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Protein Ontology report - RAC-alpha serine/threonine-protein kinase (human)
PR:P31749 - http://purl.obolibrary.org/obo/PR_P31749
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P31749   
  PRO nameRAC-alpha serine/threonine-protein kinase (human) 
  Synonyms
PRO-Short-label: EXACT:hAKT1
Gene-based: RELATED:AKT1 | PKB | RAC
Other: EXACT:PKB alpha (human) | protein kinase B (human) | protein kinase B alpha (human) | proto-oncogene c-Akt (human) | RAC-PK-alpha (human)
  Definition"A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human." [PRO:WCB, UniProtKB:P31749] 
  PRO Categoryorganism-gene 
  ParentPR:000002190 RAC-alpha serine/threonine-protein kinase
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:391 AKT1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P31749
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P31749 RAC-alpha serine/threonine-protein kinase (human), hAKT1

organism-sequence


PR:000061890 RAC-alpha serine/threonine-protein kinase sequence variant E17K (human), hAKT1/var:E17K

organism-sequence


PR:P31749-1 RAC-alpha serine/threonine-protein kinase isoform 1 (human), hAKT1/iso:1

organism-modification


PR:000027473 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human), hAKT1/iso:1/Phos:2
Yes
organism-modification


PR:000028994 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human), hAKT1/iso:1/Phos:1
Yes
organism-sequence


PR:P31749-2 RAC-alpha serine/threonine-protein kinase isoform h2 (human), hAKT1/iso:h2

organism-modification


PR:000046294 RAC-alpha serine/threonine-protein kinase phosphorylated 3 (human), hAKT1/Phos:3

organism-modification


PR:000046295 RAC-alpha serine/threonine-protein kinase phosphorylated 4 (human), hAKT1/Phos:4

organism-modification


PR:000046296 RAC-alpha serine/threonine-protein kinase phosphorylated 1 (human), hAKT1/Phos:1

organism-modification


PR:000046297 RAC-alpha serine/threonine-protein kinase phosphorylated 5 (human), hAKT1/Phos:5

organism-modification


PR:000061529 RAC-alpha serine/threonine-protein kinase sequence variant E17K phosphorylated 1 (human), hAKT1/var:E17K/Phos:1

organism-modification


PR:000061599 RAC-alpha serine/threonine-protein kinase sequence variant E17K phosphorylated 2 (human), hAKT1/var:E17K/Phos:2

organism-modification


PR:000065619 RAC-alpha serine/threonine-protein kinase methylated 1 (human), hAKT1/Me:1

organism-modification


PR:000068716 RAC-alpha serine/threonine-protein kinase phosphorylated 2 (human), hAKT1/Phos:2

organism-modification


PR:000072278 RAC-alpha serine/threonine-protein kinase deaminated 1 (human), hAKT1/Deam:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027473 hAKT1/iso:1/Phos:2
UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046
"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 in human. UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046." [PMID:16549426, PRO:PD]		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:16549426
PR:000028994 hAKT1/iso:1/Phos:1
UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046 | Akt1 active form (human)
"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 in human. UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046." [PMID:8978681, PRO:ALI]		 acts_upstream_of_or_withinGO:0032869 cellular response to insulin stimulus PMID:8978681
GO:0051092 positive regulation of NF-kappaB transcription factor activity PMID:12138205
enablesGO:0004672 protein kinase activity PMID:8978681
GO:0004674 protein serine/threonine kinase activity PMID:12138205
GO:0005515 protein binding PMID:12138205
GO:0005515 protein binding PMID:12138205