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Protein Ontology report - tumor necrosis factor ligand superfamily member 6 (human)

PR:P48023 - http://purl.obolibrary.org/obo/PR_P48023

Protein Forms

Annotations

Ontology Information

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PAF

GPI

PRO ID

PR:P48023

PRO name

tumor necrosis factor ligand superfamily member 6 (human)

Synonyms

PRO-Short-label:	EXACT:	hFASLG
Gene-based:	RELATED:	APT1LG1 \| CD95L \| FASL \| FASLG \| TNFSF6
Other:	EXACT:	apoptosis antigen ligand (human) \| APTL (human) \| CD178 (human) \| CD95 ligand (human) \| CD95-L (human) \| Fas antigen ligand (human) \| Fas ligand (human)

Definition

"A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P48023]

PRO Category

organism-gene

Parent

PR:000000095
PR:000029067

Gene Template

HGNC:11936 FASLG (human)

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	0	Organism-Gene	1
Sequence	0	Organism-Sequence	3
Modification	0	Organism-Modification	2

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	UniProtKB:P48023

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Protein Forms

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Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

organism-gene

PR:P48023 tumor necrosis factor ligand superfamily member 6 (human), hFASLG

organism-sequence

PR:P48023-1 tumor necrosis factor ligand superfamily member 6 isoform FasL (human), hFASLG/iso:FasL

Yes

organism-sequence

PR:000036782 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human), hFASLG/iso:FasL/var:F273L

Yes

organism-modification

PR:000036458 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human), hFASLG/iso:FasL/NGlyco:1

Yes

organism-modification

PR:000036459 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human), hFASLG/iso:FasL/Clv:soluble

Yes

organism-sequence

PR:P48023-2 tumor necrosis factor ligand superfamily member 6 isoform h2 (human), hFASLG/iso:h2

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000036458 hFASLG/iso:FasL/NGlyco:1 UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160	acts_upstream_of_or_within	GO:0097190 apoptotic signaling pathway	PMID:9405425
	enables	GO:0005102 signaling receptor binding	PMID:9405425
PR:000036459 hFASLG/iso:FasL/Clv:soluble UniProtKB:P48023-1, 130-281 \| PRO_0000034501	acts_upstream_of_or_within	GO:0043066 negative regulation of apoptotic process	PMID:9396774
	enables	GO:0005102 signaling receptor binding	PMID:9405425
	enables	GO:0042802 identical protein binding	PMID:7536672; PMID:9228058; PMID:9405425
	located_in	GO:0005615 extracellular space	PMID:7536672
PR:000036782 hFASLG/iso:FasL/var:F273L UniProtKB:P48023-1, Phe-275, CHEBI:30006 \| FASLG isoform 1 sequence variant 1 (human) \| FASLG isoform FasL sequence variant 1 (human) \| tumor necrosis factor ligand superfamily member 6 isoform 1 sequence variant 1 (human) \| tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant 1 (human) \| gld	enables	altered GO:0005102 signaling receptor binding with PR:P25445 apo-1 antigen (human)	PMID:9405425
	enables	GO:0042802 identical protein binding	PMID:9405425
	located_in	GO:0009986 cell surface	PMID:9405425
PR:P48023-1 hFASLG/iso:FasL FASLG isoform 1 (human) \| tumor necrosis factor ligand superfamily member 6 isoform 1 (human)	acts_upstream_of_or_within	GO:0043123 positive regulation of canonical NF-kappaB signal transduction	PMID:12761501