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Protein Ontology report - growth/differentiation factor 5 (human)
PR:P43026 - http://purl.obolibrary.org/obo/PR_P43026
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P43026   
  PRO namegrowth/differentiation factor 5 (human) 
  Synonyms
PRO-Short-label: EXACT:hGDF5
Gene-based: RELATED:BMP14 | CDMP1 | GDF5
Other: EXACT:BMP-14 (human) | bone morphogenetic protein 14 (human) | cartilage-derived morphogenetic protein 1 (human) | CDMP-1 (human) | GDF-5 (human) | LAP-4 (human) | lipopolysaccharide-associated protein 4 (human) | LPS-associated protein 4 (human) | radotermin (human)
  Definition"A growth/differentiation factor 5 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P43026
  PRO Categoryorganism-gene 
  ParentPR:000000281
PR:000029067
  Gene TemplateHGNC:4220 GDF5 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P43026
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:P43026 growth/differentiation factor 5 (human), hGDF5


organism-sequence



PR:000000437 growth/differentiation factor 5 sequence variant C400Y (human), hGDF5/var:C400Y

Yes

organism-sequence



PR:000000438 growth/differentiation factor 5 sequence variant R438L (human), hGDF5/var:R438L

Yes

organism-sequence



PR:000000439 growth/differentiation factor 5 sequence variant L441P (human), hGDF5/var:L441P

Yes

organism-sequence



PR:P43026-1 growth/differentiation factor 5 isoform 1 (human), hGDF5/iso:1

Yes

organism-modification



PR:000036543 growth/differentiation factor 5 isoform 1 cleaved 1 (human), hGDF5/iso:1/Clv:1

Yes

organism-modification



PR:000047523 growth/differentiation factor 5, signal peptide removed form (human), hGDF5/SigPep-


organism-modification



PR:000036543 growth/differentiation factor 5 isoform 1 cleaved 1 (human), hGDF5/iso:1/Clv:1

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000437
hGDF5/var:C400Y
UniProtKB:P43026, Cys-400, CHEBI:46858 | growth/differentiation factor 5 sequence variant 1 (human)
associated_with_disease_progressionDO:0080052 acromesomelic dysplasia, Grebe type UniProtKB_VAR:VAR_017407
enablesGO:0005515 protein binding with PR:000000164 BMP-2 PMID:9288098
NOT GO:0008083 growth factor activity PMID:9288098
located_inGO:0005622 intracellular anatomical structure PMID:9288098
PR:000000438
hGDF5/var:R438L
UniProtKB:P43026, Arg-438, CHEBI:30006 | growth/differentiation factor 5 sequence variant 2 (human)
associated_with_disease_progressionDO:0050794 multiple synostoses syndrome PMID:16532400
located_inGO:0005615 extracellular space PMID:16532400
PR:000000439
hGDF5/var:L441P
UniProtKB:P43026, Leu-441, CHEBI:50342 | growth/differentiation factor 5 sequence variant 3 (human)
associated_with_disease_progressionDO:0050790 fibular hypoplasia and complex brachydactyly UniProtKB_VAR:VAR_017408
PR:000036543
hGDF5/iso:1/Clv:1
UniProtKB:P43026-1, 382-501 | PRO_0000033913
enablesGO:0005102 signaling receptor binding PMID:15752764; PMID:15890363
GO:0005515 protein binding PMID:9288098
GO:0008083 growth factor activity PMID:8589725
GO:0042803 protein homodimerization activity PMID:15752764; PMID:8962721
located_inGO:0005615 extracellular space PMID:16532400
PR:P43026-1
hGDF5/iso:1
acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:7961761
GO:0007267 cell-cell signaling PMID:8589725