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Protein Ontology report - TGF-beta receptor type-1 (human)
PR:P36897 -
http://purl.obolibrary.org/obo/PR_P36897
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P36897
PRO name
TGF-beta receptor type-1 (human)
Synonyms
PRO-Short-label
:
EXACT:
hTGFBR1
Gene-based
:
RELATED:
ALK5 | SKR4 | TGFBR1
Other
:
EXACT:
activin A receptor type II-like protein kinase of 53kD (human) | activin receptor-like kinase 5 (human) | ALK-5 (human) | serine/threonine-protein kinase receptor R4 (human) | TbetaR-I (human) | TGF-beta receptor type I (human) | TGF-beta type I receptor (human) | TGFR-1 (human) | transforming growth factor-beta receptor type I (human)
Definition
"A TGF-beta receptor type-1 that is encoded in the genome of human." [PRO:CNA,
UniProtKB:P36897
]
PRO Category
organism-gene
Parent
PR:000000047
TGF-beta receptor type-1
PR:000029067
Homo sapiens protein
Gene Template
HGNC:11772
TGFBR1 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
14
Modification
0
Organism-Modification
14
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P36897
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-gene
PR:P36897
TGF-beta receptor type-1 (human), hTGFBR1
organism-sequence
PR:000000186
TGF-beta receptor type-1 sequence variant T200I (human), hTGFBR1/var:T200I
Yes
organism-sequence
PR:000000187
TGF-beta receptor type-1 sequence variant 10 (human), hTGFBR1/var:10
Yes
organism-sequence
PR:000000188
TGF-beta receptor type-1 sequence variant 11 (human), hTGFBR1/var:11
Yes
organism-sequence
PR:000000189
TGF-beta receptor type-1 sequence variant K232E (human), hTGFBR1/var:K232E
Yes
organism-sequence
PR:000000190
TGF-beta receptor type-1 sequence variant S241L (human), hTGFBR1/var:S241L
Yes
organism-sequence
PR:000000191
TGF-beta receptor type-1 sequence variant N267H (human), hTGFBR1/var:N267H
Yes
organism-sequence
PR:000000192
TGF-beta receptor type-1 sequence variant M318R (human), hTGFBR1/var:M318R
Yes
organism-sequence
PR:000000193
TGF-beta receptor type-1 sequence variant D400G (human), hTGFBR1/var:D400G
Yes
organism-sequence
PR:000000194
TGF-beta receptor type-1 sequence variant R487P (human), hTGFBR1/var:R487P
Yes
organism-sequence
PR:000000195
TGF-beta receptor type-1 sequence variant R487E (human), hTGFBR1/var:R487E
Yes
organism-sequence
PR:000000196
TGF-beta receptor type-1 sequence variant R487W (human), hTGFBR1/var:R487W
Yes
organism-sequence
PR:P36897-1
TGF-beta receptor type-1 isoform 1 (human), hTGFBR1/iso:1
Yes
organism-modification
PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human), hTGFBR1/iso:1/SigPep-
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human), hTGFBR1/iso:1/SigPep-/Phos:1
Yes
Yes
organism-sequence
PR:P36897-2
TGF-beta receptor type-1 isoform h2 (human), hTGFBR1/iso:h2
organism-sequence
PR:P36897-3
TGF-beta receptor type-1 isoform h3 (human), hTGFBR1/iso:h3
organism-modification
PR:000049432
TGF-beta receptor type-1, signal peptide removed form (human), hTGFBR1/SigPep-
organism-modification
PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human), hTGFBR1/iso:1/SigPep-
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human), hTGFBR1/iso:1/SigPep-/Phos:1
Yes
Yes
organism-modification
PR:000049433
TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human), hTGFBR1/SigPep-/UbiqLys+
organism-modification
PR:000049433
TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human), hTGFBR1/SigPep-/UbiqLys+
organism-modification
PR:000060809
TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human), hTGFBR1/var:G52R/SigPep-
organism-modification
PR:000060890
TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human), hTGFBR1/var:R414*/SigPep-/Phos:1
organism-modification
PR:000061254
TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human), hTGFBR1/var:P83L/SigPep-
organism-modification
PR:000061891
TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human), hTGFBR1/var:P83S/SigPep-
organism-modification
PR:000063489
TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human), hTGFBR1/var:C41Y/SigPep-
organism-modification
PR:000063569
TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human), hTGFBR1/var:N45S/SigPep-
organism-modification
PR:000064307
TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human), hTGFBR1/var:W242*/SigPep-/Phos:1
organism-modification
PR:000067321
TGF-beta receptor type-1 methylated 1 (human), hTGFBR1/Me:1
organism-modification
PR:000070298
TGF-beta receptor type-1 methylated 2 (human), hTGFBR1/Me:2
organism-modification
PR:000075184
TGF-beta receptor type-1 cysteinylated 1 (human), hTGFBR1/Cyst:1
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hTGFBR1
forms found in complexes
hTGFBR1
Component
Complexes
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
PR:000025961
transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000186
hTGFBR1/var:T200I
UniProtKB:P36897, Thr-200, CHEBI:30009 | UniProtKB:P36897-1, Thr-200, CHEBI:30009 | TGF-beta receptor type-1 sequence variant 1 (human)
"A TGF-beta receptor type-1 (human) that has an Ile residue at the position equivalent to Thr-200 of the amino acid sequence represented by UniProtKB:P36897. UniProtKB:P36897, Thr-200, CHEBI:30009." [PMID:15731757, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000187
hTGFBR1/var:10
TGFBR1*10A
"A TGF-beta receptor type-1 (human) that has an insertion of an Ala residue at the position equivalent to Ala-26 of the amino acid sequence represented by UniProtKB:P36897." [PRO:CNA, PRO:DAN]
located_in
SO:0001605
amino_acid_insertion
PMID:9661882
PR:000000188
hTGFBR1/var:11
UniProtKB:P36897, 1-23, 27-503 | UniProtKB:P36897-1, 1-23, 27-503 | TGFBR1*6A (human)
"A TGF-beta receptor type-1 (human) that has a three-residue deletion at the position equivalent to region 24-26 of the amino acid sequence represented by UniProtKB:P36897-1. UniProtKB:P36897, 1-23, 27-503." [PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007165
signal transduction
PMID:9661882
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:9661882
PR:000000189
hTGFBR1/var:K232E
UniProtKB:P36897, Lys-232, CHEBI:29972 | UniProtKB:P36897-1, Lys-232, CHEBI:29972 | TGF-beta receptor type-1 sequence variant 2 (human)
"A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Lys-232 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Lys-232, CHEBI:29972." [PMID:16928994, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:16928994
PR:000000190
hTGFBR1/var:S241L
UniProtKB:P36897, Ser-241, CHEBI:30006 | UniProtKB:P36897-1, Ser-241, CHEBI:30006 | TGF-beta receptor type-1 sequence variant 3 (human)
"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Ser-241, CHEBI:30006." [PMID:16596670, PMID:16791849, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:16596670
;
PMID:16791849
PR:000000191
hTGFBR1/var:N267H
UniProtKB:P36897, Asn-267, CHEBI:29979 | UniProtKB:P36897-1, Asn-267, CHEBI:29979 | TGF-beta receptor type-1 sequence variant 4 (human)
"A TGF-beta receptor type-1 (human) that has a His residue at the position equivalent to Asn-267 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asn-267, CHEBI:29979." [PMID:16791849, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:16791849
PR:000000192
hTGFBR1/var:M318R
UniProtKB:P36897, Met-318, CHEBI:29952 | UniProtKB:P36897-1, Met-318, CHEBI:29952 | TGF-beta receptor type-1 sequence variant 5 (human)
"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Met-318 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Met-318, CHEBI:29952." [PMID:15731757, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000193
hTGFBR1/var:D400G
UniProtKB:P36897, Asp-400, CHEBI:29947 | UniProtKB:P36897-1, Asp-400, CHEBI:29947 | TGF-beta receptor type-1 sequence variant 6 (human)
"A TGF-beta receptor type-1 (human) that has a Gly residue at the position equivalent to Asp-400 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asp-400, CHEBI:29947." [PMID:15731757, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000194
hTGFBR1/var:R487P
UniProtKB:P36897, Arg-487, CHEBI:50342 | UniProtKB:P36897-1, Arg-487, CHEBI:50342 | TGF-beta receptor type-1 sequence variant 7 (human)
"A TGF-beta receptor type-1 (human) that has a Pro residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:50342." [PMID:15731757, PMID:16928994, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14756
vascular type Ehlers-Danlos syndrome
PMID:15731757
;
PMID:16928994
PR:000000195
hTGFBR1/var:R487E
UniProtKB:P36897, Arg-487, CHEBI:29972 | UniProtKB:P36897-1, Arg-487, CHEBI:29972 | TGF-beta receptor type-1 sequence variant 8 (human)
"A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29972." [PMID:16791849, PMID:16928994, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:16791849
;
PMID:16928994
PR:000000196
hTGFBR1/var:R487W
UniProtKB:P36897, Arg-487, CHEBI:29954 | UniProtKB:P36897-1, Arg-487, CHEBI:29954 | TGF-beta receptor type-1 sequence variant 9 (human)
"A TGF-beta receptor type-1 (human) that has a Trp residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29954." [PMID:16928994, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14756
vascular type Ehlers-Danlos syndrome
PMID:16928994
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047 | PRO_0000024423, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. Phosphorylation occurs by the action of active TGF-beta receptor type-2 within the GS-motifs. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
acts_upstream_of_or_within
GO:0006468
protein phosphorylation
PMID:7774578
GO:0007165
signal transduction
PMID:8242743
GO:0007181
transforming growth factor beta receptor complex assembly
PMID:8947046
enables
GO:0005025
transforming growth factor beta receptor activity, type I
PMID:7774578
;
PMID:8947046
located_in
GO:0005886
plasma membrane
PMID:8947046
PR:000036432
hTGFBR1/iso:1/SigPep-
UniProtKB:P36897-1, 34-503
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
acts_upstream_of_or_within
GO:0007165
signal transduction
PMID:8242743
GO:0007181
transforming growth factor beta receptor complex assembly
PMID:8242743
located_in
GO:0005886
plasma membrane
PMID:8242743
PR:P36897-1
hTGFBR1/iso:1
"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
acts_upstream_of_or_within
GO:0007165
signal transduction
PMID:8242743
