PRO Term |
GO Annotation |
Evidence |
PR:000000398 hTGFB1/var:L10P UniProtKB:P01137, Leu-10, CHEBI:50342 | TGF-beta 1 sequence variant 1 (human) "A transforming growth factor beta-1 (human) that has a Pro residue at the position equivalent to Leu-10 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Leu-10, CHEBI:50342." [PMID:12202987, PMID:3861940, PMID:9783545, PRO:CNA, PRO:DAN] |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:9783545 |
PR:000000399 hTGFB1/var:T81H UniProtKB:P01137, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 (human) "A transforming growth factor beta-1 (human) that has a His residue at the position equivalent to Tyr-81 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Tyr-81, CHEBI:29979." [PMID:11062463, PMID:12493741, PRO:CNA, PRO:DAN] |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:11062463 |
associated_with_disease_progression | DO:4997 Camurati-Engelmann disease |
PMID:12493741 |
located_in | SO:0001558 polypeptide_localization_variant |
PMID:11062463; PMID:12493741 |
PR:000000400 hTGFB1/var:R218C UniProtKB:P01137, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 (human) "A transforming growth factor beta-1 (human) that has a Cys residue at the position equivalent to Arg-218 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN] |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:12843182 |
GO:0043066 negative regulation of apoptotic process |
PMID:11062463; PMID:12493741; PMID:12843182 |
associated_with_disease_progression | DO:4997 Camurati-Engelmann disease |
PMID:10973241; PMID:11062463; PMID:12493741; PMID:12843182 |
enables | increased GO:0008083 growth factor activity relative to PR:000002555 TGFB1/iso:1/UnMod |
PMID:11062463; PMID:12493741; PMID:12843182 |
PR:000000401 hTGFB1/var:R218H UniProtKB:P01137, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 (human) "A transforming growth factor beta-1 (human) that has a His residue at the position equivalent to Arg-218 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Arg-218, CHEBI:29979." [PMID:11062463, PMID:12493741, PRO:CNA, PRO:DAN] |
associated_with_disease_progression | DO:4997 Camurati-Engelmann disease |
PMID:12493741 |
PR:000000402 hTGFB1/var:H222D UniProtKB:P01137, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 (human) "A transforming growth factor beta-1 (human) that has an Asp residue at the position equivalent to His-222 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, His-222, CHEBI:29958." [PMID:12493741, PRO:CNA, PRO:DAN] |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:12493741 |
GO:0043066 negative regulation of apoptotic process |
PMID:12493741 |
associated_with_disease_progression | DO:4997 Camurati-Engelmann disease |
PMID:12493741 |
PR:000000403 hTGFB1/var:C225R UniProtKB:P01137, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 (human) "A transforming growth factor beta-1 (human) that has an Arg residue at the position equivalent to Cys-225 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Cys-225, CHEBI:29952." [PMID:12493741, PRO:CNA, PRO:DAN] |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:11062463; PMID:12493741; PMID:12843182 |
GO:0043066 negative regulation of apoptotic process |
PMID:11062463; PMID:12493741; PMID:12843182 |
associated_with_disease_progression | DO:4997 Camurati-Engelmann disease |
PMID:12493741 |
enables | increased GO:0008083 growth factor activity relative to PR:000002555 TGFB1/iso:1/UnMod |
PMID:11062463; PMID:12493741; PMID:12843182 |
located_in | GO:0005615 extracellular space |
PMID:11062463; PMID:12493741; PMID:12843182 |
PR:000000619 hTGFB1/var:T81H/Clv:1 UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 cleaved 1 (human) "A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN] |
located_in | SO:0001558 polypeptide_localization_variant |
PMID:12493741 |
PR:000000620 hTGFB1/var:T81H/Clv:2 UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 cleaved 2 (human) "A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN] |
located_in | GO:0005615 extracellular space |
PMID:12493741 |
PR:000000621 hTGFB1/var:R218C/Clv:1 UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 1 (human) "A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950." [PMID:11278244, PRO:CNA, PRO:DAN] |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:11062463; PMID:12493741; PMID:12843182 |
enables | GO:0005160 transforming growth factor beta receptor binding |
PMID:11278244 |
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein |
PMID:11062463; PMID:12493741; PMID:12843182 |
GO:0042803 protein homodimerization activity |
PMID:11062463; PMID:12493741; PMID:12843182 |
located_in | GO:0005615 extracellular space |
PMID:11062463; PMID:12493741; PMID:12843182 |
PR:000000622 hTGFB1/var:R218C/Clv:2 UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 2 (human) "A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN] |
located_in | SO:0001561 polypeptide_partial_loss_of_function |
PMID:11278244 |
PR:000000623 hTGFB1/var:H222D/Clv:1 UniProtKB:P01137, 279-390, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 cleaved 1 (human) "A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958." [PRO:CNA, PRO:DAN] |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:12493741 |
GO:0043066 negative regulation of apoptotic process |
PMID:12493741 |
enables | increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein |
PMID:12493741 |
located_in | GO:0005615 extracellular space |
PMID:12493741 |
PR:000000624 hTGFB1/var:H222D/Clv:2 UniProtKB:P01137, 30-278, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 cleaved 2 (human) "A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, His-222, CHEBI:29958." [PMID:11278244, PRO:CNA, PRO:DAN] |
located_in | SO:0001561 polypeptide_partial_loss_of_function |
PMID:11278244 |
SO:0001601 conformational_change_variant |
PMID:11278244 |
PR:000000625 hTGFB1/var:C225R/Clv:1 UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 cleaved 1 (human) "A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952." [PRO:CNA, PRO:DAN] |
enables | increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein |
PMID:11062463; PMID:12493741; PMID:12843182 |
located_in | GO:0005615 extracellular space |
PMID:11062463; PMID:12493741; PMID:12843182 |
PR:000000626 hTGFB1/var:C225R/Clv:2 UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 cleaved 2 (human) "A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952." [PMID:11278244, PRO:CNA, PRO:DAN] |
located_in | SO:0001561 polypeptide_partial_loss_of_function |
PMID:11278244 |
PR:000000627 hTGFB1/var:R218H/Clv:1 UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 cleaved 1 (human) "A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN] |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:11278244 |
enables | GO:0005160 transforming growth factor beta receptor binding |
PMID:11278244 |
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein |
PMID:12493741; PMID:12843182 |
GO:0042803 protein homodimerization activity |
PMID:11278244 |
located_in | GO:0005615 extracellular space |
PMID:11278244 |
PR:000000628 hTGFB1/var:R218H/Clv:2 UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 cleaved 2 (human) "A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide. UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN] |
located_in | SO:0001561 polypeptide_partial_loss_of_function |
PMID:11278244 |
SO:0001601 conformational_change_variant |
PMID:11278244 |
PR:000025927 hTGFB1/iso:1/mature UniProtKB:P01137-1, 279-390 | PRO_0000033763 "A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913] |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:8471846 |
GO:0043066 negative regulation of apoptotic process |
PMID:9918798 |
enables | GO:0042803 protein homodimerization activity |
PMID:3162913; PMID:8471846 |
located_in | GO:0031012 extracellular matrix |
PMID:8294500 |
PR:000026335 hTGFB1/iso:1/inactive UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160 "A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN] |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:3162913 |
enables | NOT GO:0005160 transforming growth factor beta receptor binding |
PMID:2677679; PMID:3162913 |
GO:0042803 protein homodimerization activity |
PMID:3162913 |
located_in | GO:0031012 extracellular matrix |
PMID:17015622; PMID:8294500 |
GO:0032991 protein-containing complex |
PMID:3162913 |
PR:000036526 hTGFB1/iso:1/LAP UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160 "A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN] |
located_in | GO:0032991 protein-containing complex |
PMID:17015622; PMID:3162913 |
PR:P01137-1 hTGFB1/iso:1
"A TGF-beta 1 isoform 1 that is encoded in the genome of human." [PRO:CNA] |
acts_upstream_of_or_within | GO:0007179 transforming growth factor beta receptor signaling pathway |
PMID:1544940 |
GO:0043066 negative regulation of apoptotic process |
PMID:9918798 |
enables | GO:0042803 protein homodimerization activity |
PMID:1544940 |
located_in | GO:0005796 Golgi lumen |
PMID:1544940 |