AmiGO 2: Term Details for "JNK cascade" (GO:0007254)

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Term Information

Accession: GO:0007254
Name: JNK cascade
Ontology: biological_process
Synonyms: MAPK8 cascade, c-Jun N-terminal kinase cascade, JNK1 cascade, JNK2 cascade, JNK3 cascade, MAPK10 cascade, MAPK9 cascade, SAPK cascade, stress-activated protein kinase cascade
Alternate IDs: None
Definition: A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation. Source: PMID:11790549, PMID:20811974, PMID:23125017
Comment: None
History: See term history for GO:0007254 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to JNK cascade (excluding "regulates").; Link to all direct and indirect annotations to JNK cascade (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for JNK cascade (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical entity
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0141124 intracellular signaling cassette
GO:0000165 MAPK cascade
GO:0007254 JNK cascade
GO:0004705 JUN kinase activity
GO:0008545 JUN kinase kinase activity
GO:0042656 JUN kinase kinase kinase kinase activity
GO:0007258 JUN phosphorylation
GO:0046329 negative regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0046328 regulation of JNK cascade

Parents of JNK cascade (GO:0007254)

subject	relation	object
JNK cascade	is_a	MAPK cascade (GO:0000165)

Children of JNK cascade (GO:0007254)

subject	relation	object
positive regulation of JNK cascade (GO:0046330)	RO:0002213	JNK cascade
negative regulation of JNK cascade (GO:0046329)	RO:0002212	JNK cascade
JUN phosphorylation (GO:0007258)	BFO:0000050	JNK cascade
JUN kinase kinase kinase kinase activity (GO:0042656)	BFO:0000050	JNK cascade
JUN kinase kinase activity (GO:0008545)	BFO:0000050	JNK cascade
JUN kinase activity (GO:0004705)	BFO:0000050	JNK cascade
regulation of JNK cascade (GO:0046328)	RO:0002211	JNK cascade

JNK cascade