AmiGO 2: Term Details for "MAPK cascade" (GO:0000165)

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Term Information

Accession: GO:0000165
Name: MAPK cascade
Ontology: biological_process
Synonyms: MAP kinase cascade, MAP kinase kinase kinase cascade, MAPK signal transduction, MAPKKK cascade, mitogen-activated protein kinase cascade, MAPK signaling, MAPK signalling, ERK/MAPK cascade, MAPKKK cascade during sporulation
Alternate IDs: GO:0007255
Definition: An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. Source: PMID:9561267, PMID:20811974
Comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
History: See term history for GO:0000165 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to MAPK cascade (excluding "regulates").; Link to all direct and indirect annotations to MAPK cascade (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for MAPK cascade (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical structure
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0141124 intracellular signaling cassette
GO:0000165 MAPK cascade
GO:0070371 ERK1 and ERK2 cascade
GO:0070375 ERK5 cascade
GO:0007254 JNK cascade
GO:0004707 MAP kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0008349 MAP kinase kinase kinase kinase activity
GO:0005078 MAP-kinase scaffold activity
GO:0043409 negative regulation of MAPK cascade
GO:0038066 p38MAPK cascade
GO:0071507 pheromone response MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0043408 regulation of MAPK cascade
GO:0051403 stress-activated MAPK cascade

Parents of MAPK cascade (GO:0000165)

subject	relation	object
MAPK cascade	is_a	intracellular signaling cassette (GO:0141124)
MAPK cascade	RO:0002162	Eukaryota (NCBITaxon:2759)

Children of MAPK cascade (GO:0000165)

subject	relation	object
MAP-kinase scaffold activity (GO:0005078)	BFO:0000050	MAPK cascade
negative regulation of MAPK cascade (GO:0043409)	RO:0002212	MAPK cascade
p38MAPK cascade (GO:0038066)	is_a	MAPK cascade
stress-activated MAPK cascade (GO:0051403)	is_a	MAPK cascade
symbiont-mediated suppression of host MAPK cascade (GO:0141070)	RO:0012014	MAPK cascade
MAP kinase kinase activity (GO:0004708)	BFO:0000050	MAPK cascade
JNK cascade (GO:0007254)	is_a	MAPK cascade
MAP kinase kinase kinase kinase activity (GO:0008349)	BFO:0000050	MAPK cascade
ERK5 cascade (GO:0070375)	is_a	MAPK cascade
regulation of MAPK cascade (GO:0043408)	RO:0002211	MAPK cascade
symbiont-mediated activation of host MAPK cascade (GO:0141071)	RO:0012013	MAPK cascade
ERK1 and ERK2 cascade (GO:0070371)	is_a	MAPK cascade
MAP kinase activity (GO:0004707)	BFO:0000050	MAPK cascade
positive regulation of MAPK cascade (GO:0043410)	RO:0002213	MAPK cascade
pheromone response MAPK cascade (GO:0071507)	is_a	MAPK cascade
MAP kinase kinase kinase activity (GO:0004709)	BFO:0000050	MAPK cascade
symbiont-mediated perturbation of host MAPK cascade (GO:0052080)	RO:0002010	MAPK cascade

Reactome: R-HSA-5673001; R-HSA-169893
Wikipedia: Mitogen-activated_protein_kinase; MAPK_cascade