AmiGO 2: Term Details for "transcription coregulator activity" (GO:0003712)

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Term Information

Accession: GO:0003712
Name: transcription coregulator activity
Ontology: molecular_function
Synonyms: transcription cofactor activity, transcription coreceptor activity, transcriptional co-regulator, RNA polymerase II transcriptional cofactor activity, nuclear receptor coreceptor activity
Alternate IDs: GO:0001104, GO:0016455
Definition: A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. Source: GOC:txnOH-2018, PMID:10213677, PMID:16858867, Wikipedia:Transcription_coregulator, PMID:24203923, PMID:25957681
Comment: Usage guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity.
History: See term history for GO:0003712 at QuickGO
Chem. react.: None
Subset: goslim_drosophila
Related: Link to all genes and gene products annotated to transcription coregulator activity (excluding "regulates").; Link to all direct and indirect annotations to transcription coregulator activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for transcription coregulator activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0003674 molecular_function
GO:0060090 molecular adaptor activity
GO:0030674 protein-macromolecule adaptor activity
GO:0140110 transcription regulator activity
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity

Parents of transcription coregulator activity (GO:0003712)

subject	relation	object
transcription coregulator activity	is_a	protein-macromolecule adaptor activity (GO:0030674)
transcription coregulator activity	is_a	transcription regulator activity (GO:0140110)

Children of transcription coregulator activity (GO:0003712)

subject	relation	object
transcription corepressor activity (GO:0003714)	is_a	transcription coregulator activity
transcription coactivator activity (GO:0003713)	is_a	transcription coregulator activity

GONUTS Add usage comments for this term on the GONUTS wiki.