AmiGO 2: Term Details for "podosome" (GO:0002102)

Accession: GO:0002102
Name: podosome
Ontology: cellular_component
Synonyms: None
Alternate IDs: None
Definition: An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. Source: PMID:15890982, PMID:12837608
Comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
History: See term history for GO:0002102 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to podosome (excluding "regulates").; Link to all direct and indirect annotations to podosome (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for podosome (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
podosome	RO:0002162	cellular organisms (NCBITaxon:131567)
podosome	BFO:0000050	actin cytoskeleton (GO:0015629)
podosome	is_a	intracellular membraneless organelle (GO:0043232)