AmiGO 2: Term Details for "14-3-3 protein binding" (GO:0071889)

Accession: GO:0071889
Name: 14-3-3 protein binding
Ontology: molecular_function
Synonyms: None
Alternate IDs: None
Definition: Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. Source: PMID:15167810, GOC:mah, PMID:19575580, GOC:cna
Comment: None
History: See term history for GO:0071889 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to 14-3-3 protein binding (excluding "regulates").; Link to all direct and indirect annotations to 14-3-3 protein binding (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for 14-3-3 protein binding (excluding "regulates").