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Protein Ontology report - cartilage oligomeric matrix protein (human)
PR:P49747 - http://purl.obolibrary.org/obo/PR_P49747
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P49747   
  PRO namecartilage oligomeric matrix protein (human) 
  Synonyms
PRO-Short-label: EXACT:hCOMP
Gene-based: RELATED:COMP
Other: EXACT:thrombospondin-5 (human) | TSP5 (human)
  Definition"A cartilage oligomeric matrix protein that is encoded in the genome of human." [PRO:CNA, UniProtKB:P49747] 
  PRO Categoryorganism-gene 
  ParentPR:000000085
PR:000029067
  Gene TemplateHGNC:2227 COMP (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 35                                        
         Modification0                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P49747
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P49747 cartilage oligomeric matrix protein (human), hCOMP

organism-sequence


PR:000000231 cartilage oligomeric matrix protein sequence variant P276R (human), hCOMP/var:P276R
Yes
organism-sequence


PR:000000232 cartilage oligomeric matrix protein sequence variant C387G (human), hCOMP/var:C387G
Yes
organism-sequence


PR:000000233 cartilage oligomeric matrix protein sequence variant D408Y (human), hCOMP/var:D408Y
Yes
organism-sequence


PR:000000234 cartilage oligomeric matrix protein sequence variant D420A (human), hCOMP/var:D420A
Yes
organism-sequence


PR:000000235 cartilage oligomeric matrix protein sequence variant G440E (human), hCOMP/var:G440E
Yes
organism-sequence


PR:000000236 cartilage oligomeric matrix protein sequence variant G440R (human), hCOMP/var:G440R
Yes
organism-sequence


PR:000000237 cartilage oligomeric matrix protein sequence variant N453S (human), hCOMP/var:N453S
Yes
organism-sequence


PR:000000238 cartilage oligomeric matrix protein sequence variant D439V (human), hCOMP/var:D439V
Yes
organism-sequence


PR:000000239 cartilage oligomeric matrix protein sequence variant C468Y (human), hCOMP/var:C468Y
Yes
organism-sequence


PR:000000240 cartilage oligomeric matrix protein sequence variant D472Y (human), hCOMP/var:D472Y
Yes
organism-sequence


PR:000000241 cartilage oligomeric matrix protein sequence variant D473G (human), hCOMP/var:D473G
Yes
organism-sequence


PR:000000242 cartilage oligomeric matrix protein sequence variant D290N (human), hCOMP/var:D290N
Yes
organism-sequence


PR:000000243 cartilage oligomeric matrix protein sequence variant D482G (human), hCOMP/var:D482G
Yes
organism-sequence


PR:000000244 cartilage oligomeric matrix protein sequence variant D518N (human), hCOMP/var:D518N
Yes
organism-sequence


PR:000000245 cartilage oligomeric matrix protein sequence variant G719D (human), hCOMP/var:G719D
Yes
organism-sequence


PR:000000246 cartilage oligomeric matrix protein sequence variant N523K (human), hCOMP/var:N523K
Yes
organism-sequence


PR:000000247 cartilage oligomeric matrix protein sequence variant T585M (human), hCOMP/var:T585M
Yes
organism-sequence


PR:000000248 cartilage oligomeric matrix protein sequence variant T585R (human), hCOMP/var:T585R
Yes
organism-sequence


PR:000000249 cartilage oligomeric matrix protein sequence variant 26 (human), hCOMP/var:26
Yes
organism-sequence


PR:000000250 cartilage oligomeric matrix protein sequence variant D372del (human), hCOMP/var:D372del
Yes
organism-sequence


PR:000000251 cartilage oligomeric matrix protein sequence variant D374del (human), hCOMP/var:D374del
Yes
organism-sequence


PR:000000252 cartilage oligomeric matrix protein sequence variant S459del (human), hCOMP/var:S459del
Yes
organism-sequence


PR:000000253 cartilage oligomeric matrix protein sequence variant G299R (human), hCOMP/var:G299R
Yes
organism-sequence


PR:000000254 cartilage oligomeric matrix protein sequence variant D469del (human), hCOMP/var:D469del
Yes
organism-sequence


PR:000000255 cartilage oligomeric matrix protein sequence variant D473del (human), hCOMP/var:D473del
Yes
organism-sequence


PR:000000256 cartilage oligomeric matrix protein sequence variant 32 (human), hCOMP/var:32
Yes
organism-sequence


PR:000000257 cartilage oligomeric matrix protein sequence variant 33 (human), hCOMP/var:33
Yes
organism-sequence


PR:000000258 cartilage oligomeric matrix protein sequence variant C328R (human), hCOMP/var:C328R
Yes
organism-sequence


PR:000000259 cartilage oligomeric matrix protein sequence variant D342Y (human), hCOMP/var:D342Y
Yes
organism-sequence


PR:000000260 cartilage oligomeric matrix protein sequence variant C348R (human), hCOMP/var:C348R
Yes
organism-sequence


PR:000000261 cartilage oligomeric matrix protein sequence variant D361V (human), hCOMP/var:D361V
Yes
organism-sequence


PR:000000262 cartilage oligomeric matrix protein sequence variant D361Y (human), hCOMP/var:D361Y
Yes
organism-sequence


PR:000000263 cartilage oligomeric matrix protein sequence variant C371S (human), hCOMP/var:C371S
Yes
organism-sequence


PR:P49747-1 cartilage oligomeric matrix protein isoform 1 (human), hCOMP/iso:1
Yes
organism-modification


PR:000036452 cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human), hCOMP/iso:1/SigPep-
Yes
organism-sequence


PR:P49747-2 cartilage oligomeric matrix protein isoform h2 (human), hCOMP/iso:h2

organism-modification


PR:000056586 cartilage oligomeric matrix protein N-glycosylated 1 (human), hCOMP/NGlyco:1

organism-modification


PR:000056587 cartilage oligomeric matrix protein N-glycosylated 2 (human), hCOMP/NGlyco:2

organism-modification


PR:000068189 cartilage oligomeric matrix protein deaminated 1 (human), hCOMP/Deam:1

organism-modification


PR:000073868 cartilage oligomeric matrix protein deaminated 2 (human), hCOMP/Deam:2

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000231
hCOMP/var:P276R
UniProtKB:P49747, Pro-276, CHEBI:29952 | UniProtKB:P49747-1, Pro-276, CHEBI:29952 | cartilage oligomeric matrix protein sequence variant 1 (human)		 associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:11565064
PR:000000232
hCOMP/var:C387G
UniProtKB:P49747, Cys-387, CHEBI:29947 | UniProtKB:P49747-1, Cys-387, CHEBI:29947 | cartilage oligomeric matrix protein sequence variant 10 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007625
PR:000000233
hCOMP/var:D408Y
UniProtKB:P49747, Asp-408, CHEBI:46858 | UniProtKB:P49747-1, Asp-408, CHEBI:46858 | cartilage oligomeric matrix protein sequence variant 11 (human)		 associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:9452026
PR:000000234
hCOMP/var:D420A
UniProtKB:P49747, Asp-420, CHEBI:46217 | UniProtKB:P49747-1, Asp-420, CHEBI:46217 | cartilage oligomeric matrix protein sequence variant 12 (human)		 associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:11565064
PR:000000235
hCOMP/var:G440E
UniProtKB:P49747, Gly-440, CHEBI:29972 | UniProtKB:P49747-1, Gly-440, CHEBI:29972 | cartilage oligomeric matrix protein sequence variant 13 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007628
PR:000000236
hCOMP/var:G440R
UniProtKB:P49747, Gly-440, CHEBI:29952 | UniProtKB:P49747-1, Gly-440, CHEBI:29952 | cartilage oligomeric matrix protein sequence variant 14 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:9452026
PR:000000237
hCOMP/var:N453S
UniProtKB:P49747, Asn-453, CHEBI:29999 | UniProtKB:P49747-1, Asn-453, CHEBI:29999 | cartilage oligomeric matrix protein sequence variant 15 (human)		 associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia UniProtKB_VAR:VAR_007630
PR:000000238
hCOMP/var:D439V
UniProtKB:P49747, Asp-439, CHEBI:30015 | UniProtKB:P49747-1, Asp-439, CHEBI:30015 | cartilage oligomeric matrix protein sequence variant 16 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007618
PR:000000239
hCOMP/var:C468Y
UniProtKB:P49747, Cys-468, CHEBI:46858 | UniProtKB:P49747-1, Cys-468, CHEBI:46858 | cartilage oligomeric matrix protein sequence variant 17 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:7670471; PMID:9452026
PR:000000240
hCOMP/var:D472Y
UniProtKB:P49747, Asp-472, CHEBI:46858 | UniProtKB:P49747-1, Asp-472, CHEBI:46858 | cartilage oligomeric matrix protein sequence variant 18 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:7670471; PMID:9452026
PR:000000241
hCOMP/var:D473G
UniProtKB:P49747, Asp-473, CHEBI:29947 | UniProtKB:P49747-1, Asp-473, CHEBI:29947 | cartilage oligomeric matrix protein sequence variant 19 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007635
PR:000000242
hCOMP/var:D290N
UniProtKB:P49747, Asp-290, CHEBI:50347 | UniProtKB:P49747-1, Asp-290, CHEBI:50347 | cartilage oligomeric matrix protein sequence variant 2 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007614
PR:000000243
hCOMP/var:D482G
UniProtKB:P49747, Asp-482, CHEBI:29947 | UniProtKB:P49747-1, Asp-482, CHEBI:29947 | cartilage oligomeric matrix protein sequence variant 20 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:9452063
PR:000000244
hCOMP/var:D518N
UniProtKB:P49747, Asp-518, CHEBI:50347 | UniProtKB:P49747-1, Asp-518, CHEBI:50347 | cartilage oligomeric matrix protein sequence variant 21 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007639
PR:000000245
hCOMP/var:G719D
UniProtKB:P49747, Gly-719, CHEBI:29958 | UniProtKB:P49747-1, Gly-719, CHEBI:29958 | cartilage oligomeric matrix protein sequence variant 22 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:11746044
PR:000000246
hCOMP/var:N523K
UniProtKB:P49747, Asn-523, CHEBI:29967 | UniProtKB:P49747-1, Asn-523, CHEBI:29967 | cartilage oligomeric matrix protein sequence variant 23 (human)		 associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:9021009
PR:000000247
hCOMP/var:T585M
UniProtKB:P49747, Thr-585, CHEBI:16044 | UniProtKB:P49747-1, Thr-585, CHEBI:16044 | cartilage oligomeric matrix protein sequence variant 24 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:11565064
DO:12721 multiple epiphyseal dysplasia PMID:11565064
PR:000000248
hCOMP/var:T585R
UniProtKB:P49747, Thr-585, CHEBI:29952 | UniProtKB:P49747-1, Thr-585, CHEBI:29952 | cartilage oligomeric matrix protein sequence variant 25 (human)		 associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia UniProtKB_VAR:VAR_007642
PR:000000249
hCOMP/var:26
 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007626
PR:000000250
hCOMP/var:D372del
UniProtKB:P49747, 21-371, 373-757 | UniProtKB:P49747-1, 21-371, 373-757 | cartilage oligomeric matrix protein sequence variant 27 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007623
PR:000000251
hCOMP/var:D374del
UniProtKB:P49747, 21-373, 375-757 | UniProtKB:P49747-1, 21-373, 375-757 | cartilage oligomeric matrix protein sequence variant 28 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007624
PR:000000252
hCOMP/var:S459del
UniProtKB:P49747, 21-458, 460-757 | UniProtKB:P49747-1, 21-458, 460-757 | cartilage oligomeric matrix protein sequence variant 29 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007631
PR:000000253
hCOMP/var:G299R
UniProtKB:P49747, Gly-299, CHEBI:29952 | UniProtKB:P49747-1, Gly-299, CHEBI:29952 | cartilage oligomeric matrix protein sequence variant 3 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007615
PR:000000254
hCOMP/var:D469del
UniProtKB:P49747, 21-468, 470-757 | UniProtKB:P49747-1, 21-468, 470-757 | cartilage oligomeric matrix protein sequence variant 30 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007633
PR:000000255
hCOMP/var:D473del
UniProtKB:P49747, 21-472, 474-757 | UniProtKB:P49747-1, 21-472, 474-757 | cartilage oligomeric matrix protein sequence variant 31 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007636
PR:000000256
hCOMP/var:32
UniProtKB:P49747, 21-366, 369-757 | UniProtKB:P49747-1, 21-366, 369-757		 associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia UniProtKB_VAR:VAR_007621
PR:000000257
hCOMP/var:33
UniProtKB:P49747, 21-512, 517-757 | UniProtKB:P49747-1, 21-512, 517-757		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007638
PR:000000258
hCOMP/var:C328R
UniProtKB:P49747, Cys-328, CHEBI:29952 | UniProtKB:P49747-1, Cys-328, CHEBI:29952 | cartilage oligomeric matrix protein sequence variant 4 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007616
PR:000000259
hCOMP/var:D342Y
UniProtKB:P49747, Asp-342, CHEBI:46858 | UniProtKB:P49747-1, Asp-342, CHEBI:46858 | cartilage oligomeric matrix protein sequence variant 5 (human)		 associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:7670472; PMID:9452026
PR:000000260
hCOMP/var:C348R
UniProtKB:P49747, Cys-348, CHEBI:29952 | UniProtKB:P49747-1, Cys-348, CHEBI:29952 | cartilage oligomeric matrix protein sequence variant 6 (human)		 associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:11746045
PR:000000261
hCOMP/var:D361V
UniProtKB:P49747, Asp-361, CHEBI:30015 | UniProtKB:P49747-1, Asp-361, CHEBI:30015 | cartilage oligomeric matrix protein sequence variant 7 (human)		 associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia UniProtKB_VAR:VAR_007619
PR:000000262
hCOMP/var:D361Y
UniProtKB:P49747, Asp-361, CHEBI:46858 | UniProtKB:P49747-1, Asp-361, CHEBI:46858 | cartilage oligomeric matrix protein sequence variant 8 (human)		 associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:9452026
PR:000000263
hCOMP/var:C371S
UniProtKB:P49747, Cys-371, CHEBI:29999 | UniProtKB:P49747-1, Cys-371, CHEBI:29999 | cartilage oligomeric matrix protein sequence variant 9 (human)		 associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:9184241
PR:000036452
hCOMP/iso:1/SigPep-
UniProtKB:P49747-1, 21-757 | PRO_0000035857		 acts_upstream_of_or_withinGO:0009887 animal organ morphogenesis PMID:7713493
enablesGO:0005201 extracellular matrix structural constituent PMID:9749943
GO:0005509 calcium ion binding PMID:7670472
located_inGO:0031012 extracellular matrix PMID:9749943
PR:P49747-1
hCOMP/iso:1
 acts_upstream_of_or_withinGO:0001501 skeletal system development PMID:7670472
GO:0009887 animal organ morphogenesis PMID:7713493