PRO Term |
GO Annotation |
Evidence |
PR:000000759 hHCN4/var:D553N UniProtKB:Q9Y3Q4, Asp-553, CHEBI:50347 | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 1 (human) "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human) that has an Asn residue at the position equivalent to Asp-553 of the amino acid sequence represented by UniProtKB:Q9Y3Q4. UniProtKB:Q9Y3Q4, Asp-553, CHEBI:50347." [PMID:15123648, PRO:CNA, PRO:DAN] |
associated_with_disease_progression | DO:13884 sick sinus syndrome |
PMID:15123648 |
located_in | NOT GO:0005886 plasma membrane |
PMID:15123648 |
PR:000000760 hHCN4/var:S672R UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952 | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 2 (human) "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human) that has an Arg residue at the position equivalent to Ser-672 of the amino acid sequence represented by UniProtKB:Q9Y3Q4. UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952." [PMID:16407510, PRO:CNA, PRO:DAN] |
associated_with_disease_progression | DO:13884 sick sinus syndrome |
PMID:16407510 |
enables | GO:0005222 intracellular cAMP-activated cation channel activity |
PMID:16407510 |
altered GO:0022843 voltage-gated monoatomic cation channel activity relative to PR:000002604 HCN4/iso:1/UnMod |
PMID:16407510 |
PR:Q9Y3Q4-1 hHCN4/iso:1
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 that is encoded in the genome of human." [PRO:CNA] |
acts_upstream_of_or_within | GO:0006812 monoatomic cation transport |
PMID:10228147 |
GO:0006936 muscle contraction |
PMID:10228147 |
enables | GO:0005261 monoatomic cation channel activity |
PMID:10228147 |