AmiGO 2: Term Details for "SMAD protein signal transduction" (GO:0060395)

Accession: GO:0060395
Name: SMAD protein signal transduction
Ontology: biological_process
Synonyms: None
Alternate IDs: None
Definition: An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes. Source: GOC:BHF
Comment: Note that the upstream receptor and its ligand regulate the pathway (and are not part of the SMAD pathway), since it is an intracellular signaling pathway.
History: See term history for GO:0060395 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to SMAD protein signal transduction (excluding "regulates").; Link to all direct and indirect annotations to SMAD protein signal transduction (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for SMAD protein signal transduction (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
SMAD protein signal transduction	is_a	intracellular signaling cassette (GO:0141124)
SMAD protein signal transduction	BFO:0000050	cell surface receptor protein serine/threonine kinase signaling pathway (GO:0007178)

subject	relation	object
negative regulation of SMAD protein signal transduction (GO:0060392)	RO:0002212	SMAD protein signal transduction
regulation of SMAD protein signal transduction (GO:0060390)	RO:0002211	SMAD protein signal transduction
positive regulation of SMAD protein signal transduction (GO:0060391)	RO:0002213	SMAD protein signal transduction

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