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Protein Ontology report - segment polarity protein dishevelled homolog DVL-2 (human)

PR:O14641 - http://purl.obolibrary.org/obo/PR_O14641

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PAF

GPI

PRO ID

PR:O14641

PRO name

segment polarity protein dishevelled homolog DVL-2 (human)

Synonyms

PRO-Short-label:	EXACT:	hDVL2
Gene-based:	RELATED:	DVL2
Other:	EXACT:	dishevelled-2 (human) \| DSH homolog 2 (human)

Definition

"A segment polarity protein dishevelled homolog DVL-2 that is encoded in the genome of human." [PMID:20823832, PRO:KER]

PRO Category

organism-gene

Parent

PR:000006767 segment polarity protein dishevelled homolog DVL-2
PR:000029067 Homo sapiens protein

Gene Template

HGNC:3086 DVL2 (human)

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	0	Organism-Gene	1
Sequence	0	Organism-Sequence	1
Modification	0	Organism-Modification	7

Term Hierarchy
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DAG:

OLS:

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Related Cross References
Db identifiers	UniProtKB:O14641

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Protein Forms

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Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

organism-gene

PR:O14641 segment polarity protein dishevelled homolog DVL-2 (human), hDVL2

Yes

organism-sequence

PR:O14641-1 segment polarity protein dishevelled homolog DVL-2 isoform 1 (human), hDVL2/iso:1

organism-modification

PR:000035550 segment polarity protein dishevelled homolog DVL-2 unphosphorylated form (human), hDVL2/PhosRes-

Yes

organism-modification

PR:000047225 segment polarity protein dishevelled homolog DVL-2 phosphorylated form (human), hDVL2/PhosRes+

organism-modification

PR:000035549 segment polarity protein dishevelled homolog DVL-2 phosphorylated 1 (human), hDVL2/Phos:1

Yes

organism-modification

PR:000064079 segment polarity protein dishevelled homolog DVL-2 phosphorylated (human), hDVL2/PhosRes(2+)

organism-modification

PR:000047226 segment polarity protein dishevelled homolog DVL-2 ubiquitinated form (human), hDVL2/UbiqLys+

organism-modification

PR:000074434 segment polarity protein dishevelled homolog DVL-2 cysteinylated 1 (human), hDVL2/Cyst:1

organism-modification

PR:000083432 segment polarity protein dishevelled homolog DVL-2 methylated 1 (human), hDVL2/Me:1

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000035549 hDVL2/Phos:1 UniProtKB:O14641, Thr-206, MOD:00047 "A segment polarity protein dishevelled homolog DVL-2 phosphorylated 1 in human. UniProtKB:O14641, Thr-206, MOD:00047." [PMID:20823832, PRO:KER]	acts_upstream_of_or_within	GO:0031577 spindle checkpoint signaling	PMID:20823832
	acts_upstream_of_or_within	increased GO:0051294 establishment of spindle orientation relative to PR:000035550 hDVL2/PhosRes-	PMID:20823832
PR:000035550 hDVL2/PhosRes- "A segment polarity protein dishevelled homolog DVL-2 unphosphorylated form in human." [PMID:20823832, PRO:KER]	acts_upstream_of_or_within	GO:0031577 spindle checkpoint signaling	PMID:20823832
	located_in	GO:0000776 kinetochore	PMID:20823832
PR:O14641 hDVL2 DVL2 \| dishevelled-2 (human) \| DSH homolog 2 (human) "A segment polarity protein dishevelled homolog DVL-2 that is encoded in the genome of human." [PMID:20823832, PRO:KER]	acts_upstream_of_or_within	GO:0008608 attachment of spindle microtubules to kinetochore	PMID:20823832
		GO:0031589 cell-substrate adhesion	PMID:20823832
		GO:0033674 positive regulation of kinase activity	PMID:20823832
		GO:0034501 protein localization to kinetochore	PMID:20823832
		GO:0034501 protein localization to kinetochore	PMID:20823832
		GO:0051310 metaphase chromosome alignment	PMID:20823832
	enables	GO:0005515 protein binding with PR:P25054 APC	PMID:20823832
		GO:0005515 protein binding with PR:P33981 hTTK	PMID:20823832
		GO:0005515 protein binding with PR:P53350 hPLK1	PMID:20823832
	located_in	GO:0000776 kinetochore	PMID:20823832
		GO:0000922 spindle pole	PMID:20823832
		GO:0005819 spindle	PMID:20823832
		GO:0032154 cleavage furrow	PMID:20823832