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Protein Ontology report - E3 ubiquitin-protein ligase SIAH1 (human)
PR:Q8IUQ4 -
http://purl.obolibrary.org/obo/PR_Q8IUQ4
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:Q8IUQ4
PRO name
E3 ubiquitin-protein ligase SIAH1 (human)
Synonyms
PRO-Short-label
:
EXACT:
hSIAH1
Gene-based
:
RELATED:
HUMSIAH | SIAH1
Other
:
EXACT:
RING-type E3 ubiquitin transferase SIAH1 (human) | seven in absentia homolog 1 (human) | Siah-1 (human) | Siah-1a (human)
Definition
"An E3 ubiquitin-protein ligase SIAH1 that is encoded in the genome of human." [PRO:DNx,
UniProtKB:Q8IUQ4
]
PRO Category
organism-gene
Parent
PR:000014860
PR:000029067
Gene Template
HGNC:10857
SIAH1 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
3
Modification
0
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:Q8IUQ4
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-gene
PR:Q8IUQ4
E3 ubiquitin-protein ligase SIAH1 (human), hSIAH1
organism-sequence
PR:Q8IUQ4-1
E3 ubiquitin-protein ligase SIAH1 isoform 1 (human), hSIAH1/iso:1
organism-modification
PR:000025641
E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 (human), hSIAH1/iso:1/Phos:1
Yes
organism-modification
PR:000045369
E3 ubiquitin-protein ligase SIAH1 isoform 1 unphosphorylated 1 (human), hSIAH1/iso:1/UnPhos:1
Yes
organism-sequence
PR:Q8IUQ4-2
E3 ubiquitin-protein ligase SIAH1 isoform h2 (human), hSIAH1/iso:h2
organism-sequence
PR:Q8IUQ4-3
E3 ubiquitin-protein ligase SIAH1 isoform h3 (human), hSIAH1/iso:h3
organism-modification
PR:000069106
E3 ubiquitin-protein ligase SIAH1 deaminated 1 (human), hSIAH1/Deam:1
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000025641
hSIAH1/iso:1/Phos:1
UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048
acts_upstream_of_or_within
GO:0043525
positive regulation of neuron apoptotic process
PMID:16230351
GO:0070304
positive regulation of stress-activated protein kinase signaling cascade
PMID:16230351
enables
increased
GO:0005515
protein binding
with
PR:Q69ZI1-1
PMID:16230351
PR:000045369
hSIAH1/iso:1/UnPhos:1
UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, PR:000026291
acts_upstream_of_or_within
GO:0043525
positive regulation of neuron apoptotic process
PMID:16230351
GO:0070304
positive regulation of stress-activated protein kinase signaling cascade
PMID:16230351
enables
GO:0005515
protein binding
with
PR:Q69ZI1
Kiaa1494
PMID:16230351