1 dethiobiotin + 2 e- + 1 sulfur donor => 2 5'-deoxyadenosine + 2 L-methionine + 1 biotin." [] xref: EC:2.8.1.6 xref: GO:0004076 "molecular_function:biotin synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01909 {cardinality="1", is_alternate="False", is_primary="True"} ! dethiobiotin relationship: has_input_compound UPa:UPC01909 ! dethiobiotin relationship: has_input_compound UPa:UPC05359 {cardinality="1", is_alternate="False", is_primary="False"} ! e- relationship: has_input_compound UPa:UPC05359 ! e- relationship: has_input_compound UPa:UPC17023 ! sulfur donor relationship: has_input_compound UPa:UPC17023 {cardinality="1", is_alternate="False", is_primary="False"} ! sulfur donor relationship: has_output_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="False"} ! L-methionine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC00120 ! biotin relationship: has_output_compound UPa:UPC00120 {cardinality="1", is_alternate="False", is_primary="True"} ! biotin relationship: has_output_compound UPa:UPC05198 {cardinality="1", is_alternate="False", is_primary="False"} ! 5'-deoxyadenosine relationship: has_output_compound UPa:UPC05198 ! 5'-deoxyadenosine relationship: part_of UPa:ULS00477 ! biotin from 7,8-diaminononanoate relationship: part_of UPa:ULS00477 {cardinality="1", order="2"} ! biotin from 7,8-diaminononanoate [Term] id: UPa:UER00163 name: 1,4-dihydroxy-2-naphthoate from chorismate: step 1/7 namespace: enzymatic_reaction def: "1 chorismate => 1 isochorismate." [] xref: EC:5.4.4.2 xref: GO:0008909 "molecular_function:isochorismate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00251 ! chorismate relationship: has_input_compound UPa:UPC00251 {cardinality="1", is_alternate="False", is_primary="True"} ! chorismate relationship: has_output_compound UPa:UPC00885 {cardinality="1", is_alternate="False", is_primary="True"} ! isochorismate relationship: has_output_compound UPa:UPC00885 ! isochorismate relationship: part_of UPa:ULS00509 {cardinality="1", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate relationship: part_of UPa:ULS00509 ! 1,4-dihydroxy-2-naphthoate from chorismate [Term] id: UPa:UER00164 name: 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 isochorismate => 1 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid + 1 CO(2)." [] xref: EC:2.2.1.9 xref: GO:0070204 "molecular_function:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00885 {cardinality="1", is_alternate="False", is_primary="True"} ! isochorismate relationship: has_input_compound UPa:UPC00885 ! isochorismate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC16519 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid relationship: has_output_compound UPa:UPC16519 ! 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid relationship: part_of UPa:ULS00509 {cardinality="1", order="2"} ! 1,4-dihydroxy-2-naphthoate from chorismate relationship: part_of UPa:ULS00509 ! 1,4-dihydroxy-2-naphthoate from chorismate [Term] id: UPa:UER00165 name: 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7 namespace: enzymatic_reaction def: "1 (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid => 1 2-succinylbenzoate + 1 H(2)O." [] xref: EC:4.2.1.113 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC05817 {cardinality="1", is_alternate="False", is_primary="True"} ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid relationship: has_input_compound UPa:UPC05817 ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC02730 ! 2-succinylbenzoate relationship: has_output_compound UPa:UPC02730 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-succinylbenzoate relationship: part_of UPa:ULS00509 ! 1,4-dihydroxy-2-naphthoate from chorismate relationship: part_of UPa:ULS00509 {cardinality="1", order="4"} ! 1,4-dihydroxy-2-naphthoate from chorismate [Term] id: UPa:UER00166 name: 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7 namespace: enzymatic_reaction def: "1 2-succinylbenzoate + 1 ATP + 1 CoA => 1 2-succinylbenzoyl-CoA + 1 AMP + 1 diphosphate." [] xref: EC:6.2.1.26 xref: GO:0008756 "molecular_function:o-succinylbenzoate-CoA ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC02730 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-succinylbenzoate relationship: has_input_compound UPa:UPC02730 ! 2-succinylbenzoate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC03160 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-succinylbenzoyl-CoA relationship: has_output_compound UPa:UPC03160 ! 2-succinylbenzoyl-CoA relationship: part_of UPa:ULS00509 {cardinality="1", order="5"} ! 1,4-dihydroxy-2-naphthoate from chorismate relationship: part_of UPa:ULS00509 ! 1,4-dihydroxy-2-naphthoate from chorismate [Term] id: UPa:UER00167 name: 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7 namespace: enzymatic_reaction def: "1 2-succinylbenzoyl-CoA => 1 1,4-dihydroxy-2-naphthoyl-CoA + 1 H(2)O." [] xref: EC:4.1.3.36 xref: GO:0008935 "molecular_function:1,4-dihydroxy-2-naphthoyl-CoA synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03160 ! 2-succinylbenzoyl-CoA relationship: has_input_compound UPa:UPC03160 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-succinylbenzoyl-CoA relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC15547 {cardinality="1", is_alternate="False", is_primary="True"} ! 1,4-dihydroxy-2-naphthoyl-CoA relationship: has_output_compound UPa:UPC15547 ! 1,4-dihydroxy-2-naphthoyl-CoA relationship: part_of UPa:ULS00509 {cardinality="1", order="6"} ! 1,4-dihydroxy-2-naphthoate from chorismate relationship: part_of UPa:ULS00509 ! 1,4-dihydroxy-2-naphthoate from chorismate [Term] id: UPa:UER00168 name: menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2 namespace: enzymatic_reaction def: "1 1,4-dihydroxy-2-naphthoate + 1 all-trans-polyprenyl diphosphate => 1 CO(2) + 1 demethylmenaquinol + 1 diphosphate." [] xref: EC:2.5.1.74 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03657 {cardinality="1", is_alternate="False", is_primary="True"} ! 1,4-dihydroxy-2-naphthoate relationship: has_input_compound UPa:UPC03657 ! 1,4-dihydroxy-2-naphthoate relationship: has_input_compound UPa:UPC05847 ! all-trans-polyprenyl diphosphate relationship: has_input_compound UPa:UPC05847 {cardinality="1", is_alternate="False", is_primary="False"} ! all-trans-polyprenyl diphosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC19847 ! demethylmenaquinol relationship: has_output_compound UPa:UPC19847 {cardinality="1", is_alternate="False", is_primary="True"} ! demethylmenaquinol relationship: part_of UPa:ULS00510 ! menaquinol from 1,4-dihydroxy-2-naphthoate relationship: part_of UPa:ULS00510 {cardinality="1", order="1"} ! menaquinol from 1,4-dihydroxy-2-naphthoate [Term] id: UPa:UER00169 name: menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 demethylmenaquinol => 1 S-adenosyl-L-homocysteine + 1 menaquinol." [] xref: EC:2.1.1.163 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC19847 {cardinality="1", is_alternate="False", is_primary="True"} ! demethylmenaquinol relationship: has_input_compound UPa:UPC19847 ! demethylmenaquinol relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC05819 {cardinality="1", is_alternate="False", is_primary="True"} ! menaquinol relationship: has_output_compound UPa:UPC05819 ! menaquinol relationship: part_of UPa:ULS00510 {cardinality="1", order="2"} ! menaquinol from 1,4-dihydroxy-2-naphthoate relationship: part_of UPa:ULS00510 ! menaquinol from 1,4-dihydroxy-2-naphthoate [Term] id: UPa:UER00170 name: formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1 namespace: enzymatic_reaction def: "1 10-formyl-5,6,7,8-tetrahydrofolate + 1 H(2)O => 1 5,6,7,8-tetrahydrofolate + 1 formate." [] xref: EC:3.5.1.10 xref: GO:0008864 "molecular_function:formyltetrahydrofolate deformylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00234 ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00234 {cardinality="1", is_alternate="False", is_primary="True"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="True"} ! formate relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:ULS00067 ! formate from 10-formyl-5,6,7,8-tetrahydrofolate relationship: part_of UPa:ULS00067 {cardinality="1", order="1"} ! formate from 10-formyl-5,6,7,8-tetrahydrofolate [Term] id: UPa:UER00171 name: carbamoyl phosphate from bicarbonate: step 1/1 namespace: enzymatic_reaction def: "2 ATP + 1 H(2)O + 1 L-glutamine + 1 bicarbonate => 2 ADP + 1 L-glutamate + 1 carbamoyl phosphate + 1 phosphate." [] xref: EC:6.3.5.5 xref: GO:0004088 "molecular_function:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00288 {cardinality="1", is_alternate="False", is_primary="True"} ! bicarbonate relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="True"} ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00169 ! carbamoyl phosphate relationship: part_of UPa:ULS00068 ! carbamoyl phosphate from bicarbonate relationship: part_of UPa:ULS00068 {cardinality="1", order="1"} ! carbamoyl phosphate from bicarbonate [Term] id: UPa:UER00172 name: 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 D-ribose 5-phosphate => 1 5-phospho-alpha-D-ribose 1-diphosphate + 1 AMP." [] xref: EC:2.7.6.1 xref: GO:0004749 "molecular_function:ribose phosphate diphosphokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: has_input_compound UPa:UPC00117 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00070 ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I) relationship: part_of UPa:ULS00070 {cardinality="1", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I) [Term] id: UPa:UER00173 name: 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3 namespace: enzymatic_reaction def: "1 D-ribose 5-phosphate => 1 alpha-D-ribose 1-phosphate." [] xref: EC:5.4.2.7 xref: GO:0008973 "molecular_function:phosphopentomutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00117 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose 5-phosphate relationship: has_input_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00620 ! alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC00620 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00071 ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II) relationship: part_of UPa:ULS00071 {cardinality="1", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II) [Term] id: UPa:UER00174 name: 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 2/3 namespace: enzymatic_reaction def: "1 alpha-D-ribose 1-phosphate => 1 D-ribose 1,5-bisphosphate." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00620 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-ribose 1-phosphate relationship: has_input_compound UPa:UPC00620 ! alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC01151 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose 1,5-bisphosphate relationship: has_output_compound UPa:UPC01151 ! D-ribose 1,5-bisphosphate relationship: part_of UPa:ULS00071 ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II) relationship: part_of UPa:ULS00071 {cardinality="1", order="2"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II) [Term] id: UPa:UER00175 name: 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3 namespace: enzymatic_reaction def: "1 ATP + 1 D-ribose 1,5-bisphosphate => 1 5-phospho-alpha-D-ribose 1-diphosphate + 1 ADP." [] xref: EC:2.7.4.23 xref: GO:0033863 "molecular_function:ribose 1,5-bisphosphate phosphokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC01151 ! D-ribose 1,5-bisphosphate relationship: has_input_compound UPa:UPC01151 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose 1,5-bisphosphate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00071 ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II) relationship: part_of UPa:ULS00071 {cardinality="1", order="3"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II) [Term] id: UPa:UER00176 name: 3-dehydroquinate from D-quinate (NAD(+) route): step 1/1 namespace: enzymatic_reaction def: "1 D-quinate + 1 NAD(+) => 1 3-dehydroquinate + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.24 xref: GO:0030266 "molecular_function:quinate 3-dehydrogenase (NAD+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00296 ! D-quinate relationship: has_input_compound UPa:UPC00296 {cardinality="1", is_alternate="False", is_primary="True"} ! D-quinate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00944 ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00944 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroquinate relationship: part_of UPa:ULS00072 ! 3-dehydroquinate from D-quinate (NAD(+) route) relationship: part_of UPa:ULS00072 {cardinality="1", order="1"} ! 3-dehydroquinate from D-quinate (NAD(+) route) [Term] id: UPa:UER00177 name: 3-dehydroquinate from D-quinate (PQQ route): step 1/1 namespace: enzymatic_reaction def: "1 D-quinate + 1 pyrroloquinoline quinone => 1 3-dehydroquinate + 1 pyrroloquinoline quinol." [] xref: EC:1.1.5.8 xref: GO:0047519 "molecular_function:quinate dehydrogenase (quinone) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00113 ! pyrroloquinoline quinone relationship: has_input_compound UPa:UPC00113 {cardinality="1", is_alternate="False", is_primary="False"} ! pyrroloquinoline quinone relationship: has_input_compound UPa:UPC00296 ! D-quinate relationship: has_input_compound UPa:UPC00296 {cardinality="1", is_alternate="False", is_primary="True"} ! D-quinate relationship: has_output_compound UPa:UPC00944 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00944 ! 3-dehydroquinate relationship: has_output_compound UPa:UPC01359 {cardinality="1", is_alternate="False", is_primary="False"} ! pyrroloquinoline quinol relationship: has_output_compound UPa:UPC01359 ! pyrroloquinoline quinol relationship: part_of UPa:ULS00073 ! 3-dehydroquinate from D-quinate (PQQ route) relationship: part_of UPa:ULS00073 {cardinality="1", order="1"} ! 3-dehydroquinate from D-quinate (PQQ route) [Term] id: UPa:UER00178 name: 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2 namespace: enzymatic_reaction def: "1 3-dehydroquinate => 1 3-dehydroshikimate + 1 H(2)O." [] xref: EC:4.2.1.10 xref: GO:0003855 "molecular_function:3-dehydroquinate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00944 ! 3-dehydroquinate relationship: has_input_compound UPa:UPC00944 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC02637 ! 3-dehydroshikimate relationship: has_output_compound UPa:UPC02637 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroshikimate relationship: part_of UPa:ULS00074 ! 3,4-dihydroxybenzoate from 3-dehydroquinate relationship: part_of UPa:ULS00074 {cardinality="1", order="1"} ! 3,4-dihydroxybenzoate from 3-dehydroquinate [Term] id: UPa:UER00179 name: 3,4-dihydroxybenzoate from 3-dehydroquinate: step 2/2 namespace: enzymatic_reaction def: "1 3-dehydroshikimate => 1 3,4-dihydroxybenzoate + 1 H(2)O." [] xref: EC:4.2.1.118 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC02637 ! 3-dehydroshikimate relationship: has_input_compound UPa:UPC02637 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroshikimate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00230 {cardinality="1", is_alternate="False", is_primary="True"} ! 3,4-dihydroxybenzoate relationship: part_of UPa:ULS00074 ! 3,4-dihydroxybenzoate from 3-dehydroquinate relationship: part_of UPa:ULS00074 {cardinality="1", order="2"} ! 3,4-dihydroxybenzoate from 3-dehydroquinate [Term] id: UPa:UER00180 name: D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4 namespace: enzymatic_reaction def: "1 ATP + 1 D-glucose => 1 ADP + 1 D-glucose 6-phosphate." [] xref: EC:2.7.1.2 xref: GO:0004340 "molecular_function:glucokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00031 ! D-glucose relationship: has_input_compound UPa:UPC00031 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucose relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00092 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: part_of UPa:ULS00075 {cardinality="1", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose relationship: part_of UPa:ULS00075 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose [Term] id: UPa:UER00181 name: D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4 namespace: enzymatic_reaction def: "1 D-glucose 6-phosphate => 1 D-fructose 6-phosphate." [] xref: EC:5.3.1.9 xref: GO:0004347 "molecular_function:glucose-6-phosphate isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_input_compound UPa:UPC00092 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: part_of UPa:ULS00075 {cardinality="1", order="2"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose relationship: part_of UPa:ULS00075 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose [Term] id: UPa:UER00182 name: D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4 namespace: enzymatic_reaction def: "1 ATP + 1 D-fructose 6-phosphate => 1 ADP + 1 D-fructose 1,6-bisphosphate." [] xref: EC:2.7.1.11 xref: GO:0003872 "molecular_function:6-phosphofructokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00354 ! D-fructose 1,6-bisphosphate relationship: has_output_compound UPa:UPC00354 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 1,6-bisphosphate relationship: part_of UPa:ULS00075 {cardinality="1", order="3"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose relationship: part_of UPa:ULS00075 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose [Term] id: UPa:UER00183 name: D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4 namespace: enzymatic_reaction def: "1 D-fructose 1,6-bisphosphate => 1 D-glyceraldehyde 3-phosphate + 1 glycerone phosphate." [] xref: EC:4.1.2.13 xref: GO:0004332 "molecular_function:fructose-bisphosphate aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00354 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 1,6-bisphosphate relationship: has_input_compound UPa:UPC00354 ! D-fructose 1,6-bisphosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00075 {cardinality="1", order="4"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose relationship: part_of UPa:ULS00075 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose [Term] id: UPa:UER00184 name: pyruvate from D-glyceraldehyde 3-phosphate: step 1/5 namespace: enzymatic_reaction def: "1 D-glyceraldehyde 3-phosphate + 1 NAD(+) + 1 phosphate => 1 3-phospho-D-glyceroyl phosphate + 1 H(+) + 1 NADH." [] xref: EC:1.2.1.12 xref: GO:0004365 "molecular_function:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00236 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phospho-D-glyceroyl phosphate relationship: has_output_compound UPa:UPC00236 ! 3-phospho-D-glyceroyl phosphate relationship: part_of UPa:ULS00077 {cardinality="1", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00077 ! pyruvate from D-glyceraldehyde 3-phosphate [Term] id: UPa:UER00185 name: pyruvate from D-glyceraldehyde 3-phosphate: step 2/5 namespace: enzymatic_reaction def: "1 3-phospho-D-glyceroyl phosphate + 1 ADP => 1 3-phospho-D-glycerate + 1 ATP." [] xref: EC:2.7.2.3 xref: GO:0004618 "molecular_function:phosphoglycerate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_input_compound UPa:UPC00008 ! ADP relationship: has_input_compound UPa:UPC00236 ! 3-phospho-D-glyceroyl phosphate relationship: has_input_compound UPa:UPC00236 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phospho-D-glyceroyl phosphate relationship: has_output_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_output_compound UPa:UPC00002 ! ATP relationship: has_output_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00197 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phospho-D-glycerate relationship: part_of UPa:ULS00077 {cardinality="1", order="2"} ! pyruvate from D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00077 ! pyruvate from D-glyceraldehyde 3-phosphate [Term] id: UPa:UER00186 name: pyruvate from D-glyceraldehyde 3-phosphate: step 3/5 namespace: enzymatic_reaction def: "1 3-phospho-D-glycerate => 1 2-phospho-D-glycerate." [] xref: EC:5.4.2.11 xref: GO:0004619 "molecular_function:phosphoglycerate mutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: has_input_compound UPa:UPC00197 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00631 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-phospho-D-glycerate relationship: has_output_compound UPa:UPC00631 ! 2-phospho-D-glycerate relationship: part_of UPa:ULS00077 {cardinality="1", order="3"} ! pyruvate from D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00077 ! pyruvate from D-glyceraldehyde 3-phosphate [Term] id: UPa:UER00187 name: pyruvate from D-glyceraldehyde 3-phosphate: step 4/5 namespace: enzymatic_reaction def: "1 2-phospho-D-glycerate => 1 H(2)O + 1 phosphoenolpyruvate." [] xref: EC:4.2.1.11 xref: GO:0004634 "molecular_function:phosphopyruvate hydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00631 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-phospho-D-glycerate relationship: has_input_compound UPa:UPC00631 ! 2-phospho-D-glycerate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00074 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphoenolpyruvate relationship: has_output_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: part_of UPa:ULS00077 {cardinality="1", order="4"} ! pyruvate from D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00077 ! pyruvate from D-glyceraldehyde 3-phosphate [Term] id: UPa:UER00188 name: pyruvate from D-glyceraldehyde 3-phosphate: step 5/5 namespace: enzymatic_reaction def: "1 ADP + 1 phosphoenolpyruvate => 1 ATP + 1 pyruvate." [] xref: EC:2.7.1.40 xref: GO:0004743 "molecular_function:pyruvate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00008 ! ADP relationship: has_input_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_input_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00074 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphoenolpyruvate relationship: has_output_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_output_compound UPa:UPC00002 ! ATP relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: part_of UPa:ULS00077 {cardinality="1", order="5"} ! pyruvate from D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00077 ! pyruvate from D-glyceraldehyde 3-phosphate [Term] id: UPa:UER00189 name: D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1 namespace: enzymatic_reaction def: "1 glycerone phosphate => 1 D-glyceraldehyde 3-phosphate." [] xref: EC:5.3.1.1 xref: GO:0004807 "molecular_function:triose-phosphate isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerone phosphate relationship: has_input_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00076 {cardinality="1", order="1"} ! D-glyceraldehyde 3-phosphate from glycerone phosphate relationship: part_of UPa:ULS00076 ! D-glyceraldehyde 3-phosphate from glycerone phosphate [Term] id: UPa:UER00190 name: GDP-L-fucose from GDP-alpha-D-mannose: step 1/2 namespace: enzymatic_reaction def: "1 GDP-alpha-D-mannose => 1 GDP-4-dehydro-6-deoxy-D-mannose + 1 H(2)O." [] xref: EC:4.2.1.47 xref: GO:0008446 "molecular_function:GDP-mannose 4,6-dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00096 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC01222 ! GDP-4-dehydro-6-deoxy-D-mannose relationship: has_output_compound UPa:UPC01222 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-4-dehydro-6-deoxy-D-mannose relationship: part_of UPa:ULS00078 ! GDP-L-fucose from GDP-alpha-D-mannose relationship: part_of UPa:ULS00078 {cardinality="1", order="1"} ! GDP-L-fucose from GDP-alpha-D-mannose [Term] id: UPa:UER00191 name: GDP-L-fucose from GDP-alpha-D-mannose: step 2/2 namespace: enzymatic_reaction def: "1 GDP-4-dehydro-6-deoxy-D-mannose + 1 H(+) + 1 NADPH => 1 GDP-L-fucose + 1 NADP(+)." [] xref: EC:1.1.1.271 xref: GO:0050577 "molecular_function:GDP-L-fucose synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01222 ! GDP-4-dehydro-6-deoxy-D-mannose relationship: has_input_compound UPa:UPC01222 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-4-dehydro-6-deoxy-D-mannose relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00325 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-L-fucose relationship: has_output_compound UPa:UPC00325 ! GDP-L-fucose relationship: part_of UPa:ULS00078 ! GDP-L-fucose from GDP-alpha-D-mannose relationship: part_of UPa:ULS00078 {cardinality="1", order="2"} ! GDP-L-fucose from GDP-alpha-D-mannose [Term] id: UPa:UER00192 name: 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 1/2 namespace: enzymatic_reaction def: "1 3-phospho-D-glycerate + 1 GDP-alpha-D-mannose => 1 2-(alpha-D-mannosyl)-3-phosphoglyceric acid + 1 GDP." [] xref: EC:2.4.1.217 xref: GO:0050504 "molecular_function:mannosyl-3-phosphoglycerate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00096 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00197 {cardinality="1", is_alternate="False", is_primary="False"} ! 3-phospho-D-glycerate relationship: has_input_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00035 ! GDP relationship: has_output_compound UPa:UPC00035 {cardinality="1", is_alternate="False", is_primary="False"} ! GDP relationship: has_output_compound UPa:UPC11516 ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid relationship: has_output_compound UPa:UPC11516 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid relationship: part_of UPa:ULS00079 ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route) relationship: part_of UPa:ULS00079 {cardinality="1", order="1"} ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route) [Term] id: UPa:UER00193 name: 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 2/2 namespace: enzymatic_reaction def: "1 2-(alpha-D-mannosyl)-3-phosphoglyceric acid + 1 H(2)O => 1 2-(alpha-D-mannosyl)-D-glycerate + 1 phosphate." [] xref: EC:3.1.3.70 xref: GO:0050531 "molecular_function:mannosyl-3-phosphoglycerate phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC11516 ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid relationship: has_input_compound UPa:UPC11516 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC11544 ! 2-(alpha-D-mannosyl)-D-glycerate relationship: has_output_compound UPa:UPC11544 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-(alpha-D-mannosyl)-D-glycerate relationship: part_of UPa:ULS00079 ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route) relationship: part_of UPa:ULS00079 {cardinality="1", order="2"} ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route) [Term] id: UPa:UER00194 name: L-asparagine from L-aspartate (ammonia route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 L-aspartate + 1 NH(3) => 1 AMP + 1 L-asparagine + 1 diphosphate." [] xref: EC:6.3.1.1 xref: GO:0004071 "molecular_function:aspartate-ammonia ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00152 {cardinality="1", is_alternate="False", is_primary="True"} ! L-asparagine relationship: has_output_compound UPa:UPC00152 ! L-asparagine relationship: part_of UPa:ULS00080 ! L-asparagine from L-aspartate (ammonia route) relationship: part_of UPa:ULS00080 {cardinality="1", order="1"} ! L-asparagine from L-aspartate (ammonia route) [Term] id: UPa:UER00195 name: L-asparagine from L-aspartate (L-Gln route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 H(2)O + 1 L-aspartate + 1 L-glutamine => 1 AMP + 1 L-asparagine + 1 L-glutamate + 1 diphosphate." [] xref: EC:6.3.5.4 xref: GO:0004066 "molecular_function:asparagine synthase (glutamine-hydrolyzing) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00152 {cardinality="1", is_alternate="False", is_primary="True"} ! L-asparagine relationship: has_output_compound UPa:UPC00152 ! L-asparagine relationship: part_of UPa:ULS00081 ! L-asparagine from L-aspartate (L-Gln route) relationship: part_of UPa:ULS00081 {cardinality="1", order="1"} ! L-asparagine from L-aspartate (L-Gln route) [Term] id: UPa:UER00196 name: L-serine from 3-phospho-D-glycerate: step 1/3 namespace: enzymatic_reaction def: "1 3-phospho-D-glycerate + 1 NAD(+) => 1 3-phosphohydroxypyruvate + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.95 xref: GO:0004617 "molecular_function:phosphoglycerate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: has_input_compound UPa:UPC00197 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC03232 ! 3-phosphohydroxypyruvate relationship: has_output_compound UPa:UPC03232 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phosphohydroxypyruvate relationship: part_of UPa:ULS00082 ! L-serine from 3-phospho-D-glycerate relationship: part_of UPa:ULS00082 {cardinality="1", order="1"} ! L-serine from 3-phospho-D-glycerate [Term] id: UPa:UER00197 name: L-serine from 3-phospho-D-glycerate: step 2/3 namespace: enzymatic_reaction def: "1 3-phosphohydroxypyruvate + 1 L-glutamate => 1 2-oxoglutarate + 1 O-phospho-L-serine." [] xref: EC:2.6.1.52 xref: GO:0004648 "molecular_function:O-phospho-L-serine:2-oxoglutarate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC03232 ! 3-phosphohydroxypyruvate relationship: has_input_compound UPa:UPC03232 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phosphohydroxypyruvate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC01005 ! O-phospho-L-serine relationship: has_output_compound UPa:UPC01005 {cardinality="1", is_alternate="False", is_primary="True"} ! O-phospho-L-serine relationship: part_of UPa:ULS00082 ! L-serine from 3-phospho-D-glycerate relationship: part_of UPa:ULS00082 {cardinality="1", order="2"} ! L-serine from 3-phospho-D-glycerate [Term] id: UPa:UER00198 name: L-serine from 3-phospho-D-glycerate: step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 O-phospho-L-serine => 1 L-serine + 1 phosphate." [] xref: EC:3.1.3.3 xref: GO:0004647 "molecular_function:phosphoserine phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC01005 ! O-phospho-L-serine relationship: has_input_compound UPa:UPC01005 {cardinality="1", is_alternate="False", is_primary="True"} ! O-phospho-L-serine relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00065 ! L-serine relationship: has_output_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="True"} ! L-serine relationship: part_of UPa:ULS00082 ! L-serine from 3-phospho-D-glycerate relationship: part_of UPa:ULS00082 {cardinality="1", order="3"} ! L-serine from 3-phospho-D-glycerate [Term] id: UPa:UER00199 name: L-cysteine from L-serine: step 1/2 namespace: enzymatic_reaction def: "1 L-serine + 1 acetyl-CoA => 1 CoA + 1 O-acetyl-L-serine." [] xref: EC:2.3.1.30 xref: GO:0009001 "molecular_function:serine O-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="True"} ! L-serine relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00979 ! O-acetyl-L-serine relationship: has_output_compound UPa:UPC00979 {cardinality="1", is_alternate="False", is_primary="True"} ! O-acetyl-L-serine relationship: part_of UPa:ULS00083 ! L-cysteine from L-serine relationship: part_of UPa:ULS00083 {cardinality="1", order="1"} ! L-cysteine from L-serine [Term] id: UPa:UER00200 name: L-cysteine from L-serine: step 2/2 namespace: enzymatic_reaction def: "1 O-acetyl-L-serine + 1 hydrogen sulfide => 1 L-cysteine + 1 acetate." [] xref: EC:2.5.1.47 xref: GO:0004124 "molecular_function:cysteine synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00283 {cardinality="1", is_alternate="False", is_primary="False"} ! hydrogen sulfide relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_input_compound UPa:UPC00979 ! O-acetyl-L-serine relationship: has_input_compound UPa:UPC00979 {cardinality="1", is_alternate="False", is_primary="True"} ! O-acetyl-L-serine relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC00097 ! L-cysteine relationship: has_output_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cysteine relationship: part_of UPa:ULS00083 ! L-cysteine from L-serine relationship: part_of UPa:ULS00083 {cardinality="1", order="2"} ! L-cysteine from L-serine [Term] id: UPa:UER00201 name: L-cysteine from L-homocysteine and L-serine: step 1/2 namespace: enzymatic_reaction def: "1 L-homocysteine + 1 L-serine => 1 H(2)O + 1 L-cystathionine." [] xref: EC:4.2.1.22 xref: GO:0004122 "molecular_function:cystathionine beta-synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="True"} ! L-serine relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_input_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC02291 ! L-cystathionine relationship: has_output_compound UPa:UPC02291 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cystathionine relationship: part_of UPa:ULS00084 ! L-cysteine from L-homocysteine and L-serine relationship: part_of UPa:ULS00084 {cardinality="1", order="1"} ! L-cysteine from L-homocysteine and L-serine [Term] id: UPa:UER00202 name: L-cysteine from L-homocysteine and L-serine: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-cystathionine => 1 2-oxobutanoate + 1 L-cysteine + 1 NH(3)." [] xref: EC:4.4.1.1 xref: GO:0004123 "molecular_function:cystathionine gamma-lyase activity" xref: GO:0044540 "molecular_function:L-cystine L-cysteine-lyase (deaminating)" xref: GO:0080146 "molecular_function:L-cysteine desulfhydrase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC02291 ! L-cystathionine relationship: has_input_compound UPa:UPC02291 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cystathionine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00097 ! L-cysteine relationship: has_output_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cysteine relationship: has_output_compound UPa:UPC00109 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00109 ! 2-oxobutanoate relationship: part_of UPa:ULS00084 ! L-cysteine from L-homocysteine and L-serine relationship: part_of UPa:ULS00084 {cardinality="1", order="2"} ! L-cysteine from L-homocysteine and L-serine [Term] id: UPa:UER00203 name: prephenate from chorismate: step 1/1 namespace: enzymatic_reaction def: "1 chorismate => 1 prephenate." [] xref: EC:5.4.99.5 xref: GO:0004106 "molecular_function:chorismate mutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00251 {cardinality="1", is_alternate="False", is_primary="True"} ! chorismate relationship: has_input_compound UPa:UPC00251 ! chorismate relationship: has_output_compound UPa:UPC00254 ! prephenate relationship: has_output_compound UPa:UPC00254 {cardinality="1", is_alternate="False", is_primary="True"} ! prephenate relationship: part_of UPa:ULS00085 ! prephenate from chorismate relationship: part_of UPa:ULS00085 {cardinality="1", order="1"} ! prephenate from chorismate [Term] id: UPa:UER00204 name: sulfite from sulfate: step 1/3 namespace: enzymatic_reaction def: "1 ATP + 1 sulfate => 1 5'-adenylyl sulfate + 1 diphosphate." [] xref: EC:2.7.7.4 xref: GO:0004781 "molecular_function:sulfate adenylyltransferase (ATP) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00059 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfate relationship: has_input_compound UPa:UPC00059 ! sulfate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00224 ! 5'-adenylyl sulfate relationship: has_output_compound UPa:UPC00224 {cardinality="1", is_alternate="False", is_primary="True"} ! 5'-adenylyl sulfate relationship: part_of UPa:ULS00086 ! sulfite from sulfate relationship: part_of UPa:ULS00086 {cardinality="1", order="1"} ! sulfite from sulfate [Term] id: UPa:UER00205 name: sulfite from sulfate: step 2/3 namespace: enzymatic_reaction def: "1 5'-adenylyl sulfate + 1 ATP => 1 3'-phospho-5'-adenylyl sulfate + 1 ADP." [] xref: EC:2.7.1.25 xref: GO:0004020 "molecular_function:adenylylsulfate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00224 {cardinality="1", is_alternate="False", is_primary="True"} ! 5'-adenylyl sulfate relationship: has_input_compound UPa:UPC00224 ! 5'-adenylyl sulfate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00053 ! 3'-phospho-5'-adenylyl sulfate relationship: has_output_compound UPa:UPC00053 {cardinality="1", is_alternate="False", is_primary="True"} ! 3'-phospho-5'-adenylyl sulfate relationship: part_of UPa:ULS00086 ! sulfite from sulfate relationship: part_of UPa:ULS00086 {cardinality="1", order="2"} ! sulfite from sulfate [Term] id: UPa:UER00206 name: sulfite from sulfate: step 3/3 namespace: enzymatic_reaction def: "1 3'-phospho-5'-adenylyl sulfate + 1 thioredoxin => 1 adenosine 3',5'-bisphosphate + 1 sulfite + 1 thioredoxin disulfide." [] xref: EC:1.8.4.8 xref: GO:0004604 "molecular_function:phosphoadenylyl-sulfate reductase (thioredoxin) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00053 ! 3'-phospho-5'-adenylyl sulfate relationship: has_input_compound UPa:UPC00053 {cardinality="1", is_alternate="False", is_primary="True"} ! 3'-phospho-5'-adenylyl sulfate relationship: has_input_compound UPa:UPC00342 {cardinality="1", is_alternate="False", is_primary="False"} ! thioredoxin relationship: has_input_compound UPa:UPC00342 ! thioredoxin relationship: has_output_compound UPa:UPC00054 ! adenosine 3',5'-bisphosphate relationship: has_output_compound UPa:UPC00054 {cardinality="1", is_alternate="False", is_primary="False"} ! adenosine 3',5'-bisphosphate relationship: has_output_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC00094 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfite relationship: has_output_compound UPa:UPC00343 {cardinality="1", is_alternate="False", is_primary="False"} ! thioredoxin disulfide relationship: has_output_compound UPa:UPC00343 ! thioredoxin disulfide relationship: part_of UPa:ULS00086 ! sulfite from sulfate relationship: part_of UPa:ULS00086 {cardinality="1", order="3"} ! sulfite from sulfate [Term] id: UPa:UER00207 name: hydrogen sulfide from sulfite (NADPH route): step 1/1 namespace: enzymatic_reaction def: "3 H(+) + 3 NADPH + 1 sulfite => 3 H(2)O + 3 NADP(+) + 1 hydrogen sulfide." [] xref: EC:1.8.1.2 xref: GO:0004783 "molecular_function:sulfite reductase (NADPH) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00094 ! sulfite relationship: has_input_compound UPa:UPC00094 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfite relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_output_compound UPa:UPC00283 {cardinality="1", is_alternate="False", is_primary="True"} ! hydrogen sulfide relationship: part_of UPa:ULS00087 ! hydrogen sulfide from sulfite (NADPH route) relationship: part_of UPa:ULS00087 {cardinality="1", order="1"} ! hydrogen sulfide from sulfite (NADPH route) [Term] id: UPa:UER00208 name: hydrogen sulfide from sulfite (ferredoxin route): step 1/1 namespace: enzymatic_reaction def: "6 H(+) + 6 reduced ferredoxin + 1 sulfite => 3 H(2)O + 1 hydrogen sulfide + 6 oxidized ferredoxin." [] xref: EC:1.8.7.1 xref: GO:0050311 "molecular_function:sulfite reductase (ferredoxin) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00094 ! sulfite relationship: has_input_compound UPa:UPC00094 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfite relationship: has_input_compound UPa:UPC00138 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced ferredoxin relationship: has_input_compound UPa:UPC00138 ! reduced ferredoxin relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00139 {cardinality="1", is_alternate="False", is_primary="False"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00139 ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_output_compound UPa:UPC00283 {cardinality="1", is_alternate="False", is_primary="True"} ! hydrogen sulfide relationship: part_of UPa:ULS00088 ! hydrogen sulfide from sulfite (ferredoxin route) relationship: part_of UPa:ULS00088 {cardinality="1", order="1"} ! hydrogen sulfide from sulfite (ferredoxin route) [Term] id: UPa:UER00209 name: glutathione from L-cysteine and L-glutamate: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 L-cysteine + 1 L-glutamate => 1 ADP + 1 L-gamma-glutamyl-L-cysteine + 1 phosphate." [] xref: EC:6.3.2.2 xref: GO:0004357 "molecular_function:glutamate-cysteine ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cysteine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00669 ! L-gamma-glutamyl-L-cysteine relationship: has_output_compound UPa:UPC00669 {cardinality="1", is_alternate="False", is_primary="True"} ! L-gamma-glutamyl-L-cysteine relationship: part_of UPa:ULS00089 ! glutathione from L-cysteine and L-glutamate relationship: part_of UPa:ULS00089 {cardinality="1", order="1"} ! glutathione from L-cysteine and L-glutamate [Term] id: UPa:UER00210 name: glutathione from L-cysteine and L-glutamate: step 2/2 namespace: enzymatic_reaction def: "1 ATP + 1 L-gamma-glutamyl-L-cysteine + 1 glycine => 1 ADP + 1 glutathione + 1 phosphate." [] xref: EC:6.3.2.3 xref: GO:0004363 "molecular_function:glutathione synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="False"} ! glycine relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00669 ! L-gamma-glutamyl-L-cysteine relationship: has_input_compound UPa:UPC00669 {cardinality="1", is_alternate="False", is_primary="True"} ! L-gamma-glutamyl-L-cysteine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00051 {cardinality="1", is_alternate="False", is_primary="True"} ! glutathione relationship: has_output_compound UPa:UPC00051 ! glutathione relationship: part_of UPa:ULS00089 {cardinality="1", order="2"} ! glutathione from L-cysteine and L-glutamate relationship: part_of UPa:ULS00089 ! glutathione from L-cysteine and L-glutamate [Term] id: UPa:UER00211 name: precorrin-2 from uroporphyrinogen III: step 1/1 namespace: enzymatic_reaction def: "2 S-adenosyl-L-methionine + 1 uroporphyrinogen III => 2 S-adenosyl-L-homocysteine + 1 precorrin-2." [] xref: EC:2.1.1.107 xref: GO:0004851 "molecular_function:uroporphyrin-III C-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01051 {cardinality="1", is_alternate="False", is_primary="True"} ! uroporphyrinogen III relationship: has_input_compound UPa:UPC01051 ! uroporphyrinogen III relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC02463 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-2 relationship: has_output_compound UPa:UPC02463 ! precorrin-2 relationship: part_of UPa:ULS00090 ! precorrin-2 from uroporphyrinogen III relationship: part_of UPa:ULS00090 {cardinality="1", order="1"} ! precorrin-2 from uroporphyrinogen III [Term] id: UPa:UER00212 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 1/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 precorrin-2 => 1 H(+) + 1 S-adenosyl-L-homocysteine + 1 precorrin-3A." [] xref: EC:2.1.1.130 xref: GO:0030788 "molecular_function:precorrin-2 C20-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC02463 ! precorrin-2 relationship: has_input_compound UPa:UPC02463 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-2 relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC05772 ! precorrin-3A relationship: has_output_compound UPa:UPC05772 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-3A relationship: part_of UPa:ULS00091 {cardinality="1", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) relationship: part_of UPa:ULS00091 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00213 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 2/10 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 precorrin-3A => 1 H(2)O + 1 NAD(+) + 1 precorrin-3B." [] xref: EC:1.14.13.83 xref: GO:0043818 "molecular_function:precorrin-3B synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC05772 ! precorrin-3A relationship: has_input_compound UPa:UPC05772 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-3A relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC06406 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-3B relationship: has_output_compound UPa:UPC06406 ! precorrin-3B relationship: part_of UPa:ULS00091 {cardinality="1", order="2"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) relationship: part_of UPa:ULS00091 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00214 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 3/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 precorrin-3B => 1 S-adenosyl-L-homocysteine + 1 precorrin-4." [] xref: EC:2.1.1.131 xref: GO:0030789 "molecular_function:precorrin-3B C17-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06406 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-3B relationship: has_input_compound UPa:UPC06406 ! precorrin-3B relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06407 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-4 relationship: has_output_compound UPa:UPC06407 ! precorrin-4 relationship: part_of UPa:ULS00091 {cardinality="1", order="3"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) relationship: part_of UPa:ULS00091 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00215 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 4/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 precorrin-4 => 1 S-adenosyl-L-homocysteine + 1 precorrin-5." [] xref: EC:2.1.1.133 xref: GO:0046026 "molecular_function:precorrin-4 C11-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06407 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-4 relationship: has_input_compound UPa:UPC06407 ! precorrin-4 relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06416 ! precorrin-5 relationship: has_output_compound UPa:UPC06416 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-5 relationship: part_of UPa:ULS00091 {cardinality="1", order="4"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) relationship: part_of UPa:ULS00091 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00216 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 5/10 namespace: enzymatic_reaction def: "1 H(2)O + 1 S-adenosyl-L-methionine + 1 precorrin-5 => 1 S-adenosyl-L-homocysteine + 1 acetate + 1 precorrin-6A." [] xref: EC:2.1.1.152 xref: GO:0043819 "molecular_function:precorrin-6A synthase (deacetylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06416 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-5 relationship: has_input_compound UPa:UPC06416 ! precorrin-5 relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC06320 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-6A relationship: has_output_compound UPa:UPC06320 ! precorrin-6A relationship: part_of UPa:ULS00091 {cardinality="1", order="5"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) relationship: part_of UPa:ULS00091 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00217 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 6/10 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 precorrin-6A => 1 NADP(+) + 1 precorrin-6B." [] xref: EC:1.3.1.54 xref: GO:0016994 "molecular_function:precorrin-6A reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC06320 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-6A relationship: has_input_compound UPa:UPC06320 ! precorrin-6A relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC06319 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-6B relationship: has_output_compound UPa:UPC06319 ! precorrin-6B relationship: part_of UPa:ULS00091 {cardinality="1", order="6"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) relationship: part_of UPa:ULS00091 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00218 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 7/10 namespace: enzymatic_reaction def: "2 S-adenosyl-L-methionine + 1 precorrin-6B => 1 CO(2) + 2 S-adenosyl-L-homocysteine + 1 precorrin-8X." [] xref: EC:2.1.1.132 xref: GO:0046025 "molecular_function:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06319 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-6B relationship: has_input_compound UPa:UPC06319 ! precorrin-6B relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06408 ! precorrin-8X relationship: has_output_compound UPa:UPC06408 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-8X relationship: part_of UPa:ULS00091 {cardinality="1", order="7"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) relationship: part_of UPa:ULS00091 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00219 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 8/10 namespace: enzymatic_reaction def: "1 precorrin-8X => 1 hydrogenobyrinic acid." [] xref: EC:5.4.99.61 xref: GO:0016993 "molecular_function:precorrin-8X methylmutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC06408 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-8X relationship: has_input_compound UPa:UPC06408 ! precorrin-8X relationship: has_output_compound UPa:UPC06399 {cardinality="1", is_alternate="False", is_primary="True"} ! hydrogenobyrinic acid relationship: has_output_compound UPa:UPC06399 ! hydrogenobyrinic acid relationship: part_of UPa:ULS00091 {cardinality="1", order="8"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) relationship: part_of UPa:ULS00091 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00220 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10 namespace: enzymatic_reaction def: "2 ATP + 2 H(2)O + 2 L-glutamine + 1 hydrogenobyrinic acid => 2 ADP + 2 L-glutamate + 1 hydrogenobyrinic acid a,c-diamide + 2 phosphate." [] xref: EC:6.3.5.9 xref: GO:0043802 "molecular_function:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC06399 {cardinality="1", is_alternate="False", is_primary="True"} ! hydrogenobyrinic acid relationship: has_input_compound UPa:UPC06399 ! hydrogenobyrinic acid relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC06503 {cardinality="1", is_alternate="False", is_primary="True"} ! hydrogenobyrinic acid a,c-diamide relationship: has_output_compound UPa:UPC06503 ! hydrogenobyrinic acid a,c-diamide relationship: part_of UPa:ULS00091 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) relationship: part_of UPa:ULS00091 {cardinality="1", order="9"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00221 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 10/10 namespace: enzymatic_reaction def: "1 ATP + 1 Co(2+) + 1 H(2)O + 1 hydrogenobyrinic acid a,c-diamide => 1 ADP + 1 H(+) + 1 cob(II)yrinate a,c-diamide + 1 phosphate." [] xref: EC:6.6.1.2 xref: GO:0051116 "molecular_function:cobaltochelatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00175 {cardinality="1", is_alternate="False", is_primary="False"} ! Co(2+) relationship: has_input_compound UPa:UPC00175 ! Co(2+) relationship: has_input_compound UPa:UPC06503 ! hydrogenobyrinic acid a,c-diamide relationship: has_input_compound UPa:UPC06503 {cardinality="1", is_alternate="False", is_primary="True"} ! hydrogenobyrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC06504 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(II)yrinate a,c-diamide relationship: has_output_compound UPa:UPC06504 ! cob(II)yrinate a,c-diamide relationship: part_of UPa:ULS00091 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) relationship: part_of UPa:ULS00091 {cardinality="1", order="10"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00222 name: sirohydrochlorin from precorrin-2: step 1/1 namespace: enzymatic_reaction def: "1 NAD(+) + 1 precorrin-2 => 1 H(+) + 1 NADH + 1 sirohydrochlorin." [] xref: EC:1.3.1.76 xref: GO:0043115 "molecular_function:precorrin-2 dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC02463 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-2 relationship: has_input_compound UPa:UPC02463 ! precorrin-2 relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC05778 {cardinality="1", is_alternate="False", is_primary="True"} ! sirohydrochlorin relationship: has_output_compound UPa:UPC05778 ! sirohydrochlorin relationship: part_of UPa:ULS00173 {cardinality="1", order="1"} ! sirohydrochlorin from precorrin-2 relationship: part_of UPa:ULS00173 ! sirohydrochlorin from precorrin-2 [Term] id: UPa:UER00223 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 1/10 namespace: enzymatic_reaction def: "1 Co(2+) + 1 sirohydrochlorin => 2 H(+) + 1 cobalt-precorrin-2." [] xref: EC:4.99.1.3 xref: GO:0016852 "molecular_function:sirohydrochlorin cobaltochelatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00175 {cardinality="1", is_alternate="False", is_primary="False"} ! Co(2+) relationship: has_input_compound UPa:UPC00175 ! Co(2+) relationship: has_input_compound UPa:UPC05778 ! sirohydrochlorin relationship: has_input_compound UPa:UPC05778 {cardinality="1", is_alternate="False", is_primary="True"} ! sirohydrochlorin relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC11538 ! cobalt-precorrin-2 relationship: has_output_compound UPa:UPC11538 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin-2 relationship: part_of UPa:ULS00092 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) relationship: part_of UPa:ULS00092 {cardinality="1", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00224 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 2/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 cobalt-precorrin-2 => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 3." [] xref: EC:2.1.1.151 xref: GO:0043781 "molecular_function:cobalt-factor II C20-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11538 ! cobalt-precorrin-2 relationship: has_input_compound UPa:UPC11538 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin-2 relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11539 ! cobalt-precorrin 3 relationship: has_output_compound UPa:UPC11539 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 3 relationship: part_of UPa:ULS00092 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) relationship: part_of UPa:ULS00092 {cardinality="1", order="2"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00225 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 3/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 cobalt-precorrin 3 => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 4." [] xref: EC:2.1.1 xref: GO:0000179 "molecular_function:rRNA (adenine-N6,N6-)-dimethyltransferase activity" xref: GO:0003880 "molecular_function:protein C-terminal carboxyl O-methyltransferase activity" xref: GO:0004809 "molecular_function:tRNA (guanine-N2-)-methyltransferase activity" xref: GO:0008168 "molecular_function:methyltransferase activity" xref: GO:0008169 "molecular_function:C-methyltransferase activity" xref: GO:0008170 "molecular_function:N-methyltransferase activity" xref: GO:0008171 "molecular_function:O-methyltransferase activity" xref: GO:0008172 "molecular_function:S-methyltransferase activity" xref: GO:0008173 "molecular_function:RNA methyltransferase activity" xref: GO:0008174 "molecular_function:mRNA methyltransferase activity" xref: GO:0008175 "molecular_function:tRNA methyltransferase activity" xref: GO:0008276 "molecular_function:protein methyltransferase activity" xref: GO:0008425 "molecular_function:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" xref: GO:0008649 "molecular_function:rRNA methyltransferase activity" xref: GO:0008650 "molecular_function:rRNA (uridine-2'-O-)-methyltransferase activity" xref: GO:0008988 "molecular_function:rRNA (adenine-N6-)-methyltransferase activity" xref: GO:0009008 "molecular_function:DNA-methyltransferase activity" xref: GO:0009019 "molecular_function:tRNA (guanine-N1-)-methyltransferase activity" xref: GO:0009383 "molecular_function:rRNA (cytosine-C5-)-methyltransferase activity" xref: GO:0016205 "molecular_function:selenocysteine methyltransferase activity" xref: GO:0016273 "molecular_function:arginine N-methyltransferase activity" xref: GO:0016274 "molecular_function:protein-arginine N-methyltransferase activity" xref: GO:0016278 "molecular_function:lysine N-methyltransferase activity" xref: GO:0016279 "molecular_function:protein-lysine N-methyltransferase activity" xref: GO:0016300 "molecular_function:tRNA (uracil) methyltransferase activity" xref: GO:0016423 "molecular_function:tRNA (guanine) methyltransferase activity" xref: GO:0016426 "molecular_function:tRNA (adenine) methyltransferase activity" xref: GO:0016427 "molecular_function:tRNA (cytosine) methyltransferase activity" xref: GO:0016428 "molecular_function:tRNA (cytosine-5-)-methyltransferase activity" xref: GO:0016429 "molecular_function:tRNA (adenine-N1-)-methyltransferase activity" xref: GO:0016433 "molecular_function:rRNA (adenine) methyltransferase activity" xref: GO:0016434 "molecular_function:rRNA (cytosine) methyltransferase activity" xref: GO:0016435 "molecular_function:rRNA (guanine) methyltransferase activity" xref: GO:0016436 "molecular_function:rRNA (uridine) methyltransferase activity" xref: GO:0018423 "molecular_function:protein C-terminal leucine carboxyl O-methyltransferase activity" xref: GO:0018707 "molecular_function:1-phenanthrol methyltransferase activity" xref: GO:0019702 "molecular_function:protein-arginine N5-methyltransferase activity" xref: GO:0030792 "molecular_function:methylarsonite methyltransferase activity" xref: GO:0034541 "molecular_function:dimethylarsinite methyltransferase activity" xref: GO:0034807 "molecular_function:4,5-dihydroxybenzo(a)pyrene methyltransferase activity" xref: GO:0034931 "molecular_function:1-hydroxypyrene methyltransferase activity" xref: GO:0034933 "molecular_function:1-hydroxy-6-methoxypyrene methyltransferase activity" xref: GO:0043770 "molecular_function:demethylmenaquinone methyltransferase activity" xref: GO:0043776 "molecular_function:cobalt-precorrin-6B C5-methyltransferase activity" xref: GO:0043777 "molecular_function:cobalt-precorrin-7 C15-methyltransferase activity" xref: GO:0043780 "molecular_function:cobalt-precorrin-5B C1-methyltransferase activity" xref: GO:0043782 "molecular_function:cobalt-precorrin-3 C17-methyltransferase activity" xref: GO:0043791 "molecular_function:dimethylamine methyltransferase activity" xref: GO:0043803 "molecular_function:hydroxyneurosporene-O-methyltransferase activity" xref: GO:0043827 "molecular_function:tRNA (adenine-57, 58-N(1)-) methyltransferase activity" xref: GO:0043833 "molecular_function:methylamine-specific methylcobalamin:coenzyme M methyltransferase activity" xref: GO:0043834 "molecular_function:trimethylamine methyltransferase activity" xref: GO:0043851 "molecular_function:methanol-specific methylcobalamin:coenzyme M methyltransferase activity" xref: GO:0043852 "molecular_function:monomethylamine methyltransferase activity" xref: GO:0051994 "molecular_function:P-methyltransferase activity" xref: GO:0051995 "molecular_function:Se-methyltransferase activity" xref: GO:0052624 "molecular_function:2-phytyl-1,4-naphthoquinone methyltransferase activity" xref: GO:0052665 "molecular_function:tRNA (uracil-2'-O-)-methyltransferase activity" xref: GO:0052666 "molecular_function:tRNA (cytosine-2'-O-)-methyltransferase activity" xref: GO:0052667 "molecular_function:phosphomethylethanolamine N-methyltransferase activity" xref: GO:0052735 "molecular_function:tRNA (cytosine-3-)-methyltransferase activity" xref: GO:0070677 "molecular_function:rRNA (cytosine-2'-O-)-methyltransferase activity" xref: GO:0071424 "molecular_function:rRNA (cytosine-N4-)-methyltransferase activity" xref: GO:0080012 "molecular_function:trihydroxyferuloyl spermidine O-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11539 ! cobalt-precorrin 3 relationship: has_input_compound UPa:UPC11539 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 3 relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11540 ! cobalt-precorrin 4 relationship: has_output_compound UPa:UPC11540 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 4 relationship: part_of UPa:ULS00092 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) relationship: part_of UPa:ULS00092 {cardinality="1", order="3"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00226 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 4/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 cobalt-precorrin 4 => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 5A." [] xref: EC:2.1.1.271 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11540 ! cobalt-precorrin 4 relationship: has_input_compound UPa:UPC11540 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 4 relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC16242 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 5A relationship: has_output_compound UPa:UPC16242 ! cobalt-precorrin 5A relationship: part_of UPa:ULS00092 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) relationship: part_of UPa:ULS00092 {cardinality="1", order="4"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00227 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 cobalt-precorrin 5B => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin-6A." [] xref: EC:2.1.1.195 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC16243 ! cobalt-precorrin 5B relationship: has_input_compound UPa:UPC16243 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 5B relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11542 ! cobalt-precorrin-6A relationship: has_output_compound UPa:UPC11542 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin-6A relationship: part_of UPa:ULS00092 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) relationship: part_of UPa:ULS00092 {cardinality="1", order="6"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00228 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 7/10 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 cobalt-precorrin-6A => 1 NAD(+) + 1 cobalt-precorrin-6B." [] xref: EC:1.3.1.106 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC11542 ! cobalt-precorrin-6A relationship: has_input_compound UPa:UPC11542 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin-6A relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC11543 ! cobalt-precorrin-6B relationship: has_output_compound UPa:UPC11543 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin-6B relationship: part_of UPa:ULS00092 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) relationship: part_of UPa:ULS00092 {cardinality="1", order="7"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00229 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10 namespace: enzymatic_reaction def: "2 S-adenosyl-L-methionine + 1 cobalt-precorrin-6B => 1 CO(2) + 2 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 8." [] xref: EC:2.1.1 xref: GO:0000179 "molecular_function:rRNA (adenine-N6,N6-)-dimethyltransferase activity" xref: GO:0003880 "molecular_function:protein C-terminal carboxyl O-methyltransferase activity" xref: GO:0004809 "molecular_function:tRNA (guanine-N2-)-methyltransferase activity" xref: GO:0008168 "molecular_function:methyltransferase activity" xref: GO:0008169 "molecular_function:C-methyltransferase activity" xref: GO:0008170 "molecular_function:N-methyltransferase activity" xref: GO:0008171 "molecular_function:O-methyltransferase activity" xref: GO:0008172 "molecular_function:S-methyltransferase activity" xref: GO:0008173 "molecular_function:RNA methyltransferase activity" xref: GO:0008174 "molecular_function:mRNA methyltransferase activity" xref: GO:0008175 "molecular_function:tRNA methyltransferase activity" xref: GO:0008276 "molecular_function:protein methyltransferase activity" xref: GO:0008425 "molecular_function:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" xref: GO:0008649 "molecular_function:rRNA methyltransferase activity" xref: GO:0008650 "molecular_function:rRNA (uridine-2'-O-)-methyltransferase activity" xref: GO:0008988 "molecular_function:rRNA (adenine-N6-)-methyltransferase activity" xref: GO:0009008 "molecular_function:DNA-methyltransferase activity" xref: GO:0009019 "molecular_function:tRNA (guanine-N1-)-methyltransferase activity" xref: GO:0009383 "molecular_function:rRNA (cytosine-C5-)-methyltransferase activity" xref: GO:0016205 "molecular_function:selenocysteine methyltransferase activity" xref: GO:0016273 "molecular_function:arginine N-methyltransferase activity" xref: GO:0016274 "molecular_function:protein-arginine N-methyltransferase activity" xref: GO:0016278 "molecular_function:lysine N-methyltransferase activity" xref: GO:0016279 "molecular_function:protein-lysine N-methyltransferase activity" xref: GO:0016300 "molecular_function:tRNA (uracil) methyltransferase activity" xref: GO:0016423 "molecular_function:tRNA (guanine) methyltransferase activity" xref: GO:0016426 "molecular_function:tRNA (adenine) methyltransferase activity" xref: GO:0016427 "molecular_function:tRNA (cytosine) methyltransferase activity" xref: GO:0016428 "molecular_function:tRNA (cytosine-5-)-methyltransferase activity" xref: GO:0016429 "molecular_function:tRNA (adenine-N1-)-methyltransferase activity" xref: GO:0016433 "molecular_function:rRNA (adenine) methyltransferase activity" xref: GO:0016434 "molecular_function:rRNA (cytosine) methyltransferase activity" xref: GO:0016435 "molecular_function:rRNA (guanine) methyltransferase activity" xref: GO:0016436 "molecular_function:rRNA (uridine) methyltransferase activity" xref: GO:0018423 "molecular_function:protein C-terminal leucine carboxyl O-methyltransferase activity" xref: GO:0018707 "molecular_function:1-phenanthrol methyltransferase activity" xref: GO:0019702 "molecular_function:protein-arginine N5-methyltransferase activity" xref: GO:0030792 "molecular_function:methylarsonite methyltransferase activity" xref: GO:0034541 "molecular_function:dimethylarsinite methyltransferase activity" xref: GO:0034807 "molecular_function:4,5-dihydroxybenzo(a)pyrene methyltransferase activity" xref: GO:0034931 "molecular_function:1-hydroxypyrene methyltransferase activity" xref: GO:0034933 "molecular_function:1-hydroxy-6-methoxypyrene methyltransferase activity" xref: GO:0043770 "molecular_function:demethylmenaquinone methyltransferase activity" xref: GO:0043776 "molecular_function:cobalt-precorrin-6B C5-methyltransferase activity" xref: GO:0043777 "molecular_function:cobalt-precorrin-7 C15-methyltransferase activity" xref: GO:0043780 "molecular_function:cobalt-precorrin-5B C1-methyltransferase activity" xref: GO:0043782 "molecular_function:cobalt-precorrin-3 C17-methyltransferase activity" xref: GO:0043791 "molecular_function:dimethylamine methyltransferase activity" xref: GO:0043803 "molecular_function:hydroxyneurosporene-O-methyltransferase activity" xref: GO:0043827 "molecular_function:tRNA (adenine-57, 58-N(1)-) methyltransferase activity" xref: GO:0043833 "molecular_function:methylamine-specific methylcobalamin:coenzyme M methyltransferase activity" xref: GO:0043834 "molecular_function:trimethylamine methyltransferase activity" xref: GO:0043851 "molecular_function:methanol-specific methylcobalamin:coenzyme M methyltransferase activity" xref: GO:0043852 "molecular_function:monomethylamine methyltransferase activity" xref: GO:0051994 "molecular_function:P-methyltransferase activity" xref: GO:0051995 "molecular_function:Se-methyltransferase activity" xref: GO:0052624 "molecular_function:2-phytyl-1,4-naphthoquinone methyltransferase activity" xref: GO:0052665 "molecular_function:tRNA (uracil-2'-O-)-methyltransferase activity" xref: GO:0052666 "molecular_function:tRNA (cytosine-2'-O-)-methyltransferase activity" xref: GO:0052667 "molecular_function:phosphomethylethanolamine N-methyltransferase activity" xref: GO:0052735 "molecular_function:tRNA (cytosine-3-)-methyltransferase activity" xref: GO:0070677 "molecular_function:rRNA (cytosine-2'-O-)-methyltransferase activity" xref: GO:0071424 "molecular_function:rRNA (cytosine-N4-)-methyltransferase activity" xref: GO:0080012 "molecular_function:trihydroxyferuloyl spermidine O-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11543 ! cobalt-precorrin-6B relationship: has_input_compound UPa:UPC11543 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin-6B relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11545 ! cobalt-precorrin 8 relationship: has_output_compound UPa:UPC11545 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 8 relationship: part_of UPa:ULS00092 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) relationship: part_of UPa:ULS00092 {cardinality="1", order="8"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00230 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 9/10 namespace: enzymatic_reaction def: "1 cobalt-precorrin 8 => 1 cob(III)yrinic acid." [] xref: EC:5.4.1 xref: GO:0016867 "molecular_function:intramolecular transferase activity, transferring acyl groups" xref: GO:0043778 "molecular_function:cobalt-precorrin-8 methylmutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC11545 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 8 relationship: has_input_compound UPa:UPC11545 ! cobalt-precorrin 8 relationship: has_output_compound UPa:UPC05773 ! cob(III)yrinic acid relationship: has_output_compound UPa:UPC05773 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(III)yrinic acid relationship: part_of UPa:ULS00092 {cardinality="1", order="9"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) relationship: part_of UPa:ULS00092 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00231 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10 namespace: enzymatic_reaction def: "2 ATP + 2 H(2)O + 2 L-glutamine + 1 cob(III)yrinic acid => 2 ADP + 2 L-glutamate + 1 cob(II)yrinate a,c-diamide + 2 phosphate." [] xref: EC:6.3.1 xref: GO:0016211 "molecular_function:ammonia ligase activity" xref: GO:0016880 "molecular_function:acid-ammonia (or amide) ligase activity" xref: GO:0043860 "molecular_function:cyanophycin synthetase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC05773 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(III)yrinic acid relationship: has_input_compound UPa:UPC05773 ! cob(III)yrinic acid relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC06504 ! cob(II)yrinate a,c-diamide relationship: has_output_compound UPa:UPC06504 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(II)yrinate a,c-diamide relationship: part_of UPa:ULS00092 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) relationship: part_of UPa:ULS00092 {cardinality="1", order="10"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00232 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 1/7 namespace: enzymatic_reaction def: "1 FMNH(2) + 2 cob(II)yrinate a,c-diamide => 1 FMN + 2 H(+) + 2 cob(I)yrinic acid a,c-diamide." [] xref: EC:1.16.8.1 xref: GO:0043784 "molecular_function:cob(II)yrinic acid a,c-diamide reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01847 ! FMNH(2) relationship: has_input_compound UPa:UPC01847 {cardinality="1", is_alternate="False", is_primary="False"} ! FMNH(2) relationship: has_input_compound UPa:UPC06504 ! cob(II)yrinate a,c-diamide relationship: has_input_compound UPa:UPC06504 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(II)yrinate a,c-diamide relationship: has_output_compound UPa:UPC00061 {cardinality="1", is_alternate="False", is_primary="False"} ! FMN relationship: has_output_compound UPa:UPC00061 ! FMN relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC06505 ! cob(I)yrinic acid a,c-diamide relationship: has_output_compound UPa:UPC06505 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(I)yrinic acid a,c-diamide relationship: part_of UPa:ULS00093 ! adenosylcobalamin from cob(II)yrinate a,c-diamide relationship: part_of UPa:ULS00093 {cardinality="1", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00233 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7 namespace: enzymatic_reaction def: "1 ATP + 1 cob(I)yrinic acid a,c-diamide => 1 adenosylcob(III)yrinic acid a,c-diamide + 1 triphosphate." [] xref: EC:2.5.1.17 xref: GO:0008817 "molecular_function:cob(I)yrinic acid a,c-diamide adenosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC06505 ! cob(I)yrinic acid a,c-diamide relationship: has_input_compound UPa:UPC06505 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(I)yrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00536 {cardinality="1", is_alternate="False", is_primary="False"} ! triphosphate relationship: has_output_compound UPa:UPC00536 ! triphosphate relationship: has_output_compound UPa:UPC06506 ! adenosylcob(III)yrinic acid a,c-diamide relationship: has_output_compound UPa:UPC06506 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcob(III)yrinic acid a,c-diamide relationship: part_of UPa:ULS00093 ! adenosylcobalamin from cob(II)yrinate a,c-diamide relationship: part_of UPa:ULS00093 {cardinality="1", order="2"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00234 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 3/7 namespace: enzymatic_reaction def: "4 ATP + 4 H(2)O + 4 L-glutamine + 1 adenosylcob(III)yrinic acid a,c-diamide => 4 ADP + 4 L-glutamate + 1 adenosylcobyrinic acid a,c-diamide + 4 phosphate." [] xref: EC:6.3.5.10 xref: GO:0051921 "molecular_function:adenosylcobyric acid synthase (glutamine-hydrolyzing) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC06506 ! adenosylcob(III)yrinic acid a,c-diamide relationship: has_input_compound UPa:UPC06506 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcob(III)yrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC06507 ! adenosylcobyrinic acid a,c-diamide relationship: has_output_compound UPa:UPC06507 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobyrinic acid a,c-diamide relationship: part_of UPa:ULS00093 {cardinality="1", order="3"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide relationship: part_of UPa:ULS00093 ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00235 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 4/7 namespace: enzymatic_reaction def: "1 (R)-1-aminopropan-2-ol + 1 adenosylcobyrinic acid a,c-diamide => 1 H(2)O + 1 adenosylcobinamide." [] xref: EC:6.3.1.10 xref: GO:0043757 "molecular_function:adenosylcobinamide-phosphate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03194 ! (R)-1-aminopropan-2-ol relationship: has_input_compound UPa:UPC03194 {cardinality="1", is_alternate="False", is_primary="False"} ! (R)-1-aminopropan-2-ol relationship: has_input_compound UPa:UPC06507 ! adenosylcobyrinic acid a,c-diamide relationship: has_input_compound UPa:UPC06507 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobyrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC06508 ! adenosylcobinamide relationship: has_output_compound UPa:UPC06508 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide relationship: part_of UPa:ULS00093 {cardinality="1", order="4"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide relationship: part_of UPa:ULS00093 ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00236 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7 namespace: enzymatic_reaction def: "adenosylcobinamide + [ATP or GTP] => adenosylcobinamide phosphate + [ADP or GDP]." [] xref: EC:2.7.1.156 xref: GO:0043752 "molecular_function:adenosylcobinamide kinase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00953 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00954 ! None relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="True", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00044 {cardinality="1", is_alternate="True", is_primary="False"} ! GTP relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC06508 ! adenosylcobinamide relationship: has_input_compound UPa:UPC06508 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="True", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00035 ! GDP relationship: has_output_compound UPa:UPC00035 {cardinality="1", is_alternate="True", is_primary="False"} ! GDP relationship: has_output_compound UPa:UPC06509 ! adenosylcobinamide phosphate relationship: has_output_compound UPa:UPC06509 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide phosphate relationship: part_of UPa:ULS00093 ! adenosylcobalamin from cob(II)yrinate a,c-diamide relationship: part_of UPa:ULS00093 {cardinality="1", order="5"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00237 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7 namespace: enzymatic_reaction def: "1 GTP + 1 adenosylcobinamide phosphate => 1 adenosylcobinamide-GDP + 1 diphosphate." [] xref: EC:2.7.7.62 xref: GO:0008820 "molecular_function:cobinamide phosphate guanylyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00044 {cardinality="1", is_alternate="False", is_primary="False"} ! GTP relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC06509 ! adenosylcobinamide phosphate relationship: has_input_compound UPa:UPC06509 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC06510 ! adenosylcobinamide-GDP relationship: has_output_compound UPa:UPC06510 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide-GDP relationship: part_of UPa:ULS00093 ! adenosylcobalamin from cob(II)yrinate a,c-diamide relationship: part_of UPa:ULS00093 {cardinality="1", order="6"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00238 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7 namespace: enzymatic_reaction def: "1 adenosylcobinamide-GDP + 1 alpha-ribazole => 1 GMP + 1 adenosylcobalamin." [] xref: EC:2.7.8.26 xref: GO:0051073 "molecular_function:adenosylcobinamide-GDP ribazoletransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC05775 ! alpha-ribazole relationship: has_input_compound UPa:UPC05775 {cardinality="1", is_alternate="False", is_primary="False"} ! alpha-ribazole relationship: has_input_compound UPa:UPC06510 ! adenosylcobinamide-GDP relationship: has_input_compound UPa:UPC06510 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide-GDP relationship: has_output_compound UPa:UPC00144 ! GMP relationship: has_output_compound UPa:UPC00144 {cardinality="1", is_alternate="False", is_primary="False"} ! GMP relationship: has_output_compound UPa:UPC00194 ! adenosylcobalamin relationship: has_output_compound UPa:UPC00194 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobalamin relationship: part_of UPa:ULS00093 {cardinality="1", order="7"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide relationship: part_of UPa:ULS00093 ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00239 name: penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 1/3 namespace: enzymatic_reaction def: "3 ATP + 1 H(2)O + 1 L-alpha-aminoadipate + 1 L-cysteine + 1 L-valine => 3 AMP + 1 N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 diphosphate." [] xref: EC:6.3.2.26 xref: GO:0050564 "molecular_function:N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cysteine relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC00183 ! L-valine relationship: has_input_compound UPa:UPC00183 {cardinality="1", is_alternate="False", is_primary="True"} ! L-valine relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC05556 ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine relationship: has_output_compound UPa:UPC05556 {cardinality="1", is_alternate="False", is_primary="True"} ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine relationship: part_of UPa:ULS00094 {cardinality="1", order="1"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine relationship: part_of UPa:ULS00094 ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine [Term] id: UPa:UER00240 name: penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 2/3 namespace: enzymatic_reaction def: "1 N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 1 O(2) => 2 H(2)O + 1 isopenicillin N." [] xref: EC:1.21.3.1 xref: GO:0016216 "molecular_function:isopenicillin-N synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC05556 {cardinality="1", is_alternate="False", is_primary="True"} ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine relationship: has_input_compound UPa:UPC05556 ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC05557 {cardinality="1", is_alternate="False", is_primary="True"} ! isopenicillin N relationship: has_output_compound UPa:UPC05557 ! isopenicillin N relationship: part_of UPa:ULS00094 {cardinality="1", order="2"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine relationship: part_of UPa:ULS00094 ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine [Term] id: UPa:UER00241 name: penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 isopenicillin N + 1 phenylacetyl-CoA => 1 CoA + 1 L-alpha-aminoadipate + 1 penicillin G." [] xref: EC:2.3.1.164 xref: GO:0050640 "molecular_function:isopenicillin-N N-acyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00582 ! phenylacetyl-CoA relationship: has_input_compound UPa:UPC00582 {cardinality="1", is_alternate="False", is_primary="False"} ! phenylacetyl-CoA relationship: has_input_compound UPa:UPC05557 {cardinality="1", is_alternate="False", is_primary="True"} ! isopenicillin N relationship: has_input_compound UPa:UPC05557 ! isopenicillin N relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="False"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC05551 {cardinality="1", is_alternate="False", is_primary="True"} ! penicillin G relationship: has_output_compound UPa:UPC05551 ! penicillin G relationship: part_of UPa:ULS00094 {cardinality="1", order="3"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine relationship: part_of UPa:ULS00094 ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine [Term] id: UPa:UER00242 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 1/8 namespace: enzymatic_reaction def: "1 D-glyceraldehyde 3-phosphate + 1 L-arginine => 1 N(2)-(2-carboxyethyl)-L-arginine + 1 phosphate." [] xref: EC:2.5.1.66 xref: GO:0033848 "molecular_function:N2-(2-carboxyethyl)arginine synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC06655 ! N(2)-(2-carboxyethyl)-L-arginine relationship: has_output_compound UPa:UPC06655 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-(2-carboxyethyl)-L-arginine relationship: part_of UPa:ULS00095 {cardinality="1", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine relationship: part_of UPa:ULS00095 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00243 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 2/8 namespace: enzymatic_reaction def: "1 ATP + 1 N(2)-(2-carboxyethyl)-L-arginine => 1 AMP + 1 deoxyamidinoproclavaminic acid + 1 diphosphate." [] xref: EC:6.3.3.4 xref: GO:0034027 "molecular_function:(carboxyethyl)arginine beta-lactam-synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC06655 ! N(2)-(2-carboxyethyl)-L-arginine relationship: has_input_compound UPa:UPC06655 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-(2-carboxyethyl)-L-arginine relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC06656 ! deoxyamidinoproclavaminic acid relationship: has_output_compound UPa:UPC06656 {cardinality="1", is_alternate="False", is_primary="True"} ! deoxyamidinoproclavaminic acid relationship: part_of UPa:ULS00095 {cardinality="1", order="2"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine relationship: part_of UPa:ULS00095 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00244 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 3/8 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 O(2) + 1 deoxyamidinoproclavaminic acid => 1 CO(2) + 1 amidinoproclavaminic acid + 1 succinate." [] xref: EC:1.14.11.21 xref: GO:0033758 "molecular_function:clavaminate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06656 ! deoxyamidinoproclavaminic acid relationship: has_input_compound UPa:UPC06656 {cardinality="1", is_alternate="False", is_primary="True"} ! deoxyamidinoproclavaminic acid relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC06657 ! amidinoproclavaminic acid relationship: has_output_compound UPa:UPC06657 {cardinality="1", is_alternate="False", is_primary="True"} ! amidinoproclavaminic acid relationship: part_of UPa:ULS00095 {cardinality="1", order="3"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine relationship: part_of UPa:ULS00095 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00245 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 4/8 namespace: enzymatic_reaction def: "1 H(2)O + 1 amidinoproclavaminic acid => 1 proclavaminic acid + 1 urea." [] xref: EC:3.5.3.22 xref: GO:0033972 "molecular_function:proclavaminate amidinohydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC06657 ! amidinoproclavaminic acid relationship: has_input_compound UPa:UPC06657 {cardinality="1", is_alternate="False", is_primary="True"} ! amidinoproclavaminic acid relationship: has_output_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00086 {cardinality="1", is_alternate="False", is_primary="False"} ! urea relationship: has_output_compound UPa:UPC06658 ! proclavaminic acid relationship: has_output_compound UPa:UPC06658 {cardinality="1", is_alternate="False", is_primary="True"} ! proclavaminic acid relationship: part_of UPa:ULS00095 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine relationship: part_of UPa:ULS00095 {cardinality="1", order="4"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00246 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 5/8 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 O(2) + 1 proclavaminic acid => 1 CO(2) + 1 H(2)O + 1 dihydroclavaminic acid + 1 succinate." [] xref: EC:1.14.11.21 xref: GO:0033758 "molecular_function:clavaminate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06658 ! proclavaminic acid relationship: has_input_compound UPa:UPC06658 {cardinality="1", is_alternate="False", is_primary="True"} ! proclavaminic acid relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC06659 ! dihydroclavaminic acid relationship: has_output_compound UPa:UPC06659 {cardinality="1", is_alternate="False", is_primary="True"} ! dihydroclavaminic acid relationship: part_of UPa:ULS00095 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine relationship: part_of UPa:ULS00095 {cardinality="1", order="5"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00247 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 6/8 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 O(2) + 1 dihydroclavaminic acid => 1 CO(2) + 1 H(2)O + 1 clavaminate + 1 succinate." [] xref: EC:1.14.11.21 xref: GO:0033758 "molecular_function:clavaminate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06659 ! dihydroclavaminic acid relationship: has_input_compound UPa:UPC06659 {cardinality="1", is_alternate="False", is_primary="True"} ! dihydroclavaminic acid relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC06660 ! clavaminate relationship: has_output_compound UPa:UPC06660 {cardinality="1", is_alternate="False", is_primary="True"} ! clavaminate relationship: part_of UPa:ULS00095 {cardinality="1", order="6"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine relationship: part_of UPa:ULS00095 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00248 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 7/8 namespace: enzymatic_reaction def: "1 clavaminate => 1 clavulanate-9-aldehyde." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC06660 ! clavaminate relationship: has_input_compound UPa:UPC06660 {cardinality="1", is_alternate="False", is_primary="True"} ! clavaminate relationship: has_output_compound UPa:UPC06661 ! clavulanate-9-aldehyde relationship: has_output_compound UPa:UPC06661 {cardinality="1", is_alternate="False", is_primary="True"} ! clavulanate-9-aldehyde relationship: part_of UPa:ULS00095 {cardinality="1", order="7"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine relationship: part_of UPa:ULS00095 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00249 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 8/8 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 clavulanate-9-aldehyde => 1 NADP(+) + 1 clavulanate." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC06661 ! clavulanate-9-aldehyde relationship: has_input_compound UPa:UPC06661 {cardinality="1", is_alternate="False", is_primary="True"} ! clavulanate-9-aldehyde relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC06662 ! clavulanate relationship: has_output_compound UPa:UPC06662 {cardinality="1", is_alternate="False", is_primary="True"} ! clavulanate relationship: part_of UPa:ULS00095 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine relationship: part_of UPa:ULS00095 {cardinality="1", order="8"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00250 name: 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 1/4 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 biphenyl => 1 NAD(+) + 1 cis-3-phenylcyclohexa-3,5-diene-1,2-diol." [] xref: EC:1.14.12.18 xref: GO:0018687 "molecular_function:biphenyl 2,3-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC06588 ! biphenyl relationship: has_input_compound UPa:UPC06588 {cardinality="1", is_alternate="False", is_primary="True"} ! biphenyl relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC06589 ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol relationship: has_output_compound UPa:UPC06589 {cardinality="1", is_alternate="False", is_primary="True"} ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol relationship: part_of UPa:ULS00096 ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl relationship: part_of UPa:ULS00096 {cardinality="1", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl [Term] id: UPa:UER00251 name: 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 2/4 namespace: enzymatic_reaction def: "1 NAD(+) + 1 cis-3-phenylcyclohexa-3,5-diene-1,2-diol => 1 H(+) + 1 NADH + 1 biphenyl-2,3-diol." [] xref: EC:1.3.1.56 xref: GO:0018509 "molecular_function:cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC06589 ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol relationship: has_input_compound UPa:UPC06589 {cardinality="1", is_alternate="False", is_primary="True"} ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC02526 {cardinality="1", is_alternate="False", is_primary="True"} ! biphenyl-2,3-diol relationship: has_output_compound UPa:UPC02526 ! biphenyl-2,3-diol relationship: part_of UPa:ULS00096 ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl relationship: part_of UPa:ULS00096 {cardinality="1", order="2"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl [Term] id: UPa:UER00252 name: 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 3/4 namespace: enzymatic_reaction def: "1 O(2) + 1 biphenyl-2,3-diol => 1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate." [] xref: EC:1.13.11.39 xref: GO:0018583 "molecular_function:biphenyl-2,3-diol 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC02526 ! biphenyl-2,3-diol relationship: has_input_compound UPa:UPC02526 {cardinality="1", is_alternate="False", is_primary="True"} ! biphenyl-2,3-diol relationship: has_output_compound UPa:UPC01273 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate relationship: has_output_compound UPa:UPC01273 ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate relationship: part_of UPa:ULS00096 ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl relationship: part_of UPa:ULS00096 {cardinality="1", order="3"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl [Term] id: UPa:UER00253 name: 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 4/4 namespace: enzymatic_reaction def: "1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + 1 H(2)O => 1 2-hydroxy-2,4-pentadienoate + 1 benzoate." [] xref: EC:3.7.1.8 xref: GO:0018774 "molecular_function:2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01273 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate relationship: has_input_compound UPa:UPC01273 ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate relationship: has_output_compound UPa:UPC00180 ! benzoate relationship: has_output_compound UPa:UPC00180 {cardinality="1", is_alternate="False", is_primary="True"} ! benzoate relationship: has_output_compound UPa:UPC00596 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: part_of UPa:ULS00096 ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl relationship: part_of UPa:ULS00096 {cardinality="1", order="4"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl [Term] id: UPa:UER00254 name: catechol from benzoate: step 1/2 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 benzoate => 1 (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid + 1 NAD(+)." [] xref: EC:1.14.12.10 xref: GO:0018623 "molecular_function:benzoate 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00180 {cardinality="1", is_alternate="False", is_primary="True"} ! benzoate relationship: has_input_compound UPa:UPC00180 ! benzoate relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC06321 ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid relationship: has_output_compound UPa:UPC06321 {cardinality="1", is_alternate="False", is_primary="True"} ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid relationship: part_of UPa:ULS00097 ! catechol from benzoate relationship: part_of UPa:ULS00097 {cardinality="1", order="1"} ! catechol from benzoate [Term] id: UPa:UER00255 name: catechol from benzoate: step 2/2 namespace: enzymatic_reaction def: "1 (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid + 1 NAD(+) => 1 CO(2) + 1 H(+) + 1 NADH + 1 catechol." [] xref: EC:1.3.1.25 xref: GO:0047116 "molecular_function:1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC06321 ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid relationship: has_input_compound UPa:UPC06321 {cardinality="1", is_alternate="False", is_primary="True"} ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00090 {cardinality="1", is_alternate="False", is_primary="True"} ! catechol relationship: has_output_compound UPa:UPC00090 ! catechol relationship: part_of UPa:ULS00097 ! catechol from benzoate relationship: part_of UPa:ULS00097 {cardinality="1", order="2"} ! catechol from benzoate [Term] id: UPa:UER00256 name: 3,4-dihydroxybenzoate from benzoate: step 1/2 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 O(2) + 1 benzoate => 1 4-hydroxybenzoate + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.12 xref: GO:0018664 "molecular_function:benzoate 4-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00180 {cardinality="1", is_alternate="False", is_primary="True"} ! benzoate relationship: has_input_compound UPa:UPC00180 ! benzoate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00156 ! 4-hydroxybenzoate relationship: has_output_compound UPa:UPC00156 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-hydroxybenzoate relationship: part_of UPa:ULS00098 {cardinality="1", order="1"} ! 3,4-dihydroxybenzoate from benzoate relationship: part_of UPa:ULS00098 ! 3,4-dihydroxybenzoate from benzoate [Term] id: UPa:UER00257 name: 3,4-dihydroxybenzoate from benzoate: step 2/2 namespace: enzymatic_reaction def: "1 4-hydroxybenzoate + 1 H(+) + 1 NADPH + 1 O(2) => 1 3,4-dihydroxybenzoate + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.2 xref: GO:0018659 "molecular_function:4-hydroxybenzoate 3-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00156 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-hydroxybenzoate relationship: has_input_compound UPa:UPC00156 ! 4-hydroxybenzoate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00230 {cardinality="1", is_alternate="False", is_primary="True"} ! 3,4-dihydroxybenzoate relationship: part_of UPa:ULS00098 {cardinality="1", order="2"} ! 3,4-dihydroxybenzoate from benzoate relationship: part_of UPa:ULS00098 ! 3,4-dihydroxybenzoate from benzoate [Term] id: UPa:UER00258 name: 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 1/3 namespace: enzymatic_reaction def: "1 O(2) + 1 catechol => 1 cis,cis-muconate." [] xref: EC:1.13.11.1 xref: GO:0018576 "molecular_function:catechol 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00090 {cardinality="1", is_alternate="False", is_primary="True"} ! catechol relationship: has_input_compound UPa:UPC00090 ! catechol relationship: has_output_compound UPa:UPC02480 {cardinality="1", is_alternate="False", is_primary="True"} ! cis,cis-muconate relationship: has_output_compound UPa:UPC02480 ! cis,cis-muconate relationship: part_of UPa:ULS00099 ! 5-oxo-4,5-dihydro-2-furylacetate from catechol relationship: part_of UPa:ULS00099 {cardinality="1", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol [Term] id: UPa:UER00259 name: 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 2/3 namespace: enzymatic_reaction def: "1 cis,cis-muconate => 1 (S)-5-oxo-2,5-dihydro-2-furylacetic acid." [] xref: EC:5.5.1.1 xref: GO:0018849 "molecular_function:muconate cycloisomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC02480 {cardinality="1", is_alternate="False", is_primary="True"} ! cis,cis-muconate relationship: has_input_compound UPa:UPC02480 ! cis,cis-muconate relationship: has_output_compound UPa:UPC14610 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid relationship: has_output_compound UPa:UPC14610 ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid relationship: part_of UPa:ULS00099 ! 5-oxo-4,5-dihydro-2-furylacetate from catechol relationship: part_of UPa:ULS00099 {cardinality="1", order="2"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol [Term] id: UPa:UER00260 name: 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 3/3 namespace: enzymatic_reaction def: "1 (S)-5-oxo-2,5-dihydro-2-furylacetic acid => 1 5-oxo-4,5-dihydro-2-furylacetate." [] xref: EC:5.3.3.4 xref: GO:0016159 "molecular_function:muconolactone delta-isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC14610 ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid relationship: has_input_compound UPa:UPC14610 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid relationship: has_output_compound UPa:UPC03586 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_output_compound UPa:UPC03586 ! 5-oxo-4,5-dihydro-2-furylacetate relationship: part_of UPa:ULS00099 {cardinality="1", order="3"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol relationship: part_of UPa:ULS00099 ! 5-oxo-4,5-dihydro-2-furylacetate from catechol [Term] id: UPa:UER00261 name: 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate: step 1/1 namespace: enzymatic_reaction def: "1 5-oxo-4,5-dihydro-2-furylacetate + 1 H(2)O => 1 3-oxoadipate." [] xref: EC:3.1.1.24 xref: GO:0047570 "molecular_function:3-oxoadipate enol-lactonase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC03586 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_input_compound UPa:UPC03586 ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_output_compound UPa:UPC00846 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxoadipate relationship: has_output_compound UPa:UPC00846 ! 3-oxoadipate relationship: part_of UPa:ULS00100 ! 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate relationship: part_of UPa:ULS00100 {cardinality="1", order="1"} ! 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate [Term] id: UPa:UER00262 name: acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 1/2 namespace: enzymatic_reaction def: "1 3-oxoadipate + 1 succinyl-CoA => 1 3-oxoadipyl-CoA + 1 succinate." [] xref: EC:2.8.3.6 xref: GO:0047569 "molecular_function:3-oxoadipate CoA-transferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="False"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00846 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxoadipate relationship: has_input_compound UPa:UPC00846 ! 3-oxoadipate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC02232 ! 3-oxoadipyl-CoA relationship: has_output_compound UPa:UPC02232 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxoadipyl-CoA relationship: part_of UPa:ULS00101 ! acetyl-CoA and succinyl-CoA from 3-oxoadipate relationship: part_of UPa:ULS00101 {cardinality="1", order="1"} ! acetyl-CoA and succinyl-CoA from 3-oxoadipate [Term] id: UPa:UER00263 name: acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 2/2 namespace: enzymatic_reaction def: "1 3-oxoadipyl-CoA + 1 CoA => 1 acetyl-CoA + 1 succinyl-CoA." [] xref: EC:2.3.1.174 xref: GO:0033812 "molecular_function:3-oxoadipyl-CoA thiolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC02232 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxoadipyl-CoA relationship: has_input_compound UPa:UPC02232 ! 3-oxoadipyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="True"} ! succinyl-CoA relationship: part_of UPa:ULS00101 ! acetyl-CoA and succinyl-CoA from 3-oxoadipate relationship: part_of UPa:ULS00101 {cardinality="1", order="2"} ! acetyl-CoA and succinyl-CoA from 3-oxoadipate [Term] id: UPa:UER00264 name: 3-carboxy-cis,cis-muconate from 3,4-dihydroxybenzoate: step 1/1 namespace: enzymatic_reaction def: "1 3,4-dihydroxybenzoate + 1 O(2) => 1 3-carboxy-cis,cis-muconate." [] xref: EC:1.13.11.3 xref: GO:0018578 "molecular_function:protocatechuate 3,4-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_input_compound UPa:UPC00230 {cardinality="1", is_alternate="False", is_primary="True"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC01163 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-carboxy-cis,cis-muconate relationship: has_output_compound UPa:UPC01163 ! 3-carboxy-cis,cis-muconate relationship: part_of UPa:ULS00102 ! 3-carboxy-cis,cis-muconate from 3,4-dihydroxybenzoate relationship: part_of UPa:ULS00102 {cardinality="1", order="1"} ! 3-carboxy-cis,cis-muconate from 3,4-dihydroxybenzoate [Term] id: UPa:UER00265 name: 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 1/2 namespace: enzymatic_reaction def: "1 3-carboxy-cis,cis-muconate => 1 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate." [] xref: EC:5.5.1.2 xref: GO:0047472 "molecular_function:3-carboxy-cis,cis-muconate cycloisomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01163 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-carboxy-cis,cis-muconate relationship: has_input_compound UPa:UPC01163 ! 3-carboxy-cis,cis-muconate relationship: has_output_compound UPa:UPC01278 ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_output_compound UPa:UPC01278 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: part_of UPa:ULS00130 ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate relationship: part_of UPa:ULS00130 {cardinality="1", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate [Term] id: UPa:UER00266 name: 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 2/2 namespace: enzymatic_reaction def: "1 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate => 1 5-oxo-4,5-dihydro-2-furylacetate + 1 CO(2)." [] xref: EC:4.1.1.44 xref: GO:0047575 "molecular_function:4-carboxymuconolactone decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01278 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_input_compound UPa:UPC01278 ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC03586 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_output_compound UPa:UPC03586 ! 5-oxo-4,5-dihydro-2-furylacetate relationship: part_of UPa:ULS00130 ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate relationship: part_of UPa:ULS00130 {cardinality="1", order="2"} ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate [Term] id: UPa:UER00267 name: 3-oxoadipate from 3,4-dihydroxybenzoate: step 1/4 namespace: enzymatic_reaction def: "3,4-dihydroxybenzoate + H(+) + O(2) + [NADH or NADPH] => CO(2) + H(2)O + benzene-1,2,4-triol + [NAD(+) or NADP(+)]." [] xref: EC:1.13.11 xref: GO:0016702 "molecular_function:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" xref: GO:0018542 "molecular_function:2,3-dihydroxy DDT 1,2-dioxygenase activity" xref: GO:0018555 "molecular_function:phenanthrene dioxygenase activity" xref: GO:0018556 "molecular_function:2,2',3-trihydroxybiphenyl dioxygenase activity" xref: GO:0018557 "molecular_function:1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity" xref: GO:0018558 "molecular_function:5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity" xref: GO:0018559 "molecular_function:1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity" xref: GO:0018560 "molecular_function:protocatechuate 3,4-dioxygenase type II activity" xref: GO:0018561 "molecular_function:2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity" xref: GO:0018562 "molecular_function:3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity" xref: GO:0018563 "molecular_function:2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity" xref: GO:0018564 "molecular_function:carbazole 1,9a-dioxygenase activity" xref: GO:0018565 "molecular_function:dihydroxydibenzothiophene dioxygenase activity" xref: GO:0018566 "molecular_function:1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity" xref: GO:0018567 "molecular_function:styrene dioxygenase activity" xref: GO:0018568 "molecular_function:3,4-dihydroxyphenanthrene dioxygenase activity" xref: GO:0018569 "molecular_function:hydroquinone 1,2-dioxygenase activity" xref: GO:0018570 "molecular_function:p-cumate 2,3-dioxygenase activity" xref: GO:0018571 "molecular_function:2,3-dihydroxy-p-cumate dioxygenase activity" xref: GO:0018572 "molecular_function:3,5-dichlorocatechol 1,2-dioxygenase activity" xref: GO:0018573 "molecular_function:2-aminophenol 1,6-dioxygenase activity" xref: GO:0018574 "molecular_function:2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity" xref: GO:0018575 "molecular_function:chlorocatechol 1,2-dioxygenase activity" xref: GO:0019114 "molecular_function:catechol dioxygenase activity" xref: GO:0019117 "molecular_function:dihydroxyfluorene dioxygenase activity" xref: GO:0034543 "molecular_function:5-aminosalicylate dioxygenase activity" xref: GO:0034803 "molecular_function:3-hydroxy-2-naphthoate 2,3-dioxygenase activity" xref: GO:0034806 "molecular_function:benzo(a)pyrene 11,12-dioxygenase activity" xref: GO:0034808 "molecular_function:benzo(a)pyrene 4,5-dioxygenase activity" xref: GO:0034810 "molecular_function:4,5-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034811 "molecular_function:benzo(a)pyrene 9,10-dioxygenase activity" xref: GO:0034812 "molecular_function:9,10-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034813 "molecular_function:benzo(a)pyrene 7,8-dioxygenase activity" xref: GO:0034814 "molecular_function:7,8-dihydroxy benzo(a)pyrene dioxygenase activity" xref: GO:0034827 "molecular_function:1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity" xref: GO:0034834 "molecular_function:2-mercaptobenzothiazole dioxygenase activity" xref: GO:0034895 "molecular_function:pyridine-3,4-diol dioxygenase activity" xref: GO:0034920 "molecular_function:pyrene dioxygenase activity" xref: GO:0034922 "molecular_function:4,5-dihydroxypyrene dioxygenase activity" xref: GO:0034934 "molecular_function:phenanthrene-4-carboxylate dioxygenase activity" xref: GO:0034935 "molecular_function:tetrachlorobenzene dioxygenase activity" xref: GO:0034936 "molecular_function:4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity" xref: GO:0034955 "molecular_function:2,3-dihydroxydiphenyl ether dioxygenase activity" xref: GO:0034956 "molecular_function:diphenyl ether 1,2-dioxygenase activity" xref: GO:0036403 "molecular_function:arachidonate 8(S)-lipoxygenase activity" xref: GO:0047074 "molecular_function:4-hydroxycatechol 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00955 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00956 ! None relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_input_compound UPa:UPC00230 {cardinality="1", is_alternate="False", is_primary="True"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC02814 {cardinality="1", is_alternate="False", is_primary="True"} ! benzene-1,2,4-triol relationship: has_output_compound UPa:UPC02814 ! benzene-1,2,4-triol relationship: part_of UPa:ULS00103 ! 3-oxoadipate from 3,4-dihydroxybenzoate relationship: part_of UPa:ULS00103 {cardinality="1", order="1"} ! 3-oxoadipate from 3,4-dihydroxybenzoate [Term] id: UPa:UER00268 name: 3-oxoadipate from 3,4-dihydroxybenzoate: step 2/4 namespace: enzymatic_reaction def: "1 O(2) + 1 benzene-1,2,4-triol => 1 3-hydroxy-cis,cis-muconate." [] xref: EC:1.13.11.37 xref: GO:0018581 "molecular_function:hydroxyquinol 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC02814 ! benzene-1,2,4-triol relationship: has_input_compound UPa:UPC02814 {cardinality="1", is_alternate="False", is_primary="True"} ! benzene-1,2,4-triol relationship: has_output_compound UPa:UPC03676 ! 3-hydroxy-cis,cis-muconate relationship: has_output_compound UPa:UPC03676 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxy-cis,cis-muconate relationship: part_of UPa:ULS00103 ! 3-oxoadipate from 3,4-dihydroxybenzoate relationship: part_of UPa:ULS00103 {cardinality="1", order="2"} ! 3-oxoadipate from 3,4-dihydroxybenzoate [Term] id: UPa:UER00269 name: 3-oxoadipate from 3,4-dihydroxybenzoate: step 3/4 namespace: enzymatic_reaction def: "1 3-hydroxy-cis,cis-muconate => 1 maleylacetate." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03676 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxy-cis,cis-muconate relationship: has_input_compound UPa:UPC03676 ! 3-hydroxy-cis,cis-muconate relationship: has_output_compound UPa:UPC02222 ! maleylacetate relationship: has_output_compound UPa:UPC02222 {cardinality="1", is_alternate="False", is_primary="True"} ! maleylacetate relationship: part_of UPa:ULS00103 ! 3-oxoadipate from 3,4-dihydroxybenzoate relationship: part_of UPa:ULS00103 {cardinality="1", order="3"} ! 3-oxoadipate from 3,4-dihydroxybenzoate [Term] id: UPa:UER00270 name: L-ornithine and urea from L-arginine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-arginine => 1 L-ornithine + 1 urea." [] xref: EC:3.5.3.1 xref: GO:0004053 "molecular_function:arginase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_output_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_output_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00086 {cardinality="1", is_alternate="False", is_primary="True"} ! urea relationship: part_of UPa:ULS00177 {cardinality="1", order="1"} ! L-ornithine and urea from L-arginine relationship: part_of UPa:ULS00177 ! L-ornithine and urea from L-arginine [Term] id: UPa:UER00271 name: L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1 namespace: enzymatic_reaction def: "1 L-ornithine + 1 carbamoyl phosphate => 1 L-citrulline + 1 phosphate." [] xref: EC:2.1.3.3 xref: GO:0004585 "molecular_function:ornithine carbamoyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_input_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_input_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="True"} ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00327 {cardinality="1", is_alternate="False", is_primary="True"} ! L-citrulline relationship: has_output_compound UPa:UPC00327 ! L-citrulline relationship: part_of UPa:ULS00178 {cardinality="1", order="1"} ! L-citrulline from L-ornithine and carbamoyl phosphate relationship: part_of UPa:ULS00178 ! L-citrulline from L-ornithine and carbamoyl phosphate [Term] id: UPa:UER00272 name: (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 L-aspartate + 1 L-citrulline => 1 (N(omega)-L-arginino)succinate + 1 AMP + 1 diphosphate." [] xref: EC:6.3.4.5 xref: GO:0004055 "molecular_function:argininosuccinate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_input_compound UPa:UPC00327 {cardinality="1", is_alternate="False", is_primary="True"} ! L-citrulline relationship: has_input_compound UPa:UPC00327 ! L-citrulline relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC03406 ! (N(omega)-L-arginino)succinate relationship: has_output_compound UPa:UPC03406 {cardinality="1", is_alternate="False", is_primary="True"} ! (N(omega)-L-arginino)succinate relationship: part_of UPa:ULS00179 {cardinality="1", order="1"} ! (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline relationship: part_of UPa:ULS00179 ! (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline [Term] id: UPa:UER00273 name: L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1 namespace: enzymatic_reaction def: "1 (N(omega)-L-arginino)succinate => 1 L-arginine + 1 fumarate." [] xref: EC:4.3.2.1 xref: GO:0004056 "molecular_function:argininosuccinate lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03406 ! (N(omega)-L-arginino)succinate relationship: has_input_compound UPa:UPC03406 {cardinality="1", is_alternate="False", is_primary="True"} ! (N(omega)-L-arginino)succinate relationship: has_output_compound UPa:UPC00062 ! L-arginine relationship: has_output_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_output_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="True"} ! fumarate relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: part_of UPa:ULS00180 {cardinality="1", order="1"} ! L-arginine and fumarate from (N(omega)-L-arginino)succinate relationship: part_of UPa:ULS00180 ! L-arginine and fumarate from (N(omega)-L-arginino)succinate [Term] id: UPa:UER00274 name: UDP from UMP (UMK/CMK route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 UMP => 1 ADP + 1 UDP." [] xref: EC:2.7.4.14 xref: GO:0004127 "molecular_function:cytidylate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00105 ! UMP relationship: has_input_compound UPa:UPC00105 {cardinality="1", is_alternate="False", is_primary="True"} ! UMP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00015 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP relationship: part_of UPa:ULS00105 {cardinality="1", order="1"} ! UDP from UMP (UMK/CMK route) relationship: part_of UPa:ULS00105 ! UDP from UMP (UMK/CMK route) [Term] id: UPa:UER00275 name: UDP from UMP (UMPK route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 UMP => 1 ADP + 1 UDP." [] xref: EC:2.7.4.22 xref: GO:0033862 "molecular_function:UMP kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00105 ! UMP relationship: has_input_compound UPa:UPC00105 {cardinality="1", is_alternate="False", is_primary="True"} ! UMP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00015 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP relationship: part_of UPa:ULS00106 {cardinality="1", order="1"} ! UDP from UMP (UMPK route) relationship: part_of UPa:ULS00106 ! UDP from UMP (UMPK route) [Term] id: UPa:UER00276 name: CTP from UDP: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 UDP => 1 ADP + 1 UTP." [] xref: EC:2.7.4.6 xref: GO:0004550 "molecular_function:nucleoside diphosphate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00015 ! UDP relationship: has_input_compound UPa:UPC00015 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00075 {cardinality="1", is_alternate="False", is_primary="True"} ! UTP relationship: has_output_compound UPa:UPC00075 ! UTP relationship: part_of UPa:ULS00107 {cardinality="1", order="1"} ! CTP from UDP relationship: part_of UPa:ULS00107 ! CTP from UDP [Term] id: UPa:UER00277 name: CTP from UDP: step 2/2 namespace: enzymatic_reaction def: "1 ATP + 1 NH(3) + 1 UTP => 1 ADP + 1 CTP + 1 phosphate." [] xref: EC:6.3.4.2 xref: GO:0003883 "molecular_function:CTP synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00075 ! UTP relationship: has_input_compound UPa:UPC00075 {cardinality="1", is_alternate="False", is_primary="True"} ! UTP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00063 {cardinality="1", is_alternate="False", is_primary="True"} ! CTP relationship: has_output_compound UPa:UPC00063 ! CTP relationship: part_of UPa:ULS00107 {cardinality="1", order="2"} ! CTP from UDP relationship: part_of UPa:ULS00107 ! CTP from UDP [Term] id: UPa:UER00278 name: 3-oxoadipate from 3,4-dihydroxybenzoate: step 4/4 namespace: enzymatic_reaction def: "H(+) + maleylacetate + [NADH or NADPH] => 3-oxoadipate + [NAD(+) or NADP(+)]." [] xref: EC:1.3.1.32 xref: GO:0018506 "molecular_function:maleylacetate reductase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00957 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00958 ! None relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC02222 {cardinality="1", is_alternate="False", is_primary="True"} ! maleylacetate relationship: has_input_compound UPa:UPC02222 ! maleylacetate relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00846 ! 3-oxoadipate relationship: has_output_compound UPa:UPC00846 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxoadipate relationship: part_of UPa:ULS00103 {cardinality="1", order="4"} ! 3-oxoadipate from 3,4-dihydroxybenzoate relationship: part_of UPa:ULS00103 ! 3-oxoadipate from 3,4-dihydroxybenzoate [Term] id: UPa:UER00279 name: L-glutamate and succinate from L-arginine: step 1/5 namespace: enzymatic_reaction def: "1 L-arginine + 1 succinyl-CoA => 1 CoA + 1 N(2)-succinyl-L-arginine." [] xref: EC:2.3.1.109 xref: GO:0008791 "molecular_function:arginine N-succinyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="False"} ! succinyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC03296 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-succinyl-L-arginine relationship: has_output_compound UPa:UPC03296 ! N(2)-succinyl-L-arginine relationship: part_of UPa:ULS00109 {cardinality="1", order="1"} ! L-glutamate and succinate from L-arginine relationship: part_of UPa:ULS00109 ! L-glutamate and succinate from L-arginine [Term] id: UPa:UER00280 name: L-glutamate and succinate from L-arginine: step 2/5 namespace: enzymatic_reaction def: "2 H(2)O + 1 N(2)-succinyl-L-arginine => 1 CO(2) + 1 N(2)-succinyl-L-ornithine + 2 NH(3)." [] xref: EC:3.5.3.23 xref: GO:0009015 "molecular_function:N-succinylarginine dihydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC03296 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-succinyl-L-arginine relationship: has_input_compound UPa:UPC03296 ! N(2)-succinyl-L-arginine relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC03415 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-succinyl-L-ornithine relationship: has_output_compound UPa:UPC03415 ! N(2)-succinyl-L-ornithine relationship: part_of UPa:ULS00109 ! L-glutamate and succinate from L-arginine relationship: part_of UPa:ULS00109 {cardinality="1", order="2"} ! L-glutamate and succinate from L-arginine [Term] id: UPa:UER00281 name: L-glutamate and succinate from L-arginine: step 3/5 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 N(2)-succinyl-L-ornithine => 1 L-glutamate + 1 N-succinyl-L-glutamate 5-semialdehyde." [] xref: EC:2.6.1.81 xref: GO:0043825 "molecular_function:succinylornithine transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC03415 ! N(2)-succinyl-L-ornithine relationship: has_input_compound UPa:UPC03415 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-succinyl-L-ornithine relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC05932 ! N-succinyl-L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC05932 {cardinality="1", is_alternate="False", is_primary="True"} ! N-succinyl-L-glutamate 5-semialdehyde relationship: part_of UPa:ULS00109 ! L-glutamate and succinate from L-arginine relationship: part_of UPa:ULS00109 {cardinality="1", order="3"} ! L-glutamate and succinate from L-arginine [Term] id: UPa:UER00282 name: L-glutamate and succinate from L-arginine: step 4/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-succinyl-L-glutamate 5-semialdehyde + 1 NAD(+) => 1 H(+) + 1 N(2)-succinyl-L-glutamic acid + 1 NADH." [] xref: EC:1.2.1.71 xref: GO:0043824 "molecular_function:succinylglutamate-semialdehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC05932 ! N-succinyl-L-glutamate 5-semialdehyde relationship: has_input_compound UPa:UPC05932 {cardinality="1", is_alternate="False", is_primary="True"} ! N-succinyl-L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC05931 ! N(2)-succinyl-L-glutamic acid relationship: has_output_compound UPa:UPC05931 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-succinyl-L-glutamic acid relationship: part_of UPa:ULS00109 ! L-glutamate and succinate from L-arginine relationship: part_of UPa:ULS00109 {cardinality="1", order="4"} ! L-glutamate and succinate from L-arginine [Term] id: UPa:UER00283 name: L-glutamate and succinate from L-arginine: step 5/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 N(2)-succinyl-L-glutamic acid => 1 L-glutamate + 1 succinate." [] xref: EC:3.5.1.96 xref: GO:0009017 "molecular_function:succinylglutamate desuccinylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC05931 ! N(2)-succinyl-L-glutamic acid relationship: has_input_compound UPa:UPC05931 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-succinyl-L-glutamic acid relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: part_of UPa:ULS00109 ! L-glutamate and succinate from L-arginine relationship: part_of UPa:ULS00109 {cardinality="1", order="5"} ! L-glutamate and succinate from L-arginine [Term] id: UPa:UER00284 name: agmatine from L-arginine: step 1/1 namespace: enzymatic_reaction def: "1 L-arginine => 1 CO(2) + 1 agmatine." [] xref: EC:4.1.1.19 xref: GO:0008792 "molecular_function:arginine decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00179 ! agmatine relationship: has_output_compound UPa:UPC00179 {cardinality="1", is_alternate="False", is_primary="True"} ! agmatine relationship: part_of UPa:ULS00110 ! agmatine from L-arginine relationship: part_of UPa:ULS00110 {cardinality="1", order="1"} ! agmatine from L-arginine [Term] id: UPa:UER00285 name: N-carbamoylputrescine from agmatine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 agmatine => 1 N-carbamoylputrescine + 1 NH(3)." [] xref: EC:3.5.3.12 xref: GO:0047632 "molecular_function:agmatine deiminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00179 ! agmatine relationship: has_input_compound UPa:UPC00179 {cardinality="1", is_alternate="False", is_primary="True"} ! agmatine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00436 {cardinality="1", is_alternate="False", is_primary="True"} ! N-carbamoylputrescine relationship: has_output_compound UPa:UPC00436 ! N-carbamoylputrescine relationship: part_of UPa:ULS00111 ! N-carbamoylputrescine from agmatine relationship: part_of UPa:ULS00111 {cardinality="1", order="1"} ! N-carbamoylputrescine from agmatine [Term] id: UPa:UER00286 name: putrescine from N-carbamoylputrescine (amidase route): step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-carbamoylputrescine => 1 CO(2) + 1 NH(3) + 1 putrescine." [] xref: EC:3.5.1.53 xref: GO:0050126 "molecular_function:N-carbamoylputrescine amidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00436 ! N-carbamoylputrescine relationship: has_input_compound UPa:UPC00436 {cardinality="1", is_alternate="False", is_primary="True"} ! N-carbamoylputrescine relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: part_of UPa:ULS00468 {cardinality="1", order="1"} ! putrescine from N-carbamoylputrescine (amidase route) relationship: part_of UPa:ULS00468 ! putrescine from N-carbamoylputrescine (amidase route) [Term] id: UPa:UER00287 name: putrescine from agmatine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 agmatine => 1 putrescine + 1 urea." [] xref: EC:3.5.3.11 xref: GO:0008783 "molecular_function:agmatinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00179 ! agmatine relationship: has_input_compound UPa:UPC00179 {cardinality="1", is_alternate="False", is_primary="True"} ! agmatine relationship: has_output_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00086 {cardinality="1", is_alternate="False", is_primary="False"} ! urea relationship: has_output_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: part_of UPa:ULS00112 ! putrescine from agmatine relationship: part_of UPa:ULS00112 {cardinality="1", order="1"} ! putrescine from agmatine [Term] id: UPa:UER00288 name: putrescine from L-ornithine: step 1/1 namespace: enzymatic_reaction def: "1 L-ornithine => 1 CO(2) + 1 putrescine." [] xref: EC:4.1.1.17 xref: GO:0004586 "molecular_function:ornithine decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: part_of UPa:ULS00113 ! putrescine from L-ornithine relationship: part_of UPa:ULS00113 {cardinality="1", order="1"} ! putrescine from L-ornithine [Term] id: UPa:UER00289 name: 4-aminobutanal from putrescine (amine oxidase route): step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 O(2) + 1 putrescine => 1 4-aminobutanal + 1 H(2)O(2) + 1 NH(3)." [] xref: EC:1.4.3.10 xref: GO:0050232 "molecular_function:putrescine oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_input_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00555 ! 4-aminobutanal relationship: has_output_compound UPa:UPC00555 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanal relationship: part_of UPa:ULS00114 ! 4-aminobutanal from putrescine (amine oxidase route) relationship: part_of UPa:ULS00114 {cardinality="1", order="1"} ! 4-aminobutanal from putrescine (amine oxidase route) [Term] id: UPa:UER00290 name: 4-aminobutanal from putrescine (transaminase route): step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 putrescine => 1 4-aminobutanal + 1 L-glutamate." [] xref: EC:2.6.1.82 xref: GO:0033094 "molecular_function:butane-1,4-diamine:2-oxoglutarate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_input_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00555 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanal relationship: has_output_compound UPa:UPC00555 ! 4-aminobutanal relationship: part_of UPa:ULS00115 {cardinality="1", order="1"} ! 4-aminobutanal from putrescine (transaminase route) relationship: part_of UPa:ULS00115 ! 4-aminobutanal from putrescine (transaminase route) [Term] id: UPa:UER00291 name: 1,3-diaminopropane and 4-aminobutanal from spermidine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 acceptor + 1 spermidine => 1 1,3-diaminopropane + 1 4-aminobutanal + 1 reduced acceptor." [] xref: EC:1.5.99.6 xref: GO:0050289 "molecular_function:spermidine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00315 {cardinality="1", is_alternate="False", is_primary="True"} ! spermidine relationship: has_input_compound UPa:UPC00315 ! spermidine relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_output_compound UPa:UPC00555 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanal relationship: has_output_compound UPa:UPC00555 ! 4-aminobutanal relationship: has_output_compound UPa:UPC00986 ! 1,3-diaminopropane relationship: has_output_compound UPa:UPC00986 {cardinality="1", is_alternate="False", is_primary="True"} ! 1,3-diaminopropane relationship: part_of UPa:ULS00135 ! 1,3-diaminopropane and 4-aminobutanal from spermidine relationship: part_of UPa:ULS00135 {cardinality="1", order="1"} ! 1,3-diaminopropane and 4-aminobutanal from spermidine [Term] id: UPa:UER00292 name: 4-aminobutanoate from 4-aminobutanal: step 1/1 namespace: enzymatic_reaction def: "1 4-aminobutanal + 1 H(2)O + 1 NAD(+) => 1 4-aminobutanoate + 1 H(+) + 1 NADH." [] xref: EC:1.2.1.19 xref: GO:0019145 "molecular_function:aminobutyraldehyde dehydrogenase activity" xref: GO:0033737 "molecular_function:1-pyrroline dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00555 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanal relationship: has_input_compound UPa:UPC00555 ! 4-aminobutanal relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00334 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanoate relationship: has_output_compound UPa:UPC00334 ! 4-aminobutanoate relationship: part_of UPa:ULS00133 {cardinality="1", order="1"} ! 4-aminobutanoate from 4-aminobutanal relationship: part_of UPa:ULS00133 ! 4-aminobutanoate from 4-aminobutanal [Term] id: UPa:UER00293 name: succinate semialdehyde from 4-aminobutanoate: step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 4-aminobutanoate => 1 L-glutamate + 1 succinate semialdehyde." [] xref: EC:2.6.1.19 xref: GO:0003867 "molecular_function:4-aminobutyrate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00334 ! 4-aminobutanoate relationship: has_input_compound UPa:UPC00334 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanoate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00232 ! succinate semialdehyde relationship: has_output_compound UPa:UPC00232 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate semialdehyde relationship: part_of UPa:ULS00134 {cardinality="1", order="1"} ! succinate semialdehyde from 4-aminobutanoate relationship: part_of UPa:ULS00134 ! succinate semialdehyde from 4-aminobutanoate [Term] id: UPa:UER00295 name: XMP from IMP: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 IMP + 1 NAD(+) => 1 H(+) + 1 NADH + 1 XMP." [] xref: EC:1.1.1.205 xref: GO:0003938 "molecular_function:IMP dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00130 ! IMP relationship: has_input_compound UPa:UPC00130 {cardinality="1", is_alternate="False", is_primary="True"} ! IMP relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00655 ! XMP relationship: has_output_compound UPa:UPC00655 {cardinality="1", is_alternate="False", is_primary="True"} ! XMP relationship: part_of UPa:ULS00117 {cardinality="1", order="1"} ! XMP from IMP relationship: part_of UPa:ULS00117 ! XMP from IMP [Term] id: UPa:UER00296 name: GMP from XMP (L-Gln route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 H(2)O + 1 L-glutamine + 1 XMP => 1 AMP + 1 GMP + 1 L-glutamate + 1 diphosphate." [] xref: EC:6.3.5.2 xref: GO:0003921 "molecular_function:GMP synthase activity" xref: GO:0003922 "molecular_function:GMP synthase (glutamine-hydrolyzing) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00655 {cardinality="1", is_alternate="False", is_primary="True"} ! XMP relationship: has_input_compound UPa:UPC00655 ! XMP relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00144 {cardinality="1", is_alternate="False", is_primary="True"} ! GMP relationship: has_output_compound UPa:UPC00144 ! GMP relationship: part_of UPa:ULS00118 {cardinality="1", order="1"} ! GMP from XMP (L-Gln route) relationship: part_of UPa:ULS00118 ! GMP from XMP (L-Gln route) [Term] id: UPa:UER00297 name: GMP from XMP (ammonia route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 NH(3) + 1 XMP => 1 AMP + 1 GMP + 1 diphosphate." [] xref: EC:6.3.5.2 xref: GO:0003921 "molecular_function:GMP synthase activity" xref: GO:0003922 "molecular_function:GMP synthase (glutamine-hydrolyzing) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00655 {cardinality="1", is_alternate="False", is_primary="True"} ! XMP relationship: has_input_compound UPa:UPC00655 ! XMP relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00144 {cardinality="1", is_alternate="False", is_primary="True"} ! GMP relationship: has_output_compound UPa:UPC00144 ! GMP relationship: part_of UPa:ULS00119 {cardinality="1", order="1"} ! GMP from XMP (ammonia route) relationship: part_of UPa:ULS00119 ! GMP from XMP (ammonia route) [Term] id: UPa:UER00298 name: pyridoxal 5'-phosphate from pyridoxal: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 pyridoxal => 1 ADP + 1 pyridoxal 5'-phosphate." [] xref: EC:2.7.1.35 xref: GO:0008478 "molecular_function:pyridoxal kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00250 ! pyridoxal relationship: has_input_compound UPa:UPC00250 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxal relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00018 ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00018 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxal 5'-phosphate relationship: part_of UPa:ULS00120 {cardinality="1", order="1"} ! pyridoxal 5'-phosphate from pyridoxal relationship: part_of UPa:ULS00120 ! pyridoxal 5'-phosphate from pyridoxal [Term] id: UPa:UER00299 name: pyridoxamine 5'-phosphate from pyridoxamine: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 pyridoxamine => 1 ADP + 1 pyridoxamine 5'-phosphate." [] xref: EC:2.7.1.35 xref: GO:0008478 "molecular_function:pyridoxal kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00534 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxamine relationship: has_input_compound UPa:UPC00534 ! pyridoxamine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00647 ! pyridoxamine 5'-phosphate relationship: has_output_compound UPa:UPC00647 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxamine 5'-phosphate relationship: part_of UPa:ULS00121 {cardinality="1", order="1"} ! pyridoxamine 5'-phosphate from pyridoxamine relationship: part_of UPa:ULS00121 ! pyridoxamine 5'-phosphate from pyridoxamine [Term] id: UPa:UER00300 name: pyridoxine 5'-phosphate from pyridoxine: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 pyridoxine => 1 ADP + 1 pyridoxine 5'-phosphate." [] xref: EC:2.7.1.35 xref: GO:0008478 "molecular_function:pyridoxal kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00314 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxine relationship: has_input_compound UPa:UPC00314 ! pyridoxine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00627 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00627 ! pyridoxine 5'-phosphate relationship: part_of UPa:ULS00122 {cardinality="1", order="1"} ! pyridoxine 5'-phosphate from pyridoxine relationship: part_of UPa:ULS00122 ! pyridoxine 5'-phosphate from pyridoxine [Term] id: UPa:UER00301 name: pyridoxal from pyridoxal 5'-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 pyridoxal 5'-phosphate => 1 phosphate + 1 pyridoxal." [] xref: EC:3.1.3.74 xref: GO:0033883 "molecular_function:pyridoxal phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00018 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxal 5'-phosphate relationship: has_input_compound UPa:UPC00018 ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00250 ! pyridoxal relationship: has_output_compound UPa:UPC00250 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxal relationship: part_of UPa:ULS00123 ! pyridoxal from pyridoxal 5'-phosphate relationship: part_of UPa:ULS00123 {cardinality="1", order="1"} ! pyridoxal from pyridoxal 5'-phosphate [Term] id: UPa:UER00302 name: pyridoxamine from pyridoxamine 5'-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 pyridoxamine 5'-phosphate => 1 phosphate + 1 pyridoxamine." [] xref: EC:3.1.3.74 xref: GO:0033883 "molecular_function:pyridoxal phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00647 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxamine 5'-phosphate relationship: has_input_compound UPa:UPC00647 ! pyridoxamine 5'-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00534 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxamine relationship: has_output_compound UPa:UPC00534 ! pyridoxamine relationship: part_of UPa:ULS00124 ! pyridoxamine from pyridoxamine 5'-phosphate relationship: part_of UPa:ULS00124 {cardinality="1", order="1"} ! pyridoxamine from pyridoxamine 5'-phosphate [Term] id: UPa:UER00303 name: pyridoxine from pyridoxine 5'-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 pyridoxine 5'-phosphate => 1 phosphate + 1 pyridoxine." [] xref: EC:3.1.3.74 xref: GO:0033883 "molecular_function:pyridoxal phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00627 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxine 5'-phosphate relationship: has_input_compound UPa:UPC00627 ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00314 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxine relationship: has_output_compound UPa:UPC00314 ! pyridoxine relationship: part_of UPa:ULS00125 {cardinality="1", order="1"} ! pyridoxine from pyridoxine 5'-phosphate relationship: part_of UPa:ULS00125 ! pyridoxine from pyridoxine 5'-phosphate [Term] id: UPa:UER00304 name: pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 O(2) + 1 pyridoxamine 5'-phosphate => 1 H(2)O(2) + 1 NH(3) + 1 pyridoxal 5'-phosphate." [] xref: EC:1.4.3.5 xref: GO:0004733 "molecular_function:pyridoxamine-phosphate oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00647 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxamine 5'-phosphate relationship: has_input_compound UPa:UPC00647 ! pyridoxamine 5'-phosphate relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00018 ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00018 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: part_of UPa:ULS00126 {cardinality="1", order="1"} ! pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate relationship: part_of UPa:ULS00126 ! pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate [Term] id: UPa:UER00305 name: pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 O(2) + 1 pyridoxine 5'-phosphate => 1 H(2)O(2) + 1 pyridoxal 5'-phosphate." [] xref: EC:1.4.3.5 xref: GO:0004733 "molecular_function:pyridoxamine-phosphate oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00627 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxine 5'-phosphate relationship: has_input_compound UPa:UPC00627 ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00018 ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00018 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: part_of UPa:ULS00127 {cardinality="1", order="1"} ! pyridoxal 5'-phosphate from pyridoxine 5'-phosphate relationship: part_of UPa:ULS00127 ! pyridoxal 5'-phosphate from pyridoxine 5'-phosphate [Term] id: UPa:UER00306 name: pyridoxal from pyridoxamine: step 1/1 namespace: enzymatic_reaction def: "1 pyridoxamine + 1 pyruvate => 1 L-alanine + 1 pyridoxal." [] xref: EC:2.6.1.30 xref: GO:0047300 "molecular_function:pyridoxamine-pyruvate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_input_compound UPa:UPC00534 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxamine relationship: has_input_compound UPa:UPC00534 ! pyridoxamine relationship: has_output_compound UPa:UPC00041 ! L-alanine relationship: has_output_compound UPa:UPC00041 {cardinality="1", is_alternate="False", is_primary="False"} ! L-alanine relationship: has_output_compound UPa:UPC00250 ! pyridoxal relationship: has_output_compound UPa:UPC00250 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxal relationship: part_of UPa:ULS00128 {cardinality="1", order="1"} ! pyridoxal from pyridoxamine relationship: part_of UPa:ULS00128 ! pyridoxal from pyridoxamine [Term] id: UPa:UER00307 name: pyridoxal from pyridoxine (dehydrogenase route): step 1/1 namespace: enzymatic_reaction def: "1 NADP(+) + 1 pyridoxine => 1 H(+) + 1 NADPH + 1 pyridoxal." [] xref: EC:1.1.1.65 xref: GO:0050236 "molecular_function:pyridoxine:NADP 4-dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00314 ! pyridoxine relationship: has_input_compound UPa:UPC00314 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxine relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00250 ! pyridoxal relationship: has_output_compound UPa:UPC00250 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxal relationship: part_of UPa:ULS00129 {cardinality="1", order="1"} ! pyridoxal from pyridoxine (dehydrogenase route) relationship: part_of UPa:ULS00129 ! pyridoxal from pyridoxine (dehydrogenase route) [Term] id: UPa:UER00308 name: 3-carboxy-cis,cis-muconate from 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate: step 1/1 namespace: enzymatic_reaction def: "1 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate => 1 3-carboxy-cis,cis-muconate." [] xref: EC:5.5.1.5 xref: GO:0047768 "molecular_function:carboxy-cis,cis-muconate cyclase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04553 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_input_compound UPa:UPC04553 ! 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_output_compound UPa:UPC01163 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-carboxy-cis,cis-muconate relationship: has_output_compound UPa:UPC01163 ! 3-carboxy-cis,cis-muconate relationship: part_of UPa:ULS00131 {cardinality="1", order="1"} ! 3-carboxy-cis,cis-muconate from 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: part_of UPa:ULS00131 ! 3-carboxy-cis,cis-muconate from 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate [Term] id: UPa:UER00309 name: pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5 namespace: enzymatic_reaction def: "1 D-erythrose 4-phosphate + 1 H(2)O + 1 NAD(+) => 1 4-phospho-D-erythronate + 1 H(+) + 1 NADH." [] xref: EC:1.2.1.72 xref: GO:0048001 "molecular_function:erythrose-4-phosphate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00279 ! D-erythrose 4-phosphate relationship: has_input_compound UPa:UPC00279 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC03393 ! 4-phospho-D-erythronate relationship: has_output_compound UPa:UPC03393 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-phospho-D-erythronate relationship: part_of UPa:ULS00132 {cardinality="1", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate relationship: part_of UPa:ULS00132 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate [Term] id: UPa:UER00310 name: pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 2/5 namespace: enzymatic_reaction def: "1 4-phospho-D-erythronate + 1 NAD(+) => 1 (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.290 xref: GO:0033711 "molecular_function:4-phosphoerythronate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC03393 ! 4-phospho-D-erythronate relationship: has_input_compound UPa:UPC03393 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-phospho-D-erythronate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC06054 ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid relationship: has_output_compound UPa:UPC06054 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid relationship: part_of UPa:ULS00132 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate relationship: part_of UPa:ULS00132 {cardinality="1", order="2"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate [Term] id: UPa:UER00311 name: pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5 namespace: enzymatic_reaction def: "1 (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid + 1 L-glutamate => 1 2-oxoglutarate + 1 4-(phosphonooxy)-L-threonine." [] xref: EC:2.6.1.52 xref: GO:0004648 "molecular_function:O-phospho-L-serine:2-oxoglutarate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC06054 ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid relationship: has_input_compound UPa:UPC06054 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC06055 ! 4-(phosphonooxy)-L-threonine relationship: has_output_compound UPa:UPC06055 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-(phosphonooxy)-L-threonine relationship: part_of UPa:ULS00132 {cardinality="1", order="3"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate relationship: part_of UPa:ULS00132 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate [Term] id: UPa:UER00312 name: pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5 namespace: enzymatic_reaction def: "1 4-(phosphonooxy)-L-threonine + 1 NAD(+) => 1 3-amino-2-oxopropyl phosphate + 1 CO(2) + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.262 xref: GO:0050570 "molecular_function:4-hydroxythreonine-4-phosphate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC06055 ! 4-(phosphonooxy)-L-threonine relationship: has_input_compound UPa:UPC06055 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-(phosphonooxy)-L-threonine relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC11638 ! 3-amino-2-oxopropyl phosphate relationship: has_output_compound UPa:UPC11638 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-amino-2-oxopropyl phosphate relationship: part_of UPa:ULS00132 {cardinality="1", order="4"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate relationship: part_of UPa:ULS00132 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate [Term] id: UPa:UER00313 name: pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5 namespace: enzymatic_reaction def: "1 1-deoxy-D-xylulose 5-phosphate + 1 3-amino-2-oxopropyl phosphate => 2 H(2)O + 1 phosphate + 1 pyridoxine 5'-phosphate." [] xref: EC:2.6.99.2 xref: GO:0033856 "molecular_function:pyridoxine 5'-phosphate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC11437 {cardinality="1", is_alternate="False", is_primary="False"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC11638 ! 3-amino-2-oxopropyl phosphate relationship: has_input_compound UPa:UPC11638 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-amino-2-oxopropyl phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00627 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00627 ! pyridoxine 5'-phosphate relationship: part_of UPa:ULS00132 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate relationship: part_of UPa:ULS00132 {cardinality="1", order="5"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate [Term] id: UPa:UER00314 name: spermidine from putrescine: step 1/1 namespace: enzymatic_reaction def: "1 S-adenosylmethioninamine + 1 putrescine => 1 S-methyl-5'-thioadenosine + 1 spermidine." [] xref: EC:2.5.1.16 xref: GO:0004766 "molecular_function:spermidine synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_input_compound UPa:UPC01137 ! S-adenosylmethioninamine relationship: has_input_compound UPa:UPC01137 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosylmethioninamine relationship: has_output_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00170 {cardinality="1", is_alternate="False", is_primary="False"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00315 ! spermidine relationship: has_output_compound UPa:UPC00315 {cardinality="1", is_alternate="False", is_primary="True"} ! spermidine relationship: part_of UPa:ULS00136 ! spermidine from putrescine relationship: part_of UPa:ULS00136 {cardinality="1", order="1"} ! spermidine from putrescine [Term] id: UPa:UER00315 name: spermine from spermidine: step 1/1 namespace: enzymatic_reaction def: "1 S-adenosylmethioninamine + 1 spermidine => 1 S-methyl-5'-thioadenosine + 1 spermine." [] xref: EC:2.5.1.22 xref: GO:0016768 "molecular_function:spermine synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00315 {cardinality="1", is_alternate="False", is_primary="True"} ! spermidine relationship: has_input_compound UPa:UPC00315 ! spermidine relationship: has_input_compound UPa:UPC01137 ! S-adenosylmethioninamine relationship: has_input_compound UPa:UPC01137 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosylmethioninamine relationship: has_output_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00170 {cardinality="1", is_alternate="False", is_primary="False"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00750 {cardinality="1", is_alternate="False", is_primary="True"} ! spermine relationship: has_output_compound UPa:UPC00750 ! spermine relationship: part_of UPa:ULS00137 ! spermine from spermidine relationship: part_of UPa:ULS00137 {cardinality="1", order="1"} ! spermine from spermidine [Term] id: UPa:UER00316 name: 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2 namespace: enzymatic_reaction def: "1 H(+) + 1 L-glutamyl-tRNA(Glu) + 1 NADPH => 1 (S)-4-amino-5-oxopentanoic acid + 1 NADP(+) + 1 tRNA(Glu)." [] xref: EC:1.2.1.70 xref: GO:0008883 "molecular_function:glutamyl-tRNA reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC02987 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamyl-tRNA(Glu) relationship: has_input_compound UPa:UPC02987 ! L-glutamyl-tRNA(Glu) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC01641 {cardinality="1", is_alternate="False", is_primary="False"} ! tRNA(Glu) relationship: has_output_compound UPa:UPC01641 ! tRNA(Glu) relationship: has_output_compound UPa:UPC03741 ! (S)-4-amino-5-oxopentanoic acid relationship: has_output_compound UPa:UPC03741 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-4-amino-5-oxopentanoic acid relationship: part_of UPa:ULS00138 ! 5-aminolevulinate from L-glutamyl-tRNA(Glu) relationship: part_of UPa:ULS00138 {cardinality="1", order="1"} ! 5-aminolevulinate from L-glutamyl-tRNA(Glu) [Term] id: UPa:UER00317 name: 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2 namespace: enzymatic_reaction def: "1 (S)-4-amino-5-oxopentanoic acid => 1 5-aminolevulinate." [] xref: EC:5.4.3.8 xref: GO:0042286 "molecular_function:glutamate-1-semialdehyde 2,1-aminomutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03741 ! (S)-4-amino-5-oxopentanoic acid relationship: has_input_compound UPa:UPC03741 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-4-amino-5-oxopentanoic acid relationship: has_output_compound UPa:UPC00430 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-aminolevulinate relationship: has_output_compound UPa:UPC00430 ! 5-aminolevulinate relationship: part_of UPa:ULS00138 ! 5-aminolevulinate from L-glutamyl-tRNA(Glu) relationship: part_of UPa:ULS00138 {cardinality="1", order="2"} ! 5-aminolevulinate from L-glutamyl-tRNA(Glu) [Term] id: UPa:UER00318 name: coproporphyrinogen-III from 5-aminolevulinate: step 1/4 namespace: enzymatic_reaction def: "2 5-aminolevulinate => 2 H(2)O + 1 porphobilinogen." [] xref: EC:4.2.1.24 xref: GO:0004655 "molecular_function:porphobilinogen synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00430 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-aminolevulinate relationship: has_input_compound UPa:UPC00430 ! 5-aminolevulinate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00931 {cardinality="1", is_alternate="False", is_primary="True"} ! porphobilinogen relationship: has_output_compound UPa:UPC00931 ! porphobilinogen relationship: part_of UPa:ULS00172 ! coproporphyrinogen-III from 5-aminolevulinate relationship: part_of UPa:ULS00172 {cardinality="1", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate [Term] id: UPa:UER00319 name: coproporphyrinogen-III from 5-aminolevulinate: step 2/4 namespace: enzymatic_reaction def: "1 H(2)O + 4 porphobilinogen => 4 NH(3) + 1 hydroxymethylbilane." [] xref: EC:2.5.1.61 xref: GO:0004418 "molecular_function:hydroxymethylbilane synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00931 {cardinality="1", is_alternate="False", is_primary="True"} ! porphobilinogen relationship: has_input_compound UPa:UPC00931 ! porphobilinogen relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC01024 {cardinality="1", is_alternate="False", is_primary="True"} ! hydroxymethylbilane relationship: has_output_compound UPa:UPC01024 ! hydroxymethylbilane relationship: part_of UPa:ULS00172 ! coproporphyrinogen-III from 5-aminolevulinate relationship: part_of UPa:ULS00172 {cardinality="1", order="2"} ! coproporphyrinogen-III from 5-aminolevulinate [Term] id: UPa:UER00320 name: coproporphyrinogen-III from 5-aminolevulinate: step 3/4 namespace: enzymatic_reaction def: "1 hydroxymethylbilane => 1 H(2)O + 1 uroporphyrinogen III." [] xref: EC:4.2.1.75 xref: GO:0004852 "molecular_function:uroporphyrinogen-III synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01024 {cardinality="1", is_alternate="False", is_primary="True"} ! hydroxymethylbilane relationship: has_input_compound UPa:UPC01024 ! hydroxymethylbilane relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC01051 ! uroporphyrinogen III relationship: has_output_compound UPa:UPC01051 {cardinality="1", is_alternate="False", is_primary="True"} ! uroporphyrinogen III relationship: part_of UPa:ULS00172 {cardinality="1", order="3"} ! coproporphyrinogen-III from 5-aminolevulinate relationship: part_of UPa:ULS00172 ! coproporphyrinogen-III from 5-aminolevulinate [Term] id: UPa:UER00321 name: coproporphyrinogen-III from 5-aminolevulinate: step 4/4 namespace: enzymatic_reaction def: "1 uroporphyrinogen III => 4 CO(2) + 1 coproporphyrinogen-III." [] xref: EC:4.1.1.37 xref: GO:0004853 "molecular_function:uroporphyrinogen decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01051 ! uroporphyrinogen III relationship: has_input_compound UPa:UPC01051 {cardinality="1", is_alternate="False", is_primary="True"} ! uroporphyrinogen III relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC03263 ! coproporphyrinogen-III relationship: has_output_compound UPa:UPC03263 {cardinality="1", is_alternate="False", is_primary="True"} ! coproporphyrinogen-III relationship: part_of UPa:ULS00172 {cardinality="1", order="4"} ! coproporphyrinogen-III from 5-aminolevulinate relationship: part_of UPa:ULS00172 ! coproporphyrinogen-III from 5-aminolevulinate [Term] id: UPa:UER00322 name: protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1 namespace: enzymatic_reaction def: "1 O(2) + 1 coproporphyrinogen-III => 2 CO(2) + 2 H(2)O + 1 protoporphyrinogen-IX." [] xref: EC:1.3.3.3 xref: GO:0004109 "molecular_function:coproporphyrinogen oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC03263 ! coproporphyrinogen-III relationship: has_input_compound UPa:UPC03263 {cardinality="1", is_alternate="False", is_primary="True"} ! coproporphyrinogen-III relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC01079 ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC01079 {cardinality="1", is_alternate="False", is_primary="True"} ! protoporphyrinogen-IX relationship: part_of UPa:ULS00139 ! protoporphyrinogen-IX from coproporphyrinogen-III (O2 route) relationship: part_of UPa:ULS00139 {cardinality="1", order="1"} ! protoporphyrinogen-IX from coproporphyrinogen-III (O2 route) [Term] id: UPa:UER00323 name: protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1 namespace: enzymatic_reaction def: "2 S-adenosyl-L-methionine + 1 coproporphyrinogen-III => 2 5'-deoxyadenosine + 2 CO(2) + 2 L-methionine + 1 protoporphyrinogen-IX." [] xref: EC:1.3.99.22 xref: GO:0051989 "molecular_function:coproporphyrinogen dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC03263 ! coproporphyrinogen-III relationship: has_input_compound UPa:UPC03263 {cardinality="1", is_alternate="False", is_primary="True"} ! coproporphyrinogen-III relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="False"} ! L-methionine relationship: has_output_compound UPa:UPC01079 ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC01079 {cardinality="1", is_alternate="False", is_primary="True"} ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC05198 ! 5'-deoxyadenosine relationship: has_output_compound UPa:UPC05198 {cardinality="1", is_alternate="False", is_primary="False"} ! 5'-deoxyadenosine relationship: part_of UPa:ULS00140 {cardinality="1", order="1"} ! protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route) relationship: part_of UPa:ULS00140 ! protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route) [Term] id: UPa:UER00324 name: protoporphyrin-IX from protoporphyrinogen-IX: step 1/1 namespace: enzymatic_reaction def: "3 O(2) + 1 protoporphyrinogen-IX => 3 H(2)O(2) + 1 protoporphyrin-IX." [] xref: EC:1.3.3.4 xref: GO:0004729 "molecular_function:oxygen-dependent protoporphyrinogen oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC01079 ! protoporphyrinogen-IX relationship: has_input_compound UPa:UPC01079 {cardinality="1", is_alternate="False", is_primary="True"} ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC02191 {cardinality="1", is_alternate="False", is_primary="True"} ! protoporphyrin-IX relationship: has_output_compound UPa:UPC02191 ! protoporphyrin-IX relationship: part_of UPa:ULS00141 {cardinality="1", order="1"} ! protoporphyrin-IX from protoporphyrinogen-IX relationship: part_of UPa:ULS00141 ! protoporphyrin-IX from protoporphyrinogen-IX [Term] id: UPa:UER00325 name: protoheme from protoporphyrin-IX: step 1/1 namespace: enzymatic_reaction def: "1 Fe2+ + 1 protoporphyrin-IX => 2 H(+) + 1 protoheme." [] xref: EC:4.99.1.1 xref: GO:0004325 "molecular_function:ferrochelatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC02191 {cardinality="1", is_alternate="False", is_primary="True"} ! protoporphyrin-IX relationship: has_input_compound UPa:UPC02191 ! protoporphyrin-IX relationship: has_input_compound UPa:UPC14818 ! Fe2+ relationship: has_input_compound UPa:UPC14818 {cardinality="1", is_alternate="False", is_primary="False"} ! Fe2+ relationship: has_output_compound UPa:UPC00032 ! protoheme relationship: has_output_compound UPa:UPC00032 {cardinality="1", is_alternate="False", is_primary="True"} ! protoheme relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: part_of UPa:ULS00175 {cardinality="1", order="1"} ! protoheme from protoporphyrin-IX relationship: part_of UPa:ULS00175 ! protoheme from protoporphyrin-IX [Term] id: UPa:UER00326 name: iminoaspartate from L-aspartate (oxidase route): step 1/1 namespace: enzymatic_reaction def: "1 L-aspartate + 1 O(2) => 1 H(2)O(2) + 1 iminoaspartate." [] xref: EC:1.4.3.16 xref: GO:0008734 "molecular_function:L-aspartate oxidase activity" xref: GO:0044318 "molecular_function:L-aspartate:fumarate oxidoreductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC05840 ! iminoaspartate relationship: has_output_compound UPa:UPC05840 {cardinality="1", is_alternate="False", is_primary="True"} ! iminoaspartate relationship: part_of UPa:ULS00142 ! iminoaspartate from L-aspartate (oxidase route) relationship: part_of UPa:ULS00142 {cardinality="1", order="1"} ! iminoaspartate from L-aspartate (oxidase route) [Term] id: UPa:UER00327 name: quinolinate from iminoaspartate: step 1/1 namespace: enzymatic_reaction def: "1 glycerone phosphate + 1 iminoaspartate => 2 H(2)O + 1 phosphate + 1 quinolinate." [] xref: EC:2.5.1.72 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="False"} ! glycerone phosphate relationship: has_input_compound UPa:UPC00111 ! glycerone phosphate relationship: has_input_compound UPa:UPC05840 ! iminoaspartate relationship: has_input_compound UPa:UPC05840 {cardinality="1", is_alternate="False", is_primary="True"} ! iminoaspartate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC03722 {cardinality="1", is_alternate="False", is_primary="True"} ! quinolinate relationship: has_output_compound UPa:UPC03722 ! quinolinate relationship: part_of UPa:ULS00221 ! quinolinate from iminoaspartate relationship: part_of UPa:ULS00221 {cardinality="1", order="1"} ! quinolinate from iminoaspartate [Term] id: UPa:UER00328 name: quinolinate from L-kynurenine: step 1/3 namespace: enzymatic_reaction def: "1 H(+) + 1 L-kynurenine + 1 NADPH + 1 O(2) => 1 3-hydroxy-L-kynurenine + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.9 xref: GO:0004502 "molecular_function:kynurenine 3-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00328 {cardinality="1", is_alternate="False", is_primary="True"} ! L-kynurenine relationship: has_input_compound UPa:UPC00328 ! L-kynurenine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC03227 ! 3-hydroxy-L-kynurenine relationship: has_output_compound UPa:UPC03227 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxy-L-kynurenine relationship: part_of UPa:ULS00143 {cardinality="1", order="1"} ! quinolinate from L-kynurenine relationship: part_of UPa:ULS00143 ! quinolinate from L-kynurenine [Term] id: UPa:UER00329 name: quinolinate from L-kynurenine: step 2/3 namespace: enzymatic_reaction def: "1 3-hydroxy-L-kynurenine + 1 H(2)O => 1 3-hydroxyanthranilate + 1 L-alanine." [] xref: EC:3.7.1.3 xref: GO:0030429 "molecular_function:kynureninase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC03227 ! 3-hydroxy-L-kynurenine relationship: has_input_compound UPa:UPC03227 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxy-L-kynurenine relationship: has_output_compound UPa:UPC00041 ! L-alanine relationship: has_output_compound UPa:UPC00041 {cardinality="1", is_alternate="False", is_primary="False"} ! L-alanine relationship: has_output_compound UPa:UPC00632 ! 3-hydroxyanthranilate relationship: has_output_compound UPa:UPC00632 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxyanthranilate relationship: part_of UPa:ULS00143 {cardinality="1", order="2"} ! quinolinate from L-kynurenine relationship: part_of UPa:ULS00143 ! quinolinate from L-kynurenine [Term] id: UPa:UER00330 name: quinolinate from L-kynurenine: step 3/3 namespace: enzymatic_reaction def: "1 3-hydroxyanthranilate + 1 O(2) => 1 H(2)O + 1 quinolinate." [] xref: EC:1.13.11.6 xref: GO:0000334 "molecular_function:3-hydroxyanthranilate 3,4-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00632 ! 3-hydroxyanthranilate relationship: has_input_compound UPa:UPC00632 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxyanthranilate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC03722 ! quinolinate relationship: has_output_compound UPa:UPC03722 {cardinality="1", is_alternate="False", is_primary="True"} ! quinolinate relationship: part_of UPa:ULS00143 {cardinality="1", order="3"} ! quinolinate from L-kynurenine relationship: part_of UPa:ULS00143 ! quinolinate from L-kynurenine [Term] id: UPa:UER00331 name: nicotinate D-ribonucleotide from quinolinate: step 1/1 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 quinolinate => 1 CO(2) + 1 diphosphate + 1 nicotinate D-ribonucleotide." [] xref: EC:2.4.2.19 xref: GO:0004514 "molecular_function:nicotinate-nucleotide diphosphorylase (carboxylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC03722 {cardinality="1", is_alternate="False", is_primary="True"} ! quinolinate relationship: has_input_compound UPa:UPC03722 ! quinolinate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC01185 ! nicotinate D-ribonucleotide relationship: has_output_compound UPa:UPC01185 {cardinality="1", is_alternate="False", is_primary="True"} ! nicotinate D-ribonucleotide relationship: part_of UPa:ULS00144 {cardinality="1", order="1"} ! nicotinate D-ribonucleotide from quinolinate relationship: part_of UPa:ULS00144 ! nicotinate D-ribonucleotide from quinolinate [Term] id: UPa:UER00332 name: deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 nicotinate D-ribonucleotide => 1 deamido-NAD(+) + 1 diphosphate." [] xref: EC:2.7.7.18 xref: GO:0004515 "molecular_function:nicotinate-nucleotide adenylyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01185 {cardinality="1", is_alternate="False", is_primary="True"} ! nicotinate D-ribonucleotide relationship: has_input_compound UPa:UPC01185 ! nicotinate D-ribonucleotide relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00857 ! deamido-NAD(+) relationship: has_output_compound UPa:UPC00857 {cardinality="1", is_alternate="False", is_primary="True"} ! deamido-NAD(+) relationship: part_of UPa:ULS00222 ! deamido-NAD(+) from nicotinate D-ribonucleotide relationship: part_of UPa:ULS00222 {cardinality="1", order="1"} ! deamido-NAD(+) from nicotinate D-ribonucleotide [Term] id: UPa:UER00333 name: NAD(+) from deamido-NAD(+) (ammonia route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 NH(3) + 1 deamido-NAD(+) => 1 AMP + 1 NAD(+) + 1 diphosphate." [] xref: EC:6.3.1.5 xref: GO:0008795 "molecular_function:NAD+ synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00857 ! deamido-NAD(+) relationship: has_input_compound UPa:UPC00857 {cardinality="1", is_alternate="False", is_primary="True"} ! deamido-NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="True"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: part_of UPa:ULS00145 {cardinality="1", order="1"} ! NAD(+) from deamido-NAD(+) (ammonia route) relationship: part_of UPa:ULS00145 ! NAD(+) from deamido-NAD(+) (ammonia route) [Term] id: UPa:UER00334 name: NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 H(2)O + 1 L-glutamine + 1 deamido-NAD(+) => 1 AMP + 1 L-glutamate + 1 NAD(+) + 1 diphosphate." [] xref: EC:6.3.5.1 xref: GO:0003952 "molecular_function:NAD+ synthase (glutamine-hydrolyzing) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00857 ! deamido-NAD(+) relationship: has_input_compound UPa:UPC00857 {cardinality="1", is_alternate="False", is_primary="True"} ! deamido-NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="True"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: part_of UPa:ULS00146 ! NAD(+) from deamido-NAD(+) (L-Gln route) relationship: part_of UPa:ULS00146 {cardinality="1", order="1"} ! NAD(+) from deamido-NAD(+) (L-Gln route) [Term] id: UPa:UER00335 name: AMP from IMP: step 1/2 namespace: enzymatic_reaction def: "1 GTP + 1 IMP + 1 L-aspartate => 1 GDP + 1 N(6)-(1,2-dicarboxyethyl)-AMP + 1 phosphate." [] xref: EC:6.3.4.4 xref: GO:0004019 "molecular_function:adenylosuccinate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00044 {cardinality="1", is_alternate="False", is_primary="False"} ! GTP relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="False"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00130 {cardinality="1", is_alternate="False", is_primary="True"} ! IMP relationship: has_input_compound UPa:UPC00130 ! IMP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00035 {cardinality="1", is_alternate="False", is_primary="False"} ! GDP relationship: has_output_compound UPa:UPC00035 ! GDP relationship: has_output_compound UPa:UPC03794 ! N(6)-(1,2-dicarboxyethyl)-AMP relationship: has_output_compound UPa:UPC03794 {cardinality="1", is_alternate="False", is_primary="True"} ! N(6)-(1,2-dicarboxyethyl)-AMP relationship: part_of UPa:ULS00147 ! AMP from IMP relationship: part_of UPa:ULS00147 {cardinality="1", order="1"} ! AMP from IMP [Term] id: UPa:UER00336 name: AMP from IMP: step 2/2 namespace: enzymatic_reaction def: "1 N(6)-(1,2-dicarboxyethyl)-AMP => 1 AMP + 1 fumarate." [] xref: EC:4.3.2.2 xref: GO:0004018 "molecular_function:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity" xref: GO:0070626 "molecular_function:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03794 {cardinality="1", is_alternate="False", is_primary="True"} ! N(6)-(1,2-dicarboxyethyl)-AMP relationship: has_input_compound UPa:UPC03794 ! N(6)-(1,2-dicarboxyethyl)-AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="True"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="False"} ! fumarate relationship: part_of UPa:ULS00147 {cardinality="1", order="2"} ! AMP from IMP relationship: part_of UPa:ULS00147 ! AMP from IMP [Term] id: UPa:UER00337 name: acetoacetate and fumarate from L-phenylalanine: step 1/6 namespace: enzymatic_reaction def: "1 L-phenylalanine + 1 O(2) + 1 tetrahydrobiopterin => 1 4a-hydroxytetrahydrobiopterin + 1 L-tyrosine." [] xref: EC:1.14.16.1 xref: GO:0004505 "molecular_function:phenylalanine 4-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine relationship: has_input_compound UPa:UPC00079 {cardinality="1", is_alternate="False", is_primary="True"} ! L-phenylalanine relationship: has_input_compound UPa:UPC00272 {cardinality="1", is_alternate="False", is_primary="False"} ! tetrahydrobiopterin relationship: has_input_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00082 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tyrosine relationship: has_output_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC15522 ! 4a-hydroxytetrahydrobiopterin relationship: has_output_compound UPa:UPC15522 {cardinality="1", is_alternate="False", is_primary="False"} ! 4a-hydroxytetrahydrobiopterin relationship: part_of UPa:ULS00148 {cardinality="1", order="1"} ! acetoacetate and fumarate from L-phenylalanine relationship: part_of UPa:ULS00148 ! acetoacetate and fumarate from L-phenylalanine [Term] id: UPa:UER00338 name: acetoacetate and fumarate from L-phenylalanine: step 2/6 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 L-tyrosine => 1 (4-hydroxyphenyl)pyruvate + 1 L-glutamate." [] xref: EC:2.6.1.5 xref: GO:0004838 "molecular_function:L-tyrosine:2-oxoglutarate aminotransferase activity" xref: GO:0080130 "molecular_function:L-phenylalanine:2-oxoglutarate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00082 ! L-tyrosine relationship: has_input_compound UPa:UPC00082 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tyrosine relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC01179 {cardinality="1", is_alternate="False", is_primary="True"} ! (4-hydroxyphenyl)pyruvate relationship: part_of UPa:ULS00148 ! acetoacetate and fumarate from L-phenylalanine relationship: part_of UPa:ULS00148 {cardinality="1", order="2"} ! acetoacetate and fumarate from L-phenylalanine [Term] id: UPa:UER00339 name: acetoacetate and fumarate from L-phenylalanine: step 4/6 namespace: enzymatic_reaction def: "1 O(2) + 1 homogentisate => 1 4-maleylacetoacetate." [] xref: EC:1.13.11.5 xref: GO:0004411 "molecular_function:homogentisate 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00544 {cardinality="1", is_alternate="False", is_primary="True"} ! homogentisate relationship: has_input_compound UPa:UPC00544 ! homogentisate relationship: has_output_compound UPa:UPC01036 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-maleylacetoacetate relationship: has_output_compound UPa:UPC01036 ! 4-maleylacetoacetate relationship: part_of UPa:ULS00148 ! acetoacetate and fumarate from L-phenylalanine relationship: part_of UPa:ULS00148 {cardinality="1", order="4"} ! acetoacetate and fumarate from L-phenylalanine [Term] id: UPa:UER00340 name: acetoacetate and fumarate from L-phenylalanine: step 5/6 namespace: enzymatic_reaction def: "1 4-maleylacetoacetate => 1 4-fumarylacetoacetate." [] xref: EC:5.2.1.2 xref: GO:0016034 "molecular_function:maleylacetoacetate isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01036 ! 4-maleylacetoacetate relationship: has_input_compound UPa:UPC01036 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-maleylacetoacetate relationship: has_output_compound UPa:UPC01061 ! 4-fumarylacetoacetate relationship: has_output_compound UPa:UPC01061 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-fumarylacetoacetate relationship: part_of UPa:ULS00148 ! acetoacetate and fumarate from L-phenylalanine relationship: part_of UPa:ULS00148 {cardinality="1", order="5"} ! acetoacetate and fumarate from L-phenylalanine [Term] id: UPa:UER00341 name: acetoacetate and fumarate from L-phenylalanine: step 6/6 namespace: enzymatic_reaction def: "1 4-fumarylacetoacetate + 1 H(2)O => 1 acetoacetate + 1 fumarate." [] xref: EC:3.7.1.2 xref: GO:0004334 "molecular_function:fumarylacetoacetase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01061 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-fumarylacetoacetate relationship: has_input_compound UPa:UPC01061 ! 4-fumarylacetoacetate relationship: has_output_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="True"} ! fumarate relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00164 {cardinality="1", is_alternate="False", is_primary="True"} ! acetoacetate relationship: has_output_compound UPa:UPC00164 ! acetoacetate relationship: part_of UPa:ULS00148 ! acetoacetate and fumarate from L-phenylalanine relationship: part_of UPa:ULS00148 {cardinality="1", order="6"} ! acetoacetate and fumarate from L-phenylalanine [Term] id: UPa:UER00342 name: L-arogenate from prephenate (L-Asp route): step 1/1 namespace: enzymatic_reaction def: "1 L-aspartate + 1 prephenate => 1 L-arogenate + 1 oxaloacetate." [] xref: EC:2.6.1.78 xref: GO:0033853 "molecular_function:aspartate-prephenate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="False"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00254 {cardinality="1", is_alternate="False", is_primary="True"} ! prephenate relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_output_compound UPa:UPC00036 ! oxaloacetate relationship: has_output_compound UPa:UPC00036 {cardinality="1", is_alternate="False", is_primary="False"} ! oxaloacetate relationship: has_output_compound UPa:UPC00826 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arogenate relationship: has_output_compound UPa:UPC00826 ! L-arogenate relationship: part_of UPa:ULS00149 ! L-arogenate from prephenate (L-Asp route) relationship: part_of UPa:ULS00149 {cardinality="1", order="1"} ! L-arogenate from prephenate (L-Asp route) [Term] id: UPa:UER00343 name: L-arogenate from prephenate (L-Glu route): step 1/1 namespace: enzymatic_reaction def: "1 L-glutamate + 1 prephenate => 1 2-oxoglutarate + 1 L-arogenate." [] xref: EC:2.6.1.79 xref: GO:0033854 "molecular_function:glutamate-prephenate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00254 {cardinality="1", is_alternate="False", is_primary="True"} ! prephenate relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00826 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arogenate relationship: has_output_compound UPa:UPC00826 ! L-arogenate relationship: part_of UPa:ULS00150 ! L-arogenate from prephenate (L-Glu route) relationship: part_of UPa:ULS00150 {cardinality="1", order="1"} ! L-arogenate from prephenate (L-Glu route) [Term] id: UPa:UER00344 name: L-phenylalanine from L-arogenate: step 1/1 namespace: enzymatic_reaction def: "1 L-arogenate => 1 CO(2) + 1 H(2)O + 1 L-phenylalanine." [] xref: EC:4.2.1.91 xref: GO:0047769 "molecular_function:arogenate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00826 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arogenate relationship: has_input_compound UPa:UPC00826 ! L-arogenate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC00079 {cardinality="1", is_alternate="False", is_primary="True"} ! L-phenylalanine relationship: part_of UPa:ULS00151 {cardinality="1", order="1"} ! L-phenylalanine from L-arogenate relationship: part_of UPa:ULS00151 ! L-phenylalanine from L-arogenate [Term] id: UPa:UER00345 name: phenylpyruvate from prephenate: step 1/1 namespace: enzymatic_reaction def: "1 prephenate => 1 CO(2) + 1 H(2)O + 1 phenylpyruvate." [] xref: EC:4.2.1.51 xref: GO:0004664 "molecular_function:prephenate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00254 {cardinality="1", is_alternate="False", is_primary="True"} ! prephenate relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00166 {cardinality="1", is_alternate="False", is_primary="True"} ! phenylpyruvate relationship: has_output_compound UPa:UPC00166 ! phenylpyruvate relationship: part_of UPa:ULS00152 {cardinality="1", order="1"} ! phenylpyruvate from prephenate relationship: part_of UPa:ULS00152 ! phenylpyruvate from prephenate [Term] id: UPa:UER00346 name: L-phenylalanine from phenylpyruvate (PDH route): step 1/1 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 NH(3) + 1 phenylpyruvate => 1 H(2)O + 1 L-phenylalanine + 1 NAD(+)." [] xref: EC:1.4.1.20 xref: GO:0050175 "molecular_function:phenylalanine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00166 ! phenylpyruvate relationship: has_input_compound UPa:UPC00166 {cardinality="1", is_alternate="False", is_primary="True"} ! phenylpyruvate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC00079 {cardinality="1", is_alternate="False", is_primary="True"} ! L-phenylalanine relationship: part_of UPa:ULS00153 ! L-phenylalanine from phenylpyruvate (PDH route) relationship: part_of UPa:ULS00153 {cardinality="1", order="1"} ! L-phenylalanine from phenylpyruvate (PDH route) [Term] id: UPa:UER00347 name: L-phenylalanine from phenylpyruvate (ArAT route): step 1/1 namespace: enzymatic_reaction def: "1 L-glutamate + 1 phenylpyruvate => 1 2-oxoglutarate + 1 L-phenylalanine." [] xref: EC:2.6.1.5 xref: EC:2.6.1.57 xref: GO:0004838 "molecular_function:L-tyrosine:2-oxoglutarate aminotransferase activity" xref: GO:0008793 "molecular_function:aromatic-amino-acid:2-oxoglutarate aminotransferase activity" xref: GO:0080130 "molecular_function:L-phenylalanine:2-oxoglutarate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00166 ! phenylpyruvate relationship: has_input_compound UPa:UPC00166 {cardinality="1", is_alternate="False", is_primary="True"} ! phenylpyruvate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC00079 {cardinality="1", is_alternate="False", is_primary="True"} ! L-phenylalanine relationship: part_of UPa:ULS00154 ! L-phenylalanine from phenylpyruvate (ArAT route) relationship: part_of UPa:ULS00154 {cardinality="1", order="1"} ! L-phenylalanine from phenylpyruvate (ArAT route) [Term] id: UPa:UER00350 name: L-tyrosine from (4-hydroxyphenyl)pyruvate: step 1/1 namespace: enzymatic_reaction def: "1 (4-hydroxyphenyl)pyruvate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-tyrosine." [] xref: EC:2.6.1.57 xref: GO:0008793 "molecular_function:aromatic-amino-acid:2-oxoglutarate aminotransferase activity" xref: GO:0080130 "molecular_function:L-phenylalanine:2-oxoglutarate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC01179 {cardinality="1", is_alternate="False", is_primary="True"} ! (4-hydroxyphenyl)pyruvate relationship: has_input_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00082 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tyrosine relationship: has_output_compound UPa:UPC00082 ! L-tyrosine relationship: part_of UPa:ULS00485 ! L-tyrosine from (4-hydroxyphenyl)pyruvate relationship: part_of UPa:ULS00485 {cardinality="1", order="1"} ! L-tyrosine from (4-hydroxyphenyl)pyruvate [Term] id: UPa:UER00351 name: pimeloyl-CoA from pimelate: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 CoA + 1 pimelate => 1 AMP + 1 diphosphate + 1 pimeloyl-CoA." [] xref: EC:6.2.1.14 xref: GO:0042410 "molecular_function:6-carboxyhexanoate-CoA ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC02656 ! pimelate relationship: has_input_compound UPa:UPC02656 {cardinality="1", is_alternate="False", is_primary="True"} ! pimelate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC01063 {cardinality="1", is_alternate="False", is_primary="True"} ! pimeloyl-CoA relationship: has_output_compound UPa:UPC01063 ! pimeloyl-CoA relationship: part_of UPa:ULS00157 {cardinality="1", order="1"} ! pimeloyl-CoA from pimelate relationship: part_of UPa:ULS00157 ! pimeloyl-CoA from pimelate [Term] id: UPa:UER00352 name: CoA from (R)-pantothenate: step 1/5 namespace: enzymatic_reaction def: "1 (R)-pantothenate + 1 ATP => 1 (R)-4'-phosphopantothenate + 1 ADP." [] xref: EC:2.7.1.33 xref: GO:0004594 "molecular_function:pantothenate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00864 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-pantothenate relationship: has_input_compound UPa:UPC00864 ! (R)-pantothenate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC03492 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-4'-phosphopantothenate relationship: has_output_compound UPa:UPC03492 ! (R)-4'-phosphopantothenate relationship: part_of UPa:ULS00158 {cardinality="1", order="1"} ! CoA from (R)-pantothenate relationship: part_of UPa:ULS00158 ! CoA from (R)-pantothenate [Term] id: UPa:UER00353 name: CoA from (R)-pantothenate: step 2/5 namespace: enzymatic_reaction def: "1 (R)-4'-phosphopantothenate + 1 CTP + 1 L-cysteine => 1 CMP + 1 N-[(R)-4-phosphonopantothenoyl]-L-cysteine + 1 diphosphate." [] xref: EC:6.3.2.5 xref: GO:0004632 "molecular_function:phosphopantothenate--cysteine ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00063 {cardinality="1", is_alternate="False", is_primary="False"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="False"} ! L-cysteine relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC03492 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-4'-phosphopantothenate relationship: has_input_compound UPa:UPC03492 ! (R)-4'-phosphopantothenate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="False"} ! CMP relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC04352 ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine relationship: has_output_compound UPa:UPC04352 {cardinality="1", is_alternate="False", is_primary="True"} ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine relationship: part_of UPa:ULS00158 {cardinality="1", order="2"} ! CoA from (R)-pantothenate relationship: part_of UPa:ULS00158 ! CoA from (R)-pantothenate [Term] id: UPa:UER00354 name: CoA from (R)-pantothenate: step 3/5 namespace: enzymatic_reaction def: "1 N-[(R)-4-phosphonopantothenoyl]-L-cysteine => 1 CO(2) + 1 pantotheine 4'-phosphate." [] xref: EC:4.1.1.36 xref: GO:0004633 "molecular_function:phosphopantothenoylcysteine decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04352 ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine relationship: has_input_compound UPa:UPC04352 {cardinality="1", is_alternate="False", is_primary="True"} ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC01134 ! pantotheine 4'-phosphate relationship: has_output_compound UPa:UPC01134 {cardinality="1", is_alternate="False", is_primary="True"} ! pantotheine 4'-phosphate relationship: part_of UPa:ULS00158 {cardinality="1", order="3"} ! CoA from (R)-pantothenate relationship: part_of UPa:ULS00158 ! CoA from (R)-pantothenate [Term] id: UPa:UER00355 name: CoA from (R)-pantothenate: step 4/5 namespace: enzymatic_reaction def: "1 ATP + 1 pantotheine 4'-phosphate => 1 3'-dephospho-CoA + 1 diphosphate." [] xref: EC:2.7.7.3 xref: GO:0004595 "molecular_function:pantetheine-phosphate adenylyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC01134 {cardinality="1", is_alternate="False", is_primary="True"} ! pantotheine 4'-phosphate relationship: has_input_compound UPa:UPC01134 ! pantotheine 4'-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00882 ! 3'-dephospho-CoA relationship: has_output_compound UPa:UPC00882 {cardinality="1", is_alternate="False", is_primary="True"} ! 3'-dephospho-CoA relationship: part_of UPa:ULS00158 {cardinality="1", order="4"} ! CoA from (R)-pantothenate relationship: part_of UPa:ULS00158 ! CoA from (R)-pantothenate [Term] id: UPa:UER00356 name: CoA from (R)-pantothenate: step 5/5 namespace: enzymatic_reaction def: "1 3'-dephospho-CoA + 1 ATP => 1 ADP + 1 CoA." [] xref: EC:2.7.1.24 xref: GO:0004140 "molecular_function:dephospho-CoA kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00882 ! 3'-dephospho-CoA relationship: has_input_compound UPa:UPC00882 {cardinality="1", is_alternate="False", is_primary="True"} ! 3'-dephospho-CoA relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="True"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: part_of UPa:ULS00158 {cardinality="1", order="5"} ! CoA from (R)-pantothenate relationship: part_of UPa:ULS00158 ! CoA from (R)-pantothenate [Term] id: UPa:UER00357 name: L-proline from L-ornithine: step 1/1 namespace: enzymatic_reaction def: "1 L-ornithine => 1 L-proline + 1 NH(3)." [] xref: EC:4.3.1.12 xref: GO:0008473 "molecular_function:ornithine cyclodeaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_input_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00148 ! L-proline relationship: has_output_compound UPa:UPC00148 {cardinality="1", is_alternate="False", is_primary="True"} ! L-proline relationship: part_of UPa:ULS00159 {cardinality="1", order="1"} ! L-proline from L-ornithine relationship: part_of UPa:ULS00159 ! L-proline from L-ornithine [Term] id: UPa:UER00358 name: L-glutamate 5-semialdehyde from L-ornithine: step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 L-ornithine => 1 L-glutamate + 1 L-glutamate 5-semialdehyde." [] xref: EC:2.6.1.13 xref: GO:0004587 "molecular_function:ornithine-oxo-acid transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_input_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC01165 ! L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC01165 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate 5-semialdehyde relationship: part_of UPa:ULS00160 ! L-glutamate 5-semialdehyde from L-ornithine relationship: part_of UPa:ULS00160 {cardinality="1", order="1"} ! L-glutamate 5-semialdehyde from L-ornithine [Term] id: UPa:UER00359 name: L-glutamate 5-semialdehyde from L-glutamate: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 L-glutamate => 1 ADP + 1 L-glutamyl 5-phosphate." [] xref: EC:2.7.2.11 xref: GO:0004349 "molecular_function:glutamate 5-kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC03287 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamyl 5-phosphate relationship: has_output_compound UPa:UPC03287 ! L-glutamyl 5-phosphate relationship: part_of UPa:ULS00161 ! L-glutamate 5-semialdehyde from L-glutamate relationship: part_of UPa:ULS00161 {cardinality="1", order="1"} ! L-glutamate 5-semialdehyde from L-glutamate [Term] id: UPa:UER00360 name: L-glutamate 5-semialdehyde from L-glutamate: step 2/2 namespace: enzymatic_reaction def: "1 H(+) + 1 L-glutamyl 5-phosphate + 1 NADPH => 1 L-glutamate 5-semialdehyde + 1 NADP(+) + 1 phosphate." [] xref: EC:1.2.1.41 xref: GO:0004350 "molecular_function:glutamate-5-semialdehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC03287 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamyl 5-phosphate relationship: has_input_compound UPa:UPC03287 ! L-glutamyl 5-phosphate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC01165 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC01165 ! L-glutamate 5-semialdehyde relationship: part_of UPa:ULS00161 ! L-glutamate 5-semialdehyde from L-glutamate relationship: part_of UPa:ULS00161 {cardinality="1", order="2"} ! L-glutamate 5-semialdehyde from L-glutamate [Term] id: UPa:UER00361 name: L-proline from L-glutamate 5-semialdehyde: step 1/1 namespace: enzymatic_reaction def: "1 H(+) + 1 L-glutamate 5-semialdehyde + 1 NADH => 1 H(2)O + 1 L-proline + 1 NAD(+)." [] xref: EC:1.5.1.2 xref: GO:0004735 "molecular_function:pyrroline-5-carboxylate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC01165 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate 5-semialdehyde relationship: has_input_compound UPa:UPC01165 ! L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00148 {cardinality="1", is_alternate="False", is_primary="True"} ! L-proline relationship: has_output_compound UPa:UPC00148 ! L-proline relationship: part_of UPa:ULS00162 ! L-proline from L-glutamate 5-semialdehyde relationship: part_of UPa:ULS00162 {cardinality="1", order="1"} ! L-proline from L-glutamate 5-semialdehyde [Term] id: UPa:UER00362 name: acetoacetate and fumarate from L-phenylalanine: step 3/6 namespace: enzymatic_reaction def: "1 (4-hydroxyphenyl)pyruvate + 1 O(2) => 1 CO(2) + 1 homogentisate." [] xref: EC:1.13.11.27 xref: GO:0003868 "molecular_function:4-hydroxyphenylpyruvate dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC01179 {cardinality="1", is_alternate="False", is_primary="True"} ! (4-hydroxyphenyl)pyruvate relationship: has_input_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00544 ! homogentisate relationship: has_output_compound UPa:UPC00544 {cardinality="1", is_alternate="False", is_primary="True"} ! homogentisate relationship: part_of UPa:ULS00148 ! acetoacetate and fumarate from L-phenylalanine relationship: part_of UPa:ULS00148 {cardinality="1", order="3"} ! acetoacetate and fumarate from L-phenylalanine [Term] id: UPa:UER00363 name: N-acetylputrescine from putrescine: step 1/1 namespace: enzymatic_reaction def: "1 acetyl-CoA + 1 putrescine => 1 CoA + 1 N-acetylputrescine." [] xref: EC:2.3.1.57 xref: GO:0004145 "molecular_function:diamine N-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_input_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC02714 ! N-acetylputrescine relationship: has_output_compound UPa:UPC02714 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetylputrescine relationship: part_of UPa:ULS00163 ! N-acetylputrescine from putrescine relationship: part_of UPa:ULS00163 {cardinality="1", order="1"} ! N-acetylputrescine from putrescine [Term] id: UPa:UER00364 name: carbamoyl phosphate from L-arginine: step 1/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-arginine => 1 L-citrulline + 1 NH(3)." [] xref: EC:3.5.3.6 xref: GO:0016990 "molecular_function:arginine deiminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00327 ! L-citrulline relationship: has_output_compound UPa:UPC00327 {cardinality="1", is_alternate="False", is_primary="True"} ! L-citrulline relationship: part_of UPa:ULS00164 ! carbamoyl phosphate from L-arginine relationship: part_of UPa:ULS00164 {cardinality="1", order="1"} ! carbamoyl phosphate from L-arginine [Term] id: UPa:UER00365 name: carbamoyl phosphate from L-arginine: step 2/2 namespace: enzymatic_reaction def: "1 L-citrulline + 1 phosphate => 1 L-ornithine + 1 carbamoyl phosphate." [] xref: EC:2.1.3.3 xref: GO:0004585 "molecular_function:ornithine carbamoyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00327 ! L-citrulline relationship: has_input_compound UPa:UPC00327 {cardinality="1", is_alternate="False", is_primary="True"} ! L-citrulline relationship: has_output_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="False"} ! L-ornithine relationship: has_output_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="True"} ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00169 ! carbamoyl phosphate relationship: part_of UPa:ULS00164 ! carbamoyl phosphate from L-arginine relationship: part_of UPa:ULS00164 {cardinality="1", order="2"} ! carbamoyl phosphate from L-arginine [Term] id: UPa:UER00366 name: CO(2) and NH(3) from carbamoyl phosphate: step 1/1 namespace: enzymatic_reaction def: "1 ADP + 1 carbamoyl phosphate => 1 ATP + 1 CO(2) + 1 NH(3)." [] xref: EC:2.7.2.2 xref: GO:0008804 "molecular_function:carbamate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00008 ! ADP relationship: has_input_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_input_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="True"} ! carbamoyl phosphate relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00002 ! ATP relationship: has_output_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="True"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="True"} ! NH(3) relationship: part_of UPa:ULS00467 {cardinality="1", order="1"} ! CO(2) and NH(3) from carbamoyl phosphate relationship: part_of UPa:ULS00467 ! CO(2) and NH(3) from carbamoyl phosphate [Term] id: UPa:UER00367 name: (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1 namespace: enzymatic_reaction def: "1 (R)-mevalonate + 1 CoA + 2 NAD(+) => 1 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH." [] xref: EC:1.1.1.88 xref: GO:0042282 "molecular_function:hydroxymethylglutaryl-CoA reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00418 ! (R)-mevalonate relationship: has_input_compound UPa:UPC00418 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-mevalonate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00356 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: part_of UPa:ULS00165 ! (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate relationship: part_of UPa:ULS00165 {cardinality="1", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate [Term] id: UPa:UER00368 name: geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 dimethylallyl diphosphate + 1 isopentenyl diphosphate => 1 diphosphate + 1 geranyl diphosphate." [] xref: EC:2.5.1.1 xref: GO:0004161 "molecular_function:dimethylallyltranstransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00129 {cardinality="1", is_alternate="False", is_primary="True"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00235 {cardinality="1", is_alternate="False", is_primary="True"} ! dimethylallyl diphosphate relationship: has_input_compound UPa:UPC00235 ! dimethylallyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00341 {cardinality="1", is_alternate="False", is_primary="True"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00341 ! geranyl diphosphate relationship: part_of UPa:ULS00166 ! geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate relationship: part_of UPa:ULS00166 {cardinality="1", order="1"} ! geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate [Term] id: UPa:UER00369 name: farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 geranyl diphosphate + 1 isopentenyl diphosphate => 1 diphosphate + 1 farnesyl diphosphate." [] xref: EC:2.5.1.10 xref: GO:0004337 "molecular_function:geranyltranstransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00129 {cardinality="1", is_alternate="False", is_primary="True"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 {cardinality="1", is_alternate="False", is_primary="True"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00448 {cardinality="1", is_alternate="False", is_primary="True"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00448 ! farnesyl diphosphate relationship: part_of UPa:ULS00167 {cardinality="1", order="1"} ! farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate relationship: part_of UPa:ULS00167 ! farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate [Term] id: UPa:UER00370 name: CO(2) and NH(3) from urea (urease route): step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 urea => 1 CO(2) + 2 NH(3)." [] xref: EC:3.5.1.5 xref: GO:0009039 "molecular_function:urease activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00086 ! urea relationship: has_input_compound UPa:UPC00086 {cardinality="1", is_alternate="False", is_primary="True"} ! urea relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="True"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="True"} ! NH(3) relationship: part_of UPa:ULS00168 {cardinality="1", order="1"} ! CO(2) and NH(3) from urea (urease route) relationship: part_of UPa:ULS00168 ! CO(2) and NH(3) from urea (urease route) [Term] id: UPa:UER00371 name: CO(2) and NH(3) from urea (allophanate route): step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 bicarbonate + 1 urea => 1 ADP + 1 phosphate + 1 urea-1-carboxylate." [] xref: EC:6.3.4.6 xref: GO:0004847 "molecular_function:urea carboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00086 {cardinality="1", is_alternate="False", is_primary="True"} ! urea relationship: has_input_compound UPa:UPC00086 ! urea relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_input_compound UPa:UPC00288 {cardinality="1", is_alternate="False", is_primary="False"} ! bicarbonate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC01010 {cardinality="1", is_alternate="False", is_primary="True"} ! urea-1-carboxylate relationship: has_output_compound UPa:UPC01010 ! urea-1-carboxylate relationship: part_of UPa:ULS00169 {cardinality="1", order="1"} ! CO(2) and NH(3) from urea (allophanate route) relationship: part_of UPa:ULS00169 ! CO(2) and NH(3) from urea (allophanate route) [Term] id: UPa:UER00372 name: CO(2) and NH(3) from urea (allophanate route): step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 urea-1-carboxylate => 2 CO(2) + 2 NH(3)." [] xref: EC:3.5.1.54 xref: GO:0004039 "molecular_function:allophanate hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01010 {cardinality="1", is_alternate="False", is_primary="True"} ! urea-1-carboxylate relationship: has_input_compound UPa:UPC01010 ! urea-1-carboxylate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="True"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="True"} ! NH(3) relationship: part_of UPa:ULS00169 {cardinality="1", order="2"} ! CO(2) and NH(3) from urea (allophanate route) relationship: part_of UPa:ULS00169 ! CO(2) and NH(3) from urea (allophanate route) [Term] id: UPa:UER00373 name: L-glutamate from L-proline: step 1/2 namespace: enzymatic_reaction def: "1 L-proline + 1 Quinone => 1 (S)-1-pyrroline-5-carboxylic acid + 1 Hydroquinone." [] xref: EC:1.5.5.2 xref: GO:0004657 "molecular_function:proline dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00148 {cardinality="1", is_alternate="False", is_primary="True"} ! L-proline relationship: has_input_compound UPa:UPC00148 ! L-proline relationship: has_input_compound UPa:UPC15602 ! Quinone relationship: has_input_compound UPa:UPC15602 {cardinality="1", is_alternate="False", is_primary="False"} ! Quinone relationship: has_output_compound UPa:UPC03912 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-1-pyrroline-5-carboxylic acid relationship: has_output_compound UPa:UPC03912 ! (S)-1-pyrroline-5-carboxylic acid relationship: has_output_compound UPa:UPC15603 ! Hydroquinone relationship: has_output_compound UPa:UPC15603 {cardinality="1", is_alternate="False", is_primary="False"} ! Hydroquinone relationship: part_of UPa:ULS00170 {cardinality="1", order="1"} ! L-glutamate from L-proline relationship: part_of UPa:ULS00170 ! L-glutamate from L-proline [Term] id: UPa:UER00374 name: L-glutamate from L-proline: step 2/2 namespace: enzymatic_reaction def: "1 (S)-1-pyrroline-5-carboxylic acid + 2 H(2)O + 1 NAD(+) => 1 H(+) + 1 L-glutamate + 1 NADH." [] xref: EC:1.2.1.88 xref: GO:0003842 "molecular_function:1-pyrroline-5-carboxylate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC03912 ! (S)-1-pyrroline-5-carboxylic acid relationship: has_input_compound UPa:UPC03912 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-1-pyrroline-5-carboxylic acid relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:ULS00170 {cardinality="1", order="2"} ! L-glutamate from L-proline relationship: part_of UPa:ULS00170 ! L-glutamate from L-proline [Term] id: UPa:UER00375 name: 5-aminolevulinate from glycine: step 1/1 namespace: enzymatic_reaction def: "1 glycine + 1 succinyl-CoA => 1 5-aminolevulinate + 1 CO(2) + 1 CoA." [] xref: EC:2.3.1.37 xref: GO:0003870 "molecular_function:5-aminolevulinate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="True"} ! glycine relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="False"} ! succinyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00430 ! 5-aminolevulinate relationship: has_output_compound UPa:UPC00430 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-aminolevulinate relationship: part_of UPa:ULS00171 {cardinality="1", order="1"} ! 5-aminolevulinate from glycine relationship: part_of UPa:ULS00171 ! 5-aminolevulinate from glycine [Term] id: UPa:UER00376 name: siroheme from sirohydrochlorin: step 1/1 namespace: enzymatic_reaction def: "1 Fe2+ + 1 sirohydrochlorin => 2 H(+) + 1 siroheme." [] xref: EC:4.99.1.4 xref: GO:0051266 "molecular_function:sirohydrochlorin ferrochelatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC05778 {cardinality="1", is_alternate="False", is_primary="True"} ! sirohydrochlorin relationship: has_input_compound UPa:UPC05778 ! sirohydrochlorin relationship: has_input_compound UPa:UPC14818 {cardinality="1", is_alternate="False", is_primary="False"} ! Fe2+ relationship: has_input_compound UPa:UPC14818 ! Fe2+ relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00748 {cardinality="1", is_alternate="False", is_primary="True"} ! siroheme relationship: has_output_compound UPa:UPC00748 ! siroheme relationship: part_of UPa:ULS00174 {cardinality="1", order="1"} ! siroheme from sirohydrochlorin relationship: part_of UPa:ULS00174 ! siroheme from sirohydrochlorin [Term] id: UPa:UER00377 name: D-xylulose 5-phosphate from L-ascorbate: step 1/4 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-ascorbate + 1 protein N(pi)-phospho-L-histidine => 1 3-dehydro-L-gulonate 6-phosphate + 1 protein-L-histidine." [] xref: EC:3.1.1 xref: GO:0004620 "molecular_function:phospholipase activity" xref: GO:0010296 "molecular_function:prenylcysteine methylesterase activity" xref: GO:0016298 "molecular_function:lipase activity" xref: GO:0018731 "molecular_function:1-oxa-2-oxocycloheptane lactonase activity" xref: GO:0018732 "molecular_function:sulfolactone hydrolase activity" xref: GO:0018733 "molecular_function:3,4-dihydrocoumarin hydrolase activity" xref: GO:0018734 "molecular_function:butyrolactone hydrolase activity" xref: GO:0034892 "molecular_function:endosulfan lactone lactonase activity" xref: GO:0035460 "molecular_function:L-ascorbate 6-phosphate lactonase activity" xref: GO:0043905 "molecular_function:Ser-tRNA(Thr) hydrolase activity" xref: GO:0043906 "molecular_function:Ala-tRNA(Pro) hydrolase activity" xref: GO:0043907 "molecular_function:Cys-tRNA(Pro) hydrolase activity" xref: GO:0043908 "molecular_function:Ser(Gly)-tRNA(Ala) hydrolase activity" xref: GO:0047376 "molecular_function:all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity" xref: GO:0050253 "molecular_function:retinyl-palmitate esterase activity" xref: GO:0052689 "molecular_function:carboxylic ester hydrolase activity" xref: GO:0052767 "molecular_function:mannosyl-oligosaccharide 1,6-alpha-mannosidase activity" xref: GO:0052768 "molecular_function:mannosyl-oligosaccharide 1,3-alpha-mannosidase activity" xref: GO:0080030 "molecular_function:methyl indole-3-acetate esterase activity" xref: GO:0080031 "molecular_function:methyl salicylate esterase activity" xref: GO:0080032 "molecular_function:methyl jasmonate esterase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00072 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ascorbate relationship: has_input_compound UPa:UPC00072 ! L-ascorbate relationship: has_input_compound UPa:UPC04261 {cardinality="1", is_alternate="False", is_primary="False"} ! protein N(pi)-phospho-L-histidine relationship: has_input_compound UPa:UPC04261 ! protein N(pi)-phospho-L-histidine relationship: has_output_compound UPa:UPC00615 ! protein-L-histidine relationship: has_output_compound UPa:UPC00615 {cardinality="1", is_alternate="False", is_primary="False"} ! protein-L-histidine relationship: has_output_compound UPa:UPC14899 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydro-L-gulonate 6-phosphate relationship: has_output_compound UPa:UPC14899 ! 3-dehydro-L-gulonate 6-phosphate relationship: part_of UPa:ULS00176 {cardinality="1", order="1"} ! D-xylulose 5-phosphate from L-ascorbate relationship: part_of UPa:ULS00176 ! D-xylulose 5-phosphate from L-ascorbate [Term] id: UPa:UER00378 name: D-xylulose 5-phosphate from L-ascorbate: step 2/4 namespace: enzymatic_reaction def: "1 3-dehydro-L-gulonate 6-phosphate + 1 H(+) => 1 CO(2) + 1 L-xylulose 5-phosphate." [] xref: EC:4.1.1.85 xref: GO:0033982 "molecular_function:3-dehydro-L-gulonate-6-phosphate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC14899 ! 3-dehydro-L-gulonate 6-phosphate relationship: has_input_compound UPa:UPC14899 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydro-L-gulonate 6-phosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC03291 {cardinality="1", is_alternate="False", is_primary="True"} ! L-xylulose 5-phosphate relationship: has_output_compound UPa:UPC03291 ! L-xylulose 5-phosphate relationship: part_of UPa:ULS00176 {cardinality="1", order="2"} ! D-xylulose 5-phosphate from L-ascorbate relationship: part_of UPa:ULS00176 ! D-xylulose 5-phosphate from L-ascorbate [Term] id: UPa:UER00379 name: D-xylulose 5-phosphate from L-ascorbate: step 3/4 namespace: enzymatic_reaction def: "1 L-xylulose 5-phosphate => 1 L-ribulose 5-phosphate." [] xref: EC:5.1.3.22 xref: GO:0034015 "molecular_function:L-ribulose-5-phosphate 3-epimerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03291 ! L-xylulose 5-phosphate relationship: has_input_compound UPa:UPC03291 {cardinality="1", is_alternate="False", is_primary="True"} ! L-xylulose 5-phosphate relationship: has_output_compound UPa:UPC01101 ! L-ribulose 5-phosphate relationship: has_output_compound UPa:UPC01101 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ribulose 5-phosphate relationship: part_of UPa:ULS00176 {cardinality="1", order="3"} ! D-xylulose 5-phosphate from L-ascorbate relationship: part_of UPa:ULS00176 ! D-xylulose 5-phosphate from L-ascorbate [Term] id: UPa:UER00380 name: D-xylulose 5-phosphate from L-ascorbate: step 4/4 namespace: enzymatic_reaction def: "1 L-ribulose 5-phosphate => 1 D-xylulose 5-phosphate." [] xref: EC:5.1.3.4 xref: GO:0008742 "molecular_function:L-ribulose-phosphate 4-epimerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01101 ! L-ribulose 5-phosphate relationship: has_input_compound UPa:UPC01101 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00231 {cardinality="1", is_alternate="False", is_primary="True"} ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: part_of UPa:ULS00176 ! D-xylulose 5-phosphate from L-ascorbate relationship: part_of UPa:ULS00176 {cardinality="1", order="4"} ! D-xylulose 5-phosphate from L-ascorbate [Term] id: UPa:UER00381 name: betaine from glycine: step 1/3 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 glycine => 1 S-adenosyl-L-homocysteine + 1 sarcosine." [] xref: EC:2.1.1.156 xref: GO:0017174 "molecular_function:glycine N-methyltransferase activity" xref: GO:0052730 "molecular_function:sarcosine N-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="True"} ! glycine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00213 {cardinality="1", is_alternate="False", is_primary="True"} ! sarcosine relationship: has_output_compound UPa:UPC00213 ! sarcosine relationship: part_of UPa:ULS00104 ! betaine from glycine relationship: part_of UPa:ULS00104 {cardinality="1", order="1"} ! betaine from glycine [Term] id: UPa:UER00382 name: betaine from glycine: step 2/3 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 sarcosine => 1 N,N-dimethylglycine + 1 S-adenosyl-L-homocysteine." [] xref: EC:2.1.1.156 xref: EC:2.1.1.157 xref: GO:0017174 "molecular_function:glycine N-methyltransferase activity" xref: GO:0052729 "molecular_function:dimethylglycine N-methyltransferase activity" xref: GO:0052730 "molecular_function:sarcosine N-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00213 ! sarcosine relationship: has_input_compound UPa:UPC00213 {cardinality="1", is_alternate="False", is_primary="True"} ! sarcosine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC01026 {cardinality="1", is_alternate="False", is_primary="True"} ! N,N-dimethylglycine relationship: has_output_compound UPa:UPC01026 ! N,N-dimethylglycine relationship: part_of UPa:ULS00104 ! betaine from glycine relationship: part_of UPa:ULS00104 {cardinality="1", order="2"} ! betaine from glycine [Term] id: UPa:UER00383 name: betaine from glycine: step 3/3 namespace: enzymatic_reaction def: "1 N,N-dimethylglycine + 1 S-adenosyl-L-methionine => 1 S-adenosyl-L-homocysteine + 1 betaine." [] xref: EC:2.1.1.157 xref: GO:0052729 "molecular_function:dimethylglycine N-methyltransferase activity" xref: GO:0052730 "molecular_function:sarcosine N-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01026 {cardinality="1", is_alternate="False", is_primary="True"} ! N,N-dimethylglycine relationship: has_input_compound UPa:UPC01026 ! N,N-dimethylglycine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00719 ! betaine relationship: has_output_compound UPa:UPC00719 {cardinality="1", is_alternate="False", is_primary="True"} ! betaine relationship: part_of UPa:ULS00104 ! betaine from glycine relationship: part_of UPa:ULS00104 {cardinality="1", order="3"} ! betaine from glycine [Term] id: UPa:UER00384 name: betaine from choline: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 O(2) + 1 choline => 1 H(2)O(2) + 1 betaine." [] xref: EC:1.1.3.17 xref: GO:0033713 "molecular_function:choline:oxygen 1-oxidoreductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_input_compound UPa:UPC00114 {cardinality="1", is_alternate="False", is_primary="True"} ! choline relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00719 ! betaine relationship: has_output_compound UPa:UPC00719 {cardinality="1", is_alternate="False", is_primary="True"} ! betaine relationship: part_of UPa:ULS00181 ! betaine from choline relationship: part_of UPa:ULS00181 {cardinality="1", order="1"} ! betaine from choline [Term] id: UPa:UER00385 name: betaine aldehyde from choline (cytochrome c reductase route): step 1/1 namespace: enzymatic_reaction def: "1 acceptor + 1 choline => 1 betaine aldehyde + 1 reduced acceptor." [] xref: EC:1.1.99.1 xref: GO:0008812 "molecular_function:choline dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_input_compound UPa:UPC00114 {cardinality="1", is_alternate="False", is_primary="True"} ! choline relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde relationship: has_output_compound UPa:UPC00576 {cardinality="1", is_alternate="False", is_primary="True"} ! betaine aldehyde relationship: part_of UPa:ULS00182 ! betaine aldehyde from choline (cytochrome c reductase route) relationship: part_of UPa:ULS00182 {cardinality="1", order="1"} ! betaine aldehyde from choline (cytochrome c reductase route) [Term] id: UPa:UER00386 name: betaine from betaine aldehyde: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 betaine aldehyde => 2 H(+) + 1 NADH + 1 betaine." [] xref: EC:1.2.1.8 xref: GO:0008802 "molecular_function:betaine-aldehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00576 ! betaine aldehyde relationship: has_input_compound UPa:UPC00576 {cardinality="1", is_alternate="False", is_primary="True"} ! betaine aldehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00719 ! betaine relationship: has_output_compound UPa:UPC00719 {cardinality="1", is_alternate="False", is_primary="True"} ! betaine relationship: part_of UPa:ULS00183 ! betaine from betaine aldehyde relationship: part_of UPa:ULS00183 {cardinality="1", order="1"} ! betaine from betaine aldehyde [Term] id: UPa:UER00387 name: glycolate from 1,2-dichloroethane: step 1/4 namespace: enzymatic_reaction def: "1 1,2-dichloroethane + 1 H(2)O => 1 2-chloroethanol + 1 HCl." [] xref: EC:3.8.1.5 xref: GO:0018786 "molecular_function:haloalkane dehalogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC06752 {cardinality="1", is_alternate="False", is_primary="True"} ! 1,2-dichloroethane relationship: has_input_compound UPa:UPC06752 ! 1,2-dichloroethane relationship: has_output_compound UPa:UPC01327 ! HCl relationship: has_output_compound UPa:UPC01327 {cardinality="1", is_alternate="False", is_primary="False"} ! HCl relationship: has_output_compound UPa:UPC06753 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-chloroethanol relationship: has_output_compound UPa:UPC06753 ! 2-chloroethanol relationship: part_of UPa:ULS00184 ! glycolate from 1,2-dichloroethane relationship: part_of UPa:ULS00184 {cardinality="1", order="1"} ! glycolate from 1,2-dichloroethane [Term] id: UPa:UER00388 name: glycolate from 1,2-dichloroethane: step 2/4 namespace: enzymatic_reaction def: "1 2-chloroethanol + 2 ferricytochrome c => 2 H(+) + 1 chloroacetaldehyde + 2 ferrocytochrome c." [] xref: EC:1.1.2.8 xref: GO:0052934 "molecular_function:alcohol dehydrogenase (cytochrome c) activity" xref: GO:0052935 "molecular_function:ethanol:cytochrome c oxidoreductase activity" xref: GO:0052936 "molecular_function:2-chloroethanol:cytochrome c oxidoreductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00125 ! ferricytochrome c relationship: has_input_compound UPa:UPC00125 {cardinality="1", is_alternate="False", is_primary="False"} ! ferricytochrome c relationship: has_input_compound UPa:UPC06753 ! 2-chloroethanol relationship: has_input_compound UPa:UPC06753 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-chloroethanol relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00126 ! ferrocytochrome c relationship: has_output_compound UPa:UPC00126 {cardinality="1", is_alternate="False", is_primary="False"} ! ferrocytochrome c relationship: has_output_compound UPa:UPC06754 {cardinality="1", is_alternate="False", is_primary="True"} ! chloroacetaldehyde relationship: has_output_compound UPa:UPC06754 ! chloroacetaldehyde relationship: part_of UPa:ULS00184 ! glycolate from 1,2-dichloroethane relationship: part_of UPa:ULS00184 {cardinality="1", order="2"} ! glycolate from 1,2-dichloroethane [Term] id: UPa:UER00389 name: glycolate from 1,2-dichloroethane: step 3/4 namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 chloroacetaldehyde => 1 H(+) + 1 NADH + 1 chloroacetic acid." [] xref: EC:1.2.1.3 xref: GO:0004029 "molecular_function:aldehyde dehydrogenase (NAD) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC06754 ! chloroacetaldehyde relationship: has_input_compound UPa:UPC06754 {cardinality="1", is_alternate="False", is_primary="True"} ! chloroacetaldehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC06755 {cardinality="1", is_alternate="False", is_primary="True"} ! chloroacetic acid relationship: has_output_compound UPa:UPC06755 ! chloroacetic acid relationship: part_of UPa:ULS00184 ! glycolate from 1,2-dichloroethane relationship: part_of UPa:ULS00184 {cardinality="1", order="3"} ! glycolate from 1,2-dichloroethane [Term] id: UPa:UER00390 name: glycolate from 1,2-dichloroethane: step 4/4 namespace: enzymatic_reaction def: "1 H(2)O + 1 chloroacetic acid => 1 HCl + 1 glycolate." [] xref: EC:3.8.1.3 xref: GO:0018785 "molecular_function:haloacetate dehalogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC06755 {cardinality="1", is_alternate="False", is_primary="True"} ! chloroacetic acid relationship: has_input_compound UPa:UPC06755 ! chloroacetic acid relationship: has_output_compound UPa:UPC00160 {cardinality="1", is_alternate="False", is_primary="True"} ! glycolate relationship: has_output_compound UPa:UPC00160 ! glycolate relationship: has_output_compound UPa:UPC01327 {cardinality="1", is_alternate="False", is_primary="False"} ! HCl relationship: has_output_compound UPa:UPC01327 ! HCl relationship: part_of UPa:ULS00184 {cardinality="1", order="4"} ! glycolate from 1,2-dichloroethane relationship: part_of UPa:ULS00184 ! glycolate from 1,2-dichloroethane [Term] id: UPa:UER00391 name: catechol from benzene: step 1/2 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 benzene => 1 NAD(+) + 1 cis-1,2-dihydrobenzene-1,2-diol." [] xref: EC:1.14.12.3 xref: GO:0018619 "molecular_function:benzene 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC01407 {cardinality="1", is_alternate="False", is_primary="True"} ! benzene relationship: has_input_compound UPa:UPC01407 ! benzene relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC04091 {cardinality="1", is_alternate="False", is_primary="True"} ! cis-1,2-dihydrobenzene-1,2-diol relationship: has_output_compound UPa:UPC04091 ! cis-1,2-dihydrobenzene-1,2-diol relationship: part_of UPa:ULS00185 {cardinality="1", order="1"} ! catechol from benzene relationship: part_of UPa:ULS00185 ! catechol from benzene [Term] id: UPa:UER00392 name: catechol from benzene: step 2/2 namespace: enzymatic_reaction def: "1 NAD(+) + 1 cis-1,2-dihydrobenzene-1,2-diol => 1 H(+) + 1 NADH + 1 catechol." [] xref: EC:1.3.1.19 xref: GO:0018504 "molecular_function:cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC04091 ! cis-1,2-dihydrobenzene-1,2-diol relationship: has_input_compound UPa:UPC04091 {cardinality="1", is_alternate="False", is_primary="True"} ! cis-1,2-dihydrobenzene-1,2-diol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00090 {cardinality="1", is_alternate="False", is_primary="True"} ! catechol relationship: has_output_compound UPa:UPC00090 ! catechol relationship: part_of UPa:ULS00185 {cardinality="1", order="2"} ! catechol from benzene relationship: part_of UPa:ULS00185 ! catechol from benzene [Term] id: UPa:UER00393 name: 3-methylcatechol from toluene: step 1/2 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 toluene => 1 (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + 1 NAD(+)." [] xref: EC:1.14.12.11 xref: GO:0018624 "molecular_function:toluene dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC01455 ! toluene relationship: has_input_compound UPa:UPC01455 {cardinality="1", is_alternate="False", is_primary="True"} ! toluene relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC04592 ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol relationship: has_output_compound UPa:UPC04592 {cardinality="1", is_alternate="False", is_primary="True"} ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol relationship: part_of UPa:ULS00186 {cardinality="1", order="1"} ! 3-methylcatechol from toluene relationship: part_of UPa:ULS00186 ! 3-methylcatechol from toluene [Term] id: UPa:UER00394 name: 3-methylcatechol from toluene: step 2/2 namespace: enzymatic_reaction def: "1 (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + 1 NAD(+) => 1 3-methylcatechol + 1 H(+) + 1 NADH." [] xref: EC:1.3.1.19 xref: GO:0018504 "molecular_function:cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC04592 {cardinality="1", is_alternate="False", is_primary="True"} ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol relationship: has_input_compound UPa:UPC04592 ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC02923 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methylcatechol relationship: has_output_compound UPa:UPC02923 ! 3-methylcatechol relationship: part_of UPa:ULS00186 {cardinality="1", order="2"} ! 3-methylcatechol from toluene relationship: part_of UPa:ULS00186 ! 3-methylcatechol from toluene [Term] id: UPa:UER00395 name: sarcosine from creatinine: step 1/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 creatinine => 1 N-methylhydantoin + 1 NH(3)." [] xref: EC:3.5.4.21 xref: GO:0047790 "molecular_function:creatinine deaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00791 ! creatinine relationship: has_input_compound UPa:UPC00791 {cardinality="1", is_alternate="False", is_primary="True"} ! creatinine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC02565 {cardinality="1", is_alternate="False", is_primary="True"} ! N-methylhydantoin relationship: has_output_compound UPa:UPC02565 ! N-methylhydantoin relationship: part_of UPa:ULS00187 {cardinality="1", order="1"} ! sarcosine from creatinine relationship: part_of UPa:ULS00187 ! sarcosine from creatinine [Term] id: UPa:UER00396 name: sarcosine from creatinine: step 2/3 namespace: enzymatic_reaction def: "1 ATP + 2 H(2)O + 1 N-methylhydantoin => 1 ADP + 1 N-carbamoylsarcosine + 1 phosphate." [] xref: EC:3.5.2.14 xref: GO:0047423 "molecular_function:N-methylhydantoinase (ATP-hydrolyzing) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC02565 {cardinality="1", is_alternate="False", is_primary="True"} ! N-methylhydantoin relationship: has_input_compound UPa:UPC02565 ! N-methylhydantoin relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC01043 {cardinality="1", is_alternate="False", is_primary="True"} ! N-carbamoylsarcosine relationship: has_output_compound UPa:UPC01043 ! N-carbamoylsarcosine relationship: part_of UPa:ULS00187 {cardinality="1", order="2"} ! sarcosine from creatinine relationship: part_of UPa:ULS00187 ! sarcosine from creatinine [Term] id: UPa:UER00397 name: sarcosine from creatinine: step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-carbamoylsarcosine => 1 CO(2) + 1 NH(3) + 1 sarcosine." [] xref: EC:3.5.1.59 xref: GO:0050127 "molecular_function:N-carbamoylsarcosine amidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC01043 {cardinality="1", is_alternate="False", is_primary="True"} ! N-carbamoylsarcosine relationship: has_input_compound UPa:UPC01043 ! N-carbamoylsarcosine relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00213 ! sarcosine relationship: has_output_compound UPa:UPC00213 {cardinality="1", is_alternate="False", is_primary="True"} ! sarcosine relationship: part_of UPa:ULS00187 {cardinality="1", order="3"} ! sarcosine from creatinine relationship: part_of UPa:ULS00187 ! sarcosine from creatinine [Term] id: UPa:UER00398 name: formaldehyde and glycine from sarcosine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 electron-transferring flavoprotein + 1 sarcosine => 1 formaldehyde + 1 glycine + 1 reduced electron-transferring flavoprotein." [] xref: EC:1.5.8.3 xref: GO:0008480 "molecular_function:sarcosine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00213 ! sarcosine relationship: has_input_compound UPa:UPC00213 {cardinality="1", is_alternate="False", is_primary="True"} ! sarcosine relationship: has_input_compound UPa:UPC04253 {cardinality="1", is_alternate="False", is_primary="False"} ! electron-transferring flavoprotein relationship: has_input_compound UPa:UPC04253 ! electron-transferring flavoprotein relationship: has_output_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="True"} ! glycine relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00067 {cardinality="1", is_alternate="False", is_primary="True"} ! formaldehyde relationship: has_output_compound UPa:UPC00067 ! formaldehyde relationship: has_output_compound UPa:UPC04570 ! reduced electron-transferring flavoprotein relationship: has_output_compound UPa:UPC04570 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced electron-transferring flavoprotein relationship: part_of UPa:ULS00206 ! formaldehyde and glycine from sarcosine relationship: part_of UPa:ULS00206 {cardinality="1", order="1"} ! formaldehyde and glycine from sarcosine [Term] id: UPa:UER00399 name: 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 D-ribulose 5-phosphate => 1 2-hydroxy-3-oxobutyl phosphate + 1 formate." [] xref: EC:4.1.99.12 xref: GO:0008686 "molecular_function:3,4-dihydroxy-2-butanone-4-phosphate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00199 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC15556 ! 2-hydroxy-3-oxobutyl phosphate relationship: has_output_compound UPa:UPC15556 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxobutyl phosphate relationship: part_of UPa:ULS00188 {cardinality="1", order="1"} ! 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate relationship: part_of UPa:ULS00188 ! 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate [Term] id: UPa:UER00400 name: 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4 namespace: enzymatic_reaction def: "1 GTP + 3 H(2)O => 1 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine + 1 diphosphate + 1 formate." [] xref: EC:3.5.4.25 xref: GO:0003935 "molecular_function:GTP cyclohydrolase II activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00044 {cardinality="1", is_alternate="False", is_primary="True"} ! GTP relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_output_compound UPa:UPC01304 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine relationship: has_output_compound UPa:UPC01304 ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine relationship: part_of UPa:ULS00189 {cardinality="1", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP relationship: part_of UPa:ULS00189 ! 5-amino-6-(D-ribitylamino)uracil from GTP [Term] id: UPa:UER00401 name: 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4 namespace: enzymatic_reaction def: "1 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine + 1 H(2)O => 1 5-amino-6-(5-phosphoribosylamino)uracil + 1 NH(3)." [] xref: EC:3.5.4.26 xref: GO:0008835 "molecular_function:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01304 ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine relationship: has_input_compound UPa:UPC01304 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC01268 ! 5-amino-6-(5-phosphoribosylamino)uracil relationship: has_output_compound UPa:UPC01268 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-6-(5-phosphoribosylamino)uracil relationship: part_of UPa:ULS00189 {cardinality="1", order="2"} ! 5-amino-6-(D-ribitylamino)uracil from GTP relationship: part_of UPa:ULS00189 ! 5-amino-6-(D-ribitylamino)uracil from GTP [Term] id: UPa:UER00402 name: 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4 namespace: enzymatic_reaction def: "1 5-amino-6-(5-phosphoribosylamino)uracil + 1 H(+) + 1 NADPH => 1 5-amino-6-(5-phosphoribitylamino)uracil + 1 NADP(+)." [] xref: EC:1.1.1.193 xref: GO:0008703 "molecular_function:5-amino-6-(5-phosphoribosylamino)uracil reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC01268 ! 5-amino-6-(5-phosphoribosylamino)uracil relationship: has_input_compound UPa:UPC01268 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-6-(5-phosphoribosylamino)uracil relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC04454 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-6-(5-phosphoribitylamino)uracil relationship: has_output_compound UPa:UPC04454 ! 5-amino-6-(5-phosphoribitylamino)uracil relationship: part_of UPa:ULS00189 {cardinality="1", order="3"} ! 5-amino-6-(D-ribitylamino)uracil from GTP relationship: part_of UPa:ULS00189 ! 5-amino-6-(D-ribitylamino)uracil from GTP [Term] id: UPa:UER00403 name: 5-amino-6-(D-ribitylamino)uracil from GTP: step 4/4 namespace: enzymatic_reaction def: "1 5-amino-6-(5-phosphoribitylamino)uracil + 1 H(2)O => 1 5-amino-6-(D-ribitylamino)uracil + 1 phosphate." [] xref: EC:3.1.3 xref: GO:0008138 "molecular_function:protein tyrosine/serine/threonine phosphatase activity" xref: GO:0008330 "molecular_function:protein tyrosine/threonine phosphatase activity" xref: GO:0008579 "molecular_function:JUN kinase phosphatase activity" xref: GO:0008969 "molecular_function:phosphohistidine phosphatase activity" xref: GO:0016312 "molecular_function:inositol bisphosphate phosphatase activity" xref: GO:0016791 "molecular_function:phosphatase activity" xref: GO:0017017 "molecular_function:MAP kinase tyrosine/serine/threonine phosphatase activity" xref: GO:0017161 "molecular_function:inositol-1,3,4-trisphosphate 4-phosphatase activity" xref: GO:0019178 "molecular_function:NADP phosphatase activity" xref: GO:0019198 "molecular_function:transmembrane receptor protein phosphatase activity" xref: GO:0030351 "molecular_function:inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity" xref: GO:0030352 "molecular_function:inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity" xref: GO:0030487 "molecular_function:inositol-4,5-bisphosphate 5-phosphatase activity" xref: GO:0043726 "molecular_function:5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity" xref: GO:0043812 "molecular_function:phosphatidylinositol-4-phosphate phosphatase activity" xref: GO:0043813 "molecular_function:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity" xref: GO:0052629 "molecular_function:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity" xref: GO:0052745 "molecular_function:inositol phosphate phosphatase activity" xref: GO:0052825 "molecular_function:inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity" xref: GO:0052828 "molecular_function:inositol-3,4-bisphosphate 4-phosphatase activity" xref: GO:0052829 "molecular_function:inositol-1,3,4-trisphosphate 1-phosphatase activity" xref: GO:0052830 "molecular_function:inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity" xref: GO:0052831 "molecular_function:inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity" xref: GO:0052867 "molecular_function:phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity" xref: GO:1990003 "molecular_function:IDP phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC04454 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-6-(5-phosphoribitylamino)uracil relationship: has_input_compound UPa:UPC04454 ! 5-amino-6-(5-phosphoribitylamino)uracil relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC04732 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-6-(D-ribitylamino)uracil relationship: has_output_compound UPa:UPC04732 ! 5-amino-6-(D-ribitylamino)uracil relationship: part_of UPa:ULS00189 {cardinality="1", order="4"} ! 5-amino-6-(D-ribitylamino)uracil from GTP relationship: part_of UPa:ULS00189 ! 5-amino-6-(D-ribitylamino)uracil from GTP [Term] id: UPa:UER00404 name: riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2 namespace: enzymatic_reaction def: "1 2-hydroxy-3-oxobutyl phosphate + 1 5-amino-6-(D-ribitylamino)uracil => 1 6,7-dimethyl-8-(1-D-ribityl)lumazine + 2 H(2)O + 1 phosphate." [] xref: EC:2.5.1.78 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04732 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-6-(D-ribitylamino)uracil relationship: has_input_compound UPa:UPC04732 ! 5-amino-6-(D-ribitylamino)uracil relationship: has_input_compound UPa:UPC15556 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxobutyl phosphate relationship: has_input_compound UPa:UPC15556 ! 2-hydroxy-3-oxobutyl phosphate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC04332 ! 6,7-dimethyl-8-(1-D-ribityl)lumazine relationship: has_output_compound UPa:UPC04332 {cardinality="1", is_alternate="False", is_primary="True"} ! 6,7-dimethyl-8-(1-D-ribityl)lumazine relationship: part_of UPa:ULS00499 ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil relationship: part_of UPa:ULS00499 {cardinality="1", order="1"} ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil [Term] id: UPa:UER00405 name: riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2 namespace: enzymatic_reaction def: "2 6,7-dimethyl-8-(1-D-ribityl)lumazine => 1 5-amino-6-(D-ribitylamino)uracil + 1 riboflavin." [] xref: EC:2.5.1.9 xref: GO:0004746 "molecular_function:riboflavin synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04332 {cardinality="1", is_alternate="False", is_primary="True"} ! 6,7-dimethyl-8-(1-D-ribityl)lumazine relationship: has_input_compound UPa:UPC04332 ! 6,7-dimethyl-8-(1-D-ribityl)lumazine relationship: has_output_compound UPa:UPC00255 ! riboflavin relationship: has_output_compound UPa:UPC00255 {cardinality="1", is_alternate="False", is_primary="True"} ! riboflavin relationship: has_output_compound UPa:UPC04732 ! 5-amino-6-(D-ribitylamino)uracil relationship: has_output_compound UPa:UPC04732 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-amino-6-(D-ribitylamino)uracil relationship: part_of UPa:ULS00499 ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil relationship: part_of UPa:ULS00499 {cardinality="1", order="2"} ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil [Term] id: UPa:UER00406 name: FMN from riboflavin (ATP route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 riboflavin => 1 ADP + 1 FMN." [] xref: EC:2.7.1.26 xref: GO:0008531 "molecular_function:riboflavin kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00255 ! riboflavin relationship: has_input_compound UPa:UPC00255 {cardinality="1", is_alternate="False", is_primary="True"} ! riboflavin relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00061 {cardinality="1", is_alternate="False", is_primary="True"} ! FMN relationship: has_output_compound UPa:UPC00061 ! FMN relationship: part_of UPa:ULS00192 {cardinality="1", order="1"} ! FMN from riboflavin (ATP route) relationship: part_of UPa:ULS00192 ! FMN from riboflavin (ATP route) [Term] id: UPa:UER00407 name: FAD from FMN: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 FMN => 1 FAD + 1 diphosphate." [] xref: EC:2.7.7.2 xref: GO:0003919 "molecular_function:FMN adenylyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00061 ! FMN relationship: has_input_compound UPa:UPC00061 {cardinality="1", is_alternate="False", is_primary="True"} ! FMN relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00016 ! FAD relationship: has_output_compound UPa:UPC00016 {cardinality="1", is_alternate="False", is_primary="True"} ! FAD relationship: part_of UPa:ULS00193 {cardinality="1", order="1"} ! FAD from FMN relationship: part_of UPa:ULS00193 ! FAD from FMN [Term] id: UPa:UER00408 name: D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3 namespace: enzymatic_reaction def: "1 D-glucose 6-phosphate + 1 NADP(+) => 1 D-glucono-1,5-lactone 6-phosphate + 1 H(+) + 1 NADPH." [] xref: EC:1.1.1.49 xref: GO:0004345 "molecular_function:glucose-6-phosphate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00092 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucose 6-phosphate relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC01236 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucono-1,5-lactone 6-phosphate relationship: has_output_compound UPa:UPC01236 ! D-glucono-1,5-lactone 6-phosphate relationship: part_of UPa:ULS00194 {cardinality="1", order="1"} ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage) relationship: part_of UPa:ULS00194 ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage) [Term] id: UPa:UER00409 name: D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3 namespace: enzymatic_reaction def: "1 D-glucono-1,5-lactone 6-phosphate + 1 H(2)O => 1 6-phospho-D-gluconate." [] xref: EC:3.1.1.31 xref: GO:0017057 "molecular_function:6-phosphogluconolactonase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01236 ! D-glucono-1,5-lactone 6-phosphate relationship: has_input_compound UPa:UPC01236 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucono-1,5-lactone 6-phosphate relationship: has_output_compound UPa:UPC00345 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-phospho-D-gluconate relationship: has_output_compound UPa:UPC00345 ! 6-phospho-D-gluconate relationship: part_of UPa:ULS00194 {cardinality="1", order="2"} ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage) relationship: part_of UPa:ULS00194 ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage) [Term] id: UPa:UER00410 name: D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3 namespace: enzymatic_reaction def: "1 6-phospho-D-gluconate + 1 NADP(+) => 1 CO(2) + 1 D-ribulose 5-phosphate + 1 H(+) + 1 NADPH." [] xref: EC:1.1.1.44 xref: GO:0004616 "molecular_function:phosphogluconate dehydrogenase (decarboxylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00345 ! 6-phospho-D-gluconate relationship: has_input_compound UPa:UPC00345 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-phospho-D-gluconate relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00199 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribulose 5-phosphate relationship: part_of UPa:ULS00194 ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage) relationship: part_of UPa:ULS00194 {cardinality="1", order="3"} ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage) [Term] id: UPa:UER00411 name: D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1 namespace: enzymatic_reaction def: "1 D-ribulose 5-phosphate => 1 D-xylulose 5-phosphate." [] xref: EC:5.1.3.1 xref: GO:0004750 "molecular_function:ribulose-phosphate 3-epimerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00231 {cardinality="1", is_alternate="False", is_primary="True"} ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: part_of UPa:ULS00195 ! D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage) relationship: part_of UPa:ULS00195 {cardinality="1", order="1"} ! D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage) [Term] id: UPa:UER00412 name: D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1 namespace: enzymatic_reaction def: "1 D-ribulose 5-phosphate => 1 D-ribose 5-phosphate." [] xref: EC:5.3.1.6 xref: GO:0004751 "molecular_function:ribose-5-phosphate isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00117 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose 5-phosphate relationship: part_of UPa:ULS00196 ! D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage) relationship: part_of UPa:ULS00196 {cardinality="1", order="1"} ! D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage) [Term] id: UPa:UER00413 name: D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 1/3 namespace: enzymatic_reaction def: "1 D-ribose 5-phosphate + 1 D-xylulose 5-phosphate => 1 D-glyceraldehyde 3-phosphate + 1 sedoheptulose 7-phosphate." [] xref: EC:2.2.1.1 xref: GO:0004802 "molecular_function:transketolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: has_input_compound UPa:UPC00117 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose 5-phosphate relationship: has_input_compound UPa:UPC00231 {cardinality="1", is_alternate="False", is_primary="True"} ! D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC05382 {cardinality="1", is_alternate="False", is_primary="True"} ! sedoheptulose 7-phosphate relationship: has_output_compound UPa:UPC05382 ! sedoheptulose 7-phosphate relationship: part_of UPa:ULS00197 ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage) relationship: part_of UPa:ULS00197 {cardinality="1", order="1"} ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage) [Term] id: UPa:UER00414 name: D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3 namespace: enzymatic_reaction def: "1 D-glyceraldehyde 3-phosphate + 1 sedoheptulose 7-phosphate => 1 D-erythrose 4-phosphate + 1 beta-D-fructose 6-phosphate." [] xref: EC:2.2.1.2 xref: GO:0004801 "molecular_function:sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC05382 {cardinality="1", is_alternate="False", is_primary="True"} ! sedoheptulose 7-phosphate relationship: has_input_compound UPa:UPC05382 ! sedoheptulose 7-phosphate relationship: has_output_compound UPa:UPC00279 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00279 ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC05345 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-D-fructose 6-phosphate relationship: has_output_compound UPa:UPC05345 ! beta-D-fructose 6-phosphate relationship: part_of UPa:ULS00197 ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage) relationship: part_of UPa:ULS00197 {cardinality="1", order="2"} ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage) [Term] id: UPa:UER00415 name: D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 3/3 namespace: enzymatic_reaction def: "1 D-erythrose 4-phosphate + 1 D-xylulose 5-phosphate => 1 D-glyceraldehyde 3-phosphate + 1 beta-D-fructose 6-phosphate." [] xref: EC:2.2.1.1 xref: GO:0004802 "molecular_function:transketolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC00231 {cardinality="1", is_alternate="False", is_primary="True"} ! D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC00279 ! D-erythrose 4-phosphate relationship: has_input_compound UPa:UPC00279 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC05345 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-D-fructose 6-phosphate relationship: has_output_compound UPa:UPC05345 ! beta-D-fructose 6-phosphate relationship: part_of UPa:ULS00197 ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage) relationship: part_of UPa:ULS00197 {cardinality="1", order="3"} ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage) [Term] id: UPa:UER00416 name: pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 1/7 namespace: enzymatic_reaction def: "1 4-hydroxyphenylacetate + 1 H(+) + 1 NADH + 1 O(2) => 1 (3,4-dihydroxyphenyl)acetate + 1 H(2)O + 1 NAD(+)." [] xref: EC:1.14.14.9 xref: GO:0052881 "molecular_function:4-hydroxyphenylacetate 3-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00642 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-hydroxyphenylacetate relationship: has_input_compound UPa:UPC00642 ! 4-hydroxyphenylacetate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC01161 {cardinality="1", is_alternate="False", is_primary="True"} ! (3,4-dihydroxyphenyl)acetate relationship: has_output_compound UPa:UPC01161 ! (3,4-dihydroxyphenyl)acetate relationship: part_of UPa:ULS00199 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate relationship: part_of UPa:ULS00199 {cardinality="1", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate [Term] id: UPa:UER00417 name: pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 2/7 namespace: enzymatic_reaction def: "1 (3,4-dihydroxyphenyl)acetate + 1 O(2) => 1 5-carboxymethyl-2-hydroxymuconate semialdehyde." [] xref: EC:1.13.11.15 xref: GO:0008687 "molecular_function:3,4-dihydroxyphenylacetate 2,3-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC01161 ! (3,4-dihydroxyphenyl)acetate relationship: has_input_compound UPa:UPC01161 {cardinality="1", is_alternate="False", is_primary="True"} ! (3,4-dihydroxyphenyl)acetate relationship: has_output_compound UPa:UPC04642 ! 5-carboxymethyl-2-hydroxymuconate semialdehyde relationship: has_output_compound UPa:UPC04642 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-carboxymethyl-2-hydroxymuconate semialdehyde relationship: part_of UPa:ULS00199 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate relationship: part_of UPa:ULS00199 {cardinality="1", order="2"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate [Term] id: UPa:UER00418 name: pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 3/7 namespace: enzymatic_reaction def: "1 5-carboxymethyl-2-hydroxymuconate semialdehyde + 1 H(2)O + 1 NAD(+) => 1 5-carboxymethyl-2-hydroxymuconic acid + 1 H(+) + 1 NADH." [] xref: EC:1.2.1.60 xref: GO:0018480 "molecular_function:5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC04642 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-carboxymethyl-2-hydroxymuconate semialdehyde relationship: has_input_compound UPa:UPC04642 ! 5-carboxymethyl-2-hydroxymuconate semialdehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC04186 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-carboxymethyl-2-hydroxymuconic acid relationship: has_output_compound UPa:UPC04186 ! 5-carboxymethyl-2-hydroxymuconic acid relationship: part_of UPa:ULS00199 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate relationship: part_of UPa:ULS00199 {cardinality="1", order="3"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate [Term] id: UPa:UER00419 name: pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 4/7 namespace: enzymatic_reaction def: "1 5-carboxymethyl-2-hydroxymuconic acid => 1 5-oxopent-3-ene-1,2,5-tricarboxylic acid." [] xref: EC:5.3.3.10 xref: GO:0008704 "molecular_function:5-carboxymethyl-2-hydroxymuconate delta-isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04186 ! 5-carboxymethyl-2-hydroxymuconic acid relationship: has_input_compound UPa:UPC04186 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-carboxymethyl-2-hydroxymuconic acid relationship: has_output_compound UPa:UPC04052 ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid relationship: has_output_compound UPa:UPC04052 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid relationship: part_of UPa:ULS00199 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate relationship: part_of UPa:ULS00199 {cardinality="1", order="4"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate [Term] id: UPa:UER00420 name: pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 5/7 namespace: enzymatic_reaction def: "1 5-oxopent-3-ene-1,2,5-tricarboxylic acid => 1 2-hydroxy-hept-2,4-diene-1,7-dioic acid + 1 CO(2)." [] xref: EC:4.1.1.68 xref: GO:0018800 "molecular_function:5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04052 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid relationship: has_input_compound UPa:UPC04052 ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC05600 ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid relationship: has_output_compound UPa:UPC05600 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid relationship: part_of UPa:ULS00199 {cardinality="1", order="5"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate relationship: part_of UPa:ULS00199 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate [Term] id: UPa:UER00421 name: pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 6/7 namespace: enzymatic_reaction def: "1 2-hydroxy-hept-2,4-diene-1,7-dioic acid + 1 H(2)O => 1 2,4-dihydroxyhept-2-enedioic acid." [] xref: EC:4.2.1 xref: GO:0008659 "molecular_function:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity" xref: GO:0016836 "molecular_function:hydro-lyase activity" xref: GO:0018807 "molecular_function:6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity" xref: GO:0018808 "molecular_function:trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity" xref: GO:0018809 "molecular_function:E-phenylitaconyl-CoA hydratase activity" xref: GO:0018810 "molecular_function:trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity" xref: GO:0018811 "molecular_function:cyclohex-1-ene-1-carboxyl-CoA hydratase activity" xref: GO:0018812 "molecular_function:3-hydroxyacyl-CoA dehydratase activity" xref: GO:0018813 "molecular_function:trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity" xref: GO:0018815 "molecular_function:3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity" xref: GO:0018816 "molecular_function:2-hydroxyisobutyrate dehydratase activity" xref: GO:0018817 "molecular_function:2-oxo-hept-3-ene-1,7-dioate hydratase activity" xref: GO:0034561 "molecular_function:1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity" xref: GO:0034578 "molecular_function:limonene 8-hydratase activity" xref: GO:0034581 "molecular_function:4-methyloct-2-enoyl-CoA hydratase activity" xref: GO:0034829 "molecular_function:2-hydroxydec-2,4-diene-1,10-dioate hydratase activity" xref: GO:0034839 "molecular_function:menth-2-enone hydratase activity" xref: GO:0034846 "molecular_function:naphthyl-2-methylene-succinyl-CoA lyase activity" xref: GO:0034856 "molecular_function:2-hydroxyhexa-2,4-dienoate hydratase activity" xref: GO:0034867 "molecular_function:2,4,4-trimethylpent-2-enoyl-CoA hydratase activity" xref: GO:0034890 "molecular_function:endosulfan diol hydrolyase (cyclizing) activity" xref: GO:0034904 "molecular_function:5-chloro-2-oxopent-4-enoate hydratase activity" xref: GO:0034917 "molecular_function:2-methylhex-2-enoyl-CoA hydratase activity" xref: GO:0034953 "molecular_function:perillyl-CoA hydratase activity" xref: GO:0043724 "molecular_function:2-keto-3-deoxygalactonate aldolase activity" xref: GO:0043725 "molecular_function:2-keto-3-deoxygluconate aldolase activity" xref: GO:0043956 "molecular_function:3-hydroxypropionyl-CoA dehydratase activity" xref: GO:0043960 "molecular_function:L-erythro-3-methylmalyl-CoA dehydratase activity" xref: GO:0046565 "molecular_function:3-dehydroshikimate dehydratase activity" xref: GO:0051909 "molecular_function:acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate" xref: GO:0052684 "molecular_function:L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity" xref: GO:0052855 "molecular_function:ADP-dependent NAD(P)H-hydrate dehydratase activity" xref: GO:0070497 "molecular_function:6-carboxy-5,6,7,8-tetrahydropterin synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC05600 ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid relationship: has_input_compound UPa:UPC05600 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid relationship: has_output_compound UPa:UPC06201 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,4-dihydroxyhept-2-enedioic acid relationship: has_output_compound UPa:UPC06201 ! 2,4-dihydroxyhept-2-enedioic acid relationship: part_of UPa:ULS00199 {cardinality="1", order="6"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate relationship: part_of UPa:ULS00199 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate [Term] id: UPa:UER00422 name: pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 7/7 namespace: enzymatic_reaction def: "1 2,4-dihydroxyhept-2-enedioic acid => 1 pyruvate + 1 succinate semialdehyde." [] xref: EC:4.1.2.52 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC06201 ! 2,4-dihydroxyhept-2-enedioic acid relationship: has_input_compound UPa:UPC06201 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,4-dihydroxyhept-2-enedioic acid relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00232 ! succinate semialdehyde relationship: has_output_compound UPa:UPC00232 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate semialdehyde relationship: part_of UPa:ULS00199 {cardinality="1", order="7"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate relationship: part_of UPa:ULS00199 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate [Term] id: UPa:UER00423 name: alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2 namespace: enzymatic_reaction def: "1 D-fructose 6-phosphate => 1 D-mannose 6-phosphate." [] xref: EC:5.3.1.8 xref: GO:0004476 "molecular_function:mannose-6-phosphate isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00275 ! D-mannose 6-phosphate relationship: has_output_compound UPa:UPC00275 {cardinality="1", is_alternate="False", is_primary="True"} ! D-mannose 6-phosphate relationship: part_of UPa:ULS00198 {cardinality="1", order="1"} ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate relationship: part_of UPa:ULS00198 ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate [Term] id: UPa:UER00424 name: alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2 namespace: enzymatic_reaction def: "1 D-mannose 6-phosphate => 1 alpha-D-mannose 1-phosphate." [] xref: EC:5.4.2.8 xref: GO:0004615 "molecular_function:phosphomannomutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00275 ! D-mannose 6-phosphate relationship: has_input_compound UPa:UPC00275 {cardinality="1", is_alternate="False", is_primary="True"} ! D-mannose 6-phosphate relationship: has_output_compound UPa:UPC00636 ! alpha-D-mannose 1-phosphate relationship: has_output_compound UPa:UPC00636 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-mannose 1-phosphate relationship: part_of UPa:ULS00198 {cardinality="1", order="2"} ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate relationship: part_of UPa:ULS00198 ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate [Term] id: UPa:UER00425 name: GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GDP route): step 1/1 namespace: enzymatic_reaction def: "1 GDP + 1 alpha-D-mannose 1-phosphate => 1 GDP-alpha-D-mannose + 1 phosphate." [] xref: EC:2.7.7.22 xref: GO:0008928 "molecular_function:mannose-1-phosphate guanylyltransferase (GDP) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00035 ! GDP relationship: has_input_compound UPa:UPC00035 {cardinality="1", is_alternate="False", is_primary="False"} ! GDP relationship: has_input_compound UPa:UPC00636 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-mannose 1-phosphate relationship: has_input_compound UPa:UPC00636 ! alpha-D-mannose 1-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00096 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-alpha-D-mannose relationship: part_of UPa:ULS00463 {cardinality="1", order="1"} ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GDP route) relationship: part_of UPa:ULS00463 ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GDP route) [Term] id: UPa:UER00427 name: glycine from L-allo-threonine: step 1/1 namespace: enzymatic_reaction def: "1 L-allo-threonine => 1 acetaldehyde + 1 glycine." [] xref: EC:4.1.2.49 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC05519 {cardinality="1", is_alternate="False", is_primary="True"} ! L-allo-threonine relationship: has_input_compound UPa:UPC05519 ! L-allo-threonine relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="True"} ! glycine relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: has_output_compound UPa:UPC00084 {cardinality="1", is_alternate="False", is_primary="False"} ! acetaldehyde relationship: part_of UPa:ULS00200 ! glycine from L-allo-threonine relationship: part_of UPa:ULS00200 {cardinality="1", order="1"} ! glycine from L-allo-threonine [Term] id: UPa:UER00428 name: glycine from glyoxylate: step 1/1 namespace: enzymatic_reaction def: "1 L-alanine + 1 glyoxylate => 1 glycine + 1 pyruvate." [] xref: EC:2.6.1.44 xref: GO:0008453 "molecular_function:alanine-glyoxylate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00041 {cardinality="1", is_alternate="False", is_primary="False"} ! L-alanine relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_input_compound UPa:UPC00048 ! glyoxylate relationship: has_input_compound UPa:UPC00048 {cardinality="1", is_alternate="False", is_primary="True"} ! glyoxylate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="True"} ! glycine relationship: part_of UPa:ULS00201 ! glycine from glyoxylate relationship: part_of UPa:ULS00201 {cardinality="1", order="1"} ! glycine from glyoxylate [Term] id: UPa:UER00429 name: acetaldehyde and glycine from L-threonine: step 1/1 namespace: enzymatic_reaction def: "1 L-threonine => 1 acetaldehyde + 1 glycine." [] xref: EC:4.1.2.5 xref: GO:0004793 "molecular_function:threonine aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00188 {cardinality="1", is_alternate="False", is_primary="True"} ! L-threonine relationship: has_input_compound UPa:UPC00188 ! L-threonine relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="True"} ! glycine relationship: has_output_compound UPa:UPC00084 {cardinality="1", is_alternate="False", is_primary="True"} ! acetaldehyde relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: part_of UPa:ULS00202 ! acetaldehyde and glycine from L-threonine relationship: part_of UPa:ULS00202 {cardinality="1", order="1"} ! acetaldehyde and glycine from L-threonine [Term] id: UPa:UER00430 name: betaine aldehyde from choline (monooxygenase route): step 1/1 namespace: enzymatic_reaction def: "2 H(+) + 1 O(2) + 1 choline + 2 reduced ferredoxin => 2 H(2)O + 1 betaine aldehyde + 2 oxidized ferredoxin." [] xref: EC:1.14.15.7 xref: GO:0019133 "molecular_function:choline monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00114 {cardinality="1", is_alternate="False", is_primary="True"} ! choline relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_input_compound UPa:UPC00138 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced ferredoxin relationship: has_input_compound UPa:UPC00138 ! reduced ferredoxin relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00139 ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00139 {cardinality="1", is_alternate="False", is_primary="False"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde relationship: has_output_compound UPa:UPC00576 {cardinality="1", is_alternate="False", is_primary="True"} ! betaine aldehyde relationship: part_of UPa:ULS00203 ! betaine aldehyde from choline (monooxygenase route) relationship: part_of UPa:ULS00203 {cardinality="1", order="1"} ! betaine aldehyde from choline (monooxygenase route) [Term] id: UPa:UER00431 name: choline from choline sulfate: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 choline sulfate => 1 choline + 1 sulfate." [] xref: EC:3.1.6.6 xref: GO:0047753 "molecular_function:choline-sulfatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00919 ! choline sulfate relationship: has_input_compound UPa:UPC00919 {cardinality="1", is_alternate="False", is_primary="True"} ! choline sulfate relationship: has_output_compound UPa:UPC00059 {cardinality="1", is_alternate="False", is_primary="False"} ! sulfate relationship: has_output_compound UPa:UPC00059 ! sulfate relationship: has_output_compound UPa:UPC00114 ! choline relationship: has_output_compound UPa:UPC00114 {cardinality="1", is_alternate="False", is_primary="True"} ! choline relationship: part_of UPa:ULS00204 ! choline from choline sulfate relationship: part_of UPa:ULS00204 {cardinality="1", order="1"} ! choline from choline sulfate [Term] id: UPa:UER00432 name: sarcosine from betaine: step 1/2 namespace: enzymatic_reaction def: "1 L-homocysteine + 1 betaine => 1 L-methionine + 1 N,N-dimethylglycine." [] xref: EC:2.1.1.5 xref: GO:0047150 "molecular_function:betaine-homocysteine S-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="False"} ! L-homocysteine relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_input_compound UPa:UPC00719 ! betaine relationship: has_input_compound UPa:UPC00719 {cardinality="1", is_alternate="False", is_primary="True"} ! betaine relationship: has_output_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="False"} ! L-methionine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC01026 {cardinality="1", is_alternate="False", is_primary="True"} ! N,N-dimethylglycine relationship: has_output_compound UPa:UPC01026 ! N,N-dimethylglycine relationship: part_of UPa:ULS00205 {cardinality="1", order="1"} ! sarcosine from betaine relationship: part_of UPa:ULS00205 ! sarcosine from betaine [Term] id: UPa:UER00433 name: sarcosine from betaine: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 N,N-dimethylglycine + 1 electron-transferring flavoprotein => 1 formaldehyde + 1 reduced electron-transferring flavoprotein + 1 sarcosine." [] xref: EC:1.5.8.4 xref: GO:0047865 "molecular_function:dimethylglycine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC01026 ! N,N-dimethylglycine relationship: has_input_compound UPa:UPC01026 {cardinality="1", is_alternate="False", is_primary="True"} ! N,N-dimethylglycine relationship: has_input_compound UPa:UPC04253 ! electron-transferring flavoprotein relationship: has_input_compound UPa:UPC04253 {cardinality="1", is_alternate="False", is_primary="False"} ! electron-transferring flavoprotein relationship: has_output_compound UPa:UPC00067 {cardinality="1", is_alternate="False", is_primary="False"} ! formaldehyde relationship: has_output_compound UPa:UPC00067 ! formaldehyde relationship: has_output_compound UPa:UPC00213 {cardinality="1", is_alternate="False", is_primary="True"} ! sarcosine relationship: has_output_compound UPa:UPC00213 ! sarcosine relationship: has_output_compound UPa:UPC04570 ! reduced electron-transferring flavoprotein relationship: has_output_compound UPa:UPC04570 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced electron-transferring flavoprotein relationship: part_of UPa:ULS00205 {cardinality="1", order="2"} ! sarcosine from betaine relationship: part_of UPa:ULS00205 ! sarcosine from betaine [Term] id: UPa:UER00434 name: D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 1/2 namespace: enzymatic_reaction def: "1 D-ribulose 5-phosphate + 1 formaldehyde => 1 D-arabino-3-hexulose 6-phosphate." [] xref: EC:4.1.2.43 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00067 ! formaldehyde relationship: has_input_compound UPa:UPC00067 {cardinality="1", is_alternate="False", is_primary="True"} ! formaldehyde relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC06019 ! D-arabino-3-hexulose 6-phosphate relationship: has_output_compound UPa:UPC06019 {cardinality="1", is_alternate="False", is_primary="True"} ! D-arabino-3-hexulose 6-phosphate relationship: part_of UPa:ULS00207 {cardinality="1", order="1"} ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde relationship: part_of UPa:ULS00207 ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde [Term] id: UPa:UER00435 name: D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 2/2 namespace: enzymatic_reaction def: "1 D-arabino-3-hexulose 6-phosphate => 1 D-fructose 6-phosphate." [] xref: EC:5.3.1.27 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC06019 ! D-arabino-3-hexulose 6-phosphate relationship: has_input_compound UPa:UPC06019 {cardinality="1", is_alternate="False", is_primary="True"} ! D-arabino-3-hexulose 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: part_of UPa:ULS00207 ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde relationship: part_of UPa:ULS00207 {cardinality="1", order="2"} ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde [Term] id: UPa:UER00436 name: D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1 namespace: enzymatic_reaction def: "2 sedoheptulose 7-phosphate => 1 D-glycero-alpha-D-manno-heptose 7-phosphate + 1 D-glycero-beta-D-manno-heptose 7-phosphate." [] xref: EC:5.3.1.28 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC05382 ! sedoheptulose 7-phosphate relationship: has_input_compound UPa:UPC05382 {cardinality="1", is_alternate="False", is_primary="True"} ! sedoheptulose 7-phosphate relationship: has_output_compound UPa:UPC07836 ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC07836 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC19878 ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC19878 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: part_of UPa:ULS00235 ! D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate relationship: part_of UPa:ULS00235 {cardinality="1", order="1"} ! D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate [Term] id: UPa:UER00437 name: ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4 namespace: enzymatic_reaction def: "1 ATP + 1 D-glycero-beta-D-manno-heptose 7-phosphate => 1 ADP + 1 D-glycero-beta-D-manno-heptose 1,7-diphosphate." [] xref: EC:2.7.1.167 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC07836 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_input_compound UPa:UPC07836 ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC11472 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycero-beta-D-manno-heptose 1,7-diphosphate relationship: has_output_compound UPa:UPC11472 ! D-glycero-beta-D-manno-heptose 1,7-diphosphate relationship: part_of UPa:ULS00208 {cardinality="1", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate relationship: part_of UPa:ULS00208 ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate [Term] id: UPa:UER00438 name: ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 2/4 namespace: enzymatic_reaction def: "1 D-glycero-beta-D-manno-heptose 1,7-diphosphate + 1 H(2)O => 1 D-glycero-beta-D-manno-heptose 1-phosphate + 1 phosphate." [] xref: EC:3.1.3.82 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC11472 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycero-beta-D-manno-heptose 1,7-diphosphate relationship: has_input_compound UPa:UPC11472 ! D-glycero-beta-D-manno-heptose 1,7-diphosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC07838 ! D-glycero-beta-D-manno-heptose 1-phosphate relationship: has_output_compound UPa:UPC07838 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycero-beta-D-manno-heptose 1-phosphate relationship: part_of UPa:ULS00208 {cardinality="1", order="2"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate relationship: part_of UPa:ULS00208 ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate [Term] id: UPa:UER00439 name: ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4 namespace: enzymatic_reaction def: "1 ATP + 1 D-glycero-beta-D-manno-heptose 1-phosphate => 1 ADP-D-glycero-beta-D-manno-heptose + 1 diphosphate." [] xref: EC:2.7.7.70 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC07838 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycero-beta-D-manno-heptose 1-phosphate relationship: has_input_compound UPa:UPC07838 ! D-glycero-beta-D-manno-heptose 1-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC06397 {cardinality="1", is_alternate="False", is_primary="True"} ! ADP-D-glycero-beta-D-manno-heptose relationship: has_output_compound UPa:UPC06397 ! ADP-D-glycero-beta-D-manno-heptose relationship: part_of UPa:ULS00208 ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate relationship: part_of UPa:ULS00208 {cardinality="1", order="3"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate [Term] id: UPa:UER00440 name: ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4 namespace: enzymatic_reaction def: "1 ADP-D-glycero-beta-D-manno-heptose => 1 ADP-L-glycero-beta-D-manno-heptose." [] xref: EC:5.1.3.20 xref: GO:0008712 "molecular_function:ADP-glyceromanno-heptose 6-epimerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC06397 ! ADP-D-glycero-beta-D-manno-heptose relationship: has_input_compound UPa:UPC06397 {cardinality="1", is_alternate="False", is_primary="True"} ! ADP-D-glycero-beta-D-manno-heptose relationship: has_output_compound UPa:UPC06398 ! ADP-L-glycero-beta-D-manno-heptose relationship: has_output_compound UPa:UPC06398 {cardinality="1", is_alternate="False", is_primary="True"} ! ADP-L-glycero-beta-D-manno-heptose relationship: part_of UPa:ULS00208 {cardinality="1", order="4"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate relationship: part_of UPa:ULS00208 ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate [Term] id: UPa:UER00441 name: (S)-reticuline from (S)-norcoclaurine: step 1/4 namespace: enzymatic_reaction def: "1 (S)-norcoclaurine + 1 S-adenosyl-L-methionine => 1 (S)-coclaurine + 1 S-adenosyl-L-homocysteine." [] xref: EC:2.1.1.128 xref: GO:0030786 "molecular_function:(RS)-norcoclaurine 6-O-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06160 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-norcoclaurine relationship: has_input_compound UPa:UPC06160 ! (S)-norcoclaurine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06161 ! (S)-coclaurine relationship: has_output_compound UPa:UPC06161 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-coclaurine relationship: part_of UPa:ULS00209 {cardinality="1", order="1"} ! (S)-reticuline from (S)-norcoclaurine relationship: part_of UPa:ULS00209 ! (S)-reticuline from (S)-norcoclaurine [Term] id: UPa:UER00442 name: (S)-reticuline from (S)-norcoclaurine: step 2/4 namespace: enzymatic_reaction def: "1 (S)-coclaurine + 1 S-adenosyl-L-methionine => 1 (S)-N-methylcoclaurine + 1 H(+) + 1 S-adenosyl-L-homocysteine." [] xref: EC:2.1.1.140 xref: GO:0030794 "molecular_function:(S)-coclaurine-N-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06161 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-coclaurine relationship: has_input_compound UPa:UPC06161 ! (S)-coclaurine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC05176 ! (S)-N-methylcoclaurine relationship: has_output_compound UPa:UPC05176 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-N-methylcoclaurine relationship: part_of UPa:ULS00209 {cardinality="1", order="2"} ! (S)-reticuline from (S)-norcoclaurine relationship: part_of UPa:ULS00209 ! (S)-reticuline from (S)-norcoclaurine [Term] id: UPa:UER00443 name: (S)-reticuline from (S)-norcoclaurine: step 3/4 namespace: enzymatic_reaction def: "1 (S)-N-methylcoclaurine + 1 H(+) + 1 NADPH + 1 O(2) => 1 (S)-3'-hydroxy-N-methylcoclaurine + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.71 xref: GO:0050593 "molecular_function:N-methylcoclaurine 3'-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC05176 ! (S)-N-methylcoclaurine relationship: has_input_compound UPa:UPC05176 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-N-methylcoclaurine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC05202 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3'-hydroxy-N-methylcoclaurine relationship: has_output_compound UPa:UPC05202 ! (S)-3'-hydroxy-N-methylcoclaurine relationship: part_of UPa:ULS00209 {cardinality="1", order="3"} ! (S)-reticuline from (S)-norcoclaurine relationship: part_of UPa:ULS00209 ! (S)-reticuline from (S)-norcoclaurine [Term] id: UPa:UER00444 name: (S)-reticuline from (S)-norcoclaurine: step 4/4 namespace: enzymatic_reaction def: "1 (S)-3'-hydroxy-N-methylcoclaurine + 1 S-adenosyl-L-methionine => 1 (S)-reticuline + 1 H(+) + 1 S-adenosyl-L-homocysteine." [] xref: EC:2.1.1.116 xref: GO:0030784 "molecular_function:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC05202 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3'-hydroxy-N-methylcoclaurine relationship: has_input_compound UPa:UPC05202 ! (S)-3'-hydroxy-N-methylcoclaurine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC02105 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-reticuline relationship: has_output_compound UPa:UPC02105 ! (S)-reticuline relationship: part_of UPa:ULS00209 {cardinality="1", order="4"} ! (S)-reticuline from (S)-norcoclaurine relationship: part_of UPa:ULS00209 ! (S)-reticuline from (S)-norcoclaurine [Term] id: UPa:UER00445 name: palmatine from columbamine: step 1/1 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 columbamine => 1 S-adenosyl-L-homocysteine + 1 palmatine." [] xref: EC:2.1.1.118 xref: GO:0030778 "molecular_function:columbamine O-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01795 {cardinality="1", is_alternate="False", is_primary="True"} ! columbamine relationship: has_input_compound UPa:UPC01795 ! columbamine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC05315 ! palmatine relationship: has_output_compound UPa:UPC05315 {cardinality="1", is_alternate="False", is_primary="True"} ! palmatine relationship: part_of UPa:ULS00210 {cardinality="1", order="1"} ! palmatine from columbamine relationship: part_of UPa:ULS00210 ! palmatine from columbamine [Term] id: UPa:UER00446 name: berbamunine from (R)-N-methylcoclaurine and (S)-N-methylcoclaurine: step 1/1 namespace: enzymatic_reaction def: "1 (R)-N-methylcoclaurine + 1 (S)-N-methylcoclaurine + 1 H(+) + 1 NADPH + 1 O(2) => 2 H(2)O + 1 NADP(+) + 1 berbamunine." [] xref: EC:1.14.21.3 xref: GO:0047054 "molecular_function:berbamunine synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC05176 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-N-methylcoclaurine relationship: has_input_compound UPa:UPC05176 ! (S)-N-methylcoclaurine relationship: has_input_compound UPa:UPC05243 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-N-methylcoclaurine relationship: has_input_compound UPa:UPC05243 ! (R)-N-methylcoclaurine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC05177 ! berbamunine relationship: has_output_compound UPa:UPC05177 {cardinality="1", is_alternate="False", is_primary="True"} ! berbamunine relationship: part_of UPa:ULS00211 {cardinality="1", order="1"} ! berbamunine from (R)-N-methylcoclaurine and (S)-N-methylcoclaurine relationship: part_of UPa:ULS00211 ! berbamunine from (R)-N-methylcoclaurine and (S)-N-methylcoclaurine [Term] id: UPa:UER00447 name: 3alpha(S)-strictosidine from secologanin and tryptamine: step 1/1 namespace: enzymatic_reaction def: "1 secologanin + 1 tryptamine => 1 3alpha(S)-strictosidine + 1 H(2)O." [] xref: EC:4.3.3.2 xref: GO:0016844 "molecular_function:strictosidine synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00398 ! tryptamine relationship: has_input_compound UPa:UPC00398 {cardinality="1", is_alternate="False", is_primary="True"} ! tryptamine relationship: has_input_compound UPa:UPC01852 {cardinality="1", is_alternate="False", is_primary="True"} ! secologanin relationship: has_input_compound UPa:UPC01852 ! secologanin relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC03470 ! 3alpha(S)-strictosidine relationship: has_output_compound UPa:UPC03470 {cardinality="1", is_alternate="False", is_primary="True"} ! 3alpha(S)-strictosidine relationship: part_of UPa:ULS00212 ! 3alpha(S)-strictosidine from secologanin and tryptamine relationship: part_of UPa:ULS00212 {cardinality="1", order="1"} ! 3alpha(S)-strictosidine from secologanin and tryptamine [Term] id: UPa:UER00448 name: L-cystathionine from O-acetyl-L-homoserine: step 1/1 namespace: enzymatic_reaction def: "1 L-cysteine + 1 O-acetyl-L-homoserine => 1 L-cystathionine + 1 acetate." [] xref: EC:2.5.1 xref: GO:0004659 "molecular_function:prenyltransferase activity" xref: GO:0004661 "molecular_function:protein geranylgeranyltransferase activity" xref: GO:0008318 "molecular_function:protein prenyltransferase activity" xref: GO:0008412 "molecular_function:4-hydroxybenzoate octaprenyltransferase activity" xref: GO:0008495 "molecular_function:protoheme IX farnesyltransferase activity" xref: GO:0016765 "molecular_function:transferase activity, transferring alkyl or aryl (other than methyl) groups" xref: GO:0043888 "molecular_function:(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity" xref: GO:0043918 "molecular_function:cadaverine aminopropyltransferase activity" xref: GO:0043919 "molecular_function:agmatine aminopropyltransferase activity" xref: GO:0046428 "molecular_function:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity" xref: GO:0048045 "molecular_function:trans-pentaprenyltranstransferase activity" xref: GO:0052622 "molecular_function:ATP dimethylallyltransferase activity" xref: GO:0052623 "molecular_function:ADP dimethylallyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="False"} ! L-cysteine relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC01077 ! O-acetyl-L-homoserine relationship: has_input_compound UPa:UPC01077 {cardinality="1", is_alternate="False", is_primary="True"} ! O-acetyl-L-homoserine relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC02291 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cystathionine relationship: has_output_compound UPa:UPC02291 ! L-cystathionine relationship: part_of UPa:ULS00213 ! L-cystathionine from O-acetyl-L-homoserine relationship: part_of UPa:ULS00213 {cardinality="1", order="1"} ! L-cystathionine from O-acetyl-L-homoserine [Term] id: UPa:UER00449 name: L-homocysteine from O-succinyl-L-homoserine: step 1/1 namespace: enzymatic_reaction def: "1 O-succinyl-L-homoserine + 1 hydrogen sulfide => 1 L-homocysteine + 1 succinate." [] xref: EC:2.5.1.48 xref: GO:0003962 "molecular_function:cystathionine gamma-synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_input_compound UPa:UPC00283 {cardinality="1", is_alternate="False", is_primary="False"} ! hydrogen sulfide relationship: has_input_compound UPa:UPC01118 ! O-succinyl-L-homoserine relationship: has_input_compound UPa:UPC01118 {cardinality="1", is_alternate="False", is_primary="True"} ! O-succinyl-L-homoserine relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_output_compound UPa:UPC00155 ! L-homocysteine relationship: part_of UPa:ULS00214 {cardinality="1", order="1"} ! L-homocysteine from O-succinyl-L-homoserine relationship: part_of UPa:ULS00214 ! L-homocysteine from O-succinyl-L-homoserine [Term] id: UPa:UER00450 name: (S)-scoulerine from (S)-reticuline: step 1/1 namespace: enzymatic_reaction def: "1 (S)-reticuline + 1 O(2) => 1 (S)-scoulerine + 1 H(2)O(2)." [] xref: EC:1.21.3.3 xref: GO:0050468 "molecular_function:reticuline oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC02105 ! (S)-reticuline relationship: has_input_compound UPa:UPC02105 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-reticuline relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC02106 ! (S)-scoulerine relationship: has_output_compound UPa:UPC02106 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-scoulerine relationship: part_of UPa:ULS00215 ! (S)-scoulerine from (S)-reticuline relationship: part_of UPa:ULS00215 {cardinality="1", order="1"} ! (S)-scoulerine from (S)-reticuline [Term] id: UPa:UER00451 name: S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1 namespace: enzymatic_reaction def: "1 H(+) + 1 S-adenosyl-L-methionine => 1 CO(2) + 1 S-adenosylmethioninamine." [] xref: EC:4.1.1.50 xref: GO:0004014 "molecular_function:adenosylmethionine decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="True"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC01137 ! S-adenosylmethioninamine relationship: has_output_compound UPa:UPC01137 {cardinality="1", is_alternate="False", is_primary="True"} ! S-adenosylmethioninamine relationship: part_of UPa:ULS00216 ! S-adenosylmethioninamine from S-adenosyl-L-methionine relationship: part_of UPa:ULS00216 {cardinality="1", order="1"} ! S-adenosylmethioninamine from S-adenosyl-L-methionine [Term] id: UPa:UER00452 name: indole and pyruvate from L-tryptophan: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-tryptophan => 1 NH(3) + 1 indole + 1 pyruvate." [] xref: EC:4.1.99.1 xref: GO:0009034 "molecular_function:tryptophanase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00078 ! L-tryptophan relationship: has_input_compound UPa:UPC00078 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tryptophan relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00463 {cardinality="1", is_alternate="False", is_primary="True"} ! indole relationship: has_output_compound UPa:UPC00463 ! indole relationship: part_of UPa:ULS00217 ! indole and pyruvate from L-tryptophan relationship: part_of UPa:ULS00217 {cardinality="1", order="1"} ! indole and pyruvate from L-tryptophan [Term] id: UPa:UER00453 name: L-kynurenine from L-tryptophan: step 1/2 namespace: enzymatic_reaction def: "1 L-tryptophan + 1 O(2) => 1 N-formyl-N-kynurenine." [] xref: EC:1.13.11.11 xref: GO:0004833 "molecular_function:tryptophan 2,3-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00078 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tryptophan relationship: has_input_compound UPa:UPC00078 ! L-tryptophan relationship: has_output_compound UPa:UPC02700 {cardinality="1", is_alternate="False", is_primary="True"} ! N-formyl-N-kynurenine relationship: has_output_compound UPa:UPC02700 ! N-formyl-N-kynurenine relationship: part_of UPa:ULS00218 ! L-kynurenine from L-tryptophan relationship: part_of UPa:ULS00218 {cardinality="1", order="1"} ! L-kynurenine from L-tryptophan [Term] id: UPa:UER00454 name: L-kynurenine from L-tryptophan: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-formyl-N-kynurenine => 1 L-kynurenine + 1 formate." [] xref: EC:3.5.1.9 xref: GO:0004061 "molecular_function:arylformamidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC02700 {cardinality="1", is_alternate="False", is_primary="True"} ! N-formyl-N-kynurenine relationship: has_input_compound UPa:UPC02700 ! N-formyl-N-kynurenine relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00328 ! L-kynurenine relationship: has_output_compound UPa:UPC00328 {cardinality="1", is_alternate="False", is_primary="True"} ! L-kynurenine relationship: part_of UPa:ULS00218 ! L-kynurenine from L-tryptophan relationship: part_of UPa:ULS00218 {cardinality="1", order="2"} ! L-kynurenine from L-tryptophan [Term] id: UPa:UER00455 name: L-alanine and anthranilate from L-kynurenine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-kynurenine => 1 L-alanine + 1 anthranilate." [] xref: EC:3.7.1.3 xref: GO:0030429 "molecular_function:kynureninase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00328 {cardinality="1", is_alternate="False", is_primary="True"} ! L-kynurenine relationship: has_input_compound UPa:UPC00328 ! L-kynurenine relationship: has_output_compound UPa:UPC00041 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alanine relationship: has_output_compound UPa:UPC00041 ! L-alanine relationship: has_output_compound UPa:UPC00108 ! anthranilate relationship: has_output_compound UPa:UPC00108 {cardinality="1", is_alternate="False", is_primary="True"} ! anthranilate relationship: part_of UPa:ULS00219 ! L-alanine and anthranilate from L-kynurenine relationship: part_of UPa:ULS00219 {cardinality="1", order="1"} ! L-alanine and anthranilate from L-kynurenine [Term] id: UPa:UER00456 name: iminoaspartate from L-aspartate (dehydrogenase route): step 1/1 namespace: enzymatic_reaction def: "L-aspartate + [NAD(+) or NADP(+)] => H(+) + iminoaspartate + [NADH or NADPH]." [] xref: EC:1.4.1.21 xref: GO:0033735 "molecular_function:aspartate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00963 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00964 ! None relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC05840 {cardinality="1", is_alternate="False", is_primary="True"} ! iminoaspartate relationship: has_output_compound UPa:UPC05840 ! iminoaspartate relationship: part_of UPa:ULS00220 ! iminoaspartate from L-aspartate (dehydrogenase route) relationship: part_of UPa:ULS00220 {cardinality="1", order="1"} ! iminoaspartate from L-aspartate (dehydrogenase route) [Term] id: UPa:UER00457 name: nicotinate D-ribonucleotide from nicotinate: step 1/1 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 ATP + 1 H(+) + 1 H(2)O + 1 nicotinate => 1 ADP + 1 diphosphate + 1 nicotinate D-ribonucleotide + 1 phosphate." [] xref: EC:6.3.4.21 xref: GO:0004516 "molecular_function:nicotinate phosphoribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00253 ! nicotinate relationship: has_input_compound UPa:UPC00253 {cardinality="1", is_alternate="False", is_primary="True"} ! nicotinate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC01185 ! nicotinate D-ribonucleotide relationship: has_output_compound UPa:UPC01185 {cardinality="1", is_alternate="False", is_primary="True"} ! nicotinate D-ribonucleotide relationship: part_of UPa:ULS00223 {cardinality="1", order="1"} ! nicotinate D-ribonucleotide from nicotinate relationship: part_of UPa:ULS00223 ! nicotinate D-ribonucleotide from nicotinate [Term] id: UPa:UER00458 name: acetyl-CoA from acetate: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 acetate => 1 ADP + 1 acetyl phosphate." [] xref: EC:2.7.2.1 xref: GO:0008776 "molecular_function:acetate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="True"} ! acetate relationship: has_input_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00227 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl phosphate relationship: has_output_compound UPa:UPC00227 ! acetyl phosphate relationship: part_of UPa:ULS00224 {cardinality="1", order="1"} ! acetyl-CoA from acetate relationship: part_of UPa:ULS00224 ! acetyl-CoA from acetate [Term] id: UPa:UER00459 name: acetyl-CoA from acetate: step 2/2 namespace: enzymatic_reaction def: "1 CoA + 1 acetyl phosphate => 1 acetyl-CoA + 1 phosphate." [] xref: EC:2.3.1.8 xref: GO:0008959 "molecular_function:phosphate acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00227 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl phosphate relationship: has_input_compound UPa:UPC00227 ! acetyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: part_of UPa:ULS00224 ! acetyl-CoA from acetate relationship: part_of UPa:ULS00224 {cardinality="1", order="2"} ! acetyl-CoA from acetate [Term] id: UPa:UER00461 name: L-threonine from L-aspartate: step 1/5 namespace: enzymatic_reaction def: "1 ATP + 1 L-aspartate => 1 4-phospho-L-aspartate + 1 ADP." [] xref: EC:2.7.2.4 xref: GO:0004072 "molecular_function:aspartate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC03082 ! 4-phospho-L-aspartate relationship: has_output_compound UPa:UPC03082 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-phospho-L-aspartate relationship: part_of UPa:ULS00022 {cardinality="1", order="1"} ! L-threonine from L-aspartate relationship: part_of UPa:ULS00022 ! L-threonine from L-aspartate [Term] id: UPa:UER00462 name: L-homoserine from L-aspartate: step 1/3 namespace: enzymatic_reaction def: "1 ATP + 1 L-aspartate => 1 4-phospho-L-aspartate + 1 ADP." [] xref: EC:2.7.2.4 xref: GO:0004072 "molecular_function:aspartate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC03082 ! 4-phospho-L-aspartate relationship: has_output_compound UPa:UPC03082 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-phospho-L-aspartate relationship: part_of UPa:ULS00025 {cardinality="1", order="1"} ! L-homoserine from L-aspartate relationship: part_of UPa:ULS00025 ! L-homoserine from L-aspartate [Term] id: UPa:UER00463 name: L-threonine from L-aspartate: step 2/5 namespace: enzymatic_reaction def: "1 4-phospho-L-aspartate + 1 H(+) + 1 NADPH => 1 L-aspartate 4-semialdehyde + 1 NADP(+) + 1 phosphate." [] xref: EC:1.2.1.11 xref: GO:0004073 "molecular_function:aspartate-semialdehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC03082 ! 4-phospho-L-aspartate relationship: has_input_compound UPa:UPC03082 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-phospho-L-aspartate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: part_of UPa:ULS00022 {cardinality="1", order="2"} ! L-threonine from L-aspartate relationship: part_of UPa:ULS00022 ! L-threonine from L-aspartate [Term] id: UPa:UER00464 name: L-homoserine from L-aspartate: step 2/3 namespace: enzymatic_reaction def: "1 4-phospho-L-aspartate + 1 H(+) + 1 NADPH => 1 L-aspartate 4-semialdehyde + 1 NADP(+) + 1 phosphate." [] xref: EC:1.2.1.11 xref: GO:0004073 "molecular_function:aspartate-semialdehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC03082 ! 4-phospho-L-aspartate relationship: has_input_compound UPa:UPC03082 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-phospho-L-aspartate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: part_of UPa:ULS00025 {cardinality="1", order="2"} ! L-homoserine from L-aspartate relationship: part_of UPa:ULS00025 ! L-homoserine from L-aspartate [Term] id: UPa:UER00465 name: L-homoserine from L-aspartate: step 3/3 namespace: enzymatic_reaction def: "H(+) + L-aspartate 4-semialdehyde + [NADH or NADPH] => L-homoserine + [NAD(+) or NADP(+)]." [] xref: EC:1.1.1.3 xref: GO:0004412 "molecular_function:homoserine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00949 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00950 ! None relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00263 ! L-homoserine relationship: has_output_compound UPa:UPC00263 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homoserine relationship: part_of UPa:ULS00025 {cardinality="1", order="3"} ! L-homoserine from L-aspartate relationship: part_of UPa:ULS00025 ! L-homoserine from L-aspartate [Term] id: UPa:UER00466 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1 namespace: enzymatic_reaction def: "1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 L-glutamate => 1 2-oxoglutarate + 1 LL-2,6-diaminopimelate." [] xref: EC:2.6.1.83 xref: GO:0010285 "molecular_function:L,L-diaminopimelate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC03972 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00666 {cardinality="1", is_alternate="False", is_primary="True"} ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00666 ! LL-2,6-diaminopimelate relationship: part_of UPa:ULS00227 {cardinality="1", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route) relationship: part_of UPa:ULS00227 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route) [Term] id: UPa:UER00467 name: D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2 namespace: enzymatic_reaction def: "1 2-deoxy-alpha-D-ribose 1-phosphate => 1 2-deoxy-D-ribose 5-phosphate." [] xref: EC:5.4.2.7 xref: GO:0008973 "molecular_function:phosphopentomutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00672 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxy-alpha-D-ribose 1-phosphate relationship: has_input_compound UPa:UPC00672 ! 2-deoxy-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC00673 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxy-D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00673 ! 2-deoxy-D-ribose 5-phosphate relationship: part_of UPa:ULS00228 {cardinality="1", order="1"} ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00228 ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate [Term] id: UPa:UER00468 name: D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2 namespace: enzymatic_reaction def: "1 2-deoxy-D-ribose 5-phosphate => 1 D-glyceraldehyde 3-phosphate + 1 acetaldehyde." [] xref: EC:4.1.2.4 xref: GO:0004139 "molecular_function:deoxyribose-phosphate aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00673 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxy-D-ribose 5-phosphate relationship: has_input_compound UPa:UPC00673 ! 2-deoxy-D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: has_output_compound UPa:UPC00084 {cardinality="1", is_alternate="False", is_primary="True"} ! acetaldehyde relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00228 {cardinality="1", order="2"} ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00228 ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate [Term] id: UPa:UER00469 name: sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 1/4 namespace: enzymatic_reaction def: "1 phosphoenolpyruvate + 1 sulfite => 1 (2R)-O-phospho-3-sulfolactic acid." [] xref: EC:4.4.1.19 xref: GO:0043817 "molecular_function:phosphosulfolactate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00074 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00094 ! sulfite relationship: has_input_compound UPa:UPC00094 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfite relationship: has_output_compound UPa:UPC11536 ! (2R)-O-phospho-3-sulfolactic acid relationship: has_output_compound UPa:UPC11536 {cardinality="1", is_alternate="False", is_primary="True"} ! (2R)-O-phospho-3-sulfolactic acid relationship: part_of UPa:ULS00015 {cardinality="1", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite relationship: part_of UPa:ULS00015 ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite [Term] id: UPa:UER00470 name: sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 2/4 namespace: enzymatic_reaction def: "1 (2R)-O-phospho-3-sulfolactic acid + 1 H(2)O => 1 (R)-3-sulfolactate + 1 phosphate." [] xref: EC:3.1.3.71 xref: GO:0050532 "molecular_function:2-phosphosulfolactate phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC11536 {cardinality="1", is_alternate="False", is_primary="True"} ! (2R)-O-phospho-3-sulfolactic acid relationship: has_input_compound UPa:UPC11536 ! (2R)-O-phospho-3-sulfolactic acid relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC11537 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-3-sulfolactate relationship: has_output_compound UPa:UPC11537 ! (R)-3-sulfolactate relationship: part_of UPa:ULS00015 ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite relationship: part_of UPa:ULS00015 {cardinality="1", order="2"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite [Term] id: UPa:UER00471 name: sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 3/4 namespace: enzymatic_reaction def: "1 (R)-3-sulfolactate + 1 NAD(+) => 1 3-sulfopyruvate + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.272 xref: GO:0050578 "molecular_function:(R)-2-hydroxyacid dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC11537 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-3-sulfolactate relationship: has_input_compound UPa:UPC11537 ! (R)-3-sulfolactate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC05528 ! 3-sulfopyruvate relationship: has_output_compound UPa:UPC05528 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-sulfopyruvate relationship: part_of UPa:ULS00015 ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite relationship: part_of UPa:ULS00015 {cardinality="1", order="3"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite [Term] id: UPa:UER00472 name: sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 4/4 namespace: enzymatic_reaction def: "1 3-sulfopyruvate => 1 CO(2) + 1 sulfoacetaldehyde." [] xref: EC:4.1.1.79 xref: GO:0050545 "molecular_function:sulfopyruvate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC05528 ! 3-sulfopyruvate relationship: has_input_compound UPa:UPC05528 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-sulfopyruvate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00593 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfoacetaldehyde relationship: has_output_compound UPa:UPC00593 ! sulfoacetaldehyde relationship: part_of UPa:ULS00015 ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite relationship: part_of UPa:ULS00015 {cardinality="1", order="4"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite [Term] id: UPa:UER00473 name: 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 1/3 namespace: enzymatic_reaction def: "1 D-ribulose 5-phosphate => 1 D-arabinose 5-phosphate." [] xref: EC:5.3.1.13 xref: GO:0019146 "molecular_function:arabinose-5-phosphate isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00199 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC01112 ! D-arabinose 5-phosphate relationship: has_output_compound UPa:UPC01112 {cardinality="1", is_alternate="False", is_primary="True"} ! D-arabinose 5-phosphate relationship: part_of UPa:ULS00017 ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate relationship: part_of UPa:ULS00017 {cardinality="1", order="1"} ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate [Term] id: UPa:UER00474 name: 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3 namespace: enzymatic_reaction def: "1 D-arabinose 5-phosphate + 1 H(2)O + 1 phosphoenolpyruvate => 1 8-phospho-3-deoxy-D-manno-octulosonate + 1 phosphate." [] xref: EC:2.5.1.55 xref: GO:0008676 "molecular_function:3-deoxy-8-phosphooctulonate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00074 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC01112 {cardinality="1", is_alternate="False", is_primary="True"} ! D-arabinose 5-phosphate relationship: has_input_compound UPa:UPC01112 ! D-arabinose 5-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC04478 {cardinality="1", is_alternate="False", is_primary="True"} ! 8-phospho-3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC04478 ! 8-phospho-3-deoxy-D-manno-octulosonate relationship: part_of UPa:ULS00017 ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate relationship: part_of UPa:ULS00017 {cardinality="1", order="2"} ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate [Term] id: UPa:UER00475 name: 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 3/3 namespace: enzymatic_reaction def: "1 8-phospho-3-deoxy-D-manno-octulosonate + 1 H(2)O => 1 3-deoxy-D-manno-octulosonate + 1 phosphate." [] xref: EC:3.1.3.45 xref: GO:0019143 "molecular_function:3-deoxy-manno-octulosonate-8-phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC04478 ! 8-phospho-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC04478 {cardinality="1", is_alternate="False", is_primary="True"} ! 8-phospho-3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC01187 ! 3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC01187 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-deoxy-D-manno-octulosonate relationship: part_of UPa:ULS00017 ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate relationship: part_of UPa:ULS00017 {cardinality="1", order="3"} ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate [Term] id: UPa:UER00476 name: CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1 namespace: enzymatic_reaction def: "1 3-deoxy-D-manno-octulosonate + 1 CTP => 1 CMP-3-deoxy-D-manno-octulosonate + 1 diphosphate." [] xref: EC:2.7.7.38 xref: GO:0008690 "molecular_function:3-deoxy-manno-octulosonate cytidylyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00063 {cardinality="1", is_alternate="False", is_primary="True"} ! CTP relationship: has_input_compound UPa:UPC01187 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC01187 ! 3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC04121 ! CMP-3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC04121 {cardinality="1", is_alternate="False", is_primary="True"} ! CMP-3-deoxy-D-manno-octulosonate relationship: part_of UPa:ULS00108 {cardinality="1", order="1"} ! CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP relationship: part_of UPa:ULS00108 ! CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP [Term] id: UPa:UER00477 name: lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6 namespace: enzymatic_reaction def: "1 (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + 1 UDP-N-acetyl-alpha-D-glucosamine => 1 UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + 1 acyl-carrier protein." [] xref: EC:2.3.1.129 xref: GO:0008780 "molecular_function:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00043 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-N-acetyl-alpha-D-glucosamine relationship: has_input_compound UPa:UPC00043 ! UDP-N-acetyl-alpha-D-glucosamine relationship: has_input_compound UPa:UPC04688 ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC04688 {cardinality="1", is_alternate="False", is_primary="True"} ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] relationship: has_output_compound UPa:UPC00229 {cardinality="1", is_alternate="False", is_primary="False"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein relationship: has_output_compound UPa:UPC04738 ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine relationship: has_output_compound UPa:UPC04738 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine relationship: part_of UPa:ULS00229 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine relationship: part_of UPa:ULS00229 {cardinality="1", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine [Term] id: UPa:UER00478 name: lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6 namespace: enzymatic_reaction def: "1 H(2)O + 1 UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine => 1 UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine + 1 acetate." [] xref: EC:3.5.1.108 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04738 ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine relationship: has_input_compound UPa:UPC04738 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC06022 ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_output_compound UPa:UPC06022 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine relationship: part_of UPa:ULS00229 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine relationship: part_of UPa:ULS00229 {cardinality="1", order="2"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine [Term] id: UPa:UER00479 name: lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6 namespace: enzymatic_reaction def: "1 (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + 1 UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine => 1 UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine + 1 acyl-carrier protein." [] xref: EC:2.3.1.191 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04688 ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC04688 {cardinality="1", is_alternate="False", is_primary="False"} ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC06022 ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_input_compound UPa:UPC06022 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_output_compound UPa:UPC00229 {cardinality="1", is_alternate="False", is_primary="False"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein relationship: has_output_compound UPa:UPC04652 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_output_compound UPa:UPC04652 ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: part_of UPa:ULS00229 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine relationship: part_of UPa:ULS00229 {cardinality="1", order="3"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine [Term] id: UPa:UER00480 name: lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6 namespace: enzymatic_reaction def: "1 H(2)O + 1 UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine => 1 UMP + 1 lipid X." [] xref: EC:3.6.1.54 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04652 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_input_compound UPa:UPC04652 ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_output_compound UPa:UPC00105 ! UMP relationship: has_output_compound UPa:UPC00105 {cardinality="1", is_alternate="False", is_primary="False"} ! UMP relationship: has_output_compound UPa:UPC04824 {cardinality="1", is_alternate="False", is_primary="True"} ! lipid X relationship: has_output_compound UPa:UPC04824 ! lipid X relationship: part_of UPa:ULS00229 {cardinality="1", order="4"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine relationship: part_of UPa:ULS00229 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine [Term] id: UPa:UER00481 name: lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6 namespace: enzymatic_reaction def: "1 UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine + 1 lipid X => 1 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + 1 UDP." [] xref: EC:2.4.1.182 xref: GO:0008915 "molecular_function:lipid-A-disaccharide synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04652 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_input_compound UPa:UPC04652 ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_input_compound UPa:UPC04824 {cardinality="1", is_alternate="False", is_primary="True"} ! lipid X relationship: has_input_compound UPa:UPC04824 ! lipid X relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00015 {cardinality="1", is_alternate="False", is_primary="False"} ! UDP relationship: has_output_compound UPa:UPC04932 ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC04932 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate relationship: part_of UPa:ULS00229 {cardinality="1", order="5"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine relationship: part_of UPa:ULS00229 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine [Term] id: UPa:UER00482 name: lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6 namespace: enzymatic_reaction def: "1 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + 1 ATP => 1 ADP + 1 lipid IV(A)." [] xref: EC:2.7.1.130 xref: GO:0009029 "molecular_function:tetraacyldisaccharide 4'-kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC04932 ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate relationship: has_input_compound UPa:UPC04932 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC04919 ! lipid IV(A) relationship: has_output_compound UPa:UPC04919 {cardinality="1", is_alternate="False", is_primary="True"} ! lipid IV(A) relationship: part_of UPa:ULS00229 {cardinality="1", order="6"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine relationship: part_of UPa:ULS00229 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine [Term] id: UPa:UER00483 name: KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 1/4 namespace: enzymatic_reaction def: "1 CMP-3-deoxy-D-manno-octulosonate + 1 lipid IV(A) => 1 3-deoxy-D-manno-octulosonyl-lipid IV((A)) + 1 CMP." [] xref: EC:2.4.99.12 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04121 ! CMP-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC04121 {cardinality="1", is_alternate="False", is_primary="True"} ! CMP-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC04919 ! lipid IV(A) relationship: has_input_compound UPa:UPC04919 {cardinality="1", is_alternate="False", is_primary="True"} ! lipid IV(A) relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="False"} ! CMP relationship: has_output_compound UPa:UPC06024 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-deoxy-D-manno-octulosonyl-lipid IV((A)) relationship: has_output_compound UPa:UPC06024 ! 3-deoxy-D-manno-octulosonyl-lipid IV((A)) relationship: part_of UPa:ULS00230 {cardinality="1", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A) relationship: part_of UPa:ULS00230 ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A) [Term] id: UPa:UER00484 name: KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 2/4 namespace: enzymatic_reaction def: "1 3-deoxy-D-manno-octulosonyl-lipid IV((A)) + 1 CMP-3-deoxy-D-manno-octulosonate => 1 CMP + 1 di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)." [] xref: EC:2.4.99.13 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04121 ! CMP-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC04121 {cardinality="1", is_alternate="False", is_primary="True"} ! CMP-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC06024 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-deoxy-D-manno-octulosonyl-lipid IV((A)) relationship: has_input_compound UPa:UPC06024 ! 3-deoxy-D-manno-octulosonyl-lipid IV((A)) relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="False"} ! CMP relationship: has_output_compound UPa:UPC06025 {cardinality="1", is_alternate="False", is_primary="True"} ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) relationship: has_output_compound UPa:UPC06025 ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) relationship: part_of UPa:ULS00230 {cardinality="1", order="2"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A) relationship: part_of UPa:ULS00230 ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A) [Term] id: UPa:UER00485 name: KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 3/4 namespace: enzymatic_reaction def: "1 di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) + 1 dodecanoyl-[acyl-carrier protein] => 1 acyl-carrier protein + 1 lauroyl-KDO(2)-lipid IV(A)." [] xref: EC:2.3.1 xref: GO:0004147 "molecular_function:dihydrolipoamide branched chain acyltransferase activity" xref: GO:0004772 "molecular_function:sterol O-acyltransferase activity" xref: GO:0008080 "molecular_function:N-acetyltransferase activity" xref: GO:0008374 "molecular_function:O-acyltransferase activity" xref: GO:0008951 "molecular_function:palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity" xref: GO:0016406 "molecular_function:carnitine O-acyltransferase activity" xref: GO:0016407 "molecular_function:acetyltransferase activity" xref: GO:0016408 "molecular_function:C-acyltransferase activity" xref: GO:0016409 "molecular_function:palmitoyltransferase activity" xref: GO:0016410 "molecular_function:N-acyltransferase activity" xref: GO:0016411 "molecular_function:acylglycerol O-acyltransferase activity" xref: GO:0016412 "molecular_function:serine O-acyltransferase activity" xref: GO:0016413 "molecular_function:O-acetyltransferase activity" xref: GO:0016414 "molecular_function:O-octanoyltransferase activity" xref: GO:0016415 "molecular_function:octanoyltransferase activity" xref: GO:0016416 "molecular_function:O-palmitoyltransferase activity" xref: GO:0016417 "molecular_function:S-acyltransferase activity" xref: GO:0016418 "molecular_function:S-acetyltransferase activity" xref: GO:0016419 "molecular_function:S-malonyltransferase activity" xref: GO:0016420 "molecular_function:malonyltransferase activity" xref: GO:0016454 "molecular_function:C-palmitoyltransferase activity" xref: GO:0016747 "molecular_function:transferase activity, transferring acyl groups other than amino-acyl groups" xref: GO:0016748 "molecular_function:succinyltransferase activity" xref: GO:0016749 "molecular_function:N-succinyltransferase activity" xref: GO:0016750 "molecular_function:O-succinyltransferase activity" xref: GO:0016751 "molecular_function:S-succinyltransferase activity" xref: GO:0016752 "molecular_function:sinapoyltransferase activity" xref: GO:0016753 "molecular_function:O-sinapoyltransferase activity" xref: GO:0018030 "molecular_function:peptidyl-lysine N6-myristoyltransferase activity" xref: GO:0018031 "molecular_function:peptidyl-lysine N6-palmitoyltransferase activity" xref: GO:0018711 "molecular_function:benzoyl acetate-CoA thiolase activity" xref: GO:0018712 "molecular_function:3-hydroxybutyryl-CoA thiolase activity" xref: GO:0018713 "molecular_function:3-ketopimelyl-CoA thiolase activity" xref: GO:0019105 "molecular_function:N-palmitoyltransferase activity" xref: GO:0019107 "molecular_function:myristoyltransferase activity" xref: GO:0019186 "molecular_function:acyl-CoA N-acyltransferase activity" xref: GO:0019705 "molecular_function:protein-cysteine S-myristoyltransferase activity" xref: GO:0019707 "molecular_function:protein-cysteine S-acyltransferase activity" xref: GO:0030523 "molecular_function:dihydrolipoamide S-acyltransferase activity" xref: GO:0032216 "molecular_function:glucosaminyl-phosphotidylinositol O-acyltransferase activity" xref: GO:0034737 "molecular_function:ergosterol O-acyltransferase activity" xref: GO:0034738 "molecular_function:lanosterol O-acyltransferase activity" xref: GO:0034848 "molecular_function:naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity" xref: GO:0034851 "molecular_function:2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity" xref: GO:0034915 "molecular_function:2-methylhexanoyl-CoA C-acetyltransferase activity" xref: GO:0034919 "molecular_function:butyryl-CoA 2-C-propionyltransferase activity" xref: GO:0034945 "molecular_function:2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity" xref: GO:0043741 "molecular_function:L-2-aminoadipate N-acetyltransferase activity" xref: GO:0043764 "molecular_function:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity" xref: GO:0043806 "molecular_function:keto acid formate lyase activity" xref: GO:0043849 "molecular_function:Ras palmitoyltransferase activity" xref: GO:0043875 "molecular_function:2-ketobutyrate formate-lyase activity" xref: GO:0046941 "molecular_function:azetidine-2-carboxylic acid acetyltransferase activity" xref: GO:0052858 "molecular_function:peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor" xref: GO:0090595 "molecular_function:acetyl-CoA:L-lysine N6-acetyltransferase" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC05223 ! dodecanoyl-[acyl-carrier protein] relationship: has_input_compound UPa:UPC05223 {cardinality="1", is_alternate="False", is_primary="False"} ! dodecanoyl-[acyl-carrier protein] relationship: has_input_compound UPa:UPC06025 {cardinality="1", is_alternate="False", is_primary="True"} ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) relationship: has_input_compound UPa:UPC06025 ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) relationship: has_output_compound UPa:UPC00229 {cardinality="1", is_alternate="False", is_primary="False"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein relationship: has_output_compound UPa:UPC06251 {cardinality="1", is_alternate="False", is_primary="True"} ! lauroyl-KDO(2)-lipid IV(A) relationship: has_output_compound UPa:UPC06251 ! lauroyl-KDO(2)-lipid IV(A) relationship: part_of UPa:ULS00230 {cardinality="1", order="3"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A) relationship: part_of UPa:ULS00230 ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A) [Term] id: UPa:UER00486 name: KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4 namespace: enzymatic_reaction def: "1 lauroyl-KDO(2)-lipid IV(A) + 1 tetradecanoyl-[acp] => 1 KDO(2)-lipid A + 1 acyl-carrier protein." [] xref: EC:2.3.1 xref: GO:0004147 "molecular_function:dihydrolipoamide branched chain acyltransferase activity" xref: GO:0004772 "molecular_function:sterol O-acyltransferase activity" xref: GO:0008080 "molecular_function:N-acetyltransferase activity" xref: GO:0008374 "molecular_function:O-acyltransferase activity" xref: GO:0008951 "molecular_function:palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity" xref: GO:0016406 "molecular_function:carnitine O-acyltransferase activity" xref: GO:0016407 "molecular_function:acetyltransferase activity" xref: GO:0016408 "molecular_function:C-acyltransferase activity" xref: GO:0016409 "molecular_function:palmitoyltransferase activity" xref: GO:0016410 "molecular_function:N-acyltransferase activity" xref: GO:0016411 "molecular_function:acylglycerol O-acyltransferase activity" xref: GO:0016412 "molecular_function:serine O-acyltransferase activity" xref: GO:0016413 "molecular_function:O-acetyltransferase activity" xref: GO:0016414 "molecular_function:O-octanoyltransferase activity" xref: GO:0016415 "molecular_function:octanoyltransferase activity" xref: GO:0016416 "molecular_function:O-palmitoyltransferase activity" xref: GO:0016417 "molecular_function:S-acyltransferase activity" xref: GO:0016418 "molecular_function:S-acetyltransferase activity" xref: GO:0016419 "molecular_function:S-malonyltransferase activity" xref: GO:0016420 "molecular_function:malonyltransferase activity" xref: GO:0016454 "molecular_function:C-palmitoyltransferase activity" xref: GO:0016747 "molecular_function:transferase activity, transferring acyl groups other than amino-acyl groups" xref: GO:0016748 "molecular_function:succinyltransferase activity" xref: GO:0016749 "molecular_function:N-succinyltransferase activity" xref: GO:0016750 "molecular_function:O-succinyltransferase activity" xref: GO:0016751 "molecular_function:S-succinyltransferase activity" xref: GO:0016752 "molecular_function:sinapoyltransferase activity" xref: GO:0016753 "molecular_function:O-sinapoyltransferase activity" xref: GO:0018030 "molecular_function:peptidyl-lysine N6-myristoyltransferase activity" xref: GO:0018031 "molecular_function:peptidyl-lysine N6-palmitoyltransferase activity" xref: GO:0018711 "molecular_function:benzoyl acetate-CoA thiolase activity" xref: GO:0018712 "molecular_function:3-hydroxybutyryl-CoA thiolase activity" xref: GO:0018713 "molecular_function:3-ketopimelyl-CoA thiolase activity" xref: GO:0019105 "molecular_function:N-palmitoyltransferase activity" xref: GO:0019107 "molecular_function:myristoyltransferase activity" xref: GO:0019186 "molecular_function:acyl-CoA N-acyltransferase activity" xref: GO:0019705 "molecular_function:protein-cysteine S-myristoyltransferase activity" xref: GO:0019707 "molecular_function:protein-cysteine S-acyltransferase activity" xref: GO:0030523 "molecular_function:dihydrolipoamide S-acyltransferase activity" xref: GO:0032216 "molecular_function:glucosaminyl-phosphotidylinositol O-acyltransferase activity" xref: GO:0034737 "molecular_function:ergosterol O-acyltransferase activity" xref: GO:0034738 "molecular_function:lanosterol O-acyltransferase activity" xref: GO:0034848 "molecular_function:naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity" xref: GO:0034851 "molecular_function:2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity" xref: GO:0034915 "molecular_function:2-methylhexanoyl-CoA C-acetyltransferase activity" xref: GO:0034919 "molecular_function:butyryl-CoA 2-C-propionyltransferase activity" xref: GO:0034945 "molecular_function:2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity" xref: GO:0043741 "molecular_function:L-2-aminoadipate N-acetyltransferase activity" xref: GO:0043764 "molecular_function:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity" xref: GO:0043806 "molecular_function:keto acid formate lyase activity" xref: GO:0043849 "molecular_function:Ras palmitoyltransferase activity" xref: GO:0043875 "molecular_function:2-ketobutyrate formate-lyase activity" xref: GO:0046941 "molecular_function:azetidine-2-carboxylic acid acetyltransferase activity" xref: GO:0052858 "molecular_function:peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor" xref: GO:0090595 "molecular_function:acetyl-CoA:L-lysine N6-acetyltransferase" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC05761 {cardinality="1", is_alternate="False", is_primary="False"} ! tetradecanoyl-[acp] relationship: has_input_compound UPa:UPC05761 ! tetradecanoyl-[acp] relationship: has_input_compound UPa:UPC06251 {cardinality="1", is_alternate="False", is_primary="True"} ! lauroyl-KDO(2)-lipid IV(A) relationship: has_input_compound UPa:UPC06251 ! lauroyl-KDO(2)-lipid IV(A) relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein relationship: has_output_compound UPa:UPC00229 {cardinality="1", is_alternate="False", is_primary="False"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC06026 {cardinality="1", is_alternate="False", is_primary="True"} ! KDO(2)-lipid A relationship: has_output_compound UPa:UPC06026 ! KDO(2)-lipid A relationship: part_of UPa:ULS00230 {cardinality="1", order="4"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A) relationship: part_of UPa:ULS00230 ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A) [Term] id: UPa:UER00487 name: 6-hydroxypseudooxynicotine from nicotine (S-isomer route): step 1/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 acceptor + 1 nicotine => 1 (S)-6-hydroxynicotine + 1 reduced acceptor." [] xref: EC:1.5.99.4 xref: GO:0018535 "molecular_function:nicotine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_input_compound UPa:UPC16150 {cardinality="1", is_alternate="False", is_primary="True"} ! nicotine relationship: has_input_compound UPa:UPC16150 ! nicotine relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_output_compound UPa:UPC01056 ! (S)-6-hydroxynicotine relationship: has_output_compound UPa:UPC01056 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-6-hydroxynicotine relationship: part_of UPa:ULS00453 {cardinality="1", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route) relationship: part_of UPa:ULS00453 ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route) [Term] id: UPa:UER00488 name: 6-hydroxypseudooxynicotine from nicotine (R-isomer route): step 2/2 namespace: enzymatic_reaction def: "1 (R)-6-hydroxynicotine + 1 H(2)O + 1 O(2) => 1 6-hydroxypseudooxynicotine + 1 H(2)O(2)." [] xref: EC:1.5.3.6 xref: GO:0018530 "molecular_function:(R)-6-hydroxynicotine oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC03043 ! (R)-6-hydroxynicotine relationship: has_input_compound UPa:UPC03043 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-6-hydroxynicotine relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC01297 ! 6-hydroxypseudooxynicotine relationship: has_output_compound UPa:UPC01297 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-hydroxypseudooxynicotine relationship: part_of UPa:ULS00231 {cardinality="1", order="2"} ! 6-hydroxypseudooxynicotine from nicotine (R-isomer route) relationship: part_of UPa:ULS00231 ! 6-hydroxypseudooxynicotine from nicotine (R-isomer route) [Term] id: UPa:UER00489 name: 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine: step 1/2 namespace: enzymatic_reaction def: "1 6-hydroxypseudooxynicotine + 1 H(2)O + 1 acceptor => 1 2,6-dihydroxypseudooxynicotine + 1 reduced acceptor." [] xref: EC:1.5.99.14 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC01297 ! 6-hydroxypseudooxynicotine relationship: has_input_compound UPa:UPC01297 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-hydroxypseudooxynicotine relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_output_compound UPa:UPC15986 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,6-dihydroxypseudooxynicotine relationship: has_output_compound UPa:UPC15986 ! 2,6-dihydroxypseudooxynicotine relationship: part_of UPa:ULS00454 {cardinality="1", order="1"} ! 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine relationship: part_of UPa:ULS00454 ! 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine [Term] id: UPa:UER00490 name: 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine: step 2/2 namespace: enzymatic_reaction def: "1 2,6-dihydroxypseudooxynicotine + 1 H(2)O => 1 2,6-dihydroxypyridine + 1 4-(methylamino)butanoate." [] xref: EC:3.7.1.19 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC15986 ! 2,6-dihydroxypseudooxynicotine relationship: has_input_compound UPa:UPC15986 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,6-dihydroxypseudooxynicotine relationship: has_output_compound UPa:UPC03056 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,6-dihydroxypyridine relationship: has_output_compound UPa:UPC03056 ! 2,6-dihydroxypyridine relationship: has_output_compound UPa:UPC15987 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-(methylamino)butanoate relationship: has_output_compound UPa:UPC15987 ! 4-(methylamino)butanoate relationship: part_of UPa:ULS00454 ! 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine relationship: part_of UPa:ULS00454 {cardinality="1", order="2"} ! 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine [Term] id: UPa:UER00491 name: UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 2 NAD(+) + 1 UDP-alpha-D-glucose => 2 H(+) + 2 NADH + 1 UDP-alpha-D-glucuronate." [] xref: EC:1.1.1.22 xref: GO:0003979 "molecular_function:UDP-glucose 6-dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00029 ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC00029 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-alpha-D-glucose relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00167 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate relationship: part_of UPa:ULS00234 ! UDP-alpha-D-glucuronate from UDP-alpha-D-glucose relationship: part_of UPa:ULS00234 {cardinality="1", order="1"} ! UDP-alpha-D-glucuronate from UDP-alpha-D-glucose [Term] id: UPa:UER00492 name: UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 1/3 namespace: enzymatic_reaction def: "1 NAD(+) + 1 UDP-alpha-D-glucuronate => 1 CO(2) + 1 H(+) + 1 NADH + 1 UDP-beta-L-threo-pentopyranos-4-ulose." [] xref: EC:1.1.1.305 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00167 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-alpha-D-glucuronate relationship: has_input_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC16155 ! UDP-beta-L-threo-pentopyranos-4-ulose relationship: has_output_compound UPa:UPC16155 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-beta-L-threo-pentopyranos-4-ulose relationship: part_of UPa:ULS00232 ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate relationship: part_of UPa:ULS00232 {cardinality="1", order="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate [Term] id: UPa:UER00493 name: UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 2/3 namespace: enzymatic_reaction def: "1 L-glutamate + 1 UDP-beta-L-threo-pentopyranos-4-ulose => 1 2-oxoglutarate + 1 UDP-4-amino-4-deoxy-L-arabinose." [] xref: EC:2.6.1.87 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC16155 ! UDP-beta-L-threo-pentopyranos-4-ulose relationship: has_input_compound UPa:UPC16155 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-beta-L-threo-pentopyranos-4-ulose relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC16153 ! UDP-4-amino-4-deoxy-L-arabinose relationship: has_output_compound UPa:UPC16153 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-4-amino-4-deoxy-L-arabinose relationship: part_of UPa:ULS00232 ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate relationship: part_of UPa:ULS00232 {cardinality="1", order="2"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate [Term] id: UPa:UER00494 name: UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 3/3 namespace: enzymatic_reaction def: "1 10-formyl-5,6,7,8-tetrahydrofolate + 1 UDP-4-amino-4-deoxy-L-arabinose => 1 5,6,7,8-tetrahydrofolate + 1 UDP-4-deoxy-4-formamido-beta-L-arabinose." [] xref: EC:2.1.2.13 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00234 {cardinality="1", is_alternate="False", is_primary="False"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00234 ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC16153 ! UDP-4-amino-4-deoxy-L-arabinose relationship: has_input_compound UPa:UPC16153 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-4-amino-4-deoxy-L-arabinose relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC16154 ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: has_output_compound UPa:UPC16154 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: part_of UPa:ULS00232 ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate relationship: part_of UPa:ULS00232 {cardinality="1", order="3"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate [Term] id: UPa:UER00495 name: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 1/2 namespace: enzymatic_reaction def: "1 UDP-4-deoxy-4-formamido-beta-L-arabinose + 1 di-trans,poly-cis-undecaprenyl phosphate => 1 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate + 1 UDP." [] xref: EC:2.4.2.53 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC16154 ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: has_input_compound UPa:UPC16154 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: has_input_compound UPa:UPC17556 ! di-trans,poly-cis-undecaprenyl phosphate relationship: has_input_compound UPa:UPC17556 {cardinality="1", is_alternate="False", is_primary="False"} ! di-trans,poly-cis-undecaprenyl phosphate relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00015 {cardinality="1", is_alternate="False", is_primary="False"} ! UDP relationship: has_output_compound UPa:UPC16156 ! 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate relationship: has_output_compound UPa:UPC16156 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate relationship: part_of UPa:ULS00233 ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate relationship: part_of UPa:ULS00233 {cardinality="1", order="1"} ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate [Term] id: UPa:UER00496 name: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2 namespace: enzymatic_reaction def: "1 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate + 1 H(2)O => 1 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate + 1 formate." [] xref: EC:3.5.1.n3 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC16156 ! 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate relationship: has_input_compound UPa:UPC16156 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC16157 ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate relationship: has_output_compound UPa:UPC16157 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate relationship: part_of UPa:ULS00233 ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate relationship: part_of UPa:ULS00233 {cardinality="1", order="2"} ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate [Term] id: UPa:UER00497 name: D-alanine from L-alanine: step 1/1 namespace: enzymatic_reaction def: "1 L-alanine => 1 D-alanine." [] xref: EC:5.1.1.1 xref: GO:0008784 "molecular_function:alanine racemase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00041 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alanine relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_output_compound UPa:UPC00133 {cardinality="1", is_alternate="False", is_primary="True"} ! D-alanine relationship: has_output_compound UPa:UPC00133 ! D-alanine relationship: part_of UPa:ULS00236 ! D-alanine from L-alanine relationship: part_of UPa:ULS00236 {cardinality="1", order="1"} ! D-alanine from L-alanine [Term] id: UPa:UER00498 name: NH(3) and pyruvate from D-alanine: step 1/1 namespace: enzymatic_reaction def: "1 D-alanine + 1 H(2)O + 1 acceptor => 1 NH(3) + 1 pyruvate + 1 reduced acceptor." [] xref: EC:1.4.99.1 xref: GO:0008718 "molecular_function:D-amino-acid dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_input_compound UPa:UPC00133 {cardinality="1", is_alternate="False", is_primary="True"} ! D-alanine relationship: has_input_compound UPa:UPC00133 ! D-alanine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="True"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: part_of UPa:ULS00237 ! NH(3) and pyruvate from D-alanine relationship: part_of UPa:ULS00237 {cardinality="1", order="1"} ! NH(3) and pyruvate from D-alanine [Term] id: UPa:UER00499 name: cyanurate from atrazine: step 1/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 atrazine => 1 HCl + 1 hydroxyatrazine." [] xref: EC:3.8.1.8 xref: GO:0018788 "molecular_function:atrazine chlorohydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC06551 ! atrazine relationship: has_input_compound UPa:UPC06551 {cardinality="1", is_alternate="False", is_primary="True"} ! atrazine relationship: has_output_compound UPa:UPC01327 ! HCl relationship: has_output_compound UPa:UPC01327 {cardinality="1", is_alternate="False", is_primary="False"} ! HCl relationship: has_output_compound UPa:UPC06552 ! hydroxyatrazine relationship: has_output_compound UPa:UPC06552 {cardinality="1", is_alternate="False", is_primary="True"} ! hydroxyatrazine relationship: part_of UPa:ULS00238 ! cyanurate from atrazine relationship: part_of UPa:ULS00238 {cardinality="1", order="1"} ! cyanurate from atrazine [Term] id: UPa:UER00500 name: cyanurate from atrazine: step 2/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 hydroxyatrazine => 1 N-isopropylammelide + 1 ethylamine." [] xref: EC:3.5.99.3 xref: GO:0018763 "molecular_function:hydroxydechloroatrazine ethylaminohydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC06552 ! hydroxyatrazine relationship: has_input_compound UPa:UPC06552 {cardinality="1", is_alternate="False", is_primary="True"} ! hydroxyatrazine relationship: has_output_compound UPa:UPC00797 {cardinality="1", is_alternate="False", is_primary="False"} ! ethylamine relationship: has_output_compound UPa:UPC00797 ! ethylamine relationship: has_output_compound UPa:UPC06553 ! N-isopropylammelide relationship: has_output_compound UPa:UPC06553 {cardinality="1", is_alternate="False", is_primary="True"} ! N-isopropylammelide relationship: part_of UPa:ULS00238 ! cyanurate from atrazine relationship: part_of UPa:ULS00238 {cardinality="1", order="2"} ! cyanurate from atrazine [Term] id: UPa:UER00501 name: cyanurate from atrazine: step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-isopropylammelide => 1 cyanurate + 1 isopropylamine." [] xref: EC:3.5.99.4 xref: GO:0018764 "molecular_function:N-isopropylammelide isopropylaminohydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC06553 ! N-isopropylammelide relationship: has_input_compound UPa:UPC06553 {cardinality="1", is_alternate="False", is_primary="True"} ! N-isopropylammelide relationship: has_output_compound UPa:UPC06554 ! cyanurate relationship: has_output_compound UPa:UPC06554 {cardinality="1", is_alternate="False", is_primary="True"} ! cyanurate relationship: has_output_compound UPa:UPC06748 ! isopropylamine relationship: has_output_compound UPa:UPC06748 {cardinality="1", is_alternate="False", is_primary="False"} ! isopropylamine relationship: part_of UPa:ULS00238 ! cyanurate from atrazine relationship: part_of UPa:ULS00238 {cardinality="1", order="3"} ! cyanurate from atrazine [Term] id: UPa:UER00502 name: biuret from cyanurate: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 cyanurate => 1 CO(2) + 1 biuret." [] xref: EC:3.5.2.15 xref: GO:0018753 "molecular_function:cyanuric acid amidohydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC06554 ! cyanurate relationship: has_input_compound UPa:UPC06554 {cardinality="1", is_alternate="False", is_primary="True"} ! cyanurate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC06555 ! biuret relationship: has_output_compound UPa:UPC06555 {cardinality="1", is_alternate="False", is_primary="True"} ! biuret relationship: part_of UPa:ULS00239 ! biuret from cyanurate relationship: part_of UPa:ULS00239 {cardinality="1", order="1"} ! biuret from cyanurate [Term] id: UPa:UER00503 name: phosphatidylglycerol from CDP-diacylglycerol: step 1/2 namespace: enzymatic_reaction def: "1 CDP-diacylglycerol + 1 sn-glycerol 3-phosphate => 1 CMP + 1 phosphatidylglycerophosphate." [] xref: EC:2.7.8.5 xref: GO:0008444 "molecular_function:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00093 {cardinality="1", is_alternate="False", is_primary="False"} ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: has_input_compound UPa:UPC00269 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="False"} ! CMP relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC03892 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphatidylglycerophosphate relationship: has_output_compound UPa:UPC03892 ! phosphatidylglycerophosphate relationship: part_of UPa:ULS00240 ! phosphatidylglycerol from CDP-diacylglycerol relationship: part_of UPa:ULS00240 {cardinality="1", order="1"} ! phosphatidylglycerol from CDP-diacylglycerol [Term] id: UPa:UER00504 name: phosphatidylglycerol from CDP-diacylglycerol: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 phosphatidylglycerophosphate => 1 phosphate + 1 phosphatidylglycerol." [] xref: EC:3.1.3.27 xref: GO:0008962 "molecular_function:phosphatidylglycerophosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC03892 ! phosphatidylglycerophosphate relationship: has_input_compound UPa:UPC03892 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphatidylglycerophosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00344 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphatidylglycerol relationship: has_output_compound UPa:UPC00344 ! phosphatidylglycerol relationship: part_of UPa:ULS00240 ! phosphatidylglycerol from CDP-diacylglycerol relationship: part_of UPa:ULS00240 {cardinality="1", order="2"} ! phosphatidylglycerol from CDP-diacylglycerol [Term] id: UPa:UER00505 name: glycine from L-threonine: step 1/2 namespace: enzymatic_reaction def: "1 L-threonine + 1 NAD(+) => 1 H(+) + 1 L-2-amino-3-oxobutanoic acid + 1 NADH." [] xref: EC:1.1.1.103 xref: GO:0008743 "molecular_function:L-threonine 3-dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00188 {cardinality="1", is_alternate="False", is_primary="True"} ! L-threonine relationship: has_input_compound UPa:UPC00188 ! L-threonine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC03508 ! L-2-amino-3-oxobutanoic acid relationship: has_output_compound UPa:UPC03508 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-amino-3-oxobutanoic acid relationship: part_of UPa:ULS00241 ! glycine from L-threonine relationship: part_of UPa:ULS00241 {cardinality="1", order="1"} ! glycine from L-threonine [Term] id: UPa:UER00506 name: glycine from L-threonine: step 2/2 namespace: enzymatic_reaction def: "1 CoA + 1 L-2-amino-3-oxobutanoic acid => 1 acetyl-CoA + 1 glycine." [] xref: EC:2.3.1.29 xref: GO:0008890 "molecular_function:glycine C-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC03508 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-amino-3-oxobutanoic acid relationship: has_input_compound UPa:UPC03508 ! L-2-amino-3-oxobutanoic acid relationship: has_output_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="True"} ! glycine relationship: has_output_compound UPa:UPC00037 ! glycine relationship: part_of UPa:ULS00241 ! glycine from L-threonine relationship: part_of UPa:ULS00241 {cardinality="1", order="2"} ! glycine from L-threonine [Term] id: UPa:UER00507 name: propanoate from L-threonine: step 1/4 namespace: enzymatic_reaction def: "1 L-threonine => 1 2-oxobutanoate + 1 NH(3)." [] xref: EC:4.3.1.19 xref: GO:0004794 "molecular_function:L-threonine ammonia-lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00188 {cardinality="1", is_alternate="False", is_primary="True"} ! L-threonine relationship: has_input_compound UPa:UPC00188 ! L-threonine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00109 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00109 ! 2-oxobutanoate relationship: part_of UPa:ULS00242 ! propanoate from L-threonine relationship: part_of UPa:ULS00242 {cardinality="1", order="1"} ! propanoate from L-threonine [Term] id: UPa:UER00508 name: propanoate from L-threonine: step 2/4 namespace: enzymatic_reaction def: "1 2-oxobutanoate + 1 CoA => 1 formate + 1 propanoyl-CoA." [] xref: EC:2.3.1 xref: GO:0004147 "molecular_function:dihydrolipoamide branched chain acyltransferase activity" xref: GO:0004772 "molecular_function:sterol O-acyltransferase activity" xref: GO:0008080 "molecular_function:N-acetyltransferase activity" xref: GO:0008374 "molecular_function:O-acyltransferase activity" xref: GO:0008951 "molecular_function:palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity" xref: GO:0016406 "molecular_function:carnitine O-acyltransferase activity" xref: GO:0016407 "molecular_function:acetyltransferase activity" xref: GO:0016408 "molecular_function:C-acyltransferase activity" xref: GO:0016409 "molecular_function:palmitoyltransferase activity" xref: GO:0016410 "molecular_function:N-acyltransferase activity" xref: GO:0016411 "molecular_function:acylglycerol O-acyltransferase activity" xref: GO:0016412 "molecular_function:serine O-acyltransferase activity" xref: GO:0016413 "molecular_function:O-acetyltransferase activity" xref: GO:0016414 "molecular_function:O-octanoyltransferase activity" xref: GO:0016415 "molecular_function:octanoyltransferase activity" xref: GO:0016416 "molecular_function:O-palmitoyltransferase activity" xref: GO:0016417 "molecular_function:S-acyltransferase activity" xref: GO:0016418 "molecular_function:S-acetyltransferase activity" xref: GO:0016419 "molecular_function:S-malonyltransferase activity" xref: GO:0016420 "molecular_function:malonyltransferase activity" xref: GO:0016454 "molecular_function:C-palmitoyltransferase activity" xref: GO:0016747 "molecular_function:transferase activity, transferring acyl groups other than amino-acyl groups" xref: GO:0016748 "molecular_function:succinyltransferase activity" xref: GO:0016749 "molecular_function:N-succinyltransferase activity" xref: GO:0016750 "molecular_function:O-succinyltransferase activity" xref: GO:0016751 "molecular_function:S-succinyltransferase activity" xref: GO:0016752 "molecular_function:sinapoyltransferase activity" xref: GO:0016753 "molecular_function:O-sinapoyltransferase activity" xref: GO:0018030 "molecular_function:peptidyl-lysine N6-myristoyltransferase activity" xref: GO:0018031 "molecular_function:peptidyl-lysine N6-palmitoyltransferase activity" xref: GO:0018711 "molecular_function:benzoyl acetate-CoA thiolase activity" xref: GO:0018712 "molecular_function:3-hydroxybutyryl-CoA thiolase activity" xref: GO:0018713 "molecular_function:3-ketopimelyl-CoA thiolase activity" xref: GO:0019105 "molecular_function:N-palmitoyltransferase activity" xref: GO:0019107 "molecular_function:myristoyltransferase activity" xref: GO:0019186 "molecular_function:acyl-CoA N-acyltransferase activity" xref: GO:0019705 "molecular_function:protein-cysteine S-myristoyltransferase activity" xref: GO:0019707 "molecular_function:protein-cysteine S-acyltransferase activity" xref: GO:0030523 "molecular_function:dihydrolipoamide S-acyltransferase activity" xref: GO:0032216 "molecular_function:glucosaminyl-phosphotidylinositol O-acyltransferase activity" xref: GO:0034737 "molecular_function:ergosterol O-acyltransferase activity" xref: GO:0034738 "molecular_function:lanosterol O-acyltransferase activity" xref: GO:0034848 "molecular_function:naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity" xref: GO:0034851 "molecular_function:2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity" xref: GO:0034915 "molecular_function:2-methylhexanoyl-CoA C-acetyltransferase activity" xref: GO:0034919 "molecular_function:butyryl-CoA 2-C-propionyltransferase activity" xref: GO:0034945 "molecular_function:2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity" xref: GO:0043741 "molecular_function:L-2-aminoadipate N-acetyltransferase activity" xref: GO:0043764 "molecular_function:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity" xref: GO:0043806 "molecular_function:keto acid formate lyase activity" xref: GO:0043849 "molecular_function:Ras palmitoyltransferase activity" xref: GO:0043875 "molecular_function:2-ketobutyrate formate-lyase activity" xref: GO:0046941 "molecular_function:azetidine-2-carboxylic acid acetyltransferase activity" xref: GO:0052858 "molecular_function:peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor" xref: GO:0090595 "molecular_function:acetyl-CoA:L-lysine N6-acetyltransferase" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00109 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxobutanoate relationship: has_input_compound UPa:UPC00109 ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00100 {cardinality="1", is_alternate="False", is_primary="True"} ! propanoyl-CoA relationship: has_output_compound UPa:UPC00100 ! propanoyl-CoA relationship: part_of UPa:ULS00242 ! propanoate from L-threonine relationship: part_of UPa:ULS00242 {cardinality="1", order="2"} ! propanoate from L-threonine [Term] id: UPa:UER00509 name: propanoate from L-threonine: step 3/4 namespace: enzymatic_reaction def: "1 phosphate + 1 propanoyl-CoA => 1 CoA + 1 propanoyl phosphate." [] xref: EC:2.3.1.222 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_input_compound UPa:UPC00100 {cardinality="1", is_alternate="False", is_primary="True"} ! propanoyl-CoA relationship: has_input_compound UPa:UPC00100 ! propanoyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC02876 ! propanoyl phosphate relationship: has_output_compound UPa:UPC02876 {cardinality="1", is_alternate="False", is_primary="True"} ! propanoyl phosphate relationship: part_of UPa:ULS00242 ! propanoate from L-threonine relationship: part_of UPa:ULS00242 {cardinality="1", order="3"} ! propanoate from L-threonine [Term] id: UPa:UER00510 name: propanoate from L-threonine: step 4/4 namespace: enzymatic_reaction def: "1 ADP + 1 propanoyl phosphate => 1 ATP + 1 propanoate." [] xref: EC:2.7.2.15 xref: GO:0008980 "molecular_function:propionate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_input_compound UPa:UPC00008 ! ADP relationship: has_input_compound UPa:UPC02876 ! propanoyl phosphate relationship: has_input_compound UPa:UPC02876 {cardinality="1", is_alternate="False", is_primary="True"} ! propanoyl phosphate relationship: has_output_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_output_compound UPa:UPC00002 ! ATP relationship: has_output_compound UPa:UPC00163 ! propanoate relationship: has_output_compound UPa:UPC00163 {cardinality="1", is_alternate="False", is_primary="True"} ! propanoate relationship: part_of UPa:ULS00242 {cardinality="1", order="4"} ! propanoate from L-threonine relationship: part_of UPa:ULS00242 ! propanoate from L-threonine [Term] id: UPa:UER00511 name: CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 1/5 namespace: enzymatic_reaction def: "1 CTP + 1 alpha-D-glucose 1-phosphate => 1 CDP-glucose + 1 diphosphate." [] xref: EC:2.7.7.33 xref: GO:0047343 "molecular_function:glucose-1-phosphate cytidylyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00063 {cardinality="1", is_alternate="False", is_primary="True"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00103 ! alpha-D-glucose 1-phosphate relationship: has_input_compound UPa:UPC00103 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-glucose 1-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00501 ! CDP-glucose relationship: has_output_compound UPa:UPC00501 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-glucose relationship: part_of UPa:ULS00243 {cardinality="1", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate relationship: part_of UPa:ULS00243 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate [Term] id: UPa:UER00512 name: CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 2/5 namespace: enzymatic_reaction def: "1 CDP-glucose => 1 CDP-4-dehydro-6-deoxy-D-glucose + 1 H(2)O." [] xref: EC:4.2.1.45 xref: GO:0047733 "molecular_function:CDP-glucose 4,6-dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00501 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-glucose relationship: has_input_compound UPa:UPC00501 ! CDP-glucose relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC01219 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-4-dehydro-6-deoxy-D-glucose relationship: has_output_compound UPa:UPC01219 ! CDP-4-dehydro-6-deoxy-D-glucose relationship: part_of UPa:ULS00243 {cardinality="1", order="2"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate relationship: part_of UPa:ULS00243 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate [Term] id: UPa:UER00513 name: CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 3/5 namespace: enzymatic_reaction def: "CDP-4-dehydro-6-deoxy-D-glucose + H(+) + [NADH or NADPH] => CDP-4-dehydro-3,6-dideoxy-D-glucose + H(2)O + [NAD(+) or NADP(+)]." [] xref: EC:1.17.1.1 xref: GO:0047099 "molecular_function:CDP-4-dehydro-6-deoxyglucose reductase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00967 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00968 ! None relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01219 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-4-dehydro-6-deoxy-D-glucose relationship: has_input_compound UPa:UPC01219 ! CDP-4-dehydro-6-deoxy-D-glucose relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC04297 ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC04297 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: part_of UPa:ULS00243 {cardinality="1", order="3"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate relationship: part_of UPa:ULS00243 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate [Term] id: UPa:UER00514 name: CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 4/5 namespace: enzymatic_reaction def: "1 CDP-4-dehydro-3,6-dideoxy-D-glucose + 1 H(+) + 1 NADPH => 1 CDP-3,6-dideoxy-D-glucose + 1 NADP(+)." [] xref: EC:1.1.1.342 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC04297 ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: has_input_compound UPa:UPC04297 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC03598 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC03598 ! CDP-3,6-dideoxy-D-glucose relationship: part_of UPa:ULS00243 {cardinality="1", order="4"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate relationship: part_of UPa:ULS00243 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate [Term] id: UPa:UER00515 name: CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 5/5 namespace: enzymatic_reaction def: "1 CDP-3,6-dideoxy-D-glucose => 1 CDP-3,6-dideoxy-D-mannose." [] xref: EC:5.1.3.10 xref: GO:0047732 "molecular_function:CDP-abequose epimerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03598 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-3,6-dideoxy-D-glucose relationship: has_input_compound UPa:UPC03598 ! CDP-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC03599 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-3,6-dideoxy-D-mannose relationship: has_output_compound UPa:UPC03599 ! CDP-3,6-dideoxy-D-mannose relationship: part_of UPa:ULS00243 {cardinality="1", order="5"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate relationship: part_of UPa:ULS00243 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate [Term] id: UPa:UER00516 name: alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2 namespace: enzymatic_reaction def: "1 5,6-dimethylbenzimidazole + 1 nicotinate D-ribonucleotide => 1 H(+) + 1 alpha-ribazole 5'-phosphate + 1 nicotinate." [] xref: EC:2.4.2.21 xref: GO:0008939 "molecular_function:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01185 {cardinality="1", is_alternate="False", is_primary="False"} ! nicotinate D-ribonucleotide relationship: has_input_compound UPa:UPC01185 ! nicotinate D-ribonucleotide relationship: has_input_compound UPa:UPC03114 ! 5,6-dimethylbenzimidazole relationship: has_input_compound UPa:UPC03114 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,6-dimethylbenzimidazole relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00253 {cardinality="1", is_alternate="False", is_primary="False"} ! nicotinate relationship: has_output_compound UPa:UPC00253 ! nicotinate relationship: has_output_compound UPa:UPC04778 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-ribazole 5'-phosphate relationship: has_output_compound UPa:UPC04778 ! alpha-ribazole 5'-phosphate relationship: part_of UPa:ULS00244 {cardinality="1", order="1"} ! alpha-ribazole from 5,6-dimethylbenzimidazole relationship: part_of UPa:ULS00244 ! alpha-ribazole from 5,6-dimethylbenzimidazole [Term] id: UPa:UER00517 name: alpha-ribazole from 5,6-dimethylbenzimidazole: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 alpha-ribazole 5'-phosphate => 1 alpha-ribazole + 1 phosphate." [] xref: EC:3.1.3.73 xref: GO:0043755 "molecular_function:alpha-ribazole phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04778 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-ribazole 5'-phosphate relationship: has_input_compound UPa:UPC04778 ! alpha-ribazole 5'-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC05775 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-ribazole relationship: has_output_compound UPa:UPC05775 ! alpha-ribazole relationship: part_of UPa:ULS00244 {cardinality="1", order="2"} ! alpha-ribazole from 5,6-dimethylbenzimidazole relationship: part_of UPa:ULS00244 ! alpha-ribazole from 5,6-dimethylbenzimidazole [Term] id: UPa:UER00518 name: D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3 namespace: enzymatic_reaction def: "1 D-galactonate => 1 2-dehydro-3-deoxy-D-galactonate + 1 H(2)O." [] xref: EC:4.2.1.6 xref: GO:0008869 "molecular_function:galactonate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00880 ! D-galactonate relationship: has_input_compound UPa:UPC00880 {cardinality="1", is_alternate="False", is_primary="True"} ! D-galactonate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC01216 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydro-3-deoxy-D-galactonate relationship: has_output_compound UPa:UPC01216 ! 2-dehydro-3-deoxy-D-galactonate relationship: part_of UPa:ULS00245 {cardinality="1", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate relationship: part_of UPa:ULS00245 ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate [Term] id: UPa:UER00519 name: D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 2/3 namespace: enzymatic_reaction def: "1 2-dehydro-3-deoxy-D-galactonate + 1 ATP => 1 6-phospho-2-dehydro-3-deoxy-D-galactonic acid + 1 ADP." [] xref: EC:2.7.1.58 xref: GO:0008671 "molecular_function:2-dehydro-3-deoxygalactonokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01216 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydro-3-deoxy-D-galactonate relationship: has_input_compound UPa:UPC01216 ! 2-dehydro-3-deoxy-D-galactonate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC01286 ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid relationship: has_output_compound UPa:UPC01286 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid relationship: part_of UPa:ULS00245 {cardinality="1", order="2"} ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate relationship: part_of UPa:ULS00245 ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate [Term] id: UPa:UER00520 name: D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 3/3 namespace: enzymatic_reaction def: "1 6-phospho-2-dehydro-3-deoxy-D-galactonic acid => 1 D-glyceraldehyde 3-phosphate + 1 pyruvate." [] xref: EC:4.1.2.21 xref: GO:0008674 "molecular_function:2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01286 ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid relationship: has_input_compound UPa:UPC01286 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00245 ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate relationship: part_of UPa:ULS00245 {cardinality="1", order="3"} ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate [Term] id: UPa:UER00521 name: vindoline from tabersonine: step 1/6 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 O(2) + 1 tabersonine => 1 16-hydroxytabersonine + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.73 xref: GO:0050594 "molecular_function:tabersonine 16-hydroxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC09244 {cardinality="1", is_alternate="False", is_primary="True"} ! tabersonine relationship: has_input_compound UPa:UPC09244 ! tabersonine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC11643 ! 16-hydroxytabersonine relationship: has_output_compound UPa:UPC11643 {cardinality="1", is_alternate="False", is_primary="True"} ! 16-hydroxytabersonine relationship: part_of UPa:ULS00246 ! vindoline from tabersonine relationship: part_of UPa:ULS00246 {cardinality="1", order="1"} ! vindoline from tabersonine [Term] id: UPa:UER00522 name: vindoline from tabersonine: step 2/6 namespace: enzymatic_reaction def: "1 16-hydroxytabersonine + 1 S-adenosyl-L-methionine => 1 16-methoxytabersonine + 1 H(+) + 1 S-adenosyl-L-homocysteine." [] xref: EC:2.1.1.94 xref: GO:0030766 "molecular_function:11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11643 {cardinality="1", is_alternate="False", is_primary="True"} ! 16-hydroxytabersonine relationship: has_input_compound UPa:UPC11643 ! 16-hydroxytabersonine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC11675 ! 16-methoxytabersonine relationship: has_output_compound UPa:UPC11675 {cardinality="1", is_alternate="False", is_primary="True"} ! 16-methoxytabersonine relationship: part_of UPa:ULS00246 ! vindoline from tabersonine relationship: part_of UPa:ULS00246 {cardinality="1", order="2"} ! vindoline from tabersonine [Term] id: UPa:UER00523 name: vindoline from tabersonine: step 3/6 namespace: enzymatic_reaction def: "1 16-methoxytabersonine + 1 H(2)O => 1 3-hydroxy-16-methoxy-2,3-dihydrotabersonine." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC11675 {cardinality="1", is_alternate="False", is_primary="True"} ! 16-methoxytabersonine relationship: has_input_compound UPa:UPC11675 ! 16-methoxytabersonine relationship: has_output_compound UPa:UPC04578 ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine relationship: has_output_compound UPa:UPC04578 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine relationship: part_of UPa:ULS00246 ! vindoline from tabersonine relationship: part_of UPa:ULS00246 {cardinality="1", order="3"} ! vindoline from tabersonine [Term] id: UPa:UER00524 name: vindoline from tabersonine: step 4/6 namespace: enzymatic_reaction def: "1 3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 1 S-adenosyl-L-methionine => 1 S-adenosyl-L-homocysteine + 1 desacetoxyvindoline." [] xref: EC:2.1.1.99 xref: GO:0030768 "molecular_function:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC04578 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine relationship: has_input_compound UPa:UPC04578 ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC02673 ! desacetoxyvindoline relationship: has_output_compound UPa:UPC02673 {cardinality="1", is_alternate="False", is_primary="True"} ! desacetoxyvindoline relationship: part_of UPa:ULS00246 ! vindoline from tabersonine relationship: part_of UPa:ULS00246 {cardinality="1", order="4"} ! vindoline from tabersonine [Term] id: UPa:UER00525 name: vindoline from tabersonine: step 5/6 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 O(2) + 1 desacetoxyvindoline => 1 CO(2) + 1 deacetylvindoline + 1 succinate." [] xref: EC:1.14.11.20 xref: GO:0050590 "molecular_function:desacetoxyvindoline 4-hydroxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC02673 ! desacetoxyvindoline relationship: has_input_compound UPa:UPC02673 {cardinality="1", is_alternate="False", is_primary="True"} ! desacetoxyvindoline relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC01091 {cardinality="1", is_alternate="False", is_primary="True"} ! deacetylvindoline relationship: has_output_compound UPa:UPC01091 ! deacetylvindoline relationship: part_of UPa:ULS00246 ! vindoline from tabersonine relationship: part_of UPa:ULS00246 {cardinality="1", order="5"} ! vindoline from tabersonine [Term] id: UPa:UER00526 name: vindoline from tabersonine: step 6/6 namespace: enzymatic_reaction def: "1 acetyl-CoA + 1 deacetylvindoline => 1 CoA + 1 vindoline." [] xref: EC:2.3.1.107 xref: GO:0047162 "molecular_function:17-O-deacetylvindoline O-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC01091 {cardinality="1", is_alternate="False", is_primary="True"} ! deacetylvindoline relationship: has_input_compound UPa:UPC01091 ! deacetylvindoline relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC01626 ! vindoline relationship: has_output_compound UPa:UPC01626 {cardinality="1", is_alternate="False", is_primary="True"} ! vindoline relationship: part_of UPa:ULS00246 ! vindoline from tabersonine relationship: part_of UPa:ULS00246 {cardinality="1", order="6"} ! vindoline from tabersonine [Term] id: UPa:UER00527 name: D-glucuronate from myo-inositol: step 1/1 namespace: enzymatic_reaction def: "1 O(2) + 1 myo-inositol => 1 D-glucuronate + 1 H(2)O." [] xref: EC:1.13.99.1 xref: GO:0050113 "molecular_function:inositol oxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00137 ! myo-inositol relationship: has_input_compound UPa:UPC00137 {cardinality="1", is_alternate="False", is_primary="True"} ! myo-inositol relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00191 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucuronate relationship: has_output_compound UPa:UPC00191 ! D-glucuronate relationship: part_of UPa:ULS00069 ! D-glucuronate from myo-inositol relationship: part_of UPa:ULS00069 {cardinality="1", order="1"} ! D-glucuronate from myo-inositol [Term] id: UPa:UER00528 name: alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 D-fructose 6-phosphate + 1 L-glutamine => 1 L-glutamate + 1 alpha-D-glucosamine 6-phosphate." [] xref: EC:2.6.1.16 xref: GO:0004360 "molecular_function:glutamine-fructose-6-phosphate transaminase (isomerizing) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00085 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00352 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: part_of UPa:ULS00247 ! alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate relationship: part_of UPa:ULS00247 {cardinality="1", order="1"} ! alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate [Term] id: UPa:UER00529 name: N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2 namespace: enzymatic_reaction def: "1 acetyl-CoA + 1 alpha-D-glucosamine 6-phosphate => 1 CoA + 1 N-acetyl-D-glucosamine 6-phosphate." [] xref: EC:2.3.1.4 xref: GO:0004343 "molecular_function:glucosamine 6-phosphate N-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: has_input_compound UPa:UPC00352 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00357 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00357 ! N-acetyl-D-glucosamine 6-phosphate relationship: part_of UPa:ULS00248 ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I) relationship: part_of UPa:ULS00248 {cardinality="1", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I) [Term] id: UPa:UER00530 name: N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2 namespace: enzymatic_reaction def: "1 N-acetyl-D-glucosamine 6-phosphate => 1 N-acetyl-alpha-D-glucosamine 1-phosphate." [] xref: EC:5.4.2.3 xref: GO:0004610 "molecular_function:phosphoacetylglucosamine mutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00357 ! N-acetyl-D-glucosamine 6-phosphate relationship: has_input_compound UPa:UPC00357 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC04501 ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC04501 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: part_of UPa:ULS00248 {cardinality="1", order="2"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I) relationship: part_of UPa:ULS00248 ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I) [Term] id: UPa:UER00531 name: N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 1/2 namespace: enzymatic_reaction def: "1 alpha-D-glucosamine 6-phosphate => 1 alpha-D-glucosamine 1-phosphate." [] xref: EC:5.4.2.10 xref: GO:0008966 "molecular_function:phosphoglucosamine mutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: has_input_compound UPa:UPC00352 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC06156 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC06156 ! alpha-D-glucosamine 1-phosphate relationship: part_of UPa:ULS00249 {cardinality="1", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II) relationship: part_of UPa:ULS00249 ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II) [Term] id: UPa:UER00532 name: N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2 namespace: enzymatic_reaction def: "1 acetyl-CoA + 1 alpha-D-glucosamine 1-phosphate => 1 CoA + 1 N-acetyl-alpha-D-glucosamine 1-phosphate." [] xref: EC:2.3.1.157 xref: GO:0019134 "molecular_function:glucosamine-1-phosphate N-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC06156 ! alpha-D-glucosamine 1-phosphate relationship: has_input_compound UPa:UPC06156 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC04501 ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC04501 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: part_of UPa:ULS00249 {cardinality="1", order="2"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II) relationship: part_of UPa:ULS00249 ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II) [Term] id: UPa:UER00533 name: UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 N-acetyl-alpha-D-glucosamine 1-phosphate + 1 UTP => 1 UDP-N-acetyl-alpha-D-glucosamine + 1 diphosphate." [] xref: EC:2.7.7.23 xref: GO:0003977 "molecular_function:UDP-N-acetylglucosamine diphosphorylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00075 {cardinality="1", is_alternate="False", is_primary="False"} ! UTP relationship: has_input_compound UPa:UPC00075 ! UTP relationship: has_input_compound UPa:UPC04501 ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_input_compound UPa:UPC04501 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00043 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-N-acetyl-alpha-D-glucosamine relationship: has_output_compound UPa:UPC00043 ! UDP-N-acetyl-alpha-D-glucosamine relationship: part_of UPa:ULS00250 {cardinality="1", order="1"} ! UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate relationship: part_of UPa:ULS00250 ! UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate [Term] id: UPa:UER00535 name: D-glucose from alpha,alpha-trehalose: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 alpha,alpha-trehalose => 2 D-glucose." [] xref: EC:3.2.1.28 xref: GO:0004555 "molecular_function:alpha,alpha-trehalase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01083 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha,alpha-trehalose relationship: has_input_compound UPa:UPC01083 ! alpha,alpha-trehalose relationship: has_output_compound UPa:UPC00031 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucose relationship: has_output_compound UPa:UPC00031 ! D-glucose relationship: part_of UPa:ULS00251 {cardinality="1", order="1"} ! D-glucose from alpha,alpha-trehalose relationship: part_of UPa:ULS00251 ! D-glucose from alpha,alpha-trehalose [Term] id: UPa:UER00536 name: hypotaurine from 2-aminoethanethiol: step 1/1 namespace: enzymatic_reaction def: "1 2-aminoethanethiol + 1 O(2) => 1 hypotaurine." [] xref: EC:1.13.11.19 xref: GO:0047800 "molecular_function:cysteamine dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC01678 ! 2-aminoethanethiol relationship: has_input_compound UPa:UPC01678 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-aminoethanethiol relationship: has_output_compound UPa:UPC00519 ! hypotaurine relationship: has_output_compound UPa:UPC00519 {cardinality="1", is_alternate="False", is_primary="True"} ! hypotaurine relationship: part_of UPa:ULS00252 {cardinality="1", order="1"} ! hypotaurine from 2-aminoethanethiol relationship: part_of UPa:ULS00252 ! hypotaurine from 2-aminoethanethiol [Term] id: UPa:UER00537 name: hypotaurine from L-cysteine: step 1/2 namespace: enzymatic_reaction def: "1 L-cysteine + 1 O(2) => 1 3-sulfino-L-alanine." [] xref: EC:1.13.11.20 xref: GO:0017172 "molecular_function:cysteine dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cysteine relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_output_compound UPa:UPC00606 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-sulfino-L-alanine relationship: has_output_compound UPa:UPC00606 ! 3-sulfino-L-alanine relationship: part_of UPa:ULS00253 {cardinality="1", order="1"} ! hypotaurine from L-cysteine relationship: part_of UPa:ULS00253 ! hypotaurine from L-cysteine [Term] id: UPa:UER00538 name: hypotaurine from L-cysteine: step 2/2 namespace: enzymatic_reaction def: "1 3-sulfino-L-alanine => 1 CO(2) + 1 hypotaurine." [] xref: EC:4.1.1.29 xref: GO:0004782 "molecular_function:sulfinoalanine decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00606 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-sulfino-L-alanine relationship: has_input_compound UPa:UPC00606 ! 3-sulfino-L-alanine relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00519 ! hypotaurine relationship: has_output_compound UPa:UPC00519 {cardinality="1", is_alternate="False", is_primary="True"} ! hypotaurine relationship: part_of UPa:ULS00253 {cardinality="1", order="2"} ! hypotaurine from L-cysteine relationship: part_of UPa:ULS00253 ! hypotaurine from L-cysteine [Term] id: UPa:UER00539 name: taurine from hypotaurine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 hypotaurine => 1 H(+) + 1 NADH + 1 taurine." [] xref: EC:1.8.1.3 xref: GO:0047822 "molecular_function:hypotaurine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00519 ! hypotaurine relationship: has_input_compound UPa:UPC00519 {cardinality="1", is_alternate="False", is_primary="True"} ! hypotaurine relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00245 {cardinality="1", is_alternate="False", is_primary="True"} ! taurine relationship: has_output_compound UPa:UPC00245 ! taurine relationship: part_of UPa:ULS00254 {cardinality="1", order="1"} ! taurine from hypotaurine relationship: part_of UPa:ULS00254 ! taurine from hypotaurine [Term] id: UPa:UER00540 name: taurine from L-cysteine: step 1/2 namespace: enzymatic_reaction def: "1 L-cysteine + 1 sulfite => 1 L-cysteate + 1 hydrogen sulfide." [] xref: EC:4.4.1.10 xref: GO:0047803 "molecular_function:cysteine lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00094 ! sulfite relationship: has_input_compound UPa:UPC00094 {cardinality="1", is_alternate="False", is_primary="False"} ! sulfite relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cysteine relationship: has_output_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_output_compound UPa:UPC00283 {cardinality="1", is_alternate="False", is_primary="False"} ! hydrogen sulfide relationship: has_output_compound UPa:UPC00506 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cysteate relationship: has_output_compound UPa:UPC00506 ! L-cysteate relationship: part_of UPa:ULS00255 {cardinality="1", order="1"} ! taurine from L-cysteine relationship: part_of UPa:ULS00255 ! taurine from L-cysteine [Term] id: UPa:UER00541 name: taurine from L-cysteine: step 2/2 namespace: enzymatic_reaction def: "1 L-cysteate => 1 CO(2) + 1 taurine." [] xref: EC:4.1.1.29 xref: GO:0004782 "molecular_function:sulfinoalanine decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00506 ! L-cysteate relationship: has_input_compound UPa:UPC00506 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cysteate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00245 ! taurine relationship: has_output_compound UPa:UPC00245 {cardinality="1", is_alternate="False", is_primary="True"} ! taurine relationship: part_of UPa:ULS00255 ! taurine from L-cysteine relationship: part_of UPa:ULS00255 {cardinality="1", order="2"} ! taurine from L-cysteine [Term] id: UPa:UER00542 name: aminoacetaldehyde and sulfite from taurine: step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 O(2) + 1 taurine => 1 CO(2) + 1 aminoacetaldehyde + 1 succinate + 1 sulfite." [] xref: EC:1.14.11.17 xref: GO:0000908 "molecular_function:taurine dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00245 ! taurine relationship: has_input_compound UPa:UPC00245 {cardinality="1", is_alternate="False", is_primary="True"} ! taurine relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC00094 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfite relationship: has_output_compound UPa:UPC06735 ! aminoacetaldehyde relationship: has_output_compound UPa:UPC06735 {cardinality="1", is_alternate="False", is_primary="True"} ! aminoacetaldehyde relationship: part_of UPa:ULS00256 ! aminoacetaldehyde and sulfite from taurine relationship: part_of UPa:ULS00256 {cardinality="1", order="1"} ! aminoacetaldehyde and sulfite from taurine [Term] id: UPa:UER00543 name: acetyl phosphate and sulfite from taurine: step 1/2 namespace: enzymatic_reaction def: "1 pyruvate + 1 taurine => 1 L-alanine + 1 sulfoacetaldehyde." [] xref: EC:2.6.1.77 xref: GO:0031299 "molecular_function:taurine-pyruvate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_input_compound UPa:UPC00245 {cardinality="1", is_alternate="False", is_primary="True"} ! taurine relationship: has_input_compound UPa:UPC00245 ! taurine relationship: has_output_compound UPa:UPC00041 ! L-alanine relationship: has_output_compound UPa:UPC00041 {cardinality="1", is_alternate="False", is_primary="False"} ! L-alanine relationship: has_output_compound UPa:UPC00593 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfoacetaldehyde relationship: has_output_compound UPa:UPC00593 ! sulfoacetaldehyde relationship: part_of UPa:ULS00257 ! acetyl phosphate and sulfite from taurine relationship: part_of UPa:ULS00257 {cardinality="1", order="1"} ! acetyl phosphate and sulfite from taurine [Term] id: UPa:UER00544 name: acetyl phosphate and sulfite from taurine: step 2/2 namespace: enzymatic_reaction def: "1 phosphate + 1 sulfoacetaldehyde => 1 acetyl phosphate + 1 sulfite." [] xref: EC:2.3.3.15 xref: GO:0050487 "molecular_function:sulfoacetaldehyde acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_input_compound UPa:UPC00593 ! sulfoacetaldehyde relationship: has_input_compound UPa:UPC00593 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfoacetaldehyde relationship: has_output_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC00094 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfite relationship: has_output_compound UPa:UPC00227 ! acetyl phosphate relationship: has_output_compound UPa:UPC00227 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl phosphate relationship: part_of UPa:ULS00257 ! acetyl phosphate and sulfite from taurine relationship: part_of UPa:ULS00257 {cardinality="1", order="2"} ! acetyl phosphate and sulfite from taurine [Term] id: UPa:UER00545 name: sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 1/2 namespace: enzymatic_reaction def: "1 D-fructose 6-phosphate + 1 UDP-alpha-D-glucose => 1 UDP + 1 sucrose 6-phosphate." [] xref: EC:2.4.1.14 xref: GO:0046524 "molecular_function:sucrose-phosphate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00029 ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC00029 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00015 {cardinality="1", is_alternate="False", is_primary="False"} ! UDP relationship: has_output_compound UPa:UPC02591 {cardinality="1", is_alternate="False", is_primary="True"} ! sucrose 6-phosphate relationship: has_output_compound UPa:UPC02591 ! sucrose 6-phosphate relationship: part_of UPa:ULS00258 ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose relationship: part_of UPa:ULS00258 {cardinality="1", order="1"} ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose [Term] id: UPa:UER00546 name: sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 sucrose 6-phosphate => 1 phosphate + 1 sucrose." [] xref: EC:3.1.3.24 xref: GO:0050307 "molecular_function:sucrose-phosphate phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC02591 ! sucrose 6-phosphate relationship: has_input_compound UPa:UPC02591 {cardinality="1", is_alternate="False", is_primary="True"} ! sucrose 6-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00089 ! sucrose relationship: has_output_compound UPa:UPC00089 {cardinality="1", is_alternate="False", is_primary="True"} ! sucrose relationship: part_of UPa:ULS00258 ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose relationship: part_of UPa:ULS00258 {cardinality="1", order="2"} ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose [Term] id: UPa:UER00547 name: 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 CoA + 1 trans-4-coumarate => 1 4-coumaroyl-CoA + 1 AMP + 1 diphosphate." [] xref: EC:6.2.1.12 xref: GO:0016207 "molecular_function:4-coumarate-CoA ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00811 {cardinality="1", is_alternate="False", is_primary="True"} ! trans-4-coumarate relationship: has_input_compound UPa:UPC00811 ! trans-4-coumarate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00223 ! 4-coumaroyl-CoA relationship: has_output_compound UPa:UPC00223 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-coumaroyl-CoA relationship: part_of UPa:ULS00259 ! 3,4',5-trihydroxystilbene from trans-4-coumarate relationship: part_of UPa:ULS00259 {cardinality="1", order="1"} ! 3,4',5-trihydroxystilbene from trans-4-coumarate [Term] id: UPa:UER00548 name: 3,4',5-trihydroxystilbene from trans-4-coumarate: step 2/2 namespace: enzymatic_reaction def: "1 4-coumaroyl-CoA + 3 malonyl-CoA => 1 3,4',5-trihydroxystilbene + 4 CO(2) + 4 CoA." [] xref: EC:2.3.1.95 xref: GO:0050350 "molecular_function:trihydroxystilbene synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00083 ! malonyl-CoA relationship: has_input_compound UPa:UPC00083 {cardinality="1", is_alternate="False", is_primary="False"} ! malonyl-CoA relationship: has_input_compound UPa:UPC00223 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-coumaroyl-CoA relationship: has_input_compound UPa:UPC00223 ! 4-coumaroyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC03582 {cardinality="1", is_alternate="False", is_primary="True"} ! 3,4',5-trihydroxystilbene relationship: has_output_compound UPa:UPC03582 ! 3,4',5-trihydroxystilbene relationship: part_of UPa:ULS00259 ! 3,4',5-trihydroxystilbene from trans-4-coumarate relationship: part_of UPa:ULS00259 {cardinality="1", order="2"} ! 3,4',5-trihydroxystilbene from trans-4-coumarate [Term] id: UPa:UER00549 name: N-formimidoyl-L-glutamate from L-histidine: step 1/3 namespace: enzymatic_reaction def: "1 L-histidine => 1 NH(3) + 1 trans-urocanate." [] xref: EC:4.3.1.3 xref: GO:0004397 "molecular_function:histidine ammonia-lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00135 ! L-histidine relationship: has_input_compound UPa:UPC00135 {cardinality="1", is_alternate="False", is_primary="True"} ! L-histidine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00785 {cardinality="1", is_alternate="False", is_primary="True"} ! trans-urocanate relationship: has_output_compound UPa:UPC00785 ! trans-urocanate relationship: part_of UPa:ULS00260 ! N-formimidoyl-L-glutamate from L-histidine relationship: part_of UPa:ULS00260 {cardinality="1", order="1"} ! N-formimidoyl-L-glutamate from L-histidine [Term] id: UPa:UER00550 name: N-formimidoyl-L-glutamate from L-histidine: step 2/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 trans-urocanate => 1 4-imidazolone-5-propanoate." [] xref: EC:4.2.1.49 xref: GO:0016153 "molecular_function:urocanate hydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00785 {cardinality="1", is_alternate="False", is_primary="True"} ! trans-urocanate relationship: has_input_compound UPa:UPC00785 ! trans-urocanate relationship: has_output_compound UPa:UPC03680 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-imidazolone-5-propanoate relationship: has_output_compound UPa:UPC03680 ! 4-imidazolone-5-propanoate relationship: part_of UPa:ULS00260 ! N-formimidoyl-L-glutamate from L-histidine relationship: part_of UPa:ULS00260 {cardinality="1", order="2"} ! N-formimidoyl-L-glutamate from L-histidine [Term] id: UPa:UER00551 name: N-formimidoyl-L-glutamate from L-histidine: step 3/3 namespace: enzymatic_reaction def: "1 4-imidazolone-5-propanoate + 1 H(2)O => 1 N-formimidoyl-L-glutamate." [] xref: EC:3.5.2.7 xref: GO:0050480 "molecular_function:imidazolonepropionase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC03680 ! 4-imidazolone-5-propanoate relationship: has_input_compound UPa:UPC03680 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-imidazolone-5-propanoate relationship: has_output_compound UPa:UPC00439 {cardinality="1", is_alternate="False", is_primary="True"} ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate relationship: part_of UPa:ULS00260 {cardinality="1", order="3"} ! N-formimidoyl-L-glutamate from L-histidine relationship: part_of UPa:ULS00260 ! N-formimidoyl-L-glutamate from L-histidine [Term] id: UPa:UER00552 name: L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-formimidoyl-L-glutamate => 1 L-glutamate + 1 formamide." [] xref: EC:3.5.3.8 xref: GO:0050415 "molecular_function:formimidoylglutamase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00439 {cardinality="1", is_alternate="False", is_primary="True"} ! N-formimidoyl-L-glutamate relationship: has_input_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00488 {cardinality="1", is_alternate="False", is_primary="False"} ! formamide relationship: has_output_compound UPa:UPC00488 ! formamide relationship: part_of UPa:ULS00261 {cardinality="1", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (hydrolase route) relationship: part_of UPa:ULS00261 ! L-glutamate from N-formimidoyl-L-glutamate (hydrolase route) [Term] id: UPa:UER00553 name: L-glutamate from N-formimidoyl-L-glutamate (deiminase route): step 1/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-formimidoyl-L-glutamate => 1 N-formyl-L-glutamate + 1 NH(3)." [] xref: EC:3.5.3.13 xref: GO:0050416 "molecular_function:formimidoylglutamate deiminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00439 {cardinality="1", is_alternate="False", is_primary="True"} ! N-formimidoyl-L-glutamate relationship: has_input_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC01045 {cardinality="1", is_alternate="False", is_primary="True"} ! N-formyl-L-glutamate relationship: has_output_compound UPa:UPC01045 ! N-formyl-L-glutamate relationship: part_of UPa:ULS00262 ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route) relationship: part_of UPa:ULS00262 {cardinality="1", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route) [Term] id: UPa:UER00554 name: L-glutamate from N-formimidoyl-L-glutamate (deiminase route): step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-formyl-L-glutamate => 1 L-glutamate + 1 formate." [] xref: EC:3.5.1.68 xref: GO:0050129 "molecular_function:N-formylglutamate deformylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC01045 ! N-formyl-L-glutamate relationship: has_input_compound UPa:UPC01045 {cardinality="1", is_alternate="False", is_primary="True"} ! N-formyl-L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: part_of UPa:ULS00262 ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route) relationship: part_of UPa:ULS00262 {cardinality="1", order="2"} ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route) [Term] id: UPa:UER00555 name: L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1 namespace: enzymatic_reaction def: "1 5,6,7,8-tetrahydrofolate + 1 N-formimidoyl-L-glutamate => 1 5-formiminotetrahydrofolate + 1 L-glutamate." [] xref: EC:2.1.2.5 xref: GO:0030409 "molecular_function:glutamate formimidoyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00439 {cardinality="1", is_alternate="False", is_primary="True"} ! N-formimidoyl-L-glutamate relationship: has_input_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00664 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-formiminotetrahydrofolate relationship: has_output_compound UPa:UPC00664 ! 5-formiminotetrahydrofolate relationship: part_of UPa:ULS00263 {cardinality="1", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (transferase route) relationship: part_of UPa:ULS00263 ! L-glutamate from N-formimidoyl-L-glutamate (transferase route) [Term] id: UPa:UER00556 name: staphyloxanthin from farnesyl diphosphate: step 1/5 namespace: enzymatic_reaction def: "2 farnesyl diphosphate => 1 dehydrosqualene + 2 diphosphate." [] xref: EC:2.5.1.96 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00448 {cardinality="1", is_alternate="False", is_primary="True"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC16144 {cardinality="1", is_alternate="False", is_primary="True"} ! dehydrosqualene relationship: has_output_compound UPa:UPC16144 ! dehydrosqualene relationship: part_of UPa:ULS00264 {cardinality="1", order="1"} ! staphyloxanthin from farnesyl diphosphate relationship: part_of UPa:ULS00264 ! staphyloxanthin from farnesyl diphosphate [Term] id: UPa:UER00557 name: staphyloxanthin from farnesyl diphosphate: step 2/5 namespace: enzymatic_reaction def: "3 FAD + 1 dehydrosqualene => 1 4,4'-diaponeurosporene + 3 FADH2." [] xref: EC:1.3.8.2 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00016 ! FAD relationship: has_input_compound UPa:UPC00016 {cardinality="1", is_alternate="False", is_primary="False"} ! FAD relationship: has_input_compound UPa:UPC16144 ! dehydrosqualene relationship: has_input_compound UPa:UPC16144 {cardinality="1", is_alternate="False", is_primary="True"} ! dehydrosqualene relationship: has_output_compound UPa:UPC01352 ! FADH2 relationship: has_output_compound UPa:UPC01352 {cardinality="1", is_alternate="False", is_primary="False"} ! FADH2 relationship: has_output_compound UPa:UPC16145 {cardinality="1", is_alternate="False", is_primary="True"} ! 4,4'-diaponeurosporene relationship: has_output_compound UPa:UPC16145 ! 4,4'-diaponeurosporene relationship: part_of UPa:ULS00264 {cardinality="1", order="2"} ! staphyloxanthin from farnesyl diphosphate relationship: part_of UPa:ULS00264 ! staphyloxanthin from farnesyl diphosphate [Term] id: UPa:UER00558 name: staphyloxanthin from farnesyl diphosphate: step 3/5 namespace: enzymatic_reaction def: "1 4,4'-diaponeurosporene + 3 O(2) + 3 reduced acceptor => 1 4,4'-diaponeurosporenic acid + 4 H(2)O + 3 acceptor." [] xref: EC:1.14.99.44 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00030 ! reduced acceptor relationship: has_input_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_input_compound UPa:UPC16145 ! 4,4'-diaponeurosporene relationship: has_input_compound UPa:UPC16145 {cardinality="1", is_alternate="False", is_primary="True"} ! 4,4'-diaponeurosporene relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_output_compound UPa:UPC00028 ! acceptor relationship: has_output_compound UPa:UPC16146 {cardinality="1", is_alternate="False", is_primary="True"} ! 4,4'-diaponeurosporenic acid relationship: has_output_compound UPa:UPC16146 ! 4,4'-diaponeurosporenic acid relationship: part_of UPa:ULS00264 {cardinality="1", order="3"} ! staphyloxanthin from farnesyl diphosphate relationship: part_of UPa:ULS00264 ! staphyloxanthin from farnesyl diphosphate [Term] id: UPa:UER00559 name: staphyloxanthin from farnesyl diphosphate: step 4/5 namespace: enzymatic_reaction def: "1 4,4'-diaponeurosporenic acid => 1 glycosyl-4,4'-diaponeurosporenic acid." [] xref: EC:2.4.1 xref: GO:0000009 "molecular_function:alpha-1,6-mannosyltransferase activity" xref: GO:0000026 "molecular_function:alpha-1,2-mannosyltransferase activity" xref: GO:0000030 "molecular_function:mannosyltransferase activity" xref: GO:0000033 "molecular_function:alpha-1,3-mannosyltransferase activity" xref: GO:0001962 "molecular_function:alpha-1,3-galactosyltransferase activity" xref: GO:0003980 "molecular_function:UDP-glucose:glycoprotein glucosyltransferase activity" xref: GO:0004376 "molecular_function:glycolipid mannosyltransferase activity" xref: GO:0004576 "molecular_function:oligosaccharyl transferase activity" xref: GO:0004583 "molecular_function:dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity" xref: GO:0008375 "molecular_function:acetylglucosaminyltransferase activity" xref: GO:0008376 "molecular_function:acetylgalactosaminyltransferase activity" xref: GO:0008378 "molecular_function:galactosyltransferase activity" xref: GO:0008417 "molecular_function:fucosyltransferase activity" xref: GO:0008755 "molecular_function:O antigen polymerase activity" xref: GO:0008921 "molecular_function:lipopolysaccharide-1,6-galactosyltransferase activity" xref: GO:0016758 "molecular_function:transferase activity, transferring hexosyl groups" xref: GO:0016759 "molecular_function:cellulose synthase activity" xref: GO:0018715 "molecular_function:9-phenanthrol UDP-glucuronosyltransferase activity" xref: GO:0018716 "molecular_function:1-phenanthrol glycosyltransferase activity" xref: GO:0018717 "molecular_function:9-phenanthrol glycosyltransferase activity" xref: GO:0018718 "molecular_function:1,2-dihydroxy-phenanthrene glycosyltransferase activity" xref: GO:0019112 "molecular_function:phenanthrol glycosyltransferase activity" xref: GO:0019187 "molecular_function:beta-1,4-mannosyltransferase activity" xref: GO:0031278 "molecular_function:alpha-1,2-galactosyltransferase activity" xref: GO:0033556 "molecular_function:dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity" xref: GO:0035496 "molecular_function:lipopolysaccharide-1,5-galactosyltransferase activity" xref: GO:0042281 "molecular_function:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity" xref: GO:0042283 "molecular_function:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity" xref: GO:0045140 "molecular_function:inositol phosphoceramide synthase activity" xref: GO:0046527 "molecular_function:glucosyltransferase activity" xref: GO:0046920 "molecular_function:alpha-(1->3)-fucosyltransferase activity" xref: GO:0046921 "molecular_function:alpha-(1->6)-fucosyltransferase activity" xref: GO:0052638 "molecular_function:indole-3-butyrate beta-glucosyltransferase activity" xref: GO:0052639 "molecular_function:salicylic acid glucosyltransferase (ester-forming) activity" xref: GO:0052640 "molecular_function:salicylic acid glucosyltransferase (glucoside-forming) activity" xref: GO:0052641 "molecular_function:benzoic acid glucosyltransferase activity" xref: GO:0052757 "molecular_function:chondroitin hydrolase activity" xref: GO:0052824 "molecular_function:dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity" xref: GO:0080062 "molecular_function:cytokinin 9-beta-glucosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC16146 ! 4,4'-diaponeurosporenic acid relationship: has_input_compound UPa:UPC16146 {cardinality="1", is_alternate="False", is_primary="True"} ! 4,4'-diaponeurosporenic acid relationship: has_output_compound UPa:UPC16147 {cardinality="1", is_alternate="False", is_primary="True"} ! glycosyl-4,4'-diaponeurosporenic acid relationship: has_output_compound UPa:UPC16147 ! glycosyl-4,4'-diaponeurosporenic acid relationship: part_of UPa:ULS00264 {cardinality="1", order="4"} ! staphyloxanthin from farnesyl diphosphate relationship: part_of UPa:ULS00264 ! staphyloxanthin from farnesyl diphosphate [Term] id: UPa:UER00560 name: staphyloxanthin from farnesyl diphosphate: step 5/5 namespace: enzymatic_reaction def: "1 glycosyl-4,4'-diaponeurosporenic acid => 1 staphyloxanthin." [] xref: EC:2.3.1 xref: GO:0004147 "molecular_function:dihydrolipoamide branched chain acyltransferase activity" xref: GO:0004772 "molecular_function:sterol O-acyltransferase activity" xref: GO:0008080 "molecular_function:N-acetyltransferase activity" xref: GO:0008374 "molecular_function:O-acyltransferase activity" xref: GO:0008951 "molecular_function:palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity" xref: GO:0016406 "molecular_function:carnitine O-acyltransferase activity" xref: GO:0016407 "molecular_function:acetyltransferase activity" xref: GO:0016408 "molecular_function:C-acyltransferase activity" xref: GO:0016409 "molecular_function:palmitoyltransferase activity" xref: GO:0016410 "molecular_function:N-acyltransferase activity" xref: GO:0016411 "molecular_function:acylglycerol O-acyltransferase activity" xref: GO:0016412 "molecular_function:serine O-acyltransferase activity" xref: GO:0016413 "molecular_function:O-acetyltransferase activity" xref: GO:0016414 "molecular_function:O-octanoyltransferase activity" xref: GO:0016415 "molecular_function:octanoyltransferase activity" xref: GO:0016416 "molecular_function:O-palmitoyltransferase activity" xref: GO:0016417 "molecular_function:S-acyltransferase activity" xref: GO:0016418 "molecular_function:S-acetyltransferase activity" xref: GO:0016419 "molecular_function:S-malonyltransferase activity" xref: GO:0016420 "molecular_function:malonyltransferase activity" xref: GO:0016454 "molecular_function:C-palmitoyltransferase activity" xref: GO:0016747 "molecular_function:transferase activity, transferring acyl groups other than amino-acyl groups" xref: GO:0016748 "molecular_function:succinyltransferase activity" xref: GO:0016749 "molecular_function:N-succinyltransferase activity" xref: GO:0016750 "molecular_function:O-succinyltransferase activity" xref: GO:0016751 "molecular_function:S-succinyltransferase activity" xref: GO:0016752 "molecular_function:sinapoyltransferase activity" xref: GO:0016753 "molecular_function:O-sinapoyltransferase activity" xref: GO:0018030 "molecular_function:peptidyl-lysine N6-myristoyltransferase activity" xref: GO:0018031 "molecular_function:peptidyl-lysine N6-palmitoyltransferase activity" xref: GO:0018711 "molecular_function:benzoyl acetate-CoA thiolase activity" xref: GO:0018712 "molecular_function:3-hydroxybutyryl-CoA thiolase activity" xref: GO:0018713 "molecular_function:3-ketopimelyl-CoA thiolase activity" xref: GO:0019105 "molecular_function:N-palmitoyltransferase activity" xref: GO:0019107 "molecular_function:myristoyltransferase activity" xref: GO:0019186 "molecular_function:acyl-CoA N-acyltransferase activity" xref: GO:0019705 "molecular_function:protein-cysteine S-myristoyltransferase activity" xref: GO:0019707 "molecular_function:protein-cysteine S-acyltransferase activity" xref: GO:0030523 "molecular_function:dihydrolipoamide S-acyltransferase activity" xref: GO:0032216 "molecular_function:glucosaminyl-phosphotidylinositol O-acyltransferase activity" xref: GO:0034737 "molecular_function:ergosterol O-acyltransferase activity" xref: GO:0034738 "molecular_function:lanosterol O-acyltransferase activity" xref: GO:0034848 "molecular_function:naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity" xref: GO:0034851 "molecular_function:2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity" xref: GO:0034915 "molecular_function:2-methylhexanoyl-CoA C-acetyltransferase activity" xref: GO:0034919 "molecular_function:butyryl-CoA 2-C-propionyltransferase activity" xref: GO:0034945 "molecular_function:2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity" xref: GO:0043741 "molecular_function:L-2-aminoadipate N-acetyltransferase activity" xref: GO:0043764 "molecular_function:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity" xref: GO:0043806 "molecular_function:keto acid formate lyase activity" xref: GO:0043849 "molecular_function:Ras palmitoyltransferase activity" xref: GO:0043875 "molecular_function:2-ketobutyrate formate-lyase activity" xref: GO:0046941 "molecular_function:azetidine-2-carboxylic acid acetyltransferase activity" xref: GO:0052858 "molecular_function:peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor" xref: GO:0090595 "molecular_function:acetyl-CoA:L-lysine N6-acetyltransferase" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC16147 {cardinality="1", is_alternate="False", is_primary="True"} ! glycosyl-4,4'-diaponeurosporenic acid relationship: has_input_compound UPa:UPC16147 ! glycosyl-4,4'-diaponeurosporenic acid relationship: has_output_compound UPa:UPC16148 ! staphyloxanthin relationship: has_output_compound UPa:UPC16148 {cardinality="1", is_alternate="False", is_primary="True"} ! staphyloxanthin relationship: part_of UPa:ULS00264 {cardinality="1", order="5"} ! staphyloxanthin from farnesyl diphosphate relationship: part_of UPa:ULS00264 ! staphyloxanthin from farnesyl diphosphate [Term] id: UPa:UER00561 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 5/10 namespace: enzymatic_reaction def: "1 H(2)O + 1 cobalt-precorrin 5A => 1 acetaldehyde + 1 cobalt-precorrin 5B." [] xref: EC:3.7.1.12 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC16242 ! cobalt-precorrin 5A relationship: has_input_compound UPa:UPC16242 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 5A relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: has_output_compound UPa:UPC00084 {cardinality="1", is_alternate="False", is_primary="False"} ! acetaldehyde relationship: has_output_compound UPa:UPC16243 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 5B relationship: has_output_compound UPa:UPC16243 ! cobalt-precorrin 5B relationship: part_of UPa:ULS00092 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) relationship: part_of UPa:ULS00092 {cardinality="1", order="5"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00562 name: ethylene from S-adenosyl-L-methionine: step 1/2 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine => 1 1-aminocyclopropanecarboxylate + 1 S-methyl-5'-thioadenosine." [] xref: EC:4.4.1.14 xref: GO:0016847 "molecular_function:1-aminocyclopropane-1-carboxylate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="True"} ! S-adenosyl-L-methionine relationship: has_output_compound UPa:UPC00170 {cardinality="1", is_alternate="False", is_primary="False"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC01234 ! 1-aminocyclopropanecarboxylate relationship: has_output_compound UPa:UPC01234 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-aminocyclopropanecarboxylate relationship: part_of UPa:ULS00265 ! ethylene from S-adenosyl-L-methionine relationship: part_of UPa:ULS00265 {cardinality="1", order="1"} ! ethylene from S-adenosyl-L-methionine [Term] id: UPa:UER00563 name: ethylene from S-adenosyl-L-methionine: step 2/2 namespace: enzymatic_reaction def: "1 1-aminocyclopropanecarboxylate + 1 L-ascorbate + 1 O(2) => 1 CO(2) + 2 H(2)O + 1 L-dehydroascorbate + 1 ethylene + 1 hydrogen cyanide." [] xref: EC:1.14.17.4 xref: GO:0009815 "molecular_function:1-aminocyclopropane-1-carboxylate oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00072 {cardinality="1", is_alternate="False", is_primary="False"} ! L-ascorbate relationship: has_input_compound UPa:UPC00072 ! L-ascorbate relationship: has_input_compound UPa:UPC01234 ! 1-aminocyclopropanecarboxylate relationship: has_input_compound UPa:UPC01234 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-aminocyclopropanecarboxylate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00177 {cardinality="1", is_alternate="False", is_primary="False"} ! hydrogen cyanide relationship: has_output_compound UPa:UPC00177 ! hydrogen cyanide relationship: has_output_compound UPa:UPC05422 ! L-dehydroascorbate relationship: has_output_compound UPa:UPC05422 {cardinality="1", is_alternate="False", is_primary="False"} ! L-dehydroascorbate relationship: has_output_compound UPa:UPC06547 ! ethylene relationship: has_output_compound UPa:UPC06547 {cardinality="1", is_alternate="False", is_primary="True"} ! ethylene relationship: part_of UPa:ULS00265 ! ethylene from S-adenosyl-L-methionine relationship: part_of UPa:ULS00265 {cardinality="1", order="2"} ! ethylene from S-adenosyl-L-methionine [Term] id: UPa:UER00564 name: geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 farnesyl diphosphate + 1 isopentenyl diphosphate => 1 diphosphate + 1 geranylgeranyl diphosphate." [] xref: EC:2.5.1.29 xref: GO:0004311 "molecular_function:farnesyltranstransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00129 {cardinality="1", is_alternate="False", is_primary="True"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00448 {cardinality="1", is_alternate="False", is_primary="True"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00353 {cardinality="1", is_alternate="False", is_primary="True"} ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC00353 ! geranylgeranyl diphosphate relationship: part_of UPa:ULS00266 {cardinality="1", order="1"} ! geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate relationship: part_of UPa:ULS00266 ! geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate [Term] id: UPa:UER00565 name: D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3 namespace: enzymatic_reaction def: "1 L-arabinose => 1 L-ribulose." [] xref: EC:5.3.1.4 xref: GO:0008733 "molecular_function:L-arabinose isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00259 ! L-arabinose relationship: has_input_compound UPa:UPC00259 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinose relationship: has_output_compound UPa:UPC00508 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ribulose relationship: has_output_compound UPa:UPC00508 ! L-ribulose relationship: part_of UPa:ULS00049 ! D-xylulose 5-phosphate from L-arabinose (bacterial route) relationship: part_of UPa:ULS00049 {cardinality="1", order="1"} ! D-xylulose 5-phosphate from L-arabinose (bacterial route) [Term] id: UPa:UER00566 name: D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3 namespace: enzymatic_reaction def: "1 ATP + 1 L-ribulose => 1 ADP + 1 L-ribulose 5-phosphate." [] xref: EC:2.7.1.16 xref: GO:0008741 "molecular_function:ribulokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00508 ! L-ribulose relationship: has_input_compound UPa:UPC00508 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ribulose relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC01101 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ribulose 5-phosphate relationship: has_output_compound UPa:UPC01101 ! L-ribulose 5-phosphate relationship: part_of UPa:ULS00049 ! D-xylulose 5-phosphate from L-arabinose (bacterial route) relationship: part_of UPa:ULS00049 {cardinality="1", order="2"} ! D-xylulose 5-phosphate from L-arabinose (bacterial route) [Term] id: UPa:UER00567 name: D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3 namespace: enzymatic_reaction def: "1 L-ribulose 5-phosphate => 1 D-xylulose 5-phosphate." [] xref: EC:5.1.3.4 xref: GO:0008742 "molecular_function:L-ribulose-phosphate 4-epimerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01101 ! L-ribulose 5-phosphate relationship: has_input_compound UPa:UPC01101 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 {cardinality="1", is_alternate="False", is_primary="True"} ! D-xylulose 5-phosphate relationship: part_of UPa:ULS00049 ! D-xylulose 5-phosphate from L-arabinose (bacterial route) relationship: part_of UPa:ULS00049 {cardinality="1", order="3"} ! D-xylulose 5-phosphate from L-arabinose (bacterial route) [Term] id: UPa:UER00568 name: 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 1/3 namespace: enzymatic_reaction def: "1 L-arabinose + 1 NAD(+) => 1 H(+) + 1 L-arabinono-1,4-lactone + 1 NADH." [] xref: EC:1.1.1.46 xref: GO:0050022 "molecular_function:L-arabinose 1-dehydrogenase (NAD+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00259 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinose relationship: has_input_compound UPa:UPC00259 ! L-arabinose relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC01114 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC01114 ! L-arabinono-1,4-lactone relationship: part_of UPa:ULS00267 ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose relationship: part_of UPa:ULS00267 {cardinality="1", order="1"} ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose [Term] id: UPa:UER00569 name: 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 2/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-arabinono-1,4-lactone => 1 L-arabinonate." [] xref: EC:3.1.1.15 xref: GO:0050021 "molecular_function:L-arabinonolactonase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC01114 ! L-arabinono-1,4-lactone relationship: has_input_compound UPa:UPC01114 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC00545 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinonate relationship: has_output_compound UPa:UPC00545 ! L-arabinonate relationship: part_of UPa:ULS00267 ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose relationship: part_of UPa:ULS00267 {cardinality="1", order="2"} ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose [Term] id: UPa:UER00570 name: 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 3/3 namespace: enzymatic_reaction def: "1 L-arabinonate => 1 2-dehydro-3-deoxy-L-arabinonate + 1 H(2)O." [] xref: EC:4.2.1.25 xref: GO:0050020 "molecular_function:L-arabinonate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00545 ! L-arabinonate relationship: has_input_compound UPa:UPC00545 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinonate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00684 ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_output_compound UPa:UPC00684 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydro-3-deoxy-L-arabinonate relationship: part_of UPa:ULS00267 ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose relationship: part_of UPa:ULS00267 {cardinality="1", order="3"} ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose [Term] id: UPa:UER00571 name: glycolaldehyde and pyruvate from 2-dehydro-3-deoxy-L-arabinonate: step 1/1 namespace: enzymatic_reaction def: "1 2-dehydro-3-deoxy-L-arabinonate => 1 glycolaldehyde + 1 pyruvate." [] xref: EC:4.1.2.18 xref: GO:0047438 "molecular_function:2-dehydro-3-deoxy-L-pentonate aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00684 ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_input_compound UPa:UPC00684 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00266 {cardinality="1", is_alternate="False", is_primary="True"} ! glycolaldehyde relationship: has_output_compound UPa:UPC00266 ! glycolaldehyde relationship: part_of UPa:ULS00268 ! glycolaldehyde and pyruvate from 2-dehydro-3-deoxy-L-arabinonate relationship: part_of UPa:ULS00268 {cardinality="1", order="1"} ! glycolaldehyde and pyruvate from 2-dehydro-3-deoxy-L-arabinonate [Term] id: UPa:UER00572 name: 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate: step 1/2 namespace: enzymatic_reaction def: "1 2-dehydro-3-deoxy-L-arabinonate => 1 2,5-dioxopentanoate + 1 H(2)O." [] xref: EC:4.2.1.43 xref: GO:0047449 "molecular_function:2-dehydro-3-deoxy-L-arabinonate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00684 ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_input_compound UPa:UPC00684 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00433 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,5-dioxopentanoate relationship: has_output_compound UPa:UPC00433 ! 2,5-dioxopentanoate relationship: part_of UPa:ULS00269 ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate relationship: part_of UPa:ULS00269 {cardinality="1", order="1"} ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate [Term] id: UPa:UER00573 name: 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate: step 2/2 namespace: enzymatic_reaction def: "1 2,5-dioxopentanoate + 1 H(2)O + 1 NADP(+) => 1 2-oxoglutarate + 1 H(+) + 1 NADPH." [] xref: EC:1.2.1.26 xref: GO:0047533 "molecular_function:2,5-dioxovalerate dehydrogenase (NADP+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00433 ! 2,5-dioxopentanoate relationship: has_input_compound UPa:UPC00433 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,5-dioxopentanoate relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:ULS00269 {cardinality="1", order="2"} ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate relationship: part_of UPa:ULS00269 ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate [Term] id: UPa:UER00574 name: D-xylulose 5-phosphate from L-arabinose (fungal route): step 1/5 namespace: enzymatic_reaction def: "H(+) + L-arabinose + [NADH or NADPH] => L-arabinitol + [NAD(+) or NADP(+)]." [] xref: EC:1.1.1.21 xref: GO:0004032 "molecular_function:alditol:NADP+ 1-oxidoreductase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00969 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00970 ! None relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00259 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinose relationship: has_input_compound UPa:UPC00259 ! L-arabinose relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00532 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinitol relationship: has_output_compound UPa:UPC00532 ! L-arabinitol relationship: part_of UPa:ULS00270 ! D-xylulose 5-phosphate from L-arabinose (fungal route) relationship: part_of UPa:ULS00270 {cardinality="1", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route) [Term] id: UPa:UER00575 name: D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5 namespace: enzymatic_reaction def: "1 L-arabinitol + 1 NAD(+) => 1 H(+) + 1 L-xylulose + 1 NADH." [] xref: EC:1.1.1.12 xref: GO:0050019 "molecular_function:L-arabinitol 4-dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00532 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinitol relationship: has_input_compound UPa:UPC00532 ! L-arabinitol relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00312 ! L-xylulose relationship: has_output_compound UPa:UPC00312 {cardinality="1", is_alternate="False", is_primary="True"} ! L-xylulose relationship: part_of UPa:ULS00270 ! D-xylulose 5-phosphate from L-arabinose (fungal route) relationship: part_of UPa:ULS00270 {cardinality="1", order="2"} ! D-xylulose 5-phosphate from L-arabinose (fungal route) [Term] id: UPa:UER00576 name: D-xylulose 5-phosphate from L-arabinose (fungal route): step 3/5 namespace: enzymatic_reaction def: "1 H(+) + 1 L-xylulose + 1 NADPH => 1 NADP(+) + 1 xylitol." [] xref: EC:1.1.1.10 xref: GO:0050038 "molecular_function:L-xylulose reductase (NADP+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00312 {cardinality="1", is_alternate="False", is_primary="True"} ! L-xylulose relationship: has_input_compound UPa:UPC00312 ! L-xylulose relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00379 ! xylitol relationship: has_output_compound UPa:UPC00379 {cardinality="1", is_alternate="False", is_primary="True"} ! xylitol relationship: part_of UPa:ULS00270 {cardinality="1", order="3"} ! D-xylulose 5-phosphate from L-arabinose (fungal route) relationship: part_of UPa:ULS00270 ! D-xylulose 5-phosphate from L-arabinose (fungal route) [Term] id: UPa:UER00577 name: D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5 namespace: enzymatic_reaction def: "1 NAD(+) + 1 xylitol => 1 D-xylulose + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.9 xref: GO:0046526 "molecular_function:D-xylulose reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00379 {cardinality="1", is_alternate="False", is_primary="True"} ! xylitol relationship: has_input_compound UPa:UPC00379 ! xylitol relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00310 ! D-xylulose relationship: has_output_compound UPa:UPC00310 {cardinality="1", is_alternate="False", is_primary="True"} ! D-xylulose relationship: part_of UPa:ULS00270 {cardinality="1", order="4"} ! D-xylulose 5-phosphate from L-arabinose (fungal route) relationship: part_of UPa:ULS00270 ! D-xylulose 5-phosphate from L-arabinose (fungal route) [Term] id: UPa:UER00578 name: D-xylulose 5-phosphate from L-arabinose (fungal route): step 5/5 namespace: enzymatic_reaction def: "1 ATP + 1 D-xylulose => 1 ADP + 1 D-xylulose 5-phosphate." [] xref: EC:2.7.1.17 xref: GO:0004856 "molecular_function:xylulokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00310 {cardinality="1", is_alternate="False", is_primary="True"} ! D-xylulose relationship: has_input_compound UPa:UPC00310 ! D-xylulose relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00231 {cardinality="1", is_alternate="False", is_primary="True"} ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: part_of UPa:ULS00270 ! D-xylulose 5-phosphate from L-arabinose (fungal route) relationship: part_of UPa:ULS00270 {cardinality="1", order="5"} ! D-xylulose 5-phosphate from L-arabinose (fungal route) [Term] id: UPa:UER00579 name: creatine from L-arginine and glycine: step 1/2 namespace: enzymatic_reaction def: "1 L-arginine + 1 glycine => 1 L-ornithine + 1 guanidinoacetate." [] xref: EC:2.1.4.1 xref: GO:0015068 "molecular_function:glycine amidinotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="True"} ! glycine relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_output_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="False"} ! L-ornithine relationship: has_output_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00581 ! guanidinoacetate relationship: has_output_compound UPa:UPC00581 {cardinality="1", is_alternate="False", is_primary="True"} ! guanidinoacetate relationship: part_of UPa:ULS00271 ! creatine from L-arginine and glycine relationship: part_of UPa:ULS00271 {cardinality="1", order="1"} ! creatine from L-arginine and glycine [Term] id: UPa:UER00580 name: creatine from L-arginine and glycine: step 2/2 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 guanidinoacetate => 1 S-adenosyl-L-homocysteine + 1 creatine." [] xref: EC:2.1.1.2 xref: GO:0030731 "molecular_function:guanidinoacetate N-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00581 ! guanidinoacetate relationship: has_input_compound UPa:UPC00581 {cardinality="1", is_alternate="False", is_primary="True"} ! guanidinoacetate relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00300 ! creatine relationship: has_output_compound UPa:UPC00300 {cardinality="1", is_alternate="False", is_primary="True"} ! creatine relationship: part_of UPa:ULS00271 {cardinality="1", order="2"} ! creatine from L-arginine and glycine relationship: part_of UPa:ULS00271 ! creatine from L-arginine and glycine [Term] id: UPa:UER00581 name: pentalenene from farnesyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 farnesyl diphosphate => 1 diphosphate + 1 pentalenene." [] xref: EC:4.2.3.7 xref: GO:0050467 "molecular_function:pentalenene synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00448 {cardinality="1", is_alternate="False", is_primary="True"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC01841 {cardinality="1", is_alternate="False", is_primary="True"} ! pentalenene relationship: has_output_compound UPa:UPC01841 ! pentalenene relationship: part_of UPa:ULS00272 {cardinality="1", order="1"} ! pentalenene from farnesyl diphosphate relationship: part_of UPa:ULS00272 ! pentalenene from farnesyl diphosphate [Term] id: UPa:UER00582 name: aristolochene from farnesyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 farnesyl diphosphate => 1 aristolochene + 1 diphosphate." [] xref: EC:4.2.3.9 xref: GO:0045483 "molecular_function:aristolochene synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00448 {cardinality="1", is_alternate="False", is_primary="True"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC02004 ! aristolochene relationship: has_output_compound UPa:UPC02004 {cardinality="1", is_alternate="False", is_primary="True"} ! aristolochene relationship: part_of UPa:ULS00273 {cardinality="1", order="1"} ! aristolochene from farnesyl diphosphate relationship: part_of UPa:ULS00273 ! aristolochene from farnesyl diphosphate [Term] id: UPa:UER00583 name: germacradienol from farnesyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 farnesyl diphosphate => 1 diphosphate + 1 germacradienol." [] xref: EC:4.2.3.22 xref: GO:0034004 "molecular_function:germacradienol synthase activity" xref: GO:0052577 "molecular_function:germacrene-D synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00448 {cardinality="1", is_alternate="False", is_primary="True"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC16143 {cardinality="1", is_alternate="False", is_primary="True"} ! germacradienol relationship: has_output_compound UPa:UPC16143 ! germacradienol relationship: part_of UPa:ULS00274 {cardinality="1", order="1"} ! germacradienol from farnesyl diphosphate relationship: part_of UPa:ULS00274 ! germacradienol from farnesyl diphosphate [Term] id: UPa:UER00584 name: germacrene D from farnesyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 farnesyl diphosphate => 1 diphosphate + 1 germacrene D." [] xref: EC:4.2.3.22 xref: GO:0034004 "molecular_function:germacradienol synthase activity" xref: GO:0052577 "molecular_function:germacrene-D synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00448 {cardinality="1", is_alternate="False", is_primary="True"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC16142 {cardinality="1", is_alternate="False", is_primary="True"} ! germacrene D relationship: has_output_compound UPa:UPC16142 ! germacrene D relationship: part_of UPa:ULS00275 {cardinality="1", order="1"} ! germacrene D from farnesyl diphosphate relationship: part_of UPa:ULS00275 ! germacrene D from farnesyl diphosphate [Term] id: UPa:UER00585 name: NH(3) and pyruvate from L-alanine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-alanine + 1 NAD(+) => 1 H(+) + 1 NADH + 1 NH(3) + 1 pyruvate." [] xref: EC:1.4.1.1 xref: GO:0000286 "molecular_function:alanine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_input_compound UPa:UPC00041 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alanine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="True"} ! NH(3) relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: part_of UPa:ULS00276 {cardinality="1", order="1"} ! NH(3) and pyruvate from L-alanine relationship: part_of UPa:ULS00276 ! NH(3) and pyruvate from L-alanine [Term] id: UPa:UER00586 name: pyruvate from L-alanine: step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 L-alanine => 1 L-glutamate + 1 pyruvate." [] xref: EC:2.6.1.2 xref: GO:0004021 "molecular_function:L-alanine:2-oxoglutarate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_input_compound UPa:UPC00041 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alanine relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: part_of UPa:ULS00277 {cardinality="1", order="1"} ! pyruvate from L-alanine relationship: part_of UPa:ULS00277 ! pyruvate from L-alanine [Term] id: UPa:UER00587 name: betaine aldehyde from choline (dehydrogenase route): step 1/1 namespace: enzymatic_reaction def: "1 NAD(+) + 1 choline => 1 H(+) + 1 NADH + 1 betaine aldehyde." [] xref: EC:1.1.1 xref: GO:0000252 "molecular_function:C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity" xref: GO:0004033 "molecular_function:aldo-keto reductase (NADP) activity" xref: GO:0004448 "molecular_function:isocitrate dehydrogenase activity" xref: GO:0004495 "molecular_function:mevaldate reductase activity" xref: GO:0008875 "molecular_function:gluconate dehydrogenase activity" xref: GO:0016229 "molecular_function:steroid dehydrogenase activity" xref: GO:0016616 "molecular_function:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" xref: GO:0018451 "molecular_function:epoxide dehydrogenase activity" xref: GO:0018452 "molecular_function:5-exo-hydroxycamphor dehydrogenase activity" xref: GO:0018453 "molecular_function:2-hydroxytetrahydrofuran dehydrogenase activity" xref: GO:0019152 "molecular_function:acetoin dehydrogenase activity" xref: GO:0032442 "molecular_function:phenylcoumaran benzylic ether reductase activity" xref: GO:0032866 "molecular_function:D-xylose:NADP reductase activity" xref: GO:0032867 "molecular_function:L-arabinose:NADP reductase activity" xref: GO:0033709 "molecular_function:D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity" xref: GO:0033764 "molecular_function:steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" xref: GO:0033765 "molecular_function:steroid dehydrogenase activity, acting on the CH-CH group of donors" xref: GO:0034831 "molecular_function:(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity" xref: GO:0034840 "molecular_function:3-hydroxymenthone dehydrogenase activity" xref: GO:0035380 "molecular_function:very long-chain-3-hydroxyacyl-CoA dehydrogenase activity" xref: GO:0035410 "molecular_function:dihydrotestosterone 17-beta-dehydrogenase activity" xref: GO:0043713 "molecular_function:(R)-2-hydroxyisocaproate dehydrogenase activity" xref: GO:0044103 "molecular_function:L-arabinose 1-dehydrogenase (NADP+) activity" xref: GO:0044105 "molecular_function:L-xylulose reductase (NAD+) activity" xref: GO:0048258 "molecular_function:3-ketoglucose-reductase activity" xref: GO:0051990 "molecular_function:(R)-2-hydroxyglutarate dehydrogenase activity" xref: GO:0052677 "molecular_function:D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00114 {cardinality="1", is_alternate="False", is_primary="True"} ! choline relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00576 {cardinality="1", is_alternate="False", is_primary="True"} ! betaine aldehyde relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde relationship: part_of UPa:ULS00278 ! betaine aldehyde from choline (dehydrogenase route) relationship: part_of UPa:ULS00278 {cardinality="1", order="1"} ! betaine aldehyde from choline (dehydrogenase route) [Term] id: UPa:UER00588 name: 4-pyridoxate from pyridoxal: step 1/2 namespace: enzymatic_reaction def: "1 NAD(+) + 1 pyridoxal => 1 4-pyridoxolactone + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.107 xref: GO:0050235 "molecular_function:pyridoxal 4-dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00250 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxal relationship: has_input_compound UPa:UPC00250 ! pyridoxal relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00971 ! 4-pyridoxolactone relationship: has_output_compound UPa:UPC00971 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-pyridoxolactone relationship: part_of UPa:ULS00279 ! 4-pyridoxate from pyridoxal relationship: part_of UPa:ULS00279 {cardinality="1", order="1"} ! 4-pyridoxate from pyridoxal [Term] id: UPa:UER00589 name: 4-pyridoxate from pyridoxal: step 2/2 namespace: enzymatic_reaction def: "1 4-pyridoxolactone + 1 H(2)O => 1 4-pyridoxate." [] xref: EC:3.1.1.27 xref: GO:0047585 "molecular_function:4-pyridoxolactonase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00971 ! 4-pyridoxolactone relationship: has_input_compound UPa:UPC00971 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-pyridoxolactone relationship: has_output_compound UPa:UPC00847 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-pyridoxate relationship: has_output_compound UPa:UPC00847 ! 4-pyridoxate relationship: part_of UPa:ULS00279 {cardinality="1", order="2"} ! 4-pyridoxate from pyridoxal relationship: part_of UPa:ULS00279 ! 4-pyridoxate from pyridoxal [Term] id: UPa:UER00590 name: pyridoxal from pyridoxine (oxidase route): step 1/1 namespace: enzymatic_reaction def: "1 O(2) + 1 pyridoxine => 1 H(2)O(2) + 1 pyridoxal." [] xref: EC:1.1.3.12 xref: GO:0050237 "molecular_function:pyridoxine 4-oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00314 ! pyridoxine relationship: has_input_compound UPa:UPC00314 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxine relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00250 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxal relationship: has_output_compound UPa:UPC00250 ! pyridoxal relationship: part_of UPa:ULS00280 ! pyridoxal from pyridoxine (oxidase route) relationship: part_of UPa:ULS00280 {cardinality="1", order="1"} ! pyridoxal from pyridoxine (oxidase route) [Term] id: UPa:UER00591 name: crotonoyl-CoA from L-glutamate: step 1/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-glutamate + 1 NAD(+) => 1 2-oxoglutarate + 1 H(+) + 1 NADH + 1 NH(3)." [] xref: EC:1.4.1.2 xref: GO:0004352 "molecular_function:glutamate dehydrogenase (NAD+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:ULS00335 {cardinality="1", order="1"} ! crotonoyl-CoA from L-glutamate relationship: part_of UPa:ULS00335 ! crotonoyl-CoA from L-glutamate [Term] id: UPa:UER00592 name: protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2 namespace: enzymatic_reaction def: "1 apoprotein + 1 octanoyl-[acyl-carrier-protein] => 1 acyl-carrier protein + 1 protein N(6)-(octanoyl)lysine." [] xref: EC:2.3.1.181 xref: GO:0033819 "molecular_function:lipoyl(octanoyl) transferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC05752 {cardinality="1", is_alternate="False", is_primary="True"} ! octanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC05752 ! octanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC16240 {cardinality="1", is_alternate="False", is_primary="False"} ! apoprotein relationship: has_input_compound UPa:UPC16240 ! apoprotein relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein relationship: has_output_compound UPa:UPC00229 {cardinality="1", is_alternate="False", is_primary="False"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC16236 {cardinality="1", is_alternate="False", is_primary="True"} ! protein N(6)-(octanoyl)lysine relationship: has_output_compound UPa:UPC16236 ! protein N(6)-(octanoyl)lysine relationship: part_of UPa:ULS00282 ! protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein] relationship: part_of UPa:ULS00282 {cardinality="1", order="1"} ! protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein] [Term] id: UPa:UER00593 name: protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2 namespace: enzymatic_reaction def: "2 S-adenosyl-L-methionine + 1 protein N(6)-(octanoyl)lysine + 2 sulfur donor => 2 5'-deoxyadenosine + 2 L-methionine + 1 protein N(6)-(lipoyl)lysine." [] xref: EC:2.8.1.8 xref: GO:0016992 "molecular_function:lipoate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC16236 ! protein N(6)-(octanoyl)lysine relationship: has_input_compound UPa:UPC16236 {cardinality="1", is_alternate="False", is_primary="True"} ! protein N(6)-(octanoyl)lysine relationship: has_input_compound UPa:UPC17023 ! sulfur donor relationship: has_input_compound UPa:UPC17023 {cardinality="1", is_alternate="False", is_primary="False"} ! sulfur donor relationship: has_output_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="False"} ! L-methionine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC05198 {cardinality="1", is_alternate="False", is_primary="False"} ! 5'-deoxyadenosine relationship: has_output_compound UPa:UPC05198 ! 5'-deoxyadenosine relationship: has_output_compound UPa:UPC16237 {cardinality="1", is_alternate="False", is_primary="True"} ! protein N(6)-(lipoyl)lysine relationship: has_output_compound UPa:UPC16237 ! protein N(6)-(lipoyl)lysine relationship: part_of UPa:ULS00282 ! protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein] relationship: part_of UPa:ULS00282 {cardinality="1", order="2"} ! protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein] [Term] id: UPa:UER00594 name: protein N(6)-(lipoyl)lysine from lipoate: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 lipoate => 1 diphosphate + 1 lipoyl-AMP." [] xref: EC:2.7.7.63 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00725 {cardinality="1", is_alternate="False", is_primary="True"} ! lipoate relationship: has_input_compound UPa:UPC00725 ! lipoate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC16238 {cardinality="1", is_alternate="False", is_primary="True"} ! lipoyl-AMP relationship: has_output_compound UPa:UPC16238 ! lipoyl-AMP relationship: part_of UPa:ULS00281 ! protein N(6)-(lipoyl)lysine from lipoate relationship: part_of UPa:ULS00281 {cardinality="1", order="1"} ! protein N(6)-(lipoyl)lysine from lipoate [Term] id: UPa:UER00595 name: protein N(6)-(lipoyl)lysine from lipoate: step 2/2 namespace: enzymatic_reaction def: "1 apoprotein + 1 lipoyl-AMP => 1 AMP + 1 protein N(6)-(lipoyl)lysine." [] xref: EC:2.7.7.63 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC16238 {cardinality="1", is_alternate="False", is_primary="True"} ! lipoyl-AMP relationship: has_input_compound UPa:UPC16238 ! lipoyl-AMP relationship: has_input_compound UPa:UPC16240 {cardinality="1", is_alternate="False", is_primary="False"} ! apoprotein relationship: has_input_compound UPa:UPC16240 ! apoprotein relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC16237 {cardinality="1", is_alternate="False", is_primary="True"} ! protein N(6)-(lipoyl)lysine relationship: has_output_compound UPa:UPC16237 ! protein N(6)-(lipoyl)lysine relationship: part_of UPa:ULS00281 ! protein N(6)-(lipoyl)lysine from lipoate relationship: part_of UPa:ULS00281 {cardinality="1", order="2"} ! protein N(6)-(lipoyl)lysine from lipoate [Term] id: UPa:UER00596 name: thiamine phosphate from thiamine: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 thiamine => 1 ADP + 1 thiamine phosphate." [] xref: EC:2.7.1.89 xref: GO:0019165 "molecular_function:thiamine kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00378 {cardinality="1", is_alternate="False", is_primary="True"} ! thiamine relationship: has_input_compound UPa:UPC00378 ! thiamine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC01081 {cardinality="1", is_alternate="False", is_primary="True"} ! thiamine phosphate relationship: has_output_compound UPa:UPC01081 ! thiamine phosphate relationship: part_of UPa:ULS00284 ! thiamine phosphate from thiamine relationship: part_of UPa:ULS00284 {cardinality="1", order="1"} ! thiamine phosphate from thiamine [Term] id: UPa:UER00597 name: thiamine diphosphate from thiamine: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 thiamine => 1 AMP + 1 thiamine diphosphate." [] xref: EC:2.7.6.2 xref: GO:0004788 "molecular_function:thiamine diphosphokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00378 {cardinality="1", is_alternate="False", is_primary="True"} ! thiamine relationship: has_input_compound UPa:UPC00378 ! thiamine relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00068 {cardinality="1", is_alternate="False", is_primary="True"} ! thiamine diphosphate relationship: has_output_compound UPa:UPC00068 ! thiamine diphosphate relationship: part_of UPa:ULS00285 {cardinality="1", order="1"} ! thiamine diphosphate from thiamine relationship: part_of UPa:ULS00285 ! thiamine diphosphate from thiamine [Term] id: UPa:UER00598 name: CO(2) and formate from oxalate: step 1/2 namespace: enzymatic_reaction def: "1 formyl-CoA + 1 oxalate => 1 formate + 1 oxalyl-CoA." [] xref: EC:2.8.3.16 xref: GO:0033608 "molecular_function:formyl-CoA transferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00209 ! oxalate relationship: has_input_compound UPa:UPC00209 {cardinality="1", is_alternate="False", is_primary="True"} ! oxalate relationship: has_input_compound UPa:UPC00798 {cardinality="1", is_alternate="False", is_primary="False"} ! formyl-CoA relationship: has_input_compound UPa:UPC00798 ! formyl-CoA relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="True"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00313 {cardinality="1", is_alternate="False", is_primary="True"} ! oxalyl-CoA relationship: has_output_compound UPa:UPC00313 ! oxalyl-CoA relationship: part_of UPa:ULS00286 {cardinality="1", order="1"} ! CO(2) and formate from oxalate relationship: part_of UPa:ULS00286 ! CO(2) and formate from oxalate [Term] id: UPa:UER00599 name: CO(2) and formate from oxalate: step 2/2 namespace: enzymatic_reaction def: "1 oxalyl-CoA => 1 CO(2) + 1 formyl-CoA." [] xref: EC:4.1.1.8 xref: GO:0008949 "molecular_function:oxalyl-CoA decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00313 {cardinality="1", is_alternate="False", is_primary="True"} ! oxalyl-CoA relationship: has_input_compound UPa:UPC00313 ! oxalyl-CoA relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="True"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00798 {cardinality="1", is_alternate="False", is_primary="False"} ! formyl-CoA relationship: has_output_compound UPa:UPC00798 ! formyl-CoA relationship: part_of UPa:ULS00286 ! CO(2) and formate from oxalate relationship: part_of UPa:ULS00286 {cardinality="1", order="2"} ! CO(2) and formate from oxalate [Term] id: UPa:UER00600 name: NAD(+) from nicotinamide D-ribonucleotide: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 nicotinamide D-ribonucleotide => 1 NAD(+) + 1 diphosphate." [] xref: EC:2.7.7.1 xref: GO:0000309 "molecular_function:nicotinamide-nucleotide adenylyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00455 ! nicotinamide D-ribonucleotide relationship: has_input_compound UPa:UPC00455 {cardinality="1", is_alternate="False", is_primary="True"} ! nicotinamide D-ribonucleotide relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="True"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: part_of UPa:ULS00287 ! NAD(+) from nicotinamide D-ribonucleotide relationship: part_of UPa:ULS00287 {cardinality="1", order="1"} ! NAD(+) from nicotinamide D-ribonucleotide [Term] id: UPa:UER00601 name: glycerone phosphate from L-rhamnose: step 1/3 namespace: enzymatic_reaction def: "1 L-rhamnose => 1 L-rhamnulose." [] xref: EC:5.3.1.14 xref: GO:0008740 "molecular_function:L-rhamnose isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00507 ! L-rhamnose relationship: has_input_compound UPa:UPC00507 {cardinality="1", is_alternate="False", is_primary="True"} ! L-rhamnose relationship: has_output_compound UPa:UPC00861 ! L-rhamnulose relationship: has_output_compound UPa:UPC00861 {cardinality="1", is_alternate="False", is_primary="True"} ! L-rhamnulose relationship: part_of UPa:ULS00288 ! glycerone phosphate from L-rhamnose relationship: part_of UPa:ULS00288 {cardinality="1", order="1"} ! glycerone phosphate from L-rhamnose [Term] id: UPa:UER00602 name: glycerone phosphate from L-rhamnose: step 2/3 namespace: enzymatic_reaction def: "1 ATP + 1 L-rhamnulose => 1 ADP + 1 L-rhamnulose 1-phosphate." [] xref: EC:2.7.1.5 xref: GO:0008993 "molecular_function:rhamnulokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00861 {cardinality="1", is_alternate="False", is_primary="True"} ! L-rhamnulose relationship: has_input_compound UPa:UPC00861 ! L-rhamnulose relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC01131 ! L-rhamnulose 1-phosphate relationship: has_output_compound UPa:UPC01131 {cardinality="1", is_alternate="False", is_primary="True"} ! L-rhamnulose 1-phosphate relationship: part_of UPa:ULS00288 ! glycerone phosphate from L-rhamnose relationship: part_of UPa:ULS00288 {cardinality="1", order="2"} ! glycerone phosphate from L-rhamnose [Term] id: UPa:UER00603 name: glycerone phosphate from L-rhamnose: step 3/3 namespace: enzymatic_reaction def: "1 L-rhamnulose 1-phosphate => 1 L-lactaldehyde + 1 glycerone phosphate." [] xref: EC:4.1.2.19 xref: GO:0008994 "molecular_function:rhamnulose-1-phosphate aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01131 {cardinality="1", is_alternate="False", is_primary="True"} ! L-rhamnulose 1-phosphate relationship: has_input_compound UPa:UPC01131 ! L-rhamnulose 1-phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00424 ! L-lactaldehyde relationship: has_output_compound UPa:UPC00424 {cardinality="1", is_alternate="False", is_primary="False"} ! L-lactaldehyde relationship: part_of UPa:ULS00288 ! glycerone phosphate from L-rhamnose relationship: part_of UPa:ULS00288 {cardinality="1", order="3"} ! glycerone phosphate from L-rhamnose [Term] id: UPa:UER00604 name: lactose 6-phosphate from lactose (PTS route): step 1/1 namespace: enzymatic_reaction def: "1 lactose + 1 protein N(pi)-phospho-L-histidine => 1 lactose 6-phosphate + 1 protein-L-histidine." [] xref: EC:2.7.1.69 xref: GO:0008982 "molecular_function:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00243 ! lactose relationship: has_input_compound UPa:UPC00243 {cardinality="1", is_alternate="False", is_primary="True"} ! lactose relationship: has_input_compound UPa:UPC04261 {cardinality="1", is_alternate="False", is_primary="False"} ! protein N(pi)-phospho-L-histidine relationship: has_input_compound UPa:UPC04261 ! protein N(pi)-phospho-L-histidine relationship: has_output_compound UPa:UPC00615 ! protein-L-histidine relationship: has_output_compound UPa:UPC00615 {cardinality="1", is_alternate="False", is_primary="False"} ! protein-L-histidine relationship: has_output_compound UPa:UPC05396 {cardinality="1", is_alternate="False", is_primary="True"} ! lactose 6-phosphate relationship: has_output_compound UPa:UPC05396 ! lactose 6-phosphate relationship: part_of UPa:ULS00289 ! lactose 6-phosphate from lactose (PTS route) relationship: part_of UPa:ULS00289 {cardinality="1", order="1"} ! lactose 6-phosphate from lactose (PTS route) [Term] id: UPa:UER00605 name: D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 lactose 6-phosphate => 1 D-galactose 6-phosphate + 1 beta-D-glucose." [] xref: EC:3.2.1.85 xref: GO:0033920 "molecular_function:6-phospho-beta-galactosidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC05396 ! lactose 6-phosphate relationship: has_input_compound UPa:UPC05396 {cardinality="1", is_alternate="False", is_primary="True"} ! lactose 6-phosphate relationship: has_output_compound UPa:UPC00221 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-D-glucose relationship: has_output_compound UPa:UPC00221 ! beta-D-glucose relationship: has_output_compound UPa:UPC01113 ! D-galactose 6-phosphate relationship: has_output_compound UPa:UPC01113 {cardinality="1", is_alternate="False", is_primary="True"} ! D-galactose 6-phosphate relationship: part_of UPa:ULS00290 ! D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate relationship: part_of UPa:ULS00290 {cardinality="1", order="1"} ! D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate [Term] id: UPa:UER00606 name: GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate: step 1/3 namespace: enzymatic_reaction def: "1 ATP + 1 D-glycero-alpha-D-manno-heptose 7-phosphate => 1 ADP + 1 D-glycero-alpha-D-manno-heptose 1,7-diphosphate." [] xref: EC:2.7.1.168 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC19878 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: has_input_compound UPa:UPC19878 ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC19879 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycero-alpha-D-manno-heptose 1,7-diphosphate relationship: has_output_compound UPa:UPC19879 ! D-glycero-alpha-D-manno-heptose 1,7-diphosphate relationship: part_of UPa:ULS00291 {cardinality="1", order="1"} ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate relationship: part_of UPa:ULS00291 ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate [Term] id: UPa:UER00607 name: GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate: step 2/3 namespace: enzymatic_reaction def: "1 D-glycero-alpha-D-manno-heptose 1,7-diphosphate + 1 H(2)O => 1 D-glycero-alpha-D-manno-heptose 1-phosphate + 1 phosphate." [] xref: EC:3.1.3.83 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC19879 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycero-alpha-D-manno-heptose 1,7-diphosphate relationship: has_input_compound UPa:UPC19879 ! D-glycero-alpha-D-manno-heptose 1,7-diphosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC19880 ! D-glycero-alpha-D-manno-heptose 1-phosphate relationship: has_output_compound UPa:UPC19880 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycero-alpha-D-manno-heptose 1-phosphate relationship: part_of UPa:ULS00291 {cardinality="1", order="2"} ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate relationship: part_of UPa:ULS00291 ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate [Term] id: UPa:UER00608 name: GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate: step 3/3 namespace: enzymatic_reaction def: "1 D-glycero-alpha-D-manno-heptose 1-phosphate + 1 GTP => 1 GDP-D-glycero-alpha-D-manno-heptose + 1 diphosphate." [] xref: EC:2.7.7.71 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00044 {cardinality="1", is_alternate="False", is_primary="False"} ! GTP relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC19880 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycero-alpha-D-manno-heptose 1-phosphate relationship: has_input_compound UPa:UPC19880 ! D-glycero-alpha-D-manno-heptose 1-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC19881 ! GDP-D-glycero-alpha-D-manno-heptose relationship: has_output_compound UPa:UPC19881 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-D-glycero-alpha-D-manno-heptose relationship: part_of UPa:ULS00291 ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate relationship: part_of UPa:ULS00291 {cardinality="1", order="3"} ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate [Term] id: UPa:UER00609 name: cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 1/2 namespace: enzymatic_reaction def: "1 2-phospho-D-glycerate + 1 ATP => 1 2,3-bisphospho-D-glycerate + 1 ADP." [] xref: EC:2.7.2 xref: GO:0016774 "molecular_function:phosphotransferase activity, carboxyl group as acceptor" xref: GO:0036357 "molecular_function:2-phosphoglycerate kinase activity" xref: GO:0043744 "molecular_function:N2-acetyl-L-aminoadipate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00631 ! 2-phospho-D-glycerate relationship: has_input_compound UPa:UPC00631 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-phospho-D-glycerate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC01159 ! 2,3-bisphospho-D-glycerate relationship: has_output_compound UPa:UPC01159 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,3-bisphospho-D-glycerate relationship: part_of UPa:ULS00292 ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate relationship: part_of UPa:ULS00292 {cardinality="1", order="1"} ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate [Term] id: UPa:UER00610 name: cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 2/2 namespace: enzymatic_reaction def: "1 2,3-bisphospho-D-glycerate + 1 ATP => 1 ADP + 1 cyclic 2,3-diphosphoglycerate + 1 phosphate." [] xref: EC:4.6.1 xref: GO:0036356 "molecular_function:cyclic 2,3-diphosphoglycerate synthetase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01159 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,3-bisphospho-D-glycerate relationship: has_input_compound UPa:UPC01159 ! 2,3-bisphospho-D-glycerate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC06189 ! cyclic 2,3-diphosphoglycerate relationship: has_output_compound UPa:UPC06189 {cardinality="1", is_alternate="False", is_primary="True"} ! cyclic 2,3-diphosphoglycerate relationship: part_of UPa:ULS00292 {cardinality="1", order="2"} ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate relationship: part_of UPa:ULS00292 ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate [Term] id: UPa:UER00611 name: (S)-lactate from pyruvate: step 1/1 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 pyruvate => 1 (S)-lactate + 1 NAD(+)." [] xref: EC:1.1.1.27 xref: GO:0004459 "molecular_function:L-lactate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00186 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-lactate relationship: has_output_compound UPa:UPC00186 ! (S)-lactate relationship: part_of UPa:ULS00293 {cardinality="1", order="1"} ! (S)-lactate from pyruvate relationship: part_of UPa:ULS00293 ! (S)-lactate from pyruvate [Term] id: UPa:UER00612 name: CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3 namespace: enzymatic_reaction def: "1 acyl-CoA + 1 sn-glycerol 3-phosphate => 1 1-acyl-sn-glycerol 3-phosphate + 1 CoA." [] xref: EC:2.3.1.15 xref: GO:0004366 "molecular_function:glycerol-3-phosphate O-acyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00040 ! acyl-CoA relationship: has_input_compound UPa:UPC00040 {cardinality="1", is_alternate="False", is_primary="False"} ! acyl-CoA relationship: has_input_compound UPa:UPC00093 {cardinality="1", is_alternate="False", is_primary="True"} ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00681 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-acyl-sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00681 ! 1-acyl-sn-glycerol 3-phosphate relationship: part_of UPa:ULS00294 {cardinality="1", order="1"} ! CDP-diacylglycerol from sn-glycerol 3-phosphate relationship: part_of UPa:ULS00294 ! CDP-diacylglycerol from sn-glycerol 3-phosphate [Term] id: UPa:UER00613 name: CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3 namespace: enzymatic_reaction def: "1 1-acyl-sn-glycerol 3-phosphate + 1 acyl-CoA => 1 CoA + 1 phosphatidate." [] xref: EC:2.3.1.51 xref: GO:0003841 "molecular_function:1-acylglycerol-3-phosphate O-acyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00040 ! acyl-CoA relationship: has_input_compound UPa:UPC00040 {cardinality="1", is_alternate="False", is_primary="False"} ! acyl-CoA relationship: has_input_compound UPa:UPC00681 ! 1-acyl-sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00681 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-acyl-sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00416 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphatidate relationship: has_output_compound UPa:UPC00416 ! phosphatidate relationship: part_of UPa:ULS00294 {cardinality="1", order="2"} ! CDP-diacylglycerol from sn-glycerol 3-phosphate relationship: part_of UPa:ULS00294 ! CDP-diacylglycerol from sn-glycerol 3-phosphate [Term] id: UPa:UER00614 name: CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3 namespace: enzymatic_reaction def: "1 CTP + 1 phosphatidate => 1 CDP-diacylglycerol + 1 diphosphate." [] xref: EC:2.7.7.41 xref: GO:0004605 "molecular_function:phosphatidate cytidylyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00063 {cardinality="1", is_alternate="False", is_primary="False"} ! CTP relationship: has_input_compound UPa:UPC00416 ! phosphatidate relationship: has_input_compound UPa:UPC00416 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphatidate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00269 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: part_of UPa:ULS00294 {cardinality="1", order="3"} ! CDP-diacylglycerol from sn-glycerol 3-phosphate relationship: part_of UPa:ULS00294 ! CDP-diacylglycerol from sn-glycerol 3-phosphate [Term] id: UPa:UER00615 name: phosphatidylethanolamine from CDP-diacylglycerol: step 1/2 namespace: enzymatic_reaction def: "1 CDP-diacylglycerol + 1 L-serine => 1 CMP + 1 phosphatidylserine." [] xref: EC:2.7.8.8 xref: GO:0003882 "molecular_function:CDP-diacylglycerol-serine O-phosphatidyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="False"} ! L-serine relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC00269 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-diacylglycerol relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="False"} ! CMP relationship: has_output_compound UPa:UPC02737 ! phosphatidylserine relationship: has_output_compound UPa:UPC02737 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphatidylserine relationship: part_of UPa:ULS00295 {cardinality="1", order="1"} ! phosphatidylethanolamine from CDP-diacylglycerol relationship: part_of UPa:ULS00295 ! phosphatidylethanolamine from CDP-diacylglycerol [Term] id: UPa:UER00616 name: phosphatidylethanolamine from CDP-diacylglycerol: step 2/2 namespace: enzymatic_reaction def: "1 phosphatidylserine => 1 CO(2) + 1 phosphatidylethanolamine." [] xref: EC:4.1.1.65 xref: GO:0004609 "molecular_function:phosphatidylserine decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC02737 ! phosphatidylserine relationship: has_input_compound UPa:UPC02737 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphatidylserine relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00350 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphatidylethanolamine relationship: has_output_compound UPa:UPC00350 ! phosphatidylethanolamine relationship: part_of UPa:ULS00295 {cardinality="1", order="2"} ! phosphatidylethanolamine from CDP-diacylglycerol relationship: part_of UPa:ULS00295 ! phosphatidylethanolamine from CDP-diacylglycerol [Term] id: UPa:UER00617 name: acetate and pyruvate from L-glutamate: step 1/4 namespace: enzymatic_reaction def: "1 L-glutamate => 1 (2S,3S)-3-methyl-L-aspartate." [] xref: EC:5.4.99.1 xref: GO:0050097 "molecular_function:methylaspartate mutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC03618 ! (2S,3S)-3-methyl-L-aspartate relationship: has_output_compound UPa:UPC03618 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S,3S)-3-methyl-L-aspartate relationship: part_of UPa:ULS00296 {cardinality="1", order="1"} ! acetate and pyruvate from L-glutamate relationship: part_of UPa:ULS00296 ! acetate and pyruvate from L-glutamate [Term] id: UPa:UER00618 name: acetate and pyruvate from L-glutamate: step 2/4 namespace: enzymatic_reaction def: "1 (2S,3S)-3-methyl-L-aspartate => 1 NH(3) + 1 mesaconate." [] xref: EC:4.3.1.2 xref: GO:0050096 "molecular_function:methylaspartate ammonia-lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03618 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S,3S)-3-methyl-L-aspartate relationship: has_input_compound UPa:UPC03618 ! (2S,3S)-3-methyl-L-aspartate relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC01732 ! mesaconate relationship: has_output_compound UPa:UPC01732 {cardinality="1", is_alternate="False", is_primary="True"} ! mesaconate relationship: part_of UPa:ULS00296 {cardinality="1", order="2"} ! acetate and pyruvate from L-glutamate relationship: part_of UPa:ULS00296 ! acetate and pyruvate from L-glutamate [Term] id: UPa:UER00619 name: acetate and pyruvate from L-glutamate: step 3/4 namespace: enzymatic_reaction def: "1 H(2)O + 1 mesaconate => 1 L-citramalate." [] xref: EC:4.2.1.34 xref: GO:0047510 "molecular_function:(S)-2-methylmalate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01732 ! mesaconate relationship: has_input_compound UPa:UPC01732 {cardinality="1", is_alternate="False", is_primary="True"} ! mesaconate relationship: has_output_compound UPa:UPC02614 {cardinality="1", is_alternate="False", is_primary="True"} ! L-citramalate relationship: has_output_compound UPa:UPC02614 ! L-citramalate relationship: part_of UPa:ULS00296 {cardinality="1", order="3"} ! acetate and pyruvate from L-glutamate relationship: part_of UPa:ULS00296 ! acetate and pyruvate from L-glutamate [Term] id: UPa:UER00620 name: acetate and pyruvate from L-glutamate: step 4/4 namespace: enzymatic_reaction def: "1 L-citramalate => 1 acetate + 1 pyruvate." [] xref: EC:4.1.3.22 xref: GO:0047776 "molecular_function:citramalate lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC02614 ! L-citramalate relationship: has_input_compound UPa:UPC02614 {cardinality="1", is_alternate="False", is_primary="True"} ! L-citramalate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="True"} ! acetate relationship: part_of UPa:ULS00296 ! acetate and pyruvate from L-glutamate relationship: part_of UPa:ULS00296 {cardinality="1", order="4"} ! acetate and pyruvate from L-glutamate [Term] id: UPa:UER00621 name: formate from formaldehyde (glutathione route): step 1/3 namespace: enzymatic_reaction def: "1 formaldehyde + 1 glutathione => 1 S-(hydroxymethyl)glutathione." [] xref: EC:4.4.1.22 xref: GO:0051907 "molecular_function:S-(hydroxymethyl)glutathione synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00051 ! glutathione relationship: has_input_compound UPa:UPC00051 {cardinality="1", is_alternate="False", is_primary="False"} ! glutathione relationship: has_input_compound UPa:UPC00067 ! formaldehyde relationship: has_input_compound UPa:UPC00067 {cardinality="1", is_alternate="False", is_primary="True"} ! formaldehyde relationship: has_output_compound UPa:UPC14180 ! S-(hydroxymethyl)glutathione relationship: has_output_compound UPa:UPC14180 {cardinality="1", is_alternate="False", is_primary="True"} ! S-(hydroxymethyl)glutathione relationship: part_of UPa:ULS00297 ! formate from formaldehyde (glutathione route) relationship: part_of UPa:ULS00297 {cardinality="1", order="1"} ! formate from formaldehyde (glutathione route) [Term] id: UPa:UER00622 name: formate from formaldehyde (glutathione route): step 2/3 namespace: enzymatic_reaction def: "S-(hydroxymethyl)glutathione + [NAD(+) or NADP(+)] => H(+) + S-formylglutathione + [NADH or NADPH]." [] xref: EC:1.1.1.284 xref: GO:0051903 "molecular_function:S-(hydroxymethyl)glutathione dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00971 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00972 ! None relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC14180 ! S-(hydroxymethyl)glutathione relationship: has_input_compound UPa:UPC14180 {cardinality="1", is_alternate="False", is_primary="True"} ! S-(hydroxymethyl)glutathione relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC01031 {cardinality="1", is_alternate="False", is_primary="True"} ! S-formylglutathione relationship: has_output_compound UPa:UPC01031 ! S-formylglutathione relationship: part_of UPa:ULS00297 ! formate from formaldehyde (glutathione route) relationship: part_of UPa:ULS00297 {cardinality="1", order="2"} ! formate from formaldehyde (glutathione route) [Term] id: UPa:UER00623 name: formate from formaldehyde (glutathione route): step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 S-formylglutathione => 1 formate + 1 glutathione." [] xref: EC:3.1.2.12 xref: GO:0018738 "molecular_function:S-formylglutathione hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01031 {cardinality="1", is_alternate="False", is_primary="True"} ! S-formylglutathione relationship: has_input_compound UPa:UPC01031 ! S-formylglutathione relationship: has_output_compound UPa:UPC00051 {cardinality="1", is_alternate="False", is_primary="False"} ! glutathione relationship: has_output_compound UPa:UPC00051 ! glutathione relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="True"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: part_of UPa:ULS00297 ! formate from formaldehyde (glutathione route) relationship: part_of UPa:ULS00297 {cardinality="1", order="3"} ! formate from formaldehyde (glutathione route) [Term] id: UPa:UER00624 name: L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3 namespace: enzymatic_reaction def: "1 L-fucose => 1 L-fuculose." [] xref: EC:5.3.1.25 xref: GO:0008736 "molecular_function:L-fucose isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01019 {cardinality="1", is_alternate="False", is_primary="True"} ! L-fucose relationship: has_input_compound UPa:UPC01019 ! L-fucose relationship: has_output_compound UPa:UPC01721 {cardinality="1", is_alternate="False", is_primary="True"} ! L-fuculose relationship: has_output_compound UPa:UPC01721 ! L-fuculose relationship: part_of UPa:ULS00298 ! L-lactaldehyde and glycerone phosphate from L-fucose relationship: part_of UPa:ULS00298 {cardinality="1", order="1"} ! L-lactaldehyde and glycerone phosphate from L-fucose [Term] id: UPa:UER00625 name: L-lactaldehyde and glycerone phosphate from L-fucose: step 2/3 namespace: enzymatic_reaction def: "1 ATP + 1 L-fuculose => 1 ADP + 1 L-fuculose 1-phosphate." [] xref: EC:2.7.1.51 xref: GO:0008737 "molecular_function:L-fuculokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC01721 ! L-fuculose relationship: has_input_compound UPa:UPC01721 {cardinality="1", is_alternate="False", is_primary="True"} ! L-fuculose relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC01099 {cardinality="1", is_alternate="False", is_primary="True"} ! L-fuculose 1-phosphate relationship: has_output_compound UPa:UPC01099 ! L-fuculose 1-phosphate relationship: part_of UPa:ULS00298 ! L-lactaldehyde and glycerone phosphate from L-fucose relationship: part_of UPa:ULS00298 {cardinality="1", order="2"} ! L-lactaldehyde and glycerone phosphate from L-fucose [Term] id: UPa:UER00626 name: L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3 namespace: enzymatic_reaction def: "1 L-fuculose 1-phosphate => 1 L-lactaldehyde + 1 glycerone phosphate." [] xref: EC:4.1.2.17 xref: GO:0008738 "molecular_function:L-fuculose-phosphate aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01099 ! L-fuculose 1-phosphate relationship: has_input_compound UPa:UPC01099 {cardinality="1", is_alternate="False", is_primary="True"} ! L-fuculose 1-phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00424 ! L-lactaldehyde relationship: has_output_compound UPa:UPC00424 {cardinality="1", is_alternate="False", is_primary="True"} ! L-lactaldehyde relationship: part_of UPa:ULS00298 ! L-lactaldehyde and glycerone phosphate from L-fucose relationship: part_of UPa:ULS00298 {cardinality="1", order="3"} ! L-lactaldehyde and glycerone phosphate from L-fucose [Term] id: UPa:UER00627 name: 2,5-dioxopentanoate from D-glucarate: step 1/2 namespace: enzymatic_reaction def: "1 D-glucarate => 1 5-dehydro-4-deoxy-D-glucarate + 1 H(2)O." [] xref: EC:4.2.1.40 xref: GO:0008872 "molecular_function:glucarate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00818 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucarate relationship: has_input_compound UPa:UPC00818 ! D-glucarate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00679 ! 5-dehydro-4-deoxy-D-glucarate relationship: has_output_compound UPa:UPC00679 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-dehydro-4-deoxy-D-glucarate relationship: part_of UPa:ULS00299 ! 2,5-dioxopentanoate from D-glucarate relationship: part_of UPa:ULS00299 {cardinality="1", order="1"} ! 2,5-dioxopentanoate from D-glucarate [Term] id: UPa:UER00628 name: 2,5-dioxopentanoate from D-glucarate: step 2/2 namespace: enzymatic_reaction def: "1 5-dehydro-4-deoxy-D-glucarate => 1 2,5-dioxopentanoate + 1 CO(2) + 1 H(2)O." [] xref: EC:4.2.1.41 xref: GO:0047448 "molecular_function:5-dehydro-4-deoxyglucarate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00679 ! 5-dehydro-4-deoxy-D-glucarate relationship: has_input_compound UPa:UPC00679 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-dehydro-4-deoxy-D-glucarate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00433 ! 2,5-dioxopentanoate relationship: has_output_compound UPa:UPC00433 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,5-dioxopentanoate relationship: part_of UPa:ULS00299 ! 2,5-dioxopentanoate from D-glucarate relationship: part_of UPa:ULS00299 {cardinality="1", order="2"} ! 2,5-dioxopentanoate from D-glucarate [Term] id: UPa:UER00629 name: D-glycerate from galactarate: step 1/3 namespace: enzymatic_reaction def: "1 galactarate => 1 5-dehydro-4-deoxy-D-glucarate + 1 H(2)O." [] xref: EC:4.2.1.42 xref: GO:0008867 "molecular_function:galactarate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00879 ! galactarate relationship: has_input_compound UPa:UPC00879 {cardinality="1", is_alternate="False", is_primary="True"} ! galactarate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00679 ! 5-dehydro-4-deoxy-D-glucarate relationship: has_output_compound UPa:UPC00679 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-dehydro-4-deoxy-D-glucarate relationship: part_of UPa:ULS00300 {cardinality="1", order="1"} ! D-glycerate from galactarate relationship: part_of UPa:ULS00300 ! D-glycerate from galactarate [Term] id: UPa:UER00630 name: D-glycerate from galactarate: step 2/3 namespace: enzymatic_reaction def: "1 5-dehydro-4-deoxy-D-glucarate => 1 2-hydroxy-3-oxopropanoate + 1 pyruvate." [] xref: EC:4.1.2.20 xref: GO:0008672 "molecular_function:2-dehydro-3-deoxyglucarate aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00679 ! 5-dehydro-4-deoxy-D-glucarate relationship: has_input_compound UPa:UPC00679 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-dehydro-4-deoxy-D-glucarate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC01146 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxopropanoate relationship: has_output_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate relationship: part_of UPa:ULS00300 ! D-glycerate from galactarate relationship: part_of UPa:ULS00300 {cardinality="1", order="2"} ! D-glycerate from galactarate [Term] id: UPa:UER00631 name: D-glycerate from galactarate: step 3/3 namespace: enzymatic_reaction def: "2-hydroxy-3-oxopropanoate + H(+) + [NADH or NADPH] => D-glycerate + [NAD(+) or NADP(+)]." [] xref: EC:1.1.1.60 xref: GO:0008679 "molecular_function:2-hydroxy-3-oxopropionate reductase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00973 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00974 ! None relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate relationship: has_input_compound UPa:UPC01146 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxopropanoate relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: part_of UPa:ULS00300 ! D-glycerate from galactarate relationship: part_of UPa:ULS00300 {cardinality="1", order="3"} ! D-glycerate from galactarate [Term] id: UPa:UER00632 name: uridine from cytidine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 cytidine => 1 NH(3) + 1 uridine." [] xref: EC:3.5.4.5 xref: GO:0004126 "molecular_function:cytidine deaminase activity" xref: GO:0047844 "molecular_function:deoxycytidine deaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00475 ! cytidine relationship: has_input_compound UPa:UPC00475 {cardinality="1", is_alternate="False", is_primary="True"} ! cytidine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00299 {cardinality="1", is_alternate="False", is_primary="True"} ! uridine relationship: has_output_compound UPa:UPC00299 ! uridine relationship: part_of UPa:ULS00301 ! uridine from cytidine relationship: part_of UPa:ULS00301 {cardinality="1", order="1"} ! uridine from cytidine [Term] id: UPa:UER00633 name: uracil from uridine (phosphorylase route): step 1/1 namespace: enzymatic_reaction def: "1 phosphate + 1 uridine => 1 alpha-D-ribose 1-phosphate + 1 uracil." [] xref: EC:2.4.2.3 xref: GO:0004850 "molecular_function:uridine phosphorylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00299 {cardinality="1", is_alternate="False", is_primary="True"} ! uridine relationship: has_input_compound UPa:UPC00299 ! uridine relationship: has_output_compound UPa:UPC00106 ! uracil relationship: has_output_compound UPa:UPC00106 {cardinality="1", is_alternate="False", is_primary="True"} ! uracil relationship: has_output_compound UPa:UPC00620 {cardinality="1", is_alternate="False", is_primary="False"} ! alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC00620 ! alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00302 ! uracil from uridine (phosphorylase route) relationship: part_of UPa:ULS00302 {cardinality="1", order="1"} ! uracil from uridine (phosphorylase route) [Term] id: UPa:UER00634 name: uracil from uridine (hydrolase route): step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 uridine => 1 D-ribose + 1 uracil." [] xref: EC:3.2.2.3 xref: GO:0045437 "molecular_function:uridine nucleosidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00299 {cardinality="1", is_alternate="False", is_primary="True"} ! uridine relationship: has_input_compound UPa:UPC00299 ! uridine relationship: has_output_compound UPa:UPC00106 ! uracil relationship: has_output_compound UPa:UPC00106 {cardinality="1", is_alternate="False", is_primary="True"} ! uracil relationship: has_output_compound UPa:UPC00121 ! D-ribose relationship: has_output_compound UPa:UPC00121 {cardinality="1", is_alternate="False", is_primary="False"} ! D-ribose relationship: part_of UPa:ULS00303 ! uracil from uridine (hydrolase route) relationship: part_of UPa:ULS00303 {cardinality="1", order="1"} ! uracil from uridine (hydrolase route) [Term] id: UPa:UER00635 name: uracil from cytosine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 cytosine => 1 NH(3) + 1 uracil." [] xref: EC:3.5.4.1 xref: GO:0004131 "molecular_function:cytosine deaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00380 ! cytosine relationship: has_input_compound UPa:UPC00380 {cardinality="1", is_alternate="False", is_primary="True"} ! cytosine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00106 ! uracil relationship: has_output_compound UPa:UPC00106 {cardinality="1", is_alternate="False", is_primary="True"} ! uracil relationship: part_of UPa:ULS00346 ! uracil from cytosine relationship: part_of UPa:ULS00346 {cardinality="1", order="1"} ! uracil from cytosine [Term] id: UPa:UER00636 name: UMP from uracil: step 1/1 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 uracil => 1 UMP + 1 diphosphate." [] xref: EC:2.4.2.9 xref: GO:0004845 "molecular_function:uracil phosphoribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00106 ! uracil relationship: has_input_compound UPa:UPC00106 {cardinality="1", is_alternate="False", is_primary="True"} ! uracil relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00105 ! UMP relationship: has_output_compound UPa:UPC00105 {cardinality="1", is_alternate="False", is_primary="True"} ! UMP relationship: part_of UPa:ULS00304 ! UMP from uracil relationship: part_of UPa:ULS00304 {cardinality="1", order="1"} ! UMP from uracil [Term] id: UPa:UER00637 name: UMP from uridine: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 uridine => 1 ADP + 1 UMP." [] xref: EC:2.7.1.48 xref: GO:0004849 "molecular_function:uridine kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00299 {cardinality="1", is_alternate="False", is_primary="True"} ! uridine relationship: has_input_compound UPa:UPC00299 ! uridine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00105 ! UMP relationship: has_output_compound UPa:UPC00105 {cardinality="1", is_alternate="False", is_primary="True"} ! UMP relationship: part_of UPa:ULS00305 ! UMP from uridine relationship: part_of UPa:ULS00305 {cardinality="1", order="1"} ! UMP from uridine [Term] id: UPa:UER00638 name: dTMP from thymine: step 1/2 namespace: enzymatic_reaction def: "1 2-deoxy-alpha-D-ribose 1-phosphate + 1 thymine => 1 phosphate + 1 thymidine." [] xref: EC:2.4.2.4 xref: GO:0009032 "molecular_function:thymidine phosphorylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00178 {cardinality="1", is_alternate="False", is_primary="True"} ! thymine relationship: has_input_compound UPa:UPC00178 ! thymine relationship: has_input_compound UPa:UPC00672 ! 2-deoxy-alpha-D-ribose 1-phosphate relationship: has_input_compound UPa:UPC00672 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-deoxy-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00214 {cardinality="1", is_alternate="False", is_primary="True"} ! thymidine relationship: has_output_compound UPa:UPC00214 ! thymidine relationship: part_of UPa:ULS00306 ! dTMP from thymine relationship: part_of UPa:ULS00306 {cardinality="1", order="1"} ! dTMP from thymine [Term] id: UPa:UER00639 name: dTMP from thymine: step 2/2 namespace: enzymatic_reaction def: "1 ATP + 1 thymidine => 1 ADP + 1 dTMP." [] xref: EC:2.7.1.21 xref: GO:0004797 "molecular_function:thymidine kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00214 ! thymidine relationship: has_input_compound UPa:UPC00214 {cardinality="1", is_alternate="False", is_primary="True"} ! thymidine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00364 ! dTMP relationship: has_output_compound UPa:UPC00364 {cardinality="1", is_alternate="False", is_primary="True"} ! dTMP relationship: part_of UPa:ULS00306 ! dTMP from thymine relationship: part_of UPa:ULS00306 {cardinality="1", order="2"} ! dTMP from thymine [Term] id: UPa:UER00640 name: CTP from cytidine: step 1/3 namespace: enzymatic_reaction def: "1 ATP + 1 cytidine => 1 ADP + 1 CMP." [] xref: EC:2.7.1.48 xref: GO:0004849 "molecular_function:uridine kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00475 {cardinality="1", is_alternate="False", is_primary="True"} ! cytidine relationship: has_input_compound UPa:UPC00475 ! cytidine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="True"} ! CMP relationship: part_of UPa:ULS00307 {cardinality="1", order="1"} ! CTP from cytidine relationship: part_of UPa:ULS00307 ! CTP from cytidine [Term] id: UPa:UER00641 name: CTP from cytidine: step 2/3 namespace: enzymatic_reaction def: "1 ATP + 1 CMP => 1 ADP + 1 CDP." [] xref: EC:2.7.4.14 xref: GO:0004127 "molecular_function:cytidylate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00055 ! CMP relationship: has_input_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="True"} ! CMP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00112 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP relationship: has_output_compound UPa:UPC00112 ! CDP relationship: part_of UPa:ULS00307 {cardinality="1", order="2"} ! CTP from cytidine relationship: part_of UPa:ULS00307 ! CTP from cytidine [Term] id: UPa:UER00642 name: CTP from cytidine: step 3/3 namespace: enzymatic_reaction def: "1 ATP + 1 CDP => 1 ADP + 1 CTP." [] xref: EC:2.7.4.6 xref: GO:0004550 "molecular_function:nucleoside diphosphate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00112 ! CDP relationship: has_input_compound UPa:UPC00112 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00063 ! CTP relationship: has_output_compound UPa:UPC00063 {cardinality="1", is_alternate="False", is_primary="True"} ! CTP relationship: part_of UPa:ULS00307 {cardinality="1", order="3"} ! CTP from cytidine relationship: part_of UPa:ULS00307 ! CTP from cytidine [Term] id: UPa:UER00643 name: malonate and urea from uracil: step 1/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 acceptor + 1 uracil => 1 barbiturate + 1 reduced acceptor." [] xref: EC:1.17.99.4 xref: GO:0050383 "molecular_function:uracil dehydrogenase activity" xref: GO:0052620 "molecular_function:thymine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00106 ! uracil relationship: has_input_compound UPa:UPC00106 {cardinality="1", is_alternate="False", is_primary="True"} ! uracil relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_output_compound UPa:UPC00813 {cardinality="1", is_alternate="False", is_primary="True"} ! barbiturate relationship: has_output_compound UPa:UPC00813 ! barbiturate relationship: part_of UPa:ULS00308 ! malonate and urea from uracil relationship: part_of UPa:ULS00308 {cardinality="1", order="1"} ! malonate and urea from uracil [Term] id: UPa:UER00644 name: malonate and urea from uracil: step 2/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 barbiturate => 1 3-oxo-3-ureidopropanoic acid." [] xref: EC:3.5.2.1 xref: GO:0047694 "molecular_function:barbiturase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00813 {cardinality="1", is_alternate="False", is_primary="True"} ! barbiturate relationship: has_input_compound UPa:UPC00813 ! barbiturate relationship: has_output_compound UPa:UPC15607 ! 3-oxo-3-ureidopropanoic acid relationship: has_output_compound UPa:UPC15607 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxo-3-ureidopropanoic acid relationship: part_of UPa:ULS00308 {cardinality="1", order="2"} ! malonate and urea from uracil relationship: part_of UPa:ULS00308 ! malonate and urea from uracil [Term] id: UPa:UER00645 name: malonate and urea from uracil: step 3/3 namespace: enzymatic_reaction def: "1 3-oxo-3-ureidopropanoic acid + 1 H(2)O => 1 malonate + 1 urea." [] xref: EC:3.5.1.95 xref: GO:0033970 "molecular_function:N-malonylurea hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC15607 ! 3-oxo-3-ureidopropanoic acid relationship: has_input_compound UPa:UPC15607 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxo-3-ureidopropanoic acid relationship: has_output_compound UPa:UPC00086 {cardinality="1", is_alternate="False", is_primary="True"} ! urea relationship: has_output_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00383 {cardinality="1", is_alternate="False", is_primary="True"} ! malonate relationship: has_output_compound UPa:UPC00383 ! malonate relationship: part_of UPa:ULS00308 {cardinality="1", order="3"} ! malonate and urea from uracil relationship: part_of UPa:ULS00308 ! malonate and urea from uracil [Term] id: UPa:UER00646 name: AMP from adenine: step 1/1 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 adenine => 1 AMP + 1 diphosphate." [] xref: EC:2.4.2.7 xref: GO:0003999 "molecular_function:adenine phosphoribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00147 ! adenine relationship: has_input_compound UPa:UPC00147 {cardinality="1", is_alternate="False", is_primary="True"} ! adenine relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="True"} ! AMP relationship: part_of UPa:ULS00309 {cardinality="1", order="1"} ! AMP from adenine relationship: part_of UPa:ULS00309 ! AMP from adenine [Term] id: UPa:UER00647 name: IMP from inosine: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 inosine => 1 ADP + 1 IMP." [] xref: EC:2.7.1.73 xref: GO:0008906 "molecular_function:inosine kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00294 ! inosine relationship: has_input_compound UPa:UPC00294 {cardinality="1", is_alternate="False", is_primary="True"} ! inosine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00130 {cardinality="1", is_alternate="False", is_primary="True"} ! IMP relationship: has_output_compound UPa:UPC00130 ! IMP relationship: part_of UPa:ULS00310 {cardinality="1", order="1"} ! IMP from inosine relationship: part_of UPa:ULS00310 ! IMP from inosine [Term] id: UPa:UER00648 name: IMP from hypoxanthine: step 1/1 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 hypoxanthine => 1 IMP + 1 diphosphate." [] xref: EC:2.4.2.8 xref: GO:0004422 "molecular_function:hypoxanthine phosphoribosyltransferase activity" xref: GO:0052657 "molecular_function:guanine phosphoribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00262 ! hypoxanthine relationship: has_input_compound UPa:UPC00262 {cardinality="1", is_alternate="False", is_primary="True"} ! hypoxanthine relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00130 {cardinality="1", is_alternate="False", is_primary="True"} ! IMP relationship: has_output_compound UPa:UPC00130 ! IMP relationship: part_of UPa:ULS00311 {cardinality="1", order="1"} ! IMP from hypoxanthine relationship: part_of UPa:ULS00311 ! IMP from hypoxanthine [Term] id: UPa:UER00649 name: AMP from ADP: step 1/1 namespace: enzymatic_reaction def: "2 ADP => 1 AMP + 1 ATP." [] xref: EC:2.7.4.3 xref: GO:0004017 "molecular_function:adenylate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00008 ! ADP relationship: has_input_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="True"} ! ADP relationship: has_output_compound UPa:UPC00002 ! ATP relationship: has_output_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="True"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: part_of UPa:ULS00312 {cardinality="1", order="1"} ! AMP from ADP relationship: part_of UPa:ULS00312 ! AMP from ADP [Term] id: UPa:UER00650 name: (S)-allantoin from urate: step 1/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 O(2) + 1 urate => 1 5-hydroxyisouric acid + 1 H(2)O(2)." [] xref: EC:1.7.3.3 xref: GO:0004846 "molecular_function:urate oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00366 ! urate relationship: has_input_compound UPa:UPC00366 {cardinality="1", is_alternate="False", is_primary="True"} ! urate relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC11821 ! 5-hydroxyisouric acid relationship: has_output_compound UPa:UPC11821 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-hydroxyisouric acid relationship: part_of UPa:ULS00313 ! (S)-allantoin from urate relationship: part_of UPa:ULS00313 {cardinality="1", order="1"} ! (S)-allantoin from urate [Term] id: UPa:UER00651 name: (S)-allantoin from urate: step 2/3 namespace: enzymatic_reaction def: "1 5-hydroxyisouric acid + 1 H(2)O => 1 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid." [] xref: EC:3.5.2.17 xref: GO:0033971 "molecular_function:hydroxyisourate hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC11821 ! 5-hydroxyisouric acid relationship: has_input_compound UPa:UPC11821 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-hydroxyisouric acid relationship: has_output_compound UPa:UPC12248 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid relationship: has_output_compound UPa:UPC12248 ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid relationship: part_of UPa:ULS00313 ! (S)-allantoin from urate relationship: part_of UPa:ULS00313 {cardinality="1", order="2"} ! (S)-allantoin from urate [Term] id: UPa:UER00652 name: (S)-allantoin from urate: step 3/3 namespace: enzymatic_reaction def: "1 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid => 1 (S)-allantoin + 1 CO(2)." [] xref: EC:4.1.1.97 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC12248 ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid relationship: has_input_compound UPa:UPC12248 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC02350 ! (S)-allantoin relationship: has_output_compound UPa:UPC02350 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-allantoin relationship: part_of UPa:ULS00313 {cardinality="1", order="3"} ! (S)-allantoin from urate relationship: part_of UPa:ULS00313 ! (S)-allantoin from urate [Term] id: UPa:UER00653 name: allantoate from (S)-allantoin: step 1/1 namespace: enzymatic_reaction def: "1 (S)-allantoin + 1 H(2)O => 1 allantoate." [] xref: EC:3.5.2.5 xref: GO:0004038 "molecular_function:allantoinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC02350 ! (S)-allantoin relationship: has_input_compound UPa:UPC02350 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-allantoin relationship: has_output_compound UPa:UPC00499 {cardinality="1", is_alternate="False", is_primary="True"} ! allantoate relationship: has_output_compound UPa:UPC00499 ! allantoate relationship: part_of UPa:ULS00314 {cardinality="1", order="1"} ! allantoate from (S)-allantoin relationship: part_of UPa:ULS00314 ! allantoate from (S)-allantoin [Term] id: UPa:UER00654 name: (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 allantoate => 1 (S)-ureidoglycolate + 1 urea." [] xref: EC:3.5.3.4 xref: GO:0004037 "molecular_function:allantoicase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00499 ! allantoate relationship: has_input_compound UPa:UPC00499 {cardinality="1", is_alternate="False", is_primary="True"} ! allantoate relationship: has_output_compound UPa:UPC00086 {cardinality="1", is_alternate="False", is_primary="False"} ! urea relationship: has_output_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00603 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: part_of UPa:ULS00315 {cardinality="1", order="1"} ! (S)-ureidoglycolate from allantoate (aminidohydrolase route) relationship: part_of UPa:ULS00315 ! (S)-ureidoglycolate from allantoate (aminidohydrolase route) [Term] id: UPa:UER00655 name: (S)-ureidoglycolate from allantoate (amidohydrolase route): step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 allantoate => 1 (S)-ureidoglycolate + 1 CO(2) + 1 NH(3)." [] xref: EC:3.5.3.9 xref: GO:0047652 "molecular_function:allantoate deiminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00499 ! allantoate relationship: has_input_compound UPa:UPC00499 {cardinality="1", is_alternate="False", is_primary="True"} ! allantoate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00603 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: part_of UPa:ULS00316 ! (S)-ureidoglycolate from allantoate (amidohydrolase route) relationship: part_of UPa:ULS00316 {cardinality="1", order="1"} ! (S)-ureidoglycolate from allantoate (amidohydrolase route) [Term] id: UPa:UER00656 name: glyoxylate from (S)-ureidoglycolate: step 1/1 namespace: enzymatic_reaction def: "1 (S)-ureidoglycolate + 1 H(2)O => 1 CO(2) + 2 NH(3) + 1 glyoxylate." [] xref: EC:3.5.1.116 xref: GO:0004848 "molecular_function:ureidoglycolate hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00603 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-ureidoglycolate relationship: has_input_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00048 {cardinality="1", is_alternate="False", is_primary="True"} ! glyoxylate relationship: has_output_compound UPa:UPC00048 ! glyoxylate relationship: part_of UPa:ULS00317 ! glyoxylate from (S)-ureidoglycolate relationship: part_of UPa:ULS00317 {cardinality="1", order="1"} ! glyoxylate from (S)-ureidoglycolate [Term] id: UPa:UER00657 name: oxalurate from (S)-ureidoglycolate: step 1/1 namespace: enzymatic_reaction def: "(S)-ureidoglycolate + [NAD(+) or NADP(+)] => H(+) + oxalurate + [NADH or NADPH]." [] xref: EC:1.1.1.154 xref: GO:0009040 "molecular_function:ureidoglycolate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00975 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00976 ! None relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00603 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-ureidoglycolate relationship: has_input_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00802 {cardinality="1", is_alternate="False", is_primary="True"} ! oxalurate relationship: has_output_compound UPa:UPC00802 ! oxalurate relationship: part_of UPa:ULS00318 ! oxalurate from (S)-ureidoglycolate relationship: part_of UPa:ULS00318 {cardinality="1", order="1"} ! oxalurate from (S)-ureidoglycolate [Term] id: UPa:UER00658 name: XMP from xanthine: step 1/1 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 xanthine => 1 XMP + 1 diphosphate." [] xref: EC:2.4.2.22 xref: GO:0000310 "molecular_function:xanthine phosphoribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00385 ! xanthine relationship: has_input_compound UPa:UPC00385 {cardinality="1", is_alternate="False", is_primary="True"} ! xanthine relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00655 {cardinality="1", is_alternate="False", is_primary="True"} ! XMP relationship: has_output_compound UPa:UPC00655 ! XMP relationship: part_of UPa:ULS00319 ! XMP from xanthine relationship: part_of UPa:ULS00319 {cardinality="1", order="1"} ! XMP from xanthine [Term] id: UPa:UER00659 name: AMP from adenosine: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 adenosine => 1 ADP + 1 AMP." [] xref: EC:2.7.1.20 xref: GO:0004001 "molecular_function:adenosine kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00212 ! adenosine relationship: has_input_compound UPa:UPC00212 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="True"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: part_of UPa:ULS00320 ! AMP from adenosine relationship: part_of UPa:ULS00320 {cardinality="1", order="1"} ! AMP from adenosine [Term] id: UPa:UER00660 name: xanthine from guanine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 guanine => 1 NH(3) + 1 xanthine." [] xref: EC:3.5.4.3 xref: GO:0008892 "molecular_function:guanine deaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00242 ! guanine relationship: has_input_compound UPa:UPC00242 {cardinality="1", is_alternate="False", is_primary="True"} ! guanine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00385 {cardinality="1", is_alternate="False", is_primary="True"} ! xanthine relationship: has_output_compound UPa:UPC00385 ! xanthine relationship: part_of UPa:ULS00321 {cardinality="1", order="1"} ! xanthine from guanine relationship: part_of UPa:ULS00321 ! xanthine from guanine [Term] id: UPa:UER00661 name: urate from hypoxanthine: step 1/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 hypoxanthine => 1 H(+) + 1 NADH + 1 xanthine." [] xref: EC:1.17.1.4 xref: GO:0004854 "molecular_function:xanthine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00262 {cardinality="1", is_alternate="False", is_primary="True"} ! hypoxanthine relationship: has_input_compound UPa:UPC00262 ! hypoxanthine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00385 {cardinality="1", is_alternate="False", is_primary="True"} ! xanthine relationship: has_output_compound UPa:UPC00385 ! xanthine relationship: part_of UPa:ULS00322 {cardinality="1", order="1"} ! urate from hypoxanthine relationship: part_of UPa:ULS00322 ! urate from hypoxanthine [Term] id: UPa:UER00662 name: urate from hypoxanthine: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 xanthine => 1 H(+) + 1 NADH + 1 urate." [] xref: EC:1.17.1.4 xref: GO:0004854 "molecular_function:xanthine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00385 {cardinality="1", is_alternate="False", is_primary="True"} ! xanthine relationship: has_input_compound UPa:UPC00385 ! xanthine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00366 {cardinality="1", is_alternate="False", is_primary="True"} ! urate relationship: has_output_compound UPa:UPC00366 ! urate relationship: part_of UPa:ULS00322 {cardinality="1", order="2"} ! urate from hypoxanthine relationship: part_of UPa:ULS00322 ! urate from hypoxanthine [Term] id: UPa:UER00663 name: IMP from AMP: step 1/1 namespace: enzymatic_reaction def: "1 AMP + 1 H(2)O => 1 IMP + 1 NH(3)." [] xref: EC:3.5.4.6 xref: GO:0003876 "molecular_function:AMP deaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00020 ! AMP relationship: has_input_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="True"} ! AMP relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00130 {cardinality="1", is_alternate="False", is_primary="True"} ! IMP relationship: has_output_compound UPa:UPC00130 ! IMP relationship: part_of UPa:ULS00323 ! IMP from AMP relationship: part_of UPa:ULS00323 {cardinality="1", order="1"} ! IMP from AMP [Term] id: UPa:UER00664 name: phosphatidate from CDP-diacylglycerol: step 1/1 namespace: enzymatic_reaction def: "1 CDP-diacylglycerol + 1 H(2)O => 1 CMP + 1 phosphatidate." [] xref: EC:3.6.1.26 xref: GO:0008715 "molecular_function:CDP-diacylglycerol diphosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: has_input_compound UPa:UPC00269 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="False"} ! CMP relationship: has_output_compound UPa:UPC00416 ! phosphatidate relationship: has_output_compound UPa:UPC00416 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphatidate relationship: part_of UPa:ULS00324 {cardinality="1", order="1"} ! phosphatidate from CDP-diacylglycerol relationship: part_of UPa:ULS00324 ! phosphatidate from CDP-diacylglycerol [Term] id: UPa:UER00665 name: dUMP from dCTP (dUTP route): step 1/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 dCTP => 1 NH(3) + 1 dUTP." [] xref: EC:3.5.4.13 xref: GO:0008829 "molecular_function:dCTP deaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00458 ! dCTP relationship: has_input_compound UPa:UPC00458 {cardinality="1", is_alternate="False", is_primary="True"} ! dCTP relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00460 ! dUTP relationship: has_output_compound UPa:UPC00460 {cardinality="1", is_alternate="False", is_primary="True"} ! dUTP relationship: part_of UPa:ULS00325 {cardinality="1", order="1"} ! dUMP from dCTP (dUTP route) relationship: part_of UPa:ULS00325 ! dUMP from dCTP (dUTP route) [Term] id: UPa:UER00666 name: dUMP from dCTP (dUTP route): step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 dUTP => 1 dUMP + 1 diphosphate." [] xref: EC:3.6.1.23 xref: GO:0004170 "molecular_function:dUTP diphosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00460 ! dUTP relationship: has_input_compound UPa:UPC00460 {cardinality="1", is_alternate="False", is_primary="True"} ! dUTP relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00365 {cardinality="1", is_alternate="False", is_primary="True"} ! dUMP relationship: has_output_compound UPa:UPC00365 ! dUMP relationship: part_of UPa:ULS00325 {cardinality="1", order="2"} ! dUMP from dCTP (dUTP route) relationship: part_of UPa:ULS00325 ! dUMP from dCTP (dUTP route) [Term] id: UPa:UER00667 name: dUMP from dCTP: step 1/1 namespace: enzymatic_reaction def: "2 H(2)O + 1 dCTP => 1 NH(3) + 1 dUMP + 1 diphosphate." [] xref: EC:3.5.4.30 xref: GO:0033973 "molecular_function:dCTP deaminase (dUMP-forming) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00458 ! dCTP relationship: has_input_compound UPa:UPC00458 {cardinality="1", is_alternate="False", is_primary="True"} ! dCTP relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00365 {cardinality="1", is_alternate="False", is_primary="True"} ! dUMP relationship: has_output_compound UPa:UPC00365 ! dUMP relationship: part_of UPa:ULS00326 ! dUMP from dCTP relationship: part_of UPa:ULS00326 {cardinality="1", order="1"} ! dUMP from dCTP [Term] id: UPa:UER00668 name: glycerone phosphate from glycerol (oxidative route): step 1/2 namespace: enzymatic_reaction def: "1 NAD(+) + 1 glycerol => 1 H(+) + 1 NADH + 1 glycerone." [] xref: EC:1.1.1.6 xref: GO:0008888 "molecular_function:glycerol dehydrogenase [NAD+] activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00116 ! glycerol relationship: has_input_compound UPa:UPC00116 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00184 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerone relationship: has_output_compound UPa:UPC00184 ! glycerone relationship: part_of UPa:ULS00327 ! glycerone phosphate from glycerol (oxidative route) relationship: part_of UPa:ULS00327 {cardinality="1", order="1"} ! glycerone phosphate from glycerol (oxidative route) [Term] id: UPa:UER00669 name: glycerone phosphate from glycerol (oxidative route): step 2/2 namespace: enzymatic_reaction def: "1 ATP + 1 glycerone => 1 ADP + 1 glycerone phosphate." [] xref: EC:2.7.1.29 xref: GO:0004371 "molecular_function:glycerone kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00184 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerone relationship: has_input_compound UPa:UPC00184 ! glycerone relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: part_of UPa:ULS00327 {cardinality="1", order="2"} ! glycerone phosphate from glycerol (oxidative route) relationship: part_of UPa:ULS00327 ! glycerone phosphate from glycerol (oxidative route) [Term] id: UPa:UER00670 name: propane-1,3-diol from glycerol (reductive route): step 1/2 namespace: enzymatic_reaction def: "1 glycerol => 1 3-hydroxypropanal + 1 H(2)O." [] xref: EC:4.2.1.30 xref: GO:0046405 "molecular_function:glycerol dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00116 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerol relationship: has_input_compound UPa:UPC00116 ! glycerol relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00969 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxypropanal relationship: has_output_compound UPa:UPC00969 ! 3-hydroxypropanal relationship: part_of UPa:ULS00328 {cardinality="1", order="1"} ! propane-1,3-diol from glycerol (reductive route) relationship: part_of UPa:ULS00328 ! propane-1,3-diol from glycerol (reductive route) [Term] id: UPa:UER00671 name: propane-1,3-diol from glycerol (reductive route): step 2/2 namespace: enzymatic_reaction def: "1 3-hydroxypropanal + 1 H(+) + 1 NADH => 1 NAD(+) + 1 propane-1,3-diol." [] xref: EC:1.1.1.202 xref: GO:0047516 "molecular_function:1,3-propanediol dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00969 ! 3-hydroxypropanal relationship: has_input_compound UPa:UPC00969 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxypropanal relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC02457 {cardinality="1", is_alternate="False", is_primary="True"} ! propane-1,3-diol relationship: has_output_compound UPa:UPC02457 ! propane-1,3-diol relationship: part_of UPa:ULS00328 {cardinality="1", order="2"} ! propane-1,3-diol from glycerol (reductive route) relationship: part_of UPa:ULS00328 ! propane-1,3-diol from glycerol (reductive route) [Term] id: UPa:UER00672 name: sn-glycerol 3-phosphate from glycerol: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 glycerol => 1 ADP + 1 sn-glycerol 3-phosphate." [] xref: EC:2.7.1.30 xref: GO:0004370 "molecular_function:glycerol kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00116 ! glycerol relationship: has_input_compound UPa:UPC00116 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerol relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00093 {cardinality="1", is_alternate="False", is_primary="True"} ! sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: part_of UPa:ULS00329 {cardinality="1", order="1"} ! sn-glycerol 3-phosphate from glycerol relationship: part_of UPa:ULS00329 ! sn-glycerol 3-phosphate from glycerol [Term] id: UPa:UER00673 name: glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1 namespace: enzymatic_reaction def: "1 Quinone + 1 sn-glycerol 3-phosphate => 1 Hydroquinone + 1 glycerone phosphate." [] xref: EC:1.1.5.3 xref: GO:0004368 "molecular_function:glycerol-3-phosphate dehydrogenase activity" xref: GO:0052590 "molecular_function:sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity" xref: GO:0052591 "molecular_function:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00093 {cardinality="1", is_alternate="False", is_primary="True"} ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC15602 {cardinality="1", is_alternate="False", is_primary="False"} ! Quinone relationship: has_input_compound UPa:UPC15602 ! Quinone relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerone phosphate relationship: has_output_compound UPa:UPC15603 {cardinality="1", is_alternate="False", is_primary="False"} ! Hydroquinone relationship: has_output_compound UPa:UPC15603 ! Hydroquinone relationship: part_of UPa:ULS00330 {cardinality="1", order="1"} ! glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route) relationship: part_of UPa:ULS00330 ! glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route) [Term] id: UPa:UER00674 name: glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1 namespace: enzymatic_reaction def: "1 Quinone + 1 sn-glycerol 3-phosphate => 1 Hydroquinone + 1 glycerone phosphate." [] xref: EC:1.1.5.3 xref: GO:0004368 "molecular_function:glycerol-3-phosphate dehydrogenase activity" xref: GO:0052590 "molecular_function:sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity" xref: GO:0052591 "molecular_function:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00093 {cardinality="1", is_alternate="False", is_primary="True"} ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC15602 {cardinality="1", is_alternate="False", is_primary="False"} ! Quinone relationship: has_input_compound UPa:UPC15602 ! Quinone relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerone phosphate relationship: has_output_compound UPa:UPC15603 {cardinality="1", is_alternate="False", is_primary="False"} ! Hydroquinone relationship: has_output_compound UPa:UPC15603 ! Hydroquinone relationship: part_of UPa:ULS00331 {cardinality="1", order="1"} ! glycerone phosphate from sn-glycerol 3-phosphate (aerobic route) relationship: part_of UPa:ULS00331 ! glycerone phosphate from sn-glycerol 3-phosphate (aerobic route) [Term] id: UPa:UER00675 name: (R)-lactate from methylglyoxal: step 1/2 namespace: enzymatic_reaction def: "1 glutathione + 1 methylglyoxal => 1 (R)-S-lactoylglutathione." [] xref: EC:4.4.1.5 xref: GO:0004462 "molecular_function:lactoylglutathione lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00051 ! glutathione relationship: has_input_compound UPa:UPC00051 {cardinality="1", is_alternate="False", is_primary="False"} ! glutathione relationship: has_input_compound UPa:UPC00546 {cardinality="1", is_alternate="False", is_primary="True"} ! methylglyoxal relationship: has_input_compound UPa:UPC00546 ! methylglyoxal relationship: has_output_compound UPa:UPC03451 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-S-lactoylglutathione relationship: has_output_compound UPa:UPC03451 ! (R)-S-lactoylglutathione relationship: part_of UPa:ULS00332 ! (R)-lactate from methylglyoxal relationship: part_of UPa:ULS00332 {cardinality="1", order="1"} ! (R)-lactate from methylglyoxal [Term] id: UPa:UER00676 name: (R)-lactate from methylglyoxal: step 2/2 namespace: enzymatic_reaction def: "1 (R)-S-lactoylglutathione + 1 H(2)O => 1 (R)-lactate + 1 glutathione." [] xref: EC:3.1.2.6 xref: GO:0004416 "molecular_function:hydroxyacylglutathione hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC03451 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-S-lactoylglutathione relationship: has_input_compound UPa:UPC03451 ! (R)-S-lactoylglutathione relationship: has_output_compound UPa:UPC00051 {cardinality="1", is_alternate="False", is_primary="False"} ! glutathione relationship: has_output_compound UPa:UPC00051 ! glutathione relationship: has_output_compound UPa:UPC00256 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-lactate relationship: has_output_compound UPa:UPC00256 ! (R)-lactate relationship: part_of UPa:ULS00332 ! (R)-lactate from methylglyoxal relationship: part_of UPa:ULS00332 {cardinality="1", order="2"} ! (R)-lactate from methylglyoxal [Term] id: UPa:UER00677 name: (R,R)-butane-2,3-diol from pyruvate: step 1/3 namespace: enzymatic_reaction def: "2 pyruvate => 1 (S)-2-acetolactate + 1 CO(2)." [] xref: EC:2.2.1.6 xref: GO:0003984 "molecular_function:acetolactate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC06010 ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC06010 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetolactate relationship: part_of UPa:ULS00333 {cardinality="1", order="1"} ! (R,R)-butane-2,3-diol from pyruvate relationship: part_of UPa:ULS00333 ! (R,R)-butane-2,3-diol from pyruvate [Term] id: UPa:UER00678 name: (R,R)-butane-2,3-diol from pyruvate: step 2/3 namespace: enzymatic_reaction def: "1 (S)-2-acetolactate => 1 (R)-acetoin + 1 CO(2)." [] xref: EC:4.1.1.5 xref: GO:0047605 "molecular_function:acetolactate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC06010 ! (S)-2-acetolactate relationship: has_input_compound UPa:UPC06010 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00810 ! (R)-acetoin relationship: has_output_compound UPa:UPC00810 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-acetoin relationship: part_of UPa:ULS00333 {cardinality="1", order="2"} ! (R,R)-butane-2,3-diol from pyruvate relationship: part_of UPa:ULS00333 ! (R,R)-butane-2,3-diol from pyruvate [Term] id: UPa:UER00679 name: (R,R)-butane-2,3-diol from pyruvate: step 3/3 namespace: enzymatic_reaction def: "1 (R)-acetoin + 1 H(+) + 1 NADH => 1 (R,R)-butane-2,3-diol + 1 NAD(+)." [] xref: EC:1.1.1.4 xref: GO:0000721 "molecular_function:(R,R)-butanediol dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00810 ! (R)-acetoin relationship: has_input_compound UPa:UPC00810 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-acetoin relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC03044 ! (R,R)-butane-2,3-diol relationship: has_output_compound UPa:UPC03044 {cardinality="1", is_alternate="False", is_primary="True"} ! (R,R)-butane-2,3-diol relationship: part_of UPa:ULS00333 ! (R,R)-butane-2,3-diol from pyruvate relationship: part_of UPa:ULS00333 {cardinality="1", order="3"} ! (R,R)-butane-2,3-diol from pyruvate [Term] id: UPa:UER00680 name: D-fructose 6-phosphate from N-acetylneuraminate: step 1/5 namespace: enzymatic_reaction def: "1 N-acetylneuraminate => 1 N-acetyl-D-mannosamine + 1 pyruvate." [] xref: EC:4.1.3.3 xref: GO:0008747 "molecular_function:N-acetylneuraminate lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00270 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetylneuraminate relationship: has_input_compound UPa:UPC00270 ! N-acetylneuraminate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_output_compound UPa:UPC00645 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-D-mannosamine relationship: has_output_compound UPa:UPC00645 ! N-acetyl-D-mannosamine relationship: part_of UPa:ULS00334 ! D-fructose 6-phosphate from N-acetylneuraminate relationship: part_of UPa:ULS00334 {cardinality="1", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate [Term] id: UPa:UER00681 name: D-fructose 6-phosphate from N-acetylneuraminate: step 2/5 namespace: enzymatic_reaction def: "1 ATP + 1 N-acetyl-D-mannosamine => 1 ADP + 1 N-acetyl-D-mannosamine 6-phosphate." [] xref: EC:2.7.1.60 xref: GO:0009384 "molecular_function:N-acylmannosamine kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00645 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-D-mannosamine relationship: has_input_compound UPa:UPC00645 ! N-acetyl-D-mannosamine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC04257 ! N-acetyl-D-mannosamine 6-phosphate relationship: has_output_compound UPa:UPC04257 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-D-mannosamine 6-phosphate relationship: part_of UPa:ULS00334 ! D-fructose 6-phosphate from N-acetylneuraminate relationship: part_of UPa:ULS00334 {cardinality="1", order="2"} ! D-fructose 6-phosphate from N-acetylneuraminate [Term] id: UPa:UER00682 name: D-fructose 6-phosphate from N-acetylneuraminate: step 3/5 namespace: enzymatic_reaction def: "1 N-acetyl-D-mannosamine 6-phosphate => 1 N-acetyl-D-glucosamine 6-phosphate." [] xref: EC:5.1.3.9 xref: GO:0047465 "molecular_function:N-acylglucosamine-6-phosphate 2-epimerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04257 ! N-acetyl-D-mannosamine 6-phosphate relationship: has_input_compound UPa:UPC04257 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-D-mannosamine 6-phosphate relationship: has_output_compound UPa:UPC00357 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00357 ! N-acetyl-D-glucosamine 6-phosphate relationship: part_of UPa:ULS00334 ! D-fructose 6-phosphate from N-acetylneuraminate relationship: part_of UPa:ULS00334 {cardinality="1", order="3"} ! D-fructose 6-phosphate from N-acetylneuraminate [Term] id: UPa:UER00683 name: D-fructose 6-phosphate from N-acetylneuraminate: step 4/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-acetyl-D-glucosamine 6-phosphate => 1 acetate + 1 alpha-D-glucosamine 6-phosphate." [] xref: EC:3.5.1.25 xref: GO:0008448 "molecular_function:N-acetylglucosamine-6-phosphate deacetylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00357 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-D-glucosamine 6-phosphate relationship: has_input_compound UPa:UPC00357 ! N-acetyl-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC00352 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: part_of UPa:ULS00334 ! D-fructose 6-phosphate from N-acetylneuraminate relationship: part_of UPa:ULS00334 {cardinality="1", order="4"} ! D-fructose 6-phosphate from N-acetylneuraminate [Term] id: UPa:UER00684 name: D-fructose 6-phosphate from N-acetylneuraminate: step 5/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 alpha-D-glucosamine 6-phosphate => 1 D-fructose 6-phosphate + 1 NH(3)." [] xref: EC:3.5.99.6 xref: GO:0004342 "molecular_function:glucosamine-6-phosphate deaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00352 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-glucosamine 6-phosphate relationship: has_input_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 6-phosphate relationship: part_of UPa:ULS00334 ! D-fructose 6-phosphate from N-acetylneuraminate relationship: part_of UPa:ULS00334 {cardinality="1", order="5"} ! D-fructose 6-phosphate from N-acetylneuraminate [Term] id: UPa:UER00685 name: crotonoyl-CoA from L-glutamate: step 2/5 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 FADH2 => 1 2-hydroxyglutarate + 1 FAD." [] xref: EC:1.1.99.2 xref: GO:0047545 "molecular_function:2-hydroxyglutarate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC01352 {cardinality="1", is_alternate="False", is_primary="False"} ! FADH2 relationship: has_input_compound UPa:UPC01352 ! FADH2 relationship: has_output_compound UPa:UPC00016 ! FAD relationship: has_output_compound UPa:UPC00016 {cardinality="1", is_alternate="False", is_primary="False"} ! FAD relationship: has_output_compound UPa:UPC02630 ! 2-hydroxyglutarate relationship: has_output_compound UPa:UPC02630 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxyglutarate relationship: part_of UPa:ULS00335 ! crotonoyl-CoA from L-glutamate relationship: part_of UPa:ULS00335 {cardinality="1", order="2"} ! crotonoyl-CoA from L-glutamate [Term] id: UPa:UER00686 name: crotonoyl-CoA from L-glutamate: step 3/5 namespace: enzymatic_reaction def: "1 2-hydroxyglutarate + 1 acetyl-CoA => 1 2-hydroxyglutaryl-CoA + 1 acetate." [] xref: EC:2.8.3.12 xref: GO:0018730 "molecular_function:glutaconate CoA-transferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC02630 ! 2-hydroxyglutarate relationship: has_input_compound UPa:UPC02630 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxyglutarate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC03058 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxyglutaryl-CoA relationship: has_output_compound UPa:UPC03058 ! 2-hydroxyglutaryl-CoA relationship: part_of UPa:ULS00335 {cardinality="1", order="3"} ! crotonoyl-CoA from L-glutamate relationship: part_of UPa:ULS00335 ! crotonoyl-CoA from L-glutamate [Term] id: UPa:UER00687 name: crotonoyl-CoA from L-glutamate: step 4/5 namespace: enzymatic_reaction def: "1 2-hydroxyglutaryl-CoA => 1 H(2)O + 1 glutaconyl-1-CoA." [] xref: EC:4.2.1 xref: GO:0008659 "molecular_function:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity" xref: GO:0016836 "molecular_function:hydro-lyase activity" xref: GO:0018807 "molecular_function:6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity" xref: GO:0018808 "molecular_function:trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity" xref: GO:0018809 "molecular_function:E-phenylitaconyl-CoA hydratase activity" xref: GO:0018810 "molecular_function:trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity" xref: GO:0018811 "molecular_function:cyclohex-1-ene-1-carboxyl-CoA hydratase activity" xref: GO:0018812 "molecular_function:3-hydroxyacyl-CoA dehydratase activity" xref: GO:0018813 "molecular_function:trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity" xref: GO:0018815 "molecular_function:3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity" xref: GO:0018816 "molecular_function:2-hydroxyisobutyrate dehydratase activity" xref: GO:0018817 "molecular_function:2-oxo-hept-3-ene-1,7-dioate hydratase activity" xref: GO:0034561 "molecular_function:1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity" xref: GO:0034578 "molecular_function:limonene 8-hydratase activity" xref: GO:0034581 "molecular_function:4-methyloct-2-enoyl-CoA hydratase activity" xref: GO:0034829 "molecular_function:2-hydroxydec-2,4-diene-1,10-dioate hydratase activity" xref: GO:0034839 "molecular_function:menth-2-enone hydratase activity" xref: GO:0034846 "molecular_function:naphthyl-2-methylene-succinyl-CoA lyase activity" xref: GO:0034856 "molecular_function:2-hydroxyhexa-2,4-dienoate hydratase activity" xref: GO:0034867 "molecular_function:2,4,4-trimethylpent-2-enoyl-CoA hydratase activity" xref: GO:0034890 "molecular_function:endosulfan diol hydrolyase (cyclizing) activity" xref: GO:0034904 "molecular_function:5-chloro-2-oxopent-4-enoate hydratase activity" xref: GO:0034917 "molecular_function:2-methylhex-2-enoyl-CoA hydratase activity" xref: GO:0034953 "molecular_function:perillyl-CoA hydratase activity" xref: GO:0043724 "molecular_function:2-keto-3-deoxygalactonate aldolase activity" xref: GO:0043725 "molecular_function:2-keto-3-deoxygluconate aldolase activity" xref: GO:0043956 "molecular_function:3-hydroxypropionyl-CoA dehydratase activity" xref: GO:0043960 "molecular_function:L-erythro-3-methylmalyl-CoA dehydratase activity" xref: GO:0046565 "molecular_function:3-dehydroshikimate dehydratase activity" xref: GO:0051909 "molecular_function:acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate" xref: GO:0052684 "molecular_function:L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity" xref: GO:0052855 "molecular_function:ADP-dependent NAD(P)H-hydrate dehydratase activity" xref: GO:0070497 "molecular_function:6-carboxy-5,6,7,8-tetrahydropterin synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03058 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxyglutaryl-CoA relationship: has_input_compound UPa:UPC03058 ! 2-hydroxyglutaryl-CoA relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC02411 ! glutaconyl-1-CoA relationship: has_output_compound UPa:UPC02411 {cardinality="1", is_alternate="False", is_primary="True"} ! glutaconyl-1-CoA relationship: part_of UPa:ULS00335 {cardinality="1", order="4"} ! crotonoyl-CoA from L-glutamate relationship: part_of UPa:ULS00335 ! crotonoyl-CoA from L-glutamate [Term] id: UPa:UER00688 name: crotonoyl-CoA from L-glutamate: step 5/5 namespace: enzymatic_reaction def: "1 glutaconyl-1-CoA => 1 CO(2) + 1 crotonoyl-CoA." [] xref: EC:4.1.1.70 xref: GO:0018801 "molecular_function:glutaconyl-CoA decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC02411 {cardinality="1", is_alternate="False", is_primary="True"} ! glutaconyl-1-CoA relationship: has_input_compound UPa:UPC02411 ! glutaconyl-1-CoA relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00877 {cardinality="1", is_alternate="False", is_primary="True"} ! crotonoyl-CoA relationship: has_output_compound UPa:UPC00877 ! crotonoyl-CoA relationship: part_of UPa:ULS00335 ! crotonoyl-CoA from L-glutamate relationship: part_of UPa:ULS00335 {cardinality="1", order="5"} ! crotonoyl-CoA from L-glutamate [Term] id: UPa:UER00689 name: L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route): step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 H(+) + 1 L-glutamine + 1 NADPH => 2 L-glutamate + 1 NADP(+)." [] xref: EC:1.4.1.13 xref: GO:0004355 "molecular_function:glutamate synthase (NADPH) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamine relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: part_of UPa:ULS00336 ! L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route) relationship: part_of UPa:ULS00336 {cardinality="1", order="1"} ! L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route) [Term] id: UPa:UER00690 name: L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 H(+) + 1 L-glutamine + 1 NADH => 2 L-glutamate + 1 NAD(+)." [] xref: EC:1.4.1.14 xref: GO:0016040 "molecular_function:glutamate synthase (NADH) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamine relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: part_of UPa:ULS00337 {cardinality="1", order="1"} ! L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route) relationship: part_of UPa:ULS00337 ! L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route) [Term] id: UPa:UER00691 name: L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route): step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 2 H(+) + 1 L-glutamine + 2 reduced ferredoxin => 2 L-glutamate + 2 oxidized ferredoxin." [] xref: EC:1.4.7.1 xref: GO:0016041 "molecular_function:glutamate synthase (ferredoxin) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamine relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00138 ! reduced ferredoxin relationship: has_input_compound UPa:UPC00138 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced ferredoxin relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00139 ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00139 {cardinality="1", is_alternate="False", is_primary="False"} ! oxidized ferredoxin relationship: part_of UPa:ULS00338 {cardinality="1", order="1"} ! L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route) relationship: part_of UPa:ULS00338 ! L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route) [Term] id: UPa:UER00692 name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3 namespace: enzymatic_reaction def: "1 CO(2) + 1 methanofuran + 1 reduced acceptor => 1 H(2)O + 1 N-formylmethanofuran + 1 acceptor." [] xref: EC:1.2.99.5 xref: GO:0018493 "molecular_function:formylmethanofuran dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="True"} ! CO(2) relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_input_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_input_compound UPa:UPC00030 ! reduced acceptor relationship: has_input_compound UPa:UPC00862 ! methanofuran relationship: has_input_compound UPa:UPC00862 {cardinality="1", is_alternate="False", is_primary="False"} ! methanofuran relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_output_compound UPa:UPC00028 ! acceptor relationship: has_output_compound UPa:UPC01001 {cardinality="1", is_alternate="False", is_primary="True"} ! N-formylmethanofuran relationship: has_output_compound UPa:UPC01001 ! N-formylmethanofuran relationship: part_of UPa:ULS00339 {cardinality="1", order="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2) relationship: part_of UPa:ULS00339 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2) [Term] id: UPa:UER00693 name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3 namespace: enzymatic_reaction def: "1 5,6,7,8-tetrahydromethanopterin + 1 N-formylmethanofuran => 1 N(5)-formyl-5,6,7,8-tetrahydromethanopterin + 1 methanofuran." [] xref: EC:2.3.1.101 xref: GO:0030270 "molecular_function:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01001 ! N-formylmethanofuran relationship: has_input_compound UPa:UPC01001 {cardinality="1", is_alternate="False", is_primary="True"} ! N-formylmethanofuran relationship: has_input_compound UPa:UPC01217 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC01217 ! 5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00862 ! methanofuran relationship: has_output_compound UPa:UPC00862 {cardinality="1", is_alternate="False", is_primary="False"} ! methanofuran relationship: has_output_compound UPa:UPC01274 {cardinality="1", is_alternate="False", is_primary="True"} ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01274 ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:ULS00339 {cardinality="1", order="2"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2) relationship: part_of UPa:ULS00339 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2) [Term] id: UPa:UER00694 name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3 namespace: enzymatic_reaction def: "1 H(+) + 1 N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 1 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + 1 H(2)O." [] xref: EC:3.5.4.27 xref: GO:0018759 "molecular_function:methenyltetrahydromethanopterin cyclohydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01274 {cardinality="1", is_alternate="False", is_primary="True"} ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC01274 ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04330 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:ULS00339 {cardinality="1", order="3"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2) relationship: part_of UPa:ULS00339 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2) [Term] id: UPa:UER00695 name: 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route): step 1/1 namespace: enzymatic_reaction def: "1 1,5-dihydro-coenzyme F(420) + 1 5,10-methenyl-5,6,7,8-tetrahydromethanopterin => 1 5,10-methylene-5,6,7,8-tetrahydromethanopterin + 1 coenzyme F420." [] xref: EC:1.5.98.1 xref: GO:0030268 "molecular_function:methylenetetrahydromethanopterin dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01080 {cardinality="1", is_alternate="False", is_primary="False"} ! 1,5-dihydro-coenzyme F(420) relationship: has_input_compound UPa:UPC01080 ! 1,5-dihydro-coenzyme F(420) relationship: has_input_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04330 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00876 ! coenzyme F420 relationship: has_output_compound UPa:UPC00876 {cardinality="1", is_alternate="False", is_primary="False"} ! coenzyme F420 relationship: has_output_compound UPa:UPC04377 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:ULS00340 {cardinality="1", order="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route) relationship: part_of UPa:ULS00340 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route) [Term] id: UPa:UER00696 name: 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (hydrogen route): step 1/1 namespace: enzymatic_reaction def: "1 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + 1 H(2) => 1 5,10-methylene-5,6,7,8-tetrahydromethanopterin + 1 H(+)." [] xref: EC:1.12.98.2 xref: GO:0047068 "molecular_function:N5,N10-methenyltetrahydromethanopterin hydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00282 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2) relationship: has_input_compound UPa:UPC00282 ! H(2) relationship: has_input_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04330 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC04377 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:ULS00341 {cardinality="1", order="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (hydrogen route) relationship: part_of UPa:ULS00341 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (hydrogen route) [Term] id: UPa:UER00697 name: methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 1/2 namespace: enzymatic_reaction def: "1 1,5-dihydro-coenzyme F(420) + 1 5,10-methylene-5,6,7,8-tetrahydromethanopterin => 1 5-methyl-5,6,7,8-tetrahydromethanopterin + 1 coenzyme F420." [] xref: EC:1.5.98.2 xref: GO:0018537 "molecular_function:coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01080 {cardinality="1", is_alternate="False", is_primary="False"} ! 1,5-dihydro-coenzyme F(420) relationship: has_input_compound UPa:UPC01080 ! 1,5-dihydro-coenzyme F(420) relationship: has_input_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04377 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00876 ! coenzyme F420 relationship: has_output_compound UPa:UPC00876 {cardinality="1", is_alternate="False", is_primary="False"} ! coenzyme F420 relationship: has_output_compound UPa:UPC04488 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-methyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04488 ! 5-methyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:ULS00342 {cardinality="1", order="1"} ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:ULS00342 ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin [Term] id: UPa:UER00698 name: methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2 namespace: enzymatic_reaction def: "1 5-methyl-5,6,7,8-tetrahydromethanopterin + 1 coenzyme M => 1 5,6,7,8-tetrahydromethanopterin + 1 methyl-coenzyme M." [] xref: EC:2.1.1.86 xref: GO:0030269 "molecular_function:tetrahydromethanopterin S-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03576 ! coenzyme M relationship: has_input_compound UPa:UPC03576 {cardinality="1", is_alternate="False", is_primary="False"} ! coenzyme M relationship: has_input_compound UPa:UPC04488 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-methyl-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04488 ! 5-methyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01217 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01217 ! 5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC03920 ! methyl-coenzyme M relationship: has_output_compound UPa:UPC03920 {cardinality="1", is_alternate="False", is_primary="True"} ! methyl-coenzyme M relationship: part_of UPa:ULS00342 {cardinality="1", order="2"} ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:ULS00342 ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin [Term] id: UPa:UER00699 name: methane from methyl-coenzyme M: step 1/1 namespace: enzymatic_reaction def: "1 coenzyme B + 1 methyl-coenzyme M => 1 coenzyme M-coenzyme B heterodisulfide + 1 methane." [] xref: EC:2.8.4.1 xref: GO:0050524 "molecular_function:coenzyme-B sulfoethylthiotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03920 {cardinality="1", is_alternate="False", is_primary="True"} ! methyl-coenzyme M relationship: has_input_compound UPa:UPC03920 ! methyl-coenzyme M relationship: has_input_compound UPa:UPC04628 ! coenzyme B relationship: has_input_compound UPa:UPC04628 {cardinality="1", is_alternate="False", is_primary="False"} ! coenzyme B relationship: has_output_compound UPa:UPC01438 {cardinality="1", is_alternate="False", is_primary="True"} ! methane relationship: has_output_compound UPa:UPC01438 ! methane relationship: has_output_compound UPa:UPC04832 {cardinality="1", is_alternate="False", is_primary="False"} ! coenzyme M-coenzyme B heterodisulfide relationship: has_output_compound UPa:UPC04832 ! coenzyme M-coenzyme B heterodisulfide relationship: part_of UPa:ULS00343 {cardinality="1", order="1"} ! methane from methyl-coenzyme M relationship: part_of UPa:ULS00343 ! methane from methyl-coenzyme M [Term] id: UPa:UER00700 name: coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1 namespace: enzymatic_reaction def: "1 coenzyme M-coenzyme B heterodisulfide + 1 dihydromethanophenazine => 1 coenzyme B + 1 coenzyme M + 1 methanophenazine." [] xref: EC:1.8.98.1 xref: GO:0051912 "molecular_function:CoB--CoM heterodisulfide reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04832 {cardinality="1", is_alternate="False", is_primary="True"} ! coenzyme M-coenzyme B heterodisulfide relationship: has_input_compound UPa:UPC04832 ! coenzyme M-coenzyme B heterodisulfide relationship: has_input_compound UPa:UPC11904 {cardinality="1", is_alternate="False", is_primary="False"} ! dihydromethanophenazine relationship: has_input_compound UPa:UPC11904 ! dihydromethanophenazine relationship: has_output_compound UPa:UPC03576 ! coenzyme M relationship: has_output_compound UPa:UPC03576 {cardinality="1", is_alternate="False", is_primary="True"} ! coenzyme M relationship: has_output_compound UPa:UPC04628 {cardinality="1", is_alternate="False", is_primary="True"} ! coenzyme B relationship: has_output_compound UPa:UPC04628 ! coenzyme B relationship: has_output_compound UPa:UPC11903 {cardinality="1", is_alternate="False", is_primary="False"} ! methanophenazine relationship: has_output_compound UPa:UPC11903 ! methanophenazine relationship: part_of UPa:ULS00344 {cardinality="1", order="1"} ! coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide relationship: part_of UPa:ULS00344 ! coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide [Term] id: UPa:UER00701 name: formate from formaldehyde (H(4)MPT route): step 1/5 namespace: enzymatic_reaction def: "1 5,6,7,8-tetrahydromethanopterin + 1 formaldehyde => 1 5,10-methylene-5,6,7,8-tetrahydromethanopterin + 1 H(2)O." [] xref: EC:4.3 xref: GO:0016840 "molecular_function:carbon-nitrogen lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00067 ! formaldehyde relationship: has_input_compound UPa:UPC00067 {cardinality="1", is_alternate="False", is_primary="True"} ! formaldehyde relationship: has_input_compound UPa:UPC01217 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC01217 ! 5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04377 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:ULS00345 {cardinality="1", order="1"} ! formate from formaldehyde (H(4)MPT route) relationship: part_of UPa:ULS00345 ! formate from formaldehyde (H(4)MPT route) [Term] id: UPa:UER00702 name: formate from formaldehyde (H(4)MPT route): step 2/5 namespace: enzymatic_reaction def: "1 5,10-methylene-5,6,7,8-tetrahydromethanopterin + 1 NADP(+) => 1 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + 1 NADPH." [] xref: EC:1.5.1 xref: GO:0004486 "molecular_function:methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity" xref: GO:0004753 "molecular_function:saccharopine dehydrogenase activity" xref: GO:0016646 "molecular_function:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor" xref: GO:0018529 "molecular_function:nitrilotriacetate monooxygenase activity" xref: GO:0044684 "molecular_function:dihydromethanopterin reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04377 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04330 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:ULS00345 {cardinality="1", order="2"} ! formate from formaldehyde (H(4)MPT route) relationship: part_of UPa:ULS00345 ! formate from formaldehyde (H(4)MPT route) [Term] id: UPa:UER00703 name: formate from formaldehyde (H(4)MPT route): step 3/5 namespace: enzymatic_reaction def: "1 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + 1 H(2)O => 1 H(+) + 1 N(5)-formyl-5,6,7,8-tetrahydromethanopterin." [] xref: EC:3.5.4.27 xref: GO:0018759 "molecular_function:methenyltetrahydromethanopterin cyclohydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04330 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC01274 {cardinality="1", is_alternate="False", is_primary="True"} ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01274 ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:ULS00345 {cardinality="1", order="3"} ! formate from formaldehyde (H(4)MPT route) relationship: part_of UPa:ULS00345 ! formate from formaldehyde (H(4)MPT route) [Term] id: UPa:UER00704 name: formate from formaldehyde (H(4)MPT route): step 4/5 namespace: enzymatic_reaction def: "1 N(5)-formyl-5,6,7,8-tetrahydromethanopterin + 1 methanofuran => 1 5,6,7,8-tetrahydromethanopterin + 1 N-formylmethanofuran." [] xref: EC:2.3.1.101 xref: GO:0030270 "molecular_function:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00862 {cardinality="1", is_alternate="False", is_primary="False"} ! methanofuran relationship: has_input_compound UPa:UPC00862 ! methanofuran relationship: has_input_compound UPa:UPC01274 {cardinality="1", is_alternate="False", is_primary="True"} ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC01274 ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01001 {cardinality="1", is_alternate="False", is_primary="True"} ! N-formylmethanofuran relationship: has_output_compound UPa:UPC01001 ! N-formylmethanofuran relationship: has_output_compound UPa:UPC01217 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01217 ! 5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:ULS00345 {cardinality="1", order="4"} ! formate from formaldehyde (H(4)MPT route) relationship: part_of UPa:ULS00345 ! formate from formaldehyde (H(4)MPT route) [Term] id: UPa:UER00705 name: formate from formaldehyde (H(4)MPT route): step 5/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-formylmethanofuran => 1 formate + 1 methanofuran." [] xref: EC:1.2.99.5 xref: GO:0018493 "molecular_function:formylmethanofuran dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC01001 {cardinality="1", is_alternate="False", is_primary="True"} ! N-formylmethanofuran relationship: has_input_compound UPa:UPC01001 ! N-formylmethanofuran relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="True"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00862 ! methanofuran relationship: has_output_compound UPa:UPC00862 {cardinality="1", is_alternate="False", is_primary="False"} ! methanofuran relationship: part_of UPa:ULS00345 {cardinality="1", order="5"} ! formate from formaldehyde (H(4)MPT route) relationship: part_of UPa:ULS00345 ! formate from formaldehyde (H(4)MPT route) [Term] id: UPa:UER00706 name: dinitrogen from nitrate: step 1/4 namespace: enzymatic_reaction def: "1 nitrate + 1 reduced acceptor => 1 H(2)O + 1 acceptor + 1 nitrite." [] xref: EC:1.7.99.4 xref: GO:0008940 "molecular_function:nitrate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_input_compound UPa:UPC00030 ! reduced acceptor relationship: has_input_compound UPa:UPC00244 {cardinality="1", is_alternate="False", is_primary="True"} ! nitrate relationship: has_input_compound UPa:UPC00244 ! nitrate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_output_compound UPa:UPC00028 ! acceptor relationship: has_output_compound UPa:UPC00088 {cardinality="1", is_alternate="False", is_primary="True"} ! nitrite relationship: has_output_compound UPa:UPC00088 ! nitrite relationship: part_of UPa:ULS00347 {cardinality="1", order="1"} ! dinitrogen from nitrate relationship: part_of UPa:ULS00347 ! dinitrogen from nitrate [Term] id: UPa:UER00707 name: dinitrogen from nitrate: step 2/4 namespace: enzymatic_reaction def: "1 H(+) + 1 ferrocytochrome c + 1 nitrite => 1 H(2)O + 1 ferricytochrome c + 1 nitric oxide." [] xref: EC:1.7.2.1 xref: GO:0050421 "molecular_function:nitrite reductase (NO-forming) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00088 ! nitrite relationship: has_input_compound UPa:UPC00088 {cardinality="1", is_alternate="False", is_primary="True"} ! nitrite relationship: has_input_compound UPa:UPC00126 {cardinality="1", is_alternate="False", is_primary="False"} ! ferrocytochrome c relationship: has_input_compound UPa:UPC00126 ! ferrocytochrome c relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00125 ! ferricytochrome c relationship: has_output_compound UPa:UPC00125 {cardinality="1", is_alternate="False", is_primary="False"} ! ferricytochrome c relationship: has_output_compound UPa:UPC00533 {cardinality="1", is_alternate="False", is_primary="True"} ! nitric oxide relationship: has_output_compound UPa:UPC00533 ! nitric oxide relationship: part_of UPa:ULS00347 ! dinitrogen from nitrate relationship: part_of UPa:ULS00347 {cardinality="1", order="2"} ! dinitrogen from nitrate [Term] id: UPa:UER00708 name: dinitrogen from nitrate: step 3/4 namespace: enzymatic_reaction def: "2 H(+) + 2 ferrocytochrome c + 2 nitric oxide => 1 H(2)O + 2 ferricytochrome c + 1 nitrous oxide." [] xref: EC:1.7.2.5 xref: GO:0016966 "molecular_function:nitric oxide reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00126 {cardinality="1", is_alternate="False", is_primary="False"} ! ferrocytochrome c relationship: has_input_compound UPa:UPC00126 ! ferrocytochrome c relationship: has_input_compound UPa:UPC00533 {cardinality="1", is_alternate="False", is_primary="True"} ! nitric oxide relationship: has_input_compound UPa:UPC00533 ! nitric oxide relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00125 ! ferricytochrome c relationship: has_output_compound UPa:UPC00125 {cardinality="1", is_alternate="False", is_primary="False"} ! ferricytochrome c relationship: has_output_compound UPa:UPC00887 ! nitrous oxide relationship: has_output_compound UPa:UPC00887 {cardinality="1", is_alternate="False", is_primary="True"} ! nitrous oxide relationship: part_of UPa:ULS00347 {cardinality="1", order="3"} ! dinitrogen from nitrate relationship: part_of UPa:ULS00347 ! dinitrogen from nitrate [Term] id: UPa:UER00709 name: dinitrogen from nitrate: step 4/4 namespace: enzymatic_reaction def: "2 H(+) + 2 ferrocytochrome c + 1 nitrous oxide => 1 H(2)O + 1 dinitrogen + 2 ferricytochrome c." [] xref: EC:1.7.2.4 xref: GO:0050304 "molecular_function:nitrous-oxide reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00126 {cardinality="1", is_alternate="False", is_primary="False"} ! ferrocytochrome c relationship: has_input_compound UPa:UPC00126 ! ferrocytochrome c relationship: has_input_compound UPa:UPC00887 ! nitrous oxide relationship: has_input_compound UPa:UPC00887 {cardinality="1", is_alternate="False", is_primary="True"} ! nitrous oxide relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00125 ! ferricytochrome c relationship: has_output_compound UPa:UPC00125 {cardinality="1", is_alternate="False", is_primary="False"} ! ferricytochrome c relationship: has_output_compound UPa:UPC00697 {cardinality="1", is_alternate="False", is_primary="True"} ! dinitrogen relationship: has_output_compound UPa:UPC00697 ! dinitrogen relationship: part_of UPa:ULS00347 {cardinality="1", order="4"} ! dinitrogen from nitrate relationship: part_of UPa:ULS00347 ! dinitrogen from nitrate [Term] id: UPa:UER00710 name: acetyl-CoA from malonyl-CoA: step 1/1 namespace: enzymatic_reaction def: "1 malonyl-CoA => 1 CO(2) + 1 acetyl-CoA." [] xref: EC:4.1.1.9 xref: GO:0050080 "molecular_function:malonyl-CoA decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00083 {cardinality="1", is_alternate="False", is_primary="True"} ! malonyl-CoA relationship: has_input_compound UPa:UPC00083 ! malonyl-CoA relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl-CoA relationship: part_of UPa:ULS00348 ! acetyl-CoA from malonyl-CoA relationship: part_of UPa:ULS00348 {cardinality="1", order="1"} ! acetyl-CoA from malonyl-CoA [Term] id: UPa:UER00711 name: malonyl-CoA from acetyl-CoA: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 acetyl-CoA + 1 bicarbonate => 1 ADP + 1 malonyl-CoA + 1 phosphate." [] xref: EC:6.4.1.2 xref: GO:0003989 "molecular_function:acetyl-CoA carboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_input_compound UPa:UPC00288 {cardinality="1", is_alternate="False", is_primary="False"} ! bicarbonate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00083 ! malonyl-CoA relationship: has_output_compound UPa:UPC00083 {cardinality="1", is_alternate="False", is_primary="True"} ! malonyl-CoA relationship: part_of UPa:ULS00349 ! malonyl-CoA from acetyl-CoA relationship: part_of UPa:ULS00349 {cardinality="1", order="1"} ! malonyl-CoA from acetyl-CoA [Term] id: UPa:UER00712 name: heme O from protoheme: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 farnesyl diphosphate + 1 protoheme => 1 diphosphate + 1 heme O." [] xref: EC:2.5.1 xref: GO:0004659 "molecular_function:prenyltransferase activity" xref: GO:0004661 "molecular_function:protein geranylgeranyltransferase activity" xref: GO:0008318 "molecular_function:protein prenyltransferase activity" xref: GO:0008412 "molecular_function:4-hydroxybenzoate octaprenyltransferase activity" xref: GO:0008495 "molecular_function:protoheme IX farnesyltransferase activity" xref: GO:0016765 "molecular_function:transferase activity, transferring alkyl or aryl (other than methyl) groups" xref: GO:0043888 "molecular_function:(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity" xref: GO:0043918 "molecular_function:cadaverine aminopropyltransferase activity" xref: GO:0043919 "molecular_function:agmatine aminopropyltransferase activity" xref: GO:0046428 "molecular_function:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity" xref: GO:0048045 "molecular_function:trans-pentaprenyltranstransferase activity" xref: GO:0052622 "molecular_function:ATP dimethylallyltransferase activity" xref: GO:0052623 "molecular_function:ADP dimethylallyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00032 {cardinality="1", is_alternate="False", is_primary="True"} ! protoheme relationship: has_input_compound UPa:UPC00032 ! protoheme relationship: has_input_compound UPa:UPC00448 {cardinality="1", is_alternate="False", is_primary="False"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC15672 ! heme O relationship: has_output_compound UPa:UPC15672 {cardinality="1", is_alternate="False", is_primary="True"} ! heme O relationship: part_of UPa:ULS00393 ! heme O from protoheme relationship: part_of UPa:ULS00393 {cardinality="1", order="1"} ! heme O from protoheme [Term] id: UPa:UER00713 name: heme A from heme O: step 1/1 namespace: enzymatic_reaction def: "1 heme O => 1 heme A." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC15672 ! heme O relationship: has_input_compound UPa:UPC15672 {cardinality="1", is_alternate="False", is_primary="True"} ! heme O relationship: has_output_compound UPa:UPC15670 ! heme A relationship: has_output_compound UPa:UPC15670 {cardinality="1", is_alternate="False", is_primary="True"} ! heme A relationship: part_of UPa:ULS00350 ! heme A from heme O relationship: part_of UPa:ULS00350 {cardinality="1", order="1"} ! heme A from heme O [Term] id: UPa:UER00714 name: D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 D-galactose 6-phosphate => 1 D-tagatose 6-phosphate." [] xref: EC:5.3.1.26 xref: GO:0050044 "molecular_function:galactose-6-phosphate isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01113 {cardinality="1", is_alternate="False", is_primary="True"} ! D-galactose 6-phosphate relationship: has_input_compound UPa:UPC01113 ! D-galactose 6-phosphate relationship: has_output_compound UPa:UPC01097 ! D-tagatose 6-phosphate relationship: has_output_compound UPa:UPC01097 {cardinality="1", is_alternate="False", is_primary="True"} ! D-tagatose 6-phosphate relationship: part_of UPa:ULS00351 ! D-tagatose 6-phosphate from D-galactose 6-phosphate relationship: part_of UPa:ULS00351 {cardinality="1", order="1"} ! D-tagatose 6-phosphate from D-galactose 6-phosphate [Term] id: UPa:UER00715 name: D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 D-tagatose 6-phosphate => 1 ADP + 1 D-tagatose 1,6-bisphosphate." [] xref: EC:2.7.1.144 xref: GO:0009024 "molecular_function:tagatose-6-phosphate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC01097 ! D-tagatose 6-phosphate relationship: has_input_compound UPa:UPC01097 {cardinality="1", is_alternate="False", is_primary="True"} ! D-tagatose 6-phosphate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC03785 {cardinality="1", is_alternate="False", is_primary="True"} ! D-tagatose 1,6-bisphosphate relationship: has_output_compound UPa:UPC03785 ! D-tagatose 1,6-bisphosphate relationship: part_of UPa:ULS00355 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate relationship: part_of UPa:ULS00355 {cardinality="1", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate [Term] id: UPa:UER00716 name: D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2 namespace: enzymatic_reaction def: "1 D-tagatose 1,6-bisphosphate => 1 D-glyceraldehyde 3-phosphate + 1 glycerone phosphate." [] xref: EC:4.1.2.40 xref: GO:0009025 "molecular_function:tagatose-bisphosphate aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03785 ! D-tagatose 1,6-bisphosphate relationship: has_input_compound UPa:UPC03785 {cardinality="1", is_alternate="False", is_primary="True"} ! D-tagatose 1,6-bisphosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00355 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate relationship: part_of UPa:ULS00355 {cardinality="1", order="2"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate [Term] id: UPa:UER00717 name: isocitrate from oxaloacetate: step 1/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 acetyl-CoA + 1 oxaloacetate => 1 CoA + 1 citrate." [] xref: EC:2.3.3.1 xref: GO:0004108 "molecular_function:citrate (Si)-synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00036 ! oxaloacetate relationship: has_input_compound UPa:UPC00036 {cardinality="1", is_alternate="False", is_primary="True"} ! oxaloacetate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00158 {cardinality="1", is_alternate="False", is_primary="True"} ! citrate relationship: has_output_compound UPa:UPC00158 ! citrate relationship: part_of UPa:ULS00352 ! isocitrate from oxaloacetate relationship: part_of UPa:ULS00352 {cardinality="1", order="1"} ! isocitrate from oxaloacetate [Term] id: UPa:UER00718 name: isocitrate from oxaloacetate: step 2/2 namespace: enzymatic_reaction def: "1 citrate => 1 isocitrate." [] xref: EC:4.2.1.3 xref: GO:0003994 "molecular_function:aconitate hydratase activity" xref: GO:0047780 "molecular_function:citrate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00158 ! citrate relationship: has_input_compound UPa:UPC00158 {cardinality="1", is_alternate="False", is_primary="True"} ! citrate relationship: has_output_compound UPa:UPC00311 {cardinality="1", is_alternate="False", is_primary="True"} ! isocitrate relationship: has_output_compound UPa:UPC00311 ! isocitrate relationship: part_of UPa:ULS00352 ! isocitrate from oxaloacetate relationship: part_of UPa:ULS00352 {cardinality="1", order="2"} ! isocitrate from oxaloacetate [Term] id: UPa:UER00719 name: (S)-malate from isocitrate: step 1/2 namespace: enzymatic_reaction def: "1 isocitrate => 1 glyoxylate + 1 succinate." [] xref: EC:4.1.3.1 xref: GO:0004451 "molecular_function:isocitrate lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00311 {cardinality="1", is_alternate="False", is_primary="True"} ! isocitrate relationship: has_input_compound UPa:UPC00311 ! isocitrate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC00048 ! glyoxylate relationship: has_output_compound UPa:UPC00048 {cardinality="1", is_alternate="False", is_primary="True"} ! glyoxylate relationship: part_of UPa:ULS00353 ! (S)-malate from isocitrate relationship: part_of UPa:ULS00353 {cardinality="1", order="1"} ! (S)-malate from isocitrate [Term] id: UPa:UER00720 name: (S)-malate from isocitrate: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 acetyl-CoA + 1 glyoxylate => 1 (S)-malate + 1 CoA." [] xref: EC:2.3.3.9 xref: GO:0004474 "molecular_function:malate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00048 {cardinality="1", is_alternate="False", is_primary="True"} ! glyoxylate relationship: has_input_compound UPa:UPC00048 ! glyoxylate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00149 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-malate relationship: has_output_compound UPa:UPC00149 ! (S)-malate relationship: part_of UPa:ULS00353 {cardinality="1", order="2"} ! (S)-malate from isocitrate relationship: part_of UPa:ULS00353 ! (S)-malate from isocitrate [Term] id: UPa:UER00721 name: oxaloacetate from (S)-malate: step 1/1 namespace: enzymatic_reaction def: "1 (S)-malate + 1 NAD(+) => 1 H(+) + 1 NADH + 1 oxaloacetate." [] xref: EC:1.1.1.37 xref: GO:0030060 "molecular_function:L-malate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00149 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-malate relationship: has_input_compound UPa:UPC00149 ! (S)-malate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00036 {cardinality="1", is_alternate="False", is_primary="True"} ! oxaloacetate relationship: has_output_compound UPa:UPC00036 ! oxaloacetate relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:ULS00354 {cardinality="1", order="1"} ! oxaloacetate from (S)-malate relationship: part_of UPa:ULS00354 ! oxaloacetate from (S)-malate [Term] id: UPa:UER00722 name: phenylacetate from L-phenylalanine: step 1/3 namespace: enzymatic_reaction def: "1 L-phenylalanine => 1 2-phenylethylamine + 1 CO(2)." [] xref: EC:4.1.1.53 xref: GO:0050174 "molecular_function:phenylalanine decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00079 {cardinality="1", is_alternate="False", is_primary="True"} ! L-phenylalanine relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC05332 ! 2-phenylethylamine relationship: has_output_compound UPa:UPC05332 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-phenylethylamine relationship: part_of UPa:ULS00356 {cardinality="1", order="1"} ! phenylacetate from L-phenylalanine relationship: part_of UPa:ULS00356 ! phenylacetate from L-phenylalanine [Term] id: UPa:UER00723 name: phenylacetate from L-phenylalanine: step 2/3 namespace: enzymatic_reaction def: "1 2-phenylethylamine + 1 H(2)O + 1 O(2) => 1 H(2)O(2) + 1 NH(3) + 1 phenylacetaldehyde." [] xref: EC:1.4.3.21 xref: GO:0008131 "molecular_function:primary amine oxidase activity" xref: GO:0052593 "molecular_function:tryptamine:oxygen oxidoreductase (deaminating) activity" xref: GO:0052594 "molecular_function:aminoacetone:oxygen oxidoreductase(deaminating) activity" xref: GO:0052595 "molecular_function:aliphatic-amine oxidase activity" xref: GO:0052596 "molecular_function:phenethylamine:oxygen oxidoreductase (deaminating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC05332 ! 2-phenylethylamine relationship: has_input_compound UPa:UPC05332 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-phenylethylamine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00601 ! phenylacetaldehyde relationship: has_output_compound UPa:UPC00601 {cardinality="1", is_alternate="False", is_primary="True"} ! phenylacetaldehyde relationship: part_of UPa:ULS00356 {cardinality="1", order="2"} ! phenylacetate from L-phenylalanine relationship: part_of UPa:ULS00356 ! phenylacetate from L-phenylalanine [Term] id: UPa:UER00724 name: phenylacetate from L-phenylalanine: step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 phenylacetaldehyde => 1 H(+) + 1 NADH + 1 phenylacetate." [] xref: EC:1.2.1.39 xref: GO:0008957 "molecular_function:phenylacetaldehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00601 ! phenylacetaldehyde relationship: has_input_compound UPa:UPC00601 {cardinality="1", is_alternate="False", is_primary="True"} ! phenylacetaldehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC07086 ! phenylacetate relationship: has_output_compound UPa:UPC07086 {cardinality="1", is_alternate="False", is_primary="True"} ! phenylacetate relationship: part_of UPa:ULS00356 {cardinality="1", order="3"} ! phenylacetate from L-phenylalanine relationship: part_of UPa:ULS00356 ! phenylacetate from L-phenylalanine [Term] id: UPa:UER00725 name: trans-cinnamate from L-phenylalanine: step 1/1 namespace: enzymatic_reaction def: "1 L-phenylalanine => 1 NH(3) + 1 trans-cinnamate." [] xref: EC:4.3.1.24 xref: GO:0045548 "molecular_function:phenylalanine ammonia-lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine relationship: has_input_compound UPa:UPC00079 {cardinality="1", is_alternate="False", is_primary="True"} ! L-phenylalanine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00423 ! trans-cinnamate relationship: has_output_compound UPa:UPC00423 {cardinality="1", is_alternate="False", is_primary="True"} ! trans-cinnamate relationship: part_of UPa:ULS00357 {cardinality="1", order="1"} ! trans-cinnamate from L-phenylalanine relationship: part_of UPa:ULS00357 ! trans-cinnamate from L-phenylalanine [Term] id: UPa:UER00726 name: kynurenate from L-kynurenine: step 1/2 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 L-kynurenine => 1 4-(2-aminophenyl)-2,4-dioxobutanoate + 1 L-glutamate." [] xref: EC:2.6.1.7 xref: GO:0016212 "molecular_function:kynurenine-oxoglutarate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00328 {cardinality="1", is_alternate="False", is_primary="True"} ! L-kynurenine relationship: has_input_compound UPa:UPC00328 ! L-kynurenine relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC01252 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-(2-aminophenyl)-2,4-dioxobutanoate relationship: has_output_compound UPa:UPC01252 ! 4-(2-aminophenyl)-2,4-dioxobutanoate relationship: part_of UPa:ULS00358 {cardinality="1", order="1"} ! kynurenate from L-kynurenine relationship: part_of UPa:ULS00358 ! kynurenate from L-kynurenine [Term] id: UPa:UER00727 name: kynurenate from L-kynurenine: step 2/2 namespace: enzymatic_reaction def: "1 4-(2-aminophenyl)-2,4-dioxobutanoate => 1 H(2)O + 1 kynurenate." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01252 ! 4-(2-aminophenyl)-2,4-dioxobutanoate relationship: has_input_compound UPa:UPC01252 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-(2-aminophenyl)-2,4-dioxobutanoate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC01717 {cardinality="1", is_alternate="False", is_primary="True"} ! kynurenate relationship: has_output_compound UPa:UPC01717 ! kynurenate relationship: part_of UPa:ULS00358 {cardinality="1", order="2"} ! kynurenate from L-kynurenine relationship: part_of UPa:ULS00358 ! kynurenate from L-kynurenine [Term] id: UPa:UER00728 name: 3,4-dihydroxybenzoate from phthalate: step 1/3 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 phthalate => 1 NAD(+) + 1 cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid." [] xref: EC:1.14.12.7 xref: GO:0018620 "molecular_function:phthalate 4,5-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01606 ! phthalate relationship: has_input_compound UPa:UPC01606 {cardinality="1", is_alternate="False", is_primary="True"} ! phthalate relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC04783 ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid relationship: has_output_compound UPa:UPC04783 {cardinality="1", is_alternate="False", is_primary="True"} ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid relationship: part_of UPa:ULS00359 {cardinality="1", order="1"} ! 3,4-dihydroxybenzoate from phthalate relationship: part_of UPa:ULS00359 ! 3,4-dihydroxybenzoate from phthalate [Term] id: UPa:UER00729 name: 3,4-dihydroxybenzoate from phthalate: step 2/3 namespace: enzymatic_reaction def: "1 NAD(+) + 1 cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid => 1 4,5-dihydroxyphthalate + 1 H(+) + 1 NADH." [] xref: EC:1.3.1.64 xref: GO:0018517 "molecular_function:phthalate 4,5-cis-dihydrodiol dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC04783 ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid relationship: has_input_compound UPa:UPC04783 {cardinality="1", is_alternate="False", is_primary="True"} ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC03233 {cardinality="1", is_alternate="False", is_primary="True"} ! 4,5-dihydroxyphthalate relationship: has_output_compound UPa:UPC03233 ! 4,5-dihydroxyphthalate relationship: part_of UPa:ULS00359 {cardinality="1", order="2"} ! 3,4-dihydroxybenzoate from phthalate relationship: part_of UPa:ULS00359 ! 3,4-dihydroxybenzoate from phthalate [Term] id: UPa:UER00730 name: 3,4-dihydroxybenzoate from phthalate: step 3/3 namespace: enzymatic_reaction def: "1 4,5-dihydroxyphthalate => 1 3,4-dihydroxybenzoate + 1 CO(2)." [] xref: EC:4.1.1.55 xref: GO:0018796 "molecular_function:4,5-dihydroxyphthalate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03233 ! 4,5-dihydroxyphthalate relationship: has_input_compound UPa:UPC03233 {cardinality="1", is_alternate="False", is_primary="True"} ! 4,5-dihydroxyphthalate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00230 {cardinality="1", is_alternate="False", is_primary="True"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: part_of UPa:ULS00359 ! 3,4-dihydroxybenzoate from phthalate relationship: part_of UPa:ULS00359 {cardinality="1", order="3"} ! 3,4-dihydroxybenzoate from phthalate [Term] id: UPa:UER00731 name: 1,3-diaminopropane from L-aspartate 4-semialdehyde: step 1/2 namespace: enzymatic_reaction def: "1 L-aspartate 4-semialdehyde + 1 L-glutamate => 1 2-oxoglutarate + 1 L-2,4-diaminobutanoate." [] xref: EC:2.6.1.76 xref: GO:0045303 "molecular_function:diaminobutyrate-2-oxoglutarate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_input_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC03283 ! L-2,4-diaminobutanoate relationship: has_output_compound UPa:UPC03283 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2,4-diaminobutanoate relationship: part_of UPa:ULS00360 ! 1,3-diaminopropane from L-aspartate 4-semialdehyde relationship: part_of UPa:ULS00360 {cardinality="1", order="1"} ! 1,3-diaminopropane from L-aspartate 4-semialdehyde [Term] id: UPa:UER00732 name: 1,3-diaminopropane from L-aspartate 4-semialdehyde: step 2/2 namespace: enzymatic_reaction def: "1 L-2,4-diaminobutanoate => 1 1,3-diaminopropane + 1 CO(2)." [] xref: EC:4.1.1.86 xref: GO:0033983 "molecular_function:diaminobutyrate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03283 ! L-2,4-diaminobutanoate relationship: has_input_compound UPa:UPC03283 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2,4-diaminobutanoate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00986 ! 1,3-diaminopropane relationship: has_output_compound UPa:UPC00986 {cardinality="1", is_alternate="False", is_primary="True"} ! 1,3-diaminopropane relationship: part_of UPa:ULS00360 ! 1,3-diaminopropane from L-aspartate 4-semialdehyde relationship: part_of UPa:ULS00360 {cardinality="1", order="2"} ! 1,3-diaminopropane from L-aspartate 4-semialdehyde [Term] id: UPa:UER00733 name: dopamine from L-tyrosine: step 1/2 namespace: enzymatic_reaction def: "1 L-tyrosine + 1 O(2) => 1 H(2)O + 1 L-dopa." [] xref: EC:1.14.18.1 xref: GO:0004503 "molecular_function:monophenol monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00082 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tyrosine relationship: has_input_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00355 ! L-dopa relationship: has_output_compound UPa:UPC00355 {cardinality="1", is_alternate="False", is_primary="True"} ! L-dopa relationship: part_of UPa:ULS00361 ! dopamine from L-tyrosine relationship: part_of UPa:ULS00361 {cardinality="1", order="1"} ! dopamine from L-tyrosine [Term] id: UPa:UER00734 name: dopamine from L-tyrosine: step 2/2 namespace: enzymatic_reaction def: "1 L-dopa => 1 CO(2) + 1 dopamine." [] xref: EC:4.1.1.28 xref: GO:0004058 "molecular_function:aromatic-L-amino-acid decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00355 ! L-dopa relationship: has_input_compound UPa:UPC00355 {cardinality="1", is_alternate="False", is_primary="True"} ! L-dopa relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC03758 {cardinality="1", is_alternate="False", is_primary="True"} ! dopamine relationship: has_output_compound UPa:UPC03758 ! dopamine relationship: part_of UPa:ULS00361 ! dopamine from L-tyrosine relationship: part_of UPa:ULS00361 {cardinality="1", order="2"} ! dopamine from L-tyrosine [Term] id: UPa:UER00735 name: (R)-noradrenaline from dopamine: step 1/1 namespace: enzymatic_reaction def: "1 L-ascorbate + 1 O(2) + 1 dopamine => 1 (R)-noradrenaline + 1 H(2)O + 1 L-dehydroascorbate." [] xref: EC:1.14.17.1 xref: GO:0004500 "molecular_function:dopamine beta-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00072 {cardinality="1", is_alternate="False", is_primary="False"} ! L-ascorbate relationship: has_input_compound UPa:UPC00072 ! L-ascorbate relationship: has_input_compound UPa:UPC03758 {cardinality="1", is_alternate="False", is_primary="True"} ! dopamine relationship: has_input_compound UPa:UPC03758 ! dopamine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00547 ! (R)-noradrenaline relationship: has_output_compound UPa:UPC00547 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-noradrenaline relationship: has_output_compound UPa:UPC05422 ! L-dehydroascorbate relationship: has_output_compound UPa:UPC05422 {cardinality="1", is_alternate="False", is_primary="False"} ! L-dehydroascorbate relationship: part_of UPa:ULS00362 ! (R)-noradrenaline from dopamine relationship: part_of UPa:ULS00362 {cardinality="1", order="1"} ! (R)-noradrenaline from dopamine [Term] id: UPa:UER00736 name: (R)-adrenaline from (R)-noradrenaline: step 1/1 namespace: enzymatic_reaction def: "1 (R)-noradrenaline + 1 S-adenosyl-L-methionine => 1 (R)-adrenaline + 1 S-adenosyl-L-homocysteine." [] xref: EC:2.1.1.28 xref: GO:0004603 "molecular_function:phenylethanolamine N-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00547 ! (R)-noradrenaline relationship: has_input_compound UPa:UPC00547 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-noradrenaline relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00788 ! (R)-adrenaline relationship: has_output_compound UPa:UPC00788 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-adrenaline relationship: part_of UPa:ULS00363 ! (R)-adrenaline from (R)-noradrenaline relationship: part_of UPa:ULS00363 {cardinality="1", order="1"} ! (R)-adrenaline from (R)-noradrenaline [Term] id: UPa:UER00737 name: phosphocholine from choline: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 choline => 1 ADP + 1 phosphocholine." [] xref: EC:2.7.1.32 xref: GO:0004103 "molecular_function:choline kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_input_compound UPa:UPC00114 {cardinality="1", is_alternate="False", is_primary="True"} ! choline relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00588 ! phosphocholine relationship: has_output_compound UPa:UPC00588 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphocholine relationship: part_of UPa:ULS00364 ! phosphocholine from choline relationship: part_of UPa:ULS00364 {cardinality="1", order="1"} ! phosphocholine from choline [Term] id: UPa:UER00738 name: phosphocholine from phosphoethanolamine: step 1/1 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 phosphoethanolamine => 1 S-adenosyl-L-homocysteine + 1 phosphocholine." [] xref: EC:2.1.1.103 xref: GO:0000234 "molecular_function:phosphoethanolamine N-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00346 ! phosphoethanolamine relationship: has_input_compound UPa:UPC00346 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphoethanolamine relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00588 ! phosphocholine relationship: has_output_compound UPa:UPC00588 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphocholine relationship: part_of UPa:ULS00365 ! phosphocholine from phosphoethanolamine relationship: part_of UPa:ULS00365 {cardinality="1", order="1"} ! phosphocholine from phosphoethanolamine [Term] id: UPa:UER00739 name: phosphatidylcholine from phosphocholine: step 1/2 namespace: enzymatic_reaction def: "1 CTP + 1 phosphocholine => 1 CDP-choline + 1 diphosphate." [] xref: EC:2.7.7.15 xref: GO:0004105 "molecular_function:choline-phosphate cytidylyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00063 {cardinality="1", is_alternate="False", is_primary="False"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00588 ! phosphocholine relationship: has_input_compound UPa:UPC00588 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphocholine relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00307 ! CDP-choline relationship: has_output_compound UPa:UPC00307 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-choline relationship: part_of UPa:ULS00366 ! phosphatidylcholine from phosphocholine relationship: part_of UPa:ULS00366 {cardinality="1", order="1"} ! phosphatidylcholine from phosphocholine [Term] id: UPa:UER00740 name: phosphatidylcholine from phosphocholine: step 2/2 namespace: enzymatic_reaction def: "1 1,2-diacyl-sn-glycerol + 1 CDP-choline => 1 CMP + 1 phosphatidylcholine." [] xref: EC:2.7.8.2 xref: GO:0004142 "molecular_function:diacylglycerol cholinephosphotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00307 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-choline relationship: has_input_compound UPa:UPC00307 ! CDP-choline relationship: has_input_compound UPa:UPC00641 {cardinality="1", is_alternate="False", is_primary="False"} ! 1,2-diacyl-sn-glycerol relationship: has_input_compound UPa:UPC00641 ! 1,2-diacyl-sn-glycerol relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="False"} ! CMP relationship: has_output_compound UPa:UPC00157 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphatidylcholine relationship: has_output_compound UPa:UPC00157 ! phosphatidylcholine relationship: part_of UPa:ULS00366 {cardinality="1", order="2"} ! phosphatidylcholine from phosphocholine relationship: part_of UPa:ULS00366 ! phosphatidylcholine from phosphocholine [Term] id: UPa:UER00741 name: phosphatidylethanolamine from ethanolamine: step 1/3 namespace: enzymatic_reaction def: "1 ATP + 1 ethanolamine => 1 ADP + 1 phosphoethanolamine." [] xref: EC:2.7.1.82 xref: GO:0004305 "molecular_function:ethanolamine kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00189 {cardinality="1", is_alternate="False", is_primary="True"} ! ethanolamine relationship: has_input_compound UPa:UPC00189 ! ethanolamine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00346 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphoethanolamine relationship: has_output_compound UPa:UPC00346 ! phosphoethanolamine relationship: part_of UPa:ULS00367 {cardinality="1", order="1"} ! phosphatidylethanolamine from ethanolamine relationship: part_of UPa:ULS00367 ! phosphatidylethanolamine from ethanolamine [Term] id: UPa:UER00742 name: phosphatidylethanolamine from ethanolamine: step 2/3 namespace: enzymatic_reaction def: "1 CTP + 1 phosphoethanolamine => 1 CDP-ethanolamine + 1 diphosphate." [] xref: EC:2.7.7.14 xref: GO:0004306 "molecular_function:ethanolamine-phosphate cytidylyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00063 {cardinality="1", is_alternate="False", is_primary="False"} ! CTP relationship: has_input_compound UPa:UPC00346 ! phosphoethanolamine relationship: has_input_compound UPa:UPC00346 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphoethanolamine relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00570 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-ethanolamine relationship: has_output_compound UPa:UPC00570 ! CDP-ethanolamine relationship: part_of UPa:ULS00367 {cardinality="1", order="2"} ! phosphatidylethanolamine from ethanolamine relationship: part_of UPa:ULS00367 ! phosphatidylethanolamine from ethanolamine [Term] id: UPa:UER00743 name: phosphatidylethanolamine from ethanolamine: step 3/3 namespace: enzymatic_reaction def: "1 1,2-diacyl-sn-glycerol + 1 CDP-ethanolamine => 1 CMP + 1 phosphatidylethanolamine." [] xref: EC:2.7.8.1 xref: GO:0004307 "molecular_function:ethanolaminephosphotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00570 ! CDP-ethanolamine relationship: has_input_compound UPa:UPC00570 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-ethanolamine relationship: has_input_compound UPa:UPC00641 {cardinality="1", is_alternate="False", is_primary="False"} ! 1,2-diacyl-sn-glycerol relationship: has_input_compound UPa:UPC00641 ! 1,2-diacyl-sn-glycerol relationship: has_output_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="False"} ! CMP relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00350 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphatidylethanolamine relationship: has_output_compound UPa:UPC00350 ! phosphatidylethanolamine relationship: part_of UPa:ULS00367 {cardinality="1", order="3"} ! phosphatidylethanolamine from ethanolamine relationship: part_of UPa:ULS00367 ! phosphatidylethanolamine from ethanolamine [Term] id: UPa:UER00744 name: dhurrin from L-tyrosine: step 1/3 namespace: enzymatic_reaction def: "2 H(+) + 1 L-tyrosine + 2 NADPH + 2 O(2) => 1 (Z)-(4-hydroxyphenyl)acetaldehyde oxime + 1 CO(2) + 3 H(2)O + 2 NADP(+)." [] xref: EC:1.14.13.41 xref: GO:0050370 "molecular_function:tyrosine N-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00082 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tyrosine relationship: has_input_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC04353 ! (Z)-(4-hydroxyphenyl)acetaldehyde oxime relationship: has_output_compound UPa:UPC04353 {cardinality="1", is_alternate="False", is_primary="True"} ! (Z)-(4-hydroxyphenyl)acetaldehyde oxime relationship: part_of UPa:ULS00368 {cardinality="1", order="1"} ! dhurrin from L-tyrosine relationship: part_of UPa:ULS00368 ! dhurrin from L-tyrosine [Term] id: UPa:UER00745 name: dhurrin from L-tyrosine: step 2/3 namespace: enzymatic_reaction def: "1 (Z)-(4-hydroxyphenyl)acetaldehyde oxime + 1 H(+) + 1 NADPH + 1 O(2) => 1 (S)-4-hydroxymandelonitrile + 2 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.68 xref: GO:0047085 "molecular_function:hydroxyphenylacetonitrile 2-monooxygenase activity" xref: GO:0050592 "molecular_function:4-hydroxyphenylacetaldehyde oxime monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC04353 ! (Z)-(4-hydroxyphenyl)acetaldehyde oxime relationship: has_input_compound UPa:UPC04353 {cardinality="1", is_alternate="False", is_primary="True"} ! (Z)-(4-hydroxyphenyl)acetaldehyde oxime relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC03742 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-4-hydroxymandelonitrile relationship: has_output_compound UPa:UPC03742 ! (S)-4-hydroxymandelonitrile relationship: part_of UPa:ULS00368 {cardinality="1", order="2"} ! dhurrin from L-tyrosine relationship: part_of UPa:ULS00368 ! dhurrin from L-tyrosine [Term] id: UPa:UER00746 name: dhurrin from L-tyrosine: step 3/3 namespace: enzymatic_reaction def: "1 (S)-4-hydroxymandelonitrile + 1 UDP-alpha-D-glucose => 1 UDP + 1 dhurrin." [] xref: EC:2.4.1.85 xref: GO:0047792 "molecular_function:cyanohydrin beta-glucosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00029 ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC00029 {cardinality="1", is_alternate="False", is_primary="False"} ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC03742 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-4-hydroxymandelonitrile relationship: has_input_compound UPa:UPC03742 ! (S)-4-hydroxymandelonitrile relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00015 {cardinality="1", is_alternate="False", is_primary="False"} ! UDP relationship: has_output_compound UPa:UPC05143 {cardinality="1", is_alternate="False", is_primary="True"} ! dhurrin relationship: has_output_compound UPa:UPC05143 ! dhurrin relationship: part_of UPa:ULS00368 {cardinality="1", order="3"} ! dhurrin from L-tyrosine relationship: part_of UPa:ULS00368 ! dhurrin from L-tyrosine [Term] id: UPa:UER00747 name: AMP from 3',5'-cyclic AMP: step 1/1 namespace: enzymatic_reaction def: "1 3',5'-cyclic AMP + 1 H(2)O => 1 AMP." [] xref: EC:3.1.4.17 xref: GO:0004114 "molecular_function:3',5'-cyclic-nucleotide phosphodiesterase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00575 ! 3',5'-cyclic AMP relationship: has_input_compound UPa:UPC00575 {cardinality="1", is_alternate="False", is_primary="True"} ! 3',5'-cyclic AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="True"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: part_of UPa:ULS00369 {cardinality="1", order="1"} ! AMP from 3',5'-cyclic AMP relationship: part_of UPa:ULS00369 ! AMP from 3',5'-cyclic AMP [Term] id: UPa:UER00748 name: GMP from 3',5'-cyclic GMP: step 1/1 namespace: enzymatic_reaction def: "1 3',5'-cyclic GMP + 1 H(2)O => 1 GMP." [] xref: EC:3.1.4.35 xref: GO:0047555 "molecular_function:3',5'-cyclic-GMP phosphodiesterase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00942 ! 3',5'-cyclic GMP relationship: has_input_compound UPa:UPC00942 {cardinality="1", is_alternate="False", is_primary="True"} ! 3',5'-cyclic GMP relationship: has_output_compound UPa:UPC00144 ! GMP relationship: has_output_compound UPa:UPC00144 {cardinality="1", is_alternate="False", is_primary="True"} ! GMP relationship: part_of UPa:ULS00370 {cardinality="1", order="1"} ! GMP from 3',5'-cyclic GMP relationship: part_of UPa:ULS00370 ! GMP from 3',5'-cyclic GMP [Term] id: UPa:UER00749 name: 5-valerolactone from cyclopentanol: step 1/2 namespace: enzymatic_reaction def: "1 NAD(+) + 1 cyclopentanol => 1 H(+) + 1 NADH + 1 cyclopentanone." [] xref: EC:1.1.1.163 xref: GO:0055041 "molecular_function:cyclopentanol dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC02020 {cardinality="1", is_alternate="False", is_primary="True"} ! cyclopentanol relationship: has_input_compound UPa:UPC02020 ! cyclopentanol relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00557 {cardinality="1", is_alternate="False", is_primary="True"} ! cyclopentanone relationship: has_output_compound UPa:UPC00557 ! cyclopentanone relationship: part_of UPa:ULS00371 {cardinality="1", order="1"} ! 5-valerolactone from cyclopentanol relationship: part_of UPa:ULS00371 ! 5-valerolactone from cyclopentanol [Term] id: UPa:UER00750 name: 5-valerolactone from cyclopentanol: step 2/2 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 O(2) + 1 cyclopentanone => 1 5-valerolactone + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.16 xref: GO:0047799 "molecular_function:cyclopentanone monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00557 ! cyclopentanone relationship: has_input_compound UPa:UPC00557 {cardinality="1", is_alternate="False", is_primary="True"} ! cyclopentanone relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC02240 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-valerolactone relationship: has_output_compound UPa:UPC02240 ! 5-valerolactone relationship: part_of UPa:ULS00371 ! 5-valerolactone from cyclopentanol relationship: part_of UPa:ULS00371 {cardinality="1", order="2"} ! 5-valerolactone from cyclopentanol [Term] id: UPa:UER00751 name: lanosterol from farnesyl diphosphate: step 1/3 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 2 farnesyl diphosphate => 1 NADP(+) + 2 diphosphate + 1 squalene." [] xref: EC:2.5.1.21 xref: GO:0004310 "molecular_function:farnesyl-diphosphate farnesyltransferase activity" xref: GO:0051996 "molecular_function:squalene synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00448 {cardinality="1", is_alternate="False", is_primary="True"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00751 ! squalene relationship: has_output_compound UPa:UPC00751 {cardinality="1", is_alternate="False", is_primary="True"} ! squalene relationship: part_of UPa:ULS00372 ! lanosterol from farnesyl diphosphate relationship: part_of UPa:ULS00372 {cardinality="1", order="1"} ! lanosterol from farnesyl diphosphate [Term] id: UPa:UER00752 name: lanosterol from farnesyl diphosphate: step 2/3 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 O(2) + 1 squalene => 1 (S)-2,3-epoxysqualene + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.132 xref: GO:0004506 "molecular_function:squalene monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00751 {cardinality="1", is_alternate="False", is_primary="True"} ! squalene relationship: has_input_compound UPa:UPC00751 ! squalene relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC01054 ! (S)-2,3-epoxysqualene relationship: has_output_compound UPa:UPC01054 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2,3-epoxysqualene relationship: part_of UPa:ULS00372 ! lanosterol from farnesyl diphosphate relationship: part_of UPa:ULS00372 {cardinality="1", order="2"} ! lanosterol from farnesyl diphosphate [Term] id: UPa:UER00753 name: lanosterol from farnesyl diphosphate: step 3/3 namespace: enzymatic_reaction def: "1 (S)-2,3-epoxysqualene => 1 lanosterol." [] xref: EC:5.4.99.7 xref: GO:0000250 "molecular_function:lanosterol synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01054 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2,3-epoxysqualene relationship: has_input_compound UPa:UPC01054 ! (S)-2,3-epoxysqualene relationship: has_output_compound UPa:UPC01724 ! lanosterol relationship: has_output_compound UPa:UPC01724 {cardinality="1", is_alternate="False", is_primary="True"} ! lanosterol relationship: part_of UPa:ULS00372 ! lanosterol from farnesyl diphosphate relationship: part_of UPa:ULS00372 {cardinality="1", order="3"} ! lanosterol from farnesyl diphosphate [Term] id: UPa:UER00754 name: zymosterol from lanosterol: step 1/6 namespace: enzymatic_reaction def: "3 H(+) + 3 NADPH + 3 O(2) + 1 lanosterol => 1 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + 4 H(2)O + 3 NADP(+) + 1 formate." [] xref: EC:1.14.13.70 xref: GO:0008398 "molecular_function:sterol 14-demethylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC01724 ! lanosterol relationship: has_input_compound UPa:UPC01724 {cardinality="1", is_alternate="False", is_primary="True"} ! lanosterol relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_output_compound UPa:UPC11455 {cardinality="1", is_alternate="False", is_primary="True"} ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol relationship: has_output_compound UPa:UPC11455 ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol relationship: part_of UPa:ULS00373 ! zymosterol from lanosterol relationship: part_of UPa:ULS00373 {cardinality="1", order="1"} ! zymosterol from lanosterol [Term] id: UPa:UER00755 name: zymosterol from lanosterol: step 2/6 namespace: enzymatic_reaction def: "1 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + 1 H(+) + 1 NADPH => 1 14-demethyllanosterol + 1 NADP(+)." [] xref: EC:1.3.1.70 xref: GO:0050613 "molecular_function:delta14-sterol reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC11455 {cardinality="1", is_alternate="False", is_primary="True"} ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol relationship: has_input_compound UPa:UPC11455 ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC05108 {cardinality="1", is_alternate="False", is_primary="True"} ! 14-demethyllanosterol relationship: has_output_compound UPa:UPC05108 ! 14-demethyllanosterol relationship: part_of UPa:ULS00373 ! zymosterol from lanosterol relationship: part_of UPa:ULS00373 {cardinality="1", order="2"} ! zymosterol from lanosterol [Term] id: UPa:UER00756 name: zymosterol from lanosterol: step 3/6 namespace: enzymatic_reaction def: "1 14-demethyllanosterol + 3 H(+) + 3 NADPH + 3 O(2) => 1 4alpha-methylzymosterol-4-carboxylic acid + 4 H(2)O + 3 NADP(+)." [] xref: EC:1.14.13.72 xref: GO:0000254 "molecular_function:C-4 methylsterol oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC05108 ! 14-demethyllanosterol relationship: has_input_compound UPa:UPC05108 {cardinality="1", is_alternate="False", is_primary="True"} ! 14-demethyllanosterol relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC15808 {cardinality="1", is_alternate="False", is_primary="True"} ! 4alpha-methylzymosterol-4-carboxylic acid relationship: has_output_compound UPa:UPC15808 ! 4alpha-methylzymosterol-4-carboxylic acid relationship: part_of UPa:ULS00373 ! zymosterol from lanosterol relationship: part_of UPa:ULS00373 {cardinality="1", order="3"} ! zymosterol from lanosterol [Term] id: UPa:UER00757 name: zymosterol from lanosterol: step 4/6 namespace: enzymatic_reaction def: "1 4alpha-methylzymosterol-4-carboxylic acid + 1 NADP(+) => 1 3-dehydro-4-methylzymosterol + 1 CO(2) + 1 H(+) + 1 NADPH." [] xref: EC:1.1.1.170 xref: GO:0047012 "molecular_function:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC15808 ! 4alpha-methylzymosterol-4-carboxylic acid relationship: has_input_compound UPa:UPC15808 {cardinality="1", is_alternate="False", is_primary="True"} ! 4alpha-methylzymosterol-4-carboxylic acid relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC15816 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydro-4-methylzymosterol relationship: has_output_compound UPa:UPC15816 ! 3-dehydro-4-methylzymosterol relationship: part_of UPa:ULS00373 ! zymosterol from lanosterol relationship: part_of UPa:ULS00373 {cardinality="1", order="4"} ! zymosterol from lanosterol [Term] id: UPa:UER00758 name: zymosterol from lanosterol: step 5/6 namespace: enzymatic_reaction def: "1 3-dehydro-4-methylzymosterol + 1 H(+) + 1 NADPH => 1 4-alpha-methylzymosterol + 1 NADP(+)." [] xref: EC:1.1.1.270 xref: GO:0000253 "molecular_function:3-keto sterol reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC15816 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydro-4-methylzymosterol relationship: has_input_compound UPa:UPC15816 ! 3-dehydro-4-methylzymosterol relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC05103 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-alpha-methylzymosterol relationship: has_output_compound UPa:UPC05103 ! 4-alpha-methylzymosterol relationship: part_of UPa:ULS00373 ! zymosterol from lanosterol relationship: part_of UPa:ULS00373 {cardinality="1", order="5"} ! zymosterol from lanosterol [Term] id: UPa:UER00759 name: zymosterol from lanosterol: step 6/6 namespace: enzymatic_reaction def: "1 4-alpha-methylzymosterol => 1 zymosterol." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC05103 ! 4-alpha-methylzymosterol relationship: has_input_compound UPa:UPC05103 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-alpha-methylzymosterol relationship: has_output_compound UPa:UPC05437 ! zymosterol relationship: has_output_compound UPa:UPC05437 {cardinality="1", is_alternate="False", is_primary="True"} ! zymosterol relationship: part_of UPa:ULS00373 ! zymosterol from lanosterol relationship: part_of UPa:ULS00373 {cardinality="1", order="6"} ! zymosterol from lanosterol [Term] id: UPa:UER00760 name: ergosterol from zymosterol: step 1/5 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 zymosterol => 1 S-adenosyl-L-homocysteine + 1 fecosterol." [] xref: EC:2.1.1.41 xref: GO:0003838 "molecular_function:sterol 24-C-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC05437 {cardinality="1", is_alternate="False", is_primary="True"} ! zymosterol relationship: has_input_compound UPa:UPC05437 ! zymosterol relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC04525 {cardinality="1", is_alternate="False", is_primary="True"} ! fecosterol relationship: has_output_compound UPa:UPC04525 ! fecosterol relationship: part_of UPa:ULS00374 {cardinality="1", order="1"} ! ergosterol from zymosterol relationship: part_of UPa:ULS00374 ! ergosterol from zymosterol [Term] id: UPa:UER00761 name: ergosterol from zymosterol: step 2/5 namespace: enzymatic_reaction def: "1 fecosterol => 1 episterol." [] xref: EC:5 xref: GO:0008719 "molecular_function:dihydroneopterin triphosphate 2'-epimerase activity" xref: GO:0009385 "molecular_function:N-acylmannosamine-6-phosphate 2-epimerase activity" xref: GO:0016853 "molecular_function:isomerase activity" xref: GO:0043800 "molecular_function:hexulose-6-phosphate isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04525 {cardinality="1", is_alternate="False", is_primary="True"} ! fecosterol relationship: has_input_compound UPa:UPC04525 ! fecosterol relationship: has_output_compound UPa:UPC15777 {cardinality="1", is_alternate="False", is_primary="True"} ! episterol relationship: has_output_compound UPa:UPC15777 ! episterol relationship: part_of UPa:ULS00374 {cardinality="1", order="2"} ! ergosterol from zymosterol relationship: part_of UPa:ULS00374 ! ergosterol from zymosterol [Term] id: UPa:UER00762 name: ergosterol from zymosterol: step 3/5 namespace: enzymatic_reaction def: "1 NADP(+) + 1 episterol => 1 5,7,24(28)-ergostatrienol + 1 H(+) + 1 NADPH." [] xref: EC:1.14 xref: GO:0016705 "molecular_function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" xref: GO:0018585 "molecular_function:fluorene oxygenase activity" xref: GO:0018586 "molecular_function:mono-butyltin dioxygenase activity" xref: GO:0018588 "molecular_function:tri-n-butyltin dioxygenase activity" xref: GO:0018589 "molecular_function:di-n-butyltin dioxygenase activity" xref: GO:0018590 "molecular_function:methylsilanetriol hydroxylase activity" xref: GO:0018591 "molecular_function:methyl tertiary butyl ether 3-monooxygenase activity" xref: GO:0018592 "molecular_function:4-nitrocatechol 4-monooxygenase activity" xref: GO:0018593 "molecular_function:4-chlorophenoxyacetate monooxygenase activity" xref: GO:0018594 "molecular_function:tert-butanol 2-monooxygenase activity" xref: GO:0018595 "molecular_function:alpha-pinene monooxygenase activity" xref: GO:0018596 "molecular_function:dimethylsilanediol hydroxylase activity" xref: GO:0018597 "molecular_function:ammonia monooxygenase activity" xref: GO:0018598 "molecular_function:hydroxymethylsilanetriol oxidase activity" xref: GO:0018599 "molecular_function:2-hydroxyisobutyrate 3-monooxygenase activity" xref: GO:0018600 "molecular_function:alpha-pinene dehydrogenase activity" xref: GO:0034559 "molecular_function:bisphenol A hydroxylase B activity" xref: GO:0034562 "molecular_function:2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity" xref: GO:0034786 "molecular_function:9-fluorenone-3,4-dioxygenase activity" xref: GO:0034816 "molecular_function:anthracene 9,10-dioxygenase activity" xref: GO:0034857 "molecular_function:2-(methylthio)benzothiazole monooxygenase activity" xref: GO:0034858 "molecular_function:2-hydroxybenzothiazole monooxygenase activity" xref: GO:0034859 "molecular_function:benzothiazole monooxygenase activity" xref: GO:0034862 "molecular_function:2,6-dihydroxybenzothiazole monooxygenase activity" xref: GO:0034870 "molecular_function:pinacolone 5-monooxygenase activity" xref: GO:0034873 "molecular_function:thioacetamide S-oxygenase activity" xref: GO:0034874 "molecular_function:thioacetamide S-oxide S-oxygenase activity" xref: GO:0034888 "molecular_function:endosulfan monooxygenase I activity" xref: GO:0034893 "molecular_function:N-nitrodimethylamine hydroxylase activity" xref: GO:0034897 "molecular_function:4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity" xref: GO:0034903 "molecular_function:endosulfan ether monooxygenase activity" xref: GO:0034925 "molecular_function:pyrene 4,5-monooxygenase activity" xref: GO:0034927 "molecular_function:pyrene 1,2-monooxygenase activity" xref: GO:0034928 "molecular_function:1-hydroxypyrene 6,7-monooxygenase activity" xref: GO:0034929 "molecular_function:1-hydroxypyrene 7,8-monooxygenase activity" xref: GO:0034950 "molecular_function:phenylboronic acid monooxygenase activity" xref: GO:0043823 "molecular_function:spheroidene monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC15777 {cardinality="1", is_alternate="False", is_primary="True"} ! episterol relationship: has_input_compound UPa:UPC15777 ! episterol relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC15778 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,7,24(28)-ergostatrienol relationship: has_output_compound UPa:UPC15778 ! 5,7,24(28)-ergostatrienol relationship: part_of UPa:ULS00374 {cardinality="1", order="3"} ! ergosterol from zymosterol relationship: part_of UPa:ULS00374 ! ergosterol from zymosterol [Term] id: UPa:UER00763 name: ergosterol from zymosterol: step 4/5 namespace: enzymatic_reaction def: "1 5,7,24(28)-ergostatrienol + 1 NADP(+) => 1 H(+) + 1 NADPH + 1 ergosta-5,7,22,24(28)-tetraen-3beta-ol." [] xref: EC:1.14.14 xref: GO:0008681 "molecular_function:2-octaprenyl-6-methoxyphenol hydroxylase activity" xref: GO:0016712 "molecular_function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen" xref: GO:0018679 "molecular_function:dibenzothiophene-5,5-dioxide monooxygenase activity" xref: GO:0034938 "molecular_function:pyrrole-2-carboxylate monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC15778 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,7,24(28)-ergostatrienol relationship: has_input_compound UPa:UPC15778 ! 5,7,24(28)-ergostatrienol relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC05440 {cardinality="1", is_alternate="False", is_primary="True"} ! ergosta-5,7,22,24(28)-tetraen-3beta-ol relationship: has_output_compound UPa:UPC05440 ! ergosta-5,7,22,24(28)-tetraen-3beta-ol relationship: part_of UPa:ULS00374 {cardinality="1", order="4"} ! ergosterol from zymosterol relationship: part_of UPa:ULS00374 ! ergosterol from zymosterol [Term] id: UPa:UER00764 name: ergosterol from zymosterol: step 5/5 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 ergosta-5,7,22,24(28)-tetraen-3beta-ol => 1 NADP(+) + 1 ergosterol." [] xref: EC:1.3.1.71 xref: GO:0000246 "molecular_function:delta24(24-1) sterol reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC05440 ! ergosta-5,7,22,24(28)-tetraen-3beta-ol relationship: has_input_compound UPa:UPC05440 {cardinality="1", is_alternate="False", is_primary="True"} ! ergosta-5,7,22,24(28)-tetraen-3beta-ol relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC01694 ! ergosterol relationship: has_output_compound UPa:UPC01694 {cardinality="1", is_alternate="False", is_primary="True"} ! ergosterol relationship: part_of UPa:ULS00374 {cardinality="1", order="5"} ! ergosterol from zymosterol relationship: part_of UPa:ULS00374 ! ergosterol from zymosterol [Term] id: UPa:UER00765 name: dehydro-D-arabinono-1,4-lactone from D-arabinose: step 1/2 namespace: enzymatic_reaction def: "D-arabinose + [NAD(+) or NADP(+)] => D-arabinono-1,4-lactone + H(+) + [NADH or NADPH]." [] xref: EC:1.1.1.116 xref: EC:1.1.1.117 xref: GO:0045290 "molecular_function:D-arabinose 1-dehydrogenase [NAD(P)+] activity" xref: GO:0047816 "molecular_function:D-arabinose 1-dehydrogenase (NAD) activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00977 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00978 ! None relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00216 ! D-arabinose relationship: has_input_compound UPa:UPC00216 {cardinality="1", is_alternate="False", is_primary="True"} ! D-arabinose relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00652 ! D-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC00652 {cardinality="1", is_alternate="False", is_primary="True"} ! D-arabinono-1,4-lactone relationship: part_of UPa:ULS00375 {cardinality="1", order="1"} ! dehydro-D-arabinono-1,4-lactone from D-arabinose relationship: part_of UPa:ULS00375 ! dehydro-D-arabinono-1,4-lactone from D-arabinose [Term] id: UPa:UER00766 name: dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2 namespace: enzymatic_reaction def: "1 D-arabinono-1,4-lactone + 1 O(2) => 1 H(2)O(2) + 1 dehydro-D-arabinono-1,4-lactone." [] xref: EC:1.1.3.37 xref: GO:0003885 "molecular_function:D-arabinono-1,4-lactone oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00652 ! D-arabinono-1,4-lactone relationship: has_input_compound UPa:UPC00652 {cardinality="1", is_alternate="False", is_primary="True"} ! D-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC06316 ! dehydro-D-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC06316 {cardinality="1", is_alternate="False", is_primary="True"} ! dehydro-D-arabinono-1,4-lactone relationship: part_of UPa:ULS00375 {cardinality="1", order="2"} ! dehydro-D-arabinono-1,4-lactone from D-arabinose relationship: part_of UPa:ULS00375 ! dehydro-D-arabinono-1,4-lactone from D-arabinose [Term] id: UPa:UER00767 name: acetate from ethanol: step 1/2 namespace: enzymatic_reaction def: "1 NAD(+) + 1 ethanol => 1 H(+) + 1 NADH + 1 acetaldehyde." [] xref: EC:1.1.1.1 xref: GO:0004022 "molecular_function:alcohol dehydrogenase (NAD) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00469 ! ethanol relationship: has_input_compound UPa:UPC00469 {cardinality="1", is_alternate="False", is_primary="True"} ! ethanol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00084 {cardinality="1", is_alternate="False", is_primary="True"} ! acetaldehyde relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: part_of UPa:ULS00376 {cardinality="1", order="1"} ! acetate from ethanol relationship: part_of UPa:ULS00376 ! acetate from ethanol [Term] id: UPa:UER00768 name: acetate from ethanol: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 acetaldehyde => 1 H(+) + 1 NADH + 1 acetate." [] xref: EC:1.2.1.3 xref: GO:0004029 "molecular_function:aldehyde dehydrogenase (NAD) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00084 {cardinality="1", is_alternate="False", is_primary="True"} ! acetaldehyde relationship: has_input_compound UPa:UPC00084 ! acetaldehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="True"} ! acetate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:ULS00376 {cardinality="1", order="2"} ! acetate from ethanol relationship: part_of UPa:ULS00376 ! acetate from ethanol [Term] id: UPa:UER00769 name: D-glucose 6-phosphate and lysine from fructoselysine: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 fructoselysine => 1 ADP + 1 fructoselysine 6-phosphate." [] xref: EC:2.7.1 xref: GO:0008443 "molecular_function:phosphofructokinase activity" xref: GO:0008607 "molecular_function:phosphorylase kinase regulator activity" xref: GO:0008819 "molecular_function:cobinamide kinase activity" xref: GO:0010276 "molecular_function:phytol kinase activity" xref: GO:0016307 "molecular_function:phosphatidylinositol phosphate kinase activity" xref: GO:0016538 "molecular_function:cyclin-dependent protein serine/threonine kinase regulator activity" xref: GO:0016773 "molecular_function:phosphotransferase activity, alcohol group as acceptor" xref: GO:0018720 "molecular_function:phenol kinase activity" xref: GO:0019914 "molecular_function:cyclin-dependent protein kinase activating kinase regulator activity" xref: GO:0032942 "molecular_function:inositol tetrakisphosphate 2-kinase activity" xref: GO:0033785 "molecular_function:heptose 7-phosphate kinase activity" xref: GO:0034071 "molecular_function:aminoglycoside phosphotransferase activity" xref: GO:0035004 "molecular_function:phosphatidylinositol 3-kinase activity" xref: GO:0042556 "molecular_function:eukaryotic elongation factor-2 kinase regulator activity" xref: GO:0042557 "molecular_function:eukaryotic elongation factor-2 kinase activator activity" xref: GO:0043743 "molecular_function:LPPG:FO 2-phospho-L-lactate transferase activity" xref: GO:0043771 "molecular_function:cytidine kinase activity" xref: GO:0043798 "molecular_function:glycerate 2-kinase activity" xref: GO:0043841 "molecular_function:(S)-lactate 2-kinase activity" xref: GO:0043899 "molecular_function:phosphoserine:homoserine phosphotransferase activity" xref: GO:0043915 "molecular_function:L-seryl-tRNA(Sec) kinase activity" xref: GO:0044605 "molecular_function:phosphocholine transferase activity" xref: GO:0051731 "molecular_function:polynucleotide 5'-hydroxyl-kinase activity" xref: GO:0051734 "molecular_function:ATP-dependent polynucleotide kinase activity" xref: GO:0051735 "molecular_function:GTP-dependent polynucleotide kinase activity" xref: GO:0052668 "molecular_function:farnesol kinase activity" xref: GO:0052669 "molecular_function:CTP:2-trans,-6-trans-farnesol kinase activity" xref: GO:0052670 "molecular_function:geraniol kinase activity" xref: GO:0052671 "molecular_function:geranylgeraniol kinase activity" xref: GO:0052672 "molecular_function:CTP:geranylgeraniol kinase activity" xref: GO:0052673 "molecular_function:prenol kinase activity" xref: GO:0052810 "molecular_function:1-phosphatidylinositol-5-kinase activity" xref: GO:0052811 "molecular_function:1-phosphatidylinositol-3-phosphate 4-kinase activity" xref: GO:0052812 "molecular_function:phosphatidylinositol-3,4-bisphosphate 5-kinase activity" xref: GO:0052813 "molecular_function:phosphatidylinositol bisphosphate kinase activity" xref: GO:0052835 "molecular_function:inositol-3,4,6-trisphosphate 1-kinase activity" xref: GO:0052836 "molecular_function:inositol 5-diphosphate pentakisphosphate 5-kinase activity" xref: GO:0052839 "molecular_function:inositol diphosphate tetrakisphosphate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC16488 ! fructoselysine relationship: has_input_compound UPa:UPC16488 {cardinality="1", is_alternate="False", is_primary="True"} ! fructoselysine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC16489 {cardinality="1", is_alternate="False", is_primary="True"} ! fructoselysine 6-phosphate relationship: has_output_compound UPa:UPC16489 ! fructoselysine 6-phosphate relationship: part_of UPa:ULS00377 {cardinality="1", order="1"} ! D-glucose 6-phosphate and lysine from fructoselysine relationship: part_of UPa:ULS00377 ! D-glucose 6-phosphate and lysine from fructoselysine [Term] id: UPa:UER00770 name: D-glucose 6-phosphate and lysine from fructoselysine: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 fructoselysine 6-phosphate => 1 D-glucose 6-phosphate + 1 L-lysine." [] xref: EC:3.5 xref: GO:0016810 "molecular_function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC16489 {cardinality="1", is_alternate="False", is_primary="True"} ! fructoselysine 6-phosphate relationship: has_input_compound UPa:UPC16489 ! fructoselysine 6-phosphate relationship: has_output_compound UPa:UPC00047 {cardinality="1", is_alternate="False", is_primary="False"} ! L-lysine relationship: has_output_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC00092 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: part_of UPa:ULS00377 {cardinality="1", order="2"} ! D-glucose 6-phosphate and lysine from fructoselysine relationship: part_of UPa:ULS00377 ! D-glucose 6-phosphate and lysine from fructoselysine [Term] id: UPa:UER00771 name: UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1 namespace: enzymatic_reaction def: "1 UDP-alpha-D-glucuronate => 1 CO(2) + 1 UDP-alpha-D-xylose." [] xref: EC:4.1.1.35 xref: GO:0048040 "molecular_function:UDP-glucuronate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate relationship: has_input_compound UPa:UPC00167 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00190 ! UDP-alpha-D-xylose relationship: has_output_compound UPa:UPC00190 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-alpha-D-xylose relationship: part_of UPa:ULS00378 ! UDP-alpha-D-xylose from UDP-alpha-D-glucuronate relationship: part_of UPa:ULS00378 {cardinality="1", order="1"} ! UDP-alpha-D-xylose from UDP-alpha-D-glucuronate [Term] id: UPa:UER00772 name: UDP-L-arabinose from UDP-alpha-D-xylose: step 1/1 namespace: enzymatic_reaction def: "1 UDP-alpha-D-xylose => 1 UDP-L-arabinose." [] xref: EC:5.1.3.5 xref: GO:0050373 "molecular_function:UDP-arabinose 4-epimerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00190 ! UDP-alpha-D-xylose relationship: has_input_compound UPa:UPC00190 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-alpha-D-xylose relationship: has_output_compound UPa:UPC00935 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-L-arabinose relationship: has_output_compound UPa:UPC00935 ! UDP-L-arabinose relationship: part_of UPa:ULS00379 ! UDP-L-arabinose from UDP-alpha-D-xylose relationship: part_of UPa:ULS00379 {cardinality="1", order="1"} ! UDP-L-arabinose from UDP-alpha-D-xylose [Term] id: UPa:UER00773 name: all-trans-phytoene from geranylgeranyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "2 geranylgeranyl diphosphate => 1 all-trans-phytoene + 2 diphosphate." [] xref: EC:2.5.1.99 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00353 {cardinality="1", is_alternate="False", is_primary="True"} ! geranylgeranyl diphosphate relationship: has_input_compound UPa:UPC00353 ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC05413 ! all-trans-phytoene relationship: has_output_compound UPa:UPC05413 {cardinality="1", is_alternate="False", is_primary="True"} ! all-trans-phytoene relationship: part_of UPa:ULS00380 ! all-trans-phytoene from geranylgeranyl diphosphate relationship: part_of UPa:ULS00380 {cardinality="1", order="1"} ! all-trans-phytoene from geranylgeranyl diphosphate [Term] id: UPa:UER00774 name: capsanthin from antheraxanthin: step 1/1 namespace: enzymatic_reaction def: "1 antheraxanthin => 1 capsanthin." [] xref: EC:5.3.99.8 xref: GO:0052727 "molecular_function:capsanthin synthase activity" xref: GO:0052728 "molecular_function:capsorubin synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC08579 {cardinality="1", is_alternate="False", is_primary="True"} ! antheraxanthin relationship: has_input_compound UPa:UPC08579 ! antheraxanthin relationship: has_output_compound UPa:UPC08584 {cardinality="1", is_alternate="False", is_primary="True"} ! capsanthin relationship: has_output_compound UPa:UPC08584 ! capsanthin relationship: part_of UPa:ULS00381 ! capsanthin from antheraxanthin relationship: part_of UPa:ULS00381 {cardinality="1", order="1"} ! capsanthin from antheraxanthin [Term] id: UPa:UER00775 name: capsorubin from violaxanthin: step 1/1 namespace: enzymatic_reaction def: "1 violaxanthin => 1 capsorubin." [] xref: EC:5.3.99.8 xref: GO:0052727 "molecular_function:capsanthin synthase activity" xref: GO:0052728 "molecular_function:capsorubin synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC08614 ! violaxanthin relationship: has_input_compound UPa:UPC08614 {cardinality="1", is_alternate="False", is_primary="True"} ! violaxanthin relationship: has_output_compound UPa:UPC08585 {cardinality="1", is_alternate="False", is_primary="True"} ! capsorubin relationship: has_output_compound UPa:UPC08585 ! capsorubin relationship: part_of UPa:ULS00382 ! capsorubin from violaxanthin relationship: part_of UPa:ULS00382 {cardinality="1", order="1"} ! capsorubin from violaxanthin [Term] id: UPa:UER00776 name: 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 1/3 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 dibenzofuran => 1 NAD(+) + 1 biphenyl-2,2',3-triol." [] xref: EC:1.14.12 xref: GO:0016708 "molecular_function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor" xref: GO:0018603 "molecular_function:nitrobenzene 1,2-dioxygenase activity" xref: GO:0018604 "molecular_function:4-aminobenzoate 3,4-dioxygenase (deaminating) activity" xref: GO:0018606 "molecular_function:benzenesulfonate dioxygenase activity" xref: GO:0018607 "molecular_function:1-indanone monooxygenase activity" xref: GO:0018608 "molecular_function:1-indanone dioxygenase activity" xref: GO:0018609 "molecular_function:chlorobenzene dioxygenase activity" xref: GO:0018610 "molecular_function:dibenzofuran 4,4a-dioxygenase activity" xref: GO:0018611 "molecular_function:toluate dioxygenase activity" xref: GO:0018612 "molecular_function:dibenzothiophene dioxygenase activity" xref: GO:0018613 "molecular_function:9-fluorenone dioxygenase activity" xref: GO:0018614 "molecular_function:ethylbenzene dioxygenase activity" xref: GO:0018615 "molecular_function:2-indanone monooxygenase activity" xref: GO:0018616 "molecular_function:trihydroxytoluene dioxygenase activity" xref: GO:0018617 "molecular_function:4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity" xref: GO:0034521 "molecular_function:1-naphthoic acid dioxygenase activity" xref: GO:0034825 "molecular_function:tetralin ring-hydroxylating dioxygenase activity" xref: GO:0034906 "molecular_function:N-isopropylaniline 1,2-dixoxygenase activity" xref: GO:0034907 "molecular_function:acetanilide 1,2-dioxygenase activity" xref: GO:0034908 "molecular_function:2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity" xref: GO:0034911 "molecular_function:phthalate 3,4-dioxygenase activity" xref: GO:0034954 "molecular_function:diphenyl ether 2,3-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC07729 ! dibenzofuran relationship: has_input_compound UPa:UPC07729 {cardinality="1", is_alternate="False", is_primary="True"} ! dibenzofuran relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC03569 {cardinality="1", is_alternate="False", is_primary="True"} ! biphenyl-2,2',3-triol relationship: has_output_compound UPa:UPC03569 ! biphenyl-2,2',3-triol relationship: part_of UPa:ULS00383 ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran relationship: part_of UPa:ULS00383 {cardinality="1", order="1"} ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran [Term] id: UPa:UER00777 name: 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 2/3 namespace: enzymatic_reaction def: "1 O(2) + 1 biphenyl-2,2',3-triol => 1 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid." [] xref: EC:1.13.11 xref: GO:0016702 "molecular_function:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" xref: GO:0018542 "molecular_function:2,3-dihydroxy DDT 1,2-dioxygenase activity" xref: GO:0018555 "molecular_function:phenanthrene dioxygenase activity" xref: GO:0018556 "molecular_function:2,2',3-trihydroxybiphenyl dioxygenase activity" xref: GO:0018557 "molecular_function:1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity" xref: GO:0018558 "molecular_function:5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity" xref: GO:0018559 "molecular_function:1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity" xref: GO:0018560 "molecular_function:protocatechuate 3,4-dioxygenase type II activity" xref: GO:0018561 "molecular_function:2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity" xref: GO:0018562 "molecular_function:3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity" xref: GO:0018563 "molecular_function:2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity" xref: GO:0018564 "molecular_function:carbazole 1,9a-dioxygenase activity" xref: GO:0018565 "molecular_function:dihydroxydibenzothiophene dioxygenase activity" xref: GO:0018566 "molecular_function:1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity" xref: GO:0018567 "molecular_function:styrene dioxygenase activity" xref: GO:0018568 "molecular_function:3,4-dihydroxyphenanthrene dioxygenase activity" xref: GO:0018569 "molecular_function:hydroquinone 1,2-dioxygenase activity" xref: GO:0018570 "molecular_function:p-cumate 2,3-dioxygenase activity" xref: GO:0018571 "molecular_function:2,3-dihydroxy-p-cumate dioxygenase activity" xref: GO:0018572 "molecular_function:3,5-dichlorocatechol 1,2-dioxygenase activity" xref: GO:0018573 "molecular_function:2-aminophenol 1,6-dioxygenase activity" xref: GO:0018574 "molecular_function:2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity" xref: GO:0018575 "molecular_function:chlorocatechol 1,2-dioxygenase activity" xref: GO:0019114 "molecular_function:catechol dioxygenase activity" xref: GO:0019117 "molecular_function:dihydroxyfluorene dioxygenase activity" xref: GO:0034543 "molecular_function:5-aminosalicylate dioxygenase activity" xref: GO:0034803 "molecular_function:3-hydroxy-2-naphthoate 2,3-dioxygenase activity" xref: GO:0034806 "molecular_function:benzo(a)pyrene 11,12-dioxygenase activity" xref: GO:0034808 "molecular_function:benzo(a)pyrene 4,5-dioxygenase activity" xref: GO:0034810 "molecular_function:4,5-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034811 "molecular_function:benzo(a)pyrene 9,10-dioxygenase activity" xref: GO:0034812 "molecular_function:9,10-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034813 "molecular_function:benzo(a)pyrene 7,8-dioxygenase activity" xref: GO:0034814 "molecular_function:7,8-dihydroxy benzo(a)pyrene dioxygenase activity" xref: GO:0034827 "molecular_function:1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity" xref: GO:0034834 "molecular_function:2-mercaptobenzothiazole dioxygenase activity" xref: GO:0034895 "molecular_function:pyridine-3,4-diol dioxygenase activity" xref: GO:0034920 "molecular_function:pyrene dioxygenase activity" xref: GO:0034922 "molecular_function:4,5-dihydroxypyrene dioxygenase activity" xref: GO:0034934 "molecular_function:phenanthrene-4-carboxylate dioxygenase activity" xref: GO:0034935 "molecular_function:tetrachlorobenzene dioxygenase activity" xref: GO:0034936 "molecular_function:4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity" xref: GO:0034955 "molecular_function:2,3-dihydroxydiphenyl ether dioxygenase activity" xref: GO:0034956 "molecular_function:diphenyl ether 1,2-dioxygenase activity" xref: GO:0036403 "molecular_function:arachidonate 8(S)-lipoxygenase activity" xref: GO:0047074 "molecular_function:4-hydroxycatechol 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC03569 ! biphenyl-2,2',3-triol relationship: has_input_compound UPa:UPC03569 {cardinality="1", is_alternate="False", is_primary="True"} ! biphenyl-2,2',3-triol relationship: has_output_compound UPa:UPC07731 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_output_compound UPa:UPC07731 ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: part_of UPa:ULS00383 ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran relationship: part_of UPa:ULS00383 {cardinality="1", order="2"} ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran [Term] id: UPa:UER00778 name: 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 3/3 namespace: enzymatic_reaction def: "1 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid + 1 H(2)O => 1 2-hydroxy-2,4-pentadienoate + 1 salicylate." [] xref: EC:3.7.1.8 xref: GO:0018774 "molecular_function:2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC07731 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_input_compound UPa:UPC07731 ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_output_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00596 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00805 {cardinality="1", is_alternate="False", is_primary="True"} ! salicylate relationship: has_output_compound UPa:UPC00805 ! salicylate relationship: part_of UPa:ULS00383 ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran relationship: part_of UPa:ULS00383 {cardinality="1", order="3"} ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran [Term] id: UPa:UER00779 name: 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 1/3 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 dibenzo-p-dioxin => 1 2,2',3-trihydroxy-diphenyl ether + 1 NAD(+)." [] xref: EC:1.14.12 xref: GO:0016708 "molecular_function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor" xref: GO:0018603 "molecular_function:nitrobenzene 1,2-dioxygenase activity" xref: GO:0018604 "molecular_function:4-aminobenzoate 3,4-dioxygenase (deaminating) activity" xref: GO:0018606 "molecular_function:benzenesulfonate dioxygenase activity" xref: GO:0018607 "molecular_function:1-indanone monooxygenase activity" xref: GO:0018608 "molecular_function:1-indanone dioxygenase activity" xref: GO:0018609 "molecular_function:chlorobenzene dioxygenase activity" xref: GO:0018610 "molecular_function:dibenzofuran 4,4a-dioxygenase activity" xref: GO:0018611 "molecular_function:toluate dioxygenase activity" xref: GO:0018612 "molecular_function:dibenzothiophene dioxygenase activity" xref: GO:0018613 "molecular_function:9-fluorenone dioxygenase activity" xref: GO:0018614 "molecular_function:ethylbenzene dioxygenase activity" xref: GO:0018615 "molecular_function:2-indanone monooxygenase activity" xref: GO:0018616 "molecular_function:trihydroxytoluene dioxygenase activity" xref: GO:0018617 "molecular_function:4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity" xref: GO:0034521 "molecular_function:1-naphthoic acid dioxygenase activity" xref: GO:0034825 "molecular_function:tetralin ring-hydroxylating dioxygenase activity" xref: GO:0034906 "molecular_function:N-isopropylaniline 1,2-dixoxygenase activity" xref: GO:0034907 "molecular_function:acetanilide 1,2-dioxygenase activity" xref: GO:0034908 "molecular_function:2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity" xref: GO:0034911 "molecular_function:phthalate 3,4-dioxygenase activity" xref: GO:0034954 "molecular_function:diphenyl ether 2,3-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC07732 {cardinality="1", is_alternate="False", is_primary="True"} ! dibenzo-p-dioxin relationship: has_input_compound UPa:UPC07732 ! dibenzo-p-dioxin relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC07733 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,2',3-trihydroxy-diphenyl ether relationship: has_output_compound UPa:UPC07733 ! 2,2',3-trihydroxy-diphenyl ether relationship: part_of UPa:ULS00384 ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin relationship: part_of UPa:ULS00384 {cardinality="1", order="1"} ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin [Term] id: UPa:UER00780 name: 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 2/3 namespace: enzymatic_reaction def: "1 2,2',3-trihydroxy-diphenyl ether + 1 O(2) => 1 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid." [] xref: EC:1.13.11 xref: GO:0016702 "molecular_function:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" xref: GO:0018542 "molecular_function:2,3-dihydroxy DDT 1,2-dioxygenase activity" xref: GO:0018555 "molecular_function:phenanthrene dioxygenase activity" xref: GO:0018556 "molecular_function:2,2',3-trihydroxybiphenyl dioxygenase activity" xref: GO:0018557 "molecular_function:1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity" xref: GO:0018558 "molecular_function:5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity" xref: GO:0018559 "molecular_function:1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity" xref: GO:0018560 "molecular_function:protocatechuate 3,4-dioxygenase type II activity" xref: GO:0018561 "molecular_function:2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity" xref: GO:0018562 "molecular_function:3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity" xref: GO:0018563 "molecular_function:2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity" xref: GO:0018564 "molecular_function:carbazole 1,9a-dioxygenase activity" xref: GO:0018565 "molecular_function:dihydroxydibenzothiophene dioxygenase activity" xref: GO:0018566 "molecular_function:1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity" xref: GO:0018567 "molecular_function:styrene dioxygenase activity" xref: GO:0018568 "molecular_function:3,4-dihydroxyphenanthrene dioxygenase activity" xref: GO:0018569 "molecular_function:hydroquinone 1,2-dioxygenase activity" xref: GO:0018570 "molecular_function:p-cumate 2,3-dioxygenase activity" xref: GO:0018571 "molecular_function:2,3-dihydroxy-p-cumate dioxygenase activity" xref: GO:0018572 "molecular_function:3,5-dichlorocatechol 1,2-dioxygenase activity" xref: GO:0018573 "molecular_function:2-aminophenol 1,6-dioxygenase activity" xref: GO:0018574 "molecular_function:2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity" xref: GO:0018575 "molecular_function:chlorocatechol 1,2-dioxygenase activity" xref: GO:0019114 "molecular_function:catechol dioxygenase activity" xref: GO:0019117 "molecular_function:dihydroxyfluorene dioxygenase activity" xref: GO:0034543 "molecular_function:5-aminosalicylate dioxygenase activity" xref: GO:0034803 "molecular_function:3-hydroxy-2-naphthoate 2,3-dioxygenase activity" xref: GO:0034806 "molecular_function:benzo(a)pyrene 11,12-dioxygenase activity" xref: GO:0034808 "molecular_function:benzo(a)pyrene 4,5-dioxygenase activity" xref: GO:0034810 "molecular_function:4,5-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034811 "molecular_function:benzo(a)pyrene 9,10-dioxygenase activity" xref: GO:0034812 "molecular_function:9,10-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034813 "molecular_function:benzo(a)pyrene 7,8-dioxygenase activity" xref: GO:0034814 "molecular_function:7,8-dihydroxy benzo(a)pyrene dioxygenase activity" xref: GO:0034827 "molecular_function:1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity" xref: GO:0034834 "molecular_function:2-mercaptobenzothiazole dioxygenase activity" xref: GO:0034895 "molecular_function:pyridine-3,4-diol dioxygenase activity" xref: GO:0034920 "molecular_function:pyrene dioxygenase activity" xref: GO:0034922 "molecular_function:4,5-dihydroxypyrene dioxygenase activity" xref: GO:0034934 "molecular_function:phenanthrene-4-carboxylate dioxygenase activity" xref: GO:0034935 "molecular_function:tetrachlorobenzene dioxygenase activity" xref: GO:0034936 "molecular_function:4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity" xref: GO:0034955 "molecular_function:2,3-dihydroxydiphenyl ether dioxygenase activity" xref: GO:0034956 "molecular_function:diphenyl ether 1,2-dioxygenase activity" xref: GO:0036403 "molecular_function:arachidonate 8(S)-lipoxygenase activity" xref: GO:0047074 "molecular_function:4-hydroxycatechol 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC07733 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,2',3-trihydroxy-diphenyl ether relationship: has_input_compound UPa:UPC07733 ! 2,2',3-trihydroxy-diphenyl ether relationship: has_output_compound UPa:UPC07734 ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_output_compound UPa:UPC07734 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: part_of UPa:ULS00384 {cardinality="1", order="2"} ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin relationship: part_of UPa:ULS00384 ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin [Term] id: UPa:UER00781 name: 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 3/3 namespace: enzymatic_reaction def: "1 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid + 1 H(2)O => 1 2-hydroxymuconate + 1 catechol." [] xref: EC:3.7.1 xref: GO:0016823 "molecular_function:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances" xref: GO:0018736 "molecular_function:6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity" xref: GO:0018737 "molecular_function:2-ketocyclohexane-1-carboxyl-CoA hydrolase activity" xref: GO:0018765 "molecular_function:2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity" xref: GO:0018766 "molecular_function:dihydrophloroglucinol hydrolase activity" xref: GO:0018767 "molecular_function:2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity" xref: GO:0018768 "molecular_function:2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity" xref: GO:0018769 "molecular_function:2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity" xref: GO:0018770 "molecular_function:6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity" xref: GO:0018772 "molecular_function:trioxoheptanoate hydrolase activity" xref: GO:0034545 "molecular_function:fumarylpyruvate hydrolase activity" xref: GO:0034779 "molecular_function:4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity" xref: GO:0034789 "molecular_function:2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity" xref: GO:0034801 "molecular_function:2,4-dinitrocyclohexanone hydrolase activity" xref: GO:0034820 "molecular_function:4,9-DSHA hydrolase activity" xref: GO:0034828 "molecular_function:4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity" xref: GO:0034910 "molecular_function:6-hydroxy-3-succinoylpyridine hydrolase activity" xref: GO:0034948 "molecular_function:2,6-dihydroxypseudooxynicotine hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC07734 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_input_compound UPa:UPC07734 ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_output_compound UPa:UPC00090 ! catechol relationship: has_output_compound UPa:UPC00090 {cardinality="1", is_alternate="False", is_primary="True"} ! catechol relationship: has_output_compound UPa:UPC02501 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxymuconate relationship: has_output_compound UPa:UPC02501 ! 2-hydroxymuconate relationship: part_of UPa:ULS00384 ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin relationship: part_of UPa:ULS00384 {cardinality="1", order="3"} ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin [Term] id: UPa:UER00782 name: D-sorbitol 6-phosphate from D-sorbitol: step 1/1 namespace: enzymatic_reaction def: "1 D-sorbitol + 1 protein N(pi)-phospho-L-histidine => 1 D-sorbitol 6-phosphate + 1 protein-L-histidine." [] xref: EC:2.7.1.69 xref: GO:0008982 "molecular_function:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00794 {cardinality="1", is_alternate="False", is_primary="True"} ! D-sorbitol relationship: has_input_compound UPa:UPC00794 ! D-sorbitol relationship: has_input_compound UPa:UPC04261 {cardinality="1", is_alternate="False", is_primary="False"} ! protein N(pi)-phospho-L-histidine relationship: has_input_compound UPa:UPC04261 ! protein N(pi)-phospho-L-histidine relationship: has_output_compound UPa:UPC00615 ! protein-L-histidine relationship: has_output_compound UPa:UPC00615 {cardinality="1", is_alternate="False", is_primary="False"} ! protein-L-histidine relationship: has_output_compound UPa:UPC01096 {cardinality="1", is_alternate="False", is_primary="True"} ! D-sorbitol 6-phosphate relationship: has_output_compound UPa:UPC01096 ! D-sorbitol 6-phosphate relationship: part_of UPa:ULS00385 ! D-sorbitol 6-phosphate from D-sorbitol relationship: part_of UPa:ULS00385 {cardinality="1", order="1"} ! D-sorbitol 6-phosphate from D-sorbitol [Term] id: UPa:UER00783 name: D-fructose 6-phosphate from D-sorbitol 6-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 D-sorbitol 6-phosphate + 1 NAD(+) => 1 D-fructose 6-phosphate + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.140 xref: GO:0009010 "molecular_function:sorbitol-6-phosphate 2-dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC01096 ! D-sorbitol 6-phosphate relationship: has_input_compound UPa:UPC01096 {cardinality="1", is_alternate="False", is_primary="True"} ! D-sorbitol 6-phosphate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 6-phosphate relationship: part_of UPa:ULS00386 {cardinality="1", order="1"} ! D-fructose 6-phosphate from D-sorbitol 6-phosphate relationship: part_of UPa:ULS00386 ! D-fructose 6-phosphate from D-sorbitol 6-phosphate [Term] id: UPa:UER00784 name: D-sorbitol from D-fructose and D-glucose: step 1/1 namespace: enzymatic_reaction def: "1 D-fructose + 1 D-glucose => 1 D-glucono-1,5-lactone + 1 D-sorbitol." [] xref: EC:1.1.99.28 xref: GO:0047061 "molecular_function:glucose-fructose oxidoreductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00031 ! D-glucose relationship: has_input_compound UPa:UPC00031 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucose relationship: has_input_compound UPa:UPC00095 ! D-fructose relationship: has_input_compound UPa:UPC00095 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose relationship: has_output_compound UPa:UPC00198 {cardinality="1", is_alternate="False", is_primary="False"} ! D-glucono-1,5-lactone relationship: has_output_compound UPa:UPC00198 ! D-glucono-1,5-lactone relationship: has_output_compound UPa:UPC00794 {cardinality="1", is_alternate="False", is_primary="True"} ! D-sorbitol relationship: has_output_compound UPa:UPC00794 ! D-sorbitol relationship: part_of UPa:ULS00387 {cardinality="1", order="1"} ! D-sorbitol from D-fructose and D-glucose relationship: part_of UPa:ULS00387 ! D-sorbitol from D-fructose and D-glucose [Term] id: UPa:UER00785 name: D-gluconate from D-glucono-1,5-lactone: step 1/1 namespace: enzymatic_reaction def: "1 D-glucono-1,5-lactone + 1 H(2)O => 1 D-gluconate." [] xref: EC:3.1.1.17 xref: GO:0004341 "molecular_function:gluconolactonase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00198 ! D-glucono-1,5-lactone relationship: has_input_compound UPa:UPC00198 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucono-1,5-lactone relationship: has_output_compound UPa:UPC00257 ! D-gluconate relationship: has_output_compound UPa:UPC00257 {cardinality="1", is_alternate="False", is_primary="True"} ! D-gluconate relationship: part_of UPa:ULS00388 {cardinality="1", order="1"} ! D-gluconate from D-glucono-1,5-lactone relationship: part_of UPa:ULS00388 ! D-gluconate from D-glucono-1,5-lactone [Term] id: UPa:UER00786 name: histamine from L-histidine: step 1/1 namespace: enzymatic_reaction def: "1 L-histidine => 1 CO(2) + 1 histamine." [] xref: EC:4.1.1.22 xref: GO:0004398 "molecular_function:histidine decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00135 ! L-histidine relationship: has_input_compound UPa:UPC00135 {cardinality="1", is_alternate="False", is_primary="True"} ! L-histidine relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00388 {cardinality="1", is_alternate="False", is_primary="True"} ! histamine relationship: has_output_compound UPa:UPC00388 ! histamine relationship: part_of UPa:ULS00389 {cardinality="1", order="1"} ! histamine from L-histidine relationship: part_of UPa:ULS00389 ! histamine from L-histidine [Term] id: UPa:UER00787 name: myo-inositol from D-glucose 6-phosphate: step 1/2 namespace: enzymatic_reaction def: "1 D-glucose 6-phosphate => 1 1D-myo-inositol 3-phosphate." [] xref: EC:5.5.1.4 xref: GO:0004512 "molecular_function:inositol-3-phosphate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_input_compound UPa:UPC00092 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC04006 {cardinality="1", is_alternate="False", is_primary="True"} ! 1D-myo-inositol 3-phosphate relationship: has_output_compound UPa:UPC04006 ! 1D-myo-inositol 3-phosphate relationship: part_of UPa:ULS00390 {cardinality="1", order="1"} ! myo-inositol from D-glucose 6-phosphate relationship: part_of UPa:ULS00390 ! myo-inositol from D-glucose 6-phosphate [Term] id: UPa:UER00788 name: myo-inositol from D-glucose 6-phosphate: step 2/2 namespace: enzymatic_reaction def: "1 1D-myo-inositol 3-phosphate + 1 H(2)O => 1 myo-inositol + 1 phosphate." [] xref: EC:3.1.3.25 xref: GO:0008934 "molecular_function:inositol monophosphate 1-phosphatase activity" xref: GO:0052832 "molecular_function:inositol monophosphate 3-phosphatase activity" xref: GO:0052833 "molecular_function:inositol monophosphate 4-phosphatase activity" xref: GO:0052834 "molecular_function:inositol monophosphate phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC04006 ! 1D-myo-inositol 3-phosphate relationship: has_input_compound UPa:UPC04006 {cardinality="1", is_alternate="False", is_primary="True"} ! 1D-myo-inositol 3-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00137 {cardinality="1", is_alternate="False", is_primary="True"} ! myo-inositol relationship: has_output_compound UPa:UPC00137 ! myo-inositol relationship: part_of UPa:ULS00390 {cardinality="1", order="2"} ! myo-inositol from D-glucose 6-phosphate relationship: part_of UPa:ULS00390 ! myo-inositol from D-glucose 6-phosphate [Term] id: UPa:UER00789 name: trans-4-coumarate from trans-cinnamate: step 1/1 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 O(2) + 1 trans-cinnamate => 1 H(2)O + 1 NADP(+) + 1 trans-4-coumarate." [] xref: EC:1.14.13.11 xref: GO:0016710 "molecular_function:trans-cinnamate 4-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00423 ! trans-cinnamate relationship: has_input_compound UPa:UPC00423 {cardinality="1", is_alternate="False", is_primary="True"} ! trans-cinnamate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00811 {cardinality="1", is_alternate="False", is_primary="True"} ! trans-4-coumarate relationship: has_output_compound UPa:UPC00811 ! trans-4-coumarate relationship: part_of UPa:ULS00391 {cardinality="1", order="1"} ! trans-4-coumarate from trans-cinnamate relationship: part_of UPa:ULS00391 ! trans-4-coumarate from trans-cinnamate [Term] id: UPa:UER00790 name: nicotinate from nicotinamide: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 nicotinamide => 1 NH(3) + 1 nicotinate." [] xref: EC:3.5.1.19 xref: GO:0008936 "molecular_function:nicotinamidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00153 ! nicotinamide relationship: has_input_compound UPa:UPC00153 {cardinality="1", is_alternate="False", is_primary="True"} ! nicotinamide relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00253 {cardinality="1", is_alternate="False", is_primary="True"} ! nicotinate relationship: has_output_compound UPa:UPC00253 ! nicotinate relationship: part_of UPa:ULS00392 ! nicotinate from nicotinamide relationship: part_of UPa:ULS00392 {cardinality="1", order="1"} ! nicotinate from nicotinamide [Term] id: UPa:UER00791 name: 3-(2,3-dihydroxyphenyl)propanoate from 3-(3-hydroxyphenyl)propanoate: step 1/1 namespace: enzymatic_reaction def: "1 3-(3-hydroxyphenyl)propanoate + 1 H(+) + 1 NADH + 1 O(2) => 1 3-(2,3-dihydroxyphenyl)propanoate + 1 H(2)O + 1 NAD(+)." [] xref: EC:1.14.13.127 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC11457 ! 3-(3-hydroxyphenyl)propanoate relationship: has_input_compound UPa:UPC11457 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-(3-hydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC04044 ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC04044 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-(2,3-dihydroxyphenyl)propanoate relationship: part_of UPa:ULS00394 {cardinality="1", order="1"} ! 3-(2,3-dihydroxyphenyl)propanoate from 3-(3-hydroxyphenyl)propanoate relationship: part_of UPa:ULS00394 ! 3-(2,3-dihydroxyphenyl)propanoate from 3-(3-hydroxyphenyl)propanoate [Term] id: UPa:UER00792 name: 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate: step 1/2 namespace: enzymatic_reaction def: "1 3-phenylpropanoate + 1 H(+) + 1 NADH + 1 O(2) => 1 NAD(+) + 1 cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol." [] xref: EC:1.14.12.19 xref: GO:0008695 "molecular_function:3-phenylpropionate dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC05629 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phenylpropanoate relationship: has_input_compound UPa:UPC05629 ! 3-phenylpropanoate relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC11588 ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol relationship: has_output_compound UPa:UPC11588 {cardinality="1", is_alternate="False", is_primary="True"} ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol relationship: part_of UPa:ULS00395 {cardinality="1", order="1"} ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate relationship: part_of UPa:ULS00395 ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate [Term] id: UPa:UER00793 name: 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate: step 2/2 namespace: enzymatic_reaction def: "1 NAD(+) + 1 cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol => 1 3-(2,3-dihydroxyphenyl)propanoate + 1 H(+) + 1 NADH." [] xref: EC:1.3.1.87 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC11588 {cardinality="1", is_alternate="False", is_primary="True"} ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol relationship: has_input_compound UPa:UPC11588 ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC04044 ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC04044 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-(2,3-dihydroxyphenyl)propanoate relationship: part_of UPa:ULS00395 ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate relationship: part_of UPa:ULS00395 {cardinality="1", order="2"} ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate [Term] id: UPa:UER00794 name: acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 1/4 namespace: enzymatic_reaction def: "1 3-(2,3-dihydroxyphenyl)propanoate + 1 O(2) => 1 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate." [] xref: EC:1.13.11.16 xref: GO:0047070 "molecular_function:3-carboxyethylcatechol 2,3-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC04044 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_input_compound UPa:UPC04044 ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC04479 ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate relationship: has_output_compound UPa:UPC04479 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate relationship: part_of UPa:ULS00396 ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate relationship: part_of UPa:ULS00396 {cardinality="1", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate [Term] id: UPa:UER00795 name: acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 2/4 namespace: enzymatic_reaction def: "1 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + 1 H(2)O => 1 2-hydroxy-2,4-pentadienoate + 1 succinate." [] xref: EC:3.7.1.14 xref: GO:0018771 "molecular_function:2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity" xref: GO:0052823 "molecular_function:2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04479 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate relationship: has_input_compound UPa:UPC04479 ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00596 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-2,4-pentadienoate relationship: part_of UPa:ULS00396 ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate relationship: part_of UPa:ULS00396 {cardinality="1", order="2"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate [Term] id: UPa:UER00796 name: acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 3/4 namespace: enzymatic_reaction def: "1 2-hydroxy-2,4-pentadienoate + 1 H(2)O => 1 4-hydroxy-2-oxopentanoate." [] xref: EC:4.2.1.80 xref: GO:0008684 "molecular_function:2-oxopent-4-enoate hydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: has_input_compound UPa:UPC00596 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC03589 ! 4-hydroxy-2-oxopentanoate relationship: has_output_compound UPa:UPC03589 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-hydroxy-2-oxopentanoate relationship: part_of UPa:ULS00396 ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate relationship: part_of UPa:ULS00396 {cardinality="1", order="3"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate [Term] id: UPa:UER00797 name: acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 4/4 namespace: enzymatic_reaction def: "1 4-hydroxy-2-oxopentanoate => 1 acetaldehyde + 1 pyruvate." [] xref: EC:4.1.3.39 xref: GO:0008701 "molecular_function:4-hydroxy-2-oxovalerate aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03589 ! 4-hydroxy-2-oxopentanoate relationship: has_input_compound UPa:UPC03589 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-hydroxy-2-oxopentanoate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00084 {cardinality="1", is_alternate="False", is_primary="True"} ! acetaldehyde relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: part_of UPa:ULS00396 ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate relationship: part_of UPa:ULS00396 {cardinality="1", order="4"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate [Term] id: UPa:UER00798 name: acetyl-CoA from acetaldehyde: step 1/1 namespace: enzymatic_reaction def: "1 CoA + 1 NAD(+) + 1 acetaldehyde => 1 H(+) + 1 NADH + 1 acetyl-CoA." [] xref: EC:1.2.1.10 xref: GO:0008774 "molecular_function:acetaldehyde dehydrogenase (acetylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00084 ! acetaldehyde relationship: has_input_compound UPa:UPC00084 {cardinality="1", is_alternate="False", is_primary="True"} ! acetaldehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:ULS00397 ! acetyl-CoA from acetaldehyde relationship: part_of UPa:ULS00397 {cardinality="1", order="1"} ! acetyl-CoA from acetaldehyde [Term] id: UPa:UER00799 name: serotonin from L-tryptophan: step 1/2 namespace: enzymatic_reaction def: "1 L-tryptophan + 1 O(2) + 1 tetrahydrobiopterin => 1 4a-hydroxytetrahydrobiopterin + 1 5-hydroxy-L-tryptophan." [] xref: EC:1.14.16.4 xref: GO:0004510 "molecular_function:tryptophan 5-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00078 ! L-tryptophan relationship: has_input_compound UPa:UPC00078 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tryptophan relationship: has_input_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: has_input_compound UPa:UPC00272 {cardinality="1", is_alternate="False", is_primary="False"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00643 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-hydroxy-L-tryptophan relationship: has_output_compound UPa:UPC00643 ! 5-hydroxy-L-tryptophan relationship: has_output_compound UPa:UPC15522 ! 4a-hydroxytetrahydrobiopterin relationship: has_output_compound UPa:UPC15522 {cardinality="1", is_alternate="False", is_primary="False"} ! 4a-hydroxytetrahydrobiopterin relationship: part_of UPa:ULS00398 ! serotonin from L-tryptophan relationship: part_of UPa:ULS00398 {cardinality="1", order="1"} ! serotonin from L-tryptophan [Term] id: UPa:UER00800 name: 2-hydroxy-3-oxosuccinate from L-tartrate: step 1/1 namespace: enzymatic_reaction def: "1 L-tartrate + 1 NAD(+) => 1 2-hydroxy-3-oxosuccinate + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.93 xref: GO:0009027 "molecular_function:tartrate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00898 ! L-tartrate relationship: has_input_compound UPa:UPC00898 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tartrate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC03459 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxosuccinate relationship: has_output_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate relationship: part_of UPa:ULS00399 {cardinality="1", order="1"} ! 2-hydroxy-3-oxosuccinate from L-tartrate relationship: part_of UPa:ULS00399 ! 2-hydroxy-3-oxosuccinate from L-tartrate [Term] id: UPa:UER00801 name: 2-hydroxy-3-oxosuccinate from meso-tartrate: step 1/1 namespace: enzymatic_reaction def: "1 NAD(+) + 1 meso-tartrate => 1 2-hydroxy-3-oxosuccinate + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.93 xref: GO:0009027 "molecular_function:tartrate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00552 {cardinality="1", is_alternate="False", is_primary="True"} ! meso-tartrate relationship: has_input_compound UPa:UPC00552 ! meso-tartrate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC03459 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxosuccinate relationship: has_output_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate relationship: part_of UPa:ULS00400 ! 2-hydroxy-3-oxosuccinate from meso-tartrate relationship: part_of UPa:ULS00400 {cardinality="1", order="1"} ! 2-hydroxy-3-oxosuccinate from meso-tartrate [Term] id: UPa:UER00802 name: D-glycerate from 2-hydroxy-3-oxosuccinate: step 1/1 namespace: enzymatic_reaction def: "2-hydroxy-3-oxosuccinate + H(+) + [NADH or NADPH] => CO(2) + D-glycerate + [NAD(+) or NADP(+)]." [] xref: EC:1.1.1.92 xref: GO:0047047 "molecular_function:oxaloglycolate reductase (decarboxylating) activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00981 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00982 ! None relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate relationship: has_input_compound UPa:UPC03459 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxosuccinate relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: part_of UPa:ULS00401 ! D-glycerate from 2-hydroxy-3-oxosuccinate relationship: part_of UPa:ULS00401 {cardinality="1", order="1"} ! D-glycerate from 2-hydroxy-3-oxosuccinate [Term] id: UPa:UER00803 name: D-glycerate from L-tartrate: step 1/1 namespace: enzymatic_reaction def: "1 L-tartrate => 1 CO(2) + 1 D-glycerate." [] xref: EC:4.1.1.73 xref: GO:0050319 "molecular_function:tartrate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00898 ! L-tartrate relationship: has_input_compound UPa:UPC00898 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tartrate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: part_of UPa:ULS00402 ! D-glycerate from L-tartrate relationship: part_of UPa:ULS00402 {cardinality="1", order="1"} ! D-glycerate from L-tartrate [Term] id: UPa:UER00804 name: 3-hydroxypyruvate from D-glycerate: step 1/1 namespace: enzymatic_reaction def: "D-glycerate + [NAD(+) or NADP(+)] => 3-hydroxypyruvate + H(+) + [NADH or NADPH]." [] xref: EC:1.1.1.29 xref: EC:1.1.1.81 xref: GO:0008465 "molecular_function:glycerate dehydrogenase activity" xref: GO:0016618 "molecular_function:hydroxypyruvate reductase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00983 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00984 ! None relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_input_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00168 ! 3-hydroxypyruvate relationship: has_output_compound UPa:UPC00168 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxypyruvate relationship: part_of UPa:ULS00403 ! 3-hydroxypyruvate from D-glycerate relationship: part_of UPa:ULS00403 {cardinality="1", order="1"} ! 3-hydroxypyruvate from D-glycerate [Term] id: UPa:UER00805 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole from thiamine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 thiamine => 1 4-amino-5-hydroxymethyl-2-methylpyrimidine + 1 5-(2-hydroxyethyl)-4-methylthiazole + 1 H(+)." [] xref: EC:3.5.99.2 xref: GO:0050334 "molecular_function:thiaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00378 ! thiamine relationship: has_input_compound UPa:UPC00378 {cardinality="1", is_alternate="False", is_primary="True"} ! thiamine relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC01279 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC01279 ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC04294 ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: has_output_compound UPa:UPC04294 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: part_of UPa:ULS00404 ! 4-amino-5-hydroxymethyl-2-methylpyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole from thiamine relationship: part_of UPa:ULS00404 {cardinality="1", order="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole from thiamine [Term] id: UPa:UER00806 name: taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate: step 1/2 namespace: enzymatic_reaction def: "1 geranylgeranyl diphosphate => 1 diphosphate + 1 taxa-4,11-diene." [] xref: EC:4.2.3.17 xref: GO:0050553 "molecular_function:taxadiene synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00353 ! geranylgeranyl diphosphate relationship: has_input_compound UPa:UPC00353 {cardinality="1", is_alternate="False", is_primary="True"} ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC11894 {cardinality="1", is_alternate="False", is_primary="True"} ! taxa-4,11-diene relationship: has_output_compound UPa:UPC11894 ! taxa-4,11-diene relationship: part_of UPa:ULS00405 ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate relationship: part_of UPa:ULS00405 {cardinality="1", order="1"} ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate [Term] id: UPa:UER00807 name: taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate: step 2/2 namespace: enzymatic_reaction def: "1 O(2) + 1 reduced acceptor + 1 taxa-4,11-diene => 1 H(2)O + 1 acceptor + 1 taxa-4(20),11-dien-5alpha-ol." [] xref: EC:1.14.99.37 xref: GO:0050604 "molecular_function:taxadiene 5-alpha-hydroxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00030 ! reduced acceptor relationship: has_input_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_input_compound UPa:UPC11894 ! taxa-4,11-diene relationship: has_input_compound UPa:UPC11894 {cardinality="1", is_alternate="False", is_primary="True"} ! taxa-4,11-diene relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_output_compound UPa:UPC00028 ! acceptor relationship: has_output_compound UPa:UPC11895 {cardinality="1", is_alternate="False", is_primary="True"} ! taxa-4(20),11-dien-5alpha-ol relationship: has_output_compound UPa:UPC11895 ! taxa-4(20),11-dien-5alpha-ol relationship: part_of UPa:ULS00405 ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate relationship: part_of UPa:ULS00405 {cardinality="1", order="2"} ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate [Term] id: UPa:UER00808 name: 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 1/3 namespace: enzymatic_reaction def: "1 acetyl-CoA + 1 taxa-4(20),11-dien-5alpha-ol => 1 CoA + 1 taxa-4(20),11-dien-5alpha-yl acetate." [] xref: EC:2.3.1.162 xref: GO:0050638 "molecular_function:taxadien-5-alpha-ol O-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC11895 ! taxa-4(20),11-dien-5alpha-ol relationship: has_input_compound UPa:UPC11895 {cardinality="1", is_alternate="False", is_primary="True"} ! taxa-4(20),11-dien-5alpha-ol relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC11896 {cardinality="1", is_alternate="False", is_primary="True"} ! taxa-4(20),11-dien-5alpha-yl acetate relationship: has_output_compound UPa:UPC11896 ! taxa-4(20),11-dien-5alpha-yl acetate relationship: part_of UPa:ULS00406 {cardinality="1", order="1"} ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol relationship: part_of UPa:ULS00406 ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol [Term] id: UPa:UER00809 name: 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 2/3 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 O(2) + 1 taxa-4(20),11-dien-5alpha-yl acetate => 1 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.76 xref: GO:0050597 "molecular_function:taxane 10-beta-hydroxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC11896 ! taxa-4(20),11-dien-5alpha-yl acetate relationship: has_input_compound UPa:UPC11896 {cardinality="1", is_alternate="False", is_primary="True"} ! taxa-4(20),11-dien-5alpha-yl acetate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC11898 {cardinality="1", is_alternate="False", is_primary="True"} ! 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate relationship: has_output_compound UPa:UPC11898 ! 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate relationship: part_of UPa:ULS00406 {cardinality="1", order="2"} ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol relationship: part_of UPa:ULS00406 ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol [Term] id: UPa:UER00810 name: baccatin III from 10-deacetyl-2-debenzoylbaccatin III: step 1/2 namespace: enzymatic_reaction def: "1 10-deacetyl-2-debenzoylbaccatin III + 1 benzoyl-CoA => 1 10-deacetylbaccatin III + 1 CoA." [] xref: EC:2.3.1.166 xref: GO:0050642 "molecular_function:2-alpha-hydroxytaxane 2-O-benzoyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00512 ! benzoyl-CoA relationship: has_input_compound UPa:UPC00512 {cardinality="1", is_alternate="False", is_primary="False"} ! benzoyl-CoA relationship: has_input_compound UPa:UPC11899 ! 10-deacetyl-2-debenzoylbaccatin III relationship: has_input_compound UPa:UPC11899 {cardinality="1", is_alternate="False", is_primary="True"} ! 10-deacetyl-2-debenzoylbaccatin III relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC11700 ! 10-deacetylbaccatin III relationship: has_output_compound UPa:UPC11700 {cardinality="1", is_alternate="False", is_primary="True"} ! 10-deacetylbaccatin III relationship: part_of UPa:ULS00407 {cardinality="1", order="1"} ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III relationship: part_of UPa:ULS00407 ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III [Term] id: UPa:UER00811 name: baccatin III from 10-deacetyl-2-debenzoylbaccatin III: step 2/2 namespace: enzymatic_reaction def: "1 10-deacetylbaccatin III + 1 acetyl-CoA => 1 CoA + 1 baccatin III." [] xref: EC:2.3.1.167 xref: GO:0050643 "molecular_function:10-deacetylbaccatin III 10-O-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC11700 {cardinality="1", is_alternate="False", is_primary="True"} ! 10-deacetylbaccatin III relationship: has_input_compound UPa:UPC11700 ! 10-deacetylbaccatin III relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC11900 ! baccatin III relationship: has_output_compound UPa:UPC11900 {cardinality="1", is_alternate="False", is_primary="True"} ! baccatin III relationship: part_of UPa:ULS00407 {cardinality="1", order="2"} ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III relationship: part_of UPa:ULS00407 ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III [Term] id: UPa:UER00812 name: taxol from baccatin III: step 1/3 namespace: enzymatic_reaction def: "1 baccatin III + 1 beta-phenylalanoyl-CoA => 1 CoA + 1 N-(3'R)-debenzoyl-2'-deoxytaxol." [] xref: EC:2.3 xref: GO:0016746 "molecular_function:transferase activity, transferring acyl groups" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC11900 ! baccatin III relationship: has_input_compound UPa:UPC11900 {cardinality="1", is_alternate="False", is_primary="True"} ! baccatin III relationship: has_input_compound UPa:UPC16833 {cardinality="1", is_alternate="False", is_primary="False"} ! beta-phenylalanoyl-CoA relationship: has_input_compound UPa:UPC16833 ! beta-phenylalanoyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC16523 {cardinality="1", is_alternate="False", is_primary="True"} ! N-(3'R)-debenzoyl-2'-deoxytaxol relationship: has_output_compound UPa:UPC16523 ! N-(3'R)-debenzoyl-2'-deoxytaxol relationship: part_of UPa:ULS00408 {cardinality="1", order="1"} ! taxol from baccatin III relationship: part_of UPa:ULS00408 ! taxol from baccatin III [Term] id: UPa:UER00813 name: taxol from baccatin III: step 2/3 namespace: enzymatic_reaction def: "1 N-(3'R)-debenzoyl-2'-deoxytaxol + 1 O(2) + 1 reduced acceptor => 1 H(2)O + 1 N-(3'R)-debenzoyltaxol + 1 acceptor." [] xref: EC:1.14 xref: GO:0016705 "molecular_function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" xref: GO:0018585 "molecular_function:fluorene oxygenase activity" xref: GO:0018586 "molecular_function:mono-butyltin dioxygenase activity" xref: GO:0018588 "molecular_function:tri-n-butyltin dioxygenase activity" xref: GO:0018589 "molecular_function:di-n-butyltin dioxygenase activity" xref: GO:0018590 "molecular_function:methylsilanetriol hydroxylase activity" xref: GO:0018591 "molecular_function:methyl tertiary butyl ether 3-monooxygenase activity" xref: GO:0018592 "molecular_function:4-nitrocatechol 4-monooxygenase activity" xref: GO:0018593 "molecular_function:4-chlorophenoxyacetate monooxygenase activity" xref: GO:0018594 "molecular_function:tert-butanol 2-monooxygenase activity" xref: GO:0018595 "molecular_function:alpha-pinene monooxygenase activity" xref: GO:0018596 "molecular_function:dimethylsilanediol hydroxylase activity" xref: GO:0018597 "molecular_function:ammonia monooxygenase activity" xref: GO:0018598 "molecular_function:hydroxymethylsilanetriol oxidase activity" xref: GO:0018599 "molecular_function:2-hydroxyisobutyrate 3-monooxygenase activity" xref: GO:0018600 "molecular_function:alpha-pinene dehydrogenase activity" xref: GO:0034559 "molecular_function:bisphenol A hydroxylase B activity" xref: GO:0034562 "molecular_function:2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity" xref: GO:0034786 "molecular_function:9-fluorenone-3,4-dioxygenase activity" xref: GO:0034816 "molecular_function:anthracene 9,10-dioxygenase activity" xref: GO:0034857 "molecular_function:2-(methylthio)benzothiazole monooxygenase activity" xref: GO:0034858 "molecular_function:2-hydroxybenzothiazole monooxygenase activity" xref: GO:0034859 "molecular_function:benzothiazole monooxygenase activity" xref: GO:0034862 "molecular_function:2,6-dihydroxybenzothiazole monooxygenase activity" xref: GO:0034870 "molecular_function:pinacolone 5-monooxygenase activity" xref: GO:0034873 "molecular_function:thioacetamide S-oxygenase activity" xref: GO:0034874 "molecular_function:thioacetamide S-oxide S-oxygenase activity" xref: GO:0034888 "molecular_function:endosulfan monooxygenase I activity" xref: GO:0034893 "molecular_function:N-nitrodimethylamine hydroxylase activity" xref: GO:0034897 "molecular_function:4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity" xref: GO:0034903 "molecular_function:endosulfan ether monooxygenase activity" xref: GO:0034925 "molecular_function:pyrene 4,5-monooxygenase activity" xref: GO:0034927 "molecular_function:pyrene 1,2-monooxygenase activity" xref: GO:0034928 "molecular_function:1-hydroxypyrene 6,7-monooxygenase activity" xref: GO:0034929 "molecular_function:1-hydroxypyrene 7,8-monooxygenase activity" xref: GO:0034950 "molecular_function:phenylboronic acid monooxygenase activity" xref: GO:0043823 "molecular_function:spheroidene monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_input_compound UPa:UPC00030 ! reduced acceptor relationship: has_input_compound UPa:UPC16523 ! N-(3'R)-debenzoyl-2'-deoxytaxol relationship: has_input_compound UPa:UPC16523 {cardinality="1", is_alternate="False", is_primary="True"} ! N-(3'R)-debenzoyl-2'-deoxytaxol relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00028 ! acceptor relationship: has_output_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_output_compound UPa:UPC16524 {cardinality="1", is_alternate="False", is_primary="True"} ! N-(3'R)-debenzoyltaxol relationship: has_output_compound UPa:UPC16524 ! N-(3'R)-debenzoyltaxol relationship: part_of UPa:ULS00408 {cardinality="1", order="2"} ! taxol from baccatin III relationship: part_of UPa:ULS00408 ! taxol from baccatin III [Term] id: UPa:UER00814 name: serotonin from L-tryptophan: step 2/2 namespace: enzymatic_reaction def: "1 5-hydroxy-L-tryptophan => 1 CO(2) + 1 serotonin." [] xref: EC:4.1.1.28 xref: GO:0004058 "molecular_function:aromatic-L-amino-acid decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00643 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-hydroxy-L-tryptophan relationship: has_input_compound UPa:UPC00643 ! 5-hydroxy-L-tryptophan relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00780 {cardinality="1", is_alternate="False", is_primary="True"} ! serotonin relationship: has_output_compound UPa:UPC00780 ! serotonin relationship: part_of UPa:ULS00398 {cardinality="1", order="2"} ! serotonin from L-tryptophan relationship: part_of UPa:ULS00398 ! serotonin from L-tryptophan [Term] id: UPa:UER00815 name: melatonin from serotonin: step 1/2 namespace: enzymatic_reaction def: "1 acetyl-CoA + 1 serotonin => 1 CoA + 1 N-acetylserotonin." [] xref: EC:2.3.1.87 xref: GO:0004059 "molecular_function:aralkylamine N-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00780 ! serotonin relationship: has_input_compound UPa:UPC00780 {cardinality="1", is_alternate="False", is_primary="True"} ! serotonin relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00978 ! N-acetylserotonin relationship: has_output_compound UPa:UPC00978 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetylserotonin relationship: part_of UPa:ULS00409 {cardinality="1", order="1"} ! melatonin from serotonin relationship: part_of UPa:ULS00409 ! melatonin from serotonin [Term] id: UPa:UER00816 name: melatonin from serotonin: step 2/2 namespace: enzymatic_reaction def: "1 N-acetylserotonin + 1 S-adenosyl-L-methionine => 1 S-adenosyl-L-homocysteine + 1 melatonin." [] xref: EC:2.1.1.4 xref: GO:0017096 "molecular_function:acetylserotonin O-methyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00978 ! N-acetylserotonin relationship: has_input_compound UPa:UPC00978 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetylserotonin relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC01598 {cardinality="1", is_alternate="False", is_primary="True"} ! melatonin relationship: has_output_compound UPa:UPC01598 ! melatonin relationship: part_of UPa:ULS00409 {cardinality="1", order="2"} ! melatonin from serotonin relationship: part_of UPa:ULS00409 ! melatonin from serotonin [Term] id: UPa:UER00817 name: 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 3/3 namespace: enzymatic_reaction def: "1 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate => 1 10-deacetyl-2-debenzoylbaccatin III." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC11898 {cardinality="1", is_alternate="False", is_primary="True"} ! 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate relationship: has_input_compound UPa:UPC11898 ! 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate relationship: has_output_compound UPa:UPC11899 {cardinality="1", is_alternate="False", is_primary="True"} ! 10-deacetyl-2-debenzoylbaccatin III relationship: has_output_compound UPa:UPC11899 ! 10-deacetyl-2-debenzoylbaccatin III relationship: part_of UPa:ULS00406 {cardinality="1", order="3"} ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol relationship: part_of UPa:ULS00406 ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol [Term] id: UPa:UER00818 name: 7,8-dihydrofolate from folate: step 1/1 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 folate => 1 7,8-dihydrofolate + 1 NADP(+)." [] xref: EC:1.5.1 xref: GO:0004486 "molecular_function:methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity" xref: GO:0004753 "molecular_function:saccharopine dehydrogenase activity" xref: GO:0016646 "molecular_function:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor" xref: GO:0018529 "molecular_function:nitrilotriacetate monooxygenase activity" xref: GO:0044684 "molecular_function:dihydromethanopterin reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00504 ! folate relationship: has_input_compound UPa:UPC00504 {cardinality="1", is_alternate="False", is_primary="True"} ! folate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00415 ! 7,8-dihydrofolate relationship: has_output_compound UPa:UPC00415 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydrofolate relationship: part_of UPa:ULS00412 {cardinality="1", order="1"} ! 7,8-dihydrofolate from folate relationship: part_of UPa:ULS00412 ! 7,8-dihydrofolate from folate [Term] id: UPa:UER00819 name: tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3 namespace: enzymatic_reaction def: "1 7,8-dihydroneopterin triphosphate => 1 6-pyruvoyl-tetrahydropterin + 1 triphosphate." [] xref: EC:4.2.3.12 xref: GO:0003874 "molecular_function:6-pyruvoyltetrahydropterin synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04895 ! 7,8-dihydroneopterin triphosphate relationship: has_input_compound UPa:UPC04895 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC00536 {cardinality="1", is_alternate="False", is_primary="False"} ! triphosphate relationship: has_output_compound UPa:UPC00536 ! triphosphate relationship: has_output_compound UPa:UPC03684 ! 6-pyruvoyl-tetrahydropterin relationship: has_output_compound UPa:UPC03684 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-pyruvoyl-tetrahydropterin relationship: part_of UPa:ULS00413 {cardinality="1", order="1"} ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate relationship: part_of UPa:ULS00413 ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate [Term] id: UPa:UER00820 name: tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 2/3 namespace: enzymatic_reaction def: "1 6-pyruvoyl-tetrahydropterin + 1 H(+) + 1 NADPH => 1 6-lactoyl-5,6,7,8-tetrahydropterin + 1 NADP(+)." [] xref: EC:1.1.1.220 xref: GO:0047028 "molecular_function:6-pyruvoyltetrahydropterin 2'-reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC03684 ! 6-pyruvoyl-tetrahydropterin relationship: has_input_compound UPa:UPC03684 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-pyruvoyl-tetrahydropterin relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC04244 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-lactoyl-5,6,7,8-tetrahydropterin relationship: has_output_compound UPa:UPC04244 ! 6-lactoyl-5,6,7,8-tetrahydropterin relationship: part_of UPa:ULS00413 ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate relationship: part_of UPa:ULS00413 {cardinality="1", order="2"} ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate [Term] id: UPa:UER00821 name: tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 3/3 namespace: enzymatic_reaction def: "1 6-lactoyl-5,6,7,8-tetrahydropterin + 1 H(+) + 1 NADPH => 1 NADP(+) + 1 tetrahydrobiopterin." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC04244 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-lactoyl-5,6,7,8-tetrahydropterin relationship: has_input_compound UPa:UPC04244 ! 6-lactoyl-5,6,7,8-tetrahydropterin relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00272 {cardinality="1", is_alternate="False", is_primary="True"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: part_of UPa:ULS00413 ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate relationship: part_of UPa:ULS00413 {cardinality="1", order="3"} ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate [Term] id: UPa:UER00822 name: tetrahydrobiopterin from biopterin: step 1/1 namespace: enzymatic_reaction def: "2 H(+) + 2 NADPH + 1 biopterin => 2 NADP(+) + 1 tetrahydrobiopterin." [] xref: EC:1.5.1.33 xref: GO:0047040 "molecular_function:pteridine reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC06313 {cardinality="1", is_alternate="False", is_primary="True"} ! biopterin relationship: has_input_compound UPa:UPC06313 ! biopterin relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00272 {cardinality="1", is_alternate="False", is_primary="True"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: part_of UPa:ULS00414 ! tetrahydrobiopterin from biopterin relationship: part_of UPa:ULS00414 {cardinality="1", order="1"} ! tetrahydrobiopterin from biopterin [Term] id: UPa:UER00823 name: 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5 namespace: enzymatic_reaction def: "n H(2)O + 1 pectin => n methanol + 1 pectate." [] xref: EC:3.1.1.11 xref: GO:0030599 "molecular_function:pectinesterase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00714 ! pectin relationship: has_input_compound UPa:UPC00714 {cardinality="1", is_alternate="False", is_primary="True"} ! pectin relationship: has_output_compound UPa:UPC00132 ! methanol relationship: has_output_compound UPa:UPC00132 {cardinality="1", is_alternate="False", is_primary="False"} ! methanol relationship: has_output_compound UPa:UPC00470 {cardinality="1", is_alternate="False", is_primary="True"} ! pectate relationship: has_output_compound UPa:UPC00470 ! pectate relationship: part_of UPa:ULS00415 ! 2-dehydro-3-deoxy-D-gluconate from pectin relationship: part_of UPa:ULS00415 {cardinality="1", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin [Term] id: UPa:UER00824 name: 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5 namespace: enzymatic_reaction def: "1 pectate => 1 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid + 1 pectate(n-2)." [] xref: EC:4.2.2.2 xref: GO:0030570 "molecular_function:pectate lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00470 {cardinality="1", is_alternate="False", is_primary="True"} ! pectate relationship: has_input_compound UPa:UPC00470 ! pectate relationship: has_output_compound UPa:UPC06118 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid relationship: has_output_compound UPa:UPC06118 ! 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid relationship: has_output_compound UPa:UPX00024 ! pectate(n-2) relationship: has_output_compound UPa:UPX00024 {cardinality="1", is_alternate="False", is_primary="False"} ! pectate(n-2) relationship: part_of UPa:ULS00415 ! 2-dehydro-3-deoxy-D-gluconate from pectin relationship: part_of UPa:ULS00415 {cardinality="1", order="2"} ! 2-dehydro-3-deoxy-D-gluconate from pectin [Term] id: UPa:UER00825 name: 2-dehydro-3-deoxy-D-gluconate from pectin: step 3/5 namespace: enzymatic_reaction def: "1 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid => 2 5-dehydro-4-deoxy-D-glucuronic acid." [] xref: EC:4.2.2.6 xref: GO:0047487 "molecular_function:oligogalacturonide lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC06118 ! 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid relationship: has_input_compound UPa:UPC06118 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid relationship: has_output_compound UPa:UPC04053 ! 5-dehydro-4-deoxy-D-glucuronic acid relationship: has_output_compound UPa:UPC04053 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-dehydro-4-deoxy-D-glucuronic acid relationship: part_of UPa:ULS00415 ! 2-dehydro-3-deoxy-D-gluconate from pectin relationship: part_of UPa:ULS00415 {cardinality="1", order="3"} ! 2-dehydro-3-deoxy-D-gluconate from pectin [Term] id: UPa:UER00826 name: 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5 namespace: enzymatic_reaction def: "1 5-dehydro-4-deoxy-D-glucuronic acid => 1 3-deoxy-D-glycero-hexo-2,5-diulosonate." [] xref: EC:5.3.1.17 xref: GO:0008697 "molecular_function:4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04053 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-dehydro-4-deoxy-D-glucuronic acid relationship: has_input_compound UPa:UPC04053 ! 5-dehydro-4-deoxy-D-glucuronic acid relationship: has_output_compound UPa:UPC04349 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-deoxy-D-glycero-hexo-2,5-diulosonate relationship: has_output_compound UPa:UPC04349 ! 3-deoxy-D-glycero-hexo-2,5-diulosonate relationship: part_of UPa:ULS00415 ! 2-dehydro-3-deoxy-D-gluconate from pectin relationship: part_of UPa:ULS00415 {cardinality="1", order="4"} ! 2-dehydro-3-deoxy-D-gluconate from pectin [Term] id: UPa:UER00827 name: 2-dehydro-3-deoxy-D-gluconate from pectin: step 5/5 namespace: enzymatic_reaction def: "1 3-deoxy-D-glycero-hexo-2,5-diulosonate + 1 H(+) + 1 NADH => 1 2-dehydro-3-deoxy-D-gluconate + 1 NAD(+)." [] xref: EC:1.1.1.127 xref: GO:0047001 "molecular_function:2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC04349 ! 3-deoxy-D-glycero-hexo-2,5-diulosonate relationship: has_input_compound UPa:UPC04349 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-deoxy-D-glycero-hexo-2,5-diulosonate relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00204 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydro-3-deoxy-D-gluconate relationship: has_output_compound UPa:UPC00204 ! 2-dehydro-3-deoxy-D-gluconate relationship: part_of UPa:ULS00415 ! 2-dehydro-3-deoxy-D-gluconate from pectin relationship: part_of UPa:ULS00415 {cardinality="1", order="5"} ! 2-dehydro-3-deoxy-D-gluconate from pectin [Term] id: UPa:UER00828 name: D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 1/2 namespace: enzymatic_reaction def: "1 2-dehydro-3-deoxy-D-gluconate + 1 ATP => 1 2-dehydro-3-deoxy-6-phospho-D-gluconic acid + 1 ADP." [] xref: EC:2.7.1.45 xref: GO:0008673 "molecular_function:2-dehydro-3-deoxygluconokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00204 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydro-3-deoxy-D-gluconate relationship: has_input_compound UPa:UPC00204 ! 2-dehydro-3-deoxy-D-gluconate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC04442 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid relationship: has_output_compound UPa:UPC04442 ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid relationship: part_of UPa:ULS00416 ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate relationship: part_of UPa:ULS00416 {cardinality="1", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate [Term] id: UPa:UER00829 name: D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 2/2 namespace: enzymatic_reaction def: "1 2-dehydro-3-deoxy-6-phospho-D-gluconic acid => 1 D-glyceraldehyde 3-phosphate + 1 pyruvate." [] xref: EC:4.1.2.14 xref: GO:0008675 "molecular_function:2-dehydro-3-deoxy-phosphogluconate aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04442 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid relationship: has_input_compound UPa:UPC04442 ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00416 ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate relationship: part_of UPa:ULS00416 {cardinality="1", order="2"} ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate [Term] id: UPa:UER00830 name: 3-phospho-D-glycerate from glycolate: step 1/4 namespace: enzymatic_reaction def: "1 acceptor + 1 glycolate => 1 glyoxylate + 1 reduced acceptor." [] xref: EC:1.1.3.15 xref: EC:1.1.99.14 xref: GO:0003973 "molecular_function:(S)-2-hydroxy-acid oxidase activity" xref: GO:0019154 "molecular_function:glycolate dehydrogenase activity" xref: GO:0052852 "molecular_function:very-long-chain-(S)-2-hydroxy-acid oxidase activity" xref: GO:0052853 "molecular_function:long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity" xref: GO:0052854 "molecular_function:medium-chain-(S)-2-hydroxy-acid oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_input_compound UPa:UPC00160 {cardinality="1", is_alternate="False", is_primary="True"} ! glycolate relationship: has_input_compound UPa:UPC00160 ! glycolate relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_output_compound UPa:UPC00048 ! glyoxylate relationship: has_output_compound UPa:UPC00048 {cardinality="1", is_alternate="False", is_primary="True"} ! glyoxylate relationship: part_of UPa:ULS00417 {cardinality="1", order="1"} ! 3-phospho-D-glycerate from glycolate relationship: part_of UPa:ULS00417 ! 3-phospho-D-glycerate from glycolate [Term] id: UPa:UER00831 name: 3-phospho-D-glycerate from glycolate: step 2/4 namespace: enzymatic_reaction def: "2 glyoxylate => 1 2-hydroxy-3-oxopropanoate + 1 CO(2)." [] xref: EC:4.1.1.47 xref: GO:0009028 "molecular_function:tartronate-semialdehyde synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00048 {cardinality="1", is_alternate="False", is_primary="True"} ! glyoxylate relationship: has_input_compound UPa:UPC00048 ! glyoxylate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC01146 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxopropanoate relationship: has_output_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate relationship: part_of UPa:ULS00417 {cardinality="1", order="2"} ! 3-phospho-D-glycerate from glycolate relationship: part_of UPa:ULS00417 ! 3-phospho-D-glycerate from glycolate [Term] id: UPa:UER00832 name: 3-phospho-D-glycerate from glycolate: step 3/4 namespace: enzymatic_reaction def: "2-hydroxy-3-oxopropanoate + H(+) + [NADH or NADPH] => D-glycerate + [NAD(+) or NADP(+)]." [] xref: EC:1.1.1.60 xref: GO:0008679 "molecular_function:2-hydroxy-3-oxopropionate reductase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00973 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00974 ! None relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate relationship: has_input_compound UPa:UPC01146 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxopropanoate relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: has_output_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: part_of UPa:ULS00417 {cardinality="1", order="3"} ! 3-phospho-D-glycerate from glycolate relationship: part_of UPa:ULS00417 ! 3-phospho-D-glycerate from glycolate [Term] id: UPa:UER00833 name: 3-phospho-D-glycerate from glycolate: step 4/4 namespace: enzymatic_reaction def: "1 ATP + 1 D-glycerate => 1 3-phospho-D-glycerate + 1 ADP." [] xref: EC:2.7.1.31 xref: GO:0008887 "molecular_function:glycerate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00197 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: part_of UPa:ULS00417 {cardinality="1", order="4"} ! 3-phospho-D-glycerate from glycolate relationship: part_of UPa:ULS00417 ! 3-phospho-D-glycerate from glycolate [Term] id: UPa:UER00834 name: glycolate from 2-phosphoglycolate: step 1/1 namespace: enzymatic_reaction def: "1 2-phosphoglycolate + 1 H(2)O => 1 glycolate + 1 phosphate." [] xref: EC:3.1.3.18 xref: GO:0008967 "molecular_function:phosphoglycolate phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00988 ! 2-phosphoglycolate relationship: has_input_compound UPa:UPC00988 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-phosphoglycolate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00160 {cardinality="1", is_alternate="False", is_primary="True"} ! glycolate relationship: has_output_compound UPa:UPC00160 ! glycolate relationship: part_of UPa:ULS00418 {cardinality="1", order="1"} ! glycolate from 2-phosphoglycolate relationship: part_of UPa:ULS00418 ! glycolate from 2-phosphoglycolate [Term] id: UPa:UER00835 name: glutaryl-CoA from L-lysine: step 1/6 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 H(+) + 1 L-lysine + 1 NADPH => 1 H(2)O + 1 NADP(+) + 1 saccharopine." [] xref: EC:1.5.1.8 xref: GO:0047130 "molecular_function:saccharopine dehydrogenase (NADP+, L-lysine-forming) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00047 ! L-lysine relationship: has_input_compound UPa:UPC00047 {cardinality="1", is_alternate="False", is_primary="True"} ! L-lysine relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00449 ! saccharopine relationship: has_output_compound UPa:UPC00449 {cardinality="1", is_alternate="False", is_primary="True"} ! saccharopine relationship: part_of UPa:ULS00419 {cardinality="1", order="1"} ! glutaryl-CoA from L-lysine relationship: part_of UPa:ULS00419 ! glutaryl-CoA from L-lysine [Term] id: UPa:UER00836 name: glutaryl-CoA from L-lysine: step 2/6 namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 saccharopine => 1 H(+) + 1 L-2-aminoadipate 6-semialdahyde + 1 L-glutamate + 1 NADH." [] xref: EC:1.5.1.9 xref: GO:0047131 "molecular_function:saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00449 {cardinality="1", is_alternate="False", is_primary="True"} ! saccharopine relationship: has_input_compound UPa:UPC00449 ! saccharopine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC04076 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: part_of UPa:ULS00419 {cardinality="1", order="2"} ! glutaryl-CoA from L-lysine relationship: part_of UPa:ULS00419 ! glutaryl-CoA from L-lysine [Term] id: UPa:UER00837 name: glutaryl-CoA from L-lysine: step 3/6 namespace: enzymatic_reaction def: "H(2)O + L-2-aminoadipate 6-semialdahyde + [NAD(+) or NADP(+)] => H(+) + L-alpha-aminoadipate + [NADH or NADPH]." [] xref: EC:1.2.1.31 xref: GO:0004043 "molecular_function:L-aminoadipate-semialdehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00985 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00986 ! None relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC04076 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-aminoadipate 6-semialdahyde relationship: has_input_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alpha-aminoadipate relationship: part_of UPa:ULS00419 {cardinality="1", order="3"} ! glutaryl-CoA from L-lysine relationship: part_of UPa:ULS00419 ! glutaryl-CoA from L-lysine [Term] id: UPa:UER00838 name: glutaryl-CoA from L-lysine: step 4/6 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 L-alpha-aminoadipate => 1 2-oxoadipate + 1 L-glutamate." [] xref: EC:2.6.1.39 xref: GO:0047536 "molecular_function:2-aminoadipate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00322 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoadipate relationship: has_output_compound UPa:UPC00322 ! 2-oxoadipate relationship: part_of UPa:ULS00419 {cardinality="1", order="4"} ! glutaryl-CoA from L-lysine relationship: part_of UPa:ULS00419 ! glutaryl-CoA from L-lysine [Term] id: UPa:UER00839 name: glutaryl-CoA from L-lysine: step 5/6 namespace: enzymatic_reaction def: "1 2-oxoadipate + 1 Enzyme N6-(lipoyl)lysine => 1 CO(2) + 1 S(8)-glutaryldihydrolipoamide." [] xref: EC:1.2.4.2 xref: GO:0004591 "molecular_function:oxoglutarate dehydrogenase (succinyl-transferring) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00322 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoadipate relationship: has_input_compound UPa:UPC00322 ! 2-oxoadipate relationship: has_input_compound UPa:UPC15972 {cardinality="1", is_alternate="False", is_primary="False"} ! Enzyme N6-(lipoyl)lysine relationship: has_input_compound UPa:UPC15972 ! Enzyme N6-(lipoyl)lysine relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC06157 ! S(8)-glutaryldihydrolipoamide relationship: has_output_compound UPa:UPC06157 {cardinality="1", is_alternate="False", is_primary="True"} ! S(8)-glutaryldihydrolipoamide relationship: part_of UPa:ULS00419 {cardinality="1", order="5"} ! glutaryl-CoA from L-lysine relationship: part_of UPa:ULS00419 ! glutaryl-CoA from L-lysine [Term] id: UPa:UER00840 name: glutaryl-CoA from L-lysine: step 6/6 namespace: enzymatic_reaction def: "1 CoA + 1 S(8)-glutaryldihydrolipoamide => 1 Enzyme N6-(dihydrolipoyl)lysine + 1 glutaryl-CoA." [] xref: EC:2.3.1.61 xref: GO:0004149 "molecular_function:dihydrolipoyllysine-residue succinyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC06157 {cardinality="1", is_alternate="False", is_primary="True"} ! S(8)-glutaryldihydrolipoamide relationship: has_input_compound UPa:UPC06157 ! S(8)-glutaryldihydrolipoamide relationship: has_output_compound UPa:UPC00527 {cardinality="1", is_alternate="False", is_primary="True"} ! glutaryl-CoA relationship: has_output_compound UPa:UPC00527 ! glutaryl-CoA relationship: has_output_compound UPa:UPC15973 ! Enzyme N6-(dihydrolipoyl)lysine relationship: has_output_compound UPa:UPC15973 {cardinality="1", is_alternate="False", is_primary="False"} ! Enzyme N6-(dihydrolipoyl)lysine relationship: part_of UPa:ULS00419 ! glutaryl-CoA from L-lysine relationship: part_of UPa:ULS00419 {cardinality="1", order="6"} ! glutaryl-CoA from L-lysine [Term] id: UPa:UER00841 name: glutarate from L-lysine: step 1/6 namespace: enzymatic_reaction def: "1 L-lysine + 1 acetyl phosphate => 1 N(6)-acetyl-L-lysine + 1 phosphate." [] xref: EC:2.3.1.32 xref: GO:0004468 "molecular_function:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00047 {cardinality="1", is_alternate="False", is_primary="True"} ! L-lysine relationship: has_input_compound UPa:UPC00047 ! L-lysine relationship: has_input_compound UPa:UPC00227 ! acetyl phosphate relationship: has_input_compound UPa:UPC00227 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC02727 {cardinality="1", is_alternate="False", is_primary="True"} ! N(6)-acetyl-L-lysine relationship: has_output_compound UPa:UPC02727 ! N(6)-acetyl-L-lysine relationship: part_of UPa:ULS00420 ! glutarate from L-lysine relationship: part_of UPa:ULS00420 {cardinality="1", order="1"} ! glutarate from L-lysine [Term] id: UPa:UER00842 name: glutarate from L-lysine: step 2/6 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 N(6)-acetyl-L-lysine => 1 6-acetamido-2-oxohexanoate + 1 L-glutamate." [] xref: EC:2.6.1 xref: GO:0008483 "molecular_function:transaminase activity" xref: GO:0010326 "molecular_function:methionine-oxo-acid transaminase activity" xref: GO:0018719 "molecular_function:6-aminohexanoate transaminase activity" xref: GO:0043746 "molecular_function:N2-acetyl-L-lysine aminotransferase activity" xref: GO:0043760 "molecular_function:acetyldiaminopimelate aminotransferase activity" xref: GO:0043840 "molecular_function:branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" xref: GO:0043911 "molecular_function:D-lysine transaminase activity" xref: GO:0046571 "molecular_function:aspartate-2-keto-4-methylthiobutyrate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC02727 {cardinality="1", is_alternate="False", is_primary="True"} ! N(6)-acetyl-L-lysine relationship: has_input_compound UPa:UPC02727 ! N(6)-acetyl-L-lysine relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC05548 ! 6-acetamido-2-oxohexanoate relationship: has_output_compound UPa:UPC05548 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-acetamido-2-oxohexanoate relationship: part_of UPa:ULS00420 ! glutarate from L-lysine relationship: part_of UPa:ULS00420 {cardinality="1", order="2"} ! glutarate from L-lysine [Term] id: UPa:UER00843 name: glutarate from L-lysine: step 3/6 namespace: enzymatic_reaction def: "1 6-acetamido-2-oxohexanoate + 1 H(2)O + 1 NAD(+) => 1 5-acetamidopentanoate + 1 CO(2) + 1 H(+) + 1 NADH." [] xref: EC:1.1.1 xref: GO:0000252 "molecular_function:C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity" xref: GO:0004033 "molecular_function:aldo-keto reductase (NADP) activity" xref: GO:0004448 "molecular_function:isocitrate dehydrogenase activity" xref: GO:0004495 "molecular_function:mevaldate reductase activity" xref: GO:0008875 "molecular_function:gluconate dehydrogenase activity" xref: GO:0016229 "molecular_function:steroid dehydrogenase activity" xref: GO:0016616 "molecular_function:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" xref: GO:0018451 "molecular_function:epoxide dehydrogenase activity" xref: GO:0018452 "molecular_function:5-exo-hydroxycamphor dehydrogenase activity" xref: GO:0018453 "molecular_function:2-hydroxytetrahydrofuran dehydrogenase activity" xref: GO:0019152 "molecular_function:acetoin dehydrogenase activity" xref: GO:0032442 "molecular_function:phenylcoumaran benzylic ether reductase activity" xref: GO:0032866 "molecular_function:D-xylose:NADP reductase activity" xref: GO:0032867 "molecular_function:L-arabinose:NADP reductase activity" xref: GO:0033709 "molecular_function:D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity" xref: GO:0033764 "molecular_function:steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" xref: GO:0033765 "molecular_function:steroid dehydrogenase activity, acting on the CH-CH group of donors" xref: GO:0034831 "molecular_function:(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity" xref: GO:0034840 "molecular_function:3-hydroxymenthone dehydrogenase activity" xref: GO:0035380 "molecular_function:very long-chain-3-hydroxyacyl-CoA dehydrogenase activity" xref: GO:0035410 "molecular_function:dihydrotestosterone 17-beta-dehydrogenase activity" xref: GO:0043713 "molecular_function:(R)-2-hydroxyisocaproate dehydrogenase activity" xref: GO:0044103 "molecular_function:L-arabinose 1-dehydrogenase (NADP+) activity" xref: GO:0044105 "molecular_function:L-xylulose reductase (NAD+) activity" xref: GO:0048258 "molecular_function:3-ketoglucose-reductase activity" xref: GO:0051990 "molecular_function:(R)-2-hydroxyglutarate dehydrogenase activity" xref: GO:0052677 "molecular_function:D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC05548 ! 6-acetamido-2-oxohexanoate relationship: has_input_compound UPa:UPC05548 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-acetamido-2-oxohexanoate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC03087 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-acetamidopentanoate relationship: has_output_compound UPa:UPC03087 ! 5-acetamidopentanoate relationship: part_of UPa:ULS00420 ! glutarate from L-lysine relationship: part_of UPa:ULS00420 {cardinality="1", order="3"} ! glutarate from L-lysine [Term] id: UPa:UER00844 name: glutarate from L-lysine: step 4/6 namespace: enzymatic_reaction def: "1 5-acetamidopentanoate + 1 H(2)O => 1 5-aminopentanoate + 1 acetate." [] xref: EC:3.5.1.63 xref: GO:0047573 "molecular_function:4-acetamidobutyrate deacetylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC03087 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-acetamidopentanoate relationship: has_input_compound UPa:UPC03087 ! 5-acetamidopentanoate relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00431 ! 5-aminopentanoate relationship: has_output_compound UPa:UPC00431 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-aminopentanoate relationship: part_of UPa:ULS00420 ! glutarate from L-lysine relationship: part_of UPa:ULS00420 {cardinality="1", order="4"} ! glutarate from L-lysine [Term] id: UPa:UER00845 name: glutarate from L-lysine: step 5/6 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 5-aminopentanoate => 1 5-oxopentanoate + 1 L-glutamate." [] xref: EC:2.6.1.48 xref: GO:0047589 "molecular_function:5-aminovalerate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00431 ! 5-aminopentanoate relationship: has_input_compound UPa:UPC00431 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-aminopentanoate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC03273 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-oxopentanoate relationship: has_output_compound UPa:UPC03273 ! 5-oxopentanoate relationship: part_of UPa:ULS00420 ! glutarate from L-lysine relationship: part_of UPa:ULS00420 {cardinality="1", order="5"} ! glutarate from L-lysine [Term] id: UPa:UER00846 name: glutarate from L-lysine: step 6/6 namespace: enzymatic_reaction def: "1 5-oxopentanoate + 1 H(2)O + 1 NAD(+) => 1 H(+) + 1 NADH + 1 glutarate." [] xref: EC:1.2.1.20 xref: GO:0047949 "molecular_function:glutarate-semialdehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC03273 ! 5-oxopentanoate relationship: has_input_compound UPa:UPC03273 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-oxopentanoate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00489 {cardinality="1", is_alternate="False", is_primary="True"} ! glutarate relationship: has_output_compound UPa:UPC00489 ! glutarate relationship: part_of UPa:ULS00420 ! glutarate from L-lysine relationship: part_of UPa:ULS00420 {cardinality="1", order="6"} ! glutarate from L-lysine [Term] id: UPa:UER00847 name: 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 1/5 namespace: enzymatic_reaction def: "1 indoleglycerol phosphate => 1 D-glyceraldehyde 3-phosphate + 1 indole." [] xref: EC:4.1.2.8 xref: GO:0033984 "molecular_function:indole-3-glycerol-phosphate lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03506 {cardinality="1", is_alternate="False", is_primary="True"} ! indoleglycerol phosphate relationship: has_input_compound UPa:UPC03506 ! indoleglycerol phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="False"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00463 {cardinality="1", is_alternate="False", is_primary="True"} ! indole relationship: has_output_compound UPa:UPC00463 ! indole relationship: part_of UPa:ULS00421 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate relationship: part_of UPa:ULS00421 {cardinality="1", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate [Term] id: UPa:UER00848 name: 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 2/5 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 O(2) + 1 indole => 1 H(2)O + 1 NADP(+) + 1 indolin-2-one." [] xref: EC:1.14.13.137 xref: GO:0036190 "molecular_function:indole-2-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00463 ! indole relationship: has_input_compound UPa:UPC00463 {cardinality="1", is_alternate="False", is_primary="True"} ! indole relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC12312 ! indolin-2-one relationship: has_output_compound UPa:UPC12312 {cardinality="1", is_alternate="False", is_primary="True"} ! indolin-2-one relationship: part_of UPa:ULS00421 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate relationship: part_of UPa:ULS00421 {cardinality="1", order="2"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate [Term] id: UPa:UER00849 name: 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 3/5 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 O(2) + 1 indolin-2-one => 1 3-hydroxyindolin-2-one + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.138 xref: GO:0036191 "molecular_function:indolin-2-one monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC12312 {cardinality="1", is_alternate="False", is_primary="True"} ! indolin-2-one relationship: has_input_compound UPa:UPC12312 ! indolin-2-one relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC11130 ! 3-hydroxyindolin-2-one relationship: has_output_compound UPa:UPC11130 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxyindolin-2-one relationship: part_of UPa:ULS00421 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate relationship: part_of UPa:ULS00421 {cardinality="1", order="3"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate [Term] id: UPa:UER00850 name: 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 4/5 namespace: enzymatic_reaction def: "1 3-hydroxyindolin-2-one + 1 H(+) + 1 NADPH + 1 O(2) => 1 2-hydroxy-1,4-benzoxazin-3-one + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.139 xref: GO:0036192 "molecular_function:3-hydroxyindolin-2-one monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC11130 ! 3-hydroxyindolin-2-one relationship: has_input_compound UPa:UPC11130 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxyindolin-2-one relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC15769 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-1,4-benzoxazin-3-one relationship: has_output_compound UPa:UPC15769 ! 2-hydroxy-1,4-benzoxazin-3-one relationship: part_of UPa:ULS00421 {cardinality="1", order="4"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate relationship: part_of UPa:ULS00421 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate [Term] id: UPa:UER00851 name: 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 5/5 namespace: enzymatic_reaction def: "1 2-hydroxy-1,4-benzoxazin-3-one + 1 H(+) + 1 NADPH + 1 O(2) => 1 2,4-dihydroxy-1,4-benzoxazin-3-one + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14 xref: GO:0016705 "molecular_function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" xref: GO:0018585 "molecular_function:fluorene oxygenase activity" xref: GO:0018586 "molecular_function:mono-butyltin dioxygenase activity" xref: GO:0018588 "molecular_function:tri-n-butyltin dioxygenase activity" xref: GO:0018589 "molecular_function:di-n-butyltin dioxygenase activity" xref: GO:0018590 "molecular_function:methylsilanetriol hydroxylase activity" xref: GO:0018591 "molecular_function:methyl tertiary butyl ether 3-monooxygenase activity" xref: GO:0018592 "molecular_function:4-nitrocatechol 4-monooxygenase activity" xref: GO:0018593 "molecular_function:4-chlorophenoxyacetate monooxygenase activity" xref: GO:0018594 "molecular_function:tert-butanol 2-monooxygenase activity" xref: GO:0018595 "molecular_function:alpha-pinene monooxygenase activity" xref: GO:0018596 "molecular_function:dimethylsilanediol hydroxylase activity" xref: GO:0018597 "molecular_function:ammonia monooxygenase activity" xref: GO:0018598 "molecular_function:hydroxymethylsilanetriol oxidase activity" xref: GO:0018599 "molecular_function:2-hydroxyisobutyrate 3-monooxygenase activity" xref: GO:0018600 "molecular_function:alpha-pinene dehydrogenase activity" xref: GO:0034559 "molecular_function:bisphenol A hydroxylase B activity" xref: GO:0034562 "molecular_function:2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity" xref: GO:0034786 "molecular_function:9-fluorenone-3,4-dioxygenase activity" xref: GO:0034816 "molecular_function:anthracene 9,10-dioxygenase activity" xref: GO:0034857 "molecular_function:2-(methylthio)benzothiazole monooxygenase activity" xref: GO:0034858 "molecular_function:2-hydroxybenzothiazole monooxygenase activity" xref: GO:0034859 "molecular_function:benzothiazole monooxygenase activity" xref: GO:0034862 "molecular_function:2,6-dihydroxybenzothiazole monooxygenase activity" xref: GO:0034870 "molecular_function:pinacolone 5-monooxygenase activity" xref: GO:0034873 "molecular_function:thioacetamide S-oxygenase activity" xref: GO:0034874 "molecular_function:thioacetamide S-oxide S-oxygenase activity" xref: GO:0034888 "molecular_function:endosulfan monooxygenase I activity" xref: GO:0034893 "molecular_function:N-nitrodimethylamine hydroxylase activity" xref: GO:0034897 "molecular_function:4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity" xref: GO:0034903 "molecular_function:endosulfan ether monooxygenase activity" xref: GO:0034925 "molecular_function:pyrene 4,5-monooxygenase activity" xref: GO:0034927 "molecular_function:pyrene 1,2-monooxygenase activity" xref: GO:0034928 "molecular_function:1-hydroxypyrene 6,7-monooxygenase activity" xref: GO:0034929 "molecular_function:1-hydroxypyrene 7,8-monooxygenase activity" xref: GO:0034950 "molecular_function:phenylboronic acid monooxygenase activity" xref: GO:0043823 "molecular_function:spheroidene monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC15769 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-1,4-benzoxazin-3-one relationship: has_input_compound UPa:UPC15769 ! 2-hydroxy-1,4-benzoxazin-3-one relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC15770 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one relationship: has_output_compound UPa:UPC15770 ! 2,4-dihydroxy-1,4-benzoxazin-3-one relationship: part_of UPa:ULS00421 {cardinality="1", order="5"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate relationship: part_of UPa:ULS00421 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate [Term] id: UPa:UER00852 name: benzoate from (R)-mandelate: step 1/4 namespace: enzymatic_reaction def: "1 (R)-mandelate => 1 (S)-mandelate." [] xref: EC:5.1.2.2 xref: GO:0018838 "molecular_function:mandelate racemase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01983 ! (R)-mandelate relationship: has_input_compound UPa:UPC01983 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-mandelate relationship: has_output_compound UPa:UPC01984 ! (S)-mandelate relationship: has_output_compound UPa:UPC01984 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-mandelate relationship: part_of UPa:ULS00422 {cardinality="1", order="1"} ! benzoate from (R)-mandelate relationship: part_of UPa:ULS00422 ! benzoate from (R)-mandelate [Term] id: UPa:UER00853 name: benzoate from (R)-mandelate: step 2/4 namespace: enzymatic_reaction def: "1 (S)-mandelate + 1 acceptor => 1 phenylglyoxylate + 1 reduced acceptor." [] xref: EC:1.1.99.31 xref: GO:0033720 "molecular_function:(S)-mandelate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC01984 ! (S)-mandelate relationship: has_input_compound UPa:UPC01984 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-mandelate relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_output_compound UPa:UPC02137 {cardinality="1", is_alternate="False", is_primary="True"} ! phenylglyoxylate relationship: has_output_compound UPa:UPC02137 ! phenylglyoxylate relationship: part_of UPa:ULS00422 {cardinality="1", order="2"} ! benzoate from (R)-mandelate relationship: part_of UPa:ULS00422 ! benzoate from (R)-mandelate [Term] id: UPa:UER00854 name: benzoate from (R)-mandelate: step 3/4 namespace: enzymatic_reaction def: "1 phenylglyoxylate => 1 CO(2) + 1 benzaldehyde." [] xref: EC:4.1.1.7 xref: GO:0050695 "molecular_function:benzoylformate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC02137 ! phenylglyoxylate relationship: has_input_compound UPa:UPC02137 {cardinality="1", is_alternate="False", is_primary="True"} ! phenylglyoxylate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00261 {cardinality="1", is_alternate="False", is_primary="True"} ! benzaldehyde relationship: has_output_compound UPa:UPC00261 ! benzaldehyde relationship: part_of UPa:ULS00422 {cardinality="1", order="3"} ! benzoate from (R)-mandelate relationship: part_of UPa:ULS00422 ! benzoate from (R)-mandelate [Term] id: UPa:UER00855 name: benzoate from (R)-mandelate: step 4/4 namespace: enzymatic_reaction def: "H(2)O + benzaldehyde + [NAD(+) or NADP(+)] => H(+) + benzoate + [NADH or NADPH]." [] xref: EC:1.2.1.28 xref: EC:1.2.1.7 xref: GO:0018477 "molecular_function:benzaldehyde dehydrogenase (NADP+) activity" xref: GO:0018479 "molecular_function:benzaldehyde dehydrogenase (NAD+) activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00987 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00988 ! None relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00261 {cardinality="1", is_alternate="False", is_primary="True"} ! benzaldehyde relationship: has_input_compound UPa:UPC00261 ! benzaldehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00180 {cardinality="1", is_alternate="False", is_primary="True"} ! benzoate relationship: has_output_compound UPa:UPC00180 ! benzoate relationship: part_of UPa:ULS00422 {cardinality="1", order="4"} ! benzoate from (R)-mandelate relationship: part_of UPa:ULS00422 ! benzoate from (R)-mandelate [Term] id: UPa:UER00856 name: tetrahydrobiopterin from dihydrobiopterin: step 1/1 namespace: enzymatic_reaction def: "H(+) + dihydrobiopterin + [NADH or NADPH] => tetrahydrobiopterin + [NAD(+) or NADP(+)]." [] xref: EC:1.5.1.34 xref: GO:0004155 "molecular_function:6,7-dihydropteridine reductase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00993 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00994 ! None relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00268 {cardinality="1", is_alternate="False", is_primary="True"} ! dihydrobiopterin relationship: has_input_compound UPa:UPC00268 ! dihydrobiopterin relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00272 {cardinality="1", is_alternate="False", is_primary="True"} ! tetrahydrobiopterin relationship: part_of UPa:ULS00423 {cardinality="1", order="1"} ! tetrahydrobiopterin from dihydrobiopterin relationship: part_of UPa:ULS00423 ! tetrahydrobiopterin from dihydrobiopterin [Term] id: UPa:UER00857 name: 4-methyl-2-oxopentanoate from L-leucine (aminotransferase route): step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 L-leucine => 1 4-methyl-2-oxopentanoate + 1 L-glutamate." [] xref: EC:2.6.1.42 xref: GO:0004084 "molecular_function:branched-chain-amino-acid transaminase activity" xref: GO:0052654 "molecular_function:L-leucine transaminase activity" xref: GO:0052655 "molecular_function:L-valine transaminase activity" xref: GO:0052656 "molecular_function:L-isoleucine transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00123 {cardinality="1", is_alternate="False", is_primary="True"} ! L-leucine relationship: has_input_compound UPa:UPC00123 ! L-leucine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00233 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate relationship: part_of UPa:ULS00424 {cardinality="1", order="1"} ! 4-methyl-2-oxopentanoate from L-leucine (aminotransferase route) relationship: part_of UPa:ULS00424 ! 4-methyl-2-oxopentanoate from L-leucine (aminotransferase route) [Term] id: UPa:UER00858 name: 4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route): step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-leucine + 1 NAD(+) => 1 4-methyl-2-oxopentanoate + 1 H(+) + 1 NADH + 1 NH(3)." [] xref: EC:1.4.1.9 xref: GO:0050049 "molecular_function:leucine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00123 {cardinality="1", is_alternate="False", is_primary="True"} ! L-leucine relationship: has_input_compound UPa:UPC00123 ! L-leucine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00233 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-2-oxopentanoate relationship: part_of UPa:ULS00425 {cardinality="1", order="1"} ! 4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route) relationship: part_of UPa:ULS00425 ! 4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route) [Term] id: UPa:UER00859 name: 3-isovaleryl-CoA from 4-methyl-2-oxopentanoate: step 1/1 namespace: enzymatic_reaction def: "1 4-methyl-2-oxopentanoate + 1 CoA + 1 NAD(+) => 1 3-isovaleryl-CoA + 1 CO(2) + 1 H(+) + 1 NADH." [] xref: EC:1.2.1.25 xref: GO:0047101 "molecular_function:2-oxoisovalerate dehydrogenase (acylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00233 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-2-oxopentanoate relationship: has_input_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC02939 ! 3-isovaleryl-CoA relationship: has_output_compound UPa:UPC02939 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-isovaleryl-CoA relationship: part_of UPa:ULS00426 {cardinality="1", order="1"} ! 3-isovaleryl-CoA from 4-methyl-2-oxopentanoate relationship: part_of UPa:ULS00426 ! 3-isovaleryl-CoA from 4-methyl-2-oxopentanoate [Term] id: UPa:UER00860 name: (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3 namespace: enzymatic_reaction def: "1 3-isovaleryl-CoA + 1 FAD => 1 3-methylcrotonyl-CoA + 1 FADH2." [] xref: EC:1.3.8.4 xref: GO:0008470 "molecular_function:isovaleryl-CoA dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00016 ! FAD relationship: has_input_compound UPa:UPC00016 {cardinality="1", is_alternate="False", is_primary="False"} ! FAD relationship: has_input_compound UPa:UPC02939 ! 3-isovaleryl-CoA relationship: has_input_compound UPa:UPC02939 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-isovaleryl-CoA relationship: has_output_compound UPa:UPC01352 {cardinality="1", is_alternate="False", is_primary="False"} ! FADH2 relationship: has_output_compound UPa:UPC01352 ! FADH2 relationship: has_output_compound UPa:UPC03069 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methylcrotonyl-CoA relationship: has_output_compound UPa:UPC03069 ! 3-methylcrotonyl-CoA relationship: part_of UPa:ULS00427 ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA relationship: part_of UPa:ULS00427 {cardinality="1", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA [Term] id: UPa:UER00861 name: (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3 namespace: enzymatic_reaction def: "1 3-methylcrotonyl-CoA + 1 ATP + 1 bicarbonate => 1 3-methylglutaconyl-CoA + 1 ADP + 1 phosphate." [] xref: EC:6.4.1.4 xref: GO:0004485 "molecular_function:methylcrotonoyl-CoA carboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_input_compound UPa:UPC00288 {cardinality="1", is_alternate="False", is_primary="False"} ! bicarbonate relationship: has_input_compound UPa:UPC03069 ! 3-methylcrotonyl-CoA relationship: has_input_compound UPa:UPC03069 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methylcrotonyl-CoA relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC03231 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methylglutaconyl-CoA relationship: has_output_compound UPa:UPC03231 ! 3-methylglutaconyl-CoA relationship: part_of UPa:ULS00427 ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA relationship: part_of UPa:ULS00427 {cardinality="1", order="2"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA [Term] id: UPa:UER00862 name: (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3 namespace: enzymatic_reaction def: "1 3-methylglutaconyl-CoA + 1 H(2)O => 1 (S)-3-hydroxy-3-methylglutaryl-CoA." [] xref: EC:4.2.1.18 xref: GO:0004490 "molecular_function:methylglutaconyl-CoA hydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC03231 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methylglutaconyl-CoA relationship: has_input_compound UPa:UPC03231 ! 3-methylglutaconyl-CoA relationship: has_output_compound UPa:UPC00356 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: part_of UPa:ULS00427 ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA relationship: part_of UPa:ULS00427 {cardinality="1", order="3"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA [Term] id: UPa:UER00863 name: acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1 namespace: enzymatic_reaction def: "1 (S)-3-hydroxy-3-methylglutaryl-CoA => 1 acetoacetate + 1 acetyl-CoA." [] xref: EC:4.1.3.4 xref: GO:0004419 "molecular_function:hydroxymethylglutaryl-CoA lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_input_compound UPa:UPC00356 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00164 {cardinality="1", is_alternate="False", is_primary="True"} ! acetoacetate relationship: has_output_compound UPa:UPC00164 ! acetoacetate relationship: part_of UPa:ULS00431 ! acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA relationship: part_of UPa:ULS00431 {cardinality="1", order="1"} ! acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA [Term] id: UPa:UER00864 name: (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 1/3 namespace: enzymatic_reaction def: "1 (4R)-limonene + 1 H(+) + 1 NADH + 1 O(2) => 1 (4R)-limonene 1,2-epoxide + 1 H(2)O + 1 NAD(+)." [] xref: EC:1.14.13.107 xref: GO:0018635 "molecular_function:(R)-limonene 1,2-monooxygenase activity" xref: GO:0052601 "molecular_function:(S)-limonene 1,2-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC06099 {cardinality="1", is_alternate="False", is_primary="True"} ! (4R)-limonene relationship: has_input_compound UPa:UPC06099 ! (4R)-limonene relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC07271 ! (4R)-limonene 1,2-epoxide relationship: has_output_compound UPa:UPC07271 {cardinality="1", is_alternate="False", is_primary="True"} ! (4R)-limonene 1,2-epoxide relationship: part_of UPa:ULS00428 ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene relationship: part_of UPa:ULS00428 {cardinality="1", order="1"} ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene [Term] id: UPa:UER00865 name: (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 2/3 namespace: enzymatic_reaction def: "1 (4R)-limonene 1,2-epoxide + 1 H(2)O => 1 (1S,2S,4R)-limonene-1,2-diol." [] xref: EC:3.3.2.8 xref: GO:0018744 "molecular_function:limonene-1,2-epoxide hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC07271 {cardinality="1", is_alternate="False", is_primary="True"} ! (4R)-limonene 1,2-epoxide relationship: has_input_compound UPa:UPC07271 ! (4R)-limonene 1,2-epoxide relationship: has_output_compound UPa:UPC07276 ! (1S,2S,4R)-limonene-1,2-diol relationship: has_output_compound UPa:UPC07276 {cardinality="1", is_alternate="False", is_primary="True"} ! (1S,2S,4R)-limonene-1,2-diol relationship: part_of UPa:ULS00428 ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene relationship: part_of UPa:ULS00428 {cardinality="1", order="2"} ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene [Term] id: UPa:UER00866 name: (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 3/3 namespace: enzymatic_reaction def: "1 (1S,2S,4R)-limonene-1,2-diol + 1 NAD(+) => 1 (1S,4R)-1-hydroxylimonen-2-one + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.297 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC07276 {cardinality="1", is_alternate="False", is_primary="True"} ! (1S,2S,4R)-limonene-1,2-diol relationship: has_input_compound UPa:UPC07276 ! (1S,2S,4R)-limonene-1,2-diol relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC11937 {cardinality="1", is_alternate="False", is_primary="True"} ! (1S,4R)-1-hydroxylimonen-2-one relationship: has_output_compound UPa:UPC11937 ! (1S,4R)-1-hydroxylimonen-2-one relationship: part_of UPa:ULS00428 ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene relationship: part_of UPa:ULS00428 {cardinality="1", order="3"} ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene [Term] id: UPa:UER00867 name: (1R,4S)-isodihydrocarvone from (4R)-limonene: step 1/3 namespace: enzymatic_reaction def: "1 (4R)-limonene + 1 H(+) + 1 NADPH + 1 O(2) => 1 (4S,6R)-trans-carveol + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.80 xref: GO:0052741 "molecular_function:(R)-limonene 6-monooxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC06099 ! (4R)-limonene relationship: has_input_compound UPa:UPC06099 {cardinality="1", is_alternate="False", is_primary="True"} ! (4R)-limonene relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC11409 ! (4S,6R)-trans-carveol relationship: has_output_compound UPa:UPC11409 {cardinality="1", is_alternate="False", is_primary="True"} ! (4S,6R)-trans-carveol relationship: part_of UPa:ULS00429 ! (1R,4S)-isodihydrocarvone from (4R)-limonene relationship: part_of UPa:ULS00429 {cardinality="1", order="1"} ! (1R,4S)-isodihydrocarvone from (4R)-limonene [Term] id: UPa:UER00868 name: (1R,4S)-isodihydrocarvone from (4R)-limonene: step 2/3 namespace: enzymatic_reaction def: "1 (4S,6R)-trans-carveol + 1 NAD(+) => 1 (S)-carvone + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.275 xref: GO:0033702 "molecular_function:(+)-trans-carveol dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC11409 ! (4S,6R)-trans-carveol relationship: has_input_compound UPa:UPC11409 {cardinality="1", is_alternate="False", is_primary="True"} ! (4S,6R)-trans-carveol relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC11383 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-carvone relationship: has_output_compound UPa:UPC11383 ! (S)-carvone relationship: part_of UPa:ULS00429 ! (1R,4S)-isodihydrocarvone from (4R)-limonene relationship: part_of UPa:ULS00429 {cardinality="1", order="2"} ! (1R,4S)-isodihydrocarvone from (4R)-limonene [Term] id: UPa:UER00869 name: (1R,4S)-isodihydrocarvone from (4R)-limonene: step 3/3 namespace: enzymatic_reaction def: "1 (S)-carvone + 1 reduced acceptor => 1 (1R,4S)-isodihydrocarvone + 1 acceptor." [] xref: EC:1.3.99.25 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00030 ! reduced acceptor relationship: has_input_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_input_compound UPa:UPC11383 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-carvone relationship: has_input_compound UPa:UPC11383 ! (S)-carvone relationship: has_output_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_output_compound UPa:UPC00028 ! acceptor relationship: has_output_compound UPa:UPC11412 ! (1R,4S)-isodihydrocarvone relationship: has_output_compound UPa:UPC11412 {cardinality="1", is_alternate="False", is_primary="True"} ! (1R,4S)-isodihydrocarvone relationship: part_of UPa:ULS00429 ! (1R,4S)-isodihydrocarvone from (4R)-limonene relationship: part_of UPa:ULS00429 {cardinality="1", order="3"} ! (1R,4S)-isodihydrocarvone from (4R)-limonene [Term] id: UPa:UER00870 name: formaldehyde from methylamine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 amicyanin + 1 methylamine => 2 H(+) + 1 NH(3) + 1 formaldehyde + 1 reduced amicyanin." [] xref: EC:1.4.9.1 xref: GO:0030058 "molecular_function:amine dehydrogenase activity" xref: GO:0052876 "molecular_function:methylamine dehydrogenase (amicyanin) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00218 ! methylamine relationship: has_input_compound UPa:UPC00218 {cardinality="1", is_alternate="False", is_primary="True"} ! methylamine relationship: has_input_compound UPa:UPC19671 {cardinality="1", is_alternate="False", is_primary="False"} ! amicyanin relationship: has_input_compound UPa:UPC19671 ! amicyanin relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00067 {cardinality="1", is_alternate="False", is_primary="True"} ! formaldehyde relationship: has_output_compound UPa:UPC00067 ! formaldehyde relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC19672 ! reduced amicyanin relationship: has_output_compound UPa:UPC19672 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced amicyanin relationship: part_of UPa:ULS00430 ! formaldehyde from methylamine relationship: part_of UPa:ULS00430 {cardinality="1", order="1"} ! formaldehyde from methylamine [Term] id: UPa:UER00871 name: S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 S-methyl-5'-thioadenosine => 1 5-methylthio-alpha-D-ribose + 1 adenine." [] xref: EC:3.2.2.16 xref: GO:0008930 "molecular_function:methylthioadenosine nucleosidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine relationship: has_input_compound UPa:UPC00170 {cardinality="1", is_alternate="False", is_primary="True"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00147 ! adenine relationship: has_output_compound UPa:UPC00147 {cardinality="1", is_alternate="False", is_primary="False"} ! adenine relationship: has_output_compound UPa:UPC03089 ! 5-methylthio-alpha-D-ribose relationship: has_output_compound UPa:UPC03089 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-methylthio-alpha-D-ribose relationship: part_of UPa:ULS00432 {cardinality="1", order="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route) relationship: part_of UPa:ULS00432 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route) [Term] id: UPa:UER00872 name: S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 2/2 namespace: enzymatic_reaction def: "1 5-methylthio-alpha-D-ribose + 1 ATP => 1 ADP + 1 S-methyl-5-thio-alpha-D-ribose 1-phosphate." [] xref: EC:2.7.1.100 xref: GO:0046522 "molecular_function:S-methyl-5-thioribose kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC03089 ! 5-methylthio-alpha-D-ribose relationship: has_input_compound UPa:UPC03089 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-methylthio-alpha-D-ribose relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC04188 {cardinality="1", is_alternate="False", is_primary="True"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC04188 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00432 {cardinality="1", order="2"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route) relationship: part_of UPa:ULS00432 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route) [Term] id: UPa:UER00873 name: S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1 namespace: enzymatic_reaction def: "1 S-methyl-5'-thioadenosine + 1 phosphate => 1 S-methyl-5-thio-alpha-D-ribose 1-phosphate + 1 adenine." [] xref: EC:2.4.2.28 xref: GO:0017061 "molecular_function:S-methyl-5-thioadenosine phosphorylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine relationship: has_input_compound UPa:UPC00170 {cardinality="1", is_alternate="False", is_primary="True"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00147 ! adenine relationship: has_output_compound UPa:UPC00147 {cardinality="1", is_alternate="False", is_primary="False"} ! adenine relationship: has_output_compound UPa:UPC04188 {cardinality="1", is_alternate="False", is_primary="True"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC04188 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00433 {cardinality="1", order="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route) relationship: part_of UPa:ULS00433 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route) [Term] id: UPa:UER00874 name: L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6 namespace: enzymatic_reaction def: "1 S-methyl-5-thio-alpha-D-ribose 1-phosphate => 1 S-methyl-5-thio-D-ribulose 1-phosphate." [] xref: EC:5.3.1.23 xref: GO:0046523 "molecular_function:S-methyl-5-thioribose-1-phosphate isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04188 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_input_compound UPa:UPC04188 {cardinality="1", is_alternate="False", is_primary="True"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC04582 {cardinality="1", is_alternate="False", is_primary="True"} ! S-methyl-5-thio-D-ribulose 1-phosphate relationship: has_output_compound UPa:UPC04582 ! S-methyl-5-thio-D-ribulose 1-phosphate relationship: part_of UPa:ULS00434 {cardinality="1", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00434 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate [Term] id: UPa:UER00875 name: L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6 namespace: enzymatic_reaction def: "1 S-methyl-5-thio-D-ribulose 1-phosphate => 1 5-(methylthio)-2,3-dioxopentyl phosphate + 1 H(2)O." [] xref: EC:4.2.1.109 xref: GO:0046570 "molecular_function:methylthioribulose 1-phosphate dehydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC04582 ! S-methyl-5-thio-D-ribulose 1-phosphate relationship: has_input_compound UPa:UPC04582 {cardinality="1", is_alternate="False", is_primary="True"} ! S-methyl-5-thio-D-ribulose 1-phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC15650 ! 5-(methylthio)-2,3-dioxopentyl phosphate relationship: has_output_compound UPa:UPC15650 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-(methylthio)-2,3-dioxopentyl phosphate relationship: part_of UPa:ULS00434 {cardinality="1", order="2"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00434 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate [Term] id: UPa:UER00876 name: L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6 namespace: enzymatic_reaction def: "1 5-(methylthio)-2,3-dioxopentyl phosphate => 1 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate." [] xref: EC:5.3.2.5 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC15650 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-(methylthio)-2,3-dioxopentyl phosphate relationship: has_input_compound UPa:UPC15650 ! 5-(methylthio)-2,3-dioxopentyl phosphate relationship: has_output_compound UPa:UPC15651 ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate relationship: has_output_compound UPa:UPC15651 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate relationship: part_of UPa:ULS00434 {cardinality="1", order="3"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00434 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate [Term] id: UPa:UER00877 name: L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6 namespace: enzymatic_reaction def: "1 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate + 1 H(2)O => 1 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + 1 phosphate." [] xref: EC:3.1.3.87 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC15651 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate relationship: has_input_compound UPa:UPC15651 ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC15606 {cardinality="1", is_alternate="False", is_primary="True"} ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one relationship: has_output_compound UPa:UPC15606 ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one relationship: part_of UPa:ULS00434 {cardinality="1", order="4"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00434 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate [Term] id: UPa:UER00878 name: L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6 namespace: enzymatic_reaction def: "1 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + 1 O(2) => 1 4-methylthio-2-oxobutanoate + 1 formate." [] xref: EC:1.13.11.54 xref: GO:0010309 "molecular_function:acireductone dioxygenase [iron(II)-requiring] activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC15606 {cardinality="1", is_alternate="False", is_primary="True"} ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one relationship: has_input_compound UPa:UPC15606 ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_output_compound UPa:UPC01180 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methylthio-2-oxobutanoate relationship: has_output_compound UPa:UPC01180 ! 4-methylthio-2-oxobutanoate relationship: part_of UPa:ULS00434 {cardinality="1", order="5"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00434 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate [Term] id: UPa:UER00879 name: L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6 namespace: enzymatic_reaction def: "1 4-methylthio-2-oxobutanoate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-methionine." [] xref: EC:2.6.1 xref: GO:0008483 "molecular_function:transaminase activity" xref: GO:0010326 "molecular_function:methionine-oxo-acid transaminase activity" xref: GO:0018719 "molecular_function:6-aminohexanoate transaminase activity" xref: GO:0043746 "molecular_function:N2-acetyl-L-lysine aminotransferase activity" xref: GO:0043760 "molecular_function:acetyldiaminopimelate aminotransferase activity" xref: GO:0043840 "molecular_function:branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" xref: GO:0043911 "molecular_function:D-lysine transaminase activity" xref: GO:0046571 "molecular_function:aspartate-2-keto-4-methylthiobutyrate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC01180 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methylthio-2-oxobutanoate relationship: has_input_compound UPa:UPC01180 ! 4-methylthio-2-oxobutanoate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="True"} ! L-methionine relationship: part_of UPa:ULS00434 {cardinality="1", order="6"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00434 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate [Term] id: UPa:UER00880 name: 4-aminobutanoate from putrescine: step 1/4 namespace: enzymatic_reaction def: "1 ATP + 1 L-glutamate + 1 putrescine => 1 ADP + 1 gamma-L-glutamylputrescine + 1 phosphate." [] xref: EC:6.3.1.11 xref: GO:0034024 "molecular_function:glutamate-putrescine ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_input_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC15699 {cardinality="1", is_alternate="False", is_primary="True"} ! gamma-L-glutamylputrescine relationship: has_output_compound UPa:UPC15699 ! gamma-L-glutamylputrescine relationship: part_of UPa:ULS00435 {cardinality="1", order="1"} ! 4-aminobutanoate from putrescine relationship: part_of UPa:ULS00435 ! 4-aminobutanoate from putrescine [Term] id: UPa:UER00881 name: 4-aminobutanoate from putrescine: step 2/4 namespace: enzymatic_reaction def: "1 H(2)O + 1 O(2) + 1 gamma-L-glutamylputrescine => 1 H(2)O(2) + 1 NH(3) + 1 gamma-glutamyl-4-aminobutanal." [] xref: EC:1.4.3 xref: GO:0015922 "molecular_function:aspartate oxidase activity" xref: GO:0016641 "molecular_function:oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor" xref: GO:0043912 "molecular_function:D-lysine oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC15699 ! gamma-L-glutamylputrescine relationship: has_input_compound UPa:UPC15699 {cardinality="1", is_alternate="False", is_primary="True"} ! gamma-L-glutamylputrescine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC15700 {cardinality="1", is_alternate="False", is_primary="True"} ! gamma-glutamyl-4-aminobutanal relationship: has_output_compound UPa:UPC15700 ! gamma-glutamyl-4-aminobutanal relationship: part_of UPa:ULS00435 {cardinality="1", order="2"} ! 4-aminobutanoate from putrescine relationship: part_of UPa:ULS00435 ! 4-aminobutanoate from putrescine [Term] id: UPa:UER00882 name: 4-aminobutanoate from putrescine: step 3/4 namespace: enzymatic_reaction def: "H(2)O + gamma-glutamyl-4-aminobutanal + [NAD(+) or NADP(+)] => 4-(L-gamma-glutamylamino)butanoic acid + H(+) + [NADH or NADPH]." [] xref: EC:1.2.1 xref: GO:0004028 "molecular_function:3-chloroallyl aldehyde dehydrogenase activity" xref: GO:0016620 "molecular_function:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" xref: GO:0018472 "molecular_function:1-hydroxy-2-naphthaldehyde dehydrogenase activity" xref: GO:0018473 "molecular_function:cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity" xref: GO:0018474 "molecular_function:2-carboxybenzaldehyde dehydrogenase activity" xref: GO:0018475 "molecular_function:trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity" xref: GO:0019115 "molecular_function:benzaldehyde dehydrogenase activity" xref: GO:0034520 "molecular_function:2-naphthaldehyde dehydrogenase activity" xref: GO:0034525 "molecular_function:1-naphthaldehyde dehydrogenase activity" xref: GO:0034530 "molecular_function:4-hydroxymethylsalicyaldehyde dehydrogenase activity" xref: GO:0034538 "molecular_function:3-methylsalicylaldehyde dehydrogenase activity" xref: GO:0034601 "molecular_function:oxoglutarate dehydrogenase [NAD(P)+] activity" xref: GO:0034602 "molecular_function:oxoglutarate dehydrogenase (NAD+) activity" xref: GO:0034603 "molecular_function:pyruvate dehydrogenase [NAD(P)+] activity" xref: GO:0034604 "molecular_function:pyruvate dehydrogenase (NAD+) activity" xref: GO:0034822 "molecular_function:citronellal dehydrogenase activity" xref: GO:0034832 "molecular_function:geranial dehydrogenase activity" xref: GO:0043745 "molecular_function:N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity" xref: GO:0043796 "molecular_function:glyceraldehyde dehydrogenase (NADP) activity" xref: GO:0043870 "molecular_function:N-acetyl-gamma-aminoadipyl-phosphate reductase activity" xref: GO:0043878 "molecular_function:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity" xref: GO:0044104 "molecular_function:2,5-dioxovalerate dehydrogenase (NAD+) activity" xref: GO:0052814 "molecular_function:medium-chain-aldehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER00989 ! None relationship: has_alternate_enzymatic_reaction UPa:UER00990 ! None relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC15700 ! gamma-glutamyl-4-aminobutanal relationship: has_input_compound UPa:UPC15700 {cardinality="1", is_alternate="False", is_primary="True"} ! gamma-glutamyl-4-aminobutanal relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC15767 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-(L-gamma-glutamylamino)butanoic acid relationship: has_output_compound UPa:UPC15767 ! 4-(L-gamma-glutamylamino)butanoic acid relationship: part_of UPa:ULS00435 {cardinality="1", order="3"} ! 4-aminobutanoate from putrescine relationship: part_of UPa:ULS00435 ! 4-aminobutanoate from putrescine [Term] id: UPa:UER00883 name: 4-aminobutanoate from putrescine: step 4/4 namespace: enzymatic_reaction def: "1 4-(L-gamma-glutamylamino)butanoic acid + 1 H(2)O => 1 4-aminobutanoate + 1 L-glutamate." [] xref: EC:3.5.1.94 xref: GO:0033969 "molecular_function:gamma-glutamyl-gamma-aminobutyrate hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC15767 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-(L-gamma-glutamylamino)butanoic acid relationship: has_input_compound UPa:UPC15767 ! 4-(L-gamma-glutamylamino)butanoic acid relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00334 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanoate relationship: has_output_compound UPa:UPC00334 ! 4-aminobutanoate relationship: part_of UPa:ULS00435 ! 4-aminobutanoate from putrescine relationship: part_of UPa:ULS00435 {cardinality="1", order="4"} ! 4-aminobutanoate from putrescine [Term] id: UPa:UER00884 name: ppGpp from GTP: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 GTP => 1 AMP + 1 guanosine 3'-diphosphate 5'-triphosphate." [] xref: EC:2.7.6.5 xref: GO:0008728 "molecular_function:GTP diphosphokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00044 {cardinality="1", is_alternate="False", is_primary="True"} ! GTP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC04494 {cardinality="1", is_alternate="False", is_primary="True"} ! guanosine 3'-diphosphate 5'-triphosphate relationship: has_output_compound UPa:UPC04494 ! guanosine 3'-diphosphate 5'-triphosphate relationship: part_of UPa:ULS00436 {cardinality="1", order="1"} ! ppGpp from GTP relationship: part_of UPa:ULS00436 ! ppGpp from GTP [Term] id: UPa:UER00885 name: ppGpp from GTP: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 guanosine 3'-diphosphate 5'-triphosphate => 1 phosphate + 1 ppGpp." [] xref: EC:3.6.1.40 xref: GO:0008894 "molecular_function:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC04494 ! guanosine 3'-diphosphate 5'-triphosphate relationship: has_input_compound UPa:UPC04494 {cardinality="1", is_alternate="False", is_primary="True"} ! guanosine 3'-diphosphate 5'-triphosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC01228 ! ppGpp relationship: has_output_compound UPa:UPC01228 {cardinality="1", is_alternate="False", is_primary="True"} ! ppGpp relationship: part_of UPa:ULS00436 ! ppGpp from GTP relationship: part_of UPa:ULS00436 {cardinality="1", order="2"} ! ppGpp from GTP [Term] id: UPa:UER00886 name: ppGpp from GDP: step 1/1 namespace: enzymatic_reaction def: "1 GDP + 1 diphosphate => 1 H(2)O + 1 ppGpp." [] xref: EC:3.1.7.2 xref: GO:0008893 "molecular_function:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_input_compound UPa:UPC00013 ! diphosphate relationship: has_input_compound UPa:UPC00035 ! GDP relationship: has_input_compound UPa:UPC00035 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC01228 ! ppGpp relationship: has_output_compound UPa:UPC01228 {cardinality="1", is_alternate="False", is_primary="True"} ! ppGpp relationship: part_of UPa:ULS00437 ! ppGpp from GDP relationship: part_of UPa:ULS00437 {cardinality="1", order="1"} ! ppGpp from GDP [Term] id: UPa:UER00887 name: GMP from guanine: step 1/1 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 guanine => 1 GMP + 1 diphosphate." [] xref: EC:2.4.2.8 xref: GO:0004422 "molecular_function:hypoxanthine phosphoribosyltransferase activity" xref: GO:0052657 "molecular_function:guanine phosphoribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00242 ! guanine relationship: has_input_compound UPa:UPC00242 {cardinality="1", is_alternate="False", is_primary="True"} ! guanine relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00144 {cardinality="1", is_alternate="False", is_primary="True"} ! GMP relationship: has_output_compound UPa:UPC00144 ! GMP relationship: part_of UPa:ULS00438 ! GMP from guanine relationship: part_of UPa:ULS00438 {cardinality="1", order="1"} ! GMP from guanine [Term] id: UPa:UER00888 name: D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2 namespace: enzymatic_reaction def: "1 beta-D-ribopyranose => 1 D-ribose." [] xref: EC:5.4.99 xref: GO:0034784 "molecular_function:pivalyl-CoA mutase activity" xref: GO:0034951 "molecular_function:o-hydroxylaminobenzoate mutase activity" xref: GO:0042299 "molecular_function:lupeol synthase activity" xref: GO:0042300 "molecular_function:beta-amyrin synthase activity" xref: GO:0080011 "molecular_function:baruol synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC08353 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-D-ribopyranose relationship: has_input_compound UPa:UPC08353 ! beta-D-ribopyranose relationship: has_output_compound UPa:UPC00121 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose relationship: has_output_compound UPa:UPC00121 ! D-ribose relationship: part_of UPa:ULS00439 ! D-ribose 5-phosphate from beta-D-ribopyranose relationship: part_of UPa:ULS00439 {cardinality="1", order="1"} ! D-ribose 5-phosphate from beta-D-ribopyranose [Term] id: UPa:UER00889 name: D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2 namespace: enzymatic_reaction def: "1 ATP + 1 D-ribose => 1 ADP + 1 D-ribose 5-phosphate." [] xref: EC:2.7.1.15 xref: GO:0004747 "molecular_function:ribokinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00121 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose relationship: has_input_compound UPa:UPC00121 ! D-ribose relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00117 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: part_of UPa:ULS00439 ! D-ribose 5-phosphate from beta-D-ribopyranose relationship: part_of UPa:ULS00439 {cardinality="1", order="2"} ! D-ribose 5-phosphate from beta-D-ribopyranose [Term] id: UPa:UER00890 name: nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 nicotinamide => 1 diphosphate + 1 nicotinamide D-ribonucleotide." [] xref: EC:2.4.2.12 xref: GO:0047280 "molecular_function:nicotinamide phosphoribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00153 ! nicotinamide relationship: has_input_compound UPa:UPC00153 {cardinality="1", is_alternate="False", is_primary="True"} ! nicotinamide relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00455 {cardinality="1", is_alternate="False", is_primary="True"} ! nicotinamide D-ribonucleotide relationship: has_output_compound UPa:UPC00455 ! nicotinamide D-ribonucleotide relationship: part_of UPa:ULS00440 {cardinality="1", order="1"} ! nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide relationship: part_of UPa:ULS00440 ! nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide [Term] id: UPa:UER00891 name: formate from pyruvate: step 1/1 namespace: enzymatic_reaction def: "1 CoA + 1 pyruvate => 1 acetyl-CoA + 1 formate." [] xref: EC:2.3.1.54 xref: GO:0008861 "molecular_function:formate C-acetyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="True"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: part_of UPa:ULS00441 ! formate from pyruvate relationship: part_of UPa:ULS00441 {cardinality="1", order="1"} ! formate from pyruvate [Term] id: UPa:UER00892 name: stachyose from raffinose: step 1/1 namespace: enzymatic_reaction def: "1 1-alpha-D-galactosyl-myo-inositol + 1 raffinose => 1 myo-inositol + 1 stachyose." [] xref: EC:2.4.1.67 xref: GO:0047268 "molecular_function:galactinol-raffinose galactosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00492 {cardinality="1", is_alternate="False", is_primary="True"} ! raffinose relationship: has_input_compound UPa:UPC00492 ! raffinose relationship: has_input_compound UPa:UPC01235 ! 1-alpha-D-galactosyl-myo-inositol relationship: has_input_compound UPa:UPC01235 {cardinality="1", is_alternate="False", is_primary="False"} ! 1-alpha-D-galactosyl-myo-inositol relationship: has_output_compound UPa:UPC00137 ! myo-inositol relationship: has_output_compound UPa:UPC00137 {cardinality="1", is_alternate="False", is_primary="False"} ! myo-inositol relationship: has_output_compound UPa:UPC01613 {cardinality="1", is_alternate="False", is_primary="True"} ! stachyose relationship: has_output_compound UPa:UPC01613 ! stachyose relationship: part_of UPa:ULS00442 {cardinality="1", order="1"} ! stachyose from raffinose relationship: part_of UPa:ULS00442 ! stachyose from raffinose [Term] id: UPa:UER00893 name: formaldehyde from methanol: step 1/1 namespace: enzymatic_reaction def: "1 NAD(+) + 1 methanol => 1 H(+) + 1 NADH + 1 formaldehyde." [] xref: EC:1.1.1.244 xref: GO:0050093 "molecular_function:methanol dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00132 ! methanol relationship: has_input_compound UPa:UPC00132 {cardinality="1", is_alternate="False", is_primary="True"} ! methanol relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00067 {cardinality="1", is_alternate="False", is_primary="True"} ! formaldehyde relationship: has_output_compound UPa:UPC00067 ! formaldehyde relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:ULS00443 {cardinality="1", order="1"} ! formaldehyde from methanol relationship: part_of UPa:ULS00443 ! formaldehyde from methanol [Term] id: UPa:UER00894 name: acetoacetyl-CoA from succinyl-CoA: step 1/1 namespace: enzymatic_reaction def: "1 acetoacetate + 1 succinyl-CoA => 1 acetoacetyl-CoA + 1 succinate." [] xref: EC:2.8.3.5 xref: GO:0008260 "molecular_function:3-oxoacid CoA-transferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="True"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00164 {cardinality="1", is_alternate="False", is_primary="False"} ! acetoacetate relationship: has_input_compound UPa:UPC00164 ! acetoacetate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00332 ! acetoacetyl-CoA relationship: has_output_compound UPa:UPC00332 {cardinality="1", is_alternate="False", is_primary="True"} ! acetoacetyl-CoA relationship: part_of UPa:ULS00444 {cardinality="1", order="1"} ! acetoacetyl-CoA from succinyl-CoA relationship: part_of UPa:ULS00444 ! acetoacetyl-CoA from succinyl-CoA [Term] id: UPa:UER00895 name: L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 L-serine + 1 tRNA(Sec) => 1 AMP + 1 L-seryl-tRNA(Sec) + 1 diphosphate." [] xref: EC:6.1.1.11 xref: GO:0004828 "molecular_function:serine-tRNA ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="True"} ! L-serine relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC16636 {cardinality="1", is_alternate="False", is_primary="True"} ! tRNA(Sec) relationship: has_input_compound UPa:UPC16636 ! tRNA(Sec) relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC06481 ! L-seryl-tRNA(Sec) relationship: has_output_compound UPa:UPC06481 {cardinality="1", is_alternate="False", is_primary="True"} ! L-seryl-tRNA(Sec) relationship: part_of UPa:ULS00445 ! L-seryl-tRNA(Sec) from L-serine and tRNA(Sec) relationship: part_of UPa:ULS00445 {cardinality="1", order="1"} ! L-seryl-tRNA(Sec) from L-serine and tRNA(Sec) [Term] id: UPa:UER00896 name: selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1 namespace: enzymatic_reaction def: "1 L-seryl-tRNA(Sec) + 1 selenophosphate => 1 phosphate + 1 selenocysteinyl-tRNA(Sec)." [] xref: EC:2.9.1.1 xref: GO:0004125 "molecular_function:L-seryl-tRNASec selenium transferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC05172 {cardinality="1", is_alternate="False", is_primary="False"} ! selenophosphate relationship: has_input_compound UPa:UPC05172 ! selenophosphate relationship: has_input_compound UPa:UPC06481 ! L-seryl-tRNA(Sec) relationship: has_input_compound UPa:UPC06481 {cardinality="1", is_alternate="False", is_primary="True"} ! L-seryl-tRNA(Sec) relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC06482 ! selenocysteinyl-tRNA(Sec) relationship: has_output_compound UPa:UPC06482 {cardinality="1", is_alternate="False", is_primary="True"} ! selenocysteinyl-tRNA(Sec) relationship: part_of UPa:ULS00447 ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route) relationship: part_of UPa:ULS00447 {cardinality="1", order="1"} ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route) [Term] id: UPa:UER00897 name: selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 L-seryl-tRNA(Sec) => 1 ADP + 1 O-phosphoseryl-tRNA(Sec)." [] xref: EC:2.7.1.164 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC06481 ! L-seryl-tRNA(Sec) relationship: has_input_compound UPa:UPC06481 {cardinality="1", is_alternate="False", is_primary="True"} ! L-seryl-tRNA(Sec) relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC16638 ! O-phosphoseryl-tRNA(Sec) relationship: has_output_compound UPa:UPC16638 {cardinality="1", is_alternate="False", is_primary="True"} ! O-phosphoseryl-tRNA(Sec) relationship: part_of UPa:ULS00446 {cardinality="1", order="1"} ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route) relationship: part_of UPa:ULS00446 ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route) [Term] id: UPa:UER00898 name: selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 O-phosphoseryl-tRNA(Sec) + 1 selenophosphate => 2 phosphate + 1 selenocysteinyl-tRNA(Sec)." [] xref: EC:2.9.1.2 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC05172 {cardinality="1", is_alternate="False", is_primary="False"} ! selenophosphate relationship: has_input_compound UPa:UPC05172 ! selenophosphate relationship: has_input_compound UPa:UPC16638 {cardinality="1", is_alternate="False", is_primary="True"} ! O-phosphoseryl-tRNA(Sec) relationship: has_input_compound UPa:UPC16638 ! O-phosphoseryl-tRNA(Sec) relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC06482 ! selenocysteinyl-tRNA(Sec) relationship: has_output_compound UPa:UPC06482 {cardinality="1", is_alternate="False", is_primary="True"} ! selenocysteinyl-tRNA(Sec) relationship: part_of UPa:ULS00446 {cardinality="1", order="2"} ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route) relationship: part_of UPa:ULS00446 ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route) [Term] id: UPa:UER00899 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide: step 1/1 namespace: enzymatic_reaction def: "1 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + 1 L-glutamine => 1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 1 D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 1 L-glutamate." [] xref: EC:2.4.2 xref: EC:4.1.3 xref: GO:0000107 "molecular_function:imidazoleglycerol-phosphate synthase activity" xref: GO:0016763 "molecular_function:transferase activity, transferring pentosyl groups" xref: GO:0016833 "molecular_function:oxo-acid-lyase activity" xref: GO:0018071 "molecular_function:NAD(P)-cysteine ADP-ribosyltransferase activity" xref: GO:0018121 "molecular_function:NAD(P)-asparagine ADP-ribosyltransferase activity" xref: GO:0018127 "molecular_function:NAD(P)-serine ADP-ribosyltransferase activity" xref: GO:0034815 "molecular_function:cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity" xref: GO:0034830 "molecular_function:(2Z)-2,4-dihydroxydec-2-enedioate aldolase activity" xref: GO:0034905 "molecular_function:5-chloro-4-hydroxy-2-oxopentanate aldolase activity" xref: GO:0043867 "molecular_function:7-cyano-7-deazaguanine tRNA-ribosyltransferase activity" xref: GO:0043904 "molecular_function:isochorismate pyruvate lyase activity" xref: GO:0043959 "molecular_function:L-erythro-3-methylmalyl-CoA lyase activity" xref: GO:0044101 "molecular_function:(R)-citramalyl-CoA lyase activity" xref: GO:0044102 "molecular_function:purine deoxyribosyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC04916 ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04916 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC04666 ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_output_compound UPa:UPC04666 {cardinality="1", is_alternate="False", is_primary="False"} ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_output_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04677 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00448 {cardinality="1", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00448 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide [Term] id: UPa:UER00900 name: 1,4-dihydroxy-2-naphthoate from chorismate: step 3/7 namespace: enzymatic_reaction def: "1 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid => 1 (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid + 1 pyruvate." [] xref: EC:4.2.99.20 xref: GO:0070205 "molecular_function:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC16519 ! 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid relationship: has_input_compound UPa:UPC16519 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC05817 {cardinality="1", is_alternate="False", is_primary="True"} ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid relationship: has_output_compound UPa:UPC05817 ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid relationship: part_of UPa:ULS00509 {cardinality="1", order="3"} ! 1,4-dihydroxy-2-naphthoate from chorismate relationship: part_of UPa:ULS00509 ! 1,4-dihydroxy-2-naphthoate from chorismate [Term] id: UPa:UER00901 name: acetaldehyde and pyruvate from p-cumate: step 1/7 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 p-cumate => 1 NAD(+) + 1 cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid." [] xref: EC:1.13.11 xref: GO:0016702 "molecular_function:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" xref: GO:0018542 "molecular_function:2,3-dihydroxy DDT 1,2-dioxygenase activity" xref: GO:0018555 "molecular_function:phenanthrene dioxygenase activity" xref: GO:0018556 "molecular_function:2,2',3-trihydroxybiphenyl dioxygenase activity" xref: GO:0018557 "molecular_function:1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity" xref: GO:0018558 "molecular_function:5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity" xref: GO:0018559 "molecular_function:1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity" xref: GO:0018560 "molecular_function:protocatechuate 3,4-dioxygenase type II activity" xref: GO:0018561 "molecular_function:2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity" xref: GO:0018562 "molecular_function:3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity" xref: GO:0018563 "molecular_function:2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity" xref: GO:0018564 "molecular_function:carbazole 1,9a-dioxygenase activity" xref: GO:0018565 "molecular_function:dihydroxydibenzothiophene dioxygenase activity" xref: GO:0018566 "molecular_function:1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity" xref: GO:0018567 "molecular_function:styrene dioxygenase activity" xref: GO:0018568 "molecular_function:3,4-dihydroxyphenanthrene dioxygenase activity" xref: GO:0018569 "molecular_function:hydroquinone 1,2-dioxygenase activity" xref: GO:0018570 "molecular_function:p-cumate 2,3-dioxygenase activity" xref: GO:0018571 "molecular_function:2,3-dihydroxy-p-cumate dioxygenase activity" xref: GO:0018572 "molecular_function:3,5-dichlorocatechol 1,2-dioxygenase activity" xref: GO:0018573 "molecular_function:2-aminophenol 1,6-dioxygenase activity" xref: GO:0018574 "molecular_function:2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity" xref: GO:0018575 "molecular_function:chlorocatechol 1,2-dioxygenase activity" xref: GO:0019114 "molecular_function:catechol dioxygenase activity" xref: GO:0019117 "molecular_function:dihydroxyfluorene dioxygenase activity" xref: GO:0034543 "molecular_function:5-aminosalicylate dioxygenase activity" xref: GO:0034803 "molecular_function:3-hydroxy-2-naphthoate 2,3-dioxygenase activity" xref: GO:0034806 "molecular_function:benzo(a)pyrene 11,12-dioxygenase activity" xref: GO:0034808 "molecular_function:benzo(a)pyrene 4,5-dioxygenase activity" xref: GO:0034810 "molecular_function:4,5-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034811 "molecular_function:benzo(a)pyrene 9,10-dioxygenase activity" xref: GO:0034812 "molecular_function:9,10-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034813 "molecular_function:benzo(a)pyrene 7,8-dioxygenase activity" xref: GO:0034814 "molecular_function:7,8-dihydroxy benzo(a)pyrene dioxygenase activity" xref: GO:0034827 "molecular_function:1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity" xref: GO:0034834 "molecular_function:2-mercaptobenzothiazole dioxygenase activity" xref: GO:0034895 "molecular_function:pyridine-3,4-diol dioxygenase activity" xref: GO:0034920 "molecular_function:pyrene dioxygenase activity" xref: GO:0034922 "molecular_function:4,5-dihydroxypyrene dioxygenase activity" xref: GO:0034934 "molecular_function:phenanthrene-4-carboxylate dioxygenase activity" xref: GO:0034935 "molecular_function:tetrachlorobenzene dioxygenase activity" xref: GO:0034936 "molecular_function:4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity" xref: GO:0034955 "molecular_function:2,3-dihydroxydiphenyl ether dioxygenase activity" xref: GO:0034956 "molecular_function:diphenyl ether 1,2-dioxygenase activity" xref: GO:0036403 "molecular_function:arachidonate 8(S)-lipoxygenase activity" xref: GO:0047074 "molecular_function:4-hydroxycatechol 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC06578 ! p-cumate relationship: has_input_compound UPa:UPC06578 {cardinality="1", is_alternate="False", is_primary="True"} ! p-cumate relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC06579 {cardinality="1", is_alternate="False", is_primary="True"} ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid relationship: has_output_compound UPa:UPC06579 ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid relationship: part_of UPa:ULS00449 ! acetaldehyde and pyruvate from p-cumate relationship: part_of UPa:ULS00449 {cardinality="1", order="1"} ! acetaldehyde and pyruvate from p-cumate [Term] id: UPa:UER00902 name: acetaldehyde and pyruvate from p-cumate: step 2/7 namespace: enzymatic_reaction def: "1 NAD(+) + 1 cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid => 1 2,3-dihydroxy-p-cumic acid + 1 H(+) + 1 NADH." [] xref: EC:1.3.1.58 xref: GO:0018511 "molecular_function:2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC06579 ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid relationship: has_input_compound UPa:UPC06579 {cardinality="1", is_alternate="False", is_primary="True"} ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC06580 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,3-dihydroxy-p-cumic acid relationship: has_output_compound UPa:UPC06580 ! 2,3-dihydroxy-p-cumic acid relationship: part_of UPa:ULS00449 {cardinality="1", order="2"} ! acetaldehyde and pyruvate from p-cumate relationship: part_of UPa:ULS00449 ! acetaldehyde and pyruvate from p-cumate [Term] id: UPa:UER00903 name: acetaldehyde and pyruvate from p-cumate: step 3/7 namespace: enzymatic_reaction def: "1 2,3-dihydroxy-p-cumic acid + 1 O(2) => 1 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid." [] xref: EC:1.13.11 xref: GO:0016702 "molecular_function:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" xref: GO:0018542 "molecular_function:2,3-dihydroxy DDT 1,2-dioxygenase activity" xref: GO:0018555 "molecular_function:phenanthrene dioxygenase activity" xref: GO:0018556 "molecular_function:2,2',3-trihydroxybiphenyl dioxygenase activity" xref: GO:0018557 "molecular_function:1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity" xref: GO:0018558 "molecular_function:5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity" xref: GO:0018559 "molecular_function:1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity" xref: GO:0018560 "molecular_function:protocatechuate 3,4-dioxygenase type II activity" xref: GO:0018561 "molecular_function:2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity" xref: GO:0018562 "molecular_function:3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity" xref: GO:0018563 "molecular_function:2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity" xref: GO:0018564 "molecular_function:carbazole 1,9a-dioxygenase activity" xref: GO:0018565 "molecular_function:dihydroxydibenzothiophene dioxygenase activity" xref: GO:0018566 "molecular_function:1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity" xref: GO:0018567 "molecular_function:styrene dioxygenase activity" xref: GO:0018568 "molecular_function:3,4-dihydroxyphenanthrene dioxygenase activity" xref: GO:0018569 "molecular_function:hydroquinone 1,2-dioxygenase activity" xref: GO:0018570 "molecular_function:p-cumate 2,3-dioxygenase activity" xref: GO:0018571 "molecular_function:2,3-dihydroxy-p-cumate dioxygenase activity" xref: GO:0018572 "molecular_function:3,5-dichlorocatechol 1,2-dioxygenase activity" xref: GO:0018573 "molecular_function:2-aminophenol 1,6-dioxygenase activity" xref: GO:0018574 "molecular_function:2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity" xref: GO:0018575 "molecular_function:chlorocatechol 1,2-dioxygenase activity" xref: GO:0019114 "molecular_function:catechol dioxygenase activity" xref: GO:0019117 "molecular_function:dihydroxyfluorene dioxygenase activity" xref: GO:0034543 "molecular_function:5-aminosalicylate dioxygenase activity" xref: GO:0034803 "molecular_function:3-hydroxy-2-naphthoate 2,3-dioxygenase activity" xref: GO:0034806 "molecular_function:benzo(a)pyrene 11,12-dioxygenase activity" xref: GO:0034808 "molecular_function:benzo(a)pyrene 4,5-dioxygenase activity" xref: GO:0034810 "molecular_function:4,5-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034811 "molecular_function:benzo(a)pyrene 9,10-dioxygenase activity" xref: GO:0034812 "molecular_function:9,10-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034813 "molecular_function:benzo(a)pyrene 7,8-dioxygenase activity" xref: GO:0034814 "molecular_function:7,8-dihydroxy benzo(a)pyrene dioxygenase activity" xref: GO:0034827 "molecular_function:1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity" xref: GO:0034834 "molecular_function:2-mercaptobenzothiazole dioxygenase activity" xref: GO:0034895 "molecular_function:pyridine-3,4-diol dioxygenase activity" xref: GO:0034920 "molecular_function:pyrene dioxygenase activity" xref: GO:0034922 "molecular_function:4,5-dihydroxypyrene dioxygenase activity" xref: GO:0034934 "molecular_function:phenanthrene-4-carboxylate dioxygenase activity" xref: GO:0034935 "molecular_function:tetrachlorobenzene dioxygenase activity" xref: GO:0034936 "molecular_function:4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity" xref: GO:0034955 "molecular_function:2,3-dihydroxydiphenyl ether dioxygenase activity" xref: GO:0034956 "molecular_function:diphenyl ether 1,2-dioxygenase activity" xref: GO:0036403 "molecular_function:arachidonate 8(S)-lipoxygenase activity" xref: GO:0047074 "molecular_function:4-hydroxycatechol 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC06580 {cardinality="1", is_alternate="False", is_primary="True"} ! 2,3-dihydroxy-p-cumic acid relationship: has_input_compound UPa:UPC06580 ! 2,3-dihydroxy-p-cumic acid relationship: has_output_compound UPa:UPC06581 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_output_compound UPa:UPC06581 ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: part_of UPa:ULS00449 {cardinality="1", order="3"} ! acetaldehyde and pyruvate from p-cumate relationship: part_of UPa:ULS00449 ! acetaldehyde and pyruvate from p-cumate [Term] id: UPa:UER00904 name: acetaldehyde and pyruvate from p-cumate: step 4/7 namespace: enzymatic_reaction def: "1 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid => 1 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid + 1 CO(2)." [] xref: EC:4.1.1 xref: GO:0004611 "molecular_function:phosphoenolpyruvate carboxykinase activity" xref: GO:0008488 "molecular_function:gamma-glutamyl carboxylase activity" xref: GO:0008694 "molecular_function:3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity" xref: GO:0016831 "molecular_function:carboxy-lyase activity" xref: GO:0018791 "molecular_function:2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity" xref: GO:0018792 "molecular_function:bis(4-chlorophenyl)acetate decarboxylase activity" xref: GO:0018793 "molecular_function:3,5-dibromo-4-hydroxybenzoate decarboxylase activity" xref: GO:0018794 "molecular_function:2-hydroxyisobutyrate decarboxylase activity" xref: GO:0018795 "molecular_function:2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity" xref: GO:0034524 "molecular_function:2-hydroxyisophthalate decarboxylase activity" xref: GO:0034782 "molecular_function:dimethylmalonate decarboxylase activity" xref: GO:0034853 "molecular_function:2,4,4-trimethyl-3-oxopentanoate decarboxylase activity" xref: GO:0034854 "molecular_function:4,4-dimethyl-3-oxopentanoate decarboxylase activity" xref: GO:0034879 "molecular_function:2,3,6-trihydroxyisonicotinate decarboxylase activity" xref: GO:0034923 "molecular_function:phenanthrene-4,5-dicarboxylate decarboxylase activity" xref: GO:0034941 "molecular_function:pyrrole-2-carboxylate decarboxylase activity" xref: GO:0034947 "molecular_function:terephthalate decarboxylase activity" xref: GO:0034952 "molecular_function:malonate semialdehyde decarboxylase activity" xref: GO:0043727 "molecular_function:5-amino-4-imidazole carboxylate lyase activity" xref: GO:0043728 "molecular_function:2-keto-4-methylthiobutyrate aminotransferase activity" xref: GO:0051997 "molecular_function:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC06581 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_input_compound UPa:UPC06581 ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC06582 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_output_compound UPa:UPC06582 ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: part_of UPa:ULS00449 ! acetaldehyde and pyruvate from p-cumate relationship: part_of UPa:ULS00449 {cardinality="1", order="4"} ! acetaldehyde and pyruvate from p-cumate [Term] id: UPa:UER00905 name: acetaldehyde and pyruvate from p-cumate: step 5/7 namespace: enzymatic_reaction def: "1 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid + 1 H(2)O => 1 2-hydroxy-2,4-pentadienoate + 1 2-methylpropanoate." [] xref: EC:3.7.1 xref: GO:0016823 "molecular_function:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances" xref: GO:0018736 "molecular_function:6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity" xref: GO:0018737 "molecular_function:2-ketocyclohexane-1-carboxyl-CoA hydrolase activity" xref: GO:0018765 "molecular_function:2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity" xref: GO:0018766 "molecular_function:dihydrophloroglucinol hydrolase activity" xref: GO:0018767 "molecular_function:2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity" xref: GO:0018768 "molecular_function:2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity" xref: GO:0018769 "molecular_function:2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity" xref: GO:0018770 "molecular_function:6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity" xref: GO:0018772 "molecular_function:trioxoheptanoate hydrolase activity" xref: GO:0034545 "molecular_function:fumarylpyruvate hydrolase activity" xref: GO:0034779 "molecular_function:4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity" xref: GO:0034789 "molecular_function:2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity" xref: GO:0034801 "molecular_function:2,4-dinitrocyclohexanone hydrolase activity" xref: GO:0034820 "molecular_function:4,9-DSHA hydrolase activity" xref: GO:0034828 "molecular_function:4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity" xref: GO:0034910 "molecular_function:6-hydroxy-3-succinoylpyridine hydrolase activity" xref: GO:0034948 "molecular_function:2,6-dihydroxypseudooxynicotine hydrolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC06582 ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_input_compound UPa:UPC06582 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_output_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00596 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC02632 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-methylpropanoate relationship: has_output_compound UPa:UPC02632 ! 2-methylpropanoate relationship: part_of UPa:ULS00449 ! acetaldehyde and pyruvate from p-cumate relationship: part_of UPa:ULS00449 {cardinality="1", order="5"} ! acetaldehyde and pyruvate from p-cumate [Term] id: UPa:UER00906 name: acetaldehyde and pyruvate from p-cumate: step 6/7 namespace: enzymatic_reaction def: "1 2-hydroxy-2,4-pentadienoate + 1 H(2)O => 1 4-hydroxy-2-oxopentanoate." [] xref: EC:4.2.1.80 xref: GO:0008684 "molecular_function:2-oxopent-4-enoate hydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00596 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-2,4-pentadienoate relationship: has_input_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC03589 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-hydroxy-2-oxopentanoate relationship: has_output_compound UPa:UPC03589 ! 4-hydroxy-2-oxopentanoate relationship: part_of UPa:ULS00449 {cardinality="1", order="6"} ! acetaldehyde and pyruvate from p-cumate relationship: part_of UPa:ULS00449 ! acetaldehyde and pyruvate from p-cumate [Term] id: UPa:UER00907 name: acetaldehyde and pyruvate from p-cumate: step 7/7 namespace: enzymatic_reaction def: "1 4-hydroxy-2-oxopentanoate => 1 acetaldehyde + 1 pyruvate." [] xref: EC:4.1.3.39 xref: GO:0008701 "molecular_function:4-hydroxy-2-oxovalerate aldolase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03589 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-hydroxy-2-oxopentanoate relationship: has_input_compound UPa:UPC03589 ! 4-hydroxy-2-oxopentanoate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00084 {cardinality="1", is_alternate="False", is_primary="True"} ! acetaldehyde relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: part_of UPa:ULS00449 {cardinality="1", order="7"} ! acetaldehyde and pyruvate from p-cumate relationship: part_of UPa:ULS00449 ! acetaldehyde and pyruvate from p-cumate [Term] id: UPa:UER00908 name: succinyl-CoA from propanoyl-CoA: step 1/3 namespace: enzymatic_reaction def: "1 ATP + 1 bicarbonate + 1 propanoyl-CoA => 1 (S)-methylmalonyl-CoA + 1 ADP + 1 phosphate." [] xref: EC:6.4.1.3 xref: GO:0004658 "molecular_function:propionyl-CoA carboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00100 ! propanoyl-CoA relationship: has_input_compound UPa:UPC00100 {cardinality="1", is_alternate="False", is_primary="True"} ! propanoyl-CoA relationship: has_input_compound UPa:UPC00288 {cardinality="1", is_alternate="False", is_primary="False"} ! bicarbonate relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00683 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-methylmalonyl-CoA relationship: has_output_compound UPa:UPC00683 ! (S)-methylmalonyl-CoA relationship: part_of UPa:ULS00450 {cardinality="1", order="1"} ! succinyl-CoA from propanoyl-CoA relationship: part_of UPa:ULS00450 ! succinyl-CoA from propanoyl-CoA [Term] id: UPa:UER00909 name: succinyl-CoA from propanoyl-CoA: step 2/3 namespace: enzymatic_reaction def: "1 (S)-methylmalonyl-CoA => 1 (R)-methylmalonyl-CoA." [] xref: EC:5.1.99.1 xref: GO:0004493 "molecular_function:methylmalonyl-CoA epimerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00683 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-methylmalonyl-CoA relationship: has_input_compound UPa:UPC00683 ! (S)-methylmalonyl-CoA relationship: has_output_compound UPa:UPC01213 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-methylmalonyl-CoA relationship: has_output_compound UPa:UPC01213 ! (R)-methylmalonyl-CoA relationship: part_of UPa:ULS00450 {cardinality="1", order="2"} ! succinyl-CoA from propanoyl-CoA relationship: part_of UPa:ULS00450 ! succinyl-CoA from propanoyl-CoA [Term] id: UPa:UER00910 name: succinyl-CoA from propanoyl-CoA: step 3/3 namespace: enzymatic_reaction def: "1 (R)-methylmalonyl-CoA => 1 succinyl-CoA." [] xref: EC:5.4.99.2 xref: GO:0004494 "molecular_function:methylmalonyl-CoA mutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC01213 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-methylmalonyl-CoA relationship: has_input_compound UPa:UPC01213 ! (R)-methylmalonyl-CoA relationship: has_output_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="True"} ! succinyl-CoA relationship: part_of UPa:ULS00450 {cardinality="1", order="3"} ! succinyl-CoA from propanoyl-CoA relationship: part_of UPa:ULS00450 ! succinyl-CoA from propanoyl-CoA [Term] id: UPa:UER00911 name: glycine from 2-phosphoglycolate: step 1/3 namespace: enzymatic_reaction def: "1 2-phosphoglycolate + 1 H(2)O => 1 glycolate + 1 phosphate." [] xref: EC:3.1.3.18 xref: GO:0008967 "molecular_function:phosphoglycolate phosphatase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00988 ! 2-phosphoglycolate relationship: has_input_compound UPa:UPC00988 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-phosphoglycolate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00160 {cardinality="1", is_alternate="False", is_primary="True"} ! glycolate relationship: has_output_compound UPa:UPC00160 ! glycolate relationship: part_of UPa:ULS00451 {cardinality="1", order="1"} ! glycine from 2-phosphoglycolate relationship: part_of UPa:ULS00451 ! glycine from 2-phosphoglycolate [Term] id: UPa:UER00912 name: glycine from 2-phosphoglycolate: step 2/3 namespace: enzymatic_reaction def: "1 O(2) + 1 glycolate => 1 H(2)O(2) + 1 glyoxylate." [] xref: EC:1.1.3.15 xref: GO:0003973 "molecular_function:(S)-2-hydroxy-acid oxidase activity" xref: GO:0052852 "molecular_function:very-long-chain-(S)-2-hydroxy-acid oxidase activity" xref: GO:0052853 "molecular_function:long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity" xref: GO:0052854 "molecular_function:medium-chain-(S)-2-hydroxy-acid oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00160 ! glycolate relationship: has_input_compound UPa:UPC00160 {cardinality="1", is_alternate="False", is_primary="True"} ! glycolate relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00048 ! glyoxylate relationship: has_output_compound UPa:UPC00048 {cardinality="1", is_alternate="False", is_primary="True"} ! glyoxylate relationship: part_of UPa:ULS00451 {cardinality="1", order="2"} ! glycine from 2-phosphoglycolate relationship: part_of UPa:ULS00451 ! glycine from 2-phosphoglycolate [Term] id: UPa:UER00913 name: glycine from 2-phosphoglycolate: step 3/3 namespace: enzymatic_reaction def: "1 L-glutamate + 1 glyoxylate => 1 2-oxoglutarate + 1 glycine." [] xref: EC:2.6.1.4 xref: GO:0047958 "molecular_function:glycine:2-oxoglutarate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00048 ! glyoxylate relationship: has_input_compound UPa:UPC00048 {cardinality="1", is_alternate="False", is_primary="True"} ! glyoxylate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="True"} ! glycine relationship: part_of UPa:ULS00451 ! glycine from 2-phosphoglycolate relationship: part_of UPa:ULS00451 {cardinality="1", order="3"} ! glycine from 2-phosphoglycolate [Term] id: UPa:UER00914 name: 3-phospho-D-glycerate from glycine: step 1/4 namespace: enzymatic_reaction def: "1 5,10-methylene-THF + 1 H(2)O + 1 glycine => 1 5,6,7,8-tetrahydrofolate + 1 L-serine." [] xref: EC:2.1.2.1 xref: GO:0004372 "molecular_function:glycine hydroxymethyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="True"} ! glycine relationship: has_input_compound UPa:UPC00143 ! 5,10-methylene-THF relationship: has_input_compound UPa:UPC00143 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,10-methylene-THF relationship: has_output_compound UPa:UPC00065 ! L-serine relationship: has_output_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="True"} ! L-serine relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:ULS00452 {cardinality="1", order="1"} ! 3-phospho-D-glycerate from glycine relationship: part_of UPa:ULS00452 ! 3-phospho-D-glycerate from glycine [Term] id: UPa:UER00915 name: 3-phospho-D-glycerate from glycine: step 2/4 namespace: enzymatic_reaction def: "1 L-serine + 1 pyruvate => 1 3-hydroxypyruvate + 1 L-alanine." [] xref: EC:2.6.1.51 xref: GO:0004760 "molecular_function:serine-pyruvate transaminase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="True"} ! L-serine relationship: has_output_compound UPa:UPC00041 ! L-alanine relationship: has_output_compound UPa:UPC00041 {cardinality="1", is_alternate="False", is_primary="False"} ! L-alanine relationship: has_output_compound UPa:UPC00168 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxypyruvate relationship: has_output_compound UPa:UPC00168 ! 3-hydroxypyruvate relationship: part_of UPa:ULS00452 {cardinality="1", order="2"} ! 3-phospho-D-glycerate from glycine relationship: part_of UPa:ULS00452 ! 3-phospho-D-glycerate from glycine [Term] id: UPa:UER00916 name: 3-phospho-D-glycerate from glycine: step 3/4 namespace: enzymatic_reaction def: "1 3-hydroxypyruvate + 1 H(+) + 1 NADH => 1 D-glycerate + 1 NAD(+)." [] xref: EC:1.1.1.29 xref: GO:0008465 "molecular_function:glycerate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00168 ! 3-hydroxypyruvate relationship: has_input_compound UPa:UPC00168 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxypyruvate relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: has_output_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: part_of UPa:ULS00452 {cardinality="1", order="3"} ! 3-phospho-D-glycerate from glycine relationship: part_of UPa:ULS00452 ! 3-phospho-D-glycerate from glycine [Term] id: UPa:UER00917 name: 3-phospho-D-glycerate from glycine: step 4/4 namespace: enzymatic_reaction def: "1 ATP + 1 D-glycerate => 1 3-phospho-D-glycerate + 1 ADP." [] xref: EC:2.7.1.31 xref: GO:0008887 "molecular_function:glycerate kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_input_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00197 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: part_of UPa:ULS00452 ! 3-phospho-D-glycerate from glycine relationship: part_of UPa:ULS00452 {cardinality="1", order="4"} ! 3-phospho-D-glycerate from glycine [Term] id: UPa:UER00918 name: 6-hydroxypseudooxynicotine from nicotine (R-isomer route): step 1/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 acceptor + 1 nicotine => 1 (R)-6-hydroxynicotine + 1 reduced acceptor." [] xref: EC:1.5.99.4 xref: GO:0018535 "molecular_function:nicotine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC16150 {cardinality="1", is_alternate="False", is_primary="True"} ! nicotine relationship: has_input_compound UPa:UPC16150 ! nicotine relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_output_compound UPa:UPC03043 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-6-hydroxynicotine relationship: has_output_compound UPa:UPC03043 ! (R)-6-hydroxynicotine relationship: part_of UPa:ULS00231 ! 6-hydroxypseudooxynicotine from nicotine (R-isomer route) relationship: part_of UPa:ULS00231 {cardinality="1", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (R-isomer route) [Term] id: UPa:UER00919 name: 6-hydroxypseudooxynicotine from nicotine (S-isomer route): step 2/2 namespace: enzymatic_reaction def: "1 (S)-6-hydroxynicotine + 1 H(2)O + 1 O(2) => 1 6-hydroxypseudooxynicotine + 1 H(2)O(2)." [] xref: EC:1.5.3.5 xref: GO:0018531 "molecular_function:(S)-6-hydroxynicotine oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC01056 ! (S)-6-hydroxynicotine relationship: has_input_compound UPa:UPC01056 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-6-hydroxynicotine relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC01297 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-hydroxypseudooxynicotine relationship: has_output_compound UPa:UPC01297 ! 6-hydroxypseudooxynicotine relationship: part_of UPa:ULS00453 ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route) relationship: part_of UPa:ULS00453 {cardinality="1", order="2"} ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route) [Term] id: UPa:UER00920 name: acetyl-CoA from myo-inositol: step 4/7 namespace: enzymatic_reaction def: "1 5-deoxy-D-glucuronic acid => 1 2-deoxy-5-keto-D-gluconic acid." [] xref: EC:5.3.1 xref: GO:0008786 "molecular_function:allose 6-phosphate isomerase activity" xref: GO:0016861 "molecular_function:intramolecular oxidoreductase activity, interconverting aldoses and ketoses" xref: GO:0043877 "molecular_function:galactosamine-6-phosphate isomerase activity" xref: GO:0043917 "molecular_function:ribose 1,5-bisphosphate isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC16737 ! 5-deoxy-D-glucuronic acid relationship: has_input_compound UPa:UPC16737 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-deoxy-D-glucuronic acid relationship: has_output_compound UPa:UPC06892 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxy-5-keto-D-gluconic acid relationship: has_output_compound UPa:UPC06892 ! 2-deoxy-5-keto-D-gluconic acid relationship: part_of UPa:ULS00061 {cardinality="1", order="4"} ! acetyl-CoA from myo-inositol relationship: part_of UPa:ULS00061 ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00921 name: 2-deoxystreptamine from D-glucose 6-phosphate: step 1/4 namespace: enzymatic_reaction def: "1 D-glucose 6-phosphate => 1 2-deoxy-scyllo-inosose + 1 phosphate." [] xref: EC:4.2.3.124 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_input_compound UPa:UPC00092 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC17209 ! 2-deoxy-scyllo-inosose relationship: has_output_compound UPa:UPC17209 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxy-scyllo-inosose relationship: part_of UPa:ULS00455 ! 2-deoxystreptamine from D-glucose 6-phosphate relationship: part_of UPa:ULS00455 {cardinality="1", order="1"} ! 2-deoxystreptamine from D-glucose 6-phosphate [Term] id: UPa:UER00922 name: 2-deoxystreptamine from D-glucose 6-phosphate: step 2/4 namespace: enzymatic_reaction def: "1 2-deoxy-scyllo-inosose + 1 L-glutamine => 1 2-deoxy-scyllo-inosamine + 1 2-oxoglutaramate." [] xref: EC:2.6.1.100 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC17209 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxy-scyllo-inosose relationship: has_input_compound UPa:UPC17209 ! 2-deoxy-scyllo-inosose relationship: has_output_compound UPa:UPC00940 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutaramate relationship: has_output_compound UPa:UPC00940 ! 2-oxoglutaramate relationship: has_output_compound UPa:UPC17580 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxy-scyllo-inosamine relationship: has_output_compound UPa:UPC17580 ! 2-deoxy-scyllo-inosamine relationship: part_of UPa:ULS00455 ! 2-deoxystreptamine from D-glucose 6-phosphate relationship: part_of UPa:ULS00455 {cardinality="1", order="2"} ! 2-deoxystreptamine from D-glucose 6-phosphate [Term] id: UPa:UER00923 name: 2-deoxystreptamine from D-glucose 6-phosphate: step 3/4 namespace: enzymatic_reaction def: "2-deoxy-scyllo-inosamine + [NAD(+) or NADP(+)] => 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + [NADH or NADPH]." [] xref: EC:1.1.1.329 is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER01031 ! None relationship: has_alternate_enzymatic_reaction UPa:UER01032 ! None relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC17580 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxy-scyllo-inosamine relationship: has_input_compound UPa:UPC17580 ! 2-deoxy-scyllo-inosamine relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC17581 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: has_output_compound UPa:UPC17581 ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: part_of UPa:ULS00455 {cardinality="1", order="3"} ! 2-deoxystreptamine from D-glucose 6-phosphate relationship: part_of UPa:ULS00455 ! 2-deoxystreptamine from D-glucose 6-phosphate [Term] id: UPa:UER00924 name: 2-deoxystreptamine from D-glucose 6-phosphate: step 4/4 namespace: enzymatic_reaction def: "1 3-amino-2,3-dideoxy-scyllo-inosose + 1 L-glutamine => 1 2-deoxystreptamine + 1 2-oxoglutaramate." [] xref: EC:2.6.1.101 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC17581 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: has_input_compound UPa:UPC17581 ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: has_output_compound UPa:UPC00940 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutaramate relationship: has_output_compound UPa:UPC00940 ! 2-oxoglutaramate relationship: has_output_compound UPa:UPC02627 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxystreptamine relationship: has_output_compound UPa:UPC02627 ! 2-deoxystreptamine relationship: part_of UPa:ULS00455 {cardinality="1", order="4"} ! 2-deoxystreptamine from D-glucose 6-phosphate relationship: part_of UPa:ULS00455 ! 2-deoxystreptamine from D-glucose 6-phosphate [Term] id: UPa:UER00925 name: (4S)-limonene from geranyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 geranyl diphosphate => 1 (4S)-limonene + 1 diphosphate." [] xref: EC:4.2.3.16 xref: GO:0050552 "molecular_function:(4S)-limonene synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 {cardinality="1", is_alternate="False", is_primary="True"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00521 ! (4S)-limonene relationship: has_output_compound UPa:UPC00521 {cardinality="1", is_alternate="False", is_primary="True"} ! (4S)-limonene relationship: part_of UPa:ULS00456 ! (4S)-limonene from geranyl diphosphate relationship: part_of UPa:ULS00456 {cardinality="1", order="1"} ! (4S)-limonene from geranyl diphosphate [Term] id: UPa:UER00926 name: (4R)-limonene from geranyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 geranyl diphosphate => 1 (4R)-limonene + 1 diphosphate." [] xref: EC:4.2.3.20 xref: GO:0034002 "molecular_function:(R)-limonene synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 {cardinality="1", is_alternate="False", is_primary="True"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC06099 ! (4R)-limonene relationship: has_output_compound UPa:UPC06099 {cardinality="1", is_alternate="False", is_primary="True"} ! (4R)-limonene relationship: part_of UPa:ULS00457 ! (4R)-limonene from geranyl diphosphate relationship: part_of UPa:ULS00457 {cardinality="1", order="1"} ! (4R)-limonene from geranyl diphosphate [Term] id: UPa:UER00927 name: (-)-alpha-pinene from geranyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 geranyl diphosphate => 1 (-)-alpha-pinene + 1 diphosphate." [] xref: EC:4.2.3.119 xref: GO:0050550 "molecular_function:pinene synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 {cardinality="1", is_alternate="False", is_primary="True"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC06308 {cardinality="1", is_alternate="False", is_primary="True"} ! (-)-alpha-pinene relationship: has_output_compound UPa:UPC06308 ! (-)-alpha-pinene relationship: part_of UPa:ULS00458 {cardinality="1", order="1"} ! (-)-alpha-pinene from geranyl diphosphate relationship: part_of UPa:ULS00458 ! (-)-alpha-pinene from geranyl diphosphate [Term] id: UPa:UER00928 name: (-)-beta-pinene from geranyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 geranyl diphosphate => 1 (-)-beta-pinene + 1 diphosphate." [] xref: EC:4.2.3.120 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 {cardinality="1", is_alternate="False", is_primary="True"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC06307 {cardinality="1", is_alternate="False", is_primary="True"} ! (-)-beta-pinene relationship: has_output_compound UPa:UPC06307 ! (-)-beta-pinene relationship: part_of UPa:ULS00459 {cardinality="1", order="1"} ! (-)-beta-pinene from geranyl diphosphate relationship: part_of UPa:ULS00459 ! (-)-beta-pinene from geranyl diphosphate [Term] id: UPa:UER00929 name: FMN from riboflavin (CTP route): step 1/1 namespace: enzymatic_reaction def: "1 CTP + 1 riboflavin => 1 CDP + 1 FMN." [] xref: EC:2.7.1.161 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00063 {cardinality="1", is_alternate="False", is_primary="False"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00255 ! riboflavin relationship: has_input_compound UPa:UPC00255 {cardinality="1", is_alternate="False", is_primary="True"} ! riboflavin relationship: has_output_compound UPa:UPC00061 {cardinality="1", is_alternate="False", is_primary="True"} ! FMN relationship: has_output_compound UPa:UPC00061 ! FMN relationship: has_output_compound UPa:UPC00112 ! CDP relationship: has_output_compound UPa:UPC00112 {cardinality="1", is_alternate="False", is_primary="False"} ! CDP relationship: part_of UPa:ULS00460 ! FMN from riboflavin (CTP route) relationship: part_of UPa:ULS00460 {cardinality="1", order="1"} ! FMN from riboflavin (CTP route) [Term] id: UPa:UER00930 name: GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1 namespace: enzymatic_reaction def: "1 GTP + 1 alpha-D-mannose 1-phosphate => 1 GDP-alpha-D-mannose + 1 diphosphate." [] xref: EC:2.7.7.13 xref: GO:0004475 "molecular_function:mannose-1-phosphate guanylyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00044 {cardinality="1", is_alternate="False", is_primary="False"} ! GTP relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00636 ! alpha-D-mannose 1-phosphate relationship: has_input_compound UPa:UPC00636 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-mannose 1-phosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00096 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-alpha-D-mannose relationship: part_of UPa:ULS00462 {cardinality="1", order="1"} ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route) relationship: part_of UPa:ULS00462 ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route) [Term] id: UPa:UER00931 name: L-ascorbate from GDP-alpha-D-mannose: step 1/5 namespace: enzymatic_reaction def: "1 GDP-alpha-D-mannose => 1 GDP-L-galactose." [] xref: EC:5.1.3.18 xref: GO:0047918 "molecular_function:GDP-mannose 3,5-epimerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00096 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC02280 ! GDP-L-galactose relationship: has_output_compound UPa:UPC02280 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-L-galactose relationship: part_of UPa:ULS00464 {cardinality="1", order="1"} ! L-ascorbate from GDP-alpha-D-mannose relationship: part_of UPa:ULS00464 ! L-ascorbate from GDP-alpha-D-mannose [Term] id: UPa:UER00932 name: L-ascorbate from GDP-alpha-D-mannose: step 2/5 namespace: enzymatic_reaction def: "1 GDP-L-galactose + 1 phosphate => 1 GDP + 1 beta-L-galactose 1-phosphate." [] xref: EC:2.7.7.69 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC02280 ! GDP-L-galactose relationship: has_input_compound UPa:UPC02280 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-L-galactose relationship: has_output_compound UPa:UPC00035 ! GDP relationship: has_output_compound UPa:UPC00035 {cardinality="1", is_alternate="False", is_primary="False"} ! GDP relationship: has_output_compound UPa:UPC15926 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-L-galactose 1-phosphate relationship: has_output_compound UPa:UPC15926 ! beta-L-galactose 1-phosphate relationship: part_of UPa:ULS00464 {cardinality="1", order="2"} ! L-ascorbate from GDP-alpha-D-mannose relationship: part_of UPa:ULS00464 ! L-ascorbate from GDP-alpha-D-mannose [Term] id: UPa:UER00933 name: L-ascorbate from GDP-alpha-D-mannose: step 3/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 beta-L-galactose 1-phosphate => 1 alpha-L-galactose + 1 phosphate." [] xref: EC:3.1.3.93 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC15926 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-L-galactose 1-phosphate relationship: has_input_compound UPa:UPC15926 ! beta-L-galactose 1-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC01825 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-L-galactose relationship: has_output_compound UPa:UPC01825 ! alpha-L-galactose relationship: part_of UPa:ULS00464 {cardinality="1", order="3"} ! L-ascorbate from GDP-alpha-D-mannose relationship: part_of UPa:ULS00464 ! L-ascorbate from GDP-alpha-D-mannose [Term] id: UPa:UER00934 name: L-ascorbate from GDP-alpha-D-mannose: step 4/5 namespace: enzymatic_reaction def: "1 NAD(+) + 1 alpha-L-galactose => 1 H(+) + 1 L-Galactono-1,4-lactone + 1 NADH." [] xref: EC:1.1.1.316 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC01825 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-L-galactose relationship: has_input_compound UPa:UPC01825 ! alpha-L-galactose relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC01115 {cardinality="1", is_alternate="False", is_primary="True"} ! L-Galactono-1,4-lactone relationship: has_output_compound UPa:UPC01115 ! L-Galactono-1,4-lactone relationship: part_of UPa:ULS00464 {cardinality="1", order="4"} ! L-ascorbate from GDP-alpha-D-mannose relationship: part_of UPa:ULS00464 ! L-ascorbate from GDP-alpha-D-mannose [Term] id: UPa:UER00935 name: L-ascorbate from GDP-alpha-D-mannose: step 5/5 namespace: enzymatic_reaction def: "1 L-Galactono-1,4-lactone + 2 ferricytochrome c => 2 H(+) + 1 L-ascorbate + 2 ferrocytochrome c." [] xref: EC:1.3.2.3 xref: GO:0016633 "molecular_function:galactonolactone dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00125 {cardinality="1", is_alternate="False", is_primary="False"} ! ferricytochrome c relationship: has_input_compound UPa:UPC00125 ! ferricytochrome c relationship: has_input_compound UPa:UPC01115 {cardinality="1", is_alternate="False", is_primary="True"} ! L-Galactono-1,4-lactone relationship: has_input_compound UPa:UPC01115 ! L-Galactono-1,4-lactone relationship: has_output_compound UPa:UPC00072 ! L-ascorbate relationship: has_output_compound UPa:UPC00072 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ascorbate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00126 {cardinality="1", is_alternate="False", is_primary="False"} ! ferrocytochrome c relationship: has_output_compound UPa:UPC00126 ! ferrocytochrome c relationship: part_of UPa:ULS00464 ! L-ascorbate from GDP-alpha-D-mannose relationship: part_of UPa:ULS00464 {cardinality="1", order="5"} ! L-ascorbate from GDP-alpha-D-mannose [Term] id: UPa:UER00936 name: L-ascorbate from UDP-alpha-D-glucuronate: step 1/4 namespace: enzymatic_reaction def: "1 H(2)O + 1 UDP-alpha-D-glucuronate => 1 D-glucuronate + 1 UDP." [] xref: EC:3.2.1 xref: GO:0004553 "molecular_function:hydrolase activity, hydrolyzing O-glycosyl compounds" xref: GO:0008933 "molecular_function:lytic transglycosylase activity" xref: GO:0015923 "molecular_function:mannosidase activity" xref: GO:0015924 "molecular_function:mannosyl-oligosaccharide mannosidase activity" xref: GO:0015925 "molecular_function:galactosidase activity" xref: GO:0015926 "molecular_function:glucosidase activity" xref: GO:0015927 "molecular_function:trehalase activity" xref: GO:0015928 "molecular_function:fucosidase activity" xref: GO:0015929 "molecular_function:hexosaminidase activity" xref: GO:0016160 "molecular_function:amylase activity" xref: GO:0044653 "molecular_function:dextrin alpha-glucosidase activity" xref: GO:0044654 "molecular_function:starch alpha-glucosidase activity" xref: GO:0052736 "molecular_function:beta-glucanase activity" xref: GO:0052769 "molecular_function:beta-6-sulfate-N-acetylglucosaminidase activity" xref: GO:0052859 "molecular_function:glucan endo-1,4-beta-glucosidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00167 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP-alpha-D-glucuronate relationship: has_input_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00015 {cardinality="1", is_alternate="False", is_primary="False"} ! UDP relationship: has_output_compound UPa:UPC00191 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucuronate relationship: has_output_compound UPa:UPC00191 ! D-glucuronate relationship: part_of UPa:ULS00465 {cardinality="1", order="1"} ! L-ascorbate from UDP-alpha-D-glucuronate relationship: part_of UPa:ULS00465 ! L-ascorbate from UDP-alpha-D-glucuronate [Term] id: UPa:UER00937 name: L-ascorbate from UDP-alpha-D-glucuronate: step 2/4 namespace: enzymatic_reaction def: "1 D-glucuronate + 1 H(+) + 1 NADPH => 1 L-gulonate + 1 NADP(+)." [] xref: EC:1.1.1.19 xref: GO:0047939 "molecular_function:L-glucuronate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00191 ! D-glucuronate relationship: has_input_compound UPa:UPC00191 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucuronate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00800 {cardinality="1", is_alternate="False", is_primary="True"} ! L-gulonate relationship: has_output_compound UPa:UPC00800 ! L-gulonate relationship: part_of UPa:ULS00465 {cardinality="1", order="2"} ! L-ascorbate from UDP-alpha-D-glucuronate relationship: part_of UPa:ULS00465 ! L-ascorbate from UDP-alpha-D-glucuronate [Term] id: UPa:UER00938 name: L-ascorbate from UDP-alpha-D-glucuronate: step 3/4 namespace: enzymatic_reaction def: "1 L-gulonate => 1 H(2)O + 1 L-gulono-1,4-lactone." [] xref: EC:3.1.1 xref: GO:0004620 "molecular_function:phospholipase activity" xref: GO:0010296 "molecular_function:prenylcysteine methylesterase activity" xref: GO:0016298 "molecular_function:lipase activity" xref: GO:0018731 "molecular_function:1-oxa-2-oxocycloheptane lactonase activity" xref: GO:0018732 "molecular_function:sulfolactone hydrolase activity" xref: GO:0018733 "molecular_function:3,4-dihydrocoumarin hydrolase activity" xref: GO:0018734 "molecular_function:butyrolactone hydrolase activity" xref: GO:0034892 "molecular_function:endosulfan lactone lactonase activity" xref: GO:0035460 "molecular_function:L-ascorbate 6-phosphate lactonase activity" xref: GO:0043905 "molecular_function:Ser-tRNA(Thr) hydrolase activity" xref: GO:0043906 "molecular_function:Ala-tRNA(Pro) hydrolase activity" xref: GO:0043907 "molecular_function:Cys-tRNA(Pro) hydrolase activity" xref: GO:0043908 "molecular_function:Ser(Gly)-tRNA(Ala) hydrolase activity" xref: GO:0047376 "molecular_function:all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity" xref: GO:0050253 "molecular_function:retinyl-palmitate esterase activity" xref: GO:0052689 "molecular_function:carboxylic ester hydrolase activity" xref: GO:0052767 "molecular_function:mannosyl-oligosaccharide 1,6-alpha-mannosidase activity" xref: GO:0052768 "molecular_function:mannosyl-oligosaccharide 1,3-alpha-mannosidase activity" xref: GO:0080030 "molecular_function:methyl indole-3-acetate esterase activity" xref: GO:0080031 "molecular_function:methyl salicylate esterase activity" xref: GO:0080032 "molecular_function:methyl jasmonate esterase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00800 ! L-gulonate relationship: has_input_compound UPa:UPC00800 {cardinality="1", is_alternate="False", is_primary="True"} ! L-gulonate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC01040 ! L-gulono-1,4-lactone relationship: has_output_compound UPa:UPC01040 {cardinality="1", is_alternate="False", is_primary="True"} ! L-gulono-1,4-lactone relationship: part_of UPa:ULS00465 ! L-ascorbate from UDP-alpha-D-glucuronate relationship: part_of UPa:ULS00465 {cardinality="1", order="3"} ! L-ascorbate from UDP-alpha-D-glucuronate [Term] id: UPa:UER00939 name: L-ascorbate from UDP-alpha-D-glucuronate: step 4/4 namespace: enzymatic_reaction def: "1 L-gulono-1,4-lactone + 1 O(2) => 1 H(2)O(2) + 1 L-ascorbate." [] xref: EC:1.1.3.8 xref: GO:0050105 "molecular_function:L-gulonolactone oxidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC01040 ! L-gulono-1,4-lactone relationship: has_input_compound UPa:UPC01040 {cardinality="1", is_alternate="False", is_primary="True"} ! L-gulono-1,4-lactone relationship: has_output_compound UPa:UPC00027 ! H(2)O(2) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00072 ! L-ascorbate relationship: has_output_compound UPa:UPC00072 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ascorbate relationship: part_of UPa:ULS00465 ! L-ascorbate from UDP-alpha-D-glucuronate relationship: part_of UPa:ULS00465 {cardinality="1", order="4"} ! L-ascorbate from UDP-alpha-D-glucuronate [Term] id: UPa:UER00940 name: phosphatidylcholine from choline: step 1/1 namespace: enzymatic_reaction def: "1 CDP-diacylglycerol + 1 choline => 1 CMP + 1 phosphatidylcholine." [] xref: EC:2.7.8.24 xref: GO:0050520 "molecular_function:phosphatidylcholine synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00114 {cardinality="1", is_alternate="False", is_primary="True"} ! choline relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: has_input_compound UPa:UPC00269 {cardinality="1", is_alternate="False", is_primary="False"} ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="False"} ! CMP relationship: has_output_compound UPa:UPC00055 ! CMP relationship: has_output_compound UPa:UPC00157 ! phosphatidylcholine relationship: has_output_compound UPa:UPC00157 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphatidylcholine relationship: part_of UPa:ULS00466 ! phosphatidylcholine from choline relationship: part_of UPa:ULS00466 {cardinality="1", order="1"} ! phosphatidylcholine from choline [Term] id: UPa:UER00941 name: putrescine from N-carbamoylputrescine (transferase route): step 1/1 namespace: enzymatic_reaction def: "1 N-carbamoylputrescine + 1 phosphate => 1 carbamoyl phosphate + 1 putrescine." [] xref: EC:2.1.3.6 xref: GO:0050231 "molecular_function:putrescine carbamoyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00436 ! N-carbamoylputrescine relationship: has_input_compound UPa:UPC00436 {cardinality="1", is_alternate="False", is_primary="True"} ! N-carbamoylputrescine relationship: has_output_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: has_output_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="False"} ! carbamoyl phosphate relationship: part_of UPa:ULS00469 ! putrescine from N-carbamoylputrescine (transferase route) relationship: part_of UPa:ULS00469 {cardinality="1", order="1"} ! putrescine from N-carbamoylputrescine (transferase route) [Term] id: UPa:UER00942 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2 namespace: enzymatic_reaction def: "1 5-amino-1-(5-phospho-D-ribosyl)imidazole + 1 ATP + 1 bicarbonate => 1 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + 1 ADP + 1 phosphate." [] xref: EC:6.3.4.18 xref: GO:0034028 "molecular_function:5-(carboxyamino)imidazole ribonucleotide synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00288 {cardinality="1", is_alternate="False", is_primary="False"} ! bicarbonate relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_input_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_input_compound UPa:UPC03373 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC15667 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC15667 ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:ULS00472 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route) relationship: part_of UPa:ULS00472 {cardinality="1", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route) [Term] id: UPa:UER00943 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2 namespace: enzymatic_reaction def: "1 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole => 1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate." [] xref: EC:5.4.99.18 xref: GO:0034023 "molecular_function:5-(carboxyamino)imidazole ribonucleotide mutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC15667 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole relationship: has_input_compound UPa:UPC15667 ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC04751 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_output_compound UPa:UPC04751 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: part_of UPa:ULS00472 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route) relationship: part_of UPa:ULS00472 {cardinality="1", order="2"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route) [Term] id: UPa:UER00944 name: 7,8-diaminononanoate from 8-amino-7-oxononanoate (Lys route): step 1/1 namespace: enzymatic_reaction def: "1 8-amino-7-oxononanoate + 1 L-lysine => 1 7,8-diaminononanoate + 1 L-2-aminoadipate 6-semialdahyde." [] xref: EC:2.6.1.105 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00047 {cardinality="1", is_alternate="False", is_primary="False"} ! L-lysine relationship: has_input_compound UPa:UPC00047 ! L-lysine relationship: has_input_compound UPa:UPC01092 ! 8-amino-7-oxononanoate relationship: has_input_compound UPa:UPC01092 {cardinality="1", is_alternate="False", is_primary="True"} ! 8-amino-7-oxononanoate relationship: has_output_compound UPa:UPC01037 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC01037 ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC04076 {cardinality="1", is_alternate="False", is_primary="False"} ! L-2-aminoadipate 6-semialdahyde relationship: part_of UPa:ULS00476 ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (Lys route) relationship: part_of UPa:ULS00476 {cardinality="1", order="1"} ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (Lys route) [Term] id: UPa:UER00945 name: orotate from (S)-dihydroorotate (NAD(+) route): step 1/1 namespace: enzymatic_reaction def: "1 (S)-dihydroorotate + 1 NAD(+) => 1 H(+) + 1 NADH + 1 orotate." [] xref: EC:1.3.1.14 xref: GO:0004589 "molecular_function:orotate reductase (NADH) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00337 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00295 {cardinality="1", is_alternate="False", is_primary="True"} ! orotate relationship: has_output_compound UPa:UPC00295 ! orotate relationship: part_of UPa:ULS00480 ! orotate from (S)-dihydroorotate (NAD(+) route) relationship: part_of UPa:ULS00480 {cardinality="1", order="1"} ! orotate from (S)-dihydroorotate (NAD(+) route) [Term] id: UPa:UER00946 name: orotate from (S)-dihydroorotate (quinone route): step 1/1 namespace: enzymatic_reaction def: "1 (S)-dihydroorotate + 1 Quinone => 1 Hydroquinone + 1 orotate." [] xref: EC:1.3.5.2 xref: GO:0004152 "molecular_function:dihydroorotate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00337 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC15602 {cardinality="1", is_alternate="False", is_primary="False"} ! Quinone relationship: has_input_compound UPa:UPC15602 ! Quinone relationship: has_output_compound UPa:UPC00295 {cardinality="1", is_alternate="False", is_primary="True"} ! orotate relationship: has_output_compound UPa:UPC00295 ! orotate relationship: has_output_compound UPa:UPC15603 {cardinality="1", is_alternate="False", is_primary="False"} ! Hydroquinone relationship: has_output_compound UPa:UPC15603 ! Hydroquinone relationship: part_of UPa:ULS00481 ! orotate from (S)-dihydroorotate (quinone route) relationship: part_of UPa:ULS00481 {cardinality="1", order="1"} ! orotate from (S)-dihydroorotate (quinone route) [Term] id: UPa:UER00949 name: None namespace: enzymatic_reaction def: "1 H(+) + 1 L-aspartate 4-semialdehyde + 1 NADH => 1 L-homoserine + 1 NAD(+)." [] xref: EC:1.1.1.3 xref: GO:0004412 "molecular_function:homoserine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00263 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homoserine relationship: has_output_compound UPa:UPC00263 ! L-homoserine relationship: part_of UPa:UER00063 ! L-threonine from L-aspartate: step 3/5 relationship: part_of UPa:UER00465 ! L-homoserine from L-aspartate: step 3/3 [Term] id: UPa:UER00950 name: None namespace: enzymatic_reaction def: "1 H(+) + 1 L-aspartate 4-semialdehyde + 1 NADPH => 1 L-homoserine + 1 NADP(+)." [] xref: EC:1.1.1.3 xref: GO:0004412 "molecular_function:homoserine dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00263 ! L-homoserine relationship: has_output_compound UPa:UPC00263 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homoserine relationship: part_of UPa:UER00063 ! L-threonine from L-aspartate: step 3/5 relationship: part_of UPa:UER00465 ! L-homoserine from L-aspartate: step 3/3 [Term] id: UPa:UER00951 name: None namespace: enzymatic_reaction def: "1 3-oxopropanoate + 1 CoA + 1 NAD(+) => 1 CO(2) + 1 H(+) + 1 NADH + 1 acetyl-CoA." [] xref: EC:1.2.1.18 xref: EC:1.2.1.27 xref: GO:0004491 "molecular_function:methylmalonate-semialdehyde dehydrogenase (acylating) activity" xref: GO:0018478 "molecular_function:malonate-semialdehyde dehydrogenase (acetylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00222 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxopropanoate relationship: has_input_compound UPa:UPC00222 ! 3-oxopropanoate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: part_of UPa:UER00148 ! acetyl-CoA from myo-inositol: step 7/7 [Term] id: UPa:UER00952 name: None namespace: enzymatic_reaction def: "1 3-oxopropanoate + 1 CoA + 1 NADP(+) => 1 CO(2) + 1 H(+) + 1 NADPH + 1 acetyl-CoA." [] xref: EC:1.2.1.18 xref: EC:1.2.1.27 xref: GO:0004491 "molecular_function:methylmalonate-semialdehyde dehydrogenase (acylating) activity" xref: GO:0018478 "molecular_function:malonate-semialdehyde dehydrogenase (acetylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00222 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxopropanoate relationship: has_input_compound UPa:UPC00222 ! 3-oxopropanoate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: part_of UPa:UER00148 ! acetyl-CoA from myo-inositol: step 7/7 [Term] id: UPa:UER00953 name: None namespace: enzymatic_reaction def: "1 ATP + 1 adenosylcobinamide => 1 ADP + 1 adenosylcobinamide phosphate." [] xref: EC:2.7.1.156 xref: GO:0043752 "molecular_function:adenosylcobinamide kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="True", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC06508 ! adenosylcobinamide relationship: has_input_compound UPa:UPC06508 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="True", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC06509 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide phosphate relationship: has_output_compound UPa:UPC06509 ! adenosylcobinamide phosphate relationship: part_of UPa:UER00236 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7 [Term] id: UPa:UER00954 name: None namespace: enzymatic_reaction def: "1 GTP + 1 adenosylcobinamide => 1 GDP + 1 adenosylcobinamide phosphate." [] xref: EC:2.7.1.156 xref: GO:0043752 "molecular_function:adenosylcobinamide kinase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_input_compound UPa:UPC00044 {cardinality="1", is_alternate="True", is_primary="False"} ! GTP relationship: has_input_compound UPa:UPC06508 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide relationship: has_input_compound UPa:UPC06508 ! adenosylcobinamide relationship: has_output_compound UPa:UPC00035 ! GDP relationship: has_output_compound UPa:UPC00035 {cardinality="1", is_alternate="True", is_primary="False"} ! GDP relationship: has_output_compound UPa:UPC06509 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide phosphate relationship: has_output_compound UPa:UPC06509 ! adenosylcobinamide phosphate relationship: part_of UPa:UER00236 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7 [Term] id: UPa:UER00955 name: None namespace: enzymatic_reaction def: "1 3,4-dihydroxybenzoate + 1 H(+) + 1 NADH + 1 O(2) => 1 CO(2) + 1 H(2)O + 1 NAD(+) + 1 benzene-1,2,4-triol." [] xref: EC:1.13.11 xref: GO:0016702 "molecular_function:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" xref: GO:0018542 "molecular_function:2,3-dihydroxy DDT 1,2-dioxygenase activity" xref: GO:0018555 "molecular_function:phenanthrene dioxygenase activity" xref: GO:0018556 "molecular_function:2,2',3-trihydroxybiphenyl dioxygenase activity" xref: GO:0018557 "molecular_function:1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity" xref: GO:0018558 "molecular_function:5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity" xref: GO:0018559 "molecular_function:1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity" xref: GO:0018560 "molecular_function:protocatechuate 3,4-dioxygenase type II activity" xref: GO:0018561 "molecular_function:2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity" xref: GO:0018562 "molecular_function:3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity" xref: GO:0018563 "molecular_function:2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity" xref: GO:0018564 "molecular_function:carbazole 1,9a-dioxygenase activity" xref: GO:0018565 "molecular_function:dihydroxydibenzothiophene dioxygenase activity" xref: GO:0018566 "molecular_function:1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity" xref: GO:0018567 "molecular_function:styrene dioxygenase activity" xref: GO:0018568 "molecular_function:3,4-dihydroxyphenanthrene dioxygenase activity" xref: GO:0018569 "molecular_function:hydroquinone 1,2-dioxygenase activity" xref: GO:0018570 "molecular_function:p-cumate 2,3-dioxygenase activity" xref: GO:0018571 "molecular_function:2,3-dihydroxy-p-cumate dioxygenase activity" xref: GO:0018572 "molecular_function:3,5-dichlorocatechol 1,2-dioxygenase activity" xref: GO:0018573 "molecular_function:2-aminophenol 1,6-dioxygenase activity" xref: GO:0018574 "molecular_function:2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity" xref: GO:0018575 "molecular_function:chlorocatechol 1,2-dioxygenase activity" xref: GO:0019114 "molecular_function:catechol dioxygenase activity" xref: GO:0019117 "molecular_function:dihydroxyfluorene dioxygenase activity" xref: GO:0034543 "molecular_function:5-aminosalicylate dioxygenase activity" xref: GO:0034803 "molecular_function:3-hydroxy-2-naphthoate 2,3-dioxygenase activity" xref: GO:0034806 "molecular_function:benzo(a)pyrene 11,12-dioxygenase activity" xref: GO:0034808 "molecular_function:benzo(a)pyrene 4,5-dioxygenase activity" xref: GO:0034810 "molecular_function:4,5-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034811 "molecular_function:benzo(a)pyrene 9,10-dioxygenase activity" xref: GO:0034812 "molecular_function:9,10-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034813 "molecular_function:benzo(a)pyrene 7,8-dioxygenase activity" xref: GO:0034814 "molecular_function:7,8-dihydroxy benzo(a)pyrene dioxygenase activity" xref: GO:0034827 "molecular_function:1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity" xref: GO:0034834 "molecular_function:2-mercaptobenzothiazole dioxygenase activity" xref: GO:0034895 "molecular_function:pyridine-3,4-diol dioxygenase activity" xref: GO:0034920 "molecular_function:pyrene dioxygenase activity" xref: GO:0034922 "molecular_function:4,5-dihydroxypyrene dioxygenase activity" xref: GO:0034934 "molecular_function:phenanthrene-4-carboxylate dioxygenase activity" xref: GO:0034935 "molecular_function:tetrachlorobenzene dioxygenase activity" xref: GO:0034936 "molecular_function:4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity" xref: GO:0034955 "molecular_function:2,3-dihydroxydiphenyl ether dioxygenase activity" xref: GO:0034956 "molecular_function:diphenyl ether 1,2-dioxygenase activity" xref: GO:0036403 "molecular_function:arachidonate 8(S)-lipoxygenase activity" xref: GO:0047074 "molecular_function:4-hydroxycatechol 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00230 {cardinality="1", is_alternate="False", is_primary="True"} ! 3,4-dihydroxybenzoate relationship: has_input_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC02814 {cardinality="1", is_alternate="False", is_primary="True"} ! benzene-1,2,4-triol relationship: has_output_compound UPa:UPC02814 ! benzene-1,2,4-triol relationship: part_of UPa:UER00267 ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 1/4 [Term] id: UPa:UER00956 name: None namespace: enzymatic_reaction def: "1 3,4-dihydroxybenzoate + 1 H(+) + 1 NADPH + 1 O(2) => 1 CO(2) + 1 H(2)O + 1 NADP(+) + 1 benzene-1,2,4-triol." [] xref: EC:1.13.11 xref: GO:0016702 "molecular_function:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" xref: GO:0018542 "molecular_function:2,3-dihydroxy DDT 1,2-dioxygenase activity" xref: GO:0018555 "molecular_function:phenanthrene dioxygenase activity" xref: GO:0018556 "molecular_function:2,2',3-trihydroxybiphenyl dioxygenase activity" xref: GO:0018557 "molecular_function:1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity" xref: GO:0018558 "molecular_function:5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity" xref: GO:0018559 "molecular_function:1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity" xref: GO:0018560 "molecular_function:protocatechuate 3,4-dioxygenase type II activity" xref: GO:0018561 "molecular_function:2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity" xref: GO:0018562 "molecular_function:3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity" xref: GO:0018563 "molecular_function:2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity" xref: GO:0018564 "molecular_function:carbazole 1,9a-dioxygenase activity" xref: GO:0018565 "molecular_function:dihydroxydibenzothiophene dioxygenase activity" xref: GO:0018566 "molecular_function:1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity" xref: GO:0018567 "molecular_function:styrene dioxygenase activity" xref: GO:0018568 "molecular_function:3,4-dihydroxyphenanthrene dioxygenase activity" xref: GO:0018569 "molecular_function:hydroquinone 1,2-dioxygenase activity" xref: GO:0018570 "molecular_function:p-cumate 2,3-dioxygenase activity" xref: GO:0018571 "molecular_function:2,3-dihydroxy-p-cumate dioxygenase activity" xref: GO:0018572 "molecular_function:3,5-dichlorocatechol 1,2-dioxygenase activity" xref: GO:0018573 "molecular_function:2-aminophenol 1,6-dioxygenase activity" xref: GO:0018574 "molecular_function:2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity" xref: GO:0018575 "molecular_function:chlorocatechol 1,2-dioxygenase activity" xref: GO:0019114 "molecular_function:catechol dioxygenase activity" xref: GO:0019117 "molecular_function:dihydroxyfluorene dioxygenase activity" xref: GO:0034543 "molecular_function:5-aminosalicylate dioxygenase activity" xref: GO:0034803 "molecular_function:3-hydroxy-2-naphthoate 2,3-dioxygenase activity" xref: GO:0034806 "molecular_function:benzo(a)pyrene 11,12-dioxygenase activity" xref: GO:0034808 "molecular_function:benzo(a)pyrene 4,5-dioxygenase activity" xref: GO:0034810 "molecular_function:4,5-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034811 "molecular_function:benzo(a)pyrene 9,10-dioxygenase activity" xref: GO:0034812 "molecular_function:9,10-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034813 "molecular_function:benzo(a)pyrene 7,8-dioxygenase activity" xref: GO:0034814 "molecular_function:7,8-dihydroxy benzo(a)pyrene dioxygenase activity" xref: GO:0034827 "molecular_function:1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity" xref: GO:0034834 "molecular_function:2-mercaptobenzothiazole dioxygenase activity" xref: GO:0034895 "molecular_function:pyridine-3,4-diol dioxygenase activity" xref: GO:0034920 "molecular_function:pyrene dioxygenase activity" xref: GO:0034922 "molecular_function:4,5-dihydroxypyrene dioxygenase activity" xref: GO:0034934 "molecular_function:phenanthrene-4-carboxylate dioxygenase activity" xref: GO:0034935 "molecular_function:tetrachlorobenzene dioxygenase activity" xref: GO:0034936 "molecular_function:4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity" xref: GO:0034955 "molecular_function:2,3-dihydroxydiphenyl ether dioxygenase activity" xref: GO:0034956 "molecular_function:diphenyl ether 1,2-dioxygenase activity" xref: GO:0036403 "molecular_function:arachidonate 8(S)-lipoxygenase activity" xref: GO:0047074 "molecular_function:4-hydroxycatechol 1,2-dioxygenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00230 {cardinality="1", is_alternate="False", is_primary="True"} ! 3,4-dihydroxybenzoate relationship: has_input_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC02814 {cardinality="1", is_alternate="False", is_primary="True"} ! benzene-1,2,4-triol relationship: has_output_compound UPa:UPC02814 ! benzene-1,2,4-triol relationship: part_of UPa:UER00267 ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 1/4 [Term] id: UPa:UER00957 name: None namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 maleylacetate => 1 3-oxoadipate + 1 NAD(+)." [] xref: EC:1.3.1.32 xref: GO:0018506 "molecular_function:maleylacetate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC02222 {cardinality="1", is_alternate="False", is_primary="True"} ! maleylacetate relationship: has_input_compound UPa:UPC02222 ! maleylacetate relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00846 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxoadipate relationship: has_output_compound UPa:UPC00846 ! 3-oxoadipate relationship: part_of UPa:UER00278 ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 4/4 [Term] id: UPa:UER00958 name: None namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 maleylacetate => 1 3-oxoadipate + 1 NADP(+)." [] xref: EC:1.3.1.32 xref: GO:0018506 "molecular_function:maleylacetate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC02222 ! maleylacetate relationship: has_input_compound UPa:UPC02222 {cardinality="1", is_alternate="False", is_primary="True"} ! maleylacetate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00846 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxoadipate relationship: has_output_compound UPa:UPC00846 ! 3-oxoadipate relationship: part_of UPa:UER00278 ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 4/4 [Term] id: UPa:UER00959 name: L-tyrosine from L-arogenate (NAD(+) route): step 1/1 namespace: enzymatic_reaction def: "1 L-arogenate + 1 NAD(+) => 1 CO(2) + 1 H(+) + 1 L-tyrosine + 1 NADH." [] xref: EC:1.3.1.43 xref: GO:0047794 "molecular_function:cyclohexadienyl dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00826 ! L-arogenate relationship: has_input_compound UPa:UPC00826 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arogenate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC00082 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tyrosine relationship: part_of UPa:ULS00486 ! L-tyrosine from L-arogenate (NAD(+) route) relationship: part_of UPa:ULS00486 {cardinality="1", order="1"} ! L-tyrosine from L-arogenate (NAD(+) route) [Term] id: UPa:UER00960 name: L-tyrosine from L-arogenate (NADP(+) route): step 1/1 namespace: enzymatic_reaction def: "1 L-arogenate + 1 NADP(+) => 1 CO(2) + 1 H(+) + 1 L-tyrosine + 1 NADPH." [] xref: EC:1.3.1.78 xref: GO:0033730 "molecular_function:arogenate dehydrogenase (NADP+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00826 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arogenate relationship: has_input_compound UPa:UPC00826 ! L-arogenate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00082 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tyrosine relationship: has_output_compound UPa:UPC00082 ! L-tyrosine relationship: part_of UPa:ULS00487 ! L-tyrosine from L-arogenate (NADP(+) route) relationship: part_of UPa:ULS00487 {cardinality="1", order="1"} ! L-tyrosine from L-arogenate (NADP(+) route) [Term] id: UPa:UER00961 name: (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1 namespace: enzymatic_reaction def: "1 NAD(+) + 1 prephenate => 1 (4-hydroxyphenyl)pyruvate + 1 CO(2) + 1 H(+) + 1 NADH." [] xref: EC:1.3.1.12 xref: GO:0008977 "molecular_function:prephenate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_input_compound UPa:UPC00254 {cardinality="1", is_alternate="False", is_primary="True"} ! prephenate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC01179 {cardinality="1", is_alternate="False", is_primary="True"} ! (4-hydroxyphenyl)pyruvate relationship: part_of UPa:ULS00483 ! (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route) relationship: part_of UPa:ULS00483 {cardinality="1", order="1"} ! (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route) [Term] id: UPa:UER00962 name: (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1 namespace: enzymatic_reaction def: "1 NADP(+) + 1 prephenate => 1 (4-hydroxyphenyl)pyruvate + 1 CO(2) + 1 H(+) + 1 NADPH." [] xref: EC:1.3.1.13 xref: GO:0004665 "molecular_function:prephenate dehydrogenase (NADP+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_input_compound UPa:UPC00254 {cardinality="1", is_alternate="False", is_primary="True"} ! prephenate relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC01179 {cardinality="1", is_alternate="False", is_primary="True"} ! (4-hydroxyphenyl)pyruvate relationship: part_of UPa:ULS00484 ! (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route) relationship: part_of UPa:ULS00484 {cardinality="1", order="1"} ! (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route) [Term] id: UPa:UER00963 name: None namespace: enzymatic_reaction def: "1 L-aspartate + 1 NAD(+) => 1 H(+) + 1 NADH + 1 iminoaspartate." [] xref: EC:1.4.1.21 xref: GO:0033735 "molecular_function:aspartate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC05840 {cardinality="1", is_alternate="False", is_primary="True"} ! iminoaspartate relationship: has_output_compound UPa:UPC05840 ! iminoaspartate relationship: part_of UPa:UER00456 ! iminoaspartate from L-aspartate (dehydrogenase route): step 1/1 [Term] id: UPa:UER00964 name: None namespace: enzymatic_reaction def: "1 L-aspartate + 1 NADP(+) => 1 H(+) + 1 NADPH + 1 iminoaspartate." [] xref: EC:1.4.1.21 xref: GO:0033735 "molecular_function:aspartate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC05840 {cardinality="1", is_alternate="False", is_primary="True"} ! iminoaspartate relationship: has_output_compound UPa:UPC05840 ! iminoaspartate relationship: part_of UPa:UER00456 ! iminoaspartate from L-aspartate (dehydrogenase route): step 1/1 [Term] id: UPa:UER00967 name: None namespace: enzymatic_reaction def: "1 CDP-4-dehydro-6-deoxy-D-glucose + 1 H(+) + 1 NADH => 1 CDP-4-dehydro-3,6-dideoxy-D-glucose + 1 H(2)O + 1 NAD(+)." [] xref: EC:1.17.1.1 xref: GO:0047099 "molecular_function:CDP-4-dehydro-6-deoxyglucose reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01219 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-4-dehydro-6-deoxy-D-glucose relationship: has_input_compound UPa:UPC01219 ! CDP-4-dehydro-6-deoxy-D-glucose relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC04297 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC04297 ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: part_of UPa:UER00513 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 3/5 [Term] id: UPa:UER00968 name: None namespace: enzymatic_reaction def: "1 CDP-4-dehydro-6-deoxy-D-glucose + 1 H(+) + 1 NADPH => 1 CDP-4-dehydro-3,6-dideoxy-D-glucose + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.17.1.1 xref: GO:0047099 "molecular_function:CDP-4-dehydro-6-deoxyglucose reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01219 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-4-dehydro-6-deoxy-D-glucose relationship: has_input_compound UPa:UPC01219 ! CDP-4-dehydro-6-deoxy-D-glucose relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC04297 ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC04297 {cardinality="1", is_alternate="False", is_primary="True"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: part_of UPa:UER00513 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 3/5 [Term] id: UPa:UER00969 name: None namespace: enzymatic_reaction def: "1 H(+) + 1 L-arabinose + 1 NADH => 1 L-arabinitol + 1 NAD(+)." [] xref: EC:1.1.1.21 xref: GO:0004032 "molecular_function:alditol:NADP+ 1-oxidoreductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00259 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinose relationship: has_input_compound UPa:UPC00259 ! L-arabinose relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00532 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinitol relationship: has_output_compound UPa:UPC00532 ! L-arabinitol relationship: part_of UPa:UER00574 ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 1/5 [Term] id: UPa:UER00970 name: None namespace: enzymatic_reaction def: "1 H(+) + 1 L-arabinose + 1 NADPH => 1 L-arabinitol + 1 NADP(+)." [] xref: EC:1.1.1.21 xref: GO:0004032 "molecular_function:alditol:NADP+ 1-oxidoreductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00259 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinose relationship: has_input_compound UPa:UPC00259 ! L-arabinose relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00532 ! L-arabinitol relationship: has_output_compound UPa:UPC00532 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arabinitol relationship: part_of UPa:UER00574 ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 1/5 [Term] id: UPa:UER00971 name: None namespace: enzymatic_reaction def: "1 NAD(+) + 1 S-(hydroxymethyl)glutathione => 1 H(+) + 1 NADH + 1 S-formylglutathione." [] xref: EC:1.1.1.284 xref: GO:0051903 "molecular_function:S-(hydroxymethyl)glutathione dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC14180 {cardinality="1", is_alternate="False", is_primary="True"} ! S-(hydroxymethyl)glutathione relationship: has_input_compound UPa:UPC14180 ! S-(hydroxymethyl)glutathione relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC01031 ! S-formylglutathione relationship: has_output_compound UPa:UPC01031 {cardinality="1", is_alternate="False", is_primary="True"} ! S-formylglutathione relationship: part_of UPa:UER00622 ! formate from formaldehyde (glutathione route): step 2/3 [Term] id: UPa:UER00972 name: None namespace: enzymatic_reaction def: "1 NADP(+) + 1 S-(hydroxymethyl)glutathione => 1 H(+) + 1 NADPH + 1 S-formylglutathione." [] xref: EC:1.1.1.284 xref: GO:0051903 "molecular_function:S-(hydroxymethyl)glutathione dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC14180 {cardinality="1", is_alternate="False", is_primary="True"} ! S-(hydroxymethyl)glutathione relationship: has_input_compound UPa:UPC14180 ! S-(hydroxymethyl)glutathione relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC01031 ! S-formylglutathione relationship: has_output_compound UPa:UPC01031 {cardinality="1", is_alternate="False", is_primary="True"} ! S-formylglutathione relationship: part_of UPa:UER00622 ! formate from formaldehyde (glutathione route): step 2/3 [Term] id: UPa:UER00973 name: None namespace: enzymatic_reaction def: "1 2-hydroxy-3-oxopropanoate + 1 H(+) + 1 NADH => 1 D-glycerate + 1 NAD(+)." [] xref: EC:1.1.1.60 xref: GO:0008679 "molecular_function:2-hydroxy-3-oxopropionate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01146 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxopropanoate relationship: has_input_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: part_of UPa:UER00631 ! D-glycerate from galactarate: step 3/3 relationship: part_of UPa:UER00832 ! 3-phospho-D-glycerate from glycolate: step 3/4 [Term] id: UPa:UER00974 name: None namespace: enzymatic_reaction def: "1 2-hydroxy-3-oxopropanoate + 1 H(+) + 1 NADPH => 1 D-glycerate + 1 NADP(+)." [] xref: EC:1.1.1.60 xref: GO:0008679 "molecular_function:2-hydroxy-3-oxopropionate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC01146 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxopropanoate relationship: has_input_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: part_of UPa:UER00631 ! D-glycerate from galactarate: step 3/3 relationship: part_of UPa:UER00832 ! 3-phospho-D-glycerate from glycolate: step 3/4 [Term] id: UPa:UER00975 name: None namespace: enzymatic_reaction def: "1 (S)-ureidoglycolate + 1 NAD(+) => 1 H(+) + 1 NADH + 1 oxalurate." [] xref: EC:1.1.1.154 xref: GO:0009040 "molecular_function:ureidoglycolate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00603 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-ureidoglycolate relationship: has_input_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00802 {cardinality="1", is_alternate="False", is_primary="True"} ! oxalurate relationship: has_output_compound UPa:UPC00802 ! oxalurate relationship: part_of UPa:UER00657 ! oxalurate from (S)-ureidoglycolate: step 1/1 [Term] id: UPa:UER00976 name: None namespace: enzymatic_reaction def: "1 (S)-ureidoglycolate + 1 NADP(+) => 1 H(+) + 1 NADPH + 1 oxalurate." [] xref: EC:1.1.1.154 xref: GO:0009040 "molecular_function:ureidoglycolate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00603 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-ureidoglycolate relationship: has_input_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00802 {cardinality="1", is_alternate="False", is_primary="True"} ! oxalurate relationship: has_output_compound UPa:UPC00802 ! oxalurate relationship: part_of UPa:UER00657 ! oxalurate from (S)-ureidoglycolate: step 1/1 [Term] id: UPa:UER00977 name: None namespace: enzymatic_reaction def: "1 D-arabinose + 1 NAD(+) => 1 D-arabinono-1,4-lactone + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.116 xref: EC:1.1.1.117 xref: GO:0045290 "molecular_function:D-arabinose 1-dehydrogenase [NAD(P)+] activity" xref: GO:0047816 "molecular_function:D-arabinose 1-dehydrogenase (NAD) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00216 {cardinality="1", is_alternate="False", is_primary="True"} ! D-arabinose relationship: has_input_compound UPa:UPC00216 ! D-arabinose relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00652 {cardinality="1", is_alternate="False", is_primary="True"} ! D-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC00652 ! D-arabinono-1,4-lactone relationship: part_of UPa:UER00765 ! dehydro-D-arabinono-1,4-lactone from D-arabinose: step 1/2 [Term] id: UPa:UER00978 name: None namespace: enzymatic_reaction def: "1 D-arabinose + 1 NADP(+) => 1 D-arabinono-1,4-lactone + 1 H(+) + 1 NADPH." [] xref: EC:1.1.1.116 xref: EC:1.1.1.117 xref: GO:0045290 "molecular_function:D-arabinose 1-dehydrogenase [NAD(P)+] activity" xref: GO:0047816 "molecular_function:D-arabinose 1-dehydrogenase (NAD) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00216 {cardinality="1", is_alternate="False", is_primary="True"} ! D-arabinose relationship: has_input_compound UPa:UPC00216 ! D-arabinose relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00652 {cardinality="1", is_alternate="False", is_primary="True"} ! D-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC00652 ! D-arabinono-1,4-lactone relationship: part_of UPa:UER00765 ! dehydro-D-arabinono-1,4-lactone from D-arabinose: step 1/2 [Term] id: UPa:UER00981 name: None namespace: enzymatic_reaction def: "1 2-hydroxy-3-oxosuccinate + 1 H(+) + 1 NADH => 1 CO(2) + 1 D-glycerate + 1 NAD(+)." [] xref: EC:1.1.1.92 xref: GO:0047047 "molecular_function:oxaloglycolate reductase (decarboxylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC03459 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxosuccinate relationship: has_input_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: has_output_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: part_of UPa:UER00802 ! D-glycerate from 2-hydroxy-3-oxosuccinate: step 1/1 [Term] id: UPa:UER00982 name: None namespace: enzymatic_reaction def: "1 2-hydroxy-3-oxosuccinate + 1 H(+) + 1 NADPH => 1 CO(2) + 1 D-glycerate + 1 NADP(+)." [] xref: EC:1.1.1.92 xref: GO:0047047 "molecular_function:oxaloglycolate reductase (decarboxylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC03459 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-3-oxosuccinate relationship: has_input_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: has_output_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: part_of UPa:UER00802 ! D-glycerate from 2-hydroxy-3-oxosuccinate: step 1/1 [Term] id: UPa:UER00983 name: None namespace: enzymatic_reaction def: "1 D-glycerate + 1 NAD(+) => 1 3-hydroxypyruvate + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.29 xref: GO:0008465 "molecular_function:glycerate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_input_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00168 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxypyruvate relationship: has_output_compound UPa:UPC00168 ! 3-hydroxypyruvate relationship: part_of UPa:UER00804 ! 3-hydroxypyruvate from D-glycerate: step 1/1 [Term] id: UPa:UER00984 name: None namespace: enzymatic_reaction def: "1 D-glycerate + 1 NADP(+) => 1 3-hydroxypyruvate + 1 H(+) + 1 NADPH." [] xref: EC:1.1.1.29 xref: EC:1.1.1.81 xref: GO:0008465 "molecular_function:glycerate dehydrogenase activity" xref: GO:0016618 "molecular_function:hydroxypyruvate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_input_compound UPa:UPC00258 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glycerate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00168 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxypyruvate relationship: has_output_compound UPa:UPC00168 ! 3-hydroxypyruvate relationship: part_of UPa:UER00804 ! 3-hydroxypyruvate from D-glycerate: step 1/1 [Term] id: UPa:UER00985 name: None namespace: enzymatic_reaction def: "1 H(2)O + 1 L-2-aminoadipate 6-semialdahyde + 1 NAD(+) => 1 H(+) + 1 L-alpha-aminoadipate + 1 NADH." [] xref: EC:1.2.1.31 xref: GO:0004043 "molecular_function:L-aminoadipate-semialdehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC04076 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-aminoadipate 6-semialdahyde relationship: has_input_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: part_of UPa:UER00837 ! glutaryl-CoA from L-lysine: step 3/6 [Term] id: UPa:UER00986 name: None namespace: enzymatic_reaction def: "1 H(2)O + 1 L-2-aminoadipate 6-semialdahyde + 1 NADP(+) => 1 H(+) + 1 L-alpha-aminoadipate + 1 NADPH." [] xref: EC:1.2.1.31 xref: GO:0004043 "molecular_function:L-aminoadipate-semialdehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC04076 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-aminoadipate 6-semialdahyde relationship: has_input_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: part_of UPa:UER00837 ! glutaryl-CoA from L-lysine: step 3/6 [Term] id: UPa:UER00987 name: None namespace: enzymatic_reaction def: "1 H(2)O + 1 NADP(+) + 1 benzaldehyde => 1 H(+) + 1 NADPH + 1 benzoate." [] xref: EC:1.2.1.7 xref: GO:0018477 "molecular_function:benzaldehyde dehydrogenase (NADP+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00261 ! benzaldehyde relationship: has_input_compound UPa:UPC00261 {cardinality="1", is_alternate="False", is_primary="True"} ! benzaldehyde relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00180 ! benzoate relationship: has_output_compound UPa:UPC00180 {cardinality="1", is_alternate="False", is_primary="True"} ! benzoate relationship: part_of UPa:UER00855 ! benzoate from (R)-mandelate: step 4/4 [Term] id: UPa:UER00988 name: None namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 benzaldehyde => 1 H(+) + 1 NADH + 1 benzoate." [] xref: EC:1.2.1.28 xref: GO:0018479 "molecular_function:benzaldehyde dehydrogenase (NAD+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00261 ! benzaldehyde relationship: has_input_compound UPa:UPC00261 {cardinality="1", is_alternate="False", is_primary="True"} ! benzaldehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00180 ! benzoate relationship: has_output_compound UPa:UPC00180 {cardinality="1", is_alternate="False", is_primary="True"} ! benzoate relationship: part_of UPa:UER00855 ! benzoate from (R)-mandelate: step 4/4 [Term] id: UPa:UER00989 name: None namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 gamma-glutamyl-4-aminobutanal => 1 4-(L-gamma-glutamylamino)butanoic acid + 1 H(+) + 1 NADH." [] xref: EC:1.2.1 xref: GO:0004028 "molecular_function:3-chloroallyl aldehyde dehydrogenase activity" xref: GO:0016620 "molecular_function:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" xref: GO:0018472 "molecular_function:1-hydroxy-2-naphthaldehyde dehydrogenase activity" xref: GO:0018473 "molecular_function:cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity" xref: GO:0018474 "molecular_function:2-carboxybenzaldehyde dehydrogenase activity" xref: GO:0018475 "molecular_function:trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity" xref: GO:0019115 "molecular_function:benzaldehyde dehydrogenase activity" xref: GO:0034520 "molecular_function:2-naphthaldehyde dehydrogenase activity" xref: GO:0034525 "molecular_function:1-naphthaldehyde dehydrogenase activity" xref: GO:0034530 "molecular_function:4-hydroxymethylsalicyaldehyde dehydrogenase activity" xref: GO:0034538 "molecular_function:3-methylsalicylaldehyde dehydrogenase activity" xref: GO:0034601 "molecular_function:oxoglutarate dehydrogenase [NAD(P)+] activity" xref: GO:0034602 "molecular_function:oxoglutarate dehydrogenase (NAD+) activity" xref: GO:0034603 "molecular_function:pyruvate dehydrogenase [NAD(P)+] activity" xref: GO:0034604 "molecular_function:pyruvate dehydrogenase (NAD+) activity" xref: GO:0034822 "molecular_function:citronellal dehydrogenase activity" xref: GO:0034832 "molecular_function:geranial dehydrogenase activity" xref: GO:0043745 "molecular_function:N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity" xref: GO:0043796 "molecular_function:glyceraldehyde dehydrogenase (NADP) activity" xref: GO:0043870 "molecular_function:N-acetyl-gamma-aminoadipyl-phosphate reductase activity" xref: GO:0043878 "molecular_function:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity" xref: GO:0044104 "molecular_function:2,5-dioxovalerate dehydrogenase (NAD+) activity" xref: GO:0052814 "molecular_function:medium-chain-aldehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC15700 {cardinality="1", is_alternate="False", is_primary="True"} ! gamma-glutamyl-4-aminobutanal relationship: has_input_compound UPa:UPC15700 ! gamma-glutamyl-4-aminobutanal relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC15767 ! 4-(L-gamma-glutamylamino)butanoic acid relationship: has_output_compound UPa:UPC15767 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-(L-gamma-glutamylamino)butanoic acid relationship: part_of UPa:UER00882 ! 4-aminobutanoate from putrescine: step 3/4 [Term] id: UPa:UER00990 name: None namespace: enzymatic_reaction def: "1 H(2)O + 1 NADP(+) + 1 gamma-glutamyl-4-aminobutanal => 1 4-(L-gamma-glutamylamino)butanoic acid + 1 H(+) + 1 NADPH." [] xref: EC:1.2.1 xref: GO:0004028 "molecular_function:3-chloroallyl aldehyde dehydrogenase activity" xref: GO:0016620 "molecular_function:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" xref: GO:0018472 "molecular_function:1-hydroxy-2-naphthaldehyde dehydrogenase activity" xref: GO:0018473 "molecular_function:cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity" xref: GO:0018474 "molecular_function:2-carboxybenzaldehyde dehydrogenase activity" xref: GO:0018475 "molecular_function:trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity" xref: GO:0019115 "molecular_function:benzaldehyde dehydrogenase activity" xref: GO:0034520 "molecular_function:2-naphthaldehyde dehydrogenase activity" xref: GO:0034525 "molecular_function:1-naphthaldehyde dehydrogenase activity" xref: GO:0034530 "molecular_function:4-hydroxymethylsalicyaldehyde dehydrogenase activity" xref: GO:0034538 "molecular_function:3-methylsalicylaldehyde dehydrogenase activity" xref: GO:0034601 "molecular_function:oxoglutarate dehydrogenase [NAD(P)+] activity" xref: GO:0034602 "molecular_function:oxoglutarate dehydrogenase (NAD+) activity" xref: GO:0034603 "molecular_function:pyruvate dehydrogenase [NAD(P)+] activity" xref: GO:0034604 "molecular_function:pyruvate dehydrogenase (NAD+) activity" xref: GO:0034822 "molecular_function:citronellal dehydrogenase activity" xref: GO:0034832 "molecular_function:geranial dehydrogenase activity" xref: GO:0043745 "molecular_function:N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity" xref: GO:0043796 "molecular_function:glyceraldehyde dehydrogenase (NADP) activity" xref: GO:0043870 "molecular_function:N-acetyl-gamma-aminoadipyl-phosphate reductase activity" xref: GO:0043878 "molecular_function:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity" xref: GO:0044104 "molecular_function:2,5-dioxovalerate dehydrogenase (NAD+) activity" xref: GO:0052814 "molecular_function:medium-chain-aldehyde dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC15700 ! gamma-glutamyl-4-aminobutanal relationship: has_input_compound UPa:UPC15700 {cardinality="1", is_alternate="False", is_primary="True"} ! gamma-glutamyl-4-aminobutanal relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC15767 ! 4-(L-gamma-glutamylamino)butanoic acid relationship: has_output_compound UPa:UPC15767 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-(L-gamma-glutamylamino)butanoic acid relationship: part_of UPa:UER00882 ! 4-aminobutanoate from putrescine: step 3/4 [Term] id: UPa:UER00993 name: None namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 dihydrobiopterin => 1 NAD(+) + 1 tetrahydrobiopterin." [] xref: EC:1.5.1.34 xref: GO:0004155 "molecular_function:6,7-dihydropteridine reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00268 ! dihydrobiopterin relationship: has_input_compound UPa:UPC00268 {cardinality="1", is_alternate="False", is_primary="True"} ! dihydrobiopterin relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00272 {cardinality="1", is_alternate="False", is_primary="True"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: part_of UPa:UER00856 ! tetrahydrobiopterin from dihydrobiopterin: step 1/1 [Term] id: UPa:UER00994 name: None namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 dihydrobiopterin => 1 NADP(+) + 1 tetrahydrobiopterin." [] xref: EC:1.5.1.34 xref: GO:0004155 "molecular_function:6,7-dihydropteridine reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00268 {cardinality="1", is_alternate="False", is_primary="True"} ! dihydrobiopterin relationship: has_input_compound UPa:UPC00268 ! dihydrobiopterin relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00272 {cardinality="1", is_alternate="False", is_primary="True"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: part_of UPa:UER00856 ! tetrahydrobiopterin from dihydrobiopterin: step 1/1 [Term] id: UPa:UER00995 name: 2-oxoglutarate from isocitrate (NADP(+) route): step 1/1 namespace: enzymatic_reaction def: "1 NADP(+) + 1 isocitrate => 1 2-oxoglutarate + 1 CO(2) + 1 H(+) + 1 NADPH." [] xref: EC:1.1.1.42 xref: GO:0004450 "molecular_function:isocitrate dehydrogenase (NADP+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00311 ! isocitrate relationship: has_input_compound UPa:UPC00311 {cardinality="1", is_alternate="False", is_primary="True"} ! isocitrate relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: part_of UPa:ULS00488 {cardinality="1", order="1"} ! 2-oxoglutarate from isocitrate (NADP(+) route) relationship: part_of UPa:ULS00488 ! 2-oxoglutarate from isocitrate (NADP(+) route) [Term] id: UPa:UER00996 name: 2-oxoglutarate from isocitrate (NAD(+) route): step 1/1 namespace: enzymatic_reaction def: "1 NAD(+) + 1 isocitrate => 1 2-oxoglutarate + 1 CO(2) + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.41 xref: GO:0004449 "molecular_function:isocitrate dehydrogenase (NAD+) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00311 ! isocitrate relationship: has_input_compound UPa:UPC00311 {cardinality="1", is_alternate="False", is_primary="True"} ! isocitrate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: part_of UPa:ULS00489 {cardinality="1", order="1"} ! 2-oxoglutarate from isocitrate (NAD(+) route) relationship: part_of UPa:ULS00489 ! 2-oxoglutarate from isocitrate (NAD(+) route) [Term] id: UPa:UER00997 name: succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 CoA + 1 NAD(+) => 1 CO(2) + 1 H(+) + 1 NADH + 1 succinyl-CoA." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="True"} ! succinyl-CoA relationship: part_of UPa:ULS00490 {cardinality="1", order="1"} ! succinyl-CoA from 2-oxoglutarate (dehydrogenase route) relationship: part_of UPa:ULS00490 ! succinyl-CoA from 2-oxoglutarate (dehydrogenase route) [Term] id: UPa:UER00998 name: succinyl-CoA from 2-oxoglutarate (synthase route): step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 CoA + 2 oxidized ferredoxin => 1 CO(2) + 2 H(+) + 2 reduced ferredoxin + 1 succinyl-CoA." [] xref: EC:1.2.7.3 xref: GO:0047553 "molecular_function:2-oxoglutarate synthase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00139 ! oxidized ferredoxin relationship: has_input_compound UPa:UPC00139 {cardinality="1", is_alternate="False", is_primary="False"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="True"} ! succinyl-CoA relationship: has_output_compound UPa:UPC00138 ! reduced ferredoxin relationship: has_output_compound UPa:UPC00138 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced ferredoxin relationship: part_of UPa:ULS00491 {cardinality="1", order="1"} ! succinyl-CoA from 2-oxoglutarate (synthase route) relationship: part_of UPa:ULS00491 ! succinyl-CoA from 2-oxoglutarate (synthase route) [Term] id: UPa:UER00999 name: succinate from succinyl-CoA (ligase route): step 1/1 namespace: enzymatic_reaction def: "1 ADP + 1 phosphate + 1 succinyl-CoA => 1 ATP + 1 CoA + 1 succinate." [] xref: EC:6.2.1.5 xref: GO:0004775 "molecular_function:succinate-CoA ligase (ADP-forming) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_input_compound UPa:UPC00008 ! ADP relationship: has_input_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_input_compound UPa:UPC00009 ! phosphate relationship: has_input_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="True"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00002 ! ATP relationship: has_output_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate relationship: part_of UPa:ULS00492 {cardinality="1", order="1"} ! succinate from succinyl-CoA (ligase route) relationship: part_of UPa:ULS00492 ! succinate from succinyl-CoA (ligase route) [Term] id: UPa:UER01000 name: succinate from succinyl-CoA (transferase route): step 1/1 namespace: enzymatic_reaction def: "1 acetoacetate + 1 succinyl-CoA => 1 acetoacetyl-CoA + 1 succinate." [] xref: EC:2.8.3.5 xref: GO:0008260 "molecular_function:3-oxoacid CoA-transferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="True"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00164 ! acetoacetate relationship: has_input_compound UPa:UPC00164 {cardinality="1", is_alternate="False", is_primary="False"} ! acetoacetate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00332 ! acetoacetyl-CoA relationship: has_output_compound UPa:UPC00332 {cardinality="1", is_alternate="False", is_primary="False"} ! acetoacetyl-CoA relationship: part_of UPa:ULS00493 {cardinality="1", order="1"} ! succinate from succinyl-CoA (transferase route) relationship: part_of UPa:ULS00493 ! succinate from succinyl-CoA (transferase route) [Term] id: UPa:UER01001 name: succinate from 2-oxoglutarate (transferase route): step 1/2 namespace: enzymatic_reaction def: "1 2-oxoglutarate => 1 CO(2) + 1 succinate semialdehyde." [] xref: EC:4.1.1.71 xref: GO:0008683 "molecular_function:2-oxoglutarate decarboxylase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00232 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate semialdehyde relationship: has_output_compound UPa:UPC00232 ! succinate semialdehyde relationship: part_of UPa:ULS00494 {cardinality="1", order="1"} ! succinate from 2-oxoglutarate (transferase route) relationship: part_of UPa:ULS00494 ! succinate from 2-oxoglutarate (transferase route) [Term] id: UPa:UER01002 name: succinate from 2-oxoglutarate (transferase route): step 2/2 namespace: enzymatic_reaction def: "H(2)O + succinate semialdehyde + [NAD(+) or NADP(+)] => H(+) + succinate + [NADH or NADPH]." [] xref: EC:1.2.1.16 xref: GO:0009013 "molecular_function:succinate-semialdehyde dehydrogenase [NAD(P)+] activity" is_a: BFO:0000015 ! process relationship: has_alternate_enzymatic_reaction UPa:UER01003 ! None relationship: has_alternate_enzymatic_reaction UPa:UER01004 ! None relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00232 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate semialdehyde relationship: has_input_compound UPa:UPC00232 ! succinate semialdehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:ULS00494 {cardinality="1", order="2"} ! succinate from 2-oxoglutarate (transferase route) relationship: part_of UPa:ULS00494 ! succinate from 2-oxoglutarate (transferase route) [Term] id: UPa:UER01003 name: None namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 succinate semialdehyde => 1 H(+) + 1 NADH + 1 succinate." [] xref: EC:1.2.1.16 xref: GO:0009013 "molecular_function:succinate-semialdehyde dehydrogenase [NAD(P)+] activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00232 ! succinate semialdehyde relationship: has_input_compound UPa:UPC00232 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate semialdehyde relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: part_of UPa:UER01002 ! succinate from 2-oxoglutarate (transferase route): step 2/2 [Term] id: UPa:UER01004 name: None namespace: enzymatic_reaction def: "1 H(2)O + 1 NADP(+) + 1 succinate semialdehyde => 1 H(+) + 1 NADPH + 1 succinate." [] xref: EC:1.2.1.16 xref: GO:0009013 "molecular_function:succinate-semialdehyde dehydrogenase [NAD(P)+] activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00232 ! succinate semialdehyde relationship: has_input_compound UPa:UPC00232 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate semialdehyde relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: part_of UPa:UER01002 ! succinate from 2-oxoglutarate (transferase route): step 2/2 [Term] id: UPa:UER01005 name: fumarate from succinate (bacterial route): step 1/1 namespace: enzymatic_reaction def: "1 acceptor + 1 succinate => 1 fumarate + 1 reduced acceptor." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_input_compound UPa:UPC00028 ! acceptor relationship: has_input_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate relationship: has_input_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_output_compound UPa:UPC00030 ! reduced acceptor relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="True"} ! fumarate relationship: part_of UPa:ULS00495 {cardinality="1", order="1"} ! fumarate from succinate (bacterial route) relationship: part_of UPa:ULS00495 ! fumarate from succinate (bacterial route) [Term] id: UPa:UER01006 name: fumarate from succinate (eukaryal route): step 1/1 namespace: enzymatic_reaction def: "1 Quinone + 1 succinate => 1 Hydroquinone + 1 fumarate." [] xref: EC:1.3.5.1 xref: GO:0008177 "molecular_function:succinate dehydrogenase (ubiquinone) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate relationship: has_input_compound UPa:UPC00042 ! succinate relationship: has_input_compound UPa:UPC15602 {cardinality="1", is_alternate="False", is_primary="False"} ! Quinone relationship: has_input_compound UPa:UPC15602 ! Quinone relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="True"} ! fumarate relationship: has_output_compound UPa:UPC15603 {cardinality="1", is_alternate="False", is_primary="False"} ! Hydroquinone relationship: has_output_compound UPa:UPC15603 ! Hydroquinone relationship: part_of UPa:ULS00496 {cardinality="1", order="1"} ! fumarate from succinate (eukaryal route) relationship: part_of UPa:ULS00496 ! fumarate from succinate (eukaryal route) [Term] id: UPa:UER01007 name: (S)-malate from fumarate: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 fumarate => 1 (S)-malate." [] xref: EC:4.2.1.2 xref: GO:0004333 "molecular_function:fumarate hydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00122 ! fumarate relationship: has_input_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="True"} ! fumarate relationship: has_output_compound UPa:UPC00149 ! (S)-malate relationship: has_output_compound UPa:UPC00149 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-malate relationship: part_of UPa:ULS00497 {cardinality="1", order="1"} ! (S)-malate from fumarate relationship: part_of UPa:ULS00497 ! (S)-malate from fumarate [Term] id: UPa:UER01008 name: oxaloacetate from (S)-malate (quinone route): step 1/1 namespace: enzymatic_reaction def: "1 (S)-malate + 1 Quinone => 1 Hydroquinone + 1 oxaloacetate." [] xref: EC:1.1.5.4 xref: GO:0008924 "molecular_function:malate dehydrogenase (quinone) activity" xref: GO:0052589 "molecular_function:malate dehydrogenase (menaquinone) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00149 ! (S)-malate relationship: has_input_compound UPa:UPC00149 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-malate relationship: has_input_compound UPa:UPC15602 {cardinality="1", is_alternate="False", is_primary="False"} ! Quinone relationship: has_input_compound UPa:UPC15602 ! Quinone relationship: has_output_compound UPa:UPC00036 {cardinality="1", is_alternate="False", is_primary="True"} ! oxaloacetate relationship: has_output_compound UPa:UPC00036 ! oxaloacetate relationship: has_output_compound UPa:UPC15603 {cardinality="1", is_alternate="False", is_primary="False"} ! Hydroquinone relationship: has_output_compound UPa:UPC15603 ! Hydroquinone relationship: part_of UPa:ULS00498 {cardinality="1", order="1"} ! oxaloacetate from (S)-malate (quinone route) relationship: part_of UPa:ULS00498 ! oxaloacetate from (S)-malate (quinone route) [Term] id: UPa:UER01009 name: beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose: step 1/2 namespace: enzymatic_reaction def: "1 D-fructose 6-phosphate + 1 GDP-alpha-D-mannose => 1 GDP + 1 beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate." [] xref: EC:2.4.1.246 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00085 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00096 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00035 ! GDP relationship: has_output_compound UPa:UPC00035 {cardinality="1", is_alternate="False", is_primary="False"} ! GDP relationship: has_output_compound UPa:UPC18050 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate relationship: has_output_compound UPa:UPC18050 ! beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate relationship: part_of UPa:ULS00500 ! beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose relationship: part_of UPa:ULS00500 {cardinality="1", order="1"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose [Term] id: UPa:UER01010 name: beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate => 1 beta-D-fructofuranosyl alpha-D-mannopyranoside + 1 phosphate." [] xref: EC:3.1.3.79 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC18050 ! beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate relationship: has_input_compound UPa:UPC18050 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC18068 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside relationship: has_output_compound UPa:UPC18068 ! beta-D-fructofuranosyl alpha-D-mannopyranoside relationship: part_of UPa:ULS00500 ! beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose relationship: part_of UPa:ULS00500 {cardinality="1", order="2"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose [Term] id: UPa:UER01011 name: 6-hydroxynicotinate from nicotinate: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 NADP(+) + 1 nicotinate => 1 6-hydroxynicotinate + 1 H(+) + 1 NADPH." [] xref: EC:1.17.1.5 xref: GO:0050138 "molecular_function:nicotinate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00253 {cardinality="1", is_alternate="False", is_primary="True"} ! nicotinate relationship: has_input_compound UPa:UPC00253 ! nicotinate relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC01020 ! 6-hydroxynicotinate relationship: has_output_compound UPa:UPC01020 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-hydroxynicotinate relationship: part_of UPa:ULS00501 ! 6-hydroxynicotinate from nicotinate relationship: part_of UPa:ULS00501 {cardinality="1", order="1"} ! 6-hydroxynicotinate from nicotinate [Term] id: UPa:UER01012 name: propanoate and pyruvate from 6-hydroxynicotinate: step 1/8 namespace: enzymatic_reaction def: "1 6-hydroxynicotinate + 1 reduced ferredoxin => 1 6-hydroxynicotinate + 1 oxidized ferredoxin." [] xref: EC:1.3.7.1 xref: GO:0047595 "molecular_function:6-hydroxynicotinate reductase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00138 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced ferredoxin relationship: has_input_compound UPa:UPC00138 ! reduced ferredoxin relationship: has_input_compound UPa:UPC01020 ! 6-hydroxynicotinate relationship: has_input_compound UPa:UPC01020 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-hydroxynicotinate relationship: has_output_compound UPa:UPC00139 {cardinality="1", is_alternate="False", is_primary="False"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00139 ! oxidized ferredoxin relationship: has_output_compound UPa:UPC04226 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-hydroxynicotinate relationship: has_output_compound UPa:UPC04226 ! 6-hydroxynicotinate relationship: part_of UPa:ULS00502 ! propanoate and pyruvate from 6-hydroxynicotinate relationship: part_of UPa:ULS00502 {cardinality="1", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate [Term] id: UPa:UER01013 name: propanoate and pyruvate from 6-hydroxynicotinate: step 2/8 namespace: enzymatic_reaction def: "1 6-hydroxynicotinate + 2 H(2)O => 1 2-formylglutarate + 1 NH(3)." [] xref: EC:3.5.2.18 xref: GO:0043792 "molecular_function:enamidase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC04226 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-hydroxynicotinate relationship: has_input_compound UPa:UPC04226 ! 6-hydroxynicotinate relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC16159 ! 2-formylglutarate relationship: has_output_compound UPa:UPC16159 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-formylglutarate relationship: part_of UPa:ULS00502 ! propanoate and pyruvate from 6-hydroxynicotinate relationship: part_of UPa:ULS00502 {cardinality="1", order="2"} ! propanoate and pyruvate from 6-hydroxynicotinate [Term] id: UPa:UER01014 name: propanoate and pyruvate from 6-hydroxynicotinate: step 3/8 namespace: enzymatic_reaction def: "1 2-formylglutarate + 1 H(+) + 1 NADH => 1 2-hydroxymethylglutarate + 1 NAD(+)." [] xref: EC:1.1.1.291 xref: GO:0043718 "molecular_function:2-hydroxymethylglutarate dehydrogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC16159 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-formylglutarate relationship: has_input_compound UPa:UPC16159 ! 2-formylglutarate relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC16390 ! 2-hydroxymethylglutarate relationship: has_output_compound UPa:UPC16390 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxymethylglutarate relationship: part_of UPa:ULS00502 ! propanoate and pyruvate from 6-hydroxynicotinate relationship: part_of UPa:ULS00502 {cardinality="1", order="3"} ! propanoate and pyruvate from 6-hydroxynicotinate [Term] id: UPa:UER01015 name: propanoate and pyruvate from 6-hydroxynicotinate: step 4/8 namespace: enzymatic_reaction def: "1 2-hydroxymethylglutarate => 1 2-methyleneglutarate + 1 H(2)O." [] is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC16390 ! 2-hydroxymethylglutarate relationship: has_input_compound UPa:UPC16390 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxymethylglutarate relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC02930 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-methyleneglutarate relationship: has_output_compound UPa:UPC02930 ! 2-methyleneglutarate relationship: part_of UPa:ULS00502 ! propanoate and pyruvate from 6-hydroxynicotinate relationship: part_of UPa:ULS00502 {cardinality="1", order="4"} ! propanoate and pyruvate from 6-hydroxynicotinate [Term] id: UPa:UER01016 name: propanoate and pyruvate from 6-hydroxynicotinate: step 5/8 namespace: enzymatic_reaction def: "1 2-methyleneglutarate => 1 2-methylene-3-methylsuccinate." [] xref: EC:5.4.99.4 xref: GO:0047548 "molecular_function:2-methyleneglutarate mutase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC02930 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-methyleneglutarate relationship: has_input_compound UPa:UPC02930 ! 2-methyleneglutarate relationship: has_output_compound UPa:UPC02295 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-methylene-3-methylsuccinate relationship: has_output_compound UPa:UPC02295 ! 2-methylene-3-methylsuccinate relationship: part_of UPa:ULS00502 ! propanoate and pyruvate from 6-hydroxynicotinate relationship: part_of UPa:ULS00502 {cardinality="1", order="5"} ! propanoate and pyruvate from 6-hydroxynicotinate [Term] id: UPa:UER01017 name: propanoate and pyruvate from 6-hydroxynicotinate: step 6/8 namespace: enzymatic_reaction def: "1 2-methylene-3-methylsuccinate => 1 dimethylmaleate." [] xref: EC:5.3.3.6 xref: GO:0050100 "molecular_function:methylitaconate delta-isomerase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC02295 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-methylene-3-methylsuccinate relationship: has_input_compound UPa:UPC02295 ! 2-methylene-3-methylsuccinate relationship: has_output_compound UPa:UPC00922 {cardinality="1", is_alternate="False", is_primary="True"} ! dimethylmaleate relationship: has_output_compound UPa:UPC00922 ! dimethylmaleate relationship: part_of UPa:ULS00502 {cardinality="1", order="6"} ! propanoate and pyruvate from 6-hydroxynicotinate relationship: part_of UPa:ULS00502 ! propanoate and pyruvate from 6-hydroxynicotinate [Term] id: UPa:UER01018 name: propanoate and pyruvate from 6-hydroxynicotinate: step 7/8 namespace: enzymatic_reaction def: "1 H(2)O + 1 dimethylmaleate => 1 (2R,3S)-2,3-dimethylmalate." [] xref: EC:4.2.1.85 xref: GO:0047868 "molecular_function:dimethylmaleate hydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00922 ! dimethylmaleate relationship: has_input_compound UPa:UPC00922 {cardinality="1", is_alternate="False", is_primary="True"} ! dimethylmaleate relationship: has_output_compound UPa:UPC03652 ! (2R,3S)-2,3-dimethylmalate relationship: has_output_compound UPa:UPC03652 {cardinality="1", is_alternate="False", is_primary="True"} ! (2R,3S)-2,3-dimethylmalate relationship: part_of UPa:ULS00502 {cardinality="1", order="7"} ! propanoate and pyruvate from 6-hydroxynicotinate relationship: part_of UPa:ULS00502 ! propanoate and pyruvate from 6-hydroxynicotinate [Term] id: UPa:UER01019 name: propanoate and pyruvate from 6-hydroxynicotinate: step 8/8 namespace: enzymatic_reaction def: "1 (2R,3S)-2,3-dimethylmalate => 1 propanoate + 1 pyruvate." [] xref: EC:4.1.3.32 xref: GO:0047529 "molecular_function:2,3-dimethylmalate lyase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC03652 ! (2R,3S)-2,3-dimethylmalate relationship: has_input_compound UPa:UPC03652 {cardinality="1", is_alternate="False", is_primary="True"} ! (2R,3S)-2,3-dimethylmalate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00163 {cardinality="1", is_alternate="False", is_primary="True"} ! propanoate relationship: has_output_compound UPa:UPC00163 ! propanoate relationship: part_of UPa:ULS00502 {cardinality="1", order="8"} ! propanoate and pyruvate from 6-hydroxynicotinate relationship: part_of UPa:ULS00502 ! propanoate and pyruvate from 6-hydroxynicotinate [Term] id: UPa:UER01020 name: 4-hydroxybenzoate from 4-chlorobenzoate: step 1/3 namespace: enzymatic_reaction def: "1 4-chlorobenzoate + 1 ATP + 1 CoA => 1 4-chlorobenzoyl-CoA + 1 AMP + 1 diphosphate." [] xref: EC:6.2.1.33 xref: GO:0018861 "molecular_function:4-chlorobenzoate-CoA ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00010 ! CoA relationship: has_input_compound UPa:UPC02370 ! 4-chlorobenzoate relationship: has_input_compound UPa:UPC02370 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-chlorobenzoate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC06387 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-chlorobenzoyl-CoA relationship: has_output_compound UPa:UPC06387 ! 4-chlorobenzoyl-CoA relationship: part_of UPa:ULS00503 {cardinality="1", order="1"} ! 4-hydroxybenzoate from 4-chlorobenzoate relationship: part_of UPa:ULS00503 ! 4-hydroxybenzoate from 4-chlorobenzoate [Term] id: UPa:UER01021 name: 4-hydroxybenzoate from 4-chlorobenzoate: step 2/3 namespace: enzymatic_reaction def: "1 4-chlorobenzoyl-CoA + 1 H(2)O => 1 4-hydroxybenzoyl-CoA + 1 H(+) + 1 chloride." [] xref: EC:3.8.1.7 xref: GO:0018787 "molecular_function:4-chlorobenzoyl-CoA dehalogenase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC06387 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-chlorobenzoyl-CoA relationship: has_input_compound UPa:UPC06387 ! 4-chlorobenzoyl-CoA relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00698 {cardinality="1", is_alternate="False", is_primary="False"} ! chloride relationship: has_output_compound UPa:UPC00698 ! chloride relationship: has_output_compound UPa:UPC02949 ! 4-hydroxybenzoyl-CoA relationship: has_output_compound UPa:UPC02949 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-hydroxybenzoyl-CoA relationship: part_of UPa:ULS00503 {cardinality="1", order="2"} ! 4-hydroxybenzoate from 4-chlorobenzoate relationship: part_of UPa:ULS00503 ! 4-hydroxybenzoate from 4-chlorobenzoate [Term] id: UPa:UER01022 name: 4-hydroxybenzoate from 4-chlorobenzoate: step 3/3 namespace: enzymatic_reaction def: "1 4-hydroxybenzoyl-CoA + 1 H(2)O => 1 4-hydroxybenzoate + 1 CoA." [] xref: EC:3.1.2.23 xref: GO:0018739 "molecular_function:4-hydroxybenzoyl-CoA thioesterase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC02949 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-hydroxybenzoyl-CoA relationship: has_input_compound UPa:UPC02949 ! 4-hydroxybenzoyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00156 ! 4-hydroxybenzoate relationship: has_output_compound UPa:UPC00156 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-hydroxybenzoate relationship: part_of UPa:ULS00503 {cardinality="1", order="3"} ! 4-hydroxybenzoate from 4-chlorobenzoate relationship: part_of UPa:ULS00503 ! 4-hydroxybenzoate from 4-chlorobenzoate [Term] id: UPa:UER01023 name: glycine from L-serine: step 1/1 namespace: enzymatic_reaction def: "1 5,6,7,8-tetrahydrofolate + 1 L-serine => 1 5,10-methylene-THF + 1 H(2)O + 1 glycine." [] xref: EC:2.1.2.1 xref: GO:0004372 "molecular_function:glycine hydroxymethyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="True"} ! L-serine relationship: has_input_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="True"} ! glycine relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00143 ! 5,10-methylene-THF relationship: has_output_compound UPa:UPC00143 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,10-methylene-THF relationship: part_of UPa:ULS00504 {cardinality="1", order="1"} ! glycine from L-serine relationship: part_of UPa:ULS00504 ! glycine from L-serine [Term] id: UPa:UER01024 name: L-aspartate from oxaloacetate: step 1/1 namespace: enzymatic_reaction def: "1 L-glutamate + 1 oxaloacetate => 1 2-oxoglutarate + 1 L-aspartate." [] xref: EC:2.6.1.1 xref: GO:0004069 "molecular_function:L-aspartate:2-oxoglutarate aminotransferase activity" xref: GO:0080130 "molecular_function:L-phenylalanine:2-oxoglutarate aminotransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00036 ! oxaloacetate relationship: has_input_compound UPa:UPC00036 {cardinality="1", is_alternate="False", is_primary="True"} ! oxaloacetate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_output_compound UPa:UPC00049 ! L-aspartate relationship: part_of UPa:ULS00505 {cardinality="1", order="1"} ! L-aspartate from oxaloacetate relationship: part_of UPa:ULS00505 ! L-aspartate from oxaloacetate [Term] id: UPa:UER01025 name: L-glutamine from L-glutamate: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 L-glutamate + 1 NH(3) => 1 ADP + 1 L-glutamine + 1 phosphate." [] xref: EC:6.3.1.2 xref: GO:0004356 "molecular_function:glutamate-ammonia ligase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00002 ! ATP relationship: has_input_compound UPa:UPC00014 ! NH(3) relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00009 ! phosphate relationship: has_output_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamine relationship: has_output_compound UPa:UPC00064 ! L-glutamine relationship: part_of UPa:ULS00506 {cardinality="1", order="1"} ! L-glutamine from L-glutamate relationship: part_of UPa:ULS00506 ! L-glutamine from L-glutamate [Term] id: UPa:UER01026 name: catechol from anthranilate: step 1/1 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 anthranilate => 1 CO(2) + 1 NAD(+) + 1 NH(3) + 1 catechol." [] xref: EC:1.14.12.1 xref: GO:0018618 "molecular_function:anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00007 ! O(2) relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC00108 {cardinality="1", is_alternate="False", is_primary="True"} ! anthranilate relationship: has_input_compound UPa:UPC00108 ! anthranilate relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00090 {cardinality="1", is_alternate="False", is_primary="True"} ! catechol relationship: has_output_compound UPa:UPC00090 ! catechol relationship: part_of UPa:ULS00507 {cardinality="1", order="1"} ! catechol from anthranilate relationship: part_of UPa:ULS00507 ! catechol from anthranilate [Term] id: UPa:UER01027 name: L-alpha-aminoadipate from 2-oxoglutarate: step 3/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 homo-cis-aconitate => 1 homoisocitrate." [] xref: EC:4.2.1.36 xref: GO:0004409 "molecular_function:homoaconitate hydratase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC04002 ! homo-cis-aconitate relationship: has_input_compound UPa:UPC04002 {cardinality="1", is_alternate="False", is_primary="True"} ! homo-cis-aconitate relationship: has_output_compound UPa:UPC05662 ! homoisocitrate relationship: has_output_compound UPa:UPC05662 {cardinality="1", is_alternate="False", is_primary="True"} ! homoisocitrate relationship: part_of UPa:ULS00012 {cardinality="1", order="3"} ! L-alpha-aminoadipate from 2-oxoglutarate relationship: part_of UPa:ULS00012 ! L-alpha-aminoadipate from 2-oxoglutarate [Term] id: UPa:UER01028 name: None namespace: enzymatic_reaction def: "1 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + 1 H(+) + 1 NADH => 1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 NAD(+)." [] xref: EC:1.17.1.8 xref: GO:0008839 "molecular_function:4-hydroxy-tetrahydrodipicolinate reductase" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00004 ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC20258 ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC20258 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC03972 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-tetrahydrodipicolinate relationship: part_of UPa:UER00018 ! (S)-tetrahydrodipicolinate from L-aspartate: step 4/4 [Term] id: UPa:UER01029 name: None namespace: enzymatic_reaction def: "1 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + 1 H(+) + 1 NADPH => 1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.17.1.8 xref: GO:0008839 "molecular_function:4-hydroxy-tetrahydrodipicolinate reductase" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00005 ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00080 ! H(+) relationship: has_input_compound UPa:UPC20258 ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC20258 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00001 ! H(2)O relationship: has_output_compound UPa:UPC00006 ! NADP(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC03972 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-tetrahydrodipicolinate relationship: part_of UPa:UER00018 ! (S)-tetrahydrodipicolinate from L-aspartate: step 4/4 [Term] id: UPa:UER01030 name: 15-cis-phytoene from geranylgeranyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "2 geranylgeranyl diphosphate => 1 15-cis-phytoene + 1 diphosphate." [] xref: EC:2.5.1.32 xref: GO:0016767 "molecular_function:geranylgeranyl-diphosphate geranylgeranyltransferase activity" is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00353 {cardinality="1", is_alternate="False", is_primary="True"} ! geranylgeranyl diphosphate relationship: has_input_compound UPa:UPC00353 ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC00013 ! diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC05421 ! 15-cis-phytoene relationship: has_output_compound UPa:UPC05421 {cardinality="1", is_alternate="False", is_primary="True"} ! 15-cis-phytoene relationship: part_of UPa:ULS00508 ! 15-cis-phytoene from geranylgeranyl diphosphate relationship: part_of UPa:ULS00508 {cardinality="1", order="1"} ! 15-cis-phytoene from geranylgeranyl diphosphate [Term] id: UPa:UER01031 name: None namespace: enzymatic_reaction def: "1 2-deoxy-scyllo-inosamine + 1 NAD(+) => 1 3-amino-2,3-dideoxy-scyllo-inosose + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.329 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00003 ! NAD(+) relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC17580 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxy-scyllo-inosamine relationship: has_input_compound UPa:UPC17580 ! 2-deoxy-scyllo-inosamine relationship: has_output_compound UPa:UPC00004 ! NADH relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC17581 ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: has_output_compound UPa:UPC17581 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: part_of UPa:UER00923 ! 2-deoxystreptamine from D-glucose 6-phosphate: step 3/4 [Term] id: UPa:UER01032 name: None namespace: enzymatic_reaction def: "1 2-deoxy-scyllo-inosamine + 1 NADP(+) => 1 3-amino-2,3-dideoxy-scyllo-inosose + 1 H(+) + 1 NADPH." [] xref: EC:1.1.1.329 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00006 ! NADP(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC17580 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxy-scyllo-inosamine relationship: has_input_compound UPa:UPC17580 ! 2-deoxy-scyllo-inosamine relationship: has_output_compound UPa:UPC00005 ! NADPH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00080 ! H(+) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC17581 ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: has_output_compound UPa:UPC17581 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: part_of UPa:UER00923 ! 2-deoxystreptamine from D-glucose 6-phosphate: step 3/4 [Term] id: UPa:UER01033 name: 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7 namespace: enzymatic_reaction def: "1 1,4-dihydroxy-2-naphthoyl-CoA + 1 H(2)O => 1 1,4-dihydroxy-2-naphthoate + 1 CoA." [] xref: EC:3.1.2.28 is_a: BFO:0000015 ! process relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00001 ! H(2)O relationship: has_input_compound UPa:UPC15547 ! 1,4-dihydroxy-2-naphthoyl-CoA relationship: has_input_compound UPa:UPC15547 {cardinality="1", is_alternate="False", is_primary="True"} ! 1,4-dihydroxy-2-naphthoyl-CoA relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC03657 ! 1,4-dihydroxy-2-naphthoate relationship: has_output_compound UPa:UPC03657 {cardinality="1", is_alternate="False", is_primary="True"} ! 1,4-dihydroxy-2-naphthoate relationship: part_of UPa:ULS00509 ! 1,4-dihydroxy-2-naphthoate from chorismate relationship: part_of UPa:ULS00509 {cardinality="1", order="7"} ! 1,4-dihydroxy-2-naphthoate from chorismate [Term] id: UPa:ULS00000 name: linear sub-pathway namespace: linear_sub_pathway def: "A linear sub-pathway involved in a UniPathway pathway. A linear sub-pathway is a path of enzymatic reactions." [] [Term] id: UPa:ULS00002 name: beta-alanine from L-aspartate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00099 {cardinality="1"} ! beta-alanine relationship: has_output_compound UPa:UPC00099 ! beta-alanine relationship: part_of UPa:UPA00028 {cardinality="1"} ! (R)-pantothenate biosynthesis relationship: part_of UPa:UPA00028 ! (R)-pantothenate biosynthesis [Term] id: UPa:ULS00003 name: (R)-pantoate from 3-methyl-2-oxobutanoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate relationship: has_input_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate relationship: has_output_compound UPa:UPC00522 {cardinality="1"} ! (R)-pantoate relationship: has_output_compound UPa:UPC00522 ! (R)-pantoate relationship: part_of UPa:UPA00028 {cardinality="1"} ! (R)-pantothenate biosynthesis relationship: part_of UPa:UPA00028 ! (R)-pantothenate biosynthesis [Term] id: UPa:ULS00004 name: (R)-pantothenate from (R)-pantoate and beta-alanine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00099 {cardinality="1"} ! beta-alanine relationship: has_input_compound UPa:UPC00099 ! beta-alanine relationship: has_input_compound UPa:UPC00522 {cardinality="1"} ! (R)-pantoate relationship: has_input_compound UPa:UPC00522 ! (R)-pantoate relationship: has_output_compound UPa:UPC00864 ! (R)-pantothenate relationship: has_output_compound UPa:UPC00864 {cardinality="1"} ! (R)-pantothenate relationship: part_of UPa:UPA00028 {cardinality="1"} ! (R)-pantothenate biosynthesis relationship: part_of UPa:UPA00028 ! (R)-pantothenate biosynthesis [Term] id: UPa:ULS00005 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00135 ! L-histidine relationship: has_output_compound UPa:UPC00135 {cardinality="1"} ! L-histidine relationship: part_of UPa:UPA00031 {cardinality="1"} ! L-histidine biosynthesis relationship: part_of UPa:UPA00031 ! L-histidine biosynthesis [Term] id: UPa:ULS00006 name: (S)-tetrahydrodipicolinate from L-aspartate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: part_of UPa:UPA00034 {cardinality="1"} ! L-lysine biosynthesis via DAP pathway relationship: part_of UPa:UPA00034 ! L-lysine biosynthesis via DAP pathway [Term] id: UPa:ULS00007 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00666 ! LL-2,6-diaminopimelate relationship: part_of UPa:UPA00034 {cardinality="1"} ! L-lysine biosynthesis via DAP pathway relationship: part_of UPa:UPA00034 ! L-lysine biosynthesis via DAP pathway [Term] id: UPa:ULS00008 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00666 ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate relationship: part_of UPa:UPA00034 {cardinality="1"} ! L-lysine biosynthesis via DAP pathway relationship: part_of UPa:UPA00034 ! L-lysine biosynthesis via DAP pathway [Term] id: UPa:ULS00009 name: DL-2,6-diaminopimelate from LL-2,6-diaminopimelate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC00666 ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00680 ! DL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00680 {cardinality="1"} ! DL-2,6-diaminopimelate relationship: part_of UPa:UPA00034 {cardinality="1"} ! L-lysine biosynthesis via DAP pathway relationship: part_of UPa:UPA00034 ! L-lysine biosynthesis via DAP pathway [Term] id: UPa:ULS00010 name: DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00680 {cardinality="1"} ! DL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00680 ! DL-2,6-diaminopimelate relationship: part_of UPa:UPA00034 ! L-lysine biosynthesis via DAP pathway relationship: part_of UPa:UPA00034 {cardinality="1"} ! L-lysine biosynthesis via DAP pathway [Term] id: UPa:ULS00011 name: L-lysine from DL-2,6-diaminopimelate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00680 {cardinality="1"} ! DL-2,6-diaminopimelate relationship: has_input_compound UPa:UPC00680 ! DL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: part_of UPa:UPA00034 ! L-lysine biosynthesis via DAP pathway relationship: part_of UPa:UPA00034 {cardinality="1"} ! L-lysine biosynthesis via DAP pathway [Term] id: UPa:ULS00012 name: L-alpha-aminoadipate from 2-oxoglutarate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: part_of UPa:UPA00033 ! L-lysine biosynthesis via AAA pathway relationship: part_of UPa:UPA00033 {cardinality="1"} ! L-lysine biosynthesis via AAA pathway [Term] id: UPa:ULS00013 name: L-lysine from L-alpha-aminoadipate (fungal route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: part_of UPa:UPA00033 ! L-lysine biosynthesis via AAA pathway relationship: part_of UPa:UPA00033 {cardinality="1"} ! L-lysine biosynthesis via AAA pathway [Term] id: UPa:ULS00014 name: L-lysine from L-alpha-aminoadipate (Thermus route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: part_of UPa:UPA00033 ! L-lysine biosynthesis via AAA pathway relationship: part_of UPa:UPA00033 {cardinality="1"} ! L-lysine biosynthesis via AAA pathway [Term] id: UPa:ULS00015 name: sulfoacetaldehyde from phosphoenolpyruvate and sulfite namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00094 ! sulfite relationship: has_input_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_output_compound UPa:UPC00593 ! sulfoacetaldehyde relationship: has_output_compound UPa:UPC00593 {cardinality="1"} ! sulfoacetaldehyde relationship: part_of UPa:UPA00355 {cardinality="1"} ! coenzyme M biosynthesis relationship: part_of UPa:UPA00355 ! coenzyme M biosynthesis [Term] id: UPa:ULS00016 name: L-tryptophan from chorismate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00251 ! chorismate relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: has_output_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan relationship: has_output_compound UPa:UPC00078 ! L-tryptophan relationship: part_of UPa:UPA00035 ! L-tryptophan biosynthesis relationship: part_of UPa:UPA00035 {cardinality="1"} ! L-tryptophan biosynthesis [Term] id: UPa:ULS00017 name: 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC01187 ! 3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC01187 {cardinality="1"} ! 3-deoxy-D-manno-octulosonate relationship: part_of UPa:UPA00357 {cardinality="1"} ! 3-deoxy-D-manno-octulosonate biosynthesis relationship: part_of UPa:UPA00357 ! 3-deoxy-D-manno-octulosonate biosynthesis [Term] id: UPa:ULS00018 name: 2-oxobutanoate from L-threonine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: has_input_compound UPa:UPC00188 ! L-threonine relationship: has_output_compound UPa:UPC00109 ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: part_of UPa:UPA00047 ! L-isoleucine biosynthesis relationship: part_of UPa:UPA00047 {cardinality="1"} ! L-isoleucine biosynthesis [Term] id: UPa:ULS00019 name: 2-oxobutanoate from pyruvate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00109 ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: part_of UPa:UPA00047 ! L-isoleucine biosynthesis relationship: part_of UPa:UPA00047 {cardinality="1"} ! L-isoleucine biosynthesis [Term] id: UPa:ULS00020 name: L-isoleucine from 2-oxobutanoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: has_input_compound UPa:UPC00109 ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00407 ! L-isoleucine relationship: has_output_compound UPa:UPC00407 {cardinality="1"} ! L-isoleucine relationship: part_of UPa:UPA00047 {cardinality="1"} ! L-isoleucine biosynthesis relationship: part_of UPa:UPA00047 ! L-isoleucine biosynthesis [Term] id: UPa:ULS00021 name: L-valine from pyruvate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00183 ! L-valine relationship: has_output_compound UPa:UPC00183 {cardinality="1"} ! L-valine relationship: part_of UPa:UPA00049 {cardinality="1"} ! L-valine biosynthesis relationship: part_of UPa:UPA00049 ! L-valine biosynthesis [Term] id: UPa:ULS00022 name: L-threonine from L-aspartate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00188 ! L-threonine relationship: has_output_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: part_of UPa:UPA00050 {cardinality="1"} ! L-threonine biosynthesis relationship: part_of UPa:UPA00050 ! L-threonine biosynthesis [Term] id: UPa:ULS00023 name: L-leucine from 3-methyl-2-oxobutanoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate relationship: has_input_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate relationship: has_output_compound UPa:UPC00123 ! L-leucine relationship: has_output_compound UPa:UPC00123 {cardinality="1"} ! L-leucine relationship: part_of UPa:UPA00048 {cardinality="1"} ! L-leucine biosynthesis relationship: part_of UPa:UPA00048 ! L-leucine biosynthesis [Term] id: UPa:ULS00025 name: L-homoserine from L-aspartate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00263 ! L-homoserine relationship: has_output_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: part_of UPa:UPA00051 {cardinality="1"} ! L-methionine biosynthesis via de novo pathway relationship: part_of UPa:UPA00051 ! L-methionine biosynthesis via de novo pathway [Term] id: UPa:ULS00026 name: O-acetyl-L-homoserine from L-homoserine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: has_input_compound UPa:UPC00263 ! L-homoserine relationship: has_output_compound UPa:UPC01077 ! O-acetyl-L-homoserine relationship: has_output_compound UPa:UPC01077 {cardinality="1"} ! O-acetyl-L-homoserine relationship: part_of UPa:UPA00051 {cardinality="1"} ! L-methionine biosynthesis via de novo pathway relationship: part_of UPa:UPA00051 ! L-methionine biosynthesis via de novo pathway [Term] id: UPa:ULS00027 name: O-succinyl-L-homoserine from L-homoserine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: has_input_compound UPa:UPC00263 ! L-homoserine relationship: has_output_compound UPa:UPC01118 ! O-succinyl-L-homoserine relationship: has_output_compound UPa:UPC01118 {cardinality="1"} ! O-succinyl-L-homoserine relationship: part_of UPa:UPA00051 {cardinality="1"} ! L-methionine biosynthesis via de novo pathway relationship: part_of UPa:UPA00051 ! L-methionine biosynthesis via de novo pathway [Term] id: UPa:ULS00028 name: L-homocysteine from S-adenosyl-L-homocysteine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_input_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00155 ! L-homocysteine relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: part_of UPa:UPA00314 ! L-homocysteine biosynthesis relationship: part_of UPa:UPA00314 {cardinality="1"} ! L-homocysteine biosynthesis [Term] id: UPa:ULS00029 name: L-cystathionine from O-succinyl-L-homoserine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01118 ! O-succinyl-L-homoserine relationship: has_input_compound UPa:UPC01118 {cardinality="1"} ! O-succinyl-L-homoserine relationship: has_output_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: has_output_compound UPa:UPC02291 ! L-cystathionine relationship: part_of UPa:UPA00051 {cardinality="1"} ! L-methionine biosynthesis via de novo pathway relationship: part_of UPa:UPA00051 ! L-methionine biosynthesis via de novo pathway [Term] id: UPa:ULS00030 name: L-homocysteine from L-cystathionine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC02291 ! L-cystathionine relationship: has_input_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_output_compound UPa:UPC00155 ! L-homocysteine relationship: part_of UPa:UPA00051 ! L-methionine biosynthesis via de novo pathway relationship: part_of UPa:UPA00051 {cardinality="1"} ! L-methionine biosynthesis via de novo pathway [Term] id: UPa:ULS00031 name: L-homocysteine from O-acetyl-L-homoserine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01077 ! O-acetyl-L-homoserine relationship: has_input_compound UPa:UPC01077 {cardinality="1"} ! O-acetyl-L-homoserine relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_output_compound UPa:UPC00155 ! L-homocysteine relationship: part_of UPa:UPA00051 ! L-methionine biosynthesis via de novo pathway relationship: part_of UPa:UPA00051 {cardinality="1"} ! L-methionine biosynthesis via de novo pathway [Term] id: UPa:ULS00032 name: S-adenosyl-L-methionine from L-methionine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00073 ! L-methionine relationship: has_input_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_output_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: part_of UPa:UPA00315 ! S-adenosyl-L-methionine biosynthesis relationship: part_of UPa:UPA00315 {cardinality="1"} ! S-adenosyl-L-methionine biosynthesis [Term] id: UPa:ULS00033 name: L-methionine from L-homocysteine (MetH route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: part_of UPa:UPA00051 ! L-methionine biosynthesis via de novo pathway relationship: part_of UPa:UPA00051 {cardinality="1"} ! L-methionine biosynthesis via de novo pathway [Term] id: UPa:ULS00034 name: L-methionine from L-homocysteine (MetE route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: part_of UPa:UPA00051 ! L-methionine biosynthesis via de novo pathway relationship: part_of UPa:UPA00051 {cardinality="1"} ! L-methionine biosynthesis via de novo pathway [Term] id: UPa:ULS00035 name: L-methionine from L-homocysteine (BhmT route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: part_of UPa:UPA00051 ! L-methionine biosynthesis via de novo pathway relationship: part_of UPa:UPA00051 {cardinality="1"} ! L-methionine biosynthesis via de novo pathway [Term] id: UPa:ULS00036 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00074 ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00074 {cardinality="2"} ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00279 ! D-erythrose 4-phosphate relationship: has_input_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00251 ! chorismate relationship: has_output_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: part_of UPa:UPA00053 ! chorismate biosynthesis relationship: part_of UPa:UPA00053 {cardinality="1"} ! chorismate biosynthesis [Term] id: UPa:ULS00037 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_output_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: part_of UPa:UPA00056 ! isopentenyl diphosphate biosynthesis via DXP pathway relationship: part_of UPa:UPA00056 {cardinality="1"} ! isopentenyl diphosphate biosynthesis via DXP pathway [Term] id: UPa:ULS00038 name: isopentenyl diphosphate from (R)-mevalonate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00418 {cardinality="1"} ! (R)-mevalonate relationship: has_input_compound UPa:UPC00418 ! (R)-mevalonate relationship: has_output_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_output_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: part_of UPa:UPA00057 ! isopentenyl diphosphate biosynthesis via mevalonate pathway relationship: part_of UPa:UPA00057 {cardinality="1"} ! isopentenyl diphosphate biosynthesis via mevalonate pathway [Term] id: UPa:ULS00039 name: (R)-mevalonate from acetyl-CoA namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 {cardinality="3"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00418 {cardinality="1"} ! (R)-mevalonate relationship: has_output_compound UPa:UPC00418 ! (R)-mevalonate relationship: part_of UPa:UPA00058 ! (R)-mevalonate biosynthesis relationship: part_of UPa:UPA00058 {cardinality="1"} ! (R)-mevalonate biosynthesis [Term] id: UPa:ULS00040 name: 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:UPA00064 ! 1-deoxy-D-xylulose 5-phosphate biosynthesis relationship: part_of UPa:UPA00064 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate biosynthesis [Term] id: UPa:ULS00041 name: dimethylallyl diphosphate from isopentenyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_output_compound UPa:UPC00235 ! dimethylallyl diphosphate relationship: has_output_compound UPa:UPC00235 {cardinality="1"} ! dimethylallyl diphosphate relationship: part_of UPa:UPA00059 ! dimethylallyl diphosphate biosynthesis relationship: part_of UPa:UPA00059 {cardinality="1"} ! dimethylallyl diphosphate biosynthesis [Term] id: UPa:ULS00042 name: dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC11811 ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_input_compound UPa:UPC11811 {cardinality="1"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_output_compound UPa:UPC00235 ! dimethylallyl diphosphate relationship: has_output_compound UPa:UPC00235 {cardinality="1"} ! dimethylallyl diphosphate relationship: part_of UPa:UPA00059 {cardinality="1"} ! dimethylallyl diphosphate biosynthesis relationship: part_of UPa:UPA00059 ! dimethylallyl diphosphate biosynthesis [Term] id: UPa:ULS00043 name: N(2)-acetyl-L-ornithine from L-glutamate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00025 {cardinality="2"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00437 ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00437 {cardinality="1"} ! N(2)-acetyl-L-ornithine relationship: part_of UPa:UPA00068 {cardinality="1"} ! L-arginine biosynthesis relationship: part_of UPa:UPA00068 ! L-arginine biosynthesis [Term] id: UPa:ULS00044 name: L-ornithine from N(2)-acetyl-L-ornithine (linear) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00437 {cardinality="1"} ! N(2)-acetyl-L-ornithine relationship: has_input_compound UPa:UPC00437 ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: part_of UPa:UPA00068 {cardinality="1"} ! L-arginine biosynthesis relationship: part_of UPa:UPA00068 ! L-arginine biosynthesis [Term] id: UPa:ULS00045 name: L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00437 {cardinality="1"} ! N(2)-acetyl-L-ornithine relationship: has_input_compound UPa:UPC00437 ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00624 {cardinality="1"} ! N-acetyl-L-glutamate relationship: has_output_compound UPa:UPC00624 ! N-acetyl-L-glutamate relationship: part_of UPa:UPA00068 {cardinality="1"} ! L-arginine biosynthesis relationship: part_of UPa:UPA00068 ! L-arginine biosynthesis [Term] id: UPa:ULS00046 name: L-arginine from L-ornithine and carbamoyl phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_input_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00062 ! L-arginine relationship: has_output_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: part_of UPa:UPA00068 {cardinality="1"} ! L-arginine biosynthesis relationship: part_of UPa:UPA00068 ! L-arginine biosynthesis [Term] id: UPa:ULS00048 name: L-ectoine from L-aspartate 4-semialdehyde namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC06231 ! L-ectoine relationship: has_output_compound UPa:UPC06231 {cardinality="1"} ! L-ectoine relationship: part_of UPa:UPA00067 {cardinality="1"} ! ectoine biosynthesis relationship: part_of UPa:UPA00067 ! ectoine biosynthesis [Term] id: UPa:ULS00049 name: D-xylulose 5-phosphate from L-arabinose (bacterial route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose relationship: has_input_compound UPa:UPC00259 ! L-arabinose relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: part_of UPa:UPA00145 ! L-arabinose degradation via L-ribulose relationship: part_of UPa:UPA00145 {cardinality="1"} ! L-arabinose degradation via L-ribulose [Term] id: UPa:ULS00050 name: N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC03838 ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC03838 {cardinality="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:UPA00074 ! IMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00074 {cardinality="1"} ! IMP biosynthesis via de novo pathway [Term] id: UPa:ULS00051 name: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03838 {cardinality="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_input_compound UPa:UPC03838 ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC04376 {cardinality="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC04376 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:UPA00074 ! IMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00074 {cardinality="1"} ! IMP biosynthesis via de novo pathway [Term] id: UPa:ULS00052 name: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03838 {cardinality="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_input_compound UPa:UPC03838 ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC04376 {cardinality="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC04376 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:UPA00074 ! IMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00074 {cardinality="1"} ! IMP biosynthesis via de novo pathway [Term] id: UPa:ULS00054 name: 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04734 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04734 {cardinality="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UPA00074 ! IMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00074 {cardinality="1"} ! IMP biosynthesis via de novo pathway [Term] id: UPa:ULS00055 name: 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04734 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04734 {cardinality="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UPA00074 ! IMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00074 {cardinality="1"} ! IMP biosynthesis via de novo pathway [Term] id: UPa:ULS00056 name: IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04734 {cardinality="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04734 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00130 ! IMP relationship: has_output_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: part_of UPa:UPA00074 ! IMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00074 {cardinality="1"} ! IMP biosynthesis via de novo pathway [Term] id: UPa:ULS00057 name: 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_input_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC04752 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: has_output_compound UPa:UPC04752 {cardinality="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: part_of UPa:UPA00060 ! thiamine diphosphate biosynthesis relationship: part_of UPa:UPA00060 {cardinality="1"} ! thiamine diphosphate biosynthesis [Term] id: UPa:ULS00058 name: 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04294 {cardinality="1"} ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: has_input_compound UPa:UPC04294 ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: has_output_compound UPa:UPC04327 {cardinality="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_output_compound UPa:UPC04327 ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: part_of UPa:UPA00060 ! thiamine diphosphate biosynthesis relationship: part_of UPa:UPA00060 {cardinality="1"} ! thiamine diphosphate biosynthesis [Term] id: UPa:ULS00059 name: 4-methyl-5-(2-phosphoethyl)-thiazole from 1-deoxy-D-xylulose 5-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC04327 {cardinality="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_output_compound UPa:UPC04327 ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: part_of UPa:UPA00060 ! thiamine diphosphate biosynthesis relationship: part_of UPa:UPA00060 {cardinality="1"} ! thiamine diphosphate biosynthesis [Term] id: UPa:ULS00060 name: thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04327 ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_input_compound UPa:UPC04327 {cardinality="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_input_compound UPa:UPC04752 {cardinality="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: has_input_compound UPa:UPC04752 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: has_output_compound UPa:UPC01081 ! thiamine phosphate relationship: has_output_compound UPa:UPC01081 {cardinality="1"} ! thiamine phosphate relationship: part_of UPa:UPA00060 ! thiamine diphosphate biosynthesis relationship: part_of UPa:UPA00060 {cardinality="1"} ! thiamine diphosphate biosynthesis [Term] id: UPa:ULS00061 name: acetyl-CoA from myo-inositol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol relationship: has_input_compound UPa:UPC00137 ! myo-inositol relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: part_of UPa:UPA00076 ! myo-inositol degradation into acetyl-CoA relationship: part_of UPa:UPA00076 {cardinality="1"} ! myo-inositol degradation into acetyl-CoA [Term] id: UPa:ULS00062 name: 4-aminobenzoate from chorismate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: has_input_compound UPa:UPC00251 ! chorismate relationship: has_output_compound UPa:UPC00568 {cardinality="1"} ! 4-aminobenzoate relationship: has_output_compound UPa:UPC00568 ! 4-aminobenzoate relationship: part_of UPa:UPA00077 ! tetrahydrofolate biosynthesis relationship: part_of UPa:UPA00077 {cardinality="1"} ! tetrahydrofolate biosynthesis [Term] id: UPa:ULS00063 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04895 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate relationship: has_input_compound UPa:UPC04895 ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC04807 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: has_output_compound UPa:UPC04807 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: part_of UPa:UPA00077 ! tetrahydrofolate biosynthesis relationship: part_of UPa:UPA00077 {cardinality="1"} ! tetrahydrofolate biosynthesis [Term] id: UPa:ULS00064 name: 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00568 {cardinality="1"} ! 4-aminobenzoate relationship: has_input_compound UPa:UPC00568 ! 4-aminobenzoate relationship: has_input_compound UPa:UPC04807 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: has_input_compound UPa:UPC04807 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: has_output_compound UPa:UPC00415 {cardinality="1"} ! 7,8-dihydrofolate relationship: has_output_compound UPa:UPC00415 ! 7,8-dihydrofolate relationship: part_of UPa:UPA00077 ! tetrahydrofolate biosynthesis relationship: part_of UPa:UPA00077 {cardinality="1"} ! tetrahydrofolate biosynthesis [Term] id: UPa:ULS00067 name: formate from 10-formyl-5,6,7,8-tetrahydrofolate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00234 {cardinality="1"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC00234 ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: part_of UPa:UPA00074 {cardinality="1"} ! IMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00074 ! IMP biosynthesis via de novo pathway [Term] id: UPa:ULS00068 name: carbamoyl phosphate from bicarbonate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_output_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00169 ! carbamoyl phosphate relationship: part_of UPa:UPA00068 {cardinality="1"} ! L-arginine biosynthesis relationship: part_of UPa:UPA00068 ! L-arginine biosynthesis [Term] id: UPa:ULS00069 name: D-glucuronate from myo-inositol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol relationship: has_input_compound UPa:UPC00137 ! myo-inositol relationship: has_output_compound UPa:UPC00191 ! D-glucuronate relationship: has_output_compound UPa:UPC00191 {cardinality="1"} ! D-glucuronate relationship: part_of UPa:UPA00111 ! myo-inositol degradation into D-glucuronate relationship: part_of UPa:UPA00111 {cardinality="1"} ! myo-inositol degradation into D-glucuronate [Term] id: UPa:ULS00070 name: 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: has_input_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UPA00087 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis relationship: part_of UPa:UPA00087 ! 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis [Term] id: UPa:ULS00071 name: 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: has_input_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UPA00087 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis relationship: part_of UPa:UPA00087 ! 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis [Term] id: UPa:ULS00072 name: 3-dehydroquinate from D-quinate (NAD(+) route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00296 {cardinality="1"} ! D-quinate relationship: has_input_compound UPa:UPC00296 ! D-quinate relationship: has_output_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00944 ! 3-dehydroquinate relationship: part_of UPa:UPA00088 ! 3,4-dihydroxybenzoate biosynthesis relationship: part_of UPa:UPA00088 {cardinality="1"} ! 3,4-dihydroxybenzoate biosynthesis [Term] id: UPa:ULS00073 name: 3-dehydroquinate from D-quinate (PQQ route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00296 {cardinality="1"} ! D-quinate relationship: has_input_compound UPa:UPC00296 ! D-quinate relationship: has_output_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00944 ! 3-dehydroquinate relationship: part_of UPa:UPA00088 ! 3,4-dihydroxybenzoate biosynthesis relationship: part_of UPa:UPA00088 {cardinality="1"} ! 3,4-dihydroxybenzoate biosynthesis [Term] id: UPa:ULS00074 name: 3,4-dihydroxybenzoate from 3-dehydroquinate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00944 ! 3-dehydroquinate relationship: has_input_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: part_of UPa:UPA00088 ! 3,4-dihydroxybenzoate biosynthesis relationship: part_of UPa:UPA00088 {cardinality="1"} ! 3,4-dihydroxybenzoate biosynthesis [Term] id: UPa:ULS00075 name: D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00031 {cardinality="1"} ! D-glucose relationship: has_input_compound UPa:UPC00031 ! D-glucose relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UPA00109 ! glycolysis relationship: part_of UPa:UPA00109 {cardinality="1"} ! glycolysis [Term] id: UPa:ULS00076 name: D-glyceraldehyde 3-phosphate from glycerone phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_input_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UPA00109 ! glycolysis relationship: part_of UPa:UPA00109 {cardinality="1"} ! glycolysis [Term] id: UPa:ULS00077 name: pyruvate from D-glyceraldehyde 3-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: part_of UPa:UPA00109 ! glycolysis relationship: part_of UPa:UPA00109 {cardinality="1"} ! glycolysis [Term] id: UPa:ULS00078 name: GDP-L-fucose from GDP-alpha-D-mannose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00325 ! GDP-L-fucose relationship: has_output_compound UPa:UPC00325 {cardinality="1"} ! GDP-L-fucose relationship: part_of UPa:UPA00128 ! GDP-L-fucose biosynthesis via de novo pathway relationship: part_of UPa:UPA00128 {cardinality="1"} ! GDP-L-fucose biosynthesis via de novo pathway [Term] id: UPa:ULS00079 name: 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC11544 ! 2-(alpha-D-mannosyl)-D-glycerate relationship: has_output_compound UPa:UPC11544 {cardinality="1"} ! 2-(alpha-D-mannosyl)-D-glycerate relationship: part_of UPa:UPA00130 ! 2-(alpha-D-mannosyl)-D-glycerate biosynthesis relationship: part_of UPa:UPA00130 {cardinality="1"} ! 2-(alpha-D-mannosyl)-D-glycerate biosynthesis [Term] id: UPa:ULS00080 name: L-asparagine from L-aspartate (ammonia route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00152 {cardinality="1"} ! L-asparagine relationship: has_output_compound UPa:UPC00152 ! L-asparagine relationship: part_of UPa:UPA00134 {cardinality="1"} ! L-asparagine biosynthesis relationship: part_of UPa:UPA00134 ! L-asparagine biosynthesis [Term] id: UPa:ULS00081 name: L-asparagine from L-aspartate (L-Gln route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00152 ! L-asparagine relationship: has_output_compound UPa:UPC00152 {cardinality="1"} ! L-asparagine relationship: part_of UPa:UPA00134 {cardinality="1"} ! L-asparagine biosynthesis relationship: part_of UPa:UPA00134 ! L-asparagine biosynthesis [Term] id: UPa:ULS00082 name: L-serine from 3-phospho-D-glycerate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: has_input_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00065 ! L-serine relationship: has_output_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: part_of UPa:UPA00135 {cardinality="1"} ! L-serine biosynthesis relationship: part_of UPa:UPA00135 ! L-serine biosynthesis [Term] id: UPa:ULS00083 name: L-cysteine from L-serine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_output_compound UPa:UPC00097 ! L-cysteine relationship: has_output_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: part_of UPa:UPA00136 {cardinality="1"} ! L-cysteine biosynthesis relationship: part_of UPa:UPA00136 ! L-cysteine biosynthesis [Term] id: UPa:ULS00084 name: L-cysteine from L-homocysteine and L-serine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_input_compound UPa:UPC00155 ! L-homocysteine relationship: has_output_compound UPa:UPC00097 ! L-cysteine relationship: has_output_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: part_of UPa:UPA00136 {cardinality="1"} ! L-cysteine biosynthesis relationship: part_of UPa:UPA00136 ! L-cysteine biosynthesis [Term] id: UPa:ULS00085 name: prephenate from chorismate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00251 ! chorismate relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: has_output_compound UPa:UPC00254 ! prephenate relationship: has_output_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: part_of UPa:UPA00120 {cardinality="1"} ! prephenate biosynthesis relationship: part_of UPa:UPA00120 ! prephenate biosynthesis [Term] id: UPa:ULS00086 name: sulfite from sulfate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00059 {cardinality="1"} ! sulfate relationship: has_input_compound UPa:UPC00059 ! sulfate relationship: has_output_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: part_of UPa:UPA00140 {cardinality="1"} ! hydrogen sulfide biosynthesis relationship: part_of UPa:UPA00140 ! hydrogen sulfide biosynthesis [Term] id: UPa:ULS00087 name: hydrogen sulfide from sulfite (NADPH route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_input_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_output_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: part_of UPa:UPA00140 {cardinality="1"} ! hydrogen sulfide biosynthesis relationship: part_of UPa:UPA00140 ! hydrogen sulfide biosynthesis [Term] id: UPa:ULS00088 name: hydrogen sulfide from sulfite (ferredoxin route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_input_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC00283 ! hydrogen sulfide relationship: has_output_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: part_of UPa:UPA00140 {cardinality="1"} ! hydrogen sulfide biosynthesis relationship: part_of UPa:UPA00140 ! hydrogen sulfide biosynthesis [Term] id: UPa:ULS00089 name: glutathione from L-cysteine and L-glutamate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_output_compound UPa:UPC00051 ! glutathione relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione relationship: part_of UPa:UPA00142 {cardinality="1"} ! glutathione biosynthesis relationship: part_of UPa:UPA00142 ! glutathione biosynthesis [Term] id: UPa:ULS00090 name: precorrin-2 from uroporphyrinogen III namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01051 {cardinality="1"} ! uroporphyrinogen III relationship: has_input_compound UPa:UPC01051 ! uroporphyrinogen III relationship: has_output_compound UPa:UPC02463 ! precorrin-2 relationship: has_output_compound UPa:UPC02463 {cardinality="1"} ! precorrin-2 relationship: part_of UPa:UPA00148 ! adenosylcobalamin biosynthesis relationship: part_of UPa:UPA00148 {cardinality="1"} ! adenosylcobalamin biosynthesis relationship: part_of UPa:UPA00262 {cardinality="1"} ! siroheme biosynthesis relationship: part_of UPa:UPA00262 ! siroheme biosynthesis [Term] id: UPa:ULS00091 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC02463 {cardinality="1"} ! precorrin-2 relationship: has_input_compound UPa:UPC02463 ! precorrin-2 relationship: has_output_compound UPa:UPC06504 ! cob(II)yrinate a,c-diamide relationship: has_output_compound UPa:UPC06504 {cardinality="1"} ! cob(II)yrinate a,c-diamide relationship: part_of UPa:UPA00148 ! adenosylcobalamin biosynthesis relationship: part_of UPa:UPA00148 {cardinality="1"} ! adenosylcobalamin biosynthesis [Term] id: UPa:ULS00092 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC05778 {cardinality="1"} ! sirohydrochlorin relationship: has_input_compound UPa:UPC05778 ! sirohydrochlorin relationship: has_output_compound UPa:UPC06504 ! cob(II)yrinate a,c-diamide relationship: has_output_compound UPa:UPC06504 {cardinality="1"} ! cob(II)yrinate a,c-diamide relationship: part_of UPa:UPA00148 ! adenosylcobalamin biosynthesis relationship: part_of UPa:UPA00148 {cardinality="1"} ! adenosylcobalamin biosynthesis [Term] id: UPa:ULS00093 name: adenosylcobalamin from cob(II)yrinate a,c-diamide namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC06504 {cardinality="2"} ! cob(II)yrinate a,c-diamide relationship: has_input_compound UPa:UPC06504 ! cob(II)yrinate a,c-diamide relationship: has_output_compound UPa:UPC00194 ! adenosylcobalamin relationship: has_output_compound UPa:UPC00194 {cardinality="1"} ! adenosylcobalamin relationship: part_of UPa:UPA00148 ! adenosylcobalamin biosynthesis relationship: part_of UPa:UPA00148 {cardinality="1"} ! adenosylcobalamin biosynthesis [Term] id: UPa:ULS00094 name: penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC00183 {cardinality="1"} ! L-valine relationship: has_input_compound UPa:UPC00183 ! L-valine relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC05551 ! penicillin G relationship: has_output_compound UPa:UPC05551 {cardinality="1"} ! penicillin G relationship: part_of UPa:UPA00149 ! penicillin G biosynthesis relationship: part_of UPa:UPA00149 {cardinality="1"} ! penicillin G biosynthesis [Term] id: UPa:ULS00095 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC06662 ! clavulanate relationship: has_output_compound UPa:UPC06662 {cardinality="1"} ! clavulanate relationship: part_of UPa:UPA00112 ! clavulanate biosynthesis relationship: part_of UPa:UPA00112 {cardinality="1"} ! clavulanate biosynthesis [Term] id: UPa:ULS00096 name: 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC06588 {cardinality="1"} ! biphenyl relationship: has_input_compound UPa:UPC06588 ! biphenyl relationship: has_output_compound UPa:UPC00180 ! benzoate relationship: has_output_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: has_output_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate relationship: part_of UPa:UPA00155 ! biphenyl degradation relationship: part_of UPa:UPA00155 {cardinality="1"} ! biphenyl degradation [Term] id: UPa:ULS00097 name: catechol from benzoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: has_input_compound UPa:UPC00180 ! benzoate relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: has_output_compound UPa:UPC00090 ! catechol relationship: part_of UPa:UPA00156 ! benzoate degradation via hydroxylation relationship: part_of UPa:UPA00156 {cardinality="1"} ! benzoate degradation via hydroxylation [Term] id: UPa:ULS00098 name: 3,4-dihydroxybenzoate from benzoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: has_input_compound UPa:UPC00180 ! benzoate relationship: has_output_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: part_of UPa:UPA00156 ! benzoate degradation via hydroxylation relationship: part_of UPa:UPA00156 {cardinality="1"} ! benzoate degradation via hydroxylation [Term] id: UPa:ULS00099 name: 5-oxo-4,5-dihydro-2-furylacetate from catechol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: has_input_compound UPa:UPC00090 ! catechol relationship: has_output_compound UPa:UPC03586 {cardinality="1"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_output_compound UPa:UPC03586 ! 5-oxo-4,5-dihydro-2-furylacetate relationship: part_of UPa:UPA00157 ! beta-ketoadipate pathway relationship: part_of UPa:UPA00157 {cardinality="1"} ! beta-ketoadipate pathway [Term] id: UPa:ULS00100 name: 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03586 {cardinality="1"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_input_compound UPa:UPC03586 ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_output_compound UPa:UPC00846 ! 3-oxoadipate relationship: has_output_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate relationship: part_of UPa:UPA00157 ! beta-ketoadipate pathway relationship: part_of UPa:UPA00157 {cardinality="1"} ! beta-ketoadipate pathway [Term] id: UPa:ULS00101 name: acetyl-CoA and succinyl-CoA from 3-oxoadipate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate relationship: has_input_compound UPa:UPC00846 ! 3-oxoadipate relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: part_of UPa:UPA00157 ! beta-ketoadipate pathway relationship: part_of UPa:UPA00157 {cardinality="1"} ! beta-ketoadipate pathway [Term] id: UPa:ULS00102 name: 3-carboxy-cis,cis-muconate from 3,4-dihydroxybenzoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: has_input_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC01163 ! 3-carboxy-cis,cis-muconate relationship: has_output_compound UPa:UPC01163 {cardinality="1"} ! 3-carboxy-cis,cis-muconate relationship: part_of UPa:UPA00157 ! beta-ketoadipate pathway relationship: part_of UPa:UPA00157 {cardinality="1"} ! beta-ketoadipate pathway [Term] id: UPa:ULS00103 name: 3-oxoadipate from 3,4-dihydroxybenzoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: has_input_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00846 ! 3-oxoadipate relationship: has_output_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate relationship: part_of UPa:UPA00157 ! beta-ketoadipate pathway relationship: part_of UPa:UPA00157 {cardinality="1"} ! beta-ketoadipate pathway [Term] id: UPa:ULS00104 name: betaine from glycine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00719 {cardinality="1"} ! betaine relationship: has_output_compound UPa:UPC00719 ! betaine relationship: part_of UPa:UPA00530 ! betaine biosynthesis via glycine pathway relationship: part_of UPa:UPA00530 {cardinality="1"} ! betaine biosynthesis via glycine pathway [Term] id: UPa:ULS00105 name: UDP from UMP (UMK/CMK route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00105 ! UMP relationship: has_input_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: part_of UPa:UPA00159 ! CTP biosynthesis via de novo pathway relationship: part_of UPa:UPA00159 {cardinality="1"} ! CTP biosynthesis via de novo pathway [Term] id: UPa:ULS00106 name: UDP from UMP (UMPK route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00105 ! UMP relationship: has_input_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: has_output_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: part_of UPa:UPA00159 ! CTP biosynthesis via de novo pathway relationship: part_of UPa:UPA00159 {cardinality="1"} ! CTP biosynthesis via de novo pathway [Term] id: UPa:ULS00107 name: CTP from UDP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_input_compound UPa:UPC00015 ! UDP relationship: has_output_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_output_compound UPa:UPC00063 ! CTP relationship: part_of UPa:UPA00159 ! CTP biosynthesis via de novo pathway relationship: part_of UPa:UPA00159 {cardinality="1"} ! CTP biosynthesis via de novo pathway [Term] id: UPa:ULS00108 name: CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC01187 {cardinality="1"} ! 3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC01187 ! 3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC04121 ! CMP-3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC04121 {cardinality="1"} ! CMP-3-deoxy-D-manno-octulosonate relationship: part_of UPa:UPA00358 ! CMP-3-deoxy-D-manno-octulosonate biosynthesis relationship: part_of UPa:UPA00358 {cardinality="1"} ! CMP-3-deoxy-D-manno-octulosonate biosynthesis [Term] id: UPa:ULS00109 name: L-glutamate and succinate from L-arginine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_output_compound UPa:UPC00025 {cardinality="2"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: part_of UPa:UPA00185 ! L-arginine degradation via AST pathway relationship: part_of UPa:UPA00185 {cardinality="1"} ! L-arginine degradation via AST pathway [Term] id: UPa:ULS00110 name: agmatine from L-arginine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_output_compound UPa:UPC00179 ! agmatine relationship: has_output_compound UPa:UPC00179 {cardinality="1"} ! agmatine relationship: part_of UPa:UPA00186 {cardinality="1"} ! agmatine biosynthesis relationship: part_of UPa:UPA00186 ! agmatine biosynthesis [Term] id: UPa:ULS00111 name: N-carbamoylputrescine from agmatine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00179 {cardinality="1"} ! agmatine relationship: has_input_compound UPa:UPC00179 ! agmatine relationship: has_output_compound UPa:UPC00436 ! N-carbamoylputrescine relationship: has_output_compound UPa:UPC00436 {cardinality="1"} ! N-carbamoylputrescine relationship: part_of UPa:UPA00534 ! putrescine biosynthesis via agmatine pathway relationship: part_of UPa:UPA00534 {cardinality="1"} ! putrescine biosynthesis via agmatine pathway [Term] id: UPa:ULS00112 name: putrescine from agmatine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00179 {cardinality="1"} ! agmatine relationship: has_input_compound UPa:UPC00179 ! agmatine relationship: has_output_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: part_of UPa:UPA00534 ! putrescine biosynthesis via agmatine pathway relationship: part_of UPa:UPA00534 {cardinality="1"} ! putrescine biosynthesis via agmatine pathway [Term] id: UPa:ULS00113 name: putrescine from L-ornithine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: part_of UPa:UPA00535 ! putrescine biosynthesis via L-ornithine pathway relationship: part_of UPa:UPA00535 {cardinality="1"} ! putrescine biosynthesis via L-ornithine pathway [Term] id: UPa:ULS00114 name: 4-aminobutanal from putrescine (amine oxidase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00555 ! 4-aminobutanal relationship: has_output_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal relationship: part_of UPa:UPA00188 {cardinality="1"} ! putrescine degradation relationship: part_of UPa:UPA00188 ! putrescine degradation [Term] id: UPa:ULS00115 name: 4-aminobutanal from putrescine (transaminase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00555 ! 4-aminobutanal relationship: has_output_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal relationship: part_of UPa:UPA00188 {cardinality="1"} ! putrescine degradation relationship: part_of UPa:UPA00188 ! putrescine degradation [Term] id: UPa:ULS00117 name: XMP from IMP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: has_input_compound UPa:UPC00130 ! IMP relationship: has_output_compound UPa:UPC00655 ! XMP relationship: has_output_compound UPa:UPC00655 {cardinality="1"} ! XMP relationship: part_of UPa:UPA00601 ! XMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00601 {cardinality="1"} ! XMP biosynthesis via de novo pathway [Term] id: UPa:ULS00118 name: GMP from XMP (L-Gln route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00655 ! XMP relationship: has_input_compound UPa:UPC00655 {cardinality="1"} ! XMP relationship: has_output_compound UPa:UPC00144 ! GMP relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: part_of UPa:UPA00189 {cardinality="1"} ! GMP biosynthesis relationship: part_of UPa:UPA00189 ! GMP biosynthesis [Term] id: UPa:ULS00119 name: GMP from XMP (ammonia route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00655 ! XMP relationship: has_input_compound UPa:UPC00655 {cardinality="1"} ! XMP relationship: has_output_compound UPa:UPC00144 ! GMP relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: part_of UPa:UPA00189 {cardinality="1"} ! GMP biosynthesis relationship: part_of UPa:UPA00189 ! GMP biosynthesis [Term] id: UPa:ULS00120 name: pyridoxal 5'-phosphate from pyridoxal namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: has_input_compound UPa:UPC00250 ! pyridoxal relationship: has_output_compound UPa:UPC00018 ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate relationship: part_of UPa:UPA00190 ! B6 vitamer interconversion relationship: part_of UPa:UPA00190 {cardinality="1"} ! B6 vitamer interconversion [Term] id: UPa:ULS00121 name: pyridoxamine 5'-phosphate from pyridoxamine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00534 {cardinality="1"} ! pyridoxamine relationship: has_input_compound UPa:UPC00534 ! pyridoxamine relationship: has_output_compound UPa:UPC00647 ! pyridoxamine 5'-phosphate relationship: has_output_compound UPa:UPC00647 {cardinality="1"} ! pyridoxamine 5'-phosphate relationship: part_of UPa:UPA00190 ! B6 vitamer interconversion relationship: part_of UPa:UPA00190 {cardinality="1"} ! B6 vitamer interconversion [Term] id: UPa:ULS00122 name: pyridoxine 5'-phosphate from pyridoxine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00314 ! pyridoxine relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine relationship: has_output_compound UPa:UPC00627 ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate relationship: part_of UPa:UPA00190 ! B6 vitamer interconversion relationship: part_of UPa:UPA00190 {cardinality="1"} ! B6 vitamer interconversion [Term] id: UPa:ULS00123 name: pyridoxal from pyridoxal 5'-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate relationship: has_input_compound UPa:UPC00018 ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00250 ! pyridoxal relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: part_of UPa:UPA00190 ! B6 vitamer interconversion relationship: part_of UPa:UPA00190 {cardinality="1"} ! B6 vitamer interconversion [Term] id: UPa:ULS00124 name: pyridoxamine from pyridoxamine 5'-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00647 {cardinality="1"} ! pyridoxamine 5'-phosphate relationship: has_input_compound UPa:UPC00647 ! pyridoxamine 5'-phosphate relationship: has_output_compound UPa:UPC00534 {cardinality="1"} ! pyridoxamine relationship: has_output_compound UPa:UPC00534 ! pyridoxamine relationship: part_of UPa:UPA00190 ! B6 vitamer interconversion relationship: part_of UPa:UPA00190 {cardinality="1"} ! B6 vitamer interconversion [Term] id: UPa:ULS00125 name: pyridoxine from pyridoxine 5'-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate relationship: has_input_compound UPa:UPC00627 ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00314 ! pyridoxine relationship: has_output_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine relationship: part_of UPa:UPA00190 ! B6 vitamer interconversion relationship: part_of UPa:UPA00190 {cardinality="1"} ! B6 vitamer interconversion [Term] id: UPa:ULS00126 name: pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00647 {cardinality="1"} ! pyridoxamine 5'-phosphate relationship: has_input_compound UPa:UPC00647 ! pyridoxamine 5'-phosphate relationship: has_output_compound UPa:UPC00018 ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate relationship: part_of UPa:UPA00190 ! B6 vitamer interconversion relationship: part_of UPa:UPA00190 {cardinality="1"} ! B6 vitamer interconversion [Term] id: UPa:ULS00127 name: pyridoxal 5'-phosphate from pyridoxine 5'-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate relationship: has_input_compound UPa:UPC00627 ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00018 ! pyridoxal 5'-phosphate relationship: part_of UPa:UPA00190 ! B6 vitamer interconversion relationship: part_of UPa:UPA00190 {cardinality="1"} ! B6 vitamer interconversion [Term] id: UPa:ULS00128 name: pyridoxal from pyridoxamine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00534 ! pyridoxamine relationship: has_input_compound UPa:UPC00534 {cardinality="1"} ! pyridoxamine relationship: has_output_compound UPa:UPC00250 ! pyridoxal relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: part_of UPa:UPA00192 ! B6 vitamer degradation relationship: part_of UPa:UPA00192 {cardinality="1"} ! B6 vitamer degradation [Term] id: UPa:ULS00129 name: pyridoxal from pyridoxine (dehydrogenase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00314 ! pyridoxine relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: has_output_compound UPa:UPC00250 ! pyridoxal relationship: part_of UPa:UPA00192 ! B6 vitamer degradation relationship: part_of UPa:UPA00192 {cardinality="1"} ! B6 vitamer degradation [Term] id: UPa:ULS00130 name: 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01163 {cardinality="1"} ! 3-carboxy-cis,cis-muconate relationship: has_input_compound UPa:UPC01163 ! 3-carboxy-cis,cis-muconate relationship: has_output_compound UPa:UPC03586 {cardinality="1"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_output_compound UPa:UPC03586 ! 5-oxo-4,5-dihydro-2-furylacetate relationship: part_of UPa:UPA00157 {cardinality="1"} ! beta-ketoadipate pathway relationship: part_of UPa:UPA00157 ! beta-ketoadipate pathway [Term] id: UPa:ULS00131 name: 3-carboxy-cis,cis-muconate from 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04553 {cardinality="1"} ! 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_input_compound UPa:UPC04553 ! 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_output_compound UPa:UPC01163 ! 3-carboxy-cis,cis-muconate relationship: has_output_compound UPa:UPC01163 {cardinality="1"} ! 3-carboxy-cis,cis-muconate relationship: part_of UPa:UPA00157 {cardinality="1"} ! beta-ketoadipate pathway relationship: part_of UPa:UPA00157 ! beta-ketoadipate pathway [Term] id: UPa:ULS00132 name: pyridoxine 5'-phosphate from D-erythrose 4-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00279 ! D-erythrose 4-phosphate relationship: has_input_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00627 ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate relationship: part_of UPa:UPA00244 ! pyridoxine 5'-phosphate biosynthesis relationship: part_of UPa:UPA00244 {cardinality="1"} ! pyridoxine 5'-phosphate biosynthesis [Term] id: UPa:ULS00133 name: 4-aminobutanoate from 4-aminobutanal namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal relationship: has_input_compound UPa:UPC00555 ! 4-aminobutanal relationship: has_output_compound UPa:UPC00334 {cardinality="1"} ! 4-aminobutanoate relationship: has_output_compound UPa:UPC00334 ! 4-aminobutanoate relationship: part_of UPa:UPA00188 {cardinality="1"} ! putrescine degradation relationship: part_of UPa:UPA00188 ! putrescine degradation [Term] id: UPa:ULS00134 name: succinate semialdehyde from 4-aminobutanoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00334 {cardinality="1"} ! 4-aminobutanoate relationship: has_input_compound UPa:UPC00334 ! 4-aminobutanoate relationship: has_output_compound UPa:UPC00232 ! succinate semialdehyde relationship: has_output_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde relationship: part_of UPa:UPA00188 {cardinality="1"} ! putrescine degradation relationship: part_of UPa:UPA00188 ! putrescine degradation [Term] id: UPa:ULS00135 name: 1,3-diaminopropane and 4-aminobutanal from spermidine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00315 {cardinality="1"} ! spermidine relationship: has_input_compound UPa:UPC00315 ! spermidine relationship: has_output_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal relationship: has_output_compound UPa:UPC00555 ! 4-aminobutanal relationship: has_output_compound UPa:UPC00986 ! 1,3-diaminopropane relationship: has_output_compound UPa:UPC00986 {cardinality="1"} ! 1,3-diaminopropane relationship: part_of UPa:UPA00250 ! spermidine degradation relationship: part_of UPa:UPA00250 {cardinality="1"} ! spermidine degradation [Term] id: UPa:ULS00136 name: spermidine from putrescine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00315 ! spermidine relationship: has_output_compound UPa:UPC00315 {cardinality="1"} ! spermidine relationship: part_of UPa:UPA00248 ! spermidine biosynthesis relationship: part_of UPa:UPA00248 {cardinality="1"} ! spermidine biosynthesis [Term] id: UPa:ULS00137 name: spermine from spermidine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00315 {cardinality="1"} ! spermidine relationship: has_input_compound UPa:UPC00315 ! spermidine relationship: has_output_compound UPa:UPC00750 ! spermine relationship: has_output_compound UPa:UPC00750 {cardinality="1"} ! spermine relationship: part_of UPa:UPA00249 ! spermine biosynthesis relationship: part_of UPa:UPA00249 {cardinality="1"} ! spermine biosynthesis [Term] id: UPa:ULS00138 name: 5-aminolevulinate from L-glutamyl-tRNA(Glu) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC02987 {cardinality="1"} ! L-glutamyl-tRNA(Glu) relationship: has_input_compound UPa:UPC02987 ! L-glutamyl-tRNA(Glu) relationship: has_output_compound UPa:UPC00430 ! 5-aminolevulinate relationship: has_output_compound UPa:UPC00430 {cardinality="1"} ! 5-aminolevulinate relationship: part_of UPa:UPA00251 ! protoporphyrin-IX biosynthesis relationship: part_of UPa:UPA00251 {cardinality="1"} ! protoporphyrin-IX biosynthesis [Term] id: UPa:ULS00139 name: protoporphyrinogen-IX from coproporphyrinogen-III (O2 route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03263 {cardinality="1"} ! coproporphyrinogen-III relationship: has_input_compound UPa:UPC03263 ! coproporphyrinogen-III relationship: has_output_compound UPa:UPC01079 ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC01079 {cardinality="1"} ! protoporphyrinogen-IX relationship: part_of UPa:UPA00251 ! protoporphyrin-IX biosynthesis relationship: part_of UPa:UPA00251 {cardinality="1"} ! protoporphyrin-IX biosynthesis [Term] id: UPa:ULS00140 name: protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03263 {cardinality="1"} ! coproporphyrinogen-III relationship: has_input_compound UPa:UPC03263 ! coproporphyrinogen-III relationship: has_output_compound UPa:UPC01079 ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC01079 {cardinality="1"} ! protoporphyrinogen-IX relationship: part_of UPa:UPA00251 ! protoporphyrin-IX biosynthesis relationship: part_of UPa:UPA00251 {cardinality="1"} ! protoporphyrin-IX biosynthesis [Term] id: UPa:ULS00141 name: protoporphyrin-IX from protoporphyrinogen-IX namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01079 {cardinality="1"} ! protoporphyrinogen-IX relationship: has_input_compound UPa:UPC01079 ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC02191 ! protoporphyrin-IX relationship: has_output_compound UPa:UPC02191 {cardinality="1"} ! protoporphyrin-IX relationship: part_of UPa:UPA00251 ! protoporphyrin-IX biosynthesis relationship: part_of UPa:UPA00251 {cardinality="1"} ! protoporphyrin-IX biosynthesis [Term] id: UPa:ULS00142 name: iminoaspartate from L-aspartate (oxidase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC05840 ! iminoaspartate relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate relationship: part_of UPa:UPA00253 ! NAD(+) biosynthesis relationship: part_of UPa:UPA00253 {cardinality="1"} ! NAD(+) biosynthesis [Term] id: UPa:ULS00143 name: quinolinate from L-kynurenine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine relationship: has_input_compound UPa:UPC00328 ! L-kynurenine relationship: has_output_compound UPa:UPC03722 ! quinolinate relationship: has_output_compound UPa:UPC03722 {cardinality="1"} ! quinolinate relationship: part_of UPa:UPA00253 {cardinality="1"} ! NAD(+) biosynthesis relationship: part_of UPa:UPA00253 ! NAD(+) biosynthesis [Term] id: UPa:ULS00144 name: nicotinate D-ribonucleotide from quinolinate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03722 ! quinolinate relationship: has_input_compound UPa:UPC03722 {cardinality="1"} ! quinolinate relationship: has_output_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide relationship: has_output_compound UPa:UPC01185 ! nicotinate D-ribonucleotide relationship: part_of UPa:UPA00253 {cardinality="1"} ! NAD(+) biosynthesis relationship: part_of UPa:UPA00253 ! NAD(+) biosynthesis [Term] id: UPa:ULS00145 name: NAD(+) from deamido-NAD(+) (ammonia route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00857 ! deamido-NAD(+) relationship: has_input_compound UPa:UPC00857 {cardinality="1"} ! deamido-NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: part_of UPa:UPA00253 {cardinality="1"} ! NAD(+) biosynthesis relationship: part_of UPa:UPA00253 ! NAD(+) biosynthesis [Term] id: UPa:ULS00146 name: NAD(+) from deamido-NAD(+) (L-Gln route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00857 {cardinality="1"} ! deamido-NAD(+) relationship: has_input_compound UPa:UPC00857 ! deamido-NAD(+) relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: part_of UPa:UPA00253 {cardinality="1"} ! NAD(+) biosynthesis relationship: part_of UPa:UPA00253 ! NAD(+) biosynthesis [Term] id: UPa:ULS00147 name: AMP from IMP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00130 ! IMP relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: part_of UPa:UPA00075 {cardinality="1"} ! AMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00075 ! AMP biosynthesis via de novo pathway [Term] id: UPa:ULS00148 name: acetoacetate and fumarate from L-phenylalanine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: has_output_compound UPa:UPC00164 ! acetoacetate relationship: has_output_compound UPa:UPC00164 {cardinality="1"} ! acetoacetate relationship: part_of UPa:UPA00139 ! L-phenylalanine degradation relationship: part_of UPa:UPA00139 {cardinality="1"} ! L-phenylalanine degradation [Term] id: UPa:ULS00149 name: L-arogenate from prephenate (L-Asp route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_output_compound UPa:UPC00826 ! L-arogenate relationship: has_output_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: part_of UPa:UPA00121 ! L-phenylalanine biosynthesis relationship: part_of UPa:UPA00121 {cardinality="1"} ! L-phenylalanine biosynthesis relationship: part_of UPa:UPA00122 ! L-tyrosine biosynthesis relationship: part_of UPa:UPA00122 {cardinality="1"} ! L-tyrosine biosynthesis [Term] id: UPa:ULS00150 name: L-arogenate from prephenate (L-Glu route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_output_compound UPa:UPC00826 ! L-arogenate relationship: has_output_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: part_of UPa:UPA00121 ! L-phenylalanine biosynthesis relationship: part_of UPa:UPA00121 {cardinality="1"} ! L-phenylalanine biosynthesis relationship: part_of UPa:UPA00122 ! L-tyrosine biosynthesis relationship: part_of UPa:UPA00122 {cardinality="1"} ! L-tyrosine biosynthesis [Term] id: UPa:ULS00151 name: L-phenylalanine from L-arogenate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_input_compound UPa:UPC00826 ! L-arogenate relationship: has_output_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: part_of UPa:UPA00121 ! L-phenylalanine biosynthesis relationship: part_of UPa:UPA00121 {cardinality="1"} ! L-phenylalanine biosynthesis [Term] id: UPa:ULS00152 name: phenylpyruvate from prephenate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: has_output_compound UPa:UPC00166 ! phenylpyruvate relationship: has_output_compound UPa:UPC00166 {cardinality="1"} ! phenylpyruvate relationship: part_of UPa:UPA00121 ! L-phenylalanine biosynthesis relationship: part_of UPa:UPA00121 {cardinality="1"} ! L-phenylalanine biosynthesis [Term] id: UPa:ULS00153 name: L-phenylalanine from phenylpyruvate (PDH route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00166 {cardinality="1"} ! phenylpyruvate relationship: has_input_compound UPa:UPC00166 ! phenylpyruvate relationship: has_output_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: part_of UPa:UPA00121 ! L-phenylalanine biosynthesis relationship: part_of UPa:UPA00121 {cardinality="1"} ! L-phenylalanine biosynthesis [Term] id: UPa:ULS00154 name: L-phenylalanine from phenylpyruvate (ArAT route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00166 {cardinality="1"} ! phenylpyruvate relationship: has_input_compound UPa:UPC00166 ! phenylpyruvate relationship: has_output_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: part_of UPa:UPA00121 ! L-phenylalanine biosynthesis relationship: part_of UPa:UPA00121 {cardinality="1"} ! L-phenylalanine biosynthesis [Term] id: UPa:ULS00157 name: pimeloyl-CoA from pimelate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC02656 ! pimelate relationship: has_input_compound UPa:UPC02656 {cardinality="1"} ! pimelate relationship: has_output_compound UPa:UPC01063 {cardinality="1"} ! pimeloyl-CoA relationship: has_output_compound UPa:UPC01063 ! pimeloyl-CoA relationship: part_of UPa:UPA00078 ! biotin biosynthesis relationship: part_of UPa:UPA00078 {cardinality="1"} ! biotin biosynthesis relationship: part_of UPa:UPA00999 ! pimeloyl-CoA biosynthesis relationship: part_of UPa:UPA00999 {cardinality="1"} ! pimeloyl-CoA biosynthesis [Term] id: UPa:ULS00158 name: CoA from (R)-pantothenate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00864 {cardinality="1"} ! (R)-pantothenate relationship: has_input_compound UPa:UPC00864 ! (R)-pantothenate relationship: has_output_compound UPa:UPC00010 ! CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: part_of UPa:UPA00241 ! coenzyme A biosynthesis relationship: part_of UPa:UPA00241 {cardinality="1"} ! coenzyme A biosynthesis [Term] id: UPa:ULS00159 name: L-proline from L-ornithine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00148 ! L-proline relationship: has_output_compound UPa:UPC00148 {cardinality="1"} ! L-proline relationship: part_of UPa:UPA00098 ! L-proline biosynthesis relationship: part_of UPa:UPA00098 {cardinality="1"} ! L-proline biosynthesis [Term] id: UPa:ULS00160 name: L-glutamate 5-semialdehyde from L-ornithine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC01165 ! L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC01165 {cardinality="1"} ! L-glutamate 5-semialdehyde relationship: part_of UPa:UPA00098 {cardinality="1"} ! L-proline biosynthesis relationship: part_of UPa:UPA00098 ! L-proline biosynthesis [Term] id: UPa:ULS00161 name: L-glutamate 5-semialdehyde from L-glutamate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC01165 ! L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC01165 {cardinality="1"} ! L-glutamate 5-semialdehyde relationship: part_of UPa:UPA00098 {cardinality="1"} ! L-proline biosynthesis relationship: part_of UPa:UPA00098 ! L-proline biosynthesis [Term] id: UPa:ULS00162 name: L-proline from L-glutamate 5-semialdehyde namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01165 ! L-glutamate 5-semialdehyde relationship: has_input_compound UPa:UPC01165 {cardinality="1"} ! L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00148 {cardinality="1"} ! L-proline relationship: has_output_compound UPa:UPC00148 ! L-proline relationship: part_of UPa:UPA00098 {cardinality="1"} ! L-proline biosynthesis relationship: part_of UPa:UPA00098 ! L-proline biosynthesis [Term] id: UPa:ULS00163 name: N-acetylputrescine from putrescine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC02714 ! N-acetylputrescine relationship: has_output_compound UPa:UPC02714 {cardinality="1"} ! N-acetylputrescine relationship: part_of UPa:UPA00188 ! putrescine degradation relationship: part_of UPa:UPA00188 {cardinality="1"} ! putrescine degradation [Term] id: UPa:ULS00164 name: carbamoyl phosphate from L-arginine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_output_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: part_of UPa:UPA00254 ! L-arginine degradation via ADI pathway relationship: part_of UPa:UPA00254 {cardinality="1"} ! L-arginine degradation via ADI pathway [Term] id: UPa:ULS00165 name: (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00418 {cardinality="1"} ! (R)-mevalonate relationship: has_input_compound UPa:UPC00418 ! (R)-mevalonate relationship: has_output_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: part_of UPa:UPA00257 ! (R)-mevalonate degradation relationship: part_of UPa:UPA00257 {cardinality="1"} ! (R)-mevalonate degradation [Term] id: UPa:ULS00166 name: geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00235 {cardinality="1"} ! dimethylallyl diphosphate relationship: has_input_compound UPa:UPC00235 ! dimethylallyl diphosphate relationship: has_output_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00341 ! geranyl diphosphate relationship: part_of UPa:UPA00259 ! geranyl diphosphate biosynthesis relationship: part_of UPa:UPA00259 {cardinality="1"} ! geranyl diphosphate biosynthesis [Term] id: UPa:ULS00167 name: farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_output_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: part_of UPa:UPA00260 ! farnesyl diphosphate biosynthesis relationship: part_of UPa:UPA00260 {cardinality="1"} ! farnesyl diphosphate biosynthesis [Term] id: UPa:ULS00168 name: CO(2) and NH(3) from urea (urease route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_input_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="2"} ! NH(3) relationship: part_of UPa:UPA00258 ! urea degradation relationship: part_of UPa:UPA00258 {cardinality="1"} ! urea degradation [Term] id: UPa:ULS00169 name: CO(2) and NH(3) from urea (allophanate route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_input_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="2"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="2"} ! NH(3) relationship: part_of UPa:UPA00258 {cardinality="1"} ! urea degradation relationship: part_of UPa:UPA00258 ! urea degradation [Term] id: UPa:ULS00170 name: L-glutamate from L-proline namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00148 {cardinality="1"} ! L-proline relationship: has_input_compound UPa:UPC00148 ! L-proline relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: part_of UPa:UPA00261 {cardinality="1"} ! L-proline degradation into L-glutamate relationship: part_of UPa:UPA00261 ! L-proline degradation into L-glutamate [Term] id: UPa:ULS00171 name: 5-aminolevulinate from glycine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00430 {cardinality="1"} ! 5-aminolevulinate relationship: has_output_compound UPa:UPC00430 ! 5-aminolevulinate relationship: part_of UPa:UPA00251 {cardinality="1"} ! protoporphyrin-IX biosynthesis relationship: part_of UPa:UPA00251 ! protoporphyrin-IX biosynthesis [Term] id: UPa:ULS00172 name: coproporphyrinogen-III from 5-aminolevulinate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00430 {cardinality="2"} ! 5-aminolevulinate relationship: has_input_compound UPa:UPC00430 ! 5-aminolevulinate relationship: has_output_compound UPa:UPC03263 ! coproporphyrinogen-III relationship: has_output_compound UPa:UPC03263 {cardinality="1"} ! coproporphyrinogen-III relationship: part_of UPa:UPA00251 {cardinality="1"} ! protoporphyrin-IX biosynthesis relationship: part_of UPa:UPA00251 ! protoporphyrin-IX biosynthesis [Term] id: UPa:ULS00173 name: sirohydrochlorin from precorrin-2 namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC02463 ! precorrin-2 relationship: has_input_compound UPa:UPC02463 {cardinality="1"} ! precorrin-2 relationship: has_output_compound UPa:UPC05778 ! sirohydrochlorin relationship: has_output_compound UPa:UPC05778 {cardinality="1"} ! sirohydrochlorin relationship: part_of UPa:UPA00148 ! adenosylcobalamin biosynthesis relationship: part_of UPa:UPA00148 {cardinality="1"} ! adenosylcobalamin biosynthesis relationship: part_of UPa:UPA00262 {cardinality="1"} ! siroheme biosynthesis relationship: part_of UPa:UPA00262 ! siroheme biosynthesis [Term] id: UPa:ULS00174 name: siroheme from sirohydrochlorin namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC05778 {cardinality="1"} ! sirohydrochlorin relationship: has_input_compound UPa:UPC05778 ! sirohydrochlorin relationship: has_output_compound UPa:UPC00748 ! siroheme relationship: has_output_compound UPa:UPC00748 {cardinality="1"} ! siroheme relationship: part_of UPa:UPA00262 ! siroheme biosynthesis relationship: part_of UPa:UPA00262 {cardinality="1"} ! siroheme biosynthesis [Term] id: UPa:ULS00175 name: protoheme from protoporphyrin-IX namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC02191 {cardinality="1"} ! protoporphyrin-IX relationship: has_input_compound UPa:UPC02191 ! protoporphyrin-IX relationship: has_output_compound UPa:UPC00032 {cardinality="1"} ! protoheme relationship: has_output_compound UPa:UPC00032 ! protoheme relationship: part_of UPa:UPA00252 ! protoheme biosynthesis relationship: part_of UPa:UPA00252 {cardinality="1"} ! protoheme biosynthesis [Term] id: UPa:ULS00176 name: D-xylulose 5-phosphate from L-ascorbate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00072 ! L-ascorbate relationship: has_input_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: part_of UPa:UPA00263 ! L-ascorbate degradation relationship: part_of UPa:UPA00263 {cardinality="1"} ! L-ascorbate degradation [Term] id: UPa:ULS00177 name: L-ornithine and urea from L-arginine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_output_compound UPa:UPC00077 ! L-ornithine relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: part_of UPa:UPA00158 ! urea cycle relationship: part_of UPa:UPA00158 {cardinality="1"} ! urea cycle [Term] id: UPa:ULS00178 name: L-citrulline from L-ornithine and carbamoyl phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00077 ! L-ornithine relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_input_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00327 ! L-citrulline relationship: has_output_compound UPa:UPC00327 {cardinality="1"} ! L-citrulline relationship: part_of UPa:UPA00158 ! urea cycle relationship: part_of UPa:UPA00158 {cardinality="1"} ! urea cycle [Term] id: UPa:ULS00179 name: (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00327 {cardinality="1"} ! L-citrulline relationship: has_input_compound UPa:UPC00327 ! L-citrulline relationship: has_output_compound UPa:UPC03406 ! (N(omega)-L-arginino)succinate relationship: has_output_compound UPa:UPC03406 {cardinality="1"} ! (N(omega)-L-arginino)succinate relationship: part_of UPa:UPA00158 {cardinality="1"} ! urea cycle relationship: part_of UPa:UPA00158 ! urea cycle [Term] id: UPa:ULS00180 name: L-arginine and fumarate from (N(omega)-L-arginino)succinate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03406 {cardinality="1"} ! (N(omega)-L-arginino)succinate relationship: has_input_compound UPa:UPC03406 ! (N(omega)-L-arginino)succinate relationship: has_output_compound UPa:UPC00062 ! L-arginine relationship: has_output_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: part_of UPa:UPA00158 {cardinality="1"} ! urea cycle relationship: part_of UPa:UPA00158 ! urea cycle [Term] id: UPa:ULS00181 name: betaine from choline namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_output_compound UPa:UPC00719 ! betaine relationship: has_output_compound UPa:UPC00719 {cardinality="1"} ! betaine relationship: part_of UPa:UPA00529 {cardinality="1"} ! betaine biosynthesis via choline pathway relationship: part_of UPa:UPA00529 ! betaine biosynthesis via choline pathway [Term] id: UPa:ULS00182 name: betaine aldehyde from choline (cytochrome c reductase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde relationship: part_of UPa:UPA00529 {cardinality="1"} ! betaine biosynthesis via choline pathway relationship: part_of UPa:UPA00529 ! betaine biosynthesis via choline pathway [Term] id: UPa:ULS00183 name: betaine from betaine aldehyde namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: has_input_compound UPa:UPC00576 ! betaine aldehyde relationship: has_output_compound UPa:UPC00719 ! betaine relationship: has_output_compound UPa:UPC00719 {cardinality="1"} ! betaine relationship: part_of UPa:UPA00529 {cardinality="1"} ! betaine biosynthesis via choline pathway relationship: part_of UPa:UPA00529 ! betaine biosynthesis via choline pathway [Term] id: UPa:ULS00184 name: glycolate from 1,2-dichloroethane namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC06752 ! 1,2-dichloroethane relationship: has_input_compound UPa:UPC06752 {cardinality="1"} ! 1,2-dichloroethane relationship: has_output_compound UPa:UPC00160 {cardinality="1"} ! glycolate relationship: has_output_compound UPa:UPC00160 ! glycolate relationship: part_of UPa:UPA00265 ! 1,2-dichloroethane degradation relationship: part_of UPa:UPA00265 {cardinality="1"} ! 1,2-dichloroethane degradation [Term] id: UPa:ULS00185 name: catechol from benzene namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01407 {cardinality="1"} ! benzene relationship: has_input_compound UPa:UPC01407 ! benzene relationship: has_output_compound UPa:UPC00090 ! catechol relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: part_of UPa:UPA00272 ! benzene degradation relationship: part_of UPa:UPA00272 {cardinality="1"} ! benzene degradation [Term] id: UPa:ULS00186 name: 3-methylcatechol from toluene namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01455 {cardinality="1"} ! toluene relationship: has_input_compound UPa:UPC01455 ! toluene relationship: has_output_compound UPa:UPC02923 {cardinality="1"} ! 3-methylcatechol relationship: has_output_compound UPa:UPC02923 ! 3-methylcatechol relationship: part_of UPa:UPA00273 ! toluene degradation relationship: part_of UPa:UPA00273 {cardinality="1"} ! toluene degradation [Term] id: UPa:ULS00187 name: sarcosine from creatinine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00791 {cardinality="1"} ! creatinine relationship: has_input_compound UPa:UPC00791 ! creatinine relationship: has_output_compound UPa:UPC00213 ! sarcosine relationship: has_output_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: part_of UPa:UPA00274 ! creatinine degradation relationship: part_of UPa:UPA00274 {cardinality="1"} ! creatinine degradation [Term] id: UPa:ULS00188 name: 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC15556 ! 2-hydroxy-3-oxobutyl phosphate relationship: has_output_compound UPa:UPC15556 {cardinality="1"} ! 2-hydroxy-3-oxobutyl phosphate relationship: part_of UPa:UPA00275 ! riboflavin biosynthesis relationship: part_of UPa:UPA00275 {cardinality="1"} ! riboflavin biosynthesis [Term] id: UPa:ULS00189 name: 5-amino-6-(D-ribitylamino)uracil from GTP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_output_compound UPa:UPC04732 ! 5-amino-6-(D-ribitylamino)uracil relationship: has_output_compound UPa:UPC04732 {cardinality="1"} ! 5-amino-6-(D-ribitylamino)uracil relationship: part_of UPa:UPA00275 ! riboflavin biosynthesis relationship: part_of UPa:UPA00275 {cardinality="1"} ! riboflavin biosynthesis [Term] id: UPa:ULS00192 name: FMN from riboflavin (ATP route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00255 {cardinality="1"} ! riboflavin relationship: has_input_compound UPa:UPC00255 ! riboflavin relationship: has_output_compound UPa:UPC00061 {cardinality="1"} ! FMN relationship: has_output_compound UPa:UPC00061 ! FMN relationship: part_of UPa:UPA00276 {cardinality="1"} ! FMN biosynthesis relationship: part_of UPa:UPA00276 ! FMN biosynthesis [Term] id: UPa:ULS00193 name: FAD from FMN namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00061 {cardinality="1"} ! FMN relationship: has_input_compound UPa:UPC00061 ! FMN relationship: has_output_compound UPa:UPC00016 ! FAD relationship: has_output_compound UPa:UPC00016 {cardinality="1"} ! FAD relationship: part_of UPa:UPA00277 {cardinality="1"} ! FAD biosynthesis relationship: part_of UPa:UPA00277 ! FAD biosynthesis [Term] id: UPa:ULS00194 name: D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: part_of UPa:UPA00115 ! pentose phosphate pathway relationship: part_of UPa:UPA00115 {cardinality="1"} ! pentose phosphate pathway [Term] id: UPa:ULS00195 name: D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: part_of UPa:UPA00115 ! pentose phosphate pathway relationship: part_of UPa:UPA00115 {cardinality="1"} ! pentose phosphate pathway [Term] id: UPa:ULS00196 name: D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: part_of UPa:UPA00115 ! pentose phosphate pathway relationship: part_of UPa:UPA00115 {cardinality="1"} ! pentose phosphate pathway [Term] id: UPa:ULS00197 name: D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: has_input_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: has_input_compound UPa:UPC00231 {cardinality="2"} ! D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC05345 {cardinality="2"} ! beta-D-fructose 6-phosphate relationship: has_output_compound UPa:UPC05345 ! beta-D-fructose 6-phosphate relationship: part_of UPa:UPA00115 ! pentose phosphate pathway relationship: part_of UPa:UPA00115 {cardinality="1"} ! pentose phosphate pathway [Term] id: UPa:ULS00198 name: alpha-D-mannose 1-phosphate from D-fructose 6-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00636 ! alpha-D-mannose 1-phosphate relationship: has_output_compound UPa:UPC00636 {cardinality="1"} ! alpha-D-mannose 1-phosphate relationship: part_of UPa:UPA00126 ! GDP-alpha-D-mannose biosynthesis relationship: part_of UPa:UPA00126 {cardinality="1"} ! GDP-alpha-D-mannose biosynthesis [Term] id: UPa:ULS00199 name: pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00642 {cardinality="1"} ! 4-hydroxyphenylacetate relationship: has_input_compound UPa:UPC00642 ! 4-hydroxyphenylacetate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde relationship: has_output_compound UPa:UPC00232 ! succinate semialdehyde relationship: part_of UPa:UPA00208 {cardinality="1"} ! 4-hydroxyphenylacetate degradation relationship: part_of UPa:UPA00208 ! 4-hydroxyphenylacetate degradation [Term] id: UPa:ULS00200 name: glycine from L-allo-threonine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC05519 {cardinality="1"} ! L-allo-threonine relationship: has_input_compound UPa:UPC05519 ! L-allo-threonine relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: part_of UPa:UPA00288 {cardinality="1"} ! glycine biosynthesis relationship: part_of UPa:UPA00288 ! glycine biosynthesis [Term] id: UPa:ULS00201 name: glycine from glyoxylate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: has_input_compound UPa:UPC00048 ! glyoxylate relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: part_of UPa:UPA00288 {cardinality="1"} ! glycine biosynthesis relationship: part_of UPa:UPA00288 ! glycine biosynthesis [Term] id: UPa:ULS00202 name: acetaldehyde and glycine from L-threonine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: has_input_compound UPa:UPC00188 ! L-threonine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: part_of UPa:UPA00044 {cardinality="1"} ! L-threonine degradation via aldolase pathway relationship: part_of UPa:UPA00044 ! L-threonine degradation via aldolase pathway [Term] id: UPa:ULS00203 name: betaine aldehyde from choline (monooxygenase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: part_of UPa:UPA00529 ! betaine biosynthesis via choline pathway relationship: part_of UPa:UPA00529 {cardinality="1"} ! betaine biosynthesis via choline pathway [Term] id: UPa:ULS00204 name: choline from choline sulfate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00919 {cardinality="1"} ! choline sulfate relationship: has_input_compound UPa:UPC00919 ! choline sulfate relationship: has_output_compound UPa:UPC00114 ! choline relationship: has_output_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: part_of UPa:UPA00290 {cardinality="1"} ! choline biosynthesis relationship: part_of UPa:UPA00290 ! choline biosynthesis [Term] id: UPa:ULS00205 name: sarcosine from betaine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00719 ! betaine relationship: has_input_compound UPa:UPC00719 {cardinality="1"} ! betaine relationship: has_output_compound UPa:UPC00213 ! sarcosine relationship: has_output_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: part_of UPa:UPA00291 {cardinality="1"} ! betaine degradation relationship: part_of UPa:UPA00291 ! betaine degradation [Term] id: UPa:ULS00206 name: formaldehyde and glycine from sarcosine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: has_input_compound UPa:UPC00213 ! sarcosine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_output_compound UPa:UPC00067 ! formaldehyde relationship: part_of UPa:UPA00292 {cardinality="1"} ! sarcosine degradation relationship: part_of UPa:UPA00292 ! sarcosine degradation [Term] id: UPa:ULS00207 name: D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00067 ! formaldehyde relationship: has_input_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: part_of UPa:UPA00294 ! formaldehyde assimilation via RuMP pathway relationship: part_of UPa:UPA00294 {cardinality="1"} ! formaldehyde assimilation via RuMP pathway [Term] id: UPa:ULS00208 name: ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC07836 ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_input_compound UPa:UPC07836 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC06398 {cardinality="1"} ! ADP-L-glycero-beta-D-manno-heptose relationship: has_output_compound UPa:UPC06398 ! ADP-L-glycero-beta-D-manno-heptose relationship: part_of UPa:UPA00356 ! ADP-L-glycero-beta-D-manno-heptose biosynthesis relationship: part_of UPa:UPA00356 {cardinality="1"} ! ADP-L-glycero-beta-D-manno-heptose biosynthesis [Term] id: UPa:ULS00209 name: (S)-reticuline from (S)-norcoclaurine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC06160 ! (S)-norcoclaurine relationship: has_input_compound UPa:UPC06160 {cardinality="1"} ! (S)-norcoclaurine relationship: has_output_compound UPa:UPC02105 ! (S)-reticuline relationship: has_output_compound UPa:UPC02105 {cardinality="1"} ! (S)-reticuline relationship: part_of UPa:UPA00306 ! (S)-reticuline biosynthesis relationship: part_of UPa:UPA00306 {cardinality="1"} ! (S)-reticuline biosynthesis [Term] id: UPa:ULS00210 name: palmatine from columbamine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01795 {cardinality="1"} ! columbamine relationship: has_input_compound UPa:UPC01795 ! columbamine relationship: has_output_compound UPa:UPC05315 ! palmatine relationship: has_output_compound UPa:UPC05315 {cardinality="1"} ! palmatine relationship: part_of UPa:UPA00307 {cardinality="1"} ! palmatine biosynthesis relationship: part_of UPa:UPA00307 ! palmatine biosynthesis [Term] id: UPa:ULS00211 name: berbamunine from (R)-N-methylcoclaurine and (S)-N-methylcoclaurine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC05176 ! (S)-N-methylcoclaurine relationship: has_input_compound UPa:UPC05176 {cardinality="1"} ! (S)-N-methylcoclaurine relationship: has_input_compound UPa:UPC05243 {cardinality="1"} ! (R)-N-methylcoclaurine relationship: has_input_compound UPa:UPC05243 ! (R)-N-methylcoclaurine relationship: has_output_compound UPa:UPC05177 {cardinality="1"} ! berbamunine relationship: has_output_compound UPa:UPC05177 ! berbamunine relationship: part_of UPa:UPA00308 {cardinality="1"} ! berbamunine biosynthesis relationship: part_of UPa:UPA00308 ! berbamunine biosynthesis [Term] id: UPa:ULS00212 name: 3alpha(S)-strictosidine from secologanin and tryptamine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00398 {cardinality="1"} ! tryptamine relationship: has_input_compound UPa:UPC00398 ! tryptamine relationship: has_input_compound UPa:UPC01852 ! secologanin relationship: has_input_compound UPa:UPC01852 {cardinality="1"} ! secologanin relationship: has_output_compound UPa:UPC03470 {cardinality="1"} ! 3alpha(S)-strictosidine relationship: has_output_compound UPa:UPC03470 ! 3alpha(S)-strictosidine relationship: part_of UPa:UPA00311 {cardinality="1"} ! 3alpha(S)-strictosidine biosynthesis relationship: part_of UPa:UPA00311 ! 3alpha(S)-strictosidine biosynthesis [Term] id: UPa:ULS00213 name: L-cystathionine from O-acetyl-L-homoserine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01077 {cardinality="1"} ! O-acetyl-L-homoserine relationship: has_input_compound UPa:UPC01077 ! O-acetyl-L-homoserine relationship: has_output_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: has_output_compound UPa:UPC02291 ! L-cystathionine relationship: part_of UPa:UPA00051 ! L-methionine biosynthesis via de novo pathway relationship: part_of UPa:UPA00051 {cardinality="1"} ! L-methionine biosynthesis via de novo pathway [Term] id: UPa:ULS00214 name: L-homocysteine from O-succinyl-L-homoserine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01118 {cardinality="1"} ! O-succinyl-L-homoserine relationship: has_input_compound UPa:UPC01118 ! O-succinyl-L-homoserine relationship: has_output_compound UPa:UPC00155 ! L-homocysteine relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: part_of UPa:UPA00051 ! L-methionine biosynthesis via de novo pathway relationship: part_of UPa:UPA00051 {cardinality="1"} ! L-methionine biosynthesis via de novo pathway [Term] id: UPa:ULS00215 name: (S)-scoulerine from (S)-reticuline namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC02105 {cardinality="1"} ! (S)-reticuline relationship: has_input_compound UPa:UPC02105 ! (S)-reticuline relationship: has_output_compound UPa:UPC02106 {cardinality="1"} ! (S)-scoulerine relationship: has_output_compound UPa:UPC02106 ! (S)-scoulerine relationship: part_of UPa:UPA00319 {cardinality="1"} ! (S)-scoulerine biosynthesis relationship: part_of UPa:UPA00319 ! (S)-scoulerine biosynthesis [Term] id: UPa:ULS00216 name: S-adenosylmethioninamine from S-adenosyl-L-methionine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_output_compound UPa:UPC01137 {cardinality="1"} ! S-adenosylmethioninamine relationship: has_output_compound UPa:UPC01137 ! S-adenosylmethioninamine relationship: part_of UPa:UPA00331 {cardinality="1"} ! S-adenosylmethioninamine biosynthesis relationship: part_of UPa:UPA00331 ! S-adenosylmethioninamine biosynthesis [Term] id: UPa:ULS00217 name: indole and pyruvate from L-tryptophan namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan relationship: has_input_compound UPa:UPC00078 ! L-tryptophan relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00463 {cardinality="1"} ! indole relationship: has_output_compound UPa:UPC00463 ! indole relationship: part_of UPa:UPA00332 {cardinality="1"} ! L-tryptophan degradation via pyruvate pathway relationship: part_of UPa:UPA00332 ! L-tryptophan degradation via pyruvate pathway [Term] id: UPa:ULS00218 name: L-kynurenine from L-tryptophan namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan relationship: has_input_compound UPa:UPC00078 ! L-tryptophan relationship: has_output_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine relationship: has_output_compound UPa:UPC00328 ! L-kynurenine relationship: part_of UPa:UPA00333 {cardinality="1"} ! L-tryptophan degradation via kynurenine pathway relationship: part_of UPa:UPA00333 ! L-tryptophan degradation via kynurenine pathway [Term] id: UPa:ULS00219 name: L-alanine and anthranilate from L-kynurenine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine relationship: has_input_compound UPa:UPC00328 ! L-kynurenine relationship: has_output_compound UPa:UPC00041 ! L-alanine relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00108 ! anthranilate relationship: has_output_compound UPa:UPC00108 {cardinality="1"} ! anthranilate relationship: part_of UPa:UPA00334 {cardinality="1"} ! L-kynurenine degradation relationship: part_of UPa:UPA00334 ! L-kynurenine degradation [Term] id: UPa:ULS00220 name: iminoaspartate from L-aspartate (dehydrogenase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate relationship: has_output_compound UPa:UPC05840 ! iminoaspartate relationship: part_of UPa:UPA00253 {cardinality="1"} ! NAD(+) biosynthesis relationship: part_of UPa:UPA00253 ! NAD(+) biosynthesis [Term] id: UPa:ULS00221 name: quinolinate from iminoaspartate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate relationship: has_input_compound UPa:UPC05840 ! iminoaspartate relationship: has_output_compound UPa:UPC03722 ! quinolinate relationship: has_output_compound UPa:UPC03722 {cardinality="1"} ! quinolinate relationship: part_of UPa:UPA00253 {cardinality="1"} ! NAD(+) biosynthesis relationship: part_of UPa:UPA00253 ! NAD(+) biosynthesis [Term] id: UPa:ULS00222 name: deamido-NAD(+) from nicotinate D-ribonucleotide namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide relationship: has_input_compound UPa:UPC01185 ! nicotinate D-ribonucleotide relationship: has_output_compound UPa:UPC00857 ! deamido-NAD(+) relationship: has_output_compound UPa:UPC00857 {cardinality="1"} ! deamido-NAD(+) relationship: part_of UPa:UPA00253 {cardinality="1"} ! NAD(+) biosynthesis relationship: part_of UPa:UPA00253 ! NAD(+) biosynthesis [Term] id: UPa:ULS00223 name: nicotinate D-ribonucleotide from nicotinate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00253 {cardinality="1"} ! nicotinate relationship: has_input_compound UPa:UPC00253 ! nicotinate relationship: has_output_compound UPa:UPC01185 ! nicotinate D-ribonucleotide relationship: has_output_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide relationship: part_of UPa:UPA00253 {cardinality="1"} ! NAD(+) biosynthesis relationship: part_of UPa:UPA00253 ! NAD(+) biosynthesis [Term] id: UPa:ULS00224 name: acetyl-CoA from acetate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_input_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: part_of UPa:UPA00340 ! acetyl-CoA biosynthesis relationship: part_of UPa:UPA00340 {cardinality="1"} ! acetyl-CoA biosynthesis [Term] id: UPa:ULS00227 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00666 ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate relationship: part_of UPa:UPA00034 {cardinality="1"} ! L-lysine biosynthesis via DAP pathway relationship: part_of UPa:UPA00034 ! L-lysine biosynthesis via DAP pathway [Term] id: UPa:ULS00228 name: D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00672 {cardinality="1"} ! 2-deoxy-alpha-D-ribose 1-phosphate relationship: has_input_compound UPa:UPC00672 ! 2-deoxy-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UPA00002 {cardinality="1"} ! 2-deoxy-D-ribose 1-phosphate degradation relationship: part_of UPa:UPA00002 ! 2-deoxy-D-ribose 1-phosphate degradation [Term] id: UPa:ULS00229 name: lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00043 {cardinality="1"} ! UDP-N-acetyl-alpha-D-glucosamine relationship: has_input_compound UPa:UPC00043 ! UDP-N-acetyl-alpha-D-glucosamine relationship: has_input_compound UPa:UPC04688 ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC04688 {cardinality="2"} ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] relationship: has_output_compound UPa:UPC04919 ! lipid IV(A) relationship: has_output_compound UPa:UPC04919 {cardinality="1"} ! lipid IV(A) relationship: part_of UPa:UPA00359 ! lipid IV(A) biosynthesis relationship: part_of UPa:UPA00359 {cardinality="1"} ! lipid IV(A) biosynthesis [Term] id: UPa:ULS00230 name: KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04121 ! CMP-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC04121 {cardinality="2"} ! CMP-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC04919 {cardinality="1"} ! lipid IV(A) relationship: has_input_compound UPa:UPC04919 ! lipid IV(A) relationship: has_output_compound UPa:UPC06026 {cardinality="1"} ! KDO(2)-lipid A relationship: has_output_compound UPa:UPC06026 ! KDO(2)-lipid A relationship: part_of UPa:UPA00360 {cardinality="1"} ! KDO(2)-lipid A biosynthesis relationship: part_of UPa:UPA00360 ! KDO(2)-lipid A biosynthesis [Term] id: UPa:ULS00231 name: 6-hydroxypseudooxynicotine from nicotine (R-isomer route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC16150 ! nicotine relationship: has_input_compound UPa:UPC16150 {cardinality="1"} ! nicotine relationship: has_output_compound UPa:UPC01297 ! 6-hydroxypseudooxynicotine relationship: has_output_compound UPa:UPC01297 {cardinality="1"} ! 6-hydroxypseudooxynicotine relationship: part_of UPa:UPA00106 {cardinality="1"} ! nicotine degradation relationship: part_of UPa:UPA00106 ! nicotine degradation [Term] id: UPa:ULS00232 name: UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate relationship: has_input_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC16154 ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: has_output_compound UPa:UPC16154 {cardinality="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: part_of UPa:UPA00032 ! UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis relationship: part_of UPa:UPA00032 {cardinality="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis [Term] id: UPa:ULS00233 name: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC16154 ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: has_input_compound UPa:UPC16154 {cardinality="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: has_output_compound UPa:UPC16157 ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate relationship: has_output_compound UPa:UPC16157 {cardinality="1"} ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate relationship: part_of UPa:UPA00036 ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis relationship: part_of UPa:UPA00036 {cardinality="1"} ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis [Term] id: UPa:ULS00234 name: UDP-alpha-D-glucuronate from UDP-alpha-D-glucose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00029 ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC00029 {cardinality="1"} ! UDP-alpha-D-glucose relationship: has_output_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate relationship: part_of UPa:UPA00038 ! UDP-alpha-D-glucuronate biosynthesis relationship: part_of UPa:UPA00038 {cardinality="1"} ! UDP-alpha-D-glucuronate biosynthesis [Term] id: UPa:ULS00235 name: D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC05382 ! sedoheptulose 7-phosphate relationship: has_input_compound UPa:UPC05382 {cardinality="2"} ! sedoheptulose 7-phosphate relationship: has_output_compound UPa:UPC07836 ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC07836 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC19878 ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC19878 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: part_of UPa:UPA00041 ! D-glycero-D-manno-heptose 7-phosphate biosynthesis relationship: part_of UPa:UPA00041 {cardinality="1"} ! D-glycero-D-manno-heptose 7-phosphate biosynthesis [Term] id: UPa:ULS00236 name: D-alanine from L-alanine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00133 {cardinality="1"} ! D-alanine relationship: has_output_compound UPa:UPC00133 ! D-alanine relationship: part_of UPa:UPA00042 ! D-alanine biosynthesis relationship: part_of UPa:UPA00042 {cardinality="1"} ! D-alanine biosynthesis [Term] id: UPa:ULS00237 name: NH(3) and pyruvate from D-alanine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00133 {cardinality="1"} ! D-alanine relationship: has_input_compound UPa:UPC00133 ! D-alanine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: part_of UPa:UPA00043 ! D-alanine degradation relationship: part_of UPa:UPA00043 {cardinality="1"} ! D-alanine degradation [Term] id: UPa:ULS00238 name: cyanurate from atrazine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC06551 ! atrazine relationship: has_input_compound UPa:UPC06551 {cardinality="1"} ! atrazine relationship: has_output_compound UPa:UPC06554 ! cyanurate relationship: has_output_compound UPa:UPC06554 {cardinality="1"} ! cyanurate relationship: part_of UPa:UPA00008 ! atrazine degradation relationship: part_of UPa:UPA00008 {cardinality="1"} ! atrazine degradation [Term] id: UPa:ULS00239 name: biuret from cyanurate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC06554 ! cyanurate relationship: has_input_compound UPa:UPC06554 {cardinality="1"} ! cyanurate relationship: has_output_compound UPa:UPC06555 ! biuret relationship: has_output_compound UPa:UPC06555 {cardinality="1"} ! biuret relationship: part_of UPa:UPA00008 ! atrazine degradation relationship: part_of UPa:UPA00008 {cardinality="1"} ! atrazine degradation [Term] id: UPa:ULS00240 name: phosphatidylglycerol from CDP-diacylglycerol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00344 ! phosphatidylglycerol relationship: has_output_compound UPa:UPC00344 {cardinality="1"} ! phosphatidylglycerol relationship: part_of UPa:UPA00084 {cardinality="1"} ! phosphatidylglycerol biosynthesis relationship: part_of UPa:UPA00084 ! phosphatidylglycerol biosynthesis [Term] id: UPa:ULS00241 name: glycine from L-threonine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00188 ! L-threonine relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: part_of UPa:UPA00046 {cardinality="1"} ! L-threonine degradation via oxydo-reductase pathway relationship: part_of UPa:UPA00046 ! L-threonine degradation via oxydo-reductase pathway [Term] id: UPa:ULS00242 name: propanoate from L-threonine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00188 ! L-threonine relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: has_output_compound UPa:UPC00163 ! propanoate relationship: has_output_compound UPa:UPC00163 {cardinality="1"} ! propanoate relationship: part_of UPa:UPA00052 {cardinality="1"} ! L-threonine degradation via propanoate pathway relationship: part_of UPa:UPA00052 ! L-threonine degradation via propanoate pathway [Term] id: UPa:ULS00243 name: CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00063 ! CTP relationship: has_input_compound UPa:UPC00103 ! alpha-D-glucose 1-phosphate relationship: has_input_compound UPa:UPC00103 {cardinality="1"} ! alpha-D-glucose 1-phosphate relationship: has_output_compound UPa:UPC03599 ! CDP-3,6-dideoxy-D-mannose relationship: has_output_compound UPa:UPC03599 {cardinality="1"} ! CDP-3,6-dideoxy-D-mannose relationship: part_of UPa:UPA00055 {cardinality="1"} ! CDP-3,6-dideoxy-D-mannose biosynthesis relationship: part_of UPa:UPA00055 ! CDP-3,6-dideoxy-D-mannose biosynthesis [Term] id: UPa:ULS00244 name: alpha-ribazole from 5,6-dimethylbenzimidazole namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03114 {cardinality="1"} ! 5,6-dimethylbenzimidazole relationship: has_input_compound UPa:UPC03114 ! 5,6-dimethylbenzimidazole relationship: has_output_compound UPa:UPC05775 ! alpha-ribazole relationship: has_output_compound UPa:UPC05775 {cardinality="1"} ! alpha-ribazole relationship: part_of UPa:UPA00061 {cardinality="1"} ! alpha-ribazole biosynthesis relationship: part_of UPa:UPA00061 ! alpha-ribazole biosynthesis [Term] id: UPa:ULS00245 name: D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00880 {cardinality="1"} ! D-galactonate relationship: has_input_compound UPa:UPC00880 ! D-galactonate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UPA00081 {cardinality="1"} ! D-galactonate degradation relationship: part_of UPa:UPA00081 ! D-galactonate degradation [Term] id: UPa:ULS00246 name: vindoline from tabersonine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC09244 {cardinality="1"} ! tabersonine relationship: has_input_compound UPa:UPC09244 ! tabersonine relationship: has_output_compound UPa:UPC01626 ! vindoline relationship: has_output_compound UPa:UPC01626 {cardinality="1"} ! vindoline relationship: part_of UPa:UPA00365 ! vindoline biosynthesis relationship: part_of UPa:UPA00365 {cardinality="1"} ! vindoline biosynthesis [Term] id: UPa:ULS00247 name: alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: part_of UPa:UPA00113 ! UDP-N-acetyl-alpha-D-glucosamine biosynthesis relationship: part_of UPa:UPA00113 {cardinality="1"} ! UDP-N-acetyl-alpha-D-glucosamine biosynthesis [Term] id: UPa:ULS00248 name: N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: has_input_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC04501 ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC04501 {cardinality="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: part_of UPa:UPA00113 ! UDP-N-acetyl-alpha-D-glucosamine biosynthesis relationship: part_of UPa:UPA00113 {cardinality="1"} ! UDP-N-acetyl-alpha-D-glucosamine biosynthesis [Term] id: UPa:ULS00249 name: N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate relationship: has_input_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC04501 ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC04501 {cardinality="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: part_of UPa:UPA00113 ! UDP-N-acetyl-alpha-D-glucosamine biosynthesis relationship: part_of UPa:UPA00113 {cardinality="1"} ! UDP-N-acetyl-alpha-D-glucosamine biosynthesis [Term] id: UPa:ULS00250 name: UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04501 {cardinality="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_input_compound UPa:UPC04501 ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC00043 ! UDP-N-acetyl-alpha-D-glucosamine relationship: has_output_compound UPa:UPC00043 {cardinality="1"} ! UDP-N-acetyl-alpha-D-glucosamine relationship: part_of UPa:UPA00113 {cardinality="1"} ! UDP-N-acetyl-alpha-D-glucosamine biosynthesis relationship: part_of UPa:UPA00113 ! UDP-N-acetyl-alpha-D-glucosamine biosynthesis [Term] id: UPa:ULS00251 name: D-glucose from alpha,alpha-trehalose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01083 ! alpha,alpha-trehalose relationship: has_input_compound UPa:UPC01083 {cardinality="1"} ! alpha,alpha-trehalose relationship: has_output_compound UPa:UPC00031 ! D-glucose relationship: has_output_compound UPa:UPC00031 {cardinality="2"} ! D-glucose relationship: part_of UPa:UPA00300 ! trehalose degradation relationship: part_of UPa:UPA00300 {cardinality="1"} ! trehalose degradation [Term] id: UPa:ULS00252 name: hypotaurine from 2-aminoethanethiol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01678 ! 2-aminoethanethiol relationship: has_input_compound UPa:UPC01678 {cardinality="1"} ! 2-aminoethanethiol relationship: has_output_compound UPa:UPC00519 ! hypotaurine relationship: has_output_compound UPa:UPC00519 {cardinality="1"} ! hypotaurine relationship: part_of UPa:UPA00012 ! taurine biosynthesis relationship: part_of UPa:UPA00012 {cardinality="1"} ! taurine biosynthesis [Term] id: UPa:ULS00253 name: hypotaurine from L-cysteine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_output_compound UPa:UPC00519 ! hypotaurine relationship: has_output_compound UPa:UPC00519 {cardinality="1"} ! hypotaurine relationship: part_of UPa:UPA00012 ! taurine biosynthesis relationship: part_of UPa:UPA00012 {cardinality="1"} ! taurine biosynthesis [Term] id: UPa:ULS00254 name: taurine from hypotaurine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00519 {cardinality="1"} ! hypotaurine relationship: has_input_compound UPa:UPC00519 ! hypotaurine relationship: has_output_compound UPa:UPC00245 ! taurine relationship: has_output_compound UPa:UPC00245 {cardinality="1"} ! taurine relationship: part_of UPa:UPA00012 ! taurine biosynthesis relationship: part_of UPa:UPA00012 {cardinality="1"} ! taurine biosynthesis [Term] id: UPa:ULS00255 name: taurine from L-cysteine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00097 ! L-cysteine relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_output_compound UPa:UPC00245 ! taurine relationship: has_output_compound UPa:UPC00245 {cardinality="1"} ! taurine relationship: part_of UPa:UPA00012 ! taurine biosynthesis relationship: part_of UPa:UPA00012 {cardinality="1"} ! taurine biosynthesis [Term] id: UPa:ULS00256 name: aminoacetaldehyde and sulfite from taurine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00245 ! taurine relationship: has_input_compound UPa:UPC00245 {cardinality="1"} ! taurine relationship: has_output_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_output_compound UPa:UPC06735 {cardinality="1"} ! aminoacetaldehyde relationship: has_output_compound UPa:UPC06735 ! aminoacetaldehyde relationship: part_of UPa:UPA00336 {cardinality="1"} ! taurine degradation via aerobic pathway relationship: part_of UPa:UPA00336 ! taurine degradation via aerobic pathway [Term] id: UPa:ULS00257 name: acetyl phosphate and sulfite from taurine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00245 ! taurine relationship: has_input_compound UPa:UPC00245 {cardinality="1"} ! taurine relationship: has_output_compound UPa:UPC00094 ! sulfite relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_output_compound UPa:UPC00227 ! acetyl phosphate relationship: has_output_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate relationship: part_of UPa:UPA00336 {cardinality="1"} ! taurine degradation via aerobic pathway relationship: part_of UPa:UPA00336 ! taurine degradation via aerobic pathway [Term] id: UPa:ULS00258 name: sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00029 ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC00029 {cardinality="1"} ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00089 ! sucrose relationship: has_output_compound UPa:UPC00089 {cardinality="1"} ! sucrose relationship: part_of UPa:UPA00371 {cardinality="1"} ! sucrose biosynthesis relationship: part_of UPa:UPA00371 ! sucrose biosynthesis [Term] id: UPa:ULS00259 name: 3,4',5-trihydroxystilbene from trans-4-coumarate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00811 {cardinality="1"} ! trans-4-coumarate relationship: has_input_compound UPa:UPC00811 ! trans-4-coumarate relationship: has_output_compound UPa:UPC03582 {cardinality="1"} ! 3,4',5-trihydroxystilbene relationship: has_output_compound UPa:UPC03582 ! 3,4',5-trihydroxystilbene relationship: part_of UPa:UPA00372 {cardinality="1"} ! 3,4',5-trihydroxystilbene biosynthesis relationship: part_of UPa:UPA00372 ! 3,4',5-trihydroxystilbene biosynthesis [Term] id: UPa:ULS00260 name: N-formimidoyl-L-glutamate from L-histidine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00135 ! L-histidine relationship: has_input_compound UPa:UPC00135 {cardinality="1"} ! L-histidine relationship: has_output_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate relationship: part_of UPa:UPA00379 ! L-histidine degradation into L-glutamate relationship: part_of UPa:UPA00379 {cardinality="1"} ! L-histidine degradation into L-glutamate [Term] id: UPa:ULS00261 name: L-glutamate from N-formimidoyl-L-glutamate (hydrolase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate relationship: has_input_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: part_of UPa:UPA00379 ! L-histidine degradation into L-glutamate relationship: part_of UPa:UPA00379 {cardinality="1"} ! L-histidine degradation into L-glutamate [Term] id: UPa:ULS00262 name: L-glutamate from N-formimidoyl-L-glutamate (deiminase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate relationship: has_input_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: part_of UPa:UPA00379 ! L-histidine degradation into L-glutamate relationship: part_of UPa:UPA00379 {cardinality="1"} ! L-histidine degradation into L-glutamate [Term] id: UPa:ULS00263 name: L-glutamate from N-formimidoyl-L-glutamate (transferase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate relationship: has_input_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: part_of UPa:UPA00379 ! L-histidine degradation into L-glutamate relationship: part_of UPa:UPA00379 {cardinality="1"} ! L-histidine degradation into L-glutamate [Term] id: UPa:ULS00264 name: staphyloxanthin from farnesyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00448 {cardinality="2"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC16148 {cardinality="1"} ! staphyloxanthin relationship: has_output_compound UPa:UPC16148 ! staphyloxanthin relationship: part_of UPa:UPA00029 {cardinality="1"} ! staphyloxanthin biosynthesis relationship: part_of UPa:UPA00029 ! staphyloxanthin biosynthesis [Term] id: UPa:ULS00265 name: ethylene from S-adenosyl-L-methionine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine relationship: has_output_compound UPa:UPC06547 {cardinality="1"} ! ethylene relationship: has_output_compound UPa:UPC06547 ! ethylene relationship: part_of UPa:UPA00384 ! ethylene biosynthesis via S-adenosyl-L-methionine relationship: part_of UPa:UPA00384 {cardinality="1"} ! ethylene biosynthesis via S-adenosyl-L-methionine [Term] id: UPa:ULS00266 name: geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00353 ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate relationship: part_of UPa:UPA00389 ! geranylgeranyl diphosphate biosynthesis relationship: part_of UPa:UPA00389 {cardinality="1"} ! geranylgeranyl diphosphate biosynthesis [Term] id: UPa:ULS00267 name: 2-dehydro-3-deoxy-L-arabinonate from L-arabinose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose relationship: has_input_compound UPa:UPC00259 ! L-arabinose relationship: has_output_compound UPa:UPC00684 {cardinality="1"} ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_output_compound UPa:UPC00684 ! 2-dehydro-3-deoxy-L-arabinonate relationship: part_of UPa:UPA00141 ! L-arabinose degradation via L-arabinono-1,4-lactone pathway relationship: part_of UPa:UPA00141 {cardinality="1"} ! L-arabinose degradation via L-arabinono-1,4-lactone pathway [Term] id: UPa:ULS00268 name: glycolaldehyde and pyruvate from 2-dehydro-3-deoxy-L-arabinonate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00684 {cardinality="1"} ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_input_compound UPa:UPC00684 ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00266 ! glycolaldehyde relationship: has_output_compound UPa:UPC00266 {cardinality="1"} ! glycolaldehyde relationship: part_of UPa:UPA00141 ! L-arabinose degradation via L-arabinono-1,4-lactone pathway relationship: part_of UPa:UPA00141 {cardinality="1"} ! L-arabinose degradation via L-arabinono-1,4-lactone pathway [Term] id: UPa:ULS00269 name: 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00684 {cardinality="1"} ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_input_compound UPa:UPC00684 ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: part_of UPa:UPA00141 ! L-arabinose degradation via L-arabinono-1,4-lactone pathway relationship: part_of UPa:UPA00141 {cardinality="1"} ! L-arabinose degradation via L-arabinono-1,4-lactone pathway [Term] id: UPa:ULS00270 name: D-xylulose 5-phosphate from L-arabinose (fungal route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose relationship: has_input_compound UPa:UPC00259 ! L-arabinose relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate relationship: part_of UPa:UPA00146 ! L-arabinose degradation via L-arabinitol relationship: part_of UPa:UPA00146 {cardinality="1"} ! L-arabinose degradation via L-arabinitol [Term] id: UPa:ULS00271 name: creatine from L-arginine and glycine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC00062 ! L-arginine relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_output_compound UPa:UPC00300 ! creatine relationship: has_output_compound UPa:UPC00300 {cardinality="1"} ! creatine relationship: part_of UPa:UPA00104 ! creatine biosynthesis relationship: part_of UPa:UPA00104 {cardinality="1"} ! creatine biosynthesis [Term] id: UPa:ULS00272 name: pentalenene from farnesyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC01841 ! pentalenene relationship: has_output_compound UPa:UPC01841 {cardinality="1"} ! pentalenene relationship: part_of UPa:UPA00171 {cardinality="1"} ! pentalenene biosynthesis relationship: part_of UPa:UPA00171 ! pentalenene biosynthesis [Term] id: UPa:ULS00273 name: aristolochene from farnesyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC02004 ! aristolochene relationship: has_output_compound UPa:UPC02004 {cardinality="1"} ! aristolochene relationship: part_of UPa:UPA00177 {cardinality="1"} ! aristolochene biosynthesis relationship: part_of UPa:UPA00177 ! aristolochene biosynthesis [Term] id: UPa:ULS00274 name: germacradienol from farnesyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC16143 {cardinality="1"} ! germacradienol relationship: has_output_compound UPa:UPC16143 ! germacradienol relationship: part_of UPa:UPA00283 ! germacradienol biosynthesis relationship: part_of UPa:UPA00283 {cardinality="1"} ! germacradienol biosynthesis [Term] id: UPa:ULS00275 name: germacrene D from farnesyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC16142 {cardinality="1"} ! germacrene D relationship: has_output_compound UPa:UPC16142 ! germacrene D relationship: part_of UPa:UPA00285 ! germacrene D biosynthesis relationship: part_of UPa:UPA00285 {cardinality="1"} ! germacrene D biosynthesis [Term] id: UPa:ULS00276 name: NH(3) and pyruvate from L-alanine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: part_of UPa:UPA00527 ! L-alanine degradation via dehydrogenase pathway relationship: part_of UPa:UPA00527 {cardinality="1"} ! L-alanine degradation via dehydrogenase pathway [Term] id: UPa:ULS00277 name: pyruvate from L-alanine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00041 ! L-alanine relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: part_of UPa:UPA00528 ! L-alanine degradation via transaminase pathway relationship: part_of UPa:UPA00528 {cardinality="1"} ! L-alanine degradation via transaminase pathway [Term] id: UPa:ULS00278 name: betaine aldehyde from choline (dehydrogenase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde relationship: part_of UPa:UPA00529 ! betaine biosynthesis via choline pathway relationship: part_of UPa:UPA00529 {cardinality="1"} ! betaine biosynthesis via choline pathway [Term] id: UPa:ULS00279 name: 4-pyridoxate from pyridoxal namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00250 ! pyridoxal relationship: has_input_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: has_output_compound UPa:UPC00847 ! 4-pyridoxate relationship: has_output_compound UPa:UPC00847 {cardinality="1"} ! 4-pyridoxate relationship: part_of UPa:UPA00192 {cardinality="1"} ! B6 vitamer degradation relationship: part_of UPa:UPA00192 ! B6 vitamer degradation [Term] id: UPa:ULS00280 name: pyridoxal from pyridoxine (oxidase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine relationship: has_input_compound UPa:UPC00314 ! pyridoxine relationship: has_output_compound UPa:UPC00250 ! pyridoxal relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: part_of UPa:UPA00192 ! B6 vitamer degradation relationship: part_of UPa:UPA00192 {cardinality="1"} ! B6 vitamer degradation [Term] id: UPa:ULS00281 name: protein N(6)-(lipoyl)lysine from lipoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00725 {cardinality="1"} ! lipoate relationship: has_input_compound UPa:UPC00725 ! lipoate relationship: has_output_compound UPa:UPC16237 ! protein N(6)-(lipoyl)lysine relationship: has_output_compound UPa:UPC16237 {cardinality="1"} ! protein N(6)-(lipoyl)lysine relationship: part_of UPa:UPA00537 {cardinality="1"} ! protein lipoylation via exogenous pathway relationship: part_of UPa:UPA00537 ! protein lipoylation via exogenous pathway [Term] id: UPa:ULS00282 name: protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein] namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC05752 ! octanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC05752 {cardinality="1"} ! octanoyl-[acyl-carrier-protein] relationship: has_output_compound UPa:UPC16237 ! protein N(6)-(lipoyl)lysine relationship: has_output_compound UPa:UPC16237 {cardinality="1"} ! protein N(6)-(lipoyl)lysine relationship: part_of UPa:UPA00538 {cardinality="1"} ! protein lipoylation via endogenous pathway relationship: part_of UPa:UPA00538 ! protein lipoylation via endogenous pathway [Term] id: UPa:ULS00283 name: thiamine diphosphate from thiamine phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01081 {cardinality="1"} ! thiamine phosphate relationship: has_input_compound UPa:UPC01081 ! thiamine phosphate relationship: has_output_compound UPa:UPC00068 ! thiamine diphosphate relationship: has_output_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate relationship: part_of UPa:UPA00060 {cardinality="1"} ! thiamine diphosphate biosynthesis relationship: part_of UPa:UPA00060 ! thiamine diphosphate biosynthesis [Term] id: UPa:ULS00284 name: thiamine phosphate from thiamine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00378 {cardinality="1"} ! thiamine relationship: has_input_compound UPa:UPC00378 ! thiamine relationship: has_output_compound UPa:UPC01081 ! thiamine phosphate relationship: has_output_compound UPa:UPC01081 {cardinality="1"} ! thiamine phosphate relationship: part_of UPa:UPA00060 {cardinality="1"} ! thiamine diphosphate biosynthesis relationship: part_of UPa:UPA00060 ! thiamine diphosphate biosynthesis [Term] id: UPa:ULS00285 name: thiamine diphosphate from thiamine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00378 {cardinality="1"} ! thiamine relationship: has_input_compound UPa:UPC00378 ! thiamine relationship: has_output_compound UPa:UPC00068 ! thiamine diphosphate relationship: has_output_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate relationship: part_of UPa:UPA00060 {cardinality="1"} ! thiamine diphosphate biosynthesis relationship: part_of UPa:UPA00060 ! thiamine diphosphate biosynthesis [Term] id: UPa:ULS00286 name: CO(2) and formate from oxalate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00209 {cardinality="1"} ! oxalate relationship: has_input_compound UPa:UPC00209 ! oxalate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: part_of UPa:UPA00540 {cardinality="1"} ! oxalate degradation relationship: part_of UPa:UPA00540 ! oxalate degradation [Term] id: UPa:ULS00287 name: NAD(+) from nicotinamide D-ribonucleotide namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00455 {cardinality="1"} ! nicotinamide D-ribonucleotide relationship: has_input_compound UPa:UPC00455 ! nicotinamide D-ribonucleotide relationship: has_output_compound UPa:UPC00003 ! NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: part_of UPa:UPA00253 ! NAD(+) biosynthesis relationship: part_of UPa:UPA00253 {cardinality="1"} ! NAD(+) biosynthesis [Term] id: UPa:ULS00288 name: glycerone phosphate from L-rhamnose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00507 {cardinality="1"} ! L-rhamnose relationship: has_input_compound UPa:UPC00507 ! L-rhamnose relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: part_of UPa:UPA00541 {cardinality="1"} ! L-rhamnose degradation relationship: part_of UPa:UPA00541 ! L-rhamnose degradation [Term] id: UPa:ULS00289 name: lactose 6-phosphate from lactose (PTS route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00243 {cardinality="1"} ! lactose relationship: has_input_compound UPa:UPC00243 ! lactose relationship: has_output_compound UPa:UPC05396 {cardinality="1"} ! lactose 6-phosphate relationship: has_output_compound UPa:UPC05396 ! lactose 6-phosphate relationship: part_of UPa:UPA00542 {cardinality="1"} ! lactose degradation relationship: part_of UPa:UPA00542 ! lactose degradation [Term] id: UPa:ULS00290 name: D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC05396 {cardinality="1"} ! lactose 6-phosphate relationship: has_input_compound UPa:UPC05396 ! lactose 6-phosphate relationship: has_output_compound UPa:UPC00221 ! beta-D-glucose relationship: has_output_compound UPa:UPC00221 {cardinality="1"} ! beta-D-glucose relationship: has_output_compound UPa:UPC01113 ! D-galactose 6-phosphate relationship: has_output_compound UPa:UPC01113 {cardinality="1"} ! D-galactose 6-phosphate relationship: part_of UPa:UPA00542 ! lactose degradation relationship: part_of UPa:UPA00542 {cardinality="1"} ! lactose degradation [Term] id: UPa:ULS00291 name: GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC19878 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: has_input_compound UPa:UPC19878 ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC19881 ! GDP-D-glycero-alpha-D-manno-heptose relationship: has_output_compound UPa:UPC19881 {cardinality="1"} ! GDP-D-glycero-alpha-D-manno-heptose relationship: part_of UPa:UPA00543 ! GDP-D-glycero-alpha-D-manno-heptose biosynthesis relationship: part_of UPa:UPA00543 {cardinality="1"} ! GDP-D-glycero-alpha-D-manno-heptose biosynthesis [Term] id: UPa:ULS00292 name: cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00631 {cardinality="1"} ! 2-phospho-D-glycerate relationship: has_input_compound UPa:UPC00631 ! 2-phospho-D-glycerate relationship: has_output_compound UPa:UPC06189 ! cyclic 2,3-diphosphoglycerate relationship: has_output_compound UPa:UPC06189 {cardinality="1"} ! cyclic 2,3-diphosphoglycerate relationship: part_of UPa:UPA00551 ! cyclic 2,3-diphosphoglycerate biosynthesis relationship: part_of UPa:UPA00551 {cardinality="1"} ! cyclic 2,3-diphosphoglycerate biosynthesis [Term] id: UPa:ULS00293 name: (S)-lactate from pyruvate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00186 {cardinality="1"} ! (S)-lactate relationship: has_output_compound UPa:UPC00186 ! (S)-lactate relationship: part_of UPa:UPA00554 ! pyruvate fermentation to lactate relationship: part_of UPa:UPA00554 {cardinality="1"} ! pyruvate fermentation to lactate [Term] id: UPa:ULS00294 name: CDP-diacylglycerol from sn-glycerol 3-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: part_of UPa:UPA00557 ! CDP-diacylglycerol biosynthesis relationship: part_of UPa:UPA00557 {cardinality="1"} ! CDP-diacylglycerol biosynthesis [Term] id: UPa:ULS00295 name: phosphatidylethanolamine from CDP-diacylglycerol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00350 ! phosphatidylethanolamine relationship: has_output_compound UPa:UPC00350 {cardinality="1"} ! phosphatidylethanolamine relationship: part_of UPa:UPA00558 ! phosphatidylethanolamine biosynthesis relationship: part_of UPa:UPA00558 {cardinality="1"} ! phosphatidylethanolamine biosynthesis [Term] id: UPa:ULS00296 name: acetate and pyruvate from L-glutamate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00033 ! acetate relationship: part_of UPa:UPA00561 ! L-glutamate degradation via mesaconate pathway relationship: part_of UPa:UPA00561 {cardinality="1"} ! L-glutamate degradation via mesaconate pathway [Term] id: UPa:ULS00297 name: formate from formaldehyde (glutathione route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00067 ! formaldehyde relationship: has_input_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: part_of UPa:UPA00562 ! formaldehyde degradation relationship: part_of UPa:UPA00562 {cardinality="1"} ! formaldehyde degradation [Term] id: UPa:ULS00298 name: L-lactaldehyde and glycerone phosphate from L-fucose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01019 ! L-fucose relationship: has_input_compound UPa:UPC01019 {cardinality="1"} ! L-fucose relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00424 ! L-lactaldehyde relationship: has_output_compound UPa:UPC00424 {cardinality="1"} ! L-lactaldehyde relationship: part_of UPa:UPA00563 ! L-fucose degradation relationship: part_of UPa:UPA00563 {cardinality="1"} ! L-fucose degradation [Term] id: UPa:ULS00299 name: 2,5-dioxopentanoate from D-glucarate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00818 {cardinality="1"} ! D-glucarate relationship: has_input_compound UPa:UPC00818 ! D-glucarate relationship: has_output_compound UPa:UPC00433 {cardinality="1"} ! 2,5-dioxopentanoate relationship: has_output_compound UPa:UPC00433 ! 2,5-dioxopentanoate relationship: part_of UPa:UPA00564 ! D-glucarate degradation relationship: part_of UPa:UPA00564 {cardinality="1"} ! D-glucarate degradation [Term] id: UPa:ULS00300 name: D-glycerate from galactarate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00879 {cardinality="1"} ! galactarate relationship: has_input_compound UPa:UPC00879 ! galactarate relationship: has_output_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: part_of UPa:UPA00565 ! galactarate degradation relationship: part_of UPa:UPA00565 {cardinality="1"} ! galactarate degradation [Term] id: UPa:ULS00301 name: uridine from cytidine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00475 {cardinality="1"} ! cytidine relationship: has_input_compound UPa:UPC00475 ! cytidine relationship: has_output_compound UPa:UPC00299 {cardinality="1"} ! uridine relationship: has_output_compound UPa:UPC00299 ! uridine relationship: part_of UPa:UPA00574 ! UMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00574 {cardinality="1"} ! UMP biosynthesis via salvage pathway [Term] id: UPa:ULS00302 name: uracil from uridine (phosphorylase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00299 {cardinality="1"} ! uridine relationship: has_input_compound UPa:UPC00299 ! uridine relationship: has_output_compound UPa:UPC00106 ! uracil relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: part_of UPa:UPA00574 ! UMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00574 {cardinality="1"} ! UMP biosynthesis via salvage pathway [Term] id: UPa:ULS00303 name: uracil from uridine (hydrolase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00299 {cardinality="1"} ! uridine relationship: has_input_compound UPa:UPC00299 ! uridine relationship: has_output_compound UPa:UPC00106 ! uracil relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: part_of UPa:UPA00574 ! UMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00574 {cardinality="1"} ! UMP biosynthesis via salvage pathway [Term] id: UPa:ULS00304 name: UMP from uracil namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: has_input_compound UPa:UPC00106 ! uracil relationship: has_output_compound UPa:UPC00105 ! UMP relationship: has_output_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: part_of UPa:UPA00574 ! UMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00574 {cardinality="1"} ! UMP biosynthesis via salvage pathway [Term] id: UPa:ULS00305 name: UMP from uridine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00299 ! uridine relationship: has_input_compound UPa:UPC00299 {cardinality="1"} ! uridine relationship: has_output_compound UPa:UPC00105 ! UMP relationship: has_output_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: part_of UPa:UPA00574 ! UMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00574 {cardinality="1"} ! UMP biosynthesis via salvage pathway [Term] id: UPa:ULS00306 name: dTMP from thymine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00178 {cardinality="1"} ! thymine relationship: has_input_compound UPa:UPC00178 ! thymine relationship: has_output_compound UPa:UPC00364 ! dTMP relationship: has_output_compound UPa:UPC00364 {cardinality="1"} ! dTMP relationship: part_of UPa:UPA00578 ! dTMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00578 {cardinality="1"} ! dTMP biosynthesis via salvage pathway [Term] id: UPa:ULS00307 name: CTP from cytidine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00475 {cardinality="1"} ! cytidine relationship: has_input_compound UPa:UPC00475 ! cytidine relationship: has_output_compound UPa:UPC00063 ! CTP relationship: has_output_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: part_of UPa:UPA00579 ! CTP biosynthesis via salvage pathway relationship: part_of UPa:UPA00579 {cardinality="1"} ! CTP biosynthesis via salvage pathway [Term] id: UPa:ULS00308 name: malonate and urea from uracil namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: has_input_compound UPa:UPC00106 ! uracil relationship: has_output_compound UPa:UPC00086 ! urea relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_output_compound UPa:UPC00383 {cardinality="1"} ! malonate relationship: has_output_compound UPa:UPC00383 ! malonate relationship: part_of UPa:UPA00582 ! uracil degradation via oxidative pathway relationship: part_of UPa:UPA00582 {cardinality="1"} ! uracil degradation via oxidative pathway [Term] id: UPa:ULS00309 name: AMP from adenine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00147 {cardinality="1"} ! adenine relationship: has_input_compound UPa:UPC00147 ! adenine relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: part_of UPa:UPA00588 ! AMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00588 {cardinality="1"} ! AMP biosynthesis via salvage pathway [Term] id: UPa:ULS00310 name: IMP from inosine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00294 {cardinality="1"} ! inosine relationship: has_input_compound UPa:UPC00294 ! inosine relationship: has_output_compound UPa:UPC00130 ! IMP relationship: has_output_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: part_of UPa:UPA00591 {cardinality="1"} ! IMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00591 ! IMP biosynthesis via salvage pathway [Term] id: UPa:ULS00311 name: IMP from hypoxanthine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00262 {cardinality="1"} ! hypoxanthine relationship: has_input_compound UPa:UPC00262 ! hypoxanthine relationship: has_output_compound UPa:UPC00130 ! IMP relationship: has_output_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: part_of UPa:UPA00591 {cardinality="1"} ! IMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00591 ! IMP biosynthesis via salvage pathway [Term] id: UPa:ULS00312 name: AMP from ADP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00008 {cardinality="2"} ! ADP relationship: has_input_compound UPa:UPC00008 ! ADP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: part_of UPa:UPA00588 {cardinality="1"} ! AMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00588 ! AMP biosynthesis via salvage pathway [Term] id: UPa:ULS00313 name: (S)-allantoin from urate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00366 {cardinality="1"} ! urate relationship: has_input_compound UPa:UPC00366 ! urate relationship: has_output_compound UPa:UPC02350 {cardinality="1"} ! (S)-allantoin relationship: has_output_compound UPa:UPC02350 ! (S)-allantoin relationship: part_of UPa:UPA00394 {cardinality="1"} ! urate degradation relationship: part_of UPa:UPA00394 ! urate degradation [Term] id: UPa:ULS00314 name: allantoate from (S)-allantoin namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC02350 ! (S)-allantoin relationship: has_input_compound UPa:UPC02350 {cardinality="1"} ! (S)-allantoin relationship: has_output_compound UPa:UPC00499 ! allantoate relationship: has_output_compound UPa:UPC00499 {cardinality="1"} ! allantoate relationship: part_of UPa:UPA00395 {cardinality="1"} ! (S)-allantoin degradation relationship: part_of UPa:UPA00395 ! (S)-allantoin degradation [Term] id: UPa:ULS00315 name: (S)-ureidoglycolate from allantoate (aminidohydrolase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00499 {cardinality="1"} ! allantoate relationship: has_input_compound UPa:UPC00499 ! allantoate relationship: has_output_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: part_of UPa:UPA00395 {cardinality="1"} ! (S)-allantoin degradation relationship: part_of UPa:UPA00395 ! (S)-allantoin degradation [Term] id: UPa:ULS00316 name: (S)-ureidoglycolate from allantoate (amidohydrolase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00499 {cardinality="1"} ! allantoate relationship: has_input_compound UPa:UPC00499 ! allantoate relationship: has_output_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: part_of UPa:UPA00395 {cardinality="1"} ! (S)-allantoin degradation relationship: part_of UPa:UPA00395 ! (S)-allantoin degradation [Term] id: UPa:ULS00317 name: glyoxylate from (S)-ureidoglycolate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: has_input_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: has_output_compound UPa:UPC00048 ! glyoxylate relationship: part_of UPa:UPA00395 ! (S)-allantoin degradation relationship: part_of UPa:UPA00395 {cardinality="1"} ! (S)-allantoin degradation [Term] id: UPa:ULS00318 name: oxalurate from (S)-ureidoglycolate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00603 ! (S)-ureidoglycolate relationship: has_input_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00802 ! oxalurate relationship: has_output_compound UPa:UPC00802 {cardinality="1"} ! oxalurate relationship: part_of UPa:UPA00395 ! (S)-allantoin degradation relationship: part_of UPa:UPA00395 {cardinality="1"} ! (S)-allantoin degradation [Term] id: UPa:ULS00319 name: XMP from xanthine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00385 {cardinality="1"} ! xanthine relationship: has_input_compound UPa:UPC00385 ! xanthine relationship: has_output_compound UPa:UPC00655 {cardinality="1"} ! XMP relationship: has_output_compound UPa:UPC00655 ! XMP relationship: part_of UPa:UPA00602 ! XMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00602 {cardinality="1"} ! XMP biosynthesis via salvage pathway [Term] id: UPa:ULS00320 name: AMP from adenosine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00212 {cardinality="1"} ! adenosine relationship: has_input_compound UPa:UPC00212 ! adenosine relationship: has_output_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: part_of UPa:UPA00588 ! AMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00588 {cardinality="1"} ! AMP biosynthesis via salvage pathway [Term] id: UPa:ULS00321 name: xanthine from guanine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00242 {cardinality="1"} ! guanine relationship: has_input_compound UPa:UPC00242 ! guanine relationship: has_output_compound UPa:UPC00385 ! xanthine relationship: has_output_compound UPa:UPC00385 {cardinality="1"} ! xanthine relationship: part_of UPa:UPA00603 {cardinality="1"} ! guanine degradation relationship: part_of UPa:UPA00603 ! guanine degradation [Term] id: UPa:ULS00322 name: urate from hypoxanthine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00262 {cardinality="1"} ! hypoxanthine relationship: has_input_compound UPa:UPC00262 ! hypoxanthine relationship: has_output_compound UPa:UPC00366 {cardinality="1"} ! urate relationship: has_output_compound UPa:UPC00366 ! urate relationship: part_of UPa:UPA00604 {cardinality="1"} ! hypoxanthine degradation relationship: part_of UPa:UPA00604 ! hypoxanthine degradation [Term] id: UPa:ULS00323 name: IMP from AMP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_input_compound UPa:UPC00020 ! AMP relationship: has_output_compound UPa:UPC00130 ! IMP relationship: has_output_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: part_of UPa:UPA00591 ! IMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00591 {cardinality="1"} ! IMP biosynthesis via salvage pathway [Term] id: UPa:ULS00324 name: phosphatidate from CDP-diacylglycerol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00416 ! phosphatidate relationship: has_output_compound UPa:UPC00416 {cardinality="1"} ! phosphatidate relationship: part_of UPa:UPA00609 {cardinality="1"} ! CDP-diacylglycerol degradation relationship: part_of UPa:UPA00609 ! CDP-diacylglycerol degradation [Term] id: UPa:ULS00325 name: dUMP from dCTP (dUTP route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00458 {cardinality="1"} ! dCTP relationship: has_input_compound UPa:UPC00458 ! dCTP relationship: has_output_compound UPa:UPC00365 ! dUMP relationship: has_output_compound UPa:UPC00365 {cardinality="1"} ! dUMP relationship: part_of UPa:UPA00610 {cardinality="1"} ! dUMP biosynthesis relationship: part_of UPa:UPA00610 ! dUMP biosynthesis [Term] id: UPa:ULS00326 name: dUMP from dCTP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00458 {cardinality="1"} ! dCTP relationship: has_input_compound UPa:UPC00458 ! dCTP relationship: has_output_compound UPa:UPC00365 ! dUMP relationship: has_output_compound UPa:UPC00365 {cardinality="1"} ! dUMP relationship: part_of UPa:UPA00610 {cardinality="1"} ! dUMP biosynthesis relationship: part_of UPa:UPA00610 ! dUMP biosynthesis [Term] id: UPa:ULS00327 name: glycerone phosphate from glycerol (oxidative route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00116 {cardinality="1"} ! glycerol relationship: has_input_compound UPa:UPC00116 ! glycerol relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: part_of UPa:UPA00617 {cardinality="1"} ! glycerol fermentation relationship: part_of UPa:UPA00617 ! glycerol fermentation [Term] id: UPa:ULS00328 name: propane-1,3-diol from glycerol (reductive route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00116 {cardinality="1"} ! glycerol relationship: has_input_compound UPa:UPC00116 ! glycerol relationship: has_output_compound UPa:UPC02457 {cardinality="1"} ! propane-1,3-diol relationship: has_output_compound UPa:UPC02457 ! propane-1,3-diol relationship: part_of UPa:UPA00617 {cardinality="1"} ! glycerol fermentation relationship: part_of UPa:UPA00617 ! glycerol fermentation [Term] id: UPa:ULS00329 name: sn-glycerol 3-phosphate from glycerol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00116 {cardinality="1"} ! glycerol relationship: has_input_compound UPa:UPC00116 ! glycerol relationship: has_output_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate relationship: part_of UPa:UPA00618 {cardinality="1"} ! glycerol degradation via glycerol kinase pathway relationship: part_of UPa:UPA00618 ! glycerol degradation via glycerol kinase pathway [Term] id: UPa:ULS00330 name: glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: part_of UPa:UPA00618 ! glycerol degradation via glycerol kinase pathway relationship: part_of UPa:UPA00618 {cardinality="1"} ! glycerol degradation via glycerol kinase pathway [Term] id: UPa:ULS00331 name: glycerone phosphate from sn-glycerol 3-phosphate (aerobic route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: part_of UPa:UPA00618 ! glycerol degradation via glycerol kinase pathway relationship: part_of UPa:UPA00618 {cardinality="1"} ! glycerol degradation via glycerol kinase pathway [Term] id: UPa:ULS00332 name: (R)-lactate from methylglyoxal namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00546 {cardinality="1"} ! methylglyoxal relationship: has_input_compound UPa:UPC00546 ! methylglyoxal relationship: has_output_compound UPa:UPC00256 {cardinality="1"} ! (R)-lactate relationship: has_output_compound UPa:UPC00256 ! (R)-lactate relationship: part_of UPa:UPA00619 ! methylglyoxal degradation relationship: part_of UPa:UPA00619 {cardinality="1"} ! methylglyoxal degradation [Term] id: UPa:ULS00333 name: (R,R)-butane-2,3-diol from pyruvate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00022 {cardinality="2"} ! pyruvate relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC03044 ! (R,R)-butane-2,3-diol relationship: has_output_compound UPa:UPC03044 {cardinality="1"} ! (R,R)-butane-2,3-diol relationship: part_of UPa:UPA00626 ! (R,R)-butane-2,3-diol biosynthesis relationship: part_of UPa:UPA00626 {cardinality="1"} ! (R,R)-butane-2,3-diol biosynthesis [Term] id: UPa:ULS00334 name: D-fructose 6-phosphate from N-acetylneuraminate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00270 {cardinality="1"} ! N-acetylneuraminate relationship: has_input_compound UPa:UPC00270 ! N-acetylneuraminate relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: part_of UPa:UPA00629 ! N-acetylneuraminate degradation relationship: part_of UPa:UPA00629 {cardinality="1"} ! N-acetylneuraminate degradation [Term] id: UPa:ULS00335 name: crotonoyl-CoA from L-glutamate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00877 ! crotonoyl-CoA relationship: has_output_compound UPa:UPC00877 {cardinality="1"} ! crotonoyl-CoA relationship: part_of UPa:UPA00533 {cardinality="1"} ! L-glutamate degradation via hydroxyglutarate pathway relationship: part_of UPa:UPA00533 ! L-glutamate degradation via hydroxyglutarate pathway [Term] id: UPa:ULS00336 name: L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="2"} ! L-glutamate relationship: part_of UPa:UPA00634 ! L-glutamate biosynthesis via GLT pathway relationship: part_of UPa:UPA00634 {cardinality="1"} ! L-glutamate biosynthesis via GLT pathway [Term] id: UPa:ULS00337 name: L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="2"} ! L-glutamate relationship: part_of UPa:UPA00634 ! L-glutamate biosynthesis via GLT pathway relationship: part_of UPa:UPA00634 {cardinality="1"} ! L-glutamate biosynthesis via GLT pathway [Term] id: UPa:ULS00338 name: L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00064 ! L-glutamine relationship: has_output_compound UPa:UPC00025 ! L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="2"} ! L-glutamate relationship: part_of UPa:UPA00634 ! L-glutamate biosynthesis via GLT pathway relationship: part_of UPa:UPA00634 {cardinality="1"} ! L-glutamate biosynthesis via GLT pathway [Term] id: UPa:ULS00339 name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UPA00640 ! methanogenesis from CO(2) relationship: part_of UPa:UPA00640 {cardinality="1"} ! methanogenesis from CO(2) [Term] id: UPa:ULS00340 name: 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UPA00640 ! methanogenesis from CO(2) relationship: part_of UPa:UPA00640 {cardinality="1"} ! methanogenesis from CO(2) [Term] id: UPa:ULS00341 name: 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (hydrogen route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UPA00640 ! methanogenesis from CO(2) relationship: part_of UPa:UPA00640 {cardinality="1"} ! methanogenesis from CO(2) [Term] id: UPa:ULS00342 name: methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_input_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC03920 ! methyl-coenzyme M relationship: has_output_compound UPa:UPC03920 {cardinality="1"} ! methyl-coenzyme M relationship: part_of UPa:UPA00640 ! methanogenesis from CO(2) relationship: part_of UPa:UPA00640 {cardinality="1"} ! methanogenesis from CO(2) [Term] id: UPa:ULS00343 name: methane from methyl-coenzyme M namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03920 ! methyl-coenzyme M relationship: has_input_compound UPa:UPC03920 {cardinality="1"} ! methyl-coenzyme M relationship: has_output_compound UPa:UPC01438 ! methane relationship: has_output_compound UPa:UPC01438 {cardinality="1"} ! methane relationship: part_of UPa:UPA00646 {cardinality="1"} ! methyl-coenzyme M reduction relationship: part_of UPa:UPA00646 ! methyl-coenzyme M reduction [Term] id: UPa:ULS00344 name: coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04832 {cardinality="1"} ! coenzyme M-coenzyme B heterodisulfide relationship: has_input_compound UPa:UPC04832 ! coenzyme M-coenzyme B heterodisulfide relationship: has_output_compound UPa:UPC03576 ! coenzyme M relationship: has_output_compound UPa:UPC03576 {cardinality="1"} ! coenzyme M relationship: has_output_compound UPa:UPC04628 {cardinality="1"} ! coenzyme B relationship: has_output_compound UPa:UPC04628 ! coenzyme B relationship: part_of UPa:UPA00647 {cardinality="1"} ! coenzyme M-coenzyme B heterodisulfide reduction relationship: part_of UPa:UPA00647 ! coenzyme M-coenzyme B heterodisulfide reduction [Term] id: UPa:ULS00345 name: formate from formaldehyde (H(4)MPT route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_input_compound UPa:UPC00067 ! formaldehyde relationship: has_output_compound UPa:UPC00058 ! formate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: part_of UPa:UPA00562 ! formaldehyde degradation relationship: part_of UPa:UPA00562 {cardinality="1"} ! formaldehyde degradation [Term] id: UPa:ULS00346 name: uracil from cytosine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00380 ! cytosine relationship: has_input_compound UPa:UPC00380 {cardinality="1"} ! cytosine relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: has_output_compound UPa:UPC00106 ! uracil relationship: part_of UPa:UPA00574 ! UMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00574 {cardinality="1"} ! UMP biosynthesis via salvage pathway [Term] id: UPa:ULS00347 name: dinitrogen from nitrate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00244 {cardinality="1"} ! nitrate relationship: has_input_compound UPa:UPC00244 ! nitrate relationship: has_output_compound UPa:UPC00697 ! dinitrogen relationship: has_output_compound UPa:UPC00697 {cardinality="1"} ! dinitrogen relationship: part_of UPa:UPA00652 {cardinality="1"} ! nitrate reduction (denitrification) relationship: part_of UPa:UPA00652 ! nitrate reduction (denitrification) [Term] id: UPa:ULS00348 name: acetyl-CoA from malonyl-CoA namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00083 {cardinality="1"} ! malonyl-CoA relationship: has_input_compound UPa:UPC00083 ! malonyl-CoA relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: part_of UPa:UPA00340 ! acetyl-CoA biosynthesis relationship: part_of UPa:UPA00340 {cardinality="1"} ! acetyl-CoA biosynthesis [Term] id: UPa:ULS00349 name: malonyl-CoA from acetyl-CoA namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00083 {cardinality="1"} ! malonyl-CoA relationship: has_output_compound UPa:UPC00083 ! malonyl-CoA relationship: part_of UPa:UPA00655 {cardinality="1"} ! malonyl-CoA biosynthesis relationship: part_of UPa:UPA00655 ! malonyl-CoA biosynthesis [Term] id: UPa:ULS00350 name: heme A from heme O namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC15672 ! heme O relationship: has_input_compound UPa:UPC15672 {cardinality="1"} ! heme O relationship: has_output_compound UPa:UPC15670 ! heme A relationship: has_output_compound UPa:UPC15670 {cardinality="1"} ! heme A relationship: part_of UPa:UPA00269 ! heme A biosynthesis relationship: part_of UPa:UPA00269 {cardinality="1"} ! heme A biosynthesis [Term] id: UPa:ULS00351 name: D-tagatose 6-phosphate from D-galactose 6-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01113 {cardinality="1"} ! D-galactose 6-phosphate relationship: has_input_compound UPa:UPC01113 ! D-galactose 6-phosphate relationship: has_output_compound UPa:UPC01097 ! D-tagatose 6-phosphate relationship: has_output_compound UPa:UPC01097 {cardinality="1"} ! D-tagatose 6-phosphate relationship: part_of UPa:UPA00702 ! D-galactose 6-phosphate degradation relationship: part_of UPa:UPA00702 {cardinality="1"} ! D-galactose 6-phosphate degradation [Term] id: UPa:ULS00352 name: isocitrate from oxaloacetate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00036 ! oxaloacetate relationship: has_input_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: has_output_compound UPa:UPC00311 ! isocitrate relationship: has_output_compound UPa:UPC00311 {cardinality="1"} ! isocitrate relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle relationship: part_of UPa:UPA00703 ! glyoxylate cycle relationship: part_of UPa:UPA00703 {cardinality="1"} ! glyoxylate cycle [Term] id: UPa:ULS00353 name: (S)-malate from isocitrate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate relationship: has_input_compound UPa:UPC00311 ! isocitrate relationship: has_output_compound UPa:UPC00149 ! (S)-malate relationship: has_output_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate relationship: part_of UPa:UPA00703 ! glyoxylate cycle relationship: part_of UPa:UPA00703 {cardinality="1"} ! glyoxylate cycle [Term] id: UPa:ULS00354 name: oxaloacetate from (S)-malate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate relationship: has_input_compound UPa:UPC00149 ! (S)-malate relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: has_output_compound UPa:UPC00036 ! oxaloacetate relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle relationship: part_of UPa:UPA00703 ! glyoxylate cycle relationship: part_of UPa:UPA00703 {cardinality="1"} ! glyoxylate cycle [Term] id: UPa:ULS00355 name: D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01097 {cardinality="1"} ! D-tagatose 6-phosphate relationship: has_input_compound UPa:UPC01097 ! D-tagatose 6-phosphate relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UPA00704 ! D-tagatose 6-phosphate degradation relationship: part_of UPa:UPA00704 {cardinality="1"} ! D-tagatose 6-phosphate degradation [Term] id: UPa:ULS00356 name: phenylacetate from L-phenylalanine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC07086 {cardinality="1"} ! phenylacetate relationship: has_output_compound UPa:UPC07086 ! phenylacetate relationship: part_of UPa:UPA00139 {cardinality="1"} ! L-phenylalanine degradation relationship: part_of UPa:UPA00139 ! L-phenylalanine degradation [Term] id: UPa:ULS00357 name: trans-cinnamate from L-phenylalanine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine relationship: has_output_compound UPa:UPC00423 ! trans-cinnamate relationship: has_output_compound UPa:UPC00423 {cardinality="1"} ! trans-cinnamate relationship: part_of UPa:UPA00713 ! trans-cinnamate biosynthesis relationship: part_of UPa:UPA00713 {cardinality="1"} ! trans-cinnamate biosynthesis [Term] id: UPa:ULS00358 name: kynurenate from L-kynurenine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine relationship: has_input_compound UPa:UPC00328 ! L-kynurenine relationship: has_output_compound UPa:UPC01717 ! kynurenate relationship: has_output_compound UPa:UPC01717 {cardinality="1"} ! kynurenate relationship: part_of UPa:UPA00334 {cardinality="1"} ! L-kynurenine degradation relationship: part_of UPa:UPA00334 ! L-kynurenine degradation [Term] id: UPa:ULS00359 name: 3,4-dihydroxybenzoate from phthalate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01606 ! phthalate relationship: has_input_compound UPa:UPC01606 {cardinality="1"} ! phthalate relationship: has_output_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate relationship: part_of UPa:UPA00726 ! phthalate degradation relationship: part_of UPa:UPA00726 {cardinality="1"} ! phthalate degradation [Term] id: UPa:ULS00360 name: 1,3-diaminopropane from L-aspartate 4-semialdehyde namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00986 ! 1,3-diaminopropane relationship: has_output_compound UPa:UPC00986 {cardinality="1"} ! 1,3-diaminopropane relationship: part_of UPa:UPA00010 {cardinality="1"} ! 1,3-diaminopropane biosynthesis relationship: part_of UPa:UPA00010 ! 1,3-diaminopropane biosynthesis [Term] id: UPa:ULS00361 name: dopamine from L-tyrosine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: has_input_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC03758 ! dopamine relationship: has_output_compound UPa:UPC03758 {cardinality="1"} ! dopamine relationship: part_of UPa:UPA00747 {cardinality="1"} ! dopamine biosynthesis relationship: part_of UPa:UPA00747 ! dopamine biosynthesis [Term] id: UPa:ULS00362 name: (R)-noradrenaline from dopamine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03758 ! dopamine relationship: has_input_compound UPa:UPC03758 {cardinality="1"} ! dopamine relationship: has_output_compound UPa:UPC00547 {cardinality="1"} ! (R)-noradrenaline relationship: has_output_compound UPa:UPC00547 ! (R)-noradrenaline relationship: part_of UPa:UPA00748 {cardinality="1"} ! (R)-noradrenaline biosynthesis relationship: part_of UPa:UPA00748 ! (R)-noradrenaline biosynthesis [Term] id: UPa:ULS00363 name: (R)-adrenaline from (R)-noradrenaline namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00547 ! (R)-noradrenaline relationship: has_input_compound UPa:UPC00547 {cardinality="1"} ! (R)-noradrenaline relationship: has_output_compound UPa:UPC00788 {cardinality="1"} ! (R)-adrenaline relationship: has_output_compound UPa:UPC00788 ! (R)-adrenaline relationship: part_of UPa:UPA00749 {cardinality="1"} ! (R)-adrenaline biosynthesis relationship: part_of UPa:UPA00749 ! (R)-adrenaline biosynthesis [Term] id: UPa:ULS00364 name: phosphocholine from choline namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_output_compound UPa:UPC00588 ! phosphocholine relationship: has_output_compound UPa:UPC00588 {cardinality="1"} ! phosphocholine relationship: part_of UPa:UPA00753 {cardinality="1"} ! phosphatidylcholine biosynthesis relationship: part_of UPa:UPA00753 ! phosphatidylcholine biosynthesis [Term] id: UPa:ULS00365 name: phosphocholine from phosphoethanolamine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00346 ! phosphoethanolamine relationship: has_input_compound UPa:UPC00346 {cardinality="1"} ! phosphoethanolamine relationship: has_output_compound UPa:UPC00588 ! phosphocholine relationship: has_output_compound UPa:UPC00588 {cardinality="1"} ! phosphocholine relationship: part_of UPa:UPA00753 ! phosphatidylcholine biosynthesis relationship: part_of UPa:UPA00753 {cardinality="1"} ! phosphatidylcholine biosynthesis [Term] id: UPa:ULS00366 name: phosphatidylcholine from phosphocholine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00588 ! phosphocholine relationship: has_input_compound UPa:UPC00588 {cardinality="1"} ! phosphocholine relationship: has_output_compound UPa:UPC00157 {cardinality="1"} ! phosphatidylcholine relationship: has_output_compound UPa:UPC00157 ! phosphatidylcholine relationship: part_of UPa:UPA00753 ! phosphatidylcholine biosynthesis relationship: part_of UPa:UPA00753 {cardinality="1"} ! phosphatidylcholine biosynthesis [Term] id: UPa:ULS00367 name: phosphatidylethanolamine from ethanolamine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00189 ! ethanolamine relationship: has_input_compound UPa:UPC00189 {cardinality="1"} ! ethanolamine relationship: has_output_compound UPa:UPC00350 ! phosphatidylethanolamine relationship: has_output_compound UPa:UPC00350 {cardinality="1"} ! phosphatidylethanolamine relationship: part_of UPa:UPA00558 ! phosphatidylethanolamine biosynthesis relationship: part_of UPa:UPA00558 {cardinality="1"} ! phosphatidylethanolamine biosynthesis [Term] id: UPa:ULS00368 name: dhurrin from L-tyrosine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: has_input_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC05143 ! dhurrin relationship: has_output_compound UPa:UPC05143 {cardinality="1"} ! dhurrin relationship: part_of UPa:UPA00757 ! dhurrin biosynthesis relationship: part_of UPa:UPA00757 {cardinality="1"} ! dhurrin biosynthesis [Term] id: UPa:ULS00369 name: AMP from 3',5'-cyclic AMP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00575 ! 3',5'-cyclic AMP relationship: has_input_compound UPa:UPC00575 {cardinality="1"} ! 3',5'-cyclic AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00020 ! AMP relationship: part_of UPa:UPA00762 ! 3',5'-cyclic AMP degradation relationship: part_of UPa:UPA00762 {cardinality="1"} ! 3',5'-cyclic AMP degradation [Term] id: UPa:ULS00370 name: GMP from 3',5'-cyclic GMP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00942 ! 3',5'-cyclic GMP relationship: has_input_compound UPa:UPC00942 {cardinality="1"} ! 3',5'-cyclic GMP relationship: has_output_compound UPa:UPC00144 ! GMP relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: part_of UPa:UPA00763 ! 3',5'-cyclic GMP degradation relationship: part_of UPa:UPA00763 {cardinality="1"} ! 3',5'-cyclic GMP degradation [Term] id: UPa:ULS00371 name: 5-valerolactone from cyclopentanol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC02020 ! cyclopentanol relationship: has_input_compound UPa:UPC02020 {cardinality="1"} ! cyclopentanol relationship: has_output_compound UPa:UPC02240 {cardinality="1"} ! 5-valerolactone relationship: has_output_compound UPa:UPC02240 ! 5-valerolactone relationship: part_of UPa:UPA00764 ! cyclopentanol degradation relationship: part_of UPa:UPA00764 {cardinality="1"} ! cyclopentanol degradation [Term] id: UPa:ULS00372 name: lanosterol from farnesyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00448 {cardinality="2"} ! farnesyl diphosphate relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate relationship: has_output_compound UPa:UPC01724 ! lanosterol relationship: has_output_compound UPa:UPC01724 {cardinality="1"} ! lanosterol relationship: part_of UPa:UPA00767 ! lanosterol biosynthesis relationship: part_of UPa:UPA00767 {cardinality="1"} ! lanosterol biosynthesis [Term] id: UPa:ULS00373 name: zymosterol from lanosterol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01724 {cardinality="1"} ! lanosterol relationship: has_input_compound UPa:UPC01724 ! lanosterol relationship: has_output_compound UPa:UPC05437 ! zymosterol relationship: has_output_compound UPa:UPC05437 {cardinality="1"} ! zymosterol relationship: part_of UPa:UPA00770 ! zymosterol biosynthesis relationship: part_of UPa:UPA00770 {cardinality="1"} ! zymosterol biosynthesis [Term] id: UPa:ULS00374 name: ergosterol from zymosterol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC05437 {cardinality="1"} ! zymosterol relationship: has_input_compound UPa:UPC05437 ! zymosterol relationship: has_output_compound UPa:UPC01694 ! ergosterol relationship: has_output_compound UPa:UPC01694 {cardinality="1"} ! ergosterol relationship: part_of UPa:UPA00768 ! ergosterol biosynthesis relationship: part_of UPa:UPA00768 {cardinality="1"} ! ergosterol biosynthesis [Term] id: UPa:ULS00375 name: dehydro-D-arabinono-1,4-lactone from D-arabinose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00216 ! D-arabinose relationship: has_input_compound UPa:UPC00216 {cardinality="1"} ! D-arabinose relationship: has_output_compound UPa:UPC06316 ! dehydro-D-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC06316 {cardinality="1"} ! dehydro-D-arabinono-1,4-lactone relationship: part_of UPa:UPA00771 ! D-erythroascorbate biosynthesis relationship: part_of UPa:UPA00771 {cardinality="1"} ! D-erythroascorbate biosynthesis [Term] id: UPa:ULS00376 name: acetate from ethanol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00469 ! ethanol relationship: has_input_compound UPa:UPC00469 {cardinality="1"} ! ethanol relationship: has_output_compound UPa:UPC00033 ! acetate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: part_of UPa:UPA00780 ! ethanol degradation relationship: part_of UPa:UPA00780 {cardinality="1"} ! ethanol degradation [Term] id: UPa:ULS00377 name: D-glucose 6-phosphate and lysine from fructoselysine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC16488 {cardinality="1"} ! fructoselysine relationship: has_input_compound UPa:UPC16488 ! fructoselysine relationship: has_output_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: part_of UPa:UPA00784 ! fructoselysine degradation relationship: part_of UPa:UPA00784 {cardinality="1"} ! fructoselysine degradation [Term] id: UPa:ULS00378 name: UDP-alpha-D-xylose from UDP-alpha-D-glucuronate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate relationship: has_input_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00190 {cardinality="1"} ! UDP-alpha-D-xylose relationship: has_output_compound UPa:UPC00190 ! UDP-alpha-D-xylose relationship: part_of UPa:UPA00796 ! UDP-alpha-D-xylose biosynthesis relationship: part_of UPa:UPA00796 {cardinality="1"} ! UDP-alpha-D-xylose biosynthesis [Term] id: UPa:ULS00379 name: UDP-L-arabinose from UDP-alpha-D-xylose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00190 {cardinality="1"} ! UDP-alpha-D-xylose relationship: has_input_compound UPa:UPC00190 ! UDP-alpha-D-xylose relationship: has_output_compound UPa:UPC00935 ! UDP-L-arabinose relationship: has_output_compound UPa:UPC00935 {cardinality="1"} ! UDP-L-arabinose relationship: part_of UPa:UPA00797 ! UDP-L-arabinose biosynthesis relationship: part_of UPa:UPA00797 {cardinality="1"} ! UDP-L-arabinose biosynthesis [Term] id: UPa:ULS00380 name: all-trans-phytoene from geranylgeranyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00353 {cardinality="2"} ! geranylgeranyl diphosphate relationship: has_input_compound UPa:UPC00353 ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC05413 ! all-trans-phytoene relationship: has_output_compound UPa:UPC05413 {cardinality="1"} ! all-trans-phytoene relationship: part_of UPa:UPA00799 {cardinality="1"} ! phytoene biosynthesis relationship: part_of UPa:UPA00799 ! phytoene biosynthesis [Term] id: UPa:ULS00381 name: capsanthin from antheraxanthin namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC08579 {cardinality="1"} ! antheraxanthin relationship: has_input_compound UPa:UPC08579 ! antheraxanthin relationship: has_output_compound UPa:UPC08584 ! capsanthin relationship: has_output_compound UPa:UPC08584 {cardinality="1"} ! capsanthin relationship: part_of UPa:UPA00806 ! capsanthin biosynthesis relationship: part_of UPa:UPA00806 {cardinality="1"} ! capsanthin biosynthesis [Term] id: UPa:ULS00382 name: capsorubin from violaxanthin namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC08614 ! violaxanthin relationship: has_input_compound UPa:UPC08614 {cardinality="1"} ! violaxanthin relationship: has_output_compound UPa:UPC08585 ! capsorubin relationship: has_output_compound UPa:UPC08585 {cardinality="1"} ! capsorubin relationship: part_of UPa:UPA00807 ! capsorubin biosynthesis relationship: part_of UPa:UPA00807 {cardinality="1"} ! capsorubin biosynthesis [Term] id: UPa:ULS00383 name: 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC07729 {cardinality="1"} ! dibenzofuran relationship: has_input_compound UPa:UPC07729 ! dibenzofuran relationship: has_output_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00805 ! salicylate relationship: has_output_compound UPa:UPC00805 {cardinality="1"} ! salicylate relationship: part_of UPa:UPA00808 ! dibenzofuran degradation relationship: part_of UPa:UPA00808 {cardinality="1"} ! dibenzofuran degradation [Term] id: UPa:ULS00384 name: 2-hydroxymuconate and catechol from dibenzo-p-dioxin namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC07732 {cardinality="1"} ! dibenzo-p-dioxin relationship: has_input_compound UPa:UPC07732 ! dibenzo-p-dioxin relationship: has_output_compound UPa:UPC00090 ! catechol relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: has_output_compound UPa:UPC02501 ! 2-hydroxymuconate relationship: has_output_compound UPa:UPC02501 {cardinality="1"} ! 2-hydroxymuconate relationship: part_of UPa:UPA00809 ! dibenzo-p-dioxin degradation relationship: part_of UPa:UPA00809 {cardinality="1"} ! dibenzo-p-dioxin degradation [Term] id: UPa:ULS00385 name: D-sorbitol 6-phosphate from D-sorbitol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00794 {cardinality="1"} ! D-sorbitol relationship: has_input_compound UPa:UPC00794 ! D-sorbitol relationship: has_output_compound UPa:UPC01096 ! D-sorbitol 6-phosphate relationship: has_output_compound UPa:UPC01096 {cardinality="1"} ! D-sorbitol 6-phosphate relationship: part_of UPa:UPA00812 ! D-sorbitol degradation relationship: part_of UPa:UPA00812 {cardinality="1"} ! D-sorbitol degradation [Term] id: UPa:ULS00386 name: D-fructose 6-phosphate from D-sorbitol 6-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01096 {cardinality="1"} ! D-sorbitol 6-phosphate relationship: has_input_compound UPa:UPC01096 ! D-sorbitol 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: part_of UPa:UPA00812 ! D-sorbitol degradation relationship: part_of UPa:UPA00812 {cardinality="1"} ! D-sorbitol degradation [Term] id: UPa:ULS00387 name: D-sorbitol from D-fructose and D-glucose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00031 {cardinality="1"} ! D-glucose relationship: has_input_compound UPa:UPC00031 ! D-glucose relationship: has_input_compound UPa:UPC00095 {cardinality="1"} ! D-fructose relationship: has_input_compound UPa:UPC00095 ! D-fructose relationship: has_output_compound UPa:UPC00794 {cardinality="1"} ! D-sorbitol relationship: has_output_compound UPa:UPC00794 ! D-sorbitol relationship: part_of UPa:UPA00815 ! D-sorbitol biosynthesis relationship: part_of UPa:UPA00815 {cardinality="1"} ! D-sorbitol biosynthesis [Term] id: UPa:ULS00388 name: D-gluconate from D-glucono-1,5-lactone namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00198 ! D-glucono-1,5-lactone relationship: has_input_compound UPa:UPC00198 {cardinality="1"} ! D-glucono-1,5-lactone relationship: has_output_compound UPa:UPC00257 ! D-gluconate relationship: has_output_compound UPa:UPC00257 {cardinality="1"} ! D-gluconate relationship: part_of UPa:UPA00814 ! D-gluconate biosynthesis relationship: part_of UPa:UPA00814 {cardinality="1"} ! D-gluconate biosynthesis [Term] id: UPa:ULS00389 name: histamine from L-histidine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00135 ! L-histidine relationship: has_input_compound UPa:UPC00135 {cardinality="1"} ! L-histidine relationship: has_output_compound UPa:UPC00388 ! histamine relationship: has_output_compound UPa:UPC00388 {cardinality="1"} ! histamine relationship: part_of UPa:UPA00822 ! histamine biosynthesis relationship: part_of UPa:UPA00822 {cardinality="1"} ! histamine biosynthesis [Term] id: UPa:ULS00390 name: myo-inositol from D-glucose 6-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol relationship: has_output_compound UPa:UPC00137 ! myo-inositol relationship: part_of UPa:UPA00823 {cardinality="1"} ! myo-inositol biosynthesis relationship: part_of UPa:UPA00823 ! myo-inositol biosynthesis [Term] id: UPa:ULS00391 name: trans-4-coumarate from trans-cinnamate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00423 {cardinality="1"} ! trans-cinnamate relationship: has_input_compound UPa:UPC00423 ! trans-cinnamate relationship: has_output_compound UPa:UPC00811 ! trans-4-coumarate relationship: has_output_compound UPa:UPC00811 {cardinality="1"} ! trans-4-coumarate relationship: part_of UPa:UPA00825 {cardinality="1"} ! trans-4-coumarate biosynthesis relationship: part_of UPa:UPA00825 ! trans-4-coumarate biosynthesis [Term] id: UPa:ULS00392 name: nicotinate from nicotinamide namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00153 {cardinality="1"} ! nicotinamide relationship: has_input_compound UPa:UPC00153 ! nicotinamide relationship: has_output_compound UPa:UPC00253 {cardinality="1"} ! nicotinate relationship: has_output_compound UPa:UPC00253 ! nicotinate relationship: part_of UPa:UPA00830 {cardinality="1"} ! nicotinate biosynthesis relationship: part_of UPa:UPA00830 ! nicotinate biosynthesis relationship: part_of UPa:UPA01009 {cardinality="1"} ! nicotinate metabolism [Term] id: UPa:ULS00393 name: heme O from protoheme namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00032 ! protoheme relationship: has_input_compound UPa:UPC00032 {cardinality="1"} ! protoheme relationship: has_output_compound UPa:UPC15672 ! heme O relationship: has_output_compound UPa:UPC15672 {cardinality="1"} ! heme O relationship: part_of UPa:UPA00834 {cardinality="1"} ! heme O biosynthesis relationship: part_of UPa:UPA00834 ! heme O biosynthesis [Term] id: UPa:ULS00394 name: 3-(2,3-dihydroxyphenyl)propanoate from 3-(3-hydroxyphenyl)propanoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC11457 {cardinality="1"} ! 3-(3-hydroxyphenyl)propanoate relationship: has_input_compound UPa:UPC11457 ! 3-(3-hydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC04044 ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC04044 {cardinality="1"} ! 3-(2,3-dihydroxyphenyl)propanoate [Term] id: UPa:ULS00395 name: 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC05629 ! 3-phenylpropanoate relationship: has_input_compound UPa:UPC05629 {cardinality="1"} ! 3-phenylpropanoate relationship: has_output_compound UPa:UPC04044 {cardinality="1"} ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC04044 ! 3-(2,3-dihydroxyphenyl)propanoate relationship: part_of UPa:UPA00714 ! 3-phenylpropanoate degradation relationship: part_of UPa:UPA00714 {cardinality="1"} ! 3-phenylpropanoate degradation [Term] id: UPa:ULS00396 name: acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04044 {cardinality="1"} ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_input_compound UPa:UPC04044 ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: part_of UPa:UPA00714 ! 3-phenylpropanoate degradation relationship: part_of UPa:UPA00714 {cardinality="1"} ! 3-phenylpropanoate degradation [Term] id: UPa:ULS00397 name: acetyl-CoA from acetaldehyde namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00084 ! acetaldehyde relationship: has_input_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA [Term] id: UPa:ULS00398 name: serotonin from L-tryptophan namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00078 ! L-tryptophan relationship: has_input_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan relationship: has_output_compound UPa:UPC00780 ! serotonin relationship: has_output_compound UPa:UPC00780 {cardinality="1"} ! serotonin relationship: part_of UPa:UPA00846 {cardinality="1"} ! serotonin biosynthesis relationship: part_of UPa:UPA00846 ! serotonin biosynthesis [Term] id: UPa:ULS00399 name: 2-hydroxy-3-oxosuccinate from L-tartrate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00898 {cardinality="1"} ! L-tartrate relationship: has_input_compound UPa:UPC00898 ! L-tartrate relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate relationship: has_output_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate relationship: part_of UPa:UPA00839 {cardinality="1"} ! tartrate degradation relationship: part_of UPa:UPA00839 ! tartrate degradation [Term] id: UPa:ULS00400 name: 2-hydroxy-3-oxosuccinate from meso-tartrate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00552 {cardinality="1"} ! meso-tartrate relationship: has_input_compound UPa:UPC00552 ! meso-tartrate relationship: has_output_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate relationship: part_of UPa:UPA00839 {cardinality="1"} ! tartrate degradation relationship: part_of UPa:UPA00839 ! tartrate degradation [Term] id: UPa:ULS00401 name: D-glycerate from 2-hydroxy-3-oxosuccinate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate relationship: has_input_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate relationship: has_output_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: part_of UPa:UPA00839 {cardinality="1"} ! tartrate degradation relationship: part_of UPa:UPA00839 ! tartrate degradation [Term] id: UPa:ULS00402 name: D-glycerate from L-tartrate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00898 {cardinality="1"} ! L-tartrate relationship: has_input_compound UPa:UPC00898 ! L-tartrate relationship: has_output_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00258 ! D-glycerate relationship: part_of UPa:UPA00839 {cardinality="1"} ! tartrate degradation relationship: part_of UPa:UPA00839 ! tartrate degradation [Term] id: UPa:ULS00403 name: 3-hydroxypyruvate from D-glycerate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00258 ! D-glycerate relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00168 ! 3-hydroxypyruvate relationship: has_output_compound UPa:UPC00168 {cardinality="1"} ! 3-hydroxypyruvate relationship: part_of UPa:UPA00839 {cardinality="1"} ! tartrate degradation relationship: part_of UPa:UPA00839 ! tartrate degradation [Term] id: UPa:ULS00404 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole from thiamine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00378 {cardinality="1"} ! thiamine relationship: has_input_compound UPa:UPC00378 ! thiamine relationship: has_output_compound UPa:UPC01279 ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC01279 {cardinality="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC04294 ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: has_output_compound UPa:UPC04294 {cardinality="1"} ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: part_of UPa:UPA00841 {cardinality="1"} ! thiamine degradation relationship: part_of UPa:UPA00841 ! thiamine degradation [Term] id: UPa:ULS00405 name: taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate relationship: has_input_compound UPa:UPC00353 ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC11895 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-ol relationship: has_output_compound UPa:UPC11895 ! taxa-4(20),11-dien-5alpha-ol relationship: part_of UPa:UPA00842 {cardinality="1"} ! taxol biosynthesis relationship: part_of UPa:UPA00842 ! taxol biosynthesis [Term] id: UPa:ULS00406 name: 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC11895 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-ol relationship: has_input_compound UPa:UPC11895 ! taxa-4(20),11-dien-5alpha-ol relationship: has_output_compound UPa:UPC11899 {cardinality="1"} ! 10-deacetyl-2-debenzoylbaccatin III relationship: has_output_compound UPa:UPC11899 ! 10-deacetyl-2-debenzoylbaccatin III relationship: part_of UPa:UPA00842 {cardinality="1"} ! taxol biosynthesis relationship: part_of UPa:UPA00842 ! taxol biosynthesis [Term] id: UPa:ULS00407 name: baccatin III from 10-deacetyl-2-debenzoylbaccatin III namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC11899 {cardinality="1"} ! 10-deacetyl-2-debenzoylbaccatin III relationship: has_input_compound UPa:UPC11899 ! 10-deacetyl-2-debenzoylbaccatin III relationship: has_output_compound UPa:UPC11900 ! baccatin III relationship: has_output_compound UPa:UPC11900 {cardinality="1"} ! baccatin III relationship: part_of UPa:UPA00842 {cardinality="1"} ! taxol biosynthesis relationship: part_of UPa:UPA00842 ! taxol biosynthesis [Term] id: UPa:ULS00408 name: taxol from baccatin III namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC11900 ! baccatin III relationship: has_input_compound UPa:UPC11900 {cardinality="1"} ! baccatin III relationship: has_output_compound UPa:UPC07394 {cardinality="1"} ! taxol relationship: has_output_compound UPa:UPC07394 ! taxol relationship: part_of UPa:UPA00842 {cardinality="1"} ! taxol biosynthesis relationship: part_of UPa:UPA00842 ! taxol biosynthesis [Term] id: UPa:ULS00409 name: melatonin from serotonin namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00780 {cardinality="1"} ! serotonin relationship: has_input_compound UPa:UPC00780 ! serotonin relationship: has_output_compound UPa:UPC01598 ! melatonin relationship: has_output_compound UPa:UPC01598 {cardinality="1"} ! melatonin relationship: part_of UPa:UPA00837 {cardinality="1"} ! melatonin biosynthesis relationship: part_of UPa:UPA00837 ! melatonin biosynthesis [Term] id: UPa:ULS00410 name: 7,8-dihydroneopterin triphosphate from GTP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_output_compound UPa:UPC04895 ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC04895 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate relationship: part_of UPa:UPA00848 ! 7,8-dihydroneopterin triphosphate biosynthesis relationship: part_of UPa:UPA00848 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate biosynthesis [Term] id: UPa:ULS00411 name: 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00415 ! 7,8-dihydrofolate relationship: has_input_compound UPa:UPC00415 {cardinality="1"} ! 7,8-dihydrofolate relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:UPA00077 {cardinality="1"} ! tetrahydrofolate biosynthesis relationship: part_of UPa:UPA00077 ! tetrahydrofolate biosynthesis [Term] id: UPa:ULS00412 name: 7,8-dihydrofolate from folate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00504 {cardinality="1"} ! folate relationship: has_input_compound UPa:UPC00504 ! folate relationship: has_output_compound UPa:UPC00415 ! 7,8-dihydrofolate relationship: has_output_compound UPa:UPC00415 {cardinality="1"} ! 7,8-dihydrofolate relationship: part_of UPa:UPA00077 {cardinality="1"} ! tetrahydrofolate biosynthesis relationship: part_of UPa:UPA00077 ! tetrahydrofolate biosynthesis [Term] id: UPa:ULS00413 name: tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04895 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate relationship: has_input_compound UPa:UPC04895 ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: part_of UPa:UPA00849 ! tetrahydrobiopterin biosynthesis relationship: part_of UPa:UPA00849 {cardinality="1"} ! tetrahydrobiopterin biosynthesis [Term] id: UPa:ULS00414 name: tetrahydrobiopterin from biopterin namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC06313 {cardinality="1"} ! biopterin relationship: has_input_compound UPa:UPC06313 ! biopterin relationship: has_output_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: part_of UPa:UPA00849 ! tetrahydrobiopterin biosynthesis relationship: part_of UPa:UPA00849 {cardinality="1"} ! tetrahydrobiopterin biosynthesis [Term] id: UPa:ULS00415 name: 2-dehydro-3-deoxy-D-gluconate from pectin namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00714 {cardinality="1"} ! pectin relationship: has_input_compound UPa:UPC00714 ! pectin relationship: has_output_compound UPa:UPC00204 ! 2-dehydro-3-deoxy-D-gluconate relationship: has_output_compound UPa:UPC00204 {cardinality="1"} ! 2-dehydro-3-deoxy-D-gluconate relationship: part_of UPa:UPA00545 {cardinality="1"} ! pectin degradation relationship: part_of UPa:UPA00545 ! pectin degradation [Term] id: UPa:ULS00416 name: D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00204 {cardinality="1"} ! 2-dehydro-3-deoxy-D-gluconate relationship: has_input_compound UPa:UPC00204 ! 2-dehydro-3-deoxy-D-gluconate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UPA00856 ! 2-dehydro-3-deoxy-D-gluconate degradation relationship: part_of UPa:UPA00856 {cardinality="1"} ! 2-dehydro-3-deoxy-D-gluconate degradation [Term] id: UPa:ULS00417 name: 3-phospho-D-glycerate from glycolate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00160 ! glycolate relationship: has_input_compound UPa:UPC00160 {cardinality="1"} ! glycolate relationship: has_output_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: part_of UPa:UPA00864 ! glycolate degradation relationship: part_of UPa:UPA00864 {cardinality="1"} ! glycolate degradation [Term] id: UPa:ULS00418 name: glycolate from 2-phosphoglycolate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00988 {cardinality="1"} ! 2-phosphoglycolate relationship: has_input_compound UPa:UPC00988 ! 2-phosphoglycolate relationship: has_output_compound UPa:UPC00160 ! glycolate relationship: has_output_compound UPa:UPC00160 {cardinality="1"} ! glycolate relationship: part_of UPa:UPA00865 ! glycolate biosynthesis relationship: part_of UPa:UPA00865 {cardinality="1"} ! glycolate biosynthesis [Term] id: UPa:ULS00419 name: glutaryl-CoA from L-lysine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_input_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC00527 {cardinality="1"} ! glutaryl-CoA relationship: has_output_compound UPa:UPC00527 ! glutaryl-CoA relationship: part_of UPa:UPA00868 ! L-lysine degradation via saccharopine pathway relationship: part_of UPa:UPA00868 {cardinality="1"} ! L-lysine degradation via saccharopine pathway [Term] id: UPa:ULS00420 name: glutarate from L-lysine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_input_compound UPa:UPC00047 ! L-lysine relationship: has_output_compound UPa:UPC00489 ! glutarate relationship: has_output_compound UPa:UPC00489 {cardinality="1"} ! glutarate relationship: part_of UPa:UPA00869 {cardinality="1"} ! L-lysine degradation via acetylation pathway relationship: part_of UPa:UPA00869 ! L-lysine degradation via acetylation pathway [Term] id: UPa:ULS00421 name: 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03506 {cardinality="1"} ! indoleglycerol phosphate relationship: has_input_compound UPa:UPC03506 ! indoleglycerol phosphate relationship: has_output_compound UPa:UPC15770 {cardinality="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one relationship: has_output_compound UPa:UPC15770 ! 2,4-dihydroxy-1,4-benzoxazin-3-one relationship: part_of UPa:UPA00872 {cardinality="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one biosynthesis relationship: part_of UPa:UPA00872 ! 2,4-dihydroxy-1,4-benzoxazin-3-one biosynthesis [Term] id: UPa:ULS00422 name: benzoate from (R)-mandelate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01983 ! (R)-mandelate relationship: has_input_compound UPa:UPC01983 {cardinality="1"} ! (R)-mandelate relationship: has_output_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: has_output_compound UPa:UPC00180 ! benzoate relationship: part_of UPa:UPA00873 {cardinality="1"} ! (R)-mandelate degradation relationship: part_of UPa:UPA00873 ! (R)-mandelate degradation [Term] id: UPa:ULS00423 name: tetrahydrobiopterin from dihydrobiopterin namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00268 {cardinality="1"} ! dihydrobiopterin relationship: has_input_compound UPa:UPC00268 ! dihydrobiopterin relationship: has_output_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00272 ! tetrahydrobiopterin relationship: part_of UPa:UPA00849 {cardinality="1"} ! tetrahydrobiopterin biosynthesis relationship: part_of UPa:UPA00849 ! tetrahydrobiopterin biosynthesis [Term] id: UPa:ULS00424 name: 4-methyl-2-oxopentanoate from L-leucine (aminotransferase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00123 {cardinality="1"} ! L-leucine relationship: has_input_compound UPa:UPC00123 ! L-leucine relationship: has_output_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate relationship: part_of UPa:UPA00363 ! L-leucine degradation relationship: part_of UPa:UPA00363 {cardinality="1"} ! L-leucine degradation [Term] id: UPa:ULS00425 name: 4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00123 {cardinality="1"} ! L-leucine relationship: has_input_compound UPa:UPC00123 ! L-leucine relationship: has_output_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate relationship: part_of UPa:UPA00363 ! L-leucine degradation relationship: part_of UPa:UPA00363 {cardinality="1"} ! L-leucine degradation [Term] id: UPa:ULS00426 name: 3-isovaleryl-CoA from 4-methyl-2-oxopentanoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate relationship: has_input_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC02939 ! 3-isovaleryl-CoA relationship: has_output_compound UPa:UPC02939 {cardinality="1"} ! 3-isovaleryl-CoA relationship: part_of UPa:UPA00363 ! L-leucine degradation relationship: part_of UPa:UPA00363 {cardinality="1"} ! L-leucine degradation [Term] id: UPa:ULS00427 name: (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC02939 {cardinality="1"} ! 3-isovaleryl-CoA relationship: has_input_compound UPa:UPC02939 ! 3-isovaleryl-CoA relationship: has_output_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: part_of UPa:UPA00363 ! L-leucine degradation relationship: part_of UPa:UPA00363 {cardinality="1"} ! L-leucine degradation [Term] id: UPa:ULS00428 name: (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC06099 {cardinality="1"} ! (4R)-limonene relationship: has_input_compound UPa:UPC06099 ! (4R)-limonene relationship: has_output_compound UPa:UPC11937 ! (1S,4R)-1-hydroxylimonen-2-one relationship: has_output_compound UPa:UPC11937 {cardinality="1"} ! (1S,4R)-1-hydroxylimonen-2-one relationship: part_of UPa:UPA00987 ! (4R)-limonene degradation relationship: part_of UPa:UPA00987 {cardinality="1"} ! (4R)-limonene degradation [Term] id: UPa:ULS00429 name: (1R,4S)-isodihydrocarvone from (4R)-limonene namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC06099 {cardinality="1"} ! (4R)-limonene relationship: has_input_compound UPa:UPC06099 ! (4R)-limonene relationship: has_output_compound UPa:UPC11412 ! (1R,4S)-isodihydrocarvone relationship: has_output_compound UPa:UPC11412 {cardinality="1"} ! (1R,4S)-isodihydrocarvone relationship: part_of UPa:UPA00987 ! (4R)-limonene degradation relationship: part_of UPa:UPA00987 {cardinality="1"} ! (4R)-limonene degradation [Term] id: UPa:ULS00430 name: formaldehyde from methylamine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00218 ! methylamine relationship: has_input_compound UPa:UPC00218 {cardinality="1"} ! methylamine relationship: has_output_compound UPa:UPC00067 ! formaldehyde relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: part_of UPa:UPA00895 ! methylamine degradation relationship: part_of UPa:UPA00895 {cardinality="1"} ! methylamine degradation [Term] id: UPa:ULS00431 name: acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_input_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00164 {cardinality="1"} ! acetoacetate relationship: has_output_compound UPa:UPC00164 ! acetoacetate relationship: part_of UPa:UPA00896 ! (S)-3-hydroxy-3-methylglutaryl-CoA degradation relationship: part_of UPa:UPA00896 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA degradation [Term] id: UPa:ULS00432 name: S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine relationship: has_input_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC04188 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC04188 {cardinality="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:UPA00904 ! L-methionine biosynthesis via salvage pathway relationship: part_of UPa:UPA00904 {cardinality="1"} ! L-methionine biosynthesis via salvage pathway [Term] id: UPa:ULS00433 name: S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine relationship: has_input_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC04188 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC04188 {cardinality="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:UPA00904 ! L-methionine biosynthesis via salvage pathway relationship: part_of UPa:UPA00904 {cardinality="1"} ! L-methionine biosynthesis via salvage pathway [Term] id: UPa:ULS00434 name: L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04188 {cardinality="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_input_compound UPa:UPC04188 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC00073 ! L-methionine relationship: part_of UPa:UPA00904 ! L-methionine biosynthesis via salvage pathway relationship: part_of UPa:UPA00904 {cardinality="1"} ! L-methionine biosynthesis via salvage pathway [Term] id: UPa:ULS00435 name: 4-aminobutanoate from putrescine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_input_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00334 ! 4-aminobutanoate relationship: has_output_compound UPa:UPC00334 {cardinality="1"} ! 4-aminobutanoate relationship: part_of UPa:UPA00188 ! putrescine degradation relationship: part_of UPa:UPA00188 {cardinality="1"} ! putrescine degradation [Term] id: UPa:ULS00436 name: ppGpp from GTP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC00044 ! GTP relationship: has_output_compound UPa:UPC01228 ! ppGpp relationship: has_output_compound UPa:UPC01228 {cardinality="1"} ! ppGpp relationship: part_of UPa:UPA00908 ! ppGpp biosynthesis relationship: part_of UPa:UPA00908 {cardinality="1"} ! ppGpp biosynthesis [Term] id: UPa:ULS00437 name: ppGpp from GDP namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_input_compound UPa:UPC00035 ! GDP relationship: has_output_compound UPa:UPC01228 {cardinality="1"} ! ppGpp relationship: has_output_compound UPa:UPC01228 ! ppGpp relationship: part_of UPa:UPA00908 {cardinality="1"} ! ppGpp biosynthesis relationship: part_of UPa:UPA00908 ! ppGpp biosynthesis [Term] id: UPa:ULS00438 name: GMP from guanine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00242 {cardinality="1"} ! guanine relationship: has_input_compound UPa:UPC00242 ! guanine relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: has_output_compound UPa:UPC00144 ! GMP relationship: part_of UPa:UPA00909 {cardinality="1"} ! GMP biosynthesis via salvage pathway relationship: part_of UPa:UPA00909 ! GMP biosynthesis via salvage pathway [Term] id: UPa:ULS00439 name: D-ribose 5-phosphate from beta-D-ribopyranose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC08353 {cardinality="1"} ! beta-D-ribopyranose relationship: has_input_compound UPa:UPC08353 ! beta-D-ribopyranose relationship: has_output_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00117 ! D-ribose 5-phosphate relationship: part_of UPa:UPA00916 {cardinality="1"} ! D-ribose degradation relationship: part_of UPa:UPA00916 ! D-ribose degradation [Term] id: UPa:ULS00440 name: nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00153 {cardinality="1"} ! nicotinamide relationship: has_input_compound UPa:UPC00153 ! nicotinamide relationship: has_output_compound UPa:UPC00455 ! nicotinamide D-ribonucleotide relationship: has_output_compound UPa:UPC00455 {cardinality="1"} ! nicotinamide D-ribonucleotide relationship: part_of UPa:UPA00253 {cardinality="1"} ! NAD(+) biosynthesis relationship: part_of UPa:UPA00253 ! NAD(+) biosynthesis [Term] id: UPa:ULS00441 name: formate from pyruvate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00058 ! formate relationship: part_of UPa:UPA00920 {cardinality="1"} ! pyruvate fermentation relationship: part_of UPa:UPA00920 ! pyruvate fermentation [Term] id: UPa:ULS00442 name: stachyose from raffinose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00492 {cardinality="1"} ! raffinose relationship: has_input_compound UPa:UPC00492 ! raffinose relationship: has_output_compound UPa:UPC01613 ! stachyose relationship: has_output_compound UPa:UPC01613 {cardinality="1"} ! stachyose relationship: part_of UPa:UPA00925 ! stachyose biosynthesis relationship: part_of UPa:UPA00925 {cardinality="1"} ! stachyose biosynthesis [Term] id: UPa:ULS00443 name: formaldehyde from methanol namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00132 {cardinality="1"} ! methanol relationship: has_input_compound UPa:UPC00132 ! methanol relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_output_compound UPa:UPC00067 ! formaldehyde relationship: part_of UPa:UPA00928 ! methanol degradation relationship: part_of UPa:UPA00928 {cardinality="1"} ! methanol degradation [Term] id: UPa:ULS00444 name: acetoacetyl-CoA from succinyl-CoA namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_output_compound UPa:UPC00332 {cardinality="1"} ! acetoacetyl-CoA relationship: has_output_compound UPa:UPC00332 ! acetoacetyl-CoA relationship: part_of UPa:UPA00929 ! succinyl-CoA degradation relationship: part_of UPa:UPA00929 {cardinality="1"} ! succinyl-CoA degradation [Term] id: UPa:ULS00445 name: L-seryl-tRNA(Sec) from L-serine and tRNA(Sec) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC16636 ! tRNA(Sec) relationship: has_input_compound UPa:UPC16636 {cardinality="1"} ! tRNA(Sec) relationship: has_output_compound UPa:UPC06481 ! L-seryl-tRNA(Sec) relationship: has_output_compound UPa:UPC06481 {cardinality="1"} ! L-seryl-tRNA(Sec) relationship: part_of UPa:UPA00906 ! selenocysteinyl-tRNA(Sec) biosynthesis relationship: part_of UPa:UPA00906 {cardinality="1"} ! selenocysteinyl-tRNA(Sec) biosynthesis [Term] id: UPa:ULS00446 name: selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC06481 {cardinality="1"} ! L-seryl-tRNA(Sec) relationship: has_input_compound UPa:UPC06481 ! L-seryl-tRNA(Sec) relationship: has_output_compound UPa:UPC06482 ! selenocysteinyl-tRNA(Sec) relationship: has_output_compound UPa:UPC06482 {cardinality="1"} ! selenocysteinyl-tRNA(Sec) relationship: part_of UPa:UPA00906 ! selenocysteinyl-tRNA(Sec) biosynthesis relationship: part_of UPa:UPA00906 {cardinality="1"} ! selenocysteinyl-tRNA(Sec) biosynthesis [Term] id: UPa:ULS00447 name: selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC06481 {cardinality="1"} ! L-seryl-tRNA(Sec) relationship: has_input_compound UPa:UPC06481 ! L-seryl-tRNA(Sec) relationship: has_output_compound UPa:UPC06482 ! selenocysteinyl-tRNA(Sec) relationship: has_output_compound UPa:UPC06482 {cardinality="1"} ! selenocysteinyl-tRNA(Sec) relationship: part_of UPa:UPA00906 ! selenocysteinyl-tRNA(Sec) biosynthesis relationship: part_of UPa:UPA00906 {cardinality="1"} ! selenocysteinyl-tRNA(Sec) biosynthesis [Term] id: UPa:ULS00448 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04916 {cardinality="1"} ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: has_input_compound UPa:UPC04916 ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UPA00074 ! IMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00074 {cardinality="1"} ! IMP biosynthesis via de novo pathway [Term] id: UPa:ULS00449 name: acetaldehyde and pyruvate from p-cumate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC06578 {cardinality="1"} ! p-cumate relationship: has_input_compound UPa:UPC06578 ! p-cumate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00084 ! acetaldehyde relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: part_of UPa:UPA00937 ! p-cumate degradation relationship: part_of UPa:UPA00937 {cardinality="1"} ! p-cumate degradation [Term] id: UPa:ULS00450 name: succinyl-CoA from propanoyl-CoA namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00100 {cardinality="1"} ! propanoyl-CoA relationship: has_input_compound UPa:UPC00100 ! propanoyl-CoA relationship: has_output_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: part_of UPa:UPA00945 ! propanoyl-CoA degradation relationship: part_of UPa:UPA00945 {cardinality="1"} ! propanoyl-CoA degradation [Term] id: UPa:ULS00451 name: glycine from 2-phosphoglycolate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00988 {cardinality="1"} ! 2-phosphoglycolate relationship: has_input_compound UPa:UPC00988 ! 2-phosphoglycolate relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: part_of UPa:UPA00951 ! photorespiration relationship: part_of UPa:UPA00951 {cardinality="1"} ! photorespiration [Term] id: UPa:ULS00452 name: 3-phospho-D-glycerate from glycine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00197 ! 3-phospho-D-glycerate relationship: part_of UPa:UPA00951 ! photorespiration relationship: part_of UPa:UPA00951 {cardinality="1"} ! photorespiration [Term] id: UPa:ULS00453 name: 6-hydroxypseudooxynicotine from nicotine (S-isomer route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC16150 ! nicotine relationship: has_input_compound UPa:UPC16150 {cardinality="1"} ! nicotine relationship: has_output_compound UPa:UPC01297 ! 6-hydroxypseudooxynicotine relationship: has_output_compound UPa:UPC01297 {cardinality="1"} ! 6-hydroxypseudooxynicotine relationship: part_of UPa:UPA00106 {cardinality="1"} ! nicotine degradation relationship: part_of UPa:UPA00106 ! nicotine degradation [Term] id: UPa:ULS00454 name: 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01297 {cardinality="1"} ! 6-hydroxypseudooxynicotine relationship: has_input_compound UPa:UPC01297 ! 6-hydroxypseudooxynicotine relationship: has_output_compound UPa:UPC03056 ! 2,6-dihydroxypyridine relationship: has_output_compound UPa:UPC03056 {cardinality="1"} ! 2,6-dihydroxypyridine relationship: has_output_compound UPa:UPC15987 ! 4-(methylamino)butanoate relationship: has_output_compound UPa:UPC15987 {cardinality="1"} ! 4-(methylamino)butanoate relationship: part_of UPa:UPA00106 {cardinality="1"} ! nicotine degradation relationship: part_of UPa:UPA00106 ! nicotine degradation [Term] id: UPa:ULS00455 name: 2-deoxystreptamine from D-glucose 6-phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC02627 {cardinality="1"} ! 2-deoxystreptamine relationship: has_output_compound UPa:UPC02627 ! 2-deoxystreptamine relationship: part_of UPa:UPA00907 ! 2-deoxystreptamine biosynthesis relationship: part_of UPa:UPA00907 {cardinality="1"} ! 2-deoxystreptamine biosynthesis [Term] id: UPa:ULS00456 name: (4S)-limonene from geranyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_output_compound UPa:UPC00521 ! (4S)-limonene relationship: has_output_compound UPa:UPC00521 {cardinality="1"} ! (4S)-limonene relationship: part_of UPa:UPA00984 {cardinality="1"} ! (4S)-limonene biosynthesis relationship: part_of UPa:UPA00984 ! (4S)-limonene biosynthesis [Term] id: UPa:ULS00457 name: (4R)-limonene from geranyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_output_compound UPa:UPC06099 ! (4R)-limonene relationship: has_output_compound UPa:UPC06099 {cardinality="1"} ! (4R)-limonene relationship: part_of UPa:UPA00983 {cardinality="1"} ! (4R)-limonene biosynthesis relationship: part_of UPa:UPA00983 ! (4R)-limonene biosynthesis [Term] id: UPa:ULS00458 name: (-)-alpha-pinene from geranyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_output_compound UPa:UPC06308 ! (-)-alpha-pinene relationship: has_output_compound UPa:UPC06308 {cardinality="1"} ! (-)-alpha-pinene relationship: part_of UPa:UPA00985 {cardinality="1"} ! (-)-alpha-pinene biosynthesis relationship: part_of UPa:UPA00985 ! (-)-alpha-pinene biosynthesis [Term] id: UPa:ULS00459 name: (-)-beta-pinene from geranyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate relationship: has_output_compound UPa:UPC06307 ! (-)-beta-pinene relationship: has_output_compound UPa:UPC06307 {cardinality="1"} ! (-)-beta-pinene relationship: part_of UPa:UPA00986 {cardinality="1"} ! (-)-beta-pinene biosynthesis relationship: part_of UPa:UPA00986 ! (-)-beta-pinene biosynthesis [Term] id: UPa:ULS00460 name: FMN from riboflavin (CTP route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00255 {cardinality="1"} ! riboflavin relationship: has_input_compound UPa:UPC00255 ! riboflavin relationship: has_output_compound UPa:UPC00061 ! FMN relationship: has_output_compound UPa:UPC00061 {cardinality="1"} ! FMN relationship: part_of UPa:UPA00276 {cardinality="1"} ! FMN biosynthesis relationship: part_of UPa:UPA00276 ! FMN biosynthesis [Term] id: UPa:ULS00462 name: GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00636 {cardinality="1"} ! alpha-D-mannose 1-phosphate relationship: has_input_compound UPa:UPC00636 ! alpha-D-mannose 1-phosphate relationship: has_output_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: part_of UPa:UPA00126 ! GDP-alpha-D-mannose biosynthesis relationship: part_of UPa:UPA00126 {cardinality="1"} ! GDP-alpha-D-mannose biosynthesis [Term] id: UPa:ULS00463 name: GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GDP route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00636 {cardinality="1"} ! alpha-D-mannose 1-phosphate relationship: has_input_compound UPa:UPC00636 ! alpha-D-mannose 1-phosphate relationship: has_output_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: part_of UPa:UPA00126 ! GDP-alpha-D-mannose biosynthesis relationship: part_of UPa:UPA00126 {cardinality="1"} ! GDP-alpha-D-mannose biosynthesis [Term] id: UPa:ULS00464 name: L-ascorbate from GDP-alpha-D-mannose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_output_compound UPa:UPC00072 ! L-ascorbate relationship: part_of UPa:UPA00990 ! L-ascorbate biosynthesis via GDP-alpha-D-mannose pathway relationship: part_of UPa:UPA00990 {cardinality="1"} ! L-ascorbate biosynthesis via GDP-alpha-D-mannose pathway [Term] id: UPa:ULS00465 name: L-ascorbate from UDP-alpha-D-glucuronate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate relationship: has_input_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_output_compound UPa:UPC00072 ! L-ascorbate relationship: part_of UPa:UPA00991 ! L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway relationship: part_of UPa:UPA00991 {cardinality="1"} ! L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway [Term] id: UPa:ULS00466 name: phosphatidylcholine from choline namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00114 ! choline relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_output_compound UPa:UPC00157 ! phosphatidylcholine relationship: has_output_compound UPa:UPC00157 {cardinality="1"} ! phosphatidylcholine relationship: part_of UPa:UPA00753 ! phosphatidylcholine biosynthesis relationship: part_of UPa:UPA00753 {cardinality="1"} ! phosphatidylcholine biosynthesis [Term] id: UPa:ULS00467 name: CO(2) and NH(3) from carbamoyl phosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00011 ! CO(2) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 ! NH(3) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: part_of UPa:UPA00996 ! carbamoyl phosphate degradation relationship: part_of UPa:UPA00996 {cardinality="1"} ! carbamoyl phosphate degradation [Term] id: UPa:ULS00468 name: putrescine from N-carbamoylputrescine (amidase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00436 {cardinality="1"} ! N-carbamoylputrescine relationship: has_input_compound UPa:UPC00436 ! N-carbamoylputrescine relationship: has_output_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: part_of UPa:UPA00534 ! putrescine biosynthesis via agmatine pathway relationship: part_of UPa:UPA00534 {cardinality="1"} ! putrescine biosynthesis via agmatine pathway [Term] id: UPa:ULS00469 name: putrescine from N-carbamoylputrescine (transferase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00436 {cardinality="1"} ! N-carbamoylputrescine relationship: has_input_compound UPa:UPC00436 ! N-carbamoylputrescine relationship: has_output_compound UPa:UPC00134 ! putrescine relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: part_of UPa:UPA00534 ! putrescine biosynthesis via agmatine pathway relationship: part_of UPa:UPA00534 {cardinality="1"} ! putrescine biosynthesis via agmatine pathway [Term] id: UPa:ULS00470 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04376 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_input_compound UPa:UPC04376 {cardinality="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:UPA00074 ! IMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00074 {cardinality="1"} ! IMP biosynthesis via de novo pathway [Term] id: UPa:ULS00471 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_input_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC04751 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_output_compound UPa:UPC04751 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: part_of UPa:UPA00074 ! IMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00074 {cardinality="1"} ! IMP biosynthesis via de novo pathway [Term] id: UPa:ULS00472 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_input_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC04751 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_output_compound UPa:UPC04751 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: part_of UPa:UPA00074 ! IMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00074 {cardinality="1"} ! IMP biosynthesis via de novo pathway [Term] id: UPa:ULS00473 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04751 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_input_compound UPa:UPC04751 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_output_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UPA00074 ! IMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00074 {cardinality="1"} ! IMP biosynthesis via de novo pathway [Term] id: UPa:ULS00474 name: 8-amino-7-oxononanoate from pimeloyl-CoA namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01063 {cardinality="1"} ! pimeloyl-CoA relationship: has_input_compound UPa:UPC01063 ! pimeloyl-CoA relationship: has_output_compound UPa:UPC01092 ! 8-amino-7-oxononanoate relationship: has_output_compound UPa:UPC01092 {cardinality="1"} ! 8-amino-7-oxononanoate relationship: part_of UPa:UPA00078 ! biotin biosynthesis relationship: part_of UPa:UPA00078 {cardinality="1"} ! biotin biosynthesis [Term] id: UPa:ULS00475 name: 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01092 {cardinality="1"} ! 8-amino-7-oxononanoate relationship: has_input_compound UPa:UPC01092 ! 8-amino-7-oxononanoate relationship: has_output_compound UPa:UPC01037 ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC01037 {cardinality="1"} ! 7,8-diaminononanoate relationship: part_of UPa:UPA00078 ! biotin biosynthesis relationship: part_of UPa:UPA00078 {cardinality="1"} ! biotin biosynthesis [Term] id: UPa:ULS00476 name: 7,8-diaminononanoate from 8-amino-7-oxononanoate (Lys route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01092 {cardinality="1"} ! 8-amino-7-oxononanoate relationship: has_input_compound UPa:UPC01092 ! 8-amino-7-oxononanoate relationship: has_output_compound UPa:UPC01037 ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC01037 {cardinality="1"} ! 7,8-diaminononanoate relationship: part_of UPa:UPA00078 ! biotin biosynthesis relationship: part_of UPa:UPA00078 {cardinality="1"} ! biotin biosynthesis [Term] id: UPa:ULS00477 name: biotin from 7,8-diaminononanoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01037 {cardinality="1"} ! 7,8-diaminononanoate relationship: has_input_compound UPa:UPC01037 ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC00120 {cardinality="1"} ! biotin relationship: has_output_compound UPa:UPC00120 ! biotin relationship: part_of UPa:UPA00078 ! biotin biosynthesis relationship: part_of UPa:UPA00078 {cardinality="1"} ! biotin biosynthesis [Term] id: UPa:ULS00478 name: (S)-dihydroorotate from bicarbonate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00288 ! bicarbonate relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_output_compound UPa:UPC00337 ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate relationship: part_of UPa:UPA00070 ! UMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00070 {cardinality="1"} ! UMP biosynthesis via de novo pathway [Term] id: UPa:ULS00479 name: orotate from (S)-dihydroorotate (O2 route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00295 ! orotate relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate relationship: part_of UPa:UPA00070 ! UMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00070 {cardinality="1"} ! UMP biosynthesis via de novo pathway [Term] id: UPa:ULS00480 name: orotate from (S)-dihydroorotate (NAD(+) route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00295 ! orotate relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate relationship: part_of UPa:UPA00070 {cardinality="1"} ! UMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00070 ! UMP biosynthesis via de novo pathway [Term] id: UPa:ULS00481 name: orotate from (S)-dihydroorotate (quinone route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00295 ! orotate relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate relationship: part_of UPa:UPA00070 {cardinality="1"} ! UMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00070 ! UMP biosynthesis via de novo pathway [Term] id: UPa:ULS00482 name: UMP from orotate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00295 {cardinality="1"} ! orotate relationship: has_input_compound UPa:UPC00295 ! orotate relationship: has_output_compound UPa:UPC00105 ! UMP relationship: has_output_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: part_of UPa:UPA00070 {cardinality="1"} ! UMP biosynthesis via de novo pathway relationship: part_of UPa:UPA00070 ! UMP biosynthesis via de novo pathway [Term] id: UPa:ULS00483 name: (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_output_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate relationship: part_of UPa:UPA00122 ! L-tyrosine biosynthesis relationship: part_of UPa:UPA00122 {cardinality="1"} ! L-tyrosine biosynthesis [Term] id: UPa:ULS00484 name: (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: has_input_compound UPa:UPC00254 ! prephenate relationship: has_output_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate relationship: part_of UPa:UPA00122 ! L-tyrosine biosynthesis relationship: part_of UPa:UPA00122 {cardinality="1"} ! L-tyrosine biosynthesis [Term] id: UPa:ULS00485 name: L-tyrosine from (4-hydroxyphenyl)pyruvate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate relationship: has_input_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: part_of UPa:UPA00122 ! L-tyrosine biosynthesis relationship: part_of UPa:UPA00122 {cardinality="1"} ! L-tyrosine biosynthesis [Term] id: UPa:ULS00486 name: L-tyrosine from L-arogenate (NAD(+) route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_input_compound UPa:UPC00826 ! L-arogenate relationship: has_output_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: part_of UPa:UPA00122 ! L-tyrosine biosynthesis relationship: part_of UPa:UPA00122 {cardinality="1"} ! L-tyrosine biosynthesis [Term] id: UPa:ULS00487 name: L-tyrosine from L-arogenate (NADP(+) route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_input_compound UPa:UPC00826 ! L-arogenate relationship: has_output_compound UPa:UPC00082 ! L-tyrosine relationship: has_output_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: part_of UPa:UPA00122 ! L-tyrosine biosynthesis relationship: part_of UPa:UPA00122 {cardinality="1"} ! L-tyrosine biosynthesis [Term] id: UPa:ULS00488 name: 2-oxoglutarate from isocitrate (NADP(+) route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00311 ! isocitrate relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle [Term] id: UPa:ULS00489 name: 2-oxoglutarate from isocitrate (NAD(+) route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00311 ! isocitrate relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle [Term] id: UPa:ULS00490 name: succinyl-CoA from 2-oxoglutarate (dehydrogenase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle [Term] id: UPa:ULS00491 name: succinyl-CoA from 2-oxoglutarate (synthase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00091 ! succinyl-CoA relationship: has_output_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle [Term] id: UPa:ULS00492 name: succinate from succinyl-CoA (ligase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle [Term] id: UPa:ULS00493 name: succinate from succinyl-CoA (transferase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle [Term] id: UPa:ULS00494 name: succinate from 2-oxoglutarate (transferase route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00042 ! succinate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle [Term] id: UPa:ULS00495 name: fumarate from succinate (bacterial route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00042 ! succinate relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle [Term] id: UPa:ULS00496 name: fumarate from succinate (eukaryal route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00042 ! succinate relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle [Term] id: UPa:ULS00497 name: (S)-malate from fumarate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: has_input_compound UPa:UPC00122 ! fumarate relationship: has_output_compound UPa:UPC00149 ! (S)-malate relationship: has_output_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle [Term] id: UPa:ULS00498 name: oxaloacetate from (S)-malate (quinone route) namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate relationship: has_input_compound UPa:UPC00149 ! (S)-malate relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: has_output_compound UPa:UPC00036 ! oxaloacetate relationship: part_of UPa:UPA00223 ! tricarboxylic acid cycle relationship: part_of UPa:UPA00223 {cardinality="1"} ! tricarboxylic acid cycle [Term] id: UPa:ULS00499 name: riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC04732 {cardinality="1"} ! 5-amino-6-(D-ribitylamino)uracil relationship: has_input_compound UPa:UPC04732 ! 5-amino-6-(D-ribitylamino)uracil relationship: has_input_compound UPa:UPC15556 {cardinality="1"} ! 2-hydroxy-3-oxobutyl phosphate relationship: has_input_compound UPa:UPC15556 ! 2-hydroxy-3-oxobutyl phosphate relationship: has_output_compound UPa:UPC00255 ! riboflavin relationship: has_output_compound UPa:UPC00255 {cardinality="1"} ! riboflavin relationship: part_of UPa:UPA00275 ! riboflavin biosynthesis relationship: part_of UPa:UPA00275 {cardinality="1"} ! riboflavin biosynthesis [Term] id: UPa:ULS00500 name: beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC18068 {cardinality="1"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside relationship: has_output_compound UPa:UPC18068 ! beta-D-fructofuranosyl alpha-D-mannopyranoside relationship: part_of UPa:UPA01006 ! mannosylfructose biosynthesis relationship: part_of UPa:UPA01006 {cardinality="1"} ! mannosylfructose biosynthesis [Term] id: UPa:ULS00501 name: 6-hydroxynicotinate from nicotinate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00253 ! nicotinate relationship: has_input_compound UPa:UPC00253 {cardinality="1"} ! nicotinate relationship: has_output_compound UPa:UPC01020 ! 6-hydroxynicotinate relationship: has_output_compound UPa:UPC01020 {cardinality="1"} ! 6-hydroxynicotinate relationship: part_of UPa:UPA01010 ! nicotinate degradation relationship: part_of UPa:UPA01010 {cardinality="1"} ! nicotinate degradation [Term] id: UPa:ULS00502 name: propanoate and pyruvate from 6-hydroxynicotinate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC01020 ! 6-hydroxynicotinate relationship: has_input_compound UPa:UPC01020 {cardinality="1"} ! 6-hydroxynicotinate relationship: has_output_compound UPa:UPC00022 ! pyruvate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00163 ! propanoate relationship: has_output_compound UPa:UPC00163 {cardinality="1"} ! propanoate relationship: part_of UPa:UPA01010 ! nicotinate degradation relationship: part_of UPa:UPA01010 {cardinality="1"} ! nicotinate degradation [Term] id: UPa:ULS00503 name: 4-hydroxybenzoate from 4-chlorobenzoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC02370 {cardinality="1"} ! 4-chlorobenzoate relationship: has_input_compound UPa:UPC02370 ! 4-chlorobenzoate relationship: has_output_compound UPa:UPC00156 ! 4-hydroxybenzoate relationship: has_output_compound UPa:UPC00156 {cardinality="1"} ! 4-hydroxybenzoate relationship: part_of UPa:UPA01011 ! 4-chlorobenzoate degradation relationship: part_of UPa:UPA01011 {cardinality="1"} ! 4-chlorobenzoate degradation [Term] id: UPa:ULS00504 name: glycine from L-serine namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00065 ! L-serine relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_output_compound UPa:UPC00037 ! glycine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: part_of UPa:UPA00288 ! glycine biosynthesis relationship: part_of UPa:UPA00288 {cardinality="1"} ! glycine biosynthesis [Term] id: UPa:ULS00505 name: L-aspartate from oxaloacetate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00036 ! oxaloacetate relationship: has_input_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: has_output_compound UPa:UPC00049 ! L-aspartate relationship: has_output_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: part_of UPa:UPA01012 ! L-aspartate biosynthesis relationship: part_of UPa:UPA01012 {cardinality="1"} ! L-aspartate biosynthesis [Term] id: UPa:ULS00506 name: L-glutamine from L-glutamate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00025 ! L-glutamate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00064 ! L-glutamine relationship: part_of UPa:UPA01013 ! L-glutamine biosynthesis relationship: part_of UPa:UPA01013 {cardinality="1"} ! L-glutamine biosynthesis [Term] id: UPa:ULS00507 name: catechol from anthranilate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00108 {cardinality="1"} ! anthranilate relationship: has_input_compound UPa:UPC00108 ! anthranilate relationship: has_output_compound UPa:UPC00090 ! catechol relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: part_of UPa:UPA01016 ! anthranilate degradation via hydroxylation relationship: part_of UPa:UPA01016 {cardinality="1"} ! anthranilate degradation via hydroxylation [Term] id: UPa:ULS00508 name: 15-cis-phytoene from geranylgeranyl diphosphate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00353 {cardinality="2"} ! geranylgeranyl diphosphate relationship: has_input_compound UPa:UPC00353 ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC05421 {cardinality="1"} ! 15-cis-phytoene relationship: has_output_compound UPa:UPC05421 ! 15-cis-phytoene relationship: part_of UPa:UPA00799 ! phytoene biosynthesis relationship: part_of UPa:UPA00799 {cardinality="1"} ! phytoene biosynthesis [Term] id: UPa:ULS00509 name: 1,4-dihydroxy-2-naphthoate from chorismate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC00251 ! chorismate relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: has_output_compound UPa:UPC03657 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoate relationship: has_output_compound UPa:UPC03657 ! 1,4-dihydroxy-2-naphthoate relationship: part_of UPa:UPA01057 ! 1,4-dihydroxy-2-naphthoate biosynthesis relationship: part_of UPa:UPA01057 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoate biosynthesis [Term] id: UPa:ULS00510 name: menaquinol from 1,4-dihydroxy-2-naphthoate namespace: linear_sub_pathway is_a: BFO:0000015 ! process is_a: UPa:ULS00000 ! linear sub-pathway relationship: has_input_compound UPa:UPC03657 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoate relationship: has_input_compound UPa:UPC03657 ! 1,4-dihydroxy-2-naphthoate relationship: has_output_compound UPa:UPC05819 ! menaquinol relationship: has_output_compound UPa:UPC05819 {cardinality="1"} ! menaquinol relationship: part_of UPa:UPA00079 {cardinality="1"} ! menaquinone biosynthesis relationship: part_of UPa:UPA00079 ! menaquinone biosynthesis [Term] id: UPa:UPA00001 name: biological process namespace: pathway def: "A process occurring in living organisms." [UPa:amorgat] xref: GO:0008150 "biological_process:biological_process" [Term] id: UPa:UPA00002 name: 2-deoxy-D-ribose 1-phosphate degradation namespace: pathway def: "This pathway provides a direct metabolic link between the deoxyribose moiety of nucleosides and central carbon metabolism, independent of the pentose phosphate cycle. Two enzymes provide this link: the phosphopentomutases (PPMs) and 2-deoxyribose 5-phosphate aldolases (DERAs). PPM isomerizes deoxyribose 1-phosphate to deoxyribose 5-phosphate. Subsequently, DERA cleaves the pentose phosphate to acetaldehyde and glyceraldehyde 3-phosphate, allowing further metabolism to obtain carbon and energy. The deoxyribose 1-phosphate is supplied by various nucleoside phosphorylases, such as thymidine phosphorylase, uridine phosphorylase and purine nucleoside phosphorylase, which release the pentose moiety from (deoxy)ribonucleosides, producing (deoxy)ribose 1-phosphate." [UPa:amorgat] xref: GO:0046386 "biological_process:deoxyribose phosphate catabolic process" xref: KEGG:map00030 "Pentose phosphate pathway" xref: PMID:15205420 xref: PMID:9226884 is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA00003 name: uridine metabolism namespace: pathway def: "Metabolism of uridine, a pyrimidine derivative compound." [UPa:amorgat] xref: GO:0046108 "biological_process:uridine metabolic process" is_a: UPa:UPA00570 ! pyrimidine metabolism relationship: uniprot_super_pathway UPa:UPA00313 ! pyrimidine nucleotide metabolism [Term] id: UPa:UPA00004 name: thymidine metabolism namespace: pathway def: "Metabolism of thymidine (deoxythymidine, deoxyribosylthymine, thymine deoxyriboside) a pyrimidine deoxynucleoside very widely distributed." [UPa:amorgat] synonym: "5-methyluracil metabolism" EXACT [] synonym: "deoxyribosylthymine metabolism" EXACT [] synonym: "deoxythymidine metabolism" EXACT [] synonym: "thymine deoxyriboside metabolism" EXACT [] xref: GO:0046104 "biological_process:thymidine metabolic process" is_a: UPa:UPA00570 ! pyrimidine metabolism relationship: uniprot_super_pathway UPa:UPA00313 ! pyrimidine nucleotide metabolism [Term] id: UPa:UPA00005 name: 1,3-dichloropropene degradation namespace: pathway def: "Degradation of 1,3-dichloropropene. 1,3-Dichloropropene is used in organic synthesis and as a soil fumigant, it is possibly carcinogenic to humans (Group 2B)." [UPa:amorgat] synonym: "1,3-dichloropropene catabolism" EXACT [] is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00006 name: 1,2-dibromoethane degradation namespace: pathway def: "Degradation of 1,2-dibromoethane. 1,2-dibromoethane is a manufactured chemical. It also occurs naturally in small amounts in the ocean where it is formed, probably by algae and kelp. Other names for 1,2-dibromoethane are ethylene dibromide, EDB, and glycol bromide. It is possibly carcinogenic to humans (Group 2B)." [UPa:amorgat] is_a: UPa:UPA00007 ! haloalkane degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00007 name: haloalkane degradation namespace: pathway def: "Degradation of haloalkane compounds, a group of chemical compounds, consisting of alkanes, such as methane or ethane, with one or more halogens linked, such as chlorine or fluorine, making them a type of organic halide." [UPa:amorgat] synonym: "halogenalkane degradation" EXACT [] synonym: "halogenoalkane degradation" EXACT [] is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00008 name: atrazine degradation namespace: pathway def: "Degradation of atrazine (2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine), a chlorinated compound used throughout industry and agriculture. Degradation contaminates soils and persists until it is metabolized by microorganisms. A range of soil bacteria, including both Gram-negative and Gram-positive strains can degrade atrazine, utilizing it as a nitrogen and carbon source." [UPa:amorgat] synonym: "2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine degradation" EXACT [] xref: GO:0019381 "biological_process:atrazine catabolic process" xref: KEGG:map00791 "Atrazine degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:P141-PWY is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00009 name: anthocyanin biosynthesis namespace: pathway def: "Biosynthesis of anthocyanin compounds. Anthocyanins are water-soluble vacuolar flavonoid pigments that appear red to blue, according to pH. They are synthesized by organisms of the plant kingdom and bacteria. They have been observed to occur in all tissues of higher plants, providing color in leaves, stems, roots, flowers, and fruits." [UPa:amorgat] xref: GO:0009718 "biological_process:anthocyanin-containing compound biosynthetic process" is_a: UPa:UPA00154 ! flavonoid biosynthesis is_a: UPa:UPA00499 ! pigment biosynthesis relationship: uniprot_super_pathway UPa:UPA00499 ! pigment biosynthesis [Term] id: UPa:UPA00010 name: 1,3-diaminopropane biosynthesis namespace: pathway def: "Biosynthesis of polyamine 1,3-diaminopropane (trimethylenediamine, 1,3-propanediamine, DAP)." [UPa:amorgat] synonym: "propane-1,3-diamine biosynthesis" EXACT [] xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00289 ! amine and polyamine biosynthesis relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00011 name: mycobactin biosynthesis namespace: pathway def: "Biosynthesis of mycobactins, a family of membrane-associated siderophores required for Mycobacterium genus to adapt to its intracellular habitat. Mycobactins contain a salicylic acid-derived moiety." [UPa:amorgat] xref: PMID:16461464 xref: PMID:16923875 xref: PMID:17240979 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00012 name: taurine biosynthesis namespace: pathway def: "Biosynthesis of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats. Taurine is a derivative of the sulphur-containing (sulfhydryl) amino acid cysteine. Taurine is abundant in the tissues of many animals (metazoa). It is also found in plants, fungi, and some bacterial species, but at lower levels." [UPa:amorgat] synonym: "2-aminoethanesulfonic acid biosynthesis" EXACT [] synonym: "L-cysteine degradation via taurine pathway" EXACT [] xref: GO:0042412 "biological_process:taurine biosynthetic process" xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map00430 "Taurine and hypotaurine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:10461879 xref: PMID:18219548 is_a: UPa:UPA00521 ! organosulfur biosynthesis is_a: UPa:UPA00962 ! L-cysteine metabolism relationship: uniprot_super_pathway UPa:UPA00521 ! organosulfur biosynthesis [Term] id: UPa:UPA00013 name: bacillibactin biosynthesis namespace: pathway def: "Biosynthesis of catecholic siderophore 2,3-dihydroxybenzoate-glycine- threonine trimeric ester bacillibactin." [UPa:amorgat] synonym: "2,3-dihydroxybenzoate-glycine-threonine trimeric ester biosynthesis" EXACT [] synonym: "corynebactin biosynthesis" EXACT [] synonym: "itoic acid (2,3-dihydroxybenzoate (DHB)-glycine) biosynthesis" EXACT [] xref: PMID:11112781 xref: PMID:11790741 xref: PMID:12221282 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00014 name: aerobactin biosynthesis namespace: pathway def: "Biosynthesis of hydroxamate siderophore aerobactin." [UPa:amorgat] xref: GO:0019270 "biological_process:aerobactin biosynthetic process" xref: PMID:15215626 xref: PMID:2935523 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00015 name: amonabactin biosynthesis namespace: pathway def: "Biosynthesis of amonabactin a phenolate siderophore containing 2,3-dihydroxybenzoic acid (2,3-DHB)." [UPa:amorgat] xref: PMID:1830579 xref: PMID:2522922 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00016 name: anguibactin biosynthesis namespace: pathway def: "Biosynthesis of anguibactin siderophore." [UPa:amorgat] xref: PMID:15743971 xref: PMID:8021209 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00017 name: enterobactin biosynthesis namespace: pathway def: "Biosynthesis of siderophore enterobactin, a compound that transports iron from the bacterial environment into the cell cytoplasm. In Escherichia coli, the siderophore molecule enterobactin is synthesized in response to iron deprivation by formation of an amide bond between 2,3-dihydroxybenzoate (2,3-DHB) and l-serine and formation of ester linkages between three such N-acylated serine residues." [UPa:amorgat] synonym: "enterochelin biosynthesis" EXACT [] xref: GO:0009239 "biological_process:enterobactin biosynthetic process" xref: PMID:17675380 xref: PMID:9214294 xref: PMID:9485415 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00018 name: ornibactin biosynthesis namespace: pathway def: "Biosynthesis of ornibactin, a linear hydroxamate/hydroxycarboxylate siderophore similar in structure to the pyoverdines." [UPa:amorgat] xref: PMID:11244059 xref: PMID:16672617 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00019 name: pyoverdin biosynthesis namespace: pathway def: "Biosynthesis of pyoverdin (fluorescein, psudobactin), a yellow-green fluorescent siderophore. It is similar in structure to ornibactin." [UPa:amorgat] synonym: "fluorescein biosynthesis" EXACT [] synonym: "pseudobactin biosynthesis" EXACT [] xref: GO:0002049 "biological_process:pyoverdine biosynthetic process" xref: PMID:12686626 xref: PMID:7651323 xref: PMID:8636031 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00020 name: rhizobactin biosynthesis namespace: pathway def: "Biosynthesis of rhizobactin, an hydroxymate siderophore produced by Sinorhizobium meliloti." [UPa:amorgat] xref: GO:0019289 "biological_process:rhizobactin 1021 biosynthetic process" xref: MetaCyc:PWY-761 xref: PMID:11274118 xref: PMID:15899411 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00021 name: vulnibactin biosynthesis namespace: pathway def: "Biosynthesis of phenolate siderophore vulnibactin. Vulnibactin is produced by Vibrio vulnificus, a human pathogen. Vulnibactin is characterized as containing one residue of 2,3-dihydroxybenzoic acid as well as two residues of salicylic acid, both of which are involved in the formation of oxazoline rings with L-threonine bound to a norspermidine backbone." [UPa:amorgat] xref: PMID:8148612 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00022 name: vibriobactin biosynthesis namespace: pathway def: "Biosynthesis of peptide vibriobactin siderophore. Vibriobactin is produced by the pathogenic Vibrio cholerae. It is assembled by a four-subunit nonribosomal peptide synthetase complex, VibE, VibB, VibH, and VibF, using 2,3-dihydroxybenzoate and L-threonine as precursors to two 2,3-dihydroxyphenyl- methyloxazolinyl groups in amide linkage on a norspermidine scaffold." [UPa:amorgat] xref: GO:0019537 "biological_process:vibriobactin biosynthetic process" xref: PMID:11112537 xref: PMID:11112538 xref: PMID:11160122 xref: PMID:11524010 xref: PMID:9371453 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00023 name: alcaligin biosynthesis namespace: pathway def: "Biosynthesis of dihydroxamate siderophore alcaligin (Alc), a cyclic dimer of succinyl-N-hydroxy-C-hydroxy-putrescine. Alcaligin is produced by Bordetella bronchiseptica, a Gram- coccobacillus that causes upper respiratory tract illness in several mammalian hostsability to acquire Fe from the mammalian host is associated with virulence." [UPa:amorgat] xref: PMID:8550442 xref: PMID:8759851 xref: PMID:9266668 xref: PMID:9473041 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00024 name: pseudomonine biosynthesis namespace: pathway def: "Biosynthesis of pseudomonine siderophore. Pseudomonine is a isoxazolidone derivative produced by Pseudomonas fluorescens." [UPa:amorgat] xref: PMID:11222588 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00025 name: salicylate biosynthesis namespace: pathway def: "Biosynthesis of siderophore salicylic acid." [UPa:amorgat] synonym: "salicylic acid biosynthesis" EXACT [] xref: GO:0009697 "biological_process:salicylic acid biosynthetic process" xref: PMID:11222588 is_a: UPa:UPA00302 ! siderophore biosynthesis is_a: UPa:UPA00754 ! aromatic compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00026 name: metabolism namespace: pathway def: "The totality of the chemical reactions and physical changes that occur in living organisms, comprising anabolism and catabolism; may be qualified to mean the chemical reactions and physical processes undergone by a particular substance, or class of substances, in a living organism. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [UPa:amorgat] xref: GO:0008152 "biological_process:metabolic process" is_a: UPa:UPA00001 ! biological process [Term] id: UPa:UPA00027 name: xenobiotic metabolism namespace: pathway def: "Metabolism of xenobiotic. Xenibiotics are chemical substances that are foreign to the biological system. They include naturally occurring compounds, drugs, environmental agents, carcinogens, insecticides, etc." [UPa:amorgat] xref: GO:0006805 "biological_process:xenobiotic metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00028 name: (R)-pantothenate biosynthesis namespace: pathway def: "Biosynthesis of (R)-pantothenate, also called vitamin B5 or D-pantothenic acid. (R)-pantothenate results from the condensation of beta-alanine and D-pantoate. (R)-pantothenate is found in the 4'-phosphopantetheine moieties of CoA (coenzyme A) and of the acyl carrier protein of lipid synthesis. Micro- organisms and plants must synthesize pantothenate, while animals obtain this essential nutriment from their diet. Pantothenate biosynthesis pathway offers targets for developping drugs against microbial pathogen." [UPa:amorgat] synonym: "D-pantothenic acid biosynthesis" EXACT [] synonym: "pantothenate biosynthesis" EXACT [] synonym: "vitamin B5 biosynthesis" EXACT [] xref: GO:0015940 "biological_process:pantothenate biosynthetic process" xref: KEGG:map00410 "beta-Alanine metabolism" xref: KEGG:map00770 "Pantothenate and CoA biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:12773157 xref: PMID:14675432 xref: PMID:16042590 is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00029 name: staphyloxanthin biosynthesis namespace: pathway def: "Biosynthesis of staphyloxanthin. Staphyloxanthin is an orange membrane-bound carotenoid pigment produced by most Staphylococcus aureus strains. It is well known that carotenoids function as antioxidants, and it has been suggested that staphyloxanthin can protect Staphylococcus aureus against oxidative stress." [UPa:amorgat] synonym: "alpha-D-glucopyranosyl 1-O-(4,4'-diaponeurosporen-4-oate) 6-O-(12-methyltetradecanoate) biosynthesis" EXACT [] xref: KEGG:map00906 "Carotenoid biosynthesis" xref: PMID:16020541 is_a: UPa:UPA00419 ! xantophyll biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00030 name: lipopolysaccharide biosynthesis namespace: pathway def: "Biosynthesis of lipopolysaccharide (LPS). LPS comprises three parts: i) polysaccharide (O) side chains (O-antigen); ii) core oligosaccharide; iii) lipid A. Lipid A contains unusual fatty acids (e.g. hydroxy-myristic acid) and is inserted into the outer membrane while the rest of the LPS projects from the surface. Core oligosaccharide contains unusual sugars (e.g. KDO, keto-deoxyoctulonate and heptulose). It contains two glucosamine sugar derivatives each containing three fatty acids with phosphate or pyrophosphate attached. The core polysaccharide is attached to lipid A, which is also in part responsible for the toxicity of gram-negative bacteria. The polysaccharide side chain is referred as the O-antigen of the bacteria. O side chain (O-antigen) is also a polysaccharide chain that extends from the core polysaccharide. LPS are major components of the cell wall of Gram-negative bacteria, contributing greatly to the structural integrity of the bacteria, and protecting the membrane from certain kinds of chemical attack. By increasing the negative charge of the cell wall LSP helps stabilize the overall membrane structure. LPS forms the amphipathic interface between Gram-negative bacteria and their environment and contributes protection against antibiotics and the complement system. The alternative name, endotoxin, is indicative of the capacity to cause septic shock by hyperstimulation of the immune system." [UPa:amorgat] synonym: "endotoxin biosynthesis" EXACT [] synonym: "LPS biosynthesis" EXACT [] xref: GO:0009103 "biological_process:lipopolysaccharide biosynthetic process" xref: PMID:11521077 xref: PMID:12045108 xref: PMID:16953973 is_a: UPa:UPA00324 ! bacterial outer membrane biogenesis is_a: UPa:UPA00451 ! lipopolysaccharide metabolism is_a: UPa:UPA00938 ! membrane lipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00324 ! bacterial outer membrane biogenesis [Term] id: UPa:UPA00031 name: L-histidine biosynthesis namespace: pathway def: "Biosynthesis of L-histidine, (S)-alpha-Amino- 1H-imidazole-4-propionic acid, a weakly basic amino-acid in a nine- step pathway. Histidine biosynthetic pathway is present in microbes, fungi and plants. Histidine biosynthesis is unusual as a metabolic process utilizing the purine ring of ATP as a carbon and nitrogen source. Histidine biosynthesis pathway is connected to de novo purine biosynthesis pathway through imidazole glycerol phosphate synthase (IGPS) which catalyzes the fifth step and converts N-(5'-phosphoribulosys)-formimino-5-aminoimidazole-4-carboxamide ribonucleotide (PRFAR) to imidazole glycerol phosphate (ImGP) and 5'-(5-aminoimidazole-4-carboxamide) ribonucleotide (AICAR). AICAR is the entry point to the purine biosynthetic pathway." [UPa:amorgat] synonym: "(S)-alpha-Amino-1H-imidazole-4-propionic acid biosynthesis" EXACT [] synonym: "2-amino-3-(1H-imidazol-4-yl)propanoate biosynthesis" EXACT [] synonym: "2-amino-3-(1H-imidazol-4-yl)propanoic acid biosynthesis" EXACT [] xref: GO:0000105 "biological_process:histidine biosynthetic process" xref: KEGG:map00340 "Histidine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: MetaCyc:HISTSYN-PWY xref: PMID:16547652 xref: PMID:17767732 xref: PMID:8852895 xref: PMID:9742729 is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis is_a: UPa:UPA00490 ! histidine metabolism relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00032 name: UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis namespace: pathway def: "Biosynthesis of UDP-beta-(4-deoxy-4-formamido-L-arabinose) (UDP-L-Ara4FN), a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N). This latter compound is covalently linked to lipid A moiety of some pathogenic Gram-negative bacteria. This LPS modification is a strategy adopted by pathogenic Gram-negative bacteria to evade cationic antimicrobial peptides produced by the innate immune system." [UPa:amorgat] synonym: "UDP-beta-(4-deoxy-4-formamido-L-arabinose) biosynthesis" EXACT [] synonym: "UDP-L-4-formamido-arabinose biosynthesis" EXACT [] synonym: "UDP-L-Ara4FN biosynthesis" EXACT [] xref: KEGG:map00520 "Amino sugar and nucleotide sugar metabolism" xref: PMID:15695810 xref: PMID:15809294 is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00033 name: L-lysine biosynthesis via AAA pathway namespace: pathway def: "Biosynthesis of L-lysine through the alpha-amino adipic acid (AAA) pathway. It was first believed that this pathway was a specific character of fungi. In 1998, a gene cluster of a thermophilic bacterium (Thermus thermophilus) was shown to synthesize L-lysine through the AAA pathway. This pathway is present in hyperthermophilic archaea too (P. horikoshii and P. abyssi). Hence, this pathway is distributed among the three super-kingdoms as proposed by Woese and Fox in 1997 [PMID:270744]." [UPa:amorgat] synonym: "L-lysine biosynthesis via alpha aminoadipate pathway" EXACT [] synonym: "L-lysine biosynthesis via aminoadipic pathway" EXACT [] synonym: "L-lysine biosynthesis via L-2 aminoadipate pathway" EXACT [] xref: GO:0019878 "biological_process:lysine biosynthetic process via aminoadipic acid" xref: KEGG:map00300 "Lysine biosynthesis" xref: KEGG:map00310 "Lysine degradation" xref: KEGG:map00620 "Pyruvate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: MetaCyc:LYSINE-AMINOAD-PWY xref: MetaCyc:PWY-3081 xref: PMID:10613839 xref: PMID:11029074 xref: PMID:11238076 xref: PMID:11489859 xref: PMID:15522288 xref: PMID:16232683 xref: PMID:16943623 xref: PMID:270744 xref: PMID:3928261 xref: PMID:9868782 is_a: UPa:UPA00404 ! L-lysine biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00034 name: L-lysine biosynthesis via DAP pathway namespace: pathway def: "Biosynthesis of L-lysine through the diaminopimelate (DAP) pathway. <br> The L-lysine is synthesized from L-aspartate and pyruvate through diaminopimelate via four variants. <br> This pathway is utilised by most bacteria, some archaea, some fungi, some algae, and higher plants.<br> In bacteria, DAP is not only a direct precursor of lysine, but it is also an important constituent of the cell wall peptidoglycan. <br> The DAP pathway is of special interest for pharmacology, since the absence of DAP in mammalian cells allows for the use of the DAP biosynthetic genes as a bacteria-specific drug target. <br> Most bacteria use only one of the four variants, although certain bacteria, such as <i>C. glutamicum </i> and <i>Bacillus macerans</i>, possess both the succinylase and dehydrogenase pathways." [UPa:amorgat] synonym: "L-lysine biosynthesis from aspartate" EXACT [] synonym: "L-lysine biosynthesis via diaminopimelate pathway" EXACT [] xref: GO:0009089 "biological_process:lysine biosynthetic process via diaminopimelate" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map00300 "Lysine biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:DAPLYSINESYN-PWY xref: MetaCyc:PWY-2941 xref: MetaCyc:PWY-2942 xref: MetaCyc:PWY-5097 xref: PMID:11910040 xref: PMID:12948639 xref: PMID:17579770 xref: PMID:9559056 is_a: UPa:UPA00404 ! L-lysine biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00035 name: L-tryptophan biosynthesis namespace: pathway def: "Biosynthesis of the aromatic amino-acid L-tryptophan (Trp) from chorismate. This pathway is present in bacteria, fungi and plants. L-tryptophan is needed to synthesize proteins and, as a precursor, to nicotinic acid (niacin), serotonin and melatonin." [UPa:amorgat] synonym: "(S)-alpha-amino-beta-(3-indolyl)-propionic acid biosynthesis" EXACT [] synonym: "2-amino-3-(1H-indol-3-yl)propanoic acid biosynthesis" EXACT [] xref: GO:0000162 "biological_process:tryptophan biosynthetic process" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map00400 "Phenylalanine, tyrosine and tryptophan biosynthesis" xref: KEGG:map00402 "Benzoxazinoid biosynthesis" xref: KEGG:map00471 "D-Glutamine and D-glutamate metabolism" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:TRPSYN-PWY xref: PMID:11806827 xref: PMID:16794934 xref: PMID:2679363 xref: PMID:6822478 xref: PMID:7556082 xref: PMID:7773017 xref: PMID:7890741 xref: PMID:881418 is_a: UPa:UPA00224 ! tryptophan metabolism is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis is_a: UPa:UPA00525 ! aromatic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00036 name: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis namespace: pathway def: "Biosynthesis of undecaprenyl phosphate-4-deoxy-4-formamido-L-arabinose, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N). This latter compound is covalently linked to lipid A moiety of some pathogenic Gram-negative bacteria." [UPa:amorgat] synonym: "undecaprenyl phosphate-4-deoxy-4-formamido-L-arabinose biosynthesis" EXACT [] xref: GO:0036108 "biological_process:4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process" xref: KEGG:map00520 "Amino sugar and nucleotide sugar metabolism" xref: PMID:15695810 is_a: UPa:UPA00506 ! glycolipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00506 ! glycolipid biosynthesis [Term] id: UPa:UPA00037 name: 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis namespace: pathway def: "Modification of the lipid A moiety of lipopolysaccharide by the addition of the sugar 4-amino-4-deoxy-L-arabinose (L-Ara4N) is a strategy adopted by pathogenic Gram-negative bacteria to evade cationic antimicrobial peptides produced by the innate immune system." [UPa:amorgat] xref: GO:1901760 {source="rdfmatch"} xref: PMID:11535604 xref: PMID:17928292 xref: PMID:19166326 is_a: UPa:UPA00506 ! glycolipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00451 ! lipopolysaccharide metabolism [Term] id: UPa:UPA00038 name: UDP-alpha-D-glucuronate biosynthesis namespace: pathway def: "Biosynthesis of UDP-glucuronic acid (UDP-GlcUA), a precursor of glycosaminoglycan and proteoglycan synthesis. UDP-GlcUA is also a precursor of ascorbic acid." [UPa:amorgat] synonym: "UDP-GlcUA biosynthesis" EXACT [] synonym: "UDP-glucuronate biosynthesis" EXACT [] synonym: "UDP-glucuronic acid biosynthesis" EXACT [] xref: GO:0006065 "biological_process:UDP-glucuronate biosynthetic process" xref: KEGG:map00040 "Pentose and glucuronate interconversions" xref: KEGG:map00053 "Ascorbate and aldarate metabolism" xref: KEGG:map00500 "Starch and sucrose metabolism" xref: KEGG:map00520 "Amino sugar and nucleotide sugar metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00039 name: acetoin biosynthesis namespace: pathway def: "Biosynthesis of acetoin (3-hydroxy-2-butanone). Acetoin is a component of the butanediol cycle (butanediol fermentation) in microorganisms." [UPa:amorgat] synonym: "3-hydroxy-2-butanone biosynthesis" EXACT [] xref: GO:0045151 "biological_process:acetoin biosynthetic process" is_a: UPa:UPA00409 ! ketone biosynthesis relationship: uniprot_super_pathway UPa:UPA00409 ! ketone biosynthesis [Term] id: UPa:UPA00040 name: acetoin degradation namespace: pathway def: "Degradation of acetoin (3-hydroxy-2-butanone). Acetoin is a component of the butanediol cycle (butanediol fermentation) in microorganisms." [UPa:amorgat] synonym: "3-hydroxy-2-butanone degradation" EXACT [] xref: GO:0045150 "biological_process:acetoin catabolic process" is_a: UPa:UPA00410 ! ketone degradation relationship: uniprot_super_pathway UPa:UPA00410 ! ketone degradation [Term] id: UPa:UPA00041 name: D-glycero-D-manno-heptose 7-phosphate biosynthesis namespace: pathway def: "Biosynthesis of D-glycero-D-manno-heptose 5-phosphate. This carbohydrate is widely present in the lipopolysaccharide (LPS) of most Gram-negative bacteria. D-glycero-D-manno-heptose and its derivatives are sometimes also found in capsules and O antigen as well as in the glycan moieties of bacterial cell surface (S-layer) glycoproteins. D-glycero-D-manno-heptose are found in different anomeric configuration (alpha and beta)." [UPa:amorgat] xref: GO:2001061 "biological_process:D-glycero-D-manno-heptose 7-phosphate biosynthetic process" xref: PMID:11279237 xref: PMID:12101286 is_a: UPa:UPA00412 ! carbohydrate biosynthesis relationship: uniprot_super_pathway UPa:UPA00412 ! carbohydrate biosynthesis [Term] id: UPa:UPA00042 name: D-alanine biosynthesis namespace: pathway def: "Biosynthesis of D-alanine. D-alanine is used either as an energy source or as a component of bacterial cell wall, where it is directly involved in the cross-linking of adjacent peptidoglycan chains. In Gram-positive bacteria, D-alanine can also be found to variable extents in cell wall teichoic acid and lipoteichoic acid residues." [UPa:amorgat] synonym: "D-2-aminopropionic acid biosynthesis" EXACT [] xref: GO:0030632 "biological_process:D-alanine biosynthetic process" xref: KEGG:map00473 "D-Alanine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:ALADEG-PWY is_a: UPa:UPA00406 ! nonprotein amino-acid biosynthesis is_a: UPa:UPA00489 ! alanine metabolism relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00043 name: D-alanine degradation namespace: pathway def: "Degradation of D-alanine, the dextrorotatory isomer of the amino-acid alanine." [UPa:amorgat] synonym: "D-2-aminopropionic acid degradation" EXACT [] xref: GO:0055130 "biological_process:D-alanine catabolic process" xref: MetaCyc:ALADEG-PWY is_a: UPa:UPA00427 ! amino-acid degradation is_a: UPa:UPA00489 ! alanine metabolism relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00044 name: L-threonine degradation via aldolase pathway namespace: pathway def: "Degradation of L-threonine via aldolase pathway. L-threonine aldolase is a low-specificity enzyme which cleaves threonine directly into glycine and acetaldehyde ." [UPa:amorgat] synonym: "2-amino-3-hydroxybutyric acid degradation via aldolase pathway" EXACT [] xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:PWY-5436 is_a: UPa:UPA00493 ! L-threonine degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00045 name: nitrogen metabolism namespace: pathway def: "The chemical reactions and physical changes involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [UPa:amorgat] xref: GO:0006807 "biological_process:nitrogen compound metabolic process" is_a: UPa:UPA00026 ! metabolism relationship: uniprot_super_pathway UPa:UPA00426 ! energy metabolism [Term] id: UPa:UPA00046 name: L-threonine degradation via oxydo-reductase pathway namespace: pathway def: "Degradation of L-threonine via oxydo-reductase pathway. This pathway involves threonine dehydrogenase (TDH) and 2-amino-3-ketobutyrate CoA ligase (KBL). In the absence of KBL, 2-amino-3-oxobutanoate is spontaneously converted to aminoacetone." [UPa:amorgat] synonym: "2-amino-3-hydroxybutyric acid degradation via oxydo-reductase pathway" EXACT [] xref: GO:0019518 "biological_process:L-threonine catabolic process to glycine" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: MetaCyc:THREONINE-DEG2-PWY is_a: UPa:UPA00493 ! L-threonine degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00047 name: L-isoleucine biosynthesis namespace: pathway def: "Biosynthesis of L-isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, an hydrophobic branched- chain amino-acid. In most microorganisms, isoleucine is synthesized from aspartate via threonine [Umbarger, H. E. 1978. Amino-acid biosynthesis and its regulation. Annu. Rev. Biochem. 47:533-606]. However, alternative routes to isoleucine from precursors other than threonine have been reported. Some anaerobes can assimilate 2-methylbutyrate into isoleucine. The most commonly observed alternative route was a route from pyruvate and acetyl coenzyme A (acetyl-CoA) via citramalate. This 'pyruvate pathway' was initially proposed for the genus Leptospira because isotope-labeling experiments indicated that in some leptospiral strains, {alpha}-ketobutyrate was derived from pyruvate rather than threonine. Only a limited number of leptospires possess catabolic threonine dehydratase. Later, a similar observation was made with a thermophilic archaeon, Methanobacterium thermoautotrophicum, suggesting that isoleucine biosynthesis involves pyruvate as a precursor. Recently, (R)-citramalate synthase (EC 4.1.3.-) activity was demonstrated in the thermophilic archaeon Methanococcus jannaschii." [UPa:amorgat] synonym: "(2R*,3R*)-2-amino-3-methylpentanoic acid biosynthesis" EXACT [] xref: GO:0009097 "biological_process:isoleucine biosynthetic process" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00280 "Valine, leucine and isoleucine degradation" xref: KEGG:map00290 "Valine, leucine and isoleucine biosynthesis" xref: KEGG:map00660 "C5-Branched dibasic acid metabolism" xref: KEGG:map00966 "Glucosinolate biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:15292141 xref: PMID:9864346 is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00048 name: L-leucine biosynthesis namespace: pathway def: "Biosynthesis of L-leucine, 2-amino-4-methylpentanoic acid, an hydrophobic branched-chain amino- acid." [UPa:amorgat] synonym: "2-amino-4-methylpentanoic acid biosynthesis" EXACT [] xref: GO:0009098 "biological_process:leucine biosynthetic process" xref: KEGG:map00280 "Valine, leucine and isoleucine degradation" xref: KEGG:map00290 "Valine, leucine and isoleucine biosynthesis" xref: KEGG:map00620 "Pyruvate metabolism" xref: KEGG:map00966 "Glucosinolate biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:12626680 xref: PMID:16118664 is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00049 name: L-valine biosynthesis namespace: pathway def: "Biosynthesis of L-valine, 2-amino-3-methylbutanoic acid, an hydrophobic branched-chain amino- acid." [UPa:amorgat] synonym: "2-amino-3-methylbutanoic acid biosynthesis" EXACT [] xref: GO:0009099 "biological_process:valine biosynthetic process" xref: KEGG:map00010 "Glycolysis / Gluconeogenesis" xref: KEGG:map00020 "Citrate cycle (TCA cycle)" xref: KEGG:map00280 "Valine, leucine and isoleucine degradation" xref: KEGG:map00290 "Valine, leucine and isoleucine biosynthesis" xref: KEGG:map00620 "Pyruvate metabolism" xref: KEGG:map00650 "Butanoate metabolism" xref: KEGG:map00770 "Pantothenate and CoA biosynthesis" xref: KEGG:map00966 "Glucosinolate biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: MetaCyc:VALSYN-PWY is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00050 name: L-threonine biosynthesis namespace: pathway def: "Biosynthesis of L-threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [UPa:amorgat] synonym: "2-amino-3-hydroxybutyric acid biosynthesis" EXACT [] xref: GO:0009088 "biological_process:threonine biosynthetic process" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map00300 "Lysine biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00051 name: L-methionine biosynthesis via de novo pathway namespace: pathway def: "Sulfur-containing amino-acid L-methionine (2-amino-4-(methylthio)butanoic acid) is synthesized de novo by most microorganisms and plants after the initial steps of inorganic sulfate assimilation and synthesis of cysteine or homocysteine. There are two alternative pathways of methionine synthesis in microorganisms. The enterobacterial type trans-sulfuration pathway involves cystathionine as an intermediate and utilizes cysteine as the sulfur source. In contrast, the direct sulfhydrylation pathway found in yeast (Saccharomyces cerevisiae), spirochete (Leptospira meyeri) and actinomycetes (Corynebacterium glutamicum) bypasses cystathionine and uses inorganic sulfur instead. Although yeast, fungi and higher plants have both transsulfuration and direct sulfhydrylation pathways, only the bacteria C. glutamicum, B. subtilis, P. aeruginosa, P. putida and L. meyeri have been shown to have both pathways. Methionine biosynthesis is a central pathway, as it controls a large number of cellular processes such as translation of mRNA into proteins (not only as a substrate for protein elongation but also as the initiator of protein synthesis) and transmethylation reactions via the formation of S-adenosylmethionine (SAM) (cf activated methyl cycle pathway)." [UPa:amorgat] synonym: "2-amino-4-(methylthio)butanoic acid biosynthesis" EXACT [] xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map00300 "Lysine biosynthesis" xref: KEGG:map00670 "One carbon pool by folate" xref: KEGG:map00920 "Sulfur metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:10469143 xref: PMID:12845493 xref: PMID:12948640 xref: PMID:12951250 xref: PMID:15215334 is_a: UPa:UPA00903 ! L-methionine biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00052 name: L-threonine degradation via propanoate pathway namespace: pathway def: "Degradation of L-threonine via propanoate pathway. L-threonine can be catabolized non-oxidatively to propionate via 2-ketobutyrate." [UPa:amorgat] synonym: "2-amino-3-hydroxybutyric acid degradation via propanoate pathway" EXACT [] xref: GO:0070689 "biological_process:L-threonine catabolic process to propionate" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00290 "Valine, leucine and isoleucine biosynthesis" xref: KEGG:map00640 "Propanoate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:16139298 xref: PMID:9484901 is_a: UPa:UPA00493 ! L-threonine degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00053 name: chorismate biosynthesis namespace: pathway def: "Biosynthesis of chorismate, a precursor of aromatic amino-acids (tryptophan, tyrosine and phenylalanine). The biosynthesis of chorismate occurs only in plants and bacterial, not in animals." [UPa:amorgat] synonym: "shikimate pathway" EXACT [] xref: GO:0009423 "biological_process:chorismate biosynthetic process" xref: KEGG:map00400 "Phenylalanine, tyrosine and tryptophan biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:12948640 xref: PMID:12951250 xref: PMID:15215334 is_a: UPa:UPA00415 ! metabolic intermediate biosynthesis relationship: uniprot_super_pathway UPa:UPA00415 ! metabolic intermediate biosynthesis [Term] id: UPa:UPA00054 name: daunorubicin biosynthesis namespace: pathway def: "Biosynthesis of daunorubicin, a potent antitumor anthracycline antibiotics produced by Streptomyces peucetius." [UPa:amorgat] xref: GO:1901771 {source="rdfmatch"} xref: PMID:15273252 xref: PMID:7601857 is_a: UPa:UPA00127 ! anthracycline biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00055 name: CDP-3,6-dideoxy-D-mannose biosynthesis namespace: pathway def: "Biosynthesis of CDP-3,6-dideoxy-D-mannose (CDP-tyvelose), a 3,6-dideoxy nucleotide sugar. CDP-3,6-dideoxy-D-mannose is a cell wall lipopolysaccharide O-antigen component of some Gram-negative bacteria." [UPa:amorgat] synonym: "CDP-tyvelose biosynthesis" EXACT [] xref: KEGG:map00500 "Starch and sucrose metabolism" xref: KEGG:map00520 "Amino sugar and nucleotide sugar metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00056 name: isopentenyl diphosphate biosynthesis via DXP pathway namespace: pathway def: "Biosynthesis of isopentenyl-PP via deoxy xylulose phosphate (DXP) pathway. This pathway is essential in eubacteria (including Escherichia coli), the malaria parasite, and plants, but is absent in mammals. Therefore, the pathway enzymes are promising targets for the development of novel herbicides and antimicrobials that are potentially innocuous for humans." [UPa:amorgat] synonym: "IDP biosynthesis via DXP pathway" EXACT [] synonym: "IPP biosynthesis via DXP pathway" EXACT [] synonym: "isopentenyl-PP biosynthesis via deoxy xylulose phosphate pathway" EXACT [] synonym: "isopentenyl-PP biosynthesis via DXP pathway" EXACT [] synonym: "isopentenyl-PP biosynthesis via mevalonate-independent pathway" EXACT [] synonym: "isopentenyl-PP biosynthesis via non mevalonate pathway" EXACT [] synonym: "MEP pathway" EXACT [] synonym: "methylerythritol phosphate pathway" EXACT [] synonym: "Rohmer pathway" EXACT [] xref: GO:0019288 "biological_process:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway" xref: KEGG:map00900 "Terpenoid backbone biosynthesis" xref: KEGG:map01062 "Biosynthesis of terpenoids and steroids" xref: KEGG:map01066 "Biosynthesis of alkaloids derived from terpenoid and polyketide" xref: KEGG:map01070 "Biosynthesis of plant hormones" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: MetaCyc:NONMEVIPP-PWY xref: PMID:10698701 xref: PMID:11578926 xref: PMID:11752431 is_a: UPa:UPA00417 ! isopentenyl diphosphate biosynthesis relationship: uniprot_super_pathway UPa:UPA00416 ! isoprenoid biosynthesis [Term] id: UPa:UPA00057 name: isopentenyl diphosphate biosynthesis via mevalonate pathway namespace: pathway def: "Biosynthesis of isopentenyl-PP (isopentenyl diphosphate, IDP, IPP) via mevalonic acid pathway. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl-PP, the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [UPa:amorgat] synonym: "IDP biosynthesis via mevalonate pathway" EXACT [] synonym: "IPP biosynthesis via mevalonate pathway" EXACT [] synonym: "isopentenyl-PP biosynthesis via mevalonate pathway" EXACT [] synonym: "mevalonate pathway" EXACT [] synonym: "MVA pathway" EXACT [] xref: GO:0019287 "biological_process:isopentenyl diphosphate biosynthetic process, mevalonate pathway" xref: KEGG:map00900 "Terpenoid backbone biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00417 ! isopentenyl diphosphate biosynthesis relationship: uniprot_super_pathway UPa:UPA00416 ! isoprenoid biosynthesis [Term] id: UPa:UPA00058 name: (R)-mevalonate biosynthesis namespace: pathway def: "Biosynthesis of mevalonic acid, a six-carbon metabolic intermediate. In eukaryotes, it arises from linkage of two acetyl-CoAs in the mitochondrion to form acetaoacetyl-CoA (4 carbons), followed by addition of another acetyl group from a third acetyl-CoA to give 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). This latter compound is reduced by HMG-CoA reductase in the endoplasmic reticulum, using two NADPHs, with coincident loss of CoASH. HMG-CoA reductase is the most important regulatory enzyme for the cholesterol biosynthetic pathway and other isoprenoids/terpenoids. HMG-CoA reductase is a target for drugs that attempt to lower cholesterol levels in the body. One such drug is lovastatin, which inhibits the enzyme and stops endogenous synthesis of cholesterol." [UPa:amorgat] synonym: "mevalonic acid biosynthesis" EXACT [] xref: KEGG:map00071 "Fatty acid metabolism" xref: KEGG:map00072 "Synthesis and degradation of ketone bodies" xref: KEGG:map00280 "Valine, leucine and isoleucine degradation" xref: KEGG:map00310 "Lysine degradation" xref: KEGG:map00362 "Benzoate degradation" xref: KEGG:map00380 "Tryptophan metabolism" xref: KEGG:map00620 "Pyruvate metabolism" xref: KEGG:map00630 "Glyoxylate and dicarboxylate metabolism" xref: KEGG:map00640 "Propanoate metabolism" xref: KEGG:map00650 "Butanoate metabolism" xref: KEGG:map00720 "Carbon fixation pathways in prokaryotes" xref: KEGG:map00900 "Terpenoid backbone biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00415 ! metabolic intermediate biosynthesis is_a: UPa:UPA00497 ! (R)-mevalonate metabolism relationship: uniprot_super_pathway UPa:UPA00415 ! metabolic intermediate biosynthesis [Term] id: UPa:UPA00059 name: dimethylallyl diphosphate biosynthesis namespace: pathway def: "Biosynthesis of dimethylallyl-PP (DMAPP). DMAPP results from the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl-PP (IPP)." [UPa:amorgat] synonym: "dimethylallyl pyrophosphate biosynthesis" EXACT [] synonym: "dimethylallyl-PP biosynthesis" EXACT [] synonym: "DMAPP biosynthesis" EXACT [] synonym: "DMP biosynthesis" EXACT [] synonym: "isopentenyl-PP conversion to dimethylallyl-PP" EXACT [] xref: GO:0050992 "biological_process:dimethylallyl diphosphate biosynthetic process" xref: KEGG:map00900 "Terpenoid backbone biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00416 ! isoprenoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00416 ! isoprenoid biosynthesis [Term] id: UPa:UPA00060 name: thiamine diphosphate biosynthesis namespace: pathway def: "Biosynthesis of thiamin pyrophosphate (THI-PP, TPP), the active form of thiamine cofactor (vitamin B1). It has essential functions, for example in carbohydrate and branched-chain amino-acid metabolism. All organisms able to to produce THI-PP initially assemble THI-P by coupling 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole. THI-P is then converted to TPP. The two heterocyclic precursors of thiamine pyrophosphate are synthesized through independant pathways. WARNING: the DXP_MHETP_BIOS sub-pathway is temporary. It will be refined as soon as knowledge will be available." [UPa:amorgat] synonym: "thiamin diphosphate biosynthesis" EXACT [] synonym: "thiamine-PP (THI-PP)(TPP) biosynthesis" EXACT [] xref: GO:0009229 "biological_process:thiamine diphosphate biosynthetic process" xref: KEGG:map00730 "Thiamine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00840 ! thiamine metabolism relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00061 name: alpha-ribazole biosynthesis namespace: pathway def: "Biosynthesis of alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12)." [UPa:amorgat] synonym: "dimethylbenzimidazole nucleoside biosynthesis" EXACT [] synonym: "N1-(alpha-D-ribosyl)-5,6-dimethylbenzimidazole biosynthesis" EXACT [] xref: KEGG:map00860 "Porphyrin and chlorophyll metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00425 ! nucleoside biosynthesis relationship: uniprot_super_pathway UPa:UPA00425 ! nucleoside biosynthesis [Term] id: UPa:UPA00062 name: steroid biosynthesis namespace: pathway def: "The formation from simpler components of steroid compounds. A steroid is a terpenoid lipid characterized by a carbon skeleton with four fused rings, generally arranged in a 6-6-6-5 fashion. Steroids vary by the functional groups attached to these rings and the oxidation state of the rings. Hundreds of distinct steroids are found in plants, animals, and fungi. All steroids are made in cells either from the sterol lanosterol (animals and fungi) or the sterol cycloartenol (plants). Both sterols are derived from the cyclization of the triterpene squalene." [UPa:amorgat] xref: GO:0006694 "biological_process:steroid biosynthetic process" is_a: UPa:UPA00420 ! lipid biosynthesis is_a: UPa:UPA00448 ! terpene biosynthesis is_a: UPa:UPA00504 ! steroid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00063 name: cholesterol biosynthesis namespace: pathway def: "Cholesterol biosynthesis springs from a six-carbon intermediate called mevalonate. Cholesterol is found in all eukaryotic cells. Its primary function is to regulate membrane fluidity by altering the packing density of the polar membrane lipids. It is also a precursor of several hormones. Its synthesis from acetyl CoA can be separated into 5 stages, all occuring in the cytosol: - mevalonate biosynthesis, - phosphorylation and decarboxylation of mevalonate: isopentenyl-PP biosynthesis and conversion to dimethylallyl-PP - squalene biosynthesis - conversion of squalene to 7-dehydrocholesterol - cholesterol biosynthesis: cholesterol from 7-dehydrocholesterol Cholesterol is used in the body as a precursor of many other important molecules: bile acids (salts), sex steroid hormones (testosterone, estrogen), adrenal steroid hormones (cortisol, aldosterone, vitamin D)." [UPa:amorgat] xref: GO:0006695 "biological_process:cholesterol biosynthetic process" is_a: UPa:UPA00296 ! cholesterol metabolism is_a: UPa:UPA00766 ! sterol biosynthesis relationship: uniprot_super_pathway UPa:UPA00062 ! steroid biosynthesis [Term] id: UPa:UPA00064 name: 1-deoxy-D-xylulose 5-phosphate biosynthesis namespace: pathway def: "Biosynthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [UPa:amorgat] synonym: "DXP biosynthesis" EXACT [] xref: GO:0052865 "biological_process:1-deoxy-D-xylulose 5-phosphate biosynthetic process" xref: KEGG:map00900 "Terpenoid backbone biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00415 ! metabolic intermediate biosynthesis relationship: uniprot_super_pathway UPa:UPA00415 ! metabolic intermediate biosynthesis [Term] id: UPa:UPA00065 name: 5,6,7,8-tetrahydromethanopterin biosynthesis namespace: pathway def: "Biosynthesis of 5,6,7,8-tetrahydromethanopterin (H4MPT), a cofactor in methanogenesis. H4MPT is the carrier of the C1 group as it is reduced to the methyl level, before transferring to the coenzyme M." [UPa:amorgat] synonym: "H4MPT biosynthesis" EXACT [] synonym: "methanopterin biosynthesis" EXACT [] xref: PMID:15262968 xref: PMID:8639495 is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00066 name: streptomycin biosynthesis namespace: pathway def: "Biosynthesis of streptomycin, an antibiotic produced by soil bacteria of the genus Streptomyces. Streptomycin is active against both gram-positive and gram-negative bacteria. Originally isolated by Selman A. Waksman and Albert Schatz in 1947, streptomycin is effective against tubercle bacilli and is a mainstay of tuberculosis therapy. Streptomycin acts by inhibiting protein synthesis and damaging cell membranes in susceptible microorganisms." [UPa:amorgat] xref: GO:0019872 "biological_process:streptomycin biosynthetic process" is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00067 name: ectoine biosynthesis namespace: pathway def: "Biosynthesis of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), an excellent osmoprotectant. Since Galinski et al. (PMID:3838936) discovered ectoine as a compatible solute in Ectothiorhodospira halochloris, an extremely halophilic phototrophic eubacterium, it has been found to be distributed widely in nature, largely in moderately halophilic eubacteria. The biosynthetic pathway of ectoine from aspartic b-semialdehyde (ASA) was first elucidated in Halomonas elongata by purification and characterization of each enzyme involved." [UPa:amorgat] synonym: "1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid biosynthesis" EXACT [] xref: GO:0019491 "biological_process:ectoine biosynthetic process" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:P101-PWY xref: PMID:15455210 xref: PMID:16579460 xref: PMID:16802203 xref: PMID:3838936 is_a: UPa:UPA00289 ! amine and polyamine biosynthesis relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00068 name: L-arginine biosynthesis namespace: pathway def: "Biosynthesis of L-arginine, an amino-acid constituent of proteins and precursor of polyamines." [UPa:amorgat] synonym: "(S)-2-amino-5-guanidinovaleric acid biosynthesis" EXACT [] synonym: "2-amino-5-(carbamimidamido)pentanoic acid biosynthesis" EXACT [] synonym: "2-amino-5-(diaminomethylidene amino)pentanoic acid biosynthesis" EXACT [] xref: GO:0006526 "biological_process:arginine biosynthetic process" xref: KEGG:map00240 "Pyrimidine metabolism" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:11489859 xref: PMID:16432742 xref: PMID:16585758 xref: PMID:3534538 is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis is_a: UPa:UPA00429 ! L-arginine metabolism relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00069 name: 5,6,7,8-tetrahydrosarcinapterin biosynthesis namespace: pathway def: "Biosynthesis of 5,6,7,8-tetrahydrosarcinapterin (H4SPT), a modified form of H4MPT (5,6,7,8-tetrahydromethanopterin), wherein a glutamyl group linked to the 2-hydroxyglutaric acid terminus." [UPa:amorgat] synonym: "H4SPT biosynthesis" EXACT [] synonym: "sarcinapterin biosynthesis" EXACT [] is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00070 name: UMP biosynthesis via de novo pathway namespace: pathway def: "De novo biosynthesis of UMP (uridine monophosphate)." [UPa:amorgat] synonym: "de novo uridine monophosphate biosynthesis" EXACT [] xref: GO:0044205 "biological_process:'de novo' UMP biosynthetic process" xref: KEGG:map00240 "Pyrimidine metabolism" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00572 ! UMP biosynthesis relationship: uniprot_super_pathway UPa:UPA00570 ! pyrimidine metabolism [Term] id: UPa:UPA00071 name: coenzyme F420 biosynthesis namespace: pathway def: "Biosynthesis of coenzyme F420, an important cofactor involved in hydride transfer reactions in methanogenic archaea as well as methanotrophic and other bacteria. Although coenzyme F420 contains a deazaflavin moiety, it is biochemically analogous to the nicotinamide cofactors. Coenzyme F420 is involved in a variety of biochemical transformations, including methanogenesis, DNA photorepair, and degradation of nitrophenols and nitroimidazofurans, and in the biosynthesis of several secondary metabolites [PMID:16585745]. F420 is named for its intense fluorescence upon excitation with 420 nm light, the oxidized coenzyme F420 (N-(N -l-lactyl-gamma-glutamyl)-l-glutamic acid phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin) was first discovered in mycobacteria (Cousins 1960) and later purified for structural identification from the methane-producing microorganism Methanobacterium sp. strain M.o.H. (Cheeseman et al. 1972; Eirich et al. 1978). Since these original studies, F420 has been found in numerous actinomycetes and in all methanogens (Isabelle et al. 2002). [PMID:14593448]." [UPa:amorgat] xref: PMID:14593448 xref: PMID:16585745 is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00072 name: coenzyme F0 biosynthesis namespace: pathway def: "Biosynthesis of coenzyme F0 (7,8-didemethyl-8-hydroxy-5-deazariboflavin), a biosynthetic precursor of coenzyme F420. Most cyanobacteria and halophilic archaea produce a DNA photolyase enzyme that uses F0 as a coenzyme." [UPa:amorgat] synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis" EXACT [] xref: GO:1901852 {source="rdfmatch"} xref: PMID:14593448 is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00073 name: L-arginine degradation namespace: pathway def: "Degradation of L-arginine, an energy-rich amino-acid that can supply nitrogen, carbon and energy to various bacteria in a variety of environment. L-arginine can be catabolized by a large number of routes including the arginase pathway, the arginine deiminase (ADI) pathway, the arginine succinyl transferase (AST) pathway, the arginine decarboxylase (ADC), transaminase, oxidase and oxygenase pathways. These pathways often have distinctive functions." [UPa:amorgat] synonym: "(S)-2-amino-5-guanidinovaleric acid degradation" EXACT [] synonym: "2-amino-5-(carbamimidamido)pentanoic acid degradation" EXACT [] synonym: "2-amino-5-(diaminomethylidene amino)pentanoic acid degradation" EXACT [] xref: GO:0006527 "biological_process:arginine catabolic process" is_a: UPa:UPA00427 ! amino-acid degradation is_a: UPa:UPA00429 ! L-arginine metabolism relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00074 name: IMP biosynthesis via de novo pathway namespace: pathway def: "The formation from simpler components of purine nucleotide IMP (inosine 5'phosphate)." [UPa:amorgat] synonym: "de novo purine biosynthesis" EXACT [] synonym: "inosine 5'-phosphate biosynthesis via de novo pathway" EXACT [] synonym: "inosine monophosphate biosynthesis via de novo pathway" EXACT [] xref: GO:0006189 "biological_process:'de novo' IMP biosynthetic process" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00340 "Histidine metabolism" xref: KEGG:map00630 "Glyoxylate and dicarboxylate metabolism" xref: KEGG:map00670 "One carbon pool by folate" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00593 ! purine biosynthesis via de novo pathway is_a: UPa:UPA00648 ! IMP biosynthesis relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00075 name: AMP biosynthesis via de novo pathway namespace: pathway def: "The formation of AMP (adenosine monophosphate) from IMP (inosine monophosphate)." [UPa:amorgat] synonym: "adenosine monophosphate biosynthesis via de novo pathway" EXACT [] xref: GO:0044208 "biological_process:'de novo' AMP biosynthetic process" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00592 ! AMP biosynthesis is_a: UPa:UPA00593 ! purine biosynthesis via de novo pathway relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00076 name: myo-inositol degradation into acetyl-CoA namespace: pathway def: "Degradation of myo-inositol, an abundant compound in soil. Myo-Inositol is also common and essential in plants. Several micro-organisms, including model organism Bacillus subtilis (PMID:9226270), can grow on inositol as the carbon source. It was thought that bacterial inositol catabolism is only required for efficient utilization of this compound. However, the inositol dehydrogenase of Sinorhizobium fredii not only catalyses the initial reaction step of inositol catabolism but also is involved in nitrogen fixation and competitiveness to nodulate soybeans (PMID:11274120). Furthermore, MocA and MocC of Sinorhizobium meliloti which participate in degradation of rhizopine (L-3-O-methyl-scyllo-inosamine), a symbiosis- specific compound found in alfalfa nodules, exhibited significant similarities to IolG and IolE involved in inositol catabolism of B. subtilis, respectively (PMID:9226270), and the inositol catabolism pathway was tightly linked with rhizopine utilization in S. meliloti (PMID:9802033). These facts implied an interesting relationship between bacterial inositol catabolism and plant/bacteria symbiosis for nitrogen fixation." [UPa:amorgat] xref: KEGG:map00521 "Streptomycin biosynthesis" xref: KEGG:map00562 "Inositol phosphate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:11274120 xref: PMID:14993306 xref: PMID:17449687 xref: PMID:4351258 xref: PMID:9226270 xref: PMID:9802033 is_a: UPa:UPA00405 ! myo-inositol degradation relationship: uniprot_super_pathway UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00077 name: tetrahydrofolate biosynthesis namespace: pathway def: "Biosynthesis of tetrahydrofolic acid (tetrahydrofolate, THF), the active form of folic acid (vitamin B9). Folic acid is an essential vitamin (B9), which plays a key role in the methylation cycle and in DNA biosynthesis. The folic acid derivatives are made up of a pterdine ring attached to a p-aminobenzoate and a polyglutamyl chain. Tetrahydrofolic acid have C1 units enzymically attached. These C1 units (as a formyl group) are passed on to enzymes in the purine pathway that insert the C-2 and C-8 into the purine ring. A methylene group (-CH2-) attached to tetrahydrofolate is used to convert the uracil-type pyrimidine base found in RNA into the thymine base found in DNA. A further folate cofactor, i.e. 5-methyltetrahydrofolate, is involved in the remethylation of the homocysteine produced in the methylation cycle back to methionine. After activation to S-adenosylmethionine this acts as a methyl donor for the dozens of different methyltransferases present in all cells. Folate deficiency results in reduction of purine and pyrimidine biosynthesis and consequently DNA biosynthesis and cell division. Folate deficiency receives increasing attention due to its relation to cardiovascular disease and different forms of dementia. The folate pathway represents a powerful target for combating rapidly dividing systems such as cancer cells, bacteria and malaria parasites." [UPa:amorgat] synonym: "folate biosynthesis" EXACT [] synonym: "folic acid biosynthesis" EXACT [] synonym: "pteroylglutamic acid biosynthesis" EXACT [] synonym: "tetrahydrofolic acid biosynthesis" EXACT [] synonym: "THF biosynthesis" EXACT [] synonym: "vitamin B9 biosynthesis" EXACT [] xref: GO:0046654 "biological_process:tetrahydrofolate biosynthetic process" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map00471 "D-Glutamine and D-glutamate metabolism" xref: KEGG:map00670 "One carbon pool by folate" xref: KEGG:map00790 "Folate biosynthesis" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:17645794 is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00847 ! pteridine biosynthesis is_a: UPa:UPA01000 ! tetrahydrofolate metabolism relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00078 name: biotin biosynthesis namespace: pathway def: "Biosynthesis of biotin, a B-group vitamin. Biotin has essential metabolic functions as the CO2-carrying prosthetic group of selected carboxylases, decarboxylases and transcarboxylases. De novo biosynthesis pathway involved the conversion of pimeloyl-CoA (i.e 6-carboxyhexanoyl-CoA) to biotin." [UPa:amorgat] synonym: "vitamin H biosynthesis" EXACT [] xref: GO:0009102 "biological_process:biotin biosynthetic process" xref: KEGG:map00780 "Biotin metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:12527210 is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00079 name: menaquinone biosynthesis namespace: pathway def: "Biosynthesis of menaquinone (vitamine K2), a lipid-soluble molecule that belongs to the naphto-quinone family." [UPa:amorgat] synonym: "menaquinol biosynthesis" EXACT [] synonym: "vitamin K2 biosynthesis" EXACT [] xref: GO:0009234 "biological_process:menaquinone biosynthetic process" xref: PMID:23564174 is_a: UPa:UPA00829 ! quinol/quinone biosynthesis relationship: uniprot_super_pathway UPa:UPA01055 ! quinol/quinone metabolism [Term] id: UPa:UPA00080 name: methanofuran biosynthesis namespace: pathway def: "Biosynthesis of methanofuran, the first coenzyme in the methanogenic pathway used by the archaeon Methanocaldococcus jannaschii, as well as other methanogens, to reduce CO2 to methane." [UPa:amorgat] xref: GO:2001120 {source="rdfmatch"} xref: PMID:15715981 is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00081 name: D-galactonate degradation namespace: pathway def: "Degradation of D-galactonic acid." [UPa:amorgat] synonym: "D-galactonic acid degradation" EXACT [] xref: GO:0034194 "biological_process:D-galactonate catabolic process" xref: KEGG:map00052 "Galactose metabolism" xref: PMID:6194665 xref: PMID:7287628 is_a: UPa:UPA00858 ! carbohydrate acid degradation relationship: uniprot_super_pathway UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA00082 name: naphthalene degradation namespace: pathway def: "Degradation of naphtalene, an aromatic compound composed of two fused benzene rings." [UPa:amorgat] xref: GO:1901170 {source="rdfmatch"} is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00083 name: 3-chlorocatechol degradation namespace: pathway def: "Degradation of 3-chlorocatechol compound. This pathway serves a vital role in the biodegradation of toxic aromatic compounds introduced in the environment both as natural products and as industrial effluent." [UPa:amorgat] xref: GO:1901168 {source="rdfmatch"} is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00084 name: phosphatidylglycerol biosynthesis namespace: pathway def: "Biosynthesis of phosphatidylglycerol, a multifunctional phospholipid, found in the biological membranes of many organisms." [UPa:amorgat] xref: GO:0006655 "biological_process:phosphatidylglycerol biosynthetic process" xref: KEGG:map00564 "Glycerophospholipid metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:PHOSLIPSYN-PWY is_a: UPa:UPA00751 ! phospholipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00085 ! phospholipid metabolism [Term] id: UPa:UPA00085 name: phospholipid metabolism namespace: pathway def: "Metabolism of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [UPa:amorgat] xref: GO:0006644 "biological_process:phospholipid metabolic process" is_a: UPa:UPA00436 ! lipid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00086 name: alpha-glycerophosphate cycle namespace: pathway def: "The alpha-glycerophosphate cycle is essential for the production of energy for flight in insects." [UPa:amorgat] xref: GO:0006650 "biological_process:glycerophospholipid metabolic process" xref: PMID:3147213 is_a: UPa:UPA00085 ! phospholipid metabolism relationship: uniprot_super_pathway UPa:UPA00085 ! phospholipid metabolism [Term] id: UPa:UPA00087 name: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis namespace: pathway def: "Biosynthesis of 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis (PRPP). PRPP may be synthesized from ribose 5-phosphate by PRPP synthase or, alternately, by the the enzymes phosphopentomutase, ribose 1-phosphokinase (putative), and ribose 1,5-bisphosphokinase [PMID:12700258]. Under conditions when xanthosine phosphorylase is produced, the enzyme can supply ribose 1-phosphate to this second pathway." [UPa:amorgat] synonym: "PRPP biosynthesis" EXACT [] xref: GO:0006015 "biological_process:5-phosphoribose 1-diphosphate biosynthetic process" xref: KEGG:map00030 "Pentose phosphate pathway" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:12700258 is_a: UPa:UPA00415 ! metabolic intermediate biosynthesis relationship: uniprot_super_pathway UPa:UPA00415 ! metabolic intermediate biosynthesis [Term] id: UPa:UPA00088 name: 3,4-dihydroxybenzoate biosynthesis namespace: pathway def: "Biosynthesis of 3,4-dihydroxybenzoate (protocatechuate). This pathway allows use of quinate as a carbon source by its conversion to protocatechuate and subsequent metabolism by the beta-ketoadipate pathway. Quinate is an abundant plant product." [UPa:amorgat] synonym: "protocatechuate biosynthesis" EXACT [] xref: GO:0046279 "biological_process:protocatechuate biosynthetic process" xref: KEGG:map00400 "Phenylalanine, tyrosine and tryptophan biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:15691962 xref: PMID:7592351 is_a: UPa:UPA00433 ! aromatic compound metabolism relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00089 name: deoxyribonucleotide biosynthesis namespace: pathway def: "Biosynthesis of deoxyribonucleotide derivatives. compounds." [UPa:amorgat] xref: GO:0009263 "biological_process:deoxyribonucleotide biosynthetic process" is_a: UPa:UPA00424 ! nucleotide biosynthesis relationship: uniprot_super_pathway UPa:UPA00424 ! nucleotide biosynthesis [Term] id: UPa:UPA00090 name: abscisate biosynthesis namespace: pathway def: "Biosynthesis of abscisic acid (ABA), a sesquiterpenoid (15-carbon) plant hormon. Abscisic acid is partially produced via the mevalonic pathway in chloroplasts and other plastids. Because it is synthesized partially in the chloroplasts, it makes sense that biosynthesis primarily occurs in the leaves. The production of ABA is accentuated by stresses such as water loss and freezing temperatures." [UPa:amorgat] synonym: "ABA biosynthesis" EXACT [] xref: GO:0009688 "biological_process:abscisic acid biosynthetic process" is_a: UPa:UPA00438 ! plant hormone biosynthesis is_a: UPa:UPA00449 ! sesquiterpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00438 ! plant hormone biosynthesis [Term] id: UPa:UPA00091 name: photosynthesis namespace: pathway def: "Photosynthesis is a biochemical process in which plants, algae, and some bacteria harness the energy of light to produce simple nutrient molecules, such as glucose. During photosynthesis, simple sugars are produced by combining carbon dioxide and water using light (sunlight) as an energy source and producing oxygen as a by-product. Notice that some forms of photosynthesis do not release oxygen. The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. [source: GO] The carboxylation process is generally known as CO2 fixation (carbon fixation), and the oxygenation process is known as photorespiration." [UPa:amorgat] xref: GO:0015979 "biological_process:photosynthesis" is_a: UPa:UPA00426 ! energy metabolism relationship: uniprot_super_pathway UPa:UPA00426 ! energy metabolism [Term] id: UPa:UPA00092 name: electron transfer namespace: pathway def: "A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. [GO]." [UPa:amorgat] xref: GO:0022904 "biological_process:respiratory electron transport chain" is_a: UPa:UPA00426 ! energy metabolism relationship: uniprot_super_pathway UPa:UPA00426 ! energy metabolism [Term] id: UPa:UPA00093 name: abscisic acid degradation namespace: pathway def: "Degradation of plant hormone abscisic acid." [UPa:amorgat] synonym: "ABA degradation" EXACT [] xref: GO:0046345 "biological_process:abscisic acid catabolic process" is_a: UPa:UPA00439 ! plant hormone degradation relationship: uniprot_super_pathway UPa:UPA00439 ! plant hormone degradation [Term] id: UPa:UPA00094 name: fatty acid biosynthesis namespace: pathway def: "Biosynthesis of fatty acids. Fatty acids are formed by the action of Fatty acid synthases from acetyl-CoA and malonyl-CoA precursors." [UPa:amorgat] xref: GO:0006633 "biological_process:fatty acid biosynthetic process" is_a: UPa:UPA00199 ! fatty acid metabolism is_a: UPa:UPA00420 ! lipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00095 name: oleic acid biosynthesis namespace: pathway def: "Biosynthesis of oleic acids, a group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon." [UPa:amorgat] is_a: UPa:UPA00094 ! fatty acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00096 name: sulfur metabolism namespace: pathway def: "Metabolism of compound containing sulfur." [UPa:amorgat] xref: GO:0006790 "biological_process:sulfur compound metabolic process" is_a: UPa:UPA00426 ! energy metabolism relationship: uniprot_super_pathway UPa:UPA00426 ! energy metabolism [Term] id: UPa:UPA00097 name: sulfate assimilation namespace: pathway def: "The sulfate assimilation pathway leads to the biosynthesis of cysteine and methionine, and to the sulfation of proteins, carbohydrates, lipids, drugs and xenobiotics." [UPa:amorgat] xref: GO:0000103 "biological_process:sulfate assimilation" is_a: UPa:UPA00096 ! sulfur metabolism relationship: uniprot_super_pathway UPa:UPA00096 ! sulfur metabolism [Term] id: UPa:UPA00098 name: L-proline biosynthesis namespace: pathway def: "Biosynthesis of L-proline (pyrrolidine-2-carboxylic acid) biosynthesis, a chiral, cyclic amino-acid." [UPa:amorgat] synonym: "2-pyrrolidinecarboxylic acid biosynthesis" EXACT [] synonym: "pyrrolidine-2-carboxylic acid biosynthesis" EXACT [] xref: GO:0055129 "biological_process:L-proline biosynthetic process" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:14602584 xref: PMID:16337196 is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis is_a: UPa:UPA00531 ! L-proline metabolism relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00099 name: phenazine biosynthesis namespace: pathway def: "Biosynthesis of phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control." [UPa:amorgat] xref: GO:0002047 "biological_process:phenazine biosynthetic process" is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00100 name: bacilysin biosynthesis namespace: pathway def: "Biosynthesis of bacilysin (L-alanyl-(2.3-epoxycyclohexanone-4)-L-alanine). This dipeptide is one of the simplest peptide antibiotics known. It displays activity against some bacteria and fungi (Kenig and Abraham 1976; Tschen 1990). Its proposed amino-acid ligase mode of biosynthesis might offer strategies to engineer new derivatives with improved properties. Bacilysin contains an L-alanine residue at the N terminus and a non-proteinogenic amino acid, Lanticapsin, at the C terminus (Walker and Abraham 1970). Its antibiotic activity depends on the anticapsin moiety, which becomes released by peptidases (Kenig et al. 1976; Chmara et al. 1982) after bacilysin uptake into susceptible cells by a distinct peptide permease system (Perry and Abraham 1979; Chmara et al. 1981). The intracellular anticapsin then blocks the glucosamine synthetase, and hence, bacterial peptidoglycan or fungal mannoprotein biosynthesis. This leads to cell protoplasting and lysis (Whitnney and Funderburk 1970; Kenig et al. 1976; Chmara et al. 1982; Chmara 1985; Milewski 1993)." [UPa:amorgat] synonym: "L-alanyl-(2.3-epoxycyclohexanone-4)-L-alanine biosynthesis" EXACT [] xref: PMID:15609023 is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00101 name: candicidin biosynthesis namespace: pathway def: "Biosynthesis of candicidin, an aromatic polyene (heptaene) antibiotic produced by Streptomyces griseus IMRU 3570. Polyene macrolides are a group of polyketides with lactone rings of 20-44 members. Candicidin was first described by Lechevalier et al. (1953) and named antibiotic C135, although it was renamed candicidin because of its strong activity against species of Candida." [UPa:amorgat] synonym: "C135 biosynthesis" EXACT [] synonym: "candicidin D biosynthesis" EXACT [] xref: GO:1901127 {source="rdfmatch"} xref: PMID:11782498 xref: PMID:12664141 is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00473 ! polyketide biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00102 name: gramicidin S biosynthesis namespace: pathway def: "Biosynthesis of gramicidin S antibiotic. The linear pentadecapeptide gramicidin has been reported to be assembled by four large multimodular nonribosomal peptide synthetases (NRPSs), LgrABCD, that comprise 16 modules. During biosynthesis, the N-formylated 16mer peptide is bound to the peptidyl carrier protein (PCP) of the terminal module via a thioester bond to the carboxyl group of the last amino-acid glycine(16). In a first reaction the peptide is released from the protein template in an NAD(P)H-dependent reduction step catalyzed by the adjacent reductase forming an aldehyde intermediate. This aldehyde intermediate is further reduced by an aldoreductase, LgrE, in an NADPH-dependent manner to form the final product gramicidin A, N -formyl-pentadecapeptide-ethanolamine." [UPa:amorgat] synonym: "gramicidin biosynthesis" EXACT [] xref: GO:1901103 {source="rdfmatch"} xref: PMID:15938641 is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00103 name: L-sorbose degradation namespace: pathway def: "Degradation of the monosaccharide L-sorbose." [UPa:amorgat] synonym: "L-sorbose utilization" EXACT [] synonym: "L-xylo-hexulose degradation" EXACT [] xref: GO:0042850 "biological_process:L-sorbose catabolic process" xref: PMID:16134116 is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA00104 name: creatine biosynthesis namespace: pathway def: "Biosynthesis of creatine, a nitrogenous organic acid. Creatine (Cr) is synthesized by a two-step mechanism involving arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), and is taken up by cells through a specific Cr transporter, CT1 [PMID:15918910]." [UPa:amorgat] synonym: "2-(carbamimidoyl-methyl-amino)acetic acid biosynthesis" EXACT [] synonym: "methylglycocyamine biosynthesis" EXACT [] synonym: "methylguanidinoacetic acid biosynthesis" EXACT [] synonym: "N-amidinosarcosine biosynthesis" EXACT [] xref: GO:0006601 "biological_process:creatine biosynthetic process" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:11165387 xref: PMID:15918910 is_a: UPa:UPA00289 ! amine and polyamine biosynthesis relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00105 name: xenobiotic degradation namespace: pathway def: "The breakdown into simpler components of xenobiotics, chemical substances that are foreign to the biological system." [UPa:amorgat] synonym: "xenobiotic biodegradation" EXACT [] synonym: "xenobiotic catabolism" EXACT [] xref: GO:0042178 "biological_process:xenobiotic catabolic process" is_a: UPa:UPA00027 ! xenobiotic metabolism [Term] id: UPa:UPA00106 name: nicotine degradation namespace: pathway def: "Degradation of nicotine, the primary alkaloid found in tobacco plants." [UPa:amorgat] xref: GO:0019608 "biological_process:nicotine catabolic process" xref: KEGG:map00760 "Nicotinate and nicotinamide metabolism" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:16333621 xref: PMID:7815950 is_a: UPa:UPA00447 ! alkaloid degradation relationship: uniprot_super_pathway UPa:UPA00447 ! alkaloid degradation [Term] id: UPa:UPA00107 name: nicotine biosynthesis namespace: pathway def: "Biosynthesis of nicotine, the primary alkaloid found in tobacco plants." [UPa:amorgat] xref: GO:0042179 "biological_process:nicotine biosynthetic process" is_a: UPa:UPA00446 ! alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00109 name: glycolysis namespace: pathway def: "Glycolysis is a metabolic pathway found in all organisms. This pathway results in the anaerobic enzymatic conversion of D-glucose to pyruvate, resulting in energy stored in the form of adenosine triphosphate (ATP)." [UPa:amorgat] synonym: "D-glucose degradation into pyruvate" EXACT [] xref: GO:0006096 "biological_process:glycolytic process" xref: KEGG:map00010 "Glycolysis / Gluconeogenesis" xref: KEGG:map00051 "Fructose and mannose metabolism" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map00521 "Streptomycin biosynthesis" xref: KEGG:map00524 "Butirosin and neomycin biosynthesis" xref: KEGG:map00562 "Inositol phosphate metabolism" xref: KEGG:map00620 "Pyruvate metabolism" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map00710 "Carbon fixation in photosynthetic organisms" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:14993306 is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA00110 name: cocaine degradation namespace: pathway def: "Degradation of the alkaloid cocaine." [UPa:amorgat] xref: GO:0050784 "biological_process:cocaine catabolic process" is_a: UPa:UPA00447 ! alkaloid degradation relationship: uniprot_super_pathway UPa:UPA00447 ! alkaloid degradation [Term] id: UPa:UPA00111 name: myo-inositol degradation into D-glucuronate namespace: pathway def: "Irreversible degradation of myo-inositol into D-glucuronic acid." [UPa:amorgat] synonym: "inositol oxygenation pathway" EXACT [] synonym: "myo-inositol degradation into D-glucuronic acid" EXACT [] xref: KEGG:map00053 "Ascorbate and aldarate metabolism" xref: KEGG:map00562 "Inositol phosphate metabolism" xref: PMID:16634621 is_a: UPa:UPA00405 ! myo-inositol degradation relationship: uniprot_super_pathway UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00112 name: clavulanate biosynthesis namespace: pathway def: "Biosynthesis of clavulanic acid, a beta-lactam, structurally related to the penicillins, that possesses the ability to inactivate a wide range of beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. The name clavulanic acid is derived from the Streptomyces clavuligerus microorganisms from which clavulanic acid is derived. Clavulanic acid is biosynthetically generated from the amino-acid L-arginine and from pyruvate." [UPa:amorgat] xref: GO:0033050 "biological_process:clavulanic acid biosynthetic process" xref: KEGG:map00331 "Clavulanic acid biosynthesis" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:10422585 xref: PMID:10869089 xref: PMID:11988517 xref: PMID:16251194 is_a: UPa:UPA00169 ! beta-lactam biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00113 name: UDP-N-acetyl-alpha-D-glucosamine biosynthesis namespace: pathway def: "Biosynthesis of UDP-N-acetylglucosamine." [UPa:amorgat] xref: GO:0006048 "biological_process:UDP-N-acetylglucosamine biosynthetic process" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00520 "Amino sugar and nucleotide sugar metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00114 name: xylan degradation namespace: pathway def: "Degradation of xylan, a polymer of xylose residues." [UPa:amorgat] xref: GO:0045493 "biological_process:xylan catabolic process" is_a: UPa:UPA00442 ! glycan degradation relationship: uniprot_super_pathway UPa:UPA00442 ! glycan degradation [Term] id: UPa:UPA00115 name: pentose phosphate pathway namespace: pathway def: "The pentose phosphate pathway is part of central metabolism. This pathway provides a means by which glucose can be oxidized to generate NADPH and is the source of much of the NADPH that is needed for the biosynthesis of many biomolecules. The pentose phosphate pathway and the Calvin cycle have in common several enzymes and intermediates that attest to a common evolution. Like glycolysis and gluconeogenesis, these pathways are mirror images of one another: the Calvin cycle uses NADPH to reduce carbon dioxide to generate hexoses, whereas the pentose phosphate pathway breaks down glucose into carbon dioxide to generate NADPH. The Calvin cycle is sometimes referred to as the reductive pentose phosphate pathway [Stryer, Biochemistry, 2002]. For convenience, the pentose phosphate pathway is commonly divided into its preliminary oxidative stage in which glucose-6-phosphate is oxidized to ribulose-5-phosphate, and its subsequent non-oxidative stage, in which through a series of transaldolase and transketolase reactions, ribulose-5-phosphate is converted into fructose-6-phosphate and glyceraldehyde-3-phosphate." [UPa:amorgat] synonym: "hexose monophosphate pathway" EXACT [] synonym: "hexose monophosphate shunt" EXACT [] synonym: "pentose shunt" EXACT [] synonym: "phosphogluconate pathway" EXACT [] xref: GO:0006098 "biological_process:pentose-phosphate shunt" xref: KEGG:map00030 "Pentose phosphate pathway" xref: KEGG:map00040 "Pentose and glucuronate interconversions" xref: KEGG:map00480 "Glutathione metabolism" xref: KEGG:map00710 "Carbon fixation in photosynthetic organisms" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA00116 name: Calvin cycle namespace: pathway def: "In the Calvin cycle, the source of the carbon atoms is the simple molecule carbon dioxide. In this extremely important process, carbon dioxide gas is trapped in a form that is useful for many processes. The Calvin cycle brings into living systems the carbon atoms that will become constituents of nucleic acids, proteins, and fats. Photosynthetic organisms are called autotrophs (literally self- feeders) because they can synthesize glucose from carbon dioxide and water, by using sunlight as an energy source, and then recover some of this energy from the synthesized glucose through the glycolytic pathway and aerobic metabolism. Organisms that obtain energy from chemical fuels only are called heterotrophs, which ultimately depend on autotrophs for their fuel. The Calvin cycle also differs from gluconeogenesis in where it takes place in photosynthetic eukaryotes. Whereas gluconeogenesis takes place in the cytoplasm, the Calvin cycle takes place in the stroma of chloroplasts, the photosynthetic organelles. The pentose phosphate pathway is part of central metabolism. This pathway provides a means by which glucose can be oxidized to generate NADPH and is the source of much of the NADPH that is needed for the biosynthesis of many biomolecules, most notably fats. The pentose phosphate pathway and the Calvin cycle have in common several enzymes and intermediates that attest to an evolutionary kinship. Like glycolysis and gluconeogenesis, these pathways are mirror images of one another: the Calvin cycle uses NADPH to reduce carbon dioxide to generate hexoses, whereas the pentose phosphate pathway breaks down glucose into carbon dioxide to generate NADPH. The Calvin cycle is sometimes referred to as the reductive pentose phosphate pathway. [Stryer, Biochemistry, 2002]." [UPa:amorgat] synonym: "C3 photosynthesis" EXACT [] synonym: "reductive pentose phosphate cycle" EXACT [] synonym: "reductive pentose phosphate pathway" EXACT [] xref: GO:0019253 "biological_process:reductive pentose-phosphate cycle" xref: MetaCyc:CALVIN-PWY is_a: UPa:UPA00412 ! carbohydrate biosynthesis relationship: uniprot_super_pathway UPa:UPA00412 ! carbohydrate biosynthesis [Term] id: UPa:UPA00117 name: carnitine metabolism namespace: pathway def: "Metabolism of L-Carnitine (hydroxy-trimethyl aminobutyric acid), a derivative of the amino acid L-lysine. Its name is derived from the fact that it was first isolated from meat (carnus) in 1905. Because L-carnitine appeared to act as a vitamin in the mealworm (Tenebrio molitor), it was called vitamin BT. Vitamin BT turned out to be a misnomer when scientists discovered that humans and other higher organisms synthesize L-carnitine. Under certain conditions, the demand for L-carnitine may exceed an individual's capacity to synthesize it, making it a conditionally essential nutrient. L-Carnitine is synthesized primarily in the liver and also in the kidneys, and must be transported to other tissues. It is most concentrated in tissues that use fatty acids as their primary dietary fuel, such as skeletal and cardiac (heart) muscle. In this regard, L-carnitine plays an important role in energy production by chaperoning activated fatty acids (acyl-CoA) into the mitochondrial matrix for metabolism and chaperoning intermediate compounds out of the mitochondrial matrix to prevent their accumulation." [UPa:amorgat] synonym: "hydroxy-trimethyl aminobutyric acid metabolism" EXACT [] synonym: "L-Carnitine metabolism" EXACT [] xref: GO:0009437 "biological_process:carnitine metabolic process" xref: PMID:10209289 xref: PMID:11551212 xref: PMID:12081978 xref: PMID:15518548 xref: PMID:15731894 is_a: UPa:UPA00455 ! amine and polyamine metabolism relationship: uniprot_super_pathway UPa:UPA00455 ! amine and polyamine metabolism [Term] id: UPa:UPA00118 name: carnitine biosynthesis namespace: pathway def: "The formation from simpler components of carnitine (hydroxy-trimethyl aminobutyric acid). L-Carnitine is synthesized primarily in the liver and also in the kidneys, and must be transported to other tissues." [UPa:amorgat] synonym: "hydroxy-trimethyl aminobutyric acid biosynthesis" EXACT [] synonym: "L-carnitine biosynthesis" EXACT [] xref: GO:0045329 "biological_process:carnitine biosynthetic process" is_a: UPa:UPA00117 ! carnitine metabolism is_a: UPa:UPA00289 ! amine and polyamine biosynthesis relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00119 name: xanthosine degradation namespace: pathway def: "Degradation of xanthosine, a purine nucleoside." [UPa:amorgat] xref: GO:1903228 {source="rdfmatch"} is_a: UPa:UPA00607 ! purine nucleoside degradation relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00120 name: prephenate biosynthesis namespace: pathway def: "Biosynthesis of prephenate from chorismate. Prephenate is an intermediate in the biosynthesis of aromatic amino-acids, L-Phenylalanine and L-Tyrosine." [UPa:amorgat] xref: KEGG:map00400 "Phenylalanine, tyrosine and tryptophan biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00415 ! metabolic intermediate biosynthesis relationship: uniprot_super_pathway UPa:UPA00415 ! metabolic intermediate biosynthesis [Term] id: UPa:UPA00121 name: L-phenylalanine biosynthesis namespace: pathway def: "Biosynthesis of L-phenylalanine ((S)-alpha-amino-beta-phenylpropionic acid) from prephenate." [UPa:amorgat] synonym: "(S)-alpha-amino-beta-phenylpropionic acid biosynthesis" EXACT [] xref: GO:0009094 "biological_process:L-phenylalanine biosynthetic process" xref: KEGG:map00360 "Phenylalanine metabolism" xref: KEGG:map00400 "Phenylalanine, tyrosine and tryptophan biosynthesis" xref: KEGG:map00960 "Tropane, piperidine and pyridine alkaloid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis is_a: UPa:UPA00525 ! aromatic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00122 name: L-tyrosine biosynthesis namespace: pathway def: "Biosynthesis of L-tyrosine ((S)-3-(p-hydroxyphenyl)alanine) from prephenate." [UPa:amorgat] synonym: "(S)-2-amino-3-(p-hydroxyphenyl)propionic acid biosynthesis" EXACT [] synonym: "(S)-3-(p-hydroxyphenyl)alanine biosynthesis" EXACT [] xref: GO:0006571 "biological_process:tyrosine biosynthetic process" xref: KEGG:map00130 "Ubiquinone and other terpenoid-quinone biosynthesis" xref: KEGG:map00350 "Tyrosine metabolism" xref: KEGG:map00400 "Phenylalanine, tyrosine and tryptophan biosynthesis" xref: KEGG:map00401 "Novobiocin biosynthesis" xref: KEGG:map00950 "Isoquinoline alkaloid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: MetaCyc:PWY-3461 xref: MetaCyc:PWY-6120 xref: MetaCyc:TYRSYN is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis is_a: UPa:UPA00525 ! aromatic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00123 name: biopolymer modification namespace: pathway def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer, resulting in a change in its properties [GO:0043412]." [UPa:amorgat] xref: GO:0043412 "biological_process:macromolecule modification" is_a: UPa:UPA00316 ! biopolymer metabolism [Term] id: UPa:UPA00124 name: dTDP-L-rhamnose biosynthesis namespace: pathway def: "The formation from simpler components of dTDP-L-rhamnose, a substance composed of L-rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [UPa:amorgat] synonym: "dTDP-6-deoxy-L-mannose biosynthesis" EXACT [] xref: GO:0019305 "biological_process:dTDP-rhamnose biosynthetic process" is_a: UPa:UPA00412 ! carbohydrate biosynthesis relationship: uniprot_super_pathway UPa:UPA00412 ! carbohydrate biosynthesis [Term] id: UPa:UPA00125 name: L-rhamnose metabolism namespace: pathway def: "Metabolism of rhamnose (hexose 6-deoxy-L-mannose)." [UPa:amorgat] synonym: "hexose 6-deoxy-L-mannose metabolism" EXACT [] xref: GO:0019299 "biological_process:rhamnose metabolic process" is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00126 name: GDP-alpha-D-mannose biosynthesis namespace: pathway def: "The formation from simpler components of GDP-D-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [UPa:amorgat] xref: GO:0009298 "biological_process:GDP-mannose biosynthetic process" xref: KEGG:map00051 "Fructose and mannose metabolism" xref: KEGG:map00520 "Amino sugar and nucleotide sugar metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00127 name: anthracycline biosynthesis namespace: pathway def: "Biosynthesis of anthracyclines, a class of antitumor polyketide antibiotic. These compounds are used to treat a wide range of cancers, including (but not limited to) leukemias, lymphomas, and breast, uterine, ovarian, and lung cancers." [UPa:amorgat] is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00473 ! polyketide biosynthesis [Term] id: UPa:UPA00128 name: GDP-L-fucose biosynthesis via de novo pathway namespace: pathway def: "Biosynthesis of GDP-L-fucose via de novo pathway. GDP-L-fucose, the substrate for fucosyltransferases for addition of fucose to polysaccharides or glycoproteins in both procaryotes and eucaryotes, is made from GDP-D-mannose. L-Fucose is a component of bacterial surface antigens, including the extracellular polysaccharide colanic acid produced by most Escherichia coli strains, as well as by other species of the family Enterobacteriaceae. In the de novo pathway, GDP-L-fucose is synthesized from GDP-mannose via an oxidation, an epimerization, and a reduction. These steps are catalyzed by two enzymes, GDP-mannose-4,6-dehydratase and GDP-4-keto-6 -deoxy-mannose-3,5-epimerase-4-reductase (FX in mammals). In mammals, the de novo pathway is the major route for cellular GDP-L-fucose biosynthesis in vivo. Levels of GDP-L-fucose in human hepatocellular carcinoma tissues are significantly increased compared with adjacent nontumor tissues or normal livers. (relationship between elevated FX expression and increased production of GDP-L-Fucose)." [UPa:amorgat] synonym: "GDP-D-mannose to GDP-L-fucose conversion" EXACT [] xref: GO:0042351 "biological_process:'de novo' GDP-L-fucose biosynthetic process" xref: KEGG:map00051 "Fructose and mannose metabolism" xref: KEGG:map00520 "Amino sugar and nucleotide sugar metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:PWY-66 xref: PMID:14559815 xref: PMID:9525924 xref: PMID:9603974 is_a: UPa:UPA00453 ! GDP-L-fucose biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00129 name: GDP-L-fucose biosynthesis via salvage pathway namespace: pathway def: "Biosynthesis of GDP-L-fucose from L-fucose, without de novo synthesis. In the salvage pathway, GDP-L-fucose is synthesized by the action of an L-fucose kinase and GDP-L-fucose pyrophospholylase from free fucose, which is delivered to the cytosol either extracellularly or intracellularly." [UPa:amorgat] xref: GO:0042352 "biological_process:GDP-L-fucose salvage" xref: PMID:9804772 is_a: UPa:UPA00453 ! GDP-L-fucose biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00130 name: 2-(alpha-D-mannosyl)-D-glycerate biosynthesis namespace: pathway def: "Biosynthesis of alpha mannosylglycerate (MG), a compatible solute originally identified in red algae of the order Ceramiales. Mannosylglycerate is a common compatible solute of halotolerant or slightly halophilic thermophilic and hyperthermophilic prokaryotes. Mannosylglycerate has a role in stabilizing proteins from thermal denaturation, since it is one of the most efficient thermoprotectants known in vitro. The biosynthesis of MG proceeds via two alternate routes. In one pathway, GDP-mannose is condensed with D-glycerate to produce MG in a single glycosyl transfer reaction catalyzed by MG synthase. In the other pathway, mannosyl-3-phosphoglycerate synthase (MPGS) catalyzes the conversion of GDP-mannose and D-3-phosphoglycerate into mannosyl-3-phosphoglycerate (MPG), which is subsequently converted to MG by mannosyl-3-phosphoglycerate phosphatase (MPGP)." [UPa:amorgat] xref: GO:0051479 "biological_process:mannosylglycerate biosynthetic process" xref: KEGG:map00051 "Fructose and mannose metabolism" xref: PMID:10585410 xref: PMID:11562374 xref: PMID:12788726 is_a: UPa:UPA00412 ! carbohydrate biosynthesis relationship: uniprot_super_pathway UPa:UPA00412 ! carbohydrate biosynthesis [Term] id: UPa:UPA00131 name: beta-alanine biosynthesis namespace: pathway def: "Biosynthesis of beta-alanine (3-aminopropanoic acid = 3-aminopropanoate), an achiral amino-acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. It is an intermediate in pantothenic acid (vitamin B5) and coenzyme A (CoA) biosynthesis. In contrast to bacteria, yeast derive the beta-alanine required for pantothenic acid production via polyamine metabolism." [UPa:amorgat] xref: GO:0019483 "biological_process:beta-alanine biosynthetic process" xref: PMID:12586697 xref: PMID:6767707 is_a: UPa:UPA00406 ! nonprotein amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00132 name: L-ascorbate biosynthesis namespace: pathway def: "Biosynthesis of L-ascorbic acid (Asa), a sugar acid with antioxidant properties. L-ascorbate is required as a cofactor in reactions catalyzed by copper-dependent monooxygenases and iron-dependent dioxygenases. L-ascorbic acid can be biosynthesized by plants, some bacteria and many vertebrates, although not in guinea pigs and primates, including humans." [UPa:amorgat] synonym: "(2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate biosynthesis" EXACT [] synonym: "AsA biosynthesis" EXACT [] synonym: "L-ascorbic acid biosynthesis" EXACT [] synonym: "vitamin C biosynthesis" EXACT [] xref: GO:0019853 "biological_process:L-ascorbic acid biosynthetic process" xref: PMID:11153268 xref: PMID:15564123 xref: PMID:8821967 is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00412 ! carbohydrate biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00133 name: L-alanine biosynthesis namespace: pathway def: "Biosynthesis of L-alanine amino-acid." [UPa:amorgat] xref: GO:0042852 {source="rdfmatch"} is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00134 name: L-asparagine biosynthesis namespace: pathway def: "Biosynthesis of L-asparagine amino-acid." [UPa:amorgat] xref: GO:0070981 "biological_process:L-asparagine biosynthetic process" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00460 "Cyanoamino acid metabolism" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00135 name: L-serine biosynthesis namespace: pathway def: "Biosynthesis of L-serine amino-acid." [UPa:amorgat] xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:11354602 xref: PMID:16269752 xref: PMID:2982327 xref: PMID:3004357 xref: PMID:7198894 is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00136 name: L-cysteine biosynthesis namespace: pathway def: "Biosynthesis of L-cysteine amino-acid." [UPa:amorgat] xref: GO:0019344 "biological_process:cysteine biosynthetic process" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map00920 "Sulfur metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis is_a: UPa:UPA00962 ! L-cysteine metabolism relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00137 name: monoterpene degradation namespace: pathway def: "Degradation of monoterpenes. Monoterpenes can be divided into three major subgroups: linear monoterpenes, monocyclic monoterpenes and bicyclic monoterpenes." [UPa:amorgat] xref: PMID:10769172 is_a: UPa:UPA00715 ! terpenoid degradation is_a: UPa:UPA00716 ! monoterpene metabolism relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00138 name: gluconeogenesis namespace: pathway def: "Gluconeogenesis is the generation of glucose from other organic molecules like lactate, glycerol, and amino-acids. Many 3- and 4-carbon substrates can enter the gluconeogenesis pathway. But the first designated substrate in the gluconeogenic pathway is pyruvate. Gluconeogenesis cannot be considered to be a reverse process of glycolysis, as the three irreversible steps in glycolysis are bypassed in gluconeogenesis. This is done to ensure that glycolysis and gluconeogenesis do not operate at the same time in the cell." [UPa:amorgat] synonym: "glucose biosynthesis" EXACT [] xref: GO:0006094 "biological_process:gluconeogenesis" is_a: UPa:UPA00412 ! carbohydrate biosynthesis relationship: uniprot_super_pathway UPa:UPA00412 ! carbohydrate biosynthesis [Term] id: UPa:UPA00139 name: L-phenylalanine degradation namespace: pathway def: "Degradation of L-phenylalanine, an aromatic amino-acid." [UPa:amorgat] synonym: "(S)-2-amino-3-(p-hydroxyphenyl)propionic acid degradation" EXACT [] synonym: "(S)-3-(p-hydroxyphenyl)alanine degradation" EXACT [] synonym: "(S)-alpha-amino-beta-phenylpropionic acid degradation" EXACT [] synonym: "L-tyrosine degradation" EXACT [] xref: GO:0006559 "biological_process:L-phenylalanine catabolic process" xref: KEGG:map00130 "Ubiquinone and other terpenoid-quinone biosynthesis" xref: KEGG:map00350 "Tyrosine metabolism" xref: KEGG:map00360 "Phenylalanine metabolism" xref: KEGG:map00400 "Phenylalanine, tyrosine and tryptophan biosynthesis" xref: KEGG:map00401 "Novobiocin biosynthesis" xref: KEGG:map00643 "Styrene degradation" xref: KEGG:map00950 "Isoquinoline alkaloid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00427 ! amino-acid degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00140 name: hydrogen sulfide biosynthesis namespace: pathway def: "Conversion of sulfate to hydrogen sulfide, in preparation for incorporation into cysteine and methionine. Sulfate can provide sulfur for biosynthesis. The sulfur atom in sulfate is more oxidized than it is in cysteine and other organic molecules; thus sulfate must be reduced before it can be assimilated. This process is known as assimilatory sulfate reduction to distinguish it from the dissimilatory sulfate reduction that takes place when sulfate acts as an electron acceptor during anaerobic respiration." [UPa:amorgat] synonym: "assimilatory sulfate reduction" EXACT [] synonym: "sulfate activation pathway" EXACT [] synonym: "sulfate assimilation pathway" EXACT [] xref: GO:0070814 "biological_process:hydrogen sulfide biosynthetic process" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map00920 "Sulfur metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:10464198 xref: PMID:15917234 is_a: UPa:UPA00096 ! sulfur metabolism relationship: uniprot_super_pathway UPa:UPA00096 ! sulfur metabolism [Term] id: UPa:UPA00141 name: L-arabinose degradation via L-arabinono-1,4-lactone pathway namespace: pathway def: "Degradation of L-arabinose via L-arabinono-1,4-lactone pathway. In this catabolic pathway, L-arabinose is oxidized to L-arabino-gamma-lactone (L-arabinono-1,4-lactone) by a NAD(P)+-dependent dehydrogenase. The lactone is cleaved by a lactonase to L-arabonate, followed by two successive dehydration reactions forming L-2-keto-3-deoxyarabonate (L-KDA)2 and alpha-ketoglutaric semialdehyde(alpha-KGSA). The last step is the NAD(P)+-dependent dehydrogenation of alpha-KGSA to alpha-ketoglutaric acid (referred to as the first pathway). Alternatively, L-KDA is cleaved through an aldolase reaction to glycolaldehyde and pyruvate (referred to as the second pathway)." [UPa:amorgat] xref: GO:0019570 "biological_process:L-arabinose catabolic process to 2-oxoglutarate" xref: KEGG:map00040 "Pentose and glucuronate interconversions" xref: KEGG:map00053 "Ascorbate and aldarate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:PWY-5517 xref: PMID:16326697 xref: PMID:16950779 xref: PMID:17202142 is_a: UPa:UPA00463 ! L-arabinose degradation relationship: uniprot_super_pathway UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA00142 name: glutathione biosynthesis namespace: pathway def: "Biosynthesis of glutathione (GSH; L-{gamma}-glutamyl-L-cysteinylglycine), a predominant low molecular weight peptide thiol present in many Gram- negative bacteria and in virtually all eukaryotes, except those that lack mitochondria." [UPa:amorgat] synonym: "glutathione de novo biosynthesis" EXACT [] synonym: "GSH biosynthesis" EXACT [] xref: GO:0006750 "biological_process:glutathione biosynthetic process" xref: KEGG:map00480 "Glutathione metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:16339152 is_a: UPa:UPA00096 ! sulfur metabolism is_a: UPa:UPA00454 ! oligopeptide biosynthesis relationship: uniprot_super_pathway UPa:UPA00096 ! sulfur metabolism [Term] id: UPa:UPA00143 name: protein ubiquitination namespace: pathway def: "Ubiquitin is a small protein that occurs in all eukaryotic cells. Its main known function is to mark other proteins for destruction, known as proteolysis. The process of marking a protein with ubiquitin (ubiquitinylation, ubiquitylation or ubiquitination) consists of a series of steps [source: wikipedia]: 1. Activation of ubiquitin - ubiquitin is activated in a two-step reaction by an E1 ubiquitin-activating enzyme in a process requiring ATP as an energy source. The initial step involves production of a ubiquitin-adenylate intermediate. The second step transfers ubiquitin to the E1 active site cysteine residue, with release of AMP. This step results in a thioester linkage between the C-terminal carboxyl group of ubiquitin and the E1 cysteine sulfhydryl group. 2. Transfer of ubiquitin from E1 to the active site cysteine of a ubiquitin-conjugating enzyme E2 via a trans(thio)esterification reaction. 3. The final step of the ubiquitinylation cascade generally requires the activity of one of the hundreds of E3 ubiquitin-protein ligases (often termed simply ubiquitin ligase). E3 enzymes function as the substrate recognition modules of the system and are capable of interaction with both E2 and substrate. E3 enzymes possess one of two domains: * The HECT (Homologous to the E6-AP Carboxyl Terminus) domain * The RING domain (or the closely related U-box domain)." [UPa:amorgat] synonym: "protein ubiquitinylation" EXACT [] synonym: "protein ubiquitylation" EXACT [] synonym: "ubiquitin conjugation pathway" EXACT [] synonym: "Ubl conjugation pathway" EXACT [] xref: GO:0016567 "biological_process:protein ubiquitination" xref: PMID:11395416 is_a: UPa:UPA00462 ! small protein conjugation relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00144 name: proteasomal ubiquitin-dependent pathway namespace: pathway def: "Degradation of proteins by hydrolysis of their peptide bonds. This process is initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [UPa:amorgat] synonym: "ubiquitin fusion protein degradation pathway" EXACT [] synonym: "UFD pathway" EXACT [] xref: GO:0043161 "biological_process:proteasome-mediated ubiquitin-dependent protein catabolic process" is_a: UPa:UPA00468 ! protein degradation relationship: uniprot_super_pathway UPa:UPA00468 ! protein degradation [Term] id: UPa:UPA00145 name: L-arabinose degradation via L-ribulose namespace: pathway def: "Degradation of L-arabinose via L-ribulose pathway. The bacterial L-arabinose catabolic pathway consists of L-arabinose isomerase (EC 5.3.1.4), ribulokinase (EC 2.7.1.16), and L-ribulose phosphate 4-epimerase (EC 5.1.3.4) which convert L-arabinose to D-xylulose 5-phosphate. The pathway and the genes of this pathway are well-established." [UPa:amorgat] xref: GO:0019569 "biological_process:L-arabinose catabolic process to xylulose 5-phosphate" xref: KEGG:map00040 "Pentose and glucuronate interconversions" xref: KEGG:map00053 "Ascorbate and aldarate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:ARABCAT-PWY xref: PMID:3549454 xref: PMID:9084180 is_a: UPa:UPA00463 ! L-arabinose degradation relationship: uniprot_super_pathway UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA00146 name: L-arabinose degradation via L-arabinitol namespace: pathway def: "Degradation of L-arabinose via L-arabinitol pathway. The fungal L-arabinose catabolic pathway consists of aldose reductase (EC 1.1.1.21), L-arabinitol 4-dehydrogenase (EC 1.1.1.12), L-xylulose reductase (EC 1.1.1.10), D-xylulose reductase (EC 1.1.1.9), and xylulokinase (EC 2.7.1.17) which convert L-arabinose to D-xylulose 5-phosphate." [UPa:amorgat] xref: GO:0019569 "biological_process:L-arabinose catabolic process to xylulose 5-phosphate" xref: KEGG:map00040 "Pentose and glucuronate interconversions" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:PWY-5515 xref: PMID:12009906 is_a: UPa:UPA00463 ! L-arabinose degradation relationship: uniprot_super_pathway UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA00147 name: methane degradation namespace: pathway def: "Degradation of methane, the simplest alkane." [UPa:amorgat] xref: GO:0046188 "biological_process:methane catabolic process" is_a: UPa:UPA00426 ! energy metabolism relationship: uniprot_super_pathway UPa:UPA00426 ! energy metabolism [Term] id: UPa:UPA00148 name: adenosylcobalamin biosynthesis namespace: pathway def: "Biosynthesis of adenosylcobalamin (vitamin B12), a modified tetrapyrrole cofactor. Adenosylcobalamin belongs to the same class of compounds as heme, chlorophyll, siroheme, and coenzyme F430. Most prokaryotic organisms as well as animals (including human) and protists have enzyme that require adenosylcobalamin as cofactor, whereas plants and fungi are thought not to use it. It is one of the most structurally complex protein cofactors ans its biosynthesis remains one of the most enigmatic and exigent metabolic pathways in nature, requiring around 30 enzymes. Two distinct yet similar route exist, known as the oxygene-dependent (aerobic route) and oxygen-independent (anaerobic route) pathways. These pathways diverge at precorrin-2 and merge again at adenosylcobyrate. The major difference between these two routes include the timing of cobalt insertion, the requirement for oxygen and the nature of the extruded carbon fragment which is lost during the ring construction process [McGoldrick et al, 2005]." [UPa:amorgat] synonym: "vitamin B12 biosynthesis" EXACT [] xref: GO:0009236 "biological_process:cobalamin biosynthetic process" xref: KEGG:map00860 "Porphyrin and chlorophyll metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:12196148 xref: PMID:16198574 xref: PMID:16866557 is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00678 ! porphyrin-containing compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00149 name: penicillin G biosynthesis namespace: pathway def: "Biosynthesis of penicillin G, a beta-lactam antibiotic. Penicillin G is one of the mainly used antibiotics for the therapy of infectious diseases. It is produced as end product by some filamentous fungi only, most notably by Aspergillus (Emericella) nidulans and Penicillium chrysogenum. The penicillin biosynthesis is catalysed by three enzymes which are encoded by the following three genes: pcbAB (acvA), pcbC (ipnA) and penDE (aatA)." [UPa:amorgat] xref: KEGG:map00311 "Penicillin and cephalosporin biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:15719552 is_a: UPa:UPA00474 ! penicillin biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00150 name: maltose degradation namespace: pathway def: "Degradation of maltose (malt sugar), a disaccharide formed from two units of glucose joined with an alpha(1-4) linkage." [UPa:amorgat] synonym: "malt sugar degradation" EXACT [] xref: GO:0000025 "biological_process:maltose catabolic process" is_a: UPa:UPA00442 ! glycan degradation relationship: uniprot_super_pathway UPa:UPA00442 ! glycan degradation [Term] id: UPa:UPA00151 name: auxin biosynthesis namespace: pathway def: "Biosynthesis of auxins. Auxins are natural plant hormone involved in several stages of plant growth and development such as cell elongation, cell division, tissue differentiation, and apical dominance. The biosynthesis and the underlying mechanism of auxins (and cytokinins) action are subjects of intense investigation. Diverse bacterial species possess the ability to produce the auxin phytohormone indole-3-acetic acid (IAA)." [UPa:amorgat] synonym: "IAA biosynthesis" EXACT [] synonym: "indole-3-acetate biosynthesis" EXACT [] synonym: "indole-3-acetic acid biosynthesis" EXACT [] synonym: "indoleacetate biosynthesis" EXACT [] xref: GO:0009851 "biological_process:auxin biosynthetic process" xref: PMID:12758033 xref: PMID:17509086 xref: PMID:7576148 is_a: UPa:UPA00887 ! auxin metabolism relationship: uniprot_super_pathway UPa:UPA00437 ! plant hormone metabolism [Term] id: UPa:UPA00152 name: starch biosynthesis namespace: pathway def: "Biosynthesis of starch, a complex carbohydrate, used by plants as a way to store excess glucose. Starch contains a mixture of two molecules: amylose and amylopectin. Usually these are found in a ratio of 30:70 or 20:80, with amylopectin found in larger amounts than amylose. Starch is often found in the fruit, seeds, rhizomes or tubers of plants." [UPa:amorgat] xref: GO:0019252 "biological_process:starch biosynthetic process" is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00484 ! glycan biosynthesis [Term] id: UPa:UPA00153 name: starch degradation namespace: pathway def: "Degradation of starch, a complex carbohydrate, used by plants as a way to store excess glucose. Starch contains a mixture of two molecules: amylose and amylopectin. Usually these are found in a ratio of 30:70 or 20:80, with amylopectin found in larger amounts than amylose. Starch is often found in the fruit, seeds, rhizomes or tubers of plants." [UPa:amorgat] xref: GO:0005983 "biological_process:starch catabolic process" is_a: UPa:UPA00442 ! glycan degradation relationship: uniprot_super_pathway UPa:UPA00442 ! glycan degradation [Term] id: UPa:UPA00154 name: flavonoid biosynthesis namespace: pathway def: "The formation from simpler components of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [UPa:amorgat] xref: GO:0009813 "biological_process:flavonoid biosynthetic process" is_a: UPa:UPA00464 ! secondary metabolite biosynthesis is_a: UPa:UPA00709 ! flavonoid metabolism is_a: UPa:UPA00711 ! phenylpropanoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00155 name: biphenyl degradation namespace: pathway def: "Degradation of biphenyl, an aromatic hydrocarbon, comprised of two, six-sided aromatic rings connected at one carbon on each ring. It is used as a fungistat in transportation containers of oranges and other citrus fruits, as an intermediate for the production of emulsifiers, optical brighteners, plastics, crop protection products and other organic compounds. It is also used as a heat transfer medium, as a dyestuff carrier for textiles and copying paper, as a solvent in pharmaceutical production, and it was the parent compound of polychlorinated biphenyls (PCBs) (Weaver et al., 1979). Biphenyl is considered to be one of the most thermally stable organic compounds (HSDB, 1991). Animal studies have indicated that biphenyl exposure results in morphological and histopathological changes in the urinary system and it is considered to be a possible mutagen based on in-vitro studies (Boehncke et al., 2005). Various aerobic bacteria are capable of degrading biphenyl via the bhp encoded pathway (Catelani et al., 1971 and Haddock et al., 1993), which is also capable of degrading low chlorinated PCBs. [Rehmann L, Daugulis AJ., Chemosphere. 2006 May;63(6):972-9.]." [UPa:amorgat] xref: KEGG:map00621 "Dioxin degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:16310831 xref: PMID:16339959 is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00156 name: benzoate degradation via hydroxylation namespace: pathway def: "Degradation of benzoic acid via hydroxylation pathway. This aerobic pathway includes hydroxylation of the aromatic ring by monooxygenases or dioxygenases, whereby catechol (1,2-dihydroxybenzene) or protocatechuate (3,4-dihydroxybenzoate) is produced. These central aromatic intermediates are the substrates for ring-cleaving dioxygenases." [UPa:amorgat] xref: GO:0043640 "biological_process:benzoate catabolic process via hydroxylation" xref: KEGG:map00362 "Benzoate degradation" xref: KEGG:map00627 "Aminobenzoate degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00433 ! aromatic compound metabolism relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00157 name: beta-ketoadipate pathway namespace: pathway def: "The classical beta-ketoadipate pathway: ortho cleavage of catechol (1,2-dihydroxybenzene) or protocatechuate (3,4-dihydroxybenzoate) ring leads to beta-ketoadipate (3-oxoadipate), which is subsequently converted to succinyl-coenzyme A (CoA) and acetyl-CoA." [UPa:amorgat] xref: GO:0042952 "biological_process:beta-ketoadipate pathway" xref: KEGG:map00362 "Benzoate degradation" xref: KEGG:map00624 "Polycyclic aromatic hydrocarbon degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:15937168 xref: PMID:8905091 is_a: UPa:UPA00433 ! aromatic compound metabolism relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00158 name: urea cycle namespace: pathway def: "The urea cycle, also known as the ornithine cycle, is a cycle of biochemical reactions occurring in many animal organisms that produces urea from ammonia (NH4+). This cycle was the first metabolic cycle discovered (Krebs and Hensenleit, 1932) [Wikipedia]. Arginine from the diet or from protein breakdown is cleaved by the cytosolic enzyme arginase, generating urea and ornithine. In subsequent reactions of the urea cycle a new urea residue is built on the ornithine, regenerating arginine and perpetuating the cycle." [UPa:amorgat] synonym: "ornithine cycle" EXACT [] xref: GO:0000050 "biological_process:urea cycle" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00045 ! nitrogen metabolism relationship: uniprot_super_pathway UPa:UPA00045 ! nitrogen metabolism [Term] id: UPa:UPA00159 name: CTP biosynthesis via de novo pathway namespace: pathway def: "De novo biosynthesis of CTP starting from UMP." [UPa:amorgat] synonym: "cytosine triphosphate biosynthesis via de novo pathway" EXACT [] xref: GO:0044210 "biological_process:'de novo' CTP biosynthetic process" xref: KEGG:map00240 "Pyrimidine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00576 ! CTP biosynthesis relationship: uniprot_super_pathway UPa:UPA00570 ! pyrimidine metabolism [Term] id: UPa:UPA00160 name: tocopherol biosynthesis namespace: pathway def: "Biosynthesis of tocopherol, or vitamin E, a fat-soluble vitamin that is an important antioxidant. Natural vitamin E exists in eight different forms or isomers, four tocopherols and four tocotrienols. All isomers have a chromanol ring, with a hydroxyl group which can donate a hydrogen atom to reduce free radicals and a hydrophobic side chain which allows for penetration into biological membranes. There is an alpha, beta, gamma and delta form of both the tocopherols and tocotrienols, determined by the number of methyl groups on the chromanol ring. Each form has its own biological activity. Alpha-tocopherol is the most active form of vitamin E (tocopherol) in humans and is a powerful biological antioxidant." [UPa:amorgat] synonym: "vitamin E biosynthesis" EXACT [] xref: GO:0010189 "biological_process:vitamin E biosynthetic process" is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00161 name: lincomycin biosynthesis namespace: pathway def: "Biosynthesis of lincomycin A, an antibiotic that comes from the bacteria Streptomyces lincolnensis. It is composed of two moieties, a sugar moiety 6-amino-6,8-dideoxy-1-thio-D-erythro-{alpha}-D-galactooctopyranoside (methylthiolincosaminide) and an amino-acid derivative 4-n-propyl-L-hygric acid, linked by an amide bond." [UPa:amorgat] synonym: "cillimycin biosynthesis" EXACT [] synonym: "lincomycin A biosynthesis" EXACT [] xref: GO:1901774 {source="rdfmatch"} xref: PMID:15355345 xref: PMID:8577249 xref: PMID:9531633 is_a: UPa:UPA00469 ! lincosamide biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00162 name: vancomycin biosynthesis namespace: pathway def: "Biosynthesis of vancomycin, a glycopeptide antibiotic that comes from Actonobacteria. Vancomycin acts by inhibiting proper cell wall synthesis in Gram-positive bacteria. The mechanism inhibited, and various factors related to entering the outer membrane of Gram- negative organisms mean that vancomycin is not active against Gram- negative bacteria (except some non-gonococcal species of Neisseria). Specifically, vancomycin prevents incorporation of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG)-peptide subunits into the peptidoglycan matrix; which forms the major structural component of Gram-positive cell walls." [UPa:amorgat] xref: GO:0033072 "biological_process:vancomycin biosynthetic process" xref: PMID:12207020 xref: PMID:12888556 xref: PMID:15122882 is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00163 name: glycogen metabolism namespace: pathway def: "Metabolism of glycogen. This polysaccharide is the principal storage form of glucose (Glc) in animal cells. Glycogen is found in the form of granules in the cytosol in many cell types, and plays an important role in the glucose cycle." [UPa:amorgat] xref: GO:0005977 "biological_process:glycogen metabolic process" is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00484 ! glycan biosynthesis [Term] id: UPa:UPA00164 name: glycogen biosynthesis namespace: pathway def: "Biosynthesis of glycogen, the principal storage form of glucose (Glc) in animal cells. Glycogen is found in the form of granules in the cytosol in many cell types, and plays an important role in the glucose cycle." [UPa:amorgat] xref: GO:0005978 "biological_process:glycogen biosynthetic process" is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00484 ! glycan biosynthesis [Term] id: UPa:UPA00165 name: glycogen degradation namespace: pathway def: "Degradation of glycogen, the principal storage form of glucose (Glc) in animal cells. Glycogen is found in the form of granules in the cytosol in many cell types, and plays an important role in the glucose cycle." [UPa:amorgat] xref: GO:0005980 "biological_process:glycogen catabolic process" is_a: UPa:UPA00442 ! glycan degradation relationship: uniprot_super_pathway UPa:UPA00442 ! glycan degradation [Term] id: UPa:UPA00166 name: mersacidin biosynthesis namespace: pathway def: "Biosynthesis of mersacidin, a glycopeptide antibiotic that comes from Actonobacteria. Vancomycin acts by inhibiting proper cell wall synthesis in Gram-positive bacteria. The mechanism inhibited, and various factors related to entering the outer membrane of Gram- negative organisms mean that vancomycin is not active against Gram- negative bacteria (except some non-gonococcal species of Neisseria). Specifically, vancomycin prevents incorporation of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG)-peptide subunits into the peptidoglycan matrix; which forms the major structural component of Gram-positive cell walls." [UPa:amorgat] xref: PMID:10831439 is_a: UPa:UPA00472 ! lantibiotic B biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00167 name: heptaketide naphthopyrone YWA1 biosynthesis namespace: pathway def: "Biosynthesis of heptaketide naphthopyrone YWA1. yWA1 is a yellow conidial wall pigment intermediate produced by Emericella nidulans (Aspergillus nidulans)." [UPa:amorgat] xref: PMID:11251292 xref: PMID:1465094 xref: PMID:15324811 is_a: UPa:UPA00473 ! polyketide biosynthesis is_a: UPa:UPA00499 ! pigment biosynthesis relationship: uniprot_super_pathway UPa:UPA00473 ! polyketide biosynthesis [Term] id: UPa:UPA00168 name: phosphinothricin biosynthesis namespace: pathway def: "Biosynthesis of phosphinothricin (2-amino-4-(hydroxymethylphosphinyl)butanoic acid) antibiotic." [UPa:amorgat] synonym: "2-amino-4-(hydroxymethylphosphinyl)butanoic acid biosynthesis" EXACT [] xref: GO:1901766 {source="rdfmatch"} is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00169 name: beta-lactam biosynthesis namespace: pathway def: "Biosynthesis of beta-lactam antibiotics, a broad class of antibiotics which include penicillin derivatives, cephalosporins, monobactams, carbapenems and beta-lactamase inhibitors,etc (i.e any antibiotic agent which contains a beta-lactam nucleus in its molecular structure). The beta- lactam ring, or penam, is a lactam with a heteroatomic ring structure, consisting of three carbon atoms and one nitrogen atom." [UPa:amorgat] xref: GO:0030654 "biological_process:beta-lactam antibiotic biosynthetic process" is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00170 name: trisporate biosynthesis namespace: pathway def: "Biosynthesis of trisporate, a sex pheromone. Trisporate stimulates zygophore (sex cell) development in Mucor mucedo ans presumably in all other mucoraceous fungi including Blakeslea trispora. 4-dihydromethyltrisporate is produced solely by the (+) mating type and released into the environment. (-) Mating types react to the stimulus by directed growth and production of zygophores. 4-dihydromethyltrisporate is taken up by (-) hyphae and converted into methyltrisporate by 4-dihydromethyltrisporate dehydrogenase (TDH). Trisporate is synthesized from methyltrisporate by an esterase. Both enzymatic reactions occur specifically in the (-) mating type." [UPa:amorgat] xref: GO:0046842 "biological_process:trisporic acid biosynthetic process" xref: PMID:16043374 xref: PMID:4818834 xref: PMID:8828234 is_a: UPa:UPA00459 ! pheromone biosynthesis relationship: uniprot_super_pathway UPa:UPA00459 ! pheromone biosynthesis [Term] id: UPa:UPA00171 name: pentalenene biosynthesis namespace: pathway def: "Biosynthesis of pentalenene, a tricyclic sesquiterpene that is the hydrocarbon precursor of the pentalenolactone family of antibiotics. Pentalenene is produced by the cyclization of farnesyl diphosphate." [UPa:amorgat] xref: KEGG:map00909 "Sesquiterpenoid biosynthesis" is_a: UPa:UPA00974 ! pentalenolactone biosynthesis relationship: uniprot_super_pathway UPa:UPA00449 ! sesquiterpene biosynthesis [Term] id: UPa:UPA00172 name: cephalosporin C biosynthesis namespace: pathway def: "Biosynthesis of cephalosporin C antibiotic." [UPa:amorgat] xref: GO:1901268 {source="rdfmatch"} xref: PMID:11759684 xref: PMID:16332884 is_a: UPa:UPA00475 ! cephalosporin biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00173 name: actinorhodin biosynthesis namespace: pathway def: "Biosynthesis of actinorhodin polyketide antibiotic." [UPa:amorgat] synonym: "actinorhodine biosynthesis" EXACT [] xref: GO:1901112 {source="rdfmatch"} xref: PMID:15286722 xref: PMID:15458634 xref: PMID:15544323 xref: PMID:9166770 is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00473 ! polyketide biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00174 name: tetracenomycin C biosynthesis namespace: pathway def: "Biosynthesis of tetracenomycin C, a polyketide antibiotic." [UPa:amorgat] xref: GO:1901106 {source="rdfmatch"} is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00473 ! polyketide biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00175 name: granaticin biosynthesis namespace: pathway def: "Biosynthesis of granaticin, a polyketide antibiotic." [UPa:amorgat] xref: GO:1901109 {source="rdfmatch"} is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00473 ! polyketide biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00176 name: curamycin biosynthesis namespace: pathway def: "Biosynthesis of curamycin, a polyketide antibiotic." [UPa:amorgat] is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00473 ! polyketide biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00177 name: aristolochene biosynthesis namespace: pathway def: "Biosynthesis of aristolochene, a bicyclic eremophilane-type sesquiterpene. Aristolochene (+)-enantiomer is a precursor of mycotoxin PR-toxin in P.roqueforti. It is the likely parent hydrocarbon of several eremophilene toxins and bioregulators produced by a variery of filamentous fungi. The antipodal (-)-enantiomer has been isolated from numerous higher plants." [UPa:amorgat] xref: KEGG:map00909 "Sesquiterpenoid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00449 ! sesquiterpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00449 ! sesquiterpene biosynthesis [Term] id: UPa:UPA00178 name: monensin biosynthesis namespace: pathway def: "iosynthesis of monensin, a polyketide antifungal." [UPa:amorgat] xref: GO:1901730 {source="rdfmatch"} is_a: UPa:UPA00473 ! polyketide biosynthesis is_a: UPa:UPA00479 ! antifungal biosynthesis relationship: uniprot_super_pathway UPa:UPA00479 ! antifungal biosynthesis [Term] id: UPa:UPA00179 name: bacitracin biosynthesis namespace: pathway def: "Biosynthesis of bacitracin antibiotic." [UPa:amorgat] is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00180 name: tyrocidine biosynthesis namespace: pathway def: "Biosynthesis of tyrocidine antibiotic. Tyrocidine is a mixture of four cyclic decapeptides, tyrocidine A (D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr- Val-Orn-Leu), B, C, and D, in which Phe, at positions 3, 4, and Tyr residues are gradually replaced by Trp, depending on the relative concentrations of these amino-acids in the growth medium." [UPa:amorgat] xref: GO:1901904 {source="rdfmatch"} is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00181 name: surfactin biosynthesis namespace: pathway def: "Biosynthesis of surfactin antibiotic." [UPa:amorgat] is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00182 name: carbapenem biosynthesis namespace: pathway def: "Biosynthesis of carbapenem (1-carbapen-2-em-3-carboxylic acid), a beta-lactam antibiotic. biosynthesis." [UPa:amorgat] synonym: "1-carbapen-2-em-3-carboxylic acid biosynthesis" EXACT [] xref: GO:1901769 {source="rdfmatch"} xref: PMID:9402024 is_a: UPa:UPA00169 ! beta-lactam biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00183 name: cephamycin C biosynthesis namespace: pathway def: "Biosynthesis of cephamycin C, a beta-lactam antibiotic." [UPa:amorgat] xref: GO:1901118 {source="rdfmatch"} xref: MetaCyc:PWY-5633 xref: PMID:16527306 is_a: UPa:UPA00169 ! beta-lactam biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00184 name: fortimicin biosynthesis namespace: pathway def: "Biosynthesis of fortimicin A (astromicin) antibiotic." [UPa:amorgat] synonym: "astromicin biosynthesis" EXACT [] xref: PMID:8486289 is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00185 name: L-arginine degradation via AST pathway namespace: pathway def: "Degradation of L-arginine via arginine succinyl transferase pathway. One function of this pathway is to provide nitrogen during nitrogen restriction. The ammonia produced is assimilated into glutamate and glutamine, which in turn provides nitrogen for the synthesis of virtually all nitrogen-containing compounds." [UPa:amorgat] synonym: "arginine succinyl transferase (AST) pathway" EXACT [] synonym: "L-glutamate and succinate biosynthesis" EXACT [] xref: GO:0019545 "biological_process:arginine catabolic process to succinate" xref: KEGG:map00330 "Arginine and proline metabolism" xref: PMID:12003934 xref: PMID:2865249 xref: PMID:9393691 xref: PMID:9696779 is_a: UPa:UPA00073 ! L-arginine degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00186 name: agmatine biosynthesis namespace: pathway def: "The decarboxylation of L-arginine by arginine decarboxylase produces agmatine. Agmatine is a metabolic intermediate in the biosynthesis of putrescine and higher polyamines (spermidine and spermine). Recent studies indicate that agmatine can have several important biochemical effects in humans, ranging from effects on the central nervous system to cell proliferation in cancer and viral replication." [UPa:amorgat] synonym: "arginine decarboxylase pathway" EXACT [] synonym: "L-arginine degradation via ADC pathway" EXACT [] xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:12641342 xref: PMID:15656789 is_a: UPa:UPA00073 ! L-arginine degradation is_a: UPa:UPA00289 ! amine and polyamine biosynthesis relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00187 name: putrescine biosynthesis namespace: pathway def: "Biosynthesis of putrescine, an essential precursor of the higher polyamines, spermidine and spermine. Putrescine can be formed either directly from L-ornithine or from agmatine (indirectly from L-arginine)." [UPa:amorgat] xref: GO:0009446 "biological_process:putrescine biosynthetic process" xref: PMID:11673419 xref: PMID:11804860 xref: PMID:12435743 xref: PMID:12634339 is_a: UPa:UPA00289 ! amine and polyamine biosynthesis is_a: UPa:UPA00457 ! putrescine metabolism [Term] id: UPa:UPA00188 name: putrescine degradation namespace: pathway def: "Degradation of the putrescine polyamine. There are two routes of putrescine degradation to succinate semialdehyde via gamma-aminobutyric acid (GABA)." [UPa:amorgat] synonym: "1,4-butanediamine degradation" EXACT [] synonym: "1,4-diaminobutane degradation" EXACT [] synonym: "putrescine catabolism" EXACT [] synonym: "tetramethylenediamine degradation" EXACT [] xref: GO:0009447 "biological_process:putrescine catabolic process" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map00410 "beta-Alanine metabolism" xref: KEGG:map00650 "Butanoate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:12617754 xref: PMID:12634339 xref: PMID:15590624 is_a: UPa:UPA00456 ! amine and polyamine degradation is_a: UPa:UPA00457 ! putrescine metabolism relationship: uniprot_super_pathway UPa:UPA00456 ! amine and polyamine degradation [Term] id: UPa:UPA00189 name: GMP biosynthesis namespace: pathway def: "Biosynthesis of GMP (guanosine monophosphate) from IMP (inosine monophosphate)." [UPa:amorgat] synonym: "guanosine 5'-phosphate biosynthesis" EXACT [] synonym: "guanosine monophosphate biosynthesis" EXACT [] xref: GO:0006177 "biological_process:GMP biosynthetic process" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00424 ! nucleotide biosynthesis is_a: UPa:UPA00584 ! purine biosynthesis relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00190 name: B6 vitamer interconversion namespace: pathway def: "Interconversion of B6 vitamers (PL, PM, PN, PLP, PMP, PNP)." [UPa:amorgat] synonym: "vitamin B6 salvage pathway" EXACT [] xref: KEGG:map00750 "Vitamin B6 metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00191 name: alkane degradation namespace: pathway def: "Degradation of saturated hydrocarbon compounds." [UPa:amorgat] xref: GO:0043448 "biological_process:alkane catabolic process" is_a: UPa:UPA00352 ! hydrocarbon degradation relationship: uniprot_super_pathway UPa:UPA00325 ! hydrocarbon metabolism [Term] id: UPa:UPA00192 name: B6 vitamer degradation namespace: pathway def: "Degradation of B6 vitamers (PL, PM, PN)." [UPa:amorgat] synonym: "vitamin B6 degradation" EXACT [] xref: GO:0042820 "biological_process:vitamin B6 catabolic process" xref: KEGG:map00750 "Vitamin B6 metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00483 ! cofactor degradation relationship: uniprot_super_pathway UPa:UPA00483 ! cofactor degradation [Term] id: UPa:UPA00193 name: tetrahydrofolate interconversion namespace: pathway def: "C1-unit interconversion via tetrahydrofolate pathway." [UPa:amorgat] synonym: "C1-unit interconversion" EXACT [] synonym: "one carbon pool by folate pathway" EXACT [] xref: GO:0035999 "biological_process:tetrahydrofolate interconversion" xref: MetaCyc:PWY-2201 is_a: UPa:UPA00445 ! one-carbon metabolism is_a: UPa:UPA01000 ! tetrahydrofolate metabolism relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00194 name: thyroid hormone biosynthesis namespace: pathway def: "Biosynthesis of thyroid hormones. The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland. An important component in the synthesis is iodine. The major form of thyroid hormone in the blood is thyroxine (T4)." [UPa:amorgat] xref: GO:0006590 "biological_process:thyroid hormone generation" is_a: UPa:UPA00435 ! hormone biosynthesis relationship: uniprot_super_pathway UPa:UPA00435 ! hormone biosynthesis [Term] id: UPa:UPA00195 name: epi-isozizaene biosynthesis namespace: pathway def: "Biosynthesis of the tricyclic sesquiterpenoid epi-isozizaene produced by Streptomyces coelicolor." [UPa:amorgat] xref: PMID:16669656 is_a: UPa:UPA00449 ! sesquiterpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00449 ! sesquiterpene biosynthesis [Term] id: UPa:UPA00196 name: glycosylphosphatidylinositol-anchor biosynthesis namespace: pathway def: "Biosynthesis of GPI or glycosylphosphatidylinositol anchor, a glycolipid that can be attached to the C-terminus of a protein during posttranslational modification. A GPI anchor is composed of a hydrophobic phosphatidyl inositol group linked through a carbohydrate containing linker (glucosamine and mannose linked to phosphoryl ethanolamine residue) to the C-terminal amino-acid of a mature protein. The two fatty acids within the hydrophobic phosphatidyl- inositol group anchor the protein to the cell membrane." [UPa:amorgat] synonym: "GPI anchor biosynthesis" EXACT [] xref: GO:0006506 "biological_process:GPI anchor biosynthetic process" is_a: UPa:UPA00506 ! glycolipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00506 ! glycolipid biosynthesis [Term] id: UPa:UPA00197 name: bialaphos biosynthesis namespace: pathway def: "Biosynthesis of bialaphos, a secondary metabolite of Streptomyces hygroscopicus, used as herbicide. Bialaphos is a tripeptide which consists of two L-alanine residues and the L-glutamic analog phosphinothrycin." [UPa:amorgat] synonym: "2-amino-4-(methylphosphino)butyrylalanylalanine biosynthesis" EXACT [] xref: PMID:3611020 is_a: UPa:UPA00397 ! aminophosphonate biosynthesis is_a: UPa:UPA00454 ! oligopeptide biosynthesis is_a: UPa:UPA00464 ! secondary metabolite biosynthesis relationship: uniprot_super_pathway UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00198 name: DNA modification namespace: pathway def: "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. [GO]." [UPa:amorgat] xref: GO:0006304 "biological_process:DNA modification" is_a: UPa:UPA00485 ! genetic information processing relationship: uniprot_super_pathway UPa:UPA00485 ! genetic information processing [Term] id: UPa:UPA00199 name: fatty acid metabolism namespace: pathway def: "Metabolism of fatty acids." [UPa:amorgat] xref: GO:0006631 "biological_process:fatty acid metabolic process" is_a: UPa:UPA00436 ! lipid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00200 name: stilbene, coumarine and lignin biosynthesis namespace: pathway def: "Biosynthesis of stilbene, coumarine and lignin." [UPa:amorgat] is_a: UPa:UPA00464 ! secondary metabolite biosynthesis relationship: uniprot_super_pathway UPa:UPA00465 ! secondary metabolite metabolism [Term] id: UPa:UPA00201 name: L-glutamate metabolism namespace: pathway def: "Metabolism of L-glutamic acid amino-acid." [UPa:amorgat] synonym: "L-glutamic acid metabolism" EXACT [] xref: GO:0006538 "biological_process:glutamate catabolic process" is_a: UPa:UPA00401 ! amino-acid metabolism is_a: UPa:UPA00698 ! organic acid metabolism relationship: uniprot_super_pathway UPa:UPA00401 ! amino-acid metabolism [Term] id: UPa:UPA00202 name: fructose metabolism namespace: pathway def: "Metabolism of fructose." [UPa:amorgat] xref: GO:0006000 "biological_process:fructose metabolic process" is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00203 name: methylnaphthalene degradation namespace: pathway def: "Degradation of methylnaphthalene derivative compounds." [UPa:amorgat] xref: GO:0043635 "biological_process:methylnaphthalene catabolic process" is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00204 name: glutathione metabolism namespace: pathway def: "Metabolism of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. [source: GO]." [UPa:amorgat] synonym: "glutamylcysteinylglycine tripeptide metabolism" EXACT [] synonym: "GSH metabolism" EXACT [] xref: GO:0006749 "biological_process:glutathione metabolic process" is_a: UPa:UPA00096 ! sulfur metabolism relationship: uniprot_super_pathway UPa:UPA00096 ! sulfur metabolism [Term] id: UPa:UPA00205 name: propanoate metabolism namespace: pathway def: "Metabolism of propionic acid (propionate, propanoate)." [UPa:amorgat] synonym: "propionate metabolism" EXACT [] synonym: "propionic acid metabolism" EXACT [] xref: GO:0019541 {source="rdfmatch"} is_a: UPa:UPA00698 ! organic acid metabolism relationship: uniprot_super_pathway UPa:UPA00698 ! organic acid metabolism [Term] id: UPa:UPA00206 name: ethanol fermentation namespace: pathway def: "Fermentation of ethanol." [UPa:amorgat] xref: GO:0019655 {source="rdfmatch"} is_a: UPa:UPA00553 ! fermentation is_a: UPa:UPA00612 ! alcohol degradation relationship: uniprot_super_pathway UPa:UPA00553 ! fermentation [Term] id: UPa:UPA00207 name: nylon-6 oligomer degradation namespace: pathway def: "Degradation of 6-aminohexanoate dimers (cyclic or linear), by-products of nylon manufacture." [UPa:amorgat] synonym: "nylon degradation" EXACT [] xref: MetaCyc:P621-PWY xref: PMID:2512123 xref: PMID:2722746 xref: PMID:6646204 is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00208 name: 4-hydroxyphenylacetate degradation namespace: pathway def: "Degradation of 4-hydroxyphenylacetic acid." [UPa:amorgat] synonym: "4-hydroxyphenylacetic acid degradation" EXACT [] xref: KEGG:map00350 "Tyrosine metabolism" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00433 ! aromatic compound metabolism relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00209 name: geosmin biosynthesis namespace: pathway def: "Biosynthesis of geosmin (trans-1,10-dimethyl-trans-9-decalol). Geosmin is responsible for the characteristic odor of moist soil, it is produced in soil primarily by streptomycetes-ubiquitous Gram-positive, filamentous, saprophytic bacteria. Geosmin has also been isolated from a variety of cyanobacteria, fungi, and liverworts. Jiang et al [PMID:16787064] established that the biosynthesis of geosmin from farnesyl diphosphate is catalyzed by a single enzyme, the germacradienol/germacrene D synthase, without intervention of any additional enzymes and without any requirement for redox cofactors." [UPa:amorgat] synonym: "trans-1,10-dimethyl-trans-9-decalol biosynthesis" EXACT [] xref: PMID:16787064 is_a: UPa:UPA00464 ! secondary metabolite biosynthesis relationship: uniprot_super_pathway UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00210 name: purine nucleotide metabolism namespace: pathway def: "Metabolism of purine nucleotides." [UPa:amorgat] xref: GO:0006163 "biological_process:purine nucleotide metabolic process" is_a: UPa:UPA00486 ! nucleotide metabolism is_a: UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00211 name: spermine degradation namespace: pathway def: "Degradation of the polyamine spermine (N,N'-bis(3-aminopropyl)-1,4-butanediamine)." [UPa:amorgat] synonym: "N,N'-bis(3-aminopropyl)-1,4-butanediamine biosynthesis" EXACT [] xref: GO:0046208 "biological_process:spermine catabolic process" xref: PMID:12141946 is_a: UPa:UPA00456 ! amine and polyamine degradation relationship: uniprot_super_pathway UPa:UPA00456 ! amine and polyamine degradation [Term] id: UPa:UPA00212 name: polyhydroxyalkanoate biosynthesis namespace: pathway def: "Biosynthesis of polyhydroxyalkanoates (PHAs), linear polyesters produced by bacterial fermentation of sugar or lipids." [UPa:amorgat] synonym: "PHA synthesis" EXACT [] synonym: "polyhydroxyalkanoic acid synthesis" EXACT [] xref: PMID:12200450 is_a: UPa:UPA00487 ! polyester biosynthesis relationship: uniprot_super_pathway UPa:UPA00487 ! polyester biosynthesis [Term] id: UPa:UPA00213 name: terpenoid biosynthesis namespace: pathway def: "Biosynthesis of terpenoid compounds." [UPa:amorgat] xref: GO:0016114 "biological_process:terpenoid biosynthetic process" is_a: UPa:UPA00464 ! secondary metabolite biosynthesis relationship: uniprot_super_pathway UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00214 name: galactose metabolism namespace: pathway def: "Metabolism of galactose." [UPa:amorgat] xref: GO:0006012 "biological_process:galactose metabolic process" is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00215 name: nucleotide-sugar metabolism namespace: pathway def: "Metabolism of nucleotide-sugar compounds." [UPa:amorgat] xref: GO:0009225 "biological_process:nucleotide-sugar metabolic process" is_a: UPa:UPA00411 ! carbohydrate metabolism is_a: UPa:UPA00486 ! nucleotide metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00216 name: amino-sugar metabolism namespace: pathway def: "Metabolism of amino-sugar compounds." [UPa:amorgat] synonym: "amino sugar metabolism" EXACT [] synonym: "aminosugar metabolism" EXACT [] xref: GO:0006040 "biological_process:amino sugar metabolic process" is_a: UPa:UPA00411 ! carbohydrate metabolism is_a: UPa:UPA00455 ! amine and polyamine metabolism [Term] id: UPa:UPA00217 name: vanillyl-alcohol degradation namespace: pathway def: "Degradation of vanillyl-alcohol (4-hydroxy-3-methoxybenzenemethanol)." [UPa:amorgat] synonym: "4-hydroxy-3-methoxybenzenemethanol degradation" EXACT [] is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00218 name: L-methionine metabolism namespace: pathway def: "Metabolism of sulfur-containing amino-acid L-methionine (2-amino-4-(methylthio)butanoic acid). L-methionine is an essential amino-acid for many crucial cellular functions, including the initiation of protein synthesis, methylation of DNA and rRNA, and biosynthesis of cysteine, phospholipids and polyamines." [UPa:amorgat] synonym: "2-amino-4-(methylthio)butanoic acid metabolism" EXACT [] xref: GO:0006555 "biological_process:methionine metabolic process" is_a: UPa:UPA00401 ! amino-acid metabolism [Term] id: UPa:UPA00219 name: peptidoglycan biosynthesis namespace: pathway def: "Biosynthesis of peptidoglycan, also known as murein, a polymer consisting of sugars and amino-acids that forms a mesh-like layer outside the plasma membrane of eubacteria. The sugar component consists of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid residues. Attached to the N-acetylmuramic acid is a peptide chain of three to five amino-acids. The peptide chain can be cross-linked to the peptide chain of another strand forming the 3D mesh-like layer. Some Archaea have a similar layer of pseudopeptidoglycan. Peptidoglycan serves a structural role in the bacterial cell wall, giving structural strength, as well as counteracting the osmotic pressure of the cytoplasm. Peptidoglycan is also involved in binary fission during bacterial cell reproduction.[wikipedia]." [UPa:amorgat] synonym: "murein biosynthesis" EXACT [] xref: GO:0009252 "biological_process:peptidoglycan biosynthetic process" xref: PMID:SBN\:0-13-144329-1 is_a: UPa:UPA00547 ! cell wall biogenesis relationship: uniprot_super_pathway UPa:UPA00547 ! cell wall biogenesis [Term] id: UPa:UPA00220 name: phosphatidylinositol phosphate biosynthesis namespace: pathway def: "Biosynthesis of phosphatidylinositol phosphate, a class of phospholipids." [UPa:amorgat] synonym: "PIP biosynthesis" EXACT [] is_a: UPa:UPA00751 ! phospholipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00085 ! phospholipid metabolism [Term] id: UPa:UPA00221 name: bile acid biosynthesis namespace: pathway def: "Biosynthesis of bile acids, any of a group of steroid carboxylic acids occurring in bile [GO]." [UPa:amorgat] xref: GO:0006699 "biological_process:bile acid biosynthetic process" is_a: UPa:UPA00436 ! lipid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00222 name: sphingolipid metabolism namespace: pathway def: "Metabolism of sphingolipid compounds, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). There are three main types of sphingolipids: ceramides, sphingomyelins and glycosphingolipids." [UPa:amorgat] xref: GO:0006665 "biological_process:sphingolipid metabolic process" is_a: UPa:UPA00939 ! membrane lipid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00223 name: tricarboxylic acid cycle namespace: pathway def: "The tricarboxylic acid cycle (citric acid cycle, TCA cycle, Krebs cycle, or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration." [UPa:amorgat] synonym: "citric acid cycle" EXACT [] synonym: "KREBS cycle" EXACT [] synonym: "TCA cycle" EXACT [] xref: GO:0006099 "biological_process:tricarboxylic acid cycle" xref: KEGG:map00020 "Citrate cycle (TCA cycle)" xref: KEGG:map00072 "Synthesis and degradation of ketone bodies" xref: KEGG:map00280 "Valine, leucine and isoleucine degradation" xref: KEGG:map00480 "Glutathione metabolism" xref: KEGG:map00620 "Pyruvate metabolism" xref: KEGG:map00630 "Glyoxylate and dicarboxylate metabolism" xref: KEGG:map00640 "Propanoate metabolism" xref: KEGG:map00650 "Butanoate metabolism" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map00710 "Carbon fixation in photosynthetic organisms" xref: KEGG:map00720 "Carbon fixation pathways in prokaryotes" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00224 name: tryptophan metabolism namespace: pathway def: "Metabolism of tryptophan amino-acid." [UPa:amorgat] xref: GO:0006568 "biological_process:tryptophan metabolic process" is_a: UPa:UPA00401 ! amino-acid metabolism is_a: UPa:UPA00433 ! aromatic compound metabolism relationship: uniprot_super_pathway UPa:UPA00401 ! amino-acid metabolism [Term] id: UPa:UPA00225 name: lysine degradation namespace: pathway def: "Degradation of lysine amino-acid." [UPa:amorgat] xref: GO:0006554 {source="rdfmatch"} is_a: UPa:UPA00401 ! amino-acid metabolism relationship: uniprot_super_pathway UPa:UPA00401 ! amino-acid metabolism [Term] id: UPa:UPA00226 name: Entner-Doudoroff pathway namespace: pathway def: "Entner-Doudoroff pathway that converts glucose to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it. [GO]." [UPa:amorgat] xref: GO:0009255 "biological_process:Entner-Doudoroff pathway through 6-phosphogluconate" is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00227 name: glyoxylate and dicarboxylate metabolism namespace: pathway def: "Metabolism of glyoxylate and dicarboxylate." [UPa:amorgat] is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00228 name: xylene degradation namespace: pathway def: "Degradation of xylene, a mixture of three aromatic hydrocarbon ortho-, meta- and para-xylene." [UPa:amorgat] xref: GO:0042184 "biological_process:xylene catabolic process" is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00229 name: C21-steroid hormone metabolism namespace: pathway def: "Metabolism of C21-steroid hormone compounds." [UPa:amorgat] xref: GO:0008207 "biological_process:C21-steroid hormone metabolic process" is_a: UPa:UPA00436 ! lipid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00230 name: glycerolipid metabolism namespace: pathway def: "Metabolism of glycerolipids." [UPa:amorgat] xref: GO:0046486 "biological_process:glycerolipid metabolic process" is_a: UPa:UPA00436 ! lipid metabolism is_a: UPa:UPA00615 ! glycerol metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00231 name: pyruvate metabolism namespace: pathway def: "Metabolism of pyruvic acid, the simplest alpha-keto acid that plays an important role in biochemical processes." [UPa:amorgat] synonym: "pyruvic acid metabolism" EXACT [] xref: GO:0006090 "biological_process:pyruvate metabolic process" is_a: UPa:UPA00411 ! carbohydrate metabolism is_a: UPa:UPA00698 ! organic acid metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00232 name: ubiquinone biosynthesis namespace: pathway def: "Biosynthesis of ubiquinones, lipid-soluble electron-transporting coenzymes. Ubiquinones are essential electron carrier in prokaryotes. Ubiquinones are essential molecules in aerobic organisms to achieve both, ATP synthesis and antioxidant defence." [UPa:amorgat] synonym: "coenzyme Q biosynthesis" EXACT [] synonym: "CoQ biosynthesis" EXACT [] xref: GO:0006744 "biological_process:ubiquinone biosynthetic process" xref: PMID:15928598 xref: PMID:16873927 xref: PMID:17033719 is_a: UPa:UPA00975 ! prenylquinone biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00233 name: benzoate degradation via CoA ligation namespace: pathway def: "Degradation of benzoic acid, by its ligation to Coenzyme-A to form benzoyl-CoA." [UPa:amorgat] xref: GO:0010128 "biological_process:benzoate catabolic process via CoA ligation" is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00234 name: enniatin biosynthesis namespace: pathway def: "Biosynthesis of enniatin derivatives. Enniatins are N-methylated cyclohexadepsipeptides produced by various Fusarium species and with manifold biological properties (Tomoda et al. 1992 [PMID:1399840]). They are composed of alternating residues of D-2-hydroxyisovaleric acid (D-Hiv) and an N-methylated branched-chain amino-acid such as L-valine, L-leucine or L-isoleucine. The biosynthesis of enniatins is catalyzed by the multifunctional enzyme enniatin synthetase (Esyn), which belongs to the class of nonribosomal peptide synthetases (NRPSs). Enniatin belong to ionophore antibiotic class." [UPa:amorgat] xref: GO:0046585 "biological_process:enniatin biosynthetic process" xref: PMID:12209259 xref: PMID:1399840 is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00235 name: pyocyanine biosynthesis namespace: pathway def: "Biosynthesis of pyocyanin, a blue pigment produced by bacteria such as Pseudomonas spp. Pyocyanin is a redox-active phenazine compound that kills mammalian and bacterial cells through the generation of reactive oxygen intermediates. Pyocyanin produced by Pseudomonas aeruginosa contributes to its ability to colonise the lungs of cystic fibrosis patients." [UPa:amorgat] synonym: "pyocyanin biosynthesis" EXACT [] is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00464 ! secondary metabolite biosynthesis is_a: UPa:UPA00499 ! pigment biosynthesis relationship: uniprot_super_pathway UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00236 name: 2,4-dichlorobenzoate degradation namespace: pathway def: "Degradation of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs). [GO:0046298]." [UPa:amorgat] xref: GO:0046298 "biological_process:2,4-dichlorobenzoate catabolic process" is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00237 name: beta-glucoside metabolism namespace: pathway def: "Metabolism of beta-glucoside compounds, glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [UPa:amorgat] xref: GO:1901804 {source="rdfmatch"} is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00238 name: sucrose metabolism namespace: pathway def: "Metabolism of sucrose (or saccharose, or 1-alpha-D-glucopyranosyl-2-beta-D-fructofuranoside) is a is a disaccharide (glucose + fructose). In most plants, sucrose is the main product of photosynthesis that is exported from the leaves to fuel growth and synthesis of storage reserves, such as starch and oil, and sucrose itself is often accumulated by plant cells to protect against the effects of dehydration under drought, salinity, or cold stress. Apart from plants, some species of cyanobacteria also synthesize sucrose, often in response to osmotic stress." [UPa:amorgat] synonym: "1-alpha-D-glucopyranosyl-2-beta-D-fructofuranoside metabolism" EXACT [] synonym: "saccharose metabolism" EXACT [] xref: GO:0005985 "biological_process:sucrose metabolic process" is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00484 ! glycan biosynthesis [Term] id: UPa:UPA00239 name: quinoline degradation namespace: pathway def: "Degradation of quinoline, a heterocyclic aromatic organic compound, also known as 1-azanaphthalene, 1-benzazine, or benzo[b]pyridine. Quinoline is an intermediate in metallurgical processes and in dye, polymer, and agrochemical production. It is also a preservative, disinfectant, and solvent." [UPa:amorgat] synonym: "1-azanaphthalene degradation" EXACT [] synonym: "1-benzazine degradation" EXACT [] synonym: "benzo[b]pyridine degradation" EXACT [] is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00240 name: erythromycin biosynthesis namespace: pathway def: "Biosynthesis of erythromycin (also known as eryth ethylsuc), a macrolide antibiotic which has an antimicrobial spectrum similar to or slightly wider than that of penicillin." [UPa:amorgat] synonym: "eryth ethylsuc biosynthesis" EXACT [] xref: GO:1901115 {source="rdfmatch"} is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00241 name: coenzyme A biosynthesis namespace: pathway def: "Biosynthesis of coenzyme A (CoA), notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. Coenzyme A is synthesized in a five-step process from pantothenate." [UPa:amorgat] synonym: "CoA biosynthesis" EXACT [] xref: GO:0015937 "biological_process:coenzyme A biosynthetic process" xref: KEGG:map00770 "Pantothenate and CoA biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:COA-PWY is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00242 name: hexose metabolism namespace: pathway def: "Metabolism of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [UPa:amorgat] xref: GO:0019318 "biological_process:hexose metabolic process" is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00244 name: pyridoxine 5'-phosphate biosynthesis namespace: pathway def: "Biosynthesis of pyridoxine 5'-phosphate, one of the de novo biosynthesis pathway. In E. coli, this pathway requires PLP as cofactor in its own synthesis." [UPa:amorgat] synonym: "de novo vitamin B6 biosynthesis (glutamate pathway)" EXACT [] synonym: "de novo vitamin B6 biosynthesis (PdxA/PdxJ pathway)" EXACT [] synonym: "PNP biosynthesis" EXACT [] xref: KEGG:map00750 "Vitamin B6 metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00245 name: pyridoxal 5'-phosphate biosynthesis namespace: pathway def: "Biosynthesis of pyridoxal 5'-phosphate. This pathway corresponds to one of the de novo biosynthesis pathway. The biosynthesis of PLP is performed by a complex reaction: in addition to ammonia transfer PdxS/PdxT catalyzes condensation of two phosphosugars, closure of the pyridine ring, as well as isomerase reactions for its phosphosugar substrates. The complexity of the enzyme correlates well with the strong conservation of the PdxS sequence. Contrary to the alternative PLP biosynthesis pathway (glutamate pathway), this pathway does not require PLP as cofactor in its own synthesis." [UPa:amorgat] synonym: "de novo vitamin B6 biosynthesis (glutamine pathway)" EXACT [] synonym: "de novo vitamin B6 biosynthesis (PdxS/PdxT pathway)" EXACT [] synonym: "de novo vitaminB6 biosynthesis (PDX1/PDX2 pathway)" EXACT [] synonym: "PLP biosynthesis" EXACT [] xref: GO:0042823 "biological_process:pyridoxal phosphate biosynthetic process" is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00246 name: pentose and glucuronate interconversion namespace: pathway def: "Pentose and glucuronate interconversion pathway." [UPa:amorgat] is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00247 name: 4-aminobutanoate biosynthesis namespace: pathway def: "Biosynthesis of 4-aminobutanoate (GABA)." [UPa:amorgat] synonym: "4-aminobutyrate biosynthesis" EXACT [] synonym: "GABA biosynthesis" EXACT [] synonym: "gamma-aminobutyrate biosynthesis" EXACT [] xref: GO:0009449 "biological_process:gamma-aminobutyric acid biosynthetic process" is_a: UPa:UPA00289 ! amine and polyamine biosynthesis is_a: UPa:UPA00732 ! 4-aminobutanoate metabolism relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00248 name: spermidine biosynthesis namespace: pathway def: "Biosynthesis of spermidine by the addition of a propylamine moiety to putrescine." [UPa:amorgat] synonym: "N-(3-aminopropyl)-1,4-butane-diamine biosynthesis" EXACT [] xref: GO:0008295 "biological_process:spermidine biosynthetic process" xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map00480 "Glutathione metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:BSUBPOLYAMSYN-PWY is_a: UPa:UPA00289 ! amine and polyamine biosynthesis is_a: UPa:UPA00457 ! putrescine metabolism relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00249 name: spermine biosynthesis namespace: pathway def: "Biosynthesis of spermine by the addition of a propylamine moiety to spermidine." [UPa:amorgat] synonym: "N,N'-bis(3-aminopropyl)-1,4-butanediamine biosynthesis" EXACT [] xref: GO:0006597 "biological_process:spermine biosynthetic process" xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map00410 "beta-Alanine metabolism" xref: KEGG:map00480 "Glutathione metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:ARGSPECAT-PWY xref: PMID:15459188 is_a: UPa:UPA00289 ! amine and polyamine biosynthesis is_a: UPa:UPA00826 ! spermine metabolism relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00250 name: spermidine degradation namespace: pathway def: "Degradation of permidine polyamine." [UPa:amorgat] synonym: "N-(3-aminopropyl)-1,4-butane-diamine degradation" EXACT [] xref: GO:0046203 "biological_process:spermidine catabolic process" xref: KEGG:map00330 "Arginine and proline metabolism" xref: PMID:16849793 is_a: UPa:UPA00456 ! amine and polyamine degradation is_a: UPa:UPA00826 ! spermine metabolism relationship: uniprot_super_pathway UPa:UPA00456 ! amine and polyamine degradation [Term] id: UPa:UPA00251 name: protoporphyrin-IX biosynthesis namespace: pathway def: "Biosynthesis of protoporphyrin-IX, a porphyrin derivative precursor of heme and chlorphyll compounds." [UPa:amorgat] xref: GO:0006782 "biological_process:protoporphyrinogen IX biosynthetic process" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00860 "Porphyrin and chlorophyll metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00678 ! porphyrin-containing compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00677 ! porphyrin-containing compound metabolism [Term] id: UPa:UPA00252 name: protoheme biosynthesis namespace: pathway def: "Biosynthesis of proteoheme (heme B) from protoporphyrin IX." [UPa:amorgat] synonym: "haem B biosynthesis" EXACT [] synonym: "heme B biosynthesis" EXACT [] synonym: "protoheme IX biosynthesis" EXACT [] xref: KEGG:map00860 "Porphyrin and chlorophyll metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00678 ! porphyrin-containing compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00677 ! porphyrin-containing compound metabolism [Term] id: UPa:UPA00253 name: NAD(+) biosynthesis namespace: pathway def: "Biosynthesis of NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in all living cells. NAD+ is a dinucleotide, since it consists of two nucleotides joined through their phosphate groups: with one nucleotide containing an adenosine ring, and the other containing nicotinamide." [UPa:amorgat] synonym: "nicotinamide adenine dinucleotide biosynthesis" EXACT [] xref: GO:0009435 "biological_process:NAD biosynthetic process" xref: KEGG:map00380 "Tryptophan metabolism" xref: KEGG:map00760 "Nicotinate and nicotinamide metabolism" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:12496312 xref: PMID:14592712 xref: PMID:16698895 is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00254 name: L-arginine degradation via ADI pathway namespace: pathway def: "Degradation of L-arginine via ADI (arginine deiminase) pathway. In this pathway, L-arginine is converted into ornithine and carbamoyl-phosphate. Carbamoyl-phosphate is further converted into ammonia and CO2 with the concomitant production of ATP. This last part is described as an independant pathway." [UPa:amorgat] synonym: "arginine deiminase (ADI) pathway" EXACT [] xref: GO:0019547 "biological_process:arginine catabolic process to ornithine" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:12399499 xref: PMID:12406748 xref: PMID:15006749 xref: PMID:16385025 is_a: UPa:UPA00073 ! L-arginine degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00255 name: stachydrine degradation namespace: pathway def: "Degradation of stachydrine, the betaine derivative of proline." [UPa:amorgat] synonym: "N-methylproline methylbetaine degradation" EXACT [] xref: GO:0019504 "biological_process:stachydrine catabolic process" xref: PMID:9758825 is_a: UPa:UPA00456 ! amine and polyamine degradation relationship: uniprot_super_pathway UPa:UPA00456 ! amine and polyamine degradation [Term] id: UPa:UPA00256 name: triacylglycerol degradation namespace: pathway def: "Degradation of triacylglycerol (triacylglyceride, triglyceride, TAG). Triacylglycerol is a glyceride in which the glycerol is esterified with three fatty acids. It is the main constituent of vegetable oil and animal fats." [UPa:amorgat] synonym: "TAG degradation" EXACT [] synonym: "triacylglyceride degradation" EXACT [] synonym: "triglyceride degradation" EXACT [] synonym: "triglyceride lipolysis" EXACT [] xref: GO:0019433 "biological_process:triglyceride catabolic process" is_a: UPa:UPA00494 ! glycerolipid degradation relationship: uniprot_super_pathway UPa:UPA00230 ! glycerolipid metabolism [Term] id: UPa:UPA00257 name: (R)-mevalonate degradation namespace: pathway def: "Degradation of mevalonic acid, a key metabolic intermediate." [UPa:amorgat] synonym: "mevalonate degradation" EXACT [] xref: KEGG:map00900 "Terpenoid backbone biosynthesis" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00497 ! (R)-mevalonate metabolism is_a: UPa:UPA00498 ! metabolic intermediate degradation relationship: uniprot_super_pathway UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00258 name: urea degradation namespace: pathway def: "Degradation of urea." [UPa:amorgat] xref: GO:0043419 "biological_process:urea catabolic process" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map00791 "Atrazine degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00045 ! nitrogen metabolism relationship: uniprot_super_pathway UPa:UPA00045 ! nitrogen metabolism [Term] id: UPa:UPA00259 name: geranyl diphosphate biosynthesis namespace: pathway def: "Biosynthesis of geranyl-PP (geranyl diphosphate)." [UPa:amorgat] synonym: "geranyl pyrophosphate biosynthesis" EXACT [] synonym: "geranyl-PP biosynthesis" EXACT [] xref: GO:0033384 "biological_process:geranyl diphosphate biosynthetic process" xref: KEGG:map00900 "Terpenoid backbone biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00416 ! isoprenoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00416 ! isoprenoid biosynthesis [Term] id: UPa:UPA00260 name: farnesyl diphosphate biosynthesis namespace: pathway def: "Biosynthesis of farnesyl-PP (farnesyl diphosphate)." [UPa:amorgat] synonym: "farnesyl pyrophosphate biosynthesis" EXACT [] synonym: "trans,trans-farnesyl diphosphate biosynthesis" EXACT [] xref: GO:0045337 "biological_process:farnesyl diphosphate biosynthetic process" xref: KEGG:map00900 "Terpenoid backbone biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00416 ! isoprenoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00416 ! isoprenoid biosynthesis [Term] id: UPa:UPA00261 name: L-proline degradation into L-glutamate namespace: pathway def: "Degradation of L-proline into L-glutamic acid throught two-step oxidation of proline. Enteric bacteria possess a multifunctional flavoprotein, called proline utilization A (PutA), that acts as both a membrane-associated proline catabolic enzyme and a transcriptional repressor of proline utilization (put) genes." [UPa:amorgat] xref: GO:0010133 "biological_process:proline catabolic process to glutamate" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:12514740 xref: PMID:17001030 is_a: UPa:UPA00532 ! L-proline degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00262 name: siroheme biosynthesis namespace: pathway def: "Biosynthesis of siroheme, the cofactor for sulfite and nitrite reductases. Siroheme is formed by methylation, oxidation, and iron insertion into the tetrapyrrole uroporphyrinogen III (Uro-III)." [UPa:amorgat] synonym: "sirohaem biosynthesis" EXACT [] xref: GO:0019354 "biological_process:siroheme biosynthetic process" xref: KEGG:map00860 "Porphyrin and chlorophyll metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:11114933 xref: PMID:12408752 xref: PMID:14595395 is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00678 ! porphyrin-containing compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00677 ! porphyrin-containing compound metabolism [Term] id: UPa:UPA00263 name: L-ascorbate degradation namespace: pathway def: "Degradation of L-ascorbic acid (vitamin C). The three gene ulaABC (formerly known as sgaTBA) encode the three components of the L-ascorbate phosphotransferase transport system (UlaABC). They are involved in the uptake and phosphorylation of L-ascorbate [PMID:12644495. Intracellular L-ascorbate-6-P is then transformed by L-ascorbate-6-P lactonase into 3-keto-L-gulonate-6-P. It has been proposed that this compound is decarboxylated by UlaD to L-xylulose-5-P, which is then converted to D-xylulose-5-P by the sequential actions of UlaE (encoding 3-epimerase activity) and UlaF (encoding 4-epimerase activity)." [UPa:amorgat] synonym: "L-ascorbic acid degradation" EXACT [] synonym: "vitamin C degradation" EXACT [] xref: GO:0019854 "biological_process:L-ascorbic acid catabolic process" xref: KEGG:map00040 "Pentose and glucuronate interconversions" xref: KEGG:map00053 "Ascorbate and aldarate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:12644495 xref: PMID:14996803 is_a: UPa:UPA00413 ! carbohydrate degradation is_a: UPa:UPA00483 ! cofactor degradation relationship: uniprot_super_pathway UPa:UPA00483 ! cofactor degradation [Term] id: UPa:UPA00264 name: betaine biosynthesis namespace: pathway def: "Biosynthesis of glycine betaine (N,N,N-trimethylglycine), an important osmoprotectant. Glycine betaine is synthesized in response to abiotic stresses. Although almost all known biosynthetic pathways of betaine are oxidation of choline, an alternative pathway converts glycine to betaine through glycine methylation." [UPa:amorgat] synonym: "glycine betaine biosynthesis" EXACT [] synonym: "N,N,N-trimethylglycine biosynthesis" EXACT [] synonym: "trimethylaminoacetate biosynthesis" EXACT [] xref: GO:0031456 "biological_process:glycine betaine biosynthetic process" xref: PMID:11330717 is_a: UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00265 name: 1,2-dichloroethane degradation namespace: pathway def: "Degradation of 1,2-dichloroethane (1,2-DCA). The greatest use of 1,2-dichloroethane is in making chemicals involved in plastics, rubber and synthetic textile fibers. Other uses include: as a solvent for resins and fats, photography, photocopying, cosmetics, drugs; and as a fumigant for grains and orchards. It is possibly carcinogenic to humans (Group 2B)." [UPa:amorgat] synonym: "1,2-DCA degradation" EXACT [] xref: GO:0019260 "biological_process:1,2-dichloroethane catabolic process" xref: KEGG:map00361 "Chlorocyclohexane and chlorobenzene degradation" xref: KEGG:map00625 "Chloroalkane and chloroalkene degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:12DICHLORETHDEG-PWY is_a: UPa:UPA00007 ! haloalkane degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00266 name: iron-sulfur cluster biosynthesis namespace: pathway def: "Biosynthesis of iron-sulfur [Fe-S] cluster. Iron-sulfur [Fe-S] clusters are ubiquitous and evolutionary ancient prosthetic groups that are required to sustain fundamental life processes. Owing to their remarkable structural plasticity and versatile chemical/electronic features [Fe-S] clusters participate in electron transfer, substrate binding/activation, iron/sulfur storage, regulation of gene expression, and enzyme activity. Formation of intracellular [Fe-S] clusters does not occur spontaneously but requires a complex biosynthetic machinery. Three different types of [Fe-S] cluster biosynthetic systems have been discovered, and all of them are mechanistically unified by the requirement for a cysteine desulfurase and the participation of an [Fe-S] cluster scaffolding protein. [PMID:15952888]." [UPa:amorgat] xref: GO:0016226 {source="rdfmatch"} xref: PMID:15952888 is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00267 name: trichothecene biosynthesis namespace: pathway def: "Biosynthesis of trichothecenes, a group of sesquiterpenes produced by various Fusarium species like F. graminearum, F. sporotrichioides, F. poae or F. equiseti." [UPa:amorgat] is_a: UPa:UPA00449 ! sesquiterpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00449 ! sesquiterpene biosynthesis [Term] id: UPa:UPA00268 name: bluish-green pigment biosynthesis namespace: pathway def: "Biosynthesis of bluish-green pigment. Bluish-green pigment is produced by Aspergillus fumigatus, a filamentous fungus (an important opportunistic pathogen that primarily affects immunocompromised patients). Conidial pigmentation of A. fumigatus significantly influences its virulence in a murine model." [UPa:amorgat] xref: PMID:10515939 xref: PMID:9383199 is_a: UPa:UPA00499 ! pigment biosynthesis relationship: uniprot_super_pathway UPa:UPA00499 ! pigment biosynthesis [Term] id: UPa:UPA00269 name: heme A biosynthesis namespace: pathway def: "Biosynthesis of heme A, a prosthetic group in many respiratory oxidases. It is synthesised from heme B (protoheme IX) with heme O as an intermediate. In Bacillus subtilis two genes required for heme A synthesis, ctaA and ctaB, have been identified. CtaB is the heme O synthase and CtaA is involved in the conversion of heme O to heme A. The model described by Brown et al. [PMID:10675592] is that Heme O Synthase (HOS) and Heme A Synthase (HAS) form a complex and that heme O is transferred directly from HOS to HAS. The biochemical reactions are not yet clearly defined." [UPa:amorgat] xref: GO:0006784 "biological_process:heme a biosynthetic process" xref: KEGG:map00860 "Porphyrin and chlorophyll metabolism" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:10675592 xref: PMID:15491161 xref: PMID:16156667 xref: PMID:16321940 is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00678 ! porphyrin-containing compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00677 ! porphyrin-containing compound metabolism [Term] id: UPa:UPA00270 name: quinolate metabolism namespace: pathway def: "metabolism of quinolinate (quinolinic acid), a potent endogenous excitotoxin of neuronal cells. Elevation of quinolinate levels in the brain has been implicated in the pathogenesis of various neurodegenerative disorders, the so-called 'quinolinate hypothesis.' Quinolinate is non- enzymatically derived from alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS). ACMS decarboxylase (ACMSD) is the only known enzyme that can process ACMS to a begnin catabolite and thus prevent the accumulation of quinolinate from ACMS. ACMSD seems to be regulated by nutritional and hormonal signals, but its molecular mechanism has, to date, been largely unknown. [PMID:12140278]." [UPa:amorgat] synonym: "quinolinic acid metabolism" EXACT [] xref: PMID:12140278 xref: PMID:15206762 xref: PMID:17288562 is_a: UPa:UPA00465 ! secondary metabolite metabolism relationship: uniprot_super_pathway UPa:UPA00465 ! secondary metabolite metabolism [Term] id: UPa:UPA00271 name: ommochrome biosynthesis namespace: pathway def: "Biosynthesis of ommochrome (brown eye pigment). Ommochrome (or visual pigment) refers to several biological pigments that occur in the eyes of crustaceans and insects. The eye color is determined by the ommochromes. Ommochromes are also found in the chromatophores of cephalopods, and in spiders. Ommochromes are metabolites of tryptophan, via kynurenine and 3-hydroxykynurenine. They are responsible for a wide variety of colors, ranging from yellow over red and brown to black. Lighter colors tend to be generated by ommatins, while mixtures of ommatin and ommins are responsible for darker colors." [UPa:amorgat] synonym: "brown eye pigment" EXACT [] xref: GO:0006727 "biological_process:ommochrome biosynthetic process" is_a: UPa:UPA00499 ! pigment biosynthesis relationship: uniprot_super_pathway UPa:UPA00499 ! pigment biosynthesis [Term] id: UPa:UPA00272 name: benzene degradation namespace: pathway def: "Oxidation of benzene to catechol via cis-benzene glycol (cis-1,2 -dihydroxy-cyclohexa-3,5-diene, cis-1,2-dihydrobenzene-1,2-diol). The conversion of benzene to catechol is performed in two steps catalyzed by benzene dioxygenase and cis-benzene glycol dehydrogenase. Benzene dioxygenase, catalyzing the oxidation of benzene to cis-benzene glycol, is a multicomponent enzyme system." [UPa:amorgat] xref: KEGG:map00361 "Chlorocyclohexane and chlorobenzene degradation" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:3667527 xref: PMID:8344526 is_a: UPa:UPA00433 ! aromatic compound metabolism relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00273 name: toluene degradation namespace: pathway def: "Oxidation of toluene to 3-methylcatechol via toluene-cis dihydrodiol." [UPa:amorgat] synonym: "methylbenzene degradation" EXACT [] xref: GO:0042203 "biological_process:toluene catabolic process" xref: KEGG:map00623 "Toluene degradation" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00433 ! aromatic compound metabolism relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00274 name: creatinine degradation namespace: pathway def: "Degradation of creatinine (1-methylglycocyamidine). Creatinine is a readily available nitrogen source found in the faeces of different animals, including earthworms and birds. A number of bacteria utilizing this compound as carbon and/or nitrogen source has already been described for example, Alcaligenes, Arthrobacter, Corynebacterium, Flavobacterium, and Pseudomonas species." [UPa:amorgat] synonym: "1-methylglycocyamidine degradation" EXACT [] xref: GO:0006602 "biological_process:creatinine catabolic process" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:10893433 xref: PMID:1381445 xref: PMID:15148566 is_a: UPa:UPA00456 ! amine and polyamine degradation relationship: uniprot_super_pathway UPa:UPA00456 ! amine and polyamine degradation [Term] id: UPa:UPA00275 name: riboflavin biosynthesis namespace: pathway def: "Biosynthesis of riboflavin (vitamin B2), the universal precursor of flavocoenzymes. It is biosynthesized by plants and many microorganisms but must be obtained from dietary sources by animals." [UPa:amorgat] synonym: "E101 biosynthesis" EXACT [] synonym: "vitamin B2 biosynthesis" EXACT [] synonym: "vitamin G biosynthesis" EXACT [] xref: GO:0009231 "biological_process:riboflavin biosynthetic process" xref: KEGG:map00740 "Riboflavin metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:11153262 xref: PMID:16010344 xref: PMID:16607521 xref: PMID:16923880 is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00276 name: FMN biosynthesis namespace: pathway def: "Biosynthesis of FMN (riboflavin-5-phosphate) cofactor." [UPa:amorgat] synonym: "flavin mononucleotide biosynthesis" EXACT [] synonym: "riboflavin-5-phosphate biosynthesis" EXACT [] xref: GO:0009398 "biological_process:FMN biosynthetic process" xref: KEGG:map00740 "Riboflavin metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:RIBOSYN2-PWY is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00277 name: FAD biosynthesis namespace: pathway def: "Biosynthesis of FAD (flavin adenine dinucleotide)." [UPa:amorgat] synonym: "flavin adenine dinucleotide biosynthesis" EXACT [] xref: GO:0006747 "biological_process:FAD biosynthetic process" xref: KEGG:map00740 "Riboflavin metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00278 name: betalain biosynthesis namespace: pathway def: "Biosynthesis of batalains, a class of red and yellow indole-derived pigments found in plants." [UPa:amorgat] is_a: UPa:UPA00499 ! pigment biosynthesis relationship: uniprot_super_pathway UPa:UPA00499 ! pigment biosynthesis [Term] id: UPa:UPA00279 name: bile acid degradation namespace: pathway def: "Degradation of bile acids, any of a group of steroid carboxylic acids occurring in bile [GO]." [UPa:amorgat] xref: GO:0030573 "biological_process:bile acid catabolic process" is_a: UPa:UPA00436 ! lipid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00280 name: N-glycan degradation namespace: pathway def: "Degradation of asparagine (N)-linked oligosaccharides (N-glycans)." [UPa:amorgat] synonym: "N-linked oligosaccharide degradation" EXACT [] is_a: UPa:UPA00442 ! glycan degradation is_a: UPa:UPA00957 ! N-glycan metabolism relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00281 name: LPS O-antigen biosynthesis namespace: pathway def: "Biosynthesis of O-antigen, the polysaccharide side chain of lipopolysaccharide (LPS) molecules. The composition of the O side chain varies between different gram-negative bacterial strains. O side chains are easily recognized by the antibodies of the host, however, the nature of the chain can easily be modified by Gram-negative bacteria to avoid detection." [UPa:amorgat] synonym: "lipopolysaccharide O-antigen biosynthesis" EXACT [] xref: GO:0009243 "biological_process:O antigen biosynthetic process" is_a: UPa:UPA00030 ! lipopolysaccharide biosynthesis is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00324 ! bacterial outer membrane biogenesis [Term] id: UPa:UPA00282 name: triacylglycerol biosynthesis namespace: pathway def: "Biosynthesis of triacylglycerol (triacylglyceride, triglyceride, TAG). Triacylglycerol is glyceride in which the glycerol is esterified with three fatty acids. It is the main constituent of vegetable oil and animal fats." [UPa:amorgat] synonym: "TAG biosyntheis" EXACT [] synonym: "triacylglyceride biosynthesis" EXACT [] synonym: "triglyceride biosynthesis" EXACT [] xref: GO:0019432 "biological_process:triglyceride biosynthetic process" is_a: UPa:UPA00495 ! glycerolipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00230 ! glycerolipid metabolism [Term] id: UPa:UPA00283 name: germacradienol biosynthesis namespace: pathway def: "Biosynthesis of the sesquiterponoid germacradienol ((1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol)." [UPa:amorgat] synonym: "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol biosynthesis" EXACT [] xref: KEGG:map00909 "Sesquiterpenoid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00449 ! sesquiterpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00449 ! sesquiterpene biosynthesis [Term] id: UPa:UPA00284 name: LOS oligosaccharide biosynthesis namespace: pathway def: "Biosynthesis of the oligosaccharide component of lipooligosaccharide (LOS)." [UPa:amorgat] is_a: UPa:UPA00484 ! glycan biosynthesis is_a: UPa:UPA00501 ! lipooligosaccharide biosynthesis relationship: uniprot_super_pathway UPa:UPA00324 ! bacterial outer membrane biogenesis [Term] id: UPa:UPA00285 name: germacrene D biosynthesis namespace: pathway def: "Biosynthesis of the sesquiterponoid germacrene D." [UPa:amorgat] xref: KEGG:map00909 "Sesquiterpenoid biosynthesis" is_a: UPa:UPA00449 ! sesquiterpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00449 ! sesquiterpene biosynthesis [Term] id: UPa:UPA00286 name: alginate biosynthesis namespace: pathway def: "Biosynthesis of alginate, an hydrophilic exopolysaccharide produced by brown seaweeds an some bacteria. There is a strong correlation of alginate production with patients suffering from the disease cystic fibrosis caused by some pathogen bacteria (Pseudomonas, Azopbacter). Chemically, alginate is a linear copolymer with homopolymeric blocks of (1-4)-linked beta-D-mannuronate (M) and its C-5 epimer alpha-L-guluronate (G) residues, respectively, covalently linked together in different sequences." [UPa:amorgat] synonym: "alginic acid biosynthesis" EXACT [] xref: GO:0042121 "biological_process:alginic acid biosynthetic process" is_a: UPa:UPA00484 ! glycan biosynthesis is_a: UPa:UPA00502 ! alginate metabolism relationship: uniprot_super_pathway UPa:UPA00484 ! glycan biosynthesis [Term] id: UPa:UPA00287 name: aflatoxin biosynthesis namespace: pathway def: "Biosynthesis of aflatoxin, a family of acutely toxic, teratogenic, potent carcinogenic, and mutagenic metabolites produced by certain strains of common molds Aspergillus flavus and A. parasiticus." [UPa:amorgat] xref: GO:0045122 "biological_process:aflatoxin biosynthetic process" xref: PMID:15006741 xref: PMID:15022028 xref: PMID:16349476 xref: PMID:19537208 is_a: UPa:UPA00473 ! polyketide biosynthesis is_a: UPa:UPA00478 ! mycotoxin biosynthesis relationship: uniprot_super_pathway UPa:UPA00478 ! mycotoxin biosynthesis [Term] id: UPa:UPA00288 name: glycine biosynthesis namespace: pathway def: "Biosynthesis of glycine amino-acid." [UPa:amorgat] xref: GO:0006545 "biological_process:glycine biosynthetic process" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00460 "Cyanoamino acid metabolism" xref: KEGG:map00670 "One carbon pool by folate" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00289 name: amine and polyamine biosynthesis namespace: pathway def: "Biosynthesis of amines and polyamines. These compounds play a variety of roles in metabolism, including acting as osmoprotectants, keeping DNA in a condensed state, and serving as intermediates in the synthesis of macromolecules. The polyamines, e.g. 1,3-diaminopropane, putrescine, cadaverine, agmatine, spermidine and spermine, are wide-spread in all organisms, and have been shown to play a role in the regulation of growth and differentiation of virtually all types of cells." [UPa:amorgat] xref: GO:0006596 "biological_process:polyamine biosynthetic process" xref: GO:0009309 "biological_process:amine biosynthetic process" xref: PMID:3157043 is_a: UPa:UPA00455 ! amine and polyamine metabolism [Term] id: UPa:UPA00290 name: choline biosynthesis namespace: pathway def: "Biosynthesis of choline." [UPa:amorgat] synonym: "bilineurine biosynthesis" EXACT [] xref: GO:0042425 "biological_process:choline biosynthetic process" is_a: UPa:UPA00289 ! amine and polyamine biosynthesis is_a: UPa:UPA00503 ! choline metabolism relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00291 name: betaine degradation namespace: pathway def: "Degradation of betaine (trimethylaminoacetate, N,N,N-trimethylglycine)." [UPa:amorgat] synonym: "glycine betaine degradation" EXACT [] synonym: "N,N,N-trimethylglycine degradation" EXACT [] synonym: "trimethylaminoacetate degradation" EXACT [] xref: GO:0006579 "biological_process:amino-acid betaine catabolic process" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00456 ! amine and polyamine degradation is_a: UPa:UPA00503 ! choline metabolism relationship: uniprot_super_pathway UPa:UPA00456 ! amine and polyamine degradation [Term] id: UPa:UPA00292 name: sarcosine degradation namespace: pathway def: "Degradation of sarcosine." [UPa:amorgat] synonym: "N-methylglycine degradation" EXACT [] xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00456 ! amine and polyamine degradation relationship: uniprot_super_pathway UPa:UPA00456 ! amine and polyamine degradation [Term] id: UPa:UPA00293 name: D-ribose 5-phosphate biosynthesis namespace: pathway def: "Ribose-5-phosphate is generally assumed to arise via the oxidative and nonoxidative pentose phosphate pathways. In some archaea, ribulose monophosphate (RuMP) pathway may be functioning as an alternate route to ribose-5-phosphate. Grochowski et al [PMID: 16237021] showed experimentally that that in M. jannaschii, ribose-5-phosphate is produced exclusively via the RuMP pathway and that these cells do not appear to operate a pentose phosphate pathway." [UPa:amorgat] xref: GO:1901280 {source="rdfmatch"} xref: PMID:10648518 xref: PMID:16237021 is_a: UPa:UPA00412 ! carbohydrate biosynthesis relationship: uniprot_super_pathway UPa:UPA00412 ! carbohydrate biosynthesis [Term] id: UPa:UPA00294 name: formaldehyde assimilation via RuMP pathway namespace: pathway def: "Formaldehyde is the key intermediate in C1 metabolism and can be assimilated via the ribulose monophosphate (RuMP) pathway. The ribulose monophosphate (RuMP) pathway, involving 3-hexulose-6-phosphate synthase (HPS) and 6-phospho-3-hexuloisomerase (PHI), is now recognized as a widespread prokaryotic pathway for formaldehyde fixation and detoxification. The RuMP pathways consists of three main parts: i) fixation, ii) cleavage and iii) rearrangement. i) Fixation stage: formaldehyde and ribulose-5-phosphate (RuMP) are condensed to form hexulose-6-phosphate (HuMP), which in turn is converted to fructose-6-phosphate (FMP) by hexulosephosphate isomerase (HPI). By the assimilation of three formaldehyde molecules, three molecules of FMP are created." [UPa:amorgat] synonym: "formaldehyde assimilation via ribulose monophosphate cycle" EXACT [] synonym: "ribulose monophosphate pathway" EXACT [] synonym: "RuMP cycle" EXACT [] xref: GO:0019647 "biological_process:formaldehyde assimilation via ribulose monophosphate cycle" xref: KEGG:map00040 "Pentose and glucuronate interconversions" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:16788179 is_a: UPa:UPA00411 ! carbohydrate metabolism is_a: UPa:UPA00445 ! one-carbon metabolism relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00295 name: antibiotic biosynthesis namespace: pathway def: "Biosynthesis of organic compounds able to kill bacteria, or inhibit their growth." [UPa:amorgat] xref: GO:0017000 "biological_process:antibiotic biosynthetic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00296 name: cholesterol metabolism namespace: pathway def: "Metabolism of cholesterol." [UPa:amorgat] xref: GO:0008203 "biological_process:cholesterol metabolic process" is_a: UPa:UPA00504 ! steroid metabolism relationship: uniprot_super_pathway UPa:UPA00504 ! steroid metabolism [Term] id: UPa:UPA00297 name: dicyanocobinamide salvage pathway namespace: pathway def: "Dicyanocobinamide is a coenzyme B<sub>12</sub> precursor. Regarding Woodson ate al [PMID:14990804] prokaryotes have evolved at least two distinct pathways for salvaging the precursor cobinamide (Cbi) from the environment. Both pathways accomplish the same goal, which is to convert AdoCbi (adenosylcobinamide) to AdoCbi-P, a true intermediate of the de novo biosynthetic pathway." [UPa:amorgat] synonym: "Cbi salvage pathway" EXACT [] synonym: "cobinamide salvage pathway" EXACT [] xref: PMID:14990804 is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00298 name: siderophore metabolism namespace: pathway def: "The chemical reactions and physical changes involving siderophore (siderochromes), low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderochromes have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [UPa:amorgat] synonym: "siderochrome metabolism" EXACT [] xref: GO:0009237 "biological_process:siderophore metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00299 name: trehalose biosynthesis namespace: pathway def: "Biosynthesis of trehalose, also known as mycose, a disaccharide found extensively but not abundantly in nature. It can be synthesised by fungi, plants and invertebrate animals. It is implicated in anhydrobiosis - the ability of plants and animals to withstand prolonged periods of desiccation." [UPa:amorgat] xref: GO:0005992 "biological_process:trehalose biosynthetic process" is_a: UPa:UPA00443 ! trehalose metabolism is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00484 ! glycan biosynthesis [Term] id: UPa:UPA00300 name: trehalose degradation namespace: pathway def: "Degradation of trehalose, also known as mycose, a disaccharide found extensively but not abundantly in nature. Trehalose is metabolized by a number of bacteria, including Streptococcus mutans, the common oral bacteria responsible for oral plaque. The enzyme trehalase, a glycoside hydrolase, present but not abundant in most people, breaks trehalose into two glucose molecules, which can then be readily absorbed in the gut." [UPa:amorgat] xref: GO:0005993 "biological_process:trehalose catabolic process" xref: KEGG:map00500 "Starch and sucrose metabolism" xref: MetaCyc:PWY0-1182 is_a: UPa:UPA00442 ! glycan degradation is_a: UPa:UPA00443 ! trehalose metabolism relationship: uniprot_super_pathway UPa:UPA00442 ! glycan degradation [Term] id: UPa:UPA00301 name: LPS oligosaccharide biosynthesis namespace: pathway def: "Biosynthesis of inner core oligosaccharide, a component of lipopolysaccharide (LPS) molecules. Core oligosaccharide contains unusual sugars (e.g. KDO, keto-deoxyoctulonate and heptulose). It contains two glucosamine sugar derivatives each containing three fatty acids with phosphate or pyrophosphate attached. The core polysaccharide is attached to lipid A, which is also in part responsible for the toxicity of gram-negative bacteria." [UPa:amorgat] synonym: "LPS inner core oligosaccharide biosynthesis" EXACT [] xref: PMID:11371519 is_a: UPa:UPA00030 ! lipopolysaccharide biosynthesis is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00030 ! lipopolysaccharide biosynthesis [Term] id: UPa:UPA00302 name: siderophore biosynthesis namespace: pathway def: "Biosynthesis of iron-sequestering compounds. The production of siderophores is a key feature which enables pathogenic bacteria to survive within the vertebrate host. Siderophores facilitate the solubilization and transport of ferric iron into the cell essential requirement for bacterial growth." [UPa:amorgat] synonym: "siderochrome biosynthesis" EXACT [] xref: GO:0019290 "biological_process:siderophore biosynthetic process" is_a: UPa:UPA00298 ! siderophore metabolism [Term] id: UPa:UPA00303 name: atropine degradation namespace: pathway def: "Degradation of atropine, a tropan alkaloid." [UPa:amorgat] synonym: "DL-hyoscyamine degradation" EXACT [] xref: GO:1901050 {source="rdfmatch"} xref: PMID:16736160 is_a: UPa:UPA00508 ! tropane alkaloid degradation relationship: uniprot_super_pathway UPa:UPA00447 ! alkaloid degradation [Term] id: UPa:UPA00304 name: nucleotide-sugar biosynthesis namespace: pathway def: "Biosynthesis of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [source: GO]." [UPa:amorgat] xref: GO:0009226 "biological_process:nucleotide-sugar biosynthetic process" is_a: UPa:UPA00215 ! nucleotide-sugar metabolism [Term] id: UPa:UPA00305 name: alkene biosynthesis namespace: pathway def: "Biosynthesis of alkene, unsaturated chemical compound containing at least one carbon-to-carbon double bond." [UPa:amorgat] synonym: "olefin biosynthesis" EXACT [] xref: GO:0043450 "biological_process:alkene biosynthetic process" is_a: UPa:UPA00347 ! hydrocarbon biosynthesis is_a: UPa:UPA00777 ! alkene metabolism [Term] id: UPa:UPA00306 name: (S)-reticuline biosynthesis namespace: pathway def: "Biosynthesis of (S)-reticuline, an important intermediate in synthesizing isoquinoline alkaloids. Reticuline is an important intermediate in the production of analgesic morphinan alkaloids (e.g. morphine), antimicrobial berberine alkaloids (e.g. berberine), and antimicrobial benzophenanthridine alkaloids (e.g. sanguinarine)." [UPa:amorgat] xref: KEGG:map00950 "Isoquinoline alkaloid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:10811648 is_a: UPa:UPA00510 ! isoquinoline alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00307 name: palmatine biosynthesis namespace: pathway def: "Biosynthesis of palmatine, an isoquinoline alkaloid." [UPa:amorgat] xref: KEGG:map00950 "Isoquinoline alkaloid biosynthesis" xref: PMID:12423366 is_a: UPa:UPA00510 ! isoquinoline alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00308 name: berbamunine biosynthesis namespace: pathway def: "Biosynthesis of berbamunine, an isoquinoline alkaloid." [UPa:amorgat] xref: GO:0035833 "biological_process:berbamunine biosynthetic process" xref: KEGG:map00950 "Isoquinoline alkaloid biosynthesis" xref: PMID:12423366 is_a: UPa:UPA00510 ! isoquinoline alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00309 name: violacein biosynthesis namespace: pathway def: "Biosynthesis of violacein, a deep violet pigment produced by Chromobacterium violaceum. The low solubility of violacein in water and the high molar extinction coefficient in methanol lead Antonio and Creczynski-Pasa [PMID:15100990] to suppose that it is involved in protection against visible radiation, since C.violaceum bacterium is widely found in the water and soil of tropical and subtropical areas of the world." [UPa:amorgat] xref: PMID:15100990 xref: PMID:16874749 xref: PMID:17396254 is_a: UPa:UPA00499 ! pigment biosynthesis relationship: uniprot_super_pathway UPa:UPA00499 ! pigment biosynthesis [Term] id: UPa:UPA00310 name: ajmaline biosynthesis namespace: pathway def: "Biosynthesis of ajmaline, an antiarrhythmic monoterpenoid indole alkaloid. The ajmaline biosynthetic pathway expressed in the medicinal plant Rauvolfia serpentina (L.) Benth. ex Kurz. The pathway originates from rather simple precursors such as tryptamine on one side, and the monoterpenoid glucoside secologanin on the other side." [UPa:amorgat] xref: PMID:11937349 xref: PMID:12071952 xref: PMID:16874388 is_a: UPa:UPA00512 ! terpenoid indole alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00311 name: 3alpha(S)-strictosidine biosynthesis namespace: pathway def: "Biosynthesis of 3-alpha-(S)-strictosidine, an important intermediate in synthesizing indole alkaloids. Strictosidine is is a common biosynthetic precursor for more than two thousand terpene indole alkaloids (e.g production of clinically useful antitumor alkaloids vinblastine and vincristine)." [UPa:amorgat] xref: KEGG:map00901 "Indole alkaloid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:17113995 xref: PMID:7763429 is_a: UPa:UPA00512 ! terpenoid indole alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00312 name: nucleotide salvage pathway namespace: pathway def: "Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. [GO]." [UPa:amorgat] xref: GO:0043173 "biological_process:nucleotide salvage" xref: PMID:8805514 is_a: UPa:UPA00486 ! nucleotide metabolism relationship: uniprot_super_pathway UPa:UPA00486 ! nucleotide metabolism [Term] id: UPa:UPA00313 name: pyrimidine nucleotide metabolism namespace: pathway def: "Metabolism of pyrimidine nucleotides." [UPa:amorgat] xref: GO:0006220 "biological_process:pyrimidine nucleotide metabolic process" is_a: UPa:UPA00486 ! nucleotide metabolism is_a: UPa:UPA00570 ! pyrimidine metabolism relationship: uniprot_super_pathway UPa:UPA00486 ! nucleotide metabolism [Term] id: UPa:UPA00314 name: L-homocysteine biosynthesis namespace: pathway def: "Biosynthesis of homocysteine, the precursor of L-methionine, from S-adenosylhomocysteine. This reaction occurs during the activated methyl cycle." [UPa:amorgat] xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00406 ! nonprotein amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00315 name: S-adenosyl-L-methionine biosynthesis namespace: pathway def: "Biosynthesis of S-adenosyl-L-methionine (SAM, AdoMet). Conversion of L-methionine and ATP into S-adenosyl-L-methionine (AdoMet, SAM), which is required for methyltransferase reactions in the cell as well as for polyamine biosynthesis. This reaction occurs during the activated methyl cycle." [UPa:amorgat] synonym: "AdoMet biosynthesis" EXACT [] synonym: "SAM biosynthesis" EXACT [] xref: GO:0006556 "biological_process:S-adenosylmethionine biosynthetic process" xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: MetaCyc:SAM-PWY is_a: UPa:UPA00406 ! nonprotein amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00316 name: biopolymer metabolism namespace: pathway def: "The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins. [source: GO]." [UPa:amorgat] xref: GO:0043170 "biological_process:macromolecule metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00317 name: morphine degradation namespace: pathway def: "Degradation of morphine, an isoquinolin alkaloid." [UPa:amorgat] xref: GO:0071273 "biological_process:morphine catabolic process" xref: PMID:2012614 is_a: UPa:UPA00514 ! isoquinoline alkaloid degradation relationship: uniprot_super_pathway UPa:UPA00447 ! alkaloid degradation [Term] id: UPa:UPA00318 name: codeine degradation namespace: pathway def: "Degradation of codeine, an isoquinolin alkaloid." [UPa:amorgat] xref: GO:2001292 "biological_process:codeine catabolic process" xref: PMID:2012614 is_a: UPa:UPA00514 ! isoquinoline alkaloid degradation relationship: uniprot_super_pathway UPa:UPA00447 ! alkaloid degradation [Term] id: UPa:UPA00319 name: (S)-scoulerine biosynthesis namespace: pathway def: "Biosynthesis of scoulerine, an isoquinoline alkaloid. Scoulerine is is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants. Some studies shown that scoulerine is an antagonist at the alpha-2-adrenoceptor, alpha-1D-adrenoceptor and 5-HT receptor [PMID:7902181] [PMID:7952879]. It has also been found to be a GABA-A receptor agonist [PMID:14577695] [PMID:12709895]." [UPa:amorgat] synonym: "aequaline biosynthesis" EXACT [] synonym: "discretamine biosynthesis" EXACT [] xref: KEGG:map00950 "Isoquinoline alkaloid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:12709895 xref: PMID:14577695 xref: PMID:1946465 xref: PMID:7902181 xref: PMID:7952879 is_a: UPa:UPA00510 ! isoquinoline alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00320 name: biopolymer biosynthesis namespace: pathway def: "The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins. [source: GO]." [UPa:amorgat] xref: GO:0009059 "biological_process:macromolecule biosynthetic process" is_a: UPa:UPA00316 ! biopolymer metabolism [Term] id: UPa:UPA00321 name: C3 acid pathway namespace: pathway def: "C3 acid pathway is one of the three carbon fixation pathway." [UPa:amorgat] is_a: UPa:UPA00515 ! carbon fixation relationship: uniprot_super_pathway UPa:UPA00091 ! photosynthesis [Term] id: UPa:UPA00322 name: C4 acid pathway namespace: pathway def: "C4 acid pathway is one of the three carbon fixation pathway." [UPa:amorgat] is_a: UPa:UPA00515 ! carbon fixation relationship: uniprot_super_pathway UPa:UPA00091 ! photosynthesis [Term] id: UPa:UPA00323 name: CAM pathway namespace: pathway def: "Crassulacean Acid Metabolism (CAM) pathway is one of the three carbon fixation pathway." [UPa:amorgat] synonym: "Crassulacean Acid Metabolism" EXACT [] is_a: UPa:UPA00515 ! carbon fixation relationship: uniprot_super_pathway UPa:UPA00091 ! photosynthesis [Term] id: UPa:UPA00324 name: bacterial outer membrane biogenesis namespace: pathway def: "Biogenesis of bacterial outer membrane constituents." [UPa:amorgat] is_a: UPa:UPA00320 ! biopolymer biosynthesis is_a: UPa:UPA00931 ! cellular component biogenesis [Term] id: UPa:UPA00325 name: hydrocarbon metabolism namespace: pathway def: "Metabolism of hydrocarbons, organic compound consisting entirely of hydrogen and carbon. Saturated hydrocarbons are called alkanes. Unsaturated hydrocarbons with one double bond are called alkenes." [UPa:amorgat] is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00326 name: DNA replication namespace: pathway def: "The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. [GO]." [UPa:amorgat] xref: GO:0006260 "biological_process:DNA replication" is_a: UPa:UPA00485 ! genetic information processing relationship: uniprot_super_pathway UPa:UPA00485 ! genetic information processing [Term] id: UPa:UPA00327 name: ergot alkaloid biosynthesis namespace: pathway def: "Biosynthesis of ergot alkaloids." [UPa:amorgat] xref: GO:0035835 "biological_process:indole alkaloid biosynthetic process" xref: PMID:15870460 is_a: UPa:UPA00446 ! alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00328 name: secologanin biosynthesis namespace: pathway def: "Biosynthesis of secologanin, the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids." [UPa:amorgat] is_a: UPa:UPA00446 ! alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00329 name: pyrrolizidine alkaloid biosynthesis namespace: pathway def: "Biosynthesis of pyrrolizidine alkaloids. ipecac alkaloids." [UPa:amorgat] xref: GO:1901085 {source="rdfmatch"} xref: PMID:10611289 is_a: UPa:UPA00446 ! alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00330 name: tropane alkaloid biosynthesis namespace: pathway def: "Biosynthesis of tropane alkaloids." [UPa:amorgat] xref: GO:0009710 "biological_process:tropane alkaloid biosynthetic process" is_a: UPa:UPA00446 ! alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00331 name: S-adenosylmethioninamine biosynthesis namespace: pathway def: "Biosynthesis of S-adenosylmethioninamine, a precursor of spermine and spermidine polyamines, from S-adenosyl-L-methionine (AdoMet, SAM)." [UPa:amorgat] synonym: "S-adenosyl-L-methioninamine biosynthesis" EXACT [] xref: GO:0006557 "biological_process:S-adenosylmethioninamine biosynthetic process" xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00289 ! amine and polyamine biosynthesis relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00332 name: L-tryptophan degradation via pyruvate pathway namespace: pathway def: "Degradation of amino-acid L-tryptophan into pyruvate and indole. Among the multiple products of tryptophan catabolism, indole is suspected to be responsible for the cell-cycle arrest and to add a role in stationary-phase signalling [PMID:17163965]." [UPa:amorgat] synonym: "(S)-alpha-amino-beta-(3-indolyl)-propionic acid degradation" EXACT [] synonym: "2-amino-3-(1H-indol-3-yl)propanoic acid degradation" EXACT [] xref: KEGG:map00380 "Tryptophan metabolism" xref: KEGG:map00910 "Nitrogen metabolism" xref: MetaCyc:TRYPDEG-PWY xref: PMID:11479034 xref: PMID:17163965 is_a: UPa:UPA00526 ! L-tryptophan degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00333 name: L-tryptophan degradation via kynurenine pathway namespace: pathway def: "Degradation of amino-acid L-tryptophan into L-kynurenine." [UPa:amorgat] xref: GO:0019441 "biological_process:tryptophan catabolic process to kynurenine" xref: KEGG:map00380 "Tryptophan metabolism" xref: KEGG:map00630 "Glyoxylate and dicarboxylate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:TRPCAT-PWY xref: PMID:18282734 is_a: UPa:UPA00526 ! L-tryptophan degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00334 name: L-kynurenine degradation namespace: pathway def: "Degradation of L-kynurenine, a metabolite of L-tryptophan amino-acid." [UPa:amorgat] synonym: "3-anthraniloyl-L-alanine degradation" EXACT [] xref: GO:0097053 "biological_process:L-kynurenine catabolic process" xref: KEGG:map00380 "Tryptophan metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00427 ! amino-acid degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00335 name: [NiFe] hydrogenase maturation namespace: pathway def: "Maturation of [NiFe] hydrogenase, one of the three hydrogenase class with an active site based on nickel and iron." [UPa:amorgat] xref: PMID:17216401 xref: PMID:18065529 is_a: UPa:UPA00516 ! protein maturation relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00336 name: taurine degradation via aerobic pathway namespace: pathway def: "Degradation of taurine (2-aminoethanesulfonic acid), an organic acid that is abundant in the tissues of many animals (metazoa). Taurine is also found in plants, fungi, and some bacterial species, but at lower levels. Taurine is a derivative of the sulphur-containing (sulfhydryl) amino-acid, cysteine." [UPa:amorgat] synonym: "2-aminoethanesulfonic acid degradation via aerobic pathway" EXACT [] xref: KEGG:map00430 "Taurine and hypotaurine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00522 ! organosulfur degradation relationship: uniprot_super_pathway UPa:UPA00522 ! organosulfur degradation [Term] id: UPa:UPA00337 name: hopanoid biosynthesis namespace: pathway def: "Biosynthesis of hopanoids, pentacyclic compounds similar to sterols, whose primary function is to improve plasma membrane fluidity in prokaryotes." [UPa:amorgat] xref: GO:0019746 "biological_process:hopanoid biosynthetic process" is_a: UPa:UPA00464 ! secondary metabolite biosynthesis is_a: UPa:UPA00518 ! hopanoid metabolism relationship: uniprot_super_pathway UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00338 name: alkanesulfonate degradation namespace: pathway def: "In the absence of sulfate, a number of yeasts can use alkanesulfonates (aliphatic sulfonates), such as taurine, cysteate, and isethionate, as alternative sulfur sources. Sulfonate utilization by Saccharomyces cerevisiae occurs only under aerobic conditions, is independent of sulfate-utilizing enzymes, and requires sulfite reductase, consistent with the formation of sulfite prior to assimilation." [UPa:amorgat] synonym: "aliphatic sulfonate degradation" EXACT [] xref: GO:0046306 "biological_process:alkanesulfonate catabolic process" xref: PMID:10482536 is_a: UPa:UPA00522 ! organosulfur degradation relationship: uniprot_super_pathway UPa:UPA00522 ! organosulfur degradation [Term] id: UPa:UPA00339 name: mannose metabolism namespace: pathway def: "Metabolism of the aldohexose mannose (the C-2 epimer of glucose). The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. [GO]." [UPa:amorgat] xref: GO:0006013 "biological_process:mannose metabolic process" is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00340 name: acetyl-CoA biosynthesis namespace: pathway def: "Biosynthesis of acetyl-CoA, an important molecule in metabolism, used in many biochemical reactions." [UPa:amorgat] xref: GO:0006085 "biological_process:acetyl-CoA biosynthetic process" xref: KEGG:map00410 "beta-Alanine metabolism" xref: KEGG:map00430 "Taurine and hypotaurine metabolism" xref: KEGG:map00620 "Pyruvate metabolism" xref: KEGG:map00640 "Propanoate metabolism" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map00720 "Carbon fixation pathways in prokaryotes" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00415 ! metabolic intermediate biosynthesis relationship: uniprot_super_pathway UPa:UPA00415 ! metabolic intermediate biosynthesis [Term] id: UPa:UPA00341 name: hyaluronan biosynthesis namespace: pathway def: "Biosynthesis of hyaluronan, a non-sulfated glycosaminoglycan. Hyaluronan is synthesized by a class of integral membrane proteins called hyaluronan synthases. Vertebrates have three types: HAS1, HAS2, and HAS3. These enzymes lengthen hyaluronan by repeatedly adding glucuronic acid and N-acetylglucosamine to the nascent polysaccharide." [UPa:amorgat] synonym: "hyaluronate biosynthesis" EXACT [] synonym: "hyaluronic acid biosynthesis" EXACT [] xref: GO:0030213 "biological_process:hyaluronan biosynthetic process" is_a: UPa:UPA00484 ! glycan biosynthesis is_a: UPa:UPA00519 ! hyaluronan metabolism relationship: uniprot_super_pathway UPa:UPA00484 ! glycan biosynthesis [Term] id: UPa:UPA00342 name: N-acetylmuramate degradation namespace: pathway def: "Degradation of N-acetylmuramic acid, an amino-sugar." [UPa:amorgat] synonym: "MurNAc degradation" EXACT [] xref: GO:0097173 "biological_process:N-acetylmuramic acid catabolic process" is_a: UPa:UPA00627 ! amino-sugar degradation relationship: uniprot_super_pathway UPa:UPA00216 ! amino-sugar metabolism [Term] id: UPa:UPA00343 name: 1,6-anhydro-N-acetylmuramate degradation namespace: pathway def: "Degradation of anhydro-N-acetylmuramate, an amino-sugar." [UPa:amorgat] synonym: "anhMurNAc degradation" EXACT [] xref: GO:0097175 "biological_process:1,6-anhydro-N-acetyl-beta-muramic acid catabolic process" is_a: UPa:UPA00627 ! amino-sugar degradation relationship: uniprot_super_pathway UPa:UPA00216 ! amino-sugar metabolism [Term] id: UPa:UPA00344 name: molybdopterin biosynthesis namespace: pathway def: "Biosynthesis of molybdopterin, an essential cofactor for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. [GO:0032324]." [UPa:amorgat] synonym: "Mo-pterin biosynthesis" EXACT [] is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00345 name: polypeptide chain elongation namespace: pathway def: "Elongation stage in protein biosynthesis." [UPa:amorgat] synonym: "protein elongation" EXACT [] xref: GO:0006414 "biological_process:translational elongation" is_a: UPa:UPA00458 ! protein biosynthesis relationship: uniprot_super_pathway UPa:UPA00458 ! protein biosynthesis [Term] id: UPa:UPA00346 name: dibenzothiophene degradation namespace: pathway def: "Desulfurization of dibenzothiophene (DBT) into 2-hydroxybiphenyl (2-HBP)." [UPa:amorgat] synonym: "2-HBP biosynthesis" EXACT [] synonym: "2-hydroxybiphenyl biosynthesis" EXACT [] synonym: "DBT desulfurization" EXACT [] xref: GO:0018896 "biological_process:dibenzothiophene catabolic process" xref: PMID:7574582 is_a: UPa:UPA00096 ! sulfur metabolism relationship: uniprot_super_pathway UPa:UPA00096 ! sulfur metabolism [Term] id: UPa:UPA00347 name: hydrocarbon biosynthesis namespace: pathway def: "Biosynthesis of hydrocarbons, organic compound consisting entirely of hydrogen and carbon. Saturated hydrocarbons are called alkanes. Unsaturated hydrocarbons with one double bond are called alkenes." [UPa:amorgat] is_a: UPa:UPA00325 ! hydrocarbon metabolism [Term] id: UPa:UPA00348 name: 2-(2,4-dichlorophenoxy)propanoate degradation namespace: pathway def: "Degradation of (2,4-dichlorophenoxy)propanoate (dichlorprop, 2,4-DP), a chlorinated phenoxy herbicid." [UPa:amorgat] synonym: "2,4-DP degradation" EXACT [] synonym: "dichlorprop degradation" EXACT [] xref: PMID:12501996 is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00349 name: chitin degradation namespace: pathway def: "Degradation of chitin, a glycan composed of beta-1,4-linked N-acetyl-D-glucosamine, into N-acetyl-D-glucosamine." [UPa:amorgat] synonym: "2,4-DP degradation" EXACT [] synonym: "Dichlorprop degradation" EXACT [] xref: GO:0006032 "biological_process:chitin catabolic process" is_a: UPa:UPA00442 ! glycan degradation relationship: uniprot_super_pathway UPa:UPA00442 ! glycan degradation [Term] id: UPa:UPA00350 name: beta-D-glucan degradation namespace: pathway def: "Degradation of beta-D-glucan." [UPa:amorgat] is_a: UPa:UPA00441 ! glycan metabolism relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00351 name: L-glutamate degradation namespace: pathway def: "Degradation of L-glutamate amino-acid." [UPa:amorgat] xref: GO:0006538 "biological_process:glutamate catabolic process" xref: PMID:11759672 xref: PMID:4813895 is_a: UPa:UPA00201 ! L-glutamate metabolism is_a: UPa:UPA00427 ! amino-acid degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00352 name: hydrocarbon degradation namespace: pathway def: "Degradation of hydrocarbons, organic compound consisting entirely of hydrogen and carbon. Saturated hydrocarbons are called alkanes. Unsaturated hydrocarbons with one double bond are called alkenes." [UPa:amorgat] is_a: UPa:UPA00325 ! hydrocarbon metabolism [Term] id: UPa:UPA00353 name: carbohydrate sulfation namespace: pathway def: "Sulfation is a critical modification in many instances of biological recognition." [UPa:amorgat] is_a: UPa:UPA00516 ! protein maturation relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00354 name: eIF5A hypusination namespace: pathway def: "Post-translational modification of archaea and eukaryotic translation initiation factor 5A (eIF5A), by covalent binding of hypusine to a lysine residue. Hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine) is a polyamine-derived amino-acid. The biosynthesis of hypusine occurs posttranslationally by modification of a single lysine residue. Translation initiation factor 5A (eIF5A), highly conserved throughout eukaryotes and some archaea, is the only known cellular protein to contain the unique polyamine-derived amino-acid hypusine. The name hypusine reflects the composition of this amino-acid, a combination of hydroxyputrescine and lysine. The unique feature of the hypusine modification is the strict specificity of the enzymes toward its substrate protein, eIF5A. Hypusine is formed in a novel posttranslational modification that involves two enzymes, deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH). [PMID:16452303; PMID:17476569]." [UPa:amorgat] xref: PMID:16452303 xref: PMID:17213197 xref: PMID:17476569 is_a: UPa:UPA00516 ! protein maturation relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00355 name: coenzyme M biosynthesis namespace: pathway def: "De novo biosynthesis of coenzyme M (2-mercaptoethanesulfonic acid, HS-CoM). Warning, this pathway is not fully defined, the last part of the pathway is still missing." [UPa:amorgat] synonym: "2-mercaptoethanesulfonate biosynthesis" EXACT [] synonym: "de novo coenzyme M biosynthesis" EXACT [] synonym: "HS-CoM biosynthesis" EXACT [] xref: GO:0019295 "biological_process:coenzyme M biosynthetic process" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00356 name: ADP-L-glycero-beta-D-manno-heptose biosynthesis namespace: pathway def: "Biosynthesis of ADP-L-glycero-beta-D-manno-heptose (ADP-L-beta-D-heptose), a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate." [UPa:amorgat] synonym: "ADP-L-beta-D-heptose biosynthesis" EXACT [] synonym: "ADP-L-glycero-D-manno-heptose biosynthesis" EXACT [] xref: GO:0097171 "biological_process:ADP-L-glycero-beta-D-manno-heptose biosynthetic process" xref: KEGG:map00540 "Lipopolysaccharide biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:11751812 xref: PMID:12101286 xref: PMID:16030223 is_a: UPa:UPA00301 ! LPS oligosaccharide biosynthesis is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00357 name: 3-deoxy-D-manno-octulosonate biosynthesis namespace: pathway def: "Biosynthesis of 3-deoxy-D-manno-octulosonate (KDO, keto-deoxyoctulonate). In general, KDO residues are normally found in the lipopolysaccharide inner core of gram-negative bacteria, but in K. pneumoniae, this KDO residue provides the ligation site for O polysaccharide. The conserved Klebsiella outer core contains the unusual trisaccharide 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo)-(2,6)-GlcN-(1,4)-GalUA. lipopolysaccharide (LPS)." [UPa:amorgat] synonym: "KDO biosynthesis" EXACT [] synonym: "keto-deoxyoctulonate biosynthesis" EXACT [] xref: KEGG:map00540 "Lipopolysaccharide biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:16159798 is_a: UPa:UPA00412 ! carbohydrate biosynthesis relationship: uniprot_super_pathway UPa:UPA00412 ! carbohydrate biosynthesis [Term] id: UPa:UPA00358 name: CMP-3-deoxy-D-manno-octulosonate biosynthesis namespace: pathway def: "Biosynthesis of CMP-3-deoxy-D-manno-octulosonate (CMP-KDO, CMP-keto-deoxyoctulonate), a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS)." [UPa:amorgat] synonym: "CMP-KDO biosynthesis" EXACT [] synonym: "CMP-keto-deoxyoctulonate biosynthesis" EXACT [] xref: GO:0033468 "biological_process:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process" xref: KEGG:map00540 "Lipopolysaccharide biosynthesis" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00301 ! LPS oligosaccharide biosynthesis is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00359 name: lipid IV(A) biosynthesis namespace: pathway def: "Biosynthesis of lipid IV(A), the endotoxically inactive LPS lipid A precursor. Lipid A is one of the three components of lipopolysaccharide (LPS). It contains unusual fatty acids (e.g. hydroxy-myristic acid) and is inserted into the outer membrane while the rest of the LPS projects from the surface. Lipid A, the potent macrophage-activating component primarily responsible for LPS endotoxin activity, is a phosphorylated glucosamine disaccharide carrying long-chain saturated fatty acid (FA) substituents that anchor LPS in the outer membrane. Lipid A is similar for all Gram-negative Enterobacteriaceae, and synthetic lipid A produces effects identical to that isolated from Escherichia coli in both in vitro and in vivo endotoxin tests." [UPa:amorgat] synonym: "2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bis(dihydrogen phosphate) biosynthesis" EXACT [] xref: KEGG:map00540 "Lipopolysaccharide biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:17163638 is_a: UPa:UPA00030 ! lipopolysaccharide biosynthesis is_a: UPa:UPA00506 ! glycolipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00506 ! glycolipid biosynthesis [Term] id: UPa:UPA00360 name: KDO(2)-lipid A biosynthesis namespace: pathway def: "Biosynthesis of KDO(2)-lipid A, a lipopolysaccharide (LPS) component." [UPa:amorgat] synonym: "di[3-deoxy-D-manno-octulosonyl]-lipid A biosynthesis" EXACT [] xref: GO:0036104 "biological_process:Kdo2-lipid A biosynthetic process" xref: KEGG:map00540 "Lipopolysaccharide biosynthesis" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00506 ! glycolipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00506 ! glycolipid biosynthesis [Term] id: UPa:UPA00361 name: D-allose degradation namespace: pathway def: "Degradation of D-allose, an all-cis hexose utilized by some bacteria (Aerobacter aerogenes, E. coli, etc). D-allose is converted into fructose 6-phosphate." [UPa:amorgat] xref: GO:0019316 "biological_process:D-allose catabolic process" is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA00362 name: L-valine degradation namespace: pathway def: "Degradation of L-valine, one of the three main branched chain amino-acids (BCAAs), along with L-leucine and L-isoleucine. In plants, branched-chain amino-acids are synthesized in chloroplasts, whereas the degradation takes place in mitochondria." [UPa:amorgat] xref: GO:0006574 "biological_process:valine catabolic process" is_a: UPa:UPA00431 ! Branched-chain amino-acid degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00363 name: L-leucine degradation namespace: pathway def: "Degradation of L-leucine, one of the three main branched chain amino-acids (BCAAs), along with L-valine and L-isoleucine. In plants, branched-chain amino-acids are synthesized in chloroplasts, whereas the degradation takes place in mitochondria." [UPa:amorgat] xref: GO:0006552 "biological_process:leucine catabolic process" xref: KEGG:map00280 "Valine, leucine and isoleucine degradation" xref: KEGG:map00290 "Valine, leucine and isoleucine biosynthesis" xref: KEGG:map00966 "Glucosinolate biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00431 ! Branched-chain amino-acid degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00364 name: L-isoleucine degradation namespace: pathway def: "Degradation of L-isoleucine, one of the three main branched chain amino-acids (BCAAs), along with L-valine and L-leucine. In plants, branched-chain amino-acids are synthesized in chloroplasts, whereas the degradation takes place in mitochondria." [UPa:amorgat] xref: GO:0006550 "biological_process:isoleucine catabolic process" is_a: UPa:UPA00431 ! Branched-chain amino-acid degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00365 name: vindoline biosynthesis namespace: pathway def: "Biosynthesis of vindoline, an indole alkaloid, precursor of vinblastine and vincristine." [UPa:amorgat] xref: GO:1900985 {source="rdfmatch"} xref: KEGG:map00901 "Indole alkaloid biosynthesis" xref: PMID:15200179 xref: PMID:16262708 xref: PMID:24108213 is_a: UPa:UPA00512 ! terpenoid indole alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00366 name: thiocyanate degradation namespace: pathway def: "Degradation of thiocyanate to carbonyl sulfide and ammonia." [UPa:amorgat] xref: GO:0046265 "biological_process:thiocyanate catabolic process" xref: PMID:17222425 is_a: UPa:UPA00522 ! organosulfur degradation relationship: uniprot_super_pathway UPa:UPA00522 ! organosulfur degradation [Term] id: UPa:UPA00367 name: testosterone biosynthesis namespace: pathway def: "Biosynthesis of testosterone, a steroid hormone from the androgen group. Testosterone is primarily secreted in the testes of males and the ovaries of females although small amounts are secreted by the adrenal glands." [UPa:amorgat] xref: GO:0061370 "biological_process:testosterone biosynthetic process" is_a: UPa:UPA00440 ! steroid hormone biosynthesis relationship: uniprot_super_pathway UPa:UPA00435 ! hormone biosynthesis [Term] id: UPa:UPA00368 name: ethylene biosynthesis namespace: pathway def: "Biosynthesis of ethylene, an unsaturated hydrocarbon that contains one double bond (the simplest alkene). It acts as hormon in plant where it is essential for proper development, growth and survival. It is responsible for signaling changes during germination, flower and fruit development, the onset of plant defense responses, and cross-talk with other plant hormones." [UPa:amorgat] xref: GO:0009693 "biological_process:ethylene biosynthetic process" is_a: UPa:UPA00305 ! alkene biosynthesis [Term] id: UPa:UPA00369 name: tabtoxinine-beta-lactam biosynthesis namespace: pathway def: "Biosynthesis of tabtoxinine-beta-lactam, an irreversible inhibitor of glutamine synthetase produced by several pathovars of Pseudomonas syringae." [UPa:amorgat] xref: PMID:16495645 xref: PMID:2881927 xref: PMID:8990304 is_a: UPa:UPA00477 ! phytotoxin biosynthesis relationship: uniprot_super_pathway UPa:UPA00477 ! phytotoxin biosynthesis [Term] id: UPa:UPA00370 name: sulfite reduction namespace: pathway def: "Sulfite reduction aims at producing hydrogen sulfide from sulfite." [UPa:amorgat] xref: PMID:1704886 is_a: UPa:UPA00096 ! sulfur metabolism relationship: uniprot_super_pathway UPa:UPA00096 ! sulfur metabolism [Term] id: UPa:UPA00371 name: sucrose biosynthesis namespace: pathway def: "Biosynthesis of sucrose (saccharose, 1-alpha-D-glucopyranosyl-2-beta-D-fructofuranoside), a disaccharide composed of glucose and fructose. In most plants, sucrose is the main product of photosynthesis that is exported from the leaves to fuel growth and synthesis of storage reserves, such as starch and oil, and sucrose itself is often accumulated by plant cells to protect against the effects of dehydration under drought, salinity, or cold stress. Apart from plants, some species of cyanobacteria also synthesize sucrose, often in response to osmotic stress." [UPa:amorgat] synonym: "1-alpha-D-glucopyranosyl-2-beta-D-fructofuranoside biosynthesis" EXACT [] synonym: "saccharose biosynthesis" EXACT [] xref: GO:0005986 "biological_process:sucrose biosynthetic process" xref: KEGG:map00500 "Starch and sucrose metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00484 ! glycan biosynthesis [Term] id: UPa:UPA00372 name: 3,4',5-trihydroxystilbene biosynthesis namespace: pathway def: "Biosynthesis of 3,4',5-trihydroxystilbene (resveratrol), a phytoalexin produced by several plants." [UPa:amorgat] synonym: "resveratrol biosynthesis" EXACT [] xref: KEGG:map00130 "Ubiquinone and other terpenoid-quinone biosynthesis" xref: KEGG:map00360 "Phenylalanine metabolism" xref: KEGG:map00940 "Phenylpropanoid biosynthesis" xref: KEGG:map00945 "Stilbenoid, diarylheptanoid and gingerol biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:16885328 is_a: UPa:UPA00422 ! stilbenoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00421 ! phytoalexin biosynthesis [Term] id: UPa:UPA00373 name: pinosylvin biosynthesis namespace: pathway def: "Biosynthesis of pinosylvin, a pre-infectious stilbenoid toxin. Pinosylvin is synthesized prior to infection, contrary to phytoalexins which are synthesized during infection. It is present in the heart-wood of Pineceal. It is a fungitoxin protecting the wood from fungal infection." [UPa:amorgat] is_a: UPa:UPA00422 ! stilbenoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00421 ! phytoalexin biosynthesis [Term] id: UPa:UPA00374 name: hydropinosylvin biosynthesis namespace: pathway def: "Dihydropinosylvin biosynthesis." [UPa:amorgat] is_a: UPa:UPA00422 ! stilbenoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00421 ! phytoalexin biosynthesis [Term] id: UPa:UPA00375 name: wybutosine-tRNA(Phe) biosynthesis namespace: pathway def: "Biosynthesis of wybutosine (yW), a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic and archaeal phenylalanine tRNA." [UPa:amorgat] xref: PMID:16642040 xref: PMID:17150819 is_a: UPa:UPA00482 ! tRNA post-transcriptional modification relationship: uniprot_super_pathway UPa:UPA00481 ! tRNA modification [Term] id: UPa:UPA00376 name: auxin conjugation namespace: pathway def: "Conjugation of auxin (indole-3-acetic acid, IAA) to many kinds of molecules is part of a regulatory mechanism for controlling IAA levels through sequestration and reuse, or as an entry into catabolism. IAA in plants occurs in both conjugated and free forms, and there is increasing evidence that the ratio of free to conjugated IAA is controlled by tissue-specific and developmentally regulated processes. The use of conjugation by plants to regulate IAA levels appears to have become increasingly more important as plants evolved from liverworts to mosses and tracheophytes." [UPa:amorgat] synonym: "IAA conjugation" EXACT [] synonym: "indole-3-acetate conjugation" EXACT [] synonym: "indole-3-acetic acid conjugation" EXACT [] synonym: "indoleacetic acid conjugation" EXACT [] xref: PMID:11830675 xref: PMID:17509086 xref: PMID:8085154 is_a: UPa:UPA00887 ! auxin metabolism relationship: uniprot_super_pathway UPa:UPA00437 ! plant hormone metabolism [Term] id: UPa:UPA00377 name: sterigmatocystin biosynthesis namespace: pathway def: "Biosynthesis of sterigmatocystin (ST), a carcinogenic mycotoxin. Sterigmatocystin is among the most toxic, mutagenic, and carcinogenic natural products known. This polyketide-derived secondary metabolite is produced by numerous fungi species." [UPa:amorgat] xref: GO:0045461 "biological_process:sterigmatocystin biosynthetic process" xref: PMID:15022028 xref: PMID:19537208 xref: PMID:7642507 xref: PMID:8643646 is_a: UPa:UPA00473 ! polyketide biosynthesis is_a: UPa:UPA00478 ! mycotoxin biosynthesis relationship: uniprot_super_pathway UPa:UPA00478 ! mycotoxin biosynthesis [Term] id: UPa:UPA00378 name: protein glycosylation namespace: pathway def: "Protein glycosylation (the addition of saccharides to proteins) is one of the principal post-translational modification steps in the synthesis of membrane and secreted proteins. It is an enzyme-directed site-specific process, as opposed to the non-enzymatic chemical reaction of glycation. Two types of glycosylation exist: * N-linked glycosylation to the amide nitrogen of asparagine side chains * O-linked glycosylation to the hydroxy oxygen of serine and threonine side chains." [UPa:amorgat] xref: GO:0006486 "biological_process:protein glycosylation" xref: PMID:16510493 is_a: UPa:UPA00460 ! protein modification relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00379 name: L-histidine degradation into L-glutamate namespace: pathway def: "Nonoxidative degradation of L-histidine into L-glutamate." [UPa:amorgat] xref: GO:0019556 "biological_process:histidine catabolic process to glutamate and formamide" xref: GO:0019557 "biological_process:histidine catabolic process to glutamate and formate" xref: KEGG:map00340 "Histidine metabolism" xref: KEGG:map00630 "Glyoxylate and dicarboxylate metabolism" xref: KEGG:map00670 "One carbon pool by folate" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:13117923 xref: PMID:14367318 is_a: UPa:UPA00492 ! L-histidine degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00380 name: D-arabinitol metabolism namespace: pathway def: "Metabolism of D-arabinitol, an acyclic pentitol. Candida albicans produces large amount of D-arabinitol, but the biosynthetic pathway is not yet known." [UPa:amorgat] synonym: "D-arabitol metabolism" EXACT [] xref: GO:0051161 "biological_process:arabitol metabolic process" xref: PMID:8407803 is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00381 name: brassinosteroid biosynthesis namespace: pathway def: "Biosynthesis of brassinosteroids (brassins), a group of plant hormones, also called plant growth regulators. The most known example of brassinosteroids is brassinolide." [UPa:amorgat] synonym: "Brassin biosynthesis" EXACT [] xref: GO:0016132 "biological_process:brassinosteroid biosynthetic process" is_a: UPa:UPA00438 ! plant hormone biosynthesis is_a: UPa:UPA00440 ! steroid hormone biosynthesis relationship: uniprot_super_pathway UPa:UPA00438 ! plant hormone biosynthesis [Term] id: UPa:UPA00382 name: oxylipin biosynthesis namespace: pathway def: "Biosynthesis of oxylipins, a group of acyclic (or cyclic) oxidation products derived from the catabolism of fatty acids. Oxylipins regulate many defense and developmental pathways in plants." [UPa:amorgat] synonym: "octadecanoid biosynthesis" EXACT [] xref: GO:0031408 "biological_process:oxylipin biosynthetic process" is_a: UPa:UPA00199 ! fatty acid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00383 name: arachidonate metabolism namespace: pathway def: "Metabolism of arachidonic acid, an omega-6 fatty acid (a carboxylic acid with a 20-carbon chain and four cis double bonds, the first double bond is located at the sixth carbon from the omega end). Arachidonic acid is a polyunsaturated fatty acid that is present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositides) of membranes of the body's cells. It is also involved in cellular signaling as a second messenger." [UPa:amorgat] xref: GO:0019369 "biological_process:arachidonic acid metabolic process" is_a: UPa:UPA00199 ! fatty acid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00384 name: ethylene biosynthesis via S-adenosyl-L-methionine namespace: pathway def: "Biosynthesis of ethylene, an unsaturated hydrocarbon that contains one double bond (the simplest alkene). It acts as hormon in plant where it is essential for proper development, growth and survival. It is responsible for signaling changes during germination, flower and fruit development, the onset of plant defense responses, and cross-talk with other plant hormones." [UPa:amorgat] xref: GO:0009693 "biological_process:ethylene biosynthetic process" xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: MetaCyc:ETHYL-PWY xref: PMID:16492477 xref: PMID:16524685 is_a: UPa:UPA00368 ! ethylene biosynthesis is_a: UPa:UPA00438 ! plant hormone biosynthesis relationship: uniprot_super_pathway UPa:UPA00305 ! alkene biosynthesis [Term] id: UPa:UPA00385 name: ethylene biosynthesis via 2-oxoglutarate namespace: pathway def: "Biosynthesis of ethylene via 2-oxoglutarate pathway. Bacterial ethylene-forming enzyme (EFE) catalyzes oxygenation of 2-oxoglutarate to produce ethylene and carbon dioxide in contrast to a plant enzyme which uses 1-aminocyclopropane-1-carboxylic acid as a substrate." [UPa:amorgat] xref: GO:0009693 "biological_process:ethylene biosynthetic process" xref: PMID:10805596 xref: PMID:1445291 xref: PMID:1770346 xref: PMID:7952184 is_a: UPa:UPA00368 ! ethylene biosynthesis relationship: uniprot_super_pathway UPa:UPA00305 ! alkene biosynthesis [Term] id: UPa:UPA00386 name: carotenoid biosynthesis namespace: pathway def: "Biosynthesis of carotenoids, a group of essential photoprotective and antioxidant pigments that are naturally occurring in plants and some other photosynthetic organisms like algae, some types of fungus and some bacteria. There are over 600 known carotenoids; they are split into two classes, xanthophylls and carotenes. The most important function of carotenoid pigments, especially beta-carotene in higher plants, is to protect organisms against photooxidative damage. Carotenoid biosynthesis involves a series of desaturations, cyclizations, hydroxylations and epoxydations commencing with the formation of phytoene." [UPa:amorgat] xref: GO:0016117 "biological_process:carotenoid biosynthetic process" xref: PMID:11884677 is_a: UPa:UPA00416 ! isoprenoid biosynthesis is_a: UPa:UPA00499 ! pigment biosynthesis relationship: uniprot_super_pathway UPa:UPA00416 ! isoprenoid biosynthesis [Term] id: UPa:UPA00387 name: astaxanthin biosynthesis namespace: pathway def: "Biosynthesis of astaxanthin, an abundant carotenoid found in marine animals, including salmonids and crustaceans. Astaxanthin has interest not only as a pigmentation source but also as a potent antioxidative reagent that can delay aging and the onset of degenerative diseases in animals." [UPa:amorgat] synonym: "3,3'-dihydroxy-beta,beta-carotene-4,4'-dione biosynthesis" EXACT [] synonym: "AXT biosynthesis" EXACT [] xref: GO:1901815 {source="rdfmatch"} xref: PMID:16434154 is_a: UPa:UPA00419 ! xantophyll biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00388 name: neoxanthin biosynthesis namespace: pathway def: "Biosynthesis of neoxanthin, an allenic xantophyll carotenoid thought to have two key roles as part of LHC's (light-harvesting complexes) and as a precursor to the plant growth hormone abscisic acid (ABA). Neoxanthin is recognized as the last product of carotenoid synthesis in green plants." [UPa:amorgat] synonym: "(3S,5R,6R,3'S,5'R,6'S)-6,7-didehydro-5',6'-epoxy-5,6,5',6'-tetrahydro-beta,beta-carotene-3,5,3'-triol biosynthesis" EXACT [] xref: GO:1901833 {source="rdfmatch"} xref: PMID:11029576 is_a: UPa:UPA00419 ! xantophyll biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00389 name: geranylgeranyl diphosphate biosynthesis namespace: pathway def: "Biosynthesis of geranylgeranyl-PP (geranylgeranyl diphosphate), a precursor of terpenes and terpenoids." [UPa:amorgat] synonym: "geranylgeranyl pyrophosphate biosynthesis" EXACT [] synonym: "geranylgeranyl-PP biosynthesis" EXACT [] xref: GO:0033386 "biological_process:geranylgeranyl diphosphate biosynthetic process" xref: KEGG:map00900 "Terpenoid backbone biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00416 ! isoprenoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00416 ! isoprenoid biosynthesis [Term] id: UPa:UPA00390 name: gibberellin biosynthesis namespace: pathway def: "Biosynthesis of gibberellins (GAs), a large family of plant growth substances with distinct functions during the whole life cycle of higher plants. Gibberellins are involved in promotion of stem elongation, mobilization of food reserves in seeds and other processes. Gibberellin was first isolated as a superelongation-promoting diterpenoid from the fungus, Gibberella fujikuroi. G. fujikuroi uses different GA biosynthetic intermediates from those in plants." [UPa:amorgat] xref: GO:0009686 "biological_process:gibberellin biosynthetic process" is_a: UPa:UPA00438 ! plant hormone biosynthesis relationship: uniprot_super_pathway UPa:UPA00438 ! plant hormone biosynthesis [Term] id: UPa:UPA00391 name: 7-cyano-7-deazaguanine biosynthesis namespace: pathway def: "Biosynthesis of 7-cyano-7-deazaguanine (preQ0), a 7-deazapurine derivative, precursor of queuosine and archaeosine." [UPa:amorgat] synonym: "7-cyano-7-carbaguanine biosynthesis" EXACT [] synonym: "pre-queuosine 0 biosynthesis" EXACT [] synonym: "preQ0 biosynthesis" EXACT [] xref: PMID:12697167 xref: PMID:14660578 xref: PMID:15767583 xref: PMID:16199558 is_a: UPa:UPA00524 ! purine base biosynthesis relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00392 name: tRNA-queuosine biosynthesis namespace: pathway def: "In most eubacterial and eukaryotic organisms the genetically encoded guanosine in the anticodon wobble position 34 of tRNA(His), tRNA(Tyr), tRNA(Asp) and tRNA(Asn) is replaced by the hypermodified nucleoside queuosine. The biosynthesis of queuosine commences outside of any tRNA with GTP which is converted to preQ0 (7-cyano-7-deazaguanine) in a poorly characterized pathway. Compound preQ0 is a precursor of archaeosine too. Hence, its biosynthesis is described in an independant pathway. The cyano group of preQ0 is reduced to a primary amine resulting in the formation of preQ1 (queuine). The purine scaffold of queuosine is replaced by a 7-deazapurine substituted with a dihydroxycyclopentenyl-aminomethyl moiety 7-aminomethyl-7-carbaguanine). Although no clearly defined function of queuosine has been established yet, Grimm et al [PMID:17083917] suggests a role in fine tuning of translational fidelity and speed." [UPa:amorgat] xref: GO:0008616 "biological_process:queuosine biosynthetic process" xref: PMID:12731872 xref: PMID:15822125 xref: PMID:17083917 xref: PMID:17384645 xref: PMID:19414587 is_a: UPa:UPA00481 ! tRNA modification relationship: uniprot_super_pathway UPa:UPA00481 ! tRNA modification [Term] id: UPa:UPA00393 name: archaeosine-tRNA biosynthesis namespace: pathway def: "Biosynthesis of archaeosine, an archaea-specific modified base. Archaeosine (7-formamidino-7-deazaguanosine) is a structural variant of the hypermodified nucleoside 7-deazaguanosine. The biosynthesis pathway starts with archaeosine tRNA-guanine transglycosylase (ArcTGT) which catalyzes the exchange of guanine at position 15 in the D-loop of archaeal tRNAs with a free 7-cyano-7-deazaguanine (preQ(0)) base." [UPa:amorgat] xref: PMID:10862614 xref: PMID:12054814 xref: PMID:16407303 is_a: UPa:UPA00481 ! tRNA modification relationship: uniprot_super_pathway UPa:UPA00481 ! tRNA modification [Term] id: UPa:UPA00394 name: urate degradation namespace: pathway def: "Degradation of uric acid, a key compound in the degradation of purines. The ureide pathway, which mediates the oxidative degradation of uric acid to (S)-allantoin, represents the late stage of purine catabolism in most organisms. The metabolism of uric acid has a pivotal role in transforming the nitrogen that is fixed in leguminous plants and also plays a crucial role in some bacteria under nitrogen-limited conditions." [UPa:amorgat] synonym: "(S)-allantoin biosynthesis" EXACT [] synonym: "ureide pathway" EXACT [] synonym: "uric acid degradation" EXACT [] xref: GO:0019628 "biological_process:urate catabolic process" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:16462750 xref: PMID:16485000 xref: PMID:17567580 is_a: UPa:UPA00407 ! ureide metabolism is_a: UPa:UPA00595 ! purine base degradation relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00395 name: (S)-allantoin degradation namespace: pathway def: "Anaerobic utilization of (S)-allantoin, a diureide of glyoxylic acid, as nitrogen source." [UPa:amorgat] synonym: "(2,5-dioxo-4-imidazolidinyl)urea degradation" EXACT [] synonym: "5-ureidohydantoin degradation" EXACT [] synonym: "anaerobic allantoin utilization" EXACT [] synonym: "glyoxyldiureide degradation" EXACT [] xref: GO:0000256 "biological_process:allantoin catabolic process" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:12460564 xref: PMID:16546208 is_a: UPa:UPA00407 ! ureide metabolism relationship: uniprot_super_pathway UPa:UPA00045 ! nitrogen metabolism [Term] id: UPa:UPA00396 name: aminophosphonate metabolism namespace: pathway def: "Metabolism of aminophosphonates, amino-acid derivatives that contain a phosphonic acid moiety (C-PO(OH)2 or C-PO(OR)2)." [UPa:amorgat] xref: GO:0033051 "biological_process:aminophosphonate metabolic process" is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00397 name: aminophosphonate biosynthesis namespace: pathway def: "Biosynthesis of aminophosphonates, amino-acid derivatives that contain a phosphonic acid moiety (C-PO(OH)2 or C-PO(OR)2)." [UPa:amorgat] is_a: UPa:UPA00396 ! aminophosphonate metabolism is_a: UPa:UPA00960 ! phosphonate biosynthesis [Term] id: UPa:UPA00398 name: cofactor metabolism namespace: pathway def: "The chemical reactions and physical changes of a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [UPa:amorgat] xref: GO:0051186 "biological_process:cofactor metabolic process" is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00399 name: cofactor biosynthesis namespace: pathway def: "The formation from simpler components of a cofactor, a non-protein chemical substance that is tightly bound to an enzyme and is required for catalysis. Cofactors can be considered 'helper molecules/ions' that assist in biochemical transformations. Coenzyme biosynthesis pathways, e.g coenzyme A biosynthesis are considered under this pathway-category." [UPa:amorgat] xref: GO:0051188 "biological_process:cofactor biosynthetic process" is_a: UPa:UPA00398 ! cofactor metabolism [Term] id: UPa:UPA00400 name: purine base metabolism namespace: pathway def: "Metabolism of purine, a heterocyclic aromatic organic compound consisting of a pyrimidine ring fused to an imidazole ring. Purines make up one of the two groups of nitrogenous bases, Pyrimidines make up the other group. These bases make up a crucial part of both deoxyribonucleotides and ribonucleotides, and the basis for the universal genetic code. The general term purines also refers to substituted purines and their tautomers." [UPa:amorgat] xref: GO:0006144 "biological_process:purine nucleobase metabolic process" is_a: UPa:UPA00523 ! heterocycle metabolism [Term] id: UPa:UPA00401 name: amino-acid metabolism namespace: pathway def: "metabolism of amino-acids, a group of organic compound containing an amino group (NH2), a carboxylic acid group (COOH), and any of various side groups, especially any of the 20 compounds that have the basic formula NH2CHRCOOH, and that link together by peptide bonds to form proteins or that function as chemical messengers and as intermediates in metabolism. Amino-acids are the precursors of many molecules such as purines, pyrimidines, histamines, adrenaline and melanin." [UPa:amorgat] synonym: "AA metabolism" EXACT [] xref: GO:0006520 "biological_process:cellular amino acid metabolic process" is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00402 name: amino-acid biosynthesis namespace: pathway def: "The formation from simpler components of amino-acids, organic acids containing one or more amino substituents." [UPa:amorgat] synonym: "naturally-occuring amino-acid biosynthesis" EXACT [] xref: GO:0008652 "biological_process:cellular amino acid biosynthetic process" is_a: UPa:UPA00401 ! amino-acid metabolism [Term] id: UPa:UPA00403 name: proteinogenic amino-acid biosynthesis namespace: pathway def: "The chemical reactions and pathways resulting in the formation of any amino-acid that normally occur as a constituent residue of proteins [source: GO]." [UPa:amorgat] synonym: "protein amino-acid biosynthesis" EXACT [] is_a: UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00404 name: L-lysine biosynthesis namespace: pathway def: "This pathway represents the biosynthesis of the basic amino-acid L-lysine. L-lysine biosynthesis is peculiar because it has two different anabolic routes that evolved separately in organisms, the diaminopimelate (DAP) and aminoadipate (AAA) pathways. The DAP pathway synthesizes L-lysine from aspartate and pyruvate, and diaminopimelate is an intermediate. The DAP pathway is utilised by most bacteria, some archaea, some fungi, some algae, and plants. The AAA pathway synthesizes L-lysine from 2-oxoglutarate (alpha-ketoglutarate) and acetyl coenzyme A (acetyl-CoA), and L-alpha-aminoadipate is an intermediate. The AAA pathway is utilised by most fungi, some algae, the bacterium Thermus thermophilus, and probably some archaea, such as Sulfolobus, Thermoproteus, and Pyrococcus [source: InterPro]. No organism is known to possess both pathways [PMID:20418392]. L-lysine is one of the 10 essential amino-acids that mammals are unable to synthesize, and must therefore acquire in their diets." [UPa:amorgat] synonym: "2,6-diaminohexanoic acid biosynthesis" EXACT [] synonym: "L-2,6-diaminohexanoate biosynthesis" EXACT [] xref: GO:0009085 "biological_process:lysine biosynthetic process" xref: PMID:12355264 xref: PMID:20418392 is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis [Term] id: UPa:UPA00405 name: myo-inositol degradation namespace: pathway def: "degradation of myo-inositol, one of nine distinct isomers of inositol." [UPa:amorgat] synonym: "cis-1,2,3,5-trans-4,6-cyclohexanehexol degradation" EXACT [] synonym: "myo-inositol catabolism" EXACT [] xref: GO:0019310 "biological_process:inositol catabolic process" is_a: UPa:UPA00614 ! polyol degradation [Term] id: UPa:UPA00406 name: nonprotein amino-acid biosynthesis namespace: pathway def: "The chemical reactions and pathways resulting in the formation of any amino-acid that does not normally occur as a constituent residue of proteins [source: GO]." [UPa:amorgat] is_a: UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00407 name: ureide metabolism namespace: pathway def: "The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants. [source: GO]." [UPa:amorgat] xref: GO:0010135 "biological_process:ureide metabolic process" is_a: UPa:UPA00045 ! nitrogen metabolism [Term] id: UPa:UPA00408 name: ketone metabolism namespace: pathway def: "The chemical reactions and physical changes involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [UPa:amorgat] xref: GO:0042180 "biological_process:cellular ketone metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00409 name: ketone biosynthesis namespace: pathway def: "The formation from simpler components of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [UPa:amorgat] xref: GO:0042181 "biological_process:ketone biosynthetic process" is_a: UPa:UPA00408 ! ketone metabolism [Term] id: UPa:UPA00410 name: ketone degradation namespace: pathway def: "The degradation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [UPa:amorgat] xref: GO:0042182 "biological_process:ketone catabolic process" is_a: UPa:UPA00408 ! ketone metabolism [Term] id: UPa:UPA00411 name: carbohydrate metabolism namespace: pathway def: "Metabolism of carbohydrates. Carbohydrates are essential structural component of living cells and source of energy. They include simple sugars with small molecules as well as macromolecular substances. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. Carbohydrates are classified according to the number of monosaccharide groups they contain." [UPa:amorgat] synonym: "saccharide metabolism" EXACT [] synonym: "sugar metabolism" EXACT [] xref: GO:0005975 "biological_process:carbohydrate metabolic process" is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00412 name: carbohydrate biosynthesis namespace: pathway def: "The formation from simpler components of carbohydrates. Carbohydrates are essential structural component of living cells and source of energy. They include simple sugars with small molecules as well as macromolecular substances. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. Carbohydrates are classified according to the number of monosaccharide groups they contain." [UPa:amorgat] synonym: "saccharide biosynthesis" EXACT [] synonym: "sugar biosynthesis" EXACT [] xref: GO:0016051 "biological_process:carbohydrate biosynthetic process" is_a: UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00413 name: carbohydrate degradation namespace: pathway def: "The degradation into simpler components of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [UPa:amorgat] xref: GO:0016052 "biological_process:carbohydrate catabolic process" is_a: UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00414 name: alkaloid metabolism namespace: pathway def: "Metabolism of alkaloids, a group of nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino-acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). Alkaloids are usually found in plants. Various alkaloids have toxic or medical properties, such as caffeine, morphine and nicotine." [UPa:amorgat] xref: GO:0009820 "biological_process:alkaloid metabolic process" is_a: UPa:UPA00045 ! nitrogen metabolism [Term] id: UPa:UPA00415 name: metabolic intermediate biosynthesis namespace: pathway def: "The formation from simpler components of compounds acting as metabolic intermediates." [UPa:amorgat] is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00416 name: isoprenoid biosynthesis namespace: pathway def: "The formation from simpler components of isoprene derivatives. Isoprene is the chemical 2-methyl-1,3-butadiene. It is a common structural motif in biological systems. The terpenes (for example, the carotenes are tetraterpenes) are derived from isoprene, as are the terpenoids and coenzyme Q. Also derived from isoprene are phytol, retinol (vitamin A) , tocopherol (vitamin E), dolichols, and squalene. Heme A has an isoprenoid tail, and lanosterol, the sterol precursor in animals, is derived from squalene and hence from isoprene. The functional isoprene units in biological systems are dimethylallyl pyrophosphate (DMAPP) and its isomer isopentenyl pyrophosphate (IPP), which are used in the biosynthesis of terpenes and lanosterol derivatives." [UPa:amorgat] xref: GO:0008299 "biological_process:isoprenoid biosynthetic process" is_a: UPa:UPA00415 ! metabolic intermediate biosynthesis is_a: UPa:UPA00420 ! lipid biosynthesis is_a: UPa:UPA00913 ! isoprenoid metabolism [Term] id: UPa:UPA00417 name: isopentenyl diphosphate biosynthesis namespace: pathway def: "Biosynthesis of isopentenyl-PP (isopentenyl diphosphate, IPP), the central intermediate in the biosynthesis of terpenoids (isoprenoids) Despite their diversity, all isoprenoids are derived from two universal five-carbon precursors: isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP). Two distinct routes of IPP biosynthesis occur in nature: the 'mevalonate pathway' and the recently discovered 'deoxyxylulose 5-phosphate (DXP) pathway'." [UPa:amorgat] synonym: "IDP biosynthesis" EXACT [] synonym: "IPP biosynthesis" EXACT [] synonym: "isopentenyl pyrophosphate biosynthesis" EXACT [] synonym: "isopentenyl-PP biosynthesis" EXACT [] xref: GO:0009240 "biological_process:isopentenyl diphosphate biosynthetic process" is_a: UPa:UPA00416 ! isoprenoid biosynthesis [Term] id: UPa:UPA00418 name: carotene biosynthesis namespace: pathway def: "Biosynthesis of carotene compounds, i.e carotenoids that do not contain oxygen." [UPa:amorgat] xref: GO:0016120 "biological_process:carotene biosynthetic process" is_a: UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00419 name: xantophyll biosynthesis namespace: pathway def: "Biosynthesis of xanthophylls (originally phylloxanthins), yellow pigments (oxycarotenoid type) from the carotenoid group." [UPa:amorgat] xref: GO:0016123 "biological_process:xanthophyll biosynthetic process" is_a: UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00420 name: lipid biosynthesis namespace: pathway def: "The formation from simpler components of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [UPa:amorgat] xref: GO:0008610 "biological_process:lipid biosynthetic process" is_a: UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00421 name: phytoalexin biosynthesis namespace: pathway def: "Biosynthesis of phytoalexins, a group of antibiotics produced by plants that are under attack. Phytoalexins tend to fall into several classes including terpenoids, glycosteroids and alkaloids. It is convenient to extend the definition to include all phytochemicals that are part of the plant's defensive arsenal. Phytoalexins produced in plants act as toxins to the attacking organism." [UPa:amorgat] xref: GO:0052315 "biological_process:phytoalexin biosynthetic process" is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00432 ! plant chemical defense is_a: UPa:UPA00476 ! toxin biosynthesis is_a: UPa:UPA00479 ! antifungal biosynthesis [Term] id: UPa:UPA00422 name: stilbenoid biosynthesis namespace: pathway def: "Biosynthesis of stilbenoids. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Chemically they are hydroxylated derivatives of stilbene." [UPa:amorgat] is_a: UPa:UPA00421 ! phytoalexin biosynthesis is_a: UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00423 name: terpene metabolism namespace: pathway def: "Metabolism of terpenes, a class of hydrocarbons produced by many plants, particularly conifers. Terpenes are major components of resin, and of turpentine produced from resin. The name 'terpene' comes from 'turpentine'. Terpenes are derived from isoprene C5H8 units and have the basic formula of multiples of it, i.e., (C5H8)n. The isoprene units can be arranged in a linear way or forming rings. One can consider isoprene as one of nature's preferred building blocks. Terpenes can be classified according to the number of isoprene units that they contain: * Monoterpenes, C10H16, 2 isoprene units * Sesquiterpenes, C15H24, 3 isoprene units * Diterpenes, C20H32, 4 isoprene units * Triterpenes, C30H48, 6 isoprene units * Tetraterpenes, C40H60, 8 isoprene units * Polyterpenes with a large number of isoprene units If terpenes are further modified, for instance by adding hydroxyl groups or moving or removing a methyl group, the resulting compounds are called terpenoids. (Some authors also call these compounds terpenes.) [wikipedia]." [UPa:amorgat] xref: GO:0042214 "biological_process:terpene metabolic process" is_a: UPa:UPA00325 ! hydrocarbon metabolism [Term] id: UPa:UPA00424 name: nucleotide biosynthesis namespace: pathway def: "The formation from simpler components of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [UPa:amorgat] xref: GO:0009165 "biological_process:nucleotide biosynthetic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00425 name: nucleoside biosynthesis namespace: pathway def: "Biosynthesis of nucleosides. Nucleosides are glycosylamines made by attaching a nucleobase (often referred to simply as bases) to a ribose or deoxyribose ring. In short, a nucleoside is a base linked to sugar." [UPa:amorgat] xref: GO:0009163 "biological_process:nucleoside biosynthetic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00426 name: energy metabolism namespace: pathway def: "The chemical reactions involved in energy transformations within cells." [UPa:amorgat] xref: GO:0006091 "biological_process:generation of precursor metabolites and energy" xref: GO:0006112 "biological_process:energy reserve metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00427 name: amino-acid degradation namespace: pathway def: "The breakdown into simpler components of amino-acids, organic acids containing one or more amino substituents." [UPa:amorgat] synonym: "amino-acid catabolism" EXACT [] xref: GO:0009063 "biological_process:cellular amino acid catabolic process" is_a: UPa:UPA00401 ! amino-acid metabolism [Term] id: UPa:UPA00428 name: lipid degradation namespace: pathway def: "Degradtion of lipids." [UPa:amorgat] xref: GO:0016042 "biological_process:lipid catabolic process" is_a: UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00429 name: L-arginine metabolism namespace: pathway def: "Metabolism of L-arginine, one of the 20 most common natural amino-acids." [UPa:amorgat] synonym: "2-amino-5-(diaminomethylidene amino)pentanoic acid metabolism" EXACT [] xref: GO:0006525 "biological_process:arginine metabolic process" is_a: UPa:UPA00401 ! amino-acid metabolism [Term] id: UPa:UPA00430 name: fatty acid degradation namespace: pathway def: "Degradation of fatty acids." [UPa:amorgat] xref: GO:0009062 "biological_process:fatty acid catabolic process" is_a: UPa:UPA00199 ! fatty acid metabolism is_a: UPa:UPA00428 ! lipid degradation [Term] id: UPa:UPA00431 name: Branched-chain amino-acid degradation namespace: pathway def: "Degradation of the branched-chain amino-acids leucine (Leu), isoleucine (Ile) and valine (Val)." [UPa:amorgat] xref: GO:0009083 "biological_process:branched-chain amino acid catabolic process" is_a: UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00432 name: plant chemical defense namespace: pathway def: "production of chemical defenses such as toxins against herbivores." [UPa:amorgat] is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00433 name: aromatic compound metabolism namespace: pathway def: "Metabolism of aromatic compounds." [UPa:amorgat] xref: GO:0006725 "biological_process:cellular aromatic compound metabolic process" is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00434 name: hormone metabolism namespace: pathway def: "Metabolism of hormone, a chemical messenger from one cell (or group of cells) to another. All multicellular organisms produce hormones (including plants, i.e phytohormone). The function of hormones is to serve as a signal to the target cells; the action of hormones is determined by the pattern of secretion and the signal transduction of the receiving tissue." [UPa:amorgat] xref: GO:0042445 "biological_process:hormone metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00435 name: hormone biosynthesis namespace: pathway def: "Biosynthesis of hormone, a chemical messenger from one cell (or group of cells) to another. Plant hormones pathways are described as phytohormone biosynthesis pathways." [UPa:amorgat] xref: GO:0042446 "biological_process:hormone biosynthetic process" is_a: UPa:UPA00434 ! hormone metabolism [Term] id: UPa:UPA00436 name: lipid metabolism namespace: pathway def: "Metabolism of lipid compounds." [UPa:amorgat] xref: GO:0006629 "biological_process:lipid metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00437 name: plant hormone metabolism namespace: pathway def: "Metabolism of plant hormones (plant growth regulators, PGRs, phytohormones). Plant hormones are internally-secreted chemicals in plants that are used for regulating the plant growth. According to a standard definition, plant hormones are signal molecules produced at specific locations, that occur in very low concentrations, and cause altered processes in target cells at other locations. It is accepted that there are five major classes of plant hormones: auxins, cytokinins(CK's), ethylene, gibberellins (GA's) and abscisic acid (ABA)." [UPa:amorgat] synonym: "PGR metabolism" EXACT [] synonym: "phytohormone metabolism" EXACT [] synonym: "plant growth regulator metabolism" EXACT [] is_a: UPa:UPA00434 ! hormone metabolism [Term] id: UPa:UPA00438 name: plant hormone biosynthesis namespace: pathway def: "Biosynthesis of plant hormones (plant growth regulators, PGRs, phytohormones)." [UPa:amorgat] synonym: "PGR biosynthesis" EXACT [] synonym: "phytohormone biosynthesis" EXACT [] synonym: "plant growth regulator biosynthesis" EXACT [] is_a: UPa:UPA00437 ! plant hormone metabolism [Term] id: UPa:UPA00439 name: plant hormone degradation namespace: pathway def: "degradation of plant hormones (plant growth regulators, PGRs, phytohormones)." [UPa:amorgat] synonym: "PGR degradation" EXACT [] synonym: "phytohormone degradation" EXACT [] synonym: "plant growth regulator degradation" EXACT [] is_a: UPa:UPA00437 ! plant hormone metabolism [Term] id: UPa:UPA00440 name: steroid hormone biosynthesis namespace: pathway def: "Biosynthesis of steroid hormones." [UPa:amorgat] is_a: UPa:UPA00062 ! steroid biosynthesis is_a: UPa:UPA00435 ! hormone biosynthesis [Term] id: UPa:UPA00441 name: glycan metabolism namespace: pathway def: "Metabolism of glycan polymers. The term glycan refers to a polysaccharide, or oligosaccharide. Glycan may also be used to refer to the carbohydrate portion of a glycoconjugate, such as a glycoprotein, glycolipid, or a proteoglycan." [UPa:amorgat] synonym: "oligosaccharide metabolism" EXACT [] synonym: "polysaccharide metabolism" EXACT [] xref: GO:0005976 "biological_process:polysaccharide metabolic process" is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00442 name: glycan degradation namespace: pathway def: "Degradation of glycan polymers. The term glycan refers to a polysaccharide, or oligosaccharide. Glycan may also be used to refer to the carbohydrate portion of a glycoconjugate, such as a glycoprotein, glycolipid, or a proteoglycan." [UPa:amorgat] synonym: "oligosaccharide degradation" EXACT [] synonym: "polysaccharide degradation" EXACT [] xref: GO:0000272 "biological_process:polysaccharide catabolic process" is_a: UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00443 name: trehalose metabolism namespace: pathway def: "Metabolism of trehalose (mycose), a disaccharide found extensively but not abundantly in nature. It can be synthesised by fungi, plants and invertebrate animals. It is implicated in anhydrobiosis - the ability of plants and animals to withstand prolonged periods of desiccation. Trehalose is the major carbohydrate energy storage molecule used by insects for flight." [UPa:amorgat] xref: GO:0005991 "biological_process:trehalose metabolic process" is_a: UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00444 name: glucan metabolism namespace: pathway def: "Metabolism of glucans, a group of polysaccharides of D-glucose monomers linked by glycosidic bonds." [UPa:amorgat] xref: GO:0006073 "biological_process:cellular glucan metabolic process" is_a: UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00445 name: one-carbon metabolism namespace: pathway def: "Metabolic pathways related to the flow of one-carbon units into cellular compounds." [UPa:amorgat] synonym: "1C unit metabolism" EXACT [] synonym: "C1 compound metabolism" EXACT [] xref: GO:0006730 "biological_process:one-carbon metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00446 name: alkaloid biosynthesis namespace: pathway def: "Biosynthesis of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases). [GO]." [UPa:amorgat] xref: GO:0009821 "biological_process:alkaloid biosynthetic process" is_a: UPa:UPA00414 ! alkaloid metabolism is_a: UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00447 name: alkaloid degradation namespace: pathway def: "Degradation of alkaloids." [UPa:amorgat] xref: GO:0009822 "biological_process:alkaloid catabolic process" is_a: UPa:UPA00414 ! alkaloid metabolism [Term] id: UPa:UPA00448 name: terpene biosynthesis namespace: pathway def: "The formation from simpler components of terpenes." [UPa:amorgat] xref: GO:0046246 "biological_process:terpene biosynthetic process" is_a: UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00449 name: sesquiterpene biosynthesis namespace: pathway def: "The formation from simpler components of sesquiterpenes. Sesquiterpenes are a class of terpenes that consist of three isoprene units and have the molecular formula C15H24. Like monoterpenes, sesquiterpenes may be acyclic or contain rings, including many unique combinations. Biochemical modifications such as oxidation or rearrangement produce the related sesquiterpenoids." [UPa:amorgat] synonym: "sesquiterpenoid biosynthesis" EXACT [] xref: GO:0051762 "biological_process:sesquiterpene biosynthetic process" is_a: UPa:UPA00448 ! terpene biosynthesis [Term] id: UPa:UPA00450 name: activated methyl cycle namespace: pathway def: "The activated methyl donor involved in most biosynthetic methylation is usually S-adenosylmethionine (SAM). SAM is synthesized by the transfer of an adenosyl group from ATP to the sulfur atom of methionine. The methyl group of the methionine unit is activated by the positive charge on the adjacent sulfur atom, which makes the molecule much more reactive than N5-methyltetrahydrofolate. The synthesis of S-adenosylmethionine is unusual in that the triphosphate group of ATP is split into pyrophosphate and orthophosphate; the pyrophosphate is subsequently hydrolyzed to two molecules of Pi. S-Adenosylhomocysteine is formed when the methyl group of S-adenosylmethionine is transferred to an acceptor. S-Adenosylhomocysteine is then hydrolyzed to homocysteine and adenosine. Methionine can be regenerated by the transfer of a methyl group to homocysteine. [Stryer, Biochemistry, 2002]." [UPa:amorgat] synonym: "S-adenosylmethionine cycle" EXACT [] synonym: "SAM cycle" EXACT [] xref: GO:0033353 {source="rdfmatch"} is_a: UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00451 name: lipopolysaccharide metabolism namespace: pathway def: "The chemical reactions involving lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [UPa:amorgat] xref: GO:0008653 "biological_process:lipopolysaccharide metabolic process" is_a: UPa:UPA00316 ! biopolymer metabolism relationship: uniprot_super_pathway UPa:UPA00324 ! bacterial outer membrane biogenesis [Term] id: UPa:UPA00452 name: lipopolysaccharide degradation namespace: pathway def: "Degradation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane." [UPa:amorgat] synonym: "lipopolysaccharide catabolism" EXACT [] xref: GO:0009104 "biological_process:lipopolysaccharide catabolic process" is_a: UPa:UPA00451 ! lipopolysaccharide metabolism [Term] id: UPa:UPA00453 name: GDP-L-fucose biosynthesis namespace: pathway def: "Biosynthesis of GDP-L-fucose from GDP-D-mannose. GDP-L-fucose is the substrate of fucosyltransferases for addition of fucose to polysaccharides or glycoproteins in both procaryotes and eucaryotes. In mammals, the biosynthesis of GDP-L-fucose consists of two pathways, namely salvage and de novo pathways." [UPa:amorgat] synonym: "GDP-D-mannose to GDP-L-fucose conversion" EXACT [] synonym: "GDP-L-fucose de novo pathway" EXACT [] xref: GO:0042350 "biological_process:GDP-L-fucose biosynthetic process" is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00454 name: oligopeptide biosynthesis namespace: pathway def: "Biosynthesis of oligopeptides." [UPa:amorgat] synonym: "peptide biosynthesis" EXACT [] xref: GO:0043043 {source="rdfmatch"} is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00455 name: amine and polyamine metabolism namespace: pathway def: "Metabolism of amines and polyamines. These compounds play a variety of roles in metabolism, including acting as osmoprotectants, keeping DNA in a condensed state, and serving as intermediates in the synthesis of macromolecules. The polyamines, e.g. 1,3-diaminopropane, putrescine, cadaverine, agmatine, spermidine and spermine, are wide-spread in all organisms, and have been shown to play a role in the regulation of growth and differentiation of virtually all types of cells." [UPa:amorgat] xref: GO:0006595 "biological_process:polyamine metabolic process" xref: GO:0009308 "biological_process:amine metabolic process" xref: PMID:12641342 xref: PMID:12927050 is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00456 name: amine and polyamine degradation namespace: pathway def: "Degradation of amines and polyamines." [UPa:amorgat] xref: GO:0006598 "biological_process:polyamine catabolic process" xref: GO:0009310 "biological_process:amine catabolic process" is_a: UPa:UPA00455 ! amine and polyamine metabolism [Term] id: UPa:UPA00457 name: putrescine metabolism namespace: pathway def: "Metabolism of putrescine, 1,4-diaminobutane. Putrescine is one of polyamines that are found in a wide range of organisms from bacteria to plants and animals, especially when these cells are proliferating or under stressful conditions (Tabor & Tabor, 1984). Polyamines can modulate the functions of RNA, DNA, nucleotide triphosphates, proteins, and other acidic substances, and they contribute to stimulate cell growth and viability (Igarashi & Kashiwagi, 2000). Putrescine is the metabolic precursor of spermidine and spermine." [UPa:amorgat] xref: GO:0009445 "biological_process:putrescine metabolic process" is_a: UPa:UPA00455 ! amine and polyamine metabolism [Term] id: UPa:UPA00458 name: protein biosynthesis namespace: pathway def: "Biosynthesis of proteins." [UPa:amorgat] xref: GO:0006412 "biological_process:translation" is_a: UPa:UPA00320 ! biopolymer biosynthesis is_a: UPa:UPA00467 ! protein metabolism [Term] id: UPa:UPA00459 name: pheromone biosynthesis namespace: pathway def: "Biosynthesis of pheromones. A pheromone is a chemical that triggers an innate behavioural response in another member of the same species. There are alarm pheromones, food trail pheromones, sex pheromones, and many others that affect behavior or physiology." [UPa:amorgat] xref: GO:0042811 "biological_process:pheromone biosynthetic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00460 name: protein modification namespace: pathway def: "Proteins are subjected to three classes of protein modifications, i.e. pre-, co- and post-translational modifications. A majority of modifications are made when the protein is already folded; these are genuine post-translational modifications (PTMs). Some modifications are made while the polypeptide is still being synthesized on the ribosome; these are co-translational modifications. A few 'non-standard' amino-acids are incorporated into proteins by modification of some 'standard' amino-acids while they are charged on special tRNAs; these are pre-translational modifications." [UPa:amorgat] xref: GO:0006464 "biological_process:cellular protein modification process" is_a: UPa:UPA00123 ! biopolymer modification is_a: UPa:UPA00467 ! protein metabolism [Term] id: UPa:UPA00461 name: post-translational protein modification namespace: pathway def: "Post-translation modifications are defined as 'series of chemical reactions whereby a newly synthesized polypeptide chain is converted to a functional protein. At the genetic point of view, any difference between a functional protein and the linear polypeptide sequence encoded between the initiation and the termination codons of its structural gene can be regarded as a post-translational modification of proteins. [This definition] restricts the meaning of post-translational modification to modifications that involve the making or breaking of covalent bonds.' (Han K.-K., Martinage A., 1992)." [UPa:amorgat] xref: GO:0043687 "biological_process:post-translational protein modification" is_a: UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00462 name: small protein conjugation namespace: pathway def: "Protein modification by small protein conjugation is a process by which one or more moieties of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein [source: GO]." [UPa:amorgat] xref: GO:0032446 "biological_process:protein modification by small protein conjugation" is_a: UPa:UPA00461 ! post-translational protein modification [Term] id: UPa:UPA00463 name: L-arabinose degradation namespace: pathway def: "Degradation of L-arabinose Degradation of L-arabinose, a major constituent of plant material. Bacteria and fungi can utilize this pentose sugar via different pathways. Two distinct pathways convert L-arabinose to D-xylulose 5-phosphate via L-ribulose (in bacteria) or via L-arabitol (in fungal). An additional pathway has been recently discovered in bacteria (A. brasiliense, H. seropedicae, P. saccharophila, S. meliloti). In this pathway, L-arabinose is oxidized to L-arabino-gamma-lactone." [UPa:amorgat] xref: GO:0019572 "biological_process:L-arabinose catabolic process" is_a: UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA00464 name: secondary metabolite biosynthesis namespace: pathway def: "The formation from simpler components of secondary metabolites." [UPa:amorgat] xref: GO:0044550 {source="rdfmatch"} is_a: UPa:UPA00465 ! secondary metabolite metabolism [Term] id: UPa:UPA00465 name: secondary metabolite metabolism namespace: pathway def: "Metabolism of secondary metabolites. Secondary metabolites are those chemical compounds in organisms that are not directly involved in the normal growth, development or reproduction of organisms. Typically primary metabolites are found across all species within broad phylogenetic groupings, and are produced using the same pathway (or nearly the same pathway) in all these species. Secondary metabolites, by contrast, are often species- specific (or found in only a small set of species in a narrow phylogenetic group), and without these compounds the organism suffers from only a mild impairment, lowered survivability/fecundity, aesthetic differences, or else no change in phenotype at all [http://en.wikipedia.org/wiki/Secondary_metabolite]." [UPa:amorgat] xref: GO:0019748 {source="rdfmatch"} is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00466 name: biopolymer degradation namespace: pathway def: "The chemical reactions and pathways resulting in the breakdown of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins [source: GO]." [UPa:amorgat] xref: GO:0009057 "biological_process:macromolecule catabolic process" is_a: UPa:UPA00316 ! biopolymer metabolism [Term] id: UPa:UPA00467 name: protein metabolism namespace: pathway def: "Metabolic pathways involving a specific protein as substrate." [UPa:amorgat] xref: GO:0044267 "biological_process:cellular protein metabolic process" is_a: UPa:UPA00316 ! biopolymer metabolism [Term] id: UPa:UPA00468 name: protein degradation namespace: pathway def: "Degradation of cellular proteins." [UPa:amorgat] synonym: "proteolysis" EXACT [] xref: GO:0044257 "biological_process:cellular protein catabolic process" is_a: UPa:UPA00466 ! biopolymer degradation is_a: UPa:UPA00467 ! protein metabolism [Term] id: UPa:UPA00469 name: lincosamide biosynthesis namespace: pathway def: "Biosynthesis of lincosamide group of antibiotics." [UPa:amorgat] is_a: UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00470 name: lantibiotic biosynthesis namespace: pathway def: "Biosynthesis of lantibiotics, a group of antimicrobial peptides synthesized by Gram- positive bacteria. Due to their difference in structure, two types of lantibiotics are distinguished, type A and type B lantibiotics." [UPa:amorgat] synonym: "lantibiotics biosynthesis" EXACT [] is_a: UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00471 name: lantibiotic A biosynthesis namespace: pathway def: "Biosynthesis of lantibiotics A. Type A lantibiotics are elongated, flexible peptides that act by forming pores in bacterial membrane." [UPa:amorgat] synonym: "lantibiotics A biosynthesis" EXACT [] is_a: UPa:UPA00470 ! lantibiotic biosynthesis [Term] id: UPa:UPA00472 name: lantibiotic B biosynthesis namespace: pathway def: "Biosynthesis of lantibiotics B. Type B lantibiotics are rigid, globular peptides with no net charge or a negative net charge. The type B comprise mersacidin, actagardin, and the cinnamycin group of peptides." [UPa:amorgat] synonym: "lantibiotics B biosynthesis" EXACT [] is_a: UPa:UPA00470 ! lantibiotic biosynthesis [Term] id: UPa:UPA00473 name: polyketide biosynthesis namespace: pathway def: "Biosynthesis of polyketides, a large group of complex natural products produced mainly by species of Streptomyces and related filamentous bacteria that include antibacterial, antifungal, anticancer, antiparasitic and immunosuppressant compounds. Despite their structures being strikingly diverse, they share a common pattern of biosynthesis in which simple carboxylic acid units are condensed onto the growing chain by a polyketide synthase (PKS) in a process resembling fatty acid biosynthesis." [UPa:amorgat] xref: GO:0030639 "biological_process:polyketide biosynthetic process" xref: PMID:2088174 xref: PMID:8257119 is_a: UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00474 name: penicillin biosynthesis namespace: pathway def: "Biosynthesis of penicillin (sometimes abbreviated PCN), a group of beta- lactam antibiotics used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms." [UPa:amorgat] synonym: "PCN biosynthesis" EXACT [] synonym: "penam biosynthesis" EXACT [] xref: GO:0042318 "biological_process:penicillin biosynthetic process" is_a: UPa:UPA00169 ! beta-lactam biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00475 name: cephalosporin biosynthesis namespace: pathway def: "Biosynthesis of cephalosporins, a class of beta-lactam antibiotics. Together with cephamycins they belong to a sub-group called cephems. Cephalosporins are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin binding proteins (PBPs)." [UPa:amorgat] xref: GO:0043646 "biological_process:cephalosporin biosynthetic process" xref: PMID:15719551 xref: PMID:15719553 is_a: UPa:UPA00169 ! beta-lactam biosynthesis [Term] id: UPa:UPA00476 name: toxin biosynthesis namespace: pathway def: "Biosynthesis of toxins." [UPa:amorgat] xref: GO:0009403 "biological_process:toxin biosynthetic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00477 name: phytotoxin biosynthesis namespace: pathway def: "Biosynthesis of phytotoxins." [UPa:amorgat] is_a: UPa:UPA00476 ! toxin biosynthesis [Term] id: UPa:UPA00478 name: mycotoxin biosynthesis namespace: pathway def: "Biosynthesis of mycotoxins, a group of toxins produced by fungus (mushrooms, molds and yeasts)." [UPa:amorgat] xref: GO:0043386 "biological_process:mycotoxin biosynthetic process" is_a: UPa:UPA00476 ! toxin biosynthesis [Term] id: UPa:UPA00479 name: antifungal biosynthesis namespace: pathway def: "Biosynthesis of antifungal compounds." [UPa:amorgat] is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00480 name: RNA modification namespace: pathway def: "RNA modification processes." [UPa:amorgat] xref: GO:0009451 "biological_process:RNA modification" is_a: UPa:UPA00123 ! biopolymer modification [Term] id: UPa:UPA00481 name: tRNA modification namespace: pathway def: "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically [source: GO]. Transfer RNA (tRNA) is structurally unique among nucleic acids in harboring an astonishing diversity of post-transcriptionally modified nucleoside. Over 80 modified nucleosides have been characterized. The nature of nucleoside modification varies from simple methylation to extensive 'hypermodification' of the canonical bases. Two of the most radically modified nucleosides known to occur in tRNA are queuosine and archaeosine, both of which are characterized by a 7-deazaguanosine core structure." [UPa:amorgat] synonym: "transfer RNA modification" EXACT [] xref: GO:0006400 "biological_process:tRNA modification" xref: PMID:12697167 is_a: UPa:UPA00480 ! RNA modification [Term] id: UPa:UPA00482 name: tRNA post-transcriptional modification namespace: pathway def: "Post-transcriptional modification of tRNA molecules." [UPa:amorgat] is_a: UPa:UPA00481 ! tRNA modification [Term] id: UPa:UPA00483 name: cofactor degradation namespace: pathway def: "Pathways involved in the degradation of cofactors." [UPa:amorgat] xref: GO:0051187 "biological_process:cofactor catabolic process" is_a: UPa:UPA00398 ! cofactor metabolism [Term] id: UPa:UPA00484 name: glycan biosynthesis namespace: pathway def: "Biosynthesis of glycan (polysaccharide) polymers. Glycan may also be used to refer to the carbohydrate portion of a glycoconjugate, such as a glycoprotein or a proteoglycan. Glycans usually consist solely of O-glycosidic linkages of monosaccharides (cellulose is a glycan composed of beta-1,4-linked D-glucose; chitin is a glycan composed of beta-1,4-linked N-acetyl-D-glucosamine). Glycans can be homo or heteropolymers of monosaccharide residues, and can be linear or branched." [UPa:amorgat] synonym: "polysaccharide biosynthesis" EXACT [] xref: GO:0000271 "biological_process:polysaccharide biosynthetic process" is_a: UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00485 name: genetic information processing namespace: pathway def: "Processing of genetic information." [UPa:amorgat] is_a: UPa:UPA00001 ! biological process [Term] id: UPa:UPA00486 name: nucleotide metabolism namespace: pathway def: "Metabolism of nucleotides." [UPa:amorgat] xref: GO:0009117 "biological_process:nucleotide metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00487 name: polyester biosynthesis namespace: pathway def: "Biosynthesis of polyester, a category of polymers which contain the ester functional group in their main chain." [UPa:amorgat] is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00488 name: purine nucleotide biosynthesis namespace: pathway def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety [source: GO]." [UPa:amorgat] xref: GO:0006164 "biological_process:purine nucleotide biosynthetic process" is_a: UPa:UPA00210 ! purine nucleotide metabolism is_a: UPa:UPA00584 ! purine biosynthesis relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00489 name: alanine metabolism namespace: pathway def: "Metabolism of (DL)-alanine, one of the major amino-acids present in proteins. Alanine can be used in the biosynthesis of the amino-acid valine and of the vitamin biotin, and both the L and D stereoisomers of alanine are major constituents of the peptidoglycan layer." [UPa:amorgat] synonym: "(DL)-alanine metabolism" EXACT [] xref: GO:0006522 "biological_process:alanine metabolic process" is_a: UPa:UPA00401 ! amino-acid metabolism [Term] id: UPa:UPA00490 name: histidine metabolism namespace: pathway def: "Metabolism of (DL)-histidine amino-acid." [UPa:amorgat] synonym: "(DL)-histidine metabolism" EXACT [] xref: GO:0006547 "biological_process:histidine metabolic process" is_a: UPa:UPA00401 ! amino-acid metabolism [Term] id: UPa:UPA00491 name: alanine degradation namespace: pathway def: "Degradation of (DL)-alanine amino-acid." [UPa:amorgat] synonym: "(DL)-alanine degradation" EXACT [] xref: GO:0006524 "biological_process:alanine catabolic process" is_a: UPa:UPA00427 ! amino-acid degradation is_a: UPa:UPA00489 ! alanine metabolism [Term] id: UPa:UPA00492 name: L-histidine degradation namespace: pathway def: "Degradation of L-histidine amino-acid." [UPa:amorgat] synonym: "2-amino-3-(1H-imidazol-4-yl)propanoate degradation" EXACT [] synonym: "2-amino-3-(1H-imidazol-4-yl)propanoic acid degradation" EXACT [] xref: GO:0006548 "biological_process:histidine catabolic process" is_a: UPa:UPA00427 ! amino-acid degradation is_a: UPa:UPA00490 ! histidine metabolism [Term] id: UPa:UPA00493 name: L-threonine degradation namespace: pathway def: "Degradation of L-threonine amino-acid." [UPa:amorgat] synonym: "2-amino-3-hydroxybutanoate degradation" EXACT [] synonym: "2-amino-3-hydroxybutyric acid degradation" EXACT [] xref: GO:0006567 "biological_process:threonine catabolic process" is_a: UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00494 name: glycerolipid degradation namespace: pathway def: "Degradation of glycerolipids." [UPa:amorgat] xref: GO:0046503 "biological_process:glycerolipid catabolic process" is_a: UPa:UPA00230 ! glycerolipid metabolism [Term] id: UPa:UPA00495 name: glycerolipid biosynthesis namespace: pathway def: "Biosynthesis of glycerolipids." [UPa:amorgat] xref: GO:0045017 "biological_process:glycerolipid biosynthetic process" is_a: UPa:UPA00230 ! glycerolipid metabolism is_a: UPa:UPA00420 ! lipid biosynthesis [Term] id: UPa:UPA00496 name: metabolic intermediate metabolism namespace: pathway def: "Metabolism of metabolic intermediate compounds." [UPa:amorgat] is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00497 name: (R)-mevalonate metabolism namespace: pathway def: "Metabolism of (R)-mevalonate, a key organic compound in biochemistry. (R)-mevalonate is a precursor of terpenes and steroids." [UPa:amorgat] synonym: "mevalonate metabolism" EXACT [] is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00498 name: metabolic intermediate degradation namespace: pathway def: "Degradation of metabolic intermediate compounds." [UPa:amorgat] is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00499 name: pigment biosynthesis namespace: pathway def: "Biosynthesis of pigments." [UPa:amorgat] xref: GO:0046148 "biological_process:pigment biosynthetic process" is_a: UPa:UPA00672 ! pigment metabolism [Term] id: UPa:UPA00500 name: Lipooligosaccharide metabolism namespace: pathway def: "Metabolism of lipooligosaccharide." [UPa:amorgat] xref: GO:1901269 {source="rdfmatch"} is_a: UPa:UPA00324 ! bacterial outer membrane biogenesis is_a: UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00501 name: lipooligosaccharide biosynthesis namespace: pathway def: "Biosynthesis of lipooligosaccharide (LOS), an important amphiphilic molecule integrated in and extending outward from the outer membrane of some bacterial cell wall (Neisseria and Haemophilus sp). LOS is similar to lipopolysaccharide (LPS) but lacking the O-antigen polysaccharide side chain repeats. LOS comprises two parts: i) core oligosaccharide and ii) lipid A." [UPa:amorgat] synonym: "LOS biosynthesis" EXACT [] xref: PMID:11521077 is_a: UPa:UPA00500 ! Lipooligosaccharide metabolism is_a: UPa:UPA00938 ! membrane lipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00324 ! bacterial outer membrane biogenesis [Term] id: UPa:UPA00502 name: alginate metabolism namespace: pathway def: "Metabolism of alginate, a polyssacharide produced by brown seaweeds an some bacteria." [UPa:amorgat] xref: GO:0042120 "biological_process:alginic acid metabolic process" is_a: UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00503 name: choline metabolism namespace: pathway def: "Metabolism of choline (bilineurine)." [UPa:amorgat] synonym: "bilineurine metabolism" EXACT [] xref: GO:0019695 "biological_process:choline metabolic process" is_a: UPa:UPA00455 ! amine and polyamine metabolism [Term] id: UPa:UPA00504 name: steroid metabolism namespace: pathway def: "Metabolism of steroids. A steroid is a terpenoid lipid characterized by a carbon skeleton with four fused rings, derived from the cyclization of the triterpene squalene. Different steroids vary in the functional groups attached to these rings." [UPa:amorgat] xref: GO:0008202 "biological_process:steroid metabolic process" is_a: UPa:UPA00423 ! terpene metabolism is_a: UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00505 name: glycolipid metabolism namespace: pathway def: "Metabolism of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid." [UPa:amorgat] xref: GO:0006664 "biological_process:glycolipid metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00506 name: glycolipid biosynthesis namespace: pathway def: "Biosynthesis of glycolipids (e.g glycosylphosphatidylinositol)." [UPa:amorgat] xref: GO:0009247 "biological_process:glycolipid biosynthetic process" is_a: UPa:UPA00505 ! glycolipid metabolism [Term] id: UPa:UPA00507 name: tropane alkaloid metabolism namespace: pathway def: "The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system [source: GO]." [UPa:amorgat] xref: GO:0046448 "biological_process:tropane alkaloid metabolic process" is_a: UPa:UPA00414 ! alkaloid metabolism [Term] id: UPa:UPA00508 name: tropane alkaloid degradation namespace: pathway def: "Degradation of tropan alkaloids." [UPa:amorgat] is_a: UPa:UPA00447 ! alkaloid degradation is_a: UPa:UPA00507 ! tropane alkaloid metabolism [Term] id: UPa:UPA00509 name: isoquinoline alkaloid metabolism namespace: pathway def: "Metabolism of isoquinoline alkaloids." [UPa:amorgat] xref: GO:0033076 {source="rdfmatch"} is_a: UPa:UPA00414 ! alkaloid metabolism [Term] id: UPa:UPA00510 name: isoquinoline alkaloid biosynthesis namespace: pathway def: "Biosynthesis of isoquinoline alkaloids." [UPa:amorgat] xref: GO:0033075 "biological_process:isoquinoline alkaloid biosynthetic process" is_a: UPa:UPA00446 ! alkaloid biosynthesis is_a: UPa:UPA00509 ! isoquinoline alkaloid metabolism [Term] id: UPa:UPA00511 name: terpenoid indole alkaloid metabolism namespace: pathway def: "Metabolism of terpenoid indole alkaloids." [UPa:amorgat] xref: GO:0046447 "biological_process:terpenoid indole alkaloid metabolic process" is_a: UPa:UPA00414 ! alkaloid metabolism is_a: UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00512 name: terpenoid indole alkaloid biosynthesis namespace: pathway def: "Biosynthesis of terpenoid indole alkaloids." [UPa:amorgat] xref: GO:0009709 "biological_process:terpenoid indole alkaloid biosynthetic process" xref: PMID:16874388 is_a: UPa:UPA00446 ! alkaloid biosynthesis is_a: UPa:UPA00448 ! terpene biosynthesis is_a: UPa:UPA00511 ! terpenoid indole alkaloid metabolism [Term] id: UPa:UPA00513 name: pyrimidine nucleotide biosynthesis namespace: pathway def: "Biosynthesis of pyrimidine nucleotides." [UPa:amorgat] xref: GO:0006221 "biological_process:pyrimidine nucleotide biosynthetic process" is_a: UPa:UPA00313 ! pyrimidine nucleotide metabolism is_a: UPa:UPA00424 ! nucleotide biosynthesis is_a: UPa:UPA00571 ! pyrimidine biosynthesis [Term] id: UPa:UPA00514 name: isoquinoline alkaloid degradation namespace: pathway def: "Biosynthesis of isoquinoline alkaloids." [UPa:amorgat] xref: GO:0071274 {source="rdfmatch"} is_a: UPa:UPA00447 ! alkaloid degradation is_a: UPa:UPA00509 ! isoquinoline alkaloid metabolism [Term] id: UPa:UPA00515 name: carbon fixation namespace: pathway def: "Carbon fixation is a process found in autotrophs, usually driven by photosynthesis, whereby carbon dioxide (CO(2)) is converted into organic compounds. There are three types of carbon fixation pathways: i) C3 acid cycle; ii) C4 acid cycle; iii) CAM pathway." [UPa:amorgat] synonym: "CO2 fixation" EXACT [] xref: GO:0015977 "biological_process:carbon fixation" is_a: UPa:UPA00091 ! photosynthesis [Term] id: UPa:UPA00516 name: protein maturation namespace: pathway def: "Protein maturation process." [UPa:amorgat] xref: GO:0051604 "biological_process:protein maturation" is_a: UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00517 name: hydrogenase maturation namespace: pathway def: "Protein maturation via an hydrogenase process." [UPa:amorgat] is_a: UPa:UPA00516 ! protein maturation [Term] id: UPa:UPA00518 name: hopanoid metabolism namespace: pathway def: "Metabolism of hopanoids, a group of pentacyclic compounds similar to sterols, whose primary function is to improve plasma membrane fluidity in prokaryotes. Cholesterol serves a similar function in eukaryotes (including humans)." [UPa:amorgat] xref: GO:0019744 "biological_process:hopanoid metabolic process" is_a: UPa:UPA00465 ! secondary metabolite metabolism is_a: UPa:UPA00504 ! steroid metabolism [Term] id: UPa:UPA00519 name: hyaluronan metabolism namespace: pathway def: "Metabolism of hyaluronan (hyaluronic acid), a glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is one of the major components of the extracellular matrix and thereby contributes significantly to cell proliferation and migration. It may be involved in the progression of some malignant tumors." [UPa:amorgat] synonym: "hyaluronate metabolism" EXACT [] synonym: "hyaluronic acid metabolism" EXACT [] xref: GO:0030212 "biological_process:hyaluronan metabolic process" is_a: UPa:UPA00860 ! glycosaminoglycan metabolism [Term] id: UPa:UPA00520 name: organosulfur metabolism namespace: pathway def: "Metabolism of organosulfurs, organic compounds that contain sulfur." [UPa:amorgat] is_a: UPa:UPA00096 ! sulfur metabolism [Term] id: UPa:UPA00521 name: organosulfur biosynthesis namespace: pathway def: "Biosynthesis of organosulfurs, organic compounds that contain sulfur." [UPa:amorgat] is_a: UPa:UPA00520 ! organosulfur metabolism [Term] id: UPa:UPA00522 name: organosulfur degradation namespace: pathway def: "Degradation of organosulfurs, organic compounds that contain sulfur." [UPa:amorgat] is_a: UPa:UPA00520 ! organosulfur metabolism [Term] id: UPa:UPA00523 name: heterocycle metabolism namespace: pathway def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings) [source: GO]." [UPa:amorgat] xref: GO:0046483 "biological_process:heterocycle metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00524 name: purine base biosynthesis namespace: pathway def: "Biosynthesis of purine base, an heterocyclic aromatic organic compound found in DNA or RNA." [UPa:amorgat] xref: GO:0009113 "biological_process:purine nucleobase biosynthetic process" is_a: UPa:UPA00400 ! purine base metabolism is_a: UPa:UPA00584 ! purine biosynthesis [Term] id: UPa:UPA00525 name: aromatic amino-acid biosynthesis namespace: pathway def: "Biosynthesis of amino-acid with an aromatic side-chain: phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp)." [UPa:amorgat] xref: GO:0009073 "biological_process:aromatic amino acid family biosynthetic process" is_a: UPa:UPA00402 ! amino-acid biosynthesis is_a: UPa:UPA00754 ! aromatic compound biosynthesis [Term] id: UPa:UPA00526 name: L-tryptophan degradation namespace: pathway def: "Degradation of amino-acid L-tryptophan." [UPa:amorgat] synonym: "(S)-alpha-amino-beta-(3-indolyl)-propionic acid degradation" EXACT [] synonym: "2-amino-3-(1H-indol-3-yl)propanoic acid degradation" EXACT [] xref: GO:0006569 "biological_process:tryptophan catabolic process" is_a: UPa:UPA00224 ! tryptophan metabolism is_a: UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00527 name: L-alanine degradation via dehydrogenase pathway namespace: pathway def: "Hydrolysis of L-alanine to ammonia and pyruvate." [UPa:amorgat] xref: GO:0042853 "biological_process:L-alanine catabolic process" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00430 "Taurine and hypotaurine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:PWY1-2 is_a: UPa:UPA00491 ! alanine degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00528 name: L-alanine degradation via transaminase pathway namespace: pathway def: "Breakdown of alanine via an aminotransferase reaction (transfer of an amino group from glutamate to pyruvate to form 2-oxoglutarate and alanine)." [UPa:amorgat] xref: GO:0042853 "biological_process:L-alanine catabolic process" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00710 "Carbon fixation in photosynthetic organisms" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:17319845 is_a: UPa:UPA00491 ! alanine degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00529 name: betaine biosynthesis via choline pathway namespace: pathway def: "Biosynthesis of betaine (glycine betaine, N,N,N-trimethylglycine) by a two- step oxidation of choline. An alternative pathway converts glycine to betaine through two N-methyltransferases." [UPa:amorgat] xref: GO:0019285 "biological_process:glycine betaine biosynthetic process from choline" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: MetaCyc:BETSYN-PWY xref: MetaCyc:PWY-3722 xref: MetaCyc:PWY1F-353 xref: PMID:11685374 xref: PMID:12192001 xref: PMID:8752328 is_a: UPa:UPA00264 ! betaine biosynthesis is_a: UPa:UPA00503 ! choline metabolism relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00530 name: betaine biosynthesis via glycine pathway namespace: pathway def: "Biosynthesis of betaine (glycine betaine, N,N,N-trimethylglycine) by a three-step series of methylation reactions from glycine." [UPa:amorgat] xref: GO:0019286 "biological_process:glycine betaine biosynthetic process from glycine" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: MetaCyc:P541-PWY xref: PMID:10896953 xref: PMID:11319079 xref: PMID:12466265 xref: PMID:17019606 xref: PMID:17098399 is_a: UPa:UPA00264 ! betaine biosynthesis relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00531 name: L-proline metabolism namespace: pathway def: "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino-acid found in peptide linkage in proteins." [UPa:amorgat] synonym: "pyrrolidine-2-carboxylic acid metabolism" EXACT [] xref: GO:0006560 "biological_process:proline metabolic process" is_a: UPa:UPA00401 ! amino-acid metabolism [Term] id: UPa:UPA00532 name: L-proline degradation namespace: pathway def: "Degradation of L-proline (pyrrolidine-2-carboxylic acid) amino-acid." [UPa:amorgat] synonym: "pyrrolidine-2-carboxylic acid degradation" EXACT [] xref: GO:0006562 "biological_process:proline catabolic process" is_a: UPa:UPA00427 ! amino-acid degradation is_a: UPa:UPA00531 ! L-proline metabolism [Term] id: UPa:UPA00533 name: L-glutamate degradation via hydroxyglutarate pathway namespace: pathway def: "The hydroxyglutarate pathway is one of the major pathways by which L-glutamate amino-acid is fermented. This pathway is found in organisms living in anoxic niches within humans and animals, including members of the genus Acidaminococcus, Clostridium, Fusobacterium and Peptostreptococcus." [UPa:amorgat] synonym: "hydroxyglutarate pathway" EXACT [] synonym: "L-glutamate fermentation" EXACT [] xref: GO:0019552 "biological_process:glutamate catabolic process via 2-hydroxyglutarate" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map00362 "Benzoate degradation" xref: KEGG:map00471 "D-Glutamine and D-glutamate metabolism" xref: KEGG:map00650 "Butanoate metabolism" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:P162-PWY xref: PMID:11106419 is_a: UPa:UPA00351 ! L-glutamate degradation is_a: UPa:UPA00553 ! fermentation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00534 name: putrescine biosynthesis via agmatine pathway namespace: pathway def: "Agmatine, which results from the decarboxylation of L-arginine by arginine decarboxylase, is a metabolic intermediate in the biosynthesis of putrescine and higher polyamines (spermidine and spermine). Recent studies indicate that agmatine can have several important biochemical effects in humans, ranging from effects on the central nervous system to cell proliferation in cancer and viral replication." [UPa:amorgat] xref: GO:0033388 "biological_process:putrescine biosynthetic process from arginine" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:PWY-40 xref: MetaCyc:PWY-43 xref: PMID:11673419 xref: PMID:11804860 xref: PMID:12435743 xref: PMID:12634339 is_a: UPa:UPA00187 ! putrescine biosynthesis relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00535 name: putrescine biosynthesis via L-ornithine pathway namespace: pathway def: "The pathway for mammalian putrescine synthesis was demonstrated to occur via the decarboxylation of ornithine." [UPa:amorgat] xref: GO:0033387 "biological_process:putrescine biosynthetic process from ornithine" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map00480 "Glutathione metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: MetaCyc:PWY-46 xref: PMID:14763899 is_a: UPa:UPA00187 ! putrescine biosynthesis relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00536 name: protein lipoylation namespace: pathway def: "R-(+)-lipoic acid is a disulfide-containing cofactor widely distributed among living organisms. It is covalently attached to the E2 acyltransferase subunit of the pyruvate, alpha-ketoglutarate, and branched-chain alpha-ketoacid dehydrogenase complexes and to H-protein of the glycine cleavage system via an amide linkage between the carboxyl group of lipoic acid and the epsilon-amino group of a specific lysine residue of these proteins. Protein lipoylation can be achieved by two distinct pathways." [UPa:amorgat] xref: GO:0009249 "biological_process:protein lipoylation" is_a: UPa:UPA00516 ! protein maturation [Term] id: UPa:UPA00537 name: protein lipoylation via exogenous pathway namespace: pathway def: "Protein lipoylation via exogenous pathway." [UPa:amorgat] xref: KEGG:map00785 "Lipoic acid metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00536 ! protein lipoylation relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00538 name: protein lipoylation via endogenous pathway namespace: pathway def: "Protein lipoylation via endogenous pathway." [UPa:amorgat] xref: KEGG:map00785 "Lipoic acid metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00536 ! protein lipoylation relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00539 name: pyrroloquinoline quinone biosynthesis namespace: pathway def: "Biosynthesis of pyrroloquinoline quinone (PQQ, 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid), a bacterial vitamin that serves as a cofactor in numerous alcohol dehydrogenases. Its biosynthesis in Klebsiella pneumoniae is facilitated by six genes, pqqABCDEF, and proceeds by an unknown pathway." [UPa:amorgat] synonym: "4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid biosynthesis" EXACT [] synonym: "PQQ biosynthesis" EXACT [] xref: GO:0018189 "biological_process:pyrroloquinoline quinone biosynthetic process" is_a: UPa:UPA00829 ! quinol/quinone biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00540 name: oxalate degradation namespace: pathway def: "Degradation of oxalate. Because of its toxicity, oxalate accumulation from amino-acid catabolism leads to acute disorders in mammals. Gut microflora are therefore pivotal in maintaining a safe intestinal oxalate balance through oxalate degradation. Oxalate catabolism was first identified in Oxalobacter formigenes, a specialized, strictly anaerobic bacterium. Oxalate degradation was found to be performed successively by two enzymes, a formyl-CoA transferase (frc) and an oxalate decarboxylase (oxc). These two genes are present in several bacterial genomes including that of Escherichia coli." [UPa:amorgat] xref: GO:0033611 "biological_process:oxalate catabolic process" xref: KEGG:map00630 "Glyoxylate and dicarboxylate metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00498 ! metabolic intermediate degradation relationship: uniprot_super_pathway UPa:UPA00498 ! metabolic intermediate degradation [Term] id: UPa:UPA00541 name: L-rhamnose degradation namespace: pathway def: "Degradation of L-rhamnose (hexose 6-deoxy-L-mannose)." [UPa:amorgat] synonym: "hexose 6-deoxy-L-mannose degradation" EXACT [] xref: GO:0019301 "biological_process:rhamnose catabolic process" xref: KEGG:map00051 "Fructose and mannose metabolism" is_a: UPa:UPA00125 ! L-rhamnose metabolism is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA00542 name: lactose degradation namespace: pathway def: "Degradation of lactose, a disaccharide that consists of beta-D-galactose and beta-D-glucose molecules bonded through a beta-1-4 glycosidic linkage." [UPa:amorgat] synonym: "galactopyranosyl-glucose degradation" EXACT [] xref: GO:0005990 "biological_process:lactose catabolic process" xref: KEGG:map00052 "Galactose metabolism" xref: MetaCyc:LACTOSECAT-PWY is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00543 name: GDP-D-glycero-alpha-D-manno-heptose biosynthesis namespace: pathway def: "Biosynthesis of GDP-D-glycero-alpha-D-manno-heptose (GDP-D-beta-D-heptose), a nucleotide-sugar present in S-layer glycoproteins or capsular polysaccharide or flagella." [UPa:amorgat] xref: PMID:12101286 is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00544 name: peptidoglycan recycling namespace: pathway def: "Recycling of peptidoglycan, also known as murein, a polymer consisting of sugars and amino-acids that forms a mesh-like layer outside the plasma membrane of eubacteria." [UPa:amorgat] synonym: "murein recycling" EXACT [] xref: GO:0009254 "biological_process:peptidoglycan turnover" is_a: UPa:UPA00547 ! cell wall biogenesis relationship: uniprot_super_pathway UPa:UPA00547 ! cell wall biogenesis [Term] id: UPa:UPA00545 name: pectin degradation namespace: pathway def: "Degradation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [UPa:amorgat] synonym: "poly(1,4-alpha-D-galacturonide) degradation" EXACT [] xref: GO:0045490 "biological_process:pectin catabolic process" xref: KEGG:map00040 "Pentose and glucuronate interconversions" xref: KEGG:map00500 "Starch and sucrose metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00442 ! glycan degradation relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00546 name: cell wall metabolism namespace: pathway def: "Metabolism of cell wall components." [UPa:amorgat] xref: GO:0044036 "biological_process:cell wall macromolecule metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00547 name: cell wall biogenesis namespace: pathway def: "Biosynthesis of cell wall components." [UPa:amorgat] synonym: "cell wall biosynthesis" EXACT [] xref: GO:0042546 "biological_process:cell wall biogenesis" is_a: UPa:UPA00546 ! cell wall metabolism is_a: UPa:UPA00931 ! cellular component biogenesis [Term] id: UPa:UPA00548 name: cell wall degradation namespace: pathway def: "Degradation of cell wall components." [UPa:amorgat] xref: GO:0016998 "biological_process:cell wall macromolecule catabolic process" is_a: UPa:UPA00546 ! cell wall metabolism [Term] id: UPa:UPA00549 name: peptidoglycan degradation namespace: pathway def: "Degradation of peptidoglycan, also known as murein, a polymer consisting of sugars and amino-acids that forms a mesh-like layer outside the plasma membrane of eubacteria." [UPa:amorgat] synonym: "murein degradation" EXACT [] xref: GO:0016998 "biological_process:cell wall macromolecule catabolic process" is_a: UPa:UPA00548 ! cell wall degradation relationship: uniprot_super_pathway UPa:UPA00548 ! cell wall degradation [Term] id: UPa:UPA00550 name: thermoadapter biosynthesis namespace: pathway def: "Biosynthesis of thermoadapter, low molecular-weight compounds with thermoadaptive function (e.g cyclic 2,3-diphosphoglycerate)." [UPa:amorgat] is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00551 name: cyclic 2,3-diphosphoglycerate biosynthesis namespace: pathway def: "Biosynthesis of cyclic 2, 3-diphosphoglycerate (cDPG), a trianionic compound acting as thermoadapter in thermophile organisms." [UPa:amorgat] synonym: "cDPG biosynthesis" EXACT [] xref: GO:1901369 {source="rdfmatch"} xref: PMID:2226838 xref: PMID:8159166 xref: PMID:9811660 is_a: UPa:UPA00550 ! thermoadapter biosynthesis relationship: uniprot_super_pathway UPa:UPA00550 ! thermoadapter biosynthesis [Term] id: UPa:UPA00552 name: cytidine metabolism namespace: pathway def: "Metabolism of cytidine, a pyrimidine deoxynucleoside." [UPa:amorgat] xref: GO:0046108 "biological_process:uridine metabolic process" is_a: UPa:UPA00313 ! pyrimidine nucleotide metabolism [Term] id: UPa:UPA00553 name: fermentation namespace: pathway def: "Fermentation is the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, yielding energy in the form of adenosine triphosphate (ATP). [source: GO]." [UPa:amorgat] synonym: "anaerobic respiration" EXACT [] xref: GO:0006113 "biological_process:fermentation" is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00554 name: pyruvate fermentation to lactate namespace: pathway def: "Conversion of pyruvate (the final product of glycolysis) to lactate in the absence of oxygen." [UPa:amorgat] xref: KEGG:map00010 "Glycolysis / Gluconeogenesis" xref: KEGG:map00620 "Pyruvate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:PWY-5481 is_a: UPa:UPA00231 ! pyruvate metabolism is_a: UPa:UPA00498 ! metabolic intermediate degradation is_a: UPa:UPA00553 ! fermentation is_a: UPa:UPA00699 ! organic acid degradation relationship: uniprot_super_pathway UPa:UPA00553 ! fermentation [Term] id: UPa:UPA00555 name: cytochrome c assembly namespace: pathway def: "Bacterial c-type cytochromes are localized to the outside of the cytoplasmic membrane where they function in electron transport processes. Assembly takes place on the outside of the cytoplasmic membrane, involving separate transport of heme and the apocytochrome across the membrane [PMID:2172694]; the latter occurs via the general protein secretory (Sec) pathway of the cell [PMID:9219541]. Following translocation, assembly proceeds via a pathway involving a number of specific proteins. Two distinct systems have been identified in bacteria. System I is found in alpha - and gamma -proteobacteria, including E. coli, R. capsulatus, B. japonicum, and P. denitrificans. System II seems more widespread than system I, occurring in a range of bacteria including cyanobacteria, Gram-positive bacteria such as Mycobacterium species, beta -, gamma -, and delta -proteobacteria such as B. pertussis, T. ferrooxidans, and H. pylori, respectively, and some extremophiles such as A. aeoliticus. Common to both systems is that the apocytochrome cysteine thiols and the heme iron must be in their reduced states for thioether bond formation to occur. Thiol-disulfide oxidoreductases are required for this, and specific proteins have been identified in a number of system I organisms, including E. coli (CcmG), R. capsulatus (HelX), B. japonicum (CycY), and P. denitrificans (CcmG), and one system II organism, B. pertussis (CcsX) [PMID:12637552]." [UPa:amorgat] synonym: "c-type cytochrome assembly" EXACT [] xref: PMID:12637552 xref: PMID:2172694 xref: PMID:9219541 is_a: UPa:UPA00460 ! protein modification relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00556 name: lipoteichoic acid biosynthesis namespace: pathway def: "Biosynthesis of lipoteichoic acid (LTA), a glycerol phosphate surface polymer. Lipoteichoic acid is a component of the envelope of Gram-positive bacteria. This polyphosphoglycerol compound is substituted with a D-alanyl (D-Ala) ester or a glycosyl residue and is anchored in the membrane by its glycolipid moiety." [UPa:amorgat] synonym: "LTA biosynthesis" EXACT [] xref: GO:0070395 "biological_process:lipoteichoic acid biosynthetic process" xref: PMID:10781555 xref: PMID:11591677 xref: PMID:11849532 xref: PMID:16885447 xref: PMID:17434999 is_a: UPa:UPA00547 ! cell wall biogenesis relationship: uniprot_super_pathway UPa:UPA00547 ! cell wall biogenesis [Term] id: UPa:UPA00557 name: CDP-diacylglycerol biosynthesis namespace: pathway def: "Biosynthesis of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a molecule composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [UPa:amorgat] xref: GO:0016024 "biological_process:CDP-diacylglycerol biosynthetic process" xref: KEGG:map00561 "Glycerolipid metabolism" xref: KEGG:map00564 "Glycerophospholipid metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map04070 "Phosphatidylinositol signaling system" xref: MetaCyc:PHOSLIPSYN-PWY is_a: UPa:UPA00751 ! phospholipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00085 ! phospholipid metabolism [Term] id: UPa:UPA00558 name: phosphatidylethanolamine biosynthesis namespace: pathway def: "Biosynthesis of phosphatidylethanolamine compounds, any of a class of phospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [UPa:amorgat] xref: GO:0006646 "biological_process:phosphatidylethanolamine biosynthetic process" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00564 "Glycerophospholipid metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:PHOSLIPSYN-PWY is_a: UPa:UPA00751 ! phospholipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00085 ! phospholipid metabolism [Term] id: UPa:UPA00559 name: peptidyl-diphthamide biosynthesis namespace: pathway def: "The translation elongation factor 2 (eEF-2) in eukaryotes and some archaea contains a unique posttranslationally modified histidine residue, termed diphthamide, which serves as the only target for diphtheria toxin and Pseudomonas aeruginosa exotoxin A. The biosynthesis of diphthamide represents one of the most complex posttranslational modifications. The biosynthesis is accomplished by stepwise additions to the His715 (His699 in yeast) residue of eEF-2." [UPa:amorgat] synonym: "2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine biosynthesis" EXACT [] xref: GO:0017183 "biological_process:peptidyl-diphthamide biosynthetic process from peptidyl-histidine" xref: PMID:15485916 xref: PMID:16648478 xref: PMID:6402493 is_a: UPa:UPA00406 ! nonprotein amino-acid biosynthesis is_a: UPa:UPA00460 ! protein modification relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00560 name: ethanolamine degradation namespace: pathway def: "Degradation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [UPa:amorgat] synonym: "2-aminoethanol degradation" EXACT [] xref: GO:0046336 "biological_process:ethanolamine catabolic process" xref: PMID:16291677 is_a: UPa:UPA00456 ! amine and polyamine degradation is_a: UPa:UPA00612 ! alcohol degradation relationship: uniprot_super_pathway UPa:UPA00456 ! amine and polyamine degradation [Term] id: UPa:UPA00561 name: L-glutamate degradation via mesaconate pathway namespace: pathway def: "The mesaconate pathway is one of the major pathways by which L-glutamate amino-acid is fermented." [UPa:amorgat] synonym: "L-glutamate degradation via L-citramalate pathway" EXACT [] synonym: "L-glutamate degradation via methylaspartate pathway" EXACT [] synonym: "L-glutamate fermentation" EXACT [] xref: GO:0019553 "biological_process:glutamate catabolic process via L-citramalate" xref: KEGG:map00660 "C5-Branched dibasic acid metabolism" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:PWY-5087 xref: PMID:11759672 xref: PMID:9385136 is_a: UPa:UPA00351 ! L-glutamate degradation is_a: UPa:UPA00553 ! fermentation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00562 name: formaldehyde degradation namespace: pathway def: "Degradation of formaldehyde, a toxic compound for all organisms from bacteria to humans due to its reactivity with biological macromolecules (nonspecific reactivity with proteins and nucleic acids). Organisms that grow aerobically on single-carbon compounds such as methanol and methane face a special challenge in this regard because formaldehyde is a central metabolic intermediate during methylotrophic growth." [UPa:amorgat] synonym: "formaldehyde oxidation" EXACT [] synonym: "methanal oxidation" EXACT [] xref: GO:0046294 "biological_process:formaldehyde catabolic process" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:PWY-1801 xref: MetaCyc:PWY-5250 xref: PMID:11073907 xref: PMID:12123819 xref: PMID:15632161 xref: PMID:16567800 xref: PMID:9765566 is_a: UPa:UPA00445 ! one-carbon metabolism relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00563 name: L-fucose degradation namespace: pathway def: "Degradation of the methylpentose L-fucose (6-deoxygalactose)." [UPa:amorgat] synonym: "6-deoxygalactose degradation" EXACT [] xref: GO:0019317 "biological_process:fucose catabolic process" xref: KEGG:map00051 "Fructose and mannose metabolism" xref: MetaCyc:FUCCAT-PWY is_a: UPa:UPA00413 ! carbohydrate degradation is_a: UPa:UPA00956 ! L-fucose metabolism relationship: uniprot_super_pathway UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA00564 name: D-glucarate degradation namespace: pathway def: "Degradation of D-glucaric acid, an aldaric acid." [UPa:amorgat] synonym: "D-glucaric acid degradation" EXACT [] xref: GO:0042838 "biological_process:D-glucarate catabolic process" xref: KEGG:map00053 "Ascorbate and aldarate metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00794 ! aldaric acid degradation relationship: uniprot_super_pathway UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA00565 name: galactarate degradation namespace: pathway def: "Degradation of galactarate, an aldaric acid." [UPa:amorgat] synonym: "galactaric acid degradation" EXACT [] xref: GO:0046392 "biological_process:galactarate catabolic process" xref: KEGG:map00053 "Ascorbate and aldarate metabolism" is_a: UPa:UPA00794 ! aldaric acid degradation relationship: uniprot_super_pathway UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA00566 name: enterobacterial common antigen biosynthesis namespace: pathway def: "Biosynthesis of enterobacterial common antigen (ECA), a cell surface glycolipid that is present in all gram-negative enteric bacteria. The carbohydrate portion of the polymer contains: N-acetyl-D-glucosamine (GlcNAc), N-acetyl-D-mannosaminouronic acid (ManNAcA) and 4-acetamido-4,6-dideoxy-D-galactose (Fuc4NAc). These amino sugars are linked to form linear polysaccharide chains. In addition, the hydroxyl groups at position 6 of the GlcNAc residues are nonstochiometrically substituted with O-acetyl groups." [UPa:amorgat] synonym: "ECA biosynthesis" EXACT [] xref: GO:0009246 "biological_process:enterobacterial common antigen biosynthetic process" xref: PMID:10515954 xref: PMID:12618464 xref: PMID:16199561 xref: PMID:16936038 is_a: UPa:UPA00324 ! bacterial outer membrane biogenesis is_a: UPa:UPA00506 ! glycolipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00324 ! bacterial outer membrane biogenesis [Term] id: UPa:UPA00567 name: bioluminescence namespace: pathway def: "Bioluminescence is the production and emission of light by a living organism as the result of a chemical reaction during which chemical energy is converted to light energy." [UPa:amorgat] xref: GO:0008218 "biological_process:bioluminescence" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00568 name: bacterial bioluminescence namespace: pathway def: "Bacterial bioluminescence is a tightly regulated energy-consuming process. In Vibrio fischeri, luminescence is produced when luciferase, composed of LuxA and LuxB, converts FMNH2, O2 and an aliphatic aldehyde (RCHO) to FMN, water and an aliphatic acid. LuxC and LuxE recycle the aliphatic acid, which is also produced by LuxD, to regenerate the RCHO substrate, while LuxG and other proteins in the cell reduce FMN using NADH to supply luciferase with FMNH2 [PMID:17590235]." [UPa:amorgat] xref: PMID:17590235 is_a: UPa:UPA00567 ! bioluminescence [Term] id: UPa:UPA00569 name: fatty acid reduction for biolumincescence namespace: pathway def: "Fatty acid reduction for bacterial biolumincescence." [UPa:amorgat] is_a: UPa:UPA00199 ! fatty acid metabolism is_a: UPa:UPA00568 ! bacterial bioluminescence relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00570 name: pyrimidine metabolism namespace: pathway def: "Metabolism of pyrimidine derivative compounds (nucleotides, nucleosides, nucleobases)." [UPa:amorgat] synonym: "pyrimidine derivative metabolism" EXACT [] is_a: UPa:UPA00433 ! aromatic compound metabolism is_a: UPa:UPA00523 ! heterocycle metabolism [Term] id: UPa:UPA00571 name: pyrimidine biosynthesis namespace: pathway def: "Biosynthesis of pyrimidine derivative compounds (nucleotides, nucleosides, nucleobases). Cytosine, thymine, and uracil are the three nucleobases found in nucleic acids." [UPa:amorgat] synonym: "pyrimidine derivative biosynthesis" EXACT [] is_a: UPa:UPA00570 ! pyrimidine metabolism [Term] id: UPa:UPA00572 name: UMP biosynthesis namespace: pathway def: "Biosynthesis of UMP nucleotide (uridine monophosphate). UMP is the pivotal nucleotide from which uridine nucleotide di- and triphosphates are formed by ATP-dependent kinases." [UPa:amorgat] synonym: "uridine monophosphate biosynthesis" EXACT [] xref: GO:0006222 "biological_process:UMP biosynthetic process" is_a: UPa:UPA00571 ! pyrimidine biosynthesis [Term] id: UPa:UPA00573 name: pyrimidine salvage namespace: pathway def: "In pyrimidine salvage, nucleosides generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, enabling them to re-enter the pathways of pyrimidine biosynthesis. Pyrimidine salvage, similarly to purines, involves a single enzymatic step but, unlike purines, occurs at the nucleoside rather than the base level in humans, with salvage predominating over synthesis." [UPa:amorgat] xref: GO:0008655 "biological_process:pyrimidine-containing compound salvage" is_a: UPa:UPA00571 ! pyrimidine biosynthesis [Term] id: UPa:UPA00574 name: UMP biosynthesis via salvage pathway namespace: pathway def: "Biosynthesis of UMP via salvage of pyrimidine derivatives (cytidine, uridine, cytosine)." [UPa:amorgat] synonym: "uridine monophosphate biosynthesis via salvage pathway" EXACT [] xref: GO:0044206 "biological_process:UMP salvage" xref: KEGG:map00240 "Pyrimidine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00572 ! UMP biosynthesis is_a: UPa:UPA00573 ! pyrimidine salvage relationship: uniprot_super_pathway UPa:UPA00570 ! pyrimidine metabolism [Term] id: UPa:UPA00575 name: dTTP biosynthesis namespace: pathway def: "Biosynthesis of dTTP (deoxythymidine triphosphate)." [UPa:amorgat] xref: GO:0006235 "biological_process:dTTP biosynthetic process" xref: PMID:8631667 is_a: UPa:UPA00089 ! deoxyribonucleotide biosynthesis is_a: UPa:UPA00571 ! pyrimidine biosynthesis relationship: uniprot_super_pathway UPa:UPA00570 ! pyrimidine metabolism [Term] id: UPa:UPA00576 name: CTP biosynthesis namespace: pathway def: "Biosynthesis of CTP nucleotide (cytidine triphosphate)." [UPa:amorgat] synonym: "cytidine triphosphate biosynthesis" EXACT [] xref: GO:0006241 "biological_process:CTP biosynthetic process" is_a: UPa:UPA00571 ! pyrimidine biosynthesis [Term] id: UPa:UPA00577 name: dTMP biosynthesis namespace: pathway def: "Biosynthesis of dTMP (deoxythymidine monophosphate)." [UPa:amorgat] xref: GO:0006231 "biological_process:dTMP biosynthetic process" is_a: UPa:UPA00089 ! deoxyribonucleotide biosynthesis is_a: UPa:UPA00571 ! pyrimidine biosynthesis [Term] id: UPa:UPA00578 name: dTMP biosynthesis via salvage pathway namespace: pathway def: "Biosynthesis of dTMP via pyrimidine salvage pathway." [UPa:amorgat] synonym: "deoxythymidine monophosphate biosynthesis via salvage pathway" EXACT [] xref: KEGG:map00240 "Pyrimidine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00573 ! pyrimidine salvage is_a: UPa:UPA00577 ! dTMP biosynthesis relationship: uniprot_super_pathway UPa:UPA00570 ! pyrimidine metabolism [Term] id: UPa:UPA00579 name: CTP biosynthesis via salvage pathway namespace: pathway def: "Biosynthesis of CTP starting from cytidine (salvage pathway)." [UPa:amorgat] synonym: "cytosine triphosphate biosynthesis via salvage pathway" EXACT [] xref: GO:0044211 "biological_process:CTP salvage" xref: KEGG:map00240 "Pyrimidine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00576 ! CTP biosynthesis relationship: uniprot_super_pathway UPa:UPA00570 ! pyrimidine metabolism [Term] id: UPa:UPA00580 name: pyrimidine degradation namespace: pathway def: "Degradation of pyrimidine derivative compounds (nucleotides, nucleosides, nucleobases)." [UPa:amorgat] synonym: "pyrimidine derivative degradation" EXACT [] is_a: UPa:UPA00570 ! pyrimidine metabolism [Term] id: UPa:UPA00581 name: uracil degradation namespace: pathway def: "Degradation of uracil nucleobase." [UPa:amorgat] xref: GO:0006212 "biological_process:uracil catabolic process" is_a: UPa:UPA00580 ! pyrimidine degradation [Term] id: UPa:UPA00582 name: uracil degradation via oxidative pathway namespace: pathway def: "Oxidative degradation of uracil nucleobase." [UPa:amorgat] xref: KEGG:map00240 "Pyrimidine metabolism" is_a: UPa:UPA00581 ! uracil degradation relationship: uniprot_super_pathway UPa:UPA00570 ! pyrimidine metabolism [Term] id: UPa:UPA00583 name: purine metabolism namespace: pathway def: "Metabolism of purine derivative compounds (nucleotides, nucleosides, nucleobases)." [UPa:amorgat] synonym: "purine derivative metabolism" EXACT [] is_a: UPa:UPA00433 ! aromatic compound metabolism is_a: UPa:UPA00523 ! heterocycle metabolism [Term] id: UPa:UPA00584 name: purine biosynthesis namespace: pathway def: "Biosynthesis of purine derivative compounds (nucleotides, nucleosides, nucleobases)." [UPa:amorgat] synonym: "purine derivative biosynthesis" EXACT [] is_a: UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00585 name: purine degradation namespace: pathway def: "Degradation of purine derivative compounds (nucleotides, nucleosides, nucleobases). Purine degradation has an essential role in nitrogen metabolism in most organism." [UPa:amorgat] synonym: "purine derivative degradation" EXACT [] is_a: UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00586 name: purine biosynthesis via salvage pathway namespace: pathway def: "In purine salvage, nucleosides generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, enabling them to re-enter the pathways of purine biosynthesis." [UPa:amorgat] is_a: UPa:UPA00584 ! purine biosynthesis [Term] id: UPa:UPA00587 name: adenine biosynthesis via salvage pathway namespace: pathway def: "Biosynthesis of adenine through purine salvage." [UPa:amorgat] is_a: UPa:UPA00586 ! purine biosynthesis via salvage pathway [Term] id: UPa:UPA00588 name: AMP biosynthesis via salvage pathway namespace: pathway def: "Biosynthesis of AMP through purine salvage." [UPa:amorgat] xref: GO:0044209 "biological_process:AMP salvage" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00586 ! purine biosynthesis via salvage pathway is_a: UPa:UPA00592 ! AMP biosynthesis relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00589 name: inosine biosynthesis via salvage pathway namespace: pathway def: "Biosynthesis of inosine through purine salvage." [UPa:amorgat] synonym: "inosine salvage" EXACT [] xref: GO:0006190 "biological_process:inosine salvage" is_a: UPa:UPA00586 ! purine biosynthesis via salvage pathway is_a: UPa:UPA00594 ! inosine biosynthesis [Term] id: UPa:UPA00590 name: hypoxanthine biosynthesis via salvage pathway namespace: pathway def: "Biosynthesis of hypoxanthine through purine salvage." [UPa:amorgat] synonym: "hypoxanthine salvage" EXACT [] xref: GO:0043103 "biological_process:hypoxanthine salvage" is_a: UPa:UPA00586 ! purine biosynthesis via salvage pathway [Term] id: UPa:UPA00591 name: IMP biosynthesis via salvage pathway namespace: pathway def: "Biosynthesis of inosine 5'-phosphate (IMP) through purine salvage." [UPa:amorgat] synonym: "IMP salvage" EXACT [] synonym: "inosine 5'-phosphate biosynthesis via salvage pathway" EXACT [] synonym: "inosine monophosphate biosynthesis via salvage pathway" EXACT [] xref: GO:0032264 "biological_process:IMP salvage" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00586 ! purine biosynthesis via salvage pathway is_a: UPa:UPA00648 ! IMP biosynthesis relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00592 name: AMP biosynthesis namespace: pathway def: "Biosynthesis of adenosine 5'-phosphate, a purine nucleotide." [UPa:amorgat] synonym: "adenosine 5'-phosphate biosynthesis" EXACT [] synonym: "adenosine monophosphate biosynthesis" EXACT [] xref: GO:0006167 "biological_process:AMP biosynthetic process" is_a: UPa:UPA00488 ! purine nucleotide biosynthesis [Term] id: UPa:UPA00593 name: purine biosynthesis via de novo pathway namespace: pathway def: "Biosynthesis of purine derivative via de novo pathway." [UPa:amorgat] is_a: UPa:UPA00584 ! purine biosynthesis [Term] id: UPa:UPA00594 name: inosine biosynthesis namespace: pathway def: "Biosynthesis of inosine purine nucleobase." [UPa:amorgat] xref: GO:0046103 "biological_process:inosine biosynthetic process" is_a: UPa:UPA00524 ! purine base biosynthesis [Term] id: UPa:UPA00595 name: purine base degradation namespace: pathway def: "Degradation of purine base compounds." [UPa:amorgat] xref: GO:0006145 "biological_process:purine nucleobase catabolic process" is_a: UPa:UPA00400 ! purine base metabolism is_a: UPa:UPA00585 ! purine degradation [Term] id: UPa:UPA00596 name: second messenger metabolism namespace: pathway def: "Metabolism of second messengers, molecular signals (ions or small molecules) released into the cytosol, thereby helping relay the signal within the cell." [UPa:amorgat] is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00597 name: second messenger biosynthesis namespace: pathway def: "Biosynthesis of second messengers, molecular signals (ions or small molecules) released into the cytosol, thereby helping relay the signal within the cell." [UPa:amorgat] is_a: UPa:UPA00596 ! second messenger metabolism [Term] id: UPa:UPA00598 name: cyclic nucleotide biosynthesis namespace: pathway def: "Biosynthesis of cyclic nucleotides, any nucleotide in which the phosphate group is bonded to two of the sugar's hydroxyl groups, forming a cyclical or ring structure. Examples: cAMP, cGMP, c-di-GMP, etc." [UPa:amorgat] xref: GO:0009190 "biological_process:cyclic nucleotide biosynthetic process" is_a: UPa:UPA00424 ! nucleotide biosynthesis is_a: UPa:UPA00759 ! cyclic nucleotide metabolism [Term] id: UPa:UPA00599 name: 3',5'-cyclic di-GMP biosynthesis namespace: pathway def: "Biosynthesis of cyclic dinucleotide 3',5'-cyclic di-GMP (c-di-GMP), a purine nucleotide emerging as a novel global second messenger in bacteria. In many bacteria bis-(3',5')-cyclic dimeric guanosine monophosphate (c-di-GMP) signaling determines the timing and amplitude of complex biological processes from biofilm formation and virulence to photosynthesis." [UPa:amorgat] synonym: "bis-(3',5')-cyclic dimeric guanosine monophosphate biosynthesis" EXACT [] synonym: "c-di-GMP biosynthesis" EXACT [] synonym: "cGpGp biosynthesis" EXACT [] xref: PMID:15063857 xref: PMID:15569936 xref: PMID:16045609 is_a: UPa:UPA00488 ! purine nucleotide biosynthesis is_a: UPa:UPA00597 ! second messenger biosynthesis is_a: UPa:UPA00598 ! cyclic nucleotide biosynthesis relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00600 name: XMP biosynthesis namespace: pathway def: "Biosynthesis of xanthosine 5'-phosphate (XMP purine nucleotide)." [UPa:amorgat] synonym: "xanthosine 5'-phosphate biosynthesis" EXACT [] synonym: "xanthosine monophosphate biosynthesis" EXACT [] xref: GO:0097293 {source="rdfmatch"} is_a: UPa:UPA00488 ! purine nucleotide biosynthesis [Term] id: UPa:UPA00601 name: XMP biosynthesis via de novo pathway namespace: pathway def: "Biosynthesis of xanthosine 5'-phosphate (XMP purine nucleotide) via de novo pathway." [UPa:amorgat] synonym: "xanthosine monophosphate biosynthesis via de novo pathway" EXACT [] xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00593 ! purine biosynthesis via de novo pathway is_a: UPa:UPA00600 ! XMP biosynthesis relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00602 name: XMP biosynthesis via salvage pathway namespace: pathway def: "Biosynthesis of xanthosine 5'-phosphate (XMP purine nucleotide) via salvage pathway." [UPa:amorgat] synonym: "xanthosine 5'-phosphate biosynthesis via salvage pathway" EXACT [] synonym: "xanthosine monophosphate biosynthesis via salvage pathway" EXACT [] xref: GO:0032265 "biological_process:XMP salvage" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00586 ! purine biosynthesis via salvage pathway is_a: UPa:UPA00600 ! XMP biosynthesis relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00603 name: guanine degradation namespace: pathway def: "Degradation of guanine purine nucleobase." [UPa:amorgat] xref: GO:0006147 "biological_process:guanine catabolic process" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00586 ! purine biosynthesis via salvage pathway is_a: UPa:UPA00595 ! purine base degradation relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00604 name: hypoxanthine degradation namespace: pathway def: "Degradation of hypoxanthine purine base into uric acid." [UPa:amorgat] xref: GO:0009114 "biological_process:hypoxanthine catabolic process" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00586 ! purine biosynthesis via salvage pathway is_a: UPa:UPA00595 ! purine base degradation relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00605 name: purine nucleoside metabolism namespace: pathway def: "Metabolism of purine nucleoside compounds." [UPa:amorgat] xref: GO:0042278 "biological_process:purine nucleoside metabolic process" is_a: UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00606 name: purine nucleoside salvage namespace: pathway def: "Salvage of purine nucleoside compounds." [UPa:amorgat] is_a: UPa:UPA00586 ! purine biosynthesis via salvage pathway is_a: UPa:UPA00608 ! purine nucleoside biosynthesis relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00607 name: purine nucleoside degradation namespace: pathway def: "Degradation of purine nucleoside compounds." [UPa:amorgat] xref: GO:0006152 "biological_process:purine nucleoside catabolic process" is_a: UPa:UPA00585 ! purine degradation is_a: UPa:UPA00605 ! purine nucleoside metabolism [Term] id: UPa:UPA00608 name: purine nucleoside biosynthesis namespace: pathway def: "Biosynthesis of purine nucleoside compounds." [UPa:amorgat] xref: GO:0042451 "biological_process:purine nucleoside biosynthetic process" is_a: UPa:UPA00425 ! nucleoside biosynthesis is_a: UPa:UPA00584 ! purine biosynthesis is_a: UPa:UPA00605 ! purine nucleoside metabolism [Term] id: UPa:UPA00609 name: CDP-diacylglycerol degradation namespace: pathway def: "Degradation of CDP-diacylglycerol compounds." [UPa:amorgat] xref: GO:0046342 "biological_process:CDP-diacylglycerol catabolic process" xref: KEGG:map00564 "Glycerophospholipid metabolism" is_a: UPa:UPA00752 ! phospholipid degradation relationship: uniprot_super_pathway UPa:UPA00085 ! phospholipid metabolism [Term] id: UPa:UPA00610 name: dUMP biosynthesis namespace: pathway def: "Biosynthesis of dUMP (deoxyuridine 5'-phosphate), a pyrimidine deoxyribonucleotide." [UPa:amorgat] synonym: "deoxyuridine 5'-phosphate biosynthesis" EXACT [] xref: GO:0006226 "biological_process:dUMP biosynthetic process" xref: KEGG:map00240 "Pyrimidine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00089 ! deoxyribonucleotide biosynthesis is_a: UPa:UPA00571 ! pyrimidine biosynthesis relationship: uniprot_super_pathway UPa:UPA00570 ! pyrimidine metabolism [Term] id: UPa:UPA00611 name: alcohol metabolism namespace: pathway def: "Metabolism of alcohol compounds." [UPa:amorgat] xref: GO:0006066 "biological_process:alcohol metabolic process" is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00612 name: alcohol degradation namespace: pathway def: "Degradation of alcohol compounds." [UPa:amorgat] xref: GO:0046164 "biological_process:alcohol catabolic process" is_a: UPa:UPA00611 ! alcohol metabolism [Term] id: UPa:UPA00613 name: polyol metabolism namespace: pathway def: "Metabolism of polyol compounds." [UPa:amorgat] xref: GO:0019751 "biological_process:polyol metabolic process" is_a: UPa:UPA00611 ! alcohol metabolism [Term] id: UPa:UPA00614 name: polyol degradation namespace: pathway def: "Degradation of polyol compounds." [UPa:amorgat] xref: GO:0046174 "biological_process:polyol catabolic process" is_a: UPa:UPA00612 ! alcohol degradation is_a: UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00615 name: glycerol metabolism namespace: pathway def: "Metabolism of the trihydric alcohol, glycerol." [UPa:amorgat] synonym: "1,2,3-trihydroxypropane metabolism" EXACT [] xref: GO:0006071 "biological_process:glycerol metabolic process" is_a: UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00616 name: glycerol degradation namespace: pathway def: "Degradation of glycerol, a trihydric alcohol. Two possible routes of glycerol catabolism have been proposed. In the first pathway, glycerol is phosphorylated to glycerol-3-phosphate by glycerol kinase, and then converted to dihydroxyacetone phosphate by glycerol-3-phosphate dehydrogenase. In the second pathway, glycerol is converted to dihydroxyacetone by NAD-dependent glycerol dehydrogenase, and then phosphorylated to dihydroxyacetone phosphate by dihydroxyacetone kinase." [UPa:amorgat] synonym: "1,2,3-propanetriol degradation" EXACT [] xref: GO:0019563 "biological_process:glycerol catabolic process" is_a: UPa:UPA00614 ! polyol degradation is_a: UPa:UPA00615 ! glycerol metabolism relationship: uniprot_super_pathway UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00617 name: glycerol fermentation namespace: pathway def: "In the absence of an external oxidant, glycerol is consumed by a dismutation process involving two sub-pathways. Through one sub-pathway (oxidative route), glycerol is dehydrogenated by an NAD+-linked glycerol dehydrogenase (DhaD) to dihydroxyacetone. This product is then phosphorylated by dihydroxyacetone kinase (DhaK) and funnelled to the central metabolism. Through the other sub-pathway (reductive route), glycerol is dehydrated by coenzyme B12-dependent glycerol dehydratase (DhaB, DhaC, DhaE) to form 3-hydroxypropionaldehyde, which is reduced to the major fermentation product 1,3-propanediol by the NADH-linked 1,3-propanediol dehydrogenase (DhaT), thereby regenerating NAD+ [PMID: 9311132]." [UPa:amorgat] synonym: "anaerobic glycerol degradation" EXACT [] xref: GO:0019588 "biological_process:anaerobic glycerol catabolic process" xref: KEGG:map00561 "Glycerolipid metabolism" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:GLYCEROLMETAB-PWY xref: MetaCyc:GOLPDLCAT-PWY xref: PMID:7721705 xref: PMID:9311132 is_a: UPa:UPA00553 ! fermentation is_a: UPa:UPA00616 ! glycerol degradation relationship: uniprot_super_pathway UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00618 name: glycerol degradation via glycerol kinase pathway namespace: pathway def: "In bacteria, glycerol uptake is mediated by the glycerol diffusion facilitator, an integral membrane protein catalyzing the rapid equilibration of concentration gradients of glycerol across the cytoplasmic membrane. Intracellular glycerol is converted to glycerol-3-phosphate that is further metabolized to dihydroxyacetone phosphate (DHAP) by either of two membrane-bound enzymes, depending on the growth conditions." [UPa:amorgat] xref: GO:0019563 "biological_process:glycerol catabolic process" xref: KEGG:map00561 "Glycerolipid metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:PWY-4261 xref: MetaCyc:PWY0-381 is_a: UPa:UPA00616 ! glycerol degradation relationship: uniprot_super_pathway UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00619 name: methylglyoxal degradation namespace: pathway def: "Methylglyoxal (MG) is a cytotoxic compound formed primarily as a by-product of carbohydrate and lipid metabolism. It is catabolised by glyoxalases I and II, the zinc-binding enzymes of the glyoxalase pathway. Glyoxalase system is present in the cytosol of cells and cellular organelles, particularly mitochondria." [UPa:amorgat] synonym: "glyoxal pathway" EXACT [] synonym: "glyoxalase pathway" EXACT [] synonym: "glyoxalase system" EXACT [] xref: KEGG:map00620 "Pyruvate metabolism" xref: PMID:2198020 is_a: UPa:UPA00465 ! secondary metabolite metabolism relationship: uniprot_super_pathway UPa:UPA00465 ! secondary metabolite metabolism [Term] id: UPa:UPA00620 name: propanediol metabolism namespace: pathway def: "Metabolism of diol alcohol propanediol compounds." [UPa:amorgat] xref: GO:0019563 "biological_process:glycerol catabolic process" is_a: UPa:UPA00615 ! glycerol metabolism [Term] id: UPa:UPA00621 name: 1,2-propanediol degradation namespace: pathway def: "Degradation of the diol alcohol, 1,2-propanediol (propane-1,2-diol)." [UPa:amorgat] synonym: "1,2 propylene glycol degradation" EXACT [] synonym: "1,2-dihydroxypropane degradation" EXACT [] synonym: "propane-1,2-diol degradation" EXACT [] xref: GO:0051144 "biological_process:propanediol catabolic process" is_a: UPa:UPA00614 ! polyol degradation is_a: UPa:UPA00620 ! propanediol metabolism relationship: uniprot_super_pathway UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00622 name: alcohol biosynthesis namespace: pathway def: "Biosynthesis of alcohol compounds." [UPa:amorgat] xref: GO:0046165 "biological_process:alcohol biosynthetic process" is_a: UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00623 name: polyol biosynthesis namespace: pathway def: "Biosynthesis of polyol compounds." [UPa:amorgat] xref: GO:0046173 "biological_process:polyol biosynthetic process" is_a: UPa:UPA00622 ! alcohol biosynthesis [Term] id: UPa:UPA00624 name: glycerol biosynthesis namespace: pathway def: "Biosynthesis of the trihydric alcohol, glycerol (1,2,3-propanetriol)." [UPa:amorgat] synonym: "1,2,3-propanetriol biosynthesis" EXACT [] xref: GO:0006114 "biological_process:glycerol biosynthetic process" is_a: UPa:UPA00615 ! glycerol metabolism is_a: UPa:UPA00623 ! polyol biosynthesis relationship: uniprot_super_pathway UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00625 name: (R,R)-butane-2,3-diol metabolism namespace: pathway def: "Metabolism of 2,3-butanediol. 2,3-butanediol (2,3-BDL), which is very important for a variety of chemical feedstocks and liquid fuels, can be derived from the bioconversion of natural resources. The metabolic function of 2,3-butanediol is not yet known, although it may play a role in preventing intracellular acidification by changing the metabolism from acid production to the formation of a neutral compound." [UPa:amorgat] xref: PMID:6298028 is_a: UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00626 name: (R,R)-butane-2,3-diol biosynthesis namespace: pathway def: "In some bacteria, pyruvate can be channeled via alpha-acetolactate into neutral compound 2,3-butanediol. The production of (R,R)-2,3-butanediol is enhanced when oxygen is limited and the pH is lowered." [UPa:amorgat] synonym: "2,3-butanediol biosynthesis" EXACT [] synonym: "2,3-butanediol pathway" EXACT [] xref: KEGG:map00650 "Butanoate metabolism" xref: KEGG:map00660 "C5-Branched dibasic acid metabolism" xref: MetaCyc:P125-PWY xref: PMID:11234948 xref: PMID:8444801 is_a: UPa:UPA00623 ! polyol biosynthesis is_a: UPa:UPA00625 ! (R,R)-butane-2,3-diol metabolism relationship: uniprot_super_pathway UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00627 name: amino-sugar degradation namespace: pathway def: "Degradation of amino-sugar compounds." [UPa:amorgat] synonym: "amino sugar degradation" EXACT [] synonym: "aminosugar degradation" EXACT [] xref: GO:0046348 "biological_process:amino sugar catabolic process" is_a: UPa:UPA00216 ! amino-sugar metabolism is_a: UPa:UPA00413 ! carbohydrate degradation is_a: UPa:UPA00456 ! amine and polyamine degradation [Term] id: UPa:UPA00628 name: N-acetylneuraminate metabolism namespace: pathway def: "Metabolism of N-acetylneuramate, an amino sugar component of the cell surface structures." [UPa:amorgat] synonym: "sialic acid metabolism" EXACT [] xref: GO:0006054 "biological_process:N-acetylneuraminate metabolic process" xref: MetaCyc:GLCMANNANAUT-PWY is_a: UPa:UPA00216 ! amino-sugar metabolism relationship: uniprot_super_pathway UPa:UPA00216 ! amino-sugar metabolism [Term] id: UPa:UPA00629 name: N-acetylneuraminate degradation namespace: pathway def: "Degradation of N-acetylneuraminate, an amino sugar component of the cell surface structures. N-acetylneuraminate is possibly used as carbon and nitrogen sources." [UPa:amorgat] synonym: "sialic acid degradation" EXACT [] xref: GO:0019262 "biological_process:N-acetylneuraminate catabolic process" xref: KEGG:map00520 "Amino sugar and nucleotide sugar metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:GLCMANNANAUT-PWY xref: PMID:11234948 xref: PMID:9864311 is_a: UPa:UPA00627 ! amino-sugar degradation is_a: UPa:UPA00628 ! N-acetylneuraminate metabolism relationship: uniprot_super_pathway UPa:UPA00216 ! amino-sugar metabolism [Term] id: UPa:UPA00630 name: N-acetylneuraminate biosynthesis namespace: pathway def: "Biosynthesis of N-acetylneuraminic acid (Neu5Ac), the precursor of sialic acids, a group of important molecules in biological recognition systems." [UPa:amorgat] synonym: "N-acetylneuraminic acid biosynthesis" EXACT [] synonym: "Neu5Ac biosynthesis" EXACT [] synonym: "sialic acid biosynthesis" EXACT [] xref: GO:0006045 "biological_process:N-acetylglucosamine biosynthetic process" xref: PMID:10334995 xref: PMID:9305888 is_a: UPa:UPA00628 ! N-acetylneuraminate metabolism is_a: UPa:UPA00649 ! amino-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00216 ! amino-sugar metabolism [Term] id: UPa:UPA00631 name: exopolysaccharide biosynthesis namespace: pathway def: "Biosynthesis of exopolysaccharide compounds. Pseudomonas solanacearum." [UPa:amorgat] synonym: "EPS biosynthesis" EXACT [] xref: PMID:7476194 xref: PMID:8626297 is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00632 name: teichoic acid biosynthesis namespace: pathway def: "Biosynthesis of teichoic acids (TAs), a group of phosphate-rich anionic extracellular polysaccharides found covalently bound to peptidoglycan in gram-positive bacteria TAs are polymers of glycerol or ribitol linked via phosphodiester bonds. These acids can be found in the cell wall of gram-positive bacteria, such as Staphylococci, Streptococci, Bacillus, Clostridium, Corynebacterium and Listeria, and appear to extend to the surface of the peptidoglycan layer. Teichoic acids are not found in the gram-negative bacteria. Teichoic acids are negatively charged and therefore contribute to the negative charge of the gram-positive cell wall. They may also provide structural support for the cell wall and act as antigen." [UPa:amorgat] synonym: "TA biosynthesis" EXACT [] xref: GO:0019350 "biological_process:teichoic acid biosynthetic process" xref: PMID:15547257 xref: PMID:16952950 xref: PMID:17660278 xref: PMID:17981078 is_a: UPa:UPA00320 ! biopolymer biosynthesis is_a: UPa:UPA00547 ! cell wall biogenesis is_a: UPa:UPA00613 ! polyol metabolism is_a: UPa:UPA00700 ! organic acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00547 ! cell wall biogenesis [Term] id: UPa:UPA00633 name: L-glutamate biosynthesis namespace: pathway def: "Biosynthesis of L-glutamate amino-acid." [UPa:amorgat] xref: GO:0006537 "biological_process:glutamate biosynthetic process" is_a: UPa:UPA00201 ! L-glutamate metabolism is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis is_a: UPa:UPA00700 ! organic acid biosynthesis [Term] id: UPa:UPA00634 name: L-glutamate biosynthesis via GLT pathway namespace: pathway def: "Biosynthesis of L-glutamate amino-acid via glutamate synthase (GLT)." [UPa:amorgat] xref: GO:0097054 "biological_process:L-glutamate biosynthetic process" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:GLUGLNSYN-PWY xref: MetaCyc:GLUTSYN-PWY xref: MetaCyc:PWY-4341 is_a: UPa:UPA00633 ! L-glutamate biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00635 name: L-glutamate biosynthesis via GDH pathway namespace: pathway def: "Biosynthesis of L-glutamate amino-acid via glutamate dehydrogenase (GDH)." [UPa:amorgat] is_a: UPa:UPA00633 ! L-glutamate biosynthesis [Term] id: UPa:UPA00636 name: beta-glucan biosynthesis namespace: pathway def: "Biosynthesis of beta-glucans." [UPa:amorgat] xref: GO:0051274 "biological_process:beta-glucan biosynthetic process" is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00637 name: osmoregulated periplasmic glucan (OPG) biosynthesis namespace: pathway def: "Biosynthesis of osmoregulated periplasmic glucans (OPGs). OPGs occur in a wide variety of Gram-negative bacterial species. The only sugars found in the backbone of OPGs are glucosyl residues, which are bound with beta-glucosidic linkages. Generally, OPG synthesis is activated by conditions of low osmolarity. OPGs vary from 5 to 25 glucosyl residues per molecule and the glucose backbones show structural diversity among different species. [PMID:17906125]." [UPa:amorgat] synonym: "OPG biosynthesis" EXACT [] xref: PMID:17906125 is_a: UPa:UPA00636 ! beta-glucan biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00638 name: nitric oxide reduction namespace: pathway def: "Reduction of nitric oxide (NO), a compound present throughout the biosphere. In humans, tightly regulated NO synthases produce sufficient NO to poison pathogens, opportunistic organisms, and neoplastic tissue. Nitric-oxide reductases metabolize NO to N2O in anaerobic denitrifying bacteria and fungi and likely serve an additional role in minimizing NO toxicity." [UPa:amorgat] synonym: "nitric-oxid reduction" EXACT [] synonym: "NO detoxification" EXACT [] synonym: "NO reduction" EXACT [] xref: PMID:11751865 xref: PMID:15546870 is_a: UPa:UPA00652 ! nitrate reduction (denitrification) relationship: uniprot_super_pathway UPa:UPA00045 ! nitrogen metabolism [Term] id: UPa:UPA00639 name: methanogenesis namespace: pathway def: "Biosynthesis of methane, the simplest alkane." [UPa:amorgat] synonym: "methane biosynthesis" EXACT [] xref: GO:0015948 "biological_process:methanogenesis" is_a: UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00640 name: methanogenesis from CO(2) namespace: pathway def: "Biosynthesis of methane from CO(2) (carbon dioxide)." [UPa:amorgat] synonym: "methane biosynthesis from carbon dioxide" EXACT [] synonym: "methanogenesis from carbon dioxide" EXACT [] xref: GO:0019386 "biological_process:methanogenesis, from carbon dioxide" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:METHANOGENESIS-PWY is_a: UPa:UPA00639 ! methanogenesis relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00641 name: methanogenesis from methanol namespace: pathway def: "Biosynthesis of methane from methanol." [UPa:amorgat] synonym: "methane biosynthesis from methanol" EXACT [] xref: GO:0019387 "biological_process:methanogenesis, from methanol" xref: MetaCyc:CO2FORM-PWY xref: PMID:17142327 is_a: UPa:UPA00639 ! methanogenesis relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00642 name: methanogenesis from acetate namespace: pathway def: "Biosynthesis of methane from acetate. Acetate serves as a growth substrate for acetotrophic methanogens including the anaerobic archaeon Methanosarcina thermophila. Activation of acetate into acetyl-CoA is described in 'Acetyl-CoA biosynthesis' pathway." [UPa:amorgat] synonym: "methane biosynthesis from acetate" EXACT [] xref: GO:0019385 "biological_process:methanogenesis, from acetate" xref: MetaCyc:METH-ACETATE-PWY xref: PMID:15062079 is_a: UPa:UPA00639 ! methanogenesis relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00643 name: methanogenesis from methylamine namespace: pathway def: "Biosynthesis of methane from monomethylamine." [UPa:amorgat] synonym: "methane biosynthesis from monomethylamine" EXACT [] xref: MetaCyc:PWY-5247 is_a: UPa:UPA00650 ! methanogenesis from methylated amine relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00644 name: methanogenesis from dimethylamine namespace: pathway def: "Biosynthesis of methane from dimethylamine." [UPa:amorgat] synonym: "methane biosynthesis from dimethylamine" EXACT [] xref: MetaCyc:PWY-5248 is_a: UPa:UPA00650 ! methanogenesis from methylated amine relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00645 name: methanogenesis from trimethylamine namespace: pathway def: "Biosynthesis of methane from trimethylamine." [UPa:amorgat] synonym: "methane biosynthesis from trimethylamine" EXACT [] xref: MetaCyc:PWY-5250 is_a: UPa:UPA00650 ! methanogenesis from methylated amine relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00646 name: methyl-coenzyme M reduction namespace: pathway def: "The conversion of methyl-CoM to methane is the final step in the methanogenesis process. This process involves the reduction of the coenzyme M-bound methyl group to methane. This step is catalyzed by methyl-coenzyme M reductase (MCR), a key enzyme that is found in all methanogens." [UPa:amorgat] xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:METHFORM-PWY is_a: UPa:UPA00639 ! methanogenesis relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00647 name: coenzyme M-coenzyme B heterodisulfide reduction namespace: pathway def: "All processes in methanogenesis lead to the formation of a mixed disulfide bond between coenzyme M and coenzyme B, by a reaction in which coenzyme B reduces methyl-coenzyme M , leading to formation of methane and a coenzyme M-coenzyme B heterodisulfide [PMID:12102556] . There are two different systems that are capable of reducing the coenzyme M-coenzyme B heterodisulfide, using either H2 or a reduced coenzyme F420 as electron donors [PMID:15168610]." [UPa:amorgat] synonym: "coenzyme B/coenzyme M regeneration" EXACT [] xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:PWY-5207 xref: PMID:12102556 xref: PMID:15168610 is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00639 ! methanogenesis relationship: uniprot_super_pathway UPa:UPA00398 ! cofactor metabolism [Term] id: UPa:UPA00648 name: IMP biosynthesis namespace: pathway def: "Biosynthesis of inosine 5'-phosphate, a purine nucleotide." [UPa:amorgat] synonym: "inosine 5'-phosphate biosynthesis" EXACT [] synonym: "inosine monophosphate biosynthesis" EXACT [] xref: GO:0006188 "biological_process:IMP biosynthetic process" is_a: UPa:UPA00488 ! purine nucleotide biosynthesis [Term] id: UPa:UPA00649 name: amino-sugar biosynthesis namespace: pathway def: "Biosynthesis of amino-sugar compounds." [UPa:amorgat] synonym: "amino sugar biosynthesis" EXACT [] synonym: "aminosugar biosynthesis" EXACT [] xref: GO:0046349 "biological_process:amino sugar biosynthetic process" is_a: UPa:UPA00216 ! amino-sugar metabolism is_a: UPa:UPA00289 ! amine and polyamine biosynthesis is_a: UPa:UPA00412 ! carbohydrate biosynthesis [Term] id: UPa:UPA00650 name: methanogenesis from methylated amine namespace: pathway def: "Biosynthesis of methane from methylated amines (mono-, di- or trimethylamine)." [UPa:amorgat] synonym: "methane biosynthesis from monomethylamine" EXACT [] is_a: UPa:UPA00639 ! methanogenesis relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00651 name: 3-deoxy-D-manno-octulosonate 4-phosphate biosynthesis namespace: pathway def: "Biosynthesis of 3-deoxy-D-manno-octulosonate 4-phosphate (KDO 4-phosphate)." [UPa:amorgat] synonym: "KDO 4-phosphate biosynthesis" EXACT [] xref: PMID:10531340 xref: PMID:10952982 is_a: UPa:UPA00301 ! LPS oligosaccharide biosynthesis is_a: UPa:UPA00412 ! carbohydrate biosynthesis relationship: uniprot_super_pathway UPa:UPA00412 ! carbohydrate biosynthesis [Term] id: UPa:UPA00652 name: nitrate reduction (denitrification) namespace: pathway def: "Denitrification is the process of reducing nitrate and nitrite, highly oxidised forms of nitrogen available for consumption by many groups of organisms, into gaseous nitrogen, which is far less accessible to life forms but makes up the bulk of atmosphere. Denitrification can be thought of as the opposite of nitrogen fixation. In general, denitrification occurs when oxygen is depleted, and bacteria turn to nitrate in order to respire organic matter. Denitrification proceeds through some combination of the following steps: nitrate -> nitrite -> nitric oxide -> nitrous oxide -> dinitrogen gas." [UPa:amorgat] synonym: "nitrate respiration" EXACT [] xref: GO:0019333 "biological_process:denitrification pathway" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:DENITRIFICATION-PWY xref: PMID:7508388 is_a: UPa:UPA00426 ! energy metabolism is_a: UPa:UPA00654 ! nitrate reduction relationship: uniprot_super_pathway UPa:UPA00045 ! nitrogen metabolism [Term] id: UPa:UPA00653 name: nitrate reduction (assimilation) namespace: pathway def: "Reduction of nitrate into to nitrite via assimilation pathway." [UPa:amorgat] synonym: "assimilatory nitrate reduction" EXACT [] synonym: "nitrate assimilation" EXACT [] xref: GO:0042128 "biological_process:nitrate assimilation" xref: MetaCyc:PWY-381 xref: PMID:8169203 xref: PMID:8468296 is_a: UPa:UPA00654 ! nitrate reduction relationship: uniprot_super_pathway UPa:UPA00045 ! nitrogen metabolism [Term] id: UPa:UPA00654 name: nitrate reduction namespace: pathway def: "The uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances. [GO:0042128]." [UPa:amorgat] xref: GO:0042128 "biological_process:nitrate assimilation" is_a: UPa:UPA00045 ! nitrogen metabolism [Term] id: UPa:UPA00655 name: malonyl-CoA biosynthesis namespace: pathway def: "Biosynthesis of malonyl-CoA." [UPa:amorgat] xref: GO:2001295 "biological_process:malonyl-CoA biosynthetic process" xref: KEGG:map00253 "Tetracycline biosynthesis" xref: KEGG:map00620 "Pyruvate metabolism" xref: KEGG:map00640 "Propanoate metabolism" xref: KEGG:map00720 "Carbon fixation pathways in prokaryotes" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00094 ! fatty acid biosynthesis is_a: UPa:UPA00415 ! metabolic intermediate biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00656 name: short-chain fatty acid metabolism namespace: pathway def: "Metabolism of short-chain fatty acid compounds." [UPa:amorgat] xref: GO:0046459 "biological_process:short-chain fatty acid metabolic process" is_a: UPa:UPA00199 ! fatty acid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00657 name: rhamnolipid biosynthesis namespace: pathway def: "Biosynthesis of rhamnolipid compounds. Rhamnolipids are extracellular biosurfactants and virulence factors secreted by the opportunistic human pathogen Pseudomonas aeruginosa that are required for swarming motility." [UPa:amorgat] xref: PMID:16624803 xref: PMID:9721281 is_a: UPa:UPA00094 ! fatty acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00658 name: polyunsaturated fatty acid biosynthesis namespace: pathway def: "Biosynthesis of polyunsaturated fatty acid compounds." [UPa:amorgat] xref: GO:0006636 "biological_process:unsaturated fatty acid biosynthetic process" is_a: UPa:UPA00094 ! fatty acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00659 name: fatty acid beta-oxidation namespace: pathway def: "The metabolic oxidation of a long-chain fatty acid by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A [GO:0006635]." [UPa:amorgat] synonym: "beta-oxidation cycle" EXACT [] xref: GO:0006635 "biological_process:fatty acid beta-oxidation" is_a: UPa:UPA00430 ! fatty acid degradation relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00660 name: mitochondrial fatty acid beta-oxidation namespace: pathway def: "Beta-oxidation of fatty acids in mitochondrion." [UPa:amorgat] is_a: UPa:UPA00659 ! fatty acid beta-oxidation relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00661 name: peroxisomal fatty acid beta-oxidation namespace: pathway def: "Beta-oxidation of fatty acids in peroxisome." [UPa:amorgat] xref: GO:0033540 "biological_process:fatty acid beta-oxidation using acyl-CoA oxidase" is_a: UPa:UPA00199 ! fatty acid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00662 name: prostaglandin biosynthesis namespace: pathway def: "Biosynthesis of prostaglandins, a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring." [UPa:amorgat] xref: GO:0001516 "biological_process:prostaglandin biosynthetic process" is_a: UPa:UPA00094 ! fatty acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00663 name: lipoprotein biosynthesis namespace: pathway def: "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids [GO:0042158] Both gram-positive and gram-negative bacteria contain lipoproteins that are a functionally diverse group of surface proteins. The roles assigned to lipoproteins include substrate binding coupled to ABC transport systems, sensing of environmental signals, antibiotic resistance, respiration, germination, conjugation, adherence to and invasion of eukaryotic cells, control of protein secretion and folding, modulation of the immune response, and maintenance of envelope integrity. Upon processing, lipoproteins are ultimately tethered to the membrane via a lipid moiety, diacylglycerol, which is covalently bound to an N-terminal conserved cysteine residue." [UPa:amorgat] xref: GO:0042158 "biological_process:lipoprotein biosynthetic process" xref: PMID:17071755 xref: PMID:7868582 is_a: UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00664 name: lipoprotein biosynthesis (diacylglyceryl transfer) namespace: pathway def: "The first step of lipoprotein biosynthesis consist of lipidation reaction, carried out by the enzyme lipoprotein diacylglyceryl transferase (Lgt)." [UPa:amorgat] xref: GO:0097302 {source="rdfmatch"} is_a: UPa:UPA00663 ! lipoprotein biosynthesis relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00665 name: lipoprotein biosynthesis (signal peptide cleavage) namespace: pathway def: "The second step of lipoprotein biosynthesis consist of cleavage of the signal peptide. The enzyme responsible for this reaction is the lipoprotein-specific signal peptidase II (Lsp), which recognizes a genuine L(-3)-S/A(-2)-A/G(-1)-C(+1) lipobox." [UPa:amorgat] xref: PMID:17071755 is_a: UPa:UPA00663 ! lipoprotein biosynthesis relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00666 name: lipoprotein biosynthesis (N-acyl transfer) namespace: pathway def: "The first step of lipoprotein biosynthesis consist of addition of an N-acyl moiety to the amino group of the N-terminal cysteine, This reaction is carried out by the enzyme N-acyl-transferase (Lnt)." [UPa:amorgat] xref: GO:0097303 {source="rdfmatch"} is_a: UPa:UPA00663 ! lipoprotein biosynthesis relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00667 name: L-arabinan degradation namespace: pathway def: "Degradation of L-arabinan, a branched homopolymer of L-arabinose." [UPa:amorgat] xref: GO:0031222 "biological_process:arabinan catabolic process" is_a: UPa:UPA00442 ! glycan degradation relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00668 name: chlorophyll biosynthesis namespace: pathway def: "Biosynthesis of chlorophyll, a green pigment found in most plants, algae, and cyanobacteria." [UPa:amorgat] xref: GO:0015995 "biological_process:chlorophyll biosynthetic process" is_a: UPa:UPA00499 ! pigment biosynthesis is_a: UPa:UPA00675 ! heterocycle biosynthesis is_a: UPa:UPA00678 ! porphyrin-containing compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00677 ! porphyrin-containing compound metabolism [Term] id: UPa:UPA00669 name: bacteriochlorophyll biosynthesis namespace: pathway def: "Biosynthesis of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria." [UPa:amorgat] xref: GO:0030494 "biological_process:bacteriochlorophyll biosynthetic process" is_a: UPa:UPA00499 ! pigment biosynthesis is_a: UPa:UPA00675 ! heterocycle biosynthesis is_a: UPa:UPA00678 ! porphyrin-containing compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00677 ! porphyrin-containing compound metabolism [Term] id: UPa:UPA00670 name: chlorophyll biosynthesis (light-independent) namespace: pathway def: "Light-independent biosynthesis of chlorophyll." [UPa:amorgat] xref: GO:0036068 "biological_process:light-independent chlorophyll biosynthetic process" is_a: UPa:UPA00499 ! pigment biosynthesis is_a: UPa:UPA00675 ! heterocycle biosynthesis is_a: UPa:UPA00678 ! porphyrin-containing compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00677 ! porphyrin-containing compound metabolism [Term] id: UPa:UPA00671 name: bacteriochlorophyll biosynthesis (light-independent) namespace: pathway def: "Light-independent biosynthesis of bacteriochlorophyll." [UPa:amorgat] xref: GO:0036070 "biological_process:light-independent bacteriochlorophyll biosynthetic process" is_a: UPa:UPA00499 ! pigment biosynthesis is_a: UPa:UPA00675 ! heterocycle biosynthesis is_a: UPa:UPA00678 ! porphyrin-containing compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00677 ! porphyrin-containing compound metabolism [Term] id: UPa:UPA00672 name: pigment metabolism namespace: pathway def: "Metabolism of pigment or biochrome, any material resulting in color of plant or animal cells, which is the result of selective color absorption." [UPa:amorgat] synonym: "biochrome metabolism" EXACT [] xref: GO:0042440 "biological_process:pigment metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00673 name: pigment degradation namespace: pathway def: "Degradation of pigment or biochrome." [UPa:amorgat] synonym: "biochrome degradation" EXACT [] xref: GO:0046149 "biological_process:pigment catabolic process" is_a: UPa:UPA00672 ! pigment metabolism [Term] id: UPa:UPA00674 name: chlorophyll degradation namespace: pathway def: "Degradation of chlorophyll, the green pigment found in photosynthetic organisms." [UPa:amorgat] xref: GO:0015996 "biological_process:chlorophyll catabolic process" is_a: UPa:UPA00673 ! pigment degradation is_a: UPa:UPA00676 ! heterocycle degradation is_a: UPa:UPA00679 ! porphyrin-containing compound degradation relationship: uniprot_super_pathway UPa:UPA00677 ! porphyrin-containing compound metabolism [Term] id: UPa:UPA00675 name: heterocycle biosynthesis namespace: pathway def: "Biosynthesis of heterocyclic compounds." [UPa:amorgat] xref: GO:0018130 "biological_process:heterocycle biosynthetic process" is_a: UPa:UPA00523 ! heterocycle metabolism [Term] id: UPa:UPA00676 name: heterocycle degradation namespace: pathway def: "Degradation of heterocyclic compounds." [UPa:amorgat] xref: GO:0046700 "biological_process:heterocycle catabolic process" is_a: UPa:UPA00523 ! heterocycle metabolism [Term] id: UPa:UPA00677 name: porphyrin-containing compound metabolism namespace: pathway def: "Metabolism of porphyrin-containing compounds. A porphyrin is a heterocyclic macrocycle made from 4 pyrrole subunits linked on opposite sides (alpha position) through 4 methine bridges (=CH-). Porphyrins combine readily with metals, coordinating with them in the central cavity. Iron- (heme), magnesium- (chlorophyll), zinc-, copper-, nickel-, and cobalt- containing porphyrins are known, and many other metals can be inserted." [UPa:amorgat] xref: GO:0006778 "biological_process:porphyrin-containing compound metabolic process" is_a: UPa:UPA00523 ! heterocycle metabolism [Term] id: UPa:UPA00678 name: porphyrin-containing compound biosynthesis namespace: pathway def: "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. A porphyrin is a heterocyclic macrocycle made from 4 pyrrole subunits linked on opposite sides (alpha position) through 4 methine bridges (=CH-). Porphyrins combine readily with metals, coordinating with them in the central cavity. Iron- (heme), magnesium- (chlorophyll), zinc-, copper-, nickel-, and cobalt- containing porphyrins are known, and many other metals can be inserted." [UPa:amorgat] xref: GO:0006779 "biological_process:porphyrin-containing compound biosynthetic process" is_a: UPa:UPA00677 ! porphyrin-containing compound metabolism is_a: UPa:UPA00682 ! macrocycle biosynthesis [Term] id: UPa:UPA00679 name: porphyrin-containing compound degradation namespace: pathway def: "Degradation of any member of a large group of derivatives or analogs of porphyrin. A porphyrin is a heterocyclic macrocycle made from 4 pyrrole subunits linked on opposite sides (alpha position) through 4 methine bridges (=CH-). Porphyrins combine readily with metals, coordinating with them in the central cavity. Iron- (heme), magnesium- (chlorophyll), zinc-, copper-, nickel-, and cobalt- containing porphyrins are known, and many other metals can be inserted." [UPa:amorgat] xref: GO:0006787 "biological_process:porphyrin-containing compound catabolic process" is_a: UPa:UPA00677 ! porphyrin-containing compound metabolism is_a: UPa:UPA00681 ! macrocycle degradation [Term] id: UPa:UPA00680 name: macrocycle metabolism namespace: pathway def: "Metabolism of macrocycle. A macrocycle is, as defined by IUPAC, 'a cyclic macromolecule or a macromolecular cyclic portion of a molecule'." [UPa:amorgat] is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00681 name: macrocycle degradation namespace: pathway def: "Degradation of macrocycle, like heme, chlorophyll, vitamin B12, etc." [UPa:amorgat] is_a: UPa:UPA00680 ! macrocycle metabolism [Term] id: UPa:UPA00682 name: macrocycle biosynthesis namespace: pathway def: "Biosynthesis of macrocycle, like heme, chlorophyll, vitamin B12, etc." [UPa:amorgat] is_a: UPa:UPA00680 ! macrocycle metabolism [Term] id: UPa:UPA00683 name: spheroidene biosynthesis namespace: pathway def: "Biosynthesis of spheroidene carotenoids from neurosporene." [UPa:amorgat] xref: GO:1901180 {source="rdfmatch"} xref: PMID:2747617 is_a: UPa:UPA00386 ! carotenoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00684 name: protoheme degradation namespace: pathway def: "Degradation of heme. Bilirubin is a yellow breakdown product of normal heme catabolism." [UPa:amorgat] xref: GO:1900548 {source="rdfmatch"} is_a: UPa:UPA00679 ! porphyrin-containing compound degradation relationship: uniprot_super_pathway UPa:UPA00677 ! porphyrin-containing compound metabolism [Term] id: UPa:UPA00685 name: (2,4-dichlorophenoxy)acetate degradation namespace: pathway def: "Degradation of (2,4-dichlorophenoxy)acetate, a chlorinated phenoxy compound. (2,4-dichlorophenoxy)acetate functions as a systemic herbicide and is used to control many types of broadleaf weeds." [UPa:amorgat] xref: GO:0046300 "biological_process:2,4-dichlorophenoxyacetic acid catabolic process" is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00686 name: (2,4,5-trichlorophenoxy)acetate degradation namespace: pathway def: "Degradation of (2,4,5-trichlorophenoxy)acetate, a chlorinated phenoxy compound." [UPa:amorgat] xref: GO:0046228 "biological_process:2,4,5-trichlorophenoxyacetic acid catabolic process" is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00688 name: dichloromethane degradation namespace: pathway def: "Degradation of dichloromethane, a highly volatile solvent which finds application in a wide variety of industrial and commercial processes. Dibromomethane has been observed to occur naturally [PMID:7272274]." [UPa:amorgat] synonym: "DCM degradation" EXACT [] xref: PMID:7272274 is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00689 name: gamma-hexachlorocyclohexane degradation namespace: pathway def: "Degradation of gamma-hexachlorocyclohexane (g-HCH, BHC, lindane), a halogenated organic insecticide that has been used worldwide for agriculture and public health. It is degraded rapidly under anaerobic conditions, but is considered extremely persistent in upland soil." [UPa:amorgat] synonym: "BHC degradation" EXACT [] synonym: "g-HCH degradation" EXACT [] synonym: "g-hexachlorocyclohexane degradation" EXACT [] synonym: "lindane degradation" EXACT [] xref: MetaCyc:GAMMAHEXCHLORDEG-PWY is_a: UPa:UPA00690 ! hexachlorocyclohexane degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00690 name: hexachlorocyclohexane degradation namespace: pathway def: "Degradation of hexachlorocyclohexane (HCH), a xenobiotic compound used extensively against agricultural pests and in public health programs for the control of mosquitoes. Commercial formulations of HCH consist of a mixture of four isomers, alpha, beta, gamma, and delta. While all these isomers pose serious environmental problems, beta-HCH is more problematic due to its longer persistence in the environment." [UPa:amorgat] synonym: "HCH degradation" EXACT [] is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00691 name: pentachlorophenol degradation namespace: pathway def: "Degradation of pentachlorophenol (PCP), a chlorinated insecticide and fungicide. It is used primarily to protect timber from fungal rot and wood boring insects. PCP is significantly toxic to mammals, plants, and many microorganisms. Despite this, bacteria have been identified that are resistant to relatively high PCP concentrations and can metabolize it to carbon dioxide and chloride. Bacteria have been used successfully in PCP bioremediation." [UPa:amorgat] synonym: "PCP degradation" EXACT [] xref: GO:0019338 "biological_process:pentachlorophenol catabolic process" xref: MetaCyc:PCPDEG-PWY is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00692 name: cellulose metabolism namespace: pathway def: "Metabolism of cellulose, the most abundant biopolymer on earth, recognized as the major component of plant biomass but also representative of microbial extracellular polymers. Bacterial cellulose (BC) belongs to specific product of primary metabolism and is mainly a protective coating, whereas plant cellulose (PC) plays a structural role. Cellulose is an unbranched polymer of beta-1-4 linked glucopyranose residues Plant cellulose and bacterial cellulose have the same chemical structure, but different physical and chemical properties." [UPa:amorgat] xref: GO:0030243 "biological_process:cellulose metabolic process" is_a: UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00693 name: cellulose biosynthesis namespace: pathway def: "Biosynthesis of cellulose." [UPa:amorgat] xref: GO:0030244 "biological_process:cellulose biosynthetic process" is_a: UPa:UPA00484 ! glycan biosynthesis is_a: UPa:UPA00692 ! cellulose metabolism [Term] id: UPa:UPA00694 name: bacterial cellulose biosynthesis namespace: pathway def: "Biosynthesis of bacterial cellulose." [UPa:amorgat] xref: GO:0090540 {source="rdfmatch"} is_a: UPa:UPA00693 ! cellulose biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00695 name: plant cellulose biosynthesis namespace: pathway def: "Biosynthesis of plant cellulose." [UPa:amorgat] is_a: UPa:UPA00693 ! cellulose biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00696 name: cellulose degradation namespace: pathway def: "Degradation of cellulose." [UPa:amorgat] xref: GO:0030245 "biological_process:cellulose catabolic process" is_a: UPa:UPA00442 ! glycan degradation is_a: UPa:UPA00692 ! cellulose metabolism relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00697 name: hemicellulose degradation namespace: pathway def: "Degradation of hemicellulose, a branched polymer of sugar monomers. For instance, besides glucose, sugar monomers in hemicellulose can include xylose, mannose, galactose, rhamnose, and arabinose. Hemicelluloses contain most of the D-pentose sugars, and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present." [UPa:amorgat] is_a: UPa:UPA00442 ! glycan degradation relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00698 name: organic acid metabolism namespace: pathway def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. [GO:0006082]." [UPa:amorgat] xref: GO:0006082 "biological_process:organic acid metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00699 name: organic acid degradation namespace: pathway def: "Degradation of organic acids." [UPa:amorgat] xref: GO:0016054 "biological_process:organic acid catabolic process" is_a: UPa:UPA00698 ! organic acid metabolism [Term] id: UPa:UPA00700 name: organic acid biosynthesis namespace: pathway def: "Biosynthesis of organic acids." [UPa:amorgat] xref: GO:0016053 "biological_process:organic acid biosynthetic process" is_a: UPa:UPA00698 ! organic acid metabolism [Term] id: UPa:UPA00701 name: lactate oxidation namespace: pathway def: "Oxidation of lactic acid." [UPa:amorgat] synonym: "lactic acid oxidation" EXACT [] xref: GO:0019516 "biological_process:lactate oxidation" is_a: UPa:UPA00498 ! metabolic intermediate degradation is_a: UPa:UPA00699 ! organic acid degradation relationship: uniprot_super_pathway UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00702 name: D-galactose 6-phosphate degradation namespace: pathway def: "Degradation of D-galactose 6-phosphate." [UPa:amorgat] synonym: "Leloir pathway" EXACT [] xref: GO:0019388 "biological_process:galactose catabolic process" xref: KEGG:map00052 "Galactose metabolism" xref: MetaCyc:LACTOSECAT-PWY is_a: UPa:UPA00214 ! galactose metabolism is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00703 name: glyoxylate cycle namespace: pathway def: "Glyoxylate cycle is a metabolic pathway occurring in plants, certain vertebrates, and several microorganisms, such as E. coli and yeast. The glyoxylate cycle allows these organisms to use fats for the synthesis of carbohydrates, a task which most vertebrates, including humans, cannot perform. The glyoxylate cycle, avoids the steps in the citric acid cycle (TCA cycle) where carbon is lost in the form of CO2. The two initial stages of this cycle are identical to those of the TCA cycle: acetate -> citrate -> isocitrate. The next step, however, is different: instead of decarboxylation, isocitrate undergoes cleavage into succinate and glyoxylate (the latter gives the cycle its name). Succinate can be channeled directly into the citric acid cycle and eventually form oxaloacetate. Glyoxylate condenses with acetyl-CoA, yielding malate. Both malate and oxaloacetate can be converted into phosphoenolpyruvate and gluconeogenesis can be initiated. The net result of the glyoxylate cycle is therefore the production of glucose from fatty acids. In plants the glyoxylate cycle occurs in special peroxisomes which are called glyoxysomes. Vertebrates cannot perform the cycle because they lack its two key enzymes: isocitrate lyase and malate synthase." [UPa:amorgat] synonym: "glyoxylate bypass" EXACT [] synonym: "glyoxylate shunt" EXACT [] xref: GO:0006097 "biological_process:glyoxylate cycle" xref: KEGG:map00020 "Citrate cycle (TCA cycle)" xref: KEGG:map00620 "Pyruvate metabolism" xref: KEGG:map00630 "Glyoxylate and dicarboxylate metabolism" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map00710 "Carbon fixation in photosynthetic organisms" xref: KEGG:map00720 "Carbon fixation pathways in prokaryotes" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:GLYOXYLATE-BYPASS xref: PMID:6378912 is_a: UPa:UPA00199 ! fatty acid metabolism is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00704 name: D-tagatose 6-phosphate degradation namespace: pathway def: "Degradation of D-tagatose 6-phosphate." [UPa:amorgat] xref: GO:2001059 "biological_process:D-tagatose 6-phosphate catabolic process" xref: KEGG:map00052 "Galactose metabolism" is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00705 name: oxidative phosphorylation namespace: pathway def: "Oxidative phosphorylation is a metabolic pathway that uses energy released by the oxidation of nutrients to produce adenosine triphosphate (ATP)." [UPa:amorgat] synonym: "respiratory-chain phosphorylation" EXACT [] xref: GO:0006119 "biological_process:oxidative phosphorylation" is_a: UPa:UPA00426 ! energy metabolism relationship: uniprot_super_pathway UPa:UPA00426 ! energy metabolism [Term] id: UPa:UPA00706 name: aromatic compound degradation namespace: pathway def: "Pathways involved in the degradation of aromatic compounds." [UPa:amorgat] xref: GO:0019439 "biological_process:aromatic compound catabolic process" is_a: UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00707 name: cresol metabolism namespace: pathway def: "Metabolism of cresols (methylphenols) organic compounds. They are a widely occurring natural and manufactured group of aromatic organic compounds which are categorized as phenols." [UPa:amorgat] synonym: "methylphenol metabolism" EXACT [] xref: GO:0042212 "biological_process:cresol metabolic process" is_a: UPa:UPA00433 ! aromatic compound metabolism is_a: UPa:UPA00611 ! alcohol metabolism [Term] id: UPa:UPA00708 name: p-cresol degradation namespace: pathway def: "Degradation of para-cresol, a toxic phenol." [UPa:amorgat] synonym: "para-cresol degradation" EXACT [] xref: GO:1901785 {source="rdfmatch"} xref: PMID:10623531 xref: PMID:1267796 is_a: UPa:UPA00612 ! alcohol degradation is_a: UPa:UPA00706 ! aromatic compound degradation is_a: UPa:UPA00707 ! cresol metabolism relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00709 name: flavonoid metabolism namespace: pathway def: "The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. [source: GO]." [UPa:amorgat] xref: GO:0009812 "biological_process:flavonoid metabolic process" is_a: UPa:UPA00710 ! phenylpropanoid metabolism [Term] id: UPa:UPA00710 name: phenylpropanoid metabolism namespace: pathway def: "Metabolism of phenylpropanoids, a group of compounds that are widely available in natural environments. Phenylpropanoids can originate from putrefaction of proteins in soil or as breakdown products of several constituents of plants, such as lignin, various oils, and resins." [UPa:amorgat] xref: GO:0009698 "biological_process:phenylpropanoid metabolic process" is_a: UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00711 name: phenylpropanoid biosynthesis namespace: pathway def: "Biosynthesis of phenylpropanoid compounds, the aromatic derivatives of trans-cinnamic acid." [UPa:amorgat] xref: GO:0009699 "biological_process:phenylpropanoid biosynthetic process" is_a: UPa:UPA00710 ! phenylpropanoid metabolism is_a: UPa:UPA00754 ! aromatic compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00712 name: phenylpropanoid degradation namespace: pathway def: "Microbial catabolism of phenylpropanoid compounds plays an important role not only in the natural degradative cycle of these aromatic molecules but also in their industrial applications such as wine making, aging, and storage." [UPa:amorgat] xref: GO:0046271 "biological_process:phenylpropanoid catabolic process" is_a: UPa:UPA00706 ! aromatic compound degradation is_a: UPa:UPA00710 ! phenylpropanoid metabolism [Term] id: UPa:UPA00713 name: trans-cinnamate biosynthesis namespace: pathway def: "Biosynthesis of cinnamic acid (3-phenyl-2-propenoic acid), a phenylpropanoid compound." [UPa:amorgat] synonym: "(E)-cinnamic acid biosynthesis" EXACT [] synonym: "3-phenyl-2-propenoic acid biosynthesis" EXACT [] synonym: "trans-cinnamic acid biosynthesis" EXACT [] xref: GO:0009800 "biological_process:cinnamic acid biosynthetic process" xref: KEGG:map00360 "Phenylalanine metabolism" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map00940 "Phenylpropanoid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00711 ! phenylpropanoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00710 ! phenylpropanoid metabolism [Term] id: UPa:UPA00714 name: 3-phenylpropanoate degradation namespace: pathway def: "Degradation of 3-phenylpropionic acid, a phenylpropanoid compound." [UPa:amorgat] synonym: "3-phenylpropionate degradation" EXACT [] synonym: "3-phenylpropionic acid degradation" EXACT [] xref: GO:0019380 "biological_process:3-phenylpropionate catabolic process" xref: KEGG:map00360 "Phenylalanine metabolism" xref: KEGG:map00362 "Benzoate degradation" xref: KEGG:map00621 "Dioxin degradation" xref: KEGG:map00622 "Xylene degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:9603882 is_a: UPa:UPA00712 ! phenylpropanoid degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00715 name: terpenoid degradation namespace: pathway def: "Degradation of terpene compounds." [UPa:amorgat] xref: GO:0046247 "biological_process:terpene catabolic process" is_a: UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00716 name: monoterpene metabolism namespace: pathway def: "Metabolism of monoterpene compoundss, terpenes with a C10 structure. [CHEBI:35187]." [UPa:amorgat] xref: GO:0043692 "biological_process:monoterpene metabolic process" is_a: UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00717 name: monoterpene biosynthesis namespace: pathway def: "Biosynthesis of monoterpene compounds, terpenes with a C10 structure." [UPa:amorgat] xref: GO:0043693 "biological_process:monoterpene biosynthetic process" is_a: UPa:UPA00716 ! monoterpene metabolism [Term] id: UPa:UPA00718 name: D-camphor metabolism namespace: pathway def: "Metabolism of D-camphor, a white, crystalline solid monoterpene ketone." [UPa:amorgat] synonym: "(+)-camphor metabolism" EXACT [] xref: GO:0018882 "biological_process:(+)-camphor metabolic process" is_a: UPa:UPA00716 ! monoterpene metabolism [Term] id: UPa:UPA00719 name: (R)-camphor degradation namespace: pathway def: "Degradation of (R)-camphor, a white, crystalline solid monoterpene ketone." [UPa:amorgat] synonym: "(+)-camphor degradation" EXACT [] synonym: "D-camphor degradation" EXACT [] xref: GO:0019383 "biological_process:(+)-camphor catabolic process" xref: MetaCyc:P601-PWY is_a: UPa:UPA00137 ! monoterpene degradation is_a: UPa:UPA00718 ! D-camphor metabolism relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00720 name: (R)-camphor biosynthesis namespace: pathway def: "Biosynthesis of (R)-camphor, a white, crystalline solid monoterpene ketone." [UPa:amorgat] synonym: "(+)-camphor biosynthesis" EXACT [] synonym: "D-camphor biosynthesis" EXACT [] xref: GO:0046211 "biological_process:(+)-camphor biosynthetic process" is_a: UPa:UPA00717 ! monoterpene biosynthesis is_a: UPa:UPA00718 ! D-camphor metabolism relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00721 name: linalool degradation namespace: pathway def: "Degradation of linalool, a naturally-occurring terpene alcohol compound found in many flowers and spice plants." [UPa:amorgat] synonym: "2,6-dimethyl-2,7-octadien-6-ol degradation" EXACT [] synonym: "allo-ocimenol degradation" EXACT [] synonym: "beta-linalool degradation" EXACT [] synonym: "linaloyl oxide degradation" EXACT [] synonym: "linalyl alcohol degradation" EXACT [] synonym: "p-linalool degradation" EXACT [] is_a: UPa:UPA00137 ! monoterpene degradation relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00722 name: steroid degradation namespace: pathway def: "Degradation of steroid compounds. A steroid is a terpenoid lipid characterized by a carbon skeleton with four fused rings, generally arranged in a 6-6-6-5 fashion. Steroids vary by the functional groups attached to these rings and the oxidation state of the rings. Hundreds of distinct steroids are found in plants, animals, and fungi. All steroids are made in cells either from the sterol lanosterol (animals and fungi) or the sterol cycloartenol (plants). Both sterols are derived from the cyclization of the triterpene squalene." [UPa:amorgat] xref: GO:0006706 "biological_process:steroid catabolic process" is_a: UPa:UPA00428 ! lipid degradation is_a: UPa:UPA00504 ! steroid metabolism is_a: UPa:UPA00715 ! terpenoid degradation relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00723 name: flavonoid degradation namespace: pathway def: "The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton. [source: GO]." [UPa:amorgat] xref: GO:0046275 "biological_process:flavonoid catabolic process" is_a: UPa:UPA00709 ! flavonoid metabolism is_a: UPa:UPA00712 ! phenylpropanoid degradation [Term] id: UPa:UPA00724 name: quercetin degradation namespace: pathway def: "Degradation of quercetin, the aglycone form of a number of other flavonoid glycosides." [UPa:amorgat] xref: GO:1901733 {source="rdfmatch"} xref: PMID:14741339 is_a: UPa:UPA00723 ! flavonoid degradation relationship: uniprot_super_pathway UPa:UPA00709 ! flavonoid metabolism [Term] id: UPa:UPA00725 name: scopolamine biosynthesis namespace: pathway def: "Biosynthesis of scopolamine (hyoscine), a tropane alkaloid compound with muscarinic antagonist effects. Scopolamine is obtained from plants of the family Solanaceae (nightshades), such as henbane or jimson weed (Datura species). It is among the secondary metabolites of these plants." [UPa:amorgat] synonym: "hyoscine biosynthesis" EXACT [] xref: GO:1900991 {source="rdfmatch"} is_a: UPa:UPA00330 ! tropane alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00726 name: phthalate degradation namespace: pathway def: "Degradation of phtalate (benzene-1,2-dicarboxylate)." [UPa:amorgat] synonym: "benzene-1,2-dicarboxylate degradation" EXACT [] synonym: "benzene-1,2-dicarboxylic acid degradation" EXACT [] xref: GO:0046239 "biological_process:phthalate catabolic process" xref: KEGG:map00624 "Polycyclic aromatic hydrocarbon degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00699 ! organic acid degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00727 name: coronatine biosynthesis namespace: pathway def: "Biosynthesis of coronatine, a phytotoxin produced by some plant-pathogenic bacteria. It has been shown that coronatine mimics the action of methyl jasmonate (MeJA) in plants. MeJA is a plant-signaling molecule involved in stress responses such as wounding and pathogen attack." [UPa:amorgat] is_a: UPa:UPA00477 ! phytotoxin biosynthesis relationship: uniprot_super_pathway UPa:UPA00477 ! phytotoxin biosynthesis [Term] id: UPa:UPA00728 name: phenol degradation namespace: pathway def: "Degradation of phenol." [UPa:amorgat] synonym: "hydroxybenzene" EXACT [] xref: GO:0019336 "biological_process:phenol-containing compound catabolic process" is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00729 name: 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis namespace: pathway def: "Biosynthesis of 2-methylthio-N-6-isopentenyl adenosine (ms2i6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs that read codons beginning with U except tRNA(i.v. Ser) in Escherichia coli. In Salmonella typhimurium, 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A; also referred to as 2-methylthio cis-ribozeatin) is found in tRNA, most likely in the species that have ms2i6A in E. coli." [UPa:amorgat] synonym: "2-methylthio-cis-ribozeatin-tRNA biosynthesis" EXACT [] synonym: "ms2io6A-tRNA biosynthesis" EXACT [] xref: GO:0002195 {source="rdfmatch"} xref: PMID:8253666 xref: PMID:9620964 is_a: UPa:UPA00481 ! tRNA modification relationship: uniprot_super_pathway UPa:UPA00481 ! tRNA modification [Term] id: UPa:UPA00730 name: carboxydiphenyl ether degradation namespace: pathway def: "Degradation of 3- and 4-carboxydiphenyl ether compounds." [UPa:amorgat] xref: PMID:7710319 is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00731 name: sabinene hydrate biosynthesis namespace: pathway def: "Biosynthesis of sabinene hydrate, a bicyclic monoterpene." [UPa:amorgat] xref: PMID:9614092 is_a: UPa:UPA00717 ! monoterpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00732 name: 4-aminobutanoate metabolism namespace: pathway def: "Metabolism of 4-aminobutanoate (GABA; gamma-aminobutyrate; 4-aminobutyrate)." [UPa:amorgat] synonym: "4-aminobutyrate metabolism" EXACT [] synonym: "GABA metabolism" EXACT [] synonym: "gamma-aminobutyrate metabolism" EXACT [] synonym: "gamma-aminobutyric acid metabolism" EXACT [] xref: GO:0009448 "biological_process:gamma-aminobutyric acid metabolic process" is_a: UPa:UPA00401 ! amino-acid metabolism [Term] id: UPa:UPA00733 name: 4-aminobutanoate degradation namespace: pathway def: "Degradation of 4-aminobutanoate (GABA; gamma-aminobutyrate; 4-aminobutyrate)." [UPa:amorgat] synonym: "4-aminobutyrate degradation" EXACT [] synonym: "GABA degradation" EXACT [] synonym: "gamma-aminobutyrate degradation" EXACT [] synonym: "gamma-aminobutyric acid degradation" EXACT [] xref: GO:0009450 "biological_process:gamma-aminobutyric acid catabolic process" xref: MetaCyc:4AMINOBUTMETAB-PWY is_a: UPa:UPA00699 ! organic acid degradation is_a: UPa:UPA00732 ! 4-aminobutanoate metabolism is_a: UPa:UPA00854 ! nonprotein amino-acid degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00734 name: acetylacetone degradation namespace: pathway def: "Degradation of the diketone acetylacetone (pentane-2,4-dione; 2,4-dioxopentane). Acetylacetone is a widely used industrial chemical with toxic side effects including central neurotoxicity and possible effects on the immune system of mammals, as well as toxicity towards various aquatic organisms and micro-organisms." [UPa:amorgat] synonym: "2,4-dioxopentane degradation" EXACT [] synonym: "pentane-2,4-dione degradation" EXACT [] xref: PMID:12379146 is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00410 ! ketone degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00735 name: opine metabolism namespace: pathway def: "Crown gall tumors and hairy roots are plant neoplasias induced by pathogenic members of the genus Agrobacterium. The transformed plant cells are characterized by low MW compounds called opines. The biosynthesis of these compounds is mediated by specific enzymes encoded by genes contained in a small segment of DNA (known as the T-DNA, for 'transfer DNA') inserted by the pathogen bacterium in the plant genome during infection. The opines produced by plant tumors serve as nutrient sources for the pathogenic agrobacteria. Each strain of Agrobacterium induces and catabolizes a specific set of opines." [UPa:amorgat] is_a: UPa:UPA00465 ! secondary metabolite metabolism [Term] id: UPa:UPA00736 name: mannopine biosynthesis namespace: pathway def: "Biosynthesis of mannopine (N-1-(D-mannityl)-L-glutamine), the head member of the mannityl family of opines. Mannopine is found in crown gall tumors." [UPa:amorgat] synonym: "N-1-(D-mannityl)-L-glutamine biosynthesis" EXACT [] xref: PMID:11386375 xref: PMID:1852015 is_a: UPa:UPA00735 ! opine metabolism relationship: uniprot_super_pathway UPa:UPA00735 ! opine metabolism [Term] id: UPa:UPA00737 name: octopine degradation namespace: pathway def: "Degradation of octopine (N2-(D-l-carboxyethyl)-L-arginine), the first opine discovered in 1927 in octopus muscle and later in crown gall tumors. It is also found in other cephalopod species and lamellibranchs. Octopine is the head member of the octopine family of opines." [UPa:amorgat] synonym: "N2-(D-l-carboxyethyl)-L-arginine degradation" EXACT [] xref: GO:0019469 "biological_process:octopine catabolic process" xref: PMID:8045881 is_a: UPa:UPA00735 ! opine metabolism relationship: uniprot_super_pathway UPa:UPA00735 ! opine metabolism [Term] id: UPa:UPA00738 name: 1,5-anhydro-D-fructose degradation namespace: pathway def: "Degradation of 1,5-anhydro-D-fructose." [UPa:amorgat] synonym: "1,5AnFru degradation" EXACT [] xref: GO:1901802 {source="rdfmatch"} xref: PMID:15716041 is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00739 name: benzoyl-CoA degradation namespace: pathway def: "Degradation of benzoyl-CoA. Many aromatic compounds are anaerobically oxidized to CO2 via benzoyl-CoA as the common aromatic intermediate." [UPa:amorgat] xref: GO:1901788 {source="rdfmatch"} xref: PMID:9746358 is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00740 name: 3-chloro-1,2-epoxypropane degradation namespace: pathway def: "Degradation of 3-chloro-1,2-epoxypropane." [UPa:amorgat] is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00741 name: glucosinolate biosynthesis namespace: pathway def: "Biosynthesis of glucosinolates, a class of organic compounds that contain sulfur, nitrogen and a group derived from glucose. Glucosinolates occur as secondary metabolites of many plants of the order Brassicales (especially in the family Brassicaceae, furthermore Capparidaceae and Caricaceae), but also in the genus Dryetes (family Euphorbiaceae). Plants use substances derived from glucosinolates as natural pesticides and as defense against herbivores." [UPa:amorgat] xref: GO:0019761 "biological_process:glucosinolate biosynthetic process" is_a: UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00742 name: phenylglucosinolate biosynthesis namespace: pathway def: "Biosynthesis of phenylglucosinolate." [UPa:amorgat] synonym: "phenyl-glucosinolate biosynthesis" EXACT [] is_a: UPa:UPA00741 ! glucosinolate biosynthesis relationship: uniprot_super_pathway UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00743 name: butanol biosynthesis namespace: pathway def: "Biosynthesis of butanol, a primary alcohol with a molecular formula of C4H10O. There are four isomeric structures for butanol. Clostridium acetobutylicum is one of the few organisms known to produce 1-butanol as a major fermentation product." [UPa:amorgat] xref: GO:0071271 "biological_process:1-butanol biosynthetic process" is_a: UPa:UPA00622 ! alcohol biosynthesis relationship: uniprot_super_pathway UPa:UPA00611 ! alcohol metabolism [Term] id: UPa:UPA00745 name: galactose biosynthesis namespace: pathway def: "Biosynthesis of galactose, the aldohexose galacto-hexose." [UPa:amorgat] xref: GO:0046369 "biological_process:galactose biosynthetic process" is_a: UPa:UPA00214 ! galactose metabolism is_a: UPa:UPA00412 ! carbohydrate biosynthesis relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00746 name: catecholamine biosynthesis namespace: pathway def: "Biosynthesis of catecholamines, a group of chemical compounds derived from the amino-acid tyrosine containing catechol and amine groups. The most abundant catecholamines are adrenaline (epinephrine), noradrenaline (norepinephrine) and dopamine." [UPa:amorgat] xref: GO:0042423 "biological_process:catecholamine biosynthetic process" is_a: UPa:UPA00289 ! amine and polyamine biosynthesis is_a: UPa:UPA00754 ! aromatic compound biosynthesis [Term] id: UPa:UPA00747 name: dopamine biosynthesis namespace: pathway def: "Biosynthesis of dopamine (DA; 4-(2-aminoethyl)benzene-1,2-diol), a catecholamine neurotransmitter and a metabolic precursor of adrenaline (epinephrine), noradrenaline (norepinephrine)." [UPa:amorgat] synonym: "4-(2-aminoethyl)benzene-1,2-diol biosynthesis" EXACT [] synonym: "DA biosynthesis" EXACT [] xref: GO:0042416 "biological_process:dopamine biosynthetic process" xref: KEGG:map00350 "Tyrosine metabolism" xref: KEGG:map00950 "Isoquinoline alkaloid biosynthesis" xref: KEGG:map00965 "Betalain biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00746 ! catecholamine biosynthesis relationship: uniprot_super_pathway UPa:UPA00746 ! catecholamine biosynthesis [Term] id: UPa:UPA00748 name: (R)-noradrenaline biosynthesis namespace: pathway def: "Biosynthesis of L-noradrenaline (norepinephrine), an hormone produced by the medulla of the adrenal glands." [UPa:amorgat] synonym: "L-noradrenaline biosynthesis" EXACT [] xref: GO:0042421 "biological_process:norepinephrine biosynthetic process" xref: KEGG:map00350 "Tyrosine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00746 ! catecholamine biosynthesis relationship: uniprot_super_pathway UPa:UPA00746 ! catecholamine biosynthesis [Term] id: UPa:UPA00749 name: (R)-adrenaline biosynthesis namespace: pathway def: "Biosynthesis of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [UPa:amorgat] synonym: "adrenaline biosynthesis" EXACT [] xref: GO:0042418 "biological_process:epinephrine biosynthetic process" xref: KEGG:map00350 "Tyrosine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00746 ! catecholamine biosynthesis relationship: uniprot_super_pathway UPa:UPA00746 ! catecholamine biosynthesis [Term] id: UPa:UPA00750 name: catechol degradation namespace: pathway def: "Degradation of catechol (1,2-dihydroxybenzene)." [UPa:amorgat] synonym: "1,2-dihydroxybenzene degradation" EXACT [] synonym: "o-benzenediol degradation" EXACT [] synonym: "pyrocatechol degradation" EXACT [] xref: GO:0019614 "biological_process:catechol-containing compound catabolic process" is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00751 name: phospholipid biosynthesis namespace: pathway def: "Biosynthesis of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [UPa:amorgat] xref: GO:0008654 "biological_process:phospholipid biosynthetic process" is_a: UPa:UPA00085 ! phospholipid metabolism [Term] id: UPa:UPA00752 name: phospholipid degradation namespace: pathway def: "Degradation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [UPa:amorgat] xref: GO:0009395 "biological_process:phospholipid catabolic process" is_a: UPa:UPA00085 ! phospholipid metabolism [Term] id: UPa:UPA00753 name: phosphatidylcholine biosynthesis namespace: pathway def: "Biosynthesis of phosphatidylcholine, also called lecithin, a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. Phosphatidylcholine is the most-abundant phospholipid found in eukaryotic membranes. Additionally to its structural function in membrane bilayers and lipoproteins, phosphatidylcholine is involved in many signal transduction pathways. Phosphatidylcholine has also been found in an increasing number of bacteria, in particular in species that interact with eukaryotic hosts." [UPa:amorgat] synonym: "1,2-diacyl-sn-glycero-3-phosphocholine biosynthesis" EXACT [] synonym: "lecithin biosynthesis" EXACT [] xref: GO:0006656 "biological_process:phosphatidylcholine biosynthetic process" xref: KEGG:map00564 "Glycerophospholipid metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:14663079 xref: PMID:18978052 is_a: UPa:UPA00947 ! glycerophospholipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00085 ! phospholipid metabolism [Term] id: UPa:UPA00754 name: aromatic compound biosynthesis namespace: pathway def: "Biosynthesis of aromatic compounds." [UPa:amorgat] xref: GO:0019438 "biological_process:aromatic compound biosynthetic process" is_a: UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00755 name: chondroitin sulfate biosynthesis namespace: pathway def: "Biosynthesis of chondroitin sulfate, a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid). It is usually found attached to proteins as part of a proteoglycan." [UPa:amorgat] xref: GO:0030206 "biological_process:chondroitin sulfate biosynthetic process" is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00756 name: heparan sulfate biosynthesis namespace: pathway def: "Biosynthesis of heparan sulfate (HS), a linear polysaccharide found in all animal tissues. Heparan sulfate is a member of the glycosaminoglycan family of carbohydrates and is very closely related in structure to heparin. The most common disaccharide unit within heparan sulfate is composed of a glucuronic (GlcA) linked to N-acetylglucosamine (GlcNAc) typically making up around 50% of the total disaccharide units. It is usually found attached to proteins as part of a proteoglycan." [UPa:amorgat] xref: GO:0015012 "biological_process:heparan sulfate proteoglycan biosynthetic process" xref: PMID:11121397 xref: PMID:11274177 is_a: UPa:UPA00861 ! glycosaminoglycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00757 name: dhurrin biosynthesis namespace: pathway def: "Biosynthesis of dhurrin, a tyrosine derived cyanogenic glucoside. Dhurrin functions as a plant defense compound. Cyanogenic glucosides are amino-acid-derived natural products. The ability to synthesize these glucosides is common across many plant genera, including several plant species that are important crop plants like sorghum (Sorghum bicolor), cassava (Manihot esculenta), flax (Linum usitatissimum) and almonds (Prunus dulcis)." [UPa:amorgat] synonym: "(S)-4-hydroxymandelonitrile beta-D-glucoside" EXACT [] xref: GO:0010132 "biological_process:dhurrin biosynthetic process" xref: KEGG:map00460 "Cyanoamino acid metabolism" xref: KEGG:map00966 "Glucosinolate biosynthesis" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: MetaCyc:PWY-861 xref: PMID:10585420 xref: PMID:11312134 xref: PMID:17706731 is_a: UPa:UPA00412 ! carbohydrate biosynthesis is_a: UPa:UPA00464 ! secondary metabolite biosynthesis relationship: uniprot_super_pathway UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00758 name: nucleotide degradation namespace: pathway def: "Degradation of nucleotides." [UPa:amorgat] xref: GO:0009166 "biological_process:nucleotide catabolic process" is_a: UPa:UPA00486 ! nucleotide metabolism [Term] id: UPa:UPA00759 name: cyclic nucleotide metabolism namespace: pathway def: "Biosynthesis of cyclic nucleotides, any nucleotide in which the phosphate group is bonded to two of the sugar's hydroxyl groups, forming a cyclical or ring structure. Examples: cAMP, cGMP, c-di-GMP, etc." [UPa:amorgat] xref: GO:0009187 "biological_process:cyclic nucleotide metabolic process" is_a: UPa:UPA00486 ! nucleotide metabolism [Term] id: UPa:UPA00760 name: cyclic nucleotide degradation namespace: pathway def: "Degradation of cyclic nucleotides, any nucleotide in which the phosphate group is bonded to two of the sugar's hydroxyl groups, forming a cyclical or ring structure. Examples: cAMP, cGMP, c-di-GMP, etc." [UPa:amorgat] xref: GO:0009214 "biological_process:cyclic nucleotide catabolic process" is_a: UPa:UPA00758 ! nucleotide degradation is_a: UPa:UPA00759 ! cyclic nucleotide metabolism [Term] id: UPa:UPA00761 name: purine nucleotide degradation namespace: pathway def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety [source: GO]." [UPa:amorgat] xref: GO:0006195 "biological_process:purine nucleotide catabolic process" is_a: UPa:UPA00210 ! purine nucleotide metabolism is_a: UPa:UPA00585 ! purine degradation [Term] id: UPa:UPA00762 name: 3',5'-cyclic AMP degradation namespace: pathway def: "Degradation of cAMP into AMP." [UPa:amorgat] synonym: "3',5'-cAMP degradation" EXACT [] synonym: "adenosine 3',5'-cyclophosphate degradation" EXACT [] synonym: "cyclic AMP degradation" EXACT [] xref: GO:0006198 "biological_process:cAMP catabolic process" xref: KEGG:map00230 "Purine metabolism" is_a: UPa:UPA00760 ! cyclic nucleotide degradation is_a: UPa:UPA00761 ! purine nucleotide degradation relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00763 name: 3',5'-cyclic GMP degradation namespace: pathway def: "Degradation of cyclic GMP nucleotide into GMP." [UPa:amorgat] synonym: "3',5'-cGMP degradation" EXACT [] synonym: "cyclic GMP degradation" EXACT [] synonym: "guanosine 3',5'-cyclophosphate degradation" EXACT [] xref: GO:0046069 "biological_process:cGMP catabolic process" xref: KEGG:map00230 "Purine metabolism" is_a: UPa:UPA00760 ! cyclic nucleotide degradation is_a: UPa:UPA00761 ! purine nucleotide degradation relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00764 name: cyclopentanol degradation namespace: pathway def: "Degradation of cyclopentanol, a cyclic alcohol." [UPa:amorgat] xref: GO:0033022 "biological_process:cyclopentanol catabolic process" xref: PMID:12406764 is_a: UPa:UPA00612 ! alcohol degradation relationship: uniprot_super_pathway UPa:UPA00611 ! alcohol metabolism [Term] id: UPa:UPA00765 name: ecdysteroid biosynthesis namespace: pathway def: "Biosynthesis of ecdysteroid compounds, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. [source: GO]." [UPa:amorgat] synonym: "ecdysteroidogenesis" EXACT [] synonym: "ecdysteroidogenic pathway" EXACT [] xref: GO:0045456 "biological_process:ecdysteroid biosynthetic process" is_a: UPa:UPA00062 ! steroid biosynthesis relationship: uniprot_super_pathway UPa:UPA00062 ! steroid biosynthesis [Term] id: UPa:UPA00766 name: sterol biosynthesis namespace: pathway def: "Biosynthesis of sterol compounds (steroid alcohols), a subgroup of steroids with a hydroxyl group in the 3-position of the A-ring." [UPa:amorgat] xref: GO:0016126 "biological_process:sterol biosynthetic process" is_a: UPa:UPA00062 ! steroid biosynthesis is_a: UPa:UPA00622 ! alcohol biosynthesis relationship: uniprot_super_pathway UPa:UPA00062 ! steroid biosynthesis [Term] id: UPa:UPA00767 name: lanosterol biosynthesis namespace: pathway def: "Biosynthesis of lanosterol, a tetracyclic triterpenoid precursor to the whole family of steroids." [UPa:amorgat] xref: KEGG:map00100 "Steroid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00062 ! steroid biosynthesis relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00768 name: ergosterol biosynthesis namespace: pathway def: "Biosynthesis of ergosterol (ergosta-5,7,22-trien-3beta-ol) from zymosterol. Ergosterol is a sterol precursor to Vitamin D2 compounds." [UPa:amorgat] xref: KEGG:map00100 "Steroid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:ERGOSTEROL-SYN-PWY is_a: UPa:UPA00766 ! sterol biosynthesis relationship: uniprot_super_pathway UPa:UPA00504 ! steroid metabolism [Term] id: UPa:UPA00769 name: estrogen biosynthesis namespace: pathway def: "Biosynthesis of estrogen (oestrogen) compounds, a group of steroid compounds, named for their importance in the estrous cycle, and functioning as the primary female sex hormone." [UPa:amorgat] synonym: "oestrogen biosynthesis" EXACT [] xref: GO:0006703 "biological_process:estrogen biosynthetic process" is_a: UPa:UPA00440 ! steroid hormone biosynthesis relationship: uniprot_super_pathway UPa:UPA00062 ! steroid biosynthesis [Term] id: UPa:UPA00770 name: zymosterol biosynthesis namespace: pathway def: "Biosynthesis of zymosterol (5alpha-cholesta-8,24-dien-3beta-ol), a sterol precursor to cholesterol or ergosterol." [UPa:amorgat] synonym: "5alpha-cholesta-8,24-dien-3beta-ol biosynthesis" EXACT [] synonym: "delta8,24-cholestadien-3beta-ol biosynthesis" EXACT [] xref: KEGG:map00100 "Steroid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00766 ! sterol biosynthesis relationship: uniprot_super_pathway UPa:UPA00062 ! steroid biosynthesis [Term] id: UPa:UPA00771 name: D-erythroascorbate biosynthesis namespace: pathway def: "D-erythroascorbate (EASC), a five-carbon analog of L-ascorbate (ASC) is present in some eukaryotic microorganisms where ASC is rare or absent. In Candida albicans and Saccharomyces cerevisiae, the biosynthetic pathway of EASC from D-arabinose by D-arabinose dehydrogenase and D-arabinono-1,4-lactone oxidase has been established. EASC has biological properties similar to those of ASC. Considering that some eukaryotic microorganisms produce EASC instead of ASC, it is presumed that EASC may take the place of ASC in these microorganisms. EASC has been proved an important antioxidant molecule in S. cerevisiae, like ASC in animals and plants." [UPa:amorgat] synonym: "D-erythroascorbic acid biosynthesis" EXACT [] synonym: "EASC biosynthesis" EXACT [] xref: PMID:10094636 xref: PMID:11349062 xref: PMID:7957197 xref: PMID:8841374 xref: PMID:9920381 is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00412 ! carbohydrate biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00772 name: decaprenyl phosphate biosynthesis namespace: pathway def: "Biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan." [UPa:amorgat] xref: PMID:10816587 xref: PMID:11152452 is_a: UPa:UPA00751 ! phospholipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00085 ! phospholipid metabolism [Term] id: UPa:UPA00773 name: epidermin biosynthesis namespace: pathway def: "Biosynthesis of epidermin, a type A lantibiotics that is is ribosomally synthesized and post-translationally modified. Extracellular proteolytic cleavage of the N-terminal leader region is most likely the last modification step in epidermin biosynthesis and leads to the activation of the lantibiotic." [UPa:amorgat] xref: PMID:12732329 xref: PMID:1551392 xref: PMID:1740156 is_a: UPa:UPA00471 ! lantibiotic A biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00774 name: epothilone biosynthesis namespace: pathway def: "Biosynthesis of epothilone compounds, a class of macrolactone cytotoxic molecules, including epothilone A, epothilone B, and epothilone D, identified as potential chemotherapy drugs." [UPa:amorgat] xref: GO:0050814 "biological_process:epothilone biosynthetic process" is_a: UPa:UPA00464 ! secondary metabolite biosynthesis relationship: uniprot_super_pathway UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00775 name: alkene degradation namespace: pathway def: "Degradation of alkene compounds, unsaturated hydrcarbons containing at least one carbon-to-carbon double bond. Some bacteria, such as Xanthobacter autotrophicus Py2 and Rhodococcus rhodochrous, are capable of aerobic growth using aliphatic alkenes (such as ethylene, propylene and butylene) as source of carbon and energy." [UPa:amorgat] synonym: "olefin degradation" EXACT [] xref: GO:0043451 "biological_process:alkene catabolic process" is_a: UPa:UPA00352 ! hydrocarbon degradation is_a: UPa:UPA00777 ! alkene metabolism [Term] id: UPa:UPA00776 name: propylene degradation namespace: pathway def: "Degradation of alkene compounds, unsaturated hydrcarbons containing at least one carbon-to-carbon double bond." [UPa:amorgat] synonym: "propene degradation" EXACT [] xref: GO:0042208 "biological_process:propylene catabolic process" xref: MetaCyc:PWY-5534 is_a: UPa:UPA00352 ! hydrocarbon degradation relationship: uniprot_super_pathway UPa:UPA00777 ! alkene metabolism [Term] id: UPa:UPA00777 name: alkene metabolism namespace: pathway def: "Metabolism of alkene compounds, unsaturated hydrocarbons containing at least one carbon-to-carbon double bond." [UPa:amorgat] synonym: "olefin metabolism" EXACT [] xref: GO:0043449 "biological_process:cellular alkene metabolic process" is_a: UPa:UPA00325 ! hydrocarbon metabolism [Term] id: UPa:UPA00778 name: ethanol biosynthesis via fermentation pathway namespace: pathway def: "Biosynthesis of ethanol during fermentation processes." [UPa:amorgat] xref: GO:0043458 "biological_process:ethanol biosynthetic process involved in glucose fermentation to ethanol" is_a: UPa:UPA00553 ! fermentation is_a: UPa:UPA00622 ! alcohol biosynthesis is_a: UPa:UPA00779 ! ethanol metabolism relationship: uniprot_super_pathway UPa:UPA00611 ! alcohol metabolism [Term] id: UPa:UPA00779 name: ethanol metabolism namespace: pathway def: "Metabolism of ethanol." [UPa:amorgat] xref: GO:0006067 "biological_process:ethanol metabolic process" is_a: UPa:UPA00611 ! alcohol metabolism [Term] id: UPa:UPA00780 name: ethanol degradation namespace: pathway def: "Degradation of ethanol." [UPa:amorgat] xref: GO:0006068 "biological_process:ethanol catabolic process" xref: KEGG:map00010 "Glycolysis / Gluconeogenesis" xref: KEGG:map00620 "Pyruvate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00612 ! alcohol degradation is_a: UPa:UPA00779 ! ethanol metabolism relationship: uniprot_super_pathway UPa:UPA00611 ! alcohol metabolism [Term] id: UPa:UPA00781 name: ether lipid biosynthesis namespace: pathway def: "Biosynthesis of ether lipid compounds. Ether lipids are lipids in which one or more of the carbon atoms on glycerol is bonded to an alkyl chain via an ether linkage, as opposed to the usual ester linkage." [UPa:amorgat] xref: GO:0008611 "biological_process:ether lipid biosynthetic process" is_a: UPa:UPA00495 ! glycerolipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00230 ! glycerolipid metabolism [Term] id: UPa:UPA00782 name: Fe-Mo cofactor biosynthesis namespace: pathway def: "Biosynthesis of Fe-Mo, the cofactor of nitrogenase (iron-molybdenum cofactor; FeMo-co). Fe-Mo cofactor is synthesized in a multistep process catalysed by several Nif proteins and is finally inserted into a pre-synthesized apo-dinitrogenase to generate mature dinitrogenase protein." [UPa:amorgat] synonym: "FeMo-co biosynthesis" EXACT [] synonym: "iron-molybdenum cofactor biosynthesis" EXACT [] xref: GO:1901288 {source="rdfmatch"} xref: PMID:17163967 xref: PMID:3470285 is_a: UPa:UPA00399 ! cofactor biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00783 name: ferrichrome biosynthesis namespace: pathway def: "Biosynthesis of siderophore ferrichrome." [UPa:amorgat] xref: GO:0031169 "biological_process:ferrichrome biosynthetic process" xref: PMID:11395469 xref: PMID:8430103 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00784 name: fructoselysine degradation namespace: pathway def: "Degradation of fructolysine, a fructose molecule containing a lysine moiety in place of an hydroxyl group. Escherichia coli was found to grow on fructoselysine as an energetic substrate at a rate of about one-third of that observed with glucose." [UPa:amorgat] xref: PMID:12147680 is_a: UPa:UPA00413 ! carbohydrate degradation is_a: UPa:UPA00427 ! amino-acid degradation relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00785 name: melanin biosynthesis namespace: pathway def: "Biosynthesis of melanin, any of the polyacetylene, polyaniline, and polypyrrole 'blacks' and 'browns' or their mixed copolymers. The most common form of biological melanin is a polymer of either or both of two monomer molecules: indolequinone, and dihydroxyindole carboxylic acid. Melanin exists in the plant, animal and protista kingdoms, where it serves as a pigment. The presence of melanin in the archaea and bacteria kingdoms is still an issue." [UPa:amorgat] xref: GO:0042438 "biological_process:melanin biosynthetic process" is_a: UPa:UPA00499 ! pigment biosynthesis relationship: uniprot_super_pathway UPa:UPA00499 ! pigment biosynthesis [Term] id: UPa:UPA00786 name: sphingolipid biosynthesis namespace: pathway def: "Biosynthesis of sphingolipid compounds, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). There are three main types of sphingolipids: ceramides, sphingomyelins and glycosphingolipids." [UPa:amorgat] xref: GO:0030148 "biological_process:sphingolipid biosynthetic process" is_a: UPa:UPA00222 ! sphingolipid metabolism is_a: UPa:UPA00938 ! membrane lipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00939 ! membrane lipid metabolism [Term] id: UPa:UPA00787 name: galactosylceramide biosynthesis namespace: pathway def: "Biosynthesis of the sphingolipid compounds: galactosylceramide (galactocerebroside)." [UPa:amorgat] synonym: "D-galactosyl-N-acylsphingosine" EXACT [] synonym: "galactocerebroside biosynthesis" EXACT [] xref: GO:0006682 "biological_process:galactosylceramide biosynthetic process" is_a: UPa:UPA00786 ! sphingolipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00222 ! sphingolipid metabolism [Term] id: UPa:UPA00788 name: glucocorticoid biosynthesis namespace: pathway def: "Biosynthesis of glucocorticoid compounds, a class of steroid hormones (corticosteroids) characterised by an ability to bind with the glucocorticoid receptor (GR)." [UPa:amorgat] xref: GO:0006704 "biological_process:glucocorticoid biosynthetic process" is_a: UPa:UPA00440 ! steroid hormone biosynthesis relationship: uniprot_super_pathway UPa:UPA00062 ! steroid biosynthesis [Term] id: UPa:UPA00789 name: poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis namespace: pathway def: "Biosynthesis of poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid." [UPa:amorgat] synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) TA biosynthesis" EXACT [] is_a: UPa:UPA00632 ! teichoic acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00547 ! cell wall biogenesis [Term] id: UPa:UPA00790 name: poly(ribitol phosphate) teichoic acid biosynthesis namespace: pathway def: "Biosynthesis of poly(ribitol phosphate) teichoic acid." [UPa:amorgat] synonym: "poly(ribitol phosphate) TA biosynthesis" EXACT [] xref: GO:1902012 {source="rdfmatch"} is_a: UPa:UPA00632 ! teichoic acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00547 ! cell wall biogenesis [Term] id: UPa:UPA00791 name: aldonic acid degradation namespace: pathway def: "Degradation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [UPa:amorgat] xref: GO:0046176 "biological_process:aldonic acid catabolic process" is_a: UPa:UPA00858 ! carbohydrate acid degradation [Term] id: UPa:UPA00792 name: D-gluconate degradation namespace: pathway def: "Degradation of D-gluconic acid." [UPa:amorgat] synonym: "gluconate utilization system GNT-I" EXACT [] xref: GO:0046177 "biological_process:D-gluconate catabolic process" is_a: UPa:UPA00791 ! aldonic acid degradation relationship: uniprot_super_pathway UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA00793 name: L-idonate degradation namespace: pathway def: "Degradation of L-idonate. The pathway for catabolism of L-idonate, which proceeds via a D-gluconate intermediate, was originally thought to be gluconate utilization system GntII." [UPa:amorgat] synonym: "gluconate utilization system GNT-II" EXACT [] xref: GO:0046183 "biological_process:L-idonate catabolic process" xref: PMID:14973046 is_a: UPa:UPA00791 ! aldonic acid degradation relationship: uniprot_super_pathway UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA00794 name: aldaric acid degradation namespace: pathway def: "Degradation of aldaric acids, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [UPa:amorgat] xref: GO:0019579 "biological_process:aldaric acid catabolic process" is_a: UPa:UPA00858 ! carbohydrate acid degradation [Term] id: UPa:UPA00795 name: glucosylglycerol biosynthesis namespace: pathway def: "Biosynthesis of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [UPa:amorgat] synonym: "alpha-D-glucopyranosyl-alpha-(1,2)-glycerol biosynthesis" EXACT [] xref: GO:0051473 "biological_process:glucosylglycerol biosynthetic process" is_a: UPa:UPA00484 ! glycan biosynthesis is_a: UPa:UPA00615 ! glycerol metabolism relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00796 name: UDP-alpha-D-xylose biosynthesis namespace: pathway def: "Biosynthesis of UDP-D-xylose, a nucleotide sugar used to initiate glycosaminoglycan biosynthesis on the core protein of proteoglycans." [UPa:amorgat] xref: GO:0033320 "biological_process:UDP-D-xylose biosynthetic process" xref: KEGG:map00500 "Starch and sucrose metabolism" xref: KEGG:map00520 "Amino sugar and nucleotide sugar metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:11877387 is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00797 name: UDP-L-arabinose biosynthesis namespace: pathway def: "Biosynthesis of the nucleotide sugar, UDP-arabinose." [UPa:amorgat] xref: GO:0033358 "biological_process:UDP-L-arabinose biosynthetic process" xref: KEGG:map00520 "Amino sugar and nucleotide sugar metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:12566589 is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00798 name: zeaxanthin diglucoside biosynthesis namespace: pathway def: "Biosynthesis of zeaxanthin diglucoside, a glycosylated xantophyll carotenoid." [UPa:amorgat] xref: GO:1901830 {source="rdfmatch"} is_a: UPa:UPA00419 ! xantophyll biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00799 name: phytoene biosynthesis namespace: pathway def: "Biosynthesis of phytoene, an acyclic carotene precursor to carotenoids." [UPa:amorgat] xref: KEGG:map00906 "Carotenoid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00418 ! carotene biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00800 name: neurosporene biosynthesis namespace: pathway def: "Biosynthesis of neurosporene, a carotene compound." [UPa:amorgat] is_a: UPa:UPA00418 ! carotene biosynthesis [Term] id: UPa:UPA00801 name: delta-carotene biosynthesis namespace: pathway def: "Biosynthesis of delta-carotene, a cyclic carotene compound." [UPa:amorgat] xref: GO:1901824 {source="rdfmatch"} is_a: UPa:UPA00418 ! carotene biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00802 name: beta-carotene biosynthesis namespace: pathway def: "Biosynthesis of beta-carotene, a cyclic carotene compound." [UPa:amorgat] xref: GO:1901812 {source="rdfmatch"} is_a: UPa:UPA00418 ! carotene biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00803 name: lycopene biosynthesis namespace: pathway def: "Biosynthesis of lycopene, a bright red carotenoid pigment found in tomatoes and other red fruits." [UPa:amorgat] xref: GO:1901177 {source="rdfmatch"} is_a: UPa:UPA00418 ! carotene biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00804 name: alpha-zeacarotene biosynthesis namespace: pathway def: "Biosynthesis of alpha-zeacarotene, a cyclic carotene compound." [UPa:amorgat] xref: GO:1901821 {source="rdfmatch"} is_a: UPa:UPA00418 ! carotene biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00805 name: beta-zeacarotene biosynthesis namespace: pathway def: "Biosynthesis of beta-zeacarotene, a cyclic carotene compound." [UPa:amorgat] xref: GO:1901818 {source="rdfmatch"} is_a: UPa:UPA00418 ! carotene biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00806 name: capsanthin biosynthesis namespace: pathway def: "Biosynthesis of capsanthin, a xantophyll carotenoid." [UPa:amorgat] xref: GO:1901809 {source="rdfmatch"} xref: KEGG:map00906 "Carotenoid biosynthesis" is_a: UPa:UPA00419 ! xantophyll biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00807 name: capsorubin biosynthesis namespace: pathway def: "Biosynthesis of capsorubin, a xantophyll carotenoid." [UPa:amorgat] xref: GO:1901866 {source="rdfmatch"} xref: KEGG:map00906 "Carotenoid biosynthesis" is_a: UPa:UPA00419 ! xantophyll biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00808 name: dibenzofuran degradation namespace: pathway def: "Degradation of dibenzofuran. Dibenzofuran is created as by-products during industrial processes such as incineration, paper bleaching, and chemical synthesis. It has also been used as an insecticide, and is formed from the photolysis of chlorinated biphenyl ethers. Several species of bacteria capable degrading dibenzofuran have been identified, including Pseudomonas, Xanthomonas, Terrabacter, Microbacterium, and Rhodococcus." [UPa:amorgat] xref: GO:0019340 "biological_process:dibenzofuran catabolic process" xref: KEGG:map00621 "Dioxin degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:P662-PWY xref: PMID:8226678 xref: PMID:8981980 is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00809 name: dibenzo-p-dioxin degradation namespace: pathway def: "Degradation of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxin is created as by-products during industrial processes such as incineration, paper bleaching, and chemical synthesis." [UPa:amorgat] xref: GO:0019341 "biological_process:dibenzo-p-dioxin catabolic process" xref: KEGG:map00621 "Dioxin degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:P661-PWY is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00810 name: D-xylose degradation namespace: pathway def: "Degradation of D-xylose, a naturally occurring plant polysaccharide." [UPa:amorgat] xref: GO:0042843 "biological_process:D-xylose catabolic process" is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00811 name: Vi-antigen biosynthesis namespace: pathway def: "Biosynthesis of Vi antigen, a capsular polysaccharide expressed by Salmonella typhi, the agent of human typhoid fever." [UPa:amorgat] is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00812 name: D-sorbitol degradation namespace: pathway def: "Degradation of sorbitol, one of the ten stereoisomeric hexitols." [UPa:amorgat] synonym: "D-glucitol degradation" EXACT [] xref: GO:0006062 "biological_process:sorbitol catabolic process" xref: KEGG:map00051 "Fructose and mannose metabolism" xref: MetaCyc:SORBDEG-PWY is_a: UPa:UPA00413 ! carbohydrate degradation is_a: UPa:UPA00612 ! alcohol degradation relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00813 name: aldonic acid biosynthesis namespace: pathway def: "Biosynthesis of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [UPa:amorgat] xref: GO:0046175 "biological_process:aldonic acid biosynthetic process" is_a: UPa:UPA00859 ! carbohydrate acid biosynthesis [Term] id: UPa:UPA00814 name: D-gluconate biosynthesis namespace: pathway def: "Biosynthesis of D-gluconic acid, an aldonic acid." [UPa:amorgat] xref: GO:0046178 "biological_process:D-gluconate biosynthetic process" xref: KEGG:map00030 "Pentose phosphate pathway" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00813 ! aldonic acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA00815 name: D-sorbitol biosynthesis namespace: pathway def: "Biosynthesis of sorbitol, one of the ten stereoisomeric hexitols." [UPa:amorgat] synonym: "D-glucitol biosynthesis" EXACT [] xref: GO:0006061 "biological_process:sorbitol biosynthetic process" xref: MetaCyc:PWY-5530 is_a: UPa:UPA00412 ! carbohydrate biosynthesis is_a: UPa:UPA00622 ! alcohol biosynthesis relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00816 name: dTDP-6-deoxy-L-altrose biosynthesis namespace: pathway def: "Biosynthesis of dTDP-6-deoxy-L-altrose, a nucleotide sugar." [UPa:amorgat] xref: PMID:7692217 is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00817 name: dTDP-4-acetamido-4,6-dideoxygalactose biosynthesis namespace: pathway def: "Biosynthesis of dTDP-4-acetamido-4,6-dideoxygalactose (dTDP-D-Fuc4NAc), a nucleotide sugar." [UPa:amorgat] synonym: "dTDP-D-Fuc4NAc biosynthesis" EXACT [] xref: PMID:7559340 is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00818 name: CDP-ascarylose biosynthesis namespace: pathway def: "Biosynthesis of CDP-ascarylose, one of the naturally occurring 3,6-dideoxyhexoses usually confined to the cell wall lipopolysaccharide of gram-negative bacteria." [UPa:amorgat] xref: PMID:8288541 is_a: UPa:UPA00304 ! nucleotide-sugar biosynthesis relationship: uniprot_super_pathway UPa:UPA00304 ! nucleotide-sugar biosynthesis [Term] id: UPa:UPA00819 name: spermidine metabolism namespace: pathway def: "Metabolism of spermidine polyamine." [UPa:amorgat] xref: GO:0008216 "biological_process:spermidine metabolic process" is_a: UPa:UPA00455 ! amine and polyamine metabolism relationship: uniprot_super_pathway UPa:UPA00455 ! amine and polyamine metabolism [Term] id: UPa:UPA00820 name: lacto-N-neotetraose biosynthesis namespace: pathway def: "Biosynthesis of lacto-N-neotetraose, an oligosaccharide found in the terminal position of lipooligosaccharide of Neisseria meningitidis." [UPa:amorgat] is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00821 name: exopolysaccharide EPS I biosynthesis namespace: pathway def: "Biosynthesis of exopolysaccharide EPS I." [UPa:amorgat] synonym: "EPS I biosynthesis" EXACT [] xref: PMID:7476194 xref: PMID:8626297 is_a: UPa:UPA00631 ! exopolysaccharide biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00822 name: histamine biosynthesis namespace: pathway def: "Biosynthesis of histamine (2-(4-imidazolyl)ethylamine). This physiologically active amine is derived from the decarboxylation of the amino-acid histidine, a reaction catalyzed by the enzyme L-histidine decarboxylase." [UPa:amorgat] synonym: "2-(4-imidazolyl)ethylamine biosynthesis" EXACT [] xref: GO:0001694 "biological_process:histamine biosynthetic process" xref: KEGG:map00340 "Histidine metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:15612036 xref: PMID:2216786 is_a: UPa:UPA00289 ! amine and polyamine biosynthesis is_a: UPa:UPA00490 ! histidine metabolism relationship: uniprot_super_pathway UPa:UPA00289 ! amine and polyamine biosynthesis [Term] id: UPa:UPA00823 name: myo-inositol biosynthesis namespace: pathway def: "Biosynthesis of myo-inositol (cis-1,2,3,5-trans-4,6-cyclohexanehexol), arbocyclic polyol that plays an important role as the structural basis for a number of secondary messengers in eukaryotic cells, including inositol phosphates, phosphatidylinositol (PI) and phosphatidylinositol phosphate (PIP) lipids." [UPa:amorgat] xref: GO:0006021 "biological_process:inositol biosynthetic process" xref: KEGG:map00521 "Streptomycin biosynthesis" xref: KEGG:map00562 "Inositol phosphate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map04070 "Phosphatidylinositol signaling system" xref: MetaCyc:PWY-2301 is_a: UPa:UPA00623 ! polyol biosynthesis is_a: UPa:UPA00914 ! myo-inositol metabolism relationship: uniprot_super_pathway UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00824 name: salicylate degradation namespace: pathway def: "Degradation of salicylic acid, an intermediate in degradation of phenol and naphtalene compounds." [UPa:amorgat] synonym: "UPC00805 meta-cleavage pathway" EXACT [] xref: GO:0046244 "biological_process:salicylic acid catabolic process" is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00825 name: trans-4-coumarate biosynthesis namespace: pathway def: "Biosynthesis of 4-coumaric acid (trans-4-hydroxycinnamic acid), a phenylpropanoid compound." [UPa:amorgat] synonym: "4-hydroxycinnamic acid biosynthesis" EXACT [] synonym: "p-coumaric acid biosynthesis" EXACT [] synonym: "trans-4-hydroxycinnamic acid biosynthesis" EXACT [] xref: KEGG:map00360 "Phenylalanine metabolism" xref: KEGG:map00940 "Phenylpropanoid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00711 ! phenylpropanoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00710 ! phenylpropanoid metabolism [Term] id: UPa:UPA00826 name: spermine metabolism namespace: pathway def: "Metabolism of spermine by the addition of a propylamine moiety to spermidine." [UPa:amorgat] synonym: "N,N'-bis(3-aminopropyl)-1,4-butanediamine metabolism" EXACT [] xref: GO:0008215 "biological_process:spermine metabolic process" is_a: UPa:UPA00455 ! amine and polyamine metabolism relationship: uniprot_super_pathway UPa:UPA00455 ! amine and polyamine metabolism [Term] id: UPa:UPA00827 name: poly(glycerol phosphate) teichoic acid biosynthesis namespace: pathway def: "Biosynthesis of poly(glycerol phosphate) teichoic acid." [UPa:amorgat] synonym: "poly(glycerol phosphate) TA biosynthesis" EXACT [] xref: GO:1902014 {source="rdfmatch"} is_a: UPa:UPA00632 ! teichoic acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00547 ! cell wall biogenesis [Term] id: UPa:UPA00828 name: poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis namespace: pathway def: "Biosynthesis of poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid." [UPa:amorgat] synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) TA biosynthesis" EXACT [] is_a: UPa:UPA00632 ! teichoic acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00547 ! cell wall biogenesis [Term] id: UPa:UPA00829 name: quinol/quinone biosynthesis namespace: pathway def: "Biosynthesis of quinol/quinone cofactors, such as menaquinone (vitamin K2), ubiquinone (coenzyme Q) or phylloquinone (vitamin K1)." [UPa:amorgat] synonym: "quinone cofactor biosynthesis" EXACT [] xref: GO:1901663 "biological_process:quinone biosynthetic process" is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA01055 ! quinol/quinone metabolism [Term] id: UPa:UPA00830 name: nicotinate biosynthesis namespace: pathway def: "Biosynthesis of nicotinic acid, also known as niacin or vitamin B3, a water-soluble vitamin." [UPa:amorgat] synonym: "niacin biosynthesis" EXACT [] synonym: "nicotinic acid biosynthesis" EXACT [] synonym: "vitamin B3 biosynthesis" EXACT [] xref: KEGG:map00760 "Nicotinate and nicotinamide metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA01009 ! nicotinate metabolism relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00831 name: protein ubiquitination (ubiquitin activation) namespace: pathway def: "The first step of the ubiquitination process. Ubiquitin is activated in a two-step reaction by an E1 ubiquitin-activating enzyme in a process requiring ATP as an energy source. The initial step involves production of a ubiquitin-adenylate intermediate. The second step transfers ubiquitin to the E1 active site cysteine residue, with release of AMP. This step results in a thioester linkage between the C-terminal carboxyl group of ubiquitin and the E1 cysteine sulfhydryl group. 2. Transfer of ubiquitin from E1 to the active site cysteine of a ubiquitin-conjugating enzyme E2 via a trans(thio)esterification reaction. 3. The final step of the ubiquitinylation cascade generally requires the activity of one of the hundreds of E3 ubiquitin-protein ligases (often termed simply ubiquitin ligase). E3 enzymes function as the substrate recognition modules of the system and are capable of interaction with both E2 and substrate. E3 enzymes possess one of two domains: * The HECT (Homologous to the E6-AP Carboxyl Terminus) domain * The RING domain (or the closely related U-box domain)." [UPa:amorgat] is_a: UPa:UPA00143 ! protein ubiquitination [Term] id: UPa:UPA00832 name: protein ubiquitination (E2 ubiquitin transfer) namespace: pathway def: "The second step of the ubiquitination process: transfer of ubiquitin from E1 to the active site cysteine of a ubiquitin-conjugating enzyme E2 via a trans(thio)esterification reaction." [UPa:amorgat] is_a: UPa:UPA00143 ! protein ubiquitination [Term] id: UPa:UPA00833 name: protein ubiquitination (ubiquitin transfer) namespace: pathway def: "The final step of the ubiquitinylation cascade generally requires the activity of one of the hundreds of E3 ubiquitin-protein ligases (often termed simply ubiquitin ligase). E3 enzymes function as the substrate recognition modules of the system and are capable of interaction with both E2 and substrate. E3 enzymes possess one of two domains: * The HECT (Homologous to the E6-AP Carboxyl Terminus) domain * The RING domain (or the closely related U-box domain)." [UPa:amorgat] is_a: UPa:UPA00143 ! protein ubiquitination [Term] id: UPa:UPA00834 name: heme O biosynthesis namespace: pathway def: "Biosynthesis of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. Heme O is a precursor in heme A biosyntesis. Warning: the biochemical reactions composing this pathway are not yet clearly defined." [UPa:amorgat] xref: GO:0048034 "biological_process:heme O biosynthetic process" xref: KEGG:map00860 "Porphyrin and chlorophyll metabolism" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:1336371 xref: PMID:8082800 is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00678 ! porphyrin-containing compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00677 ! porphyrin-containing compound metabolism [Term] id: UPa:UPA00835 name: 3-(3-hydroxyphenyl)propanoate degradation namespace: pathway def: "Degradation of 3-(3-hydroxyphenyl)propionic acid (3-HPP) into 3-(2,3-dihydroxyphenyl)propionic acid. 3-(2,3-dihydroxyphenyl)propionic acid is ultimately degraded to KREBS cycle intermediates. This pathway is common to 3-phenylpropionic acid degradation pathway, so it is recorded in a separate pathway." [UPa:amorgat] synonym: "3-HPP degradation" EXACT [] synonym: "3-hydroxyphenylpropionate degradation" EXACT [] synonym: "3-hydroxyphenylpropionic acid degradation" EXACT [] xref: GO:1901794 {source="rdfmatch"} is_a: UPa:UPA00712 ! phenylpropanoid degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00836 name: 3-(2,3-dihydroxyphenyl)propanoate degradation namespace: pathway def: "Degradation of 3-(2,3-dihydroxyphenyl)propionic acid to KREBS cycle intermediates." [UPa:amorgat] synonym: "2,3-dihydroxyphenylpropanoate degradation" EXACT [] synonym: "2,3-dihydroxyphenylpropionate degradation" EXACT [] synonym: "2,3-dihydroxyphenylpropionic acid degradation" EXACT [] xref: GO:1901791 {source="rdfmatch"} is_a: UPa:UPA00712 ! phenylpropanoid degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00837 name: melatonin biosynthesis namespace: pathway def: "Biosynthesis of melatonin (5-methoxy-N-acetyltryptamine), a naturally occurring hormone found in most animals and some of other living organisms, including algae." [UPa:amorgat] synonym: "5-methoxy-N-acetyltryptamine" EXACT [] xref: GO:0030187 "biological_process:melatonin biosynthetic process" xref: KEGG:map00380 "Tryptophan metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00435 ! hormone biosynthesis is_a: UPa:UPA00754 ! aromatic compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00838 name: amoeba cellulose biosynthesis namespace: pathway def: "Biosynthesis of amoeba cellulose." [UPa:amorgat] is_a: UPa:UPA00693 ! cellulose biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00839 name: tartrate degradation namespace: pathway def: "Degradation of tartrate, an aldaric acid that occurs naturally in many plants, particularly grapes, bananas, and tamarinds, and is one of the main acids found in wine." [UPa:amorgat] synonym: "2,3-dihydroxybutanedioic acid degradation" EXACT [] synonym: "tartaric acid degradation" EXACT [] synonym: "tartrate utilization" EXACT [] xref: KEGG:map00630 "Glyoxylate and dicarboxylate metabolism" xref: PMID:10339827 xref: PMID:7592429 is_a: UPa:UPA00794 ! aldaric acid degradation relationship: uniprot_super_pathway UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA00840 name: thiamine metabolism namespace: pathway def: "Metabolism of thiamin (vitamin B1), a water soluble vitamin." [UPa:amorgat] synonym: "vitamin B1 metabolism" EXACT [] xref: GO:0006772 "biological_process:thiamine metabolic process" is_a: UPa:UPA00398 ! cofactor metabolism [Term] id: UPa:UPA00841 name: thiamine degradation namespace: pathway def: "Degradation of thiamin (vitamin B1), a water soluble vitamin." [UPa:amorgat] synonym: "vitamin B1 degradation" EXACT [] xref: GO:0009230 "biological_process:thiamine catabolic process" xref: KEGG:map00730 "Thiamine metabolism" is_a: UPa:UPA00840 ! thiamine metabolism relationship: uniprot_super_pathway UPa:UPA00398 ! cofactor metabolism [Term] id: UPa:UPA00842 name: taxol biosynthesis namespace: pathway def: "Biosynthesis of the diterpenoid taxol (generic name paclitaxel). Paclitaxel is a highly effective anticancer drug used widely in the treatment of various carcinomas, melanomas, and sarcomas. This structurally complex taxane diterpenoid (taxoid) was first isolated from the bark of the Pacific yew (Taxus brevifolia Nutt.)." [UPa:amorgat] synonym: "paclitaxel biosynthesis" EXACT [] xref: GO:0042617 "biological_process:paclitaxel biosynthetic process" xref: KEGG:map00904 "Diterpenoid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:11524108 is_a: UPa:UPA00446 ! alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00843 name: zeaxanthin biosynthesis namespace: pathway def: "Biosynthesis of zeaxanthin, one of the most common carotenoid alcohols found in nature. It is the pigment that gives corn, saffron, and many other plants their characteristic color." [UPa:amorgat] xref: GO:1901827 {source="rdfmatch"} is_a: UPa:UPA00419 ! xantophyll biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA00844 name: teichuronic acid biosynthesis namespace: pathway def: "Biosynthesis of teichuronic acid, a phosphate-free carbohydrate polymer containing glucuronic acid." [UPa:amorgat] xref: GO:0050845 "biological_process:teichuronic acid biosynthetic process" xref: PMID:10627039 xref: PMID:12473097 is_a: UPa:UPA00320 ! biopolymer biosynthesis is_a: UPa:UPA00547 ! cell wall biogenesis is_a: UPa:UPA00613 ! polyol metabolism is_a: UPa:UPA00700 ! organic acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00547 ! cell wall biogenesis [Term] id: UPa:UPA00845 name: pectin biosynthesis namespace: pathway def: "Biosynthesis of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [UPa:amorgat] synonym: "poly(1,4-alpha-D-galacturonide) biosynthesis" EXACT [] xref: GO:0045489 "biological_process:pectin biosynthetic process" is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00846 name: serotonin biosynthesis namespace: pathway def: "Biosynthesis of serotonin (5-hydroxytryptamine, or 5-HT), a monoamine neurotransmitter. Serotonin is synthesized in serotonergic neurons in the central nervous system (CNS) and enterochromaffin cells in the gastrointestinal tract of animals including humans. Serotonin is also found in many mushrooms and plants, including fruits and vegetables. In plants, serotonin is implicated in several physiological roles such as flowering, morphogenesis, and adaptation to environmental changes." [UPa:amorgat] synonym: "5-HT biosynthesis" EXACT [] synonym: "5-hydroxytryptamine biosynthesis" EXACT [] xref: GO:0042427 "biological_process:serotonin biosynthetic process" xref: KEGG:map00380 "Tryptophan metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00526 ! L-tryptophan degradation is_a: UPa:UPA00754 ! aromatic compound biosynthesis relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00847 name: pteridine biosynthesis namespace: pathway def: "Biosynthesis of pteridine derivative compounds, a group of heterocyclic compounds composed of fused pyrimidine and pyrazine rings. Pterins and flavins are classes of substituted pteridines that have important biological activity." [UPa:amorgat] synonym: "pyrazino(2,3-dipyrimidine) biosynthesis" EXACT [] xref: GO:0006728 "biological_process:pteridine biosynthetic process" is_a: UPa:UPA00754 ! aromatic compound biosynthesis [Term] id: UPa:UPA00848 name: 7,8-dihydroneopterin triphosphate biosynthesis namespace: pathway def: "Biosynthesis of dihydroneopterin triphosphate, the first committed intermediate in the biosynthetic pathways of tetrahydrofolate in plants and microorganisms and of tetrahydrobiopterin in animals." [UPa:amorgat] synonym: "6-d-threo-1',2',3'-hydroxypropyl-7,8-dihydroneopterin 3'-triphosphate biosynthesis" EXACT [] synonym: "NH2TP biosynthesis" EXACT [] xref: GO:0035998 "biological_process:7,8-dihydroneopterin 3'-triphosphate biosynthetic process" xref: KEGG:map00790 "Folate biosynthesis" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00847 ! pteridine biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00849 name: tetrahydrobiopterin biosynthesis namespace: pathway def: "Biosynthesis of tetrahydrobiopterin (sapropterin, BH4, H4-biopterin). Tetrahydrobiopterin is an essential cofactor of a set of enzymes that are of central metabolic importance, i.e. the hydroxylases of the three aromatic amino acids phenylalanine, tyrosine, and tryptophan, of ether lipid oxidase, and of the three nitric oxide synthase (NOS) isoenzymes. Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylases; phenylalanine-4-hydroxylase, tyrosine-3-hydroxylase and tryptophan-5-hydroxylase. Tetrahydrobiopterin is also essential for the synthesis of nitric oxide by nitric oxide synthase (NOS)." [UPa:amorgat] synonym: "5,6,7,8-tetrahydrobiopterin biosynthesis" EXACT [] synonym: "BH4 biosynthesis" EXACT [] synonym: "H4-biopterin biosynthesis" EXACT [] synonym: "sapropterin biosynthesis" EXACT [] xref: GO:0006729 "biological_process:tetrahydrobiopterin biosynthetic process" xref: KEGG:map00790 "Folate biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: PMID:17220358 is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00847 ! pteridine biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00850 name: tetrahydrofolylpolyglutamate biosynthesis namespace: pathway def: "Biosynthesis of tetrahydrofolylpolyglutamates, a group of folate derivative compounds comprising tetrahydrofolate attached to a chain of glutamate residues. In organisms that require exogenous folates for growth (Lactobacillus casei, Streptococcus faecalis, mammals), highly anionic polyglutamate chain of folate (four glutamate residues or more) retard transport through the cell membrane. This is the mechanism thought to be responsible for the accumulation and maintenance of cellular folate pools. cell membrane." [UPa:amorgat] xref: GO:0046901 "biological_process:tetrahydrofolylpolyglutamate biosynthetic process" xref: PMID:18232714 xref: PMID:2688305 is_a: UPa:UPA00399 ! cofactor biosynthesis is_a: UPa:UPA00700 ! organic acid biosynthesis is_a: UPa:UPA00847 ! pteridine biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00851 name: mitomycin C biosynthesis namespace: pathway def: "Biosynthesis of mitomycin C, the first recognized bioreductive alkylating agent, widely used clinically for antitumor therapy. Mitomycinan are aziridine-containing natural products isolated from Streptomyces lavendulae." [UPa:amorgat] xref: GO:1901777 {source="rdfmatch"} xref: PMID:10094699 xref: PMID:10099135 is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00852 name: morphine biosynthesis namespace: pathway def: "Biosynthesis of morphine, an isoquinolin alkaloid." [UPa:amorgat] xref: PMID:2012614 is_a: UPa:UPA00510 ! isoquinoline alkaloid biosynthesis relationship: uniprot_super_pathway UPa:UPA00446 ! alkaloid biosynthesis [Term] id: UPa:UPA00853 name: nisin biosynthesis namespace: pathway def: "Biosynthesis of nisin, a 34-residue antibacterial peptide (lantibiotic family). Nisin is produced by several strains of Lactococcus lactis and strongly inhibits the growth of a broad range of gram-positive bacteria." [UPa:amorgat] xref: PMID:7689965 xref: PMID:8478324 is_a: UPa:UPA00470 ! lantibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00854 name: nonprotein amino-acid degradation namespace: pathway def: "Degradation of any amino-acid that does not normally occur as a constituent residue of proteins [source: GO]." [UPa:amorgat] is_a: UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00855 name: nopaline degradation namespace: pathway def: "Degradation of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [UPa:amorgat] xref: GO:0019468 {source="rdfmatch"} xref: PMID:7689965 xref: PMID:8478324 is_a: UPa:UPA00854 ! nonprotein amino-acid degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00856 name: 2-dehydro-3-deoxy-D-gluconate degradation namespace: pathway def: "Degradation of 2-dehydro-3-deoxy-D-gluconate, a product of pectin or galacturonate degradation." [UPa:amorgat] xref: KEGG:map00030 "Pentose phosphate pathway" xref: KEGG:map00040 "Pentose and glucuronate interconversions" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00791 ! aldonic acid degradation relationship: uniprot_super_pathway UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA00857 name: carbohydrate acid metabolism namespace: pathway def: "Metabolism of carbohydrate acid compounds." [UPa:amorgat] is_a: UPa:UPA00411 ! carbohydrate metabolism is_a: UPa:UPA00698 ! organic acid metabolism [Term] id: UPa:UPA00858 name: carbohydrate acid degradation namespace: pathway def: "Degradation of carbohydrate acid compounds." [UPa:amorgat] is_a: UPa:UPA00413 ! carbohydrate degradation is_a: UPa:UPA00699 ! organic acid degradation is_a: UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA00859 name: carbohydrate acid biosynthesis namespace: pathway def: "Biosynthesis of carbohydrate acid compounds." [UPa:amorgat] is_a: UPa:UPA00412 ! carbohydrate biosynthesis is_a: UPa:UPA00700 ! organic acid biosynthesis is_a: UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA00860 name: glycosaminoglycan metabolism namespace: pathway def: "Metabolism of glycosaminoglycan compounds, any one of a group of polysaccharides that contain amino sugars." [UPa:amorgat] xref: GO:0030203 "biological_process:glycosaminoglycan metabolic process" is_a: UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00861 name: glycosaminoglycan biosynthesis namespace: pathway def: "Biosynthesis of glycosaminoglycan compounds, any one of a group of polysaccharides that contain amino sugars." [UPa:amorgat] xref: GO:0006024 "biological_process:glycosaminoglycan biosynthetic process" is_a: UPa:UPA00860 ! glycosaminoglycan metabolism [Term] id: UPa:UPA00862 name: heparin biosynthesis namespace: pathway def: "Biosynthesis of heparin." [UPa:amorgat] xref: GO:0030210 "biological_process:heparin biosynthetic process" xref: PMID:11274177 is_a: UPa:UPA00861 ! glycosaminoglycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00863 name: butanoate metabolism namespace: pathway def: "Metabolism of butanoate (butyrate), a 4-carbon saturated monocarboxylic acid. This fatty acid occurs in the form of esters in animal fats and plant oils." [UPa:amorgat] synonym: "butyrate metabolism" EXACT [] xref: GO:0019605 "biological_process:butyrate metabolic process" is_a: UPa:UPA00199 ! fatty acid metabolism is_a: UPa:UPA00698 ! organic acid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00864 name: glycolate degradation namespace: pathway def: "Degradation of glycolic acid into 3-phospho-D-glyceric acid (an aldonic acid)." [UPa:amorgat] synonym: "hydroxyacetic acid degradation" EXACT [] synonym: "hydroxyethanoic acid degradation" EXACT [] xref: GO:0046296 "biological_process:glycolate catabolic process" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00561 "Glycerolipid metabolism" xref: KEGG:map00630 "Glyoxylate and dicarboxylate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00699 ! organic acid degradation is_a: UPa:UPA00857 ! carbohydrate acid metabolism relationship: uniprot_super_pathway UPa:UPA00698 ! organic acid metabolism [Term] id: UPa:UPA00865 name: glycolate biosynthesis namespace: pathway def: "Biosynthesis of glycolic acid (hydroxyacetic acid, hydroxyethanoic acid)." [UPa:amorgat] synonym: "hydroxyacetic acid biosynthesis" EXACT [] synonym: "hydroxyethanoic acid biosynthesis" EXACT [] xref: GO:0046295 "biological_process:glycolate biosynthetic process" xref: KEGG:map00630 "Glyoxylate and dicarboxylate metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00700 ! organic acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00698 ! organic acid metabolism [Term] id: UPa:UPA00866 name: Ehrlich pathway namespace: pathway def: "Catabolism of branched-chain amino acids (leucine, valine, and isoleucine), aromatic amino acids (phenylalanine, tyrosine, and trytophan), and the sulfur-containing amino acid (methionine) leads to the formation of fusel acids and fusel alcohols." [UPa:amorgat] xref: GO:0000955 "biological_process:amino acid catabolic process via Ehrlich pathway" xref: PMID:18281432 is_a: UPa:UPA00427 ! amino-acid degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00867 name: L-lysine degradation namespace: pathway def: "Degradation of L-lysine amino-acid." [UPa:amorgat] xref: GO:0019477 "biological_process:L-lysine catabolic process" xref: MetaCyc:PWY-5327 is_a: UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00868 name: L-lysine degradation via saccharopine pathway namespace: pathway def: "The mitochondrial pathway of L-lysine degradation via saccharopine is the major mammalian pathway for lysine degradation." [UPa:amorgat] xref: GO:0033512 "biological_process:L-lysine catabolic process to acetyl-CoA via saccharopine" xref: KEGG:map00300 "Lysine biosynthesis" xref: KEGG:map00310 "Lysine degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: MetaCyc:LYSINE-DEG1-PWY is_a: UPa:UPA00867 ! L-lysine degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00869 name: L-lysine degradation via acetylation pathway namespace: pathway def: "Degradation of L-lysine via acetylation pathway. In this fungal pathway, L-lysine is degraded to glutarate via acetylation of the 6-amino group to the initial product N6-acetyl-L-lysine. This is followed by transamination, oxidative decarboxylation, deacetylation, transamination with loss of the second amino group, and oxidation to glutarate." [UPa:amorgat] xref: GO:0019473 "biological_process:L-lysine catabolic process to glutarate, by acetylation" xref: KEGG:map00310 "Lysine degradation" xref: MetaCyc:LYSDEGII-PWY xref: PMID:15229592 xref: PMID:8082161 is_a: UPa:UPA00867 ! L-lysine degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00870 name: L-lysine degradation via acetate pathway namespace: pathway def: "UPC00047 fermentation process into acetate, butanoate and ammonia." [UPa:amorgat] synonym: "UPC00047 fermentation" EXACT [] xref: GO:0019475 "biological_process:L-lysine catabolic process to acetate" xref: PMID:10629195 xref: PMID:10839984 xref: PMID:17166837 is_a: UPa:UPA00867 ! L-lysine degradation relationship: uniprot_super_pathway UPa:UPA00427 ! amino-acid degradation [Term] id: UPa:UPA00871 name: benzoxazinone biosynthesis namespace: pathway def: "Biosynthesis of benzoxazinone compounds. These cyclic hydroxamic acids are dedicated to pathogen defense and are found almost exclusively in Gramineae." [UPa:amorgat] xref: PMID:9235894 is_a: UPa:UPA00464 ! secondary metabolite biosynthesis is_a: UPa:UPA00754 ! aromatic compound biosynthesis [Term] id: UPa:UPA00872 name: 2,4-dihydroxy-1,4-benzoxazin-3-one biosynthesis namespace: pathway def: "Biosynthesis of 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA), a cyclic hydroxamic acid. This secondary metabolites found predominantly in Gramineae such as many maize (Zea mays)." [UPa:amorgat] synonym: "DIBOA biosynthesis" EXACT [] xref: KEGG:map00400 "Phenylalanine, tyrosine and tryptophan biosynthesis" xref: KEGG:map00402 "Benzoxazinoid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: MetaCyc:PWY-4161 xref: PMID:9235894 is_a: UPa:UPA00871 ! benzoxazinone biosynthesis relationship: uniprot_super_pathway UPa:UPA00464 ! secondary metabolite biosynthesis [Term] id: UPa:UPA00873 name: (R)-mandelate degradation namespace: pathway def: "Degradation of mandelic acid. This pathway provides the means to allow a variety of pseudomonads, including Pseudomonas putida, to use one or both enantiomers of mandelic acid as the sole carbon source." [UPa:amorgat] synonym: "alpha-hydroxybenzeneacetic acid degradation" EXACT [] synonym: "mandelic acid degradation" EXACT [] xref: GO:0019596 "biological_process:mandelate catabolic process" xref: KEGG:map00627 "Aminobenzoate degradation" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:PWY-1501 xref: PMID:12670968 xref: PMID:2271624 is_a: UPa:UPA00699 ! organic acid degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00874 name: HC-toxin biosynthesis namespace: pathway def: "Biosynthesis of HC-toxin, a cyclic tetrapeptide of structure cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino-9,10-epoxi-8-oxodecanoic acid HC-toxin is an essential virulence determinant for the plant pathogenic fungus Cochliobolus carbonum and an inhibitor of histone deacetylase." [UPa:amorgat] xref: PMID:16839576 is_a: UPa:UPA00478 ! mycotoxin biosynthesis relationship: uniprot_super_pathway UPa:UPA00478 ! mycotoxin biosynthesis [Term] id: UPa:UPA00875 name: lovastatin biosynthesis namespace: pathway def: "Biosynthesis of lovastatin, an HMG-CoA reductase inhibitor produced by the fungus Aspergillus terreus. Lovastatin is composed of two polyketide chains." [UPa:amorgat] xref: PMID:10381407 is_a: UPa:UPA00473 ! polyketide biosynthesis relationship: uniprot_super_pathway UPa:UPA00473 ! polyketide biosynthesis [Term] id: UPa:UPA00876 name: leukotriene biosynthesis namespace: pathway def: "Biosynthesis of leukotrienes, eicosanoid lipid mediators derived from arachidonic acid." [UPa:amorgat] xref: GO:0019370 "biological_process:leukotriene biosynthetic process" is_a: UPa:UPA00884 ! leukotriene metabolism [Term] id: UPa:UPA00877 name: leukotriene A4 biosynthesis namespace: pathway def: "Biosynthesis of leukotriene A4 (LTA4)." [UPa:amorgat] synonym: "LTA4 biosynthesis" EXACT [] xref: GO:1901753 {source="rdfmatch"} is_a: UPa:UPA00876 ! leukotriene biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00878 name: leukotriene B4 biosynthesis namespace: pathway def: "Biosynthesis of leukotriene B4 (LTB4)." [UPa:amorgat] synonym: "LTB4 biosynthesis" EXACT [] xref: GO:0097251 {source="rdfmatch"} is_a: UPa:UPA00876 ! leukotriene biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00879 name: leukotriene C4 biosynthesis namespace: pathway def: "Biosynthesis of leukotriene C4 (LTC4)." [UPa:amorgat] synonym: "LTC4 biosynthesis" EXACT [] is_a: UPa:UPA00876 ! leukotriene biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00880 name: leukotriene D4 biosynthesis namespace: pathway def: "Biosynthesis of leukotriene D4 (LTD4)." [UPa:amorgat] synonym: "LTD4 biosynthesis" EXACT [] xref: GO:1901750 {source="rdfmatch"} is_a: UPa:UPA00876 ! leukotriene biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00881 name: hydroperoxy eicosatetraenoic acid biosynthesis namespace: pathway def: "Biosynthesis of hydroperoxy (e)icosatetraenoic acids (HPETEs), the primary products of lipoxygenase-catalysed oxygenation of arachidonic acid." [UPa:amorgat] synonym: "HPETE biosynthesis" EXACT [] is_a: UPa:UPA00383 ! arachidonate metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00882 name: leukotriene degradation namespace: pathway def: "Degradation of leukotrienes, eicosanoid lipid mediators derived from arachidonic acid." [UPa:amorgat] xref: GO:0036100 {source="rdfmatch"} is_a: UPa:UPA00884 ! leukotriene metabolism [Term] id: UPa:UPA00883 name: leukotriene B4 degradation namespace: pathway def: "Degradation of leukotriene B4 (LTB4)." [UPa:amorgat] synonym: "LTB4 degradation" EXACT [] xref: GO:0036101 {source="rdfmatch"} is_a: UPa:UPA00882 ! leukotriene degradation relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00884 name: leukotriene metabolism namespace: pathway def: "Metabolism of leukotrienes, eicosanoid lipid mediators derived from arachidonic acid." [UPa:amorgat] xref: GO:0006691 "biological_process:leukotriene metabolic process" is_a: UPa:UPA00383 ! arachidonate metabolism [Term] id: UPa:UPA00885 name: protein neddylation namespace: pathway def: "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [UPa:amorgat] xref: GO:0045116 "biological_process:protein neddylation" xref: PMID:11698580 is_a: UPa:UPA00460 ! protein modification relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00886 name: protein sumoylation namespace: pathway def: "Covalent modification of cellular proteins by the ubiquitin-like modifier SUMO. Protein sumoylation regulates various cellular processes, such as nuclear transport, signal transduction, stress response and cell-cycle progression." [UPa:amorgat] xref: GO:0016925 "biological_process:protein sumoylation" xref: PMID:11265250 is_a: UPa:UPA00460 ! protein modification relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00887 name: auxin metabolism namespace: pathway def: "Metabolism of auxins (indole-3-acetic acid, IAA), natural plant hormones involved in several stages of plant growth and development such as cell elongation, cell division, tissue differentiation, and apical dominance." [UPa:amorgat] synonym: "IAA metabolism" EXACT [] synonym: "indole-3-acetate metabolism" EXACT [] synonym: "indole-3-acetic acid metabolism" EXACT [] xref: GO:0009850 "biological_process:auxin metabolic process" is_a: UPa:UPA00437 ! plant hormone metabolism [Term] id: UPa:UPA00888 name: limonene degradation namespace: pathway def: "Degradation of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. Limonene is the most widespread terpene in the world and is formed by more than 300 plants." [UPa:amorgat] synonym: "4-isopropenyl-1-methylcyclohexene degradation" EXACT [] synonym: "cajeputene degradation" EXACT [] synonym: "DL-limonene degradation" EXACT [] synonym: "kautschin degradation" EXACT [] xref: GO:0046251 "biological_process:limonene catabolic process" xref: PMID:10224006 is_a: UPa:UPA00137 ! monoterpene degradation relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00889 name: melamine degradation namespace: pathway def: "Degradation of melamine (1,3,5-triazine-2,4,6-triamine). Melamine is a metabolite of cyromazine, a pesticide. It is formed in the body of mammals who have ingested cyromazine. It was also reported that cyromazine is converted to melamine in plants." [UPa:amorgat] synonym: "1,3,5-triazine-2,4,6-triamine degradation" EXACT [] xref: PMID:7592318 is_a: UPa:UPA00105 ! xenobiotic degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00890 name: secondary metabolite degradation namespace: pathway def: "Degradation of secondary metabolites." [UPa:amorgat] xref: GO:0090487 {source="rdfmatch"} is_a: UPa:UPA00465 ! secondary metabolite metabolism [Term] id: UPa:UPA00891 name: lignin metabolism namespace: pathway def: "Metabolism of lignin, a class of polymers of phenylpropanoid units." [UPa:amorgat] xref: GO:0009808 "biological_process:lignin metabolic process" is_a: UPa:UPA00465 ! secondary metabolite metabolism is_a: UPa:UPA00710 ! phenylpropanoid metabolism [Term] id: UPa:UPA00892 name: lignin degradation namespace: pathway def: "Degradation of lignin, a class of polymers of phenylpropanoid units." [UPa:amorgat] xref: GO:0046274 "biological_process:lignin catabolic process" is_a: UPa:UPA00890 ! secondary metabolite degradation is_a: UPa:UPA00891 ! lignin metabolism relationship: uniprot_super_pathway UPa:UPA00465 ! secondary metabolite metabolism [Term] id: UPa:UPA00893 name: lignin biosynthesis namespace: pathway def: "Biosynthesis of lignin, a class of polymers of phenylpropanoid units." [UPa:amorgat] xref: GO:0009809 "biological_process:lignin biosynthetic process" is_a: UPa:UPA00464 ! secondary metabolite biosynthesis is_a: UPa:UPA00891 ! lignin metabolism [Term] id: UPa:UPA00894 name: diglucosyl-diacylglycerol biosynthesis namespace: pathway def: "Biosynthesis of diglucosyl-diacylglycerol, a component of membrane glycolipids." [UPa:amorgat] xref: GO:0009246 "biological_process:enterobacterial common antigen biosynthetic process" xref: PMID:10515954 xref: PMID:12618464 xref: PMID:16199561 xref: PMID:16936038 is_a: UPa:UPA00506 ! glycolipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00505 ! glycolipid metabolism [Term] id: UPa:UPA00895 name: methylamine degradation namespace: pathway def: "Degradation of methylamine into formaldehyde (methanal)." [UPa:amorgat] synonym: "formaldehyde biosynthesis" EXACT [] synonym: "methanal biosynthesis" EXACT [] xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00445 ! one-carbon metabolism relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00896 name: (S)-3-hydroxy-3-methylglutaryl-CoA degradation namespace: pathway def: "Degradation of HMG-CoA ((S)-3-hydroxy-3-methylglutaryl-CoA) into acetoacetic acid. HMG-CoA is an intermediate in the mevalonic acid and leucine degradation pathways." [UPa:amorgat] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA" EXACT [] synonym: "ketogenesis" EXACT [] synonym: "ketone biosynthesis" EXACT [] xref: KEGG:map00072 "Synthesis and degradation of ketone bodies" xref: KEGG:map00280 "Valine, leucine and isoleucine degradation" xref: KEGG:map00650 "Butanoate metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00498 ! metabolic intermediate degradation relationship: uniprot_super_pathway UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00897 name: isoflavonoid phytoalexin biosynthesis namespace: pathway def: "Biosynthesis of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection [source: GO]." [UPa:amorgat] xref: GO:0009701 "biological_process:isoflavonoid phytoalexin biosynthetic process" is_a: UPa:UPA00154 ! flavonoid biosynthesis is_a: UPa:UPA00421 ! phytoalexin biosynthesis [Term] id: UPa:UPA00898 name: glyceollin biosynthesis namespace: pathway def: "Biosynthesis of glyceollins. The glyceollins belong to the isoflavonoid phytoalexins." [UPa:amorgat] xref: PMID:1840523 is_a: UPa:UPA00897 ! isoflavonoid phytoalexin biosynthesis relationship: uniprot_super_pathway UPa:UPA00421 ! phytoalexin biosynthesis [Term] id: UPa:UPA00899 name: phenylpropanoid phytoalexin biosynthesis namespace: pathway def: "Biosynthesis of phenylpropanoid phytoalexins." [UPa:amorgat] is_a: UPa:UPA00421 ! phytoalexin biosynthesis is_a: UPa:UPA00711 ! phenylpropanoid biosynthesis [Term] id: UPa:UPA00900 name: methoxydianthramide B biosynthesis namespace: pathway def: "Biosynthesis of methoxydianthramide B (N-benzoyl-4-O-methoxyanthranilate), a phenylpropanoid phytoalexin." [UPa:amorgat] synonym: "N-benzoyl-4-O-methoxyanthranilate biosynthesis" EXACT [] xref: PMID:9869425 is_a: UPa:UPA00899 ! phenylpropanoid phytoalexin biosynthesis relationship: uniprot_super_pathway UPa:UPA00421 ! phytoalexin biosynthesis [Term] id: UPa:UPA00901 name: pterocarpan phytoalexin biosynthesis namespace: pathway def: "Biosynthesis of pterocarpan phytoalexins (medicarpin and maackian)." [UPa:amorgat] xref: PMID:1915347 is_a: UPa:UPA00897 ! isoflavonoid phytoalexin biosynthesis relationship: uniprot_super_pathway UPa:UPA00421 ! phytoalexin biosynthesis [Term] id: UPa:UPA00902 name: medicarpin biosynthesis namespace: pathway def: "Biosynthesis of medicarpin, the major phytoalexin in alfalfa. Medicarpin is synthesized via the isoflavonoid branch of phenylpropanoid metabolism." [UPa:amorgat] xref: PMID:1915347 xref: PMID:9484461 is_a: UPa:UPA00901 ! pterocarpan phytoalexin biosynthesis relationship: uniprot_super_pathway UPa:UPA00421 ! phytoalexin biosynthesis [Term] id: UPa:UPA00903 name: L-methionine biosynthesis namespace: pathway def: "Biosynthesis of sulfur-containing amino-acid L-methionine (2-amino-4-(methylthio)butanoic acid). L-methionine is an essential amino-acid for many crucial cellular functions, including the initiation of protein synthesis, methylation of DNA and rRNA, and biosynthesis of cysteine, phospholipids and polyamines." [UPa:amorgat] synonym: "2-amino-4-(methylthio)butanoic acid biosynthesis" EXACT [] xref: GO:0009086 "biological_process:methionine biosynthetic process" is_a: UPa:UPA00218 ! L-methionine metabolism is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis [Term] id: UPa:UPA00904 name: L-methionine biosynthesis via salvage pathway namespace: pathway def: "The methionine salvage pathway (MSP) is an important metabolic pathway in maintaining the amount of L-methionine as the amount of methionine in cells is typically limiting and its de novo biosynthesis is energetically expensive. Therefore, L-methionine is salvaged from S-methyl-5'-thioadenosine (MTA), the end-product of spermidine biosynthesis." [UPa:amorgat] synonym: "2-amino-4-(methylthio)butanoic acid salvage" EXACT [] synonym: "methionine salvage pathway (MSP)" EXACT [] xref: GO:0019509 "biological_process:L-methionine biosynthetic process from methylthioadenosine" xref: KEGG:map00270 "Cysteine and methionine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00903 ! L-methionine biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA00905 name: aminoacyl-tRNA biosynthesis namespace: pathway def: "Biosynthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase." [UPa:amorgat] synonym: "tRNA aminoacylation" EXACT [] synonym: "tRNA charching" EXACT [] xref: GO:0043039 "biological_process:tRNA aminoacylation" is_a: UPa:UPA00481 ! tRNA modification [Term] id: UPa:UPA00906 name: selenocysteinyl-tRNA(Sec) biosynthesis namespace: pathway def: "Biosynthesis of selenocysteinyl-tRNA(Sec). If the pathway for selenocysteine biosynthesis differs in bacteria from that present in eukaryotes and archaea; tRNA(Sec) remains a common factor for selenocysteine formation among the three kingdoms." [UPa:amorgat] xref: GO:0097056 "biological_process:selenocysteinyl-tRNA(Sec) biosynthetic process" xref: KEGG:map00450 "Selenocompound metabolism" xref: KEGG:map00970 "Aminoacyl-tRNA biosynthesis" is_a: UPa:UPA00905 ! aminoacyl-tRNA biosynthesis relationship: uniprot_super_pathway UPa:UPA00905 ! aminoacyl-tRNA biosynthesis [Term] id: UPa:UPA00907 name: 2-deoxystreptamine biosynthesis namespace: pathway def: "Biosynthesis of 2-deoxystreptamine (DOS)." [UPa:amorgat] synonym: "DOS biosynthesis" EXACT [] xref: KEGG:map00524 "Butirosin and neomycin biosynthesis" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:14757238 xref: PMID:14969406 xref: PMID:15313224 is_a: UPa:UPA00415 ! metabolic intermediate biosynthesis relationship: uniprot_super_pathway UPa:UPA00415 ! metabolic intermediate biosynthesis [Term] id: UPa:UPA00908 name: ppGpp biosynthesis namespace: pathway def: "Biosynthesis of ppGpp (guanosine tetraphosphate, guanosine 5'-diphosphate 3'-diphosphate), a derivative of guanine riboside. The stringent response to amino acid starvation, whereby stable RNA synthesis is curtailed in favour of transcription of amino acid biosynthetic genes, is controlled by the alarmone ppGpp." [UPa:amorgat] synonym: "5'-ppGpp-3' biosynthesis" EXACT [] synonym: "guanosine 5'-diphosphate 3'-diphosphate biosynthesis" EXACT [] synonym: "guanosine tetraphosphate biosynthesis" EXACT [] xref: GO:0015970 "biological_process:guanosine tetraphosphate biosynthetic process" xref: KEGG:map00230 "Purine metabolism" xref: MetaCyc:PPGPPMET-PWY is_a: UPa:UPA00488 ! purine nucleotide biosynthesis relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00909 name: GMP biosynthesis via salvage pathway namespace: pathway def: "GMP biosynthesis from guanine (salvage pathway)." [UPa:amorgat] synonym: "GMP salvage" EXACT [] synonym: "guanosine 5'-phosphate biosynthesis via salvage pathway" EXACT [] synonym: "guanosine monophosphate biosynthesis via salvage pathway" EXACT [] xref: GO:0032263 "biological_process:GMP salvage" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00424 ! nucleotide biosynthesis is_a: UPa:UPA00584 ! purine biosynthesis relationship: uniprot_super_pathway UPa:UPA00583 ! purine metabolism [Term] id: UPa:UPA00910 name: sulfatase oxidation namespace: pathway def: "Maturation of sulfatase through oxidation of a specific cysteine to Calpha-formylglycine (Fgly), a catalytic residue in their active site." [UPa:amorgat] xref: PMID:16368756 xref: PMID:9342345 is_a: UPa:UPA00460 ! protein modification relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00911 name: retinoid metabolism namespace: pathway def: "Metabolism of retinoids, a class of chemical compounds that are related chemically to vitamin A. Retinoids have many important and diverse functions throughout the body including roles in vision, regulation of cell proliferation and differentiation, growth of bone tissue, immune function, and activation of tumor suppressor genes." [UPa:amorgat] xref: GO:0001523 "biological_process:retinoid metabolic process" is_a: UPa:UPA00913 ! isoprenoid metabolism [Term] id: UPa:UPA00912 name: retinol metabolism namespace: pathway def: "Metabolism of retinol, the animal form of vitamin A. Retinol is a fat-soluble vitamin important in vision and bone growth. It belongs to the family of chemical compounds known as retinoids." [UPa:amorgat] synonym: "vitamin A metabolism" EXACT [] xref: GO:0042572 "biological_process:retinol metabolic process" is_a: UPa:UPA00398 ! cofactor metabolism is_a: UPa:UPA00913 ! isoprenoid metabolism relationship: uniprot_super_pathway UPa:UPA00398 ! cofactor metabolism [Term] id: UPa:UPA00913 name: isoprenoid metabolism namespace: pathway def: "Metabolism of isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [source: GO] Isoprene is the chemical 2-methyl-1,3-butadiene. It is a common structural motif in biological systems. The terpenes (for example, the carotenes are tetraterpenes) are derived from isoprene, as are the terpenoids and coenzyme Q. Also derived from isoprene are phytol, retinol (vitamin A) , tocopherol (vitamin E), dolichols, and squalene. Heme A has an isoprenoid tail, and lanosterol, the sterol precursor in animals, is derived from squalene and hence from isoprene. The functional isoprene units in biological systems are dimethylallyl pyrophosphate (DMAPP) and its isomer isopentenyl pyrophosphate (IPP), which are used in the biosynthesis of terpenes and lanosterol derivatives." [UPa:amorgat] xref: GO:0006720 "biological_process:isoprenoid metabolic process" is_a: UPa:UPA00436 ! lipid metabolism is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00914 name: myo-inositol metabolism namespace: pathway def: "Metabolism of myo-inositol (cis-1,2,3,5-trans-4,6-cyclohexanehexol), arbocyclic polyol that plays an important role as the structural basis for a number of secondary messengers in eukaryotic cells, including inositol phosphates, phosphatidylinositol (PI) and phosphatidylinositol phosphate (PIP) lipids." [UPa:amorgat] xref: GO:0006020 "biological_process:inositol metabolic process" is_a: UPa:UPA00613 ! polyol metabolism relationship: uniprot_super_pathway UPa:UPA00613 ! polyol metabolism [Term] id: UPa:UPA00915 name: mycolic acid biosynthesis namespace: pathway def: "Biosynthesis of mycolic acids. Mycolic acids are essential elements of the mycobacterial envelope." [UPa:amorgat] xref: GO:0071768 {source="rdfmatch"} xref: PMID:9044265 is_a: UPa:UPA00420 ! lipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00916 name: D-ribose degradation namespace: pathway def: "Degradation of D-ribose carbohydrate. D-ribose, which can serve as a total source of carbon and energy for E. coli, enters the cell via a high-affinity ABC transport system and hence in unphosphorylated form. The ribose ABC transporter facilitates transport of beta-D-ribopyranose. which is converted to furanose forms of beta-D-ribose. Interconversion of the alpha- and beta-anomers of D-ribofuranose is fast and spontaneous. It is then converted to D-ribose-5-phosphate, an intermediate of the pentose phosphate pathway." [UPa:amorgat] xref: GO:0019303 "biological_process:D-ribose catabolic process" xref: KEGG:map00030 "Pentose phosphate pathway" xref: MetaCyc:RIBOKIN-PWY xref: PMID:15060078 is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00917 name: poly-(R)-3-hydroxybutanoate biosynthesis namespace: pathway def: "Biosynthesis of poly-(R)-3-hydroxybutyric acid (PHB), a homopolymer of D-(-)-3-hydroxybutyrate that belongs to a family of naturally occurring, biodegradable polyesters, known as polyhydroxyalkanoates (PHA). PHB is a storage material produced by a variety of bacteria in response to environmental stress. PHA act as reserve compounds for carbon, energy, and reducing equivalents and are of interest because their material properties make them a potential alternative to some petroleum-based thermoplastics." [UPa:amorgat] synonym: "PHB biosynthesis" EXACT [] synonym: "polyhydroxybutyrate biosynthesis" EXACT [] xref: GO:0042619 {source="rdfmatch"} xref: MetaCyc:PWY1-3 xref: PMID:15691921 is_a: UPa:UPA00320 ! biopolymer biosynthesis relationship: uniprot_super_pathway UPa:UPA00316 ! biopolymer metabolism [Term] id: UPa:UPA00918 name: patulin biosynthesis namespace: pathway def: "Biosynthesis of patulin, a mycotoxin produced by 14 species of the genus Penicillium and is most likely to be found in fruits, silage and dung. Patulin is also an antibiotic." [UPa:amorgat] xref: PMID:2209605 is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00478 ! mycotoxin biosynthesis relationship: uniprot_super_pathway UPa:UPA00478 ! mycotoxin biosynthesis [Term] id: UPa:UPA00919 name: 2-oxosuberate biosynthesis namespace: pathway def: "Biosynthesis of 2-oxosuberate (alpha-ketosuberate), a precursor to coenzyme B (7-mercaptoheptanoylthreonine phosphate) and biotin." [UPa:amorgat] synonym: "alpha-ketosuberate biosynthesis" EXACT [] xref: PMID:10940051 xref: PMID:9665716 is_a: UPa:UPA00415 ! metabolic intermediate biosynthesis is_a: UPa:UPA00700 ! organic acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00698 ! organic acid metabolism [Term] id: UPa:UPA00920 name: pyruvate fermentation namespace: pathway def: "Conversion of pyruvate (the final product of glycolysis) to formic acid in the absence of oxygen." [UPa:amorgat] xref: KEGG:map00620 "Pyruvate metabolism" xref: KEGG:map00650 "Butanoate metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00231 ! pyruvate metabolism is_a: UPa:UPA00498 ! metabolic intermediate degradation is_a: UPa:UPA00553 ! fermentation is_a: UPa:UPA00699 ! organic acid degradation relationship: uniprot_super_pathway UPa:UPA00553 ! fermentation [Term] id: UPa:UPA00921 name: mRNA processing namespace: pathway def: "Conversion of a primary mRNA transcript into one or more functional mRNA(s). This includes 5' capping, 3' cleavage and polyadenylation, as well as mRNA splicing and RNA editing." [UPa:amorgat] synonym: "messenger RNA processing" EXACT [] xref: GO:0006397 "biological_process:mRNA processing" is_a: UPa:UPA00480 ! RNA modification [Term] id: UPa:UPA00922 name: mRNA capping namespace: pathway def: "The 5' ends of most eukaryotic mRNAs and many viral mRNAs harbor a m7GpppN cap structure that plays a critical role in the translation and stability of mRNAs. Biosynthesis of this cap structure involves three distinct enzymatic activities: (i) the 5' end of pre-mRNAs is initially hydrolyzed to a diphosphate end by an RNA triphosphatase; (ii) the diphosphate end of the mRNA is then capped with GMP by an RNA guanylyltransferase, and finally, (iii) the cap is methylated by an RNA (guanine-7) methyltransferase. Addition of the 7-methylguanosine cap to the 5' end of a eukaryotic mRNA transcript." [UPa:amorgat] synonym: "messenger RNA capping" EXACT [] xref: GO:0006370 "biological_process:7-methylguanosine mRNA capping" xref: PMID:11051760 xref: PMID:18298088 is_a: UPa:UPA00921 ! mRNA processing relationship: uniprot_super_pathway UPa:UPA00921 ! mRNA processing [Term] id: UPa:UPA00923 name: nitrobenzene degradation namespace: pathway def: "Degradation of nitrobenzene. Pseudomonas pseudoalcaligenes JS45 utilizes nitrobenzene as the sole source of nitrogen, carbon, and energy. Some studies have shown that degradation of nitrobenzene involves the reduction of nitrobenzene to nitrosobenzene and hydroxylaminobenzene, followed by rearrangement to 2-aminophenol, which then undergoes meta ring cleavage to 2-aminomuconic semialdehyde. Comamonas sp. JS765 can also use nitrobenzene as the sole source of carbon, nitrogen, and energy. It inserts dioxygen directly into nitrobenzene, with concomitant reduction of the substrate to form catechol." [UPa:amorgat] xref: GO:1900998 {source="rdfmatch"} xref: PMID:9471964 xref: PMID:9573204 is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA00924 name: oleoresin biosynthesis namespace: pathway def: "Biosynthesis of oleoresin, a complex mixture of mono-, sesqui-, and diterpenoids that accumulates at the wound site to kill invaders and both flush and seal the injury." [UPa:amorgat] xref: PMID:11337413 is_a: UPa:UPA00448 ! terpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00925 name: stachyose biosynthesis namespace: pathway def: "Biosynthesis of stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [UPa:amorgat] xref: GO:0033532 "biological_process:stachyose biosynthetic process" xref: KEGG:map00052 "Galactose metabolism" xref: PMID:11675396 is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00926 name: oxytetracycline biosynthesis namespace: pathway def: "Biosynthesis of oxytetracycline, an acetate-derived polyketide antibiotic that belongs to the broad-spectrum tetracycline group." [UPa:amorgat] xref: GO:1901763 {source="rdfmatch"} xref: PMID:8163168 is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00473 ! polyketide biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00927 name: formaldehyde assimilation via serine pathway namespace: pathway def: "The serine cycle for formaldehyde assimilation (QSC) is the main assimilatory pathway for methylotrophic growth." [UPa:amorgat] synonym: "serine cycle" EXACT [] synonym: "serine pathway" EXACT [] xref: MetaCyc:PWY-1622 xref: PMID:16237034 xref: PMID:8509332 is_a: UPa:UPA00445 ! one-carbon metabolism relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00928 name: methanol degradation namespace: pathway def: "Conversion of methanol into forrmaldehyde." [UPa:amorgat] synonym: "formaldehyde biosynthesis" EXACT [] xref: GO:0046170 "biological_process:methanol catabolic process" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:1644761 is_a: UPa:UPA00445 ! one-carbon metabolism relationship: uniprot_super_pathway UPa:UPA00445 ! one-carbon metabolism [Term] id: UPa:UPA00929 name: succinyl-CoA degradation namespace: pathway def: "Degradation of succinyl-CoA into acetoacetyl-CoA." [UPa:amorgat] xref: KEGG:map00072 "Synthesis and degradation of ketone bodies" xref: KEGG:map00280 "Valine, leucine and isoleucine degradation" xref: KEGG:map00650 "Butanoate metabolism" xref: PMID:12463743 is_a: UPa:UPA00410 ! ketone degradation relationship: uniprot_super_pathway UPa:UPA00408 ! ketone metabolism [Term] id: UPa:UPA00930 name: phenylacetate degradation namespace: pathway def: "Degradation of phenylacetic acid (PAA, benzeneacetic acid), an organic compound containing a phenyl functional group and an acetic acid functional group. Phenylacetic acid is a common source of carbon and energy for a wide variety of microorganisms." [UPa:amorgat] synonym: "benzeneacetic acid degradation" EXACT [] synonym: "PA degradation" EXACT [] synonym: "PAA degradation" EXACT [] xref: GO:0010124 "biological_process:phenylacetate catabolic process" xref: PMID:17259607 xref: PMID:9748275 is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00931 name: cellular component biogenesis namespace: pathway def: "Biogenesis of cellular components." [UPa:amorgat] xref: GO:0016043 "biological_process:cellular component organization" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00932 name: cell surface structure biogenesis namespace: pathway def: "Biogenesis of extracellular cell structures: fimbrae, pili, S-layers, capsules and slime layers." [UPa:amorgat] synonym: "extracellular cell structure biogenesis" EXACT [] is_a: UPa:UPA00931 ! cellular component biogenesis [Term] id: UPa:UPA00933 name: capsule biogenesis namespace: pathway def: "Formation, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi." [UPa:amorgat] xref: GO:0045230 "biological_process:capsule organization" is_a: UPa:UPA00932 ! cell surface structure biogenesis [Term] id: UPa:UPA00934 name: capsule polysaccharide biosynthesis namespace: pathway def: "Biosynthesis of polysaccharides that make up the capsule, a mucopolysaccharide protective structure surrounding some species of bacteria and fungi." [UPa:amorgat] synonym: "capsular polysaccharide biosynthesis" EXACT [] synonym: "CPS biosynthesis" EXACT [] xref: GO:0045227 "biological_process:capsule polysaccharide biosynthetic process" is_a: UPa:UPA00484 ! glycan biosynthesis is_a: UPa:UPA00933 ! capsule biogenesis relationship: uniprot_super_pathway UPa:UPA00933 ! capsule biogenesis [Term] id: UPa:UPA00935 name: slime biogenesis namespace: pathway def: "Biosynthesis of slime layer envelopping the cell." [UPa:amorgat] xref: GO:0045231 "biological_process:slime layer organization" is_a: UPa:UPA00932 ! cell surface structure biogenesis [Term] id: UPa:UPA00936 name: slime polysaccharide biosynthesis namespace: pathway def: "Biosynthesis of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall." [UPa:amorgat] xref: GO:0045228 "biological_process:slime layer polysaccharide biosynthetic process" is_a: UPa:UPA00935 ! slime biogenesis relationship: uniprot_super_pathway UPa:UPA00935 ! slime biogenesis [Term] id: UPa:UPA00937 name: p-cumate degradation namespace: pathway def: "Degradation of p-cumic acid, an aromatic hydrocarbon compound." [UPa:amorgat] synonym: "p-cumic acid degradation" EXACT [] synonym: "p-isopropylbenzoic acid degradation" EXACT [] xref: KEGG:map00360 "Phenylalanine metabolism" xref: KEGG:map00362 "Benzoate degradation" xref: KEGG:map00621 "Dioxin degradation" xref: KEGG:map00622 "Xylene degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:8631713 is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA00938 name: membrane lipid biosynthesis namespace: pathway def: "Biosynthesis of membrane lipids, any lipid found in or associated with a biological membrane." [UPa:amorgat] xref: GO:0046467 "biological_process:membrane lipid biosynthetic process" is_a: UPa:UPA00420 ! lipid biosynthesis is_a: UPa:UPA00939 ! membrane lipid metabolism [Term] id: UPa:UPA00939 name: membrane lipid metabolism namespace: pathway def: "Metabolism of membrane lipids, any lipid found in or associated with a biological membrane." [UPa:amorgat] xref: GO:0006643 "biological_process:membrane lipid metabolic process" is_a: UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA00940 name: glycerophospholipid metabolism namespace: pathway def: "Metabolism of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [UPa:amorgat] xref: GO:0006650 "biological_process:glycerophospholipid metabolic process" is_a: UPa:UPA00939 ! membrane lipid metabolism relationship: uniprot_super_pathway UPa:UPA00939 ! membrane lipid metabolism [Term] id: UPa:UPA00941 name: N-acetylgalactosamine degradation namespace: pathway def: "Degradation of N-acetylgalactosamine." [UPa:amorgat] is_a: UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA00942 name: biological regulation namespace: pathway def: "Any process that modulates the frequency, rate or extent of any biological process, quality or function. [source: GO]." [UPa:amorgat] xref: GO:0065007 "biological_process:biological regulation" is_a: UPa:UPA00001 ! biological process [Term] id: UPa:UPA00943 name: signal transduction namespace: pathway def: "Signal transduction refers to any process by which a cell converts one kind of signal or stimulus into another. Most processes of signal transduction involve ordered sequences of biochemical reactions inside the cell, which are carried out by enzymes, activated by second messengers, resulting in a signal transduction pathway." [UPa:amorgat] xref: GO:0007165 "biological_process:signal transduction" is_a: UPa:UPA00942 ! biological regulation [Term] id: UPa:UPA00944 name: phosphatidylinositol signaling pathway namespace: pathway def: "Phosphatidylinositol is the substrate for a large number of enzymes which are involved in cell signaling because it can be phosphorylated by a variety of kinases on the hydroxyl groups 3, 4 and 5 on the inositol ring in seven different combinations." [UPa:amorgat] is_a: UPa:UPA00943 ! signal transduction relationship: uniprot_super_pathway UPa:UPA00943 ! signal transduction [Term] id: UPa:UPA00945 name: propanoyl-CoA degradation namespace: pathway def: "Degradation of propionyl-CoA." [UPa:amorgat] xref: KEGG:map00280 "Valine, leucine and isoleucine degradation" xref: KEGG:map00630 "Glyoxylate and dicarboxylate metabolism" xref: KEGG:map00640 "Propanoate metabolism" xref: KEGG:map00720 "Carbon fixation pathways in prokaryotes" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00498 ! metabolic intermediate degradation relationship: uniprot_super_pathway UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00946 name: propanoate degradation namespace: pathway def: "Degradation of propionic acid, an organic acid." [UPa:amorgat] synonym: "propionate degradation" EXACT [] synonym: "propionic acid degradation" EXACT [] xref: GO:0019543 {source="rdfmatch"} is_a: UPa:UPA00205 ! propanoate metabolism is_a: UPa:UPA00699 ! organic acid degradation relationship: uniprot_super_pathway UPa:UPA00698 ! organic acid metabolism [Term] id: UPa:UPA00947 name: glycerophospholipid biosynthesis namespace: pathway def: "Biosynthesis of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [UPa:amorgat] xref: GO:0046474 "biological_process:glycerophospholipid biosynthetic process" is_a: UPa:UPA00751 ! phospholipid biosynthesis is_a: UPa:UPA00938 ! membrane lipid biosynthesis [Term] id: UPa:UPA00948 name: phosphatidylserine biosynthesis namespace: pathway def: "Biosynthesis of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. [source: GO]." [UPa:amorgat] xref: GO:0006659 "biological_process:phosphatidylserine biosynthetic process" is_a: UPa:UPA00947 ! glycerophospholipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00085 ! phospholipid metabolism [Term] id: UPa:UPA00949 name: phosphatidylinositol metabolism namespace: pathway def: "Metabolism of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [source: GO]." [UPa:amorgat] xref: GO:0046488 "biological_process:phosphatidylinositol metabolic process" is_a: UPa:UPA00940 ! glycerophospholipid metabolism relationship: uniprot_super_pathway UPa:UPA00085 ! phospholipid metabolism [Term] id: UPa:UPA00950 name: spore coat biogenesis namespace: pathway def: "Biogenesis of spore coat, a complex multiprotein structure that plays an important role in spore germination and resistance to toxic chemicals. Other functions are assigned to the coat, from sensing the external environment through active enzymes present on its surface to protecting the spore from predation by phagocytic protozoans. In addition, the coat is a novel system for the display at the spore surface of heterologous antigens, enzymes, and bioactive molecules." [UPa:amorgat] xref: GO:0042244 "biological_process:spore wall assembly" is_a: UPa:UPA00932 ! cell surface structure biogenesis [Term] id: UPa:UPA00951 name: photorespiration namespace: pathway def: "Photorespiration involves three organelles: the chloroplast, the peroxisome, and the mitochondria. At conditions of low CO2 concentration and high O2 concentration, ribulose bisphosphate is oxidized to 3-phosphoglycerate and 2-phosphoglycolate. The two-carbon molecule, 2-phosphoglycolate is converted to glycine. The decarboxylation of two glycines generates serine, CO2 and NH3. Serine is further converted to 3-phosphoglycerate. 3-phosphoglycerate generated from photorespiration re-enters the CO2 fixation Calvin cycle. NH3 is re-fixed by glutamine synthetase. The outcome of photorespiration is loss of CO2 and energy in photosynthetic cells. The biological function of photorespiration is not clear. One possibility is that photorespiration is necessary under conditions of high light intensity and low CO2 concentration (i.e. when stomata is closed under water stress) to dissipate excess ATP and reducing power from the photosynthesis light reactions, thus to prevent damage to the photosynthetic apparatus. [MetaCyc]." [UPa:amorgat] synonym: "C2 pathway" EXACT [] synonym: "C2 photorespiratory carbon oxidation cycle" EXACT [] synonym: "oxidative photosynthetic carbon pathway" EXACT [] synonym: "PCO cycle" EXACT [] xref: GO:0009854 "biological_process:oxidative photosynthetic carbon pathway" xref: KEGG:map00260 "Glycine, serine and threonine metabolism" xref: KEGG:map00460 "Cyanoamino acid metabolism" xref: KEGG:map00561 "Glycerolipid metabolism" xref: KEGG:map00630 "Glyoxylate and dicarboxylate metabolism" xref: KEGG:map00670 "One carbon pool by folate" xref: KEGG:map00680 "Methane metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:PWY-181 is_a: UPa:UPA00091 ! photosynthesis relationship: uniprot_super_pathway UPa:UPA00091 ! photosynthesis [Term] id: UPa:UPA00952 name: proanthocyanidin biosynthesis namespace: pathway def: "Biosynthesis of proanthocyanidins (oligomeric proanthocyanidins or OPCs), a class of flavonoid complexes found in sea buckthorn oil and grape seeds and skin. Proanthocyanidin act as antioxidants (free radical scavengers) in the human body." [UPa:amorgat] xref: GO:0010023 "biological_process:proanthocyanidin biosynthetic process" is_a: UPa:UPA00154 ! flavonoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00709 ! flavonoid metabolism [Term] id: UPa:UPA00953 name: spore coat polysaccharide biosynthesis namespace: pathway def: "Biosynthesis of spore coat polysaccharides." [UPa:amorgat] is_a: UPa:UPA00950 ! spore coat biogenesis relationship: uniprot_super_pathway UPa:UPA00950 ! spore coat biogenesis [Term] id: UPa:UPA00954 name: vitamin D biosynthesis namespace: pathway def: "Biosynthesis of vitamin D, a group of fat-soluble prohormones, the two major forms of which are vitamin D2 (or ergocalciferol) and vitamin D3 (or cholecalciferol). The term vitamin D also refers to metabolites and other analogues of these substances. Vitamin D3 is produced in skin exposed to sunlight, specifically ultraviolet B radiation." [UPa:amorgat] xref: GO:0042368 "biological_process:vitamin D biosynthetic process" is_a: UPa:UPA00435 ! hormone biosynthesis relationship: uniprot_super_pathway UPa:UPA00435 ! hormone biosynthesis [Term] id: UPa:UPA00955 name: cholecalciferol biosynthesis namespace: pathway def: "Biosynthesis of cholecalciferol (vitamin D3)." [UPa:amorgat] synonym: "vitamin D(3) biosythesis" EXACT [] is_a: UPa:UPA00954 ! vitamin D biosynthesis relationship: uniprot_super_pathway UPa:UPA00435 ! hormone biosynthesis [Term] id: UPa:UPA00956 name: L-fucose metabolism namespace: pathway def: "Metabolism of the methylpentose L-fucose (6-deoxygalactose)." [UPa:amorgat] synonym: "6-deoxygalactose metabolism" EXACT [] xref: GO:0006004 "biological_process:fucose metabolic process" is_a: UPa:UPA00411 ! carbohydrate metabolism relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA00957 name: N-glycan metabolism namespace: pathway def: "Metabolism of asparagine (N)-linked oligosaccharides (N-glycans)." [UPa:amorgat] synonym: "N-linked oligosaccharide metabolism" EXACT [] is_a: UPa:UPA00441 ! glycan metabolism relationship: uniprot_super_pathway UPa:UPA00441 ! glycan metabolism [Term] id: UPa:UPA00958 name: LPS core biosynthesis namespace: pathway def: "Biosynthesis of the core region of bacterial lipopolysaccharides (LPS)." [UPa:amorgat] synonym: "lipopolysaccharide core biosynthesis" EXACT [] xref: GO:0009244 "biological_process:lipopolysaccharide core region biosynthetic process" is_a: UPa:UPA00030 ! lipopolysaccharide biosynthesis relationship: uniprot_super_pathway UPa:UPA00324 ! bacterial outer membrane biogenesis [Term] id: UPa:UPA00959 name: phosphorus metabolism namespace: pathway def: "Metabolic pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus.[source: GO]." [UPa:amorgat] xref: GO:0006793 "biological_process:phosphorus metabolic process" is_a: UPa:UPA00026 ! metabolism [Term] id: UPa:UPA00960 name: phosphonate biosynthesis namespace: pathway def: "Biosynthesis of phosphonates, i.e organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups." [UPa:amorgat] xref: GO:0032923 "biological_process:organic phosphonate biosynthetic process" xref: PMID:10571990 is_a: UPa:UPA00959 ! phosphorus metabolism relationship: uniprot_super_pathway UPa:UPA00959 ! phosphorus metabolism [Term] id: UPa:UPA00961 name: ginkgolide biosynthesis namespace: pathway def: "Biosynthesis of ginkgolide derivatives, biologically active terpenic lactones present in Ginkgo biloba. Ginkgolides have a diterpenoid structure, i.e. it has 20-carbon skeleton and are synthesized from geranylgeranyl pyrophosphate." [UPa:amorgat] is_a: UPa:UPA00423 ! terpene metabolism relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00962 name: L-cysteine metabolism namespace: pathway def: "Metabolism of L-cysteine (2-amino-3-mercaptopropanoic acid) , an hydrophilic natural amino-acids with a thiol sidechain." [UPa:amorgat] synonym: "2-amino-3-mercaptopropanoic acid metabolism" EXACT [] xref: GO:0006534 "biological_process:cysteine metabolic process" is_a: UPa:UPA00401 ! amino-acid metabolism [Term] id: UPa:UPA00963 name: cell wall polysaccharide biosynthesis namespace: pathway def: "Biosynthesis of polysaccharides that make up the cell wall." [UPa:amorgat] xref: GO:0045227 "biological_process:capsule polysaccharide biosynthetic process" is_a: UPa:UPA00547 ! cell wall biogenesis relationship: uniprot_super_pathway UPa:UPA00547 ! cell wall biogenesis [Term] id: UPa:UPA00964 name: butirosin biosynthesis namespace: pathway def: "Biosynthesis of butirosin, a water-soluble aminoglycosidic antibiotic complex isolated from fermentation filtrates of bacillus circulans." [UPa:amorgat] xref: GO:1901758 {source="rdfmatch"} xref: PMID:12374384 is_a: UPa:UPA00966 ! aminoglycoside antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00965 name: kanamycin biosynthesis namespace: pathway def: "Biosynthesis of kanamycin, an aminoglycoside antibiotic." [UPa:amorgat] xref: GO:1901133 {source="rdfmatch"} is_a: UPa:UPA00966 ! aminoglycoside antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00966 name: aminoglycoside antibiotic biosynthesis namespace: pathway def: "Biosynthesis of aminoglycoside, a group of antibiotics active against many aerobic gram-negative and some gram-positive bacteria. Aminoglycoside are mostly produced by fungi and contain an amino sugar, and amino-or guanido-substituted inositol ring which are attached by a glycosidic linkage to a hexose nucleus resulting in a polycationic and highly polar compound. T Common examples are streptomycin, gentamicin, amikacin, kanamycin, tobramycin, netilmicin, neomycin, framycetin." [UPa:amorgat] xref: GO:0030648 "biological_process:aminoglycoside antibiotic biosynthetic process" is_a: UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00967 name: gentamicin biosynthesis namespace: pathway def: "Biosynthesis of gentamicin, an aminoglycoside antibiotic." [UPa:amorgat] is_a: UPa:UPA00966 ! aminoglycoside antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00968 name: lividomycin biosynthesis namespace: pathway def: "Biosynthesis of lividomycin, an aminoglycoside antibiotic." [UPa:amorgat] is_a: UPa:UPA00966 ! aminoglycoside antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00969 name: neomycin biosynthesis namespace: pathway def: "Biosynthesis of neomycin, an aminoglycoside antibiotic." [UPa:amorgat] xref: GO:1901158 {source="rdfmatch"} is_a: UPa:UPA00966 ! aminoglycoside antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00970 name: paromomycin biosynthesis namespace: pathway def: "Biosynthesis of paromomycin, an aminoglycoside antibiotic." [UPa:amorgat] xref: GO:1901155 {source="rdfmatch"} is_a: UPa:UPA00966 ! aminoglycoside antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00971 name: tobramycin biosynthesis namespace: pathway def: "Biosynthesis of tobramycin, an aminoglycoside antibiotic." [UPa:amorgat] xref: GO:1901121 {source="rdfmatch"} is_a: UPa:UPA00966 ! aminoglycoside antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00972 name: ribostamycin biosynthesis namespace: pathway def: "Biosynthesis of ribostamycin, an aminoglycoside antibiotic." [UPa:amorgat] xref: GO:1901152 {source="rdfmatch"} is_a: UPa:UPA00966 ! aminoglycoside antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00973 name: LPS lipid A biosynthesis namespace: pathway def: "Biosynthesis of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues." [UPa:amorgat] synonym: "lipopolysaccharide lipid A biosynthesis" EXACT [] xref: GO:0009245 "biological_process:lipid A biosynthetic process" is_a: UPa:UPA00030 ! lipopolysaccharide biosynthesis is_a: UPa:UPA00506 ! glycolipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00324 ! bacterial outer membrane biogenesis [Term] id: UPa:UPA00974 name: pentalenolactone biosynthesis namespace: pathway def: "Biosynthesis of pentalenolactone, a sesquiterpenoid antibiotic, first isolated in 1957 from Streptomyces roseogriseus and subsequently found in the extracts of numerous Streptomyces species. Pentalenolactone has been shown to be active against both Gram-positive and Gram-negative bacteria as well as a variety of fungi and protozoa and to inhibit the replication of DNA viruses such as HSV-1 and HSV-2. Pentalenolactone also inhibits vascular smooth muscle cell proliferation." [UPa:amorgat] xref: GO:1901780 {source="rdfmatch"} xref: PMID:16681390 is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00449 ! sesquiterpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00975 name: prenylquinone biosynthesis namespace: pathway def: "Biosynthesis of prenylquinone, a group of benzoquinone (ubiquinone, plastoquinone) with isoprenyl side chain." [UPa:amorgat] xref: PMID:10198110 is_a: UPa:UPA00829 ! quinol/quinone biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00976 name: LOS core biosynthesis namespace: pathway def: "Biosynthesis of the core region of bacterial lipoolidosaccharides (LOS)." [UPa:amorgat] is_a: UPa:UPA00501 ! lipooligosaccharide biosynthesis relationship: uniprot_super_pathway UPa:UPA00324 ! bacterial outer membrane biogenesis [Term] id: UPa:UPA00977 name: S-layer biogenesis namespace: pathway def: "Biogenesis of S-layer structure, a crystalline protein layer surrounding some bacteria." [UPa:amorgat] xref: GO:0045232 "biological_process:S-layer organization" is_a: UPa:UPA00932 ! cell surface structure biogenesis relationship: uniprot_super_pathway UPa:UPA00932 ! cell surface structure biogenesis [Term] id: UPa:UPA00978 name: flagellum biogenesis namespace: pathway def: "Biogenesis (formation and assembly) of flagellum components. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer ." [UPa:amorgat] synonym: "flagella biogenesis" EXACT [] is_a: UPa:UPA00932 ! cell surface structure biogenesis [Term] id: UPa:UPA00979 name: calcium-dependent antibiotic biosynthesis namespace: pathway def: "Biosynthesis of the calcium-dependent antibiotics (CDAs). CDAs belong to the group of structurally related acidic lipopetide antibiotics, which include A54145, daptomycin, friulimicins and amphomycins. All of these nonribosomally biosynthesized lipopeptides contain N-terminal fatty acid side chains, which is a trans-2,3-epoxyhexanoyl moiety in the case of CDA, along with decapeptide lactone or lactam cores." [UPa:amorgat] xref: PMID:17322197 xref: PMID:17373765 is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA00980 name: colanic acid biosynthesis namespace: pathway def: "Biosynthesis of colanic acid (M-antigen), an exopolysaccharide common to many enterobacteria." [UPa:amorgat] synonym: "M-antigen biosynthesis" EXACT [] xref: GO:0009242 "biological_process:colanic acid biosynthetic process" is_a: UPa:UPA00631 ! exopolysaccharide biosynthesis relationship: uniprot_super_pathway UPa:UPA00631 ! exopolysaccharide biosynthesis [Term] id: UPa:UPA00981 name: quinolobactin biosynthesis namespace: pathway def: "Biosynthesis of quinolobactin (8-hydroxy-4-methoxy-quinaldic acid), a siderophore produced by some pseudomonas species." [UPa:amorgat] synonym: "8-hydroxy-4-methoxy-quinaldic acid biosynthesis" EXACT [] xref: PMID:10653708 xref: PMID:15066027 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA00982 name: limonene biosynthesis namespace: pathway def: "Biosynthesis of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. Limonene is the most widespread terpene in the world and is formed by more than 300 plants." [UPa:amorgat] synonym: "4-isopropenyl-1-methylcyclohexene biosynthesis" EXACT [] xref: GO:0046250 "biological_process:limonene biosynthetic process" is_a: UPa:UPA00717 ! monoterpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00983 name: (4R)-limonene biosynthesis namespace: pathway def: "Biosynthesis of D-limonene ((+)-4R-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [UPa:amorgat] synonym: "(+)-4R-isopropenyl-1-methylcyclohexene biosynthesis" EXACT [] synonym: "(+)-limonene biosynthesis" EXACT [] synonym: "alpha-limonene biosynthesis" EXACT [] synonym: "D-limonene biosynthesis" EXACT [] xref: KEGG:map00902 "Monoterpenoid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00982 ! limonene biosynthesis relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00984 name: (4S)-limonene biosynthesis namespace: pathway def: "Biosynthesis of L-limonene ((-)-4S-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [UPa:amorgat] synonym: "(-)-4S-isopropenyl-1-methylcyclohexene biosynthesis" EXACT [] synonym: "(-)-limonene biosyntesis" EXACT [] synonym: "beta-limonene biosynthesis" EXACT [] synonym: "L-limonene biosynthesis" EXACT [] xref: KEGG:map00902 "Monoterpenoid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00982 ! limonene biosynthesis relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00985 name: (-)-alpha-pinene biosynthesis namespace: pathway def: "Biosynthesis of (-)-alpha-pinene ((1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene), a bicyclic monoterpene. It is produced from geranyl pyrophosphate, via cyclisation of linaloyl pyrophosphate followed by loss of a proton from the carbocation equivalent." [UPa:amorgat] synonym: "(-)-alpha-pinene biosyntesis" EXACT [] synonym: "(1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene" EXACT [] xref: GO:0046248 "biological_process:alpha-pinene biosynthetic process" xref: KEGG:map00902 "Monoterpenoid biosynthesis" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00717 ! monoterpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00986 name: (-)-beta-pinene biosynthesis namespace: pathway def: "It is produced from geranyl pyrophosphate, via cyclisation of linaloyl pyrophosphate followed by loss of a proton from the carbocation equivalent." [UPa:amorgat] synonym: "(-)-beta-pinene biosyntesis" EXACT [] synonym: "(1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane" EXACT [] xref: KEGG:map00902 "Monoterpenoid biosynthesis" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" is_a: UPa:UPA00717 ! monoterpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00987 name: (4R)-limonene degradation namespace: pathway def: "Degradation of (4R)-limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [UPa:amorgat] synonym: "(+)-4R-isopropenyl-1-methylcyclohexene degradation" EXACT [] synonym: "(+)-limonene degradation" EXACT [] synonym: "alpha-limonene degradation" EXACT [] synonym: "D-limonene degradation" EXACT [] xref: KEGG:map00902 "Monoterpenoid biosynthesis" xref: KEGG:map00903 "Limonene and pinene degradation" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:10224006 is_a: UPa:UPA00888 ! limonene degradation relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA00988 name: 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis namespace: pathway def: "Biosynthesis of 5-methoxycarbonylmethyl-2-thiouridine-tRNA. The wobble modification, 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U), is required for the proper decoding of NNR codons in eukaryotes." [UPa:amorgat] synonym: "mcm(5)s(2)U-tRNA biosynthesis" EXACT [] synonym: "mcm5s2U-tRNA biosynthesis" EXACT [] xref: PMID:19151091 is_a: UPa:UPA00481 ! tRNA modification relationship: uniprot_super_pathway UPa:UPA00481 ! tRNA modification [Term] id: UPa:UPA00989 name: N(7)-methylguanine-tRNA biosynthesis namespace: pathway def: "Biosynthesis of N(7)-methylguanine-tRNA. 7-methylguanosine (m7G) modification of tRNA occurs widely in eukaryotes and bacteria, is nearly always found at position 46, and is one of the few modifications that confers a positive charge to the base." [UPa:amorgat] synonym: "m7G-tRNA biosynthesis" EXACT [] xref: PMID:12403464 is_a: UPa:UPA00481 ! tRNA modification relationship: uniprot_super_pathway UPa:UPA00481 ! tRNA modification [Term] id: UPa:UPA00990 name: L-ascorbate biosynthesis via GDP-alpha-D-mannose pathway namespace: pathway def: "Biosynthesis of L-ascorbic acid from GDP-D-mannose." [UPa:amorgat] synonym: "Smirnoff-Wheeler's pathway" EXACT [] xref: KEGG:map00053 "Ascorbate and aldarate metabolism" xref: KEGG:map00520 "Amino sugar and nucleotide sugar metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: MetaCyc:PWY-882 xref: PMID:11005203 xref: PMID:11337405 is_a: UPa:UPA00132 ! L-ascorbate biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00991 name: L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway namespace: pathway def: "Biosynthesis of L-ascorbic acid from UDP-glucuronic acid. This pathway occurs in most vertebrates, although not in guinea pigs and primates, including humans." [UPa:amorgat] xref: KEGG:map00040 "Pentose and glucuronate interconversions" xref: KEGG:map00053 "Ascorbate and aldarate metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: MetaCyc:PWY3DJ-35471 is_a: UPa:UPA00132 ! L-ascorbate biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00992 name: endocannabinoid biosynthesis namespace: pathway def: "Biosynthesis of endocannabinoid derivatives. Endocannabinoid are endogenous compounds that bind to cannabinoid receptors (cannabimimetic activity). They are structurally different from the cannabinoids which are primarily derived from plants." [UPa:amorgat] xref: PMID:12843414 is_a: UPa:UPA00435 ! hormone biosynthesis [Term] id: UPa:UPA00993 name: 2-arachidonoylglycerol biosynthesis namespace: pathway def: "Biosynthesis of 2-arachidonoylglycerol (2-AG), an endogenous lipid that activates brain canabinoid receptors. 2-arachidonoylglycerol is an endocannabinoid. There are two possible routes of 2-AG biosynthesis in neurons [PMID:12843414]. Phospholipase C (PLC)-mediated hydrolysis of membrane phospholipids may produce 1,2-diacylglycerol, which may be subsequently converted to 2-arachidonoylglycerol by diacylglycerol lipase (DGL) activity. Alternatively, phospholipase A1 (PLA1) may generate a lysophospholipid, which may be hydrolyzed to 2-arachidonoylglycerol by a lyso-PLC activity." [UPa:amorgat] synonym: "2-AG biosynthesis" EXACT [] synonym: "sn-2-arachidonoyl-glycerol biosynthesis" EXACT [] xref: PMID:12843414 is_a: UPa:UPA00495 ! glycerolipid biosynthesis is_a: UPa:UPA00992 ! endocannabinoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00435 ! hormone biosynthesis [Term] id: UPa:UPA00995 name: phylloquinone biosynthesis namespace: pathway def: "Biosynthesis of phylloquinone (also called vitamine K1 or phytonadione), a lipid-soluble molecule that belongs to the naphto-quinone family." [UPa:amorgat] synonym: "2-methyl-3-phytyl-1,4-naphthoquinone biosynthesis" EXACT [] synonym: "phytonadione biosynthesis" EXACT [] synonym: "vitamin K1 biosynthesis" EXACT [] xref: GO:0042372 "biological_process:phylloquinone biosynthetic process" is_a: UPa:UPA00829 ! quinol/quinone biosynthesis relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA00996 name: carbamoyl phosphate degradation namespace: pathway def: "Degradation of carbamoyl phosphate, a key metabolic intermediate." [UPa:amorgat] xref: GO:0035975 "biological_process:carbamoyl phosphate catabolic process" xref: KEGG:map00230 "Purine metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map01120 "Microbial metabolism in diverse environments" is_a: UPa:UPA00498 ! metabolic intermediate degradation relationship: uniprot_super_pathway UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA00997 name: proteasomal Pup-dependent pathway namespace: pathway def: "Degradation of proteins by hydrolysis of their peptide bonds. This process is initiated by the covalent attachment of pup (Prokaryotic Ubiquitin-like Protein), and mediated by the proteasome." [UPa:amorgat] synonym: "Prokaryotic Ubiquitin-like Protein (pup) fusion protein degradation pathway" EXACT [] xref: PMID:15659170 xref: PMID:18832610 xref: PMID:19028679 xref: PMID:19483713 is_a: UPa:UPA00468 ! protein degradation relationship: uniprot_super_pathway UPa:UPA00468 ! protein degradation [Term] id: UPa:UPA00998 name: protein pupylation namespace: pathway def: "Conjugation of pup (Prokaryotic Ubiquitin-like Protein) to a target protein via an isopeptide bond between the carboxyl terminus of pup and the epsilon-amino group of a lysine residue of the target protein." [UPa:amorgat] synonym: "prokaryotic ubiquitin-like protein conjugation" EXACT [] synonym: "pup conjugation" EXACT [] xref: GO:0070490 "biological_process:protein pupylation" xref: PMID:19282181 xref: PMID:19448618 is_a: UPa:UPA00460 ! protein modification relationship: uniprot_super_pathway UPa:UPA00460 ! protein modification [Term] id: UPa:UPA00999 name: pimeloyl-CoA biosynthesis namespace: pathway def: "Biosynthesis of 6-carboxyhexanoyl-CoA (pimeloyl-CoA), a precursor of biotin in some organisms." [UPa:amorgat] synonym: "6-carboxyhexanoyl-CoA biosynthesis" EXACT [] xref: KEGG:map00780 "Biotin metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00415 ! metabolic intermediate biosynthesis relationship: uniprot_super_pathway UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA01000 name: tetrahydrofolate metabolism namespace: pathway def: "Metabolism of tetrahydrofolate derivative compounds." [UPa:amorgat] synonym: "THF metabolism" EXACT [] xref: GO:0046653 "biological_process:tetrahydrofolate metabolic process" is_a: UPa:UPA00496 ! metabolic intermediate metabolism [Term] id: UPa:UPA01001 name: bacilysocin biosynthesis namespace: pathway def: "Biosynthesis of bacilysocin, a phospholipid antibiotic." [UPa:amorgat] xref: PMID:11796336 is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01002 name: polychlorinated biphenyl degradation namespace: pathway def: "Degradation of polychlorinated biphenyls xenobiotic compounds." [UPa:amorgat] xref: PMID:19476337 is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA01003 name: bacillaene biosynthesis namespace: pathway def: "Biosynthesis of bacillaene, a polyketide antibiotic." [UPa:amorgat] xref: PMID:17234808 xref: PMID:17886826 is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00473 ! polyketide biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01004 name: palatinose degradation namespace: pathway def: "Degradation of palatinose." [UPa:amorgat] xref: PMID:11274100 is_a: UPa:UPA00442 ! glycan degradation relationship: uniprot_super_pathway UPa:UPA00442 ! glycan degradation [Term] id: UPa:UPA01005 name: petrobactin biosynthesis namespace: pathway def: "Biosynthesis of petrobactin, a catecholate siderophore that functions in both iron acquisition and virulence in a murine model of anthrax. Petrobactin harbors unique 3,4-dihydroxybenzoyl iron-liganding groups." [UPa:amorgat] xref: PMID:17189355 xref: PMID:18955706 is_a: UPa:UPA00302 ! siderophore biosynthesis relationship: uniprot_super_pathway UPa:UPA00302 ! siderophore biosynthesis [Term] id: UPa:UPA01006 name: mannosylfructose biosynthesis namespace: pathway def: "Biosynthesis of mannosylfructose. This disaccharide has been first discovered as the major osmolyte in salt-tolerant strains of A.tumefaciens biotype I." [UPa:amorgat] xref: MetaCyc:PWY-6116 xref: PMID:17728402 xref: PMID:2254260 is_a: UPa:UPA01008 ! oligosaccharide biosynthesis relationship: uniprot_super_pathway UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA01007 name: oligosaccharide metabolism namespace: pathway def: "Metabolism of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages [GO:0009311]." [UPa:amorgat] xref: GO:0009311 "biological_process:oligosaccharide metabolic process" is_a: UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA01008 name: oligosaccharide biosynthesis namespace: pathway def: "Biosynthesis of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages [GO:0009312]." [UPa:amorgat] xref: GO:0009312 "biological_process:oligosaccharide biosynthetic process" is_a: UPa:UPA00412 ! carbohydrate biosynthesis is_a: UPa:UPA01007 ! oligosaccharide metabolism [Term] id: UPa:UPA01009 name: nicotinate metabolism namespace: pathway def: "Metabolism of nicotinic acid, also known as niacin or vitamin B3, a water-soluble vitamin." [UPa:amorgat] synonym: "niacin metabolism" EXACT [] synonym: "nicotinic acid metabolism" EXACT [] synonym: "vitamin B3 metabolism" EXACT [] xref: KEGG:map00760 "Nicotinate and nicotinamide metabolism" xref: KEGG:map01100 "Metabolic pathways" is_a: UPa:UPA00398 ! cofactor metabolism relationship: uniprot_super_pathway UPa:UPA00399 ! cofactor biosynthesis [Term] id: UPa:UPA01010 name: nicotinate degradation namespace: pathway def: "Degradation of nicotinate also known as niacin or vitamin B3, a water-soluble vitamin." [UPa:amorgat] synonym: "niacin degradation" EXACT [] synonym: "nicotinic acid degradation" EXACT [] synonym: "vitamin B3 degradation" EXACT [] xref: KEGG:map00760 "Nicotinate and nicotinamide metabolism" xref: MetaCyc:PWY-5055 xref: PMID:16894175 is_a: UPa:UPA00483 ! cofactor degradation is_a: UPa:UPA01009 ! nicotinate metabolism relationship: uniprot_super_pathway UPa:UPA00483 ! cofactor degradation [Term] id: UPa:UPA01011 name: 4-chlorobenzoate degradation namespace: pathway def: "Degradation of 4-chlorobenzoate (4-CBA) by certain soil bacteria. 4-chlorobenzoate is not known to be a natural product but is introduced in the environement through its use as a precursor in the synthesis of dye stuffs, pigments and pharmaceuticals." [UPa:amorgat] synonym: "4-CBA degradation" EXACT [] synonym: "4-chlorobenzoic acid degradation" EXACT [] xref: KEGG:map00130 "Ubiquinone and other terpenoid-quinone biosynthesis" xref: KEGG:map00362 "Benzoate degradation" xref: KEGG:map00364 "Fluorobenzoate degradation" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:PWY-6215 xref: PMID:7765837 is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA01012 name: L-aspartate biosynthesis namespace: pathway def: "Biosynthesis of L-aspartate amino-acid from oxaloacetate, an intermediate of the TCA cycle, by a transamination reaction with glutamate. L-aspartate is a constituent of proteins and participates in several other biosyntheses as purine and pyrimidine nucleotide, NAD, phosphopanthothenate and other amino acids." [UPa:amorgat] xref: GO:0006532 "biological_process:aspartate biosynthetic process" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00710 "Carbon fixation in photosynthetic organisms" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:ASPARTATESYN-PWY is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA01013 name: L-glutamine biosynthesis namespace: pathway def: "Biosynthesis of L-glutamine amino-acid." [UPa:amorgat] xref: GO:0006542 "biological_process:glutamine biosynthetic process" xref: KEGG:map00250 "Alanine, aspartate and glutamate metabolism" xref: KEGG:map00330 "Arginine and proline metabolism" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: MetaCyc:GLNSYN-PWY is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA01014 name: ergothioneine biosynthesis namespace: pathway def: "Biosynthesis of ergothioneine. Ergothioneine is a histidine-derived thiol of bacterial and fungal origin that has also been isolated from animal and human tissue. Ergothioneine has antioxidant properties." [UPa:amorgat] xref: GO:0052699 "biological_process:ergothioneine biosynthetic process" xref: MetaCyc:PWY-7255 xref: PMID:20420449 is_a: UPa:UPA00406 ! nonprotein amino-acid biosynthesis is_a: UPa:UPA00490 ! histidine metabolism is_a: UPa:UPA00521 ! organosulfur biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA01015 name: anthranilate degradation namespace: pathway def: "Degradation of anthranilate (2-aminobenzoate). Anthranilate is an intermediate in the degradation of many compounds, such as tryptophan, o-nitrobenzoate, quinaldine, carbazole, and those containing an indole moiety." [UPa:amorgat] xref: GO:0043421 "biological_process:anthranilate catabolic process" is_a: UPa:UPA00433 ! aromatic compound metabolism relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA01016 name: anthranilate degradation via hydroxylation namespace: pathway def: "Degradation of anthranilate via hydroxylation pathway. This aerobic pathway converts anthranilate to catechol in a single step." [UPa:amorgat] xref: KEGG:map00627 "Aminobenzoate degradation" xref: KEGG:map00910 "Nitrogen metabolism" xref: KEGG:map01120 "Microbial metabolism in diverse environments" xref: PMID:11114907 xref: PMID:13129960 is_a: UPa:UPA01015 ! anthranilate degradation relationship: uniprot_super_pathway UPa:UPA00433 ! aromatic compound metabolism [Term] id: UPa:UPA01017 name: xanthan biosynthesis namespace: pathway def: "Biosynthesis of xanthan, an industrially important exopolysaccharide produced by the phytopathogenic, gram-negative bacterium Xanthomonas campestris pv. campestris. Xanthan is composed of polymerized pentasaccharide repeating units which are assembled by the sequential addition of glucose-1-phosphate, glucose, mannose, glucuronate, and mannose on a polyprenol phosphate carrier." [UPa:amorgat] xref: PMID:14736729 xref: PMID:18596046 xref: PMID:21367879 xref: PMID:9537354 is_a: UPa:UPA00484 ! glycan biosynthesis relationship: uniprot_super_pathway UPa:UPA00484 ! glycan biosynthesis [Term] id: UPa:UPA01018 name: tylosin biosynthesis namespace: pathway def: "Biosynthesis of tylosin, a macrolide antibiotic produced by Streptomyces fradiae. The structure of tylosin is a 16-atom polyketide lactone (tylactone) with 3 sugars atached (D-mycaminose, &-deoxy-D-allose and L-mycaose)." [UPa:amorgat] xref: PMID:10510490 xref: PMID:11816964 xref: PMID:9451830 is_a: UPa:UPA00473 ! polyketide biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01019 name: mycinamicin biosynthesis namespace: pathway def: "Biosynthesis of mycinamicin." [UPa:amorgat] xref: PMID:19415708 is_a: UPa:UPA00473 ! polyketide biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01020 name: dafachronic acid biosynthesis namespace: pathway def: "Biosynthesis of dafachronic acids (DAs), which are steroid hormones and ligands for the nuclear receptor DAF-12." [UPa:amorgat] xref: PMID:20178781 is_a: UPa:UPA00440 ! steroid hormone biosynthesis relationship: uniprot_super_pathway UPa:UPA00440 ! steroid hormone biosynthesis [Term] id: UPa:UPA01021 name: neopentalenolactone biosynthesis namespace: pathway def: "Biosynthesis of neopentalenolactone, a sesquiterpenoid antibiotic." [UPa:amorgat] xref: PMID:21250661 is_a: UPa:UPA00295 ! antibiotic biosynthesis is_a: UPa:UPA00449 ! sesquiterpene biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01022 name: branched-chain fatty acid metabolism namespace: pathway def: "Metabolism of branched-chain fatty acid compounds." [UPa:amorgat] is_a: UPa:UPA00199 ! fatty acid metabolism relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA01023 name: 15-methylhexadecasphinganine base metabolism namespace: pathway def: "Metabolism of 15-methylhexadecasphinganine base derivatives." [UPa:amorgat] is_a: UPa:UPA00222 ! sphingolipid metabolism relationship: uniprot_super_pathway UPa:UPA00222 ! sphingolipid metabolism [Term] id: UPa:UPA01024 name: octadecasphinganine base metabolism namespace: pathway def: "Metabolism of octadecasphinganine base derivatives." [UPa:amorgat] is_a: UPa:UPA00222 ! sphingolipid metabolism relationship: uniprot_super_pathway UPa:UPA00222 ! sphingolipid metabolism [Term] id: UPa:UPA01025 name: dodecasphinganine base metabolism namespace: pathway def: "Metabolism of dodecasphinganine base derivatives." [UPa:amorgat] is_a: UPa:UPA00222 ! sphingolipid metabolism relationship: uniprot_super_pathway UPa:UPA00222 ! sphingolipid metabolism [Term] id: UPa:UPA01026 name: plastidic glycolysis namespace: pathway def: "In plants glycolysis occurs in both cytosol and plastids, with reactions in the different compartments catalysed by separate isoenzymes. In chloroplasts, glycolysis is most active in conjunction with the breakdown of starch to form sucrose for export to non-photosynthetic tissues. There is some doubt about the occurrence of phosphoglycerate mutase in chloroplasts, and therefore the main products of the glycolytic reactions may be triose phosphates and 3-PGA. These could be exported through the Pi translocator in the chloroplast envelope to the cytosol, where sucrose synthesis takes place. In photosynthetic cells, the triose phosphate exported to the cytosol for sucrose synthesis could also enter the glycolytic pathway directly to provide mitochondrial substrates. [http://plantsinaction.science.uq.edu.au/edition1/?q=content/2-4-2-glycolytic-pathway]." [UPa:amorgat] is_a: UPa:UPA00413 ! carbohydrate degradation relationship: uniprot_super_pathway UPa:UPA00413 ! carbohydrate degradation [Term] id: UPa:UPA01027 name: spirilloxanthin biosynthesis namespace: pathway def: "Spirilloxanthin is a carotenoid synthesized by the photosynthetic non-sulfur purple bacterium Rhodospirillum rubrum. It was shown to be aggregated in large particles (apparent MW > 600 kDa) and was not associated with a specific protein. This acyclic, methylated carotenoid, as well as spheroidene, are accessory pigments, in the light-harvesting and reaction-center complexes in Rhodospirillum rubrum." [UPa:amorgat] xref: PMID:10880364 xref: PMID:12745254 xref: PMID:22623302 is_a: UPa:UPA00386 ! carotenoid biosynthesis relationship: uniprot_super_pathway UPa:UPA00386 ! carotenoid biosynthesis [Term] id: UPa:UPA01028 name: L-pyrrolysine biosynthesis namespace: pathway def: "L-pyrrolysine (abbreviated as Pyl or O) is a naturally occurring, genetically coded amino acid used by some methanogenic archaea and bacterium in enzymes that are part of their methane-producing metabolism. It forms part of an unusual genetic code in these organisms, and is considered the 22nd proteinogenic amino acid. It is necessary for all of the known pathways by which methane is formed from methylamines [PMID:21550296]. L-pyrrolysine is similar to lysine, but with an added pyrroline ring linked to the end of the lysine side chain. Pyrrolysine is synthesized in vivo by joining two molecules of L-lysine. One molecule of lysine is first converted to (3R)-3-Methyl-D-ornithine, which is then ligated to a second lysine. An amino group is eliminated, followed by cyclization and dehydration step to yield L-pyrrolysine." [UPa:amorgat] xref: GO:0071524 "biological_process:pyrrolysine biosynthetic process" xref: MetaCyc:PWY-6994 xref: PMID:17204561 xref: PMID:21455182 xref: PMID:21550296 is_a: UPa:UPA00403 ! proteinogenic amino-acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00402 ! amino-acid biosynthesis [Term] id: UPa:UPA01029 name: rifamycin B biosynthesis namespace: pathway def: "Biosynthesis of rifamycin B. The rifamycins are an important family of ansamycin antibiotics with anti-mycobacterial activity. rifamycin B is synthesized either naturally by the bacterium Amycolatopsis mediterranei (formerly Streptomyces mediterranei, Nocardia mediterranei) or artificially." [UPa:amorgat] xref: MetaCyc:PWY-5984 xref: PMID:16233407 is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01030 name: 4-nitrophenol degradation namespace: pathway def: "Degradation of 4-nitrophenol (also called p-nitrophenol or 4-hydroxynitrobenzene). 4-nitrophenol is a phenolic compound that has a nitro group at the opposite position of hydroxy group on the benzene ring." [UPa:amorgat] xref: GO:0046196 "biological_process:4-nitrophenol catabolic process" xref: MetaCyc:PWY-5487 xref: MetaCyc:PWY-5488 is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA01031 name: carbazole degradation namespace: pathway def: "Degradation of carbazole. Carbazole is an aromatic heterocyclic organic compound. It has a tricyclic structure, consisting of two six-membered benzene rings fused on either side of a five-membered nitrogen-containing ring." [UPa:amorgat] xref: GO:0046232 "biological_process:carbazole catabolic process" xref: MetaCyc:PWY-6550 is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA01032 name: 1,8-cineol degradation namespace: pathway def: "Degradation of 1,8-cineol (eucalyptol). 1,8-cineole is a cyclic monoterpene containing an internal ether linkage. It is found in the oil from the leaves of Eucalyptus radiata var. Australiana and is used in the fragrance and flavor industries. Microorganisms metabolizing 1,8-cineole as sole carbon source must cleave both the ring and ether linkages." [UPa:amorgat] synonym: "eucalyptol degradation" EXACT [] xref: GO:0046232 "biological_process:carbazole catabolic process" xref: MetaCyc:6-HYDROXYCINEOLE-DEGRADATION-PWY is_a: UPa:UPA00137 ! monoterpene degradation relationship: uniprot_super_pathway UPa:UPA00423 ! terpene metabolism [Term] id: UPa:UPA01033 name: 4-chloronitrobenzene degradation namespace: pathway def: "Degradation of 4-chloronitrobenzene. 4-Nitrochlorobenzene is a common intermediate in the production of a number of industrially useful compounds, including common antioxidants found in rubber." [UPa:amorgat] xref: MetaCyc:PWY-5645 xref: PMID:21803909 is_a: UPa:UPA00105 ! xenobiotic degradation is_a: UPa:UPA00706 ! aromatic compound degradation relationship: uniprot_super_pathway UPa:UPA00105 ! xenobiotic degradation [Term] id: UPa:UPA01034 name: aminocoumarin biosynthesis namespace: pathway def: "The aminocoumarin antibiotics comprise three classical compounds: novobiocin, clorobiocin and coumermycin A1. They are potent inhibitors of gyrase, competing with ATP for binding to the B subunit of DNA gyrase and thereby inhibiting the ATP-dependent DNA supercoiling catalysed by gyrase [PMID:10093705,PMID:12570764]. All three are produced by different Streptomyces strains [PMID:10770754], [PMID:11036020], [PMID:12480894] The novobiocin molecule comprises three structural moieties: the deoxy sugar noviose, a substituted 3-aminocoumarin moiety and a 3-prenylated 4-hydroxybenzoate moiety. Noviose is related to L-rhamnose, but shows an unusual 5,5-dimethyl structure and carries a carbamyl group at 3-OH and a methyl group at 4-OH. The aminocoumarin ring is substituted with hydroxy groups in positions 3 and 7. Novobiocin and coumermycin A1 carry a methyl group at position 8 of the aminocoumarin unit, while clorobiocin (also called chlorobiocin) is chlorinated in this position. In clorobiocin and coumermycin A1, the 3-OH of the deoxy sugar is connected with a 5-methylpyrrole-2-carboxyl moiety rather than with a carbamyl group. While clorobiocin contains the same prenylated 4-hydroxybenzoate moiety as novobiocin, the coumermycin A1 molecule contains a central 3-methylpyrrole-2,4-dicarboxylic acid moiety, which links two aminocoumarin-deoxy sugar assemblies in a nearly but not completely symmetrical fashion [PMID:16868863]." [UPa:amorgat] xref: PMID:10093705 xref: PMID:10770754 xref: PMID:11036020 xref: PMID:12480894 xref: PMID:12570764 xref: PMID:16868863 is_a: UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01035 name: novobiocin biosynthesis namespace: pathway def: "Biosynthesis of novobiocin. The novobiocin molecule comprises three structural moieties: the deoxy sugar noviose, a substituted 3-aminocoumarin moiety and a 3-prenylated 4-hydroxybenzoate moiety. Noviose is related to L-rhamnose, but shows an unusual 5,5-dimethyl structure and carries a carbamyl group at 3-OH and a methyl group at 4-OH. The aminocoumarin ring is substituted with hydroxy groups in positions 3 and 7. Novobiocin and coumermycin A1 carry a methyl group at position 8 of the aminocoumarin unit, while clorobiocin (also called chlorobiocin) is chlorinated in this position. In clorobiocin and coumermycin A1, the 3-OH of the deoxy sugar is connected with a 5-methylpyrrole-2-carboxyl moiety rather than with a carbamyl group. While clorobiocin contains the same prenylated 4-hydroxybenzoate moiety as novobiocin, the coumermycin A1 molecule contains a central 3-methylpyrrole-2,4-dicarboxylic acid moiety, which links two aminocoumarin-deoxy sugar assemblies in a nearly but not completely symmetrical fashion." [UPa:amorgat] xref: PMID:10770754 xref: PMID:16868863 is_a: UPa:UPA01034 ! aminocoumarin biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01036 name: kanosamine biosynthesis namespace: pathway def: "Biosynthesis of kanosamine, a naturally occurring antibiotic and component of oligosaccharide antibiotics such as kanamycin." [UPa:amorgat] xref: PMID:23586652 is_a: UPa:UPA00295 ! antibiotic biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01037 name: saturated fatty acid biosynthesis namespace: pathway def: "Biosynthesis of saturated fatty acids." [UPa:amorgat] is_a: UPa:UPA00094 ! fatty acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA01038 name: monounsaturated fatty acid biosynthesis namespace: pathway def: "Biosynthesis of mono unsaturated fatty acids." [UPa:amorgat] xref: GO:1903966 {source="rdfmatch"} is_a: UPa:UPA00094 ! fatty acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA01039 name: branched-chain fatty acid biosynthesis namespace: pathway def: "Biosynthesis of branched fatty acids." [UPa:amorgat] is_a: UPa:UPA00094 ! fatty acid biosynthesis relationship: uniprot_super_pathway UPa:UPA00436 ! lipid metabolism [Term] id: UPa:UPA01040 name: carminomycin biosynthesis namespace: pathway def: "Biosynthesis of carminomycin, a potent antitumor anthracycline antibiotic." [UPa:amorgat] is_a: UPa:UPA00127 ! anthracycline biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01041 name: doxorubicin biosynthesis namespace: pathway def: "Biosynthesis of doxorubicin, a potent antitumor anthracycline antibiotic." [UPa:amorgat] is_a: UPa:UPA00127 ! anthracycline biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01042 name: rhodomycin biosynthesis namespace: pathway def: "Biosynthesis of rhodomycin, a potent antitumor anthracycline antibiotic." [UPa:amorgat] is_a: UPa:UPA00127 ! anthracycline biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01043 name: aclacinomycin biosynthesis namespace: pathway def: "Biosynthesis of aclacinomycin, a potent antitumor anthracycline antibiotic." [UPa:amorgat] is_a: UPa:UPA00127 ! anthracycline biosynthesis relationship: uniprot_super_pathway UPa:UPA00295 ! antibiotic biosynthesis [Term] id: UPa:UPA01044 name: xyloglucan metabolism namespace: pathway def: "Metabolism of xyloglucan, a hemicellulose that occurs in the primary cell wall of all vascular plants." [UPa:amorgat] xref: GO:0010411 "biological_process:xyloglucan metabolic process" is_a: UPa:UPA00001 ! biological process relationship: uniprot_super_pathway UPa:UPA00444 ! glucan metabolism [Term] id: UPa:UPA01045 name: xyloglucan degradation namespace: pathway def: "Degradation of xyloglucan, a hemicellulose that occurs in the primary cell wall of all vascular plants." [UPa:amorgat] xref: GO:2000899 "biological_process:xyloglucan catabolic process" is_a: UPa:UPA00350 ! beta-D-glucan degradation is_a: UPa:UPA01044 ! xyloglucan metabolism relationship: uniprot_super_pathway UPa:UPA00444 ! glucan metabolism [Term] id: UPa:UPA01046 name: D-galacturonate metabolism namespace: pathway def: "Metabolism of D-galacturonate, a component of pectin." [UPa:amorgat] xref: GO:0046396 "biological_process:D-galacturonate metabolic process" is_a: UPa:UPA00411 ! carbohydrate metabolism [Term] id: UPa:UPA01047 name: D-galacturonate degradation namespace: pathway def: "Degradation of D-galacturonate, a component of pectin. For the microbial catabolism, three different pathways have been described, (i) a reductive pathway, (ii) an isomerase pathway, (iii) an oxidative pathway." [UPa:amorgat] xref: GO:0019698 "biological_process:D-galacturonate catabolic process" xref: PMID:19159926 is_a: UPa:UPA00857 ! carbohydrate acid metabolism is_a: UPa:UPA01046 ! D-galacturonate metabolism [Term] id: UPa:UPA01048 name: D-galacturonate degradation via prokaryotic reductive pathway namespace: pathway def: "The prokaryotic degradation of D-galacturonate via the reductive pathway." [UPa:amorgat] xref: PMID:19159926 is_a: UPa:UPA01047 ! D-galacturonate degradation relationship: uniprot_super_pathway UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA01049 name: D-galacturonate degradation via prokaryotic isomerase pathway namespace: pathway def: "The prokaryotic degradation of D-galacturonate via the isomerase pathway." [UPa:amorgat] xref: PMID:19159926 is_a: UPa:UPA01047 ! D-galacturonate degradation relationship: uniprot_super_pathway UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA01050 name: D-galacturonate degradation via prokaryotic oxidative pathway namespace: pathway def: "The prokaryotic degradation of D-galacturonate via the oxidative pathway." [UPa:amorgat] xref: PMID:19159926 xref: PMID:22493433 xref: PMID:24450804 is_a: UPa:UPA01047 ! D-galacturonate degradation relationship: uniprot_super_pathway UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA01051 name: D-galacturonate degradation via eukaryotic pathway namespace: pathway def: "The Degradation of D-galacturonate in eukaryotes. Yeast and mould can grow with d-galacturonic acid as a sole carbon source; however, a pathway different from the prokaryotic pathways is used." [UPa:amorgat] xref: PMID:19159926 is_a: UPa:UPA01047 ! D-galacturonate degradation relationship: uniprot_super_pathway UPa:UPA00857 ! carbohydrate acid metabolism [Term] id: UPa:UPA01052 name: glycosphingolipid biosynthesis namespace: pathway def: "Biosynthesis of glycosphingolipids, a subtype of glycolipids containing the amino alcohol sphingosine. Glycosphingolipids (GSLs) are found in the cell membranes of organisms from bacteria to man, and are the major glycans of the vertebrate brain, where more than 80% of glycoconjugates are in the form of glycolipids." [UPa:amorgat] xref: GO:0006688 {source="rdfmatch"} xref: PMID:10092602 xref: PMID:10207017 xref: PMID:10521438 xref: PMID:10702226 xref: PMID:10748143 xref: PMID:10837462 xref: PMID:10854427 xref: PMID:10854428 xref: PMID:10993897 xref: PMID:11283017 xref: PMID:11341836 xref: PMID:11384981 xref: PMID:8195250 xref: PMID:8631981 xref: PMID:8910600 xref: PMID:9405390 xref: PMID:9593693 xref: PMID:9792633 xref: PMID:9822625 is_a: UPa:UPA00506 ! glycolipid biosynthesis relationship: uniprot_super_pathway UPa:UPA00505 ! glycolipid metabolism [Term] id: UPa:UPA01053 name: phylloquinone metabolism namespace: pathway def: "Metabolism of phylloquinone (also called vitamine K1 or phytonadione), a lipid-soluble molecule that belongs to the naphto-quinone family." [UPa:amorgat] synonym: "2-methyl-3-phytyl-1,4-naphthoquinone metabolism" EXACT [] synonym: "phytonadione metabolism" EXACT [] synonym: "vitamin K1 metabolism" EXACT [] xref: GO:0042374 "biological_process:phylloquinone metabolic process" is_a: UPa:UPA01055 ! quinol/quinone metabolism [Term] id: UPa:UPA01054 name: phylloquinone degradation namespace: pathway def: "Degradation of phylloquinone (also called vitamine K1 or phytonadione), a lipid-soluble molecule that belongs to the naphto-quinone family." [UPa:amorgat] synonym: "2-methyl-3-phytyl-1,4-naphthoquinone degradation" EXACT [] synonym: "phytonadione degradation" EXACT [] synonym: "vitamin K1 degradation" EXACT [] xref: GO:0042376 "biological_process:phylloquinone catabolic process" xref: PMID:24138531 is_a: UPa:UPA01053 ! phylloquinone metabolism is_a: UPa:UPA01056 ! quinol/quinone degradation relationship: uniprot_super_pathway UPa:UPA00483 ! cofactor degradation [Term] id: UPa:UPA01055 name: quinol/quinone metabolism namespace: pathway def: "Metabolism of quinol/quinone cofactors, such as menaquinone (vitamin K2), ubiquinone (coenzyme Q) or phylloquinone (vitamin K1)." [UPa:amorgat] synonym: "quinone cofactor metabolism" EXACT [] xref: GO:1901661 "biological_process:quinone metabolic process" is_a: UPa:UPA00398 ! cofactor metabolism [Term] id: UPa:UPA01056 name: quinol/quinone degradation namespace: pathway def: "Degradation of quinone cofactors, such as menaquinone (vitamin K2), ubiquinone (coenzyme Q) or phylloquinone (vitamin K1)." [UPa:amorgat] synonym: "quinone cofactor degradation" EXACT [] xref: GO:1901662 "biological_process:quinone catabolic process" is_a: UPa:UPA00483 ! cofactor degradation is_a: UPa:UPA01055 ! quinol/quinone metabolism [Term] id: UPa:UPA01057 name: 1,4-dihydroxy-2-naphthoate biosynthesis namespace: pathway def: "Biosynthesis of 1,4-dihydroxy-2-naphthoate, the naphtalenic intermediate in the biosynthesis of several quinol/quinone cofactors such as menaquinone (vitamin K2) or phylloquinone (vitamin K1)." [UPa:amorgat] xref: KEGG:map00130 "Ubiquinone and other terpenoid-quinone biosynthesis" xref: KEGG:map01053 "Biosynthesis of siderophore group nonribosomal peptides" xref: KEGG:map01100 "Metabolic pathways" xref: KEGG:map01110 "Biosynthesis of secondary metabolites" xref: PMID:16617180 xref: PMID:23564174 is_a: UPa:UPA00829 ! quinol/quinone biosynthesis relationship: uniprot_super_pathway UPa:UPA01055 ! quinol/quinone metabolism [Term] id: UPa:UPA01058 name: cholesterol degradation namespace: pathway def: "The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids." [UPa:amorgat] xref: GO:0006707 "biological_process:cholesterol catabolic process" is_a: UPa:UPA00296 ! cholesterol metabolism relationship: uniprot_super_pathway UPa:UPA00504 ! steroid metabolism [Term] id: UPa:UPC00000 name: compound namespace: compound def: "A chemical compound involved in a UniPathway pathway." [] xref: CHEBI:24431 [Term] id: UPa:UPC00001 name: H(2)O namespace: compound synonym: "H2O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/H2O/h1H2" RELATED InChI [UPa:] xref: CHEBI:15377 xref: KEGG:C00001 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00002 name: ATP namespace: compound synonym: "C10H16N5O13P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15422 xref: KEGG:C00002 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00003 name: NAD(+) namespace: compound synonym: "C21H28N7O14P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p+1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15846 xref: KEGG:C00003 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00004 name: NADH namespace: compound synonym: "C21H29N7O14P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16908 xref: KEGG:C00004 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00005 name: NADPH namespace: compound synonym: "C21H30N7O17P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C21H30N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16474 xref: KEGG:C00005 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00006 name: NADP(+) namespace: compound synonym: "C21H29N7O17P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/p+1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18009 xref: KEGG:C00006 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00007 name: O(2) namespace: compound synonym: "InChI=1S/O2/c1-2" RELATED InChI [UPa:] synonym: "O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "oxygen" EXACT [KEGG:KEGG] xref: CHEBI:15379 xref: CHEBI:25805 xref: KEGG:C00007 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00008 name: ADP namespace: compound synonym: "C10H15N5O10P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16761 xref: KEGG:C00008 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00009 name: phosphate namespace: compound synonym: "H3O4P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)" RELATED InChI [UPa:] synonym: "orthophosphate" EXACT [KEGG:KEGG] xref: CHEBI:18367 xref: CHEBI:26078 xref: KEGG:C00009 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00010 name: CoA namespace: compound synonym: "C21H36N7O16P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "coenzyme A" EXACT [KEGG:KEGG] synonym: "InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16+,20-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15346 xref: KEGG:C00010 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00011 name: CO(2) namespace: compound synonym: "CO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/CO2/c2-1-3" RELATED InChI [UPa:] xref: CHEBI:16526 xref: KEGG:C00011 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00013 name: diphosphate namespace: compound synonym: "H4O7P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)" RELATED InChI [UPa:] synonym: "pyrophosphate" EXACT [KEGG:KEGG] xref: CHEBI:18361 xref: CHEBI:29888 xref: KEGG:C00013 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00014 name: NH(3) namespace: compound synonym: "H3N" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/H3N/h1H3" RELATED InChI [UPa:] xref: CHEBI:16134 xref: KEGG:C00014 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00015 name: UDP namespace: compound synonym: "C9H14N2O12P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17659 xref: KEGG:C00015 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00016 name: FAD namespace: compound synonym: "C27H33N9O15P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16238 xref: KEGG:C00016 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00018 name: pyridoxal 5'-phosphate namespace: compound synonym: "C8H10NO6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)" RELATED InChI [UPa:] xref: CHEBI:18405 xref: KEGG:C00018 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00019 name: S-adenosyl-L-methionine namespace: compound synonym: "C15H22N6O5S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27?/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15414 xref: CHEBI:67040 xref: KEGG:C00019 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00020 name: AMP namespace: compound synonym: "C10H14N5O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16027 xref: KEGG:C00020 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00021 name: S-adenosyl-L-homocysteine namespace: compound synonym: "C14H20N6O5S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16680 xref: KEGG:C00021 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00022 name: pyruvate namespace: compound synonym: "C3H4O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)" RELATED InChI [UPa:] xref: CHEBI:15361 xref: CHEBI:32816 xref: KEGG:C00022 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00024 name: acetyl-CoA namespace: compound synonym: "C23H38N7O17P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/t13-,16-,17-,18+,22-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15351 xref: KEGG:C00024 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00025 name: L-glutamate namespace: compound synonym: "C5H9NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16015 xref: KEGG:C00025 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00026 name: 2-oxoglutarate namespace: compound synonym: "C5H6O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:16810 xref: CHEBI:30915 xref: KEGG:C00026 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00027 name: H(2)O(2) namespace: compound synonym: "H2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "hydrogen peroxide" EXACT [KEGG:KEGG] synonym: "InChI=1S/H2O2/c1-2/h1-2H" RELATED InChI [UPa:] xref: CHEBI:16240 xref: KEGG:C00027 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00028 name: acceptor namespace: compound xref: CHEBI:15339 xref: KEGG:C00028 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00029 name: UDP-alpha-D-glucose namespace: compound synonym: "C15H24N2O17P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1" RELATED InChI [UPa:] synonym: "UDP-glucose" EXACT [KEGG:KEGG] xref: CHEBI:18066 xref: CHEBI:46229 xref: KEGG:C00029 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00030 name: reduced acceptor namespace: compound synonym: "hydrogen donor" EXACT [KEGG:KEGG] xref: CHEBI:17499 xref: KEGG:C00030 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00031 name: D-glucose namespace: compound synonym: "C6H12O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:4167 xref: KEGG:C00031 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00032 name: protoheme namespace: compound synonym: "C34H32FeN4O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;" RELATED InChI [UPa:] xref: CHEBI:17627 xref: CHEBI:26355 xref: CHEBI:30413 xref: KEGG:C00032 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00033 name: acetate namespace: compound synonym: "C2H4O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)" RELATED InChI [UPa:] xref: CHEBI:15366 xref: CHEBI:30089 xref: KEGG:C00033 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00035 name: GDP namespace: compound synonym: "C10H15N5O11P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17552 xref: KEGG:C00035 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00036 name: oxaloacetate namespace: compound synonym: "C4H4O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)" RELATED InChI [UPa:] xref: CHEBI:16452 xref: CHEBI:30744 xref: KEGG:C00036 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00037 name: glycine namespace: compound synonym: "C2H5NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)" RELATED InChI [UPa:] xref: CHEBI:15428 xref: KEGG:C00037 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00040 name: acyl-CoA namespace: compound xref: CHEBI:17984 xref: KEGG:C00040 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00041 name: L-alanine namespace: compound synonym: "C3H7NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16977 xref: KEGG:C00041 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00042 name: succinate namespace: compound synonym: "C4H6O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)" RELATED InChI [UPa:] xref: CHEBI:15741 xref: KEGG:C00042 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00043 name: UDP-N-acetyl-alpha-D-glucosamine namespace: compound synonym: "C17H27N3O17P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1" RELATED InChI [UPa:] synonym: "UDP-N-acetyl-D-glucosamine" EXACT [KEGG:KEGG] xref: CHEBI:16264 xref: KEGG:C00043 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00044 name: GTP namespace: compound synonym: "C10H16N5O14P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15996 xref: KEGG:C00044 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00047 name: L-lysine namespace: compound synonym: "C6H14N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18019 xref: KEGG:C00047 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00048 name: glyoxylate namespace: compound synonym: "C2H2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)" RELATED InChI [UPa:] xref: CHEBI:16891 xref: KEGG:C00048 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00049 name: L-aspartate namespace: compound synonym: "C4H7NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17053 xref: KEGG:C00049 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00051 name: glutathione namespace: compound synonym: "C10H17N3O6S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16856 xref: KEGG:C00051 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00053 name: 3'-phospho-5'-adenylyl sulfate namespace: compound synonym: "3'-phosphoadenylyl sulfate" EXACT [KEGG:KEGG] synonym: "C10H15N5O13P2S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/t4-,6-,7-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17980 xref: KEGG:C00053 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00054 name: adenosine 3',5'-bisphosphate namespace: compound synonym: "C10H15N5O10P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/t4-,6-,7-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17985 xref: KEGG:C00054 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00055 name: CMP namespace: compound synonym: "C9H14N3O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17361 xref: KEGG:C00055 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00058 name: formate namespace: compound synonym: "CH2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)" RELATED InChI [UPa:] xref: CHEBI:15740 xref: CHEBI:30751 xref: KEGG:C00058 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00059 name: sulfate namespace: compound synonym: "H2O4S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)" RELATED InChI [UPa:] xref: CHEBI:16189 xref: CHEBI:26836 xref: KEGG:C00059 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00061 name: FMN namespace: compound synonym: "C17H21N4O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C17H21N4O9P/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29)/t11-,12+,14-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17621 xref: KEGG:C00061 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00062 name: L-arginine namespace: compound synonym: "C6H14N4O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16467 xref: KEGG:C00062 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00063 name: CTP namespace: compound synonym: "C9H16N3O14P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17677 xref: KEGG:C00063 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00064 name: L-glutamine namespace: compound synonym: "C5H10N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18050 xref: KEGG:C00064 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00065 name: L-serine namespace: compound synonym: "C3H7NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17115 xref: KEGG:C00065 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00067 name: formaldehyde namespace: compound synonym: "CH2O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/CH2O/c1-2/h1H2" RELATED InChI [UPa:] xref: CHEBI:16842 xref: KEGG:C00067 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00068 name: thiamine diphosphate namespace: compound synonym: "C12H19N4O7P2S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21)/p+1" RELATED InChI [UPa:] synonym: "thiamine pyrophosphate" EXACT [KEGG:KEGG] synonym: "ThPP" EXACT [KEGG:KEGG] xref: CHEBI:9532 xref: KEGG:C00068 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00072 name: L-ascorbate namespace: compound synonym: "C6H8O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1" RELATED InChI [UPa:] synonym: "L-ascorbic acid" EXACT [KEGG:KEGG] xref: CHEBI:29073 xref: CHEBI:38290 xref: KEGG:C00072 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00073 name: L-methionine namespace: compound synonym: "C5H11NO2S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16643 xref: KEGG:C00073 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00074 name: phosphoenolpyruvate namespace: compound synonym: "C3H5O6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H5O6P/c1-2(3(4)5)9-10(6,7)8/h1H2,(H,4,5)(H2,6,7,8)" RELATED InChI [UPa:] synonym: "PEP" EXACT [KEGG:KEGG] xref: CHEBI:18021 xref: CHEBI:44897 xref: KEGG:C00074 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00075 name: UTP namespace: compound synonym: "C9H15N2O15P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15713 xref: KEGG:C00075 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00077 name: L-ornithine namespace: compound synonym: "C5H12N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15729 xref: KEGG:C00077 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00078 name: L-tryptophan namespace: compound synonym: "C11H12N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16828 xref: KEGG:C00078 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00079 name: L-phenylalanine namespace: compound synonym: "C9H11NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17295 xref: KEGG:C00079 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00080 name: H(+) namespace: compound synonym: "H" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/p+1" RELATED InChI [UPa:] xref: CHEBI:15378 xref: CHEBI:24636 xref: KEGG:C00080 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00082 name: L-tyrosine namespace: compound synonym: "C9H11NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17895 xref: KEGG:C00082 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00083 name: malonyl-CoA namespace: compound synonym: "C24H38N7O19P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/t12-,17-,18-,19+,23-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15531 xref: KEGG:C00083 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00084 name: acetaldehyde namespace: compound synonym: "C2H4O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H4O/c1-2-3/h2H,1H3" RELATED InChI [UPa:] xref: CHEBI:15343 xref: KEGG:C00084 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00085 name: D-fructose 6-phosphate namespace: compound synonym: "C6H13O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/t3-,4-,5+,6?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15946 xref: CHEBI:61553 xref: KEGG:C00085 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00086 name: urea namespace: compound synonym: "CH4N2O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)" RELATED InChI [UPa:] xref: CHEBI:16199 xref: KEGG:C00086 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00087 name: sulfur namespace: compound synonym: "H2S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/S" RELATED InChI [UPa:] xref: CHEBI:17909 xref: CHEBI:26833 xref: KEGG:C00087 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00088 name: nitrite namespace: compound synonym: "HNO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/HNO2/c2-1-3/h(H,2,3)" RELATED InChI [UPa:] xref: CHEBI:16301 xref: CHEBI:25567 xref: KEGG:C00088 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00089 name: sucrose namespace: compound synonym: "C12H22O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17992 xref: KEGG:C00089 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00090 name: catechol namespace: compound synonym: "C6H6O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H" RELATED InChI [UPa:] xref: CHEBI:18135 xref: KEGG:C00090 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00091 name: succinyl-CoA namespace: compound synonym: "C25H40N7O19P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C25H40N7O19P3S/c1-25(2,20(38)23(39)28-6-5-14(33)27-7-8-55-16(36)4-3-15(34)35)10-48-54(45,46)51-53(43,44)47-9-13-19(50-52(40,41)42)18(37)24(49-13)32-12-31-17-21(26)29-11-30-22(17)32/h11-13,18-20,24,37-38H,3-10H2,1-2H3,(H,27,33)(H,28,39)(H,34,35)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/t13-,18-,19-,20+,24-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15380 xref: KEGG:C00091 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00092 name: D-glucose 6-phosphate namespace: compound synonym: "C6H13O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5-,6?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:4170 xref: KEGG:C00092 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00093 name: sn-glycerol 3-phosphate namespace: compound synonym: "C3H9O6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H9O6P/c4-1-3(5)2-9-10(6,7)8/h3-5H,1-2H2,(H2,6,7,8)/t3-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15978 xref: KEGG:C00093 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00094 name: sulfite namespace: compound synonym: "H2O3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)" RELATED InChI [UPa:] xref: CHEBI:48854 xref: KEGG:C00094 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00095 name: D-fructose namespace: compound synonym: "C6H12O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5+,6?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15824 xref: CHEBI:37721 xref: KEGG:C00095 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00096 name: GDP-alpha-D-mannose namespace: compound synonym: "C16H25N5O16P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "GDP-D-mannose" EXACT [KEGG:KEGG] synonym: "InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15820 xref: KEGG:C00096 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00097 name: L-cysteine namespace: compound synonym: "C3H7NO2S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17561 xref: KEGG:C00097 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00099 name: beta-alanine namespace: compound synonym: "C3H7NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)" RELATED InChI [UPa:] xref: CHEBI:16958 xref: KEGG:C00099 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00100 name: propanoyl-CoA namespace: compound synonym: "C24H40N7O17P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C24H40N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,34-35H,4-10H2,1-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/t13-,17-,18-,19+,23-/m1/s1" RELATED InChI [UPa:] synonym: "propionyl-CoA" EXACT [KEGG:KEGG] xref: CHEBI:15539 xref: KEGG:C00100 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00101 name: 5,6,7,8-tetrahydrofolate namespace: compound synonym: "C19H23N7O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11-,12-/m0/s1" RELATED InChI [UPa:] synonym: "tetrahydrofolate" EXACT [KEGG:KEGG] synonym: "THF" EXACT [KEGG:KEGG] xref: CHEBI:15635 xref: CHEBI:20506 xref: KEGG:C00101 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00103 name: alpha-D-glucose 1-phosphate namespace: compound synonym: "C6H13O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5-,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:29042 xref: KEGG:C00103 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00105 name: UMP namespace: compound synonym: "C9H13N2O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16695 xref: KEGG:C00105 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00106 name: uracil namespace: compound synonym: "C4H4N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)" RELATED InChI [UPa:] xref: CHEBI:17568 xref: KEGG:C00106 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00108 name: anthranilate namespace: compound synonym: "C7H7NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:16567 xref: CHEBI:30754 xref: KEGG:C00108 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00109 name: 2-oxobutanoate namespace: compound synonym: "2-ketobutyrate" EXACT [KEGG:KEGG] synonym: "C4H6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)" RELATED InChI [UPa:] xref: CHEBI:16763 xref: CHEBI:30831 xref: KEGG:C00109 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00111 name: glycerone phosphate namespace: compound synonym: "C3H7O6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)" RELATED InChI [UPa:] xref: CHEBI:16108 xref: KEGG:C00111 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00112 name: CDP namespace: compound synonym: "C9H15N3O11P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17239 xref: KEGG:C00112 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00113 name: pyrroloquinoline quinone namespace: compound synonym: "C14H6N2O8" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H6N2O8/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18/h1-2,15H,(H,19,20)(H,21,22)(H,23,24)" RELATED InChI [UPa:] xref: CHEBI:18315 xref: KEGG:C00113 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00114 name: choline namespace: compound synonym: "C5H14NO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1" RELATED InChI [UPa:] xref: CHEBI:15354 xref: KEGG:C00114 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00116 name: glycerol namespace: compound synonym: "C3H8O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2" RELATED InChI [UPa:] xref: CHEBI:17754 xref: KEGG:C00116 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00117 name: D-ribose 5-phosphate namespace: compound synonym: "C5H11O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17797 xref: CHEBI:52742 xref: KEGG:C00117 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00118 name: D-glyceraldehyde 3-phosphate namespace: compound synonym: "C3H7O6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-GAP" EXACT [KEGG:KEGG] synonym: "InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h1,3,5H,2H2,(H2,6,7,8)/t3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:29052 xref: KEGG:C00118 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00119 name: 5-phospho-alpha-D-ribose 1-diphosphate namespace: compound synonym: "C5H13O14P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17111 xref: KEGG:C00119 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00120 name: biotin namespace: compound synonym: "C10H16N2O3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15956 xref: KEGG:C00120 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00121 name: D-ribose namespace: compound synonym: "C5H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10O5/c6-1-2-3(7)4(8)5(9)10-2/h2-9H,1H2/t2-,3-,4-,5?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:47013 xref: KEGG:C00121 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00122 name: fumarate namespace: compound synonym: "C4H4O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+" RELATED InChI [UPa:] xref: CHEBI:18012 xref: CHEBI:29806 xref: KEGG:C00122 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00123 name: L-leucine namespace: compound synonym: "C6H13NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15603 xref: KEGG:C00123 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00125 name: ferricytochrome c namespace: compound xref: CHEBI:15991 xref: KEGG:C00125 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00126 name: ferrocytochrome c namespace: compound xref: CHEBI:16928 xref: KEGG:C00126 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00129 name: isopentenyl diphosphate namespace: compound synonym: "C5H12O7P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)" RELATED InChI [UPa:] synonym: "isopentenyl-PP" EXACT [KEGG:KEGG] xref: CHEBI:16584 xref: KEGG:C00129 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00130 name: IMP namespace: compound synonym: "C10H13N4O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17202 xref: KEGG:C00130 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00132 name: methanol namespace: compound synonym: "CH4O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/CH4O/c1-2/h2H,1H3" RELATED InChI [UPa:] xref: CHEBI:17790 xref: KEGG:C00132 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00133 name: D-alanine namespace: compound synonym: "C3H7NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15570 xref: KEGG:C00133 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00134 name: putrescine namespace: compound synonym: "C4H12N2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2" RELATED InChI [UPa:] xref: CHEBI:17148 xref: KEGG:C00134 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00135 name: L-histidine namespace: compound synonym: "C6H9N3O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15971 xref: KEGG:C00135 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00137 name: myo-inositol namespace: compound synonym: "C6H12O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6-" RELATED InChI [UPa:] xref: CHEBI:17268 xref: KEGG:C00137 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00138 name: reduced ferredoxin namespace: compound xref: CHEBI:17513 xref: KEGG:C00138 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00139 name: oxidized ferredoxin namespace: compound xref: CHEBI:17908 xref: KEGG:C00139 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00140 name: N-acetyl-D-glucosamine namespace: compound synonym: "C8H15NO6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:506227 xref: KEGG:C00140 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00141 name: 3-methyl-2-oxobutanoate namespace: compound synonym: "C5H8O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)" RELATED InChI [UPa:] xref: CHEBI:11851 xref: CHEBI:16530 xref: KEGG:C00141 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00143 name: 5,10-methylene-THF namespace: compound synonym: "C20H23N7O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12-,13?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:1989 xref: KEGG:C00143 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00144 name: GMP namespace: compound synonym: "C10H14N5O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17345 xref: KEGG:C00144 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00147 name: adenine namespace: compound synonym: "C5H5N5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)" RELATED InChI [UPa:] xref: CHEBI:16708 xref: KEGG:C00147 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00148 name: L-proline namespace: compound synonym: "C5H9NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17203 xref: KEGG:C00148 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00149 name: (S)-malate namespace: compound synonym: "C4H6O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m0/s1" RELATED InChI [UPa:] synonym: "L-malate" EXACT [KEGG:KEGG] xref: CHEBI:15589 xref: CHEBI:30797 xref: KEGG:C00149 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00152 name: L-asparagine namespace: compound synonym: "C4H8N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17196 xref: KEGG:C00152 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00153 name: nicotinamide namespace: compound synonym: "C6H6N2O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)" RELATED InChI [UPa:] xref: CHEBI:17154 xref: KEGG:C00153 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00155 name: L-homocysteine namespace: compound synonym: "C4H9NO2S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17588 xref: KEGG:C00155 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00156 name: 4-hydroxybenzoate namespace: compound synonym: "C7H6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:17879 xref: CHEBI:30763 xref: KEGG:C00156 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00157 name: phosphatidylcholine namespace: compound xref: CHEBI:16110 xref: CHEBI:49183 xref: KEGG:C00157 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00158 name: citrate namespace: compound synonym: "C6H8O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "citric acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)" RELATED InChI [UPa:] xref: CHEBI:16947 xref: CHEBI:30769 xref: KEGG:C00158 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00160 name: glycolate namespace: compound synonym: "C2H4O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "glycolic acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)" RELATED InChI [UPa:] xref: CHEBI:17497 xref: CHEBI:29805 xref: KEGG:C00160 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00162 name: fatty acid namespace: compound xref: CHEBI:35366 xref: KEGG:C00162 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00163 name: propanoate namespace: compound synonym: "C3H6O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)" RELATED InChI [UPa:] xref: CHEBI:17272 xref: CHEBI:30768 xref: KEGG:C00163 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00164 name: acetoacetate namespace: compound synonym: "acetoacetic acid" EXACT [KEGG:KEGG] synonym: "C4H6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)" RELATED InChI [UPa:] xref: CHEBI:13705 xref: CHEBI:15344 xref: KEGG:C00164 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00165 name: diacylglycerol namespace: compound xref: CHEBI:18035 xref: KEGG:C00165 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00166 name: phenylpyruvate namespace: compound synonym: "C9H8O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H8O3/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,11,12)" RELATED InChI [UPa:] xref: CHEBI:18005 xref: CHEBI:30851 xref: KEGG:C00166 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00167 name: UDP-alpha-D-glucuronate namespace: compound synonym: "C15H22N2O18P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H22N2O18P2/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26)/t4-,6-,7+,8+,9-,10-,11+,12-,14-/m1/s1" RELATED InChI [UPa:] synonym: "UDP-glucuronic acid" EXACT [KEGG:KEGG] xref: CHEBI:17200 xref: KEGG:C00167 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00168 name: 3-hydroxypyruvate namespace: compound synonym: "3-hydroxypyruvic acid" EXACT [KEGG:KEGG] synonym: "C3H4O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)" RELATED InChI [UPa:] xref: CHEBI:17180 xref: CHEBI:30841 xref: KEGG:C00168 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00169 name: carbamoyl phosphate namespace: compound synonym: "CH4NO5P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/CH4NO5P/c2-1(3)7-8(4,5)6/h(H2,2,3)(H2,4,5,6)" RELATED InChI [UPa:] xref: CHEBI:17672 xref: KEGG:C00169 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00170 name: S-methyl-5'-thioadenosine namespace: compound synonym: "(S)-methyl-5'-thioadenosine" EXACT [KEGG:KEGG] synonym: "C11H15N5O3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17509 xref: KEGG:C00170 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00175 name: Co(2+) namespace: compound synonym: "Co" RELATED FORMULA [KEGG:COMPOUND] synonym: "cobalt" EXACT [KEGG:KEGG] synonym: "InChI=1S/Co/q+2" RELATED InChI [UPa:] xref: CHEBI:27638 xref: CHEBI:48828 xref: KEGG:C00175 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00177 name: hydrogen cyanide namespace: compound synonym: "CN" RELATED FORMULA [KEGG:COMPOUND] synonym: "cyanide" EXACT [KEGG:KEGG] synonym: "InChI=1S/CN/c1-2/q-1" RELATED InChI [UPa:] xref: CHEBI:17514 xref: KEGG:C00177 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00178 name: thymine namespace: compound synonym: "C5H6N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)" RELATED InChI [UPa:] xref: CHEBI:17821 xref: KEGG:C00178 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00179 name: agmatine namespace: compound synonym: "C5H14N4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H14N4/c6-3-1-2-4-9-5(7)8/h1-4,6H2,(H4,7,8,9)" RELATED InChI [UPa:] xref: CHEBI:17431 xref: KEGG:C00179 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00180 name: benzoate namespace: compound synonym: "benzoic acid" EXACT [KEGG:KEGG] synonym: "C7H6O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)" RELATED InChI [UPa:] xref: CHEBI:16150 xref: CHEBI:30746 xref: KEGG:C00180 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00182 name: glycogen namespace: compound synonym: "C24H42O21" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C24H42O21/c25-1-5-9(28)11(30)16(35)22(41-5)39-4-8-20(45-23-17(36)12(31)10(29)6(2-26)42-23)14(33)18(37)24(43-8)44-19-7(3-27)40-21(38)15(34)13(19)32/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10-,11+,12+,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28087 xref: KEGG:C00182 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00183 name: L-valine namespace: compound synonym: "C5H11NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16414 xref: KEGG:C00183 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00184 name: glycerone namespace: compound synonym: "C3H6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2" RELATED InChI [UPa:] xref: CHEBI:16016 xref: KEGG:C00184 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00186 name: (S)-lactate namespace: compound synonym: "C3H6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16651 xref: CHEBI:422 xref: KEGG:C00186 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00187 name: cholesterol namespace: compound synonym: "C27H46O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16113 xref: KEGG:C00187 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00188 name: L-threonine namespace: compound synonym: "C4H9NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16857 xref: KEGG:C00188 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00189 name: ethanolamine namespace: compound synonym: "C2H7NO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2" RELATED InChI [UPa:] xref: CHEBI:16000 xref: KEGG:C00189 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00190 name: UDP-alpha-D-xylose namespace: compound synonym: "C14H22N2O16P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H22N2O16P2/c17-5-3-28-13(11(22)8(5)19)31-34(26,27)32-33(24,25)29-4-6-9(20)10(21)12(30-6)16-2-1-7(18)15-14(16)23/h1-2,5-6,8-13,17,19-22H,3-4H2,(H,24,25)(H,26,27)(H,15,18,23)/t5-,6-,8+,9-,10-,11-,12?,13-/m1/s1" RELATED InChI [UPa:] synonym: "UDP-D-xylose" EXACT [KEGG:KEGG] xref: CHEBI:16082 xref: KEGG:C00190 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00191 name: D-glucuronate namespace: compound synonym: "C6H10O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-glucuronic acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6?/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15748 xref: CHEBI:4178 xref: CHEBI:47952 xref: KEGG:C00191 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00194 name: adenosylcobalamin namespace: compound synonym: "C72H100CoN18O17P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56?,57+,59-,60+,61+,62+;4-,6-,7-,10-;/m11./s1" RELATED InChI [UPa:] xref: CHEBI:18408 xref: KEGG:C00194 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00197 name: 3-phospho-D-glycerate namespace: compound synonym: "3-phospho-D-glyceric acid" EXACT [KEGG:KEGG] synonym: "C3H7O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17794 xref: KEGG:C00197 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00198 name: D-glucono-1,5-lactone namespace: compound synonym: "C6H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-5,7-10H,1H2/t2-,3-,4+,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16217 xref: KEGG:C00198 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00199 name: D-ribulose 5-phosphate namespace: compound synonym: "C5H11O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/t4-,5+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17363 xref: KEGG:C00199 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00204 name: 2-dehydro-3-deoxy-D-gluconate namespace: compound synonym: "2-dehydro-3-deoxy-D-gluconic acid" EXACT [KEGG:KEGG] synonym: "C6H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O6/c7-2-5(10)3(8)1-4(9)6(11)12/h3,5,7-8,10H,1-2H2,(H,11,12)/t3-,5+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17032 xref: KEGG:C00204 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00208 name: maltose namespace: compound synonym: "C12H22O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5-,6+,7-,8-,9-,10-,11?,12-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17306 xref: KEGG:C00208 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00209 name: oxalate namespace: compound synonym: "C2H2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)" RELATED InChI [UPa:] xref: CHEBI:16995 xref: CHEBI:30623 xref: KEGG:C00209 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00212 name: adenosine namespace: compound synonym: "C10H13N5O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16335 xref: KEGG:C00212 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00213 name: sarcosine namespace: compound synonym: "C3H7NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)" RELATED InChI [UPa:] xref: CHEBI:15611 xref: KEGG:C00213 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00214 name: thymidine namespace: compound synonym: "C10H14N2O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17748 xref: KEGG:C00214 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00216 name: D-arabinose namespace: compound synonym: "C5H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10O5/c6-2-1-10-5(9)4(8)3(2)7/h2-9H,1H2/t2-,3-,4+,5?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17108 xref: CHEBI:46994 xref: KEGG:C00216 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00218 name: methylamine namespace: compound synonym: "CH5N" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/CH5N/c1-2/h2H2,1H3" RELATED InChI [UPa:] xref: CHEBI:16830 xref: KEGG:C00218 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00219 name: arachidonate namespace: compound synonym: "C20H32O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-15-" RELATED InChI [UPa:] xref: CHEBI:15843 xref: KEGG:C00219 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00221 name: beta-D-glucose namespace: compound synonym: "C6H12O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15903 xref: KEGG:C00221 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00222 name: 3-oxopropanoate namespace: compound synonym: "C3H4O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)" RELATED InChI [UPa:] xref: CHEBI:17960 xref: CHEBI:33190 xref: KEGG:C00222 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00223 name: 4-coumaroyl-CoA namespace: compound synonym: "C30H42N7O18P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/b8-5+/t19-,23-,24-,25+,29-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15499 xref: KEGG:C00223 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00224 name: 5'-adenylyl sulfate namespace: compound synonym: "adenylyl sulfate" EXACT [KEGG:KEGG] synonym: "C10H14N5O10PS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/t4-,6-,7-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17709 xref: KEGG:C00224 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00227 name: acetyl phosphate namespace: compound synonym: "C2H5O5P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H5O5P/c1-2(3)7-8(4,5)6/h1H3,(H2,4,5,6)" RELATED InChI [UPa:] xref: CHEBI:15350 xref: KEGG:C00227 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00229 name: acyl-carrier protein namespace: compound xref: CHEBI:18359 xref: KEGG:C00229 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00230 name: 3,4-dihydroxybenzoate namespace: compound synonym: "C7H6O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)" RELATED InChI [UPa:] xref: CHEBI:36062 xref: CHEBI:36241 xref: KEGG:C00230 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00231 name: D-xylulose 5-phosphate namespace: compound synonym: "C5H11O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/t4-,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16332 xref: KEGG:C00231 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00232 name: succinate semialdehyde namespace: compound synonym: "C4H6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H6O3/c5-3-1-2-4(6)7/h3H,1-2H2,(H,6,7)" RELATED InChI [UPa:] xref: CHEBI:16265 xref: KEGG:C00232 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00233 name: 4-methyl-2-oxopentanoate namespace: compound synonym: "4-methyl-2-oxopentanoic acid" EXACT [KEGG:KEGG] synonym: "C6H10O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)" RELATED InChI [UPa:] xref: CHEBI:17865 xref: CHEBI:48430 xref: KEGG:C00233 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00234 name: 10-formyl-5,6,7,8-tetrahydrofolate namespace: compound synonym: "10-formyltetrahydrofolate" EXACT [KEGG:KEGG] synonym: "C20H23N7O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t11-,13+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15637 xref: KEGG:C00234 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00235 name: dimethylallyl diphosphate namespace: compound synonym: "C5H12O7P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "dimethylallyl-PP" EXACT [KEGG:KEGG] synonym: "InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)" RELATED InChI [UPa:] xref: CHEBI:16057 xref: KEGG:C00235 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00236 name: 3-phospho-D-glyceroyl phosphate namespace: compound synonym: "C3H8O10P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16001 xref: KEGG:C00236 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00237 name: CO namespace: compound synonym: "carbon monoxide" EXACT [KEGG:KEGG] synonym: "CH2O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/CO/c1-2" RELATED InChI [UPa:] xref: CHEBI:17245 xref: KEGG:C00237 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00242 name: guanine namespace: compound synonym: "C5H5N5O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)" RELATED InChI [UPa:] xref: CHEBI:16235 xref: KEGG:C00242 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00243 name: lactose namespace: compound synonym: "C12H22O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-lactose" EXACT [KEGG:KEGG] synonym: "InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17716 xref: CHEBI:36219 xref: KEGG:C00243 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00244 name: nitrate namespace: compound synonym: "HNO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/HNO3/c2-1(3)4/h(H,2,3,4)" RELATED InChI [UPa:] xref: CHEBI:48107 xref: CHEBI:51081 xref: KEGG:C00244 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00245 name: taurine namespace: compound synonym: "C2H7NO3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)" RELATED InChI [UPa:] xref: CHEBI:15891 xref: KEGG:C00245 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00246 name: butanoate namespace: compound synonym: "C4H8O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)" RELATED InChI [UPa:] xref: CHEBI:17968 xref: CHEBI:30772 xref: KEGG:C00246 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00247 name: L-sorbose namespace: compound synonym: "C6H12O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O6/c7-2-6(11)5(10)4(9)3(8)1-12-6/h3-5,7-11H,1-2H2/t3-,4+,5-,6?/m0/s1" RELATED InChI [UPa:] xref: CHEBI:48649 xref: KEGG:C00247 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00248 name: lipoamide namespace: compound synonym: "C8H15NOS2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10)" RELATED InChI [UPa:] xref: CHEBI:17460 xref: KEGG:C00248 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00250 name: pyridoxal namespace: compound synonym: "C8H9NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H9NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,4,10,12H,3H2,1H3" RELATED InChI [UPa:] xref: CHEBI:17310 xref: KEGG:C00250 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00251 name: chorismate namespace: compound synonym: "C10H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H10O6/c1-5(9(12)13)16-8-4-6(10(14)15)2-3-7(8)11/h2-4,7-8,11H,1H2,(H,12,13)(H,14,15)/t7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17333 xref: KEGG:C00251 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00253 name: nicotinate namespace: compound synonym: "C6H5NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)" RELATED InChI [UPa:] xref: CHEBI:15940 xref: KEGG:C00253 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00254 name: prephenate namespace: compound synonym: "C10H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H10O6/c11-6-1-3-10(4-2-6,9(15)16)5-7(12)8(13)14/h1-4,6,11H,5H2,(H,13,14)(H,15,16)/t6-,10+" RELATED InChI [UPa:] xref: CHEBI:29934 xref: CHEBI:84387 xref: KEGG:C00254 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00255 name: riboflavin namespace: compound synonym: "C17H20N4O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17015 xref: KEGG:C00255 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00256 name: (R)-lactate namespace: compound synonym: "C3H6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-lactate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16004 xref: CHEBI:42111 xref: KEGG:C00256 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00257 name: D-gluconate namespace: compound synonym: "C6H12O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-gluconic acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3-,4+,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18391 xref: CHEBI:33198 xref: KEGG:C00257 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00258 name: D-glycerate namespace: compound synonym: "C3H6O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-glyceric acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/t2-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16659 xref: CHEBI:32398 xref: KEGG:C00258 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00259 name: L-arabinose namespace: compound synonym: "C5H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10O5/c6-2-1-10-5(9)4(8)3(2)7/h2-9H,1H2/t2-,3-,4+,5?/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17535 xref: KEGG:C00259 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00261 name: benzaldehyde namespace: compound synonym: "C7H6O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H6O/c8-6-7-4-2-1-3-5-7/h1-6H" RELATED InChI [UPa:] xref: CHEBI:17169 xref: KEGG:C00261 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00262 name: hypoxanthine namespace: compound synonym: "C5H4N4O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)" RELATED InChI [UPa:] xref: CHEBI:17368 xref: KEGG:C00262 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00263 name: L-homoserine namespace: compound synonym: "C4H9NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15699 xref: KEGG:C00263 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00266 name: glycolaldehyde namespace: compound synonym: "C2H4O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2" RELATED InChI [UPa:] xref: CHEBI:17071 xref: KEGG:C00266 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00268 name: dihydrobiopterin namespace: compound synonym: "C9H13N5O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/t3-,4+,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:20680 xref: KEGG:C00268 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00269 name: CDP-diacylglycerol namespace: compound xref: CHEBI:17962 xref: KEGG:C00269 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00270 name: N-acetylneuraminate namespace: compound synonym: "C11H19NO9" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11?/m0/s1" RELATED InChI [UPa:] synonym: "N-acetylneuraminic acid" EXACT [KEGG:KEGG] xref: CHEBI:17012 xref: KEGG:C00270 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00272 name: tetrahydrobiopterin namespace: compound synonym: "C9H15N5O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,4+,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15372 xref: CHEBI:59560 xref: KEGG:C00272 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00275 name: D-mannose 6-phosphate namespace: compound synonym: "C6H13O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17369 xref: CHEBI:48066 xref: KEGG:C00275 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00279 name: D-erythrose 4-phosphate namespace: compound synonym: "C4H9O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H9O7P/c5-1-3(6)4(7)2-11-12(8,9)10/h1,3-4,6-7H,2H2,(H2,8,9,10)/t3-,4+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:48153 xref: KEGG:C00279 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00282 name: H(2) namespace: compound synonym: "dihydrogen" EXACT [KEGG:KEGG] synonym: "H2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/H2/h1H" RELATED InChI [UPa:] xref: CHEBI:18276 xref: KEGG:C00282 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00283 name: hydrogen sulfide namespace: compound synonym: "H(2)S" EXACT [KEGG:KEGG] synonym: "H2S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/H2S/h1H2" RELATED InChI [UPa:] xref: CHEBI:16136 xref: KEGG:C00283 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00288 name: bicarbonate namespace: compound synonym: "CHO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "HCO(3)(-)" EXACT [KEGG:KEGG] synonym: "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1" RELATED InChI [UPa:] xref: CHEBI:17544 xref: KEGG:C00288 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00294 name: inosine namespace: compound synonym: "C10H12N4O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17596 xref: KEGG:C00294 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00295 name: orotate namespace: compound synonym: "C5H4N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)" RELATED InChI [UPa:] xref: CHEBI:16742 xref: KEGG:C00295 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00296 name: D-quinate namespace: compound synonym: "C7H12O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H12O6/c8-3-1-7(13,6(11)12)2-4(9)5(3)10/h3-5,8-10,13H,1-2H2,(H,11,12)/t3-,4-,5-,7+/m1/s1" RELATED InChI [UPa:] synonym: "quinate" EXACT [KEGG:KEGG] xref: CHEBI:17521 xref: CHEBI:29751 xref: KEGG:C00296 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00299 name: uridine namespace: compound synonym: "C9H12N2O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16704 xref: KEGG:C00299 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00300 name: creatine namespace: compound synonym: "C4H9N3O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)" RELATED InChI [UPa:] xref: CHEBI:16919 xref: KEGG:C00300 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00307 name: CDP-choline namespace: compound synonym: "C14H26N4O11P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16436 xref: KEGG:C00307 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00310 name: D-xylulose namespace: compound synonym: "C5H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10O5/c6-2-5(9)4(8)3(7)1-10-5/h3-4,6-9H,1-2H2/t3-,4+,5?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17140 xref: KEGG:C00310 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00311 name: isocitrate namespace: compound synonym: "C6H8O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)" RELATED InChI [UPa:] xref: CHEBI:16087 xref: CHEBI:30887 xref: KEGG:C00311 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00312 name: L-xylulose namespace: compound synonym: "C5H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10O5/c6-2-5(9)4(8)3(7)1-10-5/h3-4,6-9H,1-2H2/t3-,4+,5?/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17399 xref: KEGG:C00312 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00313 name: oxalyl-CoA namespace: compound synonym: "C23H36N7O19P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C23H36N7O19P3S/c1-23(2,16(33)19(34)26-4-3-12(31)25-5-6-53-22(37)21(35)36)8-46-52(43,44)49-51(41,42)45-7-11-15(48-50(38,39)40)14(32)20(47-11)30-10-29-13-17(24)27-9-28-18(13)30/h9-11,14-16,20,32-33H,3-8H2,1-2H3,(H,25,31)(H,26,34)(H,35,36)(H,41,42)(H,43,44)(H2,24,27,28)(H2,38,39,40)/t11-,14-,15-,16+,20-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15535 xref: KEGG:C00313 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00314 name: pyridoxine namespace: compound synonym: "C8H11NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3" RELATED InChI [UPa:] xref: CHEBI:16709 xref: KEGG:C00314 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00315 name: spermidine namespace: compound synonym: "C7H19N3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2" RELATED InChI [UPa:] xref: CHEBI:16610 xref: KEGG:C00315 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00322 name: 2-oxoadipate namespace: compound synonym: "C6H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)" RELATED InChI [UPa:] xref: CHEBI:15753 xref: KEGG:C00322 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00325 name: GDP-L-fucose namespace: compound synonym: "C16H25N5O15P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/t4-,5+,7+,8+,9+,10+,11-,14+,15+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:13332 xref: CHEBI:17009 xref: KEGG:C00325 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00327 name: L-citrulline namespace: compound synonym: "C6H13N3O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16349 xref: KEGG:C00327 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00328 name: L-kynurenine namespace: compound synonym: "C10H12N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16946 xref: KEGG:C00328 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00332 name: acetoacetyl-CoA namespace: compound synonym: "C25H40N7O18P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t14-,18-,19-,20+,24-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15345 xref: KEGG:C00332 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00333 name: D-galacturonate namespace: compound synonym: "C6H10O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2+,3+,4-,6?/m0/s1" RELATED InChI [UPa:] xref: CHEBI:12952 xref: CHEBI:4153 xref: KEGG:C00333 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00334 name: 4-aminobutanoate namespace: compound synonym: "C4H9NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)" RELATED InChI [UPa:] xref: CHEBI:16865 xref: CHEBI:30566 xref: KEGG:C00334 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00337 name: (S)-dihydroorotate namespace: compound synonym: "C5H6N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17025 xref: KEGG:C00337 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00341 name: geranyl diphosphate namespace: compound synonym: "C10H20O7P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "geranyl-PP" EXACT [KEGG:KEGG] synonym: "InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/b10-7+" RELATED InChI [UPa:] xref: CHEBI:17211 xref: KEGG:C00341 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00342 name: thioredoxin namespace: compound xref: CHEBI:15033 xref: CHEBI:15967 xref: KEGG:C00342 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00343 name: thioredoxin disulfide namespace: compound xref: CHEBI:18191 xref: KEGG:C00343 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00344 name: phosphatidylglycerol namespace: compound xref: CHEBI:17517 xref: KEGG:C00344 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00345 name: 6-phospho-D-gluconate namespace: compound synonym: "C6H13O10P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/t2-,3-,4+,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:48928 xref: KEGG:C00345 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00346 name: phosphoethanolamine namespace: compound synonym: "C2H8NO4P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)" RELATED InChI [UPa:] xref: CHEBI:17553 xref: KEGG:C00346 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00348 name: undecaprenyl phosphate namespace: compound synonym: "C55H91O4P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C55H91O4P/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)41-22-42-55(12)43-44-59-60(56,57)58/h23,25,27,29,31,33,35,37,39,41,43H,13-22,24,26,28,30,32,34,36,38,40,42,44H2,1-12H3,(H2,56,57,58)/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-41+,55-43+" RELATED InChI [UPa:] xref: CHEBI:16141 xref: CHEBI:27193 xref: KEGG:C00348 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00350 name: phosphatidylethanolamine namespace: compound xref: CHEBI:16038 xref: KEGG:C00350 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00352 name: alpha-D-glucosamine 6-phosphate namespace: compound synonym: "C6H14NO8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-glucosamine 6-phosphate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H14NO8P/c7-3-5(9)4(8)2(15-6(3)10)1-14-16(11,12)13/h2-6,8-10H,1,7H2,(H2,11,12,13)/t2-,3-,4-,5-,6?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15873 xref: CHEBI:47987 xref: KEGG:C00352 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00353 name: geranylgeranyl diphosphate namespace: compound synonym: "C20H36O7P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "geranylgeranyl-PP" EXACT [KEGG:KEGG] synonym: "InChI=1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+" RELATED InChI [UPa:] xref: CHEBI:48861 xref: KEGG:C00353 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00354 name: D-fructose 1,6-bisphosphate namespace: compound synonym: "C6H14O12P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/t3-,4-,5+,6?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16905 xref: CHEBI:37736 xref: KEGG:C00354 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00355 name: L-dopa namespace: compound synonym: "3,4-dihydroxy-L-phenylalanine" EXACT [KEGG:KEGG] synonym: "C9H11NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15765 xref: KEGG:C00355 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00356 name: (S)-3-hydroxy-3-methylglutaryl-CoA namespace: compound synonym: "C27H44N7O20P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "HMG-CoA" EXACT [KEGG:KEGG] synonym: "InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15467 xref: KEGG:C00356 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00357 name: N-acetyl-D-glucosamine 6-phosphate namespace: compound synonym: "C8H16NO9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15784 xref: KEGG:C00357 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00364 name: dTMP namespace: compound synonym: "C10H15N2O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17013 xref: KEGG:C00364 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00365 name: dUMP namespace: compound synonym: "C9H13N2O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17622 xref: KEGG:C00365 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00366 name: urate namespace: compound synonym: "C5H4N4O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)" RELATED InChI [UPa:] synonym: "uric acid" EXACT [KEGG:KEGG] xref: CHEBI:17775 xref: KEGG:C00366 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00369 name: starch namespace: compound xref: CHEBI:28017 xref: KEGG:C00369 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00378 name: thiamine namespace: compound synonym: "C12H17N4OS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1" RELATED InChI [UPa:] xref: CHEBI:18385 xref: KEGG:C00378 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00379 name: xylitol namespace: compound synonym: "C5H12O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+" RELATED InChI [UPa:] xref: CHEBI:17151 xref: KEGG:C00379 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00380 name: cytosine namespace: compound synonym: "C4H5N3O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)" RELATED InChI [UPa:] xref: CHEBI:16040 xref: KEGG:C00380 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00383 name: malonate namespace: compound synonym: "C3H4O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)" RELATED InChI [UPa:] xref: CHEBI:15792 xref: CHEBI:30794 xref: KEGG:C00383 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00385 name: xanthine namespace: compound synonym: "C5H4N4O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11)" RELATED InChI [UPa:] xref: CHEBI:17712 xref: CHEBI:48517 xref: KEGG:C00385 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00388 name: histamine namespace: compound synonym: "C5H9N3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)" RELATED InChI [UPa:] xref: CHEBI:18295 xref: KEGG:C00388 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00390 name: ubiquinol namespace: compound synonym: "C19H28O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C19H28O4/c1-12(2)8-7-9-13(3)10-11-15-14(4)16(20)18(22-5)19(23-6)17(15)21/h8,10,20-21H,7,9,11H2,1-6H3/b13-10+" RELATED InChI [UPa:] xref: CHEBI:17976 xref: KEGG:C00390 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00395 name: penicillin namespace: compound xref: CHEBI:17334 xref: KEGG:C00395 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00398 name: tryptamine namespace: compound synonym: "C10H12N2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2" RELATED InChI [UPa:] xref: CHEBI:16765 xref: KEGG:C00398 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00399 name: ubiquinone namespace: compound synonym: "C19H26O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C19H26O4/c1-12(2)8-7-9-13(3)10-11-15-14(4)16(20)18(22-5)19(23-6)17(15)21/h8,10H,7,9,11H2,1-6H3/b13-10+" RELATED InChI [UPa:] xref: CHEBI:16389 xref: KEGG:C00399 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00407 name: L-isoleucine namespace: compound synonym: "C6H13NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17191 xref: KEGG:C00407 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00413 name: streptomycin namespace: compound synonym: "C21H39N7O12" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17076 xref: KEGG:C00413 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00415 name: 7,8-dihydrofolate namespace: compound synonym: "C19H21N7O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "dihydrofolate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15633 xref: KEGG:C00415 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00416 name: phosphatidate namespace: compound xref: CHEBI:16337 xref: KEGG:C00416 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00417 name: cis-aconitate namespace: compound synonym: "C6H6O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "cis-aconitic acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/b3-1-" RELATED InChI [UPa:] xref: CHEBI:16383 xref: CHEBI:32805 xref: KEGG:C00417 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00418 name: (R)-mevalonate namespace: compound synonym: "(R)-mevalonic acid" EXACT [KEGG:KEGG] synonym: "C6H12O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/t6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17710 xref: CHEBI:36464 xref: KEGG:C00418 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00423 name: trans-cinnamate namespace: compound synonym: "C9H8O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H8O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-7H,(H,10,11)/b7-6+" RELATED InChI [UPa:] synonym: "trans-cinnamic acid" EXACT [KEGG:KEGG] xref: CHEBI:15669 xref: CHEBI:35697 xref: KEGG:C00423 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00424 name: L-lactaldehyde namespace: compound synonym: "C3H6O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18041 xref: KEGG:C00424 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00430 name: 5-aminolevulinate namespace: compound synonym: "C5H9NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)" RELATED InChI [UPa:] xref: CHEBI:17549 xref: KEGG:C00430 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00431 name: 5-aminopentanoate namespace: compound synonym: "C5H11NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11NO2/c6-4-2-1-3-5(7)8/h1-4,6H2,(H,7,8)" RELATED InChI [UPa:] xref: CHEBI:15887 xref: KEGG:C00431 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00433 name: 2,5-dioxopentanoate namespace: compound synonym: "2,5-dioxopentanoic acid" EXACT [KEGG:KEGG] synonym: "C5H6O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H6O4/c6-3-1-2-4(7)5(8)9/h3H,1-2H2,(H,8,9)" RELATED InChI [UPa:] xref: CHEBI:17415 xref: KEGG:C00433 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00436 name: N-carbamoylputrescine namespace: compound synonym: "C5H13N3O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H13N3O/c6-3-1-2-4-8-5(7)9/h1-4,6H2,(H3,7,8,9)" RELATED InChI [UPa:] xref: CHEBI:17902 xref: KEGG:C00436 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00437 name: N(2)-acetyl-L-ornithine namespace: compound synonym: "C7H14N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H14N2O3/c1-5(10)9-6(7(11)12)3-2-4-8/h6H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16543 xref: KEGG:C00437 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00438 name: N-carbamoyl-L-aspartate namespace: compound synonym: "C5H8N2O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8N2O5/c6-5(12)7-2(4(10)11)1-3(8)9/h2H,1H2,(H,8,9)(H,10,11)(H3,6,7,12)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15859 xref: KEGG:C00438 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00439 name: N-formimidoyl-L-glutamate namespace: compound synonym: "C6H10N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10N2O4/c7-3-8-4(6(11)12)1-2-5(9)10/h3-4H,1-2H2,(H2,7,8)(H,9,10)(H,11,12)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18327 xref: CHEBI:7274 xref: KEGG:C00439 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00440 name: 5-methyl-THF namespace: compound synonym: "5-methyltetrahydrofolate" EXACT [KEGG:KEGG] synonym: "C20H25N7O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C20H25N7O6/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31)/t12-,13-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15641 xref: CHEBI:20612 xref: KEGG:C00440 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00441 name: L-aspartate 4-semialdehyde namespace: compound synonym: "C4H7NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H7NO3/c5-3(1-2-6)4(7)8/h2-3H,1,5H2,(H,7,8)/t3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:13086 xref: CHEBI:18051 xref: KEGG:C00441 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00448 name: farnesyl diphosphate namespace: compound synonym: "C15H28O7P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "farnesyl-PP" EXACT [KEGG:KEGG] synonym: "InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+" RELATED InChI [UPa:] xref: CHEBI:17407 xref: KEGG:C00448 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00449 name: saccharopine namespace: compound synonym: "C11H20N2O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/t7-,8-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16927 xref: KEGG:C00449 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00455 name: nicotinamide D-ribonucleotide namespace: compound synonym: "C11H15N2O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1" RELATED InChI [UPa:] synonym: "nicotinamide ribonucleotide" EXACT [KEGG:KEGG] xref: CHEBI:16171 xref: KEGG:C00455 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00458 name: dCTP namespace: compound synonym: "C9H16N3O13P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H16N3O13P3/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16311 xref: KEGG:C00458 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00459 name: dTTP namespace: compound synonym: "C10H17N2O14P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18077 xref: KEGG:C00459 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00460 name: dUTP namespace: compound synonym: "C9H15N2O14P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17625 xref: KEGG:C00460 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00461 name: chitin namespace: compound xref: CHEBI:17029 xref: KEGG:C00461 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00463 name: indole namespace: compound synonym: "C8H7N" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H7N/c1-2-4-8-7(3-1)5-6-9-8/h1-6,9H" RELATED InChI [UPa:] xref: CHEBI:16881 xref: KEGG:C00463 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00466 name: acetoin namespace: compound synonym: "C4H8O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H8O2/c1-3(5)4(2)6/h3,5H,1-2H3" RELATED InChI [UPa:] xref: CHEBI:15688 xref: KEGG:C00466 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00469 name: ethanol namespace: compound synonym: "C2H6O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3" RELATED InChI [UPa:] xref: CHEBI:16236 xref: KEGG:C00469 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00470 name: pectate namespace: compound synonym: "C18H26O19" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C18H26O19/c19-1-2(20)10(13(26)27)36-17(6(1)24)35-9-4(22)7(25)18(37-12(9)15(30)31)34-8-3(21)5(23)16(32)33-11(8)14(28)29/h1-12,16-25,32H,(H,26,27)(H,28,29)(H,30,31)/t1-,2+,3+,4+,5+,6+,7+,8+,9+,10-,11-,12-,16?,17-,18-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15446 xref: CHEBI:17788 xref: CHEBI:68837 xref: KEGG:C00470 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00475 name: cytidine namespace: compound synonym: "C9H13N3O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17562 xref: KEGG:C00475 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00487 name: carnitine namespace: compound synonym: "C7H16NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/p+1" RELATED InChI [UPa:] xref: CHEBI:17126 xref: CHEBI:3424 xref: KEGG:C00487 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00488 name: formamide namespace: compound synonym: "CH3NO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/CH3NO/c2-1-3/h1H,(H2,2,3)" RELATED InChI [UPa:] xref: CHEBI:16397 xref: KEGG:C00488 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00489 name: glutarate namespace: compound synonym: "C5H8O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "glutaric acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9)" RELATED InChI [UPa:] xref: CHEBI:17859 xref: KEGG:C00489 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00492 name: raffinose namespace: compound synonym: "C18H32O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C18H32O16/c19-1-5-8(22)11(25)13(27)16(31-5)30-3-7-9(23)12(26)14(28)17(32-7)34-18(4-21)15(29)10(24)6(2-20)33-18/h5-17,19-29H,1-4H2/t5-,6-,7-,8+,9-,10-,11+,12+,13-,14-,15+,16+,17-,18+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16634 xref: KEGG:C00492 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00493 name: shikimate namespace: compound synonym: "C7H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H10O5/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1,4-6,8-10H,2H2,(H,11,12)/t4-,5-,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16119 xref: KEGG:C00493 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00499 name: allantoate namespace: compound synonym: "C4H8N4O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H8N4O4/c5-3(11)7-1(2(9)10)8-4(6)12/h1H,(H,9,10)(H3,5,7,11)(H3,6,8,12)" RELATED InChI [UPa:] xref: CHEBI:17536 xref: CHEBI:30837 xref: KEGG:C00499 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00501 name: CDP-glucose namespace: compound synonym: "C15H25N3O16P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H25N3O16P2/c16-7-1-2-18(15(25)17-7)13-11(23)9(21)6(31-13)4-30-35(26,27)34-36(28,29)33-14-12(24)10(22)8(20)5(3-19)32-14/h1-2,5-6,8-14,19-24H,3-4H2,(H,26,27)(H,28,29)(H2,16,17,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28942 xref: KEGG:C00501 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00504 name: folate namespace: compound synonym: "C19H19N7O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:27470 xref: KEGG:C00504 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00506 name: L-cysteate namespace: compound synonym: "C3H7NO5S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17285 xref: KEGG:C00506 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00507 name: L-rhamnose namespace: compound synonym: "C6H12O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3-,4+,5+,6?/m0/s1" RELATED InChI [UPa:] xref: CHEBI:62345 xref: CHEBI:62346 xref: KEGG:C00507 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00508 name: L-ribulose namespace: compound synonym: "C5H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10O5/c6-2-5(9)4(8)3(7)1-10-5/h3-4,6-9H,1-2H2/t3-,4-,5?/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16880 xref: KEGG:C00508 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00512 name: benzoyl-CoA namespace: compound synonym: "C28H40N7O17P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C28H40N7O17P3S/c1-28(2,22(38)25(39)31-9-8-18(36)30-10-11-56-27(40)16-6-4-3-5-7-16)13-49-55(46,47)52-54(44,45)48-12-17-21(51-53(41,42)43)20(37)26(50-17)35-15-34-19-23(29)32-14-33-24(19)35/h3-7,14-15,17,20-22,26,37-38H,8-13H2,1-2H3,(H,30,36)(H,31,39)(H,44,45)(H,46,47)(H2,29,32,33)(H2,41,42,43)/t17-,20-,21-,22+,26-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15515 xref: KEGG:C00512 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00519 name: hypotaurine namespace: compound synonym: "C2H7NO2S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)" RELATED InChI [UPa:] xref: CHEBI:16668 xref: KEGG:C00519 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00521 name: (4S)-limonene namespace: compound synonym: "C10H16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3/t10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15383 xref: KEGG:C00521 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00522 name: (R)-pantoate namespace: compound synonym: "C6H12O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O4/c1-6(2,3-7)4(8)5(9)10/h4,7-8H,3H2,1-2H3,(H,9,10)/t4-/m0/s1" RELATED InChI [UPa:] synonym: "pantoate" EXACT [KEGG:KEGG] xref: CHEBI:14737 xref: CHEBI:15980 xref: CHEBI:18697 xref: KEGG:C00522 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00524 name: cytochrome c namespace: compound xref: CHEBI:18070 xref: KEGG:C00524 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00527 name: glutaryl-CoA namespace: compound synonym: "C26H42N7O19P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/t14-,19-,20-,21+,25-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15524 xref: KEGG:C00527 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00532 name: L-arabinitol namespace: compound synonym: "C5H12O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18403 xref: KEGG:C00532 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00533 name: nitric oxide namespace: compound synonym: "InChI=1S/NO/c1-2" RELATED InChI [UPa:] synonym: "NO" RELATED FORMULA [KEGG:COMPOUND] xref: CHEBI:16480 xref: KEGG:C00533 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00534 name: pyridoxamine namespace: compound synonym: "C8H12N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H12N2O2/c1-5-8(12)7(2-9)6(4-11)3-10-5/h3,11-12H,2,4,9H2,1H3" RELATED InChI [UPa:] xref: CHEBI:16410 xref: KEGG:C00534 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00536 name: triphosphate namespace: compound synonym: "H5O10P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/H5O10P3/c1-11(2,3)9-13(7,8)10-12(4,5)6/h(H,7,8)(H2,1,2,3)(H2,4,5,6)" RELATED InChI [UPa:] xref: CHEBI:18036 xref: CHEBI:39949 xref: KEGG:C00536 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00544 name: homogentisate namespace: compound synonym: "C8H8O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "homogentisic acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)" RELATED InChI [UPa:] xref: CHEBI:16169 xref: CHEBI:44747 xref: KEGG:C00544 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00545 name: L-arabinonate namespace: compound synonym: "C5H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10O6/c6-1-2(7)3(8)4(9)5(10)11/h2-4,6-9H,1H2,(H,10,11)/t2-,3-,4+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16501 xref: CHEBI:33510 xref: KEGG:C00545 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00546 name: methylglyoxal namespace: compound synonym: "C3H4O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3" RELATED InChI [UPa:] xref: CHEBI:17158 xref: KEGG:C00546 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00547 name: (R)-noradrenaline namespace: compound synonym: "C8H11NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1" RELATED InChI [UPa:] synonym: "norepinephrine" EXACT [KEGG:KEGG] xref: CHEBI:18357 xref: KEGG:C00547 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00552 name: meso-tartrate namespace: compound synonym: "C4H6O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/t1-,2+" RELATED InChI [UPa:] synonym: "meso-tartaric acid" EXACT [KEGG:KEGG] xref: CHEBI:15673 xref: KEGG:C00552 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00555 name: 4-aminobutanal namespace: compound synonym: "C4H9NO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2" RELATED InChI [UPa:] xref: CHEBI:17769 xref: KEGG:C00555 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00557 name: cyclopentanone namespace: compound synonym: "C5H8O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O/c6-5-3-1-2-4-5/h1-4H2" RELATED InChI [UPa:] xref: CHEBI:16486 xref: KEGG:C00557 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00568 name: 4-aminobenzoate namespace: compound synonym: "C7H7NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H7NO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:17836 xref: CHEBI:30753 xref: KEGG:C00568 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00570 name: CDP-ethanolamine namespace: compound synonym: "C11H20N4O11P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/t6-,8-,9-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16732 xref: KEGG:C00570 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00575 name: 3',5'-cyclic AMP namespace: compound synonym: "C10H12N5O6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "cAMP" EXACT [KEGG:KEGG] synonym: "InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17489 xref: KEGG:C00575 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00576 name: betaine aldehyde namespace: compound synonym: "C5H12NO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1" RELATED InChI [UPa:] xref: CHEBI:15710 xref: KEGG:C00576 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00579 name: dihydrolipoamide namespace: compound synonym: "C8H17NOS2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10)" RELATED InChI [UPa:] xref: CHEBI:17694 xref: KEGG:C00579 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00581 name: guanidinoacetate namespace: compound synonym: "C3H7N3O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "guanidinoacetic acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6)" RELATED InChI [UPa:] xref: CHEBI:16344 xref: KEGG:C00581 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00582 name: phenylacetyl-CoA namespace: compound synonym: "C29H42N7O17P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/t18-,22-,23-,24+,28-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15537 xref: KEGG:C00582 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00588 name: phosphocholine namespace: compound synonym: "C5H15NO4P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p+1" RELATED InChI [UPa:] xref: CHEBI:18132 xref: KEGG:C00588 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00593 name: sulfoacetaldehyde namespace: compound synonym: "C2H4O4S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H4O4S/c3-1-2-7(4,5)6/h1H,2H2,(H,4,5,6)" RELATED InChI [UPa:] xref: CHEBI:17717 xref: KEGG:C00593 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00596 name: 2-hydroxy-2,4-pentadienoate namespace: compound synonym: "2-hydroxy-2,4-pentadienoic acid" EXACT [KEGG:KEGG] synonym: "C5H6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H6O3/c1-2-3-4(6)5(7)8/h2-3,6H,1H2,(H,7,8)/b4-3+" RELATED InChI [UPa:] xref: CHEBI:1113 xref: CHEBI:11641 xref: CHEBI:37319 xref: KEGG:C00596 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00597 name: 3-phosphoglycerate namespace: compound synonym: "C3H7O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)" RELATED InChI [UPa:] xref: CHEBI:17050 xref: KEGG:C00597 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00601 name: phenylacetaldehyde namespace: compound synonym: "C8H8O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2" RELATED InChI [UPa:] xref: CHEBI:16424 xref: KEGG:C00601 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00603 name: (S)-ureidoglycolate namespace: compound synonym: "C3H6N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H6N2O4/c4-3(9)5-1(6)2(7)8/h1,6H,(H,7,8)(H3,4,5,9)/t1-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15412 xref: KEGG:C00603 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00606 name: 3-sulfino-L-alanine namespace: compound synonym: "3-sulfinoalanine" EXACT [KEGG:KEGG] synonym: "C3H7NO4S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16345 xref: KEGG:C00606 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00615 name: protein-L-histidine namespace: compound xref: KEGG:C00615 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00620 name: alpha-D-ribose 1-phosphate namespace: compound synonym: "C5H11O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11O8P/c6-1-2-3(7)4(8)5(12-2)13-14(9,10)11/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16300 xref: KEGG:C00620 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00624 name: N-acetyl-L-glutamate namespace: compound synonym: "C7H11NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H11NO5/c1-4(9)8-5(7(12)13)2-3-6(10)11/h5H,2-3H2,1H3,(H,8,9)(H,10,11)(H,12,13)/t5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17533 xref: CHEBI:44337 xref: KEGG:C00624 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00627 name: pyridoxine 5'-phosphate namespace: compound synonym: "C8H12NO6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H12NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2,10-11H,3-4H2,1H3,(H2,12,13,14)" RELATED InChI [UPa:] xref: CHEBI:28803 xref: KEGG:C00627 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00631 name: 2-phospho-D-glycerate namespace: compound synonym: "C3H7O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17835 xref: KEGG:C00631 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00632 name: 3-hydroxyanthranilate namespace: compound synonym: "C7H7NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H7NO3/c8-6-4(7(10)11)2-1-3-5(6)9/h1-3,9H,8H2,(H,10,11)" RELATED InChI [UPa:] xref: CHEBI:15793 xref: CHEBI:36559 xref: KEGG:C00632 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00636 name: alpha-D-mannose 1-phosphate namespace: compound synonym: "C6H13O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18205 xref: CHEBI:35374 xref: KEGG:C00636 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00641 name: 1,2-diacyl-sn-glycerol namespace: compound xref: CHEBI:17815 xref: KEGG:C00641 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00642 name: 4-hydroxyphenylacetate namespace: compound synonym: "C8H8O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)" RELATED InChI [UPa:] xref: CHEBI:18101 xref: KEGG:C00642 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00643 name: 5-hydroxy-L-tryptophan namespace: compound synonym: "C11H12N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17780 xref: KEGG:C00643 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00645 name: N-acetyl-D-mannosamine namespace: compound synonym: "C8H15NO6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5+,6-,7-,8?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17122 xref: CHEBI:63153 xref: KEGG:C00645 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00647 name: pyridoxamine 5'-phosphate namespace: compound synonym: "C8H13N2O5P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H13N2O5P/c1-5-8(11)7(2-9)6(3-10-5)4-15-16(12,13)14/h3,11H,2,4,9H2,1H3,(H2,12,13,14)" RELATED InChI [UPa:] xref: CHEBI:18335 xref: KEGG:C00647 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00652 name: D-arabinono-1,4-lactone namespace: compound synonym: "C5H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O5/c6-1-2-3(7)4(8)5(9)10-2/h2-4,6-8H,1H2/t2-,3-,4+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16292 xref: KEGG:C00652 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00655 name: XMP namespace: compound synonym: "C10H13N4O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H13N4O9P/c15-5-3(1-22-24(19,20)21)23-9(6(5)16)14-2-11-4-7(14)12-10(18)13-8(4)17/h2-3,5-6,9,15-16H,1H2,(H2,19,20,21)(H2,12,13,17,18)/t3-,5-,6-,9-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15652 xref: KEGG:C00655 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00661 name: glyceraldehyde 3-phosphate namespace: compound synonym: "C3H7O6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h1,3,5H,2H2,(H2,6,7,8)" RELATED InChI [UPa:] xref: CHEBI:17138 xref: KEGG:C00661 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00664 name: 5-formiminotetrahydrofolate namespace: compound synonym: "C20H24N8O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C20H24N8O6/c21-9-28-12(8-24-16-15(28)18(32)27-20(22)26-16)7-23-11-3-1-10(2-4-11)17(31)25-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,21,23H,5-8H2,(H,25,31)(H,29,30)(H,33,34)(H4,22,24,26,27,32)/t12-,13-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15639 xref: KEGG:C00664 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00666 name: LL-2,6-diaminopimelate namespace: compound synonym: "C7H14N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H14N2O4/c8-4(6(10)11)2-1-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1" RELATED InChI [UPa:] synonym: "LL-diaminopimelate" EXACT [KEGG:KEGG] xref: CHEBI:16026 xref: CHEBI:47031 xref: KEGG:C00666 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00669 name: L-gamma-glutamyl-L-cysteine namespace: compound synonym: "C8H14N2O5S" RELATED FORMULA [KEGG:COMPOUND] synonym: "gamma-L-glutamyl-L-cysteine" EXACT [KEGG:KEGG] synonym: "InChI=1S/C8H14N2O5S/c9-4(7(12)13)1-2-6(11)10-5(3-16)8(14)15/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17515 xref: KEGG:C00669 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00671 name: (S)-3-methyl-2-oxopentanoate namespace: compound synonym: "(S)-3-methyl-2-oxopentanoic acid" EXACT [KEGG:KEGG] synonym: "C6H10O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15614 xref: CHEBI:35146 xref: KEGG:C00671 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00672 name: 2-deoxy-alpha-D-ribose 1-phosphate namespace: compound synonym: "2-deoxy-D-ribose 1-phosphate" EXACT [KEGG:KEGG] synonym: "C5H11O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11O7P/c6-2-4-3(7)1-5(11-4)12-13(8,9)10/h3-7H,1-2H2,(H2,8,9,10)/t3-,4+,5+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:11563 xref: CHEBI:28542 xref: KEGG:C00672 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00673 name: 2-deoxy-D-ribose 5-phosphate namespace: compound synonym: "C5H11O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11O7P/c6-3-1-5(7)12-4(3)2-11-13(8,9)10/h3-7H,1-2H2,(H2,8,9,10)/t3-,4+,5?/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16132 xref: CHEBI:55513 xref: KEGG:C00673 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00679 name: 5-dehydro-4-deoxy-D-glucarate namespace: compound synonym: "C6H8O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O7/c7-2(4(9)6(12)13)1-3(8)5(10)11/h2,4,7,9H,1H2,(H,10,11)(H,12,13)/t2-,4+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16369 xref: CHEBI:42819 xref: KEGG:C00679 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00680 name: DL-2,6-diaminopimelate namespace: compound synonym: "C7H14N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "DL-diaminopimelate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C7H14N2O4/c8-4(6(10)11)2-1-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5+" RELATED InChI [UPa:] xref: CHEBI:16488 xref: CHEBI:30308 xref: KEGG:C00680 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00681 name: 1-acyl-sn-glycerol 3-phosphate namespace: compound xref: CHEBI:16975 xref: KEGG:C00681 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00683 name: (S)-methylmalonyl-CoA namespace: compound synonym: "(S)-2-methyl-3-oxopropanoyl-CoA" EXACT [KEGG:KEGG] synonym: "C25H40N7O19P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/t12-,13+,16+,17+,18-,22+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15466 xref: KEGG:C00683 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00684 name: 2-dehydro-3-deoxy-L-arabinonate namespace: compound synonym: "C5H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O5/c6-2-3(7)1-4(8)5(9)10/h3,6-7H,1-2H2,(H,9,10)/t3-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17647 xref: KEGG:C00684 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00691 name: scyllo-inosose namespace: compound synonym: "2,4,6/3,5-pentahydroxycyclohexanone" EXACT [KEGG:KEGG] synonym: "C6H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-5,7-11H/t1-,2-,3+,4+,5-" RELATED InChI [UPa:] xref: CHEBI:17811 xref: KEGG:C00691 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00697 name: dinitrogen namespace: compound synonym: "InChI=1S/N2/c1-2" RELATED InChI [UPa:] synonym: "N2" RELATED FORMULA [KEGG:COMPOUND] xref: CHEBI:17997 xref: KEGG:C00697 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00698 name: chloride namespace: compound synonym: "Cl" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/ClH/h1H/p-1" RELATED InChI [UPa:] xref: CHEBI:17996 xref: KEGG:C00698 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00707 name: xylan namespace: compound xref: CHEBI:37166 xref: KEGG:C00707 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00714 name: pectin namespace: compound xref: CHEBI:17309 xref: KEGG:C00714 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00719 name: betaine namespace: compound synonym: "C5H11NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3" RELATED InChI [UPa:] xref: CHEBI:17750 xref: KEGG:C00719 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00725 name: lipoate namespace: compound synonym: "C8H14O2S2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)" RELATED InChI [UPa:] synonym: "lipoic acid" EXACT [KEGG:KEGG] xref: CHEBI:16494 xref: CHEBI:30314 xref: KEGG:C00725 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00748 name: siroheme namespace: compound synonym: "C42H44FeN4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C42H46N4O16.Fe/c1-41(17-39(59)60)23(5-9-35(51)52)29-14-27-21(11-37(55)56)19(3-7-33(47)48)25(43-27)13-26-20(4-8-34(49)50)22(12-38(57)58)28(44-26)15-31-42(2,18-40(61)62)24(6-10-36(53)54)30(46-31)16-32(41)45-29;/h13-16,23-24H,3-12,17-18H2,1-2H3,(H10,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62);/q;+2/p-2/t23-,24-,41+,42+;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:28599 xref: KEGG:C00748 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00750 name: spermine namespace: compound synonym: "C10H26N4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2" RELATED InChI [UPa:] xref: CHEBI:15746 xref: KEGG:C00750 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00751 name: squalene namespace: compound synonym: "C30H50" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+" RELATED InChI [UPa:] xref: CHEBI:15440 xref: KEGG:C00751 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00768 name: histidine namespace: compound synonym: "C6H9N3O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)" RELATED InChI [UPa:] xref: CHEBI:27570 xref: KEGG:C00768 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00770 name: L-idonate namespace: compound synonym: "C6H12O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3+,4-,5+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17796 xref: CHEBI:21336 xref: KEGG:C00770 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00780 name: serotonin namespace: compound synonym: "C10H12N2O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2" RELATED InChI [UPa:] xref: CHEBI:28790 xref: KEGG:C00780 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00785 name: trans-urocanate namespace: compound synonym: "C6H6N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H6N2O2/c9-6(10)2-1-5-3-7-4-8-5/h1-4H,(H,7,8)(H,9,10)/b2-1+" RELATED InChI [UPa:] synonym: "trans-urocanic acid" EXACT [KEGG:KEGG] xref: CHEBI:27247 xref: CHEBI:30817 xref: KEGG:C00785 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00788 name: (R)-adrenaline namespace: compound synonym: "C9H13NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "epinephrine" EXACT [KEGG:KEGG] synonym: "InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:28918 xref: KEGG:C00788 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00791 name: creatinine namespace: compound synonym: "C4H7N3O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)" RELATED InChI [UPa:] xref: CHEBI:16737 xref: KEGG:C00791 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00794 name: D-sorbitol namespace: compound synonym: "C6H14O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17924 xref: KEGG:C00794 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00797 name: ethylamine namespace: compound synonym: "C2H7N" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H7N/c1-2-3/h2-3H2,1H3" RELATED InChI [UPa:] xref: CHEBI:15862 xref: KEGG:C00797 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00798 name: formyl-CoA namespace: compound synonym: "C22H36N7O17P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/t12-,15-,16-,17+,21-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15522 xref: KEGG:C00798 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00800 name: L-gulonate namespace: compound synonym: "C6H12O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3+,4-,5-/m0/s1" RELATED InChI [UPa:] synonym: "L-gulonic acid" EXACT [KEGG:KEGG] xref: CHEBI:13115 xref: CHEBI:16154 xref: KEGG:C00800 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00802 name: oxalurate namespace: compound synonym: "C3H4N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H4N2O4/c4-3(9)5-1(6)2(7)8/h(H,7,8)(H3,4,5,6,9)" RELATED InChI [UPa:] synonym: "oxalureate" EXACT [KEGG:KEGG] xref: CHEBI:16582 xref: KEGG:C00802 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00805 name: salicylate namespace: compound synonym: "C7H6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)" RELATED InChI [UPa:] synonym: "salicylic acid" EXACT [KEGG:KEGG] xref: CHEBI:16914 xref: KEGG:C00805 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00806 name: tryptophan namespace: compound synonym: "C11H12N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)" RELATED InChI [UPa:] xref: CHEBI:27897 xref: KEGG:C00806 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00810 name: (R)-acetoin namespace: compound synonym: "C4H8O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H8O2/c1-3(5)4(2)6/h3,5H,1-2H3/t3-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15686 xref: KEGG:C00810 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00811 name: trans-4-coumarate namespace: compound synonym: "4-coumaric acid" EXACT [KEGG:KEGG] synonym: "C9H8O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+" RELATED InChI [UPa:] xref: CHEBI:32374 xref: KEGG:C00811 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00813 name: barbiturate namespace: compound synonym: "barbituric acid" EXACT [KEGG:KEGG] synonym: "C4H4N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H4N2O3/c7-2-1-3(8)6-4(9)5-2/h1H2,(H2,5,6,7,8,9)" RELATED InChI [UPa:] xref: CHEBI:16294 xref: CHEBI:29745 xref: KEGG:C00813 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00818 name: D-glucarate namespace: compound synonym: "C6H10O8" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-glucaric acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H10O8/c7-1(3(9)5(11)12)2(8)4(10)6(13)14/h1-4,7-10H,(H,11,12)(H,13,14)/t1-,2-,3-,4+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16002 xref: CHEBI:30612 xref: KEGG:C00818 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00826 name: L-arogenate namespace: compound synonym: "C10H13NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H13NO5/c11-7(8(13)14)5-10(9(15)16)3-1-6(12)2-4-10/h1-4,6-7,12H,5,11H2,(H,13,14)(H,15,16)/t6?,7-,10?/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17530 xref: KEGG:C00826 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00828 name: menaquinone-2 namespace: compound synonym: "C21H24O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C21H24O2/c1-14(2)8-7-9-15(3)12-13-17-16(4)20(22)18-10-5-6-11-19(18)21(17)23/h5-6,8,10-12H,7,9,13H2,1-4H3/b15-12+" RELATED InChI [UPa:] synonym: "menaquinone" EXACT [KEGG:KEGG] xref: CHEBI:16374 xref: KEGG:C00828 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00829 name: naphthalene namespace: compound synonym: "C10H8" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H8/c1-2-6-10-8-4-3-7-9(10)5-1/h1-8H" RELATED InChI [UPa:] xref: CHEBI:16482 xref: KEGG:C00829 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00846 name: 3-oxoadipate namespace: compound synonym: "C6H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O5/c7-4(3-6(10)11)1-2-5(8)9/h1-3H2,(H,8,9)(H,10,11)" RELATED InChI [UPa:] xref: CHEBI:15775 xref: CHEBI:37440 xref: KEGG:C00846 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00847 name: 4-pyridoxate namespace: compound synonym: "C8H9NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)" RELATED InChI [UPa:] xref: CHEBI:17405 xref: KEGG:C00847 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00857 name: deamido-NAD(+) namespace: compound synonym: "C21H27N6O15P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C21H26N6O15P2/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(31)14(29)11(41-20)6-39-44(36,37)42-43(34,35)38-5-10-13(28)15(30)19(40-10)26-3-1-2-9(4-26)21(32)33/h1-4,7-8,10-11,13-16,19-20,28-31H,5-6H2,(H4-,22,23,24,32,33,34,35,36,37)/p+1/t10-,11-,13-,14-,15-,16-,19-,20-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18304 xref: KEGG:C00857 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00860 name: L-histidinol namespace: compound synonym: "C6H11N3O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H11N3O/c7-5(3-10)1-6-2-8-4-9-6/h2,4-5,10H,1,3,7H2,(H,8,9)/t5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16255 xref: KEGG:C00860 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00861 name: L-rhamnulose namespace: compound synonym: "C6H12O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O5/c1-3(8)5(10)6(11)4(9)2-7/h3,5-8,10-11H,2H2,1H3/t3-,5-,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17897 xref: KEGG:C00861 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00862 name: methanofuran namespace: compound synonym: "C34H44N4O15" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C34H44N4O15/c35-16-22-15-20(18-53-22)17-52-21-3-1-19(2-4-21)13-14-36-27(39)10-7-25(33(48)49)38-29(41)11-8-26(34(50)51)37-28(40)9-5-23(31(44)45)24(32(46)47)6-12-30(42)43/h1-4,15,18,23-26H,5-14,16-17,35H2,(H,36,39)(H,37,40)(H,38,41)(H,42,43)(H,44,45)(H,46,47)(H,48,49)(H,50,51)/t23?,24?,25-,26-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17448 xref: KEGG:C00862 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00864 name: (R)-pantothenate namespace: compound synonym: "C9H17NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13)/t7-/m0/s1" RELATED InChI [UPa:] synonym: "pantothenate" EXACT [KEGG:KEGG] xref: CHEBI:25848 xref: CHEBI:29032 xref: CHEBI:46905 xref: CHEBI:7916 xref: KEGG:C00864 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00870 name: 4-nitrophenol namespace: compound synonym: "C6H5NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H" RELATED InChI [UPa:] xref: CHEBI:16836 xref: KEGG:C00870 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00875 name: cephalosporin namespace: compound xref: CHEBI:23066 xref: KEGG:C00875 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00876 name: coenzyme F420 namespace: compound synonym: "C29H36N5O18P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C29H36N5O18P/c1-12(25(42)31-17(28(46)47)4-6-21(38)30-16(27(44)45)5-7-22(39)40)52-53(49,50)51-11-20(37)23(41)19(36)10-34-18-9-14(35)3-2-13(18)8-15-24(34)32-29(48)33-26(15)43/h2-3,8-9,12,16-17,19-20,23,35-37,41H,4-7,10-11H2,1H3,(H,30,38)(H,31,42)(H,39,40)(H,44,45)(H,46,47)(H,49,50)(H,33,43,48)/t12-,16-,17-,19-,20+,23-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16848 xref: KEGG:C00876 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00877 name: crotonoyl-CoA namespace: compound synonym: "C25H40N7O17P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/b5-4+/t14-,18-,19-,20+,24-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15473 xref: CHEBI:36926 xref: KEGG:C00877 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00879 name: galactarate namespace: compound synonym: "C6H10O8" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-galactaric acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H10O8/c7-1(3(9)5(11)12)2(8)4(10)6(13)14/h1-4,7-10H,(H,11,12)(H,13,14)/t1-,2+,3+,4-" RELATED InChI [UPa:] xref: CHEBI:30852 xref: KEGG:C00879 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00880 name: D-galactonate namespace: compound synonym: "C6H12O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-galactonic acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3+,4+,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:12931 xref: CHEBI:16534 xref: KEGG:C00880 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00882 name: 3'-dephospho-CoA namespace: compound synonym: "C21H35N7O13P2S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/t11-,14-,15-,16+,20-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15468 xref: KEGG:C00882 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00885 name: isochorismate namespace: compound synonym: "C10H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H10O6/c1-5(9(12)13)16-7-4-2-3-6(8(7)11)10(14)15/h2-4,7-8,11H,1H2,(H,12,13)(H,14,15)/t7-,8-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17582 xref: CHEBI:29780 xref: KEGG:C00885 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00887 name: nitrous oxide namespace: compound synonym: "InChI=1S/N2O/c1-2-3" RELATED InChI [UPa:] synonym: "N2O" RELATED FORMULA [KEGG:COMPOUND] xref: CHEBI:17045 xref: KEGG:C00887 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00889 name: peptidoglycan namespace: compound xref: CHEBI:8005 xref: KEGG:C00889 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00898 name: L-tartrate namespace: compound synonym: "C4H6O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/t1-,2-/m1/s1" RELATED InChI [UPa:] synonym: "L-tartaric acid" EXACT [KEGG:KEGG] xref: CHEBI:15671 xref: CHEBI:15674 xref: CHEBI:30924 xref: KEGG:C00898 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00916 name: cephalosporin C namespace: compound synonym: "C16H21N3O8S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C16H21N3O8S/c1-7(20)27-5-8-6-28-14-11(13(22)19(14)12(8)16(25)26)18-10(21)4-2-3-9(17)15(23)24/h9,11,14H,2-6,17H2,1H3,(H,18,21)(H,23,24)(H,25,26)/t9-,11-,14-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15776 xref: KEGG:C00916 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00919 name: choline sulfate namespace: compound synonym: "C5H13NO4S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H13NO4S/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3" RELATED InChI [UPa:] xref: CHEBI:16822 xref: KEGG:C00919 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00921 name: 7,8-dihydropteroate namespace: compound synonym: "C14H14N6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "dihydropteroate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C14H14N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,16H,5-6H2,(H,22,23)(H4,15,17,19,20,21)" RELATED InChI [UPa:] xref: CHEBI:17839 xref: CHEBI:4581 xref: KEGG:C00921 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00922 name: dimethylmaleate namespace: compound synonym: "C6H8O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O4/c1-3(5(7)8)4(2)6(9)10/h1-2H3,(H,7,8)(H,9,10)/b4-3-" RELATED InChI [UPa:] xref: CHEBI:17081 xref: CHEBI:23812 xref: KEGG:C00922 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00931 name: porphobilinogen namespace: compound synonym: "C10H14N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H14N2O4/c11-4-8-7(3-10(15)16)6(5-12-8)1-2-9(13)14/h5,12H,1-4,11H2,(H,13,14)(H,15,16)" RELATED InChI [UPa:] xref: CHEBI:17381 xref: KEGG:C00931 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00935 name: UDP-L-arabinose namespace: compound synonym: "C14H22N2O16P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H22N2O16P2/c17-5-3-28-13(11(22)8(5)19)31-34(26,27)32-33(24,25)29-4-6-9(20)10(21)12(30-6)16-2-1-7(18)15-14(16)23/h1-2,5-6,8-13,17,19-22H,3-4H2,(H,24,25)(H,26,27)(H,15,18,23)/t5-,6+,8-,9+,10+,11+,12?,13+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17983 xref: KEGG:C00935 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00940 name: 2-oxoglutaramate namespace: compound synonym: "C5H7NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:16769 xref: CHEBI:30882 xref: KEGG:C00940 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00942 name: 3',5'-cyclic GMP namespace: compound synonym: "C10H12N5O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "cGMP" EXACT [KEGG:KEGG] synonym: "InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16356 xref: KEGG:C00942 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00944 name: 3-dehydroquinate namespace: compound synonym: "C7H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H10O6/c8-3-1-7(13,6(11)12)2-4(9)5(3)10/h3,5,8,10,13H,1-2H2,(H,11,12)/t3-,5+,7-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17947 xref: CHEBI:32364 xref: KEGG:C00944 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00954 name: ndole-3-acetate namespace: compound synonym: "C10H9NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H9NO2/c12-10(13)5-7-6-11-9-4-2-1-3-8(7)9/h1-4,6,11H,5H2,(H,12,13)" RELATED InChI [UPa:] synonym: "indole-3-acetate" EXACT [KEGG:KEGG] xref: CHEBI:16411 xref: KEGG:C00954 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00956 name: L-alpha-aminoadipate namespace: compound synonym: "C6H11NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:37023 xref: KEGG:C00956 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00966 name: 2-dehydropantoate namespace: compound synonym: "C6H10O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O4/c1-6(2,3-7)4(8)5(9)10/h7H,3H2,1-2H3,(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:11561 xref: CHEBI:17094 xref: KEGG:C00966 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00969 name: 3-hydroxypropanal namespace: compound synonym: "C3H6O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H6O2/c4-2-1-3-5/h2,5H,1,3H2" RELATED InChI [UPa:] xref: CHEBI:17871 xref: KEGG:C00969 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00971 name: 4-pyridoxolactone namespace: compound synonym: "C8H7NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H7NO3/c1-4-7(10)6-5(2-9-4)3-12-8(6)11/h2,10H,3H2,1H3" RELATED InChI [UPa:] xref: CHEBI:16871 xref: KEGG:C00971 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00976 name: GDP-D-mannuronate namespace: compound synonym: "C16H23N5O17P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C16H23N5O17P2/c17-16-19-11-4(12(27)20-16)18-2-21(11)13-8(25)5(22)3(35-13)1-34-39(30,31)38-40(32,33)37-15-9(26)6(23)7(24)10(36-15)14(28)29/h2-3,5-10,13,15,22-26H,1H2,(H,28,29)(H,30,31)(H,32,33)(H3,17,19,20,27)/t3-,5-,6+,7+,8-,9+,10+,13-,15-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:85507 xref: KEGG:C00976 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00978 name: N-acetylserotonin namespace: compound synonym: "C12H14N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)" RELATED InChI [UPa:] xref: CHEBI:17697 xref: KEGG:C00978 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00979 name: O-acetyl-L-serine namespace: compound synonym: "C5H9NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H9NO4/c1-3(7)10-2-4(6)5(8)9/h4H,2,6H2,1H3,(H,8,9)/t4-/m0/s1" RELATED InChI [UPa:] synonym: "O(3)-acetyl-L-serine" EXACT [KEGG:KEGG] xref: CHEBI:17981 xref: KEGG:C00979 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00986 name: 1,3-diaminopropane namespace: compound synonym: "C3H10N2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2" RELATED InChI [UPa:] xref: CHEBI:15725 xref: KEGG:C00986 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC00988 name: 2-phosphoglycolate namespace: compound synonym: "2-phosphoglycolic acid" EXACT [KEGG:KEGG] synonym: "C2H5O6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H5O6P/c3-2(4)1-8-9(5,6)7/h1H2,(H,3,4)(H2,5,6,7)" RELATED InChI [UPa:] xref: CHEBI:17150 xref: KEGG:C00988 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01001 name: N-formylmethanofuran namespace: compound synonym: "C35H44N4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "formylmethanofuran" EXACT [KEGG:KEGG] synonym: "InChI=1S/C35H44N4O16/c40-19-36-16-23-15-21(18-55-23)17-54-22-3-1-20(2-4-22)13-14-37-28(41)10-7-26(34(50)51)39-30(43)11-8-27(35(52)53)38-29(42)9-5-24(32(46)47)25(33(48)49)6-12-31(44)45/h1-4,15,18-19,24-27H,5-14,16-17H2,(H,36,40)(H,37,41)(H,38,42)(H,39,43)(H,44,45)(H,46,47)(H,48,49)(H,50,51)(H,52,53)/t24?,25?,26-,27-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16314 xref: KEGG:C01001 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01005 name: O-phospho-L-serine namespace: compound synonym: "C3H8NO6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15811 xref: KEGG:C01005 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01010 name: urea-1-carboxylate namespace: compound synonym: "C2H4N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H4N2O3/c3-1(5)4-2(6)7/h(H,6,7)(H3,3,4,5)" RELATED InChI [UPa:] xref: CHEBI:15832 xref: CHEBI:9889 xref: KEGG:C01010 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01019 name: L-fucose namespace: compound synonym: "C6H12O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6?/m0/s1" RELATED InChI [UPa:] xref: CHEBI:2181 xref: KEGG:C01019 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01020 name: 6-hydroxynicotinate namespace: compound synonym: "C6H5NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H5NO3/c8-5-2-1-4(3-7-5)6(9)10/h1-3H,(H,7,8)(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:16168 xref: KEGG:C01020 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01024 name: hydroxymethylbilane namespace: compound synonym: "C40H46N4O17" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H46N4O17/c45-17-32-25(12-40(60)61)21(4-8-36(52)53)29(44-32)15-31-24(11-39(58)59)20(3-7-35(50)51)28(43-31)14-30-23(10-38(56)57)19(2-6-34(48)49)27(42-30)13-26-22(9-37(54)55)18(16-41-26)1-5-33(46)47/h16,41-45H,1-15,17H2,(H,46,47)(H,48,49)(H,50,51)(H,52,53)(H,54,55)(H,56,57)(H,58,59)(H,60,61)" RELATED InChI [UPa:] xref: CHEBI:16645 xref: KEGG:C01024 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01026 name: N,N-dimethylglycine namespace: compound synonym: "C4H9NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "dimethylglycine" EXACT [KEGG:KEGG] synonym: "InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)" RELATED InChI [UPa:] xref: CHEBI:17724 xref: KEGG:C01026 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01031 name: S-formylglutathione namespace: compound synonym: "C11H17N3O7S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16225 xref: KEGG:C01031 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01036 name: 4-maleylacetoacetate namespace: compound synonym: "C8H8O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/b2-1-" RELATED InChI [UPa:] xref: CHEBI:17105 xref: CHEBI:47904 xref: KEGG:C01036 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01037 name: 7,8-diaminononanoate namespace: compound synonym: "C9H20N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H20N2O2/c1-7(10)8(11)5-3-2-4-6-9(12)13/h7-8H,2-6,10-11H2,1H3,(H,12,13)" RELATED InChI [UPa:] xref: CHEBI:17830 xref: CHEBI:2247 xref: KEGG:C01037 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01040 name: L-gulono-1,4-lactone namespace: compound synonym: "C6H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17587 xref: KEGG:C01040 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01043 name: N-carbamoylsarcosine namespace: compound synonym: "C4H8N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H8N2O3/c1-6(4(5)9)2-3(7)8/h2H2,1H3,(H2,5,9)(H,7,8)" RELATED InChI [UPa:] xref: CHEBI:15737 xref: KEGG:C01043 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01045 name: N-formyl-L-glutamate namespace: compound synonym: "C6H9NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H9NO5/c8-3-7-4(6(11)12)1-2-5(9)10/h3-4H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:48309 xref: KEGG:C01045 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01051 name: uroporphyrinogen III namespace: compound synonym: "C40H44N4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-27-19(3-7-35(49)50)22(10-38(55)56)30(43-27)15-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)16-31-23(11-39(57)58)18(2-6-34(47)48)26(42-31)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60)" RELATED InChI [UPa:] xref: CHEBI:15437 xref: KEGG:C01051 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01054 name: (S)-2,3-epoxysqualene namespace: compound synonym: "C30H50O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15441 xref: KEGG:C01054 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01056 name: (S)-6-hydroxynicotine namespace: compound synonym: "C10H14N2O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H14N2O/c1-12-6-2-3-9(12)8-4-5-10(13)11-7-8/h4-5,7,9H,2-3,6H2,1H3,(H,11,13)/t9-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17532 xref: KEGG:C01056 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01061 name: 4-fumarylacetoacetate namespace: compound synonym: "C8H8O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/b2-1+" RELATED InChI [UPa:] xref: CHEBI:18034 xref: CHEBI:30907 xref: KEGG:C01061 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01063 name: pimeloyl-CoA namespace: compound synonym: "6-carboxyhexanoyl-CoA" EXACT [KEGG:KEGG] synonym: "C28H46N7O19P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C28H46N7O19P3S/c1-28(2,23(41)26(42)31-9-8-17(36)30-10-11-58-19(39)7-5-3-4-6-18(37)38)13-51-57(48,49)54-56(46,47)50-12-16-22(53-55(43,44)45)21(40)27(52-16)35-15-34-20-24(29)32-14-33-25(20)35/h14-16,21-23,27,40-41H,3-13H2,1-2H3,(H,30,36)(H,31,42)(H,37,38)(H,46,47)(H,48,49)(H2,29,32,33)(H2,43,44,45)/t16-,21-,22-,23+,27-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15504 xref: KEGG:C01063 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01077 name: O-acetyl-L-homoserine namespace: compound synonym: "C6H11NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H11NO4/c1-4(8)11-3-2-5(7)6(9)10/h5H,2-3,7H2,1H3,(H,9,10)/t5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16288 xref: KEGG:C01077 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01079 name: protoporphyrinogen-IX namespace: compound synonym: "C34H40N4O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C34H40N4O4/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25/h7-8,35-38H,1-2,9-16H2,3-6H3,(H,39,40)(H,41,42)" RELATED InChI [UPa:] xref: CHEBI:15435 xref: KEGG:C01079 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01080 name: 1,5-dihydro-coenzyme F(420) namespace: compound synonym: "1,5-dihydrocoenzyme F420" EXACT [KEGG:KEGG] synonym: "C29H38N5O18P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C29H38N5O18P/c1-12(25(42)31-17(28(46)47)4-6-21(38)30-16(27(44)45)5-7-22(39)40)52-53(49,50)51-11-20(37)23(41)19(36)10-34-18-9-14(35)3-2-13(18)8-15-24(34)32-29(48)33-26(15)43/h2-3,9,12,16-17,19-20,23,35-37,41H,4-8,10-11H2,1H3,(H,30,38)(H,31,42)(H,39,40)(H,44,45)(H,46,47)(H,49,50)(H2,32,33,43,48)/t12-,16-,17-,19-,20+,23-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15823 xref: KEGG:C01080 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01081 name: thiamine phosphate namespace: compound synonym: "C12H18N4O4PS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p+1" RELATED InChI [UPa:] xref: CHEBI:9533 xref: KEGG:C01081 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01083 name: alpha,alpha-trehalose namespace: compound synonym: "C12H22O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H22O11/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16551 xref: KEGG:C01083 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01091 name: deacetylvindoline namespace: compound synonym: "C23H30N2O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C23H30N2O5/c1-5-21-9-6-11-25-12-10-22(17(21)25)15-8-7-14(29-3)13-16(15)24(2)18(22)23(28,19(21)26)20(27)30-4/h6-9,13,17-19,26,28H,5,10-12H2,1-4H3/t17-,18+,19+,21+,22+,23-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18362 xref: KEGG:C01091 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01092 name: 8-amino-7-oxononanoate namespace: compound synonym: "C9H17NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H17NO3/c1-7(10)8(11)5-3-2-4-6-9(12)13/h7H,2-6,10H2,1H3,(H,12,13)" RELATED InChI [UPa:] xref: CHEBI:12266 xref: CHEBI:15830 xref: KEGG:C01092 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01096 name: D-sorbitol 6-phosphate namespace: compound synonym: "C6H15O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H15O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h3-11H,1-2H2,(H2,12,13,14)/t3-,4+,5+,6+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17044 xref: KEGG:C01096 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01097 name: D-tagatose 6-phosphate namespace: compound synonym: "C6H13O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/t3-,4+,5+,6?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:4251 xref: KEGG:C01097 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01099 name: L-fuculose 1-phosphate namespace: compound synonym: "C6H13O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O8P/c1-3(7)5(9)6(10)4(8)2-14-15(11,12)13/h3,5-7,9-10H,2H2,1H3,(H2,11,12,13)/t3-,5+,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16647 xref: CHEBI:6220 xref: KEGG:C01099 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01100 name: L-histidinol phosphate namespace: compound synonym: "C6H12N3O4P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12N3O4P/c7-5(3-13-14(10,11)12)1-6-2-8-4-9-6/h2,4-5H,1,3,7H2,(H,8,9)(H2,10,11,12)/t5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16996 xref: KEGG:C01100 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01101 name: L-ribulose 5-phosphate namespace: compound synonym: "C5H11O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/t4-,5+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17666 xref: KEGG:C01101 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01102 name: O-phospho-L-homoserine namespace: compound synonym: "C4H10NO6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H10NO6P/c5-3(4(6)7)1-2-11-12(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15961 xref: KEGG:C01102 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01103 name: orotidine 5'-phosphate namespace: compound synonym: "C10H13N2O11P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H13N2O11P/c13-5-1-3(9(16)17)12(10(18)11-5)8-7(15)6(14)4(23-8)2-22-24(19,20)21/h1,4,6-8,14-15H,2H2,(H,16,17)(H,11,13,18)(H2,19,20,21)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15842 xref: KEGG:C01103 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01107 name: (R)-5-phosphomevalonate namespace: compound synonym: "C6H13O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/t6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17436 xref: KEGG:C01107 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01112 name: D-arabinose 5-phosphate namespace: compound synonym: "A5P" EXACT [KEGG:KEGG] synonym: "C5H11O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h1,3-5,7-9H,2H2,(H2,10,11,12)/t3-,4-,5+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16241 xref: KEGG:C01112 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01113 name: D-galactose 6-phosphate namespace: compound synonym: "C6H13O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3+,4+,5-,6?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17733 xref: CHEBI:4141 xref: KEGG:C01113 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01114 name: L-arabinono-1,4-lactone namespace: compound synonym: "C5H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O5/c6-1-2-3(7)4(8)5(9)10-2/h2-4,6-8H,1H2/t2-,3-,4+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17100 xref: KEGG:C01114 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01115 name: L-Galactono-1,4-lactone namespace: compound synonym: "C6H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3-,4-,5+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17464 xref: KEGG:C01115 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01118 name: O-succinyl-L-homoserine namespace: compound synonym: "C8H13NO6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H13NO6/c9-5(8(13)14)3-4-15-7(12)2-1-6(10)11/h5H,1-4,9H2,(H,10,11)(H,13,14)/t5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16160 xref: KEGG:C01118 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01131 name: L-rhamnulose 1-phosphate namespace: compound synonym: "C6H13O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O8P/c1-3(7)5(9)6(10)4(8)2-14-15(11,12)13/h3,5-7,9-10H,2H2,1H3,(H2,11,12,13)/t3-,5-,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17892 xref: KEGG:C01131 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01134 name: pantotheine 4'-phosphate namespace: compound synonym: "C11H23N2O7PS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/t9-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16858 xref: CHEBI:4222 xref: KEGG:C01134 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01137 name: S-adenosylmethioninamine namespace: compound synonym: "C14H23N6O3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H23N6O3S/c1-24(4-2-3-15)5-8-10(21)11(22)14(23-8)20-7-19-9-12(16)17-6-18-13(9)20/h6-8,10-11,14,21-22H,2-5,15H2,1H3,(H2,16,17,18)/q+1/t8-,10-,11-,14-,24?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15625 xref: KEGG:C01137 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01143 name: (R)-5-diphosphomevalonate namespace: compound synonym: "C6H14O10P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15899 xref: KEGG:C01143 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01146 name: 2-hydroxy-3-oxopropanoate namespace: compound synonym: "2-hydroxy-3-oxopropanoic acid" EXACT [KEGG:KEGG] synonym: "C3H4O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h1-2,5H,(H,6,7)" RELATED InChI [UPa:] xref: CHEBI:16992 xref: KEGG:C01146 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01151 name: D-ribose 1,5-bisphosphate namespace: compound synonym: "C5H12O11P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H12O11P2/c6-3-2(1-14-17(8,9)10)15-5(4(3)7)16-18(11,12)13/h2-7H,1H2,(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17994 xref: CHEBI:68819 xref: KEGG:C01151 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01159 name: 2,3-bisphospho-D-glycerate namespace: compound synonym: "2-phospho-D-glyceroyl phosphate" EXACT [KEGG:KEGG] synonym: "C3H8O10P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H8O10P2/c4-3(5)2(13-15(9,10)11)1-12-14(6,7)8/h2H,1H2,(H,4,5)(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17720 xref: KEGG:C01159 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01161 name: (3,4-dihydroxyphenyl)acetate namespace: compound synonym: "3,4-dihydroxyphenylacetate" EXACT [KEGG:KEGG] synonym: "C8H8O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)" RELATED InChI [UPa:] xref: CHEBI:17612 xref: CHEBI:41941 xref: KEGG:C01161 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01163 name: 3-carboxy-cis,cis-muconate namespace: compound synonym: "C7H6O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H6O6/c8-5(9)2-1-4(7(12)13)3-6(10)11/h1-3H,(H,8,9)(H,10,11)(H,12,13)/b2-1-,4-3+" RELATED InChI [UPa:] xref: CHEBI:15749 xref: KEGG:C01163 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01165 name: L-glutamate 5-semialdehyde namespace: compound synonym: "C5H9NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H9NO3/c6-4(5(8)9)2-1-3-7/h3-4H,1-2,6H2,(H,8,9)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17232 xref: KEGG:C01165 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01177 name: 1D-myo-inositol 1-phosphate namespace: compound synonym: "C6H13O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/t1-,2-,3+,4-,5-,6-/m1/s1" RELATED InChI [UPa:] synonym: "inositol 1-phosphate" EXACT [KEGG:KEGG] xref: CHEBI:18297 xref: KEGG:C01177 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01179 name: (4-hydroxyphenyl)pyruvate namespace: compound synonym: "4-hydroxyphenylpyruvate" EXACT [KEGG:KEGG] synonym: "C9H8O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)" RELATED InChI [UPa:] xref: CHEBI:15999 xref: CHEBI:36242 xref: KEGG:C01179 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01180 name: 4-methylthio-2-oxobutanoate namespace: compound synonym: "4-methylthio-2-oxobutanoic acid" EXACT [KEGG:KEGG] synonym: "C5H8O3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O3S/c1-9-3-2-4(6)5(7)8/h2-3H2,1H3,(H,7,8)" RELATED InChI [UPa:] xref: CHEBI:16723 xref: CHEBI:33574 xref: KEGG:C01180 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01185 name: nicotinate D-ribonucleotide namespace: compound synonym: "C11H15NO9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H14NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H2-,15,16,17,18,19)/p+1/t7-,8-,9-,10-/m1/s1" RELATED InChI [UPa:] synonym: "nicotinate ribonucleotide" EXACT [KEGG:KEGG] xref: CHEBI:15763 xref: KEGG:C01185 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01187 name: 3-deoxy-D-manno-octulosonate namespace: compound synonym: "C8H14O8" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H14O8/c9-2-5(12)7(14)6(13)3(10)1-4(11)8(15)16/h3,5-7,9-10,12-14H,1-2H2,(H,15,16)/t3-,5-,6-,7-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16064 xref: CHEBI:32817 xref: KEGG:C01187 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01210 name: N-methylethanolamine phosphate namespace: compound synonym: "C3H10NO4P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)" RELATED InChI [UPa:] xref: CHEBI:16463 xref: KEGG:C01210 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01213 name: (R)-methylmalonyl-CoA namespace: compound synonym: "(R)-2-methyl-3-oxopropanoyl-CoA" EXACT [KEGG:KEGG] synonym: "C25H40N7O19P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/t12-,13-,16-,17-,18+,22-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15465 xref: KEGG:C01213 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01216 name: 2-dehydro-3-deoxy-D-galactonate namespace: compound synonym: "C6H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O6/c7-2-5(10)3(8)1-4(9)6(11)12/h3,5,7-8,10H,1-2H2,(H,11,12)/t3-,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17028 xref: KEGG:C01216 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01217 name: 5,6,7,8-tetrahydromethanopterin namespace: compound synonym: "C30H45N6O16P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C30H45N6O16P/c1-12(21-13(2)33-26-22(34-21)27(44)36-30(31)35-26)32-15-5-3-14(4-6-15)9-16(37)23(41)17(38)10-49-29-25(43)24(42)19(51-29)11-50-53(47,48)52-18(28(45)46)7-8-20(39)40/h3-6,12-13,16-19,21,23-25,29,32,34,37-38,41-43H,7-11H2,1-2H3,(H,39,40)(H,45,46)(H,47,48)(H4,31,33,35,36,44)/t12-,13+,16+,17-,18+,19-,21+,23+,24-,25-,29+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17321 xref: KEGG:C01217 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01219 name: CDP-4-dehydro-6-deoxy-D-glucose namespace: compound synonym: "C15H23N3O15P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H23N3O15P2/c1-5-8(19)10(21)12(23)14(30-5)32-35(27,28)33-34(25,26)29-4-6-9(20)11(22)13(31-6)18-3-2-7(16)17-15(18)24/h2-3,5-6,9-14,20-23H,4H2,1H3,(H,25,26)(H,27,28)(H2,16,17,24)/t5-,6-,9-,10+,11-,12-,13-,14-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17494 xref: KEGG:C01219 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01222 name: GDP-4-dehydro-6-deoxy-D-mannose namespace: compound synonym: "C16H23N5O15P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16955 xref: KEGG:C01222 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01228 name: ppGpp namespace: compound synonym: "C10H17N5O17P4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H17N5O17P4/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6(30-36(26,27)32-34(21,22)23)3(29-9)1-28-35(24,25)31-33(18,19)20/h2-3,5-6,9,16H,1H2,(H,24,25)(H,26,27)(H2,18,19,20)(H2,21,22,23)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17633 xref: KEGG:C01228 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01234 name: 1-aminocyclopropanecarboxylate namespace: compound synonym: "1-aminocyclopropane-1-carboxylate" EXACT [KEGG:KEGG] synonym: "C4H7NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7)" RELATED InChI [UPa:] xref: CHEBI:18053 xref: CHEBI:30526 xref: KEGG:C01234 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01235 name: 1-alpha-D-galactosyl-myo-inositol namespace: compound synonym: "C12H22O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H22O11/c13-1-2-3(14)4(15)10(21)12(22-2)23-11-8(19)6(17)5(16)7(18)9(11)20/h2-21H,1H2/t2-,3+,4+,5-,6-,7+,8+,9+,10-,11-,12-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17505 xref: KEGG:C01235 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01236 name: D-glucono-1,5-lactone 6-phosphate namespace: compound synonym: "C6H11O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/t2-,3-,4+,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16938 xref: KEGG:C01236 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01250 name: N-acetyl-L-glutamate 5-semialdehyde namespace: compound synonym: "C7H11NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H11NO4/c1-5(10)8-6(7(11)12)3-2-4-9/h4,6H,2-3H2,1H3,(H,8,10)(H,11,12)/t6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16319 xref: CHEBI:29123 xref: KEGG:C01250 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01251 name: (R)-homocitrate namespace: compound synonym: "C7H10O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "homocitrate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C7H10O7/c8-4(9)1-2-7(14,6(12)13)3-5(10)11/h14H,1-3H2,(H,8,9)(H,10,11)(H,12,13)/t7-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17852 xref: CHEBI:36457 xref: CHEBI:52222 xref: KEGG:C01251 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01252 name: 4-(2-aminophenyl)-2,4-dioxobutanoate namespace: compound synonym: "C10H9NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)" RELATED InChI [UPa:] xref: CHEBI:17442 xref: KEGG:C01252 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01267 name: imidazole-acetol phosphate namespace: compound synonym: "C6H9N2O5P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H9N2O5P/c9-6(3-13-14(10,11)12)1-5-2-7-4-8-5/h2,4H,1,3H2,(H,7,8)(H2,10,11,12)" RELATED InChI [UPa:] xref: CHEBI:16426 xref: KEGG:C01267 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01268 name: 5-amino-6-(5-phosphoribosylamino)uracil namespace: compound synonym: "C9H15N4O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H15N4O9P/c10-3-6(12-9(17)13-7(3)16)11-8-5(15)4(14)2(22-8)1-21-23(18,19)20/h2,4-5,8,14-15H,1,10H2,(H2,18,19,20)(H3,11,12,13,16,17)/t2-,4-,5-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18337 xref: KEGG:C01268 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01269 name: 5-O-(1-carboxyvinyl)-3-phosphoshikimate namespace: compound synonym: "C10H13O10P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H13O10P/c1-4(9(12)13)19-6-2-5(10(14)15)3-7(8(6)11)20-21(16,17)18/h3,6-8,11H,1-2H2,(H,12,13)(H,14,15)(H2,16,17,18)/t6-,7-,8+/m1/s1" RELATED InChI [UPa:] synonym: "O(5)-(1-carboxyvinyl)-3-phosphoshikimate" EXACT [KEGG:KEGG] xref: CHEBI:16257 xref: KEGG:C01269 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01273 name: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate namespace: compound synonym: "C12H10O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H10O4/c13-10(9-5-2-1-3-6-9)7-4-8-11(14)12(15)16/h1-8,14H,(H,15,16)/b7-4-,11-8+" RELATED InChI [UPa:] xref: CHEBI:17820 xref: KEGG:C01273 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01274 name: N(5)-formyl-5,6,7,8-tetrahydromethanopterin namespace: compound synonym: "5-formyl-5,6,7,8-tetrahydromethanopterin" EXACT [KEGG:KEGG] synonym: "C31H45N6O17P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C31H45N6O17P/c1-13(22-14(2)34-27-23(37(22)12-38)28(46)36-31(32)35-27)33-16-5-3-15(4-6-16)9-17(39)24(43)18(40)10-51-30-26(45)25(44)20(53-30)11-52-55(49,50)54-19(29(47)48)7-8-21(41)42/h3-6,12-14,17-20,22,24-26,30,33,39-40,43-45H,7-11H2,1-2H3,(H,41,42)(H,47,48)(H,49,50)(H4,32,34,35,36,46)/t13-,14+,17+,18-,19+,20-,22+,24+,25-,26-,30+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17114 xref: KEGG:C01274 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01278 name: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate namespace: compound synonym: "C7H6O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H6O6/c8-4(9)3-7(6(11)12)2-1-5(10)13-7/h1-2H,3H2,(H,8,9)(H,11,12)" RELATED InChI [UPa:] xref: CHEBI:16993 xref: KEGG:C01278 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01279 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine namespace: compound synonym: "C6H9N3O" RELATED FORMULA [KEGG:COMPOUND] synonym: "HMP" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H9N3O/c1-4-8-2-5(3-10)6(7)9-4/h2,10H,3H2,1H3,(H2,7,8,9)" RELATED InChI [UPa:] xref: CHEBI:16892 xref: KEGG:C01279 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01286 name: 6-phospho-2-dehydro-3-deoxy-D-galactonic acid namespace: compound synonym: "2-dehydro-3-deoxy-D-galactonate 6-phosphate" EXACT [KEGG:KEGG] synonym: "C6H11O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H11O9P/c7-3(1-4(8)6(10)11)5(9)2-15-16(12,13)14/h3,5,7,9H,1-2H2,(H,10,11)(H2,12,13,14)/t3-,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17860 xref: KEGG:C01286 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01297 name: 6-hydroxypseudooxynicotine namespace: compound synonym: "C10H14N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H14N2O2/c1-11-6-2-3-9(13)8-4-5-10(14)12-7-8/h4-5,7,11H,2-3,6H2,1H3,(H,12,14)" RELATED InChI [UPa:] xref: CHEBI:37754 xref: KEGG:C01297 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01300 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine namespace: compound synonym: "C7H9N5O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H9N5O2/c8-7-11-5-4(6(14)12-7)10-3(2-13)1-9-5/h13H,1-2H2,(H4,8,9,11,12,14)" RELATED InChI [UPa:] xref: CHEBI:17083 xref: CHEBI:44841 xref: KEGG:C01300 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01302 name: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate namespace: compound synonym: "1-(2-carboxyphenylamino)-1'-deoxy-ribulose 5'-phosphate" EXACT [KEGG:KEGG] synonym: "C12H16NO9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H16NO9P/c14-9(11(16)10(15)6-22-23(19,20)21)5-13-8-4-2-1-3-7(8)12(17)18/h1-4,10-11,13,15-16H,5-6H2,(H,17,18)(H2,19,20,21)/t10-,11+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:29112 xref: KEGG:C01302 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01304 name: 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine namespace: compound synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine" EXACT [KEGG:KEGG] synonym: "C9H16N5O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H16N5O8P/c10-3-6(13-9(11)14-7(3)17)12-8-5(16)4(15)2(22-8)1-21-23(18,19)20/h2,4-5,8,15-16H,1,10H2,(H2,18,19,20)(H4,11,12,13,14,17)/t2-,4-,5-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:29114 xref: CHEBI:59546 xref: KEGG:C01304 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01327 name: HCl namespace: compound synonym: "ClH" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/ClH/h1H" RELATED InChI [UPa:] xref: CHEBI:17883 xref: KEGG:C01327 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01328 name: OH(-) namespace: compound synonym: "HO" RELATED FORMULA [KEGG:COMPOUND] synonym: "hydroxide" EXACT [KEGG:KEGG] synonym: "InChI=1S/H2O/h1H2/p-1" RELATED InChI [UPa:] xref: CHEBI:16234 xref: KEGG:C01328 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01352 name: FADH2 namespace: compound synonym: "C27H35N9O15P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17877 xref: KEGG:C01352 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01353 name: carbonic acid namespace: compound synonym: "CH2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)" RELATED InChI [UPa:] xref: CHEBI:28976 xref: KEGG:C01353 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01359 name: pyrroloquinoline quinol namespace: compound synonym: "C14H8N2O8" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H8N2O8/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18/h1-2,15,17-18H,(H,19,20)(H,21,22)(H,23,24)" RELATED InChI [UPa:] synonym: "PQQH2" EXACT [KEGG:KEGG] xref: CHEBI:18356 xref: KEGG:C01359 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01371 name: alkane namespace: compound xref: CHEBI:18310 xref: KEGG:C01371 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01401 name: alanine namespace: compound synonym: "C3H7NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)" RELATED InChI [UPa:] xref: CHEBI:16449 xref: KEGG:C01401 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01407 name: benzene namespace: compound synonym: "C6H6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H6/c1-2-4-6-5-3-1/h1-6H" RELATED InChI [UPa:] xref: CHEBI:16716 xref: KEGG:C01407 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01416 name: cocaine namespace: compound synonym: "C17H21NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:27958 xref: KEGG:C01416 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01432 name: lactate namespace: compound synonym: "C3H6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)" RELATED InChI [UPa:] xref: CHEBI:24996 xref: CHEBI:28358 xref: CHEBI:78320 xref: KEGG:C01432 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01438 name: methane namespace: compound synonym: "CH4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/CH4/h1H4" RELATED InChI [UPa:] xref: CHEBI:16183 xref: KEGG:C01438 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01449 name: queuine namespace: compound synonym: "7-aminomethyl-7-deazaguanine" EXACT [KEGG:KEGG] synonym: "C12H15N5O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H15N5O3/c13-12-16-10-8(11(20)17-12)5(4-15-10)3-14-6-1-2-7(18)9(6)19/h1-2,4,6-7,9,14,18-19H,3H2,(H4,13,15,16,17,20)/t6-,7-,9+/m0/s1" RELATED InChI [UPa:] synonym: "preQ1" EXACT [KEGG:KEGG] xref: CHEBI:17433 xref: KEGG:C01449 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01450 name: ketone namespace: compound xref: CHEBI:17087 xref: KEGG:C01450 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01455 name: toluene namespace: compound synonym: "C7H8" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H8/c1-7-5-3-2-4-6-7/h2-6H,1H3" RELATED InChI [UPa:] xref: CHEBI:17578 xref: KEGG:C01455 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01457 name: tylosin namespace: compound synonym: "C46H77NO17" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C46H77NO17/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3/b15-14+,23-18+/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17658 xref: KEGG:C01457 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01579 name: flavonoid namespace: compound xref: CHEBI:47916 xref: KEGG:C01579 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01582 name: galactose namespace: compound synonym: "C6H12O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4+,5+,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:28061 xref: CHEBI:28260 xref: KEGG:C01582 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01598 name: melatonin namespace: compound synonym: "C13H16N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)" RELATED InChI [UPa:] xref: CHEBI:16796 xref: KEGG:C01598 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01606 name: phthalate namespace: compound synonym: "C8H6O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H6O4/c9-7(10)5-3-1-2-4-6(5)8(11)12/h1-4H,(H,9,10)(H,11,12)" RELATED InChI [UPa:] synonym: "phtalic acid" EXACT [KEGG:KEGG] xref: CHEBI:17563 xref: CHEBI:29069 xref: KEGG:C01606 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01613 name: stachyose namespace: compound synonym: "C24H42O21" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C24H42O21/c25-1-6-10(28)14(32)17(35)21(41-6)39-3-8-11(29)15(33)18(36)22(42-8)40-4-9-12(30)16(34)19(37)23(43-9)45-24(5-27)20(38)13(31)7(2-26)44-24/h6-23,25-38H,1-5H2/t6-,7-,8-,9-,10+,11+,12-,13-,14+,15+,16+,17-,18-,19-,20+,21+,22+,23-,24+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17164 xref: KEGG:C01613 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01626 name: vindoline namespace: compound synonym: "C25H32N2O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C25H32N2O6/c1-6-23-10-7-12-27-13-11-24(19(23)27)17-9-8-16(31-4)14-18(17)26(3)20(24)25(30,22(29)32-5)21(23)33-15(2)28/h7-10,14,19-21,30H,6,11-13H2,1-5H3/t19-,20+,21+,23+,24+,25-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16380 xref: KEGG:C01626 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01641 name: tRNA(Glu) namespace: compound xref: CHEBI:29175 xref: KEGG:C01641 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01667 name: bacitracin namespace: compound xref: CHEBI:28669 xref: KEGG:C01667 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01678 name: 2-aminoethanethiol namespace: compound synonym: "C2H7NS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2" RELATED InChI [UPa:] xref: CHEBI:17141 xref: KEGG:C01678 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01682 name: nopaline namespace: compound synonym: "C11H20N4O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H20N4O6/c12-11(13)14-5-1-2-6(9(18)19)15-7(10(20)21)3-4-8(16)17/h6-7,15H,1-5H2,(H,16,17)(H,18,19)(H,20,21)(H4,12,13,14)/t6-,7+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17249 xref: KEGG:C01682 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01694 name: ergosterol namespace: compound synonym: "C28H44O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C28H44O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,18-20,22,24-26,29H,11-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,26-,27-,28+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16933 xref: KEGG:C01694 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01717 name: kynurenate namespace: compound synonym: "C10H7NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)" RELATED InChI [UPa:] synonym: "kynurenic acid" EXACT [KEGG:KEGG] xref: CHEBI:18344 xref: KEGG:C01717 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01721 name: L-fuculose namespace: compound synonym: "C6H12O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O5/c1-3(8)5(10)6(11)4(9)2-7/h3,5-8,10-11H,2H2,1H3/t3-,5+,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17617 xref: KEGG:C01721 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01724 name: lanosterol namespace: compound synonym: "C30H50O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16521 xref: KEGG:C01724 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01732 name: mesaconate namespace: compound synonym: "C5H6O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/b3-2+" RELATED InChI [UPa:] synonym: "mesaconic acid" EXACT [KEGG:KEGG] xref: CHEBI:16600 xref: CHEBI:36986 xref: KEGG:C01732 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01742 name: palatinose namespace: compound synonym: "C12H22O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H22O11/c13-1-4-6(15)8(17)9(18)11(22-4)21-2-5-7(16)10(19)12(20,3-14)23-5/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11+,12?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18394 xref: KEGG:C01742 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01748 name: pyocyanine namespace: compound synonym: "C13H12N2O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C13H12N2O/c1-15-10-6-3-2-5-9(10)14-13-11(15)7-4-8-12(13)16/h2-8,14,16H,1H3" RELATED InChI [UPa:] xref: CHEBI:8653 xref: KEGG:C01748 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01762 name: xanthosine namespace: compound synonym: "C10H12N4O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18107 xref: KEGG:C01762 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01768 name: alginate namespace: compound xref: CHEBI:17548 xref: KEGG:C01768 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01795 name: columbamine namespace: compound synonym: "C20H20NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-17(22)19(24-2)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1" RELATED InChI [UPa:] xref: CHEBI:15920 xref: KEGG:C01795 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01825 name: alpha-L-galactose namespace: compound synonym: "C6H12O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6?/m0/s1" RELATED InChI [UPa:] synonym: "L-galactose" EXACT [KEGG:KEGG] xref: CHEBI:42905 xref: KEGG:C01825 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01841 name: pentalenene namespace: compound synonym: "C15H24" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H24/c1-10-7-12-8-14(3,4)9-15(12)11(2)5-6-13(10)15/h7,11-13H,5-6,8-9H2,1-4H3/t11-,12-,13+,15?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17251 xref: KEGG:C01841 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01847 name: FMNH(2) namespace: compound synonym: "C17H23N4O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "FMNH2" EXACT [KEGG:KEGG] synonym: "InChI=1S/C17H23N4O9P/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29/h3-4,11-12,14,18,22-24H,5-6H2,1-2H3,(H2,27,28,29)(H2,19,20,25,26)/t11-,12+,14-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16048 xref: KEGG:C01847 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01848 name: rifamycin B namespace: compound synonym: "C39H49NO14" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C39H49NO14/c1-17-11-10-12-18(2)38(49)40-24-15-26(51-16-27(42)43)28-29(34(24)47)33(46)22(6)36-30(28)37(48)39(8,54-36)52-14-13-25(50-9)19(3)35(53-23(7)41)21(5)32(45)20(4)31(17)44/h10-15,17,19-21,25,31-32,35,44-47H,16H2,1-9H3,(H,40,49)(H,42,43)/b11-10+,14-13+,18-12-/t17-,19+,20+,21+,25-,31-,32+,35+,39-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17876 xref: KEGG:C01848 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01852 name: secologanin namespace: compound synonym: "C17H24O10" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C17H24O10/c1-3-8-9(4-5-18)10(15(23)24-2)7-25-16(8)27-17-14(22)13(21)12(20)11(6-19)26-17/h3,5,7-9,11-14,16-17,19-22H,1,4,6H2,2H3/t8-,9+,11-,12-,13+,14-,16+,17+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18002 xref: KEGG:C01852 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01909 name: dethiobiotin namespace: compound synonym: "C10H18N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H18N2O3/c1-7-8(12-10(15)11-7)5-3-2-4-6-9(13)14/h7-8H,2-6H2,1H3,(H,13,14)(H2,11,12,15)" RELATED InChI [UPa:] xref: CHEBI:16691 xref: KEGG:C01909 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01977 name: tRNA-guanine namespace: compound xref: CHEBI:17022 xref: KEGG:C01977 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01978 name: tRNA-queuine namespace: compound xref: CHEBI:16969 xref: KEGG:C01978 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01983 name: (R)-mandelate namespace: compound synonym: "(R)-mandelic acid" EXACT [KEGG:KEGG] synonym: "C8H8O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H8O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7,9H,(H,10,11)/t7-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17656 xref: CHEBI:32382 xref: KEGG:C01983 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC01984 name: (S)-mandelate namespace: compound synonym: "C8H8O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H8O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7,9H,(H,10,11)/t7-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17756 xref: CHEBI:32800 xref: KEGG:C01984 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02004 name: aristolochene namespace: compound synonym: "C15H24" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H24/c1-11(2)13-8-9-14-7-5-6-12(3)15(14,4)10-13/h9,12-13H,1,5-8,10H2,2-4H3/t12-,13-,15+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18027 xref: CHEBI:43445 xref: KEGG:C02004 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02020 name: cyclopentanol namespace: compound synonym: "C5H10O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10O/c6-5-3-1-2-4-5/h5-6H,1-4H2" RELATED InChI [UPa:] xref: CHEBI:16133 xref: KEGG:C02020 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02059 name: phylloquinone namespace: compound synonym: "C31H46O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+" RELATED InChI [UPa:] xref: CHEBI:18067 xref: KEGG:C02059 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02091 name: 2-ureidoglycine namespace: compound synonym: "C3H7N3O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7N3O3/c4-1(2(7)8)6-3(5)9/h1H,4H2,(H,7,8)(H3,5,6,9)/t1-/m0/s1" RELATED InChI [UPa:] synonym: "ureidoglycine" EXACT [KEGG:KEGG] xref: CHEBI:16282 xref: CHEBI:59945 xref: KEGG:C02091 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02105 name: (S)-reticuline namespace: compound synonym: "C19H23NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C19H23NO4/c1-20-7-6-13-10-19(24-3)17(22)11-14(13)15(20)8-12-4-5-18(23-2)16(21)9-12/h4-5,9-11,15,21-22H,6-8H2,1-3H3/t15-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16718 xref: KEGG:C02105 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02106 name: (S)-scoulerine namespace: compound synonym: "C19H21NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C19H21NO4/c1-23-17-4-3-11-7-15-13-9-16(21)18(24-2)8-12(13)5-6-20(15)10-14(11)19(17)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17129 xref: KEGG:C02106 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02112 name: 2-acylglycerol namespace: compound xref: CHEBI:17389 xref: KEGG:C02112 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02137 name: phenylglyoxylate namespace: compound synonym: "C8H6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H6O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5H,(H,10,11)" RELATED InChI [UPa:] synonym: "phenylglyoxylic acid" EXACT [KEGG:KEGG] xref: CHEBI:18280 xref: KEGG:C02137 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02191 name: protoporphyrin-IX namespace: compound synonym: "C34H34N4O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C34H34N4O4/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25/h7-8,13-16,35,38H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42)/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-" RELATED InChI [UPa:] xref: CHEBI:15430 xref: KEGG:C02191 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02222 name: maleylacetate namespace: compound synonym: "2-maleylacetate" EXACT [KEGG:KEGG] synonym: "C6H6O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H6O5/c7-4(3-6(10)11)1-2-5(8)9/h1-2H,3H2,(H,8,9)(H,10,11)/b2-1-" RELATED InChI [UPa:] xref: CHEBI:1184 xref: CHEBI:16468 xref: KEGG:C02222 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02226 name: 2-methylmaleate namespace: compound synonym: "C5H6O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/b3-2-" RELATED InChI [UPa:] xref: CHEBI:17626 xref: CHEBI:30719 xref: KEGG:C02226 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02232 name: 3-oxoadipyl-CoA namespace: compound synonym: "C27H42N7O20P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C27H42N7O20P3S/c1-27(2,22(41)25(42)30-6-5-16(36)29-7-8-58-18(39)9-14(35)3-4-17(37)38)11-51-57(48,49)54-56(46,47)50-10-15-21(53-55(43,44)45)20(40)26(52-15)34-13-33-19-23(28)31-12-32-24(19)34/h12-13,15,20-22,26,40-41H,3-11H2,1-2H3,(H,29,36)(H,30,42)(H,37,38)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t15-,20-,21-,22+,26-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15490 xref: KEGG:C02232 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02240 name: 5-valerolactone namespace: compound synonym: "C5H8O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O2/c6-5-3-1-2-4-7-5/h1-4H2" RELATED InChI [UPa:] xref: CHEBI:16545 xref: KEGG:C02240 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02280 name: GDP-L-galactose namespace: compound synonym: "C16H25N5O16P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/t4-,5+,7+,8+,9+,10+,11-,14+,15+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18038 xref: CHEBI:42660 xref: KEGG:C02280 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02291 name: L-cystathionine namespace: compound synonym: "C7H14N2O4S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17482 xref: KEGG:C02291 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02295 name: 2-methylene-3-methylsuccinate namespace: compound synonym: "C6H8O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O4/c1-3(5(7)8)4(2)6(9)10/h4H,1H2,2H3,(H,7,8)(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:16093 xref: KEGG:C02295 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02315 name: protein dithiol namespace: compound xref: CHEBI:17999 xref: KEGG:C02315 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02350 name: (S)-allantoin namespace: compound synonym: "C4H6N4O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,11)/t1-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15678 xref: KEGG:C02350 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02370 name: 4-chlorobenzoate namespace: compound synonym: "C7H5ClO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H5ClO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:17861 xref: CHEBI:30747 xref: KEGG:C02370 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02385 name: arginine namespace: compound synonym: "C6H14N4O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)" RELATED InChI [UPa:] xref: CHEBI:29016 xref: KEGG:C02385 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02411 name: glutaconyl-1-CoA namespace: compound synonym: "C26H40N7O19P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C26H40N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h3,5,12-14,19-21,25,38-39H,4,6-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b5-3+/t14-,19-,20-,21+,25-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15497 xref: KEGG:C02411 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02457 name: propane-1,3-diol namespace: compound synonym: "C3H8O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H8O2/c4-2-1-3-5/h4-5H,1-3H2" RELATED InChI [UPa:] xref: CHEBI:16109 xref: KEGG:C02457 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02463 name: precorrin-2 namespace: compound synonym: "C42H48N4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C42H48N4O16/c1-41(17-39(59)60)23(5-9-35(51)52)29-14-27-21(11-37(55)56)19(3-7-33(47)48)25(43-27)13-26-20(4-8-34(49)50)22(12-38(57)58)28(44-26)15-31-42(2,18-40(61)62)24(6-10-36(53)54)30(46-31)16-32(41)45-29/h14-16,23-24,43-44,46H,3-13,17-18H2,1-2H3,(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H,61,62)/b29-14-,30-16-,31-15-/t23-,24-,41+,42+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:50602 xref: KEGG:C02463 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02477 name: tocopherol namespace: compound synonym: "C29H50O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18145 xref: KEGG:C02477 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02480 name: cis,cis-muconate namespace: compound synonym: "C6H6O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "cis,cis-hexanedioate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H6O4/c7-5(8)3-1-2-4-6(9)10/h1-4H,(H,7,8)(H,9,10)/b3-1-,4-2-" RELATED InChI [UPa:] xref: CHEBI:16508 xref: KEGG:C02480 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02501 name: 2-hydroxymuconate namespace: compound synonym: "2-hydroxymuconic acid" EXACT [KEGG:KEGG] synonym: "C6H6O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H6O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3,7H,(H,8,9)(H,10,11)/b3-1-,4-2+" RELATED InChI [UPa:] xref: CHEBI:64016 xref: CHEBI:64037 xref: KEGG:C02501 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02504 name: (2S)-2-isopropylmalate namespace: compound synonym: "2-isopropylmalate" EXACT [KEGG:KEGG] synonym: "C7H12O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H12O5/c1-4(2)7(12,6(10)11)3-5(8)9/h4,12H,3H2,1-2H3,(H,8,9)(H,10,11)/t7-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:1178 xref: CHEBI:35128 xref: KEGG:C02504 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02526 name: biphenyl-2,3-diol namespace: compound synonym: "C12H10O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H10O2/c13-11-8-4-7-10(12(11)14)9-5-2-1-3-6-9/h1-8,13-14H" RELATED InChI [UPa:] xref: CHEBI:16205 xref: KEGG:C02526 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02565 name: N-methylhydantoin namespace: compound synonym: "C4H6N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H6N2O2/c1-6-2-3(7)5-4(6)8/h2H2,1H3,(H,5,7,8)" RELATED InChI [UPa:] xref: CHEBI:16354 xref: KEGG:C02565 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02582 name: protein disulfide namespace: compound xref: CHEBI:16249 xref: KEGG:C02582 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02591 name: sucrose 6-phosphate namespace: compound synonym: "C12H23O14P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H23O14P/c13-1-4-6(15)8(17)9(18)11(24-4)26-12(3-14)10(19)7(16)5(25-12)2-23-27(20,21)22/h4-11,13-19H,1-3H2,(H2,20,21,22)/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16308 xref: KEGG:C02591 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02612 name: (R)-citramalate namespace: compound synonym: "C5H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-citramalate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C5H8O5/c1-5(10,4(8)9)2-3(6)7/h10H,2H2,1H3,(H,6,7)(H,8,9)/t5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15586 xref: CHEBI:30934 xref: KEGG:C02612 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02614 name: L-citramalate namespace: compound synonym: "C5H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O5/c1-5(10,4(8)9)2-3(6)7/h10H,2H2,1H3,(H,6,7)(H,8,9)/t5-/m0/s1" RELATED InChI [UPa:] synonym: "L-citramalic acid" EXACT [KEGG:KEGG] xref: CHEBI:29003 xref: CHEBI:30936 xref: KEGG:C02614 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02627 name: 2-deoxystreptamine namespace: compound synonym: "C6H14N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H14N2O3/c7-2-1-3(8)5(10)6(11)4(2)9/h2-6,9-11H,1,7-8H2/t2-,3+,4+,5-,6-" RELATED InChI [UPa:] xref: CHEBI:28295 xref: KEGG:C02627 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02630 name: 2-hydroxyglutarate namespace: compound synonym: "2-hydroxyglutaric acid" EXACT [KEGG:KEGG] synonym: "C5H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:17084 xref: KEGG:C02630 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02631 name: 2-isopropylmaleate namespace: compound synonym: "C7H10O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H10O4/c1-4(2)5(7(10)11)3-6(8)9/h3-4H,1-2H3,(H,8,9)(H,10,11)/b5-3-" RELATED InChI [UPa:] xref: CHEBI:17275 xref: KEGG:C02631 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02632 name: 2-methylpropanoate namespace: compound synonym: "C4H8O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H8O2/c1-3(2)4(5)6/h3H,1-2H3,(H,5,6)" RELATED InChI [UPa:] synonym: "isobutyric acid" EXACT [KEGG:KEGG] xref: CHEBI:16135 xref: KEGG:C02632 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02637 name: 3-dehydroshikimate namespace: compound synonym: "C7H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H8O5/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1,5-6,9-10H,2H2,(H,11,12)/t5-,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16630 xref: CHEBI:30918 xref: KEGG:C02637 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02656 name: pimelate namespace: compound synonym: "6-carboxyhexanoate" EXACT [KEGG:KEGG] synonym: "C7H12O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H12O4/c8-6(9)4-2-1-3-5-7(10)11/h1-5H2,(H,8,9)(H,10,11)" RELATED InChI [UPa:] xref: CHEBI:30531 xref: KEGG:C02656 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02673 name: desacetoxyvindoline namespace: compound synonym: "C23H30N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C23H30N2O4/c1-5-21-9-6-11-25-12-10-22(18(21)25)16-8-7-15(28-3)13-17(16)24(2)19(22)23(27,14-21)20(26)29-4/h6-9,13,18-19,27H,5,10-12,14H2,1-4H3/t18-,19+,21-,22+,23+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16957 xref: KEGG:C02673 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02700 name: N-formyl-N-kynurenine namespace: compound synonym: "C11H12N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H12N2O4/c12-8(11(16)17)5-10(15)7-3-1-2-4-9(7)13-6-14/h1-4,6,8H,5,12H2,(H,13,14)(H,16,17)/t8-/m0/s1" RELATED InChI [UPa:] synonym: "N-formyl-L-kynurenine" EXACT [KEGG:KEGG] xref: CHEBI:30249 xref: KEGG:C02700 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02713 name: N-acetylmuramate namespace: compound synonym: "C11H19NO8" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H19NO8/c1-4(10(16)17)19-9-7(12-5(2)14)11(18)20-6(3-13)8(9)15/h4,6-9,11,13,15,18H,3H2,1-2H3,(H,12,14)(H,16,17)/t4-,6-,7-,8-,9-,11?/m1/s1" RELATED InChI [UPa:] synonym: "N-acetylmuramic acid" EXACT [KEGG:KEGG] xref: CHEBI:21615 xref: CHEBI:28881 xref: KEGG:C02713 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02714 name: N-acetylputrescine namespace: compound synonym: "C6H14N2O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H14N2O/c1-6(9)8-5-3-2-4-7/h2-5,7H2,1H3,(H,8,9)" RELATED InChI [UPa:] xref: CHEBI:17768 xref: KEGG:C02714 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02727 name: N(6)-acetyl-L-lysine namespace: compound synonym: "C8H16N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H16N2O3/c1-6(11)10-5-3-2-4-7(9)8(12)13/h7H,2-5,9H2,1H3,(H,10,11)(H,12,13)/t7-/m0/s1" RELATED InChI [UPa:] synonym: "N6-acetyl-L-lysine" EXACT [KEGG:KEGG] xref: CHEBI:17752 xref: KEGG:C02727 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02730 name: 2-succinylbenzoate namespace: compound synonym: "C11H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H10O5/c12-9(5-6-10(13)14)7-3-1-2-4-8(7)11(15)16/h1-4H,5-6H2,(H,13,14)(H,15,16)" RELATED InChI [UPa:] synonym: "o-succinylbenzoate" EXACT [KEGG:KEGG] xref: CHEBI:18325 xref: CHEBI:44788 xref: KEGG:C02730 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02737 name: phosphatidylserine namespace: compound xref: CHEBI:11750 xref: CHEBI:18303 xref: KEGG:C02737 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02739 name: 1-(5-phospho-D-ribosyl)-ATP namespace: compound synonym: "C15H25N5O20P4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H25N5O20P4/c16-12-7-13(18-4-19(12)14-10(23)8(21)5(37-14)1-35-41(25,26)27)20(3-17-7)15-11(24)9(22)6(38-15)2-36-43(31,32)40-44(33,34)39-42(28,29)30/h3-6,8-11,14-16,21-24H,1-2H2,(H,31,32)(H,33,34)(H2,25,26,27)(H2,28,29,30)/t5-,6-,8-,9-,10-,11-,14-,15-/m1/s1" RELATED InChI [UPa:] synonym: "phosphoribosyl-ATP" EXACT [KEGG:KEGG] xref: CHEBI:73200 xref: KEGG:C02739 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02741 name: 1-(5-phosphoribosyl)-5'-AMP namespace: compound synonym: "C15H23N5O14P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H23N5O14P2/c16-12-7-13(18-4-19(12)14-10(23)8(21)5(33-14)1-31-35(25,26)27)20(3-17-7)15-11(24)9(22)6(34-15)2-32-36(28,29)30/h3-6,8-11,14-16,21-24H,1-2H2,(H2,25,26,27)(H2,28,29,30)/t5-,6-,8-,9-,10-,11-,14-,15-/m1/s1" RELATED InChI [UPa:] synonym: "phosphoribosyl-AMP" EXACT [KEGG:KEGG] xref: CHEBI:18374 xref: KEGG:C02741 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02814 name: benzene-1,2,4-triol namespace: compound synonym: "C6H6O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H6O3/c7-4-1-2-5(8)6(9)3-4/h1-3,7-9H" RELATED InChI [UPa:] xref: CHEBI:16971 xref: KEGG:C02814 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02876 name: propanoyl phosphate namespace: compound synonym: "C3H7O5P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7O5P/c1-2-3(4)8-9(5,6)7/h2H2,1H3,(H2,5,6,7)" RELATED InChI [UPa:] xref: CHEBI:8478 xref: KEGG:C02876 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02905 name: tRNA-queuosine namespace: compound xref: CHEBI:29188 xref: KEGG:C02905 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02923 name: 3-methylcatechol namespace: compound synonym: "C7H8O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H8O2/c1-5-3-2-4-6(8)7(5)9/h2-4,8-9H,1H3" RELATED InChI [UPa:] xref: CHEBI:18404 xref: KEGG:C02923 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02930 name: 2-methyleneglutarate namespace: compound synonym: "C6H8O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O4/c1-4(6(9)10)2-3-5(7)8/h1-3H2,(H,7,8)(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:17207 xref: KEGG:C02930 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02939 name: 3-isovaleryl-CoA namespace: compound synonym: "C26H44N7O17P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C26H44N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h12-15,19-21,25,36-37H,5-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/t15-,19-,20-,21+,25-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15487 xref: KEGG:C02939 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02949 name: 4-hydroxybenzoyl-CoA namespace: compound synonym: "C28H40N7O18P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20-,21-,22+,26-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15500 xref: KEGG:C02949 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC02987 name: L-glutamyl-tRNA(Glu) namespace: compound xref: CHEBI:29157 xref: KEGG:C02987 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03004 name: N-hydroxy-L-tyrosine namespace: compound synonym: "C9H11NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H11NO4/c11-7-3-1-6(2-4-7)5-8(10-14)9(12)13/h1-4,8,10-11,14H,5H2,(H,12,13)/t8-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:28089 xref: KEGG:C03004 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03043 name: (R)-6-hydroxynicotine namespace: compound synonym: "C10H14N2O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H14N2O/c1-12-6-2-3-9(12)8-4-5-10(13)11-7-8/h4-5,7,9H,2-3,6H2,1H3,(H,11,13)/t9-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18226 xref: KEGG:C03043 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03044 name: (R,R)-butane-2,3-diol namespace: compound synonym: "(R,R)-2,3-butanediol" EXACT [KEGG:KEGG] synonym: "C4H10O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H10O2/c1-3(5)4(2)6/h3-6H,1-2H3/t3-,4-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16982 xref: KEGG:C03044 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03056 name: 2,6-dihydroxypyridine namespace: compound synonym: "C5H5NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H5NO2/c7-4-2-1-3-5(8)6-4/h1-3H,(H2,6,7,8)" RELATED InChI [UPa:] xref: CHEBI:17681 xref: KEGG:C03056 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03058 name: 2-hydroxyglutaryl-CoA namespace: compound synonym: "C26H42N7O20P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C26H42N7O20P3S/c1-26(2,20(39)23(40)29-6-5-15(35)28-7-8-57-25(41)13(34)3-4-16(36)37)10-50-56(47,48)53-55(45,46)49-9-14-19(52-54(42,43)44)18(38)24(51-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-14,18-20,24,34,38-39H,3-10H2,1-2H3,(H,28,35)(H,29,40)(H,36,37)(H,45,46)(H,47,48)(H2,27,30,31)(H2,42,43,44)/t13?,14-,18-,19-,20+,24-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28578 xref: KEGG:C03058 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03069 name: 3-methylcrotonyl-CoA namespace: compound synonym: "C26H42N7O17P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/t15-,19-,20-,21+,25-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15486 xref: KEGG:C03069 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03082 name: 4-phospho-L-aspartate namespace: compound synonym: "C4H8NO7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H8NO7P/c5-2(4(7)8)1-3(6)12-13(9,10)11/h2H,1,5H2,(H,7,8)(H2,9,10,11)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15836 xref: KEGG:C03082 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03087 name: 5-acetamidopentanoate namespace: compound synonym: "C7H13NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H13NO3/c1-6(9)8-5-3-2-4-7(10)11/h2-5H2,1H3,(H,8,9)(H,10,11)" RELATED InChI [UPa:] xref: CHEBI:2024 xref: KEGG:C03087 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03089 name: 5-methylthio-alpha-D-ribose namespace: compound synonym: "5-methylthio-D-ribose" EXACT [KEGG:KEGG] synonym: "C6H12O4S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O4S/c1-11-2-3-4(7)5(8)6(9)10-3/h3-9H,2H2,1H3/t3-,4-,5-,6?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:78440 xref: KEGG:C03089 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03090 name: 5-phospho-beta-D-ribosylamine namespace: compound synonym: "C5H12NO7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H12NO7P/c6-5-4(8)3(7)2(13-5)1-12-14(9,10)11/h2-5,7-8H,1,6H2,(H2,9,10,11)/t2-,3-,4-,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:37737 xref: KEGG:C03090 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03114 name: 5,6-dimethylbenzimidazole namespace: compound synonym: "C9H10N2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H10N2/c1-6-3-8-9(4-7(6)2)11-5-10-8/h3-5H,1-2H3,(H,10,11)" RELATED InChI [UPa:] xref: CHEBI:15890 xref: KEGG:C03114 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03160 name: 2-succinylbenzoyl-CoA namespace: compound synonym: "C32H44N7O20P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C32H44N7O20P3S/c1-32(2,26(44)29(45)35-10-9-21(41)34-11-12-63-22(42)8-7-19(40)17-5-3-4-6-18(17)31(46)47)14-56-62(53,54)59-61(51,52)55-13-20-25(58-60(48,49)50)24(43)30(57-20)39-16-38-23-27(33)36-15-37-28(23)39/h3-6,15-16,20,24-26,30,43-44H,7-14H2,1-2H3,(H,34,41)(H,35,45)(H,46,47)(H,51,52)(H,53,54)(H2,33,36,37)(H2,48,49,50)/t20-,24-,25-,26+,30-/m1/s1" RELATED InChI [UPa:] synonym: "o-succinylbenzoyl-CoA" EXACT [KEGG:KEGG] xref: CHEBI:15509 xref: KEGG:C03160 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03175 name: 3-phosphoshikimate namespace: compound synonym: "C7H11O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H11O8P/c8-4-1-3(7(10)11)2-5(6(4)9)15-16(12,13)14/h2,4-6,8-9H,1H2,(H,10,11)(H2,12,13,14)/t4-,5-,6+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17052 xref: KEGG:C03175 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03194 name: (R)-1-aminopropan-2-ol namespace: compound synonym: "C3H9NO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3/t3-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15675 xref: KEGG:C03194 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03227 name: 3-hydroxy-L-kynurenine namespace: compound synonym: "C10H12N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17380 xref: KEGG:C03227 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03231 name: 3-methylglutaconyl-CoA namespace: compound synonym: "C27H42N7O19P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h9,12-13,15,20-22,26,39-40H,4-8,10-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/b14-9+/t15-,20-,21-,22+,26-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15488 xref: KEGG:C03231 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03232 name: 3-phosphohydroxypyruvate namespace: compound synonym: "C3H5O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)" RELATED InChI [UPa:] xref: CHEBI:18110 xref: CHEBI:30933 xref: KEGG:C03232 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03233 name: 4,5-dihydroxyphthalate namespace: compound synonym: "4,5-dihydroxyphthalic acid" EXACT [KEGG:KEGG] synonym: "C8H6O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H6O6/c9-5-1-3(7(11)12)4(8(13)14)2-6(5)10/h1-2,9-10H,(H,11,12)(H,13,14)" RELATED InChI [UPa:] xref: CHEBI:17199 xref: KEGG:C03233 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03263 name: coproporphyrinogen-III namespace: compound synonym: "C36H44N4O8" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-27-19(3)22(6-10-34(43)44)30(39-27)15-28-20(4)24(8-12-36(47)48)32(40-28)16-31-23(7-11-35(45)46)18(2)26(38-31)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48)" RELATED InChI [UPa:] xref: CHEBI:15439 xref: KEGG:C03263 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03273 name: 5-oxopentanoate namespace: compound synonym: "C5H8O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O3/c6-4-2-1-3-5(7)8/h4H,1-3H2,(H,7,8)" RELATED InChI [UPa:] xref: CHEBI:16120 xref: CHEBI:39153 xref: KEGG:C03273 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03283 name: L-2,4-diaminobutanoate namespace: compound synonym: "C4H10N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H10N2O2/c5-2-1-3(6)4(7)8/h3H,1-2,5-6H2,(H,7,8)/t3-/m0/s1" RELATED InChI [UPa:] synonym: "L-2,4-diaminobutyrate" EXACT [KEGG:KEGG] xref: CHEBI:48950 xref: KEGG:C03283 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03287 name: L-glutamyl 5-phosphate namespace: compound synonym: "C5H10NO7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10NO7P/c6-3(5(8)9)1-2-4(7)13-14(10,11)12/h3H,1-2,6H2,(H,8,9)(H2,10,11,12)/t3-/m0/s1" RELATED InChI [UPa:] synonym: "L-glutamate 5-phosphate" EXACT [KEGG:KEGG] xref: CHEBI:17798 xref: KEGG:C03287 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03289 name: L-xylo-hexulonolactone namespace: compound synonym: "C6H8O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-3,5,7-9H,1H2/t2-,3+,5+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:73681 xref: KEGG:C03289 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03291 name: L-xylulose 5-phosphate namespace: compound synonym: "C5H11O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/t4-,5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16593 xref: KEGG:C03291 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03296 name: N(2)-succinyl-L-arginine namespace: compound synonym: "C10H18N4O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H18N4O5/c11-10(12)13-5-1-2-6(9(18)19)14-7(15)3-4-8(16)17/h6H,1-5H2,(H,14,15)(H,16,17)(H,18,19)(H4,11,12,13)/t6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17705 xref: KEGG:C03296 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03319 name: dTDP-L-rhamnose namespace: compound synonym: "C16H26N2O15P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C16H26N2O15P2/c1-6-4-18(16(24)17-14(6)23)10-3-8(19)9(31-10)5-29-34(25,26)33-35(27,28)32-15-13(22)12(21)11(20)7(2)30-15/h4,7-13,15,19-22H,3,5H2,1-2H3,(H,25,26)(H,27,28)(H,17,23,24)/t7-,8-,9+,10+,11-,12+,13+,15+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15774 xref: KEGG:C03319 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03340 name: (S)-2,3-dihydrodipicolinate namespace: compound synonym: "2,3-dihydrodipicolinate" EXACT [KEGG:KEGG] synonym: "C7H7NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H7NO4/c9-6(10)4-2-1-3-5(8-4)7(11)12/h1-2,5H,3H2,(H,9,10)(H,11,12)/t5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18042 xref: CHEBI:30620 xref: KEGG:C03340 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03373 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole namespace: compound synonym: "C8H14N3O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H14N3O7P/c9-5-1-10-3-11(5)8-7(13)6(12)4(18-8)2-17-19(14,15)16/h1,3-4,6-8,12-13H,2,9H2,(H2,14,15,16)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28843 xref: KEGG:C03373 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03393 name: 4-phospho-D-erythronate namespace: compound synonym: "C4H9O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H9O8P/c5-2(3(6)4(7)8)1-12-13(9,10)11/h2-3,5-6H,1H2,(H,7,8)(H2,9,10,11)/t2-,3-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:49003 xref: KEGG:C03393 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03406 name: (N(omega)-L-arginino)succinate namespace: compound synonym: "C10H18N4O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H18N4O6/c11-5(8(17)18)2-1-3-13-10(12)14-6(9(19)20)4-7(15)16/h5-6H,1-4,11H2,(H,15,16)(H,17,18)(H,19,20)(H3,12,13,14)/t5-,6-/m0/s1" RELATED InChI [UPa:] synonym: "N(omega)-(L-arginino)succinic acid" EXACT [KEGG:KEGG] xref: CHEBI:15682 xref: KEGG:C03406 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03415 name: N(2)-succinyl-L-ornithine namespace: compound synonym: "C9H16N2O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H16N2O5/c10-5-1-2-6(9(15)16)11-7(12)3-4-8(13)14/h6H,1-5,10H2,(H,11,12)(H,13,14)(H,15,16)/t6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:27574 xref: KEGG:C03415 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03427 name: prephytoene diphosphate namespace: compound synonym: "C40H68O7P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H68O7P2/c1-31(2)17-11-19-33(5)21-13-23-35(7)25-15-26-37(9)29-38-39(30-46-49(44,45)47-48(41,42)43)40(38,10)28-16-27-36(8)24-14-22-34(6)20-12-18-32(3)4/h17-18,21-22,25,27,29,38-39H,11-16,19-20,23-24,26,28,30H2,1-10H3,(H,44,45)(H2,41,42,43)/b33-21+,34-22+,35-25+,36-27+,37-29+/t38-,39-,40-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17090 xref: KEGG:C03427 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03428 name: presqualene diphosphate namespace: compound synonym: "C30H52O7P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/b25-17+,26-19+,27-21+/t28-,29-,30-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15442 xref: KEGG:C03428 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03438 name: beta-lactam namespace: compound xref: CHEBI:27933 xref: KEGG:C03438 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03451 name: (R)-S-lactoylglutathione namespace: compound synonym: "C13H21N3O8S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/t6-,7+,8+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15694 xref: KEGG:C03451 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03459 name: 2-hydroxy-3-oxosuccinate namespace: compound synonym: "2-hydroxy-3-oxosuccinic acid" EXACT [KEGG:KEGG] synonym: "C4H4O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H4O6/c5-1(3(7)8)2(6)4(9)10/h1,5H,(H,7,8)(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:17778 xref: KEGG:C03459 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03470 name: 3alpha(S)-strictosidine namespace: compound synonym: "3-alpha-(S)-strictosidine" EXACT [KEGG:KEGG] synonym: "C27H34N2O9" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C27H34N2O9/c1-3-13-16(10-19-21-15(8-9-28-19)14-6-4-5-7-18(14)29-21)17(25(34)35-2)12-36-26(13)38-27-24(33)23(32)22(31)20(11-30)37-27/h3-7,12-13,16,19-20,22-24,26-33H,1,8-11H2,2H3/t13-,16+,19+,20-,22-,23+,24-,26+,27+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17559 xref: KEGG:C03470 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03492 name: (R)-4'-phosphopantothenate namespace: compound synonym: "C9H18NO8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H18NO8P/c1-9(2,5-18-19(15,16)17)7(13)8(14)10-4-3-6(11)12/h7,13H,3-5H2,1-2H3,(H,10,14)(H,11,12)(H2,15,16,17)/t7-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15905 xref: KEGG:C03492 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03506 name: indoleglycerol phosphate namespace: compound synonym: "C11H14NO6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H14NO6P/c13-10(6-18-19(15,16)17)11(14)8-5-12-9-4-2-1-3-7(8)9/h1-5,10-14H,6H2,(H2,15,16,17)/t10-,11+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18299 xref: CHEBI:51793 xref: KEGG:C03506 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03508 name: L-2-amino-3-oxobutanoic acid namespace: compound synonym: "C4H7NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H7NO3/c1-2(6)3(5)4(7)8/h3H,5H2,1H3,(H,7,8)/t3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16944 xref: CHEBI:40673 xref: KEGG:C03508 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03569 name: biphenyl-2,2',3-triol namespace: compound synonym: "2,2',3-trihydroxybiphenyl" EXACT [KEGG:KEGG] synonym: "C12H10O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H10O3/c13-10-6-2-1-4-8(10)9-5-3-7-11(14)12(9)15/h1-7,13-15H" RELATED InChI [UPa:] xref: CHEBI:28517 xref: KEGG:C03569 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03576 name: coenzyme M namespace: compound synonym: "C2H6O3S2" RELATED FORMULA [KEGG:COMPOUND] synonym: "HS-CoM" EXACT [KEGG:KEGG] synonym: "InChI=1S/C2H6O3S2/c3-7(4,5)2-1-6/h6H,1-2H2,(H,3,4,5)" RELATED InChI [UPa:] xref: CHEBI:17905 xref: KEGG:C03576 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03582 name: 3,4',5-trihydroxystilbene namespace: compound synonym: "C14H12O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+" RELATED InChI [UPa:] xref: CHEBI:27881 xref: CHEBI:45713 xref: KEGG:C03582 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03586 name: 5-oxo-4,5-dihydro-2-furylacetate namespace: compound synonym: "5-oxo-4,5-dihydrofuran-2-acetate" EXACT [KEGG:KEGG] synonym: "C6H6O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H6O4/c7-5(8)3-4-1-2-6(9)10-4/h1H,2-3H2,(H,7,8)" RELATED InChI [UPa:] xref: CHEBI:18267 xref: KEGG:C03586 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03589 name: 4-hydroxy-2-oxopentanoate namespace: compound synonym: "4-hydroxy-2-oxopentanoic acid" EXACT [KEGG:KEGG] synonym: "C5H8O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O4/c1-3(6)2-4(7)5(8)9/h3,6H,2H2,1H3,(H,8,9)" RELATED InChI [UPa:] xref: CHEBI:17655 xref: KEGG:C03589 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03598 name: CDP-3,6-dideoxy-D-glucose namespace: compound synonym: "C15H25N3O14P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H25N3O14P2/c1-6-7(19)4-8(20)14(29-6)31-34(26,27)32-33(24,25)28-5-9-11(21)12(22)13(30-9)18-3-2-10(16)17-15(18)23/h2-3,6-9,11-14,19-22H,4-5H2,1H3,(H,24,25)(H,26,27)(H2,16,17,23)/t6-,7+,8-,9-,11-,12-,13-,14-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:70802 xref: KEGG:C03598 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03599 name: CDP-3,6-dideoxy-D-mannose namespace: compound synonym: "C15H25N3O14P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H25N3O14P2/c1-6-7(19)4-8(20)14(29-6)31-34(26,27)32-33(24,25)28-5-9-11(21)12(22)13(30-9)18-3-2-10(16)17-15(18)23/h2-3,6-9,11-14,19-22H,4-5H2,1H3,(H,24,25)(H,26,27)(H2,16,17,23)/t6-,7+,8+,9-,11-,12-,13-,14-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17259 xref: KEGG:C03599 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03618 name: (2S,3S)-3-methyl-L-aspartate namespace: compound synonym: "C5H9NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H9NO4/c1-2(4(7)8)3(6)5(9)10/h2-3H,6H2,1H3,(H,7,8)(H,9,10)/t2-,3-/m0/s1" RELATED InChI [UPa:] synonym: "threo-3-methyl-L-aspartic acid" EXACT [KEGG:KEGG] xref: CHEBI:47980 xref: KEGG:C03618 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03652 name: (2R,3S)-2,3-dimethylmalate namespace: compound synonym: "C6H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O5/c1-3(4(7)8)6(2,11)5(9)10/h3,11H,1-2H3,(H,7,8)(H,9,10)/t3-,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15582 xref: KEGG:C03652 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03657 name: 1,4-dihydroxy-2-naphthoate namespace: compound synonym: "C11H8O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H8O4/c12-9-5-8(11(14)15)10(13)7-4-2-1-3-6(7)9/h1-5,12-13H,(H,14,15)" RELATED InChI [UPa:] xref: CHEBI:18094 xref: KEGG:C03657 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03664 name: (2,4-dichlorophenoxy)acetate namespace: compound synonym: "C8H6Cl2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H6Cl2O3/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2,(H,11,12)" RELATED InChI [UPa:] xref: CHEBI:28854 xref: KEGG:C03664 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03676 name: 3-hydroxy-cis,cis-muconate namespace: compound synonym: "C6H6O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H6O5/c7-4(3-6(10)11)1-2-5(8)9/h1-3,7H,(H,8,9)(H,10,11)/b2-1-,4-3+" RELATED InChI [UPa:] xref: CHEBI:17419 xref: KEGG:C03676 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03680 name: 4-imidazolone-5-propanoate namespace: compound synonym: "4-imidazolone-5-acetic acid" EXACT [KEGG:KEGG] synonym: "C6H8N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8N2O3/c9-5(10)2-1-4-6(11)8-3-7-4/h3-4H,1-2H2,(H,9,10)(H,7,8,11)" RELATED InChI [UPa:] xref: CHEBI:27384 xref: KEGG:C03680 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03684 name: 6-pyruvoyl-tetrahydropterin namespace: compound synonym: "6-pyruvoyltetrahydropterin" EXACT [KEGG:KEGG] synonym: "C9H11N5O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h4,12H,2H2,1H3,(H4,10,11,13,14,17)" RELATED InChI [UPa:] xref: CHEBI:17804 xref: KEGG:C03684 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03722 name: quinolinate namespace: compound synonym: "C7H5NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)" RELATED InChI [UPa:] synonym: "pyridine-2,3-dicarboxylate" EXACT [KEGG:KEGG] xref: CHEBI:16675 xref: KEGG:C03722 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03741 name: (S)-4-amino-5-oxopentanoic acid namespace: compound synonym: "C5H9NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H9NO3/c6-4(3-7)1-2-5(8)9/h3-4H,1-2,6H2,(H,8,9)/t4-/m0/s1" RELATED InChI [UPa:] synonym: "L-glutamate 1-semialdehyde" EXACT [KEGG:KEGG] xref: CHEBI:15757 xref: KEGG:C03741 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03742 name: (S)-4-hydroxymandelonitrile namespace: compound synonym: "C8H7NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H7NO2/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4,8,10-11H/t8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16660 xref: KEGG:C03742 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03758 name: dopamine namespace: compound synonym: "C8H11NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2" RELATED InChI [UPa:] xref: CHEBI:18243 xref: KEGG:C03758 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03785 name: D-tagatose 1,6-bisphosphate namespace: compound synonym: "C6H14O12P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/t3-,4+,5+,6?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:4250 xref: KEGG:C03785 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03794 name: N(6)-(1,2-dicarboxyethyl)-AMP namespace: compound synonym: "C14H18N5O11P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H18N5O11P/c20-7(21)1-5(14(24)25)18-11-8-12(16-3-15-11)19(4-17-8)13-10(23)9(22)6(30-13)2-29-31(26,27)28/h3-6,9-10,13,22-23H,1-2H2,(H,20,21)(H,24,25)(H,15,16,18)(H2,26,27,28)/t5-,6+,9+,10+,13+/m0/s1" RELATED InChI [UPa:] synonym: "N(6)-(1,2-dicarboxyethyl)AMP" EXACT [KEGG:KEGG] xref: CHEBI:15919 xref: KEGG:C03794 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03838 name: N(1)-(5-phospho-D-ribosyl)glycinamide namespace: compound synonym: "C7H15N2O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H15N2O8P/c8-1-4(10)9-7-6(12)5(11)3(17-7)2-16-18(13,14)15/h3,5-7,11-12H,1-2,8H2,(H,9,10)(H2,13,14,15)/t3-,5-,6-,7-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18349 xref: KEGG:C03838 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03871 name: (S)-2-amino-6-oxopimelate namespace: compound synonym: "2-amino-6-oxopimelate" EXACT [KEGG:KEGG] synonym: "C7H11NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H11NO5/c8-4(6(10)11)2-1-3-5(9)7(12)13/h4H,1-3,8H2,(H,10,11)(H,12,13)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:28245 xref: KEGG:C03871 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03892 name: phosphatidylglycerophosphate namespace: compound xref: CHEBI:37393 xref: KEGG:C03892 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03912 name: (S)-1-pyrroline-5-carboxylic acid namespace: compound synonym: "1-pyrroline-5-carboxylate" EXACT [KEGG:KEGG] synonym: "C5H7NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H7NO2/c7-5(8)4-2-1-3-6-4/h3-4H,1-2H2,(H,7,8)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17388 xref: CHEBI:371 xref: KEGG:C03912 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03920 name: methyl-coenzyme M namespace: compound synonym: "C3H8O3S2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H8O3S2/c1-7-2-3-8(4,5)6/h2-3H2,1H3,(H,4,5,6)" RELATED InChI [UPa:] synonym: "methyl-CoM" EXACT [KEGG:KEGG] xref: CHEBI:17827 xref: KEGG:C03920 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC03972 name: (S)-tetrahydrodipicolinate namespace: compound synonym: "C7H9NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H9NO4/c9-6(10)4-2-1-3-5(8-4)7(11)12/h4H,1-3H2,(H,9,10)(H,11,12)/t4-/m0/s1" RELATED InChI [UPa:] synonym: "tetrahydrodipicolinate" EXACT [KEGG:KEGG] xref: CHEBI:16845 xref: CHEBI:864 xref: KEGG:C03972 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04002 name: homo-cis-aconitate namespace: compound synonym: "C7H8O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H8O6/c8-5(9)2-1-4(7(12)13)3-6(10)11/h3H,1-2H2,(H,8,9)(H,10,11)(H,12,13)/b4-3-" RELATED InChI [UPa:] xref: CHEBI:17516 xref: KEGG:C04002 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04006 name: 1D-myo-inositol 3-phosphate namespace: compound synonym: "C6H13O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/t1-,2-,3+,4-,5-,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18169 xref: KEGG:C04006 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04021 name: phosphatidylinositol phosphate namespace: compound xref: KEGG:C04021 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04044 name: 3-(2,3-dihydroxyphenyl)propanoate namespace: compound synonym: "3-(2,3-dihydroxyphenyl)propionic acid" EXACT [KEGG:KEGG] synonym: "C9H10O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H10O4/c10-7-3-1-2-6(9(7)13)4-5-8(11)12/h1-3,10,13H,4-5H2,(H,11,12)" RELATED InChI [UPa:] xref: CHEBI:18136 xref: CHEBI:46951 xref: KEGG:C04044 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04052 name: 5-oxopent-3-ene-1,2,5-tricarboxylic acid namespace: compound synonym: "5-carboxy-2-oxohept-3-enedioate" EXACT [KEGG:KEGG] synonym: "C8H8O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H8O7/c9-5(8(14)15)2-1-4(7(12)13)3-6(10)11/h1-2,4H,3H2,(H,10,11)(H,12,13)(H,14,15)/b2-1-" RELATED InChI [UPa:] xref: CHEBI:15924 xref: KEGG:C04052 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04053 name: 5-dehydro-4-deoxy-D-glucuronic acid namespace: compound synonym: "5-dehydro-4-deoxy-D-glucuronate" EXACT [KEGG:KEGG] synonym: "C6H8O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O6/c7-2-5(10)3(8)1-4(9)6(11)12/h2-3,5,8,10H,1H2,(H,11,12)/t3-,5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17117 xref: CHEBI:17782 xref: KEGG:C04053 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04076 name: L-2-aminoadipate 6-semialdahyde namespace: compound synonym: "alpha-aminoadipate 6-semialdehyde" EXACT [KEGG:KEGG] synonym: "C6H11NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17917 xref: KEGG:C04076 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04091 name: cis-1,2-dihydrobenzene-1,2-diol namespace: compound synonym: "C6H8O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O2/c7-5-3-1-2-4-6(5)8/h1-8H/t5-,6+" RELATED InChI [UPa:] xref: CHEBI:16190 xref: KEGG:C04091 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04121 name: CMP-3-deoxy-D-manno-octulosonate namespace: compound synonym: "C17H26N3O15P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C17H26N3O15P/c18-9-1-2-20(16(29)19-9)14-12(26)11(25)8(33-14)5-32-36(30,31)35-17(15(27)28)3-6(22)10(24)13(34-17)7(23)4-21/h1-2,6-8,10-14,21-26H,3-5H2,(H,27,28)(H,30,31)(H2,18,19,29)/t6-,7-,8-,10-,11-,12-,13-,14-,17-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18014 xref: KEGG:C04121 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04133 name: N-acetyl-L-glutamyl 5-phosphate namespace: compound synonym: "C7H12NO8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H12NO8P/c1-4(9)8-5(7(11)12)2-3-6(10)16-17(13,14)15/h5H,2-3H2,1H3,(H,8,9)(H,11,12)(H2,13,14,15)/t5-/m0/s1" RELATED InChI [UPa:] synonym: "N-acetyl-L-glutamate 5-phosphate" EXACT [KEGG:KEGG] xref: CHEBI:16878 xref: KEGG:C04133 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04144 name: tetrahydropteroyltri-L-glutamate namespace: compound synonym: "C29H37N9O12" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C29H37N9O12/c30-29-37-23-22(25(44)38-29)33-15(12-32-23)11-31-14-3-1-13(2-4-14)24(43)36-18(28(49)50)6-9-20(40)34-16(26(45)46)5-8-19(39)35-17(27(47)48)7-10-21(41)42/h1-4,15-18,31,33H,5-12H2,(H,34,40)(H,35,39)(H,36,43)(H,41,42)(H,45,46)(H,47,48)(H,49,50)(H4,30,32,37,38,44)/t15-,16-,17-,18-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17420 xref: KEGG:C04144 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04146 name: all-trans-octaprenyl diphosphate namespace: compound synonym: "C40H68O7P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H68O7P2/c1-33(2)17-10-18-34(3)19-11-20-35(4)21-12-22-36(5)23-13-24-37(6)25-14-26-38(7)27-15-28-39(8)29-16-30-40(9)31-32-46-49(44,45)47-48(41,42)43/h17,19,21,23,25,27,29,31H,10-16,18,20,22,24,26,28,30,32H2,1-9H3,(H,44,45)(H2,41,42,43)/b34-19+,35-21+,36-23+,37-25+,38-27+,39-29+,40-31+" RELATED InChI [UPa:] xref: CHEBI:16275 xref: KEGG:C04146 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04181 name: 2-oxo-3-hydroxyisovalerate namespace: compound synonym: "C5H8O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O4/c1-5(2,9)3(6)4(7)8/h9H,1-2H3,(H,7,8)" RELATED InChI [UPa:] xref: CHEBI:11812 xref: CHEBI:17667 xref: KEGG:C04181 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04186 name: 5-carboxymethyl-2-hydroxymuconic acid namespace: compound synonym: "5-carboxymethyl-2-hydroxymuconate" EXACT [KEGG:KEGG] synonym: "C8H8O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H8O7/c9-5(8(14)15)2-1-4(7(12)13)3-6(10)11/h1-2,9H,3H2,(H,10,11)(H,12,13)(H,14,15)/b4-1-,5-2+" RELATED InChI [UPa:] xref: CHEBI:2040 xref: KEGG:C04186 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04188 name: S-methyl-5-thio-alpha-D-ribose 1-phosphate namespace: compound synonym: "(S)-methyl-5-thio-alpha-D-ribose 1-phosphate" EXACT [KEGG:KEGG] synonym: "C6H13O7PS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O7PS/c1-15-2-3-4(7)5(8)6(12-3)13-14(9,10)11/h3-8H,2H2,1H3,(H2,9,10,11)/t3-,4-,5-,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27859 xref: KEGG:C04188 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04226 name: 6-hydroxynicotinate namespace: compound synonym: "C6H7NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H7NO3/c8-5-2-1-4(3-7-5)6(9)10/h3H,1-2H2,(H,7,8)(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:16453 xref: KEGG:C04226 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04236 name: 3-carboxy-4-methyl-2-oxopentanoate namespace: compound synonym: "C7H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H10O5/c1-3(2)4(6(9)10)5(8)7(11)12/h3-4H,1-2H3,(H,9,10)(H,11,12)/t4-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:1467 xref: KEGG:C04236 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04244 name: 6-lactoyl-5,6,7,8-tetrahydropterin namespace: compound synonym: "C9H13N5O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,12,15H,2H2,1H3,(H4,10,11,13,14,17)" RELATED InChI [UPa:] xref: CHEBI:17248 xref: KEGG:C04244 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04253 name: electron-transferring flavoprotein namespace: compound xref: KEGG:C04253 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04256 name: N-acetyl-D-glucosamine 1-phosphate namespace: compound synonym: "C8H16NO9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:7125 xref: KEGG:C04256 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04257 name: N-acetyl-D-mannosamine 6-phosphate namespace: compound synonym: "C8H16NO9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/t4-,5+,6-,7-,8?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28273 xref: CHEBI:62168 xref: KEGG:C04257 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04261 name: protein N(pi)-phospho-L-histidine namespace: compound xref: KEGG:C04261 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04272 name: (R)-2,3-dihydroxy-3-methylbutanoate namespace: compound synonym: "(R)-2,3-Dihydroxy-3-methylbutanoate" EXACT [KEGG:KEGG] synonym: "(R)-2,3-dihydroxy-3-methylbutanoic acid" EXACT [KEGG:KEGG] synonym: "C5H10O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10O4/c1-5(2,9)3(6)4(7)8/h3,6,9H,1-2H3,(H,7,8)/t3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15684 xref: CHEBI:49072 xref: KEGG:C04272 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04287 name: 3D-3,5/4-trihydroxycyclohexane-1,2-dione namespace: compound synonym: "C6H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O5/c7-2-1-3(8)5(10)6(11)4(2)9/h2,4,6-7,9,11H,1H2/t2-,4+,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16145 xref: CHEBI:28446 xref: KEGG:C04287 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04294 name: 5-(2-hydroxyethyl)-4-methylthiazole namespace: compound synonym: "4-methyl-5-(2-hydroxyethyl)-thiazole" EXACT [KEGG:KEGG] synonym: "C6H9NOS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H9NOS/c1-5-6(2-3-8)9-4-7-5/h4,8H,2-3H2,1H3" RELATED InChI [UPa:] xref: CHEBI:17957 xref: KEGG:C04294 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04297 name: CDP-4-dehydro-3,6-dideoxy-D-glucose namespace: compound synonym: "C15H23N3O14P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H23N3O14P2/c1-6-7(19)4-8(20)14(29-6)31-34(26,27)32-33(24,25)28-5-9-11(21)12(22)13(30-9)18-3-2-10(16)17-15(18)23/h2-3,6,8-9,11-14,20-22H,4-5H2,1H3,(H,24,25)(H,26,27)(H2,16,17,23)/t6-,8-,9-,11-,12-,13-,14-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:70800 xref: KEGG:C04297 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04302 name: N-(5-phospho-beta-D-ribosyl)anthranilic acid namespace: compound synonym: "C12H16NO9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H16NO9P/c14-9-8(5-21-23(18,19)20)22-11(10(9)15)13-7-4-2-1-3-6(7)12(16)17/h1-4,8-11,13-15H,5H2,(H,16,17)(H2,18,19,20)/t8-,9-,10-,11-/m1/s1" RELATED InChI [UPa:] synonym: "N-(5-phospho-ribosyl) anthranilate" EXACT [KEGG:KEGG] xref: CHEBI:18277 xref: CHEBI:7091 xref: KEGG:C04302 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04327 name: 4-methyl-5-(2-phosphoethyl)-thiazole namespace: compound synonym: "C6H10NO4PS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10NO4PS/c1-5-6(13-4-7-5)2-3-11-12(8,9)10/h4H,2-3H2,1H3,(H2,8,9,10)" RELATED InChI [UPa:] xref: CHEBI:17857 xref: KEGG:C04327 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04330 name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin namespace: compound synonym: "5,10-methenyl-H(4)MPT" EXACT [KEGG:KEGG] synonym: "5,10-methenyl-THMPT" EXACT [KEGG:KEGG] synonym: "C31H44N6O16P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C31H43N6O16P/c1-13-22-14(2)36(12-37(22)23-27(33-13)34-31(32)35-28(23)45)16-5-3-15(4-6-16)9-17(38)24(42)18(39)10-50-30-26(44)25(43)20(52-30)11-51-54(48,49)53-19(29(46)47)7-8-21(40)41/h3-6,12-14,17-20,22,24-26,30,38-39,42-44H,7-11H2,1-2H3,(H6-,32,33,34,35,40,41,45,46,47,48,49)/p+1/t13-,14+,17-,18+,19-,20+,22+,24-,25+,26+,30-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17975 xref: KEGG:C04330 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04332 name: 6,7-dimethyl-8-(1-D-ribityl)lumazine namespace: compound synonym: "4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine" EXACT [KEGG:KEGG] synonym: "C13H18N4O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C13H18N4O6/c1-5-6(2)17(3-7(19)10(21)8(20)4-18)11-9(14-5)12(22)16-13(23)15-11/h7-8,10,18-21H,3-4H2,1-2H3,(H,16,22,23)/t7-,8+,10-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17601 xref: KEGG:C04332 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04349 name: 3-deoxy-D-glycero-hexo-2,5-diulosonate namespace: compound synonym: "(4S)-4,6-dihydroxy-2,5-dioxohexanoate" EXACT [KEGG:KEGG] synonym: "C6H8O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O6/c7-2-5(10)3(8)1-4(9)6(11)12/h3,7-8H,1-2H2,(H,11,12)/t3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15623 xref: KEGG:C04349 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04352 name: N-[(R)-4-phosphonopantothenoyl]-L-cysteine namespace: compound synonym: "C12H23N2O9PS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/t7-,9-/m0/s1" RELATED InChI [UPa:] synonym: "N-((R)-4'-phosphopantothenoyl)-L-cysteine" EXACT [KEGG:KEGG] xref: CHEBI:15769 xref: KEGG:C04352 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04353 name: (Z)-(4-hydroxyphenyl)acetaldehyde oxime namespace: compound synonym: "C8H9NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H9NO2/c10-8-3-1-7(2-4-8)5-6-9-11/h1-4,6,10-11H,5H2/b9-6-" RELATED InChI [UPa:] xref: CHEBI:15667 xref: KEGG:C04353 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04376 name: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide namespace: compound synonym: "C8H15N2O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H15N2O9P/c11-3-9-1-5(12)10-8-7(14)6(13)4(19-8)2-18-20(15,16)17/h3-4,6-8,13-14H,1-2H2,(H,9,11)(H,10,12)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18272 xref: CHEBI:42411 xref: KEGG:C04376 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04377 name: 5,10-methylene-5,6,7,8-tetrahydromethanopterin namespace: compound synonym: "5,10-methylene-H(4)MPT" EXACT [KEGG:KEGG] synonym: "5,10-methylene-THMPT" EXACT [KEGG:KEGG] synonym: "C31H45N6O16P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C31H45N6O16P/c1-13-22-14(2)36(12-37(22)23-27(33-13)34-31(32)35-28(23)45)16-5-3-15(4-6-16)9-17(38)24(42)18(39)10-50-30-26(44)25(43)20(52-30)11-51-54(48,49)53-19(29(46)47)7-8-21(40)41/h3-6,13-14,17-20,22,24-26,30,38-39,42-44H,7-12H2,1-2H3,(H,40,41)(H,46,47)(H,48,49)(H4,32,33,34,35,45)/t13-,14+,17-,18+,19-,20+,22+,24-,25+,26+,30-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16568 xref: KEGG:C04377 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04390 name: N-acetyl-LL-2,6-diaminopimelate namespace: compound synonym: "C9H16N2O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H16N2O5/c1-5(12)11-7(9(15)16)4-2-3-6(10)8(13)14/h6-7H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t6-,7-/m0/s1" RELATED InChI [UPa:] synonym: "N-acetyl 2,6-diaminopimelate" EXACT [KEGG:KEGG] xref: CHEBI:18317 xref: CHEBI:49004 xref: KEGG:C04390 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04409 name: 2-amino-3-carboxymuconate semialdehyde namespace: compound synonym: "C7H7NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H7NO5/c8-5(7(12)13)4(6(10)11)2-1-3-9/h1-3H,8H2,(H,10,11)(H,12,13)/b2-1-,5-4-" RELATED InChI [UPa:] xref: CHEBI:995 xref: KEGG:C04409 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04411 name: (2R,3S)-3-isopropylmalate namespace: compound synonym: "3-isopropylmalate" EXACT [KEGG:KEGG] synonym: "C7H12O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H12O5/c1-3(2)4(6(9)10)5(8)7(11)12/h3-5,8H,1-2H3,(H,9,10)(H,11,12)/t4-,5+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:35121 xref: CHEBI:43468 xref: KEGG:C04411 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04421 name: N-succinyl-LL-2,6-diaminopimelate namespace: compound synonym: "C11H18N2O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H18N2O7/c12-6(10(17)18)2-1-3-7(11(19)20)13-8(14)4-5-9(15)16/h6-7H,1-5,12H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)/t6-,7-/m0/s1" RELATED InChI [UPa:] synonym: "N-succinyl 2,6-diaminopimelate" EXACT [KEGG:KEGG] xref: CHEBI:17279 xref: KEGG:C04421 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04425 name: S-adenosyl-4-methylthio-2-oxobutanoic acid namespace: compound synonym: "C15H20N5O6S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H19N5O6S/c1-27(3-2-7(21)15(24)25)4-8-10(22)11(23)14(26-8)20-6-19-9-12(16)17-5-18-13(9)20/h5-6,8,10-11,14,22-23H,2-4H2,1H3,(H2-,16,17,18,24,25)/p+1/t8-,10-,11-,14-,27?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:8944 xref: KEGG:C04425 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04442 name: 2-dehydro-3-deoxy-6-phospho-D-gluconic acid namespace: compound synonym: "2-dehydro-3-deoxy-6-phospho-D-gluconate" EXACT [KEGG:KEGG] synonym: "C6H11O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H11O9P/c7-3(1-4(8)6(10)11)5(9)2-15-16(12,13)14/h3,5,7,9H,1-2H2,(H,10,11)(H2,12,13,14)/t3-,5+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15925 xref: KEGG:C04442 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04454 name: 5-amino-6-(5-phosphoribitylamino)uracil namespace: compound synonym: "4-(1-D-ribitylamino)-5-aminouracil" EXACT [KEGG:KEGG] synonym: "C9H17N4O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H17N4O9P/c10-5-7(12-9(18)13-8(5)17)11-1-3(14)6(16)4(15)2-22-23(19,20)21/h3-4,6,14-16H,1-2,10H2,(H2,19,20,21)(H3,11,12,13,17,18)/t3-,4+,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18247 xref: KEGG:C04454 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04462 name: L-2-succinylamino-6-oxopimelate namespace: compound synonym: "C11H15NO8" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H15NO8/c13-7(11(19)20)3-1-2-6(10(17)18)12-8(14)4-5-9(15)16/h6H,1-5H2,(H,12,14)(H,15,16)(H,17,18)(H,19,20)/t6-/m0/s1" RELATED InChI [UPa:] synonym: "N-succinyl amino-6-oxopimelate" EXACT [KEGG:KEGG] xref: CHEBI:15685 xref: CHEBI:35266 xref: KEGG:C04462 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04478 name: 8-phospho-3-deoxy-D-manno-octulosonate namespace: compound synonym: "3-deoxy-D-manno-octulosonate 8-phosphate" EXACT [KEGG:KEGG] synonym: "C8H15O11P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H15O11P/c9-3(1-4(10)8(14)15)6(12)7(13)5(11)2-19-20(16,17)18/h3,5-7,9,11-13H,1-2H2,(H,14,15)(H2,16,17,18)/t3-,5-,6-,7-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18069 xref: KEGG:C04478 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04479 name: 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate namespace: compound synonym: "2-hydroxy-6-oxonona-2,4-dienedioic acid" EXACT [KEGG:KEGG] synonym: "C9H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H10O6/c10-6(4-5-8(12)13)2-1-3-7(11)9(14)15/h1-3,11H,4-5H2,(H,12,13)(H,14,15)/b2-1-,7-3+" RELATED InChI [UPa:] xref: CHEBI:17367 xref: CHEBI:61470 xref: KEGG:C04479 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04488 name: 5-methyl-5,6,7,8-tetrahydromethanopterin namespace: compound synonym: "C31H47N6O16P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C31H47N6O16P/c1-13(22-14(2)34-27-23(37(22)3)28(45)36-31(32)35-27)33-16-6-4-15(5-7-16)10-17(38)24(42)18(39)11-50-30-26(44)25(43)20(52-30)12-51-54(48,49)53-19(29(46)47)8-9-21(40)41/h4-7,13-14,17-20,22,24-26,30,33,38-39,42-44H,8-12H2,1-3H3,(H,40,41)(H,46,47)(H,48,49)(H4,32,34,35,36,45)/t13-,14+,17+,18-,19+,20-,22+,24+,25-,26-,30+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17349 xref: KEGG:C04488 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04489 name: 5-methyltetrahydropteroyltri-L-glutamate namespace: compound synonym: "C30H39N9O12" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C30H39N9O12/c1-39-16(13-33-24-23(39)26(45)38-30(31)37-24)12-32-15-4-2-14(3-5-15)25(44)36-19(29(50)51)7-10-21(41)34-17(27(46)47)6-9-20(40)35-18(28(48)49)8-11-22(42)43/h2-5,16-19,32H,6-13H2,1H3,(H,34,41)(H,35,40)(H,36,44)(H,42,43)(H,46,47)(H,48,49)(H,50,51)(H4,31,33,37,38,45)/t16-,17-,18-,19-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17614 xref: KEGG:C04489 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04494 name: guanosine 3'-diphosphate 5'-triphosphate namespace: compound synonym: "C10H18N5O20P5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H18N5O20P5/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6(32-39(26,27)33-36(18,19)20)3(31-9)1-30-38(24,25)35-40(28,29)34-37(21,22)23/h2-3,5-6,9,16H,1H2,(H,24,25)(H,26,27)(H,28,29)(H2,18,19,20)(H2,21,22,23)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1" RELATED InChI [UPa:] synonym: "pppGpp" EXACT [KEGG:KEGG] xref: CHEBI:16690 xref: KEGG:C04494 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04501 name: N-acetyl-alpha-D-glucosamine 1-phosphate namespace: compound synonym: "C8H16NO9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16446 xref: KEGG:C04501 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04525 name: fecosterol namespace: compound synonym: "C28H46O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C28H46O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h18,20-22,24-25,29H,3,7-17H2,1-2,4-6H3/t20-,21+,22+,24-,25+,27+,28-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17038 xref: KEGG:C04525 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04553 name: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate namespace: compound synonym: "C7H6O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H6O6/c8-5(9)2-4-3(7(11)12)1-6(10)13-4/h1,4H,2H2,(H,8,9)(H,11,12)" RELATED InChI [UPa:] xref: CHEBI:16989 xref: KEGG:C04553 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04556 name: 4-amino-2-methyl-5-phosphomethylpyrimidine namespace: compound synonym: "4-amino-5-phosphomethyl-2-methylpyrimidine" EXACT [KEGG:KEGG] synonym: "C6H10N3O4P" RELATED FORMULA [KEGG:COMPOUND] synonym: "HMP-P" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H10N3O4P/c1-4-8-2-5(6(7)9-4)3-13-14(10,11)12/h2H,3H2,1H3,(H2,7,8,9)(H2,10,11,12)" RELATED InChI [UPa:] xref: CHEBI:18032 xref: KEGG:C04556 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04570 name: reduced electron-transferring flavoprotein namespace: compound xref: KEGG:C04570 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04578 name: 3-hydroxy-16-methoxy-2,3-dihydrotabersonine namespace: compound synonym: "16-methoxy-2,3-dihydro-3-hydroxytabersonine" EXACT [KEGG:KEGG] synonym: "C22H28N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C22H28N2O4/c1-4-20-8-5-10-24-11-9-21(18(20)24)15-7-6-14(27-2)12-16(15)23-17(21)22(26,13-20)19(25)28-3/h5-8,12,17-18,23,26H,4,9-11,13H2,1-3H3/t17-,18+,20+,21+,22-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18430 xref: KEGG:C04578 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04582 name: S-methyl-5-thio-D-ribulose 1-phosphate namespace: compound synonym: "C6H13O7PS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O7PS/c1-15-3-5(8)6(9)4(7)2-13-14(10,11)12/h5-6,8-9H,2-3H2,1H3,(H2,10,11,12)/t5-,6+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28096 xref: KEGG:C04582 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04592 name: (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol namespace: compound synonym: "C7H10O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H10O2/c1-5-3-2-4-6(8)7(5)9/h2-4,6-9H,1H3/t6-,7+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15565 xref: KEGG:C04592 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04628 name: coenzyme B namespace: compound synonym: "C11H22NO6PS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H22NO7PS/c1-8(19-20(16,17)18)10(11(14)15)12-9(13)6-4-2-3-5-7-21/h8,10,21H,2-7H2,1H3,(H,12,13)(H,14,15)(H2,16,17,18)/t8-,10+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28890 xref: KEGG:C04628 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04640 name: 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine namespace: compound synonym: "2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine" EXACT [KEGG:KEGG] synonym: "C8H16N3O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H16N3O8P/c9-5(1-10-3-12)11-8-7(14)6(13)4(19-8)2-18-20(15,16)17/h3-4,6-8,13-14H,1-2H2,(H2,9,11)(H,10,12)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18413 xref: KEGG:C04640 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04642 name: 5-carboxymethyl-2-hydroxymuconate semialdehyde namespace: compound synonym: "C8H8O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H8O6/c9-4-5(3-7(11)12)1-2-6(10)8(13)14/h1-2,4,10H,3H2,(H,11,12)(H,13,14)/b5-1-,6-2+" RELATED InChI [UPa:] xref: CHEBI:17142 xref: KEGG:C04642 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04652 name: UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine namespace: compound synonym: "C43H77N3O20P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C43H77N3O20P2/c1-3-5-7-9-11-13-15-17-19-21-29(48)25-34(51)44-36-40(64-35(52)26-30(49)22-20-18-16-14-12-10-8-6-4-2)38(54)31(27-47)63-42(36)65-68(59,60)66-67(57,58)61-28-32-37(53)39(55)41(62-32)46-24-23-33(50)45-43(46)56/h23-24,29-32,36-42,47-49,53-55H,3-22,25-28H2,1-2H3,(H,44,51)(H,57,58)(H,59,60)(H,45,50,56)/t29-,30-,31-,32-,36-,37-,38-,39-,40-,41-,42-/m1/s1" RELATED InChI [UPa:] synonym: "UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine" EXACT [KEGG:KEGG] xref: CHEBI:17787 xref: KEGG:C04652 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04666 name: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate namespace: compound synonym: "C6H11N2O6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "ImPG" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H11N2O6P/c9-5(2-14-15(11,12)13)6(10)4-1-7-3-8-4/h1,3,5-6,9-10H,2H2,(H,7,8)(H2,11,12,13)/t5-,6+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17805 xref: KEGG:C04666 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04677 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide namespace: compound synonym: "C9H15N4O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H15N4O8P/c10-7-4(8(11)16)12-2-13(7)9-6(15)5(14)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,14-15H,1,10H2,(H2,11,16)(H2,17,18,19)/t3-,5-,6-,9-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18406 xref: KEGG:C04677 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04688 name: (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] namespace: compound xref: KEGG:C04688 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04691 name: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate namespace: compound synonym: "C7H13O10P" RELATED FORMULA [KEGG:COMPOUND] synonym: "DAHP" EXACT [KEGG:KEGG] synonym: "InChI=1S/C7H13O10P/c8-3(1-4(9)7(12)13)6(11)5(10)2-17-18(14,15)16/h3,5-6,8,10-11H,1-2H2,(H,12,13)(H2,14,15,16)/t3-,5-,6+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18150 xref: KEGG:C04691 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04732 name: 5-amino-6-(D-ribitylamino)uracil namespace: compound synonym: "6,7-dimethyl-8-(1-D-ribityl)lumazine" EXACT [KEGG:KEGG] synonym: "C9H16N4O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H16N4O6/c10-5-7(12-9(19)13-8(5)18)11-1-3(15)6(17)4(16)2-14/h3-4,6,14-17H,1-2,10H2,(H3,11,12,13,18,19)/t3-,4+,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15934 xref: KEGG:C04732 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04734 name: 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide namespace: compound synonym: "C10H15N4O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H15N4O9P/c11-8(18)5-9(13-3-15)14(2-12-5)10-7(17)6(16)4(23-10)1-22-24(19,20)21/h2-4,6-7,10,16-17H,1H2,(H2,11,18)(H,13,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18381 xref: KEGG:C04734 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04738 name: UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine namespace: compound synonym: "C31H53N3O19P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C31H53N3O19P2/c1-3-4-5-6-7-8-9-10-11-12-19(37)15-23(39)51-28-24(32-18(2)36)30(50-20(16-35)26(28)41)52-55(46,47)53-54(44,45)48-17-21-25(40)27(42)29(49-21)34-14-13-22(38)33-31(34)43/h13-14,19-21,24-30,35,37,40-42H,3-12,15-17H2,1-2H3,(H,32,36)(H,44,45)(H,46,47)(H,33,38,43)/t19-,20-,21-,24-,25-,26-,27-,28-,29-,30-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:61537 xref: KEGG:C04738 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04751 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate namespace: compound synonym: "C9H14N3O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H14N3O9P/c10-7-4(9(15)16)11-2-12(7)8-6(14)5(13)3(21-8)1-20-22(17,18)19/h2-3,5-6,8,13-14H,1,10H2,(H,15,16)(H2,17,18,19)/t3-,5-,6-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28413 xref: KEGG:C04751 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04752 name: 4-amino-2-methyl-5-diphosphomethylpyrimidine namespace: compound synonym: "C6H11N3O7P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "HMP-PP" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H11N3O7P2/c1-4-8-2-5(6(7)9-4)3-15-18(13,14)16-17(10,11)12/h2H,3H2,1H3,(H,13,14)(H2,7,8,9)(H2,10,11,12)" RELATED InChI [UPa:] xref: CHEBI:16629 xref: KEGG:C04752 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04778 name: alpha-ribazole 5'-phosphate namespace: compound synonym: "C14H19N2O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H19N2O7P/c1-7-3-9-10(4-8(7)2)16(6-15-9)14-13(18)12(17)11(23-14)5-22-24(19,20)21/h3-4,6,11-14,17-18H,5H2,1-2H3,(H2,19,20,21)/t11-,12-,13-,14+/m1/s1" RELATED InChI [UPa:] synonym: "N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole" EXACT [KEGG:KEGG] xref: CHEBI:16837 xref: KEGG:C04778 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04783 name: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid namespace: compound synonym: "C8H8O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H8O6/c9-5-1-3(7(11)12)4(8(13)14)2-6(5)10/h1-2,5-6,9-10H,(H,11,12)(H,13,14)/t5-,6+" RELATED InChI [UPa:] xref: CHEBI:17692 xref: KEGG:C04783 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04807 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate namespace: compound synonym: "C7H11N5O8P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H11N5O8P2/c8-7-11-5-4(6(13)12-7)10-3(1-9-5)2-19-22(17,18)20-21(14,15)16/h1-2H2,(H,17,18)(H2,14,15,16)(H4,8,9,11,12,13)" RELATED InChI [UPa:] xref: CHEBI:15998 xref: CHEBI:73083 xref: KEGG:C04807 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04823 name: (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid namespace: compound synonym: "(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate" EXACT [KEGG:KEGG] synonym: "C13H19N4O12P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C13H19N4O12P/c14-10-7(11(22)16-4(13(23)24)1-6(18)19)15-3-17(10)12-9(21)8(20)5(29-12)2-28-30(25,26)27/h3-5,8-9,12,20-21H,1-2,14H2,(H,16,22)(H,18,19)(H,23,24)(H2,25,26,27)/t4-,5+,8+,9+,12+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18319 xref: KEGG:C04823 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04824 name: lipid X namespace: compound synonym: "2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate" EXACT [KEGG:KEGG] synonym: "C34H66NO12P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C34H66NO12P/c1-3-5-7-9-11-13-15-17-19-21-26(37)23-29(39)35-31-33(32(41)28(25-36)45-34(31)47-48(42,43)44)46-30(40)24-27(38)22-20-18-16-14-12-10-8-6-4-2/h26-28,31-34,36-38,41H,3-25H2,1-2H3,(H,35,39)(H2,42,43,44)/t26-,27-,28-,31-,32-,33-,34-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16942 xref: KEGG:C04824 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04832 name: coenzyme M-coenzyme B heterodisulfide namespace: compound synonym: "C13H26NO10PS3" RELATED FORMULA [KEGG:COMPOUND] synonym: "CoB-CoM heterodisulfide" EXACT [KEGG:KEGG] synonym: "InChI=1S/C13H26NO10PS3/c1-10(24-25(18,19)20)12(13(16)17)14-11(15)6-4-2-3-5-7-26-27-8-9-28(21,22)23/h10,12H,2-9H2,1H3,(H,14,15)(H,16,17)(H2,18,19,20)(H,21,22,23)/t10-,12+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18209 xref: KEGG:C04832 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04874 name: 7,8-dihydroneopterin namespace: compound synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine" EXACT [KEGG:KEGG] synonym: "C9H13N5O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17001 xref: KEGG:C04874 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04895 name: 7,8-dihydroneopterin triphosphate namespace: compound synonym: "2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate" EXACT [KEGG:KEGG] synonym: "C9H16N5O13P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/t4-,6+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18372 xref: KEGG:C04895 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04896 name: 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide namespace: compound synonym: "C15H25N5O15P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H25N5O15P2/c16-12(25)7-13(17-3-18-14-10(23)8(21)5(34-14)1-32-36(26,27)28)20(4-19-7)15-11(24)9(22)6(35-15)2-33-37(29,30)31/h3-6,8-11,14-15,21-24H,1-2H2,(H2,16,25)(H,17,18)(H2,26,27,28)(H2,29,30,31)/t5-,6-,8-,9-,10-,11-,14-,15-/m1/s1" RELATED InChI [UPa:] synonym: "phosphoribosyl-formimino-AICAR-phosphate" EXACT [KEGG:KEGG] xref: CHEBI:18302 xref: KEGG:C04896 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04916 name: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide namespace: compound synonym: "C15H25N5O15P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H25N5O15P2/c16-13(26)9-14(18-4-17-1-6(21)10(23)7(22)2-33-36(27,28)29)20(5-19-9)15-12(25)11(24)8(35-15)3-34-37(30,31)32/h4-5,7-8,10-12,15,22-25H,1-3H2,(H2,16,26)(H,17,18)(H2,27,28,29)(H2,30,31,32)/t7-,8-,10+,11-,12-,15-/m1/s1" RELATED InChI [UPa:] synonym: "phosphoribulosyl-formimino-AICAR-phosphate" EXACT [KEGG:KEGG] xref: CHEBI:27735 xref: KEGG:C04916 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04919 name: lipid IV(A) namespace: compound synonym: "C68H130N2O23P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C68H130N2O23P2/c1-5-9-13-17-21-25-29-33-37-41-51(72)45-57(76)69-61-65(90-59(78)47-53(74)43-39-35-31-27-23-19-15-11-7-3)63(80)56(89-68(61)93-95(84,85)86)50-87-67-62(70-58(77)46-52(73)42-38-34-30-26-22-18-14-10-6-2)66(64(55(49-71)88-67)92-94(81,82)83)91-60(79)48-54(75)44-40-36-32-28-24-20-16-12-8-4/h51-56,61-68,71-75,80H,5-50H2,1-4H3,(H,69,76)(H,70,77)(H2,81,82,83)(H2,84,85,86)/t51-,52-,53-,54-,55-,56-,61-,62-,63-,64-,65-,66-,67-,68-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:29056 xref: KEGG:C04919 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC04932 name: 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate namespace: compound synonym: "2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate" EXACT [KEGG:KEGG] synonym: "C68H129N2O20P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C68H129N2O20P/c1-5-9-13-17-21-25-29-33-37-41-51(72)45-57(76)69-61-65(88-59(78)47-53(74)43-39-35-31-27-23-19-15-11-7-3)63(80)55(49-71)86-67(61)85-50-56-64(81)66(89-60(79)48-54(75)44-40-36-32-28-24-20-16-12-8-4)62(68(87-56)90-91(82,83)84)70-58(77)46-52(73)42-38-34-30-26-22-18-14-10-6-2/h51-56,61-68,71-75,80-81H,5-50H2,1-4H3,(H,69,76)(H,70,77)(H2,82,83,84)/t51-,52-,53-,54-,55-,56-,61-,62-,63-,64-,65-,66-,67-,68-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18380 xref: KEGG:C04932 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05042 name: phosphinothricin namespace: compound synonym: "C5H12NO4P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H12NO4P/c1-11(9,10)3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:52136 xref: KEGG:C05042 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05080 name: novobiocin namespace: compound synonym: "C31H36N2O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37)/t23-,25+,26-,29-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28368 xref: KEGG:C05080 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05103 name: 4-alpha-methylzymosterol namespace: compound synonym: "4alpha-methylzymosterol" EXACT [KEGG:KEGG] synonym: "C28H46O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C28H46O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24,26,29H,7,9-17H2,1-6H3/t19-,20?,22?,23+,24?,26+,27-,28+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:1949 xref: KEGG:C05103 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05108 name: 14-demethyllanosterol namespace: compound synonym: "C29H48O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23?,25+,26+,28-,29-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18364 xref: KEGG:C05108 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05125 name: 2-hydroxyethyl-ThPP namespace: compound synonym: "C14H23N4O8P2S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H22N4O8P2S/c1-8-12(4-5-25-28(23,24)26-27(20,21)22)29-14(9(2)19)18(8)7-11-6-16-10(3)17-13(11)15/h6,9,19H,4-5,7H2,1-3H3,(H4-,15,16,17,20,21,22,23,24)/p+1" RELATED InChI [UPa:] xref: CHEBI:978 xref: KEGG:C05125 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05143 name: dhurrin namespace: compound synonym: "C14H17NO7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H17NO7/c15-5-9(7-1-3-8(17)4-2-7)21-14-13(20)12(19)11(18)10(6-16)22-14/h1-4,9-14,16-20H,6H2/t9-,10-,11-,12+,13-,14-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27826 xref: KEGG:C05143 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05172 name: selenophosphate namespace: compound synonym: "H3O3PSe" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/H3O3PSe/c1-4(2,3)5/h(H3,1,2,3,5)" RELATED InChI [UPa:] xref: CHEBI:26641 xref: CHEBI:29269 xref: CHEBI:64331 xref: KEGG:C05172 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05176 name: (S)-N-methylcoclaurine namespace: compound synonym: "C18H21NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C18H21NO3/c1-19-8-7-13-10-18(22-2)17(21)11-15(13)16(19)9-12-3-5-14(20)6-4-12/h3-6,10-11,16,20-21H,7-9H2,1-2H3/t16-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17041 xref: KEGG:C05176 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05177 name: berbamunine namespace: compound synonym: "C36H40N2O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C36H40N2O6/c1-37-13-11-24-18-34(42-3)32(40)20-27(24)29(37)15-22-5-8-26(9-6-22)44-36-17-23(7-10-31(36)39)16-30-28-21-33(41)35(43-4)19-25(28)12-14-38(30)2/h5-10,17-21,29-30,39-41H,11-16H2,1-4H3/t29-,30+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16777 xref: KEGG:C05177 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05198 name: 5'-deoxyadenosine namespace: compound synonym: "C10H13N5O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H13N5O3/c1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15/h2-4,6-7,10,16-17H,1H3,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17319 xref: KEGG:C05198 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05202 name: (S)-3'-hydroxy-N-methylcoclaurine namespace: compound synonym: "3'-hydroxy-N-methyl-(S)-coclaurine" EXACT [KEGG:KEGG] synonym: "C18H21NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C18H21NO4/c1-19-6-5-12-9-18(23-2)17(22)10-13(12)14(19)7-11-3-4-15(20)16(21)8-11/h3-4,8-10,14,20-22H,5-7H2,1-2H3/t14-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17079 xref: KEGG:C05202 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05223 name: dodecanoyl-[acyl-carrier protein] namespace: compound xref: KEGG:C05223 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05243 name: (R)-N-methylcoclaurine namespace: compound synonym: "C18H21NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C18H21NO3/c1-19-8-7-13-10-18(22-2)17(21)11-15(13)16(19)9-12-3-5-14(20)6-4-12/h3-6,10-11,16,20-21H,7-9H2,1-2H3/t16-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16387 xref: KEGG:C05243 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05315 name: palmatine namespace: compound synonym: "C21H22NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C21H22NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,9-12H,7-8H2,1-4H3/q+1" RELATED InChI [UPa:] xref: CHEBI:16096 xref: KEGG:C05315 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05325 name: purine nucleotide namespace: compound synonym: "C10H13N4O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H13N4O7P/c15-7-6(2-20-22(17,18)19)21-10(8(7)16)14-4-13-5-1-11-3-12-9(5)14/h1,3-4,6-8,10,15-16H,2H2,(H2,17,18,19)/t6-,7-,8-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:45262 xref: KEGG:C05325 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05332 name: 2-phenylethylamine namespace: compound synonym: "C8H11N" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2" RELATED InChI [UPa:] synonym: "phenethylamine" EXACT [KEGG:KEGG] xref: CHEBI:18397 xref: KEGG:C05332 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05345 name: beta-D-fructose 6-phosphate namespace: compound synonym: "C6H13O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/t3-,4-,5+,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16084 xref: KEGG:C05345 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05359 name: e- namespace: compound xref: CHEBI:10545 xref: KEGG:C05359 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05381 name: 3-carboxy-1-hydroxypropylthiamine diphosphate namespace: compound synonym: "C16H25N4O10P2S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C16H24N4O10P2S/c1-9-13(5-6-29-32(27,28)30-31(24,25)26)33-16(12(21)3-4-14(22)23)20(9)8-11-7-18-10(2)19-15(11)17/h7,12,21H,3-6,8H2,1-2H3,(H5-,17,18,19,22,23,24,25,26,27,28)/p+1" RELATED InChI [UPa:] xref: CHEBI:1463 xref: KEGG:C05381 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05382 name: sedoheptulose 7-phosphate namespace: compound synonym: "C7H15O10P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H15O10P/c8-1-3(9)5(11)7(13)6(12)4(10)2-17-18(14,15)16/h4-8,10-13H,1-2H2,(H2,14,15,16)/t4-,5-,6-,7+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15721 xref: KEGG:C05382 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05396 name: lactose 6-phosphate namespace: compound synonym: "C12H23O14P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H23O14P/c13-1-3-10(7(16)8(17)11(19)24-3)26-12-9(18)6(15)5(14)4(25-12)2-23-27(20,21)22/h3-19H,1-2H2,(H2,20,21,22)/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28339 xref: KEGG:C05396 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05413 name: all-trans-phytoene namespace: compound synonym: "C40H64" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H64/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,19-22,27-30H,13-18,23-26,31-32H2,1-10H3/b12-11+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+" RELATED InChI [UPa:] synonym: "phytoene" EXACT [KEGG:KEGG] xref: CHEBI:26119 xref: CHEBI:8191 xref: KEGG:C05413 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05421 name: 15-cis-phytoene namespace: compound synonym: "C40H64" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H64/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,19-22,27-30H,13-18,23-26,31-32H2,1-10H3/b12-11-,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+" RELATED InChI [UPa:] xref: CHEBI:27787 xref: KEGG:C05421 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05422 name: L-dehydroascorbate namespace: compound synonym: "C6H6O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H6O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-8H,1H2/t2-,5+/m0/s1" RELATED InChI [UPa:] synonym: "L-dehydroascorbic acid" EXACT [KEGG:KEGG] xref: CHEBI:27956 xref: KEGG:C05422 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05431 name: neurosporene namespace: compound synonym: "C40H58" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H58/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-17,19-22,25-31H,13-14,18,23-24,32H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+" RELATED InChI [UPa:] xref: CHEBI:16833 xref: KEGG:C05431 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05437 name: zymosterol namespace: compound synonym: "C27H44O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18252 xref: KEGG:C05437 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05440 name: ergosta-5,7,22,24(28)-tetraen-3beta-ol namespace: compound synonym: "C28H42O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C28H42O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,18,20,22,24-26,29H,3,11-17H2,1-2,4-6H3/b8-7+/t20-,22+,24?,25?,26?,27+,28-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18249 xref: KEGG:C05440 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05519 name: L-allo-threonine namespace: compound synonym: "C4H9NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:28718 xref: KEGG:C05519 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05528 name: 3-sulfopyruvate namespace: compound synonym: "C3H4O6S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)" RELATED InChI [UPa:] xref: CHEBI:16894 xref: KEGG:C05528 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05533 name: 2-oxaloglutaric acid namespace: compound synonym: "C7H8O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H8O7/c8-4(9)2-1-3(6(11)12)5(10)7(13)14/h3H,1-2H2,(H,8,9)(H,11,12)(H,13,14)" RELATED InChI [UPa:] xref: CHEBI:7814 xref: KEGG:C05533 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05535 name: alpha-aminoadipoyl-S-acyl enzyme namespace: compound xref: CHEBI:10211 xref: CHEBI:20537 xref: KEGG:C05535 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05539 name: (S)-2-acetamido-6-oxopimelate namespace: compound synonym: "C9H13NO6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H13NO6/c1-5(11)10-6(8(13)14)3-2-4-7(12)9(15)16/h6H,2-4H2,1H3,(H,10,11)(H,13,14)(H,15,16)/t6-/m0/s1" RELATED InChI [UPa:] synonym: "N-acetyl 2-amino-6-oxopimelate" EXACT [KEGG:KEGG] xref: CHEBI:17355 xref: KEGG:C05539 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05548 name: 6-acetamido-2-oxohexanoate namespace: compound synonym: "C8H13NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H13NO4/c1-6(10)9-5-3-2-4-7(11)8(12)13/h2-5H2,1H3,(H,9,10)(H,12,13)" RELATED InChI [UPa:] xref: CHEBI:28376 xref: KEGG:C05548 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05551 name: penicillin G namespace: compound synonym: "C16H18N2O4S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18208 xref: KEGG:C05551 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05554 name: aerobactin namespace: compound synonym: "C22H36N4O13" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C22H36N4O13/c1-13(27)25(38)9-5-3-7-15(19(31)32)23-17(29)11-22(37,21(35)36)12-18(30)24-16(20(33)34)8-4-6-10-26(39)14(2)28/h15-16,37-39H,3-12H2,1-2H3,(H,23,29)(H,24,30)(H,31,32)(H,33,34)(H,35,36)/t15-,16-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18157 xref: KEGG:C05554 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05556 name: N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine namespace: compound synonym: "C14H25N3O6S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H25N3O6S/c1-7(2)11(14(22)23)17-12(19)9(6-24)16-10(18)5-3-4-8(15)13(20)21/h7-9,11,24H,3-6,15H2,1-2H3,(H,16,18)(H,17,19)(H,20,21)(H,22,23)/t8-,9?,11+/m0/s1" RELATED InChI [UPa:] synonym: "N-(L-5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine" EXACT [KEGG:KEGG] xref: CHEBI:28496 xref: KEGG:C05556 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05557 name: isopenicillin N namespace: compound synonym: "C14H21N3O6S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H21N3O6S/c1-14(2)9(13(22)23)17-10(19)8(11(17)24-14)16-7(18)5-3-4-6(15)12(20)21/h6,8-9,11H,3-5,15H2,1-2H3,(H,16,18)(H,20,21)(H,22,23)/t6-,8+,9-,11+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18165 xref: KEGG:C05557 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05560 name: alpha-aminoadipoyl-C6-AMP namespace: compound synonym: "C16H23N6O10P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C16H23N6O10P/c17-7(16(26)27)2-1-3-9(23)32-33(28,29)30-4-8-11(24)12(25)15(31-8)22-6-21-10-13(18)19-5-20-14(10)22/h5-8,11-12,15,24-25H,1-4,17H2,(H,26,27)(H,28,29)(H2,18,19,20)/t7-,8+,11+,12+,15+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:20536 xref: CHEBI:6163 xref: KEGG:C05560 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05570 name: ergothioneine namespace: compound synonym: "C9H16N3O2S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/p+1/t7-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:4828 xref: CHEBI:82707 xref: KEGG:C05570 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05600 name: 2-hydroxy-hept-2,4-diene-1,7-dioic acid namespace: compound synonym: "2-hydroxy-hept-2,4-diene-1,7-dioate" EXACT [KEGG:KEGG] synonym: "C7H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H8O5/c8-5(7(11)12)3-1-2-4-6(9)10/h1-3,8H,4H2,(H,9,10)(H,11,12)/b2-1+,5-3-" RELATED InChI [UPa:] xref: CHEBI:1162 xref: KEGG:C05600 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05618 name: 3-chlorocatechol namespace: compound synonym: "C6H5ClO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H5ClO2/c7-4-2-1-3-5(8)6(4)9/h1-3,8-9H" RELATED InChI [UPa:] xref: CHEBI:27715 xref: KEGG:C05618 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05629 name: 3-phenylpropanoate namespace: compound synonym: "3-phenylpropionic acid" EXACT [KEGG:KEGG] synonym: "C9H10O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H10O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,11)" RELATED InChI [UPa:] xref: CHEBI:28631 xref: KEGG:C05629 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05662 name: homoisocitrate namespace: compound synonym: "C7H10O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "homoisocitric acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C7H10O7/c8-4(9)2-1-3(6(11)12)5(10)7(13)14/h3,5,10H,1-2H2,(H,8,9)(H,11,12)(H,13,14)/t3-,5+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15404 xref: CHEBI:30903 xref: CHEBI:30904 xref: KEGG:C05662 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05752 name: octanoyl-[acyl-carrier-protein] namespace: compound xref: CHEBI:7725 xref: KEGG:C05752 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05761 name: tetradecanoyl-[acp] namespace: compound xref: CHEBI:50651 xref: KEGG:C05761 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05772 name: precorrin-3A namespace: compound synonym: "C43H50N4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C43H50N4O16/c1-19-40-23(13-37(58)59)21(5-9-33(50)51)27(46-40)14-26-20(4-8-32(48)49)22(12-36(56)57)28(44-26)15-29-24(6-10-34(52)53)42(2,17-38(60)61)31(45-29)16-30-25(7-11-35(54)55)43(3,18-39(62)63)41(19)47-30/h15-16,24-25,44,46-47H,4-14,17-18H2,1-3H3,(H,48,49)(H,50,51)(H,52,53)(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H,62,63)/b29-15-,30-16-,41-19-/t24-,25-,42+,43+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28307 xref: KEGG:C05772 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05773 name: cob(III)yrinic acid namespace: compound synonym: "C45H59CoN4O14" RELATED FORMULA [KEGG:COMPOUND] synonym: "cobyrinate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C45H60N4O14.Co/c1-21-36-24(10-13-30(52)53)41(3,4)28(47-36)18-27-23(9-12-29(50)51)43(6,19-34(60)61)39(46-27)22(2)37-25(11-14-31(54)55)44(7,20-35(62)63)45(8,49-37)40-26(17-33(58)59)42(5,38(21)48-40)16-15-32(56)57;/h18,23-26,40H,9-17,19-20H2,1-8H3,(H8,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63);/q;+2/p-1/t23-,24-,25-,26+,40-,42-,43+,44+,45+;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:33907 xref: KEGG:C05773 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05775 name: alpha-ribazole namespace: compound synonym: "C14H18N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H18N2O4/c1-7-3-9-10(4-8(7)2)16(6-15-9)14-13(19)12(18)11(5-17)20-14/h3-4,6,11-14,17-19H,5H2,1-2H3/t11-,12-,13-,14+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:10329 xref: KEGG:C05775 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05778 name: sirohydrochlorin namespace: compound synonym: "C42H46N4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C42H46N4O16/c1-41(17-39(59)60)23(5-9-35(51)52)29-14-27-21(11-37(55)56)19(3-7-33(47)48)25(43-27)13-26-20(4-8-34(49)50)22(12-38(57)58)28(44-26)15-31-42(2,18-40(61)62)24(6-10-36(53)54)30(46-31)16-32(41)45-29/h13-16,23-24,44-45H,3-12,17-18H2,1-2H3,(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H,61,62)/b25-13-,29-14-,31-15-,32-16-/t23-,24-,41+,42+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18023 xref: KEGG:C05778 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05817 name: (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid namespace: compound synonym: "(1S,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate" EXACT [KEGG:KEGG] synonym: "C11H12O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H12O6/c12-7(4-5-9(14)15)6-2-1-3-8(13)10(6)11(16)17/h1-3,8,10,13H,4-5H2,(H,14,15)(H,16,17)/t8-,10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:39564 xref: KEGG:C05817 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05818 name: 2-demethylmenaquinone namespace: compound synonym: "C20H22O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C20H22O2/c1-14(2)7-6-8-15(3)11-12-16-13-19(21)17-9-4-5-10-18(17)20(16)22/h4-5,7,9-11,13H,6,8,12H2,1-3H3/b15-11+" RELATED InChI [UPa:] xref: CHEBI:28192 xref: KEGG:C05818 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05819 name: menaquinol namespace: compound synonym: "C21H26O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C21H26O2/c1-14(2)8-7-9-15(3)12-13-17-16(4)20(22)18-10-5-6-11-19(18)21(17)23/h5-6,8,10-12,22-23H,7,9,13H2,1-4H3/b15-12+" RELATED InChI [UPa:] xref: CHEBI:18151 xref: KEGG:C05819 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05821 name: enterochelin namespace: compound synonym: "C30H27N3O15" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C30H27N3O15/c34-19-7-1-4-13(22(19)37)25(40)31-16-10-46-29(44)18(33-27(42)15-6-3-9-21(36)24(15)39)12-48-30(45)17(11-47-28(16)43)32-26(41)14-5-2-8-20(35)23(14)38/h1-9,16-18,34-39H,10-12H2,(H,31,40)(H,32,41)(H,33,42)/t16-,17-,18-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:28855 xref: KEGG:C05821 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05840 name: iminoaspartate namespace: compound synonym: "C4H5NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H5NO4/c5-2(4(8)9)1-3(6)7/h5H,1H2,(H,6,7)(H,8,9)" RELATED InChI [UPa:] xref: CHEBI:50616 xref: KEGG:C05840 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05847 name: all-trans-polyprenyl diphosphate namespace: compound synonym: "C10H20O7P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/b10-7+" RELATED InChI [UPa:] xref: CHEBI:37531 xref: CHEBI:55337 xref: KEGG:C05847 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05922 name: formamidopyrimidine nucleoside triphosphate namespace: compound synonym: "C10H18N5O15P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H18N5O15P3/c11-10-14-7(4(12-2-16)8(19)15-10)13-9-6(18)5(17)3(28-9)1-27-32(23,24)30-33(25,26)29-31(20,21)22/h2-3,5-6,9,17-18H,1H2,(H,12,16)(H,23,24)(H,25,26)(H2,20,21,22)(H4,11,13,14,15,19)/t3-,5-,6-,9-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27985 xref: KEGG:C05922 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05923 name: 2,5-diaminopyrimidine nucleoside triphosphate namespace: compound synonym: "C9H18N5O14P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H18N5O14P3/c10-3-6(13-9(11)14-7(3)17)12-8-5(16)4(15)2(26-8)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2,4-5,8,15-16H,1,10H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,11,12,13,14,17)/t2-,4-,5-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:929 xref: KEGG:C05923 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05925 name: 7,8-dihydroneopterin 3'-phosphate namespace: compound synonym: "2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine phosphate" EXACT [KEGG:KEGG] synonym: "C9H14N5O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H14N5O7P/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-21-22(18,19)20/h4,6,15-16H,1-2H2,(H2,18,19,20)(H4,10,11,13,14,17)/t4-,6+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:48954 xref: KEGG:C05925 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05931 name: N(2)-succinyl-L-glutamic acid namespace: compound synonym: "C9H13NO7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H13NO7/c11-6(2-4-8(14)15)10-5(9(16)17)1-3-7(12)13/h5H,1-4H2,(H,10,11)(H,12,13)(H,14,15)(H,16,17)/t5-/m0/s1" RELATED InChI [UPa:] synonym: "N-succinyl-L-glutamate" EXACT [KEGG:KEGG] xref: CHEBI:48957 xref: KEGG:C05931 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC05932 name: N-succinyl-L-glutamate 5-semialdehyde namespace: compound synonym: "C9H13NO6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H13NO6/c11-5-1-2-6(9(15)16)10-7(12)3-4-8(13)14/h5-6H,1-4H2,(H,10,12)(H,13,14)(H,15,16)/t6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:27657 xref: KEGG:C05932 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06006 name: (S)-2-acetyl-2-hydroxybutanoic acid namespace: compound synonym: "(S)-2-aceto-2-hydroxybutanoate" EXACT [KEGG:KEGG] synonym: "C6H10O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O4/c1-3-6(10,4(2)7)5(8)9/h10H,3H2,1-2H3,(H,8,9)/t6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:27681 xref: CHEBI:49256 xref: KEGG:C06006 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06007 name: (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid namespace: compound synonym: "(R)-2,3-dihydroxy-3-methylpentanoate" EXACT [KEGG:KEGG] synonym: "C6H12O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12O4/c1-3-6(2,10)4(7)5(8)9/h4,7,10H,3H2,1-2H3,(H,8,9)/t4-,6+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:27512 xref: CHEBI:49258 xref: KEGG:C06007 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06008 name: (R)-2-oxo-3-methylpentanoate namespace: compound synonym: "C6H10O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/t4-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28379 xref: KEGG:C06008 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06010 name: (S)-2-acetolactate namespace: compound synonym: "(S)-2-acetolactic acid" EXACT [KEGG:KEGG] synonym: "C5H8O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H8O4/c1-3(6)5(2,9)4(7)8/h9H,1-2H3,(H,7,8)/t5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18409 xref: KEGG:C06010 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06019 name: D-arabino-3-hexulose 6-phosphate namespace: compound synonym: "C6H13O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h3-4,6-9,11H,1-2H2,(H2,12,13,14)/t3-,4-,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27973 xref: KEGG:C06019 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06022 name: UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine namespace: compound synonym: "C29H51N3O18P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C29H51N3O18P2/c1-2-3-4-5-6-7-8-9-10-11-17(34)14-21(36)48-26-22(30)28(47-18(15-33)24(26)38)49-52(43,44)50-51(41,42)45-16-19-23(37)25(39)27(46-19)32-13-12-20(35)31-29(32)40/h12-13,17-19,22-28,33-34,37-39H,2-11,14-16,30H2,1H3,(H,41,42)(H,43,44)(H,31,35,40)/t17-,18-,19-,22-,23-,24-,25-,26-,27-,28-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:71619 xref: KEGG:C06022 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06024 name: 3-deoxy-D-manno-octulosonyl-lipid IV((A)) namespace: compound synonym: "3-deoxy-D-manno-octulosonyl-lipid IV(A)" EXACT [KEGG:KEGG] synonym: "C76H142N2O30P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C76H142N2O30P2/c1-5-9-13-17-21-25-29-33-37-41-53(80)45-61(86)77-65-71(104-63(88)47-55(82)43-39-35-31-27-23-19-15-11-7-3)68(91)59(102-74(65)108-110(97,98)99)51-100-73-66(78-62(87)46-54(81)42-38-34-30-26-22-18-14-10-6-2)72(105-64(89)48-56(83)44-40-36-32-28-24-20-16-12-8-4)70(107-109(94,95)96)60(103-73)52-101-76(75(92)93)49-57(84)67(90)69(106-76)58(85)50-79/h53-60,65-74,79-85,90-91H,5-52H2,1-4H3,(H,77,86)(H,78,87)(H,92,93)(H2,94,95,96)(H2,97,98,99)/t53-,54-,55-,56-,57-,58-,59-,60-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,76-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27439 xref: KEGG:C06024 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06025 name: di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) namespace: compound synonym: "C84H154N2O37P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C84H154N2O37P2/c1-5-9-13-17-21-25-29-33-37-41-55(89)45-65(96)85-69-77(117-67(98)47-57(91)43-39-35-31-27-23-19-15-11-7-3)73(102)63(115-80(69)123-125(110,111)112)53-113-79-70(86-66(97)46-56(90)42-38-34-30-26-22-18-14-10-6-2)78(118-68(99)48-58(92)44-40-36-32-28-24-20-16-12-8-4)76(122-124(107,108)109)64(116-79)54-114-83(81(103)104)50-62(72(101)75(120-83)61(95)52-88)119-84(82(105)106)49-59(93)71(100)74(121-84)60(94)51-87/h55-64,69-80,87-95,100-102H,5-54H2,1-4H3,(H,85,96)(H,86,97)(H,103,104)(H,105,106)(H2,107,108,109)(H2,110,111,112)/t55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,83-,84-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28526 xref: KEGG:C06025 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06026 name: KDO(2)-lipid A namespace: compound synonym: "C110H202N2O39P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C110H202N2O39P2/c1-7-13-19-25-31-37-38-44-50-56-62-68-92(123)142-82(66-60-54-48-42-35-29-23-17-11-5)72-94(125)146-104-96(112-90(121)71-81(65-59-53-47-41-34-28-22-16-10-4)141-91(122)67-61-55-49-43-36-30-24-18-12-6)105(144-88(102(104)150-152(133,134)135)78-140-109(107(129)130)74-86(98(127)101(148-109)85(119)76-114)147-110(108(131)132)73-83(117)97(126)100(149-110)84(118)75-113)139-77-87-99(128)103(145-93(124)70-80(116)64-58-52-46-40-33-27-21-15-9-3)95(106(143-87)151-153(136,137)138)111-89(120)69-79(115)63-57-51-45-39-32-26-20-14-8-2/h79-88,95-106,113-119,126-128H,7-78H2,1-6H3,(H,111,120)(H,112,121)(H,129,130)(H,131,132)(H2,133,134,135)(H2,136,137,138)/t79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,109-,110-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27963 xref: KEGG:C06026 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06032 name: D-erythro-3-methylmalic acid namespace: compound synonym: "C5H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-erythro-3-methylmalate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C5H8O5/c1-2(4(7)8)3(6)5(9)10/h2-3,6H,1H3,(H,7,8)(H,9,10)/t2-,3+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:27394 xref: KEGG:C06032 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06054 name: (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid namespace: compound synonym: "(3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate" EXACT [KEGG:KEGG] synonym: "C4H7O8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H7O8P/c5-2(3(6)4(7)8)1-12-13(9,10)11/h2,5H,1H2,(H,7,8)(H2,9,10,11)/t2-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27951 xref: KEGG:C06054 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06055 name: 4-(phosphonooxy)-L-threonine namespace: compound synonym: "C4H10NO7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H10NO7P/c5-3(4(7)8)2(6)1-12-13(9,10)11/h2-3,6H,1,5H2,(H,7,8)(H2,9,10,11)/t2-,3+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18336 xref: KEGG:C06055 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06078 name: limonene namespace: compound synonym: "C10H16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3" RELATED InChI [UPa:] xref: CHEBI:15384 xref: KEGG:C06078 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06099 name: (4R)-limonene namespace: compound synonym: "C10H16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3/t10-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15382 xref: KEGG:C06099 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06118 name: 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid namespace: compound synonym: "4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate" EXACT [KEGG:KEGG] synonym: "C12H16O12" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H16O12/c13-2-1-3(9(17)18)22-12(4(2)14)24-7-5(15)6(16)11(21)23-8(7)10(19)20/h1-2,4-8,11-16,21H,(H,17,18)(H,19,20)/t2-,4+,5+,6+,7+,8-,11+,12+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:27450 xref: KEGG:C06118 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06148 name: 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine namespace: compound synonym: "C9H18N5O14P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H18N5O14P3/c10-5-7(13-9(11)14-8(5)18)12-1-3(15)6(17)4(16)2-26-30(22,23)28-31(24,25)27-29(19,20)21/h4,6,16-17H,1-2,10H2,(H,22,23)(H,24,25)(H2,19,20,21)(H4,11,12,13,14,18)" RELATED InChI [UPa:] xref: CHEBI:28003 xref: KEGG:C06148 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06156 name: alpha-D-glucosamine 1-phosphate namespace: compound synonym: "C6H14NO8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H14NO8P/c7-3-5(10)4(9)2(1-8)14-6(3)15-16(11,12)13/h2-6,8-10H,1,7H2,(H2,11,12,13)/t2-,3-,4-,5-,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27625 xref: KEGG:C06156 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06157 name: S(8)-glutaryldihydrolipoamide namespace: compound synonym: "S-glutaryldihydrolipoamide" EXACT [KEGG:KEGG] xref: CHEBI:28391 xref: KEGG:C06157 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06160 name: (S)-norcoclaurine namespace: compound synonym: "C16H17NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C16H17NO3/c18-12-3-1-10(2-4-12)7-14-13-9-16(20)15(19)8-11(13)5-6-17-14/h1-4,8-9,14,17-20H,5-7H2/t14-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17729 xref: KEGG:C06160 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06161 name: (S)-coclaurine namespace: compound synonym: "C17H19NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C17H19NO3/c1-21-17-9-12-6-7-18-15(14(12)10-16(17)20)8-11-2-4-13(19)5-3-11/h2-5,9-10,15,18-20H,6-8H2,1H3/t15-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15950 xref: KEGG:C06161 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06189 name: cyclic 2,3-diphosphoglycerate namespace: compound synonym: "C3H6O9P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H6O9P2/c4-3(5)2-1-10-13(6,7)12-14(8,9)11-2/h2H,1H2,(H,4,5)(H,6,7)(H,8,9)" RELATED InChI [UPa:] xref: CHEBI:28699 xref: KEGG:C06189 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06201 name: 2,4-dihydroxyhept-2-enedioic acid namespace: compound synonym: "2,4-dihydoxy-hept-2-ene-1,7-dioate" EXACT [KEGG:KEGG] synonym: "C7H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H10O6/c8-4(1-2-6(10)11)3-5(9)7(12)13/h3-4,8-9H,1-2H2,(H,10,11)(H,12,13)/b5-3-" RELATED InChI [UPa:] xref: CHEBI:58936 xref: CHEBI:915 xref: KEGG:C06201 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06231 name: L-ectoine namespace: compound synonym: "1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid" EXACT [KEGG:KEGG] synonym: "C6H10N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10N2O2/c1-4-7-3-2-5(8-4)6(9)10/h5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:27592 xref: KEGG:C06231 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06251 name: lauroyl-KDO(2)-lipid IV(A) namespace: compound synonym: "C96H176N2O38P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C96H176N2O38P2/c1-6-11-16-21-26-31-36-41-46-51-66(101)56-76(107)97-81-89(130-79(110)57-67(102)52-47-42-37-32-27-22-17-12-7-2)85(114)74(128-92(81)136-138(122,123)124)64-125-91-82(98-77(108)59-69(54-49-44-39-34-29-24-19-14-9-4)127-78(109)55-50-45-40-35-30-25-20-15-10-5)90(131-80(111)58-68(103)53-48-43-38-33-28-23-18-13-8-3)88(135-137(119,120)121)75(129-91)65-126-95(93(115)116)61-73(84(113)87(133-95)72(106)63-100)132-96(94(117)118)60-70(104)83(112)86(134-96)71(105)62-99/h66-75,81-92,99-106,112-114H,6-65H2,1-5H3,(H,97,107)(H,98,108)(H,115,116)(H,117,118)(H2,119,120,121)(H2,122,123,124)/t66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,95-,96-/m1/s1" RELATED InChI [UPa:] synonym: "lauroyl-KDO2-lipid IV(A)" EXACT [KEGG:KEGG] xref: CHEBI:27422 xref: KEGG:C06251 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06307 name: (-)-beta-pinene namespace: compound synonym: "beta-pinene" EXACT [KEGG:KEGG] synonym: "C10H16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H16/c1-7-4-5-8-6-9(7)10(8,2)3/h8-9H,1,4-6H2,2-3H3/t8-,9-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:28359 xref: KEGG:C06307 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06308 name: (-)-alpha-pinene namespace: compound synonym: "alpha-pinene" EXACT [KEGG:KEGG] synonym: "C10H16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H16/c1-7-4-5-8-6-9(7)10(8,2)3/h4,8-9H,5-6H2,1-3H3/t8-,9-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:28660 xref: KEGG:C06308 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06313 name: biopterin namespace: compound synonym: "C9H11N5O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h2-3,6,15-16H,1H3,(H3,10,11,13,14,17)" RELATED InChI [UPa:] xref: CHEBI:15373 xref: KEGG:C06313 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06316 name: dehydro-D-arabinono-1,4-lactone namespace: compound synonym: "C5H6O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-erythro-ascorbic acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C5H6O5/c6-1-2-3(7)4(8)5(9)10-2/h2,6-8H,1H2/t2-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17803 xref: KEGG:C06316 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06317 name: vanillyl-alcohol namespace: compound synonym: "C8H10O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H10O3/c1-11-8-4-6(5-9)2-3-7(8)10/h2-4,9-10H,5H2,1H3" RELATED InChI [UPa:] xref: CHEBI:18353 xref: KEGG:C06317 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06319 name: precorrin-6B namespace: compound synonym: "C44H56N4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C44H56N4O16/c1-40(13-12-34(55)56)25(15-36(59)60)39-44(5)42(3,20-38(63)64)23(8-11-33(53)54)27(48-44)17-30-41(2,19-37(61)62)22(7-10-32(51)52)28(45-30)18-43(4)24(14-35(57)58)21(6-9-31(49)50)26(47-43)16-29(40)46-39/h17,23,25,39,48H,6-16,18-20H2,1-5H3,(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H,61,62)(H,63,64)/b27-17-/t23-,25+,39?,40-,41+,42+,43+,44+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27858 xref: KEGG:C06319 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06320 name: precorrin-6A namespace: compound synonym: "C44H54N4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C44H54N4O16/c1-40(13-12-34(55)56)25(15-36(59)60)39-44(5)42(3,20-38(63)64)23(8-11-33(53)54)27(48-44)17-30-41(2,19-37(61)62)22(7-10-32(51)52)28(45-30)18-43(4)24(14-35(57)58)21(6-9-31(49)50)26(47-43)16-29(40)46-39/h17,23,48H,6-16,18-20H2,1-5H3,(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H,61,62)(H,63,64)/b27-17-/t23-,40-,41+,42+,43+,44+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27513 xref: KEGG:C06320 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06321 name: (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid namespace: compound synonym: "1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate" EXACT [KEGG:KEGG] synonym: "C7H8O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H8O4/c8-5-3-1-2-4-7(5,11)6(9)10/h1-5,8,11H,(H,9,10)/t5-,7+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18340 xref: CHEBI:37888 xref: KEGG:C06321 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06387 name: 4-chlorobenzoyl-CoA namespace: compound synonym: "C28H39ClN7O17P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C28H39ClN7O17P3S/c1-28(2,22(39)25(40)32-8-7-18(37)31-9-10-57-27(41)15-3-5-16(29)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)36-14-35-19-23(30)33-13-34-24(19)36/h3-6,13-14,17,20-22,26,38-39H,7-12H2,1-2H3,(H,31,37)(H,32,40)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/t17-,20-,21-,22+,26-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15498 xref: KEGG:C06387 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06397 name: ADP-D-glycero-beta-D-manno-heptose namespace: compound synonym: "C17H27N5O16P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C17H27N5O16P2/c18-14-7-15(20-3-19-14)22(4-21-7)16-11(28)8(25)6(35-16)2-34-39(30,31)38-40(32,33)37-17-12(29)9(26)10(27)13(36-17)5(24)1-23/h3-6,8-13,16-17,23-29H,1-2H2,(H,30,31)(H,32,33)(H2,18,19,20)/t5-,6-,8-,9+,10+,11-,12+,13-,16-,17+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16693 xref: KEGG:C06397 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06398 name: ADP-L-glycero-beta-D-manno-heptose namespace: compound synonym: "C17H27N5O16P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C17H27N5O16P2/c18-14-7-15(20-3-19-14)22(4-21-7)16-11(28)8(25)6(35-16)2-34-39(30,31)38-40(32,33)37-17-12(29)9(26)10(27)13(36-17)5(24)1-23/h3-6,8-13,16-17,23-29H,1-2H2,(H,30,31)(H,32,33)(H2,18,19,20)/t5-,6+,8+,9-,10-,11+,12-,13+,16+,17-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15915 xref: KEGG:C06398 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06399 name: hydrogenobyrinic acid namespace: compound synonym: "C45H60N4O14" RELATED FORMULA [KEGG:COMPOUND] synonym: "hydrogenobyrinate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C45H60N4O14/c1-21-36-24(10-13-30(52)53)41(3,4)28(47-36)18-27-23(9-12-29(50)51)43(6,19-34(60)61)39(46-27)22(2)37-25(11-14-31(54)55)44(7,20-35(62)63)45(8,49-37)40-26(17-33(58)59)42(5,38(21)48-40)16-15-32(56)57/h18,23-26,40,48H,9-17,19-20H2,1-8H3,(H,50,51)(H,52,53)(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H,62,63)/b28-18-,38-21-,39-22-/t23-,24-,25-,26+,40?,42-,43+,44+,45+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17926 xref: KEGG:C06399 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06406 name: precorrin-3B namespace: compound synonym: "C43H50N4O17" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C43H50N4O17/c1-40(17-37(60)61)23(6-10-33(52)53)28-15-27-21(12-35(56)57)19(4-8-31(48)49)25(44-27)14-26-20(5-9-32(50)51)22(13-36(58)59)39(46-26)42(3,63)43-41(2,18-38(62)64-43)24(7-11-34(54)55)29(47-43)16-30(40)45-28/h15-16,23-24,44,46-47,63H,4-14,17-18H2,1-3H3,(H,48,49)(H,50,51)(H,52,53)(H,54,55)(H,56,57)(H,58,59)(H,60,61)/b28-15-,29-16-/t23-,24-,40+,41+,42+,43-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27711 xref: KEGG:C06406 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06407 name: precorrin-4 namespace: compound synonym: "C44H52N4O17" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C44H52N4O17/c1-20(49)44-40-25(14-37(60)61)41(2,12-11-35(56)57)30(47-40)16-27-21(5-8-32(50)51)22(13-36(58)59)26(45-27)15-28-23(6-9-33(52)53)42(3,18-38(62)63)31(46-28)17-29(48-44)24(7-10-34(54)55)43(44,4)19-39(64)65/h17,24,45,48H,5-16,18-19H2,1-4H3,(H,50,51)(H,52,53)(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H,62,63)(H,64,65)/b29-17-/t24-,41-,42+,43+,44?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16430 xref: KEGG:C06407 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06408 name: precorrin-8X namespace: compound synonym: "C45H60N4O14" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C45H60N4O14/c1-21-36-24(9-12-29(50)51)23(3)44(7,48-36)18-28-25(10-13-30(52)53)42(5,19-34(60)61)39(46-28)22(2)37-26(11-14-31(54)55)43(6,20-35(62)63)45(8,49-37)40-27(17-33(58)59)41(4,38(21)47-40)16-15-32(56)57/h21,25-27,40H,9-20H2,1-8H3,(H,50,51)(H,52,53)(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H,62,63)/b39-22-/t21-,25+,26+,27-,40?,41+,42-,43-,44-,45-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:28629 xref: KEGG:C06408 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06416 name: precorrin-5 namespace: compound synonym: "C45H54N4O17" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C45H54N4O17/c1-21(50)45-40-26(15-37(61)62)41(2,13-12-35(57)58)30(47-40)16-27-22(6-9-32(51)52)25(14-36(59)60)44(5,48-27)18-29-23(7-10-33(53)54)42(3,19-38(63)64)31(46-29)17-28(49-45)24(8-11-34(55)56)43(45,4)20-39(65)66/h17,24,49H,6-16,18-20H2,1-5H3,(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H,61,62)(H,63,64)(H,65,66)/b28-17-/t24-,41-,42+,43+,44+,45?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27630 xref: KEGG:C06416 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06442 name: N(4)-acetyl-L-2,4-diaminobutyric acid namespace: compound synonym: "C6H12N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H12N2O3/c1-4(9)8-3-2-5(7)6(10)11/h5H,2-3,7H2,1H3,(H,8,9)(H,10,11)/t5-/m0/s1" RELATED InChI [UPa:] synonym: "N-acetyl-L-2,4-diaminobutyrate" EXACT [KEGG:KEGG] synonym: "N-gamma-Acetyldiaminobutyrate" EXACT [KEGG:KEGG] xref: CHEBI:7351 xref: KEGG:C06442 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06457 name: bialaphos namespace: compound synonym: "C11H22N3O6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H22N3O6P/c1-6(9(15)14-7(2)11(17)18)13-10(16)8(12)4-5-21(3,19)20/h6-8H,4-5,12H2,1-3H3,(H,13,16)(H,14,15)(H,17,18)(H,19,20)/t6-,7-,8-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:3088 xref: KEGG:C06457 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06481 name: L-seryl-tRNA(Sec) namespace: compound xref: CHEBI:13170 xref: CHEBI:74589 xref: KEGG:C06481 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06482 name: selenocysteinyl-tRNA(Sec) namespace: compound xref: CHEBI:13166 xref: KEGG:C06482 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06503 name: hydrogenobyrinic acid a,c-diamide namespace: compound synonym: "C45H62N6O12" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C45H62N6O12/c1-21-36-24(10-13-32(56)57)41(3,4)28(49-36)18-27-23(9-12-31(54)55)43(6,19-29(46)52)39(48-27)22(2)37-25(11-14-33(58)59)44(7,20-30(47)53)45(8,51-37)40-26(17-35(62)63)42(5,38(21)50-40)16-15-34(60)61/h18,23-26,40,50H,9-17,19-20H2,1-8H3,(H2,46,52)(H2,47,53)(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H,62,63)/b28-18-,38-21-,39-22-/t23-,24-,25-,26+,40?,42-,43+,44+,45+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27914 xref: KEGG:C06503 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06504 name: cob(II)yrinate a,c-diamide namespace: compound synonym: "C45H61CoN6O12" RELATED FORMULA [KEGG:COMPOUND] synonym: "cob(II)yrinic acid a,c-diamide" EXACT [KEGG:KEGG] synonym: "InChI=1S/C45H62N6O12.Co/c1-21-36-24(10-13-32(56)57)41(3,4)28(49-36)18-27-23(9-12-31(54)55)43(6,19-29(46)52)39(48-27)22(2)37-25(11-14-33(58)59)44(7,20-30(47)53)45(8,51-37)40-26(17-35(62)63)42(5,38(21)50-40)16-15-34(60)61;/h18,23-26,40H,9-17,19-20H2,1-8H3,(H10,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63);/q;+2/p-1/t23-,24-,25-,26+,40-,42-,43+,44+,45+;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:27937 xref: KEGG:C06504 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06505 name: cob(I)yrinic acid a,c-diamide namespace: compound synonym: "C45H61CoN6O12" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C45H62N6O12.Co/c1-21-36-24(10-13-32(56)57)41(3,4)28(49-36)18-27-23(9-12-31(54)55)43(6,19-29(46)52)39(48-27)22(2)37-25(11-14-33(58)59)44(7,20-30(47)53)45(8,51-37)40-26(17-35(62)63)42(5,38(21)50-40)16-15-34(60)61;/h18,23-26,40H,9-17,19-20H2,1-8H3,(H10,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63);/q;+1/p-1/t23-,24-,25-,26+,40?,42-,43+,44+,45+;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:28531 xref: KEGG:C06505 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06506 name: adenosylcob(III)yrinic acid a,c-diamide namespace: compound synonym: "adenosyl cobyrinate a,c diamide" EXACT [KEGG:KEGG] synonym: "C55H73CoN11O15" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C45H62N6O12.C10H12N5O3.Co/c1-21-36-24(10-13-32(56)57)41(3,4)28(49-36)18-27-23(9-12-31(54)55)43(6,19-29(46)52)39(48-27)22(2)37-25(11-14-33(58)59)44(7,20-30(47)53)45(8,51-37)40-26(17-35(62)63)42(5,38(21)50-40)16-15-34(60)61;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h18,23-26,40H,9-17,19-20H2,1-8H3,(H10,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-1/t23-,24-,25-,26+,40?,42-,43+,44+,45+;4-,6-,7-,10-;/m11./s1" RELATED InChI [UPa:] xref: CHEBI:2482 xref: KEGG:C06506 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06507 name: adenosylcobyrinic acid a,c-diamide namespace: compound synonym: "C55H77CoN15O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C45H66N10O8.C10H12N5O3.Co/c1-21-36-24(10-13-30(47)57)41(3,4)28(53-36)18-27-23(9-12-29(46)56)43(6,19-33(50)60)39(52-27)22(2)37-25(11-14-31(48)58)44(7,20-34(51)61)45(8,55-37)40-26(17-32(49)59)42(5,38(21)54-40)16-15-35(62)63;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h18,23-26,40H,9-17,19-20H2,1-8H3,(H14,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-1/t23-,24-,25-,26+,40?,42-,43+,44+,45+;4-,6-,7-,10-;/m11./s1" RELATED InChI [UPa:] xref: CHEBI:2483 xref: KEGG:C06507 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06508 name: adenosylcobinamide namespace: compound synonym: "C58H84CoN16O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C48H73N11O8.C10H12N5O3.Co/c1-23(60)22-55-38(67)16-17-45(6)29(18-35(52)64)43-48(9)47(8,21-37(54)66)28(12-15-34(51)63)40(59-48)25(3)42-46(7,20-36(53)65)26(10-13-32(49)61)30(56-42)19-31-44(4,5)27(11-14-33(50)62)39(57-31)24(2)41(45)58-43;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h19,23,26-29,43,60H,10-18,20-22H2,1-9H3,(H14,49,50,51,52,53,54,55,56,57,58,59,61,62,63,64,65,66,67);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-1/t23-,26-,27-,28-,29+,43?,45-,46+,47+,48+;4-,6-,7-,10-;/m11./s1" RELATED InChI [UPa:] xref: CHEBI:2480 xref: KEGG:C06508 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06509 name: adenosylcobinamide phosphate namespace: compound synonym: "C58H85CoN16O14P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C48H74N11O11P.C10H12N5O3.Co/c1-23(70-71(67,68)69)22-55-38(66)16-17-45(6)29(18-35(52)63)43-48(9)47(8,21-37(54)65)28(12-15-34(51)62)40(59-48)25(3)42-46(7,20-36(53)64)26(10-13-32(49)60)30(56-42)19-31-44(4,5)27(11-14-33(50)61)39(57-31)24(2)41(45)58-43;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h19,23,26-29,43H,10-18,20-22H2,1-9H3,(H16,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-1/t23-,26-,27-,28-,29+,43?,45-,46+,47+,48+;4-,6-,7-,10-;/m11./s1" RELATED InChI [UPa:] xref: CHEBI:2481 xref: KEGG:C06509 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06510 name: adenosylcobinamide-GDP namespace: compound synonym: "C68H97CoN21O21P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C58H86N16O18P2.C10H12N5O3.Co/c1-25(91-94(87,88)92-93(85,86)89-23-33-45(82)46(83)52(90-33)74-24-67-44-50(74)71-53(65)72-51(44)84)22-66-41(81)16-17-55(6)31(18-38(62)78)49-58(9)57(8,21-40(64)80)30(12-15-37(61)77)43(73-58)27(3)48-56(7,20-39(63)79)28(10-13-35(59)75)32(68-48)19-34-54(4,5)29(11-14-36(60)76)42(69-34)26(2)47(55)70-49;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h19,24-25,28-31,33,45-46,49,52,82-83H,10-18,20-23H2,1-9H3,(H19,59,60,61,62,63,64,65,66,68,69,70,71,72,73,75,76,77,78,79,80,81,84,85,86,87,88);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-1/t25-,28-,29-,30-,31+,33-,45-,46-,49?,52-,55-,56+,57+,58+;4-,6-,7-,10-;/m11./s1" RELATED InChI [UPa:] xref: CHEBI:2479 xref: KEGG:C06510 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06542 name: ajmaline namespace: compound synonym: "C20H26N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C20H26N2O2/c1-3-10-11-8-14-17-20(12-6-4-5-7-13(12)21(17)2)9-15(16(11)18(20)23)22(14)19(10)24/h4-7,10-11,14-19,23-24H,3,8-9H2,1-2H3/t10-,11-,14?,15-,16?,17-,18+,19+,20+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:28462 xref: KEGG:C06542 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06547 name: ethylene namespace: compound synonym: "C2H4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H4/c1-2/h1-2H2" RELATED InChI [UPa:] xref: CHEBI:18153 xref: KEGG:C06547 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06551 name: atrazine namespace: compound synonym: "C8H14ClN5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H14ClN5/c1-4-10-7-12-6(9)13-8(14-7)11-5(2)3/h5H,4H2,1-3H3,(H2,10,11,12,13,14)" RELATED InChI [UPa:] xref: CHEBI:15930 xref: KEGG:C06551 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06552 name: hydroxyatrazine namespace: compound synonym: "C8H15N5O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H15N5O/c1-4-9-6-11-7(10-5(2)3)13-8(14)12-6/h5H,4H2,1-3H3,(H3,9,10,11,12,13,14)" RELATED InChI [UPa:] xref: CHEBI:18316 xref: KEGG:C06552 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06553 name: N-isopropylammelide namespace: compound synonym: "C6H10N4O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10N4O2/c1-3(2)7-4-8-5(11)10-6(12)9-4/h3H,1-2H3,(H3,7,8,9,10,11,12)" RELATED InChI [UPa:] xref: CHEBI:17247 xref: KEGG:C06553 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06554 name: cyanurate namespace: compound synonym: "C3H3N3O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "cyanuric acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C3H3N3O3/c7-1-4-2(8)6-3(9)5-1/h(H3,4,5,6,7,8,9)" RELATED InChI [UPa:] xref: CHEBI:38028 xref: KEGG:C06554 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06555 name: biuret namespace: compound synonym: "C2H5N3O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H5N3O2/c3-1(6)5-2(4)7/h(H5,3,4,5,6,7)" RELATED InChI [UPa:] xref: CHEBI:18138 xref: KEGG:C06555 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06566 name: cephamycin C namespace: compound synonym: "C16H22N4O9S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C16H22N4O9S/c1-28-16(19-9(21)4-2-3-8(17)11(22)23)13(26)20-10(12(24)25)7(5-29-15(18)27)6-30-14(16)20/h8,14H,2-6,17H2,1H3,(H2,18,27)(H,19,21)(H,22,23)(H,24,25)/t8-,14-,16+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:3543 xref: KEGG:C06566 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06578 name: p-cumate namespace: compound synonym: "C10H12O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H12O2/c1-7(2)8-3-5-9(6-4-8)10(11)12/h3-7H,1-2H3,(H,11,12)" RELATED InChI [UPa:] synonym: "p-cumic acid" EXACT [KEGG:KEGG] xref: CHEBI:25822 xref: CHEBI:28122 xref: KEGG:C06578 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06579 name: cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid namespace: compound synonym: "C10H14O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "cis-2,3-dihydroxy-2,3-dihydro-p-cumate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C10H14O4/c1-5(2)6-3-4-7(10(13)14)9(12)8(6)11/h3-5,8-9,11-12H,1-2H3,(H,13,14)/t8-,9+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18242 xref: KEGG:C06579 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06580 name: 2,3-dihydroxy-p-cumic acid namespace: compound synonym: "2,3-dihydroxy-p-cumate" EXACT [KEGG:KEGG] synonym: "C10H12O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H12O4/c1-5(2)6-3-4-7(10(13)14)9(12)8(6)11/h3-5,11-12H,1-2H3,(H,13,14)" RELATED InChI [UPa:] xref: CHEBI:16725 xref: CHEBI:36647 xref: KEGG:C06580 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06581 name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid namespace: compound synonym: "2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate" EXACT [KEGG:KEGG] synonym: "C10H12O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H12O6/c1-5(2)7(11)4-3-6(9(13)14)8(12)10(15)16/h3-5,12H,1-2H3,(H,13,14)(H,15,16)/b4-3-,8-6-" RELATED InChI [UPa:] xref: CHEBI:79383 xref: KEGG:C06581 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06582 name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid namespace: compound synonym: "2-hydroxy-6-oxo-7-methylocta-2,4-dienoate" EXACT [KEGG:KEGG] synonym: "C9H12O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H12O4/c1-6(2)7(10)4-3-5-8(11)9(12)13/h3-6,11H,1-2H3,(H,12,13)/b4-3-,8-5+" RELATED InChI [UPa:] xref: CHEBI:28961 xref: KEGG:C06582 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06588 name: biphenyl namespace: compound synonym: "C12H10" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H10/c1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H" RELATED InChI [UPa:] xref: CHEBI:17097 xref: KEGG:C06588 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06589 name: cis-3-phenylcyclohexa-3,5-diene-1,2-diol namespace: compound synonym: "(1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol" EXACT [KEGG:KEGG] synonym: "C12H12O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H12O2/c13-11-8-4-7-10(12(11)14)9-5-2-1-3-6-9/h1-8,11-14H/t11-,12+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15599 xref: CHEBI:32922 xref: KEGG:C06589 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06609 name: trans-1,3-dichloropropene namespace: compound synonym: "C3H4Cl2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H4Cl2/c4-2-1-3-5/h1-2H,3H2/b2-1+" RELATED InChI [UPa:] xref: CHEBI:18624 xref: KEGG:C06609 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06610 name: cis-1,3-dichloropropene namespace: compound synonym: "C3H4Cl2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H4Cl2/c4-2-1-3-5/h1-2H,3H2/b2-1-" RELATED InChI [UPa:] xref: CHEBI:18809 xref: KEGG:C06610 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06611 name: trans-3-chloro-2-propene-1-ol namespace: compound synonym: "C3H5ClO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H5ClO/c4-2-1-3-5/h1-2,5H,3H2/b2-1+" RELATED InChI [UPa:] xref: CHEBI:28960 xref: KEGG:C06611 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06612 name: cis-3-Chloro-2-propene-1-ol namespace: compound synonym: "C3H5ClO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H5ClO/c4-2-1-3-5/h1-2,5H,3H2/b2-1-" RELATED InChI [UPa:] xref: CHEBI:28967 xref: KEGG:C06612 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06613 name: 3-chloroallyl aldehyde namespace: compound synonym: "C3H3ClO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H3ClO/c4-2-1-3-5/h1-3H/b2-1+" RELATED InChI [UPa:] xref: CHEBI:28452 xref: KEGG:C06613 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06614 name: trans-3-chloroacrylic acid namespace: compound synonym: "C3H3ClO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H3ClO2/c4-2-1-3(5)6/h1-2H,(H,5,6)/b2-1+" RELATED InChI [UPa:] xref: CHEBI:19982 xref: CHEBI:28404 xref: KEGG:C06614 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06615 name: cis-3-chloroacrylic acid namespace: compound synonym: "C3H3ClO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H3ClO2/c4-2-1-3(5)6/h1-2H,(H,5,6)/b2-1-" RELATED InChI [UPa:] xref: CHEBI:27397 xref: KEGG:C06615 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06655 name: N(2)-(2-carboxyethyl)-L-arginine namespace: compound synonym: "C9H18N4O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H18N4O4/c10-9(11)13-4-1-2-6(8(16)17)12-5-3-7(14)15/h6,12H,1-5H2,(H,14,15)(H,16,17)(H4,10,11,13)/t6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15427 xref: KEGG:C06655 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06656 name: deoxyamidinoproclavaminic acid namespace: compound synonym: "C9H16N4O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "deoxyamidinoproclavaminate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C9H16N4O3/c10-9(11)12-4-1-2-6(8(15)16)13-5-3-7(13)14/h6H,1-5H2,(H,15,16)(H4,10,11,12)/t6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15426 xref: KEGG:C06656 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06657 name: amidinoproclavaminic acid namespace: compound synonym: "amidinoproclavaminate" EXACT [KEGG:KEGG] synonym: "C9H16N4O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H16N4O4/c10-9(11)12-3-1-5(14)7(8(16)17)13-4-2-6(13)15/h5,7,14H,1-4H2,(H,16,17)(H4,10,11,12)/t5-,7+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:32963 xref: KEGG:C06657 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06658 name: proclavaminic acid namespace: compound synonym: "C8H14N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H14N2O4/c9-3-1-5(11)7(8(13)14)10-4-2-6(10)12/h5,7,11H,1-4,9H2,(H,13,14)/t5-,7+/m1/s1" RELATED InChI [UPa:] synonym: "proclavaminate" EXACT [KEGG:KEGG] xref: CHEBI:15425 xref: KEGG:C06658 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06659 name: dihydroclavaminic acid namespace: compound synonym: "C8H12N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "dihydroclavaminate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C8H12N2O4/c9-2-1-4-7(8(12)13)10-5(11)3-6(10)14-4/h4,6-7H,1-3,9H2,(H,12,13)/t4-,6+,7+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15424 xref: KEGG:C06659 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06660 name: clavaminate namespace: compound synonym: "C8H10N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H10N2O4/c9-2-1-4-7(8(12)13)10-5(11)3-6(10)14-4/h1,6-7H,2-3,9H2,(H,12,13)/b4-1-/t6-,7-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15423 xref: KEGG:C06660 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06661 name: clavulanate-9-aldehyde namespace: compound synonym: "C8H7NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H7NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1-2,6-7H,3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27819 xref: KEGG:C06661 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06662 name: clavulanate namespace: compound synonym: "C8H9NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "clavulanic acid" EXACT [KEGG:KEGG] synonym: "InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:48947 xref: KEGG:C06662 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06669 name: carbapenem namespace: compound synonym: "C7H7NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H7NO3/c9-6-3-4-1-2-5(7(10)11)8(4)6/h2,4H,1,3H2,(H,10,11)/t4-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:615 xref: KEGG:C06669 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06689 name: vancomycin namespace: compound synonym: "C66H75Cl2N9O24" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:28001 xref: KEGG:C06689 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06690 name: candicidin namespace: compound synonym: "C59H84N2O18" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C59H84N2O18/c1-35-18-15-13-11-9-7-5-6-8-10-12-14-16-21-46(77-58-55(72)53(61)54(71)38(4)76-58)31-50-52(57(73)74)49(69)34-59(75,79-50)33-45(66)29-44(65)28-43(64)27-41(62)19-17-20-42(63)30-51(70)78-56(35)37(3)26-36(2)47(67)32-48(68)39-22-24-40(60)25-23-39/h5-16,18,21-25,35-38,43-47,49-50,52-56,58,64-67,69,71-72,75H,17,19-20,26-34,60-61H2,1-4H3,(H,73,74)/b6-5+,9-7+,10-8+,13-11+,14-12+,18-15+,21-16+/t35?,36?,37?,38-,43?,44?,45?,46?,47?,49?,50?,52?,53+,54-,55+,56?,58?,59?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:3349 xref: KEGG:C06690 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06691 name: actinorhodin namespace: compound synonym: "C32H26O14" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C32H26O14/c1-9-21-15(3-11(45-9)5-19(35)36)29(41)23-17(33)7-13(27(39)25(23)31(21)43)14-8-18(34)24-26(28(14)40)32(44)22-10(2)46-12(6-20(37)38)4-16(22)30(24)42/h7-12,33-34,39-40H,3-6H2,1-2H3,(H,35,36)(H,37,38)/t9-,10-,11+,12+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:2448 xref: KEGG:C06691 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06693 name: monensin namespace: compound synonym: "C36H62O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C36H62O11/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40)/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35+,36-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:27617 xref: KEGG:C06693 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06735 name: aminoacetaldehyde namespace: compound synonym: "C2H5NO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H5NO/c3-1-2-4/h2H,1,3H2" RELATED InChI [UPa:] xref: CHEBI:17628 xref: KEGG:C06735 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06748 name: isopropylamine namespace: compound synonym: "C3H9N" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H9N/c1-3(2)4/h3H,4H2,1-2H3" RELATED InChI [UPa:] xref: CHEBI:15739 xref: KEGG:C06748 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06752 name: 1,2-dichloroethane namespace: compound synonym: "C2H4Cl2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H4Cl2/c3-1-2-4/h1-2H2" RELATED InChI [UPa:] xref: CHEBI:27789 xref: KEGG:C06752 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06753 name: 2-chloroethanol namespace: compound synonym: "C2H5ClO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H5ClO/c3-1-2-4/h4H,1-2H2" RELATED InChI [UPa:] xref: CHEBI:28200 xref: KEGG:C06753 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06754 name: chloroacetaldehyde namespace: compound synonym: "C2H3ClO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H3ClO/c3-1-2-4/h2H,1H2" RELATED InChI [UPa:] xref: CHEBI:27871 xref: KEGG:C06754 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06755 name: chloroacetic acid namespace: compound synonym: "C2H3ClO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "chloroacetate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C2H3ClO2/c3-1-2(4)5/h1H2,(H,4,5)" RELATED InChI [UPa:] xref: CHEBI:27869 xref: KEGG:C06755 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06769 name: vibriobactin namespace: compound synonym: "C35H39N5O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C35H39N5O11/c1-18-26(38-33(50-18)21-9-4-12-24(42)29(21)45)32(48)37-15-7-17-40(16-6-14-36-31(47)20-8-3-11-23(41)28(20)44)35(49)27-19(2)51-34(39-27)22-10-5-13-25(43)30(22)46/h3-5,8-13,18-19,26-27,41-46H,6-7,14-17H2,1-2H3,(H,36,47)(H,37,48)/t18-,19+,26+,27-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:9973 xref: KEGG:C06769 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06799 name: granaticin namespace: compound synonym: "C22H20O10" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C22H20O10/c1-5-11-15(21-8(30-5)4-10(24)32-21)19(27)13-14(17(11)25)20(28)16-12(18(13)26)7-3-9(23)22(16,29)6(2)31-7/h5-9,21,23,26,28-29H,3-4H2,1-2H3/t5-,6+,7+,8-,9+,21+,22+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:5533 xref: KEGG:C06799 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06801 name: tetracenomycin C namespace: compound synonym: "C23H20O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C23H20O11/c1-8-14-9(6-11(32-2)15(8)21(29)34-4)5-10-16(17(14)25)20(28)22(30)13(24)7-12(33-3)19(27)23(22,31)18(10)26/h5-7,19,25,27,30-31H,1-4H3/t19-,22-,23-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:9470 xref: KEGG:C06801 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06812 name: lincomycin namespace: compound synonym: "C18H34N2O6S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:6472 xref: KEGG:C06812 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06891 name: D-2,3-dioxo-4-deoxy-epi-inositol namespace: compound synonym: "C6H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-2,3-diketo 4-deoxy-epi-inositol" EXACT [KEGG:KEGG] synonym: "InChI=1S/C6H8O5/c7-2-1-3(8)5(10)6(11)4(2)9/h1-2,4,6-9,11H/t2-,4+,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:4077 xref: KEGG:C06891 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06892 name: 2-deoxy-5-keto-D-gluconic acid namespace: compound synonym: "C6H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O6/c7-2-4(9)6(12)3(8)1-5(10)11/h3,6-8,12H,1-2H2,(H,10,11)/t3-,6+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27972 xref: KEGG:C06892 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC06893 name: 6-phospho-5-dehydro-2-deoxy-D-gluconic acid namespace: compound synonym: "2-deoxy-5-keto-D-gluconic acid 6-phosphate" EXACT [KEGG:KEGG] synonym: "C6H11O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H11O9P/c7-3(1-5(9)10)6(11)4(8)2-15-16(12,13)14/h3,6-7,11H,1-2H2,(H,9,10)(H2,12,13,14)/t3-,6+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16925 xref: KEGG:C06893 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07086 name: phenylacetate namespace: compound synonym: "C8H8O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:30745 xref: KEGG:C07086 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07100 name: (2,4,5-trichlorophenoxy)acetate namespace: compound synonym: "C8H5Cl3O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H5Cl3O3/c9-4-1-6(11)7(2-5(4)10)14-3-8(12)13/h1-2H,3H2,(H,12,13)" RELATED InChI [UPa:] xref: CHEBI:27903 xref: KEGG:C07100 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07271 name: (4R)-limonene 1,2-epoxide namespace: compound synonym: "C10H16O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H16O/c1-7(2)8-4-5-10(3)9(6-8)11-10/h8-9H,1,4-6H2,2-3H3/t8-,9?,10?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:35672 xref: KEGG:C07271 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07276 name: (1S,2S,4R)-limonene-1,2-diol namespace: compound synonym: "C10H18O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H18O2/c1-7(2)8-4-5-10(3,12)9(11)6-8/h8-9,11-12H,1,4-6H2,2-3H3/t8-,9+,10+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17219 xref: CHEBI:18515 xref: KEGG:C07276 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07335 name: 2-amino-3-oxo-4-phosphonooxybutyrate namespace: compound synonym: "C4H8NO7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H8NO7P/c5-3(4(7)8)2(6)1-12-13(9,10)11/h3H,1,5H2,(H,7,8)(H2,9,10,11)/t3-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:64186 xref: KEGG:C07335 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07394 name: taxol namespace: compound synonym: "C47H51NO14" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38?,40-,45+,46-,47+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:45863 xref: KEGG:C07394 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07729 name: dibenzofuran namespace: compound synonym: "C12H8O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H8O/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11/h1-8H" RELATED InChI [UPa:] xref: CHEBI:28145 xref: KEGG:C07729 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07731 name: 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid namespace: compound synonym: "2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoic acid" EXACT [KEGG:KEGG] synonym: "C12H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H10O5/c13-9-5-2-1-4-8(9)10(14)6-3-7-11(15)12(16)17/h1-7,13,15H,(H,16,17)/b6-3-,11-7+" RELATED InChI [UPa:] xref: CHEBI:1135 xref: CHEBI:36538 xref: KEGG:C07731 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07732 name: dibenzo-p-dioxin namespace: compound synonym: "C12H8O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H8O2/c1-2-6-10-9(5-1)13-11-7-3-4-8-12(11)14-10/h1-8H" RELATED InChI [UPa:] xref: CHEBI:28891 xref: KEGG:C07732 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07733 name: 2,2',3-trihydroxy-diphenyl ether namespace: compound synonym: "2,2',3-trihydroxydiphenylether" EXACT [KEGG:KEGG] synonym: "C12H10O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H10O4/c13-8-4-1-2-6-10(8)16-11-7-3-5-9(14)12(11)15/h1-7,13-15H" RELATED InChI [UPa:] xref: CHEBI:27381 xref: KEGG:C07733 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07734 name: 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid namespace: compound synonym: "2-hydroxy-6-oxo-6-(2-hydroxyphenoxy)-hexa-2,4-dienoic acid" EXACT [KEGG:KEGG] synonym: "C12H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H10O6/c13-8-4-1-2-6-10(8)18-11(15)7-3-5-9(14)12(16)17/h1-7,13-14H,(H,16,17)/b7-3-,9-5+" RELATED InChI [UPa:] xref: CHEBI:19327 xref: CHEBI:28990 xref: KEGG:C07734 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07836 name: D-glycero-beta-D-manno-heptose 7-phosphate namespace: compound synonym: "C7H15O10P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H15O10P/c8-2(1-16-18(13,14)15)6-4(10)3(9)5(11)7(12)17-6/h2-12H,1H2,(H2,13,14,15)/t2-,3+,4+,5+,6-,7-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28723 xref: KEGG:C07836 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC07838 name: D-glycero-beta-D-manno-heptose 1-phosphate namespace: compound synonym: "C7H15O10P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H15O10P/c8-1-2(9)6-4(11)3(10)5(12)7(16-6)17-18(13,14)15/h2-12H,1H2,(H2,13,14,15)/t2-,3+,4+,5+,6-,7+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:28137 xref: KEGG:C07838 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC08060 name: carbazole namespace: compound synonym: "C12H9N" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H9N/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11/h1-8,13H" RELATED InChI [UPa:] xref: CHEBI:27543 xref: CHEBI:3391 xref: KEGG:C08060 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC08215 name: thyroid hormone namespace: compound xref: CHEBI:9584 xref: KEGG:C08215 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC08353 name: beta-D-ribopyranose namespace: compound synonym: "C5H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10O5/c6-2-1-10-5(9)4(8)3(2)7/h2-9H,1H2/t2-,3-,4-,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27476 xref: KEGG:C08353 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC08579 name: antheraxanthin namespace: compound synonym: "C40H56O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H56O3/c1-29(17-13-19-31(3)21-22-36-33(5)25-34(41)26-37(36,6)7)15-11-12-16-30(2)18-14-20-32(4)23-24-40-38(8,9)27-35(42)28-39(40,10)43-40/h11-24,34-35,41-42H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,22-21+,24-23+,29-15+,30-16+,31-19+,32-20+/t34-,35+,39-,40+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:27867 xref: KEGG:C08579 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC08580 name: astaxanthin namespace: compound synonym: "C40H52O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:40968 xref: KEGG:C08580 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC08584 name: capsanthin namespace: compound synonym: "C40H56O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H56O3/c1-29(17-13-19-31(3)21-23-36-33(5)25-34(41)26-38(36,6)7)15-11-12-16-30(2)18-14-20-32(4)22-24-37(43)40(10)28-35(42)27-39(40,8)9/h11-24,34-35,41-42H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t34-,35+,40+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:3375 xref: KEGG:C08584 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC08585 name: capsorubin namespace: compound synonym: "C40H56O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H56O4/c1-29(17-13-19-31(3)21-23-35(43)39(9)27-33(41)25-37(39,5)6)15-11-12-16-30(2)18-14-20-32(4)22-24-36(44)40(10)28-34(42)26-38(40,7)8/h11-24,33-34,41-42H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t33-,34-,39-,40-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:3378 xref: KEGG:C08585 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC08606 name: neoxanthin namespace: compound synonym: "C40H56O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H56O4/c1-29(17-13-19-31(3)21-22-35-36(5,6)25-33(41)27-38(35,9)43)15-11-12-16-30(2)18-14-20-32(4)23-24-40-37(7,8)26-34(42)28-39(40,10)44-40/h11-21,23-24,33-34,41-43H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,24-23+,29-15+,30-16+,31-19+,32-20+/t22?,33-,34-,38+,39+,40-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:25501 xref: CHEBI:32446 xref: KEGG:C08606 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC08614 name: violaxanthin namespace: compound synonym: "C40H56O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H56O4/c1-29(17-13-19-31(3)21-23-39-35(5,6)25-33(41)27-37(39,9)43-39)15-11-12-16-30(2)18-14-20-32(4)22-24-40-36(7,8)26-34(42)28-38(40,10)44-40/h11-24,33-34,41-42H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t33-,34-,37+,38+,39-,40-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:35288 xref: KEGG:C08614 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC08737 name: melamine namespace: compound synonym: "C3H6N6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H6N6/c4-1-7-2(5)9-3(6)8-1/h(H6,4,5,6,7,8,9)" RELATED InChI [UPa:] xref: CHEBI:27915 xref: KEGG:C08737 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC09244 name: tabersonine namespace: compound synonym: "C21H24N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C21H24N2O2/c1-3-20-9-6-11-23-12-10-21(19(20)23)15-7-4-5-8-16(15)22-17(21)14(13-20)18(24)25-2/h4-9,19,22H,3,10-13H2,1-2H3/t19-,20-,21-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:16776 xref: KEGG:C09244 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC09844 name: 1,8-cineole namespace: compound synonym: "C10H18O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3" RELATED InChI [UPa:] xref: CHEBI:27961 xref: KEGG:C09844 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC10172 name: stachydrine namespace: compound synonym: "C7H13NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H13NO2/c1-8(2)5-3-4-6(8)7(9)10/h6H,3-5H2,1-2H3/t6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:35280 xref: KEGG:C10172 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11020 name: 2-(2,4-dichlorophenoxy)propanoate namespace: compound synonym: "(2,4-dichlorophenoxy)propanoate" EXACT [KEGG:KEGG] synonym: "C9H8Cl2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H8Cl2O3/c1-5(9(12)13)14-8-3-2-6(10)4-7(8)11/h2-5H,1H3,(H,12,13)" RELATED InChI [UPa:] xref: CHEBI:75370 xref: CHEBI:75375 xref: KEGG:C11020 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11088 name: 1,2-dibromoethane namespace: compound synonym: "C2H4Br2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C2H4Br2/c3-1-2-4/h1-2H2" RELATED InChI [UPa:] xref: CHEBI:28534 xref: KEGG:C11088 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11130 name: 3-hydroxyindolin-2-one namespace: compound synonym: "C8H7NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H7NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4,7,10H,(H,9,11)" RELATED InChI [UPa:] xref: CHEBI:28536 xref: KEGG:C11130 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11218 name: gramicidin S namespace: compound synonym: "C60H92N12O10" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C60H92N12O10/c1-35(2)31-43-53(75)67-45(33-39-19-11-9-12-20-39)59(81)71-29-17-25-47(71)55(77)70-50(38(7)8)58(80)64-42(24-16-28-62)52(74)66-44(32-36(3)4)54(76)68-46(34-40-21-13-10-14-22-40)60(82)72-30-18-26-48(72)56(78)69-49(37(5)6)57(79)63-41(23-15-27-61)51(73)65-43/h9-14,19-22,35-38,41-50H,15-18,23-34,61-62H2,1-8H3,(H,63,79)(H,64,80)(H,65,73)(H,66,74)(H,67,75)(H,68,76)(H,69,78)(H,70,77)/t41-,42-,43-,44-,45+,46+,47-,48-,49-,50-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:5530 xref: KEGG:C11218 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11355 name: 4-amino-4-deoxychorismate namespace: compound synonym: "C10H11NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H11NO5/c1-5(9(12)13)16-8-4-6(10(14)15)2-3-7(8)11/h2-4,7-8H,1,11H2,(H,12,13)(H,14,15)/t7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18198 xref: CHEBI:35181 xref: KEGG:C11355 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11383 name: (S)-carvone namespace: compound synonym: "C10H14O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15399 xref: KEGG:C11383 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11409 name: (4S,6R)-trans-carveol namespace: compound synonym: "C10H16O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H16O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9-11H,1,5-6H2,2-3H3/t9-,10+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15388 xref: KEGG:C11409 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11412 name: (1R,4S)-isodihydrocarvone namespace: compound synonym: "(1R,4S)-iso-dihydrocarvone" EXACT [KEGG:KEGG] synonym: "C10H16O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H16O/c1-7(2)9-5-4-8(3)10(11)6-9/h8-9H,1,4-6H2,2-3H3/t8-,9+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:155 xref: KEGG:C11412 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11434 name: 2-C-methyl-D-erythritol 4-phosphate namespace: compound synonym: "C5H13O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H13O7P/c1-5(8,3-6)4(7)2-12-13(9,10)11/h4,6-8H,2-3H2,1H3,(H2,9,10,11)/t4-,5+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17764 xref: KEGG:C11434 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11435 name: 4-CDP-2-C-methyl-D-erythritol namespace: compound synonym: "4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol" EXACT [KEGG:KEGG] synonym: "C14H25N3O14P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H25N3O14P2/c1-14(23,6-18)8(19)5-29-33(26,27)31-32(24,25)28-4-7-10(20)11(21)12(30-7)17-3-2-9(15)16-13(17)22/h2-3,7-8,10-12,18-21,23H,4-6H2,1H3,(H,24,25)(H,26,27)(H2,15,16,22)/t7-,8-,10-,11-,12-,14+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16578 xref: KEGG:C11435 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11436 name: 4-CDP-2-C-methyl-D-erythritol 2-phosphate namespace: compound synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol" EXACT [KEGG:KEGG] synonym: "C14H26N3O17P3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H26N3O17P3/c1-14(6-18,33-35(23,24)25)8(19)5-31-37(28,29)34-36(26,27)30-4-7-10(20)11(21)12(32-7)17-3-2-9(15)16-13(17)22/h2-3,7-8,10-12,18-21H,4-6H2,1H3,(H,26,27)(H,28,29)(H2,15,16,22)(H2,23,24,25)/t7-,8-,10-,11-,12-,14+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16840 xref: KEGG:C11436 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11437 name: 1-deoxy-D-xylulose 5-phosphate namespace: compound synonym: "C5H11O7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11O7P/c1-3(6)5(8)4(7)2-12-13(9,10)11/h4-5,7-8H,2H2,1H3,(H2,9,10,11)/t4-,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16493 xref: KEGG:C11437 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11453 name: 2-C-methyl-D-erythritol 2,4-cyclic diphosphate namespace: compound synonym: "2-C-methyl-D-erythritol 2,4-cyclodiphophate" EXACT [KEGG:KEGG] synonym: "C5H12O9P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H12O9P2/c1-5(3-6)4(7)2-12-15(8,9)14-16(10,11)13-5/h4,6-7H,2-3H2,1H3,(H,8,9)(H,10,11)/t4-,5+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:18425 xref: KEGG:C11453 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11455 name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol namespace: compound synonym: "C29H46O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:17813 xref: KEGG:C11455 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11457 name: 3-(3-hydroxyphenyl)propanoate namespace: compound synonym: "3-(3-hydroxyphenyl)propionic acid" EXACT [KEGG:KEGG] synonym: "C9H10O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H10O3/c10-8-3-1-2-7(6-8)4-5-9(11)12/h1-3,6,10H,4-5H2,(H,11,12)" RELATED InChI [UPa:] xref: CHEBI:1427 xref: KEGG:C11457 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11472 name: D-glycero-beta-D-manno-heptose 1,7-diphosphate namespace: compound synonym: "C7H16O13P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-glycero-beta-D-manno-heptose 1,7-bisphosphate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C7H16O13P2/c8-2(1-18-21(12,13)14)6-4(10)3(9)5(11)7(19-6)20-22(15,16)17/h2-11H,1H2,(H2,12,13,14)(H2,15,16,17)/t2-,3+,4+,5+,6-,7+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:4188 xref: KEGG:C11472 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11482 name: holo-Lys2 namespace: compound xref: CHEBI:5743 xref: KEGG:C11482 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11516 name: 2-(alpha-D-mannosyl)-3-phosphoglyceric acid namespace: compound synonym: "2-(alpha-D-mannosyl)-3-phosphoglycerate" EXACT [KEGG:KEGG] synonym: "C9H17O12P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H17O12P/c10-1-3-5(11)6(12)7(13)9(20-3)21-4(8(14)15)2-19-22(16,17)18/h3-7,9-13H,1-2H2,(H,14,15)(H2,16,17,18)/t3-,4?,5-,6+,7+,9-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:16351 xref: KEGG:C11516 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11536 name: (2R)-O-phospho-3-sulfolactic acid namespace: compound synonym: "(2R)-2-phospho-3-sulfolactate" EXACT [KEGG:KEGG] synonym: "C3H7O9PS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H7O9PS/c4-3(5)2(1-14(9,10)11)12-13(6,7)8/h2H,1H2,(H,4,5)(H2,6,7,8)(H,9,10,11)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:32896 xref: KEGG:C11536 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11537 name: (R)-3-sulfolactate namespace: compound synonym: "(2R)-3-sulfolactate" EXACT [KEGG:KEGG] synonym: "C3H6O6S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/t2-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:48291 xref: KEGG:C11537 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11538 name: cobalt-precorrin-2 namespace: compound synonym: "C42H44CoN4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "co-precorrin 2" EXACT [KEGG:KEGG] synonym: "cobalt-precorrin 2" EXACT [KEGG:KEGG] synonym: "InChI=1S/C42H46N4O16.Co/c1-41(17-39(59)60)23(5-9-35(51)52)29-14-27-21(11-37(55)56)19(3-7-33(47)48)25(43-27)13-26-20(4-8-34(49)50)22(12-38(57)58)28(44-26)15-31-42(2,18-40(61)62)24(6-10-36(53)54)30(46-31)16-32(41)45-29;/h13-16,23-24H,3-12,17-18H2,1-2H3,(H10,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62);/q;+2/p-2/t23-,24-,41+,42+;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:3790 xref: CHEBI:52491 xref: KEGG:C11538 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11539 name: cobalt-precorrin 3 namespace: compound synonym: "C43H48CoN4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "co-precorrin 3" EXACT [KEGG:KEGG] synonym: "InChI=1S/C43H49N4O16.Co/c1-19-40-23(13-37(58)59)21(5-9-33(50)51)27(46-40)14-26-20(4-8-32(48)49)22(12-36(56)57)28(44-26)15-29-24(6-10-34(52)53)42(2,17-38(60)61)31(45-29)16-30-25(7-11-35(54)55)43(3,18-39(62)63)41(19)47-30;/h15-16,22,24-25H,4-14,17-18H2,1-3H3,(H9,44,45,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63);/q-1;+2/p-1/b41-19-;/t22?,24-,25-,42+,43+;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:3791 xref: KEGG:C11539 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11540 name: cobalt-precorrin 4 namespace: compound synonym: "C44H50CoN4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "co-precorrin 4" EXACT [KEGG:KEGG] synonym: "InChI=1S/C44H51N4O16.Co/c1-20-44-40-25(14-37(59)60)41(2,12-11-35(55)56)30(47-40)16-27-21(5-8-32(49)50)22(13-36(57)58)26(45-27)15-28-23(6-9-33(51)52)42(3,18-38(61)62)31(46-28)17-29(48-44)24(7-10-34(53)54)43(44,4)19-39(63)64-20;/h15,17,20,23-24H,5-14,16,18-19H2,1-4H3,(H8,46,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62);/q-1;+2/p-1/b28-15-;/t20?,23-,24-,41-,42+,43+,44?;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:3792 xref: KEGG:C11540 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11541 name: cobalt-precorrin 5 namespace: compound synonym: "C45H53CoN4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "co-precorrin 5" EXACT [KEGG:KEGG] synonym: "InChI=1S/C45H54N4O16.Co/c1-21-45-40-26(15-37(60)61)41(2,13-12-35(56)57)30(47-40)16-27-22(6-9-32(50)51)25(14-36(58)59)44(5,48-27)18-29-23(7-10-33(52)53)42(3,19-38(62)63)31(46-29)17-28(49-45)24(8-11-34(54)55)43(45,4)20-39(64)65-21;/h16-17,21,24,26H,6-15,18-20H2,1-5H3,(H8,46,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63);/q;+2/p-1/b30-16-;/t21?,24-,26?,41-,42+,43+,44+,45?;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:3793 xref: KEGG:C11541 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11542 name: cobalt-precorrin-6A namespace: compound synonym: "C44H53CoN4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "co-precorrin 6A" EXACT [KEGG:KEGG] synonym: "cobalt-precorrin 6" EXACT [KEGG:KEGG] synonym: "InChI=1S/C44H54N4O16.Co/c1-40(13-12-34(55)56)25(15-36(59)60)39-44(5)42(3,20-38(63)64)23(8-11-33(53)54)27(48-44)17-30-41(2,19-37(61)62)22(7-10-32(51)52)28(45-30)18-43(4)24(14-35(57)58)21(6-9-31(49)50)26(47-43)16-29(40)46-39;/h17,23H,6-16,18-20H2,1-5H3,(H9,45,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64);/q;+2/p-1/t23-,40-,41+,42+,43+,44+;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:3794 xref: KEGG:C11542 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11543 name: cobalt-precorrin-6B namespace: compound synonym: "C44H55CoN4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "co-precorrin 6B" EXACT [KEGG:KEGG] synonym: "cobalt-dihydro-precorrin 6" EXACT [KEGG:KEGG] synonym: "InChI=1S/C44H56N4O16.Co/c1-40(13-12-34(55)56)25(15-36(59)60)39-44(5)42(3,20-38(63)64)23(8-11-33(53)54)27(48-44)17-30-41(2,19-37(61)62)22(7-10-32(51)52)28(45-30)18-43(4)24(14-35(57)58)21(6-9-31(49)50)26(47-43)16-29(40)46-39;/h17,23,25,39H,6-16,18-20H2,1-5H3,(H9,45,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64);/q;+2/p-1/t23-,25+,39-,40-,41+,42+,43+,44+;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:3789 xref: KEGG:C11543 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11544 name: 2-(alpha-D-mannosyl)-D-glycerate namespace: compound synonym: "2(alpha-D-mannosyl)-D-glycerate" EXACT [KEGG:KEGG] synonym: "C9H16O9" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H16O9/c10-1-3-5(12)6(13)7(14)9(17-3)18-4(2-11)8(15)16/h3-7,9-14H,1-2H2,(H,15,16)/t3-,4-,5-,6+,7+,9-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:15847 xref: KEGG:C11544 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11545 name: cobalt-precorrin 8 namespace: compound synonym: "C45H59CoN4O14" RELATED FORMULA [KEGG:COMPOUND] synonym: "co-precorrin 8" EXACT [KEGG:KEGG] synonym: "InChI=1S/C45H60N4O14.Co/c1-21-36-24(9-12-29(50)51)23(3)44(7,48-36)18-28-25(10-13-30(52)53)42(5,19-34(60)61)39(46-28)22(2)37-26(11-14-31(54)55)43(6,20-35(62)63)45(8,49-37)40-27(17-33(58)59)41(4,38(21)47-40)16-15-32(56)57;/h21,26-27,40H,9-20H2,1-8H3,(H8,46,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63);/q;+2/p-1/t21?,26-,27+,40-,41-,42+,43+,44+,45+;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:3795 xref: KEGG:C11545 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11588 name: cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol namespace: compound synonym: "C9H12O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "cis-3-(carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol" EXACT [KEGG:KEGG] synonym: "InChI=1S/C9H12O4/c10-7-3-1-2-6(9(7)13)4-5-8(11)12/h1-3,7,9-10,13H,4-5H2,(H,11,12)/t7-,9+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:10472 xref: KEGG:C11588 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11638 name: 3-amino-2-oxopropyl phosphate namespace: compound synonym: "C3H8NO5P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H8NO5P/c4-1-3(5)2-9-10(6,7)8/h1-2,4H2,(H2,6,7,8)" RELATED InChI [UPa:] xref: CHEBI:1449 xref: KEGG:C11638 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11643 name: 16-hydroxytabersonine namespace: compound synonym: "C21H24N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C21H24N2O3/c1-3-20-7-4-9-23-10-8-21(19(20)23)15-6-5-13(24)11-16(15)22-17(21)14(12-20)18(25)26-2/h4-7,11,19,22,24H,3,8-10,12H2,1-2H3/t19-,20-,21-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:17699 xref: KEGG:C11643 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11675 name: 16-methoxytabersonine namespace: compound synonym: "C22H26N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C22H26N2O3/c1-4-21-8-5-10-24-11-9-22(20(21)24)16-7-6-14(26-2)12-17(16)23-18(22)15(13-21)19(25)27-3/h5-8,12,20,23H,4,9-11,13H2,1-3H3/t20-,21-,22-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:769 xref: KEGG:C11675 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11700 name: 10-deacetylbaccatin III namespace: compound synonym: "C29H36O10" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C29H36O10/c1-14-17(31)12-29(36)24(38-25(35)16-9-7-6-8-10-16)22-27(5,23(34)21(33)20(14)26(29,3)4)18(32)11-19-28(22,13-37-19)39-15(2)30/h6-10,17-19,21-22,24,31-33,36H,11-13H2,1-5H3/t17-,18-,19+,21+,22-,24-,27+,28-,29+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:18193 xref: KEGG:C11700 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11811 name: (2E)-4-hydroxy-3-methylbutenyl diphosphate namespace: compound synonym: "1-hydroxy-2-methyl-2-butenyl 4-diphosphate" EXACT [KEGG:KEGG] synonym: "C5H12O8P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H12O8P2/c1-5(4-6)2-3-12-15(10,11)13-14(7,8)9/h2,6H,3-4H2,1H3,(H,10,11)(H2,7,8,9)/b5-2+" RELATED InChI [UPa:] xref: CHEBI:15664 xref: KEGG:C11811 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11821 name: 5-hydroxyisouric acid namespace: compound synonym: "C5H4N4O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H4N4O4/c10-2-5(13)1(6-3(11)8-2)7-4(12)9-5/h13H,(H3,6,7,8,9,10,11,12)" RELATED InChI [UPa:] xref: CHEBI:18072 xref: KEGG:C11821 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11894 name: taxa-4,11-diene namespace: compound synonym: "C20H32" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C20H32/c1-14-7-6-11-20(5)12-10-17-15(2)8-9-16(13-18(14)20)19(17,3)4/h7,16,18H,6,8-13H2,1-5H3/t16-,18+,20-/m0/s1" RELATED InChI [UPa:] synonym: "taxa-4(5),11(12)-diene" EXACT [KEGG:KEGG] xref: CHEBI:30037 xref: KEGG:C11894 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11895 name: taxa-4(20),11-dien-5alpha-ol namespace: compound synonym: "C20H32O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C20H32O/c1-13-6-7-15-12-17-14(2)18(21)9-11-20(17,5)10-8-16(13)19(15,3)4/h15,17-18,21H,2,6-12H2,1,3-5H3/t15-,17+,18-,20+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:30038 xref: KEGG:C11895 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11896 name: taxa-4(20),11-dien-5alpha-yl acetate namespace: compound synonym: "C22H34O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C22H34O2/c1-14-7-8-17-13-19-15(2)20(24-16(3)23)10-12-22(19,6)11-9-18(14)21(17,4)5/h17,19-20H,2,7-13H2,1,3-6H3/t17-,19+,20-,22+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:30042 xref: KEGG:C11896 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11898 name: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate namespace: compound synonym: "C22H34O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C22H34O3/c1-13-7-8-16-11-17-14(2)19(25-15(3)23)9-10-22(17,6)12-18(24)20(13)21(16,4)5/h16-19,24H,2,7-12H2,1,3-6H3/t16-,17+,18-,19-,22-/m0/s1" RELATED InChI [UPa:] synonym: "taxa-4(20),11(12)-dien-5alpha-acetoxy-10beta-ol" EXACT [KEGG:KEGG] xref: CHEBI:50436 xref: KEGG:C11898 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11899 name: 10-deacetyl-2-debenzoylbaccatin III namespace: compound synonym: "C22H32O9" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C22H32O9/c1-9-11(24)7-22(29)18(28)16-20(5,17(27)15(26)14(9)19(22,3)4)12(25)6-13-21(16,8-30-13)31-10(2)23/h11-13,15-16,18,24-26,28-29H,6-8H2,1-5H3/t11-,12-,13+,15+,16-,18-,20+,21-,22+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:32897 xref: KEGG:C11899 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11900 name: baccatin III namespace: compound synonym: "C31H38O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C31H38O11/c1-15-19(34)13-31(38)26(41-27(37)18-10-8-7-9-11-18)24-29(6,20(35)12-21-30(24,14-39-21)42-17(3)33)25(36)23(40-16(2)32)22(15)28(31,4)5/h7-11,19-21,23-24,26,34-35,38H,12-14H2,1-6H3/t19-,20-,21+,23+,24-,26-,29+,30-,31+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:32898 xref: KEGG:C11900 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11903 name: methanophenazine namespace: compound synonym: "C37H50N2O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C37H50N2O/c1-28(2)13-9-14-29(3)15-10-16-30(4)17-11-18-31(5)19-12-20-32(6)25-26-40-33-23-24-36-37(27-33)39-35-22-8-7-21-34(35)38-36/h7-8,13,15,17,19,21-24,27,32H,9-12,14,16,18,20,25-26H2,1-6H3/b29-15+,30-17+,31-19+" RELATED InChI [UPa:] xref: CHEBI:29118 xref: KEGG:C11903 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11904 name: dihydromethanophenazine namespace: compound synonym: "C37H52N2O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C37H52N2O/c1-28(2)13-9-14-29(3)15-10-16-30(4)17-11-18-31(5)19-12-20-32(6)25-26-40-33-23-24-36-37(27-33)39-35-22-8-7-21-34(35)38-36/h7-8,13,15,17,19,21-24,27,32,38-39H,9-12,14,16,18,20,25-26H2,1-6H3/b29-15+,30-17+,31-19+" RELATED InChI [UPa:] xref: CHEBI:50375 xref: KEGG:C11904 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC11937 name: (1S,4R)-1-hydroxylimonen-2-one namespace: compound synonym: "(1S,4R)-1-hydroxy-2-oxolimonene" EXACT [KEGG:KEGG] synonym: "C10H16O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H16O2/c1-7(2)8-4-5-10(3,12)9(11)6-8/h8,12H,1,4-6H2,2-3H3/t8-,10+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:38249 xref: KEGG:C11937 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC12041 name: tyrocidine namespace: compound synonym: "C66H87N13O13" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C66H87N13O13/c1-38(2)32-47-59(85)77-52(36-42-20-12-7-13-21-42)66(92)79-31-15-23-53(79)64(90)76-49(34-41-18-10-6-11-19-41)61(87)74-48(33-40-16-8-5-9-17-40)60(86)75-51(37-55(69)82)62(88)70-46(28-29-54(68)81)58(84)73-50(35-43-24-26-44(80)27-25-43)63(89)78-56(39(3)4)65(91)71-45(22-14-30-67)57(83)72-47/h5-13,16-21,24-27,38-39,45-53,56,80H,14-15,22-23,28-37,67H2,1-4H3,(H2,68,81)(H2,69,82)(H,70,88)(H,71,91)(H,72,83)(H,73,84)(H,74,87)(H,75,86)(H,76,90)(H,77,85)(H,78,89)/t45-,46-,47-,48+,49-,50-,51-,52+,53-,56-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:29701 xref: CHEBI:71947 xref: KEGG:C12041 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC12043 name: surfactin namespace: compound synonym: "C53H93N7O13" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C53H93N7O13/c1-30(2)20-18-16-14-13-15-17-19-21-36-28-43(61)54-37(22-23-44(62)63)47(66)55-38(24-31(3)4)48(67)57-40(26-33(7)8)51(70)60-46(35(11)12)52(71)58-41(29-45(64)65)50(69)56-39(25-32(5)6)49(68)59-42(27-34(9)10)53(72)73-36/h30-42,46H,13-29H2,1-12H3,(H,54,61)(H,55,66)(H,56,69)(H,57,67)(H,58,71)(H,59,68)(H,60,70)(H,62,63)(H,64,65)/t36-,37+,38+,39-,40-,41+,42+,46+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:29681 xref: CHEBI:71978 xref: KEGG:C12043 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC12212 name: kanosamine namespace: compound synonym: "C6H13NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13NO5/c7-3-4(9)2(1-8)12-6(11)5(3)10/h2-6,8-11H,1,7H2/t2-,3+,4-,5-,6?/m1/s1" RELATED InChI [UPa:] xref: CHEBI:72725 xref: KEGG:C12212 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC12216 name: mycobactin namespace: compound synonym: "C44H69N5O10" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C44H69N5O10/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28-40(52)48(56)29-22-21-26-36(46-41(53)37-32-58-42(47-37)34-24-18-19-27-38(34)50)44(55)59-33(2)31-39(51)45-35-25-20-23-30-49(57)43(35)54/h17-19,24,27-28,33,35-37,50,56-57H,3-16,20-23,25-26,29-32H2,1-2H3,(H,45,51)(H,46,53)/b28-17+" RELATED InChI [UPa:] xref: CHEBI:31870 xref: KEGG:C12216 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC12219 name: bacillibactin namespace: compound synonym: "C39H42N6O18" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C39H42N6O18/c1-16-28(43-25(49)13-40-34(55)19-7-4-10-22(46)31(19)52)37(58)62-18(3)30(45-27(51)15-42-36(57)21-9-6-12-24(48)33(21)54)39(60)63-17(2)29(38(59)61-16)44-26(50)14-41-35(56)20-8-5-11-23(47)32(20)53/h4-12,16-18,28-30,46-48,52-54H,13-15H2,1-3H3,(H,40,55)(H,41,56)(H,42,57)(H,43,49)(H,44,50)(H,45,51)/t16-,17-,18-,28+,29+,30+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:31432 xref: KEGG:C12219 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC12248 name: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid namespace: compound synonym: "C5H6N4O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H6N4O5/c6-3(12)7-1-5(14,2(10)11)9-4(13)8-1/h14H,(H,10,11)(H4,6,7,8,9,12,13)" RELATED InChI [UPa:] xref: CHEBI:31132 xref: KEGG:C12248 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC12312 name: indolin-2-one namespace: compound synonym: "C8H7NO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-4H,5H2,(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:31697 xref: KEGG:C12312 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC12986 name: N-acetyl-L-2-aminoadipate namespace: compound synonym: "C8H13NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H13NO5/c1-5(10)9-6(8(13)14)3-2-4-7(11)12/h6H,2-4H2,1H3,(H,9,10)(H,11,12)(H,13,14)/t6-/m0/s1" RELATED InChI [UPa:] synonym: "N-acetyl-L-2-aminoadipic acid" EXACT [KEGG:KEGG] synonym: "N-acetyl-L-aminoadipate" EXACT [KEGG:KEGG] xref: CHEBI:31885 xref: CHEBI:61509 xref: KEGG:C12986 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC12987 name: N-acetyl-L-2-aminoadipate 5-phosphate namespace: compound synonym: "C8H14NO8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H14NO8P/c1-5(10)9-6(8(12)13)3-2-4-7(11)17-18(14,15)16/h6H,2-4H2,1H3,(H,9,10)(H,12,13)(H2,14,15,16)/t6-/m0/s1" RELATED InChI [UPa:] synonym: "N-acetyl-L-aminoadipic 5-phosphate" EXACT [KEGG:KEGG] xref: CHEBI:31887 xref: KEGG:C12987 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC12988 name: N-acetyl-L-2-aminoadipate semialdehyde namespace: compound synonym: "C8H13NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H13NO4/c1-6(11)9-7(8(12)13)4-2-3-5-10/h5,7H,2-4H2,1H3,(H,9,11)(H,12,13)/t7-/m0/s1" RELATED InChI [UPa:] synonym: "N-acetyl-L-aminoadipate-semialdehyde" EXACT [KEGG:KEGG] xref: CHEBI:61515 xref: KEGG:C12988 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC12989 name: N-acetyl-L-lysine namespace: compound synonym: "C8H16N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H16N2O3/c1-6(11)10-7(8(12)13)4-2-3-5-9/h7H,2-5,9H2,1H3,(H,10,11)(H,12,13)/t7-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:35704 xref: KEGG:C12989 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC13482 name: phosphodimethylethanolamine namespace: compound synonym: "C4H12NO4P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)" RELATED InChI [UPa:] xref: CHEBI:31997 xref: KEGG:C13482 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC13856 name: 2-arachidonoylglycerol namespace: compound synonym: "C23H38O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-" RELATED InChI [UPa:] xref: CHEBI:52392 xref: KEGG:C13856 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC14180 name: S-(hydroxymethyl)glutathione namespace: compound synonym: "C11H19N3O7S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:48926 xref: KEGG:C14180 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC14456 name: 4-chloronitrobenzene namespace: compound synonym: "C6H4ClNO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H4ClNO2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H" RELATED InChI [UPa:] xref: CHEBI:34399 xref: KEGG:C14456 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC14463 name: (R)-3-hydroxy-3-methyl-2-oxopentanoate namespace: compound synonym: "C6H10O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O4/c1-3-6(2,10)4(7)5(8)9/h10H,3H2,1-2H3,(H,8,9)/t6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:34008 xref: CHEBI:49257 xref: KEGG:C14463 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC14610 name: (S)-5-oxo-2,5-dihydro-2-furylacetic acid namespace: compound synonym: "2,5-dihydro-5-oxofuran-2-acetate" EXACT [KEGG:KEGG] synonym: "C6H6O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H6O4/c7-5(8)3-4-1-2-6(9)10-4/h1-2,4H,3H2,(H,7,8)/t4-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:48068 xref: KEGG:C14610 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC14818 name: Fe2+ namespace: compound synonym: "Fe" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/Fe/q+2" RELATED InChI [UPa:] xref: CHEBI:29033 xref: KEGG:C14818 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC14899 name: 3-dehydro-L-gulonate 6-phosphate namespace: compound synonym: "C6H11O10P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H11O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-3,5,7-8,10H,1H2,(H,11,12)(H2,13,14,15)/t2-,3+,5-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:49039 xref: KEGG:C14899 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15503 name: N,N-dihydroxy-L-tyrosine namespace: compound synonym: "C9H11NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H11NO5/c11-7-3-1-6(2-4-7)5-8(9(12)13)10(14)15/h1-4,8,11,14-15H,5H2,(H,12,13)/t8-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:12532 xref: KEGG:C15503 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15522 name: 4a-hydroxytetrahydrobiopterin namespace: compound synonym: "C9H15N5O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17)/t3-,4+,5-,9-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:15374 xref: KEGG:C15522 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15547 name: 1,4-dihydroxy-2-naphthoyl-CoA namespace: compound synonym: "C32H42N7O19P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C32H42N7O19P3S/c1-32(2,26(44)29(45)35-8-7-21(41)34-9-10-62-31(46)18-11-19(40)16-5-3-4-6-17(16)23(18)42)13-55-61(52,53)58-60(50,51)54-12-20-25(57-59(47,48)49)24(43)30(56-20)39-15-38-22-27(33)36-14-37-28(22)39/h3-6,11,14-15,20,24-26,30,40,42-44H,7-10,12-13H2,1-2H3,(H,34,41)(H,35,45)(H,50,51)(H,52,53)(H2,33,36,37)(H2,47,48,49)/t20-,24-,25-,26+,30-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:52668 xref: KEGG:C15547 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15549 name: anthocyanin namespace: compound synonym: "C15H11O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H11O/c1-2-6-12(7-3-1)15-11-10-13-8-4-5-9-14(13)16-15/h1-11H/q+1" RELATED InChI [UPa:] xref: CHEBI:36121 xref: KEGG:C15549 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15556 name: 2-hydroxy-3-oxobutyl phosphate namespace: compound synonym: "3,4-dihydroxy-2-butanone 4-phosphate" EXACT [KEGG:KEGG] synonym: "C4H9O6P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H9O6P/c1-3(5)4(6)2-10-11(7,8)9/h4,6H,2H2,1H3,(H2,7,8,9)" RELATED InChI [UPa:] xref: CHEBI:50606 xref: KEGG:C15556 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15602 name: Quinone namespace: compound xref: CHEBI:16509 xref: KEGG:C15602 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15603 name: Hydroquinone namespace: compound xref: CHEBI:17594 xref: KEGG:C15603 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15606 name: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one namespace: compound synonym: "C6H10O3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O3S/c1-10-3-2-5(8)6(9)4-7/h4,7,9H,2-3H2,1H3/b6-4-" RELATED InChI [UPa:] xref: CHEBI:49252 xref: KEGG:C15606 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15607 name: 3-oxo-3-ureidopropanoic acid namespace: compound synonym: "C4H6N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C4H6N2O4/c5-4(10)6-2(7)1-3(8)9/h1H2,(H,8,9)(H3,5,6,7,10)" RELATED InChI [UPa:] xref: CHEBI:49049 xref: KEGG:C15607 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15650 name: 5-(methylthio)-2,3-dioxopentyl phosphate namespace: compound synonym: "2,3-diketo-5-methylthiopentyl-1-phosphate" EXACT [KEGG:KEGG] synonym: "C6H11O6PS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H11O6PS/c1-14-3-2-5(7)6(8)4-12-13(9,10)11/h2-4H2,1H3,(H2,9,10,11)" RELATED InChI [UPa:] xref: CHEBI:50604 xref: KEGG:C15650 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15651 name: 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate namespace: compound synonym: "2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate" EXACT [KEGG:KEGG] synonym: "C6H11O6PS" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H11O6PS/c1-14-3-2-5(7)6(8)4-12-13(9,10)11/h4,8H,2-3H2,1H3,(H2,9,10,11)/b6-4-" RELATED InChI [UPa:] xref: CHEBI:50605 xref: KEGG:C15651 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15667 name: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole namespace: compound synonym: "C9H14N3O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H14N3O9P/c13-6-4(2-20-22(17,18)19)21-8(7(6)14)12-3-10-1-5(12)11-9(15)16/h1,3-4,6-8,11,13-14H,2H2,(H,15,16)(H2,17,18,19)/t4-,6-,7-,8-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:48000 xref: KEGG:C15667 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15670 name: heme A namespace: compound synonym: "C49H56FeN4O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C49H58N4O6.Fe/c1-9-34-31(6)39-25-45-49(46(55)18-12-17-30(5)16-11-15-29(4)14-10-13-28(2)3)33(8)40(52-45)24-44-37(27-54)36(20-22-48(58)59)43(53-44)26-42-35(19-21-47(56)57)32(7)38(51-42)23-41(34)50-39;/h9,13,15,17,23-27,46,55H,1,10-12,14,16,18-22H2,2-8H3,(H4,50,51,52,53,54,56,57,58,59);/q;+2/p-2/b29-15+,30-17+,38-23-,39-25-,40-24-,41-23-,42-26-,43-26-,44-24-,45-25-;" RELATED InChI [UPa:] xref: CHEBI:36163 xref: KEGG:C15670 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15672 name: heme O namespace: compound synonym: "C49H58FeN4O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C49H60N4O5.Fe/c1-10-35-31(6)40-26-45-49(46(54)19-13-18-30(5)17-12-16-29(4)15-11-14-28(2)3)34(9)41(53-45)24-38-32(7)36(20-22-47(55)56)43(51-38)27-44-37(21-23-48(57)58)33(8)39(52-44)25-42(35)50-40;/h10,14,16,18,24-27,46,54H,1,11-13,15,17,19-23H2,2-9H3,(H4,50,51,52,53,55,56,57,58);/q;+2/p-2/b29-16+,30-18+,38-24-,39-25-,40-26-,41-24-,42-25-,43-27-,44-27-,45-26-;" RELATED InChI [UPa:] xref: CHEBI:24480 xref: KEGG:C15672 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15699 name: gamma-L-glutamylputrescine namespace: compound synonym: "C9H19N3O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H19N3O3/c10-5-1-2-6-12-8(13)4-3-7(11)9(14)15/h7H,1-6,10-11H2,(H,12,13)(H,14,15)/t7-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:48005 xref: KEGG:C15699 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15700 name: gamma-glutamyl-4-aminobutanal namespace: compound synonym: "C9H16N2O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "gamma-glutamyl-gamma-aminobutyraldehyde" EXACT [KEGG:KEGG] synonym: "InChI=1S/C9H16N2O4/c10-7(9(14)15)3-4-8(13)11-5-1-2-6-12/h6-7H,1-5,10H2,(H,11,13)(H,14,15)/t7-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:61521 xref: KEGG:C15700 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15767 name: 4-(L-gamma-glutamylamino)butanoic acid namespace: compound synonym: "4-(glutamylamino)butanoate" EXACT [KEGG:KEGG] synonym: "C9H16N2O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C9H16N2O5/c10-6(9(15)16)3-4-7(12)11-5-1-2-8(13)14/h6H,1-5,10H2,(H,11,12)(H,13,14)(H,15,16)/t6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:49260 xref: KEGG:C15767 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15769 name: 2-hydroxy-1,4-benzoxazin-3-one namespace: compound synonym: "C8H7NO3" RELATED FORMULA [KEGG:COMPOUND] synonym: "HBOA" EXACT [KEGG:KEGG] synonym: "InChI=1S/C8H7NO3/c10-7-8(11)12-6-4-2-1-3-5(6)9-7/h1-4,8,11H,(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:63559 xref: KEGG:C15769 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15770 name: 2,4-dihydroxy-1,4-benzoxazin-3-one namespace: compound synonym: "C8H7NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H7NO4/c10-7-8(11)13-6-4-2-1-3-5(6)9(7)12/h1-4,8,11-12H" RELATED InChI [UPa:] xref: CHEBI:63558 xref: KEGG:C15770 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15777 name: episterol namespace: compound synonym: "C28H46O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C28H46O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h10,18,20-22,24-26,29H,3,7-9,11-17H2,1-2,4-6H3/t20-,21+,22+,24-,25+,26?,27+,28-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:50586 xref: KEGG:C15777 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15778 name: 5,7,24(28)-ergostatrienol namespace: compound synonym: "C28H44O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C28H44O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h9-10,18,20,22,24-26,29H,3,7-8,11-17H2,1-2,4-6H3/t20-,22+,24-,25+,26?,27+,28-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:80095 xref: KEGG:C15778 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15808 name: 4alpha-methylzymosterol-4-carboxylic acid namespace: compound synonym: "C29H46O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24-,25+,27-,28-,29+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:50591 xref: KEGG:C15808 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15816 name: 3-dehydro-4-methylzymosterol namespace: compound synonym: "3-keto-4-methylzymosterol" EXACT [KEGG:KEGG] synonym: "C28H44O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23+,24?,27-,28+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:50593 xref: KEGG:C15816 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15900 name: spheroidene namespace: compound synonym: "C41H60O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C41H60O/c1-34(2)20-14-23-37(5)26-17-29-38(6)27-15-24-35(3)21-12-13-22-36(4)25-16-28-39(7)30-18-31-40(8)32-19-33-41(9,10)42-11/h12-13,15-16,18-22,24-28,30-32H,14,17,23,29,33H2,1-11H3/b13-12+,24-15+,25-16+,30-18+,32-19+,35-21+,36-22+,37-26+,38-27+,39-28+,40-31+" RELATED InChI [UPa:] xref: CHEBI:35330 xref: KEGG:C15900 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15925 name: GDP-L-gulose namespace: compound synonym: "C16H25N5O16P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/t4-,5+,7+,8+,9-,10+,11-,14?,15+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:80182 xref: KEGG:C15925 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15926 name: beta-L-galactose 1-phosphate namespace: compound synonym: "C6H13O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3+,4+,5-,6+/m0/s1" RELATED InChI [UPa:] synonym: "L-galactose 1-phosphate" EXACT [KEGG:KEGG] xref: CHEBI:53072 xref: KEGG:C15926 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15972 name: Enzyme N6-(lipoyl)lysine namespace: compound xref: CHEBI:80218 xref: KEGG:C15972 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15973 name: Enzyme N6-(dihydrolipoyl)lysine namespace: compound xref: CHEBI:80219 xref: KEGG:C15973 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15986 name: 2,6-dihydroxypseudooxynicotine namespace: compound synonym: "C10H14N2O3" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H14N2O3/c1-11-6-2-3-8(13)7-4-5-9(14)12-10(7)15/h4-5,11H,2-3,6H2,1H3,(H2,12,14,15)" RELATED InChI [UPa:] xref: CHEBI:28220 xref: KEGG:C15986 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15987 name: 4-(methylamino)butanoate namespace: compound synonym: "4-(methylamino)butyric acid" EXACT [KEGG:KEGG] synonym: "C5H11NO2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H11NO2/c1-6-4-2-3-5(7)8/h6H,2-4H2,1H3,(H,7,8)" RELATED InChI [UPa:] xref: CHEBI:37755 xref: KEGG:C15987 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC15996 name: 7-cyano-7-deazaguanine namespace: compound synonym: "7-cyano-7-carbaguanine" EXACT [KEGG:KEGG] synonym: "C7H5N5O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H5N5O/c8-1-3-2-10-5-4(3)6(13)12-7(9)11-5/h2H,(H4,9,10,11,12,13)" RELATED InChI [UPa:] synonym: "preQ0" EXACT [KEGG:KEGG] xref: CHEBI:45075 xref: KEGG:C15996 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16142 name: germacrene D namespace: compound synonym: "C15H24" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H24/c1-12(2)15-10-8-13(3)6-5-7-14(4)9-11-15/h7-8,10,12,15H,3,5-6,9,11H2,1-2,4H3/b10-8+,14-7+/t15-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:49044 xref: KEGG:C16142 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16143 name: germacradienol namespace: compound synonym: "C15H26O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H26O/c1-12-6-5-7-13(2)9-11-14(10-8-12)15(3,4)16/h6,9,11,13-14,16H,5,7-8,10H2,1-4H3/b11-9+,12-6-/t13-,14+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:80351 xref: KEGG:C16143 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16144 name: dehydrosqualene namespace: compound synonym: "C30H48" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C30H48/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h9-10,15-18,23-24H,11-14,19-22H2,1-8H3/b10-9-,27-17+,28-18+,29-23+,30-24+" RELATED InChI [UPa:] xref: CHEBI:62738 xref: KEGG:C16144 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16145 name: 4,4'-diaponeurosporene namespace: compound synonym: "C30H42" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C30H42/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h9-11,13-19,21-24H,12,20H2,1-8H3/b10-9+,19-11+,21-13+,22-14+,27-17+,28-18+,29-23+,30-24+" RELATED InChI [UPa:] xref: CHEBI:62743 xref: KEGG:C16145 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16146 name: 4,4'-diaponeurosporenic acid namespace: compound synonym: "C30H40O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C30H40O2/c1-24(2)14-10-17-27(5)20-11-18-25(3)15-8-9-16-26(4)19-12-21-28(6)22-13-23-29(7)30(31)32/h8-9,11-16,18-23H,10,17H2,1-7H3,(H,31,32)/b9-8+,18-11+,19-12+,22-13+,25-15+,26-16+,27-20+,28-21+,29-23+" RELATED InChI [UPa:] xref: CHEBI:80352 xref: CHEBI:83048 xref: KEGG:C16146 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16147 name: glycosyl-4,4'-diaponeurosporenic acid namespace: compound synonym: "C36H50O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "glycosyl-4,4'-diaponeurosporenoate" EXACT [KEGG:KEGG] synonym: "InChI=1S/C36H50O7/c1-25(2)14-10-17-28(5)20-11-18-26(3)15-8-9-16-27(4)19-12-21-29(6)22-13-23-30(7)35(41)43-36-34(40)33(39)32(38)31(24-37)42-36/h8-9,11-16,18-23,31-34,36-40H,10,17,24H2,1-7H3/b9-8+,18-11+,19-12+,22-13+,26-15+,27-16+,28-20+,29-21+,30-23+/t31-,32-,33+,34-,36+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:80353 xref: KEGG:C16147 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16148 name: staphyloxanthin namespace: compound synonym: "C51H78O8" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C51H78O8/c1-10-39(4)26-17-15-13-11-12-14-16-18-36-46(52)57-37-45-47(53)48(54)49(55)51(58-45)59-50(56)44(9)35-24-34-43(8)33-23-31-41(6)28-20-19-27-40(5)30-22-32-42(7)29-21-25-38(2)3/h19-20,22-25,27-28,30-35,39,45,47-49,51,53-55H,10-18,21,26,29,36-37H2,1-9H3/b20-19+,30-22+,31-23+,34-24+,40-27+,41-28+,42-32+,43-33+,44-35+/t39?,45-,47-,48+,49-,51+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:71690 xref: KEGG:C16148 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16150 name: nicotine namespace: compound synonym: "C10H14N2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3" RELATED InChI [UPa:] xref: CHEBI:18723 xref: KEGG:C16150 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16153 name: UDP-4-amino-4-deoxy-L-arabinose namespace: compound synonym: "C14H23N3O15P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H23N3O15P2/c15-5-3-28-13(11(22)8(5)19)31-34(26,27)32-33(24,25)29-4-6-9(20)10(21)12(30-6)17-2-1-7(18)16-14(17)23/h1-2,5-6,8-13,19-22H,3-4,15H2,(H,24,25)(H,26,27)(H,16,18,23)/t5-,6+,8-,9+,10+,11+,12+,13+/m0/s1" RELATED InChI [UPa:] synonym: "UDP-L-Ara4N" EXACT [KEGG:KEGG] xref: CHEBI:47025 xref: KEGG:C16153 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16154 name: UDP-4-deoxy-4-formamido-beta-L-arabinose namespace: compound synonym: "C15H23N3O16P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H23N3O16P2/c19-5-16-6-3-30-14(12(24)9(6)21)33-36(28,29)34-35(26,27)31-4-7-10(22)11(23)13(32-7)18-2-1-8(20)17-15(18)25/h1-2,5-7,9-14,21-24H,3-4H2,(H,16,19)(H,26,27)(H,28,29)(H,17,20,25)/t6-,7+,9-,10+,11+,12+,13+,14+/m0/s1" RELATED InChI [UPa:] synonym: "UDP-beta-(4-deoxy-4-formamido-L-arabinose)" EXACT [KEGG:KEGG] xref: CHEBI:47027 xref: KEGG:C16154 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16155 name: UDP-beta-L-threo-pentopyranos-4-ulose namespace: compound synonym: "C14H20N2O16P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H20N2O16P2/c17-5-3-28-13(11(22)8(5)19)31-34(26,27)32-33(24,25)29-4-6-9(20)10(21)12(30-6)16-2-1-7(18)15-14(16)23/h1-2,6,8-13,19-22H,3-4H2,(H,24,25)(H,26,27)(H,15,18,23)/t6-,8+,9-,10-,11-,12-,13-/m1/s1" RELATED InChI [UPa:] synonym: "UDP-beta-(L-threo-pentapyranosyl-4''-ulose)" EXACT [KEGG:KEGG] xref: CHEBI:47028 xref: KEGG:C16155 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16156 name: 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate namespace: compound synonym: "4-deoxy-4-formamido-alpha-L-arabinose undecaprenyl phosphate" EXACT [KEGG:KEGG] synonym: "C61H100NO8P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C61H100NO8P/c1-47(2)23-13-24-48(3)25-14-26-49(4)27-15-28-50(5)29-16-30-51(6)31-17-32-52(7)33-18-34-53(8)35-19-36-54(9)37-20-38-55(10)39-21-40-56(11)41-22-42-57(12)43-44-69-71(66,67)70-61-60(65)59(64)58(45-68-61)62-46-63/h23,25,27,29,31,33,35,37,39,41,43,46,58-61,64-65H,13-22,24,26,28,30,32,34,36,38,40,42,44-45H2,1-12H3,(H,62,63)(H,66,67)/b48-25+,49-27+,50-29-,51-31-,52-33-,53-35-,54-37-,55-39-,56-41-,57-43-/t58-,59-,60+,61-/m0/s1" RELATED InChI [UPa:] synonym: "L-Ara4FN-phosphoundecaprenol" EXACT [KEGG:KEGG] xref: CHEBI:53028 xref: KEGG:C16156 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16157 name: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate namespace: compound synonym: "C60H100NO7P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C60H100NO7P/c1-46(2)23-13-24-47(3)25-14-26-48(4)27-15-28-49(5)29-16-30-50(6)31-17-32-51(7)33-18-34-52(8)35-19-36-53(9)37-20-38-54(10)39-21-40-55(11)41-22-42-56(12)43-44-67-69(64,65)68-60-59(63)58(62)57(61)45-66-60/h23,25,27,29,31,33,35,37,39,41,43,57-60,62-63H,13-22,24,26,28,30,32,34,36,38,40,42,44-45,61H2,1-12H3,(H,64,65)/b47-25+,48-27+,49-29-,50-31-,51-33-,52-35-,53-37-,54-39-,55-41-,56-43-/t57-,58-,59+,60-/m0/s1" RELATED InChI [UPa:] synonym: "L-Ara4N-phosphoundecaprenol" EXACT [KEGG:KEGG] xref: CHEBI:47039 xref: KEGG:C16157 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16159 name: 2-formylglutarate namespace: compound synonym: "C6H8O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H8O5/c7-3-4(6(10)11)1-2-5(8)9/h3-4H,1-2H2,(H,8,9)(H,10,11)" RELATED InChI [UPa:] xref: CHEBI:49075 xref: KEGG:C16159 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16186 name: L-ascorbate 6-phosphate namespace: compound synonym: "C6H9O9P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H9O9P/c7-2(1-14-16(11,12)13)5-3(8)4(9)6(10)15-5/h2,5,7-9H,1H2,(H2,11,12,13)/t2?,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:80368 xref: KEGG:C16186 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16236 name: protein N(6)-(octanoyl)lysine namespace: compound xref: CHEBI:80398 xref: KEGG:C16236 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16237 name: protein N(6)-(lipoyl)lysine namespace: compound xref: CHEBI:80399 xref: KEGG:C16237 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16238 name: lipoyl-AMP namespace: compound synonym: "C18H26N5O8PS2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C18H26N5O8PS2/c19-16-13-17(21-8-20-16)23(9-22-13)18-15(26)14(25)11(30-18)7-29-32(27,28)31-12(24)4-2-1-3-10-5-6-33-34-10/h8-11,14-15,18,25-26H,1-7H2,(H,27,28)(H2,19,20,21)/t10?,11-,14-,15-,18-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:55451 xref: KEGG:C16238 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16240 name: apoprotein namespace: compound xref: CHEBI:13850 xref: KEGG:C16240 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16242 name: cobalt-precorrin 5A namespace: compound synonym: "C45H52CoN4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C45H54N4O16.Co/c1-21-45-40-26(15-37(60)61)41(2,13-12-35(56)57)30(47-40)16-27-22(6-9-32(50)51)25(14-36(58)59)44(5,48-27)18-29-23(7-10-33(52)53)42(3,19-38(62)63)31(46-29)17-28(49-45)24(8-11-34(54)55)43(45,4)20-39(64)65-21;/h16-17,21,24H,6-15,18-20H2,1-5H3,(H9,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63);/q;+2/p-2/t21?,24-,41-,42+,43+,44+,45?;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:52488 xref: KEGG:C16242 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16243 name: cobalt-precorrin 5B namespace: compound synonym: "C43H50CoN4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C43H52N4O16.Co/c1-40(12-11-33(54)55)24(14-35(58)59)38-39-42(3,19-37(62)63)21(6-9-31(50)51)26(45-39)16-29-41(2,18-36(60)61)22(7-10-32(52)53)27(44-29)17-43(4)23(13-34(56)57)20(5-8-30(48)49)25(47-43)15-28(40)46-38;/h15-16,21,24H,5-14,17-19H2,1-4H3,(H10,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63);/q;+2/p-2/b39-38-;/t21-,24+,40-,41+,42+,43+;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:52489 xref: KEGG:C16243 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16269 name: epi-isozizaene namespace: compound synonym: "C15H24" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H24/c1-10-5-6-13-11(2)14(3,4)12-7-8-15(10,13)9-12/h10,12H,5-9H2,1-4H3/t10-,12-,15+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:51458 xref: KEGG:C16269 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16286 name: geosmin namespace: compound synonym: "C12H22O" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H22O/c1-10-6-5-8-11(2)7-3-4-9-12(10,11)13/h10,13H,3-9H2,1-2H3/t10-,11+,12-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:46702 xref: KEGG:C16286 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16348 name: cis-3-chloroallyl aldehyde namespace: compound synonym: "C3H3ClO" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C3H3ClO/c4-2-1-3-5/h1-3H/b2-1-" RELATED InChI [UPa:] xref: CHEBI:80465 xref: KEGG:C16348 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16386 name: (R)-nicotine namespace: compound synonym: "C10H14N2" RELATED FORMULA [KEGG:COMPOUND] synonym: "D-nicotine" EXACT [KEGG:KEGG] synonym: "InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:39162 xref: KEGG:C16386 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16390 name: 2-hydroxymethylglutarate namespace: compound synonym: "C6H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O5/c7-3-4(6(10)11)1-2-5(8)9/h4,7H,1-3H2,(H,8,9)(H,10,11)" RELATED InChI [UPa:] xref: CHEBI:49076 xref: CHEBI:49077 xref: KEGG:C16390 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16440 name: lysine namespace: compound synonym: "C6H14N2O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)" RELATED InChI [UPa:] xref: CHEBI:25094 xref: KEGG:C16440 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16463 name: 3',5'-cyclic di-GMP namespace: compound synonym: "C20H24N10O14P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C20H24N10O14P2/c21-19-25-13-7(15(33)27-19)23-3-29(13)17-9(31)11-5(41-17)1-39-45(35,36)44-12-6(2-40-46(37,38)43-11)42-18(10(12)32)30-4-24-8-14(30)26-20(22)28-16(8)34/h3-6,9-12,17-18,31-32H,1-2H2,(H,35,36)(H,37,38)(H3,21,25,27,33)(H3,22,26,28,34)/t5-,6-,9-,10-,11-,12-,17-,18-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:49537 xref: KEGG:C16463 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16488 name: fructoselysine namespace: compound synonym: "C12H24N2O7" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H24N2O7/c13-7(12(20)21)3-1-2-4-14-5-8(16)10(18)11(19)9(17)6-15/h7,9-11,14-15,17-19H,1-6,13H2,(H,20,21)/t7-,9+,10+,11+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:24109 xref: KEGG:C16488 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16489 name: fructoselysine 6-phosphate namespace: compound synonym: "C12H25N2O10P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H25N2O10P/c13-7(12(19)20)3-1-2-4-14-5-8(15)10(17)11(18)9(16)6-24-25(21,22)23/h7,9-11,14,16-18H,1-6,13H2,(H,19,20)(H2,21,22,23)/t7-,9+,10+,11+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:61437 xref: KEGG:C16489 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16519 name: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid namespace: compound synonym: "2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate" EXACT [KEGG:KEGG] synonym: "C14H16O9" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C14H16O9/c1-6(13(19)20)23-9-4-2-7(8(15)3-5-10(16)17)11(12(9)18)14(21)22/h2,4,7,9,11-12,18H,1,3,5H2,(H,16,17)(H,19,20)(H,21,22)/t7-,9+,11-,12-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:50271 xref: KEGG:C16519 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16523 name: N-(3'R)-debenzoyl-2'-deoxytaxol namespace: compound synonym: "C40H47NO12" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H47NO12/c1-21-27(51-30(45)17-26(41)24-13-9-7-10-14-24)19-40(48)35(52-36(47)25-15-11-8-12-16-25)33-38(6,28(44)18-29-39(33,20-49-29)53-23(3)43)34(46)32(50-22(2)42)31(21)37(40,4)5/h7-16,26-29,32-33,35,44,48H,17-20,41H2,1-6H3/t26-,27+,28+,29-,32-,33?,35+,38-,39+,40-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:74030 xref: KEGG:C16523 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16524 name: N-(3'R)-debenzoyltaxol namespace: compound synonym: "C40H47NO13" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C40H47NO13/c1-20-25(52-36(48)30(45)29(41)23-13-9-7-10-14-23)18-40(49)34(53-35(47)24-15-11-8-12-16-24)32-38(6,26(44)17-27-39(32,19-50-27)54-22(3)43)33(46)31(51-21(2)42)28(20)37(40,4)5/h7-16,25-27,29-32,34,44-45,49H,17-19,41H2,1-6H3/t25-,26-,27+,29-,30+,31+,32?,34-,38+,39-,40+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:63862 xref: KEGG:C16524 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16589 name: 2-oxosuberate namespace: compound synonym: "C8H12O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C8H12O5/c9-6(8(12)13)4-2-1-3-5-7(10)11/h1-5H2,(H,10,11)(H,12,13)" RELATED InChI [UPa:] xref: CHEBI:80587 xref: KEGG:C16589 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16636 name: tRNA(Sec) namespace: compound xref: KEGG:C16636 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16638 name: O-phosphoseryl-tRNA(Sec) namespace: compound xref: CHEBI:80628 xref: KEGG:C16638 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16639 name: beta-D-ribofuranose namespace: compound synonym: "C5H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C5H10O5/c6-1-2-3(7)4(8)5(9)10-2/h2-9H,1H2/t2-,3-,4-,5-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:47002 xref: KEGG:C16639 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16665 name: 12-methyltetradecanoic acid namespace: compound synonym: "C15H30O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C15H30O2/c1-3-14(2)12-10-8-6-4-5-7-9-11-13-15(16)17/h14H,3-13H2,1-2H3,(H,16,17)" RELATED InChI [UPa:] xref: CHEBI:39251 xref: KEGG:C16665 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16737 name: 5-deoxy-D-glucuronic acid namespace: compound synonym: "5-deoxy glucuronic acid" EXACT [KEGG:KEGG] synonym: "C6H10O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O6/c7-2-4(9)6(12)3(8)1-5(10)11/h2-4,6,8-9,12H,1H2,(H,10,11)/t3-,4+,6+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:50923 xref: KEGG:C16737 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC16833 name: beta-phenylalanoyl-CoA namespace: compound synonym: "C30H45N8O17P3S" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C30H45N8O17P3S/c1-30(2,25(42)28(43)34-9-8-20(39)33-10-11-59-21(40)12-18(31)17-6-4-3-5-7-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)38-16-37-22-26(32)35-15-36-27(22)38/h3-7,15-16,18-19,23-25,29,41-42H,8-14,31H2,1-2H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/t18-,19-,23-,24-,25+,29-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:80761 xref: CHEBI:83170 xref: KEGG:C16833 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC17023 name: sulfur donor namespace: compound xref: CHEBI:80867 xref: KEGG:C17023 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC17209 name: 2-deoxy-scyllo-inosose namespace: compound synonym: "2,3,4,5-tetrahydroxycyclohexanone" EXACT [KEGG:KEGG] synonym: "C6H10O5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H10O5/c7-2-1-3(8)5(10)6(11)4(2)9/h2,4-7,9-11H,1H2/t2-,4+,5-,6-/m1/s1" RELATED InChI [UPa:] xref: CHEBI:64796 xref: KEGG:C17209 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC17401 name: cobalt-factor III namespace: compound synonym: "C43H46CoN4O16" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C43H48N4O16.Co/c1-19-40-23(13-37(58)59)21(5-9-33(50)51)27(46-40)14-26-20(4-8-32(48)49)22(12-36(56)57)28(44-26)15-29-24(6-10-34(52)53)42(2,17-38(60)61)31(45-29)16-30-25(7-11-35(54)55)43(3,18-39(62)63)41(19)47-30;/h14-16,24-25H,4-13,17-18H2,1-3H3,(H10,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63);/q;+2/p-2/t24-,25-,42+,43+;/m1./s1" RELATED InChI [UPa:] xref: CHEBI:73373 xref: KEGG:C17401 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC17556 name: di-trans,poly-cis-undecaprenyl phosphate namespace: compound synonym: "C55H91O4P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C55H91O4P/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)41-22-42-55(12)43-44-59-60(56,57)58/h23,25,27,29,31,33,35,37,39,41,43H,13-22,24,26,28,30,32,34,36,38,40,42,44H2,1-12H3,(H2,56,57,58)/b46-25+,47-27+,48-29-,49-31-,50-33-,51-35-,52-37-,53-39-,54-41-,55-43-" RELATED InChI [UPa:] xref: CHEBI:60468 xref: KEGG:C17556 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC17580 name: 2-deoxy-scyllo-inosamine namespace: compound synonym: "C6H13NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H13NO4/c7-2-1-3(8)5(10)6(11)4(2)9/h2-6,8-11H,1,7H2/t2-,3+,4+,5-,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:65046 xref: KEGG:C17580 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC17581 name: 3-amino-2,3-dideoxy-scyllo-inosose namespace: compound synonym: "C6H11NO4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C6H11NO4/c7-2-1-3(8)5(10)6(11)4(2)9/h2,4-6,9-11H,1,7H2/t2-,4+,5-,6-/m0/s1" RELATED InChI [UPa:] xref: CHEBI:65027 xref: KEGG:C17581 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC17708 name: fortimicin namespace: compound synonym: "C17H35N5O6" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C17H35N5O6/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+/m0/s1" RELATED InChI [UPa:] xref: CHEBI:37923 xref: KEGG:C17708 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC18050 name: beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate namespace: compound synonym: "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate" EXACT [KEGG:KEGG] synonym: "C12H23O14P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H23O14P/c13-1-4-6(15)8(17)9(18)11(24-4)26-12(3-14)10(19)7(16)5(25-12)2-23-27(20,21)22/h4-11,13-19H,1-3H2,(H2,20,21,22)/t4-,5-,6-,7-,8+,9+,10+,11-,12+/m1/s1" RELATED InChI [UPa:] synonym: "mannosylfructose-phosphate" EXACT [KEGG:KEGG] xref: CHEBI:51834 xref: KEGG:C18050 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC18068 name: beta-D-fructofuranosyl alpha-D-mannopyranoside namespace: compound synonym: "beta-D-fructofuranosyl alpha-D-mannopyranoside" EXACT [KEGG:KEGG] synonym: "C12H22O11" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9+,10+,11-,12+/m1/s1" RELATED InChI [UPa:] xref: CHEBI:51833 xref: KEGG:C18068 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19671 name: amicyanin namespace: compound xref: KEGG:C19671 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19672 name: reduced amicyanin namespace: compound xref: KEGG:C19672 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19847 name: demethylmenaquinol namespace: compound synonym: "C20H24O2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C20H24O2/c1-14(2)7-6-8-15(3)11-12-16-13-19(21)17-9-4-5-10-18(17)20(16)22/h4-5,7,9-11,13,21-22H,6,8,12H2,1-3H3/b15-11+" RELATED InChI [UPa:] xref: CHEBI:55437 xref: KEGG:C19847 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19878 name: D-glycero-alpha-D-manno-heptose 7-phosphate namespace: compound synonym: "C7H15O10P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H15O10P/c8-2(1-16-18(13,14)15)6-4(10)3(9)5(11)7(12)17-6/h2-12H,1H2,(H2,13,14,15)/t2-,3+,4+,5+,6-,7+/m1/s1" RELATED InChI [UPa:] xref: KEGG:C19878 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19879 name: D-glycero-alpha-D-manno-heptose 1,7-diphosphate namespace: compound synonym: "C7H16O13P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H16O13P2/c8-2(1-18-21(12,13)14)6-4(10)3(9)5(11)7(19-6)20-22(15,16)17/h2-11H,1H2,(H2,12,13,14)(H2,15,16,17)/t2-,3+,4+,5+,6-,7-/m1/s1" RELATED InChI [UPa:] xref: KEGG:C19879 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19880 name: D-glycero-alpha-D-manno-heptose 1-phosphate namespace: compound synonym: "C7H15O10P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H15O10P/c8-1-2(9)6-4(11)3(10)5(12)7(16-6)17-18(13,14)15/h2-12H,1H2,(H2,13,14,15)/t2-,3+,4+,5+,6-,7-/m1/s1" RELATED InChI [UPa:] xref: KEGG:C19880 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19881 name: GDP-D-glycero-alpha-D-manno-heptose namespace: compound synonym: "C17H27N5O17P2" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C17H27N5O17P2/c18-17-20-13-6(14(30)21-17)19-3-22(13)15-10(28)7(25)5(36-15)2-35-40(31,32)39-41(33,34)38-16-11(29)8(26)9(27)12(37-16)4(24)1-23/h3-5,7-12,15-16,23-29H,1-2H2,(H,31,32)(H,33,34)(H3,18,20,21,30)/t4-,5-,7-,8+,9+,10-,11+,12-,15-,16-/m1/s1" RELATED InChI [UPa:] xref: KEGG:C19881 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19882 name: D-glycero-D-manno-heptose 7-phosphate namespace: compound synonym: "C7H15O10P" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H15O10P/c8-2(1-16-18(13,14)15)6-4(10)3(9)5(11)7(12)17-6/h2-12H,1H2,(H2,13,14,15)/t2-,3+,4+,5+,6-,7?/m1/s1" RELATED InChI [UPa:] xref: KEGG:C19882 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19885 name: [LysW] namespace: compound xref: KEGG:C19885 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19886 name: [LysW]-L-2-aminoadipate namespace: compound xref: KEGG:C19886 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19887 name: [LysW]-L-2-aminoadipyl 6-phosphate namespace: compound xref: KEGG:C19887 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19888 name: [LysW]-L-2-aminoadipate 6-semialdehyde namespace: compound xref: KEGG:C19888 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC19889 name: [LysW]-L-lysine namespace: compound xref: KEGG:C19889 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC20151 name: 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate namespace: compound synonym: "C22H34O4" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C22H34O4/c1-12-9-17(24)16-10-15-13(2)19(26-14(3)23)7-8-22(15,6)11-18(25)20(12)21(16,4)5/h15-19,24-25H,2,7-11H2,1,3-6H3/t15-,16-,17+,18+,19+,22+/m1/s1" RELATED InChI [UPa:] xref: KEGG:C20151 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPC20258 name: (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate namespace: compound synonym: "C7H9NO5" RELATED FORMULA [KEGG:COMPOUND] synonym: "InChI=1S/C7H9NO5/c9-3-1-4(6(10)11)8-5(2-3)7(12)13/h3-4,9H,1-2H2,(H,10,11)(H,12,13)/t3-,4-/m0/s1" RELATED InChI [UPa:] xref: KEGG:C20258 is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00024 name: pectate(n-2) namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00029 name: trisporate namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00030 name: fructose namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00031 name: methylnaphthalene namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00033 name: polyhydroxyalkanoate namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00034 name: terpenoid namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00035 name: nucleotide-sugar namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00036 name: amino-sugar namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00037 name: bile acid namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00038 name: sphingolipid namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00039 name: xylene namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00040 name: C21-steroid hormone namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00041 name: glycerolipid namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00042 name: 1,6-anhydro-N-acetylmuramate namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00043 name: aldonic acid namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00044 name: aldaric acid namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00045 name: tartrate namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00046 name: mycolic acid namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00047 name: poly-(R)-3-hydroxybutanoate namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00048 name: colanic acid namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00049 name: lactose namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00050 name: 2-deoxy-D-ribose 1-phosphate namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00051 name: 4-amino-4-deoxy-beta-L-arabinose namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00052 name: 4-amino-4-deoxy-beta-L-arabinose-lipid A namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00053 name: lipid A namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00054 name: tetrahydrofolate namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00055 name: ectoine namespace: compound is_a: UPa:UPC00000 ! compound [Term] id: UPa:UPX00056 name: trehalose namespace: compound is_a: UPa:UPC00000 ! compound [Typedef] id: BFO:0000051 name: has part def: "a core relation that holds between a whole and its part" [] property_value: IAO:0000111 "has part" xsd:string property_value: IAO:0000112 "my body has part my brain (continuant parthood, two material entities)" xsd:string property_value: IAO:0000112 "my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)" xsd:string property_value: IAO:0000112 "this year has part this day (occurrent parthood)" xsd:string property_value: IAO:0000116 "Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part." xsd:string property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string property_value: IAO:0000116 "Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)\n\nA continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'." xsd:string property_value: IAO:0000118 "has_part" xsd:string property_value: RO:0001900 RO:0001901 is_transitive: true is_a: RO:0002131 ! overlaps [Typedef] id: BFO:0000063 name: precedes def: "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco property_value: IAO:0000111 "precedes" xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent holds_over_chain: part_of BFO:0000063 is_transitive: true is_a: RO:0002222 ! temporally related to [Typedef] id: BFO:0000066 name: occurs in def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" [] comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant property_value: IAO:0000111 "occurs in" xsd:string property_value: IAO:0000118 "occurs_in" xsd:string property_value: IAO:0000118 "unfolds in" xsd:string property_value: IAO:0000118 "unfolds_in" xsd:string property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl domain: BFO:0000003 ! occurrent range: BFO:0000004 ! independent continuant holds_over_chain: part_of BFO:0000066 inverse_of: BFO:0000067 ! contains process transitive_over: part_of ! part of [Typedef] id: BFO:0000067 name: contains process def: "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" [] comment: Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant property_value: IAO:0000111 "site of" xsd:string property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Typedef] id: RO:0000056 name: participates in def: "a relation between a continuant and a process, in which the continuant is somehow involved in the process" [] property_value: IAO:0000111 "participates in" xsd:string property_value: IAO:0000112 "this blood clot participates in this blood coagulation" xsd:string property_value: IAO:0000112 "this input material (or this output material) participates in this process" xsd:string property_value: IAO:0000112 "this investigator participates in this investigation" xsd:string property_value: IAO:0000118 "participates_in" xsd:string domain: BFO:0000002 ! continuant range: BFO:0000003 ! occurrent inverse_of: RO:0000057 ! has participant [Typedef] id: RO:0000057 name: has participant def: "a relation between a process and a continuant, in which the continuant is somehow involved in the process" [] property_value: http://purl.org/dc/elements/1.1/source "http://www.obofoundry.org/ro/#OBO_REL:has_participant" xsd:string property_value: IAO:0000111 "has participant" xsd:string property_value: IAO:0000112 "this blood coagulation has participant this blood clot" xsd:string property_value: IAO:0000112 "this investigation has participant this investigator" xsd:string property_value: IAO:0000112 "this process has participant this input material (or this output material)" xsd:string property_value: IAO:0000116 "Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time." xsd:string property_value: IAO:0000118 "has_participant" xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000002 ! continuant holds_over_chain: BFO:0000051 RO:0000057 [Typedef] id: RO:0002013 name: has regulatory component activity def: "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." [] is_a: RO:0002017 ! has component activity is_a: RO:0002334 ! regulated by created_by: dos creation_date: 2017-05-24T09:30:46Z [Typedef] id: RO:0002014 name: has negative regulatory component activity def: "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." [] comment: By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'. is_a: RO:0002013 ! has regulatory component activity is_a: RO:0002335 ! negatively regulated by created_by: dos creation_date: 2017-05-24T09:31:01Z [Typedef] id: RO:0002015 name: has positive regulatory component activity def: "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." [] comment: By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'. is_a: RO:0002013 ! has regulatory component activity is_a: RO:0002336 ! positively regulated by created_by: dos creation_date: 2017-05-24T09:31:17Z [Typedef] id: RO:0002017 name: has component activity comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B. is_a: RO:0002018 ! has component process created_by: dos creation_date: 2017-05-24T09:44:33Z [Typedef] id: RO:0002018 name: has component process def: "w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." [] is_a: RO:0002180 ! has component created_by: dos creation_date: 2017-05-24T09:49:21Z [Typedef] id: RO:0002019 name: has ligand def: "A relationship that holds between between a receptor and an chemical entity, typically a small molecule or peptide, that carries information between cells or compartments of a cell and which binds the receptor and regulates its effector function." [] domain: GO:0004872 is_a: has_input_compound ! has input created_by: dos creation_date: 2017-07-19T17:30:36Z [Typedef] id: RO:0002022 name: directly regulated by comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. {xref="GOC:dos"} is_a: RO:0002334 ! regulated by inverse_of: RO:0002578 ! directly regulates created_by: dos creation_date: 2017-09-17T13:52:24Z [Typedef] id: RO:0002023 name: directly negatively regulated by def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." [GOC:dos] is_a: RO:0002022 ! directly regulated by inverse_of: RO:0002630 ! directly negatively regulates created_by: dos creation_date: 2017-09-17T13:52:38Z [Typedef] id: RO:0002024 name: directly positively regulated by def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." [GOC:dos] is_a: RO:0002022 ! directly regulated by inverse_of: RO:0002629 ! directly positively regulates created_by: dos creation_date: 2017-09-17T13:52:47Z [Typedef] id: RO:0002025 name: has effector activity def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." [GOC:dos] comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations. is_functional: true is_a: RO:0002017 ! has component activity is_a: RO:0002211 ! regulates created_by: dos creation_date: 2017-09-22T14:14:36Z [Typedef] id: RO:0002086 name: ends after comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) subset: ro-eco property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string is_transitive: true is_a: RO:0002222 ! temporally related to [Typedef] id: RO:0002087 name: immediately preceded by comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000118 "starts_at_end_of" xsd:string is_a: preceded_by ! preceded by inverse_of: RO:0002090 ! immediately precedes [Typedef] id: RO:0002090 name: immediately precedes comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) subset: ro-eco property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000118 "ends_at_start_of" xsd:string property_value: IAO:0000118 "meets" xsd:string property_value: RO:0002575 BFO:0000063 is_a: BFO:0000063 ! precedes [Typedef] id: RO:0002131 name: overlaps def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" [] subset: ro-eco property_value: IAO:0000114 IAO:0000125 property_value: RO:0001900 RO:0001901 holds_over_chain: BFO:0000051 part_of {RO:0002582="true"} holds_over_chain: BFO:0000051 RO:0002131 holds_over_chain: part_of part_of is_a: RO:0002323 ! mereotopologically related to expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)" [] [Typedef] id: RO:0002180 name: has component def: "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." [] subset: ro-eco property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000116 "The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity." xsd:string property_value: IAO:0000232 "For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit." xsd:string property_value: RO:0001900 RO:0001901 property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:Componency is_a: BFO:0000051 ! has part [Typedef] id: RO:0002211 name: regulates def: "process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2." [] property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000116 "We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "David Hill" xsd:string property_value: IAO:0000117 "Tanya Berardini" xsd:string property_value: IAO:0000119 "GO" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000232 "Regulation precludes parthood; the regulatory process may not be within the regulated process." xsd:string property_value: IAO:0000589 "regulates (processual)" xsd:string property_value: IAO:0000600 "false" xsd:boolean domain: BFO:0000015 ! process range: BFO:0000015 ! process holds_over_chain: RO:0002578 RO:0002578 is_transitive: true is_a: RO:0002411 ! causally upstream of inverse_of: RO:0002334 ! regulated by [Typedef] id: RO:0002212 name: negatively regulates def: "Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "negatively regulates (process to process)" xsd:string property_value: RO:0004050 RO:0002211 is_a: RO:0002211 ! regulates is_a: RO:0002305 ! causally upstream of, negative effect inverse_of: RO:0002335 ! negatively regulated by [Typedef] id: RO:0002213 name: positively regulates def: "Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "positively regulates (process to process)" xsd:string property_value: RO:0004049 RO:0002211 holds_over_chain: RO:0002212 RO:0002212 is_transitive: true is_a: RO:0002211 ! regulates is_a: RO:0002304 ! causally upstream of, positive effect inverse_of: RO:0002336 ! positively regulated by [Typedef] id: RO:0002215 name: capable of def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " [] subset: ro-eco property_value: IAO:0000112 "mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)" xsd:string property_value: IAO:0000112 "osteoclast SubClassOf 'capable of' some 'bone resorption'" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "has function realized in" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20123131 property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/21208450 property_value: IAO:0000232 "For compatibility with BFO, this relation has a shortcut definition in which the expression \"capable of some P\" expands to \"bearer_of (some realized_by only P)\"." xsd:string domain: BFO:0000004 ! independent continuant range: BFO:0000015 ! process is_a: RO:0002216 ! capable of part of expand_expression_to: "RO_0000053 some (RO_0000054 only ?Y)" [] [Typedef] id: RO:0002216 name: capable of part of def: "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "has function in" xsd:string property_value: seeAlso defining-property-chains-involving-reflexivity holds_over_chain: RO:0002215 part_of {RO:0002582="true"} is_a: RO:0002328 ! functionally related to is_a: RO:0002500 ! causal agent in process expand_expression_to: "RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y))" [] [Typedef] id: RO:0002217 name: actively participates in def: "x actively participates in y if and only if x participates in y and x realizes some active role" [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "agent in" xsd:string is_a: RO:0000056 ! participates in inverse_of: RO:0002218 ! has active participant [Typedef] id: RO:0002218 name: has active participant def: "x has participant y if and only if x realizes some active role that inheres in y" [] subset: ro-eco property_value: IAO:0000112 "'heart development' has active participant some Shh protein" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000116 "This may be obsoleted and replaced by the original 'has agent' relation" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "has agent" xsd:string is_a: RO:0000057 ! has participant [Typedef] id: RO:0002222 name: temporally related to comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. subset: ro-eco property_value: http://purl.org/dc/elements/1.1/source "https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1" xsd:anyURI property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 https://en.wikipedia.org/wiki/Allen%27s_interval_algebra property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends." xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent [Typedef] id: RO:0002263 name: acts upstream of def: "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." [] property_value: IAO:0000112 "A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision." xsd:string property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of holds_over_chain: RO:0002327 RO:0002411 is_a: RO:0002264 ! acts upstream of or within [Typedef] id: RO:0002264 name: acts upstream of or within def: "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." [] synonym: "affects" RELATED [] property_value: IAO:0000112 "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway." xsd:string property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within holds_over_chain: RO:0002327 RO:0002418 is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002304 name: causally upstream of, positive effect comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y property_value: http://purl.org/dc/elements/1.1/creator "cjm" xsd:string property_value: RO:0004049 RO:0002411 is_a: RO:0002411 ! causally upstream of is_a: RO:0004047 ! causally upstream of or within, positive effect [Typedef] id: RO:0002305 name: causally upstream of, negative effect comment: holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y property_value: http://purl.org/dc/elements/1.1/creator "cjm" xsd:string property_value: RO:0004050 RO:0002411 is_a: RO:0002411 ! causally upstream of is_a: RO:0004046 ! causally upstream of or within, negative effect [Typedef] id: RO:0002323 name: mereotopologically related to def: "A mereological relationship or a topological relationship" [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships" xsd:string property_value: RO:0001900 RO:0001901 [Typedef] id: RO:0002327 name: enables property_value: IAO:0000112 "a particular instances of akt-2 enables some instance of protein kinase activity" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "catalyzes" xsd:string property_value: IAO:0000118 "executes" xsd:string property_value: IAO:0000118 "has" xsd:string property_value: IAO:0000118 "is catalyzing" xsd:string property_value: IAO:0000118 "is executing" xsd:string property_value: IAO:0000232 "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized." xsd:string property_value: IAO:0000232 "This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time." xsd:string is_a: RO:0002215 ! capable of inverse_of: RO:0002333 ! enabled by transitive_over: BFO:0000051 ! has part transitive_over: RO:0002017 ! has component activity [Typedef] id: RO:0002328 name: functionally related to def: "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000232 "This is a grouping relation that collects relations used for the purpose of connecting structure and function" xsd:string [Typedef] id: RO:0002329 name: part of structure that is capable of def: "this relation holds between c and p when c is part of some c', and c' is capable of p." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "false" xsd:boolean holds_over_chain: part_of RO:0002215 {RO:0002581="true"} is_a: RO:0002328 ! functionally related to [Typedef] id: RO:0002331 name: involved in def: "c involved_in p if and only if c enables some process p', and p' is part of p" [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "actively involved in" xsd:string property_value: IAO:0000118 "enables part of" xsd:string property_value: seeAlso Involved:in holds_over_chain: RO:0002327 part_of is_a: RO:0002217 ! actively participates in is_a: RO:0002431 ! involved in or involved in regulation of transitive_over: part_of ! part of [Typedef] id: RO:0002333 name: enabled by def: "inverse of enables" [] property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002328 ! functionally related to [Typedef] id: RO:0002334 name: regulated by def: "inverse of regulates" [] subset: RO:0002259 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000589 "regulated by (processual)" xsd:string domain: BFO:0000015 ! process range: BFO:0000015 ! process is_transitive: true is_a: RO:0002427 ! causally downstream of or within [Typedef] id: RO:0002335 name: negatively regulated by def: "inverse of negatively regulates" [] subset: RO:0002259 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002334 ! regulated by [Typedef] id: RO:0002336 name: positively regulated by def: "inverse of positively regulates" [] subset: RO:0002259 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002334 ! regulated by [Typedef] id: RO:0002352 name: input of def: "inverse of has input" [] subset: ro-eco subset: RO:0002259 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0000056 ! participates in is_a: RO:0002328 ! functionally related to [Typedef] id: RO:0002353 name: output of def: "inverse of has output" [] subset: ro-eco subset: RO:0002259 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0000056 ! participates in is_a: RO:0002328 ! functionally related to [Typedef] id: RO:0002404 name: causally downstream of def: "inverse of upstream of" [] property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: preceded_by ! preceded by is_a: RO:0002427 ! causally downstream of or within inverse_of: RO:0002411 ! causally upstream of [Typedef] id: RO:0002405 name: immediately causally downstream of property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002087 ! immediately preceded by is_a: RO:0002404 ! causally downstream of inverse_of: RO:0002412 ! immediately causally upstream of [Typedef] id: RO:0002410 name: causally related to def: "This relation groups causal relations between material entities and causal relations between processes" [] property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000116 "This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.\n\nTo define causal relations in an activity-flow type network, we make use of 3 primitives:\n\n * Temporal: how do the intervals of the two occurrents relate? \n * Is the causal relation regulatory?\n * Is the influence positive or negative\n\nThe first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.\n\nFor the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.\n\nFor the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.\n\nEach of these 3 primitives can be composed to yield a cross-product of different relation types." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string [Typedef] id: RO:0002411 name: causally upstream of def: "p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain" [] property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string is_transitive: true is_a: BFO:0000063 ! precedes is_a: RO:0002418 ! causally upstream of or within [Typedef] id: RO:0002412 name: immediately causally upstream of def: "p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q." [] property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: RO:0002575 RO:0002411 is_a: RO:0002090 ! immediately precedes is_a: RO:0002411 ! causally upstream of [Typedef] id: RO:0002418 name: causally upstream of or within def: "p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q." [] synonym: "affects" RELATED [] property_value: IAO:0000116 "We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "influences (processual)" xsd:string is_transitive: true is_a: RO:0002501 ! causal relation between processes inverse_of: RO:0002427 ! causally downstream of or within [Typedef] id: RO:0002427 name: causally downstream of or within def: "inverse of causally upstream of or within" [] subset: RO:0002259 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations is_transitive: true is_a: RO:0002501 ! causal relation between processes [Typedef] id: RO:0002428 name: involved in regulation of def: "c involved in regulation of p if c is involved in some p' and p' regulates some p" [] property_value: IAO:0000117 "Chris Mungall" xsd:string holds_over_chain: RO:0002327 RO:0002211 holds_over_chain: RO:0002331 RO:0002211 is_a: RO:0002263 ! acts upstream of is_a: RO:0002431 ! involved in or involved in regulation of [Typedef] id: RO:0002429 name: involved in positive regulation of def: "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: RO:0004049 RO:0002428 holds_over_chain: RO:0002327 RO:0002213 holds_over_chain: RO:0002331 RO:0002213 is_a: RO:0002428 ! involved in regulation of [Typedef] id: RO:0002430 name: involved in negative regulation of def: "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: RO:0004050 RO:0002428 holds_over_chain: RO:0002327 RO:0002212 holds_over_chain: RO:0002331 RO:0002212 is_a: RO:0002428 ! involved in regulation of [Typedef] id: RO:0002431 name: involved in or involved in regulation of def: "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" [] property_value: IAO:0000116 "OWL does not allow defining object properties via a Union" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "involved in or reguates" xsd:string is_a: RO:0002264 ! acts upstream of or within is_a: RO:0002328 ! functionally related to is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002432 name: is active in def: "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." [GOC:cjm, GOC:dos] synonym: "enables activity in" EXACT [] property_value: IAO:0000112 "A protein that enables activity in a cytosol." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "executes activity in" xsd:string holds_over_chain: RO:0002327 BFO:0000066 {RO:0002581="true"} is_a: RO:0002131 ! overlaps is_a: RO:0002328 ! functionally related to [Typedef] id: RO:0002434 name: interacts with def: "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." [] subset: ro-eco synonym: "in pairwise interaction with" EXACT [] property_value: http://xmlns.com/foaf/0.1/page "https://github.com/oborel/obo-relations/wiki/InteractionRelations" xsd:anyURI property_value: IAO:0000116 "Considering relabeling as 'pairwise interacts with'" xsd:anyURI property_value: IAO:0000116 "This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000232 "Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules." xsd:string property_value: seeAlso "http://purl.obolibrary.org/obo/MI_0914" xsd:anyURI domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_symmetric: true [Typedef] id: RO:0002436 name: molecularly interacts with def: "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "binds" xsd:string property_value: IAO:0000118 "molecularly binds with" xsd:string property_value: seeAlso ECO:0000353 property_value: seeAlso "http://purl.obolibrary.org/obo/MI_0915" xsd:anyURI is_symmetric: true is_a: RO:0002434 ! interacts with [Typedef] id: RO:0002447 name: phosphorylates property_value: IAO:0000116 "Axiomatization to GO to be added later" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y." xsd:string is_a: RO:0002436 ! molecularly interacts with [Typedef] id: RO:0002448 name: activity directly regulates activity of def: "Holds between molecular entities A and B where A can physically interact with B and in doing so regulates a process that B is capable of. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B." [] synonym: "molecularly controls" EXACT [] property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002436 ! molecularly interacts with is_a: RO:0002566 ! causally influences [Typedef] id: RO:0002449 name: activity directly negatively regulates activity of def: "Holds between molecular entities A and B where A can physically interact with B and in doing so negatively regulates a process that B is capable of. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B." [] synonym: "molecularly decreases activity of" EXACT [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "inhibits" xsd:string is_a: RO:0002448 ! activity directly regulates activity of [Typedef] id: RO:0002450 name: activity directly positively regulates activity of def: "Holds between molecular entities A and B where A can physically interact with B and in doing so positively regulates a process that B is capable of. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B." [] synonym: "molecularly increases activity of" EXACT [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "activates" xsd:string is_a: RO:0002448 ! activity directly regulates activity of [Typedef] id: RO:0002464 name: helper property (not for use in curation) property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000232 "This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning." xsd:string [Typedef] id: RO:0002479 name: has part that occurs in def: "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." [] subset: ro-eco property_value: IAO:0000117 "Chris Mungall" xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000004 ! independent continuant holds_over_chain: BFO:0000051 BFO:0000066 {RO:0002581="true"} [Typedef] id: RO:0002481 name: is kinase activity property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002564 ! molecular interaction relation helper property [Typedef] id: RO:0002500 name: causal agent in process def: "A relationship between a material entity and a process where the material entity has some causal role that influences the process" [] property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations is_a: RO:0002595 ! causal relation between material entity and a process inverse_of: RO:0002608 ! process has causal agent [Typedef] id: RO:0002501 name: causal relation between processes def: "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002506 name: causal relation between material entities property_value: IAO:0000116 "The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002559 name: causally influenced by property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "causally influenced by (material entity to material entity)" xsd:string is_a: RO:0002506 ! causal relation between material entities inverse_of: RO:0002566 ! causally influences [Typedef] id: RO:0002563 name: interaction relation helper property property_value: http://xmlns.com/foaf/0.1/page "https://github.com/oborel/obo-relations/wiki/InteractionRelations" xsd:anyURI property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:N-Ary_Relation_Pattern_%28OWL_2%29 is_a: RO:0002464 ! helper property (not for use in curation) [Typedef] id: RO:0002564 name: molecular interaction relation helper property property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002563 ! interaction relation helper property [Typedef] id: RO:0002566 name: causally influences def: "Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b" [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "causally influences (material entity to material entity)" xsd:string is_a: RO:0002506 ! causal relation between material entities [Typedef] id: RO:0002578 name: directly regulates def: "Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "directly regulates (processual)" xsd:string property_value: RO:0002575 RO:0002211 is_a: RO:0002211 ! regulates is_a: RO:0002412 ! immediately causally upstream of [Typedef] id: RO:0002584 name: has part structure that is capable of def: "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" [] property_value: IAO:0000112 "gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string holds_over_chain: BFO:0000051 RO:0002215 is_a: RO:0002328 ! functionally related to is_a: RO:0002595 ! causal relation between material entity and a process [Typedef] id: RO:0002595 name: causal relation between material entity and a process def: "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." [] property_value: IAO:0000116 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations domain: BFO:0000040 ! material entity range: BFO:0000015 ! process is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002596 name: capable of regulating def: "Holds between c and p if and only if c is capable of some activity a, and a regulates p." [] property_value: IAO:0000112 "pyrethroid -> growth" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations holds_over_chain: RO:0002215 RO:0002211 is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002597 name: capable of negatively regulating def: "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." [] property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations holds_over_chain: RO:0002215 RO:0002212 is_a: RO:0002596 ! capable of regulating [Typedef] id: RO:0002598 name: capable of positively regulating def: "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." [] property_value: IAO:0000112 "renin -> arteriolar smooth muscle contraction" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations holds_over_chain: RO:0002215 RO:0002213 is_a: RO:0002596 ! capable of regulating [Typedef] id: RO:0002608 name: process has causal agent def: "Inverse of 'causal agent in process'" [] property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002629 name: directly positively regulates def: "Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2." [] property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "directly positively regulates (process to process)" xsd:string property_value: RO:0004049 RO:0002578 is_a: RO:0002213 ! positively regulates is_a: RO:0002578 ! directly regulates [Typedef] id: RO:0002630 name: directly negatively regulates def: "Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2." [] property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "directly negatively regulates (process to process)" xsd:string property_value: RO:0004050 RO:0002578 is_a: RO:0002212 ! negatively regulates is_a: RO:0002578 ! directly regulates [Typedef] id: RO:0003000 name: produces def: "a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix." [] comment: Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue. subset: ro-eco property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Melissa Haendel" xsd:string domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity inverse_of: RO:0003001 ! produced by [Typedef] id: RO:0003001 name: produced by def: "a produced_by b iff some process that occurs_in b has_output a." [] subset: ro-eco property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Melissa Haendel" xsd:string domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity [Typedef] id: RO:0004031 name: enables subfunction def: "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." [] holds_over_chain: RO:0002327 BFO:0000051 is_a: RO:0002328 ! functionally related to created_by: cjm creation_date: 2018-01-25T23:20:13Z [Typedef] id: RO:0004032 name: acts upstream of or within, positive effect property_value: RO:0004049 RO:0002264 property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect holds_over_chain: RO:0002327 RO:0004047 is_a: RO:0002264 ! acts upstream of or within created_by: cjm creation_date: 2018-01-26T23:49:30Z [Typedef] id: RO:0004033 name: acts upstream of or within, negative effect property_value: RO:0004050 RO:0002264 holds_over_chain: RO:0002327 RO:0004046 is_a: RO:0002264 ! acts upstream of or within created_by: cjm creation_date: 2018-01-26T23:49:51Z [Typedef] id: RO:0004034 name: acts upstream of, positive effect def: "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" [] property_value: RO:0004049 RO:0002263 property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect holds_over_chain: RO:0002327 RO:0002304 is_a: RO:0002263 ! acts upstream of is_a: RO:0004032 ! acts upstream of or within, positive effect created_by: cjm creation_date: 2018-01-26T23:53:14Z [Typedef] id: RO:0004035 name: acts upstream of, negative effect def: "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" [] property_value: RO:0004050 RO:0002263 property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect holds_over_chain: RO:0002327 RO:0002305 is_a: RO:0002263 ! acts upstream of is_a: RO:0004033 ! acts upstream of or within, negative effect created_by: cjm creation_date: 2018-01-26T23:53:22Z [Typedef] id: RO:0004046 name: causally upstream of or within, negative effect property_value: RO:0004050 RO:0002418 is_a: RO:0002418 ! causally upstream of or within created_by: cjm creation_date: 2018-03-13T23:55:05Z [Typedef] id: RO:0004047 name: causally upstream of or within, positive effect property_value: RO:0004049 RO:0002418 is_a: RO:0002418 ! causally upstream of or within created_by: cjm creation_date: 2018-03-13T23:55:19Z [Typedef] id: has_connecting_compound name: has connecting compound [Typedef] id: has_input_compound name: has input def: "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." [] subset: ro-eco xref: RO:0002233 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "consumes" xsd:string domain: BFO:0000015 ! process range: BFO:0000040 ! material entity is_a: RO:0000057 ! has participant inverse_of: RO:0002352 ! input of [Typedef] id: has_output_compound name: has output def: "p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p." [] subset: ro-eco xref: RO:0002234 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "produces" xsd:string is_a: RO:0000057 ! has participant inverse_of: RO:0002353 ! output of [Typedef] id: part_of name: part of def: "a core relation that holds between a part and its whole" [] xref: BFO:0000050 property_value: IAO:0000111 "is part of" xsd:string property_value: IAO:0000112 "my brain is part of my body (continuant parthood, two material entities)" xsd:string property_value: IAO:0000112 "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)" xsd:string property_value: IAO:0000112 "this day is part of this year (occurrent parthood)" xsd:string property_value: IAO:0000116 "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other." xsd:string property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string property_value: IAO:0000116 "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'." xsd:string property_value: IAO:0000118 "part_of" xsd:string property_value: RO:0001900 RO:0001901 property_value: seeAlso http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:PartOf property_value: seeAlso "http://www.obofoundry.org/ro/#OBO_REL:part_of" xsd:string is_transitive: true is_a: RO:0002131 ! overlaps inverse_of: BFO:0000051 ! has part [Typedef] id: preceded_by name: preceded by def: "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco xref: BFO:0000062 property_value: http://purl.org/dc/elements/1.1/source "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" xsd:string property_value: IAO:0000111 "preceded by" xsd:string property_value: IAO:0000116 "An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other." xsd:string property_value: IAO:0000118 "is preceded by" xsd:string property_value: IAO:0000118 "preceded_by" xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent holds_over_chain: part_of preceded_by is_transitive: true is_a: RO:0002086 ! ends after inverse_of: BFO:0000063 ! precedes [Typedef] id: uniprot_super_pathway name: UniProt super-pathway is_metadata_tag: true is_class_level: true