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RACE-PRO
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Documentation
Protein Ontology report - tumor necrosis factor (human)
PR:P01375 -
http://purl.obolibrary.org/obo/PR_P01375
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P01375
PRO name
tumor necrosis factor (human)
Synonyms
PRO-Short-label
:
EXACT:
hTNF
Gene-based
:
RELATED:
TNF | TNFA | TNFSF2
Other
:
EXACT:
cachectin (human) | TNF-a (human) | TNF-alpha (human) | TNFa (human) | tumor necrosis factor ligand superfamily member 2 (human)
Definition
"A tumor necrosis factor that is encoded in the genome of human." [PRO:DNx]
Comment
Requested by=PubChem.
PRO Category
organism-gene
Parent
PR:000000134
PR:000029067
Gene Template
HGNC:11892
TNF (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
1
Modification
0
Organism-Modification
5
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P01375
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-gene
PR:P01375
tumor necrosis factor (human), hTNF
Yes
organism-sequence
PR:P01375-1
tumor necrosis factor isoform 1 (human), hTNF/iso:1
Yes
organism-modification
PR:000036504
tumor necrosis factor isoform 1 cleaved 1 (human), hTNF/iso:1/Clv:1
Yes
organism-modification
PR:000036507
tumor necrosis factor isoform 1 myristoylated 1 (human), hTNF/iso:1/Myr:1
Yes
organism-modification
PR:000036508
tumor necrosis factor isoform 1 phosphorylated 1 (human), hTNF/iso:1/Phos:1
Yes
organism-modification
PR:000051774
tumor necrosis factor O-glycosylated 1 (human), hTNF/OGlyco:1
organism-modification
PR:000051775
tumor necrosis factor O-glycosylated 2 (human), hTNF/OGlyco:2
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hTNF
forms found in complexes
hTNF
Component
Complexes
PR:P01375
hTNF
PR:000028432
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036504
hTNF/iso:1/Clv:1
UniProtKB:P01375-1, 77-233 | PRO_0000034424
acts_upstream_of_or_within
GO:0006915
apoptotic process
PMID:3856324
enables
GO:0005164
tumor necrosis factor receptor binding
with
PR:P19438
CD120a (human)
PMID:14512626
GO:0042802
identical protein binding
PMID:14512626
PR:000036507
hTNF/iso:1/Myr:1
UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087
located_in
GO:0016020
membrane
PMID:1402651
PR:000036508
hTNF/iso:1/Phos:1
UniProtKB:P01375-1, Ser-2, MOD:00046
located_in
GO:0016020
membrane
PMID:10205166
PR:P01375-1
hTNF/iso:1
acts_upstream_of_or_within
GO:0006915
apoptotic process
PMID:3856324
located_in
GO:0005886
plasma membrane
PMID:3349526