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Protein Ontology report - E3 ubiquitin-protein ligase SIAH1 (human)
PR:Q8IUQ4 - http://purl.obolibrary.org/obo/PR_Q8IUQ4
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q8IUQ4   
  PRO nameE3 ubiquitin-protein ligase SIAH1 (human) 
  Synonyms
PRO-Short-label: EXACT:hSIAH1
Gene-based: RELATED:HUMSIAH | SIAH1
Other: EXACT:RING-type E3 ubiquitin transferase SIAH1 (human) | seven in absentia homolog 1 (human) | Siah-1 (human) | Siah-1a (human)
  Definition"An E3 ubiquitin-protein ligase SIAH1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8IUQ4] 
  PRO Categoryorganism-gene 
  ParentPR:000014860
PR:000029067
  Gene TemplateHGNC:10857 SIAH1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q8IUQ4
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q8IUQ4 E3 ubiquitin-protein ligase SIAH1 (human), hSIAH1

organism-sequence


PR:Q8IUQ4-1 E3 ubiquitin-protein ligase SIAH1 isoform 1 (human), hSIAH1/iso:1

organism-modification


PR:000025641 E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 (human), hSIAH1/iso:1/Phos:1
Yes
organism-modification


PR:000045369 E3 ubiquitin-protein ligase SIAH1 isoform 1 unphosphorylated 1 (human), hSIAH1/iso:1/UnPhos:1
Yes
organism-sequence


PR:Q8IUQ4-2 E3 ubiquitin-protein ligase SIAH1 isoform h2 (human), hSIAH1/iso:h2

organism-sequence


PR:Q8IUQ4-3 E3 ubiquitin-protein ligase SIAH1 isoform h3 (human), hSIAH1/iso:h3

organism-modification


PR:000069106 E3 ubiquitin-protein ligase SIAH1 deaminated 1 (human), hSIAH1/Deam:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025641
hSIAH1/iso:1/Phos:1
UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048		 acts_upstream_of_or_withinGO:0043525 positive regulation of neuron apoptotic process PMID:16230351
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade PMID:16230351
enablesincreased GO:0005515 protein binding with PR:Q69ZI1-1 PMID:16230351
PR:000045369
hSIAH1/iso:1/UnPhos:1
UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, PR:000026291		 acts_upstream_of_or_withinGO:0043525 positive regulation of neuron apoptotic process PMID:16230351
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade PMID:16230351
enablesGO:0005515 protein binding with PR:Q69ZI1 Kiaa1494 PMID:16230351