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Protein Ontology report - left-right determination factor 2 (human)
PR:O00292 - http://purl.obolibrary.org/obo/PR_O00292
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:O00292   
  PRO nameleft-right determination factor 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hLEFTY2
Gene-based: RELATED:EBAF | LEFTA | LEFTY2 | LEFTYA | PSEC0024 | TGFB4
Other: EXACT:endometrial bleeding-associated factor (human) | left-right determination factor A (human) | protein lefty-2 (human) | protein lefty-A (human) | TGF-beta-4 (human) | transforming growth factor beta-4 (human)
  Definition"A lefty 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00292] 
  PRO Categoryorganism-gene 
  ParentPR:000000288
PR:000029067
  Gene TemplateHGNC:3122 LEFTY2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:O00292
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:O00292 left-right determination factor 2 (human), hLEFTY2

organism-sequence


PR:000000452 lefty 2 sequence variant S342N (human), hLEFTY2/var:S342N
Yes
organism-sequence


PR:O00292-1 left-right determination factor 2 isoform 1 (human), hLEFTY2/iso:1
Yes
organism-modification


PR:000036549 lefty 2 isoform 1 cleaved 1 (human), hLEFTY2/iso:1/Clv:1
Yes
organism-modification


PR:000036550 lefty 2 isoform 1 cleaved 2 (human), hLEFTY2/iso:1/Clv:2
Yes
organism-sequence


PR:O00292-2 left-right determination factor 2 isoform h2 (human), hLEFTY2/iso:h2

organism-modification


PR:000048185 left-right determination factor 2, signal peptide removed form (human), hLEFTY2/SigPep-

organism-modification


PR:000083292 left-right determination factor 2 phosphorylated 1 (human), hLEFTY2/Phos:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000452
hLEFTY2/var:S342N
UniProtKB:O00292, Ser-342, CHEBI:50347 | UniProtKB:O00292-1, Ser-342, CHEBI:50347 | lefty 2 sequence variant 1 (human)		 associated_with_disease_progressionDO:0050545 visceral heterotaxy PMID:10053005
PR:000036549
hLEFTY2/iso:1/Clv:1
UniProtKB:O00292-1, 77-366 | PRO_0000033807		 acts_upstream_of_or_withinGO:0007275 multicellular organism development PMID:10053005
GO:0007309 oocyte axis specification PMID:10053005
located_inGO:0005615 extracellular space PMID:11278322
PR:000036550
hLEFTY2/iso:1/Clv:2
UniProtKB:O00292-1, 135-366		 acts_upstream_of_or_withinGO:0043406 positive regulation of MAP kinase activity PMID:11278322
located_inGO:0005615 extracellular space PMID:11278322
PR:O00292-1
hLEFTY2/iso:1
 acts_upstream_of_or_withinGO:0007275 multicellular organism development PMID:10053005
GO:0007309 oocyte axis specification PMID:10053005