Pathological structure or process mouse_pathology.ontology MPATH:0 pathological entity The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors. mouse_pathology.ontology MPATH:1 cell and tissue damage Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body. mouse_pathology.ontology MPATH:105 circulatory disorder Abnormal release of whole blood or the cellular component from the circulation. mouse_pathology.ontology MPATH:119 hemorrhage and non-specified extravasation A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae. mouse_pathology.ontology MPATH:120 May also be used for any organ, although more generally used with respect to the skin. ecchymosis A localised deposition of clotted or partially clotted extravasated blood. mouse_pathology.ontology Bruise MPATH:121 hematoma An area of necrosis resulting from a sudden cessation of arterial or venous blood supply. mouse_pathology.ontology MPATH:124 infarct Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs. mouse_pathology.ontology MPATH:126 growth and differentiation defect A reduction in size of organs or tissues as a result of cell death, loss of cellularity of whatever cause, reduced cellular proliferation or decreased cellular volume. mouse_pathology.ontology MPATH:127 atrophy A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell. George Gkoutos mouse_pathology.ontology MPATH:14 process of degenerative change Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia). George Gkoutos mouse_pathology.ontology epidermal hyperplasia. squamous cell hyperplasia MPATH:149 squamous hyperplasia Hyperplasia of the Malpighian layer (prickle cell) of the epidermis. George Gkoutos mouse_pathology.ontology MPATH:150 acanthosis Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis. George Gkoutos mouse_pathology.ontology cornification hyperorthokeratosis hyperparakeratosis MPATH:154 hyperkeratosis Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum. George Gkoutos mouse_pathology.ontology MPATH:156 parakeratosis Abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. An adult instance of developmental transdifferentiation MPATH:85 Traditionally defined as a form of abnormal regeneration in which a type of cell different from that found normally in a given location is produced. George Gkoutos mouse_pathology.ontology MPATH:160 metaplasia Metaplasia occurring within epithelia. George Gkoutos mouse_pathology.ontology MPATH:162 epithelial metaplasia Appearance of heterotopic gastric epithelium. George Gkoutos mouse_pathology.ontology MPATH:164 gastric metaplasia The process, normal or abnormal, of damage repair or wound closure. George Gkoutos mouse_pathology.ontology MPATH:175 healing and repair process Replacement of connective tissue by fibro-fatty deposits and scar tissue. George Gkoutos mouse_pathology.ontology MPATH:176 connective tissue replacement Reactive formation of fibrous tissue. George Gkoutos mouse_pathology.ontology MPATH:181 fibrosis Any pathological thickening or hardening of a tissue. George Gkoutos mouse_pathology.ontology Induration MPATH:184 sclerosis Inappropriate or aberrant activation or suppression of the immune or inflammatory response. George Gkoutos mouse_pathology.ontology MPATH:188 immunopathological process Tissue response to inappropriate immune/inflammatory process. George Gkoutos mouse_pathology.ontology MPATH:194 immune mediated disease Inflammation of a joint. George Gkoutos mouse_pathology.ontology MPATH:195 arthritis Inflammation of the skin. George Gkoutos mouse_pathology.ontology MPATH:196 dermatitis Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment. George Gkoutos mouse_pathology.ontology MPATH:197 glomerulonephritis An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction. George Gkoutos mouse_pathology.ontology MPATH:198 immune mediated hemolytic anaemia Complete and irreversible cessation of metabolic activity. George Gkoutos mouse_pathology.ontology MPATH:2 cell death Inflammation of a muscle. George Gkoutos mouse_pathology.ontology Initis MPATH:200 myositis Inflammation of a blood vessel. George Gkoutos mouse_pathology.ontology angiitis arteritis lymphangiitis phlebitis MPATH:201 vasculitis A tissue reaction to an internal or external injury. George Gkoutos mouse_pathology.ontology MPATH:212 inflammation Inflammation with a recent onset, characterised histologically by primarily granulocyte infiltration, edema and hyperemia. George Gkoutos mouse_pathology.ontology MPATH:213 The five classical signs of inflammation: Rubor, tumor, calor, dolor, functio laesa (Galen 300BC). acute inflammation Chronic inflammatory condition characterised by infiltration of primarily lymphocytes. George Gkoutos mouse_pathology.ontology MPATH:214 chronic inflammation A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant. George Gkoutos mouse_pathology.ontology MPATH:218 neoplasm Tumors of the skin, its constituent structures and glands including the mammary gland, apocrine and eccrine glands, hair follicles and associated structures. George Gkoutos mouse_pathology.ontology MPATH:219 adnexal and skin appendage tumor Multiple small benign nodules derived from basal cells of hair follicles enclosing small cornified cell containing cysts. (M-8100/0). mouse_pathology.ontology Epithelioma adenoides cysticum benign hair follicle tumor MPATH:232 trichoepithelioma Well circumscribed tumor of the basal cells of the epidermis. Rare mitotic figures, benign. (M8147/0). mouse_pathology.ontology Benign basal cell tumor basal cell adenoma MPATH:233 basal cell tumor Malignant neoplasm of the basal cells of the epidermis with local invasion. (M-8090/3). mouse_pathology.ontology MPATH:234 basal cell carcinoma Tumor of venous or arterial vessels or capillaries. mouse_pathology.ontology MPATH:235 blood vessel tumor .A benign neoplasm of fibrous tissue in which there are multiple large and small dilated vascular channels ( M9160/0). mouse_pathology.ontology Telangiectatic fibroma MPATH:236 angiofibroma A benign neoplasm frequently arising in the cerebellum composed of capillary vessel forming endothelial cells and stromal cells. (M-9161/1). mouse_pathology.ontology Angioblastoma MPATH:238 hemangioblastoma Neoplasm derived from endothelial cells. May be of capillary or cavernous type with large vascular channels. (M-9130/0 + M-9120/0 respectively). mouse_pathology.ontology Angioendothelioma. Hemangioendothelioma, benign MPATH:240 hemangioma Malignant neoplasm derived from pluripotential mesenchymal stem cells or endothelial cells of blood vessels. (M-9120/3). mouse_pathology.ontology Hemangioma malignant hemangioendothelioma malignant, angiosarcoma hemangioendothelioma malignant. MPATH:242 hemangiosarcoma Neoplasm of the neurones, glia or meninges of the CNS. mouse_pathology.ontology MPATH:243 central nervous system tumor Glioma derived from astrocytes, both benign and malignant forms (M-9400/3). mouse_pathology.ontology Astrocytic glioma astroglioma MPATH:244 Also see comments in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. astrocytoma Benign neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/0). mouse_pathology.ontology MPATH:246 choroid plexus papilloma Neoplasm derived from the ependymal cells lining the ventricles and aqueduct of the brain and the central canal of the spinal cord. Malignant or benign. (M-9391/3). mouse_pathology.ontology MPATH:247 Also see general scheme in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. ependymoma Neoplasm derived from astrocytes and oligodendrocytes. (M-9380/3, M-9440/3). mouse_pathology.ontology MPATH:249 Also see comments in: Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. glioma Degenerative process characteristic of a particular tissue. mouse_pathology.ontology MPATH:25 tissue specific degenerative process Neoplasm derived from the primitive neurectodermal cells of the cerebellum. (M-9470/3). May be considered by some authorities a synonym of PNET in the CNS. mouse_pathology.ontology MPATH:250 Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. medulloblastoma meningioma mouse_pathology.ontology Sarcoma, meningeal ( sensu malignant tumor) MPATH:251 Benign or malignant neoplasm derived from the meninges. (M-9530/0). meningioma Benign or malignant neoplasm derived form oligodendrocytes (M-9450/3). mouse_pathology.ontology Glioma, oligodendritic, benign glioma oligodendritic, malignant MPATH:252 Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. oligodendroglioma Tumors showing mutiple histological componants/differentiation. mouse_pathology.ontology MPATH:254 complex tumor Embryonal tumor thought to be derived from metanephric blastema. Mono, bi or triphasic, sometimes with heterotypic differentiation. (M-8960/3). mouse_pathology.ontology nephroma MPATH:261 nephroblastoma A biphasic tumor containing a primitive epithelial component, that may resemble well-differentiated fetal adenocarcinoma and a primitive mesenchymal stroma, which occasionally has foci of osteosarcoma, chondrosarcoma or rhadomyosarcoma. (M-8972/3). mouse_pathology.ontology MPATH:262 pulmonary blastoma Tumors with epithelial invaginations/linings and a fibrillary and fibrocytic stroma. (M-9000 - M-9030). mouse_pathology.ontology MPATH:264 fibroepithelial tumor A benign neoplasm derived from glandular epithelium, in which there is a abundant stroma of proliferating fibroblasts and connective tissue. (M-9010/0). mouse_pathology.ontology MPATH:266 fibroadenoma Neoplasms derived from glandular epithelial cells. mouse_pathology.ontology MPATH:267 glandular tumor Malignant neoplasm of epithelial cells in glandular or glandlike pattern. (M-8140/3). mouse_pathology.ontology MPATH:268 adenocarcinoma Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process. mouse_pathology.ontology Degenerative joint disease osteoarthrosis MPATH:27 arthrosis A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy. mouse_pathology.ontology MPATH:270 adenoma Spontaneous intestinal adenoma formation. Polyps increase in number, causing symptoms of chronic colitis and potentially transform into adenocarcinoma. (M-8220/0). mouse_pathology.ontology MPATH:271 adenomatous polyposis coli A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/0). mouse_pathology.ontology MPATH:277 cystadenoma Originates in the follicular cells of thyroid follicles. Papillary, solid and follicular forms. (M- 8330/3). mouse_pathology.ontology Follicular carcinoma MPATH:278 follicular adenocarcinoma Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification. mouse_pathology.ontology MPATH:28 Note that in mouse and rats the initial lesions are mostly in the medial layer while in human they occur in the intima. atherosclerosis Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0). mouse_pathology.ontology Adenoma, endocrine pancreas adenomatosis islet (pancreatic) cell tumor benign MPATH:287 islet cell adenoma Derived from calcitonin-producing cells (thyroid). In humans a type of carcinoma composed of epithelial elements with considerable lymphoid stroma (breast). Not yet reported in mice. (M-8510/3). mouse_pathology.ontology Medullary adenocarcinoma MPATH:291 medullary carcinoma A malignant neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/3). mouse_pathology.ontology MPATH:295 papillary adenocarcinoma A benign neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/0). mouse_pathology.ontology MPATH:298 papillary cystadenoma Originating from differentiated cells of the pineal parenchyma. Not to be confused with human pinealoma (syn: germinoma) non-gonadal germ cell tumors found in the pineal believed to be atypical teratomas. May be benign or malignant. If ectopic teratomas/teratocarcinomas use MP322 or MP321. (M-9360/1). mouse_pathology.ontology MPATH:299 pinealoma Malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland. (M-8510/3, M-8345/3). mouse_pathology.ontology Medullary carcinoma, parafollicular cell tumor c-cell malignant MPATH:308 thyroid C-cell carcinoma Germ cell and non-germ cell tumors of the testis and ovary. mouse_pathology.ontology MPATH:309 gonadal tumor Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number. mouse_pathology.ontology MPATH:31 emphysema Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells. mouse_pathology.ontology MPATH:310 germ cell tumor Undifferentiated germ cell tumor of the ovary composed of solid sheets of large polygonal cells with rim of clear cytoplasm (M-9060/3). mouse_pathology.ontology Seminoma (sensu male) MPATH:312 dysgerminoma Gonadal neoplasms that consist of aggregates of germ cells and sex cord elements (M-9073/1). mouse_pathology.ontology Gonocytoma MPATH:315 gonadoblastoma Malignant neoplasm of the testis/ovary including various elements of germ cell tumors (M-9085/3). mouse_pathology.ontology Mixed teratoma and seminoma MPATH:316 mixed germ cell tumor Tumor derived from spermatogenic cells resembling spermatogenia or spermatocytes. NOS ( M9061/3). mouse_pathology.ontology Germinoma, malignant dysgerminoma spermatoblastoma spermatocytoma, malignant. MPATH:317 seminoma Mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma (M-9081/3). mouse_pathology.ontology MPATH:321 teratocarcinoma Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1). mouse_pathology.ontology MPATH:322 teratoma Neoplasms derived from the non-germ cell derived tissues of the testis and ovary. mouse_pathology.ontology MPATH:323 gonadal somatic cell tumor Tumor derived from Leydig cells (M-8650/1). mouse_pathology.ontology Interstitial cell tumor, benign Leydig cell adenoma MPATH:328 leydig cell tumor Accumulation of substances within, on the surface of or between cells. mouse_pathology.ontology MPATH:33 intracellular and extracellular accumulation Tumor derived from sex cord/stromal cells; Sertoli cells and can occur in both testis and ovary. (M-8640/1). mouse_pathology.ontology Androblastoma arrhenoblastoma gonadal stromal tumor sex cord stromal tumor sustentacluar tumor MPATH:331 sertoli cell tumor Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages. mouse_pathology.ontology MPATH:335 hematopoietic/lymphoid malignancies/disorder Extracellular deposition of amyloid protein. mouse_pathology.ontology Amyloidosis MPATH:34 Any group of chemically diverse proteins that appears microscopically homogeneous, but is composed of linear non-branching aggregated fibrils aranged in sheets when see under the electron microscope. amyloid deposition Leukaemias of the myeloid lineage. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology granulocytic leukaemia MPATH:342 myeloid leukaemia George Gkoutos 2011-03-22T01:12:01Z mouse_pathology.ontology MPATH:346 autoimmune mediated disease A neoplasm in the anterior mediastinum, originating from thymic tissue, usually benign, and frequently encapsulated; occasionally invasive, but metastases are rare; histologically, consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. (M-8580/1). mouse_pathology.ontology MPATH:351 thymoma Tumors of the liver and biliary apparatus. mouse_pathology.ontology MPATH:352 hepatic tumor Benign neoplasm derived from hepatocytes. (M- 8170/0). mouse_pathology.ontology hepatic adenoma, benign, liver cell tumor, benign hepatoma, benign nodule type A MPATH:353 hepatocellular adenoma Malignant tumor derived from the bile duct epithelium. (M8160/3). mouse_pathology.ontology MPATH:354 cholangiocarcinoma Malignant neoplasm of the liver of unknown origin . Liver blastemal cells, neoplastic hepatocytes, oval cells and biliary epithelial cells have been proposed. (M- 8970/3). mouse_pathology.ontology embryonal hepatoma tumor, mixed, poorly differentiated MPATH:356 hepatoblastoma Malignant tumor derived from hepatocytes. (M- 8170/3). mouse_pathology.ontology carcinoma, trabecular carcinoma, trabecular (liver) hepatoma, malignant nodule type B MPATH:357 hepatocellular carcinoma Tumors derived from melanocytes. mouse_pathology.ontology MPATH:358 melanocytic tumor Tumor of neurectodermal origin, usually melanocytes, showing dense deposition of melanin granules, although amelanotic melanomas have been reported. (M-8720/3). URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/malignant_melanoma#melanoma_table mouse_pathology.ontology melanosarcoma melanosarcoma, malignant melanoma MPATH:359 melanoma Intra or extracellular deposition of calcium usually as calcium phosphate. mouse_pathology.ontology MPATH:36 calcium deposition A potentially malignant lesion, melanoma in situ is the first phase of growth of melanoma, in which it is still confined to the epithelial domain (epidermis and adnexa) and has not passed through the basement membrane. (M-8720/2). mouse_pathology.ontology level I melanoma MPATH:360 melanoma in situ Local lesion of the skin, often colored by hyperpigmentation or increased vascularity. May be predominantly epidermal, adnexal, melanocytic, vascular, or mesodermal, or a compound overgrowth of these tissues. Not necessarily pre-malignant. (M-8720/0). mouse_pathology.ontology mole (sensu melanocytic nevus) MPATH:361 naevus Benign or malignant neoplasm derived from the lining cells of the pleura and peritoneum, composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells. Epithelioid, fibrous, cystis, papillary, and sarcomatoid variants. (M- 9050/3). mouse_pathology.ontology MPATH:365 mesothelioma Neoplasms derived from the neuroendocrine system. mouse_pathology.ontology MPATH:366 neuroendocrine tumor Primitive neuroectodermal tumors (PNET) are neoplasms derived from primitive neural stem cells either in the CNS or the periphery . These are small-cell, malignant embryonal tumors showing divergent differentiation of variable degree along neuronal, glial, or rarely mesenchymal lines. (M-9473/3, M-9364/3). mouse_pathology.ontology PNET MPATH:370 primitive neurectodermal tumor Neuroendocrine cell derived anaplastic carcinoma composed of small cells, usually of the lung producing a variety of peptide hormones. (M-8041/3). 1.2.3.4 of MMHCC classification. URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass mouse_pathology.ontology oat cell carcinoma MPATH:371 see: Meuwissen, R., Linn, S.C., Linnoila, R.I. et al. (2003) Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer cell, 4: 181-189. AND Calbo, J., Meuwissen, R., van Montfort, E. et al. (2005) Genotype-phenotype relationships in a mouse model for human small-cell lung cancer. Cold Spring Harbor symposia on quantitative biology, 70: 225-232. AND Meuwissen, R. and Berns, A. (2005) Mouse models for human lung cancer. Genes & development, 19: 643-664. small cell carcinoma Neoplasms derived from neuroepithelial precursors. mouse_pathology.ontology MPATH:373 Renamed from neuroepitheliomatous tumor, to reflect primitive origins of this class of tumor. CNS progenitor tumor A benign neoplasm composed of mature ganglionic neurons scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers. (M-9490/0). mouse_pathology.ontology MPATH:375 ganglioneuroma A malignant neoplasm characterized by immature, poorly differentiated nerve cells of embryonic type. (M-9500/3). mouse_pathology.ontology MPATH:376 neuroblastoma A catecholamine-secreting tumor arising from the chromaffin cells of the sympathetic nervous system or adrenal medulla. May be benign or malignant. [See MPATH 398]. (M- 8510/3). mouse_pathology.ontology MPATH:377 pheochromocytoma Malignant juvenile neoplasm of the eye derived from primitive retinal precursor cells. (M- 9510/3). mouse_pathology.ontology MPATH:378 retinoblastoma Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) . mouse_pathology.ontology MPATH:379 odontogenic tumor Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0). mouse_pathology.ontology MPATH:387 odontoma Neoplasms of bone and cartilage. mouse_pathology.ontology MPATH:388 osseous and chondromatous tumor Malignant neoplasm derived form pluripotential mesenchymal cells, chondrocytes or chondroblasts. No production of osteoid. (M-9220/3). mouse_pathology.ontology MPATH:392 chondrosarcoma Benign neoplasm derived from osteoblasts or osteocytes composed of very dense bone with predominantly woven structure. ( M-9180/0). mouse_pathology.ontology cancellous osteoma compact osteoma juxtacortical osteoma medullary osteoma osteoid osteoma spongious osteoma trabecular osteoma MPATH:396 osteoma Malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes. Highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone. (M-9180/3). mouse_pathology.ontology osteogenic sarcoma MPATH:397 osteosarcoma Generally benign neoplasms of CHIEF cells arising from neuroectodermal tissues, found in various parts of the body. Note that until recently, glomus tumors were believed to be derived from specialised vascular cells, which is incorrect. Paraganglioma is the preferred term.The nomenclature for pheochromocytoma and paraganglioma is inconsistent. The term paraganglioma is used to refer to any extra-adrenal tumor of the paraganglion system or nonfunctional tumor of the paraganglion system. Functional tumors are referred extra-adrenal pheochromocytoma. mouse_pathology.ontology MPATH:398 paragangliomas and glomus tumor Morpholological changes after intravital (Pathologic) death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage;characterised by mitochondrial swelling, nuclear pyknosis, karyolysis, swollen and abnormally pale basophilic staining; or karyorrhexis, rupture and fragmentation of the nucleus. Energy independent cf. Apoptosis MPATH 3. mouse_pathology.ontology MPATH:4 necrosis A neoplasm composed of derivatives of CHIEF cells usually in single encapsulated nodular masses surrounded with sustentacular cells. ( M- 8711/0). mouse_pathology.ontology chemodectomas glomus tumor non-chromaffin paragangliomas MPATH:403 paraganglioma Neoplasms of the soft and connective tissues. mouse_pathology.ontology MPATH:404 soft tissue tumor Believed to arise from primitive notochord remnants . Usually occurs along the axial skeleton and is characterised by the presence of bubble cells containing large unstained cytoplasmic vacuoles with central or eccentricc nuclei. Benign but locally invasive. (M-9370/3). mouse_pathology.ontology MPATH:405 chordoma Benign neoplasm of fibroblasts/fibrocytes with poor/moderate cellularity. (M-8810/0). mouse_pathology.ontology MPATH:407 "Soft tissue" qualifier removed by Pathology Panel to increase scope of term. fibroma Malignant tumor derived from pluripotential mesenchymal stem cells; fibroblasts, fibrocytes (M-8810/3). fibrosarcoma mouse_pathology.ontology MPATH:408 soft tissue fibrosarcoma Tumors derived from the lipogenic lineage or showing predominantly lipomatous differentiation. mouse_pathology.ontology MPATH:415 lipomatous tumor Benign renal neoplasm composed of fat, vascular, and smooth muscle elements. Associated with tuberous sclerosis in humans. Aetiology unknown, but the combination of elements may reflect a lesion specific pattern of metaplasia. (M-8860/0). mouse_pathology.ontology MPATH:416 angiomyolipoma Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous. (M- 8850/0). mouse_pathology.ontology MPATH:417 lipoma Neoplasms of the lymphatic vessels. mouse_pathology.ontology MPATH:419 lymphatic vessel tumor Benign hamartomatous malformation of the lymphatic ducts. Usually found in the skin and may be superficial or deep. (M-9170/0). Hygroma mouse_pathology.ontology MPATH:420 lymphangioma Neoplasms derived from myogenic lineages or predominantly composed of cells showing myomatous differentiation. mouse_pathology.ontology MPATH:423 myomatous tumor Benign neoplasm derived from smooth muscle cells. (M-8890/0). mouse_pathology.ontology MPATH:425 leiomyoma Malignant tumor derived form pluripotential mesenchymal stem cells or smooth muscle cells. (M- 8890/3). mouse_pathology.ontology MPATH:426 leiomyosarcoma Malignant tumor of striated muscle or pluripotential mesenchymal stem cells. (M-8900/3). mouse_pathology.ontology MPATH:428 rhabdomyosarcoma Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix. mouse_pathology.ontology MPATH:429 myxomatous tumor A benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. May show multiple differentiated components. (M-8840/0). mouse_pathology.ontology MPATH:431 myxoma Neoplasms of the nerve sheath. mouse_pathology.ontology MPATH:433 nerve sheath tumor Peripheral nerve tumor consisting of chaotic arrays of wavy schwann cell bundles and fibroblasts interspersed within a matrix rich in collagen and mucopolysaccharide. (M9540/0). mouse_pathology.ontology MPATH:435 neurofibroma Malignant neoplasm derived from Schwann cells. (M-9540/3). mouse_pathology.ontology malignant peripheral nerve sheath tumor MPATH:437 neurofibrosarcoma May be malignant or benign, Schwann cell derived tumor considered to be neurectodermal with some acquired mesenchymal features. (M-9560/0). mouse_pathology.ontology neurilemoma neurinoma, benign MPATH:438 schwannoma Neoplasms of stratified squamous epithelial cells. mouse_pathology.ontology MPATH:442 squamous cell tumor A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells (M-8050/0). mouse_pathology.ontology MPATH:445 papilloma Malignant tumor derived from stratified squamous cells. (M-8070/3). mouse_pathology.ontology carcinoma, epidermoid ( sensu epidermal derived tumors) MPATH:446 squamous cell carcinoma Neoplasms of transitional epithelia, eg kidney, ureter , bladder , cervix. mouse_pathology.ontology MPATH:450 transitional cell tumor Malignant neoplasm of transitional cells (M-8120/3). mouse_pathology.ontology MPATH:451 transitional cell carcinoma Dilation of a tubular structure. mouse_pathology.ontology MPATH:474 Often associated with an obstruction. ectasia A lesion formed by a dilated capillary or terminal artery. mouse_pathology.ontology MPATH:476 telangiectasia Benign neoplastic growth containing areas of adenomatous structure (progression). mouse_pathology.ontology polypoid adenoma, cellular polyp. MPATH:490 adenomatous polyp Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:496 Non-Lymphoid leukaemias Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:502 monocytic leukaemia Solid tumor mass composed of non-lymphoid haematopoietic cells. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:504 non-lymphoid hematopoietic sarcomas Solid tumor mass composed predominantly of histiocytic cells (M-9775/3). URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology Kupffer cell sarcoma (sensu liver) histiocytic lymphoma malignant lymphoma, histiocytic type reticulum cell sarcoma, type A reticulum cell sarcoma, type A, reticulosarcoma MPATH:506 histiocytic sarcoma Neoplasms of the B or T cell lineage. mouse_pathology.ontology MPATH:513 Lymphoid neoplasms Hematological neoplasias of non-lymphoid origin. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:515 Non-Lymphoid neoplasias Neoplasm of the B cell lymphoid lineage. mouse_pathology.ontology MPATH:516 B-cell neoplasms Lymphomas originating in peripheral B cells. mouse_pathology.ontology MPATH:519 Mature B-cell neoplasms Diffuse proliferation of mature plasma cells. Clonal by definition. Includes the equivalent of human myeloma (ICD-O 9732/3). URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/hema_models/hema_mouse_class mouse_pathology.ontology Myeloma ( human ) MPATH:530 Plasma cell neoplasms Diffuse proliferation of mature plasma cells. Clonal by definition. URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/hema_models/hema_mouse_class mouse_pathology.ontology MPATH:532 Tissue, usually lymph nodes, that contain unusually large numbers of normal appearing plasma cells. While these may be plasmacytomas, additional work is needed to confirm this latter diagnosis. plasmacytoma Neoplasms derived from cells of the T lymphocyte lineage. mouse_pathology.ontology MPATH:535 T-cell neoplasms Neoplasms of precursor T cells. mouse_pathology.ontology MPATH:536 precursor T-cell neoplasms Precursor T cell derived neoplasia. Most commonly found in the thymus. mouse_pathology.ontology thymic lymphoma MPATH:537 precursor T-cell lymphoblastic lymphoma/leukaemia Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell carcinoma). mouse_pathology.ontology MPATH:549 carcinoma Developmental and structural abnormalities occurring during embryonic development or during adult life. mouse_pathology.ontology MPATH:55 developmental and structural abnormality A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells. mouse_pathology.ontology MPATH:551 sarcoma Deposition of any homogeneous inorganic material. mouse_pathology.ontology MPATH:555 mineralisation Lesions which in some cases have the potential to become progressively growing malignant tumors. mouse_pathology.ontology MPATH:556 potentially cancerous lesions Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult. mouse_pathology.ontology MPATH:56 developmental or adult structural defect Develop primarily through increasing anaplasia of well differentiated gliomas, mainly astrocytomas or oligodendrogliomas. Typically large and contain cells of different sizes with irrregular nuclei and atypical mitotic figures. (M-9440/3). mouse_pathology.ontology glioblastoma multiforme monstrocytoma MPATH:564 Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. glioblastoma Tumors of neuronal and non-neuronal cells derived from embryonic neurepithelium. mouse_pathology.ontology MPATH:565 tumors of neurepithelial tissue tumors of the meninges mouse_pathology.ontology MPATH:566 tumors of the meninges Tumors of the peripheral nervous system. mouse_pathology.ontology MPATH:570 peripheral nervous system tumors Tumor composed of the epithelial components of the most proximal (trichogenic) portion of the hair follicle associated with an aberrent hair cortex type of cornification (ghost cells or shadow cells). The most primitive cellular component consists of basophilic cells having scanty cytoplasm and nuclei that occasionally overlap to some extent. In humans mineralisation is common. mouse_pathology.ontology MPATH:571 pilomatricoma Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests. mouse_pathology.ontology MPATH:574 nephroblastomatosis This is a new diagnostic term that the MMHC pathology panel felt best described a diagnostically challenging set of tumors that share the feature of being compose of basaloid cells showing follicular differentiation to some extent. These tumors are common in GEM involving the hedgehog signaling pathway and frequently have more than one of the histologic patterns listed below. The designation of benign and malignant has been excluded from the primary diagnosis purposely, as this is frequently difficult to determine in these characteristically well circumscribed tumors. The presence of a disorganized (non-palisaded) sheet-like growth pattern, tumor necrosis, or numerous mitoses are felt to represent malignant transformation. mouse_pathology.ontology MPATH:575 basaloid follicular neoplasms Basaloid neoplasm with numerous mature hair follicles and hair formation. mouse_pathology.ontology MPATH:576 trichofolliculoma Loss of epithelium and the basement membrane (full thickness). Cf Erosion. mouse_pathology.ontology MPATH:579 ulcer The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion. mouse_pathology.ontology MPATH:596 pathological process Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology. mouse_pathology.ontology MPATH:597 cell and tissue damage process developmental process abnormalities mouse_pathology.ontology MPATH:599 developmental process abnormalities An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation. mouse_pathology.ontology MPATH:602 hyperplastic tissue Anatomically located instance of pathological response or entity. mouse_pathology.ontology MPATH:603 pathological anatomical entity Abnormal increase or decrease in the rate of cell growth or cell division including associated changes in the differentiation state of adult cells. mouse_pathology.ontology MPATH:604 Excludes abnormalities of developmental proliferation and differentiation. defective growth and differentiation process A tissue or group of cells in which there has been abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. mouse_pathology.ontology MPATH:605 Nearly exclusively used in an adult context. metaplastic tissue Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage. mouse_pathology.ontology MPATH:607 healing and repair structure A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation. mouse_pathology.ontology MPATH:608 Generally occur following damage or infection with subsequent inflammatory response. Result of the body`s defensive reaction to foreign material. abscess A disease of the heart muscle or myocardium proper. mouse_pathology.ontology MPATH:615 Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive. cardiomyopathy Formation of an epithelium bounded cavity not associated with neoplasia. mouse_pathology.ontology MPATH:62 cyst Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells. lipidosis mouse_pathology.ontology adipose degeneration fatty change fatty degeneration MPATH:622 Most commonly associated with degenerative change in the liver. steatosis Tearing away or separation of two structures or parts. mouse_pathology.ontology MPATH:625 avulsion Deep cutaneous hemangioma with large dilated vascular spaces that manifests spontaneous involution. mouse_pathology.ontology MPATH:629 cavernous hemangioma Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth. mouse_pathology.ontology MPATH:64 The word dysplasia as commonly used refers to a precursor state to neoplasia. This is not the context used for this MPATH term. developmental dysplasia Increase in the diameter of an orifice or tubular structure beyond its normal dimensions. mouse_pathology.ontology MPATH:66 dilatation George Gkoutos 2011-02-19T04:09:12Z mouse_pathology.ontology MPATH:675 psoriasiform dermatitis A blind ended outpouching through the wall of a tubular organ or bounded cavity. mouse_pathology.ontology MPATH:68 diverticulum George Gkoutos 2011-02-19T05:12:17Z mouse_pathology.ontology MPATH:695 spindle cell sarcoma An abnormal passage between two internal organs or leading from a cavity to the body surface. mouse_pathology.ontology MPATH:70 fistula George Gkoutos 2011-02-20T08:44:41Z mouse_pathology.ontology MPATH:707 angiolipoma Malignant tumor of striated muscle or pluripotential mesenchymal stem cells composed mainly of small round cells, with some partial skeletal muscle differentiation. Paul 2011-06-06T03:24:13Z mouse_pathology.ontology MPATH:709 alveolar rhabdomyosarcoma Malignant mesenchymal tumor that morphologically and phenotypically resembles embryonal skeletal muscle. Paul 2011-06-06T03:31:11Z Myosarcoma mouse_pathology.ontology Rhabdopoietic Sarcoma Sarcoma Botryoides [Soft Tissues] Embryonal Sarcoma Malignant Rhabdomyoma MPATH:710 Includes spindle cell, botryoid, anaplastic. embryonal rhabdomyosarcoma Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine. Paul 2011-06-06T03:39:01Z mouse_pathology.ontology MPATH:718 pre-sacral teratoma Benign stromal tumors of the soft tissue with skeletal muscle differentiation. Paul 2011-06-06T03:59:49Z mouse_pathology.ontology MPATH:722 Adult and fetal types. rhabdomyoma Systemic manifestation of MPATH: 407. Paul 2011-06-06T04:11:04Z Desmoid Tumor mouse_pathology.ontology Musculoaponeurotic Fibromatosis Aggressive Fibromatosis Plantar Fibromatosis (Ledderhose Disease) MPATH:723 fibromatosis A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477. mouse_pathology.ontology MPATH:74 hamartoma Presence of a hole/channel through a normally imperforate structure often a membrane or septum. mouse_pathology.ontology MPATH:81 perforation Morphological abnormality following trauma or related insult such as infection. Paul 2012-03-24T03:28:03Z mouse_pathology.ontology MPATH:850 post-traumatic structural abnormality acquired dysmorphology of the external pinna following trauma or infection. Paul 2012-03-24T03:29:48Z mouse_pathology.ontology MPATH:851 auricular deformation Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations. mouse_pathology.ontology MPATH:86 organ specific developmental defect Abnormal development of the heart or vascular tissue resulting in morphological abnormality. mouse_pathology.ontology MPATH:89 cardiovascular developmental defect Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber. mouse_pathology.ontology MPATH:90 aneurysm Follows the presence of a hematoma in the wall of an artery Splitting of the media occurs, blood enters the split through a tear in the intima. mouse_pathology.ontology MPATH:97 dissecting aneurysm A stretching and widening of the lymphatic vessels. mouse_pathology.ontology Lymphectasia telangiectasia lymphatica MPATH:98 lymphangiectasis An anaplastic astrocytoma (grade III astrocytic tumor) or glioblastoma (grade IV astrocytic tumor). High Grade Astrocytic Neoplasm High Grade Astrocytic Tumor High-Grade Astrocytic Neoplasm High-Grade Astrocytic Tumor mouse_pathology.ontology NCIT:C102897 High Grade Astrocytic Tumor A primary or metastatic malignant neoplasm involving the cardiovascular system. Malignant Cardiovascular Neoplasm mouse_pathology.ontology NCIT:C114940 Malignant Cardiovascular Neoplasm A term that refers to germinoma, seminoma, or dysgerminoma. Germinomatous Germ Cell Tumor mouse_pathology.ontology NCIT:C121618 Germinomatous Germ Cell Tumor A term that refers to teratoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, or mixed forms of these tumors. Nongerminomatous Germ Cell Tumor Nongerminomatous Germ Cell Tumor Including Central Nervous System mouse_pathology.ontology NCIT:C121619 Nongerminomatous Germ Cell Tumor A malignant epithelial neoplasm characterized by the presence of spindle cells and anaplastic morphologic features. Giant cells and a sarcomatous component may also be present. CARCINOMA, SPINDLE CELL, MALIGNANT Pseudosarcomatous Carcinoma Sarcomatoid Carcinoma Spindle Cell Carcinoma sarcomatoid carcinoma mouse_pathology.ontology NCIT:C27004 Sarcomatoid Carcinoma A malignant mesenchymal neoplasm composed of spindle-shaped cells. This is a morphologic term which can be applied to a wide range of sarcomas. Spindle Cell Sarcoma spindle cell sarcoma mouse_pathology.ontology NCIT:C27005 Spindle Cell Sarcoma A neoplasm arising from hematopoietic cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic system). Hematopoietic cell neoplasms can also involve other anatomic sites (e.g. central nervous system, gastrointestinal tract), either by metastasis, direct tumor infiltration, or neoplastic transformation of extranodal lymphoid tissues. The commonest forms are the various types of leukemia, Hodgkin and non-Hodgkin lymphomas, myeloproliferative neoplasms, and myelodysplastic syndromes. Hematologic Cancer Hematologic Malignancy Hematologic Neoplasm Hematological Neoplasm Hematological Tumor Hematopoietic Cancer Hematopoietic Cell Tumor Hematopoietic Neoplasm Hematopoietic Neoplasms including Lymphomas Hematopoietic Tumor Hematopoietic and Lymphoid Cell Neoplasm Hematopoietic and Lymphoid Neoplasms Hematopoietic malignancy, NOS Hematopoietic, Including Myeloma Malignant Hematologic Neoplasm Malignant Hematopoietic Neoplasm hematologic cancer mouse_pathology.ontology NCIT:C27134 Hematopoietic and Lymphoid Cell Neoplasm An aggressive malignant neoplasm with a poor response to therapy, usually presenting as stage III/IV disease. It is characterized by the presence of neoplastic cells with morphologic and immunophenotypic characteristics similar to those seen in mature histiocytes. Histiocytic Sarcoma SARCOMA, HISTIOCYTIC, MALIGNANT mouse_pathology.ontology NCIT:C27349 Histiocytic Sarcoma A benign or malignant neoplasm of the liver parenchyma and intrahepatic bile ducts that occurs during childhood. Childhood Hepatic Neoplasm Childhood Liver Neoplasm Childhood Liver and Intrahepatic Bile Duct Neoplasm mouse_pathology.ontology NCIT:C27368 Childhood Liver and Intrahepatic Bile Duct Neoplasm An adenocarcinoma arising from the follicular cells of the thyroid gland. According to the degree of differentiation, it is classified either as differentiated carcinoma (extensive evidence of follicular cell differentiation), or poorly differentiated carcinoma (limited evidence of follicular cell differentiation). Thyroid Adenocarcinoma Thyroid Gland Adenocarcinoma mouse_pathology.ontology NCIT:C27380 Thyroid Gland Adenocarcinoma A neoplasm that arises from the hair follicle and does not metastasize to other anatomic sites. Benign Follicular Neoplasm Benign Follicular Tumor Benign Hair Follicle Neoplasm Benign Hair Follicle Tumor HAIR FOLLICLE NEOPLASM, BENIGN mouse_pathology.ontology NCIT:C27520 Benign Hair Follicle Neoplasm An adenocarcinoma that arises from the intrahepatic bile ducts, the hepatic ducts, or the extrahepatic bile ducts. Adenocarcinomas that arise from the intrahepatic bile ducts or the hepatic ducts are called cholangiocarcinomas. Bile Duct Adenocarcinoma mouse_pathology.ontology NCIT:C27813 Bile Duct Adenocarcinoma A malignant tumor arising from the epithelium of the intrahepatic or extrahepatic bile duct. Carcinomas that arise from the intrahepatic bile ducts and the hepatic ducts are called cholangiocarcinomas and are almost always adenocarcinomas. Carcinomas that arise from the extrahepatic bile ducts are adenocarcinomas, adenosquamous carcinomas, squamous cell carcinomas, small cell carcinomas, or mucoepidermoid carcinomas. Bile Duct Cancer Bile Duct Carcinoma bile duct cancer mouse_pathology.ontology NCIT:C27814 Bile Duct Carcinoma B-Cell Lymphocytic Neoplasm B-Cell Neoplasm mouse_pathology.ontology NCIT:C27907 B-Cell Neoplasm T-Cell Neoplasm T-Cell and NK-Cell Neoplasm mouse_pathology.ontology NCIT:C27908 T-Cell and NK-Cell Neoplasm A neoplasm that arises from mature B-lymphocytes or plasma cells. Representative examples include mature B-cell non-Hodgkin lymphomas, chronic lymphocytic leukemia, hairy cell leukemia, and plasma cell neoplasms. Mature B-Cell Lymphocytic Neoplasm Mature B-Cell Neoplasm mouse_pathology.ontology NCIT:C27910 Mature B-Cell Neoplasm A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. ADENOCARCINOMA, MALIGNANT Adenocarcinoma Adenocarcinoma, NOS adenocarcinoma mouse_pathology.ontology NCIT:C2852 Adenocarcinoma A morphologic variant of adenocarcinoma. It is characterized by the presence of a papillary growth pattern. Representative examples include thyroid gland papillary carcinoma, invasive papillary breast carcinoma, and ovarian serous surface papillary adenocarcinoma. ADENOCARCINOMA, PAPILLARY, MALIGNANT Papillary Adenocarcinoma mouse_pathology.ontology NCIT:C2853 Papillary Adenocarcinoma A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract. ADENOMA, BENIGN Adenoma adenoma mouse_pathology.ontology NCIT:C2855 Adenoma A benign or malignant (primary or metastatic) neoplasm affecting the adrenal glands. Adrenal Gland Neoplasm Adrenal Gland Tumor Adrenal Neoplasm Adrenal Neoplasms Adrenal Tumor Neoplasm of Adrenal Gland Neoplasm of the Adrenal Gland Tumor of Adrenal Gland Tumor of the Adrenal Gland mouse_pathology.ontology NCIT:C2859 Adrenal Gland Neoplasm Abnormal growth of the cells that comprise the tissues of the skin, without any evidence of malignancy. Benign Cutaneous Neoplasm Benign Cutaneous Tumor Benign Neoplasm of Skin Benign Neoplasm of the Skin Benign Skin Neoplasm Benign Skin Tumor Benign Tumor of Skin Benign Tumor of the Skin Skin Neoplasms, Benign mouse_pathology.ontology NCIT:C2896 Benign Skin Neoplasm A benign or malignant neoplasm that affects the intrahepatic or extrahepatic bile ducts. Representative examples of benign neoplasms include bile duct adenoma and extrahepatic bile duct lipoma. Representative examples of malignant neoplasms include intrahepatic and extrahepatic cholangiocarcinoma. Bile Duct Neoplasm Bile Duct Tumor Intrahepatic and Extrahepatic Bile Duct Neoplasm Intrahepatic and Extrahepatic Bile Duct Tumor mouse_pathology.ontology NCIT:C2898 Bile Duct Neoplasm A benign or malignant neoplasm that arises from or metastasizes to the brain. Brain Neoplasm Brain Neoplasms Brain Tumor Brain tumor Neoplasm of Brain Neoplasm of the Brain Tumor of Brain Tumor of the Brain brain tumor mouse_pathology.ontology NCIT:C2907 Brain Neoplasm A benign or malignant neoplasm of the breast parenchyma. It can originate from the ducts, lobules or the breast adipose tissue. Breast neoplasms are much more common in females than males. Breast Neoplasm Breast Tumor Neoplasm of Breast Neoplasm of the Breast Neoplasm, Breast Tumor of Breast Tumor of the Breast mouse_pathology.ontology NCIT:C2910 Breast Neoplasm A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas. CARCINOMA, MALIGNANT Carcinoma Carcinoma, NOS Epithelial Carcinoma Epithelioma Malignant Malignant Epithelial Neoplasm Malignant Epithelial Tumor Malignant Epithelioma carcinoma epithelial carcinoma mouse_pathology.ontology NCIT:C2916 Carcinoma A primary or metastatic tumor involving the skin. Primary malignant skin tumors most often are carcinomas (either basal cell or squamous cell carcinomas that arise from cells in the epidermis) or melanomas that arise from pigment-containing skin melanocytes. Metastatic tumors to the skin include carcinomas and lymphomas. Malignant Neoplasm of Skin Malignant Neoplasm of the Skin Malignant Skin Neoplasm Malignant Skin Tumor Malignant Tumor of Skin Malignant Tumor of the Skin Melanoma and Non-Melanoma Skin Cancer Skin Cancer Skin Cancer, Including Melanoma Skin Neoplasm, Malignant Skin cancer, NOS skin cancer mouse_pathology.ontology NCIT:C2920 Malignant Skin Neoplasm The most frequently seen skin cancer. It arises from basal cells of the epidermis and pilosebaceous units. Clinically it is divided into the following types: nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing or morphea-like. More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck and the remaining 15% on the trunk and extremities. Basal cell carcinoma usually grows in a slow and indolent fashion. However, if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and bone. Distant metastases are rare. Excision, curettage and irradiation cure most basal cell carcinomas. BCC Basal Cell Cancer Basal Cell Carcinoma Basal Cell Carcinoma of Skin Basal Cell Carcinoma of the Skin Basal Cell Epithelioma Basal Cell Skin Carcinoma Basal cell carcinoma Skin Basal Cell Carcinoma basal cell cancer basal cell carcinoma mouse_pathology.ontology NCIT:C2921 Skin Basal Cell Carcinoma A group of at least three distinct histological types of lung cancer, including squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy. NSCLC NSCLC - Non-Small Cell Lung Cancer Non Small Cell Lung Cancer NOS Non-Small Cell Cancer of Lung Non-Small Cell Cancer of the Lung Non-Small Cell Carcinoma of Lung Non-Small Cell Carcinoma of the Lung Non-Small Cell Lung Cancer Non-Small Cell Lung Carcinoma Non-small cell lung cancer, NOS non-small cell lung cancer mouse_pathology.ontology NCIT:C2926 Non-Small Cell Lung Carcinoma A malignant epithelial neoplasm characterized by a papillary growth pattern. A papillary carcinoma may be composed of glandular cells (papillary adenocarcinoma), squamous cells (papillary squamous cell carcinoma), or transitional cells (papillary transitional cell carcinoma). Bladder carcinoma is a representative example of papillary transitional cell carcinoma. Papillary Carcinoma mouse_pathology.ontology NCIT:C2927 Papillary Carcinoma A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma. CARCINOMA, SQUAMOUS CELL, MALIGNANT Epidermoid Carcinoma Epidermoid Cell Cancer Malignant Epidermoid Cell Neoplasm Malignant Epidermoid Cell Tumor Malignant Squamous Cell Neoplasm Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Cancer Squamous Cell Carcinoma Squamous Cell Epithelioma epidermoid carcinoma squamous cell carcinoma mouse_pathology.ontology NCIT:C2929 Squamous Cell Carcinoma A malignant neoplasm arising from the transitional epithelium, usually affecting the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary configuration. It is graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural patterns. Grade 1 transitional cell carcinoma is histologically benign but it may recur. Transitional cell carcinomas may also affect the upper respiratory tract and the ovaries. CARCINOMA, UROTHELIAL, MALIGNANT Transitional Carcinoma Transitional Cell Carcinoma transitional cell carcinoma mouse_pathology.ontology NCIT:C2930 Transitional Cell Carcinoma A benign or malignant (primary or metastatic) tumor involving the cerebellum. -- 2003 Cerebellar Neoplasm Cerebellar Tumor Neoplasm of Cerebellum Neoplasm of the Cerebellum Tumor of Cerebellum Tumor of the Cerebellum mouse_pathology.ontology NCIT:C2935 Cerebellar Neoplasm A neoplasm that involves a brain ventricle. It may be a primary neoplasm arising from a brain ventricle, a metastasis from a distant anatomic site, or an extension of an invasive neoplasm from an adjacent brain structure. Brain Neoplasms, Intraventricular Intraventricular Brain Neoplasm Intraventricular Brain Neoplasms Intraventricular Brain Tumor Intraventricular Neoplasm of Brain Intraventricular Neoplasm of the Brain Intraventricular Neoplasms Intraventricular Tumor of Brain Intraventricular Tumor of the Brain mouse_pathology.ontology NCIT:C2937 Intraventricular Brain Neoplasm A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from the bone and soft tissue. It usually affects middle-aged to elderly adults. The pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion. CHONDROSARCOMA, MALIGNANT Chondrosarcoma chondrosarcoma mouse_pathology.ontology NCIT:C2946 Chondrosarcoma A malignant bone tumor arising from the remnants of the fetal notochord. Although it can occur at all ages, it is more frequently seen in middle-aged adults. The most frequent sites of involvement are the sacrococcygeal area, spheno-occipital area, and cervico-thoraco-lumbar spine. Microscopically, chordomas are composed of cells that form cords and lobules, separated by mucoid intercellular tissue. Some of the cells are large (physaliphorous) and have vacuolated cytoplasm and prominent vesicular nuclei. Other tumor cells are small with small nuclei without visible nucleoli. Chordomas tend to recur and may metastasize. The most common sites of metastasis are the skin and bone. CHORDOMA, MALIGNANT Chordoma chordoma mouse_pathology.ontology NCIT:C2947 Chordoma A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms. Colorectal Neoplasm Colorectal Tumor Large Bowel Neoplasm Large Bowel Tumor Large Intestinal Neoplasm Large Intestine Neoplasm Large Intestine Tumor Neoplasm of Large Bowel Neoplasm of the Large Bowel Tumor of Large Bowel Tumor of the Large Bowel mouse_pathology.ontology NCIT:C2956 Colorectal Neoplasm A benign or borderline cystic epithelial neoplasm arising from the glandular epithelium. The epithelial cells line the cystic spaces which contain serous or mucinous fluid. Representative examples include ovarian and pancreatic cystadenomas. CYSTADENOMA, BENIGN Cystadenoma Cystoma mouse_pathology.ontology NCIT:C2972 Cystadenoma A serous or mucinous benign or low malignant potential cystic epithelial neoplasm. It is characterized by the presence of glandular epithelial cells forming papillary structures. CYSTADENOMA, PAPILLARY, BENIGN Papillary Cystadenoma mouse_pathology.ontology NCIT:C2974 Papillary Cystadenoma A malignant germ cell tumor characterized by the presence of a monotonous primitive germ cell population. The neoplastic cells form aggregates and have an abundant pale cytoplasm and uniform nuclei. The aggregates of the germ cells are separated by fibrous septa which contain inflammatory cells, mostly T-lymphocytes. It arises primarily in the ovaries, but can occur both primarily and secondarily at other sites, particularly the central nervous system. It responds to chemotherapy and radiotherapy. Its prognosis is related to the tumor stage. DYSGERMINOMA, MALIGNANT Dysgerminoma dysgerminoma mouse_pathology.ontology NCIT:C2996 Dysgerminoma A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. Representative examples include pituitary gland adenoma, pituitary gland carcinoma, thyroid gland carcinoma, carcinoid tumor, and neuroendocrine carcinoma. Endocrine Neoplasm Endocrine System Neoplasm Endocrine System Tumor Endocrine Tumor mouse_pathology.ontology NCIT:C3010 Endocrine Neoplasm A WHO grade II, slow growing tumor of children and young adults, usually located intraventricularly. It is the most common ependymal neoplasm. It often causes clinical symptoms by blocking cerebrospinal fluid pathways. Key histological features include perivascular pseudorosettes and ependymal rosettes. (WHO) Ependymoma Ependymoma, NOS WHO Grade II Ependymal Neoplasm WHO Grade II Ependymal Tumor ependymoma mouse_pathology.ontology NCIT:C3017 Ependymoma A benign or malignant neoplasm affecting the structures of the eye. Eye Neoplasm Eye Tumor Neoplasm of Eye Neoplasm of the Eye Ocular Neoplasm Ocular Tumor Tumor of Eye Tumor of the Eye mouse_pathology.ontology NCIT:C3030 Eye Neoplasm A non-metastasizing neoplasm arising from the fibrous tissue. It is characterized by the presence of spindle-shaped fibroblasts. FIBROMA, BENIGN Fibroma mouse_pathology.ontology NCIT:C3041 Fibroma A poorly circumscribed neoplasm arising from the soft tissues. It is characterized by the presence of spindle-shaped fibroblasts and an infiltrative growth pattern. Fibromatosis fibromatosis mouse_pathology.ontology NCIT:C3042 Fibromatosis A malignant mesenchymal fibroblastic neoplasm affecting the soft tissue and bone. FIBROSARCOMA, MALIGNANT Fibrosarcoma Fibrosarcoma (excluding infantile fibrosarcoma) Fibrosarcoma - not infantile Malignant Fibromatous Neoplasm fibrosarcoma mouse_pathology.ontology NCIT:C3043 Fibrosarcoma A benign neuroblastic tumor of the sympathetic nervous system that occurs in childhood. Ganglioneuroma typically arises from the sympathetic trunk in the mediastinum. Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. Common presenting features include a palpable abdominal mass, hepatomegaly, and a thoracic mass detected on routine chest X-ray. GANGLIONEUROMA, BENIGN Ganglioneuroma Ganglioneuroma (Schwannian Stroma-Dominant) Neural Crest Tumor, Benign mouse_pathology.ontology NCIT:C3049 Ganglioneuroma A benign or malignant neoplasm involving any part of the digestive system. Digestive Neoplasm Digestive System Neoplasm Digestive System Tumor Digestive Tumor GI Neoplasm GI System Neoplasm GI System Tumor GI Tumor Gastrointestinal Neoplasm Gastrointestinal System Neoplasm Gastrointestinal System Tumor Gastrointestinal Tumor Neoplasm of Digestive System Neoplasm of GI System Neoplasm of Gastrointestinal System Neoplasm of the Digestive System Neoplasm of the GI System Neoplasm of the Gastrointestinal System Tumor of Digestive System Tumor of GI System Tumor of Gastrointestinal System Tumor of the Digestive System Tumor of the GI System Tumor of the Gastrointestinal System mouse_pathology.ontology NCIT:C3052 Digestive System Neoplasm The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma). (WHO) GBM GBM (Glioblastoma) Glioblastoma Glioblastoma Multiforme Glioblastoma multiforme Grade IV Astrocytic Neoplasm Grade IV Astrocytic Tumor Spongioblastoma Multiforme glioblastoma glioblastoma multiforme grade IV astrocytoma mouse_pathology.ontology NCIT:C3058 Glioblastoma A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas. Glial Neoplasm Glial Tumor Glioma Neoplasm of Neuroglia Neoplasm of the Neuroglia Neuroglial Neoplasm Neuroglial Tumor Tumor of Neuroglia Tumor of the Neuroglia glial tumor glioma mouse_pathology.ontology NCIT:C3059 Glioma A benign or malignant neoplasm that affects the anatomic structures of the head and neck region. Representative examples of benign neoplasms include salivary gland pleomorphic adenoma and nasal cavity papilloma. Representative examples of malignant neoplasms include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. Head and Neck Neoplasm Head and Neck Neoplasm (Excluding Central Nervous System) Head and Neck Tumor Neoplasm of Head and Neck Neoplasm of the Head and Neck Tumor of Head and Neck Tumor of the Head and Neck mouse_pathology.ontology NCIT:C3077 Head and Neck Neoplasm A benign vascular lesion characterized by the formation of capillary-sized or cavernous vascular channels. Angioma Benign Angioma Benign Hemangioma HEMANGIOMA, BENIGN Hemangioma mouse_pathology.ontology NCIT:C3085 Hemangioma A hemangioma characterized by the presence of cavernous vascular spaces. Cavernoma Cavernous Angioma Cavernous Hemangioma mouse_pathology.ontology NCIT:C3086 Cavernous Hemangioma A malignant tumor arising from the endothelial cells of the blood vessels. Microscopically, it is characterized by frequently open vascular anastomosing and branching channels. The malignant cells that line the vascular channels are spindle or epithelioid and often display hyperchromatic nuclei. Angiosarcomas most frequently occur in the skin and breast. Patients with long-standing lymphedema are at increased risk of developing angiosarcoma. Angiosarcoma HEMANGIOSARCOMA, MALIGNANT Hemangiosarcoma Malignant Angioendothelioma Malignant Hemangioendothelioma angiosarcoma hemangiosarcoma mouse_pathology.ontology NCIT:C3088 Angiosarcoma A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. CARCINOMA, HEPATOCELLULAR, MALIGNANT Carcinoma of Liver Cells Carcinoma of the Liver Cells HCC Hepatocellular Carcinoma Hepatocellular carcinoma Hepatoma Liver Cell Cancer (Hepatocellular Carcinoma) Liver Cell Carcinoma Primary Carcinoma of Liver Cells Primary Carcinoma of the Liver Cells hepatocellular carcinoma hepatoma mouse_pathology.ontology NCIT:C3099 Hepatocellular Carcinoma A benign or malignant neoplasm that occurs in brain parenchymal tissue below the tentorium cerebelli. Brain Neoplasms, Infratentorial Infratentorial Neoplasm Infratentorial Neoplasms Infratentorial Tumor Infratentorial Tumors Neoplasms, Infratentorial mouse_pathology.ontology NCIT:C3139 Infratentorial Neoplasm A benign or malignant neoplasm involving the small or large intestine. Intestinal Neoplasm Intestinal Neoplasms Intestinal Tumor Intestinal Tumors Neoplasm of Intestines Neoplasm of the Intestines Tumor of Intestines Tumor of the Intestines mouse_pathology.ontology NCIT:C3141 Intestinal Neoplasm A benign or malignant neoplasm affecting the kidney. Representative examples of benign renal neoplasms include fibroma, lipoma, oncocytoma, and juxtaglomerular cell tumor. Representative examples of malignant renal neoplasms include renal cell carcinoma, renal pelvis carcinoma, Wilms tumor, rhabdoid tumor, sarcoma, and lymphoma. Kidney Neoplasm Kidney Tumor Neoplasm of Kidney Neoplasm of the Kidney Renal Neoplasm Renal Tumor Renal Tumors Tumor of Kidney Tumor of the Kidney mouse_pathology.ontology NCIT:C3150 Kidney Neoplasm A well-circumscribed benign smooth muscle neoplasm characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. Fibroid Fibroid Neoplasm Fibroid Tumor LEIOMYOMA, BENIGN Leiomyoma Leiomyomatous Neoplasm Leiomyomatous Tumor fibroid leiomyoma mouse_pathology.ontology NCIT:C3157 Leiomyoma An uncommon, aggressive malignant smooth muscle neoplasm, usually occurring in post-menopausal women. It is characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid, granular cell, inflammatory and myxoid leimyosarcomas. LEIOMYOSARCOMA, MALIGNANT Leiomyosarcoma Leiomyosarcoma (excluding uterine leiomyosarcoma) Leiomyosarcoma - not uterine Leiomyosarcomas leiomyosarcoma mouse_pathology.ontology NCIT:C3158 Leiomyosarcoma A sex cord-stromal tumor occurring in the testis and rarely in the ovary. It is predominantly or completely composed of Leydig cells which may contain crystals of Reinke. In males it usually presents as a painless testicular enlargement and it may be associated with gynecomastia and decreased libido. The majority of the cases have a benign clinical course. Approximately 10% of the cases have a malignant clinical course and metastasize. In females it may be associated with androgenic manifestations and it follows a benign clinical course. Interstitial Cell Neoplasm Interstitial Cell Tumor Leydig Cell Neoplasm Leydig Cell Tumor mouse_pathology.ontology NCIT:C3188 Leydig Cell Tumor A benign, usually painless, well-circumscribed lipomatous tumor composed of adipose tissue. LIPOMA, BENIGN Lipoma lipoma mouse_pathology.ontology NCIT:C3192 Lipoma A benign or malignant, primary or metastatic neoplasm involving the lungs. Representative examples of benign neoplasms include adenoma, papilloma, chondroma, and endobronchial lipoma. Representative examples of malignant neoplasms include carcinoma, carcinoid tumor, sarcoma, and lymphoma. Lung Neoplasm Lung Neoplasms Lung Tumor Neoplasm of Lung Neoplasm of the Lung Tumor of Lung Tumor of the Lung mouse_pathology.ontology NCIT:C3200 Lung Neoplasm A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas. LYMPHOMA, MALIGNANT Lymphoma Lymphoma (Hodgkin and Non-Hodgkin) Lymphoma (Hodgkin's and Non-Hodgkin's) Lymphoma, NOS Lymphomatous Malignant Lymphoma lymphoma mouse_pathology.ontology NCIT:C3208 Lymphoma Abnormal growth of cells comprising the retina with malignant characteristics. Malignant Neoplasm of Retina Malignant Neoplasm of the Retina Malignant Retina Neoplasm Malignant Retina Tumor Malignant Retinal Neoplasm Malignant Retinal Tumor Malignant Tumor of Retina Malignant Tumor of the Retina mouse_pathology.ontology NCIT:C3216 Malignant Retinal Neoplasm A benign or malignant neoplasm that affects the structures of the mediastinum. Representative examples include mediastinal lipoma, mediastinal schwannoma, thymoma, and mediastinal lymphoma. Mediastinal Neoplasm Mediastinal Neoplasm NOS Mediastinal Tumor Neoplasm of Mediastinum Neoplasm of the Mediastinum Tumor of Mediastinum Tumor of the Mediastinum mouse_pathology.ontology NCIT:C3221 Mediastinal Neoplasm A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, large cell medulloblastoma, and medulloblastoma with extensive nodularity. MEDULLOBLASTOMA, MALIGNANT Medulloblastoma Medulloblastomas medulloblastoma mouse_pathology.ontology NCIT:C3222 Medulloblastoma A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain. MELANOMA, MALIGNANT Malignant Melanoma Melanoma melanoma mouse_pathology.ontology NCIT:C3224 Melanoma A benign or malignant neoplasm that affects the meninges. The majority of the neoplasms arise from meningothelial cells and are called meningiomas. Non-meningothelial cell neoplasms include mesenchymal, non-meningothelial tumors, hemangiopericytomas, and melanocytic lesions. Meningeal Neoplasm Meningeal Neoplasms Meningeal Tumor Meninges Neoplasm Meninges Tumor Neoplasm of Meninges Neoplasm of the Meninges Tumor of Meninges Tumor of the Meninges mouse_pathology.ontology NCIT:C3229 Meningeal Neoplasm A generally slow growing tumor attached to the dura mater. It is composed of neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, often women and it has a wide range of histopathological appearances. Of the various subtypes, meningothelial, fibrous and transitional meningiomas are the most common. Most meningiomas are WHO grade I tumors, and some are WHO grade II or III tumors. Most subtypes share a common clinical behavior, although some subtypes are more likely to recur and follow a more aggressive clinical course. (Adapted from WHO) Meningioma Meningioma, NOS meningioma mouse_pathology.ontology NCIT:C3230 Meningioma A usually malignant and aggressive neoplasm of the mesothelium which is often associated with exposure to asbestos. Mesothelioma mesothelioma mouse_pathology.ontology NCIT:C3234 Mesothelioma A benign or malignant neoplasm that affects the neck region. Neck Neoplasm Neck Neoplasms (Including All Pharyngeal Related Neoplasms) Neck Tumor Neoplasm of Neck Neoplasm of the Neck Tumor of Neck Tumor of the Neck mouse_pathology.ontology NCIT:C3260 Neck Neoplasm A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias. Neoplasia Neoplasm Neoplastic Disease Neoplastic Growth neoplasia neoplasm tumor mouse_pathology.ontology NCIT:C3262 Neoplasm A term that refers to the classification of a neoplastic process according to the anatomic site that is involved. Neoplasm by Site mouse_pathology.ontology NCIT:C3263 Neoplasm by Site A usually malignant neoplasm composed of primitive (immature) tissues that resemble fetal tissues. Medulloblastoma, Ependymoblastoma, Pineoblastoma, and Wilms tumor are representative embryonal neoplasms. --2003 Embryonal Neoplasm embryonal tumor mouse_pathology.ontology NCIT:C3264 Embryonal Neoplasm An embryonal neoplasm characterized by the presence of epithelial, mesenchymal, and blastema components. The vast majority of cases arise from the kidney. A small number of cases with morphologic features resembling Wilms tumor of the kidney have been reported arising from the ovary and the cervix. Wilms Tumor Wilms tumor Wilms tumor (Nephroblastoma) Wilms' Tumor mouse_pathology.ontology NCIT:C3267 Wilms Tumor A benign or malignant, primary or metastatic neoplasm involving the central or peripheral nervous system. Neoplasm of Nervous System Neoplasm of the Nervous System Nervous System Neoplasm Nervous System Neoplasms Nervous System Tumor Nervous System Tumour Tumor of Nervous System Tumor of the Nervous System mouse_pathology.ontology NCIT:C3268 Nervous System Neoplasm A benign, usually encapsulated slow growing tumor composed of Schwann cells. It affects peripheral and cranial nerves. It recurs infrequently and only rare cases associated with malignant transformation have been reported. Benign Neurilemmoma Benign Schwannoma Neurilemmoma Neurinoma SCHWANNOMA, BENIGN Schwannoma Schwannoma (WHO Grade I) Schwannoma (Who Grade I) schwannoma mouse_pathology.ontology NCIT:C3269 Schwannoma A neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation. NEUROBLASTOMA, MALIGNANT Neural Crest Tumor, Malignant Neuroblastoma Neuroblastoma (Schwannian Stroma-Poor) Neuroblastoma (Schwannian Stroma-poor) neuroblastoma mouse_pathology.ontology NCIT:C3270 Neuroblastoma An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple masses. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors. NEUROFIBROMA, BENIGN Neurofibroma Neurofibroma (WHO Grade I) neurofibroma mouse_pathology.ontology NCIT:C3272 Neurofibroma A benign or malignant neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial skeleton or the gingiva. Benign tumors are slow growing and are not associated with specific clinical symptoms. Pain is absent or slight. Malignant tumors are usually associated with rapid swelling and pain. Odontogenic Neoplasm Odontogenic Tumor mouse_pathology.ontology NCIT:C3286 Odontogenic Neoplasm A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). (Adapted from WHO) Oligodendroglioma Oligodendroglioma, NOS WHO Grade II Oligodendroglial Neoplasm WHO Grade II Oligodendroglial Tumor Well Differentiated Oligodendroglial Tumor Well Differentiated Oligodendroglioma oligodendroglioma mouse_pathology.ontology NCIT:C3288 Oligodendroglioma A benign, well-circumscribed, bone-forming neoplasm predominantly composed of lamellar bone. It usually arises from the calvarial, facial, or jaw bones. It is usually asymptomatic but it may cause local swelling or obstruction of the paranasal sinuses. Asymptomatic cases have an indolent clinical course. OSTEOMA, BENIGN Osteoma mouse_pathology.ontology NCIT:C3296 Osteoma A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves. Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia. Tumors arising from the adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern. There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas. The only definitive indicator of malignancy is the presence of regional or distant metastases. Neoplasm of Paraganglion Neoplasm of the Paraganglion Paraganglioma Paraganglion Neoplasm Paraganglion Tumor Paraganglionic Neoplasm Paraganglionic Tumor Tumor of Paraganglion Tumor of the Paraganglion paraganglioma mouse_pathology.ontology NCIT:C3308 Paraganglioma A benign or malignant neoplasm arising from a peripheral nerve or the perineural sheaths. CNS-excluded nervous sys. cancer CNS-excluded nervous system cancer, NOS Neoplasm of PNS Neoplasm of Peripheral Nerve Neoplasm of Peripheral Nervous System Neoplasm of the PNS Neoplasm of the Peripheral Nerve Neoplasm of the Peripheral Nervous System Neoplasms, PNS Neoplasms, Peripheral Nervous System PNS Neoplasm PNS Neoplasms PNS Tumor Peripheral Nerve Neoplasm Peripheral Nerve Tumor Peripheral Nervous System Neoplasm Peripheral Nervous System Tumor Tumor of PNS Tumor of Peripheral Nerve Tumor of Peripheral Nervous System Tumor of the PNS Tumor of the Peripheral Nerve Tumor of the Peripheral Nervous System mouse_pathology.ontology NCIT:C3321 Peripheral Nervous System Neoplasm A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present. Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Adrenal Medullary Paraganglioma Adrenal Medullary Pheochromocytoma Adrenal Pheochromocytoma Chromaffin Paraganglioma of the Adrenal Gland Intraadrenal Paraganglioma PCC Pheochromocytoma Pheochromocytoma (adrenal) pheochromocytoma mouse_pathology.ontology NCIT:C3326 Adrenal Gland Pheochromocytoma Neoplasms that are located in the pineal gland. These neoplasms arise either from pineal parenchymal cells (pineocytes), as do pineocytomas and the more aggressive pineoblastomas, or from other cell types, as do pineal astrocytic tumors (notably pilocytic astrocytomas) and germ cell tumors. Clinical symptoms include neuro-ophthalmologic dysfunction, changes in mental status, dysfunction of the brain stem, and hypothalamic-based endocrine abnormalities. Neoplasm of Pineal Area Neoplasm of Pineal Region Neoplasm of the Pineal Area Neoplasm of the Pineal Region Pineal Area Neoplasm Pineal Area Tumor Pineal Body Neoplasm Pineal Body Tumor Pineal Neoplasm Pineal Region Neoplasm Pineal Region Tumor Pineal Tumor Pinealoma Tumor of Pineal Area Tumor of Pineal Region Tumor of the Pineal Area Tumor of the Pineal Region pineal region tumor mouse_pathology.ontology NCIT:C3328 Pineal Region Neoplasm An autosomal dominant disorder, characterized by the presence of multiple adenomas in the colon and rectum. It is caused by a germline mutation in the adenomatous polyposis coli (APC) gene which is located on the long arm of chromosome 5. The adenomas are most often tubular, and they have the tendency to progress to adenocarcinoma. They can occur throughout the colon, but they tend to concentrate in the rectum and sigmoid colon. The colorectal adenomas are detected during endoscopic examination between the age of 10 and 20 years. The adenomas increase in size and numbers with age, and there is usually progression of one or more adenomas to adenocarcinoma. The mean age of development of adenocarcinoma is about 40 years. Signs include rectal bleeding and mucousy diarrhea. APC - Adenomatous Polyposis Coli Adenomatous Polyposis Coli FAP Familial Adenomatous Polyposis Familial Adenomatous Polyposis Coli Familial Adenomatous Polyposis Syndrome Hereditary Adenomatous Polyposis Coli Polyposis Coli familial adenomatous polyposis familial polyposis mouse_pathology.ontology NCIT:C3339 Familial Adenomatous Polyposis A benign or malignant, primary or metastatic neoplasm involving the respiratory tract. Neoplasm of Respiratory Tract Neoplasm of the Respiratory Tract Respiratory Tract Neoplasm Respiratory Tract Tumor Tumor of Respiratory Tract Tumor of the Respiratory Tract mouse_pathology.ontology NCIT:C3355 Respiratory Tract Neoplasm A benign or malignant neoplasm that affects the retroperitoneum. Retroperitoneal Neoplasm mouse_pathology.ontology NCIT:C3357 Retroperitoneal Neoplasm A benign mesenchymal tumor arising from skeletal or cardiac muscle. RHABDOMYOMA, BENIGN Rhabdomyoma Rhabdomyomatous Neoplasm mouse_pathology.ontology NCIT:C3358 Rhabdomyoma A rare aggressive malignant mesenchymal neoplasm arising from skeletal muscle. It usually occurs in children and young adults. Only a small percentage of tumors arise in the skeletal muscle of the extremities. The majority arise in other anatomical sites. RHABDOMYOSARCOMA, MALIGNANT Rhabdomyosarcoma Rhabdomyosarcoma, NOS rhabdomyosarcoma mouse_pathology.ontology NCIT:C3359 Rhabdomyosarcoma A benign or malignant tumor involving the skin. Representative examples of benign skin neoplasms include the benign melanocytic skin nevus, acanthoma, sebaceous adenoma, sweat gland adenoma, lipoma, hemangioma, fibroma, and benign fibrous histiocytoma. Representative examples of malignant skin neoplasms include basal cell carcinoma, squamous cell carcinoma, melanoma, and Kaposi sarcoma. Neoplasm of Skin Neoplasm of the Skin Skin Neoplasm Skin Neoplasms Skin Tumor Tumor of Skin Tumor of the Skin mouse_pathology.ontology NCIT:C3372 Skin Neoplasm A benign, intermediate, or malignant neoplasm that arises from the soft tissue. The most common types are lipomatous (fatty), vascular, smooth muscle, fibrous, and fibrohistiocytic neoplasms. Neoplasm of Soft Tissue Neoplasm of the Soft Tissue Soft Tissue Neoplasm Soft Tissue Tumor Soft Tissue Tumors Soft tissue neoplasm, NOS Tumor of Soft Tissue Tumor of the Soft Tissue mouse_pathology.ontology NCIT:C3377 Soft Tissue Neoplasm A benign or malignant neoplasm that occurs within the intracranial cavity above the tentorium cerebelli. Brain Neoplasms, Supratentorial Supratentorial Neoplasm Supratentorial Neoplasms Supratentorial Tumor Supratentorial Tumors mouse_pathology.ontology NCIT:C3397 Supratentorial Neoplasm A non-seminomatous germ cell tumor characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). It occurs in the testis, ovary, and extragonadal sites including central nervous system, mediastinum, lung, and stomach. According to the level of differentiation of the tissues which comprise the tumor, teratomas are classified as mature or immature. Mature teratomas are composed of well differentiated, adult-type tissues. Immature teratomas are composed of immature, fetal-type tissues. Testicular teratomas in children follow a benign clinical course. Mature ovarian teratomas without a fetal-type component have an excellent outcome. The prognosis of immature ovarian teratomas is related to the grade and stage of the tumor. Teratoma teratoma mouse_pathology.ontology NCIT:C3403 Teratoma A benign or malignant, primary or metastatic neoplasm involving the tissues of the thorax. Neoplasm of Thorax Neoplasm of the Thorax Thoracic Neoplasm Thoracic Tumor Tumor of Thorax Tumor of the Thorax mouse_pathology.ontology NCIT:C3406 Thoracic Neoplasm A neoplasm arising from the epithelial cells of the thymus. Although thymomas are usually encapsulated tumors, they may invade the capsule and infiltrate the surrounding tissues or even metastasize to distant anatomic sites. The following morphologic subtypes are currently recognized: type A, type B, type AB, metaplastic, micronodular, microscopic, and sclerosing thymoma. Thymomas type B are further subdivided into types B1, B2, and B3. Thymoma type B3 usually has the most aggressive clinical course. Thymoma thymoma mouse_pathology.ontology NCIT:C3411 Thymoma A benign or malignant neoplasm affecting the thyroid gland. Neoplasm of Thyroid Neoplasm of Thyroid Gland Neoplasm of the Thyroid Neoplasm of the Thyroid Gland Thyroid Gland Neoplasm Thyroid Gland Tumor Thyroid Neoplasm Thyroid Neoplasms Thyroid Tumor Tumor of Thyroid Tumor of Thyroid Gland Tumor of the Thyroid Tumor of the Thyroid Gland mouse_pathology.ontology NCIT:C3414 Thyroid Gland Neoplasm A benign or malignant, primary or metastatic neoplasm involving the urinary system. --2003 Neoplasm of Urinary System Neoplasm of Urinary Tract Neoplasm of the Urinary System Neoplasm of the Urinary Tract Tumor of Urinary System Tumor of Urinary Tract Tumor of the Urinary System Tumor of the Urinary Tract Urinary System Neoplasm Urinary System Tumor Urinary Tract Neoplasm Urinary Tract Tumor mouse_pathology.ontology NCIT:C3431 Urinary System Neoplasm An intraventricular papillary neoplasm that originates from the choroid plexus epithelium. It includes the choroid plexus papilloma, atypical choroid plexus papilloma, and choroid plexus carcinoma. Choroid Plexus Neoplasm Choroid Plexus Tumor Neoplasm of Choroid Plexus Neoplasm of the Choroid Plexus Tumor of Choroid Plexus Tumor of the Choroid Plexus choroid plexus tumor mouse_pathology.ontology NCIT:C3473 Choroid Plexus Neoplasm An epithelial or non-epithelial malignant neoplasm that arises from the liver. Representative examples include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, lymphoma, and sarcoma. Primary Malignant Liver Neoplasm Primary Malignant Neoplasm of Liver mouse_pathology.ontology NCIT:C34803 Primary Malignant Liver Neoplasm A primary melanoma arising from atypical melanocytes in the skin. Precursor lesions include acquired and congenital melanocytic nevi, and dysplastic nevi. Several histologic variants have been recognized, including superficial spreading melanoma, acral lentiginous melanoma, nodular melanoma, and lentigo maligna melanoma. Cutaneous Melanoma Malignant Cutaneous Melanoma Malignant Melanoma (of Skin), Stage Unspecified Malignant Melanoma of Skin Malignant Melanoma of Skin Stage Unspecified Melanoma of Skin Melanoma of the Skin Skin Melanoma Skin, Melanoma mouse_pathology.ontology NCIT:C3510 Cutaneous Melanoma A primary or metastatic malignant neoplasm affecting the mediastinum. Representative examples of primary malignant mediastinal neoplasms include malignant germ cell tumors, malignant mesenchymal tumors, lymphomas, and malignant peripheral nerve sheath tumors. A representative example of metastatic malignant neoplasm to the mediastinum is the metastatic carcinoma to the mediastinum from another anatomic site. Cancer of Mediastinum Cancer of the Mediastinum Malignant Mediastinal Neoplasm Malignant Mediastinal Neoplasm NOS Malignant Mediastinal Tumor Malignant Neoplasm of Mediastinum Malignant Neoplasm of the Mediastinum Malignant Tumor of Mediastinum Malignant Tumor of the Mediastinum Mediastinal Cancer mouse_pathology.ontology NCIT:C3549 Malignant Mediastinal Neoplasm A morphologic category that includes neoplasms arising from cells that form and support the nervous system. Such neoplasms include neuroepithelial cell neoplasms and neoplasms that arise from the perineural sheaths (perineurial cell neoplasms and Schwann cell neoplasms). --2003 Neural Neoplasm Neural Tumor Neuroepithelial, Perineurial, and Schwann Cell Neoplasm mouse_pathology.ontology NCIT:C35562 Neuroepithelial, Perineurial, and Schwann Cell Neoplasm A primary or metastatic malignant neoplasm affecting the brain. Brain Cancer Brain Neoplasms, Malignant Cancer of Brain Cancer of the Brain Malignant Brain Neoplasm Malignant Brain Tumor Malignant Neoplasm of Brain Malignant Neoplasm of the Brain Malignant Tumor of Brain Malignant Tumor of the Brain Malignant neoplasm of brain mouse_pathology.ontology NCIT:C3568 Malignant Brain Neoplasm Primary and secondary (metastatic) malignant tumors that occur in the cerebellum. Histologic types include medulloblastomas, high grade (WHO Stage III or IV) cerebellar astrocytomas, lymphomas, gangliogliomas, gliosarcomas, and several other subtypes. The most frequent malignant cerebellar neoplasm of childhood is medulloblastoma. In adults, metastases from other sites are relatively common. Clinical features include ataxia, headache, nausea, dizzyness, nystagmus, diplopia, papilledema, etc. Cancer of Cerebellum Cancer of the Cerebellum Cerebellar Cancer Cerebellar Neoplasm, Malignant Cerebellar Tumor, Malignant Malignant Cerebellar Neoplasm Malignant Cerebellar Neoplasms Malignant Cerebellar Tumor Malignant Neoplasm of Cerebellum Malignant Neoplasm of the Cerebellum Malignant Tumor of Cerebellum Malignant Tumor of the Cerebellum mouse_pathology.ontology NCIT:C3569 Malignant Cerebellar Neoplasm A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma. Endocrine Neoplasm, Malignant Endocrine cancer, NOS Malignant Endocrine Gland Neoplasm Malignant Endocrine Gland Tumor Malignant Endocrine Neoplasm Malignant Endocrine Tumor Malignant Neoplasm of Endocrine Gland Malignant Neoplasm of the Endocrine Gland Malignant Tumor of Endocrine Gland Malignant Tumor of the Endocrine Gland endocrine cancer mouse_pathology.ontology NCIT:C3575 Malignant Endocrine Neoplasm A primary or metastatic malignant neoplasm affecting the tissues of the thorax. Malignant Neoplasm of Thorax Malignant Neoplasm of the Thorax Malignant Thoracic Neoplasm Malignant Thoracic Tumor Malignant Tumor of Thorax Malignant Tumor of the Thorax mouse_pathology.ontology NCIT:C3576 Malignant Thoracic Neoplasm Neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas). --2003 Hematopoietic and Lymphoid System Neoplasm Hematopoietic and Lymphoid System Tumor mouse_pathology.ontology NCIT:C35813 Hematopoietic and Lymphoid System Neoplasm A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. Carcinoma of Head and Neck Carcinoma of the Head and Neck Head and Neck Carcinoma mouse_pathology.ontology NCIT:C35850 Head and Neck Carcinoma Anaplastic Malignant Neoplasm mouse_pathology.ontology NCIT:C36025 Anaplastic Malignant Neoplasm Papillary Neoplasm Papillary Tumor papillary tumor mouse_pathology.ontology NCIT:C36031 Papillary Neoplasm A sporadic or less frequently familial neoplasm, arising from the glandular epithelium of the stomach, small intestine, biliary tract, colon, and rectum. It is a polypoid or flat circumscribed lesion. Morphologically, it is characterized by a proliferation of neoplastic glandular cells and it is associated with dysplasia. According to the growth pattern, it may be classified as tubular, villous, or tubulovillous. The dysplasia is classified as mild, moderate, or severe. The frequency of malignant transformation depends on the size of the lesion and the degree of dysplasia. Larger adenomas with severe dysplastic changes (sometimes called carcinoma in situ) carry a higher risk of progressing to invasive adenocarcinoma. Gastrointestinal adenomas may present as solitary or multifocal lesions. Familial adenomas tend to be multifocal and carry a higher risk of malignant transformation. Digestive System Adenoma GI Adenoma Gastrointestinal Adenoma mouse_pathology.ontology NCIT:C36207 Digestive System Adenoma A benign or malignant, primary or metastatic neoplasm affecting the male and female reproductive system. Neoplasm of Reproductive System Neoplasm of the Reproductive System Reproductive Neoplasm Reproductive System Neoplasm Reproductive System Tumor Reproductive Tumor Tumor of Reproductive System Tumor of the Reproductive System mouse_pathology.ontology NCIT:C3674 Reproductive System Neoplasm A benign, slow growing tumor which may cause symptoms by blocking cerebrospinal fluid pathways. It is characterized by the presence of delicate fibrovascular connective tissue fronds covered by a single layer of epithelial cells. Mitotic activity is extremely low. Surgical resection is usually curative. (Adapted from WHO) Choroid Plexus Papilloma PAPILLOMA, CHOROID PLEXUS, BENIGN Papilloma of Choroid Plexus Papilloma of the Choroid Plexus mouse_pathology.ontology NCIT:C3698 Choroid Plexus Papilloma A benign or malignant, gonadal or extragonadal neoplasm that originates from germ cells. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor. Germ Cell Neoplasm Germ Cell Tumor Neoplasm of Germ Cell Neoplasm of the Germ Cell Tumor of Germ Cell Tumor of the Germ Cell germ cell tumor mouse_pathology.ontology NCIT:C3708 Germ Cell Tumor A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas. Epithelial Neoplasm Epithelial Neoplasms, NOS Epithelioma mouse_pathology.ontology NCIT:C3709 Epithelial Neoplasm A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm constitutes the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems and includes some glial cell precursors. Neuroectodermal Neoplasm Neuroectodermal Tumor Neuroepithelioma PNET Primitive Neuroectodermal Neoplasm Primitive Neuroectodermal Tumor neuroectodermal tumor primitive neuroectodermal tumor mouse_pathology.ontology NCIT:C3716 Primitive Neuroectodermal Tumor A benign or malignant neoplasm arising from the lymphatic vessels. Lymph Vessel Neoplasm Lymph Vessel Tumor Lymphatic Vessel Neoplasm Lymphatic Vessel Tumor Neoplasm of Lymph Vessel Neoplasm of Lymphatic Vessel Neoplasm of the Lymph Vessel Neoplasm of the Lymphatic Vessel Tumor of Lymph Vessel Tumor of Lymphatic Vessel Tumor of the Lymph Vessel Tumor of the Lymphatic Vessel mouse_pathology.ontology NCIT:C3723 Lymphatic Vessel Neoplasm A malignant liver neoplasm that occurs almost exclusively in infants, although isolated cases in older children and adults have been reported. Grossly, hepatoblastoma is solid, well circumscribed, and more often solitary than multiple. Microscopically, most of the tumors are composed exclusively of immature hepatocytic elements. About a fourth of hepatoblastomas contain a stromal component that may be undifferentiated or develop into bone or cartilage. The treatment of choice for hepatoblastoma is surgical excision with adjuvant therapy. Liver transplantation is being increasingly used as well. HBL HEPATOBLASTOMA, MALIGNANT Hepatoblastoma Pediatric Embryonal Hepatoma Pediatric Hepatoblastoma hepatoblastoma mouse_pathology.ontology NCIT:C3728 Hepatoblastoma A malignant neoplasm composed of a carcinomatous epithelial component and a sarcomatous mesenchymal component. Representative examples include malignant mixed mesodermal (Mullerian) tumor of the female reproductive system and carcinosarcoma of the salivary gland and the lung. MIXED TUMOR, MALIGNANT Malignant Mixed Neoplasm Malignant Mixed Tumor mouse_pathology.ontology NCIT:C3729 Malignant Mixed Neoplasm A malignant neoplasm of the lung composed of tubular structures and immature mesenchymal elements, which may differentiate towards skeletal and smooth muscle, cartilage or a combination of muscle and cartilage. This is a nodular tumor found in the periphery of the lung. It can occur at any age. The prognosis is related to the stage of the disease at the time of resection. Pulmonary blastoma is divided into two subtypes: epithelial predominant and biphasic. Blastoma of Lung Blastoma of the Lung Lung Blastoma Pneumoblastoma Pulmonary Blastoma mouse_pathology.ontology NCIT:C3732 Pulmonary Blastoma A lipoma with prominent vascularity. The vascular tissue is more abundant at the periphery of the tumor and contains fibrin thrombi. It occurs more frequently in younger individuals as a painful subcutaneous nodule, often on the arms. ANGIOLIPOMA, BENIGN Angiolipoma mouse_pathology.ontology NCIT:C3733 Angiolipoma A neoplasm with perivascular epithelioid cell differentiation often associated with tuberous sclerosis. It is characterized by a mixture of epithelioid cells, smooth muscle, vessels, and mature adipose tissue. The kidney is the most common site of involvement. Other sites of involvement include the liver, lung, lymph nodes, and retroperitoneum. The vast majority of cases follow a benign clinical course. However, cases of metastatic angiomyolipomas with sarcomatoid features have been described. Angiomyolipoma angiomyolipoma mouse_pathology.ontology NCIT:C3734 Angiomyolipoma A benign, borderline, or malignant neoplasm characterized by the presence of an epithelial and a fibrous component. Representative examples are fibroadenoma and phyllodes tumor. Fibroepithelial Neoplasm Fibroepithelial Tumor mouse_pathology.ontology NCIT:C3743 Fibroepithelial Neoplasm A benign tumor of the breast characterized by the presence of stromal and epithelial elements. It presents as a painless, solitary, slow growing, firm, and mobile mass. It is the most common benign breast lesion. It usually occurs in women of childbearing age. The majority of fibroadenomas do not recur after complete excision. A slightly increased risk of developing cancer within fibroadenomas or in the breast tissue of patients previously treated for fibroadenomas has been reported. Breast Fibroadenoma FIBROADENOMA, BENIGN Fibroadenoma Fibroadenoma of Breast Fibroadenoma of the Breast fibroadenoma mouse_pathology.ontology NCIT:C3744 Fibroadenoma A rapidly growing malignant mesenchymal neoplasm. It is characterized by the presence of round cells with myoblastic differentiation and a fibrovascular stroma resembling an alveolar growth pattern. The tumor usually presents in the extremities. ARMS Alveolar Rhabdomyosarcoma Alveolar rhabdomyosarcoma Monomorphous Round Cell Rhabdomyosarcoma alveolar rhabdomyosarcoma mouse_pathology.ontology NCIT:C3749 Alveolar Rhabdomyosarcoma A benign or malignant myomatous neoplasm arising from smooth muscle. Neoplasm of Smooth Muscle Neoplasm of the Smooth Muscle Smooth Muscle Neoplasm Smooth Muscle Tumor Tumor of Smooth Muscle Tumor of the Smooth Muscle mouse_pathology.ontology NCIT:C3751 Smooth Muscle Neoplasm A mixed germ cell/sex cord-stromal tumor characterized by the presence of large germ cells which resemble seminoma cells and small cells which resemble Sertoli or granulosa cells. It occurs in the testis and the ovary and is identified in children and adults. It is often associated with gonadal dysgenesis and abnormal karyotype. Gonadoblastoma mouse_pathology.ontology NCIT:C3754 Gonadoblastoma A germ cell tumor characterized by the presence of an embryonal carcinoma component and a teratoma component. Mixed Embryonal Carcinoma and Teratoma Teratocarcinoma teratocarcinoma mouse_pathology.ontology NCIT:C3756 Mixed Embryonal Carcinoma and Teratoma A benign epithelial neoplasm arising from the hepatocytes. Grossly, it appears as a soft, round mass which often contains areas of hemorrhage and necrosis. Morphologically, the neoplastic cells resemble normal hepatocytes and form plates separated by sinusoids. Most patients have a history of contraceptive or anabolic steroids use. ADENOMA, HEPATOCELLULAR, BENIGN Adenoma of Liver Cells Adenoma of the Liver Cells HCA Hepatocellular Adenoma Liver Cell Adenoma mouse_pathology.ontology NCIT:C3758 Hepatocellular Adenoma A polypoid neoplasm arising from the glandular epithelium. There is proliferation of glandular cells which may display dysplastic cytologic features. Representative examples include the adenomatous polyps of the colon and rectum. Adenomatous Polyp Polypoid Adenoma mouse_pathology.ontology NCIT:C3764 Adenomatous Polyp A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma. NEC Neuroendocrine Carcinoma Neuroendocrine cancer, NOS mouse_pathology.ontology NCIT:C3773 Neuroendocrine Carcinoma A neoplastic proliferation of basal cells in the epidermis (part of the skin) or other anatomic sites (most frequently the salivary glands). The basal cell neoplastic proliferation in the epidermis results in basal cell carcinomas. The basal cell neoplastic proliferation in the salivary glands can be benign, resulting in basal cell adenomas or malignant, resulting in basal cell adenocarcinomas. Basal Cell Neoplasm Basal Cell Tumor mouse_pathology.ontology NCIT:C3784 Basal Cell Neoplasm A benign or malignant neoplasm arising from mesothelial cells. Mesothelial cells are the lining cells of the pleura and peritoneum. -- 2003 Mesothelial Neoplasm Mesothelial Tumor mouse_pathology.ontology NCIT:C3786 Mesothelial Neoplasm A neoplasm of the nervous system that arises from the neuroepithelial tissues. Representative examples include astrocytic tumors, oligodendroglial tumors, ependymal tumors, and primitive neuroectodermal tumors. Neoplasm of Neuroepithelial Tissue Neoplasm of Neuroepithelium Neoplasm of the Neuroepithelium Neuroepithelial Neoplasm Neuroepithelial Neoplasms Neuroepithelial Tissue Neoplasm Neuroepithelial Tissue Tumor Neuroepithelial Tumor Neuroepithelial Tumors Tumor of Neuroepithelial Tissue Tumor of Neuroepithelium Tumor of the Neuroepithelium mouse_pathology.ontology NCIT:C3787 Neuroepithelial Neoplasm A neoplasm that is composed of squamous epithelial cells. Squamous cell carcinoma is a representative example. Epidermoid Cell Neoplasm Epidermoid Cell Tumor Squamous Cell Neoplasm Squamous Cell Tumor mouse_pathology.ontology NCIT:C3792 Squamous Cell Neoplasm A neoplasm arising in the ovary or testis. It is composed of granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute the only cellular component that is present in the neoplasm or it may be mixed with other cell types in various combinations. The prognosis can not always be predicted on histologic grounds alone. Approximately, 10% of these tumors may metastasize. Representative examples include granulosa cell tumor, Leydig cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group. Sex Cord-Stromal Neoplasm Sex Cord-Stromal Tumor sex cord tumor sex cord-gonadal stromal tumor sex cord-stromal tumor mouse_pathology.ontology NCIT:C3794 Sex Cord-Stromal Tumor An uncommon, highly aggressive malignant tumor, arising from the peripheral nerves and affecting mostly adults in their third to sixth decades of life. It usually occurs in medium-sized and large nerves of the buttock, thigh, upper arm, or the paraspinal region. It may be associated with neurofibromatosis 1 (NF1). MPNST Malig. periph. nerve sheath tum. Malignant Neoplasm of Peripheral Nerve Sheath Malignant Neoplasm of the Peripheral Nerve Sheath Malignant Neurilemmoma Malignant Neurilemoma Malignant Peripheral Nerve Sheath Neoplasm Malignant Peripheral Nerve Sheath Tumor Malignant Peripheral Nerve Sheath Tumour Malignant Schwannoma Malignant Tumor of Peripheral Nerve Sheath Malignant Tumor of the Peripheral Nerve Sheath Malignant peripheral nerve sheath tumor Neurofibrosarcoma Neurofibrosarcoma, Malignant Neurogenic Sarcoma SCHWANNOMA, MALIGNANT malignant peripheral nerve sheath tumor mouse_pathology.ontology NCIT:C3798 Malignant Peripheral Nerve Sheath Tumor A morphologic variant of fibroma characterized by the presence of numerous dilated vascular channels. ANGIOFIBROMA, BENIGN Angiofibroma Angiofibromatous Hyperplasia Fibroangioma, Benign Fibrous Papule Telangiectatic Fibroma mouse_pathology.ontology NCIT:C3799 Angiofibroma A WHO grade I tumor of uncertain histogenesis which is composed of stromal cells and abundant capillaries. Approximately 25% of hemangioblastomas are associated with Von Hippel-Lindau disease, a disease inherited through an autosomal dominant trait and characterized by the development of hemangioblastomas of the central nervous system and retina, clear cell renal carcinoma, pheochromocytoma, and pancreatic and inner ear tumors. (Adapted from WHO) Angioblastoma Capillary Hemangioblastoma Hemangioblastoma mouse_pathology.ontology NCIT:C3801 Hemangioblastoma A benign or malignant neoplasm composed of cells of neuroendocrine origin. Representative examples include paraganglioma, carcinoid tumor, and neuroendocrine carcinoma. Neuroendocrine Neoplasm Neuroendocrine Tumor neuroendocrine tumor mouse_pathology.ontology NCIT:C3809 Neuroendocrine Neoplasm A benign, intermediate, or malignant neoplasm that affects the connective and soft tissue. Connective and Soft Tissue Neoplasm Connective and Soft Tissue Tumor Musculoskeletal and Soft Tissue Neoplasm Musculoskeletal and Soft Tissue Tumor Neoplasm of Skeletal and Soft Tissue Neoplasm of Soft Tissue and Bone Neoplasm of Soft Tissue and Skeleton Skeletal and Soft Tissue Neoplasm Skeletal and Soft Tissue Tumor Soft Tissue and Bone Neoplasm Soft Tissue and Bone Tumor Tumor of Skeletal and Soft Tissue Tumor of Soft Tissue and Bone Tumor of Soft Tissue and Skeleton mouse_pathology.ontology NCIT:C3810 Connective and Soft Tissue Neoplasm A soft tissue mesenchymal tumor with perivascular epithelioid cell differentiation. Representative examples include angiomyolipoma, clear cell-sugar-tumor of the lung, and lymphangioleiomyomatosis. Neoplasm with Perivascular Epithelioid Cell Differentiation PEComa Tumor with Perivascular Epithelioid Cell Differentiation mouse_pathology.ontology NCIT:C38150 PEComa A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy. C Cell Carcinoma CARCINOMA, C-CELL, MALIGNANT MTC Medullary Carcinoma Medullary Carcinoma of Thyroid Medullary Carcinoma of Thyroid Gland Medullary Carcinoma of the Thyroid Medullary Carcinoma of the Thyroid Gland Medullary Thyroid Cancer Medullary Thyroid Carcinoma Medullary Thyroid Gland Carcinoma Medullary thyroid carcinoma Parafollicular Cell Carcinoma Thyroid Gland Medullary Carcinoma Thyroid Gland Neuroendocrine Carcinoma Thyroid Medullary Carcinoma medullary thyroid cancer mouse_pathology.ontology NCIT:C3879 Thyroid Gland Medullary Carcinoma A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble "oat cells" under the microscope. Small cell carcinoma most often affects the lungs. Clinically, this is often a rapidly growing cancer that spreads to distant sites early. Oat Cell Cancer Oat Cell Carcinoma Small Cell Cancer Small Cell Carcinoma Small Cell NEC Small Cell Neuroendocrine Carcinoma Small cell car. (extrapulmonary) Small cell carcinoma (extrapulmonary) oat cell cancer mouse_pathology.ontology NCIT:C3915 Small Cell Carcinoma A sex cord-stromal tumor of the testis or the ovary. It is characterized by the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom is a slow growing testicular mass. Most cases follow a benign clinical course. In females it may present with estrogenic or androgenic manifestations. The vast majority of cases have a benign clinical course. Sertoli Cell Tumor mouse_pathology.ontology NCIT:C39976 Sertoli Cell Tumor A malignant tumor that occurs in children. Representative examples include soft tissue and bone sarcomas (e.g. osteosarcoma) and embryonal neoplasms (e.g. hepatoblastoma and rhabdoid tumor). Childhood Cancer Childhood Malignant Neoplasm Malignant Childhood Neoplasm Malignant Childhood Tumor Malignant Pediatric Neoplasm Malignant Pediatric Tumor Pediatric Cancer mouse_pathology.ontology NCIT:C4005 Childhood Malignant Neoplasm A primary or metastatic malignant neoplasm affecting the head and neck. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. Cancer of Head and Neck Cancer of the Head and Neck Head and Neck Cancer Head and neck cancer, NOS Malignant Head and Neck Neoplasm Malignant Head and Neck Tumor Malignant Neoplasm of Head and Neck Malignant Neoplasm of the Head and Neck Malignant Tumor of Head and Neck Malignant Tumor of the Head and Neck head and neck cancer mouse_pathology.ontology NCIT:C4013 Malignant Head and Neck Neoplasm A primary or metastatic malignant neoplasm affecting the bone or articular cartilage. Bone Cancer Bone cancer Bone cancer, NOS Cancer of Bone Cancer of the Bone Malignant Bone Neoplasm Malignant Bone Tumor Malignant Neoplasm of Bone Malignant Neoplasm of the Bone Malignant Osseous Neoplasm Malignant Osseous Tumor Malignant Tumor of Bone Malignant Tumor of the Bone Osseous Cancer bone cancer mouse_pathology.ontology NCIT:C4016 Malignant Bone Neoplasm A benign or malignant biphasic neoplasm that arises from the breast parenchyma. It is characterized by the presence of an epithelial and a mesenchymal (stromal) component. The typical examples are fibroadenoma and phyllodes tumor. Breast Fibroepithelial Neoplasm Breast Fibroepithelial Tumor mouse_pathology.ontology NCIT:C40405 Breast Fibroepithelial Neoplasm An embryonal pediatric tumor of the kidney which may also be seen rarely in adults. The peak incidence of Wilms tumor is between the second and fifth year of life. Microscopically, it is composed of a mixture of cellular elements (blastemal, stromal, and epithelial). The most common sites of metastasis include the regional lymph nodes, lungs, and liver. Embryonal Nephroma Kidney Wilms Tumor NEPHROBLASTOMA, MALIGNANT Nephroblastoma Renal Wilms Tumor Renal Wilms' Tumor Wilms Tumor of the Kidney Wilms' Tumor of the Kidney Wilms' tumor mouse_pathology.ontology NCIT:C40407 Kidney Wilms Tumor A benign or malignant mesenchymal neoplasm arising from smooth, skeletal, or cardiac muscle. Muscle Neoplasm Muscle Tumor Myomatous Neoplasm Myomatous Tumor Neoplasm of Muscle Neoplasm of the Muscle Tumor of Muscle Tumor of the Muscle mouse_pathology.ontology NCIT:C4063 Myomatous Neoplasm Multiple Polyps Polyposis polyposis mouse_pathology.ontology NCIT:C4089 Polyposis A neoplasm arising from the epithelial cells. It is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign epithelial neoplasms remain confined to the original site of growth and only rarely metastasize to other anatomic sites. Benign Epithelial Neoplasm Benign Epithelial Tumor Benign Epithelioma Benign Neoplasm of Epithelium Benign Neoplasm of the Epithelium Benign Tumor of Epithelium Benign Tumor of the Epithelium EPITHELIOMA, BENIGN mouse_pathology.ontology NCIT:C4092 Benign Epithelial Neoplasm A condition in which multiple adenomas develop in the gastrointestinal tract. Multiple Adenomatous Polyps mouse_pathology.ontology NCIT:C4135 Multiple Adenomatous Polyps A benign, malignant, or borderline neoplasm characterized by the presence of papillary mucinous, serous, or clear cell structures and cystic structures. Papillary Cystic Neoplasm Papillary Cystic Tumor mouse_pathology.ontology NCIT:C4179 Papillary Cystic Neoplasm A benign or malignant paraganglioma arising from the chromaffin cells of the paraganglia that are located along the sympathetic nerves. It includes extra-adrenal paragangliomas and paragangliomas that arise from the adrenal medulla. The latter are commonly referred to as pheochromocytomas. Representative examples of extra-adrenal sympathetic paragangliomas include the bladder, and superior and inferior paraaortic paragangliomas. Clinical signs are related to the secretion of catecholamines resulting in hypertension. Chromaffin Neoplasm Chromaffin Tumor Chromaffinoma Sympathetic Paraganglioma Sympathetic Paraganglionic Neoplasm mouse_pathology.ontology NCIT:C4216 Sympathetic Paraganglioma A non-metastasizing neoplasm that arises from the soft tissue. Benign Neoplasm of Soft Tissue Benign Neoplasm of the Soft Tissue Benign Soft Tissue Neoplasm Benign Soft Tissue Tumor Benign Tumor of Soft Tissue Benign Tumor of the Soft Tissue mouse_pathology.ontology NCIT:C4242 Benign Soft Tissue Neoplasm A benign, intermediate, or malignant mesenchymal neoplasm composed of adipose (fatty) tissue. Adipose Tissue Neoplasm Adipose Tissue Tumor Lipomatous Neoplasm Lipomatous Tumor Neoplasm of Adipose Tissue Neoplasm of the Adipose Tissue Tumor of Adipose Tissue Tumor of the Adipose Tissue mouse_pathology.ontology NCIT:C4248 Lipomatous Neoplasm A malignant germ cell tumor characterized by the presence of at least two different germ cell components. The different germ cell components include choriocarcinoma, embryonal carcinoma, yolk sac tumor, teratoma, and seminoma. It occurs in the ovary, testis, and extragonadal sites including central nervous system and mediastinum. Combined Germ Cell Neoplasm Combined Germ Cell Tumor Mixed Germ Cell Neoplasm Mixed Germ Cell Tumor mouse_pathology.ontology NCIT:C4290 Mixed Germ Cell Tumor Germinative Follicular Epithelium Neoplasm Germinative Follicular Epithelium Tumor mouse_pathology.ontology NCIT:C43311 Germinative Follicular Epithelium Neoplasm Benign Germinative Follicular Epithelium Neoplasm Benign Germinative Follicular Epithelium Tumor mouse_pathology.ontology NCIT:C43319 Benign Germinative Follicular Epithelium Neoplasm A carcinoma that arises from the intrahepatic biliary tree (intrahepatic cholangiocarcinoma) or from the junction, or adjacent to the junction, of the right and left hepatic ducts (hilar cholangiocarcinoma). Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor. CC CHOLANGIOCARCINOMA, MALIGNANT Cholangiocar.- intra/extrahepatic Cholangiocarcinoma Cholangiocarcinoma, intrahepatic and extrahepatic bile ducts (adenocarcinoma) Cholangiocellular Carcinoma cholangiocarcinoma cholangiosarcoma mouse_pathology.ontology NCIT:C4436 Cholangiocarcinoma A benign or malignant neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands. Adnexal Neoplasm of skin Adnexal Neoplasm of the skin Adnexal Tumor of skin Adnexal Tumor of the skin Cutaneous Adnexal Neoplasm Epidermal Appendage Neoplasm Epidermal Appendage Tumor Neoplasm of Epidermal Appendage Neoplasm of Skin Appendage Neoplasm of the Skin Appendage Skin Appendage Neoplasm Skin Appendage Tumor Tumor of Epidermal Appendage Tumor of Skin Appendage Tumor of the Skin Appendage mouse_pathology.ontology NCIT:C4463 Skin Appendage Neoplasm A benign mesenchymal neoplasm composed of adipose (fatty) tissue. The most common representative of this category is the lipoma. Benign Adipose Tissue Neoplasm Benign Adipose Tissue Tumor Benign Lipomatous Neoplasm Benign Lipomatous Tumor Benign Neoplasm of Adipose Tissue Benign Neoplasm of the Adipose Tissue Benign Tumor of Adipose Tissue Benign Tumor of the Adipose Tissue mouse_pathology.ontology NCIT:C4502 Benign Lipomatous Neoplasm A rare, aggressive, poorly differentiated, non-small cell lung carcinoma characterized by the presence of a sarcomatoid component often associated with giant cell differentiation. There is a male to female ratio of 4:1. Clinical symptoms include cough, hemoptysis, chest pain, progressive dyspnea and fever secondary to recurrent pneumonia. Cigarette smoking is a major risk factor. Lung Sarcomatoid Carcinoma mouse_pathology.ontology NCIT:C45540 Lung Sarcomatoid Carcinoma A primary or metastatic malignant neoplasm that affects the lung parenchyma, bronchial tree, or trachea. Representative examples include lung carcinoma, carcinoid tumor, lung lymphoma, lung sarcoma, and tracheal carcinoma. Malignant Neoplasm of Respiratory Tract Malignant Neoplasm of the Respiratory Tract Malignant Respiratory Tract Neoplasm Malignant Respiratory Tract Tumor Malignant Tumor of Respiratory Tract Malignant Tumor of the Respiratory Tract mouse_pathology.ontology NCIT:C4571 Malignant Respiratory Tract Neoplasm A non-metastasizing neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands. Representative examples include cylindroma, hidrocystoma, hidradenoma, and sebaceoma. Benign Cutaneous Adnexal Neoplasm Benign Epidermal Appendage Neoplasm Benign Epidermal Appendage Tumor Benign Neoplasm of Epidermal Appendage Benign Neoplasm of the Epidermal Appendage Benign Skin Appendage Neoplasm Benign Tumor of Epidermal Appendage Benign Tumor of the Epidermal Appendage mouse_pathology.ontology NCIT:C4615 Benign Skin Appendage Neoplasm A primary or metastatic malignant neoplasm involving the brain or spinal cord. Representative examples include anaplastic astrocytoma, glioblastoma, anaplastic (malignant) meningioma, lymphoma, and metastatic carcinoma from another anatomic site. CNS Cancer CNS Malignant Neoplasms CNS Neoplasms, Malignant Cancer of CNS Cancer of Central Nervous System Cancer of the CNS Cancer of the Central Nervous System Central Nervous System Cancer Central Nervous System Neoplasms, Malignant Malignant CNS Neoplasm Malignant CNS Neoplasms Malignant CNS Tumor Malignant Central Nervous System Neoplasm Malignant Central Nervous System Tumor Malignant Neoplasm of CNS Malignant Neoplasm of Central Nervous System Malignant Neoplasm of the CNS Malignant Neoplasm of the Central Nervous System Malignant Tumor of CNS Malignant Tumor of Central Nervous System Malignant Tumor of the CNS Malignant Tumor of the Central Nervous System mouse_pathology.ontology NCIT:C4627 Malignant Central Nervous System Neoplasm A clonal proliferation of immunoglobulin-secreting plasma cells. This category includes plasma cell myeloma, plasma cell leukemia, plasmacytoma, monoclonal immunoglobulin deposition disease, and monoclonal gammopathy of undetermined significance. PLASMA CELL TUMOR, MALIGNANT Plasma Cell Dyscrasia Plasma Cell Neoplasm Plasma Cell Tumor Plasmacytic Neoplasm Plasmacytic Tumor Plasmacytic Tumour plasma cell tumor mouse_pathology.ontology NCIT:C4665 Plasma Cell Neoplasm A classification system grouping neoplasms according to their cellular characteristics. Neoplasm by Morphology mouse_pathology.ontology NCIT:C4741 Neoplasm by Morphology A benign, intermediate, or malignant cartilaginous matrix-producing neoplasm. Representative examples include osteochondroma, chondroblastoma, and chondrosarcoma. Cartilaginous Neoplasm Cartilaginous Tumor Chondrogenic Neoplasm Chondrogenic Tumor Chondromatous Neoplasm Chondromatous Tumor Neoplasm of Cartilage Neoplasm of the Cartilage Tumor of Cartilage Tumor of the Cartilage mouse_pathology.ontology NCIT:C4755 Chondrogenic Neoplasm A primary or metastatic malignant neoplasm involving the structures of the eye (conjunctiva, cornea, uvea, retina), the lacrimal gland, and the eyelid. Representative examples include melanoma, carcinoma, lymphoma, and retinoblastoma. Cancer of Eye Cancer of the Eye Eye Cancer Eye Neoplasm, Malignant Malignant Eye Neoplasm Malignant Eye Tumor Malignant Neoplasm of Eye Malignant Neoplasm of the Eye Malignant Ocular Neoplasm Malignant Ocular Tumor Malignant Tumor of Eye Malignant Tumor of the Eye Malignant eye cancer, NOS eye cancer mouse_pathology.ontology NCIT:C4767 Malignant Eye Neoplasm A primary, slow growing, noninvasive neoplasm of the brain. In children, astrocytomas of the cerebellum represent relatively common benign brain neoplasms. In adults meningiomas, neurilemomas and pituitary tumors comprise the majority of benign tumors. Benign Brain Neoplasm Benign Brain Tumor Benign Neoplasm of Brain Benign Neoplasm of the Brain Benign Tumor of Brain Benign Tumor of the Brain Benign neoplasm of brain Brain Neoplasms, Benign mouse_pathology.ontology NCIT:C4781 Benign Brain Neoplasm A benign or malignant neoplasm that affects the heart and/or vessels. Representative examples of benign neoplasms include atrial myxoma, hemangioma, and lymphangioma. Representative examples of malignant neoplasms include pericardial malignant mesothelioma and angiosarcoma. Cardiovascular Neoplasm Cardiovascular Tumor mouse_pathology.ontology NCIT:C4784 Cardiovascular Neoplasm A primary or metastatic malignant neoplasm involving the nervous system. Malignant Neoplasm of Nervous System Malignant Neoplasm of the Nervous System Malignant Nervous System Neoplasm Malignant Nervous System Tumor Malignant Tumor of Nervous System Malignant Tumor of the Nervous System Nervous System Neoplasms, Malignant mouse_pathology.ontology NCIT:C4788 Malignant Nervous System Neoplasm A benign or malignant neoplasm affecting the retina. Representative examples of benign neoplasms include retinocytoma and hemangioma. Representative examples of malignant neoplasms include retinoblastoma, lymphoma and melanoma. Neoplasm of Retina Neoplasm of the Retina Retina Neoplasm Retina Tumor Retinal Neoplasm Retinal Tumor Tumor of Retina Tumor of the Retina mouse_pathology.ontology NCIT:C4800 Retinal Neoplasm A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic. Cancer of Thyroid Cancer of the Thyroid Carcinoma of Thyroid Carcinoma of Thyroid Gland Carcinoma of the Thyroid Carcinoma of the Thyroid Gland Head and Neck Cancer, Thyroid Thyroid Cancer Thyroid Carcinoma Thyroid Gland Cancer Thyroid Gland Carcinoma Thyroid cancer Thyroid cancer, NOS thyroid cancer mouse_pathology.ontology NCIT:C4815 Thyroid Gland Carcinoma A malignant tumor of neuroglial tissue. This term may be used to describe one of a number of primary neoplasms of the brain and spinal cord, including astrocytomas, ependymomas, neurocytomas, etc. Malignant gliomas are the most common primary tumors of the brain. GLIOMA, MALIGNANT Malignant Glial Neoplasm Malignant Glial Tumor Malignant Glioma Malignant Neuroglial Neoplasm Malignant Neuroglial Tumor mouse_pathology.ontology NCIT:C4822 Malignant Glioma A benign or malignant (primary or metastatic) neoplasm affecting the adrenal medulla. (NCI05) Adrenal Medulla Neoplasm Adrenal Medulla Tumor mouse_pathology.ontology NCIT:C4856 Adrenal Medulla Neoplasm A malignant neoplasm arising exclusively from the soft tissues. Malignant Neoplasm of Soft Tissue Malignant Neoplasm of the Soft Tissue Malignant Soft Tissue Neoplasm Malignant Soft Tissue Tumor Malignant Tumor of Soft Tissue Malignant Tumor of the Soft Tissue mouse_pathology.ontology NCIT:C4867 Malignant Soft Tissue Neoplasm A carcinoma originating in the lung. Lung carcinomas usually arise from the epithelium that lines the bronchial tree (bronchogenic carcinomas), and are classified as small cell or non-small cell carcinomas. Non-small cell lung carcinomas are usually adenocarcinomas, squamous cell carcinomas, or large cell carcinomas. Metastatic carcinomas to the lung are also common, and can be difficult to distinguish from primary tumors. Cancer of Lung Cancer of the Lung Carcinoma of Lung Carcinoma of the Lung Lung Cancer Lung Carcinoma Lung cancer, NOS lung cancer mouse_pathology.ontology NCIT:C4878 Lung Carcinoma A neoplasm that arises from the bone or articular cartilage and does not invade adjacent tissues or metastasize to other anatomic sites. Benign Bone Neoplasm Benign Bone Tumor Benign Neoplasm of Bone Benign Neoplasm of the Bone Benign Osseous Neoplasm Benign Osseous Tumor Benign Tumor of Bone Benign Tumor of the Bone mouse_pathology.ontology NCIT:C4880 Benign Bone Neoplasm A benign mesenchymal neoplasm arising from smooth, skeletal, or cardiac muscle tissue. Benign Muscle Neoplasm Benign Muscle Tumor Benign Neoplasm of Muscle Benign Neoplasm of the Muscle Benign Tumor of Muscle Benign Tumor of the Muscle Myoma mouse_pathology.ontology NCIT:C4882 Benign Muscle Neoplasm A malignant neoplasm affecting the skeletal or smooth muscles. Malignant neoplasms arising from the skeletal muscles are called rhabdomyosarcomas. Malignant neoplasms arising from the smooth muscles are called leiomyosarcomas. Malignant Muscle Neoplasm Malignant Muscle Tumor Malignant Neoplasm of Muscle Malignant Neoplasm of the Muscle Malignant Tumor of Muscle Malignant Tumor of the Muscle Myosarcoma mouse_pathology.ontology NCIT:C4883 Malignant Muscle Neoplasm A primary or metastatic malignant neoplasm involving any part of the digestive system. Gastrointestinal System Cancer Gastrointestinal cancer, NOS Malignant Digestive System Neoplasm Malignant Gastrointestinal Neoplasm Malignant Gastrointestinal System Neoplasm mouse_pathology.ontology NCIT:C4890 Malignant Digestive System Neoplasm A carcinoma that arises from the skin. Representative examples are basal cell carcinoma and squamous cell carcinoma. Carcinoma of Skin Carcinoma of the Skin Non-Melanoma Cancer of Skin Non-Melanoma Cancer of the Skin Non-Melanoma Skin Cancer Skin Cancer, Non-Melanoma Skin Carcinoma nonmelanoma skin cancer mouse_pathology.ontology NCIT:C4914 Skin Carcinoma A gonadal or extragonadal malignant neoplasm that arises from germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, and seminoma. Germ cell cancer, NOS Malignant Germ Cell Neoplasm Malignant Germ Cell Tumor Malignant Neoplasm of Germ Cell Malignant Neoplasm of the Germ Cell Malignant Tumor of Germ Cell Malignant Tumor of the Germ Cell mouse_pathology.ontology NCIT:C4925 Malignant Germ Cell Tumor A primary or metastatic malignant neoplasm that affects the anatomic structures of the neck region. Cancer of Neck Cancer of the Neck Malignant Neck Neoplasm Malignant Neck Tumor Malignant Neoplasm of Neck Malignant Neoplasm of the Neck Malignant Tumor of Neck Malignant Tumor of the Neck Neck Cancer mouse_pathology.ontology NCIT:C4940 Malignant Neck Neoplasm A benign or malignant neoplasm that arises from or metastasizes to structures within the cranium. This includes meningeal and other tumors that occur in the spaces that surround the brain, and neoplasms of the brain. Intracranial Central Nervous System Neoplasm Intracranial Central Nervous System Tumor Intracranial Neoplasm Intracranial Tumor intracranial tumor mouse_pathology.ontology NCIT:C4953 Intracranial Neoplasm Malignant growth of cells in the peripheral nervous system (PNS)or Autonomic Nervous System (ANS), without specification as to location Malignant Neoplasm of PNS Malignant Neoplasm of Peripheral Nerve Malignant Neoplasm of Peripheral Nervous System Malignant Neoplasm of the PNS Malignant Neoplasm of the Peripheral Nerve Malignant Neoplasm of the Peripheral Nervous System Malignant Neoplasms, Peripheral Nerve Malignant PNS Neoplasm Malignant PNS Tumor Malignant Peripheral Nerve Neoplasm Malignant Peripheral Nerve Tumor Malignant Peripheral Nervous System Neoplasm Malignant Peripheral Nervous System Tumor Malignant Tumor of PNS Malignant Tumor of Peripheral Nerve Malignant Tumor of Peripheral Nervous System Malignant Tumor of the PNS Malignant Tumor of the Peripheral Nerve Malignant Tumor of the Peripheral Nervous System Peripheral Nervous System Neoplasms, Malignant mouse_pathology.ontology NCIT:C4961 Malignant Peripheral Nervous System Neoplasm A primary or metastatic malignant neoplasm involving the thymus. This category includes malignant thymomas, thymic lymphomas, primary thymic carcinomas, and metastatic carcinomas from other anatomic sites. Cancer of Thymus Cancer of the Thymus Malignant Neoplasm of Thymus Malignant Neoplasm of the Thymus Malignant Thymus Neoplasm Malignant Thymus Tumor Malignant Tumor of Thymus Malignant Tumor of the Thymus Thymus Cancer mouse_pathology.ontology NCIT:C4962 Malignant Thymus Neoplasm Malignant neoplasms which arise or occur within the intracranial cavity below the tentorium cerebelli. This includes neoplasms within the brain and/or surrounding spaces. Infratentorial Neoplasms, Malignant Malignant Infratentorial Neoplasm Malignant Infratentorial Tumor Malignant Infratentorial Tumors mouse_pathology.ontology NCIT:C4966 Malignant Infratentorial Neoplasm A benign or malignant neoplasm arising from the perineural cells in the sheaths surrounding the nerves. Representative examples include neurofibroma, schwannoma, and malignant peripheral nerve sheath tumor. Neoplasm of Nerve Sheath Neoplasm of the Nerve Sheath Nerve Sheath Neoplasm Nerve Sheath Neoplasms Nerve Sheath Tumor Nerve Sheath Tumors Tumor of Nerve Sheath mouse_pathology.ontology NCIT:C4972 Nerve Sheath Neoplasm Benign Intracranial Neoplasm Benign Intracranial Tumor Intracranial Neoplasms, Benign mouse_pathology.ontology NCIT:C5111 Benign Intracranial Neoplasm Benign and malignant neoplasms which arise from or directly involve the central or peripheral elements of the autonomic nervous system. Autonomic Nervous System Neoplasm Autonomic Nervous System Neoplasms Autonomic Nervous System Tumor Neoplasm of Autonomic Nervous System Neoplasm of the Autonomic Nervous System Tumor of Autonomic Nervous System Tumor of the Autonomic Nervous System mouse_pathology.ontology NCIT:C5112 Autonomic Nervous System Neoplasm Intracranial Cancer Intracranial Neoplasms, Malignant Intracranial Tumors, Malignant Malignant Intracranial Neoplasm Malignant Intracranial Tumor mouse_pathology.ontology NCIT:C5114 Malignant Intracranial Neoplasm A biphasic neoplasm that arises from the ovary or the testis. It is characterized by the presence of neoplastic germ cells and neoplastic sex cord-stromal cells. It includes the gonadoblastoma and mixed germ cell-sex cord stromal tumor, unclassifiable. Mixed Germ Cell-Sex Cord Neoplasm Mixed Germ Cell-Sex Cord Tumor Mixed Germ Cell-Sex Cord-Stromal Neoplasm Mixed Germ Cell-Sex Cord-Stromal Tumor mouse_pathology.ontology NCIT:C5241 Mixed Germ Cell-Sex Cord-Stromal Tumor A non-metastasizing neoplasm that arises from the connective and soft tissue. Representative examples include lipoma, leiomyoma, fibroma, and osteoma. Benign Connective and Soft Tissue Neoplasm Benign Connective and Soft Tissue Tumor Benign Mesenchymal Cell Neoplasm Benign Neoplasm of the Soft Tissue and Bone Benign Tumor of the Soft Tissue and Bone CONNECTIVE AND SOFT TISSUE NEOPLASM, BENIGN mouse_pathology.ontology NCIT:C53684 Benign Connective and Soft Tissue Neoplasm An adenoma that arises from the colon or rectum. The group of colorectal adenomas includes tubular, villous, and tubulovillous adenomas, traditional serrated adenomas, sessile serrated adenomas/polyps, and familial adenomatous polyposis. Adenoma of Large Bowel Adenoma of Large Intestine Adenoma of the Large Bowel Adenoma of the Large Intestine Colorectal Adenoma Large Bowel Adenoma Large Intestine Adenoma mouse_pathology.ontology NCIT:C5673 Colorectal Adenoma A carcinoma that arises from the anatomic structures of the neck region. Carcinoma of Neck Carcinoma of the Neck Neck Carcinoma mouse_pathology.ontology NCIT:C6077 Neck Carcinoma A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma. Astrocytoma astrocytoma mouse_pathology.ontology NCIT:C60781 Astrocytoma A benign or malignant neoplasm arising during childhood. Childhood Neoplasm Childhood Tumor Pediatric Neoplasm Pediatric Tumor mouse_pathology.ontology NCIT:C6283 Childhood Neoplasm An epithelial neoplasm that affects the thymus gland. This category includes thymomas and carcinomas. Epithelial Neoplasm of Thymus Epithelial Neoplasm of the Thymus Epithelial Tumor of Thymus Epithelial Tumor of the Thymus Thymic Epithelial Tumor Thymic Epithelium Neoplasm Thymus Epithelial Neoplasm Thymus Epithelial Tumor mouse_pathology.ontology NCIT:C6450 Thymus Epithelial Neoplasm A lymphoma that arises from the thymus. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma. Lymphoma of Thymus Lymphoma of the Thymus Primary Thymic Lymphoma Thymic Lymphoma Thymus Lymphoma mouse_pathology.ontology NCIT:C6451 Thymic Lymphoma A benign mesenchymal neoplasm arising from smooth muscle tissue. Benign Neoplasm of Smooth Muscle Benign Neoplasm of the Smooth Muscle Benign Smooth Muscle Neoplasm Benign Smooth Muscle Tumor Benign Tumor of Smooth Muscle Benign Tumor of the Smooth Muscle mouse_pathology.ontology NCIT:C6510 Benign Smooth Muscle Neoplasm A malignant neoplasm arising from smooth muscle. Cancer of Smooth Muscle Cancer of the Smooth Muscle Malignant Neoplasm of Smooth Muscle Malignant Neoplasm of the Smooth Muscle Malignant Smooth Muscle Neoplasm Malignant Smooth Muscle Tumor Malignant Tumor of Smooth Muscle Malignant Tumor of the Smooth Muscle Smooth Muscle Cancer mouse_pathology.ontology NCIT:C6511 Malignant Smooth Muscle Neoplasm A benign or malignant mesenchymal neoplasm arising from skeletal muscle. Neoplasm of Skeletal Muscle Neoplasm of the Skeletal Muscle Skeletal Muscle Neoplasm Skeletal Muscle Tumor Tumor of Skeletal Muscle Tumor of the Skeletal Muscle mouse_pathology.ontology NCIT:C6514 Skeletal Muscle Neoplasm A malignant epithelial neoplasm characterized by the absence of neoplastic small epithelial cells. A representative example is the lung non-small cell carcinoma. Non-Small Cell Carcinoma mouse_pathology.ontology NCIT:C65151 Non-Small Cell Carcinoma A malignant neoplasm arising from skeletal muscle. Malignant Neoplasm of Skeletal Muscle Malignant Neoplasm of the Skeletal Muscle Malignant Skeletal Muscle Neoplasm Malignant Skeletal Muscle Tumor Malignant Tumor of Skeletal Muscle Malignant Tumor of the Skeletal Muscle mouse_pathology.ontology NCIT:C6516 Malignant Skeletal Muscle Neoplasm A benign neoplasm arising from the lymphatic vessels. Benign Lymph Vessel Neoplasm Benign Lymph Vessel Tumor Benign Lymphatic Vessel Neoplasm Benign Lymphatic Vessel Tumor Benign Neoplasm of Lymph Vessel Benign Neoplasm of Lymphatic Vessel Benign Neoplasm of the Lymph Vessel Benign Neoplasm of the Lymphatic Vessel Benign Tumor of Lymph Vessel Benign Tumor of Lymphatic Vessel Benign Tumor of the Lymph Vessel Benign Tumor of the Lymphatic Vessel mouse_pathology.ontology NCIT:C6524 Benign Lymphatic Vessel Neoplasm A benign soft tissue neoplasm characterized by the presence of spindle and stellate cells, lobulated growth pattern, and myxoid stroma formation. MYXOMA, BENIGN Myxoma mouse_pathology.ontology NCIT:C6577 Myxoma A benign soft tissue tumor in which the line of differentiation is uncertain. Benign Soft Tissue Neoplasm of Uncertain Differentiation Benign Soft Tissue Tumor of Uncertain Differentiation mouse_pathology.ontology NCIT:C6587 Benign Soft Tissue Tumor of Uncertain Differentiation A non-metastasizing bone-forming neoplasm. This category includes osteoma, osteoid osteoma, and osteoblastoma. Benign Osseous Neoplasm Benign Osseous Tumor Benign Osteogenic Neoplasm Benign Osteogenic Tumor mouse_pathology.ontology NCIT:C6602 Benign Osteogenic Neoplasm A benign, intermediate, or malignant bone-forming neoplasm. Representative examples include osteoma, osteoblastoma, and osteosarcoma. Osseous Neoplasm Osseous Tumor Osteogenic Neoplasm Osteogenic Tumor mouse_pathology.ontology NCIT:C6603 Osteogenic Neoplasm A usually aggressive malignant neoplasm arising from the soft tissue. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern. Fibrosarcoma of Soft Tissue Fibrosarcoma of the Soft Tissue Soft Tissue Fibrosarcoma mouse_pathology.ontology NCIT:C6605 Soft Tissue Fibrosarcoma A lymphoma that arises from the mediastinum. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma. Lymphoma of Mediastinum Lymphoma of the Mediastinum Mediastinal Lymphoma Mediastinal Malignant Lymphoma Primary Mediastinal Lymphoma mouse_pathology.ontology NCIT:C6633 Mediastinal Lymphoma A group of neoplasms which arise from the ependymal lining of the cerebral ventricles and from the remnants of the central canal of the spinal cord. Ependymal tumors occur predominantly in children and young adults with varied morphological features and biological behavior. There are 4 types: ependymoma, anaplastic ependymoma, myxopapillary ependymoma and subependymoma. (WHO) Ependymal Neoplasm Ependymal Tumor ependymal tumor mouse_pathology.ontology NCIT:C6770 Ependymal Tumor Transitional Cell Neoplasm Transitional Cell Tumor mouse_pathology.ontology NCIT:C6783 Transitional Cell Neoplasm A benign or malignant neoplasm that contains a single or multiple cystic spaces. Examples include cystadenoma, mucinous cystadenocarcinoma, and serous cystadenocarcinoma. Cystic Neoplasm Cystic Tumor mouse_pathology.ontology NCIT:C6784 Cystic Neoplasm A neoplasm composed of at least two distinct cellular populations. Mixed Neoplasm Mixed Tumor mouse_pathology.ontology NCIT:C6930 Mixed Neoplasm A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma. Astrocytic Neoplasm Astrocytic Tumor Astroglioma mouse_pathology.ontology NCIT:C6958 Astrocytic Tumor A neoplasm of the central nervous system composed predominantly of cells morphologically resembling oligodendroglia. Oligodendroglial tumors histologically comprise a continuous spectrum ranging from well-differentiated neoplasms to frankly malignant tumors. WHO grading system recognizes two malignancy grades: WHO grade II for well-differentiated tumors (oligodendroglioma) and WHO grade III for anaplastic oligodendroglioma. (Adapted from WHO) Oligodendroglial Neoplasm Oligodendroglial Tumor oligodendroglial tumor mouse_pathology.ontology NCIT:C6960 Oligodendroglial Tumor A group of nervous system tumors which display neuronal differentiation. It includes tumors that are composed of immature round cells and tumors that display advanced differentiation and the formation of ganglion cells. Neuroblastic Tumor mouse_pathology.ontology NCIT:C6963 Neuroblastic Tumor A neoplasm that arises from meningothelial cells. This category refers to meningiomas. Meningothelial Cell Neoplasm Meningothelial Cell Tumor Primary Meningeal Neoplasm Primary Meningeal Tumor Tumor of Meningothelial Cells mouse_pathology.ontology NCIT:C6971 Meningothelial Cell Neoplasm Neoplasm of Uncertain Histogenesis Neoplasm of Uncertain Origin Tumor of Uncertain Histogenesis Tumor of Uncertain Origin mouse_pathology.ontology NCIT:C6974 Neoplasm of Uncertain Histogenesis A malignant neoplasm of embryonal origin, arising from the central nervous system. It usually affects children. Representative examples include ependymoblastoma, medulloblastoma, and atypical teratoid/rhabdoid tumor. CNS Embryonal Neoplasm CNS Embryonal Tumor Central Nervous System Embryonal Neoplasm Central Nervous System Embryonal Tumor Embryonal Neoplasm of CNS Embryonal Neoplasm of Central Nervous System Embryonal Neoplasm of the CNS Embryonal Neoplasm of the Central Nervous System Embryonal Tumor of CNS Embryonal Tumor of Central Nervous System Embryonal Tumor of the CNS Embryonal Tumor of the Central Nervous System mouse_pathology.ontology NCIT:C6990 Central Nervous System Embryonal Neoplasm Melanocytic Neoplasm mouse_pathology.ontology NCIT:C7058 Melanocytic Neoplasm A benign, intermediate, or malignant neoplasm that arises from the mesenchyma-derived cells of the soft tissue or bone. Representative examples include lipoma, leiomyoma, leiomyosarcoma and osteosarcoma. Mesenchymal Cell Neoplasm Mesenchymal Cell Tumor Mesenchymal Neoplasm Mesenchymal Tumor mouse_pathology.ontology NCIT:C7059 Mesenchymal Cell Neoplasm Retinal Cell Neoplasm Retinal Cell Tumor mouse_pathology.ontology NCIT:C7061 Retinal Cell Neoplasm A neoplasm defined by its unique characteristic as they apply to clinical presentation and course, morphologic patterns, frequency, and/or age distribution. Neoplasm by Special Category mouse_pathology.ontology NCIT:C7062 Neoplasm by Special Category A bone tumor arising from the remnants of the fetal notochord. This category includes the chordoma and benign notochordal cell tumor. Notochordal Neoplasm Notochordal Tumor mouse_pathology.ontology NCIT:C7063 Notochordal Tumor A neoplasm composed of a lymphocytic cell population which is usually malignant (clonal) by molecular genetic and/or immunophenotypic analysis. Lymphocytic neoplasms include Hodgkin and non-Hodgkin lymphomas, acute and chronic lymphocytic leukemias, and plasma cell neoplasms. Lymphocytic Neoplasm Lymphocytic Tumor Lymphocytic and Plasma Cell Neoplasm Lymphocytic and Plasma Cell Tumor Lymphocytic and Plasma Cell Tumour Lymphocytic and Plasmacytic Neoplasm Lymphoid Neoplasm Lymphoid Tumor Lymphoid and Plasma Cell Tumor Lymphoid and Plasma Cell Tumour Lymphoid and Plasmacytic Neoplasm Lymphoid and Plasmacytic Tumor Lymphoid and Plasmacytic Tumour mouse_pathology.ontology NCIT:C7065 Lymphocytic Neoplasm Neoplastic Polyp mouse_pathology.ontology NCIT:C7068 Neoplastic Polyp A benign, intermediate, or malignant mesenchymal neoplasm characterized by the presence of neoplastic fibroblasts. Fibroblastic Neoplasm Fibroblastic Tumor Fibrocytic Neoplasm Fibrocytic Tumor Fibrogenic Neoplasm FibrogenicTumor Fibrous Neoplasm Fibrous Tumor mouse_pathology.ontology NCIT:C7075 Fibroblastic Neoplasm Common Neoplasm Common Tumor mouse_pathology.ontology NCIT:C7077 Common Neoplasm A benign or malignant neoplasm that affects the liver parenchyma or intrahepatic bile ducts. Representative examples of benign neoplasms include hepatocellular adenoma, and bile duct adenoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and lymphoma. Hepatic and Intrahepatic Bile Duct Neoplasm Liver and Intrahepatic Bile Duct Neoplasm mouse_pathology.ontology NCIT:C7103 Liver and Intrahepatic Bile Duct Neoplasm A benign or malignant epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts. Representative examples of benign epithelial neoplasms include hepatocellular adenoma and intrahepatic bile duct adenoma. Representative examples of malignant epithelial neoplasms include hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Epithelial Hepatic and Intrahepatic Bile Duct Neoplasm Liver and Intrahepatic Bile Duct Epithelial Neoplasm mouse_pathology.ontology NCIT:C7106 Liver and Intrahepatic Bile Duct Epithelial Neoplasm Glandular Cell Epithelial Neoplasm Glandular Cell Epithelium Neoplasm Glandular Cell Neoplasm mouse_pathology.ontology NCIT:C7132 Glandular Cell Neoplasm A benign mesenchymal neoplasm characterized by the presence of neoplastic fibroblasts without malignant characteristics. Benign Fibroblastic Neoplasm Benign Fibroblastic Tumor Benign Fibrocytic Neoplasm Benign Fibrocytic Tumor Benign Fibrogenic Neoplasm Benign Fibrogenic Tumor Benign Fibrous Neoplasm Benign Fibrous Tumor mouse_pathology.ontology NCIT:C7147 Benign Fibroblastic Neoplasm A benign,intermediate, or malignant soft tissue tumor in which the line of differentiation is uncertain. Representative examples include neoplasm with perivascular epithelioid cell differentiation, alveolar soft part sarcoma, desmoplastic small round cell tumor, epithelioid sarcoma, extraskeletal myxoid chondrosarcoma, and synovial sarcoma. Soft Tissue Neoplasm of Uncertain Differentiation Soft Tissue Tumor of Uncertain Differentiation mouse_pathology.ontology NCIT:C7148 Soft Tissue Tumor of Uncertain Differentiation An adenocarcinoma arising from the thyroid gland showing extensive evidence of follicular cell differentiation. According to the nuclear features of the malignant follicular cells, it is classified either as papillary, or follicular carcinoma. Differentiated Thyroid Cancer Differentiated Thyroid Carcinoma Differentiated Thyroid Gland Carcinoma Thyroid Gland Differentiated Carcinoma Thyroid Gland Well Differentiated Carcinoma Well Differentiated Thyroid Carcinoma Well Differentiated Thyroid Gland Carcinoma Well-Differentiated Thyroid Cancer mouse_pathology.ontology NCIT:C7153 Differentiated Thyroid Gland Carcinoma Cutaneous Melanocytic Neoplasm Melanocytic Neoplasm of Skin Melanocytic Skin Neoplasm mouse_pathology.ontology NCIT:C7161 Melanocytic Skin Neoplasm Lymphoma by Site mouse_pathology.ontology NCIT:C7185 Lymphoma by Site Infrequent Neoplasm Infrequent Tumor mouse_pathology.ontology NCIT:C7201 Infrequent Neoplasm A benign or malignant endocrine neoplasm that arises from the testis or the ovary. Reproductive Endocrine Neoplasm Reproductive System Endocrine Neoplasm mouse_pathology.ontology NCIT:C7335 Reproductive Endocrine Neoplasm A benign or malignant, primary or metastatic neoplasm involving the walls and/or cavities of the abdomen, pelvis, and retroperitoneal space. Peritoneal and Retroperitoneal Neoplasms Peritoneal and Retroperitoneal Tumors mouse_pathology.ontology NCIT:C7337 Peritoneal and Retroperitoneal Neoplasms Benign Epithelial Skin Neoplasm Benign Epithelial Skin Tumor Benign Skin Epithelium Neoplasm Benign Skin Epithelium Tumor mouse_pathology.ontology NCIT:C7341 Benign Epithelial Skin Neoplasm Epithelial Skin Neoplasm Epithelial Skin Tumor Skin Epithelium Neoplasm Skin Epithelium Tumor mouse_pathology.ontology NCIT:C7342 Epithelial Skin Neoplasm A benign or malignant neoplasm arising from the hair follicle. Hair Follicle Neoplasm Hair Follicle Tumor Hair Matrix Neoplasm Hair Matrix Tumor Neoplasm of Hair Follicle Neoplasm of the Hair Follicle mouse_pathology.ontology NCIT:C7367 Hair Follicle Neoplasm A benign adnexal neoplasm arising from hair-bearing skin surfaces, usually the head and neck and upper extremities. It usually presents as a solitary, slow-growing nodular mass. Morphologically, it displays differentiation towards the matrix and inner sheath of the normal hair follicle and the hair cortex. Complete surgical excision is usually curative. Occasionally, it may recur. Benign Hair Follicle Neoplasm Benign Pilomatricoma Benign Pilomatrixoma Calcifying Epithelioma of Malherbe Calcifying Epitherlioma of Malherbe PILOMATRIXOMA, BENIGN Pilomatricoma Pilomatrixoma mouse_pathology.ontology NCIT:C7368 Pilomatricoma A primary or metastatic malignant neoplasm involving the lung. Malignant Lung Neoplasm Malignant Lung Tumor Malignant Neoplasm of Lung Malignant Neoplasm of the Lung Malignant Tumor of Lung Malignant Tumor of the Lung mouse_pathology.ontology NCIT:C7377 Malignant Lung Neoplasm A benign neoplasm arising from arteries or veins. Blood Vessel Neoplasm Blood Vessel Tumor mouse_pathology.ontology NCIT:C7387 Blood Vessel Neoplasm A benign, intermediate, or malignant neoplasm arising from vascular tissue including arteries, veins, venous sinuses, lymphatic vessels, arterioles and capillaries. It may occur in essentially any body location and is characterized by the presence of vascular channel formation and endothelial cells. Neoplasm of Vascular Tissue Neoplasms, Vascular Tumor of Vascular Tissue Tumors, Vascular Vascular Neoplasm Vascular Neoplasms Vascular Tissue Neoplasm Vascular Tissue Tumor Vascular Tumor Vascular Tumors Vascular tumor, NOS mouse_pathology.ontology NCIT:C7388 Vascular Neoplasm A benign neoplasm arising from vascular tissue usually of the skin. It is characterized by the presence of vascular channel formation and endothelial cells. Benign Vascular Neoplasm Benign Vascular Tumor Vascular Neoplasms, Benign mouse_pathology.ontology NCIT:C7389 Benign Vascular Neoplasm A malignant neoplasm arising from the vascular tissue. It is characterized by vascular channel formation and malignant endothelial cells. Cancerous Tumor of Blood Vessel Malignant Tumor of Blood Vessel Malignant Vascular Neoplasm Malignant Vascular Tissue Neoplasm Malignant Vascular Tissue Tumor Malignant Vascular Tumor Vascular Neoplasms, Malignant mouse_pathology.ontology NCIT:C7390 Malignant Vascular Neoplasm A benign epithelial neoplasm that projects above the surrounding epithelial surface and consists of villous or arborescent outgrowths of fibrovascular stroma. PAPILLOMA, BENIGN Papilloma mouse_pathology.ontology NCIT:C7440 Papilloma A primary or metastatic malignant neoplasm affecting the thyroid gland. Malignant Neoplasm of Thyroid Malignant Neoplasm of Thyroid Gland Malignant Neoplasm of the Thyroid Malignant Neoplasm of the Thyroid Gland Malignant Thyroid Gland Neoplasm Malignant Thyroid Gland Tumor Malignant Thyroid Neoplasm Malignant Thyroid Tumor Malignant Tumor of Thyroid Malignant Tumor of Thyroid Gland Malignant Tumor of the Thyroid Malignant Tumor of the Thyroid Gland mouse_pathology.ontology NCIT:C7510 Malignant Thyroid Gland Neoplasm Kidney and Ureter Neoplasm Kidney and Ureter Tumor Renal and Ureteral Neoplasm Renal and Ureteral Tumor mouse_pathology.ontology NCIT:C7514 Kidney and Ureter Neoplasm A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. RB RETINOBLASTOMA, MALIGNANT Retinoblastoma retinoblastoma mouse_pathology.ontology NCIT:C7541 Retinoblastoma Primary or metastatic malignant neoplasm involving the kidney. Malignant Kidney Neoplasm Malignant Kidney Tumor Malignant Neoplasm of Kidney Malignant Neoplasm of the Kidney Malignant Renal Neoplasm Malignant Renal Tumor Malignant Tumor of Kidney Malignant Tumor of the Kidney mouse_pathology.ontology NCIT:C7548 Malignant Kidney Neoplasm A neoplasm composed of basal cells that metastasizes to other anatomic sites. Malignant Basal Cell Neoplasm mouse_pathology.ontology NCIT:C7586 Malignant Basal Cell Neoplasm A benign or malignant neoplasm that affects the oral cavity. Mouth Neoplasm Mouth Tumor Oral Cavity Neoplasm Oral Cavity Tumor mouse_pathology.ontology NCIT:C7606 Oral Cavity Neoplasm Common Carcinoma mouse_pathology.ontology NCIT:C7629 Common Carcinoma A malignant neoplasm of the liver developed in childhood. Representative examples include hepatoblastoma, undifferentiated (embryonal) sarcoma, and extrarenal rhabdoid tumor. Childhood Cancer of Liver Childhood Cancer of the Liver Childhood Liver Cancer Childhood Malignant Liver Neoplasm Childhood Malignant Liver Tumor Pediatric Cancer of Liver Pediatric Cancer of the Liver Pediatric Liver Cancer mouse_pathology.ontology NCIT:C7708 Childhood Malignant Liver Neoplasm A carcinoma that arises from the hepatocytes or intrahepatic bile ducts. The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma. Cancer of Liver Cancer of Liver and Intrahepatic Biliary Tract Cancer of the Liver Cancer of the Liver and Intrahepatic Biliary Tract Hepatic Cancer Liver Cancer Liver and Intrahepatic Bile Duct Cancer Liver and Intrahepatic Bile Duct Carcinoma Liver and Intrahepatic Biliary Tract Cancer Liver and Intrahepatic Biliary Tract Carcinoma Liver and hepatobiliary cancer, NOS Liver/hepatobiliary cancer Primary Liver Carcinoma liver cancer mouse_pathology.ontology NCIT:C7927 Liver and Intrahepatic Bile Duct Carcinoma A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. The nuclear features which characterize the thyroid gland papillary carcinoma are absent. Radiation exposure is a risk factor and it comprises approximately 10% to 15% of thyroid cancers. Clinically, it usually presents as a solitary mass in the thyroid gland. It is generally unifocal and thickly encapsulated and shows invasion of the capsule or the vessels. Diagnostic procedures include thyroid ultrasound and fine needle biopsy. CARCINOMA, FOLLICULAR CELL, MALIGNANT Follicular Adenocarcinoma Follicular Cancer of Thyroid Follicular Cancer of Thyroid Gland Follicular Cancer of the Thyroid Follicular Cancer of the Thyroid Gland Follicular Carcinoma Follicular Carcinoma of Thyroid Follicular Carcinoma of Thyroid Gland Follicular Carcinoma of the Thyroid Follicular Carcinoma of the Thyroid Gland Follicular Thyroid Cancer Follicular Thyroid Carcinoma Follicular Thyroid Gland Carcinoma Follicular thyroid carcinoma Thyroid Follicular Carcinoma Thyroid Gland Follicular Carcinoma Well-Differentiated Follicular Adenocarcinoma Well-Differentiated Follicular Carcinoma Well-differentiated Follicular Adenocarcinoma Well-differentiated Follicular Carcinoma follicular thyroid cancer mouse_pathology.ontology NCIT:C8054 Thyroid Gland Follicular Carcinoma Benign Choroid Plexus Neoplasm Benign Choroid Plexus Neoplasms Benign Choroid Plexus Tumor Benign Choroid Plexus Tumors Benign Neoplasm of Choroid Plexus Benign Neoplasm of the Choroid Plexus Benign Tumor of Choroid Plexus Benign Tumor of the Choroid Plexus mouse_pathology.ontology NCIT:C8405 Benign Choroid Plexus Neoplasm Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. N0: No regional lymph node metastases. M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.) Cutaneous Melanoma in situ Malignant Cutaneous Melanoma in situ Malignant Skin Melanoma in situ Melanoma In Situ Melanoma in situ Melanoma in situ of Skin Melanoma in situ of the Skin Skin Melanoma in situ Stage 0 Cutaneous Melanoma Stage 0 Malignant Cutaneous Melanoma Stage 0 Malignant Melanoma Stage 0 Malignant Skin Melanoma Stage 0 Melanoma Stage 0 Melanoma of Skin Stage 0 Melanoma of the Skin Stage 0 Skin Melanoma Stage 0 Skin Melanoma AJCC v6 Stage 0 Skin Melanoma AJCC v7 melanoma in situ stage 0 melanoma mouse_pathology.ontology NCIT:C8423 Stage 0 Skin Melanoma Papillary Epithelial Neoplasm mouse_pathology.ontology NCIT:C8429 Papillary Epithelial Neoplasm A benign neoplasm arising from arteries or veins. Benign Blood Vessel Neoplasm Benign Blood Vessel Tumor mouse_pathology.ontology NCIT:C8537 Benign Blood Vessel Neoplasm A malignant neoplasm arising from the blood vessels. Malignant Blood Vessel Neoplasm Malignant Blood Vessel Tumor mouse_pathology.ontology NCIT:C8538 Malignant Blood Vessel Neoplasm A malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder. Representative examples include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma. Malignant Hepato-Biliary Neoplasm Malignant Hepatobiliary Neoplasm Malignant Liver and Biliary Neoplasm Malignant Liver and Biliary System Neoplasm mouse_pathology.ontology NCIT:C8609 Malignant Hepatobiliary Neoplasm A benign or malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder. Representative examples of benign neoplasms include hepatocellular adenoma, bile duct adenoma, and gallbladder lipoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma. Hepatic and Biliary Neoplasms Hepatic and Biliary Tumors Hepatic, Biliary, and Gallbladder Neoplasms Hepato-Biliary Neoplasm Hepato-Biliary Tumor Hepatobiliary Neoplasm Hepatobiliary Tumor Hepatobiliary Tumors Liver and Biliary Neoplasm Liver and Biliary System Neoplasm mouse_pathology.ontology NCIT:C8614 Hepatobiliary Neoplasm A benign lesion composed of dilated lymphatic channels. Painless swelling is the usual clinical manifestation. LYMPHANGIOMA, BENIGN Lymphangioma mouse_pathology.ontology NCIT:C8965 Lymphangioma A poorly circumscribed morphologic variant of rhabdomyosarcoma. It is characterized by the presence of primitive skeletal muscle differentiation in any stage of myogenesis. ERMS Embryonal Rhabdomyosarcoma Embryonal rhabdomyosarcoma embryonal rhabdomyosarcoma mouse_pathology.ontology NCIT:C8971 Embryonal Rhabdomyosarcoma A benign or malignant neoplasm involving the oral cavity and/or the lips. Lip and Oral Cavity Neoplasm Lip and Oral Cavity Tumor Lip and Oral Cavity Tumour Oral Neoplasm Oral Tumor mouse_pathology.ontology NCIT:C8989 Oral Neoplasm A malignant neoplasm composed of undifferentiated cells. Blastoma Embryoma embryoma mouse_pathology.ontology NCIT:C8997 Blastoma FNCLCC Tumor Grade in Sarcoma Sarcoma by FNCLCC Grade Sarcoma by FNCLCC Tumor Differentiation Score Tumor Differentiation Score in Sarcoma mouse_pathology.ontology NCIT:C9023 Sarcoma by FNCLCC Grade FNCLCC Sarcoma Grade 3 Sarcoma Differentiation Score 3 Sarcoma FNCLCC Grade 3 mouse_pathology.ontology NCIT:C9029 Sarcoma Differentiation Score 3 Cutaneous Melanoma by AJCC v6 Stage mouse_pathology.ontology NCIT:C90514 Cutaneous Melanoma by AJCC v6 Stage A usually aggressive malignant neoplasm of the soft tissue or bone. It arises from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma. Mesenchymal Tumor, Malignant SARCOMA, MALIGNANT Sarcoma Sarcoma of Soft Tissue and Bone Sarcoma of the Soft Tissue and Bone sarcoma mouse_pathology.ontology NCIT:C9118 Sarcoma Cutaneous Melanoma by AJCC v7 Stage mouse_pathology.ontology NCIT:C91231 Cutaneous Melanoma by AJCC v7 Stage A usually aggressive malignant bone-forming mesenchymal neoplasm, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs. OSTEOSARCOMA, MALIGNANT Osteogenic Sarcoma Osteosarcoma osteogenic sarcoma osteosarcoma mouse_pathology.ontology NCIT:C9145 Osteosarcoma A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia. CNS Neoplasm CNS Tumor CNS tumor Central Nervous System Neoplasm Central Nervous System Tumor Neoplasm of CNS Neoplasm of Central Nervous System Neoplasm of the Central Nervous System Tumor of CNS Tumor of Central Nervous System Tumor of the CNS Tumor of the Central Nervous System central nervous system tumor mouse_pathology.ontology NCIT:C9293 Central Nervous System Neoplasm Rare tumors that affect the hematopoietic and lymphoid tissues. The cells of origin are the histiocytes and accessory cells. They can occur at any age and show no significant variations in geographical distribution. This category includes the histiocytic sarcoma, Langerhans cell histiocytosis, Langerhans cell sarcoma, interdigitading dendritic cell sarcoma/tumor, follicular dendritic cell sarcoma/tumor, and dendritic cell sarcoma, not otherwise specified. (WHO, 2001) Histiocytic and Dendritic Cell Neoplasm Histiocytic and Dendritic Cell Neoplasms Histiocytic and Dendritic Cell Tumors mouse_pathology.ontology NCIT:C9294 Histiocytic and Dendritic Cell Neoplasm A primary or metastatic malignant tumor involving the urinary system. Common tumor types include carcinomas, lymphomas, and sarcomas. Malignant Urinary System Neoplasm Malignant Urinary Tract Neoplasm Urothelial tract/bladder cancer, NOS Urothelial/bladder cancer, NOS mouse_pathology.ontology NCIT:C9297 Malignant Urinary System Neoplasm A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. CA Cancer Malignancy Malignant Growth Malignant Neoplasm Malignant Neoplastic Disease Malignant Tumor NEOPLASM, MALIGNANT cancer malignancy mouse_pathology.ontology NCIT:C9305 Malignant Neoplasm A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones. Connective Tissue Sarcoma Non-Rhabdo. soft tissue sarcoma Non-Rhabdomyosarcoma soft tissue sarcoma, NOS Sarcoma of Soft Tissue Sarcoma of the Soft Tissue Soft Tissue Sarcoma Soft tissue sarcoma soft tissue sarcoma mouse_pathology.ontology NCIT:C9306 Soft Tissue Sarcoma A radiosensitive malignant germ cell tumor found in the testis (especially undescended), and extragonadal sites (anterior mediastinum and pineal gland). It is characterized by the presence of uniform cells with clear or dense cytoplasm which contains glycogen, and by a large nucleus which contains one or more nucleoli. The neoplastic germ cells form aggregates separated by fibrous septa. The fibrous septa contain chronic inflammatory cells, mainly lymphocytes. SEMINOMA, MALIGNANT Seminoma Seminoma, Pure seminoma mouse_pathology.ontology NCIT:C9309 Seminoma A benign, intermediate, or malignant neoplasm involving the bone or articular cartilage. Bone Neoplasm Bone Neoplasms Bone Tumor Bone Tumors Neoplasm of Bone Neoplasm of the Bone Osseous Neoplasm Osseous Tumor Tumor of Bone Tumor of the Bone mouse_pathology.ontology NCIT:C9343 Bone Neoplasm A malignant (clonal) proliferation of plasma cells that are cytologically and immunophenotypically identical to those of plasma cell myeloma, but manifest a localized osseous or extraosseous growth pattern. (WHO, 2001) Plasmacytoma plasmacytoma mouse_pathology.ontology NCIT:C9349 Plasmacytoma NCI Tumor Grade in Sarcoma Sarcoma by NCI Grade mouse_pathology.ontology NCIT:C9387 Sarcoma by NCI Grade Sarcoma NCI Grade 3 Sarcoma NCI Grade III mouse_pathology.ontology NCIT:C9415 Sarcoma NCI Grade 3 A polypoid adenoma that arises from and protrudes into the lumen of the colon or rectum. Epithelial dysplasia is always present. According to the architectural pattern it is classified as tubular, tubulovillous, or villous. Adenomatous Polyp of Large Bowel Adenomatous Polyp of the Large Bowel Colorectal Adenomatous Polyp Large Bowel Adenomatous Polyp mouse_pathology.ontology NCIT:C96478 Colorectal Adenomatous Polyp A non-metastasizing neoplasm that arises from the hepatocytes or intrahepatic bile ducts. Representative examples include hepatocellular adenoma and bile duct adenoma. Benign Liver and Intrahepatic Bile Duct Epithelial Neoplasm mouse_pathology.ontology NCIT:C96756 Benign Liver and Intrahepatic Bile Duct Epithelial Neoplasm A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma. Carcinoma of the Gastrointestinal System Digestive System Carcinoma Gastrointestinal System Carcinoma mouse_pathology.ontology NCIT:C96963 Digestive System Carcinoma part of mouse_pathology.ontology part_of