AmiGO 2: Term Details for "intracellularly ATP-gated chloride channel activity" (GO:0005260)

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Term Information

Accession: GO:0005260
Name: intracellularly ATP-gated chloride channel activity
Ontology: molecular_function
Synonyms: CFTR, channel-conductance-controlling ATPase activity, cystic fibrosis transmembrane conductance regulator
Alternate IDs: GO:0005224
Definition: Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. Source: PMID:9922375, PMID:24727426
Comment: This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator).
History: See term history for GO:0005260 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to intracellularly ATP-gated chloride channel activity (excluding "regulates").; Link to all direct and indirect annotations to intracellularly ATP-gated chloride channel activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for intracellularly ATP-gated chloride channel activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0051179 localization
GO:0003674 molecular_function
GO:0006810 transport
GO:0051234 establishment of localization
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0022857 transmembrane transporter activity
GO:0005215 transporter activity
GO:0015267 channel activity
GO:0015698 inorganic anion transport
GO:0098660 inorganic ion transmembrane transport
GO:0006820 monoatomic anion transport
GO:0034220 monoatomic ion transmembrane transport
GO:0022803 passive transmembrane transporter activity
GO:0003824 catalytic activity
GO:0006821 chloride transport
GO:0022836 gated channel activity
GO:0098661 inorganic anion transmembrane transport
GO:0015318 inorganic molecular entity transmembrane transporter activity
GO:0098656 monoatomic anion transmembrane transport
GO:0015075 monoatomic ion transmembrane transporter activity
GO:1902476 chloride transmembrane transport
GO:0015103 inorganic anion transmembrane transporter activity
GO:0016853 isomerase activity
GO:0022834 ligand-gated channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0008509 monoatomic anion transmembrane transporter activity
GO:0005216 monoatomic ion channel activity
GO:0035381 ATP-gated ion channel activity
GO:0015108 chloride transmembrane transporter activity
GO:0005217 intracellularly ligand-gated monoatomic ion channel activity
GO:0120543 macromolecular conformation isomerase activity
GO:0005253 monoatomic anion channel activity
GO:0005254 chloride channel activity
GO:0099142 intracellularly ATP-gated ion channel activity
GO:0099095 ligand-gated monoatomic anion channel activity
GO:0120544 polypeptide conformation or assembly isomerase activity
GO:0005260 intracellularly ATP-gated chloride channel activity

Parents of intracellularly ATP-gated chloride channel activity (GO:0005260)

subject	relation	object
intracellularly ATP-gated chloride channel activity	is_a	intracellularly ATP-gated ion channel activity (GO:0099142)
intracellularly ATP-gated chloride channel activity	is_a	ligand-gated monoatomic anion channel activity (GO:0099095)
intracellularly ATP-gated chloride channel activity	RO:0004009	chloride (CHEBI:17996)
intracellularly ATP-gated chloride channel activity	is_a	chloride channel activity (GO:0005254)
intracellularly ATP-gated chloride channel activity	is_a	polypeptide conformation or assembly isomerase activity (GO:0120544)

This term has no children.

EC: 5.6.1.6
MetaCyc: 3.6.3.49-RXN
TC: 3.A.1.202.1
Wikipedia: Cystic_fibrosis_transmembrane_conductance_regulator