AmiGO 2: Term Details for "cysteine-type endopeptidase activity" (GO:0004197)

Term Information

Accession: GO:0004197
Name: cysteine-type endopeptidase activity
Ontology: molecular_function
Synonyms: thiol endopeptidase activity, caspase activity, lysosomal cysteine-type endopeptidase, metacaspase activity
Alternate IDs: None
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. Source: https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, GOC:mah
Comment: None
History: See term history for GO:0004197 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to cysteine-type endopeptidase activity (excluding "regulates").; Link to all direct and indirect annotations to cysteine-type endopeptidase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for cysteine-type endopeptidase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0140096 catalytic activity, acting on a protein
GO:0016787 hydrolase activity
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0004175 endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0008303 caspase complex
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0003923 GPI-anchor transamidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:0070137 ubiquitin-like protein-specific endopeptidase activity

Parents of cysteine-type endopeptidase activity (GO:0004197)

subject	relation	object
cysteine-type endopeptidase activity	is_a	endopeptidase activity (GO:0004175)
cysteine-type endopeptidase activity	is_a	cysteine-type peptidase activity (GO:0008234)

Children of cysteine-type endopeptidase activity (GO:0004197)

subject	relation	object
cysteine-type endopeptidase inhibitor activity (GO:0004869)	RO:0002630	cysteine-type endopeptidase activity
caspase complex (GO:0008303)	RO:0002215	cysteine-type endopeptidase activity
positive regulation of cysteine-type endopeptidase activity (GO:2001056)	RO:0002213	cysteine-type endopeptidase activity
GPI-anchor transamidase activity (GO:0003923)	is_a	cysteine-type endopeptidase activity
cysteine-type endopeptidase activity involved in apoptotic process (GO:0097153)	is_a	cysteine-type endopeptidase activity
calcium-dependent cysteine-type endopeptidase activity (GO:0004198)	is_a	cysteine-type endopeptidase activity
cysteine-type endopeptidase activator activity (GO:0140608)	RO:0002629	cysteine-type endopeptidase activity
regulation of cysteine-type endopeptidase activity (GO:2000116)	RO:0002211	cysteine-type endopeptidase activity
negative regulation of cysteine-type endopeptidase activity (GO:2000117)	RO:0002212	cysteine-type endopeptidase activity
ubiquitin-like protein-specific endopeptidase activity (GO:0070137)	is_a	cysteine-type endopeptidase activity

EC: 3.4.22.41; 3.4.22.40; 3.4.22.8; 3.4.22.34; 3.4.22.1; 3.4.22.38; 3.4.22.-; 3.4.22.28; 3.4.22.27; 3.4.22.15; 3.4.22.14; 3.4.22.16
MetaCyc: 3.4.22.1-RXN; 3.4.22.15-RXN; 3.4.22.41-RXN; 3.4.22.34-RXN; 3.4.22.38-RXN; 3.4.22.27-RXN; 3.4.22.14-RXN; 3.4.22.16-RXN; 3.4.22.40-RXN
Reactome: R-HSA-9694601; R-HSA-5357828; R-HSA-211190; R-HSA-1236948; R-HSA-9647999; R-HSA-9694441; R-HSA-9729730; R-HSA-114261; R-HSA-211186; R-HSA-9684352; R-HSA-9684351; R-HSA-9694551; R-HSA-9686930; R-HSA-2130504; R-HSA-2130349; R-HSA-1678920; R-HSA-202917; R-HSA-9647632; R-HSA-351936; R-HSA-212552; R-HSA-139952; R-HSA-351894; R-HSA-114252; R-HSA-9684340; R-HSA-9729704; R-HSA-9603534; R-HSA-5660663; R-HSA-2130336; R-HSA-350158; R-HSA-350319; R-HSA-350318; R-HSA-448703; R-HSA-114259; R-HSA-5681987; R-HSA-418852; R-HSA-9694377; R-HSA-9684336; R-HSA-351877; R-HSA-351876; R-HSA-9686088; R-HSA-351913; R-HSA-201640; R-HSA-139898; R-HSA-351871; R-HSA-264871; R-HSA-1678981; R-HSA-9697750; R-HSA-9684321; R-HSA-9013895; R-HSA-264865; R-HSA-201637; R-HSA-202967; R-HSA-201636; R-HSA-9647680; R-HSA-201639; R-HSA-202969; R-HSA-2028697; R-HSA-351901; R-HSA-202960; R-HSA-418846; R-HSA-201595; R-HSA-418845; R-HSA-201631; R-HSA-201630; R-HSA-2028692; R-HSA-202966; R-HSA-350651; R-HSA-201634; R-HSA-9012556; R-HSA-2130706; R-HSA-933532; R-HSA-351849; R-HSA-5682377; R-HSA-201628; R-HSA-201629; R-HSA-201622; R-HSA-352268; R-HSA-9694625; R-HSA-9684309; R-HSA-5634228; R-HSA-202947; R-HSA-9710101; R-HSA-9684273; R-HSA-2562564; R-HSA-211651; R-HSA-201611; R-HSA-9694732; R-HSA-9694338; R-HSA-3465448; R-HSA-9729741; R-HSA-201603; R-HSA-202939; R-HSA-201608; R-HSA-9693929; R-HSA-6814387