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Protein Ontology report - bone morphogenetic protein receptor type-2 (human)
PR:Q13873 -
http://purl.obolibrary.org/obo/PR_Q13873
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:Q13873
PRO name
bone morphogenetic protein receptor type-2 (human)
Synonyms
PRO-Short-label
:
EXACT:
hBMPR2
Gene-based
:
RELATED:
BMPR2 | PPH1
Other
:
EXACT:
BMP type II receptor (human) | BMP type-2 receptor (human) | BMPR-2 (human) | BMPR-II (human) | bone morphogenetic protein receptor type II (human)
Definition
"A BMP receptor type-2 that is encoded in the genome of human." [PRO:CNA,
UniProtKB:Q13873
]
PRO Category
organism-gene
Parent
PR:000000037
BMP receptor type-2
PR:000029067
Homo sapiens protein
Gene Template
HGNC:1078
BMPR2 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
16
Modification
0
Organism-Modification
7
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:Q13873
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-gene
PR:Q13873
bone morphogenetic protein receptor type-2 (human), hBMPR2
organism-sequence
PR:000000149
BMP receptor type-2 sequence variant C60Y (human), hBMPR2/var:C60Y
Yes
organism-sequence
PR:000000150
BMP receptor type-2 sequence variant D485G (human), hBMPR2/var:D485G
Yes
organism-sequence
PR:000000151
BMP receptor type-2 sequence variant R491Q (human), hBMPR2/var:R491Q
Yes
organism-sequence
PR:000000152
BMP receptor type-2 sequence variant R491W (human), hBMPR2/var:R491W
Yes
organism-sequence
PR:000000153
BMP receptor type-2 sequence variant K512T (human), hBMPR2/var:K512T
Yes
organism-sequence
PR:000000154
BMP receptor type-2 sequence variant N519K (human), hBMPR2/var:N519K
Yes
organism-sequence
PR:000000155
BMP receptor type-2 sequence variant C117Y (human), hBMPR2/var:C117Y
Yes
organism-sequence
PR:000000156
BMP receptor type-2 sequence variant C118W (human), hBMPR2/var:C118W
Yes
organism-sequence
PR:000000157
BMP receptor type-2 sequence variant C123R (human), hBMPR2/var:C123R
Yes
organism-sequence
PR:000000158
BMP receptor type-2 sequence variant C123S (human), hBMPR2/var:C123S
Yes
organism-sequence
PR:000000159
BMP receptor type-2 sequence variant E224D (human), hBMPR2/var:E224D
Yes
organism-sequence
PR:000000160
BMP receptor type-2 sequence variant C347Y (human), hBMPR2/var:C347Y
Yes
organism-sequence
PR:000000161
BMP receptor type-2 sequence variant C420R (human), hBMPR2/var:C420R
Yes
organism-sequence
PR:000000162
BMP receptor type-2 sequence variant C483R (human), hBMPR2/var:C483R
Yes
organism-sequence
PR:Q13873-1
bone morphogenetic protein receptor type-2 isoform 1 (human), hBMPR2/iso:1
Yes
organism-sequence
PR:Q13873-2
bone morphogenetic protein receptor type-2 isoform h2 (human), hBMPR2/iso:h2
organism-modification
PR:000046497
bone morphogenetic protein receptor type-2, signal peptide removed form (human), hBMPR2/SigPep-
organism-modification
PR:000057061
bone morphogenetic protein receptor type-2 N-glycosylated 1 (human), hBMPR2/NGlyco:1
organism-modification
PR:000057062
bone morphogenetic protein receptor type-2 O-glycosylated 1 (human), hBMPR2/OGlyco:1
organism-modification
PR:000065377
bone morphogenetic protein receptor type-2 methylated 1 (human), hBMPR2/Me:1
organism-modification
PR:000065967
bone morphogenetic protein receptor type-2 deaminated 1 (human), hBMPR2/Deam:1
organism-modification
PR:000073289
bone morphogenetic protein receptor type-2 deaminated 2 (human), hBMPR2/Deam:2
organism-modification
PR:000081621
bone morphogenetic protein receptor type-2 deaminated 3 (human), hBMPR2/Deam:3
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000149
hBMPR2/var:C60Y
UniProtKB:Q13873, Cys-60, CHEBI:46858 | UniProtKB:Q13873-1, Cys-60, CHEBI:46858 | BMP receptor type-2 sequence variant 1 (human)
"A bone morphogenetic protein receptor type-2 (human) that has a Tyr residue at the position equivalent to Cys-60 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-60, CHEBI:46858." [PMID:11015450, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:11015450
PR:000000150
hBMPR2/var:D485G
UniProtKB:Q13873, Asp-485, CHEBI:29947 | UniProtKB:Q13873-1, Asp-485, CHEBI:29947 | BMP receptor type-2 sequence variant 10 (human)
"A bone morphogenetic protein receptor type-2 (human) that has a Gly residue at the position equivalent to Asp-485 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Asp-485, CHEBI:29947." [PMID:10973254, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:10973254
PR:000000151
hBMPR2/var:R491Q
UniProtKB:Q13873, Arg-491, CHEBI:30011 | UniProtKB:Q13873-1, Arg-491, CHEBI:30011 | BMP receptor type-2 sequence variant 11 (human)
"A bone morphogenetic protein receptor type-2 (human) that has a Gln residue at the position equivalent to Arg-491 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Arg-491, CHEBI:30011." [PMID:10903931, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:10903931
PR:000000152
hBMPR2/var:R491W
UniProtKB:Q13873, Arg-491, CHEBI:29954 | UniProtKB:Q13873-1, Arg-491, CHEBI:29954 | BMP receptor type-2 sequence variant 12 (human)
"A bone morphogenetic protein receptor type-2 (human) that has a Trp residue at the position equivalent to Arg-491 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Arg-491, CHEBI:29954." [PMID:10903931, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:10903931
PR:000000153
hBMPR2/var:K512T
UniProtKB:Q13873, Lys-512, CHEBI:30013 | UniProtKB:Q13873-1, Lys-512, CHEBI:30013 | BMP receptor type-2 sequence variant 13 (human)
"A bone morphogenetic protein receptor type-2 (human) that has a Thr residue at the position equivalent to Lys-512 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Lys-512, CHEBI:30013." [PMID:11115378, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:11115378
PR:000000154
hBMPR2/var:N519K
UniProtKB:Q13873, Asn-519, CHEBI:29967 | UniProtKB:Q13873-1, Asn-519, CHEBI:29967 | BMP receptor type-2 sequence variant 14 (human)
"A bone morphogenetic protein receptor type-2 (human) that has a Lys residue at the position equivalent to Asn-519 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Asn-519, CHEBI:29967." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
UniProtKB_VAR:VAR_013683
PR:000000155
hBMPR2/var:C117Y
UniProtKB:Q13873, Cys-117, CHEBI:46858 | UniProtKB:Q13873-1, Cys-117, CHEBI:46858 | BMP receptor type-2 sequence variant 2 (human)
"A bone morphogenetic protein receptor type-2 (human) that has a Tyr residue at the position equivalent to Cys-117 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-117, CHEBI:46858." [PMID:11015450, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:11015450
PR:000000156
hBMPR2/var:C118W
UniProtKB:Q13873, Cys-118, CHEBI:29954 | UniProtKB:Q13873-1, Cys-118, CHEBI:29954 | BMP receptor type-2 sequence variant 3 (human)
"A bone morphogenetic protein receptor type-2 (human) that has a Trp residue at the position equivalent to Cys-118 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-118, CHEBI:29954." [PMID:10973254, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:10973254
PR:000000157
hBMPR2/var:C123R
UniProtKB:Q13873, Cys-123, CHEBI:29952 | UniProtKB:Q13873-1, Cys-123, CHEBI:29952 | BMP receptor type-2 sequence variant 4 (human)
"A bone morphogenetic protein receptor type-2 (human) that has an Arg residue at the position equivalent to Cys-123 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-123, CHEBI:29952." [PMID:11115378, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:11115378
PR:000000158
hBMPR2/var:C123S
UniProtKB:Q13873, Cys-123, CHEBI:29999 | UniProtKB:Q13873-1, Cys-123, CHEBI:29999 | BMP receptor type-2 sequence variant 5 (human)
"A bone morphogenetic protein receptor type-2 (human) that has a Ser residue at the position equivalent to Cys-123 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-123, CHEBI:29999." [PMID:11115378, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:11115378
PR:000000159
hBMPR2/var:E224D
UniProtKB:Q13873, Glu-224, CHEBI:29958 | UniProtKB:Q13873-1, Glu-224, CHEBI:29958 | BMP receptor type-2 sequence variant 6 (human)
"A bone morphogenetic protein receptor type-2 (human) that has an Asp residue at the position equivalent to Glu-224 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Glu-224, CHEBI:29958." [PMID:11115378, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:11115378
PR:000000160
hBMPR2/var:C347Y
UniProtKB:Q13873, Cys-347, CHEBI:46858 | UniProtKB:Q13873-1, Cys-347, CHEBI:46858 | BMP receptor type-2 sequence variant 7 (human)
"A bone morphogenetic protein receptor type-2 (human) that has a Tyr residue at the position equivalent to Cys-347 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-347, CHEBI:46858." [PMID:10973254, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:10973254
PR:000000161
hBMPR2/var:C420R
UniProtKB:Q13873, Cys-420, CHEBI:29952 | UniProtKB:Q13873-1, Cys-420, CHEBI:29952 | BMP receptor type-2 sequence variant 8 (human)
"A bone morphogenetic protein receptor type-2 (human) that has an Arg residue at the position equivalent to Cys-420 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-420, CHEBI:29952." [PMID:11115378, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:11115378
PR:000000162
hBMPR2/var:C483R
UniProtKB:Q13873, Cys-483, CHEBI:29952 | UniProtKB:Q13873-1, Cys-483, CHEBI:29952 | BMP receptor type-2 sequence variant 9 (human)
"A bone morphogenetic protein receptor type-2 (human) that has an Arg residue at the position equivalent to Cys-483 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-483, CHEBI:29952." [PMID:11015450, PMID:12358323, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:14557
primary pulmonary hypertension
PMID:11015450
;
PMID:12358323
PR:Q13873-1
hBMPR2/iso:1
"A BMP receptor type-2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
acts_upstream_of_or_within
GO:0007178
transmembrane receptor protein serine/threonine kinase signaling pathway
PMID:7644468
enables
GO:0005515
protein binding
with
PR:P12643
BMP-2 (human)
PMID:7791754
GO:0005515
protein binding
with
PR:P18075
BMP-7 (human)
PMID:7791754
located_in
GO:0005886
plasma membrane
PMID:7791754
GO:0009986
cell surface
PMID:10712517
GO:0043235
receptor complex
PMID:7791754
