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Protein Ontology report - mothers against decapentaplegic homolog 2 (human)
PR:Q15796 - http://purl.obolibrary.org/obo/PR_Q15796
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q15796   
  PRO namemothers against decapentaplegic homolog 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hSMAD2
Gene-based: RELATED:MADH2 | MADR2 | SMAD2
Other: EXACT:hMAD-2 | JV18-1 (human) | MAD homolog 2 (human) | Mad-related protein 2 (human) | mothers against DPP homolog 2 (human) | SMAD 2 (human) | SMAD family member 2 (human) | Smad2 (human)
  Definition"A smad2 that is encoded in the genome of human." [] 
  PRO Categoryorganism-gene 
  ParentPR:000000364
PR:000029067
  Gene TemplateHGNC:6768 SMAD2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 28                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q15796
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:Q15796 mothers against decapentaplegic homolog 2 (human), hSMAD2


organism-sequence



PR:000000470 smad2 sequence variant R133C (human), hSMAD2/var:R133C

Yes

organism-sequence



PR:000000471 smad2 sequence variant L440R (human), hSMAD2/var:L440R

Yes

organism-sequence



PR:000000472 smad2 sequence variant P445H (human), hSMAD2/var:P445H

Yes

organism-sequence



PR:000000473 smad2 sequence variant D450E (human), hSMAD2/var:D450E

Yes

organism-sequence



PR:000000474 smad2 sequence variant 5 (human), hSMAD2/var:5

Yes

organism-sequence



PR:Q15796-1 mothers against decapentaplegic homolog 2 isoform Long (human), hSMAD2/iso:Long


organism-modification



PR:000025934 smad2 isoform Long phosphorylated 1 (human), hSMAD2/iso:Long/Phos:1

Yes

Yes
organism-modification



PR:000025935 smad2 isoform Long phosphorylated 2 (human), hSMAD2/iso:Long/Phos:2

Yes

Yes
organism-modification



PR:000025936 smad2 isoform Long phosphorylated 3 (human), hSMAD2/iso:Long/Phos:3

Yes

Yes
organism-modification



PR:000025937 smad2 isoform Long phosphorylated 4 (human), hSMAD2/iso:Long/Phos:4

Yes

organism-modification



PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human), hSMAD2/iso:Long/AcPhos:1

Yes

organism-modification



PR:000045371 smad2 isoform Long unphosphorylated 1 (human), hSMAD2/iso:Long/UnPhos:1

Yes

Yes
organism-sequence



PR:Q15796-2 mothers against decapentaplegic homolog 2 isoform Short (human), hSMAD2/iso:Short


organism-modification



PR:000025938 smad2 isoform Short phosphorylated 1 (human), hSMAD2/iso:Short/Phos:1

Yes

Yes
organism-modification



PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human), hSMAD2/iso:Short/AcPhos:1

Yes

organism-modification



PR:000045494 smad2 isoform Short unphosphorylated 1 (human), hSMAD2/iso:Short/UnPhos:1


organism-modification



PR:000025960 smad2 isoform unphosphorylated 1 (human), hSMAD2/iso:[Long/Short]/UnPhos:1


organism-modification



PR:000045371 smad2 isoform Long unphosphorylated 1 (human), hSMAD2/iso:Long/UnPhos:1


organism-modification



PR:000045494 smad2 isoform Short unphosphorylated 1 (human), hSMAD2/iso:Short/UnPhos:1


organism-modification



PR:000049281 mothers against decapentaplegic homolog 2, initiator methionine removed form (human), hSMAD2/InitMet-


organism-modification



PR:000049282 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 1 (human), hSMAD2/InitMet-/Phos:1


organism-modification



PR:000049283 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 5 (human), hSMAD2/InitMet-/Phos:5


organism-modification



PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human), hSMAD2/InitMet-/UbiqLys+


organism-modification



PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human), hSMAD2/InitMet-/UbiqLys+


organism-modification



PR:000050145 smad2 phosphorylated 1 (human), hSMAD2/Phos:1


organism-modification



PR:000060357 mothers against decapentaplegic homolog 2 sequence variant D300A, initiator methionine removed phosphorylated 1 (human), hSMAD2/var:D300A/InitMet-/Phos:1


organism-modification



PR:000060522 mothers against decapentaplegic homolog 2 sequence variant S464L, initiator methionine removed form (human), hSMAD2/var:S464L/InitMet-


organism-modification



PR:000060657 mothers against decapentaplegic homolog 2 sequence variant D300V, initiator methionine removed phosphorylated 1 (human), hSMAD2/var:D300V/InitMet-/Phos:1


organism-modification



PR:000060862 mothers against decapentaplegic homolog 2 sequence variant D300N, initiator methionine removed phosphorylated 1 (human), hSMAD2/var:D300N/InitMet-/Phos:1


organism-modification



PR:000061944 mothers against decapentaplegic homolog 2 sequence variant A354T, initiator methionine removed phosphorylated 1 (human), hSMAD2/var:A354T/InitMet-/Phos:1


organism-modification



PR:000062120 mothers against decapentaplegic homolog 2 sequence variant P305Q, initiator methionine removed phosphorylated 1 (human), hSMAD2/var:P305Q/InitMet-/Phos:1


organism-modification



PR:000062419 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 2 (human), hSMAD2/InitMet-/Phos:2


organism-modification



PR:000063661 mothers against decapentaplegic homolog 2 sequence variant S464*, initiator methionine removed form (human), hSMAD2/var:S464*/InitMet-


organism-modification



PR:000063912 mothers against decapentaplegic homolog 2 sequence variant S467P, initiator methionine removed form (human), hSMAD2/var:S467P/InitMet-


organism-modification



PR:000064349 mothers against decapentaplegic homolog 2 sequence variant P305L, initiator methionine removed phosphorylated 1 (human), hSMAD2/var:P305L/InitMet-/Phos:1


organism-modification



PR:000064775 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human), hSMAD2/InitMet-/PhosUbiq:1


organism-modification



PR:000065797 mothers against decapentaplegic homolog 2 methylated 1 (human), hSMAD2/Me:1


organism-modification



PR:000077056 mothers against decapentaplegic homolog 2 cysteinylated 1 (human), hSMAD2/Cyst:1


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hSMAD2 forms found in complexes   

hSMAD2 Component
Complexes
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025933^P000025951
PR:000025935 hSMAD2/iso:Long/Phos:2 PR:000025946
PR:000025936 hSMAD2/iso:Long/Phos:3 PR:000025947
PR:000025938 hSMAD2/iso:Short/Phos:1 PR:000025940
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025952^P000025965
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000470
hSMAD2/var:R133C
UniProtKB:Q15796, Arg-133, CHEBI:29950 | UniProtKB:Q15796-1, Arg-133, CHEBI:29950 | smad2 sequence variant 1 (human)
acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8752209
associated_with_disease_progressionDO:5672 large intestine cancer PMID:8752209
enablesNOT GO:0003713 transcription coactivator activity PMID:8752209
PR:000000471
hSMAD2/var:L440R
UniProtKB:Q15796, Leu-440, CHEBI:29952 | UniProtKB:Q15796-1, Leu-440, CHEBI:29952 | smad2 sequence variant 2 (human)
associated_with_disease_progressionDO:5672 large intestine cancer PMID:8752209
PR:000000472
hSMAD2/var:P445H
UniProtKB:Q15796, Pro-445, CHEBI:29979 | UniProtKB:Q15796-1, Pro-445, CHEBI:29979 | smad2 sequence variant 3 (human)
associated_with_disease_progressionDO:5672 large intestine cancer PMID:8752209
enablesNOT GO:0003713 transcription coactivator activity PMID:8752209
PR:000000473
hSMAD2/var:D450E
UniProtKB:Q15796, Asp-450, CHEBI:29972 | UniProtKB:Q15796-1, Asp-450, CHEBI:29972 | smad2 sequence variant 4 (human)
associated_with_disease_progressionDO:5672 large intestine cancer PMID:8752209
enablesNOT GO:0003713 transcription coactivator activity PMID:8752209
PR:000000474
hSMAD2/var:5
UniProtKB:Q15796, 2-343, 359-467 | UniProtKB:Q15796-1, 2-343, 359-467
associated_with_disease_progressionDO:5672 large intestine cancer PMID:8673135
enablesNOT GO:0003713 transcription coactivator activity PMID:8673135
PR:000025934
hSMAD2/iso:Long/Phos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046
acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:15690394; PMID:9689110
GO:0007165 signal transduction PMID:8752209; PMID:8980228; PMID:9346966
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209; PMID:8980228
GO:0060395 SMAD protein signal transduction PMID:9346966
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8980228; PMID:9346966
GO:0003713 transcription coactivator activity PMID:9689110
GO:0046332 SMAD binding PMID:9311995
located_inGO:0005634 nucleus PMID:9006934; PMID:9346966
PR:000025935
hSMAD2/iso:Long/Phos:2
UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:12193595
GO:0007165 signal transduction PMID:12193595
GO:0060395 SMAD protein signal transduction PMID:12193595
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:12193595
GO:0003712 transcription coregulator activity PMID:12193595
GO:0046332 SMAD binding PMID:12193595
located_inGO:0005634 nucleus PMID:12193595; PMID:17074053
PR:000025936
hSMAD2/iso:Long/Phos:3
UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046
acts_upstream_of_or_withinGO:0007165 signal transduction PMID:11027280
GO:0060395 SMAD protein signal transduction PMID:11027280
enablesNOT GO:0003713 transcription coactivator activity PMID:11027280
GO:0046332 SMAD binding PMID:11027280
located_inGO:0005737 cytoplasm PMID:11027280
PR:000025937
hSMAD2/iso:Long/Phos:4
UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046
enablesNOT GO:0003713 transcription coactivator activity PMID:10197981
located_inGO:0005737 cytoplasm PMID:10197981
PR:000025938
hSMAD2/iso:Short/Phos:1
UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046
acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:9873005
enablesGO:0003677 DNA binding PMID:14701940; PMID:9873005
GO:0003700 DNA-binding transcription factor activity PMID:9873005
GO:0003712 transcription coregulator activity PMID:14701940; PMID:9873005
PR:000036554
hSMAD2/iso:Long/AcPhos:1
UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046
acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:17074756
GO:0007165 signal transduction PMID:17074756
located_inGO:0005634 nucleus PMID:17074756
PR:000036556
hSMAD2/iso:Short/AcPhos:1
UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046
acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
enablesGO:0003677 DNA binding PMID:17074756
increased GO:0003700 DNA-binding transcription factor activity relative to PR:000000656 SMAD2/iso:Short/Phos:1 PMID:17074756
PR:000045371
hSMAD2/iso:Long/UnPhos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291
acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209
enablesGO:0005515 protein binding PMID:8980228
located_inGO:0005737 cytoplasm PMID:15280432; PMID:17074053
GO:0005769 early endosome PMID:12356868