AmiGO 2: Term Details for "vascular endothelial growth factor receptor signaling pathway" (GO:0048010)

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Term Information

Accession: GO:0048010
Name: vascular endothelial growth factor receptor signaling pathway
Ontology: biological_process
Synonyms: VEGF receptor signaling pathway, VEGF receptor signalling pathway, VEGFR signaling pathway
Alternate IDs: None
Definition: The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Source: GOC:signaling, GOC:ceb
Comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
History: See term history for GO:0048010 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to vascular endothelial growth factor receptor signaling pathway (excluding "regulates").; Link to all direct and indirect annotations to vascular endothelial growth factor receptor signaling pathway (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for vascular endothelial growth factor receptor signaling pathway (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007167 enzyme-linked receptor protein signaling pathway
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
GO:0060851 vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
GO:0036323 vascular endothelial growth factor receptor-1 signaling pathway
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway
GO:0036325 vascular endothelial growth factor receptor-3 signaling pathway

Parents of vascular endothelial growth factor receptor signaling pathway (GO:0048010)

subject	relation	object
vascular endothelial growth factor receptor signaling pathway	RO:0002162	Eumetazoa (NCBITaxon:6072)
vascular endothelial growth factor receptor signaling pathway	is_a	cell surface receptor protein tyrosine kinase signaling pathway (GO:0007169)

Children of vascular endothelial growth factor receptor signaling pathway (GO:0048010)

subject	relation	object
vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment (GO:0060851)	is_a	vascular endothelial growth factor receptor signaling pathway
vascular endothelial growth factor receptor-2 signaling pathway (GO:0036324)	is_a	vascular endothelial growth factor receptor signaling pathway
positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)	RO:0002213	vascular endothelial growth factor receptor signaling pathway
vascular endothelial growth factor receptor-1 signaling pathway (GO:0036323)	is_a	vascular endothelial growth factor receptor signaling pathway
negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	RO:0002212	vascular endothelial growth factor receptor signaling pathway
regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)	RO:0002211	vascular endothelial growth factor receptor signaling pathway
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway (GO:0038033)	is_a	vascular endothelial growth factor receptor signaling pathway
vascular endothelial growth factor receptor-3 signaling pathway (GO:0036325)	is_a	vascular endothelial growth factor receptor signaling pathway

Reactome: R-HSA-194138