PRO Term |
GO Annotation |
Evidence |
PR:000035661 hAURKB/PhosRes-
"An aurora kinase B unphosphorylated form in human." [PMID:22024163, PRO:KER] |
enables | GO:0005515 protein binding with PR:Q9NQS7 hINCENP |
PMID:22024163 |
located_in | GO:0000776 kinetochore |
PMID:22024163 |
PR:000035663 hAURKB/Phos:1 UniProtKB:Q96GD4, Ser-331, MOD:00046 | hAURKB active form "An aurora kinase B phosphorylated 1 in human. This phosphorylated form is present during prometaphase, metaphase, and loss of tension on kinetochores (taxol). UniProtKB:Q96GD4, Ser-331, MOD:00046." [PMID:17276342, PMID:22024163, PMID:23321637, PRO:CNA, PRO:KER] |
acts_upstream_of_or_within | increased GO:0007059 chromosome segregation relative to PR:000035661 hAURKB/PhosRes- |
PMID:22024163 |
increased GO:0031577 spindle checkpoint signaling relative to PR:000035661 hAURKB/PhosRes- |
PMID:22024163 |
increased GO:0051310 metaphase chromosome alignment relative to PR:000035661 hAURKB/PhosRes- |
PMID:22024163 |
enables | increased GO:0004672 protein kinase activity relative to PR:000035661 hAURKB/PhosRes- |
PMID:17276342; PMID:22024163 |
GO:0005515 protein binding |
PMID:22024163 |
located_in | GO:0000776 kinetochore |
PMID:22024163 |
PR:Q96GD4 hAURKB AIK2 | AIM1 | AIRK2 | ARK2 | AURKB | STK1 | STK12 | STK5 | AIM-1 (human) | ARK-2 (human) | aurora 1 (human) | aurora- and IPL1-like midbody-associated protein 1 (human) | aurora-related kinase 2 (human) | aurora/IPL1-related kinase 2 (human) | serine/threonine-protein kinase 12 (human) | serine/threonine-protein kinase 5 (human) | serine/threonine-protein kinase aurora-B (human) | STK-1 (human) (BROAD) "An aurora kinase B that is encoded in the genome of human." [PMID:12719470, PMID:15592459, PMID:15917996, PMID:17617734, PMID:20624902, PMID:21658950, PMID:22732840, PRO:KER] |
acts_upstream_of_or_within | GO:0007059 chromosome segregation |
PMID:12719470 |
GO:0008608 attachment of spindle microtubules to kinetochore |
PMID:12719470; PMID:15592459 |
GO:0031577 spindle checkpoint signaling |
PMID:12719470 |
GO:0034501 protein localization to kinetochore |
PMID:12719470; PMID:17617734; PMID:22732840 |
NOT GO:0051306 mitotic sister chromatid separation |
PMID:12719470 |
GO:0051310 metaphase chromosome alignment |
PMID:12719470; PMID:22732840 |
GO:0071459 protein localization to chromosome, centromeric region |
PMID:12719470; PMID:21658950 |
GO:0140014 mitotic nuclear division |
PMID:12719470 |
enables | GO:0004672 protein kinase activity |
PMID:12719470 |
GO:0005515 protein binding with PR:O60566 BUB1B |
BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928 |
GO:0005515 protein binding with PR:P06493 CDC2 |
BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928 |
GO:0005515 protein binding with PR:P68431 H3C1 |
BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928 |
GO:0005515 protein binding with PR:Q12834 CDC20 |
BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928 |
GO:0005515 protein binding with PR:Q13043 hSTK4 |
BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928 |
GO:0005515 protein binding with PR:Q15208 hSTK38 |
BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928 |
GO:0005515 protein binding with PR:Q53HL2 CDCA8 |
BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928 |
GO:0005515 protein binding with PR:Q71DI3 H3-clustered histone 13 (human) |
BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928 |
GO:0005515 protein binding with PR:Q9NQS7 hINCENP |
BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928 |
GO:0005515 protein binding |
BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928 |
located_in | GO:0000776 kinetochore |
PMID:20624902 |
GO:0000779 condensed chromosome, centromeric region |
PMID:12719470; PMID:15917996 |
GO:0000939 inner kinetochore |
PMID:15592459 |
GO:0030496 midbody |
PMID:15917996 |
GO:0051233 spindle midzone |
PMID:15917996 |