cv2obo 13:02:2024 09:12 antibiotic_resistance 1.2 CARD definition database_cross_reference has_exact_synonym has_obo_format_version has_obo_namespace has_synonym_type shorthand RO:0002312 antibiotic_resistance evolutionary_variant_of evolutionary_variant_of evolutionary_variant_of RO:0012006 antibiotic_resistance is_small_molecule_inhibitor is_small_molecule_inhibitor is_small_molecule_inhibitor RO:regulates antibiotic_resistance regulates regulates regulates RO:confers_resistance_to_antibiotic antibiotic_resistance confers_resistance_to_antibiotic confers_resistance_to_antibiotic confers_resistance_to_antibiotic RO:confers_resistance_to_drug_class antibiotic_resistance confers_resistance_to_drug_class confers_resistance_to_drug_class confers_resistance_to_drug_class RO:derives_from antibiotic_resistance derives_from derives_from derives_from RO:has_part antibiotic_resistance has_part has_part has_part RO:part_of antibiotic_resistance part_of part_of part_of RO:participates_in antibiotic_resistance participates_in participates_in participates_in RO:targeted_by antibiotic_resistance targeted_by targeted_by targeted_by RO:targeted_by_antibiotic antibiotic_resistance targeted_by_antibiotic targeted_by_antibiotic targeted_by_antibiotic Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins. antibiotic_resistance ARO:0000000 macrolide antibiotic Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins. PMID:11324679 PMID:15544496 PMID:27480866 The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death. fluoroquinolone quinolone antibiotic_resistance ARO:0000001 fluoroquinolone antibiotic The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death. PMID:23010009 PMID:3311572 PMID:3802748 A family of proteins known to bind to the 30S ribosomal subunit. This interaction prevents tetracycline and tetracycline derivatives from inhibiting ribosomal function. Thus, these proteins confer elevated resistance to tetracycline derivatives as a ribosomal protection protein. antibiotic_resistance ARO:0000002 tetracycline-resistant ribosomal protection protein Astromicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Astromicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. pubchem.compound:5284517 Astromicina Astromicine Astromicinum fortimicin A antibiotic_resistance ARO:0000003 astromicin Astromicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Astromicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. antibiotic_resistance ARO:0000004 monobactam Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. PMID:02669628 PMID:11585791 PMID:15673804 PMID:3871589 Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. pubchem.compound:8378 Fradiomycin Fradiomycinum Framycetinum Mycifradin Neomas Soframycin framycetin neomycin B antibiotic_resistance ARO:0000005 neomycin Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited. pubchem.compound:12560 Abomacetin Emgel Eritromicina Erymax Erythrocin Erythromycin A Erythromycine Erythromycinum N-methylerythromycin A antibiotic_resistance ARO:0000006 erythromycin Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited. PMID:10582867 PMID:15980346 PMID:7683018 Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. pubchem.compound:470999 Debecacin Dibekacina Dibekacine Dibekacinum Dideoxykanamycin B Icacine Kappati Orbicin Panamicin antibiotic_resistance ARO:0000007 dibekacin Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases. pubchem.compound:441199 FOX Mefoxitin mefoxin antibiotic_resistance ARO:0000008 cefoxitin Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases. PMID:11585791 PMID:15673804 PMID:3487346 Tunicamycin is mixture of homologous nucleoside antibiotics that block the reaction of UDP-N-acetylglucosamine and dolichyl phosphate in the first step of glycoprotein synthesis. pubchem.compound:5354023 antibiotic_resistance ARO:0000009 tunicamycin Tunicamycin is mixture of homologous nucleoside antibiotics that block the reaction of UDP-N-acetylglucosamine and dolichyl phosphate in the first step of glycoprotein synthesis. PMID:1624425 Clusters of antibiotic resistance genes. May be regulated by a shared promoter or repressor. antibiotic_resistance ARO:0000010 antibiotic resistance gene cluster, cassette, or operon Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. pubchem.compound:6098 Chloroxacillin Clossacillina Cloxacilina Cloxacilline Cloxacillinum Cloxapen Methocillin S Orbenin Syntarpen Tegopen antibiotic_resistance ARO:0000011 cloxacillin Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. PMID:11585791 PMID:1234495 PMID:15673804 Streptothricins are a group of N-glycoside antibiotics that include a carbamoylated D-glucosamine to which are attached a series of L-beta-lysine residues at position 2 and a streptolidine at position 1. Streptothricins vary by the number of beta-lysine residues (from 1 (nourseothricin) to 7) and target protein synthesis in bacteria and eukaryotes. pubchem.compound:475825 nourseothricin racemomycin streptothricin F yazumycin antibiotic_resistance ARO:0000012 streptothricin Streptothricins are a group of N-glycoside antibiotics that include a carbamoylated D-glucosamine to which are attached a series of L-beta-lysine residues at position 2 and a streptolidine at position 1. Streptothricins vary by the number of beta-lysine residues (from 1 (nourseothricin) to 7) and target protein synthesis in bacteria and eukaryotes. PMID:10103173 PMID:11083623 PMID:8385262 Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. pubchem.compound:37768 AMK Amicacin Amikacina Amikacinum Amikavet Arikace Kaminax Lukadin Mikavir amikacine mikacin antibiotic_resistance ARO:0000013 amikacin Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. pubchem.compound:3084091 Cidomycin Garamycin Gentacycol Gentamicins Gentamycinum Gentavet Gentocin Refobacin Uromycine antibiotic_resistance ARO:0000014 gentamicin C Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Derived from penicillin to combat penicillin-resistance, methicillin is insensitive to beta-lactamases (also known as penicillinases) secreted by many penicillin-resistant bacteria. Methicillin is bactericidal, and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. pubchem.compound:6087 Dimocillin Metacillin Methicillinum Methycillin Meticilina Meticilline Meticillinum Staphcillin meticillin antibiotic_resistance ARO:0000015 methicillin Derived from penicillin to combat penicillin-resistance, methicillin is insensitive to beta-lactamases (also known as penicillinases) secreted by many penicillin-resistant bacteria. Methicillin is bactericidal, and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. PMID:11585791 PMID:15673804 PMID:3889939 Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth. antibiotic_resistance ARO:0000016 aminoglycoside antibiotic Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides. lincosamide antibiotic_resistance ARO:0000017 lincosamide antibiotic Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides. PMID:10582867 PMID:15135500 Viomycin sulfate (Viocin) is an polypeptide antibiotic used in the treatment of tuberculosis. It is produced by the actinomycete Streptomyces puniceus and binds to the bacterial ribosome, inhibiting prokaryotic protein synthesis and certain forms of RNA splicing. pubchem.compound:135398671 Celiomycin Florimycin Tuberactinomycin B Viocin antibiotic_resistance ARO:0000018 viomycin Viomycin sulfate (Viocin) is an polypeptide antibiotic used in the treatment of tuberculosis. It is produced by the actinomycete Streptomyces puniceus and binds to the bacterial ribosome, inhibiting prokaryotic protein synthesis and certain forms of RNA splicing. PMID:211438 Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. antibiotic_resistance ARO:0000020 carbapenem Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. PMID:11585791 PMID:15673804 Ribostamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Ribostamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. pubchem.compound:33042 dekamycin IV hetangmycin ribastamin vistamycin xylostatin antibiotic_resistance ARO:0000021 ribostamycin Ribostamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Ribostamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Polymyxins are cationic detergent antibiotics, with a general structure of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins have a bactericidal effect on Gram-negative bacilli, especially on Pseudomonas and coliform organisms. antibiotic_resistance ARO:0000022 polymyxin antibiotic Polymyxins are cationic detergent antibiotics, with a general structure of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins have a bactericidal effect on Gram-negative bacilli, especially on Pseudomonas and coliform organisms. PMID:11706007 Enoxacin belongs to a group called fluoroquinolones. Its mode of action depends upon blocking bacterial DNA replication by binding itself to DNA gyrase and causing double-stranded breaks in the bacterial chromosome. pubchem.compound:3229 Enroxil Penetrex antibiotic_resistance ARO:0000023 enoxacin Enoxacin belongs to a group called fluoroquinolones. Its mode of action depends upon blocking bacterial DNA replication by binding itself to DNA gyrase and causing double-stranded breaks in the bacterial chromosome. PMID:15914491 Butirosin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Butirosin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. pubchem.compound:72393 ambutyrosin sulfate butirosin sulphate antibiotic_resistance ARO:0000024 butirosin Butirosin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Butirosin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. pubchem.compound:73491 (1R,2S)-1,2-epoxy-propylphosphonic acid phosphomycin phosphonomycin antibiotic_resistance ARO:0000025 fosfomycin Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. PMID:17567049 PMID:18701452 PMID:5809587 PMID:8075064 PMID:8994972 Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30. antibiotic_resistance ARO:0000026 streptogramin antibiotic Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30. PMID:15700955 Roxithromycin is a semi-synthetic, 14-carbon ring macrolide antibiotic derived from erythromycin. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited. pubchem.compound:6915744 antibiotic_resistance ARO:0000027 roxithromycin Roxithromycin is a semi-synthetic, 14-carbon ring macrolide antibiotic derived from erythromycin. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited. PMID:10582867 PMID:15980346 Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria. Vancomycin inhibits the synthesis of peptidoglycan, the major component of the cell wall of gram-positive bacteria. Its mechanism of action is unusual in that it acts by binding precursors of peptidoglycan, rather than by interacting with an enzyme. pubchem.compound:14969 Vancocin antibiotic_resistance ARO:0000028 vancomycin Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria. Vancomycin inhibits the synthesis of peptidoglycan, the major component of the cell wall of gram-positive bacteria. Its mechanism of action is unusual in that it acts by binding precursors of peptidoglycan, rather than by interacting with an enzyme. PMID:16323116 Teicoplanin is a glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria. Teicoplanin has a unique acyl-aliphatic chain, and binds to cell wall precursors to inhibit transglycosylation and transpeptidation. pubchem.compound:16129712 targocid teichomycin antibiotic_resistance ARO:0000029 teicoplanin Teicoplanin is a glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria. Teicoplanin has a unique acyl-aliphatic chain, and binds to cell wall precursors to inhibit transglycosylation and transpeptidation. PMID:11131961 PMID:16323116 PMID:6235205 PMID:6239854 PMID:6240963 Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome. pubchem.compound:54686904 Tygacil antibiotic_resistance ARO:0000030 tigecycline Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome. PMID:11381101 PMID:19862477 Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes. antibiotic_resistance ARO:0000031 antibiotic resistant gene variant or mutant Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. antibiotic_resistance ARO:0000032 cephalosporin Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. PMID:11585791 PMID:15673804 PMID:6810737 Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. antibiotic_resistance ARO:0000034 streptogramin A antibiotic Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. PMID:12102603 PMID:12860128 PMID:15700955 PMID:17015629 Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. pubchem.compound:36119 antibiotic 6640 dehydrogentamicin rickamicin sisomycin sissomicin antibiotic_resistance ARO:0000035 sisomicin Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome. pubchem.compound:2764 CIP Cipro Ciprobay Ciproxan antibiotic_resistance ARO:0000036 ciprofloxacin Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome. PMID:15700957 PMID:15914491 Apramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections in animals. Apramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. pubchem.compound:3081545 ambylan apralan nebramycin II antibiotic_resistance ARO:0000037 apramycin Apramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections in animals. Apramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. pubchem.compound:441306 1-N-aethylsisomicin netilyn netromycin vectacin antibiotic_resistance ARO:0000038 netilmicin Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. PMID:10103173 PMID:11083623 PMID:8385262 Spectinomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Spectinomycin works by binding to the bacterial 30S ribosomal subunit inhibiting translation. pubchem.compound:15541 Actinospectacin Spectam Togamycin Trobicin antibiotic_resistance ARO:0000039 spectinomycin Spectinomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Spectinomycin works by binding to the bacterial 30S ribosomal subunit inhibiting translation. PMID:10103173 PMID:11083623 PMID:8385262 Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. pubchem.compound:19649 streptomycin A streptomycin A sulfate streptomycin sulfate streptomycin sulphate antibiotic_resistance ARO:0000040 streptomycin Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Bacitracin interferes with the dephosphorylation of the C55-isoprenyl pyrophosphate, a molecule which carries the building blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. pubchem.compound:57402735 Altracin Ayfivin BACiiM Baciguent Baciquent Citracin Fortracin Penitracin Topitracin Zutracin antibiotic_resistance ARO:0000041 bacitracin Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Bacitracin interferes with the dephosphorylation of the C55-isoprenyl pyrophosphate, a molecule which carries the building blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. PMID:8389741 Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA. antibiotic_resistance ARO:0000042 glycylcycline Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA. PMID:11381101 Carbenicillin is a semi-synthetic antibiotic belonging to the carboxypenicillin subgroup of the penicillins. It has gram-negative coverage which includes Pseudomonas aeruginosa but limited gram-positive coverage. The carboxypenicillins are susceptible to degradation by beta-lactamase enzymes. Carbenicillin antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. pubchem.compound:20824 Anabactyl CAR Carbecin Carbenicilina Carbenicillina Carbenicilline Carbenicillinum Geopen Microcillin Pyopen antibiotic_resistance ARO:0000043 carbenicillin Carbenicillin is a semi-synthetic antibiotic belonging to the carboxypenicillin subgroup of the penicillins. It has gram-negative coverage which includes Pseudomonas aeruginosa but limited gram-positive coverage. The carboxypenicillins are susceptible to degradation by beta-lactamase enzymes. Carbenicillin antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. PMID:11585791 PMID:15673804 PMID:4248289 Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases. pubchem.compound:123731 antibiotic_resistance ARO:0000044 cephamycin Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases. PMID:11585791 PMID:15673804 PMID:3487346 Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish. pubchem.compound:443101 Acriflavin Assiflavine Bialflavina Bioacridin Bovoflavin Buroflavin Choliflavin Euflavine Pantonsiletten Xanthacridinum antibiotic_resistance ARO:0000045 acriflavine Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish. PMID:11566977 Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction. pubchem.compound:3000540 Cillimycin Epilincomycin Jiemycin Lincocin Lincolcina Lincolnensin Lincomicina Lincomycin A Lincomycine Lincomycinum antibiotic_resistance ARO:0000046 lincomycin Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction. PMID:10582867 PMID:15135500 Puromycin is an aminonucleoside antibiotic, derived from Streptomyces alboniger, that causes premature chain termination during ribosomal protein translation. pubchem.compound:439530 Puromycin dihydrochloride Puromycin hydrochloride Stylomycin dihydrochloride antibiotic_resistance ARO:0000047 puromycin Puromycin is an aminonucleoside antibiotic, derived from Streptomyces alboniger, that causes premature chain termination during ribosomal protein translation. PMID:7608059 Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. pubchem.compound:6032 Aminodeoxykanamycin Aspidium Kanamicina Kanamycin sulfate Kanamycine Kanamycinum Kantrex kanamycin antibiotic_resistance ARO:0000049 kanamycin A Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. antibiotic_resistance ARO:0000050 streptogramin B antibiotic Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. PMID:10582867 PMID:15700955 PMID:9746015 Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome. pubchem.compound:54675776 Abricycline Achromycin Agromicina Ambramicina Ambramycin Biocycline Criseociclina Enterocycline Sumycin Tsiklomistsin antibiotic_resistance ARO:0000051 tetracycline Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome. PMID:11381101 PMID:19862477 Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. pubchem.compound:36294 Gotabiotic Nebcin Tenebrimycin Tobracin Tobradistin Tobramaxin Tobramicin Tobramitsetin Tobramycetin Tobrex antibiotic_resistance ARO:0000052 tobramycin Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Bleomycin is a family of glycopeptide antibiotics produced by the bacterium Streptomyces verticillus. Bleomycins, taken as a mixture, act by the induction of DNA and RNA strand breaks. In addition to its antibacterial activity, bleomycin is also used as an anticancer agent. pubchem.compound:5360373 Blenoxane Bleocin Bleomicin Bleomycin sulfate Isobleomycin A2 cu-blenoxane antibiotic_resistance ARO:0000053 bleomycin Bleomycin is a family of glycopeptide antibiotics produced by the bacterium Streptomyces verticillus. Bleomycins, taken as a mixture, act by the induction of DNA and RNA strand breaks. In addition to its antibacterial activity, bleomycin is also used as an anticancer agent. PMID:15700963 Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. pubchem.compound:2349 Benzopenicillin Cilopen Dropcillin Gelacillin Liquacillin PCN Pharmacillin Pradupen Specilline G penicillin g antibiotic_resistance ARO:0000054 penicillin Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. PMID:11585791 PMID:15673804 Bicyclomycin represents a unique class of antibiotics, discovered in 1972. It is obtained by the fermentation of Streptomyces sapporonensis. In the crystalline form bicyclomycin is observed to be rhombic or monoclinic, depending on the solvent used. This antibiotic kills bacteria by inhibiting the Rho transcription terminator factor, halting ribonucleic acid (RNA) synthesis. pubchem.compound:65807 Aizumycin Bacfeed Bacteron Bicozamicina Bicozamycin Bicozamycine Bicozamycinum antibiotic_resistance ARO:0000055 bicyclomycin Bicyclomycin represents a unique class of antibiotics, discovered in 1972. It is obtained by the fermentation of Streptomyces sapporonensis. In the crystalline form bicyclomycin is observed to be rhombic or monoclinic, depending on the solvent used. This antibiotic kills bacteria by inhibiting the Rho transcription terminator factor, halting ribonucleic acid (RNA) synthesis. PMID:16181146 PMID:7487110 Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. pubchem.compound:6196 MPI-penicillin Ossacillina Oxacilina Oxacilline Oxacillinum Oxazocillin Oxazocilline Prostaphlin Prostaphlyn antibiotic_resistance ARO:0000056 oxacillin Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. PMID:7928809 Telithromycin is a semi-synthetic derivative of erythromycin. It is a 14-membered macrolide and is the first ketolide antibiotic to be used in clinics. Telithromycin binds the 50S subunit of the bacterial ribosome to inhibit protein synthesis. pubchem.compound:3002190 HMR-3647 HMR3647 Ketek Levviax antibiotic_resistance ARO:0000057 telithromycin Telithromycin is a semi-synthetic derivative of erythromycin. It is a 14-membered macrolide and is the first ketolide antibiotic to be used in clinics. Telithromycin binds the 50S subunit of the bacterial ribosome to inhibit protein synthesis. PMID:15700954 Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. pubchem.compound:33255 CFZ Cefamezin Cefazolina Cefazoline Cefazolinum Cephamezine Cephazolidin Cephazolin Cephazoline Elzogram antibiotic_resistance ARO:0000058 cefazolin Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. PMID:27572414 PMID:4790605 Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents. pubchem.compound:5479537 Axepim Cefepima Cefepimum FEP Maxipime antibiotic_resistance ARO:0000059 cefepime Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents. PMID:8150771 Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections. pubchem.compound:5481173 CAZ Ceftazidim Ceptaz Fortaz Pentacef Tazicef Tazidime caftazidime ceftazidima ceftazidimum antibiotic_resistance ARO:0000060 ceftazidime Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections. PMID:6805421 Ceftobiprole (Zeftera/Zevtera) is a next generation (5th generation) cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and Enterococci. Ceftobiprole inhibits transpeptidases essential to building cell walls, and is a poor substrate for most beta-lactamases. pubchem.compound:135413542 Ceftobiprole medocaril Zeftera Zevtera antibiotic_resistance ARO:0000061 ceftobiprole Ceftobiprole (Zeftera/Zevtera) is a next generation (5th generation) cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and Enterococci. Ceftobiprole inhibits transpeptidases essential to building cell walls, and is a poor substrate for most beta-lactamases. PMID:22064544 Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. pubchem.compound:5479530 Biotrakson CRO Cefatriaxone Ceftriaxon Ceftriaxona Ceftriaxonum Ceftriazone Longacef Longaceph Rocephin antibiotic_resistance ARO:0000062 ceftriaxone Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. PMID:6810737 Cefuroxime is a second-generation cephalosporin antibiotic with increased stability with beta-lactamases than first-generation cephalosporins. Cefuroxime is active against Gram-positive organisms but less active against methicillin-resistant strains. pubchem.compound:5479529 Biofuroksym CXM Cefuril Cefuroxim Cefuroximo Cefuroximum Cephuroxime Sharox Zinacef antibiotic_resistance ARO:0000063 cefuroxime Cefuroxime is a second-generation cephalosporin antibiotic with increased stability with beta-lactamases than first-generation cephalosporins. Cefuroxime is active against Gram-positive organisms but less active against methicillin-resistant strains. PMID:1259408 Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan. pubchem.compound:33613 AMX Amolin Amopenixin Amoxicilina Amoxicilline Amoxicillinum Amoxycillin Clamoxyl D-Amoxicillin Moxal antibiotic_resistance ARO:0000064 amoxicillin Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan. PMID:19236222 Clarithromycin is a methyl derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome and is used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), and skin structure infections. pubchem.compound:84029 Biaxin CLR Clambiotic Clarith Clathromycin Klacid Klaricid Macladin Naxy Veclam antibiotic_resistance ARO:0000065 clarithromycin Clarithromycin is a methyl derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome and is used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), and skin structure infections. PMID:7683018 Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria. pubchem.compound:446598 CLI Chlolincocin Chlorlincocin Cleocin Clindamicina Clindamycine Clindamycinum Clinimycin Sobelin antibiotic_resistance ARO:0000066 clindamycin Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria. PMID:20876128 Colistins are polymyxin antibiotics produced by certain strains of Bacillus polymyxa var. colistinus. Colistin, also referred to as polymyxin E, is a mixture of cyclic polypeptides colistin A and B which disrupt the bacterial cell membrane and is effective against Gram-negative bacteria. CST Colomycin polymyxin E antibiotic_resistance ARO:0000067 colistin Colistins are polymyxin antibiotics produced by certain strains of Bacillus polymyxa var. colistinus. Colistin, also referred to as polymyxin E, is a mixture of cyclic polypeptides colistin A and B which disrupt the bacterial cell membrane and is effective against Gram-negative bacteria. PMID:17958555 PMID:20818945 Daptomycin is a novel lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. Daptomycin interferes with the bacterial cell membrane, reducing membrane potential and inhibiting cell wall synthesis. pubchem.compound:16134395 Cidecin Cubicin Daptomicina Daptomycine Daptomycinum Deptomycin antibiotic_resistance ARO:0000068 daptomycin Daptomycin is a novel lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. Daptomycin interferes with the bacterial cell membrane, reducing membrane potential and inhibiting cell wall synthesis. PMID:11353654 PMID:12615866 PMID:14985278 PMID:15870461 PMID:16311632 PMID:20522545 PMID:22083474 Doxycycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome. pubchem.compound:54671203 Azudoxat Deoxymykoin Doxiciclina Doxitard Doxycyclinum Doxytetracycline Vibramycin Vibramycine Vibravenos antibiotic_resistance ARO:0000069 doxycycline Doxycycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome. PMID:11381101 PMID:19862477 Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis. pubchem.compound:150610 Invanz antibiotic_resistance ARO:0000070 ertapenem Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis. PMID:12951340 PMID:27572414 Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Its main target is topoisomerase IV, inhibiting its function and disrupting DNA replication. pubchem.compound:149096 Levaquin Tavanic antibiotic_resistance ARO:0000071 levofloxacin Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Its main target is topoisomerase IV, inhibiting its function and disrupting DNA replication. PMID:15700957 Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. It inhibits protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. pubchem.compound:441401 Zyvox Zyvoxa Zyvoxam Zyvoxid antibiotic_resistance ARO:0000072 linezolid Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. It inhibits protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. PMID:15700955 PMID:18757750 Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem. pubchem.compound:441130 Meronem Meropen Meropenem anhydrous Meropenemum Merrem antibiotic_resistance ARO:0000073 meropenem Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem. PMID:18416587 Moxifloxacin is a fourth generation synthetic fluoroquinolone chemotherapeutic agent, and has been shown to be significantly more active than levofloxacin (4 to 8 times more) against Streptococcus pneumoniae. It acts by inhibiting bacterial DNA topoisomerases. pubchem.compound:152946 Actira (hydrochloride) Avelox Avelox (hydrochloride) MXFX Moxifloxacin hydrochloride Vigamox antibiotic_resistance ARO:0000074 moxifloxacin Moxifloxacin is a fourth generation synthetic fluoroquinolone chemotherapeutic agent, and has been shown to be significantly more active than levofloxacin (4 to 8 times more) against Streptococcus pneumoniae. It acts by inhibiting bacterial DNA topoisomerases. PMID:10193688 PMID:11858629 Nitrofurantoin is an antibiotic used to treat urinary tract infections. It inhibits enzyme synthesis by inhibiting essential enzymes involved in the citric acid cycle, as well as those involved in DNA, RNA, and protein synthesis. It is marketed under the following brand names: Furadantin, Macrobid, Macrodantin, Nitro Macro and Urantoin. pubchem.compound:6604200 Chemiofuran Cistofuran Furadantin Furadantine Furalan Macrobid Macrodantin Macrodantina Nitrofuradantin antibiotic_resistance ARO:0000075 nitrofurantoin Nitrofurantoin is an antibiotic used to treat urinary tract infections. It inhibits enzyme synthesis by inhibiting essential enzymes involved in the citric acid cycle, as well as those involved in DNA, RNA, and protein synthesis. It is marketed under the following brand names: Furadantin, Macrobid, Macrodantin, Nitro Macro and Urantoin. PMID:1100114 PMID:7928834 Resistance-modifying agents (RMA) include antibiotic adjuvants and other inhibitors of antibiotic resistance, as well as antibiotic potentiators. These are non-antibiotic compounds which act to block resistance mechanisms or enhance antibiotic action. These are often delivered in combination with an antibiotic (e.g. amoxicillin-clavulanic acid) and may either affect the host organism or the pathogen. Adjuvants and potentiators are therefore used to rescue the activity of existing antibiotic drugs, and are researched as an alternative solution to the antibiotic resistance crisis. antibiotic_resistance ARO:0000076 resistance-modifying agents Tazobactam is a compound which inhibits the action of bacterial beta-lactamases. pubchem.compound:123630 Zosyn antibiotic_resistance ARO:0000077 tazobactam Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria. pubchem.compound:43672 Piperacillin anhydrous Piperacillin sodium Pipercillin Pipracil Pipril antibiotic_resistance ARO:0000078 piperacillin Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria. PMID:11735679 Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins. pubchem.compound:5280980 Acide clavulanique Acido clavulanico Clavulansaeure Clavulox Isoclavulanic acid Sodium Clavulanate acidum clavulanicum clavulanate antibiotic_resistance ARO:0000079 clavulanic acid Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance. antibiotic_resistance ARO:0001001 antibiotic target alteration Replacement or substitution of antibiotic action target, which process will result in antibiotic resistance. antibiotic target substitution antibiotic_resistance ARO:0001002 antibiotic target replacement Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance. antibiotic_resistance ARO:0001003 antibiotic target protection Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance. PMID:32587401 Enzymatic inactivation of antibiotic to confer drug resistance. drug enzymatic inactivation drug enzymatic modification antibiotic_resistance ARO:0001004 antibiotic inactivation Enzymatic inactivation of antibiotic to confer drug resistance. PMID:20564281 Antibiotic resistance via the transport of antibiotics out of the cell. antibiotic_resistance ARO:0010000 antibiotic efflux Antibiotic resistance via the transport of antibiotics out of the cell. PMID:19678712 Directed pumping of antibiotic out of a cell to confer resistance. ATP-binding cassette (ABC) transporters are present in all cells of all organisms and use the energy of ATP binding/hydrolysis to transport substrates across cell membranes. ABC type drug efflux antibiotic_resistance ARO:0010001 ATP-binding cassette (ABC) antibiotic efflux pump Directed pumping of antibiotic out of a cell to confer resistance. ATP-binding cassette (ABC) transporters are present in all cells of all organisms and use the energy of ATP binding/hydrolysis to transport substrates across cell membranes. PMID:8302219 Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient. MFS type drug efflux antibiotic_resistance ARO:0010002 major facilitator superfamily (MFS) antibiotic efflux pump Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient. PMID:10943556 PMID:19678712 PMID:9529885 Directed pumping of antibiotic out of a cell to confer resistance. Small multidrug resistance (SMR) proteins are a relatively small family of transporters, restricted to prokaryotic cells. They are also the smallest multidrug transporters, with only four transmembrane alpha-helices and no significant extramembrane domain. SMR type drug efflux antibiotic_resistance ARO:0010003 small multidrug resistance (SMR) antibiotic efflux pump Directed pumping of antibiotic out of a cell to confer resistance. Small multidrug resistance (SMR) proteins are a relatively small family of transporters, restricted to prokaryotic cells. They are also the smallest multidrug transporters, with only four transmembrane alpha-helices and no significant extramembrane domain. PMID:17942072 Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient. RND type drug efflux antibiotic_resistance ARO:0010004 resistance-nodulation-cell division (RND) antibiotic efflux pump Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient. PMID:15582398 PMID:16915237 PMID:19664953 Antibiotic resistance is the ability of a microorganism to withstand the effects of an antibiotic. It is a specific type of drug resistance. antibiotic_resistance ARO:1000001 process or component of antibiotic biology or chemistry Antibiotic resistance mechanisms evolve naturally via natural selection through random mutation, but it could also be engineered by applying an evolutionary stress on a population. antibiotic_resistance ARO:1000002 mechanism of antibiotic resistance Antibiotics are commonly classified based on their mechanism of action, chemical structure or spectrum of activity. antibiotic_resistance ARO:1000003 antibiotic molecule A mutation, single nucleotide polymorphism, gene, or gene product that confers antibiotic resistance. antibiotic_resistance ARO:3000000 determinant of antibiotic resistance A mutation, single nucleotide polymorphism, gene, or gene product that confers antibiotic resistance. PMID:15700955 Beta-lactamases are enzymes (EC 3.5.2.6) produced by some bacteria and are responsible for their resistance to beta-lactam antibiotics like penicillins, cephalosporins (are relatively resistant to beta-lactamase), cephamycins, and carbapenems (ertapenem). These antibiotics have a common element in their molecular structure: a four-atom ring known as a beta-lactam. The lactamase enzyme breaks that ring open, deactivating the molecule's antibacterial properties. Beta-lactam antibiotics are typically used to treat a broad spectrum of gram-positive and gram-negative bacteria. Beta-lactamases produced by gram-negative organisms are usually secreted. antibiotic_resistance ARO:3000001 beta-lactamase Beta-lactamases are enzymes (EC 3.5.2.6) produced by some bacteria and are responsible for their resistance to beta-lactam antibiotics like penicillins, cephalosporins (are relatively resistant to beta-lactamase), cephamycins, and carbapenems (ertapenem). These antibiotics have a common element in their molecular structure: a four-atom ring known as a beta-lactam. The lactamase enzyme breaks that ring open, deactivating the molecule's antibacterial properties. Beta-lactam antibiotics are typically used to treat a broad spectrum of gram-positive and gram-negative bacteria. Beta-lactamases produced by gram-negative organisms are usually secreted. PMID:19995920 PMID:21220461 PMID:6109327 PMID:7574506 vanW is an accessory gene, with unknown function, found on vancomycin resistance operons. antibiotic_resistance ARO:3000002 vanW vanW is an accessory gene, with unknown function, found on vancomycin resistance operons. PMID:11036060 These compounds are antibiotics of unique structure or origin, without a defined classification. miscellaneous antibiotic antibiotic_resistance ARO:3000003 antibiotic without defined classification Ambler Class B beta-lactamases are the metallo-beta-lactamases. These enzymes possess one or two zinc ions in the active site, which are used to orient a hydroxide nucleophile to attack the carbonyl on a beta-lactam ring. There are currently no inhibitors in late-stage development for these relatively new beta-lactamases. Molecular Class B beta-lactamase antibiotic_resistance ARO:3000004 class B (metallo-) beta-lactamase Ambler Class B beta-lactamases are the metallo-beta-lactamases. These enzymes possess one or two zinc ions in the active site, which are used to orient a hydroxide nucleophile to attack the carbonyl on a beta-lactam ring. There are currently no inhibitors in late-stage development for these relatively new beta-lactamases. PMID:14629034 PMID:15215079 VanD is a D-Ala-D-Ala ligase homolog similar to VanA, and can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. vanD antibiotic_resistance ARO:3000005 vanD VanD is a D-Ala-D-Ala ligase homolog similar to VanA, and can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. PMID:10368136 vanD VanH is a D-specific alpha-ketoacid dehydrogenase that synthesizes D-lactate. D-lactate is incorporated into the end of the peptidoglycan subunits, decreasing vancomycin binding affinity. antibiotic_resistance ARO:3000006 vanH VanH is a D-specific alpha-ketoacid dehydrogenase that synthesizes D-lactate. D-lactate is incorporated into the end of the peptidoglycan subunits, decreasing vancomycin binding affinity. PMID:1931965 PMID:9177243 Beta-lactam antibiotics are a broad class of antibiotics that include penams (penicillin derivatives), cephems (cephalosporins), monobactams, and carbapenems. These antibiotic agents contain a beta-lactam nucleus in its molecular structure. They are the most widely-used group of antibiotics. antibiotic_resistance ARO:3000007 beta-lactam antibiotic Beta-lactam antibiotics are a broad class of antibiotics that include penams (penicillin derivatives), cephems (cephalosporins), monobactams, and carbapenems. These antibiotic agents contain a beta-lactam nucleus in its molecular structure. They are the most widely-used group of antibiotics. PMID:3889939 Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. antibiotic_resistance ARO:3000008 penam Penams are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. This is the most defining feature of penicillins. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. PMID:3889939 VanA is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It has been isolated from VREs. It is associated with both vancomycin and teicoplanin resistance. PDB:1E4E vanA antibiotic_resistance ARO:3000010 vanA VanA is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It has been isolated from VREs. It is associated with both vancomycin and teicoplanin resistance. PMID:9177243 vanA VanX is a D,D-dipeptidase that cleaves D-Ala-D-Ala but not D-Ala-D-Lac, ensuring that the latter dipeptide that has reduced binding affinity with vancomycin is used to synthesize peptidoglycan substrate. antibiotic_resistance ARO:3000011 vanX VanX is a D,D-dipeptidase that cleaves D-Ala-D-Ala but not D-Ala-D-Lac, ensuring that the latter dipeptide that has reduced binding affinity with vancomycin is used to synthesize peptidoglycan substrate. PMID:7854121 Proteins involved in restructuring of the cell wall, causing antibiotic resistance. antibiotic_resistance ARO:3000012 protein(s) conferring antibiotic resistance via molecular bypass VanB is a D-Ala-D-Ala ligase homolog similar to VanA, and can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It has been isolated from VREs. It is associated with vancomycin resistance, but not teicoplanin resistance. vanB antibiotic_resistance ARO:3000013 vanB VanB is a D-Ala-D-Ala ligase homolog similar to VanA, and can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It has been isolated from VREs. It is associated with vancomycin resistance, but not teicoplanin resistance. PMID:9177243 vanB TEM-1 is the most commonly-encountered beta-lactamase in gram-negative bacteria. Up to 90% of ampicillin resistance in E. coli is due to the production of TEM-1. Also responsible for the ampicillin and penicillin resistance that is seen in H. influenzae and N. gonorrhoeae in increasing numbers. Although TEM-type beta-lactamases are most often found in E. coli and K. pneumoniae, they are also found in other species of gram-negative bacteria with increasing frequency. The amino acid substitutions responsible for the ESBL phenotype cluster around the active site of the enzyme and change its configuration, allowing access to oxyimino-beta-lactam substrates. Opening the active site to beta-lactam substrates also typically enhances the susceptibility of the enzyme to b-lactamase inhibitors, such as clavulanic acid. Although the inhibitor-resistant beta-lactamases are not ESBLs, they are often discussed with ESBLs because they are also derivatives of the classical TEM- or SHV-type enzymes. These enzymes were at first given the designation IRT for inhibitor-resistant TEM beta-lactamase; however, all have subsequently been renamed with numerical TEM designations. There are at least 19 distinct inhibitor-resistant TEM beta-lactamases. Inhibitor-resistant TEM beta-lactamases have been found mainly in clinical isolates of E. coli, but also some strains of K. pneumoniae, Klebsiella oxytoca, P. mirabilis, and Citrobacter freundii. Although the inhibitor-resistant TEM variants are resistant to inhibition by clavulanic acid and sulbactam, thereby showing clinical resistance to the beta-lactam-lactamase inhibitor combinations of amoxicillin-clavulanate (Co-amoxiclav), ticarcillin-clavulanate, and ampicillin/sulbactam, they normally remain susceptible to inhibition by tazobactam and subsequently the combination of piperacillin/tazobactam, although resistance has been described. antibiotic_resistance ARO:3000014 TEM beta-lactamase TEM-1 is the most commonly-encountered beta-lactamase in gram-negative bacteria. Up to 90% of ampicillin resistance in E. coli is due to the production of TEM-1. Also responsible for the ampicillin and penicillin resistance that is seen in H. influenzae and N. gonorrhoeae in increasing numbers. Although TEM-type beta-lactamases are most often found in E. coli and K. pneumoniae, they are also found in other species of gram-negative bacteria with increasing frequency. The amino acid substitutions responsible for the ESBL phenotype cluster around the active site of the enzyme and change its configuration, allowing access to oxyimino-beta-lactam substrates. Opening the active site to beta-lactam substrates also typically enhances the susceptibility of the enzyme to b-lactamase inhibitors, such as clavulanic acid. Although the inhibitor-resistant beta-lactamases are not ESBLs, they are often discussed with ESBLs because they are also derivatives of the classical TEM- or SHV-type enzymes. These enzymes were at first given the designation IRT for inhibitor-resistant TEM beta-lactamase; however, all have subsequently been renamed with numerical TEM designations. There are at least 19 distinct inhibitor-resistant TEM beta-lactamases. Inhibitor-resistant TEM beta-lactamases have been found mainly in clinical isolates of E. coli, but also some strains of K. pneumoniae, Klebsiella oxytoca, P. mirabilis, and Citrobacter freundii. Although the inhibitor-resistant TEM variants are resistant to inhibition by clavulanic acid and sulbactam, thereby showing clinical resistance to the beta-lactam-lactamase inhibitor combinations of amoxicillin-clavulanate (Co-amoxiclav), ticarcillin-clavulanate, and ampicillin/sulbactam, they normally remain susceptible to inhibition by tazobactam and subsequently the combination of piperacillin/tazobactam, although resistance has been described. PMID:11585791 PMID:8432315 SHV-1 shares 68 percent of its amino acids with TEM-1 and has a similar overall structure. The SHV-1 beta-lactamase is most commonly found in K. pneumoniae and is responsible for up to 20% of the plasmid-mediated ampicillin resistance in this species. ESBLs in this family also have amino acid changes around the active site, most commonly at positions 238 or 238 and 240. More than 60 SHV varieties are known. antibiotic_resistance ARO:3000015 SHV beta-lactamase SHV-1 shares 68 percent of its amino acids with TEM-1 and has a similar overall structure. The SHV-1 beta-lactamase is most commonly found in K. pneumoniae and is responsible for up to 20% of the plasmid-mediated ampicillin resistance in this species. ESBLs in this family also have amino acid changes around the active site, most commonly at positions 238 or 238 and 240. More than 60 SHV varieties are known. PMID:11585791 These enzymes were named for their greater activity against cefotaxime than other oxyimino-beta-lactam substrates (eg, ceftazidime, ceftriaxone, or cefepime). Rather than arising by mutation, they represent examples of plasmid acquisition of beta-lactamase genes normally found on the chromosome of Kluyvera species, a group of rarely pathogenic commensal organisms. These enzymes are not very closely related to TEM or SHV beta-lactamases in that they show only approximately 40% identity with these two commonly isolated beta-lactamases. Despite their name, a few are more active on ceftazidime than cefotaxime. CTX-M-15 was recently found in bacterial strains expressing NDM-1 and were responsible for resistance to aztreonam. antibiotic_resistance ARO:3000016 CTX-M beta-lactamase These enzymes were named for their greater activity against cefotaxime than other oxyimino-beta-lactam substrates (eg, ceftazidime, ceftriaxone, or cefepime). Rather than arising by mutation, they represent examples of plasmid acquisition of beta-lactamase genes normally found on the chromosome of Kluyvera species, a group of rarely pathogenic commensal organisms. These enzymes are not very closely related to TEM or SHV beta-lactamases in that they show only approximately 40% identity with these two commonly isolated beta-lactamases. Despite their name, a few are more active on ceftazidime than cefotaxime. CTX-M-15 was recently found in bacterial strains expressing NDM-1 and were responsible for resistance to aztreonam. PMID:20705517 OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime. antibiotic_resistance ARO:3000017 OXA beta-lactamase OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime. PMID:16891520 PMID:24696435 IMI beta-lactamases are a group of TEM-1-like beta-lactamase that are known to hydrolyze imipenem. IMI beta-lactamases are inhibited by clavulanic acid and tazobactam. antibiotic_resistance ARO:3000018 IMI beta-lactamase IMI beta-lactamases are a group of TEM-1-like beta-lactamase that are known to hydrolyze imipenem. IMI beta-lactamases are inhibited by clavulanic acid and tazobactam. PMID:8878585 Plasmid mediated IMP-type carbapenemases, of which at least 26 varieties are currently known, became established in Japan in the 1990s in enteric gram-negative organisms, Pseudomonas and Acinetobacter species. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors. antibiotic_resistance ARO:3000020 IMP beta-lactamase Plasmid mediated IMP-type carbapenemases, of which at least 26 varieties are currently known, became established in Japan in the 1990s in enteric gram-negative organisms, Pseudomonas and Acinetobacter species. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors. PMID:20121112 PMID:8141584 The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants. VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors. There is a strong incidence of these in East Asia. antibiotic_resistance ARO:3000021 VIM beta-lactamase The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants. VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors. There is a strong incidence of these in East Asia. PMID:12562689 PMID:18061205 PMID:20121112 Ristocetin is a glycopeptide antibiotic similar to vancomycin but positively charged. It is not used clinically because it induces platelet agglutination. pubchem.compound:16204749 antibiotic_resistance ARO:3000022 ristocetin Ristocetin is a glycopeptide antibiotic similar to vancomycin but positively charged. It is not used clinically because it induces platelet agglutination. PMID:17620 PMID:2532132 Subunit of the topoisomerase IV sensitive to aminocoumarins. antibiotic_resistance ARO:3000023 aminocoumarin sensitive parE Subunit of the topoisomerase IV sensitive to aminocoumarins. PMID:12604514 PMID:16127057 PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance. patA antibiotic_resistance ARO:3000024 patA PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance. PMID:20709735 PMID:20937787 patA PatB is an ABC transporter of Streptococcus pneumoniae that interacts with PatA to confer fluoroquinolone resistance.. patB antibiotic_resistance ARO:3000025 patB PatB is an ABC transporter of Streptococcus pneumoniae that interacts with PatA to confer fluoroquinolone resistance.. PMID:20709735 PMID:20937787 patB MepA is an efflux protein regulated by MepR and part of the MepRAB cluster. Its presence in Staphylococcus aureus led to multidrug resistance, while it has also been shown to decrease tigecycline susceptibility. mepA antibiotic_resistance ARO:3000026 mepA MepA is an efflux protein regulated by MepR and part of the MepRAB cluster. Its presence in Staphylococcus aureus led to multidrug resistance, while it has also been shown to decrease tigecycline susceptibility. PMID:15855507 PMID:15855508 PMID:16569840 mepA EmrA is a membrane fusion protein, providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli, a Gram-negative bacterium. emrA antibiotic_resistance ARO:3000027 emrA EmrA is a membrane fusion protein, providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli, a Gram-negative bacterium. PMID:7730261 emrA Nucleoside antibiotics are made of modified nucleosides and nucleotides with wide-ranging activities and means of antibacterial effects. This drug class includes aminonucleoside antibiotics, which contain an amino group. antibiotic_resistance ARO:3000034 nucleoside antibiotic Nucleoside antibiotics are made of modified nucleosides and nucleotides with wide-ranging activities and means of antibacterial effects. This drug class includes aminonucleoside antibiotics, which contain an amino group. PMID:18679046 PMID:3061990 Lipopeptide antibiotics are aliphatic, with their hydrophobic components interacting with the bacterial cell membrane. antibiotic_resistance ARO:3000035 lipopeptide antibiotic Lipopeptide antibiotics are aliphatic, with their hydrophobic components interacting with the bacterial cell membrane. PMID:19156787 Enzymes or other gene products which hydroxylate tetracycline and other tetracycline derivatives. Hydroxylation inactivates tetracycline-like antibiotics, thus conferring resistance to these compounds. antibiotic_resistance ARO:3000036 tetracycline inactivation enzyme Enzymes or other gene products which hydroxylate tetracycline and other tetracycline derivatives. Hydroxylation inactivates tetracycline-like antibiotics, thus conferring resistance to these compounds. PMID:24497223 Hydrolysis of an antibiotic molecule to confer resistance. antibiotic_resistance ARO:3000040 hydrolysis of antibiotic conferring resistance Antibiotic adjuvants shown to inhibit the action of a beta-lactamase enzyme or enhance the ability of a beta-lactam antibiotic. These compounds are used along with antibiotics to treat beta-lactam-resistant infectious pathogens. antibiotic_resistance ARO:3000042 beta-lactamase inhibitor VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. antibiotic_resistance ARO:3000043 VEB beta-lactamase VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. PMID:10049269 A collection of curated phenotypic terms relating to antibiotic resistance and the Comprehensive Antibiotic Resistance Database. antibiotic_resistance ARO:3000045 component of AMR genotypic or phenotypic terminology These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes. antibiotic_resistance ARO:3000050 tetracycline antibiotic These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes. PMID:11381101 Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics. antibiotic_resistance ARO:3000053 peptide antibiotic Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics. PMID:10348745 PMID:18065456 SME beta-lactamases are chromosome-mediated class A beta-lactamases that hydrolyze carbapenems in Serratia marcescens. antibiotic_resistance ARO:3000055 SME beta-lactamase SME beta-lactamases are chromosome-mediated class A beta-lactamases that hydrolyze carbapenems in Serratia marcescens. PMID:8092824 PER beta-lactamases are plasmid-mediated extended spectrum beta-lactamases found in the Enterobacteriaceae family. antibiotic_resistance ARO:3000056 PER beta-lactamase NDM beta-lactamases or New Delhi metallo-beta-lactamases are class B beta-lactamases that confer resistance to a broad range of antibiotics including carbapenems, cephalosporins and penicillins. antibiotic_resistance ARO:3000057 NDM beta-lactamase NDM beta-lactamases or New Delhi metallo-beta-lactamases are class B beta-lactamases that confer resistance to a broad range of antibiotics including carbapenems, cephalosporins and penicillins. PMID:19770275 PMID:20705517 PMID:21393184 PMID:21507902 PMID:21624908 PMID:21930874 PMID:22078325 PMID:24165671 MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. antibiotic_resistance ARO:3000058 MIR beta-lactamase MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. PMID:1963529 Klebsiella pneumoniae carbapenem resistant (KPC) beta-lactamases are notorious for their ability to efficiently hydrolyze carbapenems, unlike other Ambler Class A beta-lactamases. There are currently 9 variants reported worldwide. These enzymes were first isolated from Klebsiella pneumoniae strains in 2001 in the United States. Hospital outbreaks have since been reported in Greece and Israel and KPC carrying strains are now endemic to New York facilities. KPC-1 and KPC-2 have been shown to be identical and are now referred to as KPC-2. antibiotic_resistance ARO:3000059 KPC beta-lactamase Klebsiella pneumoniae carbapenem resistant (KPC) beta-lactamases are notorious for their ability to efficiently hydrolyze carbapenems, unlike other Ambler Class A beta-lactamases. There are currently 9 variants reported worldwide. These enzymes were first isolated from Klebsiella pneumoniae strains in 2001 in the United States. Hospital outbreaks have since been reported in Greece and Israel and KPC carrying strains are now endemic to New York facilities. KPC-1 and KPC-2 have been shown to be identical and are now referred to as KPC-2. PMID:17441734 PMID:19493866 IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. antibiotic_resistance ARO:3000060 IND beta-lactamase IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. PMID:10077836 GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. antibiotic_resistance ARO:3000066 GES beta-lactamase FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. antibiotic_resistance ARO:3000067 FOX beta-lactamase FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. PMID:7811034 DHA beta-lactamases are plasmid-mediated AmpC β-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins. antibiotic_resistance ARO:3000068 DHA beta-lactamase DHA beta-lactamases are plasmid-mediated AmpC β-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins. PMID:9736562 CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins. antibiotic_resistance ARO:3000069 CMY beta-lactamase VanS is similar to histidine protein kinases like EnvZ and acts as a response regulator by activating VanR. VanS is required for high level transcription of other van glycopeptide resistance genes. antibiotic_resistance ARO:3000071 vanS VanS is similar to histidine protein kinases like EnvZ and acts as a response regulator by activating VanR. VanS is required for high level transcription of other van glycopeptide resistance genes. PMID:1556077 ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae. antibiotic_resistance ARO:3000072 ACT beta-lactamase ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae. PMID:9055993 ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins. antibiotic_resistance ARO:3000073 ACC beta-lactamase ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins. PMID:10428914 emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP), nalidixic acid, and thioloactomycin. emrB antibiotic_resistance ARO:3000074 emrB emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP), nalidixic acid, and thioloactomycin. PMID:1409590 emrB Class D beta-lactamases are one of the subgroups of beta-lactamases that are classified as serine enzymes. antibiotic_resistance ARO:3000075 class D beta-lactamase AmpC type beta-lactamases are commonly isolated from extended-spectrum cephalosporin-resistant Gram-negative bacteria. AmpC beta-lactamases (also termed class C or group 1) are typically encoded on the chromosome of many Gram-negative bacteria including Citrobacter, Serratia, Enterobacter species, and P. aeruginosa where its expression is usually inducible; it may also occur on Escherichia coli but is not usually inducible, although it can be hyperexpressed. AmpC type beta-lactamases may also be carried on plasmids. AmpC beta-lactamases, in contrast to ESBLs, hydrolyse broad and extended-spectrum cephalosporins (cephamycins as well as to oxyimino-beta-lactams) but are not inhibited by beta-lactamase inhibitors such as clavulanic acid. AmpC beta-lactamase antibiotic_resistance ARO:3000076 class C beta-lactamase AmpC type beta-lactamases are commonly isolated from extended-spectrum cephalosporin-resistant Gram-negative bacteria. AmpC beta-lactamases (also termed class C or group 1) are typically encoded on the chromosome of many Gram-negative bacteria including Citrobacter, Serratia, Enterobacter species, and P. aeruginosa where its expression is usually inducible; it may also occur on Escherichia coli but is not usually inducible, although it can be hyperexpressed. AmpC type beta-lactamases may also be carried on plasmids. AmpC beta-lactamases, in contrast to ESBLs, hydrolyse broad and extended-spectrum cephalosporins (cephamycins as well as to oxyimino-beta-lactams) but are not inhibited by beta-lactamase inhibitors such as clavulanic acid. PMID:19822890 VanY is a D,D-carboxypeptidase that cleaves removes the terminal D-Ala from peptidoglycan for the addition of D-Lactate. The D-Ala-D-Lac peptidoglycan subunits have reduced binding affinity with vancomycin compared to D-Ala-D-Ala. antibiotic_resistance ARO:3000077 vanY VanY is a D,D-carboxypeptidase that cleaves removes the terminal D-Ala from peptidoglycan for the addition of D-Lactate. The D-Ala-D-Lac peptidoglycan subunits have reduced binding affinity with vancomycin compared to D-Ala-D-Ala. PMID:16323116 PMID:24711382 The Class A beta-lactamases are one of the subgroups of beta-lactamases that are classified as serine enzymes. Class A beta-lactamases exhibit a large degree of variability and are known to hydrolyze penicillins. antibiotic_resistance ARO:3000078 class A beta-lactamase The Class A beta-lactamases are one of the subgroups of beta-lactamases that are classified as serine enzymes. Class A beta-lactamases exhibit a large degree of variability and are known to hydrolyze penicillins. PMID:17407578 Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use. antibiotic_resistance ARO:3000079 oxazolidinone antibiotic Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use. PMID:18757750 Aminonucleoside antibiotics are nucleoside antibiotics that contain an amino group. This amino group is often acylated, e.g. puromycin. antibiotic_resistance ARO:3000080 aminonucleoside antibiotic Aminonucleoside antibiotics are nucleoside antibiotics that contain an amino group. This amino group is often acylated, e.g. puromycin. PMID:8576156 Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria. This inhibits transglycosylation leading to cell death due to osmotic stress. antibiotic_resistance ARO:3000081 glycopeptide antibiotic Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria. This inhibits transglycosylation leading to cell death due to osmotic stress. PMID:10232990 PMID:16007453 PMID:3276316 PMID:4369274 The biological synthesis of antibiotics. antibiotic_resistance ARO:3000082 antibiotic biosynthesis MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases. antibiotic_resistance ARO:3000083 MOX beta-lactamase A grouping of the related CMY, LAT, and MOX beta-lactamases. antibiotic_resistance ARO:3000085 CMY-LAT-MOX beta-lactamase A grouping of the related CMY and LAT beta-lactamases. antibiotic_resistance ARO:3000086 CMY-LAT beta-lactamase A grouping of the related CMY and MOX beta-lactamases. antibiotic_resistance ARO:3000087 CMY-MOX beta-lactamase AER beta-lactamases are capable of hydrolyzing arbenicillin. AsbB1 antibiotic_resistance ARO:3000089 AER beta-lactamase AER beta-lactamases are capable of hydrolyzing arbenicillin. PMID:9687391 Bla1 is a chromosomal-encoded beta-lactamase, found in Bacillus anthracis, which hydrolyzes penicillins. Bla1 antibiotic_resistance ARO:3000090 Bla1 Bla1 is a chromosomal-encoded beta-lactamase, found in Bacillus anthracis, which hydrolyzes penicillins. PMID:12760895 PMID:27557855 Bla1 CARB beta-lactamases are class A lactamases that can hydrolyze carbenicillin. Many of the PSE beta-lactamases have been renamed as CARB-lactamases with the notable exception of PSE-2 which is now OXA-10. antibiotic_resistance ARO:3000091 CARB beta-lactamase CARB beta-lactamases are class A lactamases that can hydrolyze carbenicillin. Many of the PSE beta-lactamases have been renamed as CARB-lactamases with the notable exception of PSE-2 which is now OXA-10. PMID:6782068 PMID:9687391 OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. antibiotic_resistance ARO:3000094 OCH beta-lactamase OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 SRT beta-lactamases. antibiotic_resistance ARO:3000095 SRT beta-lactamase A grouping of the related SHV and LEN beta-lactamases. antibiotic_resistance ARO:3000096 SHV-LEN beta-lactamase LEN beta-lactamases are chromosomal class A beta-lactamases that confer resistance to ampicillin, amoxicillin, carbenicillin, and ticarcillin but not to extended-spectrum beta-lactams. antibiotic_resistance ARO:3000097 LEN beta-lactamase LEN beta-lactamases are chromosomal class A beta-lactamases that confer resistance to ampicillin, amoxicillin, carbenicillin, and ticarcillin but not to extended-spectrum beta-lactams. PMID:15215087 PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa. antibiotic_resistance ARO:3000098 PDC beta-lactamase PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa. PMID:19258272 Genes that directly or indirectly modulate beta-lactam resistance. antibiotic_resistance ARO:3000100 gene modulating beta-lactam resistance Genes that directly or indirectly modulate beta-lactam resistance. PMID:16143832 Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. antibiotic_resistance ARO:3000103 aminocoumarin antibiotic Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. PMID:8231802 Phosphorylation of antibiotic usually by ATP, sometimes GTP. antibiotic_resistance ARO:3000105 phosphorylation of antibiotic conferring resistance Addition of an acyl group to an antibiotic, often via acetylation by acetylCoA. antibiotic_resistance ARO:3000106 acylation of antibiotic conferring resistance Modification by NMP, usually AMP. antibiotic_resistance ARO:3000107 nucleotidylation of antibiotic conferring resistance Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling. pubchem.compound:54675769 cathomycin streptonivicin antibiotic_resistance ARO:3000111 novobiocin Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling. PMID:10770754 PMID:4680802 PMID:8231802 Directed pumping of antibiotic out of a cell to confer resistance. Multidrug and toxic compound extrusion (MATE) transporters utilize the cationic gradient across the membrane as an energy source. Although there is a diverse substrate specificity, almost all MATE transporters recognize fluoroquinolones. Arciflavine, ethidium and aminoglycosides are also good substrates. antibiotic_resistance ARO:3000112 multidrug and toxic compound extrusion (MATE) transporter Directed pumping of antibiotic out of a cell to confer resistance. Multidrug and toxic compound extrusion (MATE) transporters utilize the cationic gradient across the membrane as an energy source. Although there is a diverse substrate specificity, almost all MATE transporters recognize fluoroquinolones. Arciflavine, ethidium and aminoglycosides are also good substrates. PMID:16330770 PMID:19100867 Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection. antibiotic_resistance ARO:3000113 vga-type ABC-F protein Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection. PMID:15728891 PMID:20876620 PMID:21768510 Kinases that modify aminoglycoside antibiotics by phosphorylation using NTPs as cofactor. aminoglycoside kinase antibiotic_resistance ARO:3000114 aminoglycoside phosphotransferase (APH) Kinases that modify aminoglycoside antibiotics by phosphorylation using NTPs as cofactor. PMID:20833577 PMID:9872733 ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Mutations in ParE prevents antibiotics from inhibiting DNA synthesis, thus conferring resistance. antibiotic_resistance ARO:3000115 antibiotic resistant DNA topoisomerase subunit parE VanZ is a teicoplanin resistance gene that is an accessory protein. VanZ prevents the incorporation of the terminal D-Ala into peptidoglycan subunits. antibiotic_resistance ARO:3000116 vanZ VanZ is a teicoplanin resistance gene that is an accessory protein. VanZ prevents the incorporation of the terminal D-Ala into peptidoglycan subunits. PMID:16323116 A47934 is an 'aglycone' glycopeptide antibiotic produced by Streptomyces toyocaensis. It is a teicoplanin-like glycopeptide. pubchem.compound:16131155 antibiotic_resistance ARO:3000117 antibiotic A47934 A47934 is an 'aglycone' glycopeptide antibiotic produced by Streptomyces toyocaensis. It is a teicoplanin-like glycopeptide. PMID:12060705 PMID:16492565 PMID:17884639 PMID:9435111 Vga(B) is an ABC-F protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. vgaB antibiotic_resistance ARO:3000118 vgaB Vga(B) is an ABC-F protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. PMID:15728891 PMID:9427556 vgaB Edeines are basic linear peptides produced by Bacillus brevis Vm4. They have antibacterial as well as antifungal, antiviral, and anticancer properties. Edeines are bacteriostatic and bacteriocidal at low and high concentrations, respectively. They are able to inhibit DNA synthesis and protein translation. These compounds are synthesized by nonribosomal peptide synthetases and contain numerous unusual amino acids. antibiotic_resistance ARO:3000119 edeine Edeines are basic linear peptides produced by Bacillus brevis Vm4. They have antibacterial as well as antifungal, antiviral, and anticancer properties. Edeines are bacteriostatic and bacteriocidal at low and high concentrations, respectively. They are able to inhibit DNA synthesis and protein translation. These compounds are synthesized by nonribosomal peptide synthetases and contain numerous unusual amino acids. PMID:70202 Balhimycin is a vancomycin-like glycopeptide antibiotic produced by Amycolatopsis balhimycina. It binds to the terminal Lys-D-Ala-D-Ala of peptidoglycan precursors. pubchem.compound:16134543 antibiotic_resistance ARO:3000120 balhimycin Balhimycin is a vancomycin-like glycopeptide antibiotic produced by Amycolatopsis balhimycina. It binds to the terminal Lys-D-Ala-D-Ala of peptidoglycan precursors. PMID:10390204 PMID:11495926 PMID:11932455 PMID:16730832 PMID:9761883 Aminoglycoside acetyltransferase enzymes modify aminoglycoside antibiotics by catalyzing the transfer of an acetyl group to one of the amino groups present in aminoglycosides, using acetyl coenzyme A as a donor substrate. aminoglycoside N-acetyltransferase antibiotic_resistance ARO:3000121 aminoglycoside acetyltransferase (AAC) Aminoglycoside acetyltransferase enzymes modify aminoglycoside antibiotics by catalyzing the transfer of an acetyl group to one of the amino groups present in aminoglycosides, using acetyl coenzyme A as a donor substrate. PMID:20833577 Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. antibiotic_resistance ARO:3000122 chloramphenicol acetyltransferase (CAT) Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. PMID:11553538 PMID:11677608 PMID:11735367 PMID:11743194 PMID:12603745 PMID:12650243 PMID:12726767 PMID:12732947 PMID:1406372 PMID:1461942 PMID:1517170 PMID:15539072 PMID:1650008 PMID:1713259 PMID:1929282 PMID:1929326 PMID:19459958 PMID:2013403 PMID:2227449 PMID:2697637 PMID:2993795 PMID:3110008 PMID:3860383 PMID:3865770 PMID:3900035 PMID:6950931 PMID:9349809 Gramicidins are a family of antibiotics synthesized by Bacillus brevis. It includes the linear pentadecapeptides gramicidin A, B and C that make up the mixture gramicidin D. Gramicidin S is a cyclic peptide chain. Gramicidins are also components of tyrothricins, another mixture of antibiotics produced by Bacillus brevis. pubchem.compound:16130140 antibiotic_resistance ARO:3000123 gramicidin mecI acts as a repressor of transcription of the mecA/mecR1/mecI operon. mecI antibiotic_resistance ARO:3000124 mecI mecI acts as a repressor of transcription of the mecA/mecR1/mecI operon. PMID:24564530 mecI The use of different nucleophilic molecules by enzymes can break up the epoxide ring of fosfomycin and render the molecule ineffective. antibiotic_resistance ARO:3000125 hydrolysis of fosfomycin epoxide ring A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. antibiotic_resistance ARO:3000126 APH(3') A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. PMID:8385262 PMID:9200607 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of streptomycin, by the ATP-dependent phosphorylation of the 3''-hydroxyl group of the compound. antibiotic_resistance ARO:3000127 APH(3'') A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin, tobramycin and amikacin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. antibiotic_resistance ARO:3000128 APH(2'') Edeine A is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and spermidine. Edeine A is a mixture of edeine A1 and its inactive isomer, edeine A2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. pubchem.compound:379085 antibiotic_resistance ARO:3000130 edeine A Edeine A is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and spermidine. Edeine A is a mixture of edeine A1 and its inactive isomer, edeine A2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. PMID:14731399 PMID:4984939 PMID:70202 Clorobiocin is an aminocoumarin antibiotic produced by Streptomyces roseochromogenes, and binds DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. pubchem.compound:54706138 antibiotic_resistance ARO:3000132 clorobiocin Clorobiocin is an aminocoumarin antibiotic produced by Streptomyces roseochromogenes, and binds DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. PMID:12044152 PMID:6154685 PMID:8231802 Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin. antibiotic_resistance ARO:3000133 fosfomycin thiol transferase Edeine B is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and guanylspermidine. Edeine B is a mixture of edeine B1 and its inactive isomer, edeine B2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. Edeine B has also been shown to inhibit septation and cause filamentous morphology, also leading to cell death. pubchem.compound:446232 antibiotic_resistance ARO:3000134 edeine B Edeine B is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and guanylspermidine. Edeine B is a mixture of edeine B1 and its inactive isomer, edeine B2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. Edeine B has also been shown to inhibit septation and cause filamentous morphology, also leading to cell death. PMID:20410587 PMID:4984939 PMID:70202 Edeine D is a subtype of edeine similar to edeine A with the beta-tyr replaced by beta-phe-beta-ala. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. pubchem.compound:170400 antibiotic_resistance ARO:3000135 edeine D Edeine D is a subtype of edeine similar to edeine A with the beta-tyr replaced by beta-phe-beta-ala. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. PMID:70202 Edeine F is a subtype of edeine similar to edeine B with beta-tyr replaced by beta-phe-beta-ala. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. pubchem.compound:194407 antibiotic_resistance ARO:3000136 edeine F Edeine F is a subtype of edeine similar to edeine B with beta-tyr replaced by beta-phe-beta-ala. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. PMID:6615592 Tylosin is a 16-membered macrolide, naturally produced by Streptomyces fradiae. It interacts with the bacterial ribosome 50S subunit to inhibit protein synthesis. pubchem.compound:5280440 antibiotic_resistance ARO:3000145 tylosin Tylosin is a 16-membered macrolide, naturally produced by Streptomyces fradiae. It interacts with the bacterial ribosome 50S subunit to inhibit protein synthesis. PMID:19793461 An enzyme that confers resistance to fosfomycin in Serratia marcescens by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. In Pseudomonas aeruginosa, FosA catalyzes the conjugation of glutathione to carbon-1 of fosfomycin, rendering it ineffective as an antibacterial drug. PDB:1NPB FosA antibiotic_resistance ARO:3000149 FosA An enzyme that confers resistance to fosfomycin in Serratia marcescens by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. In Pseudomonas aeruginosa, FosA catalyzes the conjugation of glutathione to carbon-1 of fosfomycin, rendering it ineffective as an antibacterial drug. PMID:15075406 PMID:15741169 FosA Coumermycin A1 is an antibiotic produced by Streptomyces rishiriensis, and binds DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. pubchem.compound:54675768 Notomycin A1 antibiotic_resistance ARO:3000150 coumermycin A1 Coumermycin A1 is an antibiotic produced by Streptomyces rishiriensis, and binds DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. PMID:11036020 PMID:14285468 PMID:14285469 PMID:8231802 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 6-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of streptomycin, by the ATP-dependent phosphorylation of the 6-hydroxyl group of the compound. antibiotic_resistance ARO:3000151 APH(6) Minocycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome. pubchem.compound:54675783 antibiotic_resistance ARO:3000152 minocycline Minocycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome. PMID:11381101 PMID:19862477 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 9-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of spectinomycin, by the ATP-dependent phosphorylation of the 9-hydroxyl group of the compound. antibiotic_resistance ARO:3000153 APH(9) A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 9-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of spectinomycin, by the ATP-dependent phosphorylation of the 9-hydroxyl group of the compound. PMID:20089863 PMID:9614079 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 7''-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of hygromycin, by the ATP-dependent phosphorylation of the 7''-hydroxyl group of the compound. antibiotic_resistance ARO:3000154 APH(7'') A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 4-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of hygromycin, by the ATP-dependent phosphorylation of the 4-hydroxyl group of the compound. antibiotic_resistance ARO:3000155 APH(4) A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 4-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of hygromycin, by the ATP-dependent phosphorylation of the 4-hydroxyl group of the compound. PMID:21084294 Spiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis. pubchem.compound:6419898 rovamycin antibiotic_resistance ARO:3000156 spiramycin Spiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis. PMID:7683018 Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs. antibiotic_resistance ARO:3000157 rifamycin antibiotic Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs. PMID:15700959 Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation. pubchem.compound:447043 AZM antibiotic_resistance ARO:3000158 azithromycin Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation. PMID:1662624 Efflux proteins that pump antibiotic out of a cell to confer resistance. antibiotic_resistance ARO:3000159 efflux pump complex or subunit conferring antibiotic resistance blaI acts as a repressor of transcription of the blaZ/blaR1/blaI operon. blaI antibiotic_resistance ARO:3000160 blaI blaI acts as a repressor of transcription of the blaZ/blaR1/blaI operon. PMID:12654668 blaI Catalyzes methylation of rRNA. antibiotic_resistance ARO:3000164 rRNA methyltransferase conferring antibiotic resistance Catalyzes methylation of rRNA. PMID:1929280 TetA is a tetracycline efflux pump found in many species of Gram-negative bacteria. tet(A) tetA antibiotic_resistance ARO:3000165 tet(A) TetA is a tetracycline efflux pump found in many species of Gram-negative bacteria. PMID:15837373 PMID:8821947 tet(A) Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline, doxycycline, and minocycline, but not tigecycline. tet(B) tetB antibiotic_resistance ARO:3000166 tet(B) Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline, doxycycline, and minocycline, but not tigecycline. PMID:15837373 tet(B) Tet(C) is a tetracycline efflux pump found in many species of Gram-negative bacteria. It is typically found in plasmid DNA. tet(C) tetC antibiotic_resistance ARO:3000167 tet(C) Tet(C) is a tetracycline efflux pump found in many species of Gram-negative bacteria. It is typically found in plasmid DNA. PMID:6307828 tet(C) TetD is a tetracycline efflux pump found exclusively in Gram-negative bacteria. tet(D) tetD antibiotic_resistance ARO:3000168 tet(D) TetD is a tetracycline efflux pump found exclusively in Gram-negative bacteria. PMID:15837373 tet(D) Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections. pubchem.compound:135398735 rifampicin antibiotic_resistance ARO:3000169 rifampin Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections. PMID:15667909 PMID:6356275 Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes. pubchem.compound:104838 antibiotic_resistance ARO:3000170 imipenem Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes. PMID:10629005 PMID:12084099 Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups. They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis. diaminopyrimidine antibiotic_resistance ARO:3000171 diaminopyrimidine antibiotic Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups. They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis. PMID:8195830 A thiol transferase that leads to the resistance of fosfomycin. Contrasting FosA, FosB is dependent on the cofactor Magnesium (II) and uses either bacillithiol or L-cysteine to open up the epoxide ring of fosfomycin. PDB:4JH1 FosB antibiotic_resistance ARO:3000172 FosB A thiol transferase that leads to the resistance of fosfomycin. Contrasting FosA, FosB is dependent on the cofactor Magnesium (II) and uses either bacillithiol or L-cysteine to open up the epoxide ring of fosfomycin. PMID:24004181 PMID:24447055 FosB TetE is a tetracycline efflux pump found in many Gram-negative bacteria, especially those in water environments. The gene is found on large plasmids. tet(E) tetE antibiotic_resistance ARO:3000173 tet(E) TetE is a tetracycline efflux pump found in many Gram-negative bacteria, especially those in water environments. The gene is found on large plasmids. PMID:15837373 tet(E) TetG is a tetracycline efflux protein found in Gram-negative bacteria. The encoding gene is found in both chromosomal and plasmid DNA where it is frequently linked to the floR, sul1, and cmlA9 genes which encode proteins that can confer florfenicol/chloramphenicol, sulfamethoxazole, and chloramphenicol resistance, respectively. tet(G) tetG antibiotic_resistance ARO:3000174 tet(G) TetG is a tetracycline efflux protein found in Gram-negative bacteria. The encoding gene is found in both chromosomal and plasmid DNA where it is frequently linked to the floR, sul1, and cmlA9 genes which encode proteins that can confer florfenicol/chloramphenicol, sulfamethoxazole, and chloramphenicol resistance, respectively. PMID:15837373 tet(G) TetH is a tetracycline efflux protein expressed in Gram-negative bacteria (Actinobacillus, Acinetobacter, Gallibacterium, Histophilus, Mannheimia, Moraxella, Pasteurella, and Psychrobacter). Its gene is linked to the resistance genes sul2, and strAB, which confer resistance to sulfamethoxazole and streptomycin, respectively. tet(H) tetH antibiotic_resistance ARO:3000175 tet(H) TetH is a tetracycline efflux protein expressed in Gram-negative bacteria (Actinobacillus, Acinetobacter, Gallibacterium, Histophilus, Mannheimia, Moraxella, Pasteurella, and Psychrobacter). Its gene is linked to the resistance genes sul2, and strAB, which confer resistance to sulfamethoxazole and streptomycin, respectively. PMID:15837373 tet(H) Dirithromycin is an oxazine derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome to inhibit bacterial protein synthesis. pubchem.compound:6473883 antibiotic_resistance ARO:3000176 dirithromycin Dirithromycin is an oxazine derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome to inhibit bacterial protein synthesis. PMID:7683018 TetJ is a tetracycline efflux protein expressed in Gram-negative bacteria (Escherichia, Morganella, and Proteus). tet(J) tetJ antibiotic_resistance ARO:3000177 tet(J) TetJ is a tetracycline efflux protein expressed in Gram-negative bacteria (Escherichia, Morganella, and Proteus). PMID:15837373 tet(J) TetK is a tetracycline efflux protein found in both Gram-negative (Haemophilus and Gallibacterium) and Gram-positive (many species, including mycobacteria) bacteria. tet(K) tetK antibiotic_resistance ARO:3000178 tet(K) TetK is a tetracycline efflux protein found in both Gram-negative (Haemophilus and Gallibacterium) and Gram-positive (many species, including mycobacteria) bacteria. PMID:15837373 PMID:7781778 PMID:8234490 tet(K) TetL is a tetracycline efflux protein found in many species of Gram-negative and Gram-positive bacteria. tet(L) tetL antibiotic_resistance ARO:3000179 tet(L) TetL is a tetracycline efflux protein found in many species of Gram-negative and Gram-positive bacteria. PMID:15837373 PMID:3324958 tet(L) TetA(P) is a inner membrane tetracycline efflux protein found on the same operon as the ribosomal protection protein TetB(P). It is found in Clostridium, a Gram-positive bacterium. tetA(P) tetP antibiotic_resistance ARO:3000180 tetA(P) TetA(P) is a inner membrane tetracycline efflux protein found on the same operon as the ribosomal protection protein TetB(P). It is found in Clostridium, a Gram-positive bacterium. PMID:14702405 PMID:15837373 tetA(P) TetV is a tetracycline efflux protein that has been found in Mycolicibacterium smegmatis and Mycolicibacterium fortuitum. tet(V) tetV antibiotic_resistance ARO:3000181 tet(V) TetV is a tetracycline efflux protein that has been found in Mycolicibacterium smegmatis and Mycolicibacterium fortuitum. PMID:15837373 PMID:22673307 PMID:9687386 tet(V) TetY is a tetracycline efflux pump found in Gram-negative bacteria (Aeromonas and Escherichia). It is associated with plasmid DNA. tet(Y) tetY antibiotic_resistance ARO:3000182 tet(Y) TetY is a tetracycline efflux pump found in Gram-negative bacteria (Aeromonas and Escherichia). It is associated with plasmid DNA. PMID:15837373 tet(Y) TetZ is a tetracycline efflux protein found in Gram-positive bacteria (Corynebacterium and Lactobacillus). It is associated with plasmid DNA. tet(Z) tetZ antibiotic_resistance ARO:3000183 tet(Z) TetZ is a tetracycline efflux protein found in Gram-positive bacteria (Corynebacterium and Lactobacillus). It is associated with plasmid DNA. PMID:15837373 tet(Z) Chloroeremomycin is a vancomycin-like glycopeptide, with three sugars instead of two in vancomycin and balhimycin. Chloroeremomycin dimerizes and binds to the terminus of peptidoglycan precursors. pubchem.compound:445806 antibiotic_resistance ARO:3000184 chloroeremomycin Chloroeremomycin is a vancomycin-like glycopeptide, with three sugars instead of two in vancomycin and balhimycin. Chloroeremomycin dimerizes and binds to the terminus of peptidoglycan precursors. PMID:11035791 PMID:11942828 PMID:9545426 These proteins confer antibiotic resistance by bind the antibiotic target to prevent antibiotic binding. antibiotic_resistance ARO:3000185 antibiotic target protection protein Tet(M) is a ribosomal protection protein that confers tetracycline resistance. It is found on transposable DNA elements and its horizontal transfer between bacterial species has been documented. tet(M) tetM antibiotic_resistance ARO:3000186 tet(M) Tet(M) is a ribosomal protection protein that confers tetracycline resistance. It is found on transposable DNA elements and its horizontal transfer between bacterial species has been documented. PMID:19475445 tet(M) Mechanism of enzymatic degradation common to Ambler Class A, C and D beta-lactamases. A serine residue located in the active site is used to form an acyl-enzyme intermediate and subsequent hydrolysis renders the beta-lactam inactive. antibiotic_resistance ARO:3000187 hydrolysis of beta-lactam antibiotic by serine beta-lactamase Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic. pubchem.compound:5578 antibiotic_resistance ARO:3000188 trimethoprim Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic. PMID:11432417 PMID:18024520 Oritavancin is a semi-synthetic derivative of chloroeremomycin, a vancomycin-like glycopeptide. Oritavancin inhibits both transglycosylation and transpeptidation, by binding both the D-Ala-D-Ala and pentaglycine bridge segments of peptidoglycan to inhibit cell wall formation. pubchem.compound:16136912 antibiotic_resistance ARO:3000189 oritavancin Oritavancin is a semi-synthetic derivative of chloroeremomycin, a vancomycin-like glycopeptide. Oritavancin inhibits both transglycosylation and transpeptidation, by binding both the D-Ala-D-Ala and pentaglycine bridge segments of peptidoglycan to inhibit cell wall formation. PMID:15954849 PMID:18258256 PMID:27904526 Tet(O) is a ribosomal protection protein. It is associated with conjugative plasmids. tet(O) tetO antibiotic_resistance ARO:3000190 tet(O) Tet(O) is a ribosomal protection protein. It is associated with conjugative plasmids. PMID:2841293 PMID:9848445 tet(O) Tet(Q) is a ribosomal protection protein. Its gene is associated with a conjugative transposon and has been found in both Gram-positive and Gram-negative bacteria. tet(Q) tetA(Q) tetQ antibiotic_resistance ARO:3000191 tet(Q) Tet(Q) is a ribosomal protection protein. Its gene is associated with a conjugative transposon and has been found in both Gram-positive and Gram-negative bacteria. PMID:20826220 PMID:9372425 tet(Q) Tet(S) is a ribosomal protection protein found in Gram-positive and Gram-negative strains. It is similar to tet(M) and tet(O). tet(S) tetS antibiotic_resistance ARO:3000192 tet(S) Tet(S) is a ribosomal protection protein found in Gram-positive and Gram-negative strains. It is similar to tet(M) and tet(O). PMID:7840565 PMID:8370538 tet(S) Tet(T) is a ribosomal protection protein of streptococci. It is similar to Tet(Q). tet(T) tetT antibiotic_resistance ARO:3000193 tet(T) Tet(T) is a ribosomal protection protein of streptococci. It is similar to Tet(Q). PMID:8980765 tet(T) Tet(W) is a ribosomal protection protein. It is associated with both conjugative and non conjugative DNA and has been found strains of Clostridioides difficile. tet(W) tetW antibiotic_resistance ARO:3000194 tet(W) Tet(W) is a ribosomal protection protein. It is associated with both conjugative and non conjugative DNA and has been found strains of Clostridioides difficile. PMID:10681357 tet(W) TetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P), a tetracycline efflux protein. tetB(P) tetP antibiotic_resistance ARO:3000195 tetB(P) TetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P), a tetracycline efflux protein. PMID:15837373 tetB(P) Tet(32) is a tetracycline resistance gene similar to Tet(O), and binds to the ribosome to confer tetracycline resistance as a ribosomal protection protein. tet(32) tet32 antibiotic_resistance ARO:3000196 tet(32) Tet(32) is a tetracycline resistance gene similar to Tet(O), and binds to the ribosome to confer tetracycline resistance as a ribosomal protection protein. PMID:11600392 PMID:18955517 tet(32) Tet(36) is a tetracycline resistance gene found in Bacteroides similar to Tet(Q), and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein. tet(36) tet36 antibiotic_resistance ARO:3000197 tet(36) Tet(36) is a tetracycline resistance gene found in Bacteroides similar to Tet(Q), and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein. PMID:12839793 tet(36) FosX is an enzyme used to confer resistance to fosfomycin. It's dependent on the cofactor, manganese (II), and uses water to generate a vicinal diol. PDB:2P7K FosX antibiotic_resistance ARO:3000198 FosX FosX is an enzyme used to confer resistance to fosfomycin. It's dependent on the cofactor, manganese (II), and uses water to generate a vicinal diol. PMID:17567049 FosX Gramicidin D is a mixture of the linear peptides gramicidin A, B, and C, each with 15 alternating L- and D-amino acids. They are active against most gram-positive bacteria and select gram-negative bacteria. These compounds create channels in the bacterial membrane and increase the permeability to cations. pubchem.compound:45267103 antibiotic_resistance ARO:3000199 gramicidin D Gramicidin D is a mixture of the linear peptides gramicidin A, B, and C, each with 15 alternating L- and D-amino acids. They are active against most gram-positive bacteria and select gram-negative bacteria. These compounds create channels in the bacterial membrane and increase the permeability to cations. PMID:17572379 PMID:9672588 Gramicidin S is a cyclical decapeptide with two pentapeptides (Val-Orn-Leu-D-Phe-Pro) joined head to tail. Like other gramicidins, Gramicidin S disrupts membrane permeability of cations while also destabilizing the membrane at higher concentrations. pubchem.compound:73357 antibiotic_resistance ARO:3000200 gramicidin S Gramicidin S is a cyclical decapeptide with two pentapeptides (Val-Orn-Leu-D-Phe-Pro) joined head to tail. Like other gramicidins, Gramicidin S disrupts membrane permeability of cations while also destabilizing the membrane at higher concentrations. PMID:10590309 PMID:8836773 Enzymes shown to inactivate macrolide antibiotics by chemical modification, thereby conferring resistance to macrolides. antibiotic_resistance ARO:3000201 macrolide inactivation enzyme Cfr genes produce enzymes which catalyze the methylation of the 23S rRNA subunit at position 8 of adenine-2503. Methylation of 23S rRNA at this site confers resistance to some classes of antibiotics, including streptogramins, chloramphenicols, florfenicols, linezolids and clindamycin. antibiotic_resistance ARO:3000202 Cfr 23S ribosomal RNA methyltransferase Cfr genes produce enzymes which catalyze the methylation of the 23S rRNA subunit at position 8 of adenine-2503. Methylation of 23S rRNA at this site confers resistance to some classes of antibiotics, including streptogramins, chloramphenicols, florfenicols, linezolids and clindamycin. PMID:11476839 PMID:17555436 PMID:20144045 PMID:20598637 PMID:22547628 PMID:23752511 PMID:28663118 Mechanism of enzymatic degradation common to Ambler Class B beta-lactamases. One or two zinc atoms are used to orient a hydroxide nucleophile for attack of the beta-lactam ring. In contrast to serine beta-lactamases, no acyl-enzyme intermediate is formed. antibiotic_resistance ARO:3000203 hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase Mechanism of enzymatic degradation common to Ambler Class B beta-lactamases. One or two zinc atoms are used to orient a hydroxide nucleophile for attack of the beta-lactam ring. In contrast to serine beta-lactamases, no acyl-enzyme intermediate is formed. PMID:20564281 Tet(X) is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics. Tet(X) hydroxylates position 11a of the tetraketide group thus inactivating the antibiotic. PDB:2XYO tet(X) tetX antibiotic_resistance ARO:3000205 tet(X) Tet(X) is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics. Tet(X) hydroxylates position 11a of the tetraketide group thus inactivating the antibiotic. PMID:15452119 PMID:16128584 PMID:1846135 PMID:21402075 tet(X) emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC, it mediates multidrug efflux. emrK antibiotic_resistance ARO:3000206 emrK emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC, it mediates multidrug efflux. PMID:12501312 emrK Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrA represents the periplasmic portion of the transport protein. antibiotic_resistance ARO:3000207 acrA Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrA represents the periplasmic portion of the transport protein. PMID:10931319 PMID:14706082 PMID:15226509 PMID:16531241 Addition of glycosyl moiety to antibiotics thereby inactivating them. antibiotic_resistance ARO:3000208 glycosylation of antibiotic conferring resistance ParY is part of a topoisomerase IV that is resistant to antibiotics that affect other topoisomerases. antibiotic_resistance ARO:3000209 antibiotic resistant DNA topoisomerase subunit parY Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin. antibiotic_resistance ARO:3000210 rifamycin-resistant beta-subunit of RNA polymerase (rpoB) Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin. PMID:10543773 PMID:11136757 PMID:12821473 PMID:15047531 PMID:21300839 PMID:22361457 PMID:3050121 Chemical alteration of the ribosome results in modification of an antibiotic's target leading to resistance. antibiotic_resistance ARO:3000211 ribosomal alteration conferring antibiotic resistance Point mutations in the DNA may lead to an altered gene product that may result in antibiotic resistance. Examples included modified antibiotic targets with lower binding affinities and the deactivation of repressors that result in increased expression of genes that inactivate or pump out antibiotics. antibiotic_resistance ARO:3000212 mutation conferring antibiotic resistance Peptidoglycan precursors ending in D-Ala-D-Lac or D-Ala-D-Ser instead of D-Ala-D-Ala conferring high level glycopeptide resistance. molecular bypass conferring antibiotic resistance antibiotic_resistance ARO:3000213 restructuring of bacterial cell wall conferring antibiotic resistance Peptidoglycan precursors ending in D-Ala-D-Lac or D-Ala-D-Ser instead of D-Ala-D-Ala conferring high level glycopeptide resistance. PMID:1931965 PMID:9177243 Hygromycin B is an aminoglycoside antibiotic used to treat different types of bacterial infections. Hygromycin B works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Hygromycin B has also been shown to interact with eukaryotic cells. pubchem.compound:35766 antibiotic_resistance ARO:3000214 hygromycin B Hygromycin B is an aminoglycoside antibiotic used to treat different types of bacterial infections. Hygromycin B works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Hygromycin B has also been shown to interact with eukaryotic cells. PMID:10103173 PMID:11163189 mecR1 is a transmembrane spanning and signal transducing protein which in response to interaction with beta-lactam antibiotics results in upregulation of the mecA/mecR1/mecI operon. mecR1 antibiotic_resistance ARO:3000215 mecR1 mecR1 is a transmembrane spanning and signal transducing protein which in response to interaction with beta-lactam antibiotics results in upregulation of the mecA/mecR1/mecI operon. PMID:1544435 mecR1 Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. PDB:1IWG ECK0456 JW0451 acrB antibiotic_resistance ARO:3000216 acrB Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. PMID:12374972 PMID:17275331 PMID:18073115 PMID:19166984 PMID:19453279 acrB blaR1 is a transmembrane spanning and signal transducing protein which in response to interaction with beta-lactam antibiotics results in upregulation of the blaZ/blaR1/blaI operon. blaR1 antibiotic_resistance ARO:3000217 blaR1 blaR1 Covalent modification of aminoglycoside antibiotic hydroxyl group by ATP-dependent transfer of AMP. aminoglycoside adenyltransferase antibiotic_resistance ARO:3000218 aminoglycoside nucleotidyltransferase (ANT) Covalent modification of aminoglycoside antibiotic hydroxyl group by ATP-dependent transfer of AMP. PMID:20833577 Efflux regulatory proteins with mutations that result in increased expression of efflux proteins. antibiotic_resistance ARO:3000219 mutant efflux regulatory protein conferring antibiotic resistance Point mutations in gyrB confer antibiotic resistance by preventing drugs from binding the beta-subunit of gyrase, essential for DNA supercoiling. antibiotic_resistance ARO:3000220 antibiotic resistant DNA topoisomerase subunit gyrB Resistance to the lincosamide antibiotic by ATP-dependent modification of the 3' and/or 4'-hydroxyl groups of the methylthiolincosamide sugar. antibiotic_resistance ARO:3000221 lincosamide nucleotidyltransferase (LNU) Resistance to the lincosamide antibiotic by ATP-dependent modification of the 3' and/or 4'-hydroxyl groups of the methylthiolincosamide sugar. PMID:11797175 Gramicidin A is the most abundant (more than 80%) of the three gramicidins in gramicidin D, with a tryptophan in position 11. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations. pubchem.compound:16132269 antibiotic_resistance ARO:3000222 gramicidin A Gramicidin A is the most abundant (more than 80%) of the three gramicidins in gramicidin D, with a tryptophan in position 11. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations. PMID:17572379 Gramicidin B is one of the three gramicidins in gramicidin D, with a phenylalanine in position 11. It is structurally similar to gramicidin A, but its ability to induce the assembly of bilayers is reduced. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations. pubchem.compound:25244501 antibiotic_resistance ARO:3000223 gramicidin B Gramicidin B is one of the three gramicidins in gramicidin D, with a phenylalanine in position 11. It is structurally similar to gramicidin A, but its ability to induce the assembly of bilayers is reduced. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations. PMID:17572379 Gramicidin C is one of the three gramicidins in gramicidin D, with a tyrosine in position 11. It is structurally similar to gramicidin A, but its ability to induce the assembly of bilayers is reduced. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations. pubchem.compound:73357 antibiotic_resistance ARO:3000224 gramicidin C Gramicidin C is one of the three gramicidins in gramicidin D, with a tyrosine in position 11. It is structurally similar to gramicidin A, but its ability to induce the assembly of bilayers is reduced. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations. PMID:17572379 A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 6-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically streptomycin, by transfer of an AMP group from an ATP substrate to the 6-hydroxyl group of the compound. antibiotic_resistance ARO:3000225 ANT(6) Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. dihydropteroate synthase antibiotic_resistance ARO:3000226 antibiotic resistant folP Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. PMID:1522070 PMID:21115799 PMID:9006040 PMID:9449266 PMID:9593127 Tyrothricin is a mixture of antibiotics including tyrocidines and gramicidins, isolated from Bacillus brevis. pubchem.compound:452550 antibiotic_resistance ARO:3000227 tyrothricin Tyrothricin is a mixture of antibiotics including tyrocidines and gramicidins, isolated from Bacillus brevis. PMID:16560680 A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 9-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically streptomycin, by transfer of an AMP group from an ATP substrate to the 9-hydroxyl group of the compound. antibiotic_resistance ARO:3000228 ANT(9) A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 4'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 4-hydroxyl group of the compound. aadD ant(4',4'') antibiotic_resistance ARO:3000229 ANT(4') Plasmid or integron-encoded nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 2'' in P. aeruginosa, K. pneumoniae, Morganella morganii, E. coli, S. typhimurium, C. freundii and A. baumannii. ANT(2'')-Ia aadB antibiotic_resistance ARO:3000230 ANT(2'')-Ia Plasmid or integron-encoded nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 2'' in P. aeruginosa, K. pneumoniae, Morganella morganii, E. coli, S. typhimurium, C. freundii and A. baumannii. PMID:25564464 PMID:3024112 ANT(2'')-Ia An operon conferring resistance to beta-lactam antibiotics. antibiotic_resistance ARO:3000231 beta-lactam resistance operon Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. antibiotic_resistance ARO:3000232 ANT(3'')-Ia Resistance to streptogramin antibiotics may be conferred through enzymatic inactivation. There are two known mechanisms of streptogramin inactivation shown clinically to confer resistance: 1) vgB lyase enzymes linearize type B streptogramin antibiotics by breaking the ester linkage; 2) vat acetyltransferase enzymes modify type A streptogramin antibiotics by transferring an acetyl group from acetyl-CoA to the secondary streptogramin hydroxyl. Both mechanisms result in antibiotic inactivation thus conferring resistance. antibiotic_resistance ARO:3000233 streptogramin inactivation enzyme Resistance to streptogramin antibiotics may be conferred through enzymatic inactivation. There are two known mechanisms of streptogramin inactivation shown clinically to confer resistance: 1) vgB lyase enzymes linearize type B streptogramin antibiotics by breaking the ester linkage; 2) vat acetyltransferase enzymes modify type A streptogramin antibiotics by transferring an acetyl group from acetyl-CoA to the secondary streptogramin hydroxyl. Both mechanisms result in antibiotic inactivation thus conferring resistance. PMID:11467949 PMID:12771141 Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics. antibiotic_resistance ARO:3000234 glycopeptide resistance gene cluster Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics. PMID:16323116 embB gene encodes for an arabinosyl transferase in the arabinogalactan synthesis pathway. It is inhibited by ethambutol. Mutations within the ERDR region of embB confers resistance to ethambutol. antibiotic_resistance ARO:3000235 ethambutol resistant embB embB gene encodes for an arabinosyl transferase in the arabinogalactan synthesis pathway. It is inhibited by ethambutol. Mutations within the ERDR region of embB confers resistance to ethambutol. PMID:21300839 PMID:21444710 PMID:9142129 This inducible cluster confers high resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. The vanA gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSHAXYZ. vanA_cluster antibiotic_resistance ARO:3000236 glycopeptide resistance gene cluster VanA This inducible cluster confers high resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. The vanA gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSHAXYZ. PMID:16323116 PMID:8380148 PMID:8843432 vanA_cluster TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. PDB:1EK9 TolC antibiotic_resistance ARO:3000237 TolC TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. PMID:10879525 PMID:11589692 PMID:12163644 PMID:14630321 PMID:16359323 TolC This inducible cluster confers resistance to vancomycin but organisms remain sensitive to teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Sensitivity to teicoplanin is due to lack of binding to the sensor kinase VanS. The vanB gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSYWHBX. vanB_cluster antibiotic_resistance ARO:3000238 glycopeptide resistance gene cluster VanB This inducible cluster confers resistance to vancomycin but organisms remain sensitive to teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Sensitivity to teicoplanin is due to lack of binding to the sensor kinase VanS. The vanB gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSYWHBX. PMID:16323116 PMID:8654967 vanB_cluster Reduction in permeability to antibiotic, generally through reduced production of porins, can provide resistance. antibiotic_resistance ARO:3000244 reduced permeability to antibiotic Reduction in permeability to antibiotic, generally through reduced production of porins, can provide resistance. PMID:19100346 PMID:2848006 RNA-polymerase binding protein which confers resistance to rifampin. RbpA antibiotic_resistance ARO:3000245 RbpA RNA-polymerase binding protein which confers resistance to rifampin. PMID:16629670 PMID:21415119 RbpA Confers low vancomycin resistance by engineering peptidoglycan precursors ending in D-Ala-D-Ser in an inducible or constitutive manner. The vanC cluster is intrinsic to the Enterococcus gallinarum chromosome. vanC organisms remain susceptible to teicoplanin. Gene orientation: vanC(XY)TRS. vanC_cluster antibiotic_resistance ARO:3000246 glycopeptide resistance gene cluster VanC Confers low vancomycin resistance by engineering peptidoglycan precursors ending in D-Ala-D-Ser in an inducible or constitutive manner. The vanC cluster is intrinsic to the Enterococcus gallinarum chromosome. vanC organisms remain susceptible to teicoplanin. Gene orientation: vanC(XY)TRS. PMID:10817725 PMID:12615855 PMID:1551598 PMID:16323116 PMID:7986009 vanC_cluster A tetrameric protein that converts phosphoenolpyruvate (PEP) to phosponopyruvate (Ppyr). PDB:1S2T Fom1 antibiotic_resistance ARO:3000247 phosphoenolpyruvate (PEP) mutase A tetrameric protein that converts phosphoenolpyruvate (PEP) to phosponopyruvate (Ppyr). PMID:15078090 DnaA is a chromosomal replication initiation protein which binds and interacts with RNA polymerase in Escherichia coli. A surplus of DnaA present in a cell has been shown to confer resistance to the antibiotic Rifampicin. Normally, rifampicin inhibits initiation of transcription by RNA polymerase, but a surplus of DnaA available at the origin has been shown to disrupt Rifampicin activity and confer resistance. DnaA antibiotic_resistance ARO:3000248 DnaA DnaA is a chromosomal replication initiation protein which binds and interacts with RNA polymerase in Escherichia coli. A surplus of DnaA present in a cell has been shown to confer resistance to the antibiotic Rifampicin. Normally, rifampicin inhibits initiation of transcription by RNA polymerase, but a surplus of DnaA available at the origin has been shown to disrupt Rifampicin activity and confer resistance. PMID:19170875 DnaA ATP-dependent kinase modifies the C-3 hydroxyl group of chloramphenicol. Source is the chloramphenicol producer Streptomyces venezuelae. antibiotic_resistance ARO:3000249 chloramphenicol phosphotransferase ATP-dependent kinase modifies the C-3 hydroxyl group of chloramphenicol. Source is the chloramphenicol producer Streptomyces venezuelae. PMID:10835366 PMID:7592948 ErmC is a methyltransferase that catalyzes the methylation of A2058 of the 23S ribosomal RNA in two steps. Expression of ErmC is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmC. ErmC ErmC' ermIM ermM antibiotic_resistance ARO:3000250 ErmC ErmC is a methyltransferase that catalyzes the methylation of A2058 of the 23S ribosomal RNA in two steps. Expression of ErmC is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmC. PMID:18439898 PMID:2113911 PMID:2492520 PMID:6792593 ErmC MsrA is an ABC-F subfamily ribosomal protection protein expressed in Staphylococcus species which confers resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. It is associated with plasmid DNA. msr(A) msrA antibiotic_resistance ARO:3000251 msrA MsrA is an ABC-F subfamily ribosomal protection protein expressed in Staphylococcus species which confers resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. It is associated with plasmid DNA. PMID:15914491 msrA Homologous to vanA, contains a D-Ala-D-Lac ligase. This cluster is constitutively expressed in the chromosome due to a dysfunctional D-ala-D-ala ligase and confers moderate resistance to both vancomycin and teicoplanin. Gene orientation: vanRSYHDX. vanD_cluster antibiotic_resistance ARO:3000253 glycopeptide resistance gene cluster VanD Homologous to vanA, contains a D-Ala-D-Lac ligase. This cluster is constitutively expressed in the chromosome due to a dysfunctional D-ala-D-ala ligase and confers moderate resistance to both vancomycin and teicoplanin. Gene orientation: vanRSYHDX. PMID:11344152 PMID:12499162 PMID:16323116 PMID:9303405 vanD_cluster emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. emrY antibiotic_resistance ARO:3000254 emrY emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. PMID:12501312 emrY Homologous to vanA, contains a D-Ala-D-Lac ligase. The vanF gene cluster is inducible and confers high resistance to vancomycin in Paenibacillus popilliae. vanF organisms remain susceptible to teicoplanin. Gene orientation: RSYZHFX. vanF_cluster antibiotic_resistance ARO:3000255 glycopeptide resistance gene cluster VanF Homologous to vanA, contains a D-Ala-D-Lac ligase. The vanF gene cluster is inducible and confers high resistance to vancomycin in Paenibacillus popilliae. vanF organisms remain susceptible to teicoplanin. Gene orientation: RSYZHFX. PMID:10681342 PMID:15980329 vanF_cluster Homologous to vanA, contains a D-Ala-D-Lac ligase. The plasmid-located vanM gene cluster is inducible and confers high resistance to vancomycin and teicoplanin. Gene orientation: RSYHMX. vanM_cluster antibiotic_resistance ARO:3000256 glycopeptide resistance gene cluster VanM Homologous to vanA, contains a D-Ala-D-Lac ligase. The plasmid-located vanM gene cluster is inducible and confers high resistance to vancomycin and teicoplanin. Gene orientation: RSYHMX. PMID:20733041 vanM_cluster Contains a D-Ala-D-Ser ligase. The vanG gene cluster is inducible and confers low resistance to vancomycin. vanG organisms remain susceptible to teicoplanin. It is the only van gene cluster that contains two vanY genes. Gene orientation: vanRSYWGYT. vanG_cluster antibiotic_resistance ARO:3000257 glycopeptide resistance gene cluster VanG Contains a D-Ala-D-Ser ligase. The vanG gene cluster is inducible and confers low resistance to vancomycin. vanG organisms remain susceptible to teicoplanin. It is the only van gene cluster that contains two vanY genes. Gene orientation: vanRSYWGYT. PMID:11036060 PMID:16323116 PMID:19851013 vanG_cluster Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanE gene cluster is inducible and confers low resistance to vancomycin. vanE organisms remain susceptible to teicoplanin. Gene orientation: E(XY)TRS. vanE_cluster antibiotic_resistance ARO:3000259 glycopeptide resistance gene cluster VanE Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanE gene cluster is inducible and confers low resistance to vancomycin. vanE organisms remain susceptible to teicoplanin. Gene orientation: E(XY)TRS. PMID:10471558 PMID:12019119 PMID:12426332 PMID:16323116 vanE_cluster Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanL gene cluster is inducible and confers low resistance to vancomycin. vanL organisms remain susceptible to teicoplanin. It is the only van gene cluster with two vanT genes. Gene orientation: vanL(XY)TmTrRS. vanL_cluster antibiotic_resistance ARO:3000260 glycopeptide resistance gene cluster VanL Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanL gene cluster is inducible and confers low resistance to vancomycin. vanL organisms remain susceptible to teicoplanin. It is the only van gene cluster with two vanT genes. Gene orientation: vanL(XY)TmTrRS. PMID:18458129 vanL_cluster When bound to different sigma factors, RNA-polymerase may possess an altered sensitivity to rifampin-mediated inhibition. antibiotic_resistance ARO:3000261 sigma factor conferring resistance to rifampin When bound to different sigma factors, RNA-polymerase may possess an altered sensitivity to rifampin-mediated inhibition. PMID:9862449 The bla operon is composed of blaZ/blaR1/blaI. antibiotic_resistance ARO:3000262 bla operon In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF. marA antibiotic_resistance ARO:3000263 marA In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF. PMID:12027588 PMID:2848006 PMID:9333027 marA EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. EmrE is found in E. coli and P. aeruginosa. antibiotic_resistance ARO:3000264 emrE EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. EmrE is found in E. coli and P. aeruginosa. PMID:12499164 PMID:17360700 PMID:17942072 PMID:17976529 PMID:18006522 PMID:19167526 PMID:19171974 In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF. antibiotic_resistance ARO:3000265 porin OmpF In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF. PMID:19100346 PMID:2848006 The inactivation of antibiotics by the enzymatic addition of ADP-ribose from NAD+. antibiotic_resistance ARO:3000266 ADP-ribosylation of antibiotic conferring resistance The mec operon is composed of mecA/mecR1/mecI. antibiotic_resistance ARO:3000268 mec operon Brodimoprim is a structural derivative of trimethoprim and an inhibitor of bacterial dihydrofolate reductase. The 4-methoxy group of trimethoprim is replaced with a bromine atom. pubchem.compound:68760 antibiotic_resistance ARO:3000269 brodimoprim Brodimoprim is a structural derivative of trimethoprim and an inhibitor of bacterial dihydrofolate reductase. The 4-methoxy group of trimethoprim is replaced with a bromine atom. PMID:10026296 PMID:7562018 PMID:8195838 Enzymes or other proteins either directly or indirectly reducing overall permeability to antibiotics. antibiotic_resistance ARO:3000270 protein modulating permeability to antibiotic Enzymes or other proteins either directly or indirectly reducing overall permeability to antibiotics. PMID:19100346 PMID:2848006 Point mutations in gyrA confer antibiotic resistance by preventing drugs from binding the alpha-subunit of gyrase, essential for DNA supercoiling. antibiotic_resistance ARO:3000273 antibiotic resistant DNA topoisomerase subunit gyrA Point mutations in parC confer antibiotic resistance by preventing drugs from binding the parC subunit of topoisomerase IV, essential for DNA decatanation and relaxation. antibiotic_resistance ARO:3000274 antibiotic resistant DNA topoisomerase subunit parC Cephems have a six-membered dihydrothiazine ring with a sulfur atom and double bond fused with its beta-lactam ring. This group includes the cephalosporins and cephamycins, the latter containing an additional alpha-methoxy group. antibiotic_resistance ARO:3000276 cephem Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway. antibiotic_resistance ARO:3000282 sulfonamide antibiotic Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway. PMID:15673783 Tetroxoprim is a trimethoprim derivative that inhibits bacterial dihydrofolate reductase. pubchem.compound:65450 antibiotic_resistance ARO:3000284 tetroxoprim Tetroxoprim is a trimethoprim derivative that inhibits bacterial dihydrofolate reductase. PMID:3043259 PMID:7036848 Stabilizes the C-P bond in phosphonopyruvate formed by phophoenolpyruvate mutase by catalyzing the self-removal of the carboxyl group. Fom2 antibiotic_resistance ARO:3000299 phosphonopyruvate decarboxylase Stabilizes the C-P bond in phosphonopyruvate formed by phophoenolpyruvate mutase by catalyzing the self-removal of the carboxyl group. PMID:10786631 LsaA is an ABC-F subfamily protein expressed in Enterococcus faecalis. It confers resistance to clindamycin, quinupristin-dalfopristin, and dalfopristin. lsaA antibiotic_resistance ARO:3000300 lsaA LsaA is an ABC-F subfamily protein expressed in Enterococcus faecalis. It confers resistance to clindamycin, quinupristin-dalfopristin, and dalfopristin. PMID:12019099 PMID:15914491 PMID:21245447 lsaA EmrD is a multidrug transporter from the Major Facilitator Superfamily (MFS) primarily found in Escherichia coli. EmrD couples efflux of amphipathic compounds with proton import across the plasma membrane. PDB:2GFP emrD antibiotic_resistance ARO:3000309 emrD EmrD is a multidrug transporter from the Major Facilitator Superfamily (MFS) primarily found in Escherichia coli. EmrD couples efflux of amphipathic compounds with proton import across the plasma membrane. PMID:16675700 PMID:16842212 PMID:8240355 PMID:8987357 emrD The mphA gene encodes for resistance enzyme MPH(2')-I which preferentially inactivate 14-membered macrolides (e.g.erythromycin, telithromycin, roxithromycin) over 16-membered macrolides (e.g.tylosin, spiramycin). It phosphorylates macrolides at 2'-OH hydroxyl of desosamine sugar of macrolides in a GTP-dependent manner. macrolide 2'-phosphotransferase I mphA antibiotic_resistance ARO:3000316 mphA The mphA gene encodes for resistance enzyme MPH(2')-I which preferentially inactivate 14-membered macrolides (e.g.erythromycin, telithromycin, roxithromycin) over 16-membered macrolides (e.g.tylosin, spiramycin). It phosphorylates macrolides at 2'-OH hydroxyl of desosamine sugar of macrolides in a GTP-dependent manner. PMID:17302923 PMID:20231391 PMID:29317655 PMID:8619599 mphA The mphB gene encodes for MPH(2')-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2'-OH hydroxyl of desosamine sugar of macrolides. macrolide 2'-phosphotransferase II mphB antibiotic_resistance ARO:3000318 mphB The mphB gene encodes for MPH(2')-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2'-OH hydroxyl of desosamine sugar of macrolides. PMID:1330822 PMID:17302923 PMID:29317655 PMID:8900063 PMID:9503630 mphB The mphC gene was identified from Staphylococcus aureus. This gene shows similarity to mphB gene from Escherchia coli. mphC antibiotic_resistance ARO:3000319 mphC The mphC gene was identified from Staphylococcus aureus. This gene shows similarity to mphB gene from Escherchia coli. PMID:12670694 PMID:17302923 PMID:29317655 mphC Hydrolytic enzymes that cleave the macrocycle lactone ring of macrolide antibiotics. antibiotic_resistance ARO:3000320 macrolide esterase Hydrolytic enzymes that cleave the macrocycle lactone ring of macrolide antibiotics. PMID:22303981 Hydrolysis of the the macrocycle lactone ring of macrolide antibiotics. antibiotic_resistance ARO:3000321 hydrolysis of macrolide macrocycle lactone ring A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. antibiotic_resistance ARO:3000322 AAC(3) A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. PMID:10639379 PMID:12709352 PMID:15388438 PMID:15728939 PMID:1577689 PMID:1649572 PMID:18467306 PMID:18476779 PMID:19709289 PMID:19949054 PMID:2060791 PMID:2549372 PMID:2914849 PMID:3892230 PMID:6318050 PMID:7486920 PMID:8257126 Sulfadiazine is a potent inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids. pubchem.compound:5215 antibiotic_resistance ARO:3000324 sulfadiazine Sulfadiazine is a potent inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids. PMID:4597736 Sulfadimidine is an alkaline sulfonamide antibiotic that inhibits dihydropteroate synthase, and enzyme in the tetrahydrofolic acid biosynthesis pathway. This interferes with the production of folate, which is a precursor to many amino acids and nucleotides. pubchem.compound:5327 sulfamethazine antibiotic_resistance ARO:3000325 sulfadimidine Sulfadimidine is an alkaline sulfonamide antibiotic that inhibits dihydropteroate synthase, and enzyme in the tetrahydrofolic acid biosynthesis pathway. This interferes with the production of folate, which is a precursor to many amino acids and nucleotides. PMID:15673783 ErmE is a methyltransferase found in the erythromycin producer Saccharopolyspora erythraea. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the erythromycin biosynthetic cluster and is responsible for self-resistance. ErmE ermE2 antibiotic_resistance ARO:3000326 ErmE ErmE is a methyltransferase found in the erythromycin producer Saccharopolyspora erythraea. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the erythromycin biosynthetic cluster and is responsible for self-resistance. PMID:12019067 PMID:3117622 PMID:7961464 PMID:9735285 PMID:9973557 ErmE Sulfadoxine is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids. pubchem.compound:17134 antibiotic_resistance ARO:3000327 sulfadoxine Sulfadoxine is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids. PMID:21029476 Single nucleotide polymorphisms (SNPs) in rRNA can confer antibiotic resistance to drugs that target the bacterial ribosome. antibiotic_resistance ARO:3000328 rRNA with mutation conferring antibiotic resistance Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides. pubchem.compound:5329 antibiotic_resistance ARO:3000329 sulfamethoxazole Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides. PMID:1093654 Sulfisoxazole is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids. pubchem.compound:5344 antibiotic_resistance ARO:3000330 sulfisoxazole Sulfisoxazole is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids. PMID:978409 Macrolide phosphotransferases (MPH) are enzymes encoded by macrolide phosphotransferase genes (mph genes). These enzymes phosphorylate macrolides in GTP dependent manner at 2'-OH of desosamine sugar thereby inactivating them. Characterized MPH's are differentiated based on their substrate specificity. antibiotic_resistance ARO:3000333 macrolide phosphotransferase (MPH) Point mutations in bacterial 23S rRNA from the large ribosomal subunit that confer resistance to antibiotics. Antibiotics such as linezolid block peptide synthesis through peptidyl transferase activity. Mutations in the 23S rRNA subunit reduce antibiotic binding affinity at specific sites, conferring resistance. antibiotic_resistance ARO:3000336 23S rRNA with mutation conferring antibiotic resistance Point mutations in bacterial 23S rRNA from the large ribosomal subunit that confer resistance to antibiotics. Antibiotics such as linezolid block peptide synthesis through peptidyl transferase activity. Mutations in the 23S rRNA subunit reduce antibiotic binding affinity at specific sites, conferring resistance. PMID:15700955 PMID:18174304 Iclaprim is a bactericidal compound that inhibits dihydrofolate reductase. It is used against clinically important Gram-positive pathogens, including methicillin-sensitive Staphylococcus aureus and methicillin-resistant S. aureus. pubchem.compound:213043 AR-100 RO-48-2622 antibiotic_resistance ARO:3000337 iclaprim Iclaprim is a bactericidal compound that inhibits dihydrofolate reductase. It is used against clinically important Gram-positive pathogens, including methicillin-sensitive Staphylococcus aureus and methicillin-resistant S. aureus. PMID:19289528 PMID:19622858 Genes that confer antibiotic resistance by hydrolyzing bonds to linearize and deactivate antibiotics. antibiotic_resistance ARO:3000338 linearization of antibiotic conferring resistance A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 2'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 2-amino group of the compound. antibiotic_resistance ARO:3000341 AAC(2') A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 2'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 2-amino group of the compound. PMID:18931120 PMID:8407825 PMID:9159528 Enzymes that inactivate fosfomycin by chemical modification. antibiotic_resistance ARO:3000342 fosfomycin inactivation enzyme Efflux pump proteins contained within Mycobacterial genomes which confer resistance to a number of different antibiotics including aminoglycosides, and tetracyclines. tap antibiotic_resistance ARO:3000343 tap Efflux pump proteins contained within Mycobacterial genomes which confer resistance to a number of different antibiotics including aminoglycosides, and tetracyclines. PMID:15057575 PMID:9811639 tap EmrAB-TolC is a multidrug efflux system found in E. coli. EmrB is the electrochemical-gradient powered transporter; EmrA is the linker; and TolC is the outer membrane channel. It confers resistance to nalidixic acid and thiolactomycin. EmrAB-TolC antibiotic_resistance ARO:3000344 EmrAB-TolC EmrAB-TolC is a multidrug efflux system found in E. coli. EmrB is the electrochemical-gradient powered transporter; EmrA is the linker; and TolC is the outer membrane channel. It confers resistance to nalidixic acid and thiolactomycin. PMID:7730261 EmrAB-TolC A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. antibiotic_resistance ARO:3000345 AAC(6') A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. PMID:15673721 ErmA confers the MLSb phenotype. Similar to ErmC, Expression of ErmA is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmA. ErmA ermTR antibiotic_resistance ARO:3000347 ErmA ErmA confers the MLSb phenotype. Similar to ErmC, Expression of ErmA is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmA. PMID:18952616 ErmA In the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic. antibiotic_resistance ARO:3000359 fosfomycin phosphotransferase In the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic. PMID:10681332 PMID:18701452 EreA is an erythromycin esterase that hydrolyses the drug's lactone ring. Ere(A) EreA antibiotic_resistance ARO:3000361 EreA EreA is an erythromycin esterase that hydrolyses the drug's lactone ring. PMID:22303981 EreA EreB is an erythromycin esterase-like protein that hydrolyses the drug's lactone ring. Ere(B) EreB antibiotic_resistance ARO:3000363 EreB EreB is an erythromycin esterase-like protein that hydrolyses the drug's lactone ring. PMID:10908116 EreB VanC is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is specific to Enterococcus gallinarum and E. casseliflavus, providing intrinsic resistance. vanC antibiotic_resistance ARO:3000368 vanC VanC is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is specific to Enterococcus gallinarum and E. casseliflavus, providing intrinsic resistance. PMID:1551598 PMID:16323116 PMID:9666008 vanC The mtr (multiple transferable resistance) system of Neisseria gonorrhoeae confers resistance to many hydrophobic agents including antibiotics, fatty-acids and detergents. MtrCDE is homologous to AcrAB-TolC, where MtrC is the membrane fusion protein, MtrD is the inner membrane transporter, and MtrE is the outer membrane channel protein. MtrCDE antibiotic_resistance ARO:3000369 MtrCDE The mtr (multiple transferable resistance) system of Neisseria gonorrhoeae confers resistance to many hydrophobic agents including antibiotics, fatty-acids and detergents. MtrCDE is homologous to AcrAB-TolC, where MtrC is the membrane fusion protein, MtrD is the inner membrane transporter, and MtrE is the outer membrane channel protein. PMID:14500476 PMID:7711899 MtrCDE Many drugs target topoisomerases to inhibit DNA synthesis. Resistant DNA topoisomerase subunits prevent antibiotic binding and thus confer resistance. antibiotic_resistance ARO:3000370 antibiotic resistant DNA topoisomerase subunit VanT is a membrane bound serine racemase, converting L-serine to D-serine. It is associated with VanC, which incorporated D-serine into D-Ala-D-Ser terminal end of peptidoglycan subunits that have a decreased binding affinity with vancomycin. It was isolated from Enterococcus gallinarum. antibiotic_resistance ARO:3000372 vanT VanT is a membrane bound serine racemase, converting L-serine to D-serine. It is associated with VanC, which incorporated D-serine into D-Ala-D-Ser terminal end of peptidoglycan subunits that have a decreased binding affinity with vancomycin. It was isolated from Enterococcus gallinarum. PMID:10817725 PMID:10878136 EmrKY is a homolog of EmrAB found in E. coli. Together with TolC, it is a tripartite multidrug transporter. EmrKY-TolC antibiotic_resistance ARO:3000373 EmrKY-TolC EmrKY is a homolog of EmrAB found in E. coli. Together with TolC, it is a tripartite multidrug transporter. PMID:12501312 PMID:21954395 EmrKY-TolC ErmB confers the MLSb phenotype. Similar to ErmC, expression of ErmB is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmB. PDB:1YUB ErmB erm erm2 ermAM ermAMR ermBC ermBP ermBZ1 ermBZ2 ermIP ermP antibiotic_resistance ARO:3000375 ErmB ErmB confers the MLSb phenotype. Similar to ErmC, expression of ErmB is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmB. PMID:10508434 PMID:18299414 PMID:9187657 ErmB vgb (Virginiamycin B) lyase inactivates type B streptogramin antibiotics by linearizing the streptogramin lactone ring at the ester linkage through an elimination mechanism, thus conferring resistance to these compounds. antibiotic_resistance ARO:3000376 streptogramin vgb lyase vgb (Virginiamycin B) lyase inactivates type B streptogramin antibiotics by linearizing the streptogramin lactone ring at the ester linkage through an elimination mechanism, thus conferring resistance to these compounds. PMID:11467949 MexA is the membrane fusion protein of the MexAB-OprM multidrug efflux complex. PDB:1T5E MexA antibiotic_resistance ARO:3000377 MexA MexA is the membrane fusion protein of the MexAB-OprM multidrug efflux complex. PMID:15117957 MexA MexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM. PDB:2V50 MexB antibiotic_resistance ARO:3000378 MexB MexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM. PMID:14973037 PMID:19361527 PMID:20583998 PMID:21178960 MexB OprM is an outer membrane factor protein found in Pseudomonas aeruginosa and Burkholderia vietnamiensis. It is part of the MexAB-OprM, MexVW-OprM, MexXY-OprM and the AmrAB-OprM complex. PDB:1WP1 OprM antibiotic_resistance ARO:3000379 OprM OprM is an outer membrane factor protein found in Pseudomonas aeruginosa and Burkholderia vietnamiensis. It is part of the MexAB-OprM, MexVW-OprM, MexXY-OprM and the AmrAB-OprM complex. PMID:15797729 PMID:16508113 PMID:16511029 OprM FosC is an enzyme that phosphorylates fosfomycin to confer resistance. FosC antibiotic_resistance ARO:3000380 FosC FosC is an enzyme that phosphorylates fosfomycin to confer resistance. PMID:7492106 FosC Alternate proteins that have the same functions as other antibiotic target proteins, but are structurally different and thus resistant to antibiotics. These can replace the activity of other antibiotic-sensitive proteins in the presence of antibiotics. antibiotic_resistance ARO:3000381 antibiotic target replacement protein Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit. pubchem.compound:62858 antibiotic_resistance ARO:3000382 azidamfenicol Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit. PMID:15539072 AcrAB-TolC is a tripartite RND efflux system that confers resistance to tetracycline, chloramphenicol, ampicillin, nalidixic acid, and rifampin in Gram-negative bacteria. The system spans the cell membrane (AcrB) and the outer-membrane (TolC), and is linked together in the periplasm by AcrA. AcrAB-TolC antibiotic_resistance ARO:3000384 AcrAB-TolC AcrAB-TolC is a tripartite RND efflux system that confers resistance to tetracycline, chloramphenicol, ampicillin, nalidixic acid, and rifampin in Gram-negative bacteria. The system spans the cell membrane (AcrB) and the outer-membrane (TolC), and is linked together in the periplasm by AcrA. PMID:21513882 PMID:8550435 AcrAB-TolC Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation. pubchem.compound:5959 CHL antibiotic_resistance ARO:3000385 chloramphenicol Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation. PMID:17737966 MexAB-OprM is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexA is the membrane fusion protein; MexB is the inner membrane transporter; and OprM is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, erythromycin, azithromycin, novobiocin, and certain β-lactams and lastly over-expression is linked to colistin resistance. antibiotic_resistance ARO:3000386 MexAB-OprM MexAB-OprM is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexA is the membrane fusion protein; MexB is the inner membrane transporter; and OprM is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, erythromycin, azithromycin, novobiocin, and certain β-lactams and lastly over-expression is linked to colistin resistance. PMID:16189126 PMID:17586626 PMID:18312276 PMID:18676884 PMID:9449262 Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome. phenicol antibiotic_resistance ARO:3000387 phenicol antibiotic Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome. PMID:12860128 Biosynthesis of streptoramin antibiotics. antibiotic_resistance ARO:3000388 streptogramin biosynthesis Type B streptogramins are cyclic hexa- or hepta-depsipeptides produced by NRPSs in Streptomyces. The NRPS contains 6 or 7 modules arranged on one or more genes. SnbA catalyzes the activation of the first residue, 3-hydroxypicolynic acid. SnbC then activates and incorporates threonine and aminobutyric acid. Lastly, SnbDE activates and incoporates the last four amino acids. The thioesterase domain is responsible for peptide cyclization, and it is located at the end of the assembly line. antibiotic_resistance ARO:3000389 streptogramin B biosynthesis Type B streptogramins are cyclic hexa- or hepta-depsipeptides produced by NRPSs in Streptomyces. The NRPS contains 6 or 7 modules arranged on one or more genes. SnbA catalyzes the activation of the first residue, 3-hydroxypicolynic acid. SnbC then activates and incorporates threonine and aminobutyric acid. Lastly, SnbDE activates and incoporates the last four amino acids. The thioesterase domain is responsible for peptide cyclization, and it is located at the end of the assembly line. PMID:900602 PMID:9006023 PMID:9303382 Enzyme responsible for the ADP-ribosylative inactivation of rifampin at the 23-OH position using NAD+. antibiotic_resistance ARO:3000390 rifampin ADP-ribosyltransferase (Arr) Enzyme responsible for the ADP-ribosylative inactivation of rifampin at the 23-OH position using NAD+. PMID:18349144 PMID:9869590 NorA is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like acriflavine. It shares 30% similarity with NorA, and is a structural homolog of Bmr of Bacillus subtilis. It is regulated by arlRS and mgrA, the latter also known as NorR. norA antibiotic_resistance ARO:3000391 norA NorA is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like acriflavine. It shares 30% similarity with NorA, and is a structural homolog of Bmr of Bacillus subtilis. It is regulated by arlRS and mgrA, the latter also known as NorR. PMID:12730173 PMID:15774883 PMID:8431010 norA Erm(37) is found in Mycobacterium species and confers the MLSb phenotype. In addition to methylation of A2058 this Erm methylates adjacent adenosines (A2057 and A2059) as well. Erm(37) Erm37 antibiotic_resistance ARO:3000392 Erm(37) Erm(37) is found in Mycobacterium species and confers the MLSb phenotype. In addition to methylation of A2058 this Erm methylates adjacent adenosines (A2057 and A2059) as well. PMID:14693532 PMID:16174779 Erm(37) Synthesis of glycopeptide antibiotics. antibiotic_resistance ARO:3000393 glycopeptide biosynthesis Biosynthesis of teicoplanin by Actinoplanes teichomyceticus. antibiotic_resistance ARO:3000394 Actinoplanes teichomyceticus teicoplanin gene cluster Biosynthesis of teicoplanin by Actinoplanes teichomyceticus. PMID:15113000 Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons. sul1 antibiotic_resistance ARO:3000410 sul1 Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons. PMID:11432417 PMID:17158944 PMID:17827139 PMID:18753343 PMID:19075060 PMID:21537009 sul1 Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria, usually found on small plasmids. sul2 antibiotic_resistance ARO:3000412 sul2 Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria, usually found on small plasmids. PMID:11432417 PMID:15722395 sul2 Sul3 is a sulfonamide resistant dihydropteroate synthase similar to Sul1 and Sul2. Its resistance gene was found encoded in E. coli plasmid DNA of sulfonamide resistant isolates. sul3 antibiotic_resistance ARO:3000413 sul3 Sul3 is a sulfonamide resistant dihydropteroate synthase similar to Sul1 and Sul2. Its resistance gene was found encoded in E. coli plasmid DNA of sulfonamide resistant isolates. PMID:12604565 sul3 Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. Qnr antibiotic_resistance ARO:3000419 quinolone resistance protein (qnr) Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. PMID:15933203 PMID:19258263 PMID:19822894 NorB is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 30% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. It is regulated by mgrA, also known as NorR. norB antibiotic_resistance ARO:3000421 norB NorB is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 30% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. It is regulated by mgrA, also known as NorR. PMID:15774883 norB In the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic. PDB:3D40 FomA antibiotic_resistance ARO:3000423 FomA In the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic. PMID:10681332 PMID:18701452 FomA The enzymatic inactivation of rifampin by glycosylation at the 23-OH position. antibiotic_resistance ARO:3000443 rifampin glycosyltransferase The enzymatic inactivation of rifampin by glycosylation at the 23-OH position. PMID:22802246 PMID:8328779 The enzymatic inactivation of rifampin by phosphorylation at the 21-OH position. rphA antibiotic_resistance ARO:3000444 rphA The enzymatic inactivation of rifampin by phosphorylation at the 21-OH position. PMID:24778229 PMID:27103605 PMID:7928806 rphA Enzyme responsible for the decolorization of rifampin by monoxygenation. antibiotic_resistance ARO:3000445 rifampin monooxygenase Enzyme responsible for the decolorization of rifampin by monoxygenation. PMID:19942945 PMID:8980786 Mupirocin inhibits protein synthesis by interfering with isoleucyl-tRNA synthetase (ileS). Mutations in ileS can confer low-level mupirocin resistance. antibiotic_resistance ARO:3000446 antibiotic-resistant isoleucyl-tRNA synthetase (ileS) Mupirocin inhibits protein synthesis by interfering with isoleucyl-tRNA synthetase (ileS). Mutations in ileS can confer low-level mupirocin resistance. PMID:11599741 PMID:11796355 PMID:21421794 PMID:22252810 PMID:8067768 QepA1 is a plasmid-mediated efflux pump in E. coli, shown to contribute to fluoroquinolone resistance. It is regulated by sox genes, also known as global stress regulators. QepA QepA1 antibiotic_resistance ARO:3000448 QepA1 QepA1 is a plasmid-mediated efflux pump in E. coli, shown to contribute to fluoroquinolone resistance. It is regulated by sox genes, also known as global stress regulators. PMID:17548499 QepA1 An enzyme which on its own cannot provide fosfomycin resistance, however in conjunction with FomA, it leads to the formation of fosfomycin with three phosphates total, which makes it inactive. FomB antibiotic_resistance ARO:3000449 FomB An enzyme which on its own cannot provide fosfomycin resistance, however in conjunction with FomA, it leads to the formation of fosfomycin with three phosphates total, which makes it inactive. PMID:18701452 FomB Inactivation of an antibiotic via introduction a hydroxyl group (-OH). antibiotic_resistance ARO:3000450 hydroxylation of antibiotic conferring resistance Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux. antibiotic_resistance ARO:3000451 protein(s) and two-component regulatory system modulating antibiotic efflux Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux. PMID:14572535 PMID:24878531 Fluoroquinolones inhibit type II and type IV topoisomerases (2 strand breaking enzymes) such as GyrA/GyrB and ParC/ParE. Point mutations in the associated gyrA and parC genes, in particular in the 'quinolone resistance determining region' (QRDR), give rise to resistance to the class. antibiotic_resistance ARO:3000452 fluoroquinolone resistant DNA topoisomerase Fluoroquinolones inhibit type II and type IV topoisomerases (2 strand breaking enzymes) such as GyrA/GyrB and ParC/ParE. Point mutations in the associated gyrA and parC genes, in particular in the 'quinolone resistance determining region' (QRDR), give rise to resistance to the class. PMID:11504468 PMID:20802486 PMID:22279180 vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds. Streptogramin A acetyltransferase (SAT) antibiotic_resistance ARO:3000453 streptogramin vat acetyltransferase vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds. PMID:11841212 PMID:12771141 PMID:20713681 Polymyxin B is mixture of mostly polymyxins B1 and B2, mainly used for resistant gram-negative infections. They are polypeptides with cationic detergent action on cell membranes. pubchem.compound:49800004 antibiotic_resistance ARO:3000454 polymyxin B Polymyxin B is mixture of mostly polymyxins B1 and B2, mainly used for resistant gram-negative infections. They are polypeptides with cationic detergent action on cell membranes. PMID:17201926 Type A streptogramins are produced by a hybrid NRPS/PKS composed of 8 NRPS modules and 2 PKS modules. antibiotic_resistance ARO:3000455 streptogramin A biosynthesis Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3). pubchem.compound:27200 antibiotic_resistance ARO:3000456 thiamphenicol Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3). PMID:15539072 ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParE prevent anticoumarin antibiotics from inhibiting DNA synthesis, thus conferring resistance. antibiotic_resistance ARO:3000457 aminocoumarin resistant parE ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParE prevent anticoumarin antibiotics from inhibiting DNA synthesis, thus conferring resistance. PMID:16127057 Macrolide glycosyltransferases are enzymes encoded by macrolide glycosyltransferase genes and inactivate macrolides by glycosylating them at 2'-OH of desosamine sugar moiety. They are predominantly found in macrolide producers and are also found in non-producers and are used as a resistance mechanism. Different variants of this enzyme has been reported. antibiotic_resistance ARO:3000458 macrolide glycosyltransferase Macrolide glycosyltransferases are enzymes encoded by macrolide glycosyltransferase genes and inactivate macrolides by glycosylating them at 2'-OH of desosamine sugar moiety. They are predominantly found in macrolide producers and are also found in non-producers and are used as a resistance mechanism. Different variants of this enzyme has been reported. PMID:17376874 Biosynthesis of fosfomycin. antibiotic_resistance ARO:3000459 fosfomycin biosynthesis Florfenicol is a fluorine derivative of chloramphenicol, where the nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3) and the hydroxyl group (-OH), by a fluorine group (-F). The action mechanism is the same as chloramphenicol's, where the antibiotic binds to the 23S RNA of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. pubchem.compound:114811 antibiotic_resistance ARO:3000461 florfenicol Florfenicol is a fluorine derivative of chloramphenicol, where the nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3) and the hydroxyl group (-OH), by a fluorine group (-F). The action mechanism is the same as chloramphenicol's, where the antibiotic binds to the 23S RNA of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. PMID:15539072 A macrolide glycosyltransferase encoded by the mgtA gene in Streptomyces lividans. This enzyme inactivates macrolides using UDP-glucose as a cofactor. Its optimal substrates are lankamycin, calcomycin, rosaramicin, methymycin, and pikromycin, while interactions with erythomycin, oldeandomycin, azithromycin, and tylosin were weaker. It is inactive against spiramycin and carbomycin. Mechanism first described by Cundliffe, 1992. mgt mgtA antibiotic_resistance ARO:3000462 mgtA A macrolide glycosyltransferase encoded by the mgtA gene in Streptomyces lividans. This enzyme inactivates macrolides using UDP-glucose as a cofactor. Its optimal substrates are lankamycin, calcomycin, rosaramicin, methymycin, and pikromycin, while interactions with erythomycin, oldeandomycin, azithromycin, and tylosin were weaker. It is inactive against spiramycin and carbomycin. Mechanism first described by Cundliffe, 1992. PMID:1605601 PMID:1612452 mgtA A macrolide glycosyltransferase encoded by the gimA gene in Streptomyces ambofaciens, a natural producer of the macrolide antibiotic spiramycin. Chalcomycin, methymycin, tylosin, pikromycin, rosaramicin, oleandomycin, josamycin, and carbomycin are preferred substrates of gimA glycosyltransferase, while erythromycin and spiramycin have notably low binding affinities. GimA may be able to inactivate spiramycin precursors. Described by Gourmelen et al. 1998. gimA antibiotic_resistance ARO:3000463 gimA A macrolide glycosyltransferase encoded by the gimA gene in Streptomyces ambofaciens, a natural producer of the macrolide antibiotic spiramycin. Chalcomycin, methymycin, tylosin, pikromycin, rosaramicin, oleandomycin, josamycin, and carbomycin are preferred substrates of gimA glycosyltransferase, while erythromycin and spiramycin have notably low binding affinities. GimA may be able to inactivate spiramycin precursors. Described by Gourmelen et al. 1998. PMID:9756764 gimA Mutant forms of the porin Por result in reduced permeability to antibiotics, particularly tetracyclines and beta-lactams. Ngon_porin antibiotic_resistance ARO:3000464 Neisseria gonorrhoeae porin PIB (por) Mutant forms of the porin Por result in reduced permeability to antibiotics, particularly tetracyclines and beta-lactams. PMID:12183233 PMID:16547016 PMID:9797206 Ngon_porin OleI and OleD are glycosyltransferases found in Streptomyces antibioticus which is a natural producer of antibiotic oleandomycin. OleI glycosylates antibiotic oleandomycin whereas OleD can glycosylate a wide variety of macrolides. antibiotic_resistance ARO:3000465 ole glycosyltransferase OleI and OleD are glycosyltransferases found in Streptomyces antibioticus which is a natural producer of antibiotic oleandomycin. OleI glycosylates antibiotic oleandomycin whereas OleD can glycosylate a wide variety of macrolides. PMID:15984838 PMID:17376874 PMID:9680207 Dalbavancin is a semisynthetic second-generation lipoglycopeptide derived from teicoplanin. It binds to the D-Ala-D-Ala terminus of peptidoglycan precursors. It is used to treat Gram-positive bacteria and can be used to treat methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. pubchem.compound:23724878 Zeven antibiotic_resistance ARO:3000466 dalbavancin Dalbavancin is a semisynthetic second-generation lipoglycopeptide derived from teicoplanin. It binds to the D-Ala-D-Ala terminus of peptidoglycan precursors. It is used to treat Gram-positive bacteria and can be used to treat methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. PMID:15566329 PMID:17461743 PMID:27904526 New Delhi beta-lactamase NDM-5. NDM-5 antibiotic_resistance ARO:3000467 NDM-5 New Delhi beta-lactamase NDM-5. PMID:21930874 NDM-5 The enzyme responsible for the final step of fosfomycin biosynthesis. It converts S-2-hydroxypropylphosphonic acid (S-HPP) into fosfomycin via an oxidative cyclalization reaction. It uses Iron (II) or Zinc (II) as cofactors. PDB:1ZZ6 Fom4 HppE antibiotic_resistance ARO:3000469 hydroxypropylphosphonic acid epoxidase The enzyme responsible for the final step of fosfomycin biosynthesis. It converts S-2-hydroxypropylphosphonic acid (S-HPP) into fosfomycin via an oxidative cyclalization reaction. It uses Iron (II) or Zinc (II) as cofactors. PMID:16015285 PMID:16186494 Tet31 is a tetracycline efflux pump found in Aeromonas salmonicida, a Gram-negative bacteria. It has also been shown to be expressed in Gallibacterium anatis. tet(31) tet31 antibiotic_resistance ARO:3000476 tet(31) Tet31 is a tetracycline efflux pump found in Aeromonas salmonicida, a Gram-negative bacteria. It has also been shown to be expressed in Gallibacterium anatis. PMID:11381101 PMID:12383729 PMID:21145184 tet(31) Tet33 is a tetracycline efflux pump found in Gram-positive bacteria, including Arthrobacter and Corynebacterium. tet(33) tet33 tetA(33) antibiotic_resistance ARO:3000478 tet(33) Tet33 is a tetracycline efflux pump found in Gram-positive bacteria, including Arthrobacter and Corynebacterium. PMID:12383729 tet(33) Point mutations in DNA gyrase subunit B (gyrB) can result in resistance to aminocoumarins. These mutations usually involve arginine residues in organisms. antibiotic_resistance ARO:3000479 aminocoumarin resistant gyrB Point mutations in DNA gyrase subunit B (gyrB) can result in resistance to aminocoumarins. These mutations usually involve arginine residues in organisms. PMID:12604514 PMID:14993313 PMID:16868863 PMID:21693461 PMID:21996946 PMID:9797224 Expression of parY(R), which encodes an aminocoumarin resistant topoisomerase IV, can confer aminocoumarin resistance. antibiotic_resistance ARO:3000480 aminocoumarin resistant parY Expression of parY(R), which encodes an aminocoumarin resistant topoisomerase IV, can confer aminocoumarin resistance. PMID:12604514 PMID:14993313 PMID:16868863 Tet35 is a tetracycline efflux pump found in the Gram-negative Vibrio and Stenotrophomonas. It is unrelated to other tet resistance genes. effJ tet(35) tet35 antibiotic_resistance ARO:3000481 tet(35) Tet35 is a tetracycline efflux pump found in the Gram-negative Vibrio and Stenotrophomonas. It is unrelated to other tet resistance genes. PMID:11897587 tet(35) Telavancin is a semi-synthetic derivative of vancomycin and is a second-generation lipoglycopeptide antibiotic. Telavancin inhibits cell wall synthesis by forming a complex with the D-Ala-D-Ala terminus of peptidoglycan precursors and preventing transglycosylation. pubchem.compound:3081362 antibiotic_resistance ARO:3000488 telavancin Telavancin is a semi-synthetic derivative of vancomycin and is a second-generation lipoglycopeptide antibiotic. Telavancin inhibits cell wall synthesis by forming a complex with the D-Ala-D-Ala terminus of peptidoglycan precursors and preventing transglycosylation. PMID:18671473 PMID:19401479 PMID:19436839 Sav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil, tetraphenylphosphorchloride, and Hoechst 33342. PDB:2HYD sav1866 antibiotic_resistance ARO:3000489 sav1866 Sav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil, tetraphenylphosphorchloride, and Hoechst 33342. PMID:16943773 PMID:17303126 sav1866 Tuberactinomycins are a family of cyclic peptide antibiotics that are important in the treatment of tuberculosis. Tuberactinomycins contain nonproteinogenic amino acids and inhibit group I self-splicing RNA to disrupt prokaryotic protein synthesis. pubchem.compound:24847446 antibiotic_resistance ARO:3000490 tuberactinomycin Tuberactinomycins are a family of cyclic peptide antibiotics that are important in the treatment of tuberculosis. Tuberactinomycins contain nonproteinogenic amino acids and inhibit group I self-splicing RNA to disrupt prokaryotic protein synthesis. PMID:12936980 PMID:7509881 AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole, and is regulated by baeRS and cpxAR. acrD antibiotic_resistance ARO:3000491 acrD AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole, and is regulated by baeRS and cpxAR. PMID:10692383 acrD Genes that are involved in conferring self resistance to antibiotic. antibiotic_resistance ARO:3000492 gene involved in self-resistance to antibiotic Genes that are involved in conferring self resistance to antibiotic. PMID:16186494 ErmD confers MLSb phenotype. ErmD ermJ ermK antibiotic_resistance ARO:3000495 ErmD ErmD confers MLSb phenotype. PMID:26650381 ErmD VanXY is a protein with both D,D-carboxypeptidase and D,D-dipeptidase activity, found in Enterococcus gallinarum. It cleaves and removes the terminal D-Ala of peptidoglycan subunits for the incorporation of D-Ser by VanC. D-Ala-D-Ser has low binding affinity with vancomycin. antibiotic_resistance ARO:3000496 vanXY VanXY is a protein with both D,D-carboxypeptidase and D,D-dipeptidase activity, found in Enterococcus gallinarum. It cleaves and removes the terminal D-Ala of peptidoglycan subunits for the incorporation of D-Ser by VanC. D-Ala-D-Ser has low binding affinity with vancomycin. PMID:10564477 Ethambutol is an antimycobacterial drug prescribed to treat tuberculosis. It is usually given in combination with other tuberculosis drugs, such as isoniazid, rifampicin, and pyrazinamide. Ethambutol inhibits arabinosyl biosynthesis, disrupting mycobacterial cell wall formation. pubchem.compound:14052 antibiotic_resistance ARO:3000497 ethambutol Ethambutol is an antimycobacterial drug prescribed to treat tuberculosis. It is usually given in combination with other tuberculosis drugs, such as isoniazid, rifampicin, and pyrazinamide. Ethambutol inhibits arabinosyl biosynthesis, disrupting mycobacterial cell wall formation. PMID:18242089 ErmF confers the MLSb phenotype. ErmF ermFS ermFU antibiotic_resistance ARO:3000498 ErmF ErmF confers the MLSb phenotype. PMID:26219215 ErmF AcrE is a membrane fusion protein, similar to AcrA. AcrE antibiotic_resistance ARO:3000499 AcrE AcrE is a membrane fusion protein, similar to AcrA. PMID:16267305 PMID:8407802 AcrE The enzyme responsible for converting phosphonoacetaldehyde to (S)-2-/nhydroxypropylphosphonic acid (S-HPP) via an anionic methyl attack, which also reduces the aldehyde to an alcohol. Fom3 antibiotic_resistance ARO:3000500 phosphonoacetaldehyde methyltransfererase The enzyme responsible for converting phosphonoacetaldehyde to (S)-2-/nhydroxypropylphosphonic acid (S-HPP) via an anionic methyl attack, which also reduces the aldehyde to an alcohol. PMID:1468993 PMID:16015285 Due to gene duplication, the genomes of Nocardia species include both rifampin-sensitive beta-subunit of RNA polymerase (rpoB) and rifampin-resistant beta-subunit of RNA polymerase (rpoB2) genes, with ~88% similarity between the two gene products. Expression of the rpoB2 variant results in replacement of rifampin sensitivity with rifampin resistance. rpoB2 antibiotic_resistance ARO:3000501 rpoB2 Due to gene duplication, the genomes of Nocardia species include both rifampin-sensitive beta-subunit of RNA polymerase (rpoB) and rifampin-resistant beta-subunit of RNA polymerase (rpoB2) genes, with ~88% similarity between the two gene products. Expression of the rpoB2 variant results in replacement of rifampin sensitivity with rifampin resistance. PMID:16569850 rpoB2 AcrF is a inner membrane transporter, similar to AcrB. AcrF antibiotic_resistance ARO:3000502 AcrF AcrF is a inner membrane transporter, similar to AcrB. PMID:16267305 AcrF AcrEF-TolC is a tripartite multidrug efflux system similar to AcrAB-TolC and found in Gram-negative bacteria. AcrE is the membrane fusion protein, AcrF is the inner membrane transporter, and TolC is the outer membrane channel protein. EnvCD-TolC antibiotic_resistance ARO:3000503 AcrEF-TolC AcrEF-TolC is a tripartite multidrug efflux system similar to AcrAB-TolC and found in Gram-negative bacteria. AcrE is the membrane fusion protein, AcrF is the inner membrane transporter, and TolC is the outer membrane channel protein. PMID:12937021 PMID:16267305 PMID:1720861 PMID:18984645 PMID:8647368 GolS is a regulator activated by the presence of golD, and promotes the expression of the MdsABC efflux pump. golS antibiotic_resistance ARO:3000504 golS GolS is a regulator activated by the presence of golD, and promotes the expression of the MdsABC efflux pump. PMID:17919284 PMID:20807206 golS MexR is the repressor of the MexRAB-OprM operon. Mutant forms of mexR result in up-regulation of efflux pump system MexAB-OprM. PDB:1LNW MexR nalB antibiotic_resistance ARO:3000506 MexR MexR is the repressor of the MexRAB-OprM operon. Mutant forms of mexR result in up-regulation of efflux pump system MexAB-OprM. PMID:12727072 PMID:14526032 PMID:18812515 PMID:20616806 MexR Proteins which have been experimentally shown to protect RNA-polymerase from rifampin inhibition. antibiotic_resistance ARO:3000507 rifampin-resistant RNA polymerase-binding protein GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. gadX antibiotic_resistance ARO:3000508 gadX GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. PMID:18297445 gadX An alternative isoleucyl-tRNA synthetase conferring resistance to mupirocin. Saur_mupB_MUP antibiotic_resistance ARO:3000510 Staphylococcus aureus mupB conferring resistance to mupirocin An alternative isoleucyl-tRNA synthetase conferring resistance to mupirocin. PMID:22252810 Saur_mupB_MUP EvgSA is a two-component regulatory system that regulates MdtEF and EmrKY expression for multidrug resistance. EvgS is a sensor protein that phosphorylates the regulatory protein EvgA, though EvgA can be phosphorylated by other methods when it is overexpressed. antibiotic_resistance ARO:3000515 evgSA EvgSA is a two-component regulatory system that regulates MdtEF and EmrKY expression for multidrug resistance. EvgS is a sensor protein that phosphorylates the regulatory protein EvgA, though EvgA can be phosphorylated by other methods when it is overexpressed. PMID:11914367 EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. emrR mprA antibiotic_resistance ARO:3000516 emrR EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. PMID:7730261 emrR Rifaximin is a semi-synthetic rifamycin used to treat traveller's diarrhea. Rifaximin inhibits RNA synthesis by binding to the beta subunit of bacterial RNA polymerase. pubchem.compound:6436173 antibiotic_resistance ARO:3000517 rifaximin Rifaximin is a semi-synthetic rifamycin used to treat traveller's diarrhea. Rifaximin inhibits RNA synthesis by binding to the beta subunit of bacterial RNA polymerase. PMID:15667909 CRP is a global regulator that represses MdtEF multidrug efflux pump expression. CRP antibiotic_resistance ARO:3000518 CRP CRP is a global regulator that represses MdtEF multidrug efflux pump expression. PMID:18503189 CRP Enzymes that confer resistance by modifying antibiotic targets. antibiotic_resistance ARO:3000519 antibiotic target modifying enzyme Isoniazid is an organic compound that is the first-line anti tuberculosis medication in prevention and treatment. As a prodrug, it is activated by mycobacterial catalase-peroxidases such as M. tuberculosis KatG. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. pubchem.compound:3767 antibiotic_resistance ARO:3000520 isoniazid Isoniazid is an organic compound that is the first-line anti tuberculosis medication in prevention and treatment. As a prodrug, it is activated by mycobacterial catalase-peroxidases such as M. tuberculosis KatG. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. PMID:19139099 PMID:8143118 An alternative isoleucyl-tRNA synthetase conferring resistance to mupirocin. Saur_mupA_MUP ileS2 antibiotic_resistance ARO:3000521 Staphylococcus aureus mupA conferring resistance to mupirocin An alternative isoleucyl-tRNA synthetase conferring resistance to mupirocin. PMID:11599741 PMID:21421794 PMID:8067768 Saur_mupA_MUP ErmG is a rRNA adenine N-6-methyltransferase that protects the ribosome from inactivation due to antibiotic binding. ErmG antibiotic_resistance ARO:3000522 ErmG ErmG is a rRNA adenine N-6-methyltransferase that protects the ribosome from inactivation due to antibiotic binding. PMID:3025178 ErmG CpxAR is a two-component regulatory system that involves a sensor kinase, CpxA, and the regulator CpxR. When the membrane envelope is stressed, CpxAR promotes acrD and mdtABC expression to confer multidrug resistance through efflux. antibiotic_resistance ARO:3000524 cpxAR CpxAR is a two-component regulatory system that involves a sensor kinase, CpxA, and the regulator CpxR. When the membrane envelope is stressed, CpxAR promotes acrD and mdtABC expression to confer multidrug resistance through efflux. PMID:12618449 PMID:22496764 A40926 is a glycopeptide antibiotic produced by Nonomuraea sp. ATCC 39727. It is precusor of the second-generation glycopeptide antibiotic dalbavancin. pubchem.compound:16133962 antibiotic_resistance ARO:3000525 antibiotic A40926 A40926 is a glycopeptide antibiotic produced by Nonomuraea sp. ATCC 39727. It is precusor of the second-generation glycopeptide antibiotic dalbavancin. PMID:12837387 PMID:15664522 CmeR is a repressor for the CmeABC multidrug efflux pump, binding to the cmeABC promoter region. cmeR antibiotic_resistance ARO:3000526 cmeR CmeR is a repressor for the CmeABC multidrug efflux pump, binding to the cmeABC promoter region. PMID:15728904 cmeR Polyamine antibiotics are organic compounds having two or more primary amino groups. antibiotic_resistance ARO:3000527 polyamine antibiotic Chlortetracycline was an early, first-generation tetracycline antibiotic developed in the 1940's. It inhibits bacterial protein synthesis by binding to the 30S subunit of bacterial ribosomes, preventing the aminoacyl-tRNA from binding to the ribosome. pubchem.compound:54675777 Aureomycin Eremomycine antibiotic_resistance ARO:3000528 chlortetracycline Chlortetracycline was an early, first-generation tetracycline antibiotic developed in the 1940's. It inhibits bacterial protein synthesis by binding to the 30S subunit of bacterial ribosomes, preventing the aminoacyl-tRNA from binding to the ribosome. PMID:11381101 PMID:19862477 Rifabutin is a semisynthetic rifamycin used in tuberculosis therapy. It inhibits DNA-dependent RNA synthesis. pubchem.compound:135398743 antibiotic_resistance ARO:3000530 rifabutin Rifabutin is a semisynthetic rifamycin used in tuberculosis therapy. It inhibits DNA-dependent RNA synthesis. PMID:15700959 BaeSR is a two component regulatory system for efflux proteins in Gram-negative bacteria. BaeR is a response regulator, while BaeS is a sensor kinase. antibiotic_resistance ARO:3000531 baeSR BaeSR is a two component regulatory system for efflux proteins in Gram-negative bacteria. BaeR is a response regulator, while BaeS is a sensor kinase. PMID:12107134 PMID:15716448 Biosynthesis of aminocoumarin antibiotics. antibiotic_resistance ARO:3000532 aminocoumarin biosynthesis Biosynthesis of aminocoumarin antibiotics. PMID:16868863 MacA is a membrane fusion protein that forms an antibiotic efflux complex with MacB and TolC. macA corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PDB:3FPP macA pvdR antibiotic_resistance ARO:3000533 macA MacA is a membrane fusion protein that forms an antibiotic efflux complex with MacB and TolC. macA corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PMID:19254725 PMID:20307498 macA Rifapentine is a semisynthetic rifamycin that inhibits DNA-dependent RNA synthesis. It is often used in the treatment of tuberculosis and leprosy. pubchem.compound:135403821 priftin antibiotic_resistance ARO:3000534 rifapentine Rifapentine is a semisynthetic rifamycin that inhibits DNA-dependent RNA synthesis. It is often used in the treatment of tuberculosis and leprosy. PMID:15700959 MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC. macB corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PDB:3FTJ macB pvdT antibiotic_resistance ARO:3000535 macB MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC. macB corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PMID:12832048 PMID:16359323 PMID:19432486 macB Novobiocin is produced from biosynthetic clusters in Streptomyces spheroides and Streptomyces niveus. antibiotic_resistance ARO:3000536 Streptomyces spheroides novobiocin biosynthetic gene cluster Novobiocin is produced from biosynthetic clusters in Streptomyces spheroides and Streptomyces niveus. PMID:10770754 PMID:10801869 MacAB-TolC is an ABC efflux pump complex expressed in E. coli and Salmonella enterica. It confers resistance to macrolides, including erythromycin. antibiotic_resistance ARO:3000545 MacAB-TolC MacAB-TolC is an ABC efflux pump complex expressed in E. coli and Salmonella enterica. It confers resistance to macrolides, including erythromycin. PMID:16359323 Clorobiocin is produced by a biosynthetic cluster in Streptomyces roseochromogenus subsp. oscitans. antibiotic_resistance ARO:3000546 Streptomyces roseochromogenus subsp. oscitans clorobiocin biosynthetic gene cluster Clorobiocin is produced by a biosynthetic cluster in Streptomyces roseochromogenus subsp. oscitans. PMID:12480894 PMID:16868863 ArlRS is a two-component regulatory system for NorA. ArlS phosphorylates ArlR to promote NorA expression. antibiotic_resistance ARO:3000547 arlRS ArlRS is a two-component regulatory system for NorA. ArlS phosphorylates ArlR to promote NorA expression. PMID:10633099 Coumermycin A1 is produced by a biosynthetic cluster in Streptomyces rishiriensis. antibiotic_resistance ARO:3000548 Streptomyces rishiriensis strain DSM 40489 coumermycin A1 biosynthetic gene cluster Coumermycin A1 is produced by a biosynthetic cluster in Streptomyces rishiriensis. PMID:11036020 PMID:16868863 AdeS is a sensor kinase in the AdeRS regulatory system of AdeABC. It is essential for AdeABC expression. adeS antibiotic_resistance ARO:3000549 adeS AdeS is a sensor kinase in the AdeRS regulatory system of AdeABC. It is essential for AdeABC expression. PMID:22371895 adeS Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death. pubchem.compound:5742832 ATM Primbactam antibiotic_resistance ARO:3000550 aztreonam Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death. PMID:3871589 Organoarsenic antibiotics are arsenic-containing compounds with antibacterial effects. The organoarsenic antibiotic arsphenamine and its derivatives were developed in the 1910s as the first modern chemotherapeutic agents. Salvarsan arsenical antibiotic_resistance ARO:3000551 organoarsenic antibiotic Arsphenamine, also known as Salvarsan and 606, is a drug that was used beginning in the 1910s to treat syphilis and trypanosomiasis. It is an organoarsenic compound and was the first modern chemotherapeutic agent. pubchem.compound:8774 Salvarsan antibiotic_resistance ARO:3000552 arsphenamine Arsphenamine, also known as Salvarsan and 606, is a drug that was used beginning in the 1910s to treat syphilis and trypanosomiasis. It is an organoarsenic compound and was the first modern chemotherapeutic agent. PMID:18679046 AdeR is a positive regulator of AdeABC efflux system. AdeR inactivation leads to susceptibility to aminoglycoside antibiotics. adeR antibiotic_resistance ARO:3000553 adeR AdeR is a positive regulator of AdeABC efflux system. AdeR inactivation leads to susceptibility to aminoglycoside antibiotics. PMID:22371895 adeR Mupirocin, also known as pseudomonic acid, is a bacteriostatic polyketide antibiotic from Pseudomonas fluorescens used to treat S. aureus and MRSA. It inhibits Ile tRNA synthetase. pubchem.compound:446596 pseudomonic acid antibiotic_resistance ARO:3000554 mupirocin Mupirocin, also known as pseudomonic acid, is a bacteriostatic polyketide antibiotic from Pseudomonas fluorescens used to treat S. aureus and MRSA. It inhibits Ile tRNA synthetase. PMID:21336932 Biosynthesis of macrolide antibiotics. antibiotic_resistance ARO:3000555 macrolide biosynthesis Tet44 is a tetracycline resistance gene found in Campylobacter fetus, and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein. tet(44) antibiotic_resistance ARO:3000556 tet(44) Tet44 is a tetracycline resistance gene found in Campylobacter fetus, and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein. PMID:20479200 tet(44) Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. antibiotic_resistance ARO:3000557 antibiotic inactivation enzyme AdeN is a repressor of AdeIJK, a RND-type efflux pump in Acinetobacter baumannii. Its inactivation increases expression of AdeJ. adeN antibiotic_resistance ARO:3000559 adeN AdeN is a repressor of AdeIJK, a RND-type efflux pump in Acinetobacter baumannii. Its inactivation increases expression of AdeJ. PMID:22371895 adeN Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype. antibiotic_resistance ARO:3000560 Erm 23S ribosomal RNA methyltransferase Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype. PMID:10582867 PMID:20618865 Tet30 is a tetracycline efflux pump found in agrobacterium, a Gram-negative bacterium. tet(30) tet30 antibiotic_resistance ARO:3000561 tet(30) Tet30 is a tetracycline efflux pump found in agrobacterium, a Gram-negative bacterium. PMID:11381101 PMID:9882678 tet(30) Tet38 is a tetracycline efflux pump found in the Gram-positive Staphylococcus aureus. It is regulated by mgrA, which also regulates NorB. tet(38) tet38 antibiotic_resistance ARO:3000565 tet(38) Tet38 is a tetracycline efflux pump found in the Gram-positive Staphylococcus aureus. It is regulated by mgrA, which also regulates NorB. PMID:15774883 tet(38) Tet39 is a tetracycline efflux pump found in Gram-negative bacteria, including Brevundimonas, Stenotrophomonas, Enterobacter, Alcaligenes, Acinetobacter, and Providencia. tet(39) tet39 tetA(39) antibiotic_resistance ARO:3000566 tet(39) Tet39 is a tetracycline efflux pump found in Gram-negative bacteria, including Brevundimonas, Stenotrophomonas, Enterobacter, Alcaligenes, Acinetobacter, and Providencia. PMID:15761075 tet(39) Tet40 is a tetracycline efflux pump found in the Gram-positive Clostridium. It is similar to tetA(P). tet(40) tet40 antibiotic_resistance ARO:3000567 tet(40) Tet40 is a tetracycline efflux pump found in the Gram-positive Clostridium. It is similar to tetA(P). PMID:18779355 tet(40) Subclass B1 possess a binuclear active site. Within this active site can be either one or two Zn(II) ions. This subclass is able to hydrolyze penicillins, cephalosporins and carbapenems. This is the most clinically relevant subclass of MBLs. antibiotic_resistance ARO:3000568 subclass B1 (metallo-) beta-lactamase Subclass B1 possess a binuclear active site. Within this active site can be either one or two Zn(II) ions. This subclass is able to hydrolyze penicillins, cephalosporins and carbapenems. This is the most clinically relevant subclass of MBLs. PMID:18563261 Tet41 is a tetracycline efflux pump found in Serratia, a Gram-negative bacterium. It is related to Acinetobacter Tet(39). tet(41) tet41 tetA(41) antibiotic_resistance ARO:3000569 tet(41) Tet41 is a tetracycline efflux pump found in Serratia, a Gram-negative bacterium. It is related to Acinetobacter Tet(39). PMID:17308196 tet(41) Metallo-beta-lactmases of subclass B2 contain only one Zn ion in their active site and selectively hydrolyze carbapenems. antibiotic_resistance ARO:3000570 subclass B2 (metallo-) beta-lactamase Metallo-beta-lactamases of subclass B3 are similar to B1 in that they have activity against penicillins, cephalosporins and carbapenems; however, the are only active with two Zn(II) ions in the active site. antibiotic_resistance ARO:3000571 subclass B3 (metallo-) beta-lactamase Metallo-beta-lactamases of subclass B3 are similar to B1 in that they have activity against penicillins, cephalosporins and carbapenems; however, the are only active with two Zn(II) ions in the active site. PMID:18563261 Tet42 is a tetracycline efflux pump found in both Gram-negative (Pseudomonas) and Gram-positive (Microbacterium, Bacillus, Staphylococcus, Paenibacillus) bacteria. tet(42) tet42 tetA(42) antibiotic_resistance ARO:3000572 tet(42) Tet42 is a tetracycline efflux pump found in both Gram-negative (Pseudomonas) and Gram-positive (Microbacterium, Bacillus, Staphylococcus, Paenibacillus) bacteria. PMID:18809935 tet(42) Tet(43) is a tetracycline resistance gene with unknown origins, isolated from metagenomic DNA. tet(43) tet43 antibiotic_resistance ARO:3000573 tet(43) Tet(43) is a tetracycline resistance gene with unknown origins, isolated from metagenomic DNA. PMID:11381101 tet(43) VanR is a OmpR-family transcriptional activator in the VanSR regulatory system. When activated by VanS, it promotes cotranscription of VanA, VanH, and VanX. antibiotic_resistance ARO:3000574 vanR VanR is a OmpR-family transcriptional activator in the VanSR regulatory system. When activated by VanS, it promotes cotranscription of VanA, VanH, and VanX. PMID:1556077 VanU is a transcriptional activator of vancomycin resistance genes. antibiotic_resistance ARO:3000575 vanU VanU is a transcriptional activator of vancomycin resistance genes. PMID:11036060 PMID:14617152 Enzymes that inactivate rifampin antibiotics by chemical modification. antibiotic_resistance ARO:3000576 rifampin inactivation enzyme Subclass B1 Bacillus cereus Bc beta-lactamases are zinc metallo-beta-lactamases that hydrolyze a large number of penicillins and cephalosporins. antibiotic_resistance ARO:3000577 subclass B1 Bacillus cereus Bc beta-lactamase Subclass B1 Bacillus cereus Bc beta-lactamases are zinc metallo-beta-lactamases that hydrolyze a large number of penicillins and cephalosporins. PMID:7588620 CcrA is a CfiA beta-lactamase. CciA CcrA antibiotic_resistance ARO:3000578 CcrA CcrA is a CfiA beta-lactamase. PMID:1510410 CcrA This BlaB specific to Chryseobacterium meningosepticum mediates resistance against many beta-lactam antibiotics, notably penams and carbapenems. Cmen_BlaB antibiotic_resistance ARO:3000579 Chryseobacterium meningosepticum BlaB This BlaB specific to Chryseobacterium meningosepticum mediates resistance against many beta-lactam antibiotics, notably penams and carbapenems. PMID:12019109 Cmen_BlaB Sao Paulo metallo-beta-lactamase (SPM-1) confers resistance to carbapenem in Pseudomonas aeruginosa. antibiotic_resistance ARO:3000580 SPM beta-lactamase Sao Paulo metallo-beta-lactamase (SPM-1) confers resistance to carbapenem in Pseudomonas aeruginosa. PMID:12407123 PMID:12951331 PMID:16239284 CphA is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophilia. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. antibiotic_resistance ARO:3000581 CphA beta-lactamase CphA is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophilia. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. PMID:18563261 L1 is an Ambler class B MBL; subclass B3 originally isolated from Stenotrophomonas maltophilia. It has activity against a broad range of beta-lactams and is only active with two Zn(II) ions in the active site. PDB:2QDT L1_BLA antibiotic_resistance ARO:3000582 L1 beta-lactamase L1 is an Ambler class B MBL; subclass B3 originally isolated from Stenotrophomonas maltophilia. It has activity against a broad range of beta-lactams and is only active with two Zn(II) ions in the active site. PMID:18563261 L1_BLA Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. pubchem.compound:11136668 Virginiamycin B antibiotic_resistance ARO:3000583 pristinamycin IA Quinupristin is a type B streptogramin and a semisynthetic derivative of pristinamycin 1A. It is a component of the drug Synercid and interacts with the 50S subunit of the bacterial ribosome to inhibit protein synthesis. pubchem.compound:5388937 antibiotic_resistance ARO:3000584 quinupristin Quinupristin is a type B streptogramin and a semisynthetic derivative of pristinamycin 1A. It is a component of the drug Synercid and interacts with the 50S subunit of the bacterial ribosome to inhibit protein synthesis. PMID:15700955 PMID:9746015 Pulvomycin is a polyketide antibiotic that binds elongation factor Tu (EF-Tu) to inhibit protein biosynthesis by preventing the formation of the ternary complex (EF-Tu*GTP*aa-tRNA). Phenotypically, it was shown that pulvomycin sensitivity is dominant over resistance. pubchem.compound:5282056 Labilomycin antibiotic_resistance ARO:3000586 pulvomycin Pulvomycin is a polyketide antibiotic that binds elongation factor Tu (EF-Tu) to inhibit protein biosynthesis by preventing the formation of the ternary complex (EF-Tu*GTP*aa-tRNA). Phenotypically, it was shown that pulvomycin sensitivity is dominant over resistance. PMID:15581367 PMID:16734421 PMID:364475 PMID:7957075 Sulbactam is an inhibitor of non-AmpC serine beta-lactamases. pubchem.compound:130313 antibiotic_resistance ARO:3000587 sulbactam Serine beta-lactamase inhibitor targeting class A, class C, and some class D enzymes. pubchem.compound:24944097 NXL-104 antibiotic_resistance ARO:3000588 avibactam Serine beta-lactamase inhibitor targeting class A, class C, and some class D enzymes. PMID:20921316 PMID:27480848 PMID:27528799 NDM-1 is a metallo-beta-lactamase isolated from Klebsiella pneumoniae with nearly complete resistance to all beta-lactam antibiotics. PDB:5ZGE NDM-1 antibiotic_resistance ARO:3000589 NDM-1 NDM-1 is a metallo-beta-lactamase isolated from Klebsiella pneumoniae with nearly complete resistance to all beta-lactam antibiotics. PMID:19770275 PMID:21507902 PMID:21774017 PMID:24790993 PMID:27575913 PMID:29454953 NDM-1 NDM-2 was isolated from a strain of Acinetobacter baumannii in Germany from a patient hospitalized in Cairo. A single amino acid substitution (P28R) differentiates this gene from NDM-1 and the two enzymes appear to have an identical spectrum of hydrolysis. NDM-2 antibiotic_resistance ARO:3000590 NDM-2 NDM-2 was isolated from a strain of Acinetobacter baumannii in Germany from a patient hospitalized in Cairo. A single amino acid substitution (P28R) differentiates this gene from NDM-1 and the two enzymes appear to have an identical spectrum of hydrolysis. PMID:21427107 NDM-2 ErmN is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is found in the tylosin biosynthetic cluster and is responsible for self-resistance to tylosin. ErmN tlrD antibiotic_resistance ARO:3000592 ErmN ErmN is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is found in the tylosin biosynthetic cluster and is responsible for self-resistance to tylosin. PMID:12019067 PMID:12417742 PMID:8973363 ErmN ErmQ confers MLSb phenotype. ErmQ antibiotic_resistance ARO:3000593 ErmQ ErmQ confers MLSb phenotype. PMID:8067735 ErmQ ErmR is a methyltransferase found in the erythromycin producer Aeromicrobium erythreum. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the erythromycin biosynthetic cluster and is responsible for self-resistance. ErmR antibiotic_resistance ARO:3000594 ErmR ErmR is a methyltransferase found in the erythromycin producer Aeromicrobium erythreum. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the erythromycin biosynthetic cluster and is responsible for self-resistance. PMID:1768148 ErmR ErmT confers MLSb phenotype. ErmT ermGT antibiotic_resistance ARO:3000595 ErmT ErmT confers MLSb phenotype. PMID:8171126 ErmT ErmX is a rRNA methyltransferase that protects the ribosome from inactivation due to antibiotic binding. ErmX ermCD ermCX antibiotic_resistance ARO:3000596 ErmX ErmX is a rRNA methyltransferase that protects the ribosome from inactivation due to antibiotic binding. PMID:11408212 ErmX Erm(31) confers a MLSb resistant phenotype. Along with erm(30), these genes are responsible for self-resistance in the pikromycin/narbomycin/methymycin/neomethymycin producer, Streptomyces venezuelae. Erm(31) Erm31 antibiotic_resistance ARO:3000598 Erm(31) Erm(31) confers a MLSb resistant phenotype. Along with erm(30), these genes are responsible for self-resistance in the pikromycin/narbomycin/methymycin/neomethymycin producer, Streptomyces venezuelae. PMID:14674753 PMID:9770448 Erm(31) ErmD confers MLSb phenotype. Erm(33) Erm33 antibiotic_resistance ARO:3000599 Erm(33) ErmD confers MLSb phenotype. PMID:12384375 Erm(33) ErmD confers MLSb phenotype. Erm(34) Erm34 antibiotic_resistance ARO:3000600 Erm(34) ErmD confers MLSb phenotype. PMID:14711653 Erm(34) ErmD confers MLSb phenotype. Erm(38) Erm38 antibiotic_resistance ARO:3000601 Erm(38) ErmD confers MLSb phenotype. PMID:16127056 Erm(38) ErmD confers MLSb phenotype. Erm(39) Erm39 antibiotic_resistance ARO:3000602 Erm(39) ErmD confers MLSb phenotype. PMID:15590712 Erm(39) Erm41 confers MLSb phenotype. Erm(41) Erm41 antibiotic_resistance ARO:3000603 Erm(41) Erm41 confers MLSb phenotype. PMID:27244062 Erm(41) ErmD confers MLSb phenotype. Erm(35) Erm35 antibiotic_resistance ARO:3000604 Erm(35) ErmD confers MLSb phenotype. PMID:1804017 Erm(35) ErmD confers MLSb phenotype. Erm(36) Erm36 antibiotic_resistance ARO:3000605 Erm(36) ErmD confers MLSb phenotype. PMID:12177341 Erm(36) FEZ-1 is an Ambler class B MBL; subclass B3 first isolated from Legionella gormanii. It has activity against a broad range of beta-lactams and is only active with two Zn(II) ions in the active site. FEZ-1 antibiotic_resistance ARO:3000606 FEZ-1 FEZ-1 is an Ambler class B MBL; subclass B3 first isolated from Legionella gormanii. It has activity against a broad range of beta-lactams and is only active with two Zn(II) ions in the active site. PMID:12507470 PMID:18563261 FEZ-1 Many genes involved in antibiotic resistance are mobile and microarray probes for these genes can thus provide positive results for any number of organisms. CARD stores the coding sequences of genes targeted by the probe sets of available antibiotic resistance microarrays. antibiotic_resistance ARO:3000610 gene detected by antibiotic resistance screening microarray Many genes involved in antibiotic resistance are mobile and microarray probes for these genes can thus provide positive results for any number of organisms. CARD stores the coding sequences of genes targeted by the probe sets of available antibiotic resistance microarrays. PMID:20035807 PMID:20356716 mef(E) is a proton motive efflux pump in Streptococcus pneumoniae that confers resistance to macrolides. It is found on the same operon as mefA and the ABC-efflux pump mel. mef(E) mefE antibiotic_resistance ARO:3000614 mef(E) mef(E) is a proton motive efflux pump in Streptococcus pneumoniae that confers resistance to macrolides. It is found on the same operon as mefA and the ABC-efflux pump mel. PMID:16189099 mef(E) Mel, a homolog of MsrA, is an ABC-F subfamily protein associated with macrolide resistance. It is expressed on the same operon as mefA and mefE, both MFS-type efflux proteins that confer macrolide resistance. mefA mel msr(D) msrD antibiotic_resistance ARO:3000616 mel Mel, a homolog of MsrA, is an ABC-F subfamily protein associated with macrolide resistance. It is expressed on the same operon as mefA and mefE, both MFS-type efflux proteins that confer macrolide resistance. PMID:16189099 PMID:22137270 PMID:23114767 mel A foreign PBP2a acquired by lateral gene transfer that is able to perform peptidoglycan synthesis in the presence of beta-lactams. PBP2A mecA antibiotic_resistance ARO:3000617 mecA A foreign PBP2a acquired by lateral gene transfer that is able to perform peptidoglycan synthesis in the presence of beta-lactams. PMID:12389036 PMID:15226303 PMID:18718557 PMID:21636525 PMID:21931689 PMID:2708325 PMID:27547406 PMID:3878127 PMID:6563036 mecA ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParC prevent fluoroquinolone antibiotics from inhibiting DNA synthesis, and confer low-level resistance. Higher-level resistance results from both gyrA and parC mutations. antibiotic_resistance ARO:3000619 fluoroquinolone resistant parC ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParC prevent fluoroquinolone antibiotics from inhibiting DNA synthesis, and confer low-level resistance. Higher-level resistance results from both gyrA and parC mutations. PMID:18471102 PMID:8913454 PMID:9293187 AdeL is a regulator of AdeFGH in Acinetobacter baumannii. AdeL mutations are associated with AdeFGH overexpression and multidrug resistance. adeL antibiotic_resistance ARO:3000620 adeL AdeL is a regulator of AdeFGH in Acinetobacter baumannii. AdeL mutations are associated with AdeFGH overexpression and multidrug resistance. PMID:20696879 adeL The blaZ beta-lactamase is found in Bacillus subtilis and Staphylococcus aureus. PDB:3BLM PC1_blaZ antibiotic_resistance ARO:3000621 PC1 beta-lactamase (blaZ) The blaZ beta-lactamase is found in Bacillus subtilis and Staphylococcus aureus. PMID:17986343 PMID:6793593 PC1_blaZ Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. pubchem.compound:202195 polymyxin E1 antibiotic_resistance ARO:3000622 colistin A Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. PMID:19157746 PMID:20818945 Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. pubchem.compound:25138298 polymyxin E2 antibiotic_resistance ARO:3000624 colistin B Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. PMID:19157746 PMID:20818945 Polymyxin B1 is in the family of polymyxin lipopeptides with a 6-methyloctanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. pubchem.compound:199402 antibiotic_resistance ARO:3000625 polymyxin B1 Polymyxin B1 is in the family of polymyxin lipopeptides with a 6-methyloctanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. PMID:11330807 Polymyxin B2 is in the family of polymyxin lipopeptides with a 6-methylheptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. pubchem.compound:11982455 antibiotic_resistance ARO:3000626 polymyxin B2 Polymyxin B2 is in the family of polymyxin lipopeptides with a 6-methylheptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. PMID:11330807 Polymyxin B3 is in the family of polymyxin lipopeptides with an octanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. pubchem.compound:46883542 antibiotic_resistance ARO:3000627 polymyxin B3 Polymyxin B3 is in the family of polymyxin lipopeptides with an octanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. PMID:11330807 Polymyxin B4 is in the family of polymyxin lipopeptides with a heptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. pubchem.compound:46883543 antibiotic_resistance ARO:3000628 polymyxin B4 Polymyxin B4 is in the family of polymyxin lipopeptides with a heptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. PMID:11330807 Bacitracin A is the primary component of bacitracin. It contains many uncommon amino acids and interferes with bacterial cell wall synthesis. pubchem.compound:10909430 antibiotic_resistance ARO:3000629 bacitracin A Bacitracin A is the primary component of bacitracin. It contains many uncommon amino acids and interferes with bacterial cell wall synthesis. PMID:6752975 Bacitracin B is a component of bacitracin, an antibiotic mixture that interferes with bacterial cell wall synthesis. It differs from Bacitracin A with a valine instead of an isoleucine in its peptide. pubchem.compound:121232829 antibiotic_resistance ARO:3000630 bacitracin B Bacitracin B is a component of bacitracin, an antibiotic mixture that interferes with bacterial cell wall synthesis. It differs from Bacitracin A with a valine instead of an isoleucine in its peptide. PMID:6752975 Bacitracin F is a component of bacitracin, an antibiotic mixture that interferes with bacterial cell wall synthesis. It is formed when the thiazoline ring of bacitracin A is oxidatively deaminated. pubchem.compound:3082210 antibiotic_resistance ARO:3000631 bacitracin F Bacitracin F is a component of bacitracin, an antibiotic mixture that interferes with bacterial cell wall synthesis. It is formed when the thiazoline ring of bacitracin A is oxidatively deaminated. PMID:6752975 Benzylpenicillin, commonly referred to as penicillin G, is effective against both Gram-positive and Gram-negative bacteria. It is unstable in acid. pubchem.compound:5904 Penicillin G benzopenicillin antibiotic_resistance ARO:3000632 benzylpenicillin Benzylpenicillin, commonly referred to as penicillin G, is effective against both Gram-positive and Gram-negative bacteria. It is unstable in acid. PMID:4610013 Phenoxymethylpenicillin, or penicillin V, is a penicillin derivative that is acid stable but less active than benzylpenicillin (penicillin G). pubchem.compound:6869 penicillin V phenomycilline phenopenicillin antibiotic_resistance ARO:3000633 phenoxymethylpenicillin Phenoxymethylpenicillin, or penicillin V, is a penicillin derivative that is acid stable but less active than benzylpenicillin (penicillin G). PMID:3924086 Propicillin is an orally taken penicillin derivative that has high absorption but poor activity. pubchem.compound:92879 levopropicillin antibiotic_resistance ARO:3000634 propicillin Propicillin is an orally taken penicillin derivative that has high absorption but poor activity. PMID:14056922 PMID:3588519 Dicloxacillin is a penicillin derivative that has an extra chlorine atom in comparison to cloxacillin. While more active than cloxacillin, its high affinity for serum protein reduces its activity in human serum in vitro. pubchem.compound:18381 dicloxacilin dicloxacycline antibiotic_resistance ARO:3000635 dicloxacillin Dicloxacillin is a penicillin derivative that has an extra chlorine atom in comparison to cloxacillin. While more active than cloxacillin, its high affinity for serum protein reduces its activity in human serum in vitro. PMID:3588519 PMID:3764352 Flucloxacillin is similar to cloxacillin, with an extra additional fluorine atom. pubchem.compound:21319 floxacillin floxapen antibiotic_resistance ARO:3000636 flucloxacillin Flucloxacillin is similar to cloxacillin, with an extra additional fluorine atom. PMID:3588519 Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. pubchem.compound:6249 AMP Principen ampicillin acid antibiotic_resistance ARO:3000637 ampicillin Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. PMID:3224398 PMID:44765 Azlocillin is a semisynthetic derivative of penicillin that is notably active against Ps. aeruginosa and other Gram-negative bacteria. pubchem.compound:6479523 AZL antibiotic_resistance ARO:3000638 azlocillin Azlocillin is a semisynthetic derivative of penicillin that is notably active against Ps. aeruginosa and other Gram-negative bacteria. PMID:6369480 Mezlocillin is a penicillin derivative taken parenterally. pubchem.compound:656511 mezlin antibiotic_resistance ARO:3000639 mezlocillin Mezlocillin is a penicillin derivative taken parenterally. PMID:6369480 Doripenem is a carbapenem with a broad range of activity against Gram-positive and Gram-negative bacteria, and along with meropenem, it is the most active beta-lactam antibiotic against Pseudomonas aeruginosa. It inhibits bacterial cell wall synthesis. pubchem.compound:73303 doribax antibiotic_resistance ARO:3000640 doripenem Doripenem is a carbapenem with a broad range of activity against Gram-positive and Gram-negative bacteria, and along with meropenem, it is the most active beta-lactam antibiotic against Pseudomonas aeruginosa. It inhibits bacterial cell wall synthesis. PMID:15047550 PMID:16307551 Cefalexin is a cephalosporin antibiotic that causes filamentation. It is resistant to staphylococcal beta-lactamase, but degraded by enterobacterial beta-lactamases. pubchem.compound:27447 LEX cephalexin antibiotic_resistance ARO:3000641 cefalexin Cefalexin is a cephalosporin antibiotic that causes filamentation. It is resistant to staphylococcal beta-lactamase, but degraded by enterobacterial beta-lactamases. PMID:4559812 Cefadroxil, or p-hydroxycephalexin, is an cephalosporin antibiotic similar to cefalexin. pubchem.compound:47965 CFR p-hydroxycephalexin antibiotic_resistance ARO:3000642 cefadroxil Cefadroxil, or p-hydroxycephalexin, is an cephalosporin antibiotic similar to cefalexin. PMID:3542485 Cefotiam is a cephalosporin antibiotic with similar activity to cefuroxime but more active against enterobacteria. It is consumed orally as the prodrug cefotiam hexetil. pubchem.compound:43708 cefotiamum antibiotic_resistance ARO:3000643 cefotiam Cefotiam is a cephalosporin antibiotic with similar activity to cefuroxime but more active against enterobacteria. It is consumed orally as the prodrug cefotiam hexetil. PMID:18611654 Cefaclor is a semisynthetic cephalosporin derived from cephalexin. It has broad-spectrum antibiotic activity. pubchem.compound:51039 CEC ceclor cephaclor antibiotic_resistance ARO:3000644 cefaclor Cefaclor is a semisynthetic cephalosporin derived from cephalexin. It has broad-spectrum antibiotic activity. PMID:10435677 Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups. pubchem.compound:5742673 CTX cefotaxime acid antibiotic_resistance ARO:3000645 cefotaxime Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups. PMID:2083516 Cefixime is a cephalosporin resistant to most beta-lactamases. It is active against many enterobacteria, but activity against staphylococci is poor. pubchem.compound:5362065 CFM necopen antibiotic_resistance ARO:3000646 cefixime Cefixime is a cephalosporin resistant to most beta-lactamases. It is active against many enterobacteria, but activity against staphylococci is poor. PMID:2684593 Cefpodoxime is a semisynthetic cephalosporin that acts similarly to cefotaxime with broad-spectrum activity. It is stable to many plasmid-mediated beta-lactamses. Cefpodoxime is consumed as the prodrug cefpodoxime proxetil. pubchem.compound:6335986 CPD antibiotic_resistance ARO:3000647 cefpodoxime Cefpodoxime is a semisynthetic cephalosporin that acts similarly to cefotaxime with broad-spectrum activity. It is stable to many plasmid-mediated beta-lactamses. Cefpodoxime is consumed as the prodrug cefpodoxime proxetil. PMID:1280571 PMID:18611588 Ceftibuten is a semisynthetic cephalosporin active against Gram-negative bacilli. It is resistant against many plasmid-mediated beta-lactamases. pubchem.compound:5282242 CTB Cedax antibiotic_resistance ARO:3000648 ceftibuten Ceftibuten is a semisynthetic cephalosporin active against Gram-negative bacilli. It is resistant against many plasmid-mediated beta-lactamases. PMID:7520858 PMID:9296244 Cefditoren is a semisynthetic cephalosporin active against staphylococci, streptococci, and and most enterobacteria. It is resistant to staphylococcal and most enterobacterial beta-lactamases, and is usually taken as the prodrug cefditoren pivoxil. pubchem.compound:9571074 CDN antibiotic_resistance ARO:3000649 cefditoren Cefditoren is a semisynthetic cephalosporin active against staphylococci, streptococci, and and most enterobacteria. It is resistant to staphylococcal and most enterobacterial beta-lactamases, and is usually taken as the prodrug cefditoren pivoxil. PMID:7813385 Cefdinir is similar to cefixime with a modified side-chain at its 7-amino position. It also shares similar activity with cefixime but is more active against staphylococci. It has also be shown to enhance phagocytosis. pubchem.compound:6915944 CDR antibiotic_resistance ARO:3000650 cefdinir Cefdinir is similar to cefixime with a modified side-chain at its 7-amino position. It also shares similar activity with cefixime but is more active against staphylococci. It has also be shown to enhance phagocytosis. PMID:8026155 Ceftaroline is a novel cephalosporin active against methicillin resistant Staphylococcus aureus. Like other cephalosporins it binds penicillin-binding proteins to inhibit cell wall synthesis. It strongly binds with PBP2a, associated with methicillin resistance. It is taken orally as the prodrug ceftaroline fosamil. pubchem.compound:9852982 CPT T91825 ceftaroline fosamil antibiotic_resistance ARO:3000651 ceftaroline Ceftaroline is a novel cephalosporin active against methicillin resistant Staphylococcus aureus. Like other cephalosporins it binds penicillin-binding proteins to inhibit cell wall synthesis. It strongly binds with PBP2a, associated with methicillin resistance. It is taken orally as the prodrug ceftaroline fosamil. PMID:18827379 PMID:21467022 PMID:27721280 A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae. pubchem.compound:3037209 isepamicine isepamicinum antibiotic_resistance ARO:3000652 isepamicin A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae. PMID:8622111 A gentamicin class aminoglycoside antibiotic often used in mammalian cell culture work as a selectable marker for the neo cassette (APH3'). pubchem.compound:123865 geneticin antibiotic_resistance ARO:3000653 G418 A gentamicin class aminoglycoside antibiotic often used in mammalian cell culture work as a selectable marker for the neo cassette (APH3'). PMID:4007271 PMID:6378088 A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci. pubchem.compound:68682 habekacin haberacin antibiotic_resistance ARO:3000654 arbekacin A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci. PMID:10858356 PMID:7559197 Gentamicin B is a semisynthetic aminoglycoside antibacterial. pubchem.compound:11754987 betamicin antibiotic_resistance ARO:3000655 gentamicin B Gentamicin B is a semisynthetic aminoglycoside antibacterial. PMID:9872733 AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. AcrS ECK3251 JW3232 envR yhdK antibiotic_resistance ARO:3000656 AcrS AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. PMID:18567659 AcrS An aminoglycoside antibiotic used for the treatment of parasitic infections. It is similar to neomycin sharing a similar spectrum of activity, but its hydroxyl group at the 6'-position instead of an amino group makes it resistant to AAC(6') modifying enzymes. pubchem.compound:165580 Gabbomycin Humagel Humatin aminosidin aminosidine catenulin crestomycin estomycin hydroxymycin monomycin A neomycin E paucimycin antibiotic_resistance ARO:3000657 paromomycin An aminoglycoside antibiotic used for the treatment of parasitic infections. It is similar to neomycin sharing a similar spectrum of activity, but its hydroxyl group at the 6'-position instead of an amino group makes it resistant to AAC(6') modifying enzymes. PMID:11083628 PMID:8182014 Lividomycins are aminoglycosidic antibiotics produced by Streptomyces lividus. They contain 2-amino-2,3-dideoxy-D-glucose. pubchem.compound:72394 antibiotic_resistance ARO:3000658 lividomycin Lividomycins are aminoglycosidic antibiotics produced by Streptomyces lividus. They contain 2-amino-2,3-dideoxy-D-glucose. PMID:4586150 PMID:5091208 Gatifloxacin is an 8-methoxy, 7-piperazinyl, 6-fluoroquinolone that can be taken orally or by intravenous administration. It is active against most Gram-positive and Gram-negative bacteria, but inactive against non-fermenting Gram-negative rods including Pseudomonas aeruginosa. pubchem.compound:5379 AM-1155 Tequin antibiotic_resistance ARO:3000659 gatifloxacin Gatifloxacin is an 8-methoxy, 7-piperazinyl, 6-fluoroquinolone that can be taken orally or by intravenous administration. It is active against most Gram-positive and Gram-negative bacteria, but inactive against non-fermenting Gram-negative rods including Pseudomonas aeruginosa. PMID:8522459 Lomefloxacin is a difluoropiperazinyl quinolone, sharing similar activities with other fluoroquinolones. It is used to treat urinary tract infections. Relative to other fluoroquinolones, it has a longer half life and has higher serum concentrations. pubchem.compound:3948 antibiotic_resistance ARO:3000660 lomefloxacin Lomefloxacin is a difluoropiperazinyl quinolone, sharing similar activities with other fluoroquinolones. It is used to treat urinary tract infections. Relative to other fluoroquinolones, it has a longer half life and has higher serum concentrations. PMID:8394795 Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments. pubchem.compound:4421 nalidixin antibiotic_resistance ARO:3000661 nalidixic acid Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments. PMID:18159374 Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes. pubchem.compound:4539 antibiotic_resistance ARO:3000662 norfloxacin Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes. PMID:3908074 Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant. pubchem.compound:4583 Tarivid floxin antibiotic_resistance ARO:3000663 ofloxacin Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant. PMID:1611900 PMID:18159374 PMID:3028966 Trovafloxacin is a trifluoroquinalone with a broad spectrum of activity that acts by inhibiting the uncoiling of supercoiled DNA. While potent against many Gram-positive and Gram-negative bacteria, it is less active against pseudomonads and Cl. difficile. It is usually taken as the prodrug trovafloxacin mesylate or alatrofloxacin mesylate for oral or intravenous administration, respectively. pubchem.compound:62959 Trovan alatrofloxacin antibiotic_resistance ARO:3000664 trovafloxacin Grepafloxacin is a broad-spectrum antibacterial quinoline. It is no longer taken due to its high toxicity. pubchem.compound:72474 Raxar antibiotic_resistance ARO:3000665 grepafloxacin Grepafloxacin is a broad-spectrum antibacterial quinoline. It is no longer taken due to its high toxicity. PMID:15992094 PMID:18159374 Sparfloxacin is a dimethylpiperazinyl difluoroquinolone that acts by inhibiting DNA gyrase. It is active against aerobic Gram-positive and Gram-negative bacteria, as well as some mycobacteria. It has moderate activity against some anaerobes. pubchem.compound:60464 Zagam antibiotic_resistance ARO:3000666 sparfloxacin Sparfloxacin is a dimethylpiperazinyl difluoroquinolone that acts by inhibiting DNA gyrase. It is active against aerobic Gram-positive and Gram-negative bacteria, as well as some mycobacteria. It has moderate activity against some anaerobes. PMID:1317145 Demeclocycline is a tetracycline analog with 7-chloro and 6-methyl groups. Due to its fast absorption and slow excretion, it maintains higher effective blood levels compared to other tetracyclines. pubchem.compound:54680690 DMCTC declomycin antibiotic_resistance ARO:3000667 demeclocycline Demeclocycline is a tetracycline analog with 7-chloro and 6-methyl groups. Due to its fast absorption and slow excretion, it maintains higher effective blood levels compared to other tetracyclines. PMID:194065 Oxytetracycline is a derivative of tetracycline with a 5-hydroxyl group. Its activity is similar to other tetracyclines. pubchem.compound:54675779 antibiotic_resistance ARO:3000668 oxytetracycline Oxytetracycline is a derivative of tetracycline with a 5-hydroxyl group. Its activity is similar to other tetracyclines. PMID:11381101 Virginiamycin M1 is a streptogramin A antibiotic. pubchem.compound:46936184 Pristinamycin IIA Pristinamycin IIB Virginiamycin IIB antibiotic_resistance ARO:3000669 virginiamycin M1 Virginiamycin M1 is a streptogramin A antibiotic. PMID:15700955 Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes. antibiotic_resistance ARO:3000670 pleuromutilin antibiotic Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes. PMID:11555289 PMID:15554968 PMID:16569865 PMID:17360517 PMID:20112168 PMID:931799 Tiamulin is a pleuromutilin derivative currently used in veterinary medicine. It binds to the 23 rRNA of the 50S ribosomal subunit to inhibit protein translation. pubchem.compound:656958 antibiotic_resistance ARO:3000671 tiamulin Tiamulin is a pleuromutilin derivative currently used in veterinary medicine. It binds to the 23 rRNA of the 50S ribosomal subunit to inhibit protein translation. PMID:11555289 PMID:15554968 PMID:19362093 PMID:20112168 Madumycin II is a streptogramin A antibiotic. pubchem.compound:6441077 A2315A madumicin II antibiotic_resistance ARO:3000672 madumycin II Madumycin II is a streptogramin A antibiotic. PMID:15700955 Griseoviridin is a streptogramin A antibiotic. pubchem.compound:6441064 antibiotic_resistance ARO:3000673 griseoviridin Griseoviridin is a streptogramin A antibiotic. PMID:15700955 Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria. pubchem.compound:6323289 antibiotic_resistance ARO:3000674 dalfopristin Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria. PMID:15700955 Pristinamycin IB is a class B streptogramin similar to pristinamycin IA, the former containing a N-methyl-4-(methylamino)phenylalanine instead of a N-methyl-4-(dimethylamino)phenylalanine in its class A streptogramin counterpart (one less methyl group). pubchem.compound:443309 Virginiamycin S1 antibiotic_resistance ARO:3000675 pristinamycin IB Pristinamycin IB is a class B streptogramin similar to pristinamycin IA, the former containing a N-methyl-4-(methylamino)phenylalanine instead of a N-methyl-4-(dimethylamino)phenylalanine in its class A streptogramin counterpart (one less methyl group). PMID:15700955 H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE, mdtE, and emrK as well as nearby genes of many RND-type multidrug exporters. H-NS hns antibiotic_resistance ARO:3000676 H-NS H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE, mdtE, and emrK as well as nearby genes of many RND-type multidrug exporters. PMID:14973023 H-NS Virginiamycin S2 is a streptogramin B antibiotic. pubchem.compound:101826968 antibiotic_resistance ARO:3000677 virginiamycin S2 Virginiamycin S2 is a streptogramin B antibiotic. PMID:15700955 Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. pubchem.compound:443310 Vernamycin B gamma Virginiamycin S1 antibiotic_resistance ARO:3000678 pristinamycin IC Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. PMID:15700955 Vernamycin C is a streptogramin B antibiotic. pubchem.compound:90478435 antibiotic_resistance ARO:3000679 vernamycin C Vernamycin C is a streptogramin B antibiotic. PMID:15700955 Patricin A is a streptogramin B antibiotic. pubchem.compound:13041217 antibiotic_resistance ARO:3000680 patricin A Patricin A is a streptogramin B antibiotic. PMID:15700955 Patricin B is a streptogramin B antibiotic. pubchem.compound:13041217 antibiotic_resistance ARO:3000681 patricin B Patricin B is a streptogramin B antibiotic. PMID:15700955 Ostreogrycin B3 is a derivative of pristinamycin IA, with an additional 3-hydroxy group on its 4-oxopipecolic acid. pubchem.compound:71751769 antibiotic_resistance ARO:3000682 ostreogrycin B3 Ostreogrycin B3 is a derivative of pristinamycin IA, with an additional 3-hydroxy group on its 4-oxopipecolic acid. PMID:15700955 Sulfacetamide is a very soluable sulfonamide antibiotic previously used to treat urinary tract infections. Its relatively low activity and toxicity to those with Stevens-Johnson syndrome have reduced its use and availability. pubchem.compound:5320 antibiotic_resistance ARO:3000683 sulfacetamide Sulfacetamide is a very soluable sulfonamide antibiotic previously used to treat urinary tract infections. Its relatively low activity and toxicity to those with Stevens-Johnson syndrome have reduced its use and availability. PMID:8133250 Mafenide is a sulfonamide used topically for treating burns. pubchem.compound:3998 ambamide maphenide sulfamylon antibiotic_resistance ARO:3000684 mafenide Mafenide is a sulfonamide used topically for treating burns. PMID:4948236 Arylomycins are lipopeptide antibiotics, sharing a lipohexapeptide with a C-terminal tripeptide macrolide and varying by the length of its alkyl chains. pubchem.compound:54586211 antibiotic_resistance ARO:3000685 arylomycin Arylomycins are lipopeptide antibiotics, sharing a lipohexapeptide with a C-terminal tripeptide macrolide and varying by the length of its alkyl chains. PMID:21545107 Thiostrepton is a cyclic peptide active against Gram-positive bacteria. It is produced by streptomyces bacteria. pubchem.compound:16129666 bryamycin thiactin antibiotic_resistance ARO:3000686 thiostrepton Thiostrepton is a cyclic peptide active against Gram-positive bacteria. It is produced by streptomyces bacteria. PMID:5409975 Moemomycin antibiotics are phosphoglycolipids that contain a 3-phosphoglyceric acid, often used as a mixture. They inhibit petidoglycan glycosyltransferases to prevent bacterial cell wall biosynthesis. Flavomycin Flavophospholipol bambermycin antibiotic_resistance ARO:3000687 moenomycin Moemomycin antibiotics are phosphoglycolipids that contain a 3-phosphoglyceric acid, often used as a mixture. They inhibit petidoglycan glycosyltransferases to prevent bacterial cell wall biosynthesis. PMID:17117848 PMID:20730219 Furazolidone is a nitrofuran antibiotic that is a non-ionic synthetic compound. It is taken orally and is active against many enteric pathogens. Furazolidone also has antiprotozoal activity and acts by inhibiting monoamine oxidase. pubchem.compound:5323714 furazolidine furoxone nitrofurazolidone antibiotic_resistance ARO:3000688 furazolidone Furazolidone is a nitrofuran antibiotic that is a non-ionic synthetic compound. It is taken orally and is active against many enteric pathogens. Furazolidone also has antiprotozoal activity and acts by inhibiting monoamine oxidase. PMID:3514312 Metronidazole is a nitroimidazole that is active against anaerobic bacteria and protozoa. It is not effective against aerobic bacteria. Nitroimidazoles act by oxidizing DNA causing strand breaks and cell death. pubchem.compound:4173 Flagyl metronidazol antibiotic_resistance ARO:3000689 metronidazole Metronidazole is a nitroimidazole that is active against anaerobic bacteria and protozoa. It is not effective against aerobic bacteria. Nitroimidazoles act by oxidizing DNA causing strand breaks and cell death. PMID:8444678 Bleomycinic acid is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids. pubchem.compound:2410 antibiotic_resistance ARO:3000690 bleomycinic acid Bleomycinic acid is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids. PMID:15700963 Bleomycin A2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids. pubchem.compound:5460769 antibiotic_resistance ARO:3000691 bleomycin A2 Bleomycin A2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids. PMID:15700963 Bleomycin B2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids. pubchem.compound:5496540 antibiotic_resistance ARO:3000692 bleomycin B2 Bleomycin B2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids. PMID:15700963 Defensins are natural cationic peptides that have antibiotic properties. It is part of the innate immune system of plants and animals. pubchem.compound:56841867 antibiotic_resistance ARO:3000693 defensin Defensins are natural cationic peptides that have antibiotic properties. It is part of the innate immune system of plants and animals. PMID:12949495 Magainins are antimicrobial peptides produced by amphibians skil cells as part of their innate immune system. It is active against a broad range of gram-negative and gram-positive bacteria, fungi and protozoa. megainin antibiotic_resistance ARO:3000694 magainin Magainins are antimicrobial peptides produced by amphibians skil cells as part of their innate immune system. It is active against a broad range of gram-negative and gram-positive bacteria, fungi and protozoa. PMID:3277183 Actinomycins are peptide antibiotics that interact with DNA. This prevents RNA synthesis, thus preventing the production of proteins vital to the cell. antibiotic_resistance ARO:3000695 actinomycin Actinomycins are peptide antibiotics that interact with DNA. This prevents RNA synthesis, thus preventing the production of proteins vital to the cell. PMID:2410919 Dactinomycin, also known as Actinomycin D, is a cyclic peptide antibiotic that interacts with DNA to inhibit RNA synthesis. pubchem.compound:457193 Actinomycin D antibiotic_resistance ARO:3000696 Dactinomycin Dactinomycin, also known as Actinomycin D, is a cyclic peptide antibiotic that interacts with DNA to inhibit RNA synthesis. PMID:2410919 Moenomycin A1 is a major component of moenomycin mixtures. It is produced by Streptomyces ghanaensis, S. bambergiensis, S. ederensis, and S. geysiriensis. pubchem.compound:15235578 antibiotic_resistance ARO:3000697 moenomycin A1 Moenomycin A1 is a major component of moenomycin mixtures. It is produced by Streptomyces ghanaensis, S. bambergiensis, S. ederensis, and S. geysiriensis. PMID:17117848 Sulfasalazine is a derivative of the early sulfonamide sulfapyridine (salicylazosulfapyridine). It was developed to increase water solubility and is taken orally for ulcerative colitis. pubchem.compound:5339 salicylazosulfapyridine antibiotic_resistance ARO:3000698 sulfasalazine Sulfasalazine is a derivative of the early sulfonamide sulfapyridine (salicylazosulfapyridine). It was developed to increase water solubility and is taken orally for ulcerative colitis. PMID:22555 Sulfamethizole is a short-acting sulfonamide that inhibits dihydropteroate synthetase. pubchem.compound:5328 Urolucosil sulfamethizol sulphamethizole antibiotic_resistance ARO:3000699 sulfamethizole Sulfamethizole is a short-acting sulfonamide that inhibits dihydropteroate synthetase. PMID:2372557 Lividomycin A is a pentasaccharide antibiotic which interferes with bacterial protein synthesis. pubchem.compound:72394 antibiotic_resistance ARO:3000700 lividomycin A Lividomycin A is a pentasaccharide antibiotic which interferes with bacterial protein synthesis. PMID:4586150 PMID:5092786 Lividomycin B is a derivative of lividomycin A with a removed mannose group (demannosyllividomycin A). Livodomycins interfere with bacterial protein synthesis. pubchem.compound:46174031 antibiotic_resistance ARO:3000701 lividomycin B Lividomycin B is a derivative of lividomycin A with a removed mannose group (demannosyllividomycin A). Livodomycins interfere with bacterial protein synthesis. PMID:4586150 PMID:5034809 AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. antibiotic_resistance ARO:3000702 acrR AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. PMID:12121946 Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. pubchem.compound:6024 CEF cephalothin antibiotic_resistance ARO:3000704 cefalotin Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. PMID:14251901 PMID:7571387 Isopenicillin N is a natural penicillin derivative produced by Penicillium chrysogenum with activity similar to penicillin N. pubchem.compound:440723 antibiotic_resistance ARO:3000705 isopenicillin N Isopenicillin N is a natural penicillin derivative produced by Penicillium chrysogenum with activity similar to penicillin N. PMID:4209314 Penicillin N is a penicillin derivative produced by Cephalosporium acremonium. pubchem.compound:71724 antibiotic_resistance ARO:3000706 penicillin N Penicillin N is a penicillin derivative produced by Cephalosporium acremonium. PMID:4209314 Mixtures of antibiotics are commonly used clinically. These mixtures link to antibiotic molecules that are also listed in their respective families under antibiotic molecules. i.e. 'Gramicidin A' is part of the mixture 'gramicidin D', while 'Gramicidin A' is also a 'gramicidin', which is a 'peptide antibiotic'. antibiotic_resistance ARO:3000707 antibiotic mixture Antibiotic targets are components of the bacterial or fungal cell. Bacterial targets are usually significantly different from their eukaryotic counterparts to allow for selective antibacterial activity. Exceptions include antibiotics that are converted to an active form inside the bacterium. Resistance mechanisms may modify these targets to protect bacteria or fungi from the effects of antibiotics. antibiotic_resistance ARO:3000708 antibiotic target Cell wall biosynthesis provides bacteria with a layer of peptidoglycan that provides rigidity and protects the cell from lysis due to osmotic pressure. Cell wall structures vary significantly between Gram-positive and Gram-negative bacteria, while mycobacteria have a unique cell wall composition. antibiotic_resistance ARO:3000709 cell wall synthesis enzyme targeted by antibiotic Cell wall biosynthesis provides bacteria with a layer of peptidoglycan that provides rigidity and protects the cell from lysis due to osmotic pressure. Cell wall structures vary significantly between Gram-positive and Gram-negative bacteria, while mycobacteria have a unique cell wall composition. PMID:1436736 Interaction with the cell membrane phospholipids interferes with membrane permeability and integrity, leading to the leakage of cell contents. The outer membrane of Gram-negative bacteria is particularly sensitive. antibiotic_resistance ARO:3000710 cell membrane component targeted by antibiotic Interaction with the cell membrane phospholipids interferes with membrane permeability and integrity, leading to the leakage of cell contents. The outer membrane of Gram-negative bacteria is particularly sensitive. PMID:17572379 PMID:20818945 PMID:4334683 PMID:8528769 Protein synthesis in bacteria is accomplished by cytosolic ribosomes that are structurally different from eukaryotic ribosomes, and thus a target for many antibiotics. By inhibiting ribosomal activity, either by directly binding to the ribosome or interacting with co-factors, antibiotics prevent protein synthesis. antibiotic_resistance ARO:3000711 protein synthesis machinery targeted by antibiotic Bacterial DNA and RNA synthesis includes many enzymes unique to bacteria that are targeted by antibiotics. antibiotic_resistance ARO:3000712 nucleic acid synthesis machinery targeted by antibiotic Bacterial DNA and RNA synthesis includes many enzymes unique to bacteria that are targeted by antibiotics. PMID:22458504 Nucleic acids can also be targeted by antibiotics. These drugs are usually converted to an active form by enzymes unique to bacteria to prevent toxicity to the host. antibiotic_resistance ARO:3000713 nucleic acid targeted by antibiotic Nucleic acids can also be targeted by antibiotics. These drugs are usually converted to an active form by enzymes unique to bacteria to prevent toxicity to the host. PMID:15685195 Enzymes in the folate synthesis pathway are targeted by two main classes of antibiotics: sulfonamides and diaminopyrimidines. Inhibition of these enzymes block the production of key precursors for nucleotides and amino acids. antibiotic_resistance ARO:3000714 folate synthesis enzyme targeted by antibiotic Enzymes in the folate synthesis pathway are targeted by two main classes of antibiotics: sulfonamides and diaminopyrimidines. Inhibition of these enzymes block the production of key precursors for nucleotides and amino acids. PMID:4387360 Enzymes in this pathway generate important precursors for macromolecules. While eukaryotes and prokaryotes both synthesize isoprenoids, many bacteria and notably mycobacteria use an alternative pathway that is targeted by antibiotics. antibiotic_resistance ARO:3000715 isoprenoid synthesis enzyme targeted by antibiotic Enzymes in this pathway generate important precursors for macromolecules. While eukaryotes and prokaryotes both synthesize isoprenoids, many bacteria and notably mycobacteria use an alternative pathway that is targeted by antibiotics. PMID:16321944 PMID:17430177 Mycolic acids are produced by mycobacteria. These fatty acids are required for the construction of cell walls. Enzymes that are targeted by antibiotics include synthases, elongases, and dehydrogenases. antibiotic_resistance ARO:3000716 mycolic acid synthesis enzyme targeted by antibiotic Mycolic acids are produced by mycobacteria. These fatty acids are required for the construction of cell walls. Enzymes that are targeted by antibiotics include synthases, elongases, and dehydrogenases. PMID:1656850 PMID:8143118 Signal peptidase I is a bacterial signal peptidase that cleaves signal peptides from translated proteins. These signal peptides direct proteins to their destination, and then must be cleaved in order to function. antibiotic_resistance ARO:3000717 antibiotic sensitive signal peptidase I Signal peptidase I is a bacterial signal peptidase that cleaves signal peptides from translated proteins. These signal peptides direct proteins to their destination, and then must be cleaved in order to function. PMID:15173160 PMID:21189343 PMID:7023361 MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB. antibiotic_resistance ARO:3000718 marR MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB. PMID:12027588 PMID:9333027 Isoprepnyl pyrophosphate removes a phosphate group that is added from the peptidoglycan subunit to permit its transfer across the cell membrane. The phosphate group must be removed before its incorporation into peptidoglycan macromolecules. antibiotic_resistance ARO:3000719 bacitracin sensitive isoprenyl pyrophosphate Isoprepnyl pyrophosphate removes a phosphate group that is added from the peptidoglycan subunit to permit its transfer across the cell membrane. The phosphate group must be removed before its incorporation into peptidoglycan macromolecules. PMID:18258256 PMID:4332017 PMID:4350651 PMID:6752975 The acyl-D-alanyl-D-alanine group is found at the terminal end of the pentapeptide chains of peptidoglycan subunits. Antibiotics that bind to this group block the addition of subunits, inhibiting peptidoglycan synthesis. This group is most accessible in Gram-postive bacteria. antibiotic_resistance ARO:3000720 acyl-D-alanyl-D-alanine The acyl-D-alanyl-D-alanine group is found at the terminal end of the pentapeptide chains of peptidoglycan subunits. Antibiotics that bind to this group block the addition of subunits, inhibiting peptidoglycan synthesis. This group is most accessible in Gram-postive bacteria. PMID:18258256 The cell wall is unique to bacteria and provides rigidity and protects the cell from lysis due to osmotic pressure. Its characteristic component is peptidoglycan, though cell wall structures vary significantly between Gram-positive and Gram-negative bacteria, as well as mycobacteria. antibiotic_resistance ARO:3000721 cell wall component targeted by antibiotic The cell wall is unique to bacteria and provides rigidity and protects the cell from lysis due to osmotic pressure. Its characteristic component is peptidoglycan, though cell wall structures vary significantly between Gram-positive and Gram-negative bacteria, as well as mycobacteria. PMID:4568761 Alanine racemase (alr) converts the natural L-alanine to the D-alanine required in the pentapeptide chains in peptidoglycan. It is found in both Gram-positive and Gram-negative bacteria. antibiotic_resistance ARO:3000722 cycloserine sensitive alr Alanine racemase (alr) converts the natural L-alanine to the D-alanine required in the pentapeptide chains in peptidoglycan. It is found in both Gram-positive and Gram-negative bacteria. PMID:19748470 PMID:4555420 D-Alanine synthetase (or ligase), also known as ddla, joins two D-alanines before their addition to the pentapeptide chains of peptidoglycan. It is found in both Gram-positive and Gram-negative bacteria. antibiotic_resistance ARO:3000723 cycloserine sensitive D-alanine synthetase D-Alanine synthetase (or ligase), also known as ddla, joins two D-alanines before their addition to the pentapeptide chains of peptidoglycan. It is found in both Gram-positive and Gram-negative bacteria. PMID:14479178 Pyruvyl transferase is responsible for the conversion of N-acetylglucosamine (NAG) to N-acetylmuramic acid (NAMA). NAMA is a part of the macromolecular backbone of peptidoglycans. Pyruvyl transferase is found in both Gram-positive and Gram-negative bacteria. antibiotic_resistance ARO:3000724 fosfomycin sensitive pyruvyl transferase (murA) Pyruvyl transferase is responsible for the conversion of N-acetylglucosamine (NAG) to N-acetylmuramic acid (NAMA). NAMA is a part of the macromolecular backbone of peptidoglycans. Pyruvyl transferase is found in both Gram-positive and Gram-negative bacteria. PMID:4605290 Arabinofuranosyltransferases allow for the polymerization of arabinose to form arabinan. Arabanan is required for formation of mycobacterial cell walls. antibiotic_resistance ARO:3000725 antibiotic sensitive aftA Arabinofuranosyltransferases allow for the polymerization of arabinose to form arabinan. Arabanan is required for formation of mycobacterial cell walls. PMID:18174142 PMID:19596878 The pentaglycyl bridge is part of Gram-positive peptidoglycan, allowing the formation of a thick and rigid cell wall. antibiotic_resistance ARO:3000726 pentaglycyl bridge The pentaglycyl bridge is part of Gram-positive peptidoglycan, allowing the formation of a thick and rigid cell wall. PMID:18258256 The larger of two ribosomal subunits that make up the 70S bacterial ribosome. antibiotic_resistance ARO:3000727 50S ribosomal subunit The larger of two ribosomal subunits that make up the 70S bacterial ribosome. PMID:10445875 PMID:16257828 The smaller of two ribosomal subunits that make up the 70S bacterial ribosome. antibiotic_resistance ARO:3000728 30S ribosomal subunit The smaller of two ribosomal subunits that make up the 70S bacterial ribosome. PMID:15755955 The ribosomal complex can be targeted by antibiotics that stabilize the entire complex and prevent further translation. These antibiotics target both subunits in the process of protein translation. antibiotic_resistance ARO:3000729 ribosomal complex The ribosomal complex can be targeted by antibiotics that stabilize the entire complex and prevent further translation. These antibiotics target both subunits in the process of protein translation. PMID:17515906 PMID:202460 Elongation factor G (EF-G) provides energy for the translocation step in protein synthesis. Antibiotics that target EF-G allow one round of translocation but prevent EF-G from dissociating from the ribosome-RNA complex. antibiotic_resistance ARO:3000730 elongation factor G Elongation factor G (EF-G) provides energy for the translocation step in protein synthesis. Antibiotics that target EF-G allow one round of translocation but prevent EF-G from dissociating from the ribosome-RNA complex. PMID:17980694 PMID:9678602 Elongation factor Tu is required for peptide elongation in bacterial protein synthesis. EF-Tu antibiotic_resistance ARO:3000731 elongation factor Tu Elongation factor Tu is required for peptide elongation in bacterial protein synthesis. PMID:364475 PMID:9678602 Isoleucyl-tRNA transferase recognizes isoleucine codons and works with the ribosome to incorporate isoleucine amino acids into polypeptide chains. It can be targeted by antibiotics that have an analog of isoleucine through competitive inhibition. ileS antibiotic_resistance ARO:3000732 antibiotic sensitive Isoleucyl-tRNA transferase Isoleucyl-tRNA transferase recognizes isoleucine codons and works with the ribosome to incorporate isoleucine amino acids into polypeptide chains. It can be targeted by antibiotics that have an analog of isoleucine through competitive inhibition. PMID:5803296 PMID:7929087 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling. gyrase A antibiotic_resistance ARO:3000733 fluoroquinolone sensitive gyrA DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling. PMID:1657531 PMID:9293187 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the beta-subunit is sufficient to inhibit DNA supercoiling. gyrase B gyrase beta subunit gyrase subunit B antibiotic_resistance ARO:3000734 antibiotic sensitive DNA topoisomerase subunit gyrB DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the beta-subunit is sufficient to inhibit DNA supercoiling. PMID:1657531 PMID:9293187 parC is a subunit of the DNA topoisomerase IV and is sensitive to fluoroquinolone. antibiotic_resistance ARO:3000735 Fluoroquinolone sensitive parC parC is a subunit of the DNA topoisomerase IV and is sensitive to fluoroquinolone. PMID:9293187 The rho transcription terminator factor moves along RNA as it is transcribed, unwinding the RNA from the DNA. It is also responsible for recognizing transcription termination pause sites, slowing down RNA polymerase and allowing mRNA to be released. antibiotic_resistance ARO:3000736 rho transcription terminator factor The rho transcription terminator factor moves along RNA as it is transcribed, unwinding the RNA from the DNA. It is also responsible for recognizing transcription termination pause sites, slowing down RNA polymerase and allowing mRNA to be released. PMID:21326894 PMID:8466900 The beta-subunit of RNA polymerase is targeted as a complex. When blocked, RNA strand elongation cannot continue after the first few nucleotides. antibiotic_resistance ARO:3000737 rifamycin sensitive beta-subunit of RNA polymerase (rpoB) The beta-subunit of RNA polymerase is targeted as a complex. When blocked, RNA strand elongation cannot continue after the first few nucleotides. PMID:15700959 Antibiotics can target DNA to cause strand breaks or prevent transcription. The activity of these antibiotics can be context dependent: some antibiotics are converted to an active form only in certain species, while others target DNA as it is being transcribed. DNA antibiotic_resistance ARO:3000738 deoxyribonucleic acid Antibiotics can target DNA to cause strand breaks or prevent transcription. The activity of these antibiotics can be context dependent: some antibiotics are converted to an active form only in certain species, while others target DNA as it is being transcribed. PMID:15685195 PMID:4941089 PMID:63969 RNA intron self-splicing action can be inhibited by antibiotics that target a G-binding site to compete with the guanosine cofactor. antibiotic_resistance ARO:3000739 RNA guanosine binding site RNA intron self-splicing action can be inhibited by antibiotics that target a G-binding site to compete with the guanosine cofactor. PMID:7509881 Many types of ribonucleic acids (RNAs) are targeted by antibiotics, including mRNA templates and ribosomal RNA. Some antibiotics target all RNAs and cause strand breaks. RNA antibiotic_resistance ARO:3000740 ribonucleic acid Many types of ribonucleic acids (RNAs) are targeted by antibiotics, including mRNA templates and ribosomal RNA. Some antibiotics target all RNAs and cause strand breaks. PMID:15685195 PMID:1701259 PMID:63969 PMID:7509881 DNA in the transcriptional complex is partially unwound, allowing antibiotics to target exposed bases and prevent DNA transcription. antibiotic_resistance ARO:3000741 transcription complex DNA DNA in the transcriptional complex is partially unwound, allowing antibiotics to target exposed bases and prevent DNA transcription. PMID:13948669 PMID:2410919 DNA in anaerobes are targeted by antibiotics that are converted to an active form in the anaerobe environment. For nitroimidazoles, the antibiotic is reduced to a highly oxidative intermediate that causes DNA oxidation and double-stranded breaks. antibiotic_resistance ARO:3000742 anaerobe DNA DNA in anaerobes are targeted by antibiotics that are converted to an active form in the anaerobe environment. For nitroimidazoles, the antibiotic is reduced to a highly oxidative intermediate that causes DNA oxidation and double-stranded breaks. PMID:8444678 This reductoisomerase is found in an alternate isoprenoid synthase pathway that is mevalonate independent. Isoprenoids are important precursors to many other macromolecules. This non-mevalonate pathway is used by plants and most bacteria, including mycobacteria, but not eukaryotes, allowing for selectivea action. Staphylococcus aureus and some other Gram-positive bacteria use a mevalonate-dependent pathway, and are resistant against 1-deoxy-D-xylose 5-phosphate reductoisomerase inhibitors. antibiotic_resistance ARO:3000743 1-deoxy-D-xylulose 5-phosphate reductoisomerase This reductoisomerase is found in an alternate isoprenoid synthase pathway that is mevalonate independent. Isoprenoids are important precursors to many other macromolecules. This non-mevalonate pathway is used by plants and most bacteria, including mycobacteria, but not eukaryotes, allowing for selectivea action. Staphylococcus aureus and some other Gram-positive bacteria use a mevalonate-dependent pathway, and are resistant against 1-deoxy-D-xylose 5-phosphate reductoisomerase inhibitors. PMID:16321944 PMID:17430177 Dihydropteroate synthase catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, and a precursor of many nucleotides and amino acids. Inhibiting dihydropteroate leads to slow cell death, as bacteria can survive on existing folate storages for a few generations. antibiotic_resistance ARO:3000744 antibiotic sensitive dihydropteroate synthase Dihydropteroate synthase catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, and a precursor of many nucleotides and amino acids. Inhibiting dihydropteroate leads to slow cell death, as bacteria can survive on existing folate storages for a few generations. PMID:12111724 Dihydrofolate reductase synthesizes the co-enzyme tetrahydrofolic acid, which is also an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. FolA antibiotic_resistance ARO:3000745 antibiotic sensitive dihydrofolate reductase Dihydrofolate reductase synthesizes the co-enzyme tetrahydrofolic acid, which is also an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. PMID:12781525 MepR is an upstream repressor of MepA in Staphylococcus aureus. It is part of the mepRAB operon. mepR antibiotic_resistance ARO:3000746 mepR MepR is an upstream repressor of MepA in Staphylococcus aureus. It is part of the mepRAB operon. PMID:15855507 PMID:15855508 PMID:16569840 mepR Mef efflux pumps are MFS-type transporters that confer macrolide resistance in Streptococcus pneumoniae. antibiotic_resistance ARO:3000747 mef Mef efflux pumps are MFS-type transporters that confer macrolide resistance in Streptococcus pneumoniae. PMID:16189099 Subunits of efflux proteins that pump antibiotic out of a cell to confer resistance. antibiotic_resistance ARO:3000748 subunit of efflux pump conferring antibiotic resistance Penicillin-binding proteins (PBPs) are responsible for transpeptidation, joining subunits to form peptidoglycan. They are numbered according to descending molecular weight, and may vary between species. These numbers represent the PBPs of E. coli. Inhibition of the larger PBPs responsible for transpeptidation (1-3) are lethal. Smaller PBPs (4-6) are involed in carboxypeptidation; inhibition of these is non-lethal. antibiotic_resistance ARO:3000749 beta-lactam sensitive penicillin-binding protein Penicillin-binding proteins (PBPs) are responsible for transpeptidation, joining subunits to form peptidoglycan. They are numbered according to descending molecular weight, and may vary between species. These numbers represent the PBPs of E. coli. Inhibition of the larger PBPs responsible for transpeptidation (1-3) are lethal. Smaller PBPs (4-6) are involed in carboxypeptidation; inhibition of these is non-lethal. PMID:3055170 A protein, either a histidine kinase or a response regulator, that is part of a two-component regulatory system that directly or indirectly change rates of antibiotic efflux. antibiotic_resistance ARO:3000750 protein of two-component regulatory system modulating antibiotic efflux AbeM is an multidrug efflux pump found in Acinetobacter baumannii. abeM antibiotic_resistance ARO:3000753 abeM AbeM is an multidrug efflux pump found in Acinetobacter baumannii. PMID:16189122 abeM The bacterial 23S rRNA, at the P site of the 50S subunit, has peptidyl transferase activity and is responsible for peptide synthesis and elongation. antibiotic_resistance ARO:3000754 antibiotic sensitive peptidyl transferase (23S rRNA) The bacterial 23S rRNA, at the P site of the 50S subunit, has peptidyl transferase activity and is responsible for peptide synthesis and elongation. PMID:10445875 PMID:16257828 PMID:16569865 The 16S rRNA of the 30S ribosomal subunit helps to stabilize the aminoacyl-tRNAs for pairing with the mRNA codons. Some antibiotics (aminoglycosides) that target the 16S rRNA lead to mRNA misreading as well as premature termination. Other antibiotics (tetracyclines) that target the 16S rRNA prevent incoming charged-tRNAs from binding to the ribosome's A-site, stopping elongation. antibiotic_resistance ARO:3000755 antibiotic sensitive 16S rRNA The 16S rRNA of the 30S ribosomal subunit helps to stabilize the aminoacyl-tRNAs for pairing with the mRNA codons. Some antibiotics (aminoglycosides) that target the 16S rRNA lead to mRNA misreading as well as premature termination. Other antibiotics (tetracyclines) that target the 16S rRNA prevent incoming charged-tRNAs from binding to the ribosome's A-site, stopping elongation. PMID:9662506 The P-site of the ribosome binds the peptidyl-tRNA with the growing polypeptide chain. Antibiotics that target the P-site block fMet-tRNA from entering, thus inhibiting peptide elongation. antibiotic_resistance ARO:3000756 30S ribosomal subunit P-site The P-site of the ribosome binds the peptidyl-tRNA with the growing polypeptide chain. Antibiotics that target the P-site block fMet-tRNA from entering, thus inhibiting peptide elongation. PMID:15755955 The P-site of the ribosome binds the peptidyl-tRNA with the growing polypeptide chain, and is a common target for many antibiotics that inhibit the 50S ribosomal subunit. Some antibiotics (oxazolidinones) block the 50S subunit from interacting with the 30S subunit to prevent the formation of the ribosomal complex. Other antibiotics (thiostrepton) block the 50S subunit from interacting with elongation factors G and Tu (EF-G, Ef-Tu), preventing GTP-dependent reactions of peptidyl transferase, and translocation, respectively. Other antibiotics (macrolides) prevent protein translocation. antibiotic_resistance ARO:3000757 50S ribosomal subunit P-site The P-site of the ribosome binds the peptidyl-tRNA with the growing polypeptide chain, and is a common target for many antibiotics that inhibit the 50S ribosomal subunit. Some antibiotics (oxazolidinones) block the 50S subunit from interacting with the 30S subunit to prevent the formation of the ribosomal complex. Other antibiotics (thiostrepton) block the 50S subunit from interacting with elongation factors G and Tu (EF-G, Ef-Tu), preventing GTP-dependent reactions of peptidyl transferase, and translocation, respectively. Other antibiotics (macrolides) prevent protein translocation. PMID:15700955 PMID:15755955 PMID:795651 Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme in the non-mevalonate pathway for isoprenoid synthesis. It is active against enterobacteria, but not against Gram-positive bacteria or anaerobes. pubchem.compound:572 antibiotic_resistance ARO:3000758 fosmidomycin Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme in the non-mevalonate pathway for isoprenoid synthesis. It is active against enterobacteria, but not against Gram-positive bacteria or anaerobes. PMID:10477522 Fusidic acid is the only commercially available fusidane, a group of steroid-like antibiotics. It is most active against Gram-positive bacteria, and acts by inhibiting elongation factor G to block protein synthesis. pubchem.compound:3000226 fucidin antibiotic_resistance ARO:3000759 fusidic acid Fusidic acid is the only commercially available fusidane, a group of steroid-like antibiotics. It is most active against Gram-positive bacteria, and acts by inhibiting elongation factor G to block protein synthesis. PMID:17980694 PMID:7730233 Cycloserine is an anti-mycobacterial agent, and is active against enterobacteria, streptococci, M. tuberculosis, Staphylococcus aureus, and many Gram-negative and Gram-positive bacteria. It inhibits cell wall biosynthesis. pubchem.compound:6234 antibiotic_resistance ARO:3000760 cycloserine Cycloserine is an anti-mycobacterial agent, and is active against enterobacteria, streptococci, M. tuberculosis, Staphylococcus aureus, and many Gram-negative and Gram-positive bacteria. It inhibits cell wall biosynthesis. PMID:14479178 PMID:4555420 Mecillinam is a broad-spectrum beta-lactam antibiotic that was semi-synthetically derived to have a different drug centre, being a 6-alpha-amidinopenicillanate instead of a 6-alpha-acylaminopenicillanate. Contrasting most beta-lactam drugs, mecillinam is most active against Gram-negative bacteria. It binds specifically to penicillin binding protein 2 (PBP2). pubchem.compound:36273 Selexid Selexidin amdinocillin antibiotic_resistance ARO:3000761 mecillinam Mecillinam is a broad-spectrum beta-lactam antibiotic that was semi-synthetically derived to have a different drug centre, being a 6-alpha-amidinopenicillanate instead of a 6-alpha-acylaminopenicillanate. Contrasting most beta-lactam drugs, mecillinam is most active against Gram-negative bacteria. It binds specifically to penicillin binding protein 2 (PBP2). PMID:6310995 Pefloxacin is structurally and functionally similar to norfloxacin. It is poorly active against mycobacteria, while anaerobes are resistant. pubchem.compound:51081 antibiotic_resistance ARO:3000762 pefloxacin Pefloxacin is structurally and functionally similar to norfloxacin. It is poorly active against mycobacteria, while anaerobes are resistant. PMID:2663414 EmbC is an arabinosyltransferase involved in lipoarabinomannan synthesis. antibiotic_resistance ARO:3000763 antibiotic sensitive embC EmbC is an arabinosyltransferase involved in lipoarabinomannan synthesis. PMID:18174142 EmbA is an arabinosyltransferase that works as a heterodimer with EmbB. It is involved in the synthesis of arabinogalactan, a component of the mycobacterial cell wall. antibiotic_resistance ARO:3000764 antibiotic sensitive embA EmbA is an arabinosyltransferase that works as a heterodimer with EmbB. It is involved in the synthesis of arabinogalactan, a component of the mycobacterial cell wall. PMID:18174142 EmbB is an arabinosyltransferase that works as a heterodimer with EmbA. It is involved in the synthesis of arabinogalactan, a component of the mycobacterial cell wall. antibiotic_resistance ARO:3000765 antibiotic sensitive embB EmbB is an arabinosyltransferase that works as a heterodimer with EmbA. It is involved in the synthesis of arabinogalactan, a component of the mycobacterial cell wall. PMID:18174142 Topoisomerases are responsible for winding and relaxing supercoiled DNA. The subunits of gyrase (gyrA, gyrB) and topoisomerase IV (parC, parE, parY) are targeted by antibiotics. antibiotic_resistance ARO:3000766 antibiotic sensitive topoisomerase subunit Avoparcin is a glycopeptide antibiotic that is an analog of vancomycin. It was formally used to treat animals, but has since been banned because of its selection for vancomycin-resistant enterococci. pubchem.compound:16132294 antibiotic_resistance ARO:3000767 avoparcin Avoparcin is a glycopeptide antibiotic that is an analog of vancomycin. It was formally used to treat animals, but has since been banned because of its selection for vancomycin-resistant enterococci. PMID:2532132 PMID:9458981 AbeS in an efflux pump of the SMR family of transporters found in Acinetobacter baumannii. abeS antibiotic_resistance ARO:3000768 abeS AbeS in an efflux pump of the SMR family of transporters found in Acinetobacter baumannii. PMID:19770280 abeS PatA-PatB is an efflux protein complex that is associated with fluoroquinolone resistance in Streptococcus pneumoniae. Experiments indicate that PatA and PatB form a heterodimeric transporter. PatA-PatB PatA/PatB PatAB antibiotic_resistance ARO:3000769 PatA-PatB PatA-PatB is an efflux protein complex that is associated with fluoroquinolone resistance in Streptococcus pneumoniae. Experiments indicate that PatA and PatB form a heterodimeric transporter. PMID:20709735 PMID:20937787 PatA-PatB AdeABC is an RND multidrug efflux system in Acinetobacter species, notably A. baunmannii. AdeA is a membrane fusion protein, AdeB is the inner membrane transporter, and AdeC is the outer membrane factor. It confers resistance to tigecycline. antibiotic_resistance ARO:3000770 AdeABC AdeABC is an RND multidrug efflux system in Acinetobacter species, notably A. baunmannii. AdeA is a membrane fusion protein, AdeB is the inner membrane transporter, and AdeC is the outer membrane factor. It confers resistance to tigecycline. PMID:17363424 PMID:21173183 AdeFGH is a RND multidrug efflux pump expressed in Acinetobacter baumannii. It confers resistance to fluoroquinolone, tetracycline, tigecycline, chloramphenicol, clindamycin, trimethoprim, and sulfamethoxazole. antibiotic_resistance ARO:3000771 AdeFGH AdeFGH is a RND multidrug efflux pump expressed in Acinetobacter baumannii. It confers resistance to fluoroquinolone, tetracycline, tigecycline, chloramphenicol, clindamycin, trimethoprim, and sulfamethoxazole. PMID:20696879 PMID:21377839 AdeIJK is a RND multidrug efflux pump expressed in Acinetobacter baumannii. It contributes to resistance for beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolone, fusidic acid, novobiocin, rifampicin, trimethoprim, acridine, pyronine, and safranin. antibiotic_resistance ARO:3000772 AdeIJK AdeIJK is a RND multidrug efflux pump expressed in Acinetobacter baumannii. It contributes to resistance for beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolone, fusidic acid, novobiocin, rifampicin, trimethoprim, acridine, pyronine, and safranin. PMID:18086852 CmeABC is a multidrug efflux pump in Campylobacter jejuni. Its overexpression led to enhanced resistance to ciprofloxacin, norfloxacin, cefotaxime, fusidic acid, and erythromycin. CmeA acts as the periplasmic fusion protein, CmeB is the inner membrane transporter, and CmeC is an outer membrane protein. antibiotic_resistance ARO:3000773 CmeABC CmeABC is a multidrug efflux pump in Campylobacter jejuni. Its overexpression led to enhanced resistance to ciprofloxacin, norfloxacin, cefotaxime, fusidic acid, and erythromycin. CmeA acts as the periplasmic fusion protein, CmeB is the inner membrane transporter, and CmeC is an outer membrane protein. PMID:15728904 PMID:27651364 AdeA is the membrane fusion protein of the multidrug efflux complex AdeABC. adeA antibiotic_resistance ARO:3000774 adeA AdeA is the membrane fusion protein of the multidrug efflux complex AdeABC. PMID:21173183 adeA AdeB is the multidrug transporter of the adeABC efflux system. adeB antibiotic_resistance ARO:3000775 adeB AdeB is the multidrug transporter of the adeABC efflux system. PMID:21173183 adeB AdeF is the membrane fusion protein of the multidrug efflux complex AdeFGH. adeF antibiotic_resistance ARO:3000777 adeF AdeF is the membrane fusion protein of the multidrug efflux complex AdeFGH. PMID:20696879 adeF AdeG is the inner membrane transporter of the AdeFGH multidrug efflux complex. adeG antibiotic_resistance ARO:3000778 adeG AdeG is the inner membrane transporter of the AdeFGH multidrug efflux complex. PMID:21377839 adeG AdeH is the outer membrane channel protein of the AdeFGH multidrug efflux complex. adeH antibiotic_resistance ARO:3000779 adeH AdeH is the outer membrane channel protein of the AdeFGH multidrug efflux complex. PMID:20696879 adeH AdeI is the membrane fusion protein of the AdeIJK multidrug efflux complex. adeI antibiotic_resistance ARO:3000780 adeI AdeI is the membrane fusion protein of the AdeIJK multidrug efflux complex. PMID:18086852 adeI AdeJ is a RND efflux protein that acts as the inner membrane transporter of the AdeIJK efflux complex. It has 57% identity with E. coli AcrB. adeJ antibiotic_resistance ARO:3000781 adeJ AdeJ is a RND efflux protein that acts as the inner membrane transporter of the AdeIJK efflux complex. It has 57% identity with E. coli AcrB. PMID:18086852 adeJ AdeK is the outer membrane factor protein in the adeIJK multidrug efflux complex. adeK antibiotic_resistance ARO:3000782 adeK AdeK is the outer membrane factor protein in the adeIJK multidrug efflux complex. PMID:18086852 adeK CmeA is the membrane fusion protein of the CmeABC multidrug efflux complex. cmeA antibiotic_resistance ARO:3000783 cmeA CmeA is the membrane fusion protein of the CmeABC multidrug efflux complex. PMID:15728904 cmeA CmeB is the inner membrane transporter the CmeABC multidrug efflux complex. cmeB antibiotic_resistance ARO:3000784 cmeB CmeB is the inner membrane transporter the CmeABC multidrug efflux complex. PMID:15728904 cmeB CmeC is the outer membrane channel protein of the CmeABC multidrug efflux complex. cmeC antibiotic_resistance ARO:3000785 cmeC CmeC is the outer membrane channel protein of the CmeABC multidrug efflux complex. PMID:15728904 cmeC MdsABC, or GesABC, is a RND-type efflux complex found in Salmonella. In addition to its metal-efflux system, GesABC is also capable of exporting beta-lactams, chloramphenicol, and thiamphenicol. GesB is the inner membrane transporter and is similar to MexF; GesA is the membrane-fusion protein, and GesC is the outer membrane factor. GesABC STM0352 STM0351 STM0350 antibiotic_resistance ARO:3000786 MdsABC MdsABC, or GesABC, is a RND-type efflux complex found in Salmonella. In addition to its metal-efflux system, GesABC is also capable of exporting beta-lactams, chloramphenicol, and thiamphenicol. GesB is the inner membrane transporter and is similar to MexF; GesA is the membrane-fusion protein, and GesC is the outer membrane factor. PMID:17919284 PMID:20497225 MdtABC-TolC is a multidrug efflux system in Gram-negative bacteria, including E. coli and Salmonella. MdtA is a membrane fusion protein; TolC is the outer membrane channel; MdtBC form a drug transporter. In the absence of MdtB, the MdtAC-TolC has narrower drug specificity, leading to the loss of novobiocin resistance, for example. MdtABC-TolC antibiotic_resistance ARO:3000787 MdtABC-TolC MdtABC-TolC is a multidrug efflux system in Gram-negative bacteria, including E. coli and Salmonella. MdtA is a membrane fusion protein; TolC is the outer membrane channel; MdtBC form a drug transporter. In the absence of MdtB, the MdtAC-TolC has narrower drug specificity, leading to the loss of novobiocin resistance, for example. PMID:12107133 PMID:17933888 MdtABC-TolC MdtEF-TolC is a multidrug efflux complex in Gram-negative bacteria, including E. coli. MdtE is the membrane fusion protein, MdtF is the inner membrane transporter, while TolC is the outer membrane channel. MdtEF-TolC YhiUV-TolC antibiotic_resistance ARO:3000788 MdtEF-TolC MdtEF-TolC is a multidrug efflux complex in Gram-negative bacteria, including E. coli. MdtE is the membrane fusion protein, MdtF is the inner membrane transporter, while TolC is the outer membrane channel. PMID:14973023 MdtEF-TolC MdsA is the membrane fusion protein of the multidrug and metal efflux complex MdsABC. gesA mdsA antibiotic_resistance ARO:3000789 mdsA MdsA is the membrane fusion protein of the multidrug and metal efflux complex MdsABC. PMID:17919284 PMID:20497225 mdsA MdsB is the inner membrane transporter of the multidrug and metal efflux complex MdsABC. mdsB corresponds to 1 locus in Pseudomonas aeruginosa PAO1 (gene name: mexQ) and 2 loci in Pseudomonas aeruginosa LESB58. gesB mdsB antibiotic_resistance ARO:3000790 mdsB MdsB is the inner membrane transporter of the multidrug and metal efflux complex MdsABC. mdsB corresponds to 1 locus in Pseudomonas aeruginosa PAO1 (gene name: mexQ) and 2 loci in Pseudomonas aeruginosa LESB58. PMID:17919284 PMID:20497225 mdsB MdsC is the outer membrane channel of the multidrug and metal efflux complex MdsABC. gesC mdsC antibiotic_resistance ARO:3000791 mdsC MdsC is the outer membrane channel of the multidrug and metal efflux complex MdsABC. PMID:17919284 PMID:20497225 mdsC MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. mdtA yegM antibiotic_resistance ARO:3000792 mdtA MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. PMID:12107133 mdtA MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. mdtB yegN antibiotic_resistance ARO:3000793 mdtB MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. PMID:12107133 mdtB MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58. mdtC yegO antibiotic_resistance ARO:3000794 mdtC MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58. PMID:12107133 mdtC MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. YhiU mdtE antibiotic_resistance ARO:3000795 mdtE MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. PMID:23380871 mdtE MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex. YhiV mdtF antibiotic_resistance ARO:3000796 mdtF MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex. PMID:11914367 mdtF MexCD-OprJ is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexC is the membrane fusion protein; MexD is the inner membrane transporter; and OprJ is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, and macrolides. MexCD-OprJ is typically quiescent in wild-type cells, with expression following mutation of the nfxB gene that is divergently transcribed from the mexCD-oprJ operon and encodes a repressor of mexCD-oprJ expression. Expression of mexCD–oprJ is controlled by a single known regulator, the NfxB repressor encoded by the nfxB gene, which is transcribed divergently from the efflux genes. antibiotic_resistance ARO:3000797 MexCD-OprJ MexCD-OprJ is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexC is the membrane fusion protein; MexD is the inner membrane transporter; and OprJ is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, and macrolides. MexCD-OprJ is typically quiescent in wild-type cells, with expression following mutation of the nfxB gene that is divergently transcribed from the mexCD-oprJ operon and encodes a repressor of mexCD-oprJ expression. Expression of mexCD–oprJ is controlled by a single known regulator, the NfxB repressor encoded by the nfxB gene, which is transcribed divergently from the efflux genes. PMID:9449262 MexEF-OprN is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexE is the membrane fusion protein; MexF is the inner membrane transporter; and OprN is the outer membrane channel. MexEF-OprN is associated with resistance to fluoroquinolones, chloramphenicol, and trimethoprim. Regulation of mexEF-oprN operon expression is multifaceted with the MexT activator being one of the most prominent regulatory proteins. MexEF-OprN is the only positively regulated RND pump of P. aeruginosa. NfxC mutant antibiotic_resistance ARO:3000798 MexEF-OprN MexEF-OprN is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexE is the membrane fusion protein; MexF is the inner membrane transporter; and OprN is the outer membrane channel. MexEF-OprN is associated with resistance to fluoroquinolones, chloramphenicol, and trimethoprim. Regulation of mexEF-oprN operon expression is multifaceted with the MexT activator being one of the most prominent regulatory proteins. MexEF-OprN is the only positively regulated RND pump of P. aeruginosa. PMID:10515918 MexGHI-OpmD is an efflux complex expressed in Pseudomonas aeruginosa. MexG is a membrane protein required for drug export; MexH is the membrane fusion protein; MexI is the inner membrane transporter; and MexJ is the outer membrane channel protein. MexGHI-OpmD confers resistance to vanadium, norfloxacin, and acriflavin. MexGHI-OmpD MexGHI-OpmD antibiotic_resistance ARO:3000799 MexGHI-OpmD MexGHI-OpmD is an efflux complex expressed in Pseudomonas aeruginosa. MexG is a membrane protein required for drug export; MexH is the membrane fusion protein; MexI is the inner membrane transporter; and MexJ is the outer membrane channel protein. MexGHI-OpmD confers resistance to vanadium, norfloxacin, and acriflavin. PMID:12917802 PMID:15817779 MexGHI-OpmD MexC is the membrane fusion protein of the MexCD-OprJ multidrug efflux complex. MexC antibiotic_resistance ARO:3000800 MexC MexC is the membrane fusion protein of the MexCD-OprJ multidrug efflux complex. PMID:9449262 MexC MexD is the multidrug inner membrane transporter of the MexCD-OprJ complex. MexD antibiotic_resistance ARO:3000801 MexD MexD is the multidrug inner membrane transporter of the MexCD-OprJ complex. PMID:8878035 PMID:9449262 MexD OprJ is the outer membrane channel component of the MexCD-OprJ multidrug efflux complex. OprJ antibiotic_resistance ARO:3000802 OprJ OprJ is the outer membrane channel component of the MexCD-OprJ multidrug efflux complex. PMID:9449262 OprJ MexE is the membrane fusion protein of the MexEF-OprN multidrug efflux complex. MexE antibiotic_resistance ARO:3000803 MexE MexE is the membrane fusion protein of the MexEF-OprN multidrug efflux complex. PMID:10515918 MexE MexF is the multidrug inner membrane transporter of the MexEF-OprN complex. mexF corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: mexF/mexB) and 4 loci in Pseudomonas aeruginosa LESB58 (gene name: mexD/mexB). MexF antibiotic_resistance ARO:3000804 MexF MexF is the multidrug inner membrane transporter of the MexEF-OprN complex. mexF corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: mexF/mexB) and 4 loci in Pseudomonas aeruginosa LESB58 (gene name: mexD/mexB). PMID:10515918 MexF OprN is the outer membrane channel component of the MexEF-OprN multidrug efflux complex. OprN antibiotic_resistance ARO:3000805 OprN OprN is the outer membrane channel component of the MexEF-OprN multidrug efflux complex. PMID:10515918 OprN MexG is a membrane protein required for MexGHI-OpmD efflux activity. MexG antibiotic_resistance ARO:3000806 MexG MexG is a membrane protein required for MexGHI-OpmD efflux activity. PMID:12917802 PMID:15817779 MexG MexH is the membrane fusion protein of the efflux complex MexGHI-OpmD. MexH antibiotic_resistance ARO:3000807 MexH MexH is the membrane fusion protein of the efflux complex MexGHI-OpmD. PMID:12917802 PMID:15817779 MexH MexI is the inner membrane transporter of the efflux complex MexGHI-OpmD. MexI antibiotic_resistance ARO:3000808 MexI MexI is the inner membrane transporter of the efflux complex MexGHI-OpmD. PMID:12917802 PMID:15817779 MexI OpmD is the outer membrane channel protein of the efflux complex MexGHI-OpmD. OpmD ompD antibiotic_resistance ARO:3000809 OpmD OpmD is the outer membrane channel protein of the efflux complex MexGHI-OpmD. PMID:12177331 PMID:12917802 PMID:12937010 PMID:15817779 OpmD MtrC is the membrane fusion protein of the MtrCDE multidrug efflux complex. mtrC antibiotic_resistance ARO:3000810 mtrC MtrC is the membrane fusion protein of the MtrCDE multidrug efflux complex. PMID:14500476 mtrC MtrD is the inner membrane multidrug transporter of the MtrCDE efflux complex. mtrD antibiotic_resistance ARO:3000811 mtrD MtrD is the inner membrane multidrug transporter of the MtrCDE efflux complex. PMID:14500476 PMID:9245801 mtrD MtrE is an outer membrane exporter protein that is part of the MtrCDE multidrug efflux complex. mtrE antibiotic_resistance ARO:3000812 mtrE MtrE is an outer membrane exporter protein that is part of the MtrCDE multidrug efflux complex. PMID:14500476 mtrE MexS is a suppressor of MexT, which is an activator of the multidrug pump MexEF-OprN. Mutations in MexS lead to multidrug resistance. MexS PA2491 nfxC qrh antibiotic_resistance ARO:3000813 MexS MexS is a suppressor of MexT, which is an activator of the multidrug pump MexEF-OprN. Mutations in MexS lead to multidrug resistance. PMID:11040437 PMID:15687188 PMID:26833155 MexS MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN, OprD, and MexS. MexT antibiotic_resistance ARO:3000814 MexT MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN, OprD, and MexS. PMID:10515918 PMID:11040437 PMID:26833155 MexT MgrA, also known as NorR, is a regulator for norA, norB, and tet38. It is a positive regulator for norA expression, but is a direct repressor for norB and an indirect repressor of tet38. mgrA norR antibiotic_resistance ARO:3000815 mgrA MgrA, also known as NorR, is a regulator for norA, norB, and tet38. It is a positive regulator for norA expression, but is a direct repressor for norB and an indirect repressor of tet38. PMID:12730173 PMID:15774883 mgrA MtrA is a transcriptional activator of the MtrCDE multidrug efflux pump of Neisseria gonorrhoeae. mtrA antibiotic_resistance ARO:3000816 mtrA MtrA is a transcriptional activator of the MtrCDE multidrug efflux pump of Neisseria gonorrhoeae. PMID:10417654 mtrA MtrR is a repressor of mtrCDE expression. Mutations in mtrR increase multidrug resistance. mtrR antibiotic_resistance ARO:3000817 mtrR MtrR is a repressor of mtrCDE expression. Mutations in mtrR increase multidrug resistance. PMID:7773394 mtrR NalC is a repressor of PA3720-PA3719, which are positive regulators of MexAB-OprM. Thus, nalC mutants confer multidrug resistance. PA3721 nalC antibiotic_resistance ARO:3000818 nalC NalC is a repressor of PA3720-PA3719, which are positive regulators of MexAB-OprM. Thus, nalC mutants confer multidrug resistance. PMID:15387820 PMID:27060003 PMID:27412168 nalC NalD is a repressor of MexAB-OprM. Mutations lead to multidrug resistance and MexAB-OprM overexpression. PA3574 nalD antibiotic_resistance ARO:3000819 nalD NalD is a repressor of MexAB-OprM. Mutations lead to multidrug resistance and MexAB-OprM overexpression. PMID:15855496 nalD NfxB is a repressor of the efflux pump mexCD-oprJ and itself (NfxB binds upstream of the nfxB gene and negatively regulates its own expression). Increased expression of MexCD–OprJ brought about by mutations in NfxB. antibiotic_resistance ARO:3000820 NfxB NfxB is a repressor of the efflux pump mexCD-oprJ and itself (NfxB binds upstream of the nfxB gene and negatively regulates its own expression). Increased expression of MexCD–OprJ brought about by mutations in NfxB. PMID:12727072 PMID:1330820 PMID:23924707 PMID:8878035 PhoPQ is a two-component regulatory system. phoP is phosphorylated by phoQ at a low [mg2+], activating the repressor. Its part of a two component regulating system that activates the PmrA/B system which has downstream effects, leading to Antimicrobial resistance in many pathogens. In Salmonella, phoP bind to macAB ABC transporter and represses it. In Escherichia coli, phoPQ regulates arnA expression. In Pseudomonas aeruginosa, phoPQ regulates OprH expression. phoPQ have other roles in other species. PhoP/Q antibiotic_resistance ARO:3000821 phoPQ PhoPQ is a two-component regulatory system. phoP is phosphorylated by phoQ at a low [mg2+], activating the repressor. Its part of a two component regulating system that activates the PmrA/B system which has downstream effects, leading to Antimicrobial resistance in many pathogens. In Salmonella, phoP bind to macAB ABC transporter and represses it. In Escherichia coli, phoPQ regulates arnA expression. In Pseudomonas aeruginosa, phoPQ regulates OprH expression. phoPQ have other roles in other species. PMID:11222580 PMID:16359323 PMID:20843473 PMID:21131322 PmrA is a MFS-type efflux pump expressed in Streptococcus pneumoniae that confers low-level resistance to norfloxacin, ciprofloxacin, and acriflavine. pmrA antibiotic_resistance ARO:3000822 pmrA PmrA is a MFS-type efflux pump expressed in Streptococcus pneumoniae that confers low-level resistance to norfloxacin, ciprofloxacin, and acriflavine. PMID:11850265 PMID:15205413 PMID:20709735 PMID:9869592 pmrA RamA (resistance antibiotic multiple) is a positive regulator of AcrAB-TolC and leads to high level multidrug resistance in Klebsiella pneumoniae, Salmonella enterica, and Enterobacter aerugenes, increasing the expression of both the mar operon as well as AcrAB. RamA also decreases OmpF expression. ramA antibiotic_resistance ARO:3000823 ramA RamA (resistance antibiotic multiple) is a positive regulator of AcrAB-TolC and leads to high level multidrug resistance in Klebsiella pneumoniae, Salmonella enterica, and Enterobacter aerugenes, increasing the expression of both the mar operon as well as AcrAB. RamA also decreases OmpF expression. PMID:12936981 PMID:15215103 PMID:18577510 PMID:7551053 ramA RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. antibiotic_resistance ARO:3000824 ramR RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. PMID:18443112 PMID:19104017 PMID:19270312 PMID:19778917 The robA protein is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. robA antibiotic_resistance ARO:3000825 rob The robA protein is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. PMID:12791142 PMID:9324261 SdiA is a cell division regulator that is also a positive regulator of AcrAB only when it's expressed from a plasmid. When the sdiA gene is on the chromosome, it has no effect on expression of acrAB. sdiA antibiotic_resistance ARO:3000826 sdiA SdiA is a cell division regulator that is also a positive regulator of AcrAB only when it's expressed from a plasmid. When the sdiA gene is on the chromosome, it has no effect on expression of acrAB. PMID:11929524 PMID:20126629 sdiA SoxRS is a two-component regulator part of the superoxide stress response. It is a positive regulator for many multidrug efflux pumps. antibiotic_resistance ARO:3000827 soxRS SoxRS is a two-component regulator part of the superoxide stress response. It is a positive regulator for many multidrug efflux pumps. PMID:7986007 BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. baeR antibiotic_resistance ARO:3000828 baeR BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. PMID:12107133 PMID:37345941 baeR BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity, BaeS is not necessary for overexpressed BaeR to confer resistance. baeS antibiotic_resistance ARO:3000829 baeS BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity, BaeS is not necessary for overexpressed BaeR to confer resistance. PMID:12107134 PMID:15716448 PMID:37345941 baeS CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR, which promotes efflux complex expression. cpxA antibiotic_resistance ARO:3000830 cpxA CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR, which promotes efflux complex expression. PMID:22496764 cpxA CpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA, a sensor kinase. CpxR is also directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. antibiotic_resistance ARO:3000831 CpxR CpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA, a sensor kinase. CpxR is also directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. PMID:22496764 PMID:25294881 PMID:27736975 EvgA, when phosphorylated, is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner, it can be phosphorylated in the absence of EvgS when overexpressed. evgA antibiotic_resistance ARO:3000832 evgA EvgA, when phosphorylated, is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner, it can be phosphorylated in the absence of EvgS when overexpressed. PMID:12951338 evgA EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. evgS rocS1 antibiotic_resistance ARO:3000833 evgS EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PMID:11914367 evgS PhoP is a direct repressor of the macAB efflux genes. antibiotic_resistance ARO:3000834 phoP PhoP is a direct repressor of the macAB efflux genes. PMID:24412662 PhoQ is a sensor protein that is induced by low Mg2+ concentrations. When activated, PhoQ donates a phosphate to activate PhoP. antibiotic_resistance ARO:3000835 phoQ PhoQ is a sensor protein that is induced by low Mg2+ concentrations. When activated, PhoQ donates a phosphate to activate PhoP. PMID:24412662 SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps. In Pseudomonas aeruginosa, which lacks SoxS, SoxR is able to directly upregulate the expression of the MexGHI-OpmD efflux pump. antibiotic_resistance ARO:3000836 soxR SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps. In Pseudomonas aeruginosa, which lacks SoxS, SoxR is able to directly upregulate the expression of the MexGHI-OpmD efflux pump. PMID:15845502 PMID:21226770 SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. antibiotic_resistance ARO:3000837 soxS SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. PMID:15845502 PMID:7986007 PMID:8821940 PMID:9324261 ArlR is a response regulator that binds to the norA promoter to activate expression. ArlR must first be phosphorylated by ArlS. arlR antibiotic_resistance ARO:3000838 arlR ArlR is a response regulator that binds to the norA promoter to activate expression. ArlR must first be phosphorylated by ArlS. PMID:10633099 arlR ArlS is a protein histidine kinase that phosphorylates ArlR, a promoter for norA expression. arlS antibiotic_resistance ARO:3000839 arlS ArlS is a protein histidine kinase that phosphorylates ArlR, a promoter for norA expression. PMID:10633099 arlS JOHN-1 is an Ambler class B carbapenem-hydrolysing beta-lactamase from Flavobacterium johnsoniae. JOHN-1 antibiotic_resistance ARO:3000840 JOHN-1 JOHN-1 is an Ambler class B carbapenem-hydrolysing beta-lactamase from Flavobacterium johnsoniae. PMID:12562690 JOHN-1 CGB-1 is an Ambler class B beta-lactamase that mediates resistance for carbapenems in Chryseobacterium gleum. CGB-1 antibiotic_resistance ARO:3000841 CGB-1 CGB-1 is an Ambler class B beta-lactamase that mediates resistance for carbapenems in Chryseobacterium gleum. PMID:12183230 CGB-1 EBR-1 is an Ambler class B beta-lactamase found in Empedobacter brevis and is known to mediate the hydrolysis of penicillins, cephalosporins, and carbapenems efficiently but not aztreonam. EBR-1 antibiotic_resistance ARO:3000842 EBR-1 EBR-1 is an Ambler class B beta-lactamase found in Empedobacter brevis and is known to mediate the hydrolysis of penicillins, cephalosporins, and carbapenems efficiently but not aztreonam. PMID:12234848 EBR-1 MUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus. MUS-1 antibiotic_resistance ARO:3000843 MUS-1 MUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus. PMID:12384365 MUS-1 TUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus. TUS-1 antibiotic_resistance ARO:3000844 TUS-1 TUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus. PMID:12384365 TUS-1 GIM-1 is an integron-encoded B1 beta-lactamase found in Pseudomonas aeruginosa. GIM-1 antibiotic_resistance ARO:3000845 GIM-1 GIM-1 is an integron-encoded B1 beta-lactamase found in Pseudomonas aeruginosa. PMID:15561840 GIM-1 SIM-1 is an integron-encoded Ambler class B beta-lactamase isolated from Acinetobacter baumannii. SIM-1 antibiotic_resistance ARO:3000846 SIM-1 SIM-1 is an integron-encoded Ambler class B beta-lactamase isolated from Acinetobacter baumannii. PMID:16251286 SIM-1 KHM-1 is a plasmid-mediated metallo-beta-lactamase found in Citrobacter freundii that confers resistance to all broad-spectrum beta-lactams, execpt for monobactams. KHM-1 antibiotic_resistance ARO:3000847 KHM-1 KHM-1 is a plasmid-mediated metallo-beta-lactamase found in Citrobacter freundii that confers resistance to all broad-spectrum beta-lactams, execpt for monobactams. PMID:18765691 KHM-1 Dutch imipenemase or DIM-1 is an integron-encoded metallo-beta-lactamase from Pseudomonas stutzeri. DIM-1 antibiotic_resistance ARO:3000848 DIM-1 Dutch imipenemase or DIM-1 is an integron-encoded metallo-beta-lactamase from Pseudomonas stutzeri. PMID:20308383 DIM-1 SFH-1 confers resistance to carbapenems in Serratia fonticola. SFH-1 antibiotic_resistance ARO:3000849 SFH-1 SFH-1 confers resistance to carbapenems in Serratia fonticola. PMID:12821491 SFH-1 GOB-1 confers resistance to cephalosporins in Elizabethkingia (Chryseobacterium) meningoseptica. GOB-1 antibiotic_resistance ARO:3000850 GOB-1 GOB-1 confers resistance to cephalosporins in Elizabethkingia (Chryseobacterium) meningoseptica. PMID:10858348 GOB-1 THIN-B, isolated from Janthinobacterium lividum, hydrolyzes a broad spectrum of beta-lactams including penicillins, cephalosporins, and carbapenems. THIN-B antibiotic_resistance ARO:3000851 THIN-B THIN-B, isolated from Janthinobacterium lividum, hydrolyzes a broad spectrum of beta-lactams including penicillins, cephalosporins, and carbapenems. PMID:15561856 THIN-B AIM-1 is an Ambler class B beta-lactamase that hydrolyzes most beta-lactams except aztreonam and ceftazidime. It was isolated from Pseudomonas aeruginosa and was the first subclass B3 mobile-elements encoded beta-lactamase discovered. AIM-1 antibiotic_resistance ARO:3000853 AIM-1 AIM-1 is an Ambler class B beta-lactamase that hydrolyzes most beta-lactams except aztreonam and ceftazidime. It was isolated from Pseudomonas aeruginosa and was the first subclass B3 mobile-elements encoded beta-lactamase discovered. PMID:22985886 AIM-1 SMB-1 can hydrolyze a variety of beta-lactams, including penicillins, cephalosporins, and carbapenems. It was identified in Serratia marcescens. SMB-1 antibiotic_resistance ARO:3000854 SMB-1 SMB-1 can hydrolyze a variety of beta-lactams, including penicillins, cephalosporins, and carbapenems. It was identified in Serratia marcescens. PMID:22442240 SMB-1 CAU-1 is a B3 metallo-beta-lactamase that is encoded by the Caulobacter crescentus chromosome. CAU-1 antibiotic_resistance ARO:3000855 CAU-1 CAU-1 is a B3 metallo-beta-lactamase that is encoded by the Caulobacter crescentus chromosome. PMID:12019096 CAU-1 BJP-1 is a subclass B3 ortholog found in Bradyrhizobium japonicum that hydrolyzes most beta-lactams except aztreonam, ticarcillin, and temocillin. BJP-1 antibiotic_resistance ARO:3000856 BJP-1 BJP-1 is a subclass B3 ortholog found in Bradyrhizobium japonicum that hydrolyzes most beta-lactams except aztreonam, ticarcillin, and temocillin. PMID:16723554 BJP-1 Methyltransferases that modify the 16S rRNA of the 30S subunit of bacterial ribosomes, conferring resistance to drugs that target 16S rRNA. antibiotic_resistance ARO:3000857 16S ribosomal RNA methyltransferase Methyltransferases that modify the 16S rRNA of the 30S subunit of bacterial ribosomes, conferring resistance to drugs that target 16S rRNA. PMID:14667745 PMID:21177880 PMID:22547620 ArmA is a 16S rRNA methyltransferase that targets mature or nearly mature 30S subunits. It transfers a methyl group from S-adenosyl-L-methionine to N7-G1405 of the 16S rRNA, an aminoglycoside binding site. PDB:3FZG armA antibiotic_resistance ARO:3000858 armA ArmA is a 16S rRNA methyltransferase that targets mature or nearly mature 30S subunits. It transfers a methyl group from S-adenosyl-L-methionine to N7-G1405 of the 16S rRNA, an aminoglycoside binding site. PMID:19303884 PMID:20926221 PMID:21177880 PMID:27885285 armA RmtA is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. rmtA antibiotic_resistance ARO:3000859 rmtA RmtA is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. PMID:14667745 rmtA RmtB is a 16S rRNA methyltransferase that targets mature or nearly mature 30S subunits. It transfers a methyl group from S-adenosyl-L-methionine to N7-G1405 of the 16S rRNA, an aminoglycoside binding site. PDB:3FRH rmtB antibiotic_resistance ARO:3000860 rmtB RmtB is a 16S rRNA methyltransferase that targets mature or nearly mature 30S subunits. It transfers a methyl group from S-adenosyl-L-methionine to N7-G1405 of the 16S rRNA, an aminoglycoside binding site. PMID:19303884 PMID:20614151 rmtB RmtC is a rRNA methyltransferase found in Proteus mirabilis with high level resistance to similar to aminoglycosides, with the exception of non-4,6-disubstituted deoxystreptamines (streptomycin and neomycin). It has also been isolated in Salmonella enterica ser. Virchow. It is hypothesized to methylate G1405, like related methyltransferases RmtA, RmtB, and ArmA. rmtC antibiotic_resistance ARO:3000861 rmtC RmtC is a rRNA methyltransferase found in Proteus mirabilis with high level resistance to similar to aminoglycosides, with the exception of non-4,6-disubstituted deoxystreptamines (streptomycin and neomycin). It has also been isolated in Salmonella enterica ser. Virchow. It is hypothesized to methylate G1405, like related methyltransferases RmtA, RmtB, and ArmA. PMID:16377684 PMID:20350396 PMID:21177880 PMID:26488937 rmtC Sgm, or sisomicin-gentamicin methyltransferase, methylates G1405 of 16S rRNA to confer resistance to various aminoglycosides. PDB:3LCV sgm antibiotic_resistance ARO:3000862 sgm Sgm, or sisomicin-gentamicin methyltransferase, methylates G1405 of 16S rRNA to confer resistance to various aminoglycosides. PMID:20194115 sgm MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. antibiotic_resistance ARO:3000863 defensin resistant mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. PMID:14769468 PMID:19915718 PMID:20498310 Point mutations in DNA gyrase subunit B (gyrB) observed in Mycobacterium tuberculosis can result in resistance to fluoroquinolones. antibiotic_resistance ARO:3000864 fluoroquinolone resistant gyrB Point mutations in DNA gyrase subunit B (gyrB) observed in Mycobacterium tuberculosis can result in resistance to fluoroquinolones. PMID:22279180 OleD is a glycotransferase found in Streptomyces antibioticus, a natural producer of oleandomycin. OleD can glycosylate a wide range of macrolides. Unlike oleI, oleD is not found in the oleandomycin biosynthetic cluster. PDB:2IYF oleD antibiotic_resistance ARO:3000865 oleD OleD is a glycotransferase found in Streptomyces antibioticus, a natural producer of oleandomycin. OleD can glycosylate a wide range of macrolides. Unlike oleI, oleD is not found in the oleandomycin biosynthetic cluster. PMID:10766792 PMID:17376874 PMID:8244027 oleD OleI is a glycosyltransferase found in Streptomyces antibioticus, specifically the oleandomycin biosynthetic cluster. OleI glycosylates oleandomycin to confer self-resistance. PDB:2IYA oleI antibiotic_resistance ARO:3000866 oleI OleI is a glycosyltransferase found in Streptomyces antibioticus, specifically the oleandomycin biosynthetic cluster. OleI glycosylates oleandomycin to confer self-resistance. PMID:17376874 oleI Oleandomycin is a 14-membered macrolide produced by Streptomyces antibioticus. It is ssimilar to erythromycin, and contains a desosamine amino sugar and an oleandrose sugar. It targets the 50S ribosomal subunit to prevent protein synthesis. pubchem.compound:72493 Amimycin Matromycin antibiotic_resistance ARO:3000867 oleandomycin AcetylCoA dependent acetyltransferase that acetylate streptothricins such as nourseothricin at position 16 (beta position of beta-lysine). antibiotic_resistance ARO:3000869 streptothricin acetyltransferase (SAT) AcetylCoA dependent acetyltransferase that acetylate streptothricins such as nourseothricin at position 16 (beta position of beta-lysine). PMID:3624064 PMID:8394835 Triclosan is a common antibacterial agent added to many consumer products as a biocide. It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI). pubchem.compound:5564 antibiotic_resistance ARO:3000870 triclosan Triclosan is a common antibacterial agent added to many consumer products as a biocide. It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI). PMID:10196195 PMID:19768684 Antibiotics can target bacteria-specific fatty acid biosynthesis enzymes. antibiotic_resistance ARO:3000871 fatty acid synthesis enzyme targeted by antibiotic Antibiotics can target bacteria-specific fatty acid biosynthesis enzymes. PMID:14736233 Enoyl-acyl carrier reductases catalyze the final enoyl reduction step in bacterial type II fatty acid elongation. Triclosan antibiotics block enoyl reduction and therefore fatty acid synthesis, functioning as a broad spectrum biocide and antibiotic. antibiotic_resistance ARO:3000872 antibiotic sensitive enoyl-acyl carrier reductase Enoyl-acyl carrier reductases catalyze the final enoyl reduction step in bacterial type II fatty acid elongation. Triclosan antibiotics block enoyl reduction and therefore fatty acid synthesis, functioning as a broad spectrum biocide and antibiotic. PMID:14736233 TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. RTEM-1 TEM-1 TEM-1B antibiotic_resistance ARO:3000873 TEM-1 TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. PMID:20412308 PMID:33416461 PMID:358200 PMID:5326330 TEM-1 TEM-2 is a broad-spectrum beta-lactamase. TEM-2 antibiotic_resistance ARO:3000874 TEM-2 TEM-2 is a broad-spectrum beta-lactamase. PMID:1107329 PMID:358199 TEM-2 TEM-3 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. CTX-1 TEM-14 TEM-3 antibiotic_resistance ARO:3000875 TEM-3 TEM-3 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:2550326 PMID:3316146 TEM-3 TEM-4 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-4 antibiotic_resistance ARO:3000876 TEM-4 TEM-4 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2550326 PMID:2692515 TEM-4 TEM-5 is an extended-spectrum beta-lactamase that has been found in clinical isolates. CAZ-1 TEM-5 antibiotic_resistance ARO:3000877 TEM-5 TEM-5 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2550326 PMID:3293523 TEM-5 TEM-6 is an extended-spectrum beta-lactamase found in E. coli. TEM-6 antibiotic_resistance ARO:3000878 TEM-6 TEM-6 is an extended-spectrum beta-lactamase found in E. coli. PMID:3312022 TEM-6 TEM-7 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-7 antibiotic_resistance ARO:3000879 TEM-7 TEM-7 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2506109 PMID:3055178 TEM-7 TEM-8 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. CAZ-2 TEM-8 antibiotic_resistance ARO:3000880 TEM-8 TEM-8 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:1416873 PMID:2558614 PMID:9925535 TEM-8 TEM-9 is an extended-spectrum beta-lactamase that has been found in clinical isolates. RHH-1 TEM-9 antibiotic_resistance ARO:3000881 TEM-9 TEM-9 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:3312022 PMID:3326875 TEM-9 TEM-10 is an extended-spectrum beta-lactamase round in Morganella morganii. MGH-1 TEM-10 TEM-23 TEM-E3 antibiotic_resistance ARO:3000882 TEM-10 TEM-10 is an extended-spectrum beta-lactamase round in Morganella morganii. PMID:2684007 PMID:8109951 PMID:9925535 TEM-10 TEM-11 is an extended-spectrum beta-lactamase found in Proteus mirabilis. CAZ-lo TEM-11 antibiotic_resistance ARO:3000883 TEM-11 TEM-11 is an extended-spectrum beta-lactamase found in Proteus mirabilis. PMID:2665644 PMID:9925535 TEM-11 TEM-12 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. CAZ-3 TEM-12 TEM-26b TEM-E2 YOU-2 antibiotic_resistance ARO:3000884 TEM-12 TEM-12 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. PMID:2197339 PMID:7840586 PMID:9925535 TEM-12 TEM-13 is a broad-spectrum beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3000885 TEM-13 TEM-13 is a broad-spectrum beta-lactamase that has been found in clinical isolates. PMID:9925535 TEM-15 is an extended-spectrum beta-lactamase that has been found in Haemophilus parainfluenzae. TEM-15 antibiotic_resistance ARO:3000886 TEM-15 TEM-15 is an extended-spectrum beta-lactamase that has been found in Haemophilus parainfluenzae. PMID:10681352 PMID:9925535 TEM-15 TEM-16 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. CAZ-7 TEM-16 antibiotic_resistance ARO:3000887 TEM-16 TEM-16 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:1416873 PMID:3055178 TEM-16 TEM-17 is an extended-spectrum beta-lactamase found in Capnocytophaga ochracea. TEM-17 antibiotic_resistance ARO:3000888 TEM-17 TEM-17 is an extended-spectrum beta-lactamase found in Capnocytophaga ochracea. PMID:10681352 TEM-17 TEM-18 is an extended-spectrum beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3000889 TEM-18 TEM-18 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2558614 TEM-19 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-19 antibiotic_resistance ARO:3000890 TEM-19 TEM-19 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2073111 TEM-19 TEM-20 is an extended-spectrum beta-lactamase found in several species of Gram-negative bacteria. TEM-20 antibiotic_resistance ARO:3000891 TEM-20 TEM-20 is an extended-spectrum beta-lactamase found in several species of Gram-negative bacteria. PMID:10103213 PMID:2184088 PMID:8586268 TEM-20 TEM-21 is an extended-spectrum beta-lactamase found in many species of Gram-negative bacteria. TEM-21 antibiotic_resistance ARO:3000892 TEM-21 TEM-21 is an extended-spectrum beta-lactamase found in many species of Gram-negative bacteria. PMID:10103213 PMID:2184088 PMID:8586268 PMID:9687421 TEM-21 TEM-22 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-22 antibiotic_resistance ARO:3000893 TEM-22 TEM-22 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:10103213 PMID:8239625 TEM-22 TEM-24 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. CAZ-6 TEM-24 antibiotic_resistance ARO:3000894 TEM-24 TEM-24 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:1416873 PMID:2558614 PMID:9925535 TEM-24 TEM-25 is an extended-spectrum beta-lactamase that has been found in clinical isolates. CTX-2 antibiotic_resistance ARO:3000895 TEM-25 TEM-25 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:1929316 PMID:7840586 TEM-26 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-26 YOU-1 antibiotic_resistance ARO:3000896 TEM-26 TEM-26 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:1416892 TEM-26 TEM-27 is an extended-spectrum beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3000897 TEM-27 TEM-27 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:7726515 TEM-28 is an extended-spectrum beta-lactamase found in E. coli. TEM-28 antibiotic_resistance ARO:3000898 TEM-28 TEM-28 is an extended-spectrum beta-lactamase found in E. coli. PMID:8787920 TEM-28 TEM-29 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-29 antibiotic_resistance ARO:3000899 TEM-29 TEM-29 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:8586268 TEM-29 TEM-30 is an inhibitor-resistant beta-lactamase found in E. coli. Confers resistance to amoxycilllin-clavulanic acid, ticarcillin-clavulanic acid, kanamycin, neomycin, and intermediate resistance to mezlocillin and piperacillin. E-GUER IRT-2 TEM-30 TRI-2 antibiotic_resistance ARO:3000900 TEM-30 TEM-30 is an inhibitor-resistant beta-lactamase found in E. coli. Confers resistance to amoxycilllin-clavulanic acid, ticarcillin-clavulanic acid, kanamycin, neomycin, and intermediate resistance to mezlocillin and piperacillin. PMID:1490918 PMID:33416461 PMID:8056297 TEM-30 TEM-31 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. E-SAL IRT-1 TEM-31 TRI-1 antibiotic_resistance ARO:3000901 TEM-31 TEM-31 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:1490918 PMID:8056297 TEM-31 TEM-32 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-3 TEM-32 antibiotic_resistance ARO:3000902 TEM-32 TEM-32 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:8257123 TEM-32 TEM-33 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-5 TEM-33 antibiotic_resistance ARO:3000903 TEM-33 TEM-33 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:8067742 PMID:9925535 TEM-33 TEM-34 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-6 TEM-34 TEM-97 antibiotic_resistance ARO:3000904 TEM-34 TEM-34 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:8067742 TEM-34 TEM-35 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-4 TEM-35 antibiotic_resistance ARO:3000905 TEM-35 TEM-35 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:25779568 PMID:8067742 TEM-35 TEM-36 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-7 TEM-36 antibiotic_resistance ARO:3000906 TEM-36 TEM-36 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:28369408 PMID:8067742 TEM-36 TEM-37 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-8 TEM-37 antibiotic_resistance ARO:3000907 TEM-37 TEM-37 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:26809117 PMID:7726509 TEM-37 TEM-38 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-9 antibiotic_resistance ARO:3000908 TEM-38 TEM-38 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:7726509 TEM-39 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-10 TEM-39 antibiotic_resistance ARO:3000909 TEM-39 TEM-39 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:7726509 TEM-39 TEM-40 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-11 IRT-167 TEM-40 antibiotic_resistance ARO:3000910 TEM-40 TEM-40 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:8585729 TEM-40 TEM-42 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-42 antibiotic_resistance ARO:3000911 TEM-42 TEM-42 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:8913451 TEM-42 TEM-43 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-43 antibiotic_resistance ARO:3000912 TEM-43 TEM-43 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:9661002 TEM-43 TEM-44 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT2-2 IT-13 antibiotic_resistance ARO:3000913 TEM-44 TEM-44 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:8877532 TEM-45 is an inhibitor-resistant beta-lactamase found in E. coli. IRT-14 TEM-45 antibiotic_resistance ARO:3000914 TEM-45 TEM-45 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:9021194 TEM-45 TEM-46 is an extended-spectrum beta-lactamase that has been found in clinical isolates. CAZ-9 antibiotic_resistance ARO:3000915 TEM-46 TEM-46 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:9056022 TEM-47 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-47 antibiotic_resistance ARO:3000916 TEM-47 TEM-47 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:9517925 TEM-47 TEM-48 is an extended-spectrum beta-lactamase found Klebsiella pneumoniae. TEM-48 antibiotic_resistance ARO:3000917 TEM-48 TEM-48 is an extended-spectrum beta-lactamase found Klebsiella pneumoniae. PMID:9517925 TEM-48 TEM-49 extended-spectrum beta-lactamase found in E. coli. TEM-49 antibiotic_resistance ARO:3000918 TEM-49 TEM-49 extended-spectrum beta-lactamase found in E. coli. PMID:9517925 TEM-49 TEM-50 is an inhibitor-resistant, extended-spectrum beta-lactamase that has been found in clinical isolates. CMT-1 antibiotic_resistance ARO:3000919 TEM-50 TEM-50 is an inhibitor-resistant, extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:9174192 TEM-51 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-15 antibiotic_resistance ARO:3000920 TEM-51 TEM-51 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:9371365 TEM-52 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae and Salmonella enterica. TEM-52 antibiotic_resistance ARO:3000921 TEM-52 TEM-52 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae and Salmonella enterica. PMID:9449269 TEM-52 TEM-53 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-53 antibiotic_resistance ARO:3000922 TEM-53 TEM-53 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:9925535 TEM-53 TEM-54 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-54 antibiotic_resistance ARO:3000923 TEM-54 TEM-54 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:9925535 TEM-54 TEM-55 is a broad-spectrum beta-lactamase found in E. coli. TEM-55 antibiotic_resistance ARO:3000924 TEM-55 TEM-55 TEM-56 is an extended-spectrum beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3000925 TEM-56 TEM-56 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:10639384 TEM-57 is a broad-spectrum beta-lactamase found in E. coli. TEM-57 antibiotic_resistance ARO:3000926 TEM-57 TEM-57 is a broad-spectrum beta-lactamase found in E. coli. PMID:10543745 TEM-57 TEM-58 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3000927 TEM-58 TEM-58 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:9559800 TEM-59 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-17 TEM-59 antibiotic_resistance ARO:3000928 TEM-59 TEM-59 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:10390218 TEM-59 TEM-60 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-60 antibiotic_resistance ARO:3000929 TEM-60 TEM-60 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:9624494 TEM-60 TEM-61 is an extended-spectrum beta-lactamase that has been found in clinical isolates. CAZ-hi TEM-61 antibiotic_resistance ARO:3000930 TEM-61 TEM-61 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2665644 TEM-61 TEM-63 is an extended-spectrum beta-lactamase found in E. coli. TEM-63 TEM-64 antibiotic_resistance ARO:3000931 TEM-63 TEM-63 is an extended-spectrum beta-lactamase found in E. coli. PMID:11120950 TEM-63 TEM-65 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-16 antibiotic_resistance ARO:3000932 TEM-65 TEM-65 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:10543745 TEM-66 is an extended-spectrum beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3000933 TEM-66 TEM-66 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:10543745 TEM-67 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis. TEM-67 antibiotic_resistance ARO:3000934 TEM-67 TEM-67 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis. PMID:12499163 TEM-67 TEM-68 is an inhibitor resistant, extended-spectrum beta-lactamase found in Klebsiella pneumoniae. CMT-2 TEM-68 antibiotic_resistance ARO:3000935 TEM-68 TEM-68 is an inhibitor resistant, extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:10817699 PMID:12019125 TEM-68 TEM-70 is a beta-lactamase found in E. coli. TEM-70 antibiotic_resistance ARO:3000936 TEM-70 TEM-70 is a beta-lactamase found in E. coli. PMID:23643553 TEM-70 TEM-71 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-71 antibiotic_resistance ARO:3000937 TEM-71 TEM-71 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:12019125 TEM-71 TEM-72 is an extended-spectrum beta-lactamase found in Proteus mirabilis and Morganella morganii. TEM-72 antibiotic_resistance ARO:3000938 TEM-72 TEM-72 is an extended-spectrum beta-lactamase found in Proteus mirabilis and Morganella morganii. PMID:10952610 TEM-72 TEM-73 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-18 TEM-73 antibiotic_resistance ARO:3000939 TEM-73 TEM-73 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:10543745 TEM-73 TEM-74 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-19 antibiotic_resistance ARO:3000940 TEM-74 TEM-74 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:10543745 TEM-75 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-75 antibiotic_resistance ARO:3000941 TEM-75 TEM-75 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:10624595 TEM-75 TEM-76 is an inhibitor-resistant beta-lactamase found in E. coli. IRT-20 TEM-76 antibiotic_resistance ARO:3000942 TEM-76 TEM-76 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-76 TEM-78 is an inhibitor-resistant beta-lactamase found in E. coli. IRT-22 TEM-78 antibiotic_resistance ARO:3000944 TEM-78 TEM-78 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-78 TEM-79 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-79 antibiotic_resistance ARO:3000946 TEM-79 TEM-79 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-79 TEM-80 is an inhibitor-resistant beta-lactamase found in Enterobacter cloacae. IRT-24 TEM-80 antibiotic_resistance ARO:3000947 TEM-80 TEM-80 is an inhibitor-resistant beta-lactamase found in Enterobacter cloacae. PMID:11959543 TEM-80 TEM-81 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-81 antibiotic_resistance ARO:3000948 TEM-81 TEM-81 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-81 TEM-82 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-82 antibiotic_resistance ARO:3000949 TEM-82 TEM-82 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-82 TEM-83 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-83 antibiotic_resistance ARO:3000950 TEM-83 TEM-83 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-83 TEM-84 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-84 antibiotic_resistance ARO:3000951 TEM-84 TEM-84 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-84 TEM-85 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-85 antibiotic_resistance ARO:3000952 TEM-85 TEM-85 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15855509 TEM-85 TEM-86 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-86 antibiotic_resistance ARO:3000953 TEM-86 TEM-86 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15855509 TEM-86 TEM-87 is an extended-spectrum beta-lactamase found in Proteus mirabilis. TEM-87 antibiotic_resistance ARO:3000954 TEM-87 TEM-87 is an extended-spectrum beta-lactamase found in Proteus mirabilis. PMID:11850290 TEM-87 TEM-88 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-88 antibiotic_resistance ARO:3000955 TEM-88 TEM-88 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11709362 TEM-88 TEM-89 is an inhibitor-resistant, extended-spectrum beta-lactamase that has been found in clinical isolates. CMT-3 TEM-89 antibiotic_resistance ARO:3000956 TEM-89 TEM-89 is an inhibitor-resistant, extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:11709345 TEM-89 TEM-90 is a broad-spectrum beta-lactamase found in E. coli. TEM-90 TLE-1 antibiotic_resistance ARO:3000957 TEM-90 TEM-90 is a broad-spectrum beta-lactamase found in E. coli. PMID:11557499 TEM-90 TEM-91 is an extended-spectrum beta-lactamase found in E. coli. TEM-91 antibiotic_resistance ARO:3000958 TEM-91 TEM-91 is an extended-spectrum beta-lactamase found in E. coli. PMID:12937007 TEM-91 TEM-92 is an extended-spectrum beta-lactamase found in Proteus mirabilis. TEM-92 antibiotic_resistance ARO:3000959 TEM-92 TEM-92 is an extended-spectrum beta-lactamase found in Proteus mirabilis. PMID:11257046 TEM-92 TEM-93 is an extended-spectrum beta-lactamase found in E. coli. TEM-93 antibiotic_resistance ARO:3000960 TEM-93 TEM-93 is an extended-spectrum beta-lactamase found in E. coli. PMID:15855509 TEM-93 TEM-94 is an extended-spectrum beta-lactamase found in E. coli. TEM-94 antibiotic_resistance ARO:3000961 TEM-94 TEM-94 is an extended-spectrum beta-lactamase found in E. coli. PMID:15855509 TEM-94 TEM-95 is a broad-spectrum beta-lactamase found in E. coli. TEM-95 antibiotic_resistance ARO:3000962 TEM-95 TEM-95 is a broad-spectrum beta-lactamase found in E. coli. PMID:12234838 TEM-95 TEM-96 is a beta-lactamase found in E. coli. TEM-96 antibiotic_resistance ARO:3000963 TEM-96 TEM-96 is a beta-lactamase found in E. coli. PMID:24499167 TEM-96 TEM-101 is an extended-spectrum beta-lactamase found in E. coli. TEM-101 antibiotic_resistance ARO:3000964 TEM-101 TEM-101 is an extended-spectrum beta-lactamase found in E. coli. PMID:3055178 TEM-101 TEM-102 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-102 antibiotic_resistance ARO:3000965 TEM-102 TEM-102 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:12878521 TEM-102 TEM-103 is an inhibitor-resistant beta-lactamase that has been found in E. coli. IRT-28 TEM-103 antibiotic_resistance ARO:3000966 TEM-103 TEM-103 is an inhibitor-resistant beta-lactamase that has been found in E. coli. PMID:12384377 TEM-103 TEM-104 is a beta-lactamase found in Klebsiella pneumoniae. TEM-104 antibiotic_resistance ARO:3000967 TEM-104 TEM-104 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16533535 PMID:27598630 TEM-104 TEM-105 is a beta-lactamase found in E. coli. TEM-105 antibiotic_resistance ARO:3000968 TEM-105 TEM-105 is a beta-lactamase found in E. coli. PMID:16533535 TEM-105 TEM-106 is an extended-spectrum beta-lactamase found in E. coli. TEM-106 antibiotic_resistance ARO:3000969 TEM-106 TEM-106 is an extended-spectrum beta-lactamase found in E. coli. PMID:11959586 TEM-106 TEM-107 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-107 antibiotic_resistance ARO:3000970 TEM-107 TEM-107 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11959586 TEM-107 TEM-108 is a beta-lactamase that has been found in clinical isolates. TEM-108 antibiotic_resistance ARO:3000971 TEM-108 TEM-108 is a beta-lactamase that has been found in clinical isolates. PMID:15297528 TEM-108 TEM-109 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. CMT-5 TEM-109 antibiotic_resistance ARO:3000972 TEM-109 TEM-109 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. PMID:16251281 TEM-109 TEM-110 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-110 antibiotic_resistance ARO:3000973 TEM-110 TEM-110 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:18292096 TEM-110 TEM-111 is a beta-lactamase found in E. coli and P. mirabilis. TEM-111 antibiotic_resistance ARO:3000974 TEM-111 TEM-111 is a beta-lactamase found in E. coli and P. mirabilis. PMID:22450979 TEM-111 TEM-112 is an extended-spectrum beta-lactamase found in E. coli. TEM-112 antibiotic_resistance ARO:3000975 TEM-112 TEM-112 is an extended-spectrum beta-lactamase found in E. coli. PMID:15282240 TEM-112 TEM-113 is an extended-spectrum beta-lactamase found in Proteus mirabilis. TEM-113 antibiotic_resistance ARO:3000976 TEM-113 TEM-113 is an extended-spectrum beta-lactamase found in Proteus mirabilis. PMID:15282240 TEM-113 TEM-114 is an extended-spectrum beta-lactamase found in Klebsiella aerogenes. TEM-114 antibiotic_resistance ARO:3000977 TEM-114 TEM-114 is an extended-spectrum beta-lactamase found in Klebsiella aerogenes. PMID:15282240 TEM-114 TEM-115 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-115 antibiotic_resistance ARO:3000978 TEM-115 TEM-115 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15047521 TEM-115 TEM-116 is a broad-spectrum beta-lactamase found in many species of bacteria. TEM-116 antibiotic_resistance ARO:3000979 TEM-116 TEM-116 is a broad-spectrum beta-lactamase found in many species of bacteria. PMID:15243036 TEM-116 TEM-117 is a beta-lactamase that has been found in clinical isolates. TEM-117 antibiotic_resistance ARO:3000980 TEM-117 TEM-117 TEM-118 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-118 TEM-HM antibiotic_resistance ARO:3000981 TEM-118 TEM-118 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:12354869 TEM-118 TEM-120 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. TEM-120 antibiotic_resistance ARO:3000982 TEM-120 TEM-120 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. PMID:15047521 TEM-120 TEM-121 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli and Klebsiella aerogenes. CMT-4 TEM-121 antibiotic_resistance ARO:3000983 TEM-121 TEM-121 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli and Klebsiella aerogenes. PMID:15561821 TEM-121 TEM-122 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-122 antibiotic_resistance ARO:3000984 TEM-122 TEM-122 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:15105100 TEM-122 TEM-123 is an extended-spectrum beta-lactamase found in Proteus mirabilis. TEM-123 antibiotic_resistance ARO:3000985 TEM-123 TEM-123 TEM-124 is an extended-spectrum beta-lactamase found in Morganella morganii. TEM-124 antibiotic_resistance ARO:3000986 TEM-124 TEM-124 TEM-125 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. TEM-125 antibiotic_resistance ARO:3000987 TEM-125 TEM-125 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. PMID:16801418 TEM-125 TEM-126 is an extended-spectrum beta-lactamase found in E. coli. TEM-126 antibiotic_resistance ARO:3000988 TEM-126 TEM-126 is an extended-spectrum beta-lactamase found in E. coli. PMID:15282240 TEM-126 TEM-127 is a broad-spectrum beta-lactamase found in E. coli. TEM-127 antibiotic_resistance ARO:3000989 TEM-127 TEM-127 is a broad-spectrum beta-lactamase found in E. coli. PMID:15650379 TEM-127 TEM-128 is a broad-spectrum beta-lactamase found in E. coli. TEM-128 antibiotic_resistance ARO:3000990 TEM-128 TEM-128 is a broad-spectrum beta-lactamase found in E. coli. PMID:15650379 TEM-128 TEM-129 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. TEM-129 antibiotic_resistance ARO:3000993 TEM-129 TEM-129 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. PMID:15472005 TEM-129 TEM-130 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-130 antibiotic_resistance ARO:3000994 TEM-130 TEM-130 TEM-131 is an extended-spectrum beta-lactamase found in Salmonella enterica. TEM-131 antibiotic_resistance ARO:3000995 TEM-131 TEM-131 is an extended-spectrum beta-lactamase found in Salmonella enterica. PMID:15504851 TEM-131 TEM-132 is an extended-spectrum beta-lactamase found in E. coli and Klebsiella pneumoniae. TEM-132 antibiotic_resistance ARO:3000996 TEM-132 TEM-132 is an extended-spectrum beta-lactamase found in E. coli and Klebsiella pneumoniae. PMID:15980402 TEM-132 TEM-133 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-133 antibiotic_resistance ARO:3000997 TEM-133 TEM-133 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15855544 TEM-133 TEM-134 is an extended-spectrum beta-lactamase found in Citrobacter koseri. TEM-134 antibiotic_resistance ARO:3000998 TEM-134 TEM-134 is an extended-spectrum beta-lactamase found in Citrobacter koseri. PMID:15793140 TEM-134 TEM-135 is a broad-spectrum beta-lactamase found in Salmonella enterica. TEM-135 antibiotic_resistance ARO:3000999 TEM-135 TEM-135 is a broad-spectrum beta-lactamase found in Salmonella enterica. PMID:15731203 PMID:31202926 TEM-135 TEM-136 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-136 antibiotic_resistance ARO:3001000 TEM-136 TEM-136 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:16531430 TEM-136 TEM-137 is an extended-spectrum beta-lactamase found in Shigella sonnei. TEM-137 antibiotic_resistance ARO:3001001 TEM-137 TEM-137 is an extended-spectrum beta-lactamase found in Shigella sonnei. PMID:17561568 TEM-137 TEM-138 is an extended-spectrum beta-lactamase found in Salmonella enterica. TEM-138 antibiotic_resistance ARO:3001002 TEM-138 TEM-138 is an extended-spectrum beta-lactamase found in Salmonella enterica. PMID:16940125 TEM-138 TEM-139 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-139 antibiotic_resistance ARO:3001003 TEM-139 TEM-139 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:17382521 TEM-139 TEM-141 is a broad-spectrum beta-lactamase found in Enterobacter cloacae. TEM-141 antibiotic_resistance ARO:3001004 TEM-141 TEM-141 is a broad-spectrum beta-lactamase found in Enterobacter cloacae. PMID:17881870 TEM-141 TEM-142 is an beta-lactamase found in E. coli. TEM-142 antibiotic_resistance ARO:3001005 TEM-142 TEM-142 TEM-143 is an extended-spectrum beta-lactamase found in E. coli. TEM-143 antibiotic_resistance ARO:3001006 TEM-143 TEM-143 TEM-144 is an extended-spectrum beta-lactamase found in Salmonella enterica. TEM-144 antibiotic_resistance ARO:3001007 TEM-144 TEM-144 is an extended-spectrum beta-lactamase found in Salmonella enterica. PMID:16436745 TEM-144 TEM-145 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-145 antibiotic_resistance ARO:3001012 TEM-145 TEM-145 TEM-146 is a beta-lactamase found in E. coli. TEM-146 antibiotic_resistance ARO:3001013 TEM-146 TEM-146 TEM-147 is an extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. TEM-147 antibiotic_resistance ARO:3001014 TEM-147 TEM-147 TEM-148 is a TEM beta-lactamase. TEM-148 antibiotic_resistance ARO:3001015 TEM-148 TEM-148 TEM-149 is an extended-spectrum beta-lactamase found in Klebsiella aerogenes. TEM-149 antibiotic_resistance ARO:3001016 TEM-149 TEM-149 is an extended-spectrum beta-lactamase found in Klebsiella aerogenes. PMID:18160520 TEM-149 TEM-150 is a beta-lactamase found in Enterobacter spp., E. coli, and Klebsiella pneumoniae. TEM-150 antibiotic_resistance ARO:3001017 TEM-150 TEM-150 TEM-151 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. TEM-151 antibiotic_resistance ARO:3001018 TEM-151 TEM-151 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. PMID:17220412 TEM-151 TEM-152 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. TEM-152 antibiotic_resistance ARO:3001019 TEM-152 TEM-152 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. PMID:17220412 TEM-152 TEM-154 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase. TEM-154 antibiotic_resistance ARO:3001020 TEM-154 TEM-154 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase. PMID:17913717 TEM-154 TEM-155 is an extended-spectrum beta-lactamase. TEM-155 antibiotic_resistance ARO:3001021 TEM-155 TEM-155 is an extended-spectrum beta-lactamase. PMID:19075050 TEM-155 TEM-156 is a TEM beta-lactamase. TEM-156 antibiotic_resistance ARO:3001022 TEM-156 TEM-156 TEM-157 is an extended-spectrum beta-lactamase found in Enterobacter cloacae. TEM-157 antibiotic_resistance ARO:3001023 TEM-157 TEM-157 is an extended-spectrum beta-lactamase found in Enterobacter cloacae. PMID:18653970 TEM-157 TEM-158 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. CMT-9 TEM-158 antibiotic_resistance ARO:3001024 TEM-158 TEM-158 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. PMID:17709463 TEM-158 TEM-159 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis. TEM-159 antibiotic_resistance ARO:3001025 TEM-159 TEM-159 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis. PMID:18292096 TEM-159 TEM-160 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis. TEM-160 antibiotic_resistance ARO:3001026 TEM-160 TEM-160 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis. PMID:18292096 TEM-160 TEM-161 is a beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3001027 TEM-161 TEM-162 is a beta-lactamase found in Acinetobacter haemolyticus. TEM-162 antibiotic_resistance ARO:3001028 TEM-162 TEM-162 TEM-163 is an inhibitor resistant beta-lactamase found in E. coli. TEM-163 antibiotic_resistance ARO:3001029 TEM-163 TEM-163 TEM-164 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-164 antibiotic_resistance ARO:3001030 TEM-164 TEM-164 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19728777 TEM-164 TEM-165 is a beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3001031 TEM-165 TEM-165 is a beta-lactamase that has been found in clinical isolates. PMID:21860889 TEM-166 is a beta-lactamase found in E. coli. TEM-166 antibiotic_resistance ARO:3001032 TEM-166 TEM-166 TEM-167 is an extended-spectrum beta-lactamase found in E. coli. TEM-167 antibiotic_resistance ARO:3001033 TEM-167 TEM-167 TEM-168 is an extended-spectrum beta-lactamase. TEM-168 antibiotic_resistance ARO:3001034 TEM-168 TEM-168 is an extended-spectrum beta-lactamase. PMID:19687235 TEM-168 TEM-169 is an extended spectrum beta-lactamase. TEM-169 antibiotic_resistance ARO:3001035 TEM-169 TEM-169 is an extended spectrum beta-lactamase. PMID:19785534 TEM-169 TEM-170 is a beta-lactamase. antibiotic_resistance ARO:3001036 TEM-170 TEM-170 is a beta-lactamase. PMID:21903826 TEM-171 is a beta-lactamase. TEM-171 antibiotic_resistance ARO:3001037 TEM-171 TEM-171 is a beta-lactamase. PMID:21903826 TEM-171 TEM-172 is a beta-lactamase. antibiotic_resistance ARO:3001038 TEM-172 TEM-172 is a beta-lactamase. PMID:21903826 TEM-173 is a beta-lactamase. antibiotic_resistance ARO:3001039 TEM-173 TEM-173 is a beta-lactamase. PMID:21903826 TEM-174 is a beta-lactamase. antibiotic_resistance ARO:3001040 TEM-174 TEM-174 is a beta-lactamase. PMID:21903826 TEM-176 is a beta-lactamase. TEM-176 antibiotic_resistance ARO:3001041 TEM-176 TEM-176 is a beta-lactamase. PMID:23643553 TEM-176 TEM-177 is an extended-spectrum beta-lactamase. TEM-177 antibiotic_resistance ARO:3001042 TEM-177 TEM-177 is an extended-spectrum beta-lactamase. PMID:23210906 TEM-177 TEM-178 is an inhibitor-resistant, extended-spectrum beta-lactamase. TEM-178 antibiotic_resistance ARO:3001043 TEM-178 TEM-178 is an inhibitor-resistant, extended-spectrum beta-lactamase. PMID:9371336 TEM-178 TEM-181 is a beta-lactamase. TEM-181 antibiotic_resistance ARO:3001044 TEM-181 TEM-181 is a beta-lactamase. PMID:21947397 TEM-181 TEM-183 is a broad-spectrum beta-lactamase. TEM-183 antibiotic_resistance ARO:3001045 TEM-183 TEM-183 TEM-186 is a beta-lactamase. TEM-186 antibiotic_resistance ARO:3001046 TEM-186 TEM-186 is a beta-lactamase. PMID:22397509 TEM-186 TEM-187 is an extended-spectrum beta-lactamase found in P. mirabilis. TEM-187 antibiotic_resistance ARO:3001047 TEM-187 TEM-187 is an extended-spectrum beta-lactamase found in P. mirabilis. PMID:23478954 TEM-187 TEM-188 is an extended-spectrum beta-lactamase. TEM-188 antibiotic_resistance ARO:3001048 TEM-188 TEM-188 is an extended-spectrum beta-lactamase. PMID:22871227 TEM-188 TEM-189 is a beta-lactamase. TEM-189 antibiotic_resistance ARO:3001049 TEM-189 TEM-189 TEM-190 is a beta-lactamase. TEM-190 antibiotic_resistance ARO:3001050 TEM-190 TEM-190 TEM-191 is a beta-lactamase. TEM-191 antibiotic_resistance ARO:3001051 TEM-191 TEM-191 is a beta-lactamase. PMID:22718774 TEM-191 TEM-192 is a beta-lactamase. TEM-192 antibiotic_resistance ARO:3001052 TEM-192 TEM-192 is a beta-lactamase. PMID:22718774 TEM-192 TEM-193 is a beta-lactamase. TEM-193 antibiotic_resistance ARO:3001053 TEM-193 TEM-193 TEM-194 is a beta-lactamase. TEM-194 antibiotic_resistance ARO:3001054 TEM-194 TEM-194 TEM-195 is a beta-lactamase. TEM-195 antibiotic_resistance ARO:3001055 TEM-195 TEM-195 is a beta-lactamase. PMID:24499167 TEM-195 TEM-197 is an extended-spectrum beta-lactamase. TEM-197 antibiotic_resistance ARO:3001056 TEM-197 TEM-197 TEM-198 is a beta-lactamase. TEM-198 antibiotic_resistance ARO:3001057 TEM-198 TEM-198 TEM-199 is a beta-lactamase. TEM-199 antibiotic_resistance ARO:3001058 TEM-199 TEM-199 SHV-1 is a broad-spectrum beta-lactamase found in Klebsiella spp., as well as Acinetobacter spp., E. coli., Raoultella terrigena, and Yersinia pestis. PIT-2 SHV-1 antibiotic_resistance ARO:3001059 SHV-1 SHV-1 is a broad-spectrum beta-lactamase found in Klebsiella spp., as well as Acinetobacter spp., E. coli., Raoultella terrigena, and Yersinia pestis. PMID:10582889 PMID:378931 SHV-1 SHV-2 is an extended-spectrum beta-lactamase found in E. coli., Klebsiella pneumoniae, and Shigella flexneri. SHV-2 antibiotic_resistance ARO:3001060 SHV-2 SHV-2 is an extended-spectrum beta-lactamase found in E. coli., Klebsiella pneumoniae, and Shigella flexneri. PMID:10582889 PMID:2033379 SHV-2 SHV-2A is an extended-spectrum beta-lactamase found in Enterobacter cloacae, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enterica. SHV-2A antibiotic_resistance ARO:3001061 SHV-2A SHV-2A is an extended-spectrum beta-lactamase found in Enterobacter cloacae, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enterica. PMID:10223953 SHV-2A SHV-3 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-3 antibiotic_resistance ARO:3001062 SHV-3 SHV-3 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:2033379 PMID:2694951 SHV-3 SHV-4 is an extended-spectrum beta-lactamase that has been found in clinical isolates. CAZ-5 SHV-4 antibiotic_resistance ARO:3001063 SHV-4 SHV-4 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2694955 SHV-4 SHV-5 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii, Enterobacter cloacae, E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enterica. CAZ-4 SHV-5 antibiotic_resistance ARO:3001064 SHV-5 SHV-5 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii, Enterobacter cloacae, E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enterica. PMID:2088203 SHV-5 SHV-6 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-6 antibiotic_resistance ARO:3001065 SHV-6 SHV-6 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:9228783 SHV-6 SHV-7 is an extended-spectrum beta-lactamase found in E. coli. SHV-7 antibiotic_resistance ARO:3001066 SHV-7 SHV-7 is an extended-spectrum beta-lactamase found in E. coli. PMID:7785992 SHV-7 SHV-8 is an extended-spectrum beta-lactamase found in E. coli. SHV-8 antibiotic_resistance ARO:3001067 SHV-8 SHV-8 is an extended-spectrum beta-lactamase found in E. coli. PMID:9056008 SHV-8 SHV-9 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-5a SHV-9 antibiotic_resistance ARO:3001068 SHV-9 SHV-9 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:8674992 PMID:9087500 SHV-9 SHV-10 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3001069 SHV-10 SHV-10 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:9087500 SHV-11 is a broad-spectrum beta-lactamase found in E. coli, Klebsiella pneumoniae, Proteus mirabilis, and Shigella dysenteriae. SHV-1-2a SHV-11 antibiotic_resistance ARO:3001070 SHV-11 SHV-11 is a broad-spectrum beta-lactamase found in E. coli, Klebsiella pneumoniae, Proteus mirabilis, and Shigella dysenteriae. PMID:9145849 SHV-11 SHV-12 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii. SHV-12 SHV-5-2a antibiotic_resistance ARO:3001071 SHV-12 SHV-12 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii. PMID:9145849 SHV-12 SHV-13 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-13 antibiotic_resistance ARO:3001072 SHV-13 SHV-13 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:10722518 SHV-13 SHV-14 is an broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-14 antibiotic_resistance ARO:3001073 SHV-14 SHV-14 is an broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11120985 SHV-14 SHV-15 is an extended-spectrum beta-lactamase found in E. coli. SHV-15 antibiotic_resistance ARO:3001074 SHV-15 SHV-15 is an extended-spectrum beta-lactamase found in E. coli. PMID:10689171 SHV-15 SHV-16 is an extended-spectrum beta-lactamase that has been found in clinical isolates. It differs from SHV-1 by a 163DRWET167 insertion. SHV-16 antibiotic_resistance ARO:3001075 SHV-16 SHV-16 is an extended-spectrum beta-lactamase that has been found in clinical isolates. It differs from SHV-1 by a 163DRWET167 insertion. PMID:11502518 SHV-16 SHV-18 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii and Klebsiella pneumoniae. SHV-18 antibiotic_resistance ARO:3001076 SHV-18 SHV-18 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii and Klebsiella pneumoniae. PMID:10952583 SHV-18 SHV-19 is a broad-spectrum beta-lactamase that has been found in clinical isolates. SHV-19 antibiotic_resistance ARO:3001077 SHV-19 SHV-19 is a broad-spectrum beta-lactamase that has been found in clinical isolates. PMID:11120950 SHV-19 SHV-20 is a broad-spectrum beta-lactamase that has been found in clinical isolates. SHV-20 antibiotic_resistance ARO:3001078 SHV-20 SHV-20 is a broad-spectrum beta-lactamase that has been found in clinical isolates. PMID:11120950 SHV-20 SHV-21 is a broad-spectrum beta-lactamase that has been found in clinical isolates. SHV-21 antibiotic_resistance ARO:3001079 SHV-21 SHV-21 is a broad-spectrum beta-lactamase that has been found in clinical isolates. PMID:11120950 SHV-21 SHV-22 is a broad-spectrum beta-lactamase that has been found in clinical isolates. SHV-22 antibiotic_resistance ARO:3001080 SHV-22 SHV-22 is a broad-spectrum beta-lactamase that has been found in clinical isolates. PMID:11120950 SHV-22 SHV-23 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-23 antibiotic_resistance ARO:3001081 SHV-23 SHV-23 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:15081091 SHV-23 SHV-24 is an extended-spectrum beta-lactamase found in E. coli. SHV-24 antibiotic_resistance ARO:3001082 SHV-24 SHV-24 is an extended-spectrum beta-lactamase found in E. coli. PMID:10817740 SHV-24 SHV-25 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-25 antibiotic_resistance ARO:3001083 SHV-25 SHV-25 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11502506 SHV-25 SHV-26 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. SHV-26 antibiotic_resistance ARO:3001084 SHV-26 SHV-26 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. PMID:11502506 SHV-26 SHV-27 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-27 antibiotic_resistance ARO:3001085 SHV-27 SHV-27 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11266422 SHV-27 SHV-28 is a beta-lactamase found in Klebsiella pneumoniae. SHV-28 antibiotic_resistance ARO:3001086 SHV-28 SHV-28 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19172061 SHV-28 SHV-29 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-29 antibiotic_resistance ARO:3001087 SHV-29 SHV-29 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11257029 SHV-29 SHV-30 is an extended-spectrum beta-lactamase found in Enterobacter cloacae. SHV-30 antibiotic_resistance ARO:3001088 SHV-30 SHV-30 is an extended-spectrum beta-lactamase found in Enterobacter cloacae. PMID:16251316 SHV-30 SHV-31 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-31 antibiotic_resistance ARO:3001089 SHV-31 SHV-31 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:17178800 SHV-31 SHV-32 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-32 antibiotic_resistance ARO:3001090 SHV-32 SHV-32 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11557480 SHV-32 SHV-33 is an broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-33 antibiotic_resistance ARO:3001091 SHV-33 SHV-33 is an broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11557480 SHV-33 SHV-34 is an extended-spectrum beta-lactamase found in E. coli. SHV-34 antibiotic_resistance ARO:3001092 SHV-34 SHV-34 is an extended-spectrum beta-lactamase found in E. coli. PMID:14613945 SHV-34 SHV-35 is a beta-lactamase found in Klebsiella pneumoniae. SHV-35 antibiotic_resistance ARO:3001093 SHV-35 SHV-35 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15047521 SHV-35 SHV-36 is a beta-lactamase found in Klebsiella pneumoniae. SHV-36 antibiotic_resistance ARO:3001094 SHV-36 SHV-36 is a beta-lactamase found in Klebsiella pneumoniae. PMID:17913717 SHV-36 SHV-37 is a beta-lactamase found in Klebsiella pneumoniae. SHV-37 antibiotic_resistance ARO:3001095 SHV-37 SHV-37 SHV-38 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-38 antibiotic_resistance ARO:3001096 SHV-38 SHV-38 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:12543688 SHV-38 SHV-39 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-39 antibiotic_resistance ARO:3001097 SHV-39 SHV-39 SHV-40 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-40 antibiotic_resistance ARO:3001098 SHV-40 SHV-40 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15047521 SHV-40 SHV-41 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-41 antibiotic_resistance ARO:3001099 SHV-41 SHV-41 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15047521 SHV-41 SHV-42 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-42 antibiotic_resistance ARO:3001100 SHV-42 SHV-42 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15047521 SHV-42 SHV-43 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-43 antibiotic_resistance ARO:3001101 SHV-43 SHV-43 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:12543694 SHV-43 SHV-44 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-44 antibiotic_resistance ARO:3001102 SHV-44 SHV-44 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:14576109 SHV-44 SHV-45 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-45 antibiotic_resistance ARO:3001103 SHV-45 SHV-45 SHV-46 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. SHV-46 antibiotic_resistance ARO:3001104 SHV-46 SHV-46 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. PMID:14638498 SHV-46 SHV-48 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-48 antibiotic_resistance ARO:3001105 SHV-48 SHV-48 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19075050 SHV-48 SHV-49 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. SHV-49 antibiotic_resistance ARO:3001106 SHV-49 SHV-49 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. PMID:15504885 SHV-49 SHV-50 is a beta-lactamase found in Klebsiella pneumoniae. SHV-50 antibiotic_resistance ARO:3001107 SHV-50 SHV-50 SHV-51 is a beta-lactamase found in Klebsiella pneumoniae. SHV-51 antibiotic_resistance ARO:3001108 SHV-51 SHV-51 SHV-52 is a beta-lactamase that has been found in clinical isolates. SHV-52 antibiotic_resistance ARO:3001109 SHV-52 SHV-52 SHV-53 is a beta-lactamase that has been found in clinical isolates. SHV-53 antibiotic_resistance ARO:3001110 SHV-53 SHV-53 SHV-55 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-55 antibiotic_resistance ARO:3001111 SHV-55 SHV-55 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:16938422 SHV-55 SHV-56 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. SHV-56 antibiotic_resistance ARO:3001112 SHV-56 SHV-56 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. PMID:18663019 SHV-56 SHV-57 is an extended-spectrum beta-lactamase found in E. coli. SHV-57 antibiotic_resistance ARO:3001113 SHV-57 SHV-57 is an extended-spectrum beta-lactamase found in E. coli. PMID:15673739 SHV-57 SHV-59 is a beta-lactamase found in Klebsiella pneumoniae. SHV-59 antibiotic_resistance ARO:3001114 SHV-59 SHV-59 SHV-60 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-60 antibiotic_resistance ARO:3001115 SHV-60 SHV-60 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-60 SHV-61 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-61 antibiotic_resistance ARO:3001116 SHV-61 SHV-61 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-61 SHV-62 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-62 antibiotic_resistance ARO:3001117 SHV-62 SHV-62 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-62 SHV-63 is a beta-lactamase found in Klebsiella pneumoniae. SHV-63 antibiotic_resistance ARO:3001118 SHV-63 SHV-63 SHV-64 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-64 antibiotic_resistance ARO:3001119 SHV-64 SHV-64 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:17288792 SHV-64 SHV-65 is a beta-lactamase found in Klebsiella pneumoniae. SHV-65 antibiotic_resistance ARO:3001120 SHV-65 SHV-65 is a beta-lactamase found in Klebsiella pneumoniae. PMID:17288792 SHV-65 SHV-66 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-66 antibiotic_resistance ARO:3001121 SHV-66 SHV-66 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:17288792 SHV-66 SHV-67 is a beta-lactamase found in Klebsiella pneumoniae. SHV-67 antibiotic_resistance ARO:3001122 SHV-67 SHV-67 is a beta-lactamase found in Klebsiella pneumoniae. PMID:17288792 SHV-67 SHV-69 is a beta-lactamase found in Klebsiella pneumoniae. SHV-69 antibiotic_resistance ARO:3001123 SHV-69 SHV-69 is a beta-lactamase found in Klebsiella pneumoniae. PMID:17288792 SHV-69 SHV-70 is an extended-spectrum beta-lactamase found in Enterobacter cloacae. SHV-70 antibiotic_resistance ARO:3001124 SHV-70 SHV-70 is an extended-spectrum beta-lactamase found in Enterobacter cloacae. PMID:16563703 SHV-70 SHV-71 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae and Shigella. SHV-71 antibiotic_resistance ARO:3001125 SHV-71 SHV-71 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae and Shigella. PMID:19272757 SHV-71 SHV-72 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. SHV-72 antibiotic_resistance ARO:3001126 SHV-72 SHV-72 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. PMID:18316518 SHV-72 SHV-73 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-73 antibiotic_resistance ARO:3001127 SHV-73 SHV-73 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-73 SHV-74 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-74 antibiotic_resistance ARO:3001128 SHV-74 SHV-74 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-74 SHV-75 is a broad-spectrum beta-lactamase that is found in clinical isolates. SHV-75 antibiotic_resistance ARO:3001129 SHV-75 SHV-75 is a broad-spectrum beta-lactamase that is found in clinical isolates. PMID:19272757 SHV-75 SHV-76 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-76 antibiotic_resistance ARO:3001130 SHV-76 SHV-76 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-76 SHV-77 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae and E. coli. SHV-77 antibiotic_resistance ARO:3001131 SHV-77 SHV-77 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae and E. coli. PMID:19272757 SHV-77 SHV-78 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-78 antibiotic_resistance ARO:3001132 SHV-78 SHV-78 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-78 SHV-79 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-79 antibiotic_resistance ARO:3001133 SHV-79 SHV-79 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-79 SHV-80 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-80 antibiotic_resistance ARO:3001134 SHV-80 SHV-80 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-80 SHV-81 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-81 antibiotic_resistance ARO:3001135 SHV-81 SHV-81 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-81 SHV-82 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-82 antibiotic_resistance ARO:3001136 SHV-82 SHV-82 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-82 SHV-83 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-83 antibiotic_resistance ARO:3001137 SHV-83 SHV-83 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-83 SHV-84 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. SHV-84 antibiotic_resistance ARO:3001138 SHV-84 SHV-84 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:20211886 SHV-84 SHV-85 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-85 antibiotic_resistance ARO:3001139 SHV-85 SHV-85 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:18347108 SHV-85 SHV-86 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-86 antibiotic_resistance ARO:3001140 SHV-86 SHV-86 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:20566419 SHV-86 SHV-89 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-89 antibiotic_resistance ARO:3001141 SHV-89 SHV-89 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:18587684 SHV-89 SHV-90 is an extended-spectrum beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3001142 SHV-90 SHV-90 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:17913717 SHV-91 is an extended-spectrum beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3001143 SHV-91 SHV-91 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:17913717 SHV-92 is a beta-lactamase found in Klebsiella pneumoniae. SHV-92 antibiotic_resistance ARO:3001144 SHV-92 SHV-92 is a beta-lactamase found in Klebsiella pneumoniae. PMID:18029415 SHV-92 SHV-93 is a beta-lactamase found in Klebsiella pneumoniae. SHV-93 antibiotic_resistance ARO:3001145 SHV-93 SHV-93 SHV-94 is a beta-lactamase found in Klebsiella pneumoniae. SHV-94 antibiotic_resistance ARO:3001146 SHV-94 SHV-94 SHV-95 is a beta-lactamase found in Citrobacter freundii. SHV-95 antibiotic_resistance ARO:3001147 SHV-95 SHV-95 is a beta-lactamase found in Citrobacter freundii. PMID:21383920 SHV-95 SHV-96 is a beta-lactamase found in Acinetobacter baumannii. SHV-96 antibiotic_resistance ARO:3001148 SHV-96 SHV-96 SHV-97 is a beta-lactamase found in Enterococcus faecalis. SHV-97 antibiotic_resistance ARO:3001149 SHV-97 SHV-97 is a beta-lactamase found in Enterococcus faecalis. PMID:21940649 SHV-97 SHV-101 is a beta-lactamase found in Klebsiella pneumoniae. SHV-101 antibiotic_resistance ARO:3001150 SHV-101 SHV-101 is a beta-lactamase found in Klebsiella pneumoniae. PMID:17804424 SHV-101 SHV-102 is an extended spectrum beta-lactamase found in E. coli. SHV-102 antibiotic_resistance ARO:3001151 SHV-102 SHV-102 is an extended spectrum beta-lactamase found in E. coli. PMID:18566158 SHV-102 SHV-103 is a beta-lactamase that has been found in clinical isolates. SHV-103 antibiotic_resistance ARO:3001152 SHV-103 SHV-103 is a beta-lactamase that has been found in clinical isolates. PMID:18620848 SHV-103 SHV-104 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-104 antibiotic_resistance ARO:3001153 SHV-104 SHV-104 SHV-105 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-105 antibiotic_resistance ARO:3001154 SHV-105 SHV-105 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19075050 SHV-105 SHV-106 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-106 antibiotic_resistance ARO:3001155 SHV-106 SHV-106 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:19272757 SHV-106 SHV-107 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. SHV-107 antibiotic_resistance ARO:3001156 SHV-107 SHV-107 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-107 SHV-108 is a beta-lactamase found in Klebsiella pneumoniae. SHV-108 antibiotic_resistance ARO:3001157 SHV-108 SHV-108 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 PMID:27598630 SHV-108 SHV-109 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-109 antibiotic_resistance ARO:3001158 SHV-109 SHV-109 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:18725449 SHV-109 SHV-110 is a beta-lactamase found in Klebsiella pneumoniae. SHV-110 antibiotic_resistance ARO:3001159 SHV-110 SHV-110 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19343954 PMID:27598630 SHV-110 SHV-111 is a beta-lactamase found in Klebsiella pneumoniae. SHV-111 antibiotic_resistance ARO:3001160 SHV-111 SHV-111 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19343954 SHV-111 SHV-112 is a beta-lactamase that has been found in clinical isolates. SHV-112 antibiotic_resistance ARO:3001161 SHV-112 SHV-112 is a beta-lactamase that has been found in clinical isolates. PMID:21123157 SHV-112 SHV-113 is a beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3001162 SHV-113 SHV-114 is a beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3001163 SHV-114 SHV-115 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-115 antibiotic_resistance ARO:3001164 SHV-115 SHV-115 SHV-116 is a beta-lactamase that has been found in clinical isolates. SHV-116 antibiotic_resistance ARO:3001165 SHV-116 SHV-116 SHV-117 is a beta-lactamase that has been found in clinical isolates. antibiotic_resistance ARO:3001166 SHV-117 SHV-120 is a beta-lactamase that has been found in clinical isolates. SHV-120 antibiotic_resistance ARO:3001167 SHV-120 SHV-120 SHV-121 is a beta-lactamase that has been found in clinical isolates. Identical to SHV-136. SHV-121 SHV-136 antibiotic_resistance ARO:3001168 SHV-121 SHV-121 SHV-122 is a beta-lactamase that has been found in clinical isolates. SHV-122 antibiotic_resistance ARO:3001169 SHV-122 SHV-122 is a beta-lactamase that has been found in clinical isolates. PMID:21359845 SHV-122 SHV-123 is a beta-lactamase that has been found in clinical isolates. SHV-123 antibiotic_resistance ARO:3001170 SHV-123 SHV-123 is a beta-lactamase that has been found in clinical isolates. PMID:21903826 SHV-123 SHV-124 is a beta-lactamase that has been found in clinical isolates. SHV-124 antibiotic_resistance ARO:3001171 SHV-124 SHV-124 is a beta-lactamase that has been found in clinical isolates. PMID:21903826 SHV-124 SHV-125 is a beta-lactamase that has been found in clinical isolates. SHV-125 antibiotic_resistance ARO:3001172 SHV-125 SHV-125 is a beta-lactamase that has been found in clinical isolates. PMID:21903826 SHV-125 SHV-126 is a beta-lactamase that has been found in clinical isolates. SHV-126 antibiotic_resistance ARO:3001173 SHV-126 SHV-126 is a beta-lactamase that has been found in clinical isolates. PMID:21903826 SHV-126 SHV-127 is a beta-lactamase that has been found in clinical isolates. SHV-127 antibiotic_resistance ARO:3001174 SHV-127 SHV-127 is a beta-lactamase that has been found in clinical isolates. PMID:21903826 SHV-127 SHV-128 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-128 antibiotic_resistance ARO:3001175 SHV-128 SHV-128 SHV-129 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-129 antibiotic_resistance ARO:3001176 SHV-129 SHV-129 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:22322349 SHV-129 SHV-133 is a beta-lactamase. SHV-133 antibiotic_resistance ARO:3001177 SHV-133 SHV-133 is a beta-lactamase. PMID:24475919 SHV-133 SHV-134 is an extended-spectrum beta-lactamase. SHV-134 antibiotic_resistance ARO:3001178 SHV-134 SHV-134 is an extended-spectrum beta-lactamase. PMID:22005997 SHV-134 SHV-135 is a beta-lactamase. SHV-135 antibiotic_resistance ARO:3001179 SHV-135 SHV-135 is a beta-lactamase. PMID:23722448 SHV-135 SHV-137 is a beta-lactamase. SHV-137 antibiotic_resistance ARO:3001181 SHV-137 SHV-137 SHV-140 is a broad-spectrum beta-lactamase. SHV-140 antibiotic_resistance ARO:3001182 SHV-140 SHV-140 SHV-141 is a broad-spectrum beta-lactamase. SHV-141 antibiotic_resistance ARO:3001183 SHV-141 SHV-141 SHV-142 is a beta-lactamase. SHV-142 antibiotic_resistance ARO:3001184 SHV-142 SHV-142 is a beta-lactamase. PMID:22537112 SHV-142 SHV-145 is a beta-lactamase. SHV-145 antibiotic_resistance ARO:3001185 SHV-145 SHV-145 SHV-147 is a beta-lactamase. SHV-147 antibiotic_resistance ARO:3001186 SHV-147 SHV-147 is a beta-lactamase. PMID:23587957 SHV-147 SHV-148 is a beta-lactamase. SHV-148 antibiotic_resistance ARO:3001187 SHV-148 SHV-148 is a beta-lactamase. PMID:23587957 SHV-148 SHV-149 is a beta-lactamase. SHV-149 antibiotic_resistance ARO:3001188 SHV-149 SHV-149 is a beta-lactamase. PMID:23587957 SHV-149 SHV-150 is a beta-lactamase. SHV-150 antibiotic_resistance ARO:3001189 SHV-150 SHV-150 is a beta-lactamase. PMID:23587957 SHV-150 SHV-151 is a beta-lactamase. SHV-151 antibiotic_resistance ARO:3001190 SHV-151 SHV-151 is a beta-lactamase. PMID:23587957 SHV-151 SHV-152 is a beta-lactamase. SHV-152 antibiotic_resistance ARO:3001191 SHV-152 SHV-152 SHV-153 is a beta-lactamase. SHV-153 antibiotic_resistance ARO:3001192 SHV-153 SHV-153 is a beta-lactamase. PMID:23587957 SHV-153 SHV-154 is a beta-lactamase. SHV-154 antibiotic_resistance ARO:3001193 SHV-154 SHV-154 is a beta-lactamase. PMID:23587957 SHV-154 SHV-155 is a beta-lactamase. SHV-155 antibiotic_resistance ARO:3001194 SHV-155 SHV-155 is a beta-lactamase. PMID:23587957 SHV-155 SHV-156 is a beta-lactamase. SHV-156 antibiotic_resistance ARO:3001195 SHV-156 SHV-156 is a beta-lactamase. PMID:23587957 SHV-156 SHV-157 is a beta-lactamase. SHV-157 antibiotic_resistance ARO:3001196 SHV-157 SHV-157 is a beta-lactamase. PMID:23587957 SHV-157 SHV-158 is a beta-lactamase. SHV-158 antibiotic_resistance ARO:3001197 SHV-158 SHV-158 is a beta-lactamase. PMID:23587957 SHV-158 SHV-159 is a beta-lactamase. SHV-159 antibiotic_resistance ARO:3001198 SHV-159 SHV-159 is a beta-lactamase. PMID:23587957 SHV-159 SHV-160 is a beta-lactamase. SHV-160 antibiotic_resistance ARO:3001199 SHV-160 SHV-160 SHV-161 is a beta-lactamase. SHV-161 antibiotic_resistance ARO:3001200 SHV-161 SHV-161 is a beta-lactamase. PMID:23587957 SHV-161 SHV-162 is a beta-lactamase. SHV-162 antibiotic_resistance ARO:3001201 SHV-162 SHV-162 SHV-163 is a beta-lactamase. SHV-163 antibiotic_resistance ARO:3001202 SHV-163 SHV-163 is a beta-lactamase. PMID:23587957 SHV-163 SHV-165 is a beta-lactamase. SHV-165 antibiotic_resistance ARO:3001203 SHV-165 SHV-165 is a beta-lactamase. PMID:23587957 SHV-165 SHV-167 is a beta-lactamase. SHV-167 antibiotic_resistance ARO:3001204 SHV-167 SHV-167 is a beta-lactamase. PMID:24336426 SHV-167 A novel bleomycin resistance protein encoded by a metallo-beta-lactamase-associated ble gene. Expression of BRP(MBL) confers resistance to bleomycin and bleomycin-like antibiotics in Enterobacteriaceae and Acinetobacter, where it is co-expressed with an MBL and controlled by the same promoter region. BRP BRP(MBL) ble blmA blmS antibiotic_resistance ARO:3001205 BRP(MBL) A novel bleomycin resistance protein encoded by a metallo-beta-lactamase-associated ble gene. Expression of BRP(MBL) confers resistance to bleomycin and bleomycin-like antibiotics in Enterobacteriaceae and Acinetobacter, where it is co-expressed with an MBL and controlled by the same promoter region. PMID:18791008 PMID:22290943 BRP(MBL) Inactivation of an antibiotic by formation of a complex, preventing interaction of the antibiotic with its target. antibiotic_resistance ARO:3001206 antibiotic inactivation by sequestration Inactivation of an antibiotic by formation of a complex, preventing interaction of the antibiotic with its target. PMID:18791008 A gene whose product inactivates an antibiotic by formation of a complex, preventing interaction of the antibiotic with its target. antibiotic_resistance ARO:3001207 gene involved in antibiotic sequestration In methicillin sensitive S. aureus (MSSA), beta-lactams bind to native penicillin-binding proteins (PBPs) and disrupt synthesis of the cell membrane's peptidoglycan layer. In methicillin resistant S. aureus (MRSA), foreign PBP2a acquired by lateral gene transfer is able to perform peptidoglycan synthesis in the presence of beta-lactams. antibiotic_resistance ARO:3001208 methicillin resistant PBP2 In methicillin sensitive S. aureus (MSSA), beta-lactams bind to native penicillin-binding proteins (PBPs) and disrupt synthesis of the cell membrane's peptidoglycan layer. In methicillin resistant S. aureus (MRSA), foreign PBP2a acquired by lateral gene transfer is able to perform peptidoglycan synthesis in the presence of beta-lactams. PMID:12389036 PMID:15226303 PMID:21641281 PMID:22941897 PMID:2708325 PMID:6563036 A foreign PBP2a acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams. mecALGA251 mecC antibiotic_resistance ARO:3001209 mecC A foreign PBP2a acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams. PMID:21641281 PMID:22941897 PMID:23274660 PMID:28069659 mecC Multidrug resistance protein MdtM. ECK4328 JW4300 mdtM yjiO antibiotic_resistance ARO:3001214 mdtM Multidrug resistance protein MdtM. PMID:23221628 mdtM Multidrug resistance protein MdtH. mdtH antibiotic_resistance ARO:3001216 mdtH Multidrug resistance protein MdtH. PMID:15686558 PMID:19678712 mdtH Alternative dihydropteroate synthase dfr present on plasmids produces alternate proteins that are less sensitive to trimethoprim from inhibiting its role in folate synthesis, thus conferring trimethoprim resistance. antibiotic_resistance ARO:3001218 trimethoprim resistant dihydrofolate reductase dfr Alternative dihydropteroate synthase dfr present on plasmids produces alternate proteins that are less sensitive to trimethoprim from inhibiting its role in folate synthesis, thus conferring trimethoprim resistance. PMID:20169085 Elfamycins are molecules that inhibit bacterial elongation factor Tu (EF-Tu), a key protein which brings aminoacyl-tRNA (aa-tRNA) to the ribosome during protein synthesis. Elfamycins defined by their target (EF-Tu), rather than a conserved chemical backbone. Elfamycins follow two mechanisms to disrupt protein synthesis: 1. kirromycins and enacyloxin fix EF-Tu in the GTP bound conformation and lock EF-Tu onto the ribosome, and 2. pulvomycin and GE2270 cover the binding site of aa-tRNA disallowing EF-Tu from being charged with aa-tRNA. All elfamycins cause increased the affinity of EF-Tu for GTP. elfamycin antibiotic_resistance ARO:3001219 elfamycin antibiotic Elfamycins are molecules that inhibit bacterial elongation factor Tu (EF-Tu), a key protein which brings aminoacyl-tRNA (aa-tRNA) to the ribosome during protein synthesis. Elfamycins defined by their target (EF-Tu), rather than a conserved chemical backbone. Elfamycins follow two mechanisms to disrupt protein synthesis: 1. kirromycins and enacyloxin fix EF-Tu in the GTP bound conformation and lock EF-Tu onto the ribosome, and 2. pulvomycin and GE2270 cover the binding site of aa-tRNA disallowing EF-Tu from being charged with aa-tRNA. All elfamycins cause increased the affinity of EF-Tu for GTP. PMID:12370016 PMID:16876786 Factumycin is a kirromycin-like antibiotic produced by Kitasatospora setae and Streptomyces strains. Its biosynthetic cluster has been characterized which has interesting acetyl transferase domains in trans, or outside of the polyketide synthase domains. Factumycin has specific, rather than broad spectrum, antibacterial properties, especially targeting various Acinetobacter baumanii strains. pubchem.compound:135410114 antibiotic_resistance ARO:3001220 factumycin Factumycin is a kirromycin-like antibiotic produced by Kitasatospora setae and Streptomyces strains. Its biosynthetic cluster has been characterized which has interesting acetyl transferase domains in trans, or outside of the polyketide synthase domains. Factumycin has specific, rather than broad spectrum, antibacterial properties, especially targeting various Acinetobacter baumanii strains. PMID:7166535 A macrolide antibiotic from Streptomyces narbonensis subsp. josamyceticus. The drug has antimicrobial activity against a wide spectrum of pathogens. pubchem.compound:5284579 antibiotic_resistance ARO:3001221 josamycin Produced by Streptomyces bikiniensis. pubchem.compound:6436271 antibiotic_resistance ARO:3001222 chalcomycin Produced by Streptomyces mycarofaciens. pubchem.compound:5282169 antibiotic_resistance ARO:3001223 midecamycin Produced by Micromonospora griseorubida. pubchem.compound:6447311 antibiotic_resistance ARO:3001224 mycinamicin Produced by Micromonospora megalomicia. pubchem.compound:474871 antibiotic_resistance ARO:3001225 megalomycin Produced by Streptomyces narbonensis. pubchem.compound:5282036 antibiotic_resistance ARO:3001226 narbomycin Kitasamycin is a macrolide antibiotic and is produced by Streptoverticillium kitasatoense. The drug has antimicrobial activity against a wide spectrum of pathogens. pubchem.compound:5282189 antibiotic_resistance ARO:3001227 kitasamycin Kitasamycin is a macrolide antibiotic and is produced by Streptoverticillium kitasatoense. The drug has antimicrobial activity against a wide spectrum of pathogens. PMID:1838760 Produced by Streptomyces halstedii and Streptomyces thermotolerans. pubchem.compound:5287879 antibiotic_resistance ARO:3001228 carbomycin Produced by Micromonospora rosaria. pubchem.compound:6537204 antibiotic_resistance ARO:3001229 rosaramicin Produced by Streptomyces caelestis. pubchem.compound:6440864 antibiotic_resistance ARO:3001230 niddamycin Produced by Streptomyces caelestis, which also produces the macrolide niddamycin. pubchem.compound:220087 antibiotic_resistance ARO:3001231 celesticetin Produced by Streptomyces venezuelae ATCC 15439. pubchem.compound:5282034 antibiotic_resistance ARO:3001232 methymycin Produced by Streptomyces venezuelae ATCC 15439. pubchem.compound:5282037 antibiotic_resistance ARO:3001233 pikromycin Kirromycin, also known as mocimycin, is the representative molecule of its own class of elfamycins which is composed of more than 10 analogs. Kirromycin binds to the domain 1,2 interface of elongation factor Tu. This interaction maintains the EF-Tu*GTP conformation even after GTP is hydrolyzed to GDP. EF-Tu*GDP normally releases aa-tRNA and then exits the ribosome; however, kirromycin*EF-Tu*GDP*aa-tRNA forms a strong complex and remains bound to the ribosome, prohibits translocation of the peptide chain and translation is halted. pubchem.compound:135452521 mocimycin antibiotic_resistance ARO:3001234 kirromycin Kirromycin, also known as mocimycin, is the representative molecule of its own class of elfamycins which is composed of more than 10 analogs. Kirromycin binds to the domain 1,2 interface of elongation factor Tu. This interaction maintains the EF-Tu*GTP conformation even after GTP is hydrolyzed to GDP. EF-Tu*GDP normally releases aa-tRNA and then exits the ribosome; however, kirromycin*EF-Tu*GDP*aa-tRNA forms a strong complex and remains bound to the ribosome, prohibits translocation of the peptide chain and translation is halted. PMID:2499247 PMID:3356609 PMID:337296 PMID:3904612 PMID:4373734 PMID:7925958 PMID:9043138 Aurodox is an elongation factor Tu inhibiting antibiotic. It was first referred to as X-5108. It is produced by Streptomyces goldiniensis var. goldiniensis and is active primarily against gram-positive bacteria. pubchem.compound:135509117 antibiotic X-5108 goldinodox goldinomycin mocimycin antibiotic_resistance ARO:3001235 aurodox Aurodox is an elongation factor Tu inhibiting antibiotic. It was first referred to as X-5108. It is produced by Streptomyces goldiniensis var. goldiniensis and is active primarily against gram-positive bacteria. PMID:4781274 Efrotomycin is produced by Streptomyces lactamodurans NRRL 3802. This kirromycin-like antibiotic is used in animal agriculture, especially in the production of swine. Generally gram negative bacteria are susceptible to efrotomycin, while gram positive bacteria are resistant. pubchem.compound:135434844 antibiotic_resistance ARO:3001236 efrotomycin Efrotomycin is produced by Streptomyces lactamodurans NRRL 3802. This kirromycin-like antibiotic is used in animal agriculture, especially in the production of swine. Generally gram negative bacteria are susceptible to efrotomycin, while gram positive bacteria are resistant. PMID:1590753 PMID:16677683 PMID:8515234 PMID:950325 GE2270A is the model molecule of cyclic thiazolyl peptide elfamycins. GE2270A is produced by Planobispora rosea. Biosynthesis of the molecule has been shown to originate as a ribosomally synthesized peptide that undergoes significant post-translational modification. Clinical use of cyclic thiazolyl peptides is hindered by their low water solubility and bioavailability. pubchem.compound:16129640 antibiotic_resistance ARO:3001237 GE2270A GE2270A is the model molecule of cyclic thiazolyl peptide elfamycins. GE2270A is produced by Planobispora rosea. Biosynthesis of the molecule has been shown to originate as a ribosomally synthesized peptide that undergoes significant post-translational modification. Clinical use of cyclic thiazolyl peptides is hindered by their low water solubility and bioavailability. PMID:10625477 PMID:16734421 PMID:20111801 PMID:20522549 PMID:8899707 Enacyloxin IIa is structurally distinct but acts in a similar mechanism to kirromycin-like elfamycins. It prohibits the transfer of the amino acid at the A site to the elongating peptide chain. It is most likely that the mechanism of action is that EF-Tu*GDP is locked in the EF-Tu*GTP form, and EF-Tu*GDP*aa-tRNA is immobilized on the ribosome. It is an open question whether enacyloxin IIa actually belongs to the kirromycin-like group of elfamycins due to their high similarity. pubchem.compound:6444164 antibiotic_resistance ARO:3001242 enacyloxin IIa Enacyloxin IIa is structurally distinct but acts in a similar mechanism to kirromycin-like elfamycins. It prohibits the transfer of the amino acid at the A site to the elongating peptide chain. It is most likely that the mechanism of action is that EF-Tu*GDP is locked in the EF-Tu*GTP form, and EF-Tu*GDP*aa-tRNA is immobilized on the ribosome. It is an open question whether enacyloxin IIa actually belongs to the kirromycin-like group of elfamycins due to their high similarity. PMID:12370016 PMID:8665868 Kirrothricin is produced by Streptomyces cinnamoneus and is structurally related to kirromycin, aurodox, heneicomycin and shares a similar spectrum of antibacterial activity. pubchem.compound:54679291 antibiotic_resistance ARO:3001246 kirrothricin Kirrothricin is produced by Streptomyces cinnamoneus and is structurally related to kirromycin, aurodox, heneicomycin and shares a similar spectrum of antibacterial activity. PMID:7142013 Azimycin is produced by Streptomyces diastatochromogenes ATCC 31013. pubchem.compound:5743 antibiotic_resistance ARO:3001247 azimycin Azimycin is produced by Streptomyces diastatochromogenes ATCC 31013. PMID:3904612 Dihydromocimycin is produced by Streptomyces ramocissimus CBS190.69. pubchem.compound:54679334 antibiotic_resistance ARO:3001248 dihydromocimycin Dihydromocimycin is produced by Streptomyces ramocissimus CBS190.69. PMID:2272911 PMID:3781906 Phenelfamycin A was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin A has a monosaccaride moeity and is isomeric with phenelfamycin B. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. pubchem.compound:6443943 antibiotic_resistance ARO:3001249 phenelfamycin A Phenelfamycin A was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin A has a monosaccaride moeity and is isomeric with phenelfamycin B. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. PMID:2921230 PMID:3192489 PMID:3192490 Phenelfamycin B was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin B has a monosaccaride moeity and is isomeric with phenelfamycin A. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. pubchem.compound:6443944 antibiotic_resistance ARO:3001250 phenelfamycin B Phenelfamycin B was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin B has a monosaccaride moeity and is isomeric with phenelfamycin A. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. PMID:2921230 PMID:3192489 PMID:3192490 Phenelfamycin C was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin C has a disaccaride moeity and is isomeric with phenelfamycin D. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. pubchem.compound:6443945 antibiotic_resistance ARO:3001251 phenelfamycin C Phenelfamycin C was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin C has a disaccaride moeity and is isomeric with phenelfamycin D. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. PMID:2921230 PMID:3192489 PMID:3192490 Phenelfamycin D was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin D has a disaccaride moeity and is isomeric with phenelfamycin C. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. antibiotic_resistance ARO:3001252 phenelfamycin D Phenelfamycin D was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin D has a disaccaride moeity and is isomeric with phenelfamycin C. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. PMID:2921230 PMID:3192489 PMID:3192490 Phenelfamycin E was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin E has a trisaccaride moeity and is isomeric with phenelfamycin F. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. Phenelfamycin E and F are the most potent of the phenelfamycins. pubchem.compound:71433564 antibiotic_resistance ARO:3001253 phenelfamycin E Phenelfamycin E was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin E has a trisaccaride moeity and is isomeric with phenelfamycin F. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. Phenelfamycin E and F are the most potent of the phenelfamycins. PMID:2921230 PMID:3192489 PMID:3192490 Phenelfamycin F was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin F has a trisaccaride moeity and is isomeric with phenelfamycin E. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. Phenelfamycin E and F are the most potent of the phenelfamycins. pubchem.compound:90478571 antibiotic_resistance ARO:3001256 phenelfamycin F Phenelfamycin F was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin F has a trisaccaride moeity and is isomeric with phenelfamycin E. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. Phenelfamycin E and F are the most potent of the phenelfamycins. PMID:2921230 PMID:3192489 PMID:3192490 Unphenelfamycin was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Unphenelfamycin has a monosaccaride moeity and lacks the phenacetyl moeity present in the other phenelfamycins. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. pubchem.compound:6443942 antibiotic_resistance ARO:3001257 unphenelfamycin Unphenelfamycin was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Unphenelfamycin has a monosaccaride moeity and lacks the phenacetyl moeity present in the other phenelfamycins. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. PMID:2921230 PMID:3192489 PMID:3192490 L-681217 is a kirromycin-like antibiotic produced by Streptomyces cattleya. Its biosynthetic gene cluster is characterized. pubchem.compound:6439903 antibiotic_resistance ARO:3001258 L-681,217 L-681217 is a kirromycin-like antibiotic produced by Streptomyces cattleya. Its biosynthetic gene cluster is characterized. PMID:3781906 GE37468 is a thiazolyl peptide produced by Streptomyces ATCC 55365. GE37468 is produced by post-transcription modification of a ribosomally synthesized preprotein, of which the biosynthetic gene cluster has been elucidated. pubchem.compound:101808822 antibiotic_resistance ARO:3001259 GE37468 GE37468 is a thiazolyl peptide produced by Streptomyces ATCC 55365. GE37468 is produced by post-transcription modification of a ribosomally synthesized preprotein, of which the biosynthetic gene cluster has been elucidated. PMID:21788474 Amythiamicin A is a cyclic thiazolyl peptide antibiotic with a structure similar to GE2270A. Amythiamicin B, C, and D also exist, but are not discussed further here. Amythiamicin A was shown to have the highest activity in cell free protein synthesis assays. pubchem.compound:198789 antibiotic_resistance ARO:3001260 amythiamicin A Amythiamicin A is a cyclic thiazolyl peptide antibiotic with a structure similar to GE2270A. Amythiamicin B, C, and D also exist, but are not discussed further here. Amythiamicin A was shown to have the highest activity in cell free protein synthesis assays. PMID:7706132 Heneicomycin is a kirromycin-like antibiotic, isolated from Streptomyces filipinensis. It is structurally related to kirromycin, aurodox and efrotomycin. pubchem.compound:135612719 antibiotic_resistance ARO:3001264 heneicomycin Heneicomycin is a kirromycin-like antibiotic, isolated from Streptomyces filipinensis. It is structurally related to kirromycin, aurodox and efrotomycin. PMID:1917698 PMID:468738 Erm(30) confers a MLSb resistant phenotype. Along with erm(31), these genes are responsible for self-resistance in the pikromycin/narbomycin/methymycin/neomethymycin producer, Streptomyces venezuelae. Erm(30) Erm30 antibiotic_resistance ARO:3001265 Erm(30) Erm(30) confers a MLSb resistant phenotype. Along with erm(31), these genes are responsible for self-resistance in the pikromycin/narbomycin/methymycin/neomethymycin producer, Streptomyces venezuelae. PMID:14674753 PMID:9770448 Erm(30) A gentamicin-group aminoglycoside isolated from Micromonospora. pubchem.compound:512877 antibiotic_resistance ARO:3001294 verdamicin A semisynthetic genamicin-group aminoglycoside, derived from verdamicin. pubchem.compound:52948322 antibiotic_resistance ARO:3001295 vertilimicin A semisynthetic genamicin-group aminoglycoside, derived from verdamicin. PMID:19635958 An unusual aminoglycoside because the cyclitol ring is not amino substituted; it was discovered as a fermentation product of Streptomyces kasugaensis. pubchem.compound:65174 kasugamicin antibiotic_resistance ARO:3001296 kasugamycin Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides. antibiotic_resistance ARO:3001298 non-erm 23S ribosomal RNA methyltransferase (G748) TlrB is a methyltransferase found in Streptomyces fradiae and confers resistance to mycinamicin, tylosin and lincosamides. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering). TlrB is found in the tylosin biosynthetic cluster and is one mechanism by which S. fradiae protects itself from self-destruction when producing this macrolide. Sfra_tlrB_TYL antibiotic_resistance ARO:3001299 tlrB conferring tylosin resistance TlrB is a methyltransferase found in Streptomyces fradiae and confers resistance to mycinamicin, tylosin and lincosamides. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering). TlrB is found in the tylosin biosynthetic cluster and is one mechanism by which S. fradiae protects itself from self-destruction when producing this macrolide. PMID:10348045 PMID:10972803 Sfra_tlrB_TYL myrA is a methyltransferase found in Micromonospora griseorubida and confers resistance to mycinamicin and tylosin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering) of 23S ribosomal RNA. MyrA is found in the mycinamicin biosynthetic cluster and is one mechanism by which M. griseorubida protects itself from self-destruction when producing this macrolide. myrA antibiotic_resistance ARO:3001300 myrA myrA is a methyltransferase found in Micromonospora griseorubida and confers resistance to mycinamicin and tylosin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering) of 23S ribosomal RNA. MyrA is found in the mycinamicin biosynthetic cluster and is one mechanism by which M. griseorubida protects itself from self-destruction when producing this macrolide. PMID:12417742 PMID:8163173 myrA RlmA(II) is a methyltransferase found in Streptococcus pneumoniae and confers resistance to tylosin and mycinamicin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering) of 23S ribosomal RNA. RlmA(II) antibiotic_resistance ARO:3001301 RlmA(II) RlmA(II) is a methyltransferase found in Streptococcus pneumoniae and confers resistance to tylosin and mycinamicin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering) of 23S ribosomal RNA. PMID:12514124 PMID:18406425 RlmA(II) ChrB is a methyltransferase found in Streptomyces bikiniensis and confers resistance to chalcomycin, mycinamicin, and tylosin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering). chrB is found in the chalcomycin biosynthetic cluster and is responsible for self-resistance in S. bikiniensis. chrB antibiotic_resistance ARO:3001302 chrB ChrB is a methyltransferase found in Streptomyces bikiniensis and confers resistance to chalcomycin, mycinamicin, and tylosin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering). chrB is found in the chalcomycin biosynthetic cluster and is responsible for self-resistance in S. bikiniensis. PMID:15561847 chrB ErmO (gene srmA) is a methyltransferase found in the spiramycin producer Streptomyces ambofaciens. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is responsible for self-resistance to spiramycin. ErmO-srmA srmA antibiotic_resistance ARO:3001303 ErmO-srmA ErmO (gene srmA) is a methyltransferase found in the spiramycin producer Streptomyces ambofaciens. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is responsible for self-resistance to spiramycin. PMID:10517588 PMID:1761231 ErmO-srmA ErmS is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers two methyl groups. The gene is found within the tylosin biosynthetic cluster and is responsible for self-resistance. ErmS ermSF tlrA antibiotic_resistance ARO:3001304 ErmS ErmS is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers two methyl groups. The gene is found within the tylosin biosynthetic cluster and is responsible for self-resistance. PMID:2753855 PMID:3020383 PMID:3127381 PMID:7495815 PMID:7534372 PMID:7961463 ErmS ErmU is a methyltransferase found in the lincomycin producer Streptomyces lincolnensis. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is found in the lincomycin biosynthetic cluster and is responsible for self-resistance. ErmU lrmB antibiotic_resistance ARO:3001305 ErmU ErmU is a methyltransferase found in the lincomycin producer Streptomyces lincolnensis. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is found in the lincomycin biosynthetic cluster and is responsible for self-resistance. PMID:1328813 PMID:8577249 ErmU ErmW is a methyltransferase found in the mycinamicin producer Micromonospora griseorubida. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the mycinamicin biosynthetic cluster and is responsible for self-resistance. ErmW myrB antibiotic_resistance ARO:3001306 ErmW ErmW is a methyltransferase found in the mycinamicin producer Micromonospora griseorubida. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the mycinamicin biosynthetic cluster and is responsible for self-resistance. PMID:12583909 PMID:8163173 ErmW vgbA inactivates streptogramin B-type antibiotics by linearizing the lactone ring on the ester bond using an elimination mechanism, thus conferring resistance to these compounds. PDB:2Z2P vgbA vgh antibiotic_resistance ARO:3001307 vgbA vgbA inactivates streptogramin B-type antibiotics by linearizing the lactone ring on the ester bond using an elimination mechanism, thus conferring resistance to these compounds. PMID:11467949 PMID:15734650 PMID:17563376 vgbA VgbB inactivates streptogramin B-type antibiotics by linearizing the lactone ring on the ester bond through an elimination mechanism, thus conferring resistance. vgbB antibiotic_resistance ARO:3001308 vgbB VgbB inactivates streptogramin B-type antibiotics by linearizing the lactone ring on the ester bond through an elimination mechanism, thus conferring resistance. PMID:18341294 vgbB Cyclic thiazolyl peptide elfamycins inhibit protein synthesis by preventing the formation of the EF-Tu*GTP-aa-tRNA ternary complex, a mechanism similar to that of pulvomycin. There are non-elfamycin cyclic thiazolyl peptide antibiotics which inhibit protein synthesis by by targeting the 50S ribosomal subunit and are not discussed here further. antibiotic_resistance ARO:3001309 cyclic thiazolyl peptide elfamycin Cyclic thiazolyl peptide elfamycins inhibit protein synthesis by preventing the formation of the EF-Tu*GTP-aa-tRNA ternary complex, a mechanism similar to that of pulvomycin. There are non-elfamycin cyclic thiazolyl peptide antibiotics which inhibit protein synthesis by by targeting the 50S ribosomal subunit and are not discussed here further. PMID:12370016 Kirromycin-like antibiotics bind to the domain 1,2 interface of elongation factor Tu. This interaction maintains the EF-Tu*GTP conformation even after GTP is hydrolyzed to GDP. EF-Tu*GDP normally releases aa-tRNA and then exits the ribosome; however, kirromycin*EF-Tu*GDP*aa-tRNA forms a strong complex and remains bound to the ribosome, prohibits translocation of the peptide chain and translation is halted. antibiotic_resistance ARO:3001310 kirromycin-like antibiotics Sequence variants of elongation factor Tu that confer resistance to elfamycin antibiotics. antibiotic_resistance ARO:3001312 elfamycin resistant EF-Tu Sequence variants of elongation factor Tu that confer resistance to elfamycin antibiotics. PMID:10610785 PMID:12370016 PMID:7525272 PMID:7925958 PMID:7957075 PMID:8899707 Efflux protein facT confers resistance to factumycin. The gene has been heterologously expressed in S. coelicolor and its function confirmed. It is possible that this gene can export other kirromycin-like elfamycins, but this has not been tested. facT antibiotic_resistance ARO:3001313 facT Efflux protein facT confers resistance to factumycin. The gene has been heterologously expressed in S. coelicolor and its function confirmed. It is possible that this gene can export other kirromycin-like elfamycins, but this has not been tested. DOI:10.1039/C2MD20038D facT Retapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections. pubchem.compound:6918462 antibiotic_resistance ARO:3001314 retapamulin Retapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections. PMID:16801451 PMID:16940066 PMID:17065625 PMID:17360517 Two semi-synthetic pleuromutilin derivatives, tiamulin and valnemulin, have been developed as antibiotics for veterinary use. pubchem.compound:9850878 antibiotic_resistance ARO:3001315 valnemulin Two semi-synthetic pleuromutilin derivatives, tiamulin and valnemulin, have been developed as antibiotics for veterinary use. PMID:11555289 PMID:22070694 Azamulin is a semi-synthetic pleuromutilin derivative that failed Stage 1 clinical trials due to poor bioavailability. pubchem.compound:16072188 antibiotic_resistance ARO:3001316 azamulin Pleuromutilin is a natural product antibiotic produced by Clitopilus passeckerianus. Related antibiotics of clinical significance, such as tiamulin and retapamulin, are semi-synthetic derivatives of this compound. pubchem.compound:31326 antibiotic_resistance ARO:3001317 pleuromutilin Pleuromutilin is a natural product antibiotic produced by Clitopilus passeckerianus. Related antibiotics of clinical significance, such as tiamulin and retapamulin, are semi-synthetic derivatives of this compound. PMID:23589420 Narrow spectrum macrocyclic antibiotics, in the general sense, is a cyclic molecule containing more than 12 atoms in the macrocyclic lactone ring. antibiotic_resistance ARO:3001318 macrocyclic antibiotic Narrow spectrum macrocyclic antibiotics, in the general sense, is a cyclic molecule containing more than 12 atoms in the macrocyclic lactone ring. PMID:22142153 PMID:24864039 A narrow spectrum antibiotic effective against Clostridioides difficile infection (CDI). It is active against gram positive and gram negative bacteria by inhibiting RNA polymerase's switch region leading to cell death. pubchem.compound:10034073 OPT-80 antibiotic_resistance ARO:3001319 fidaxomicin A narrow spectrum antibiotic effective against Clostridioides difficile infection (CDI). It is active against gram positive and gram negative bacteria by inhibiting RNA polymerase's switch region leading to cell death. PMID:21288078 PMID:21862392 PMID:22752863 PMID:24064437 SB22484 antibiotics are of the same chemical group as kirromycins. SB22484 antibiotics are produced by Streptomyces sp. NRRL 15496. There are two SB22484 isomers with the same UV absorption spectra, but differing molecular masses. These antibiotics are strongly active against Neisseria species, but also show activity against Streptococci, and Haemophilus influenzae. pubchem.compound:53418992 antibiotic_resistance ARO:3001320 SB22484 SB22484 antibiotics are of the same chemical group as kirromycins. SB22484 antibiotics are produced by Streptomyces sp. NRRL 15496. There are two SB22484 isomers with the same UV absorption spectra, but differing molecular masses. These antibiotics are strongly active against Neisseria species, but also show activity against Streptococci, and Haemophilus influenzae. PMID:2272911 UK-69,753 is a glycosylated form of factumycin. The disaccharide moiety of UK-69,753 is virtually identical to that of efrotomycin, another member of this class of antibiotics. UK-69,753 has been shown to have strong in vitro and in vivo activity toward a swine pathogen, Treponema hyodysenteriae. pubchem.compound:54681521 antibiotic_resistance ARO:3001321 UK-69,753 UK-69,753 is a glycosylated form of factumycin. The disaccharide moiety of UK-69,753 is virtually identical to that of efrotomycin, another member of this class of antibiotics. UK-69,753 has been shown to have strong in vitro and in vivo activity toward a swine pathogen, Treponema hyodysenteriae. PMID:2584145 Phenelfamycin G is produced by Streptomyces albospinus strain Acta 3619. Phenelfamycin G and H are isomeric and similar to phenelfamycin E and F only with the addition of a hydroxyl group at position C-30. Phenelfamycin G and H have a narrow antibacterial spectrum with potent activity against Cutibacterium acnes. pubchem.compound:102306422 antibiotic_resistance ARO:3001322 phenelfamycin G Phenelfamycin G is produced by Streptomyces albospinus strain Acta 3619. Phenelfamycin G and H are isomeric and similar to phenelfamycin E and F only with the addition of a hydroxyl group at position C-30. Phenelfamycin G and H have a narrow antibacterial spectrum with potent activity against Cutibacterium acnes. PMID:21285962 Phenelfamycin H is produced by Streptomyces albospinus strain Acta 3619. Phenelfamycin G and H are isomeric and similar to phenelfamycin E and F only with the addition of a hydroxyl group at position C-30. Phenelfamycin G and H have a narrow antibacterial spectrum with potent activity against Cutibacterium acnes. pubchem.compound:102306423 antibiotic_resistance ARO:3001323 phenelfamycin H Phenelfamycin H is produced by Streptomyces albospinus strain Acta 3619. Phenelfamycin G and H are isomeric and similar to phenelfamycin E and F only with the addition of a hydroxyl group at position C-30. Phenelfamycin G and H have a narrow antibacterial spectrum with potent activity against Cutibacterium acnes. PMID:21285962 One of a small group of kirromycin-like elfamycins which lack the pyridone moiety. Ganefromycin is produced by Streptomyces lydicus spp. tanzanius, and was considered for use as a growth promoting antibiotic in agriculture. pubchem.compound:134158049 antibiotic_resistance ARO:3001326 ganefromycin One of a small group of kirromycin-like elfamycins which lack the pyridone moiety. Ganefromycin is produced by Streptomyces lydicus spp. tanzanius, and was considered for use as a growth promoting antibiotic in agriculture. PMID:8557574 A multidrug and toxic compound extrusions (MATE) transporter conferring resistance to norfloxacin, doxorubicin and acriflavine. MdtK NorE YdhE norM antibiotic_resistance ARO:3001327 MdtK A multidrug and toxic compound extrusions (MATE) transporter conferring resistance to norfloxacin, doxorubicin and acriflavine. PMID:16359323 MdtK Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. Ecol_mdfA cmlA cmr antibiotic_resistance ARO:3001328 Escherichia coli mdfA Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. PMID:26238402 PMID:9811673 Ecol_mdfA The MdtG protein, also named YceE, appears to be a member of the major facilitator superfamily of transporters, and it has been reported, when overexpressed, to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. mdtG yceE antibiotic_resistance ARO:3001329 mdtG The MdtG protein, also named YceE, appears to be a member of the major facilitator superfamily of transporters, and it has been reported, when overexpressed, to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. PMID:20008776 mdtG From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001331 SHV-54 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001332 SHV-58 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001333 SHV-68 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001334 SHV-87 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001335 SHV-88 SHV-98 is a beta-lactamase found in Klebsiella pneumoniae. SHV-98 antibiotic_resistance ARO:3001336 SHV-98 SHV-98 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21415202 SHV-98 SHV-99 is a beta-lactamase found in Klebsiella pneumoniae. SHV-99 antibiotic_resistance ARO:3001337 SHV-99 SHV-99 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21415202 PMID:27598630 SHV-99 SHV-100 is a beta-lactamase found in Klebsiella pneumoniae. It differs from SHV-1 by a 35SESQLSGRVGMIE36 insertion. SHV-100 antibiotic_resistance ARO:3001338 SHV-100 SHV-100 is a beta-lactamase found in Klebsiella pneumoniae. It differs from SHV-1 by a 35SESQLSGRVGMIE36 insertion. PMID:21415202 SHV-100 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001339 SHV-118 From the Lahey list of beta-lactamases. Not yet released. SHV-119 antibiotic_resistance ARO:3001340 SHV-119 SHV-119 From the Lahey list of beta-lactamases. Not yet released. SHV-132 antibiotic_resistance ARO:3001341 SHV-132 SHV-132 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001342 SHV-138 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001343 SHV-139 From the Lahey list of beta-lactamases. SHV-143 antibiotic_resistance ARO:3001344 SHV-143 SHV-143 SHV-144 is a beta-lactamase found in Klebsiella pneumoniae. SHV-144 antibiotic_resistance ARO:3001345 SHV-144 SHV-144 is a beta-lactamase found in Klebsiella pneumoniae. PMID:24270152 SHV-144 From the Lahey list of beta-lactamases. Not yet released. SHV-146 antibiotic_resistance ARO:3001346 SHV-146 SHV-146 From the Lahey list of beta-lactamases. SHV-164 antibiotic_resistance ARO:3001347 SHV-164 SHV-164 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001348 SHV-166 SHV-174 is a beta-lactamase found in Enterobacteriaceae. antibiotic_resistance ARO:3001349 SHV-174 From the Lahey list of beta-lactamases. Not yet released. SHV-180 antibiotic_resistance ARO:3001350 SHV-180 SHV-180 From the Lahey list of beta-lactamases. Not yet released. SHV-183 antibiotic_resistance ARO:3001351 SHV-183 SHV-183 From the Lahey list of beta-lactamases. SHV-168 antibiotic_resistance ARO:3001352 SHV-168 From the Lahey list of beta-lactamases. PMID:23587779 SHV-168 From the Lahey list of beta-lactamases. antibiotic_resistance ARO:3001353 SHV-169 From the Lahey list of beta-lactamases. antibiotic_resistance ARO:3001354 SHV-170 From the Lahey list of beta-lactamases. SHV-171 antibiotic_resistance ARO:3001355 SHV-171 SHV-171 From the Lahey list of beta-lactamases. SHV-172 antibiotic_resistance ARO:3001356 SHV-172 SHV-172 From the Lahey list of beta-lactamases. SHV-173 antibiotic_resistance ARO:3001357 SHV-173 SHV-173 From the Lahey list of beta-lactamases. antibiotic_resistance ARO:3001358 SHV-175 From the Lahey list of beta-lactamases. antibiotic_resistance ARO:3001359 SHV-176 From the Lahey list of beta-lactamases. PMID:24403301 From the Lahey list of beta-lactamases. antibiotic_resistance ARO:3001360 SHV-177 From the Lahey list of beta-lactamases. SHV-178 antibiotic_resistance ARO:3001361 SHV-178 SHV-178 From the Lahey list of beta-lactamases. SHV-179 antibiotic_resistance ARO:3001362 SHV-179 SHV-179 From the Lahey list of beta-lactamases. antibiotic_resistance ARO:3001363 SHV-181 From the Lahey list of beta-lactamases. SHV-182 antibiotic_resistance ARO:3001364 SHV-182 SHV-182 From the Lahey list of beta-lactamases. antibiotic_resistance ARO:3001365 SHV-184 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001366 TEM-100 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001367 TEM-119 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001368 TEM-140 TEM-153 is a beta-lactamase found in Enterobacteriaceae. TEM-153 antibiotic_resistance ARO:3001369 TEM-153 TEM-153 is a beta-lactamase found in Enterobacteriaceae. PMID:23579192 TEM-153 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001370 TEM-175 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001371 TEM-179 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001372 TEM-180 TEM-182 is a beta-lactamase found in clinical isolates of H. parainfluenzae. TEM-182 antibiotic_resistance ARO:3001373 TEM-182 TEM-182 is a beta-lactamase found in clinical isolates of H. parainfluenzae. PMID:23335113 TEM-182 TEM-185 is a beta-lactamase found in E. coli. TEM-185 antibiotic_resistance ARO:3001374 TEM-185 TEM-185 is a beta-lactamase found in E. coli. PMID:22491692 TEM-185 From the Lahey list of beta-lactamases. Not yet released. TEM-184 antibiotic_resistance ARO:3001375 TEM-184 TEM-184 From the Lahey list of beta-lactamases. Not yet released. TEM-196 antibiotic_resistance ARO:3001376 TEM-196 TEM-196 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001377 TEM-200 TEM-201 is a beta-lactamase found in Enterobacteriaceae. TEM-201 antibiotic_resistance ARO:3001378 TEM-201 TEM-201 is a beta-lactamase found in Enterobacteriaceae. PMID:24701189 TEM-201 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001379 TEM-202 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001380 TEM-203 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001381 TEM-204 From the Lahey list of beta-lactamases. Not yet released. TEM-205 antibiotic_resistance ARO:3001382 TEM-205 TEM-205 From the Lahey list of beta-lactamases. Not yet released. TEM-206 antibiotic_resistance ARO:3001383 TEM-206 TEM-206 From the Lahey list of beta-lactamases. Not yet released. TEM-207 antibiotic_resistance ARO:3001384 TEM-207 TEM-207 From the Lahey list of beta-lactamases. Not yet released. TEM-208 antibiotic_resistance ARO:3001385 TEM-208 TEM-208 From the Lahey list of beta-lactamases. Not yet released. TEM-209 antibiotic_resistance ARO:3001386 TEM-209 TEM-209 TEM-210. TEM-210 antibiotic_resistance ARO:3001387 TEM-210 TEM-210 From the Lahey list of beta-lactamases. Not yet released. TEM-211 antibiotic_resistance ARO:3001388 TEM-211 TEM-211 From the Lahey list of beta-lactamases. Not yet released. TEM-212 antibiotic_resistance ARO:3001389 TEM-212 TEM-212 From the Lahey list of beta-lactamases. Not yet released. TEM-213 antibiotic_resistance ARO:3001390 TEM-213 TEM-213 From the Lahey list of beta-lactamases. Not yet released. TEM-214 antibiotic_resistance ARO:3001391 TEM-214 TEM-214 From the Lahey list of beta-lactamases. Not yet released. TEM-215 antibiotic_resistance ARO:3001392 TEM-215 TEM-215 From the Lahey list of beta-lactamases. Not yet released. TEM-216 antibiotic_resistance ARO:3001393 TEM-216 TEM-216 From the Lahey list of beta-lactamases. Not yet released. Isolated from Enterobacter cloacae. TEM-217 antibiotic_resistance ARO:3001394 TEM-217 TEM-217 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3001395 TEM-218 OXA-1 is a beta-lactamase found in E. coli. OXA-1 OXA-30 antibiotic_resistance ARO:3001396 OXA-1 OXA-1 is a beta-lactamase found in E. coli. PMID:2823258 PMID:33416461 OXA-1 OXA-2 is a beta-lactamase found in the Enterobacteriaceae family. OXA-2 antibiotic_resistance ARO:3001397 OXA-2 OXA-2 is a beta-lactamase found in the Enterobacteriaceae family. PMID:27499434 PMID:6335398 OXA-2 OXA-3 is a beta-lactamase found in P. aeruginosa. OXA-3 antibiotic_resistance ARO:3001398 OXA-3 OXA-3 is a beta-lactamase found in P. aeruginosa. PMID:7785990 OXA-3 OXA-4 is a beta-lactamase found in Enterobacteriaceae and P. aeruginosa. OXA-4 antibiotic_resistance ARO:3001399 OXA-4 OXA-4 is a beta-lactamase found in Enterobacteriaceae and P. aeruginosa. PMID:24426128 OXA-4 OXA-5 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae. OXA-5 antibiotic_resistance ARO:3001400 OXA-5 OXA-5 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae. PMID:3925874 OXA-5 OXA-5 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae. antibiotic_resistance ARO:3001401 OXA-6 OXA-5 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae. PMID:3925874 OXA-7 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae. OXA-7 antibiotic_resistance ARO:3001402 OXA-7 OXA-7 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae. PMID:3925874 OXA-7 OXA-8 is an uncharacterized beta-lactamase. antibiotic_resistance ARO:3001403 OXA-8 OXA-9 is a beta-lactamase found in Klebsiella pneumoniae. OXA-9 antibiotic_resistance ARO:3001404 OXA-9 OXA-9 is a beta-lactamase found in Klebsiella pneumoniae. PMID:9620445 OXA-9 OXA-10 is a beta-lactamase found in Acinetobacter baumannii and P. aeruginosa. OXA-10 PSE-2 antibiotic_resistance ARO:3001405 OXA-10 OXA-10 is a beta-lactamase found in Acinetobacter baumannii and P. aeruginosa. PMID:11017203 PMID:27499434 OXA-10 OXA-11 is a beta-lactamase found in P. aeruginosa. OXA-11 antibiotic_resistance ARO:3001406 OXA-11 OXA-11 is a beta-lactamase found in P. aeruginosa. PMID:8215276 OXA-11 OXA-12 is a beta-lactamase found in Aeromonas jandaei. AsbB1 OXA-12 antibiotic_resistance ARO:3001407 OXA-12 OXA-12 is a beta-lactamase found in Aeromonas jandaei. PMID:9068648 OXA-12 OXA-13 is a beta-lactamase found in P. aeruginosa. OXA-13 antibiotic_resistance ARO:3001408 OXA-13 OXA-13 is a beta-lactamase found in P. aeruginosa. PMID:9579076 OXA-13 OXA-14 is a beta-lactamase found in P. aeruginosa. OXA-14 antibiotic_resistance ARO:3001409 OXA-14 OXA-14 is a beta-lactamase found in P. aeruginosa. PMID:7486940 OXA-14 OXA-15 is a beta-lactamase found in P. aeruginosa. OXA-15 antibiotic_resistance ARO:3001410 OXA-15 OXA-15 is a beta-lactamase found in P. aeruginosa. PMID:9087490 OXA-15 OXA-16 is a beta-lactamase found in P. aeruginosa. OXA-16 antibiotic_resistance ARO:3001411 OXA-16 OXA-16 is a beta-lactamase found in P. aeruginosa. PMID:9835501 OXA-16 OXA-17 is a beta-lactamase found in P. aeruginosa and Klebsiella pneumoniae. OXA-17 antibiotic_resistance ARO:3001412 OXA-17 OXA-17 is a beta-lactamase found in P. aeruginosa and Klebsiella pneumoniae. PMID:10348753 OXA-17 OXA-18 is a beta-lactamase found in P. aeruginosa and Rickettsia. OXA-18 antibiotic_resistance ARO:3001413 OXA-18 OXA-18 is a beta-lactamase found in P. aeruginosa and Rickettsia. PMID:9333046 OXA-18 OXA-19 is a beta-lactamase found in P. aeruginosa. OXA-19 intl1 antibiotic_resistance ARO:3001414 OXA-19 OXA-19 is a beta-lactamase found in P. aeruginosa. PMID:9835500 OXA-19 OXA-20 is a beta-lactamase found in P. aeruginosa. OXA-20 antibiotic_resistance ARO:3001415 OXA-20 OXA-20 is a beta-lactamase found in P. aeruginosa. PMID:9687410 OXA-20 OXA-21 is a beta-lactamase found in A. baumannii. OXA-21 antibiotic_resistance ARO:3001416 OXA-21 OXA-21 is a beta-lactamase found in A. baumannii. PMID:9420053 OXA-21 OXA-22 is a beta-lactamase found in Ralstonia pickettii. OXA-22 antibiotic_resistance ARO:3001417 OXA-22 OXA-22 is a beta-lactamase found in Ralstonia pickettii. PMID:10898703 OXA-22 OXA-23 is a beta-lactamase found in A. baumannii. ARI-1 OXA-23 antibiotic_resistance ARO:3001418 OXA-23 OXA-23 is a beta-lactamase found in A. baumannii. PMID:10602749 OXA-23 OXA-24 is a beta-lactamase found in A. baumannii and P. aeruginosa. OXA-24 OXA-40 antibiotic_resistance ARO:3001419 OXA-24 OXA-24 is a beta-lactamase found in A. baumannii and P. aeruginosa. PMID:10817708 PMID:18585868 OXA-24 OXA-25 is a beta-lactamase found in A. baumannii. OXA-25 antibiotic_resistance ARO:3001420 OXA-25 OXA-25 is a beta-lactamase found in A. baumannii. PMID:11158758 OXA-25 OXA-26 is a beta-lactamase found in A. baumannii. OXA-26 antibiotic_resistance ARO:3001421 OXA-26 OXA-26 is a beta-lactamase found in A. baumannii. PMID:11158758 OXA-26 OXA-27 is a beta-lactamase found in A. baumannii. OXA-27 antibiotic_resistance ARO:3001422 OXA-27 OXA-27 is a beta-lactamase found in A. baumannii. PMID:11158758 OXA-27 OXA-28 is a beta-lactamase found in P. aeruginosa. OXA-28 antibiotic_resistance ARO:3001423 OXA-28 OXA-28 is a beta-lactamase found in P. aeruginosa. PMID:11158739 OXA-28 OXA-29 is a beta-lactamase found in Legionella gormanii. OXA-29 antibiotic_resistance ARO:3001424 OXA-29 OXA-29 is a beta-lactamase found in Legionella gormanii. PMID:11709332 OXA-29 OXA-31 is a beta-lactamase found in P. aeruginosa. OXA-31 antibiotic_resistance ARO:3001425 OXA-31 OXA-31 is a beta-lactamase found in P. aeruginosa. PMID:11353602 OXA-31 OXA-32 is a beta-lactamase found in P. aeruginosa. OXA-32 antibiotic_resistance ARO:3001426 OXA-32 OXA-32 is a beta-lactamase found in P. aeruginosa. PMID:11796380 OXA-32 OXA-33 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-33 antibiotic_resistance ARO:3001427 OXA-33 OXA-33 OXA-34 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-34 antibiotic_resistance ARO:3001428 OXA-34 OXA-34 OXA-35 is a beta-lactamase found in P. aeruginosa. OXA-35 antibiotic_resistance ARO:3001429 OXA-35 OXA-35 is a beta-lactamase found in P. aeruginosa. PMID:11679562 OXA-35 OXA-36 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-36 antibiotic_resistance ARO:3001430 OXA-36 OXA-36 OXA-37 is a beta-lactamase found in A. baumannii. OXA-37 antibiotic_resistance ARO:3001431 OXA-37 OXA-37 is a beta-lactamase found in A. baumannii. PMID:12523622 OXA-37 OXA-38 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001432 OXA-38 OXA-39 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001433 OXA-39 OXA-41 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001434 OXA-41 OXA-44 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001435 OXA-44 OXA-52 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001436 OXA-52 OXA-67 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-67 antibiotic_resistance ARO:3001437 OXA-67 OXA-67 OXA-100 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-100 antibiotic_resistance ARO:3001438 OXA-100 OXA-100 OXA-101 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-101 antibiotic_resistance ARO:3001439 OXA-101 OXA-101 OXA-115 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-115 antibiotic_resistance ARO:3001440 OXA-115 OXA-115 OXA-116 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-116 antibiotic_resistance ARO:3001441 OXA-116 OXA-116 OXA-117 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-117 antibiotic_resistance ARO:3001442 OXA-117 OXA-117 OXA-121 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-121 antibiotic_resistance ARO:3001443 OXA-121 OXA-121 OXA-122 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-122 antibiotic_resistance ARO:3001444 OXA-122 OXA-122 OXA-123 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-123 antibiotic_resistance ARO:3001445 OXA-123 OXA-123 OXA-124 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-124 antibiotic_resistance ARO:3001446 OXA-124 OXA-124 OXA-125 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-125 antibiotic_resistance ARO:3001447 OXA-125 OXA-125 OXA-126 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-126 antibiotic_resistance ARO:3001448 OXA-126 OXA-126 OXA-127 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-127 antibiotic_resistance ARO:3001449 OXA-127 OXA-127 OXA-139 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-139 antibiotic_resistance ARO:3001451 OXA-139 OXA-139 OXA-140 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-140 antibiotic_resistance ARO:3001452 OXA-140 OXA-140 OXA-148 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-148 antibiotic_resistance ARO:3001453 OXA-148 OXA-148 OXA-149 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-149 antibiotic_resistance ARO:3001454 OXA-149 OXA-149 OXA-150 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-150 antibiotic_resistance ARO:3001455 OXA-150 OXA-150 OXA-151 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-135 OXA-151 antibiotic_resistance ARO:3001456 OXA-151 OXA-151 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. PMID:26349828 OXA-151 OXA-152 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-152 antibiotic_resistance ARO:3001457 OXA-152 OXA-152 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. PMID:26349828 OXA-152 OXA-153 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-153 antibiotic_resistance ARO:3001458 OXA-153 OXA-153 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. PMID:26349828 OXA-153 OXA-154 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-154 antibiotic_resistance ARO:3001459 OXA-154 OXA-154 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. PMID:26349828 OXA-154 OXA-155 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-155 antibiotic_resistance ARO:3001460 OXA-155 OXA-155 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. PMID:26349828 OXA-155 OXA-156 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-156 antibiotic_resistance ARO:3001461 OXA-156 OXA-156 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. PMID:26349828 OXA-156 OXA-157 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-157 antibiotic_resistance ARO:3001462 OXA-157 OXA-157 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. PMID:26349828 OXA-157 OXA-158 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-158 antibiotic_resistance ARO:3001463 OXA-158 OXA-158 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. PMID:26349828 OXA-158 OXA-159 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-159 antibiotic_resistance ARO:3001464 OXA-159 OXA-159 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. PMID:26349828 OXA-159 OXA-165 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-165 antibiotic_resistance ARO:3001465 OXA-165 OXA-165 OXA-166 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-166 antibiotic_resistance ARO:3001466 OXA-166 OXA-166 OXA-167 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-167 antibiotic_resistance ARO:3001467 OXA-167 OXA-167 OXA-168 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-168 antibiotic_resistance ARO:3001468 OXA-168 OXA-168 OXA-169 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-169 antibiotic_resistance ARO:3001469 OXA-169 OXA-169 OXA-170 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-170 antibiotic_resistance ARO:3001470 OXA-170 OXA-170 OXA-171 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-171 antibiotic_resistance ARO:3001471 OXA-171 OXA-171 OXA-178 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-178 antibiotic_resistance ARO:3001472 OXA-178 OXA-178 OXA-179 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-179 antibiotic_resistance ARO:3001473 OXA-179 OXA-179 OXA-180 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-180 antibiotic_resistance ARO:3001474 OXA-180 OXA-180 OXA-183 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-183 antibiotic_resistance ARO:3001475 OXA-183 OXA-183 OXA-184 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-184 antibiotic_resistance ARO:3001476 OXA-184 OXA-184 OXA-185 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-185 antibiotic_resistance ARO:3001477 OXA-185 OXA-185 OXA-193 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-193 antibiotic_resistance ARO:3001478 OXA-193 OXA-193 OXA-194 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-194 antibiotic_resistance ARO:3001479 OXA-194 OXA-194 OXA-195 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-195 antibiotic_resistance ARO:3001480 OXA-195 OXA-195 OXA-196 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-196 antibiotic_resistance ARO:3001481 OXA-196 OXA-196 OXA-197 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-197 antibiotic_resistance ARO:3001482 OXA-197 OXA-197 OXA-205 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-205 antibiotic_resistance ARO:3001483 OXA-205 OXA-205 OXA-206 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-206 antibiotic_resistance ARO:3001484 OXA-206 OXA-206 OXA-207 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-207 antibiotic_resistance ARO:3001485 OXA-207 OXA-207 OXA-208 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-208 antibiotic_resistance ARO:3001486 OXA-208 OXA-208 OXA-210 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-210 antibiotic_resistance ARO:3001487 OXA-210 OXA-210 OXA-216 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-216 antibiotic_resistance ARO:3001488 OXA-216 OXA-216 OXA-217 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-217 antibiotic_resistance ARO:3001489 OXA-217 OXA-217 OXA-220 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001490 OXA-220 OXA-221 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001491 OXA-221 OXA-222 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001492 OXA-222 OXA-225 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-225 antibiotic_resistance ARO:3001493 OXA-225 OXA-225 OXA-227 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001494 OXA-227 OXA-233 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-233 antibiotic_resistance ARO:3001495 OXA-233 OXA-233 OXA-234 is a beta-lactamase found in Acinetobacter baumannii. OXA-234 antibiotic_resistance ARO:3001496 OXA-234 OXA-234 OXA-238 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001497 OXA-238 OXA-239 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-239 antibiotic_resistance ARO:3001498 OXA-239 OXA-239 OXA-240 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-240 antibiotic_resistance ARO:3001499 OXA-240 OXA-240 OXA-251 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-251 antibiotic_resistance ARO:3001500 OXA-251 OXA-251 OXA-252 is a beta-lactamase found in Shewanella spp. OXA-252 antibiotic_resistance ARO:3001501 OXA-252 OXA-252 OXA-256 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-256 antibiotic_resistance ARO:3001502 OXA-256 OXA-256 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. PMID:23458448 OXA-256 OXA-258 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-258 antibiotic_resistance ARO:3001503 OXA-258 OXA-258 OXA-309 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-309 antibiotic_resistance ARO:3001504 OXA-309 OXA-309 OXA-310 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001505 OXA-310 OXA-311 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001506 OXA-311 OXA-318 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001507 OXA-318 OXA-319 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001508 OXA-319 OXA-321 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001509 OXA-321 OXA-322 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-322 antibiotic_resistance ARO:3001510 OXA-322 OXA-322 OXA-323 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-323 antibiotic_resistance ARO:3001511 OXA-323 OXA-323 OXA-324 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-324 antibiotic_resistance ARO:3001512 OXA-324 OXA-324 OXA-325 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-325 antibiotic_resistance ARO:3001513 OXA-325 OXA-325 OXA-326 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-326 antibiotic_resistance ARO:3001514 OXA-326 OXA-326 OXA-327 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-327 antibiotic_resistance ARO:3001515 OXA-327 OXA-327 OXA-328 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-328 antibiotic_resistance ARO:3001516 OXA-328 OXA-328 OXA-329 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-329 antibiotic_resistance ARO:3001517 OXA-329 OXA-329 OXA-330 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-330 antibiotic_resistance ARO:3001518 OXA-330 OXA-330 OXA-331 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-331 antibiotic_resistance ARO:3001519 OXA-331 OXA-331 OXA-332 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-332 antibiotic_resistance ARO:3001520 OXA-332 OXA-332 OXA-333 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-333 antibiotic_resistance ARO:3001521 OXA-333 OXA-333 OXA-334 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-334 antibiotic_resistance ARO:3001522 OXA-334 OXA-334 OXA-335 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-335 antibiotic_resistance ARO:3001523 OXA-335 OXA-335 OXA-336 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-336 antibiotic_resistance ARO:3001524 OXA-336 OXA-336 OXA-337 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-337 antibiotic_resistance ARO:3001525 OXA-337 OXA-337 OXA-338 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-338 antibiotic_resistance ARO:3001526 OXA-338 OXA-338 OXA-339 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-339 antibiotic_resistance ARO:3001527 OXA-339 OXA-339 OXA-340 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-340 antibiotic_resistance ARO:3001528 OXA-340 OXA-340 OXA-341 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-341 antibiotic_resistance ARO:3001529 OXA-341 OXA-341 OXA-342 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-342 antibiotic_resistance ARO:3001530 OXA-342 OXA-342 OXA-343 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-343 antibiotic_resistance ARO:3001531 OXA-343 OXA-343 OXA-344 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-344 antibiotic_resistance ARO:3001532 OXA-344 OXA-344 OXA-345 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-345 antibiotic_resistance ARO:3001533 OXA-345 OXA-345 OXA-346 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-346 antibiotic_resistance ARO:3001534 OXA-346 OXA-346 OXA-348 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-348 antibiotic_resistance ARO:3001535 OXA-348 OXA-348 OXA-349 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-349 antibiotic_resistance ARO:3001536 OXA-349 OXA-349 OXA-350 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-350 antibiotic_resistance ARO:3001537 OXA-350 OXA-350 OXA-351 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-351 antibiotic_resistance ARO:3001538 OXA-351 OXA-351 OXA-352 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-352 antibiotic_resistance ARO:3001539 OXA-352 OXA-352 OXA-353 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-353 antibiotic_resistance ARO:3001540 OXA-353 OXA-353 OXA-354 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-354 antibiotic_resistance ARO:3001541 OXA-354 OXA-354 OXA-355 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-355 antibiotic_resistance ARO:3001542 OXA-355 OXA-355 OXA-356 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-356 antibiotic_resistance ARO:3001543 OXA-356 OXA-356 OXA-357 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-357 antibiotic_resistance ARO:3001544 OXA-357 OXA-357 OXA-358 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-358 antibiotic_resistance ARO:3001545 OXA-358 OXA-358 OXA-359 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-359 antibiotic_resistance ARO:3001546 OXA-359 OXA-359 OXA-360 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-360 antibiotic_resistance ARO:3001547 OXA-360 OXA-360 OXA-361 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-361 antibiotic_resistance ARO:3001548 OXA-361 OXA-361 OXA-362 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-362 antibiotic_resistance ARO:3001549 OXA-362 OXA-362 OXA-363 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-363 antibiotic_resistance ARO:3001550 OXA-363 OXA-363 OXA-364 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-364 antibiotic_resistance ARO:3001551 OXA-364 OXA-364 OXA-365 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-365 antibiotic_resistance ARO:3001552 OXA-365 OXA-365 OXA-366 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-366 antibiotic_resistance ARO:3001553 OXA-366 OXA-366 OXA-367 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001554 OXA-367 OXA-368 is a beta-lactamase found in Aeromonas sobria. From the Lahey list of OXA beta-lactamases. OXA-368 antibiotic_resistance ARO:3001555 OXA-368 OXA-368 is a beta-lactamase found in Aeromonas sobria. From the Lahey list of OXA beta-lactamases. PMID:27499434 OXA-368 OXA-371 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-371 antibiotic_resistance ARO:3001557 OXA-371 OXA-371 OXA-372 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-372 antibiotic_resistance ARO:3001558 OXA-372 OXA-372 OXA-373 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-373 antibiotic_resistance ARO:3001559 OXA-373 OXA-373 OXA-374 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-374 antibiotic_resistance ARO:3001560 OXA-374 OXA-374 OXA-375 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-375 antibiotic_resistance ARO:3001561 OXA-375 OXA-375 OXA-376 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-376 antibiotic_resistance ARO:3001562 OXA-376 OXA-376 OXA-377 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-377 antibiotic_resistance ARO:3001563 OXA-377 OXA-377 OXA-378 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-378 antibiotic_resistance ARO:3001564 OXA-378 OXA-378 OXA-379 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-379 antibiotic_resistance ARO:3001565 OXA-379 OXA-379 OXA-380 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-380 antibiotic_resistance ARO:3001566 OXA-380 OXA-380 OXA-381 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-381 antibiotic_resistance ARO:3001567 OXA-381 OXA-381 OXA-382 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-382 antibiotic_resistance ARO:3001568 OXA-382 OXA-382 OXA-383 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-383 antibiotic_resistance ARO:3001569 OXA-383 OXA-383 OXA-384 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-384 antibiotic_resistance ARO:3001570 OXA-384 OXA-384 OXA-385 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-385 antibiotic_resistance ARO:3001571 OXA-385 OXA-385 OXA-386 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-386 antibiotic_resistance ARO:3001572 OXA-386 OXA-386 OXA-387 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-387 antibiotic_resistance ARO:3001573 OXA-387 OXA-387 OXA-388 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-388 antibiotic_resistance ARO:3001574 OXA-388 OXA-388 OXA-389 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-389 antibiotic_resistance ARO:3001575 OXA-389 OXA-389 OXA-390 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-390 antibiotic_resistance ARO:3001576 OXA-390 OXA-390 OXA-391 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-391 antibiotic_resistance ARO:3001577 OXA-391 OXA-391 OXA-392 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-392 antibiotic_resistance ARO:3001578 OXA-392 OXA-392 OXA-393 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001579 OXA-393 OXA-394 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001580 OXA-394 OXA-395 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-395 antibiotic_resistance ARO:3001581 OXA-395 OXA-395 OXA-396 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-396 antibiotic_resistance ARO:3001582 OXA-396 OXA-396 OXA-397 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-397 antibiotic_resistance ARO:3001583 OXA-397 OXA-397 OXA-398 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-398 antibiotic_resistance ARO:3001584 OXA-398 OXA-398 OXA-399 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001585 OXA-399 OXA-400 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-400 antibiotic_resistance ARO:3001586 OXA-400 OXA-400 OXA-401 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-401 antibiotic_resistance ARO:3001587 OXA-401 OXA-401 OXA-402 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-402 antibiotic_resistance ARO:3001588 OXA-402 OXA-402 OXA-403 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-403 antibiotic_resistance ARO:3001589 OXA-403 OXA-403 OXA-404 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-404 antibiotic_resistance ARO:3001595 OXA-404 OXA-404 OXA-405 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-405 antibiotic_resistance ARO:3001596 OXA-405 OXA-405 OXA-406 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-406 antibiotic_resistance ARO:3001597 OXA-406 OXA-406 OXA-407 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-407 antibiotic_resistance ARO:3001598 OXA-407 OXA-407 OXA-408 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-408 antibiotic_resistance ARO:3001599 OXA-408 OXA-408 OXA-409 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-409 antibiotic_resistance ARO:3001600 OXA-409 OXA-409 OXA-410 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. antibiotic_resistance ARO:3001601 OXA-410 OXA-411 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-411 antibiotic_resistance ARO:3001602 OXA-411 OXA-411 OXA-412 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-412 antibiotic_resistance ARO:3001603 OXA-412 OXA-412 OXA-413 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-413 antibiotic_resistance ARO:3001604 OXA-413 OXA-413 OXA-414 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-414 antibiotic_resistance ARO:3001605 OXA-414 OXA-414 OXA-415 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-415 antibiotic_resistance ARO:3001606 OXA-415 OXA-415 OXA-416 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-416 antibiotic_resistance ARO:3001607 OXA-416 OXA-416 OXA-417 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-417 antibiotic_resistance ARO:3001608 OXA-417 OXA-417 OXA-114a is a beta-lactamase found in Achromobacter xylosoxidans. OXA-114a antibiotic_resistance ARO:3001609 OXA-114a OXA-114a is a beta-lactamase found in Achromobacter xylosoxidans. PMID:18362192 OXA-114a OXA-243 is a beta-lactamase found in Achromobacter xylosoxidans. OXA-243 antibiotic_resistance ARO:3001610 OXA-243 OXA-243 is a beta-lactamase found in Achromobacter xylosoxidans. PMID:22944724 OXA-243 OXA-58 is a beta-lactamase found in A. baumannii. OXA-58 antibiotic_resistance ARO:3001611 OXA-58 OXA-58 is a beta-lactamase found in A. baumannii. PMID:15616297 OXA-58 OXA-51 is a beta-lactamase found in A. baumannii. OXA-51 antibiotic_resistance ARO:3001612 OXA-51 OXA-51 is a beta-lactamase found in A. baumannii. PMID:15649299 OXA-51 OXA-64 is a beta-lactamase found in A. baumannii. OXA-64 antibiotic_resistance ARO:3001613 OXA-64 OXA-64 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-64 OXA-65 is a beta-lactamase found in A. baumannii. OXA-65 antibiotic_resistance ARO:3001614 OXA-65 OXA-65 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-65 OXA-66 is a beta-lactamase found in A. baumannii. OXA-66 antibiotic_resistance ARO:3001615 OXA-66 OXA-66 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-66 OXA-68 is a beta-lactamase found in A. baumannii. OXA-68 antibiotic_resistance ARO:3001616 OXA-68 OXA-68 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-68 OXA-69 is a beta-lactamase found in A. baumannii. OXA-69 antibiotic_resistance ARO:3001617 OXA-69 OXA-69 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-69 OXA-70 is a beta-lactamase found in A. baumannii. OXA-70 antibiotic_resistance ARO:3001618 OXA-70 OXA-70 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-70 OXA-71 is a beta-lactamase found in A. baumannii. OXA-71 antibiotic_resistance ARO:3001619 OXA-71 OXA-71 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-71 OXA-75 is a beta-lactamase found in A. baumannii. OXA-75 antibiotic_resistance ARO:3001620 OXA-75 OXA-75 is a beta-lactamase found in A. baumannii. PMID:16189095 OXA-75 OXA-76 is a beta-lactamase found in A. baumannii. OXA-76 antibiotic_resistance ARO:3001621 OXA-76 OXA-76 is a beta-lactamase found in A. baumannii. PMID:16189095 OXA-76 OXA-77 is a beta-lactamase found in A. baumannii. OXA-77 antibiotic_resistance ARO:3001622 OXA-77 OXA-77 is a beta-lactamase found in A. baumannii. PMID:16189095 OXA-77 OXA-83 is a beta-lactamase found in A. baumannii. OXA-83 antibiotic_resistance ARO:3001623 OXA-83 OXA-83 is a beta-lactamase found in A. baumannii. PMID:16630258 OXA-83 OXA-84 is a beta-lactamase found in A. baumannii. OXA-84 antibiotic_resistance ARO:3001624 OXA-84 OXA-84 is a beta-lactamase found in A. baumannii. PMID:16630258 OXA-84 OXA-89 is a beta-lactamase found in A. baumannii. OXA-89 antibiotic_resistance ARO:3001625 OXA-89 OXA-89 is a beta-lactamase found in A. baumannii. PMID:16844350 OXA-89 OXA-88 is a beta-lactamase found in A. baumannii. OXA-88 antibiotic_resistance ARO:3001626 OXA-88 OXA-88 is a beta-lactamase found in A. baumannii. PMID:17284537 OXA-88 OXA-91 is a beta-lactamase found in A. baumannii. OXA-91 antibiotic_resistance ARO:3001627 OXA-91 OXA-91 is a beta-lactamase found in A. baumannii. PMID:17284537 OXA-91 OXA-93 is a beta-lactamase found in A. baumannii. OXA-93 antibiotic_resistance ARO:3001628 OXA-93 OXA-93 is a beta-lactamase found in A. baumannii. PMID:17284537 OXA-93 OXA-94 is a beta-lactamase found in A. baumannii. OXA-94 antibiotic_resistance ARO:3001629 OXA-94 OXA-94 is a beta-lactamase found in A. baumannii. PMID:17284537 OXA-94 OXA-95 is a beta-lactamase found in A. baumannii. OXA-95 antibiotic_resistance ARO:3001630 OXA-95 OXA-95 is a beta-lactamase found in A. baumannii. PMID:17284537 OXA-95 OXA-96 is a beta-lactamase found in A. baumannii. OXA-96 antibiotic_resistance ARO:3001631 OXA-96 OXA-96 is a beta-lactamase found in A. baumannii. PMID:17284537 OXA-96 OXA-92 is a beta-lactamase found in A. baumannii. OXA-92 antibiotic_resistance ARO:3001632 OXA-92 OXA-92 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-92 OXA-79 is a beta-lactamase found in A. baumannii. OXA-79 antibiotic_resistance ARO:3001633 OXA-79 OXA-79 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-79 OXA-80 is a beta-lactamase found in A. baumannii. OXA-80 antibiotic_resistance ARO:3001634 OXA-80 OXA-80 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-80 OXA-82 is a beta-lactamase found in A. baumannii. OXA-82 antibiotic_resistance ARO:3001635 OXA-82 OXA-82 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-82 OXA-104 is a beta-lactamase found in A. baumannii. OXA-104 antibiotic_resistance ARO:3001636 OXA-104 OXA-104 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-104 OXA-106 is a beta-lactamase found in A. baumannii. OXA-106 antibiotic_resistance ARO:3001637 OXA-106 OXA-106 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-106 OXA-107 is a beta-lactamase found in A. baumannii. OXA-107 antibiotic_resistance ARO:3001638 OXA-107 OXA-107 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-107 OXA-108 is a beta-lactamase found in A. baumannii. OXA-108 antibiotic_resistance ARO:3001639 OXA-108 OXA-108 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-108 OXA-109 is a beta-lactamase found in A. baumannii. OXA-109 antibiotic_resistance ARO:3001640 OXA-109 OXA-109 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-109 OXA-110 is a beta-lactamase found in A. baumannii. OXA-110 antibiotic_resistance ARO:3001641 OXA-110 OXA-110 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-110 OXA-111 is a beta-lactamase found in A. baumannii. OXA-111 antibiotic_resistance ARO:3001642 OXA-111 OXA-111 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-111 OXA-112 is a beta-lactamase found in A. baumannii. OXA-112 antibiotic_resistance ARO:3001643 OXA-112 OXA-112 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-112 OXA-113 is a beta-lactamase found in A. baumannii. OXA-113 antibiotic_resistance ARO:3001644 OXA-113 OXA-113 is a beta-lactamase found in A. baumannii. PMID:17881631 OXA-113 OXA-78 is a beta-lactamase found in A. baumannii. OXA-78 antibiotic_resistance ARO:3001645 OXA-78 OXA-78 is a beta-lactamase found in A. baumannii. PMID:18190566 OXA-78 OXA-98 is a beta-lactamase found in A. baumannii. OXA-98 antibiotic_resistance ARO:3001646 OXA-98 OXA-98 is a beta-lactamase found in A. baumannii. PMID:18190566 OXA-98 OXA-97 is a beta-lactamase found in A. baumannii. OXA-97 antibiotic_resistance ARO:3001647 OXA-97 OXA-97 is a beta-lactamase found in A. baumannii. PMID:18299404 OXA-97 OXA-128 is a beta-lactamase found in A. baumannii. OXA-128 antibiotic_resistance ARO:3001648 OXA-128 OXA-128 is a beta-lactamase found in A. baumannii. PMID:19223304 OXA-128 OXA-99 is a beta-lactamase found in A. baumannii. OXA-99 antibiotic_resistance ARO:3001649 OXA-99 OXA-99 is a beta-lactamase found in A. baumannii. PMID:19394202 OXA-99 OXA-90 is a beta-lactamase found in A. baumannii. OXA-90 antibiotic_resistance ARO:3001650 OXA-90 OXA-90 is a beta-lactamase found in A. baumannii. PMID:19567349 OXA-90 OXA-130 is a beta-lactamase found in A. baumannii. OXA-130 antibiotic_resistance ARO:3001651 OXA-130 OXA-130 is a beta-lactamase found in A. baumannii. PMID:19567349 OXA-130 OXA-131 is a beta-lactamase found in A. baumannii. OXA-131 antibiotic_resistance ARO:3001652 OXA-131 OXA-131 is a beta-lactamase found in A. baumannii. PMID:19567349 OXA-131 OXA-132 is a beta-lactamase found in A. baumannii. OXA-132 antibiotic_resistance ARO:3001653 OXA-132 OXA-132 is a beta-lactamase found in A. baumannii. PMID:19567349 OXA-132 OXA-143 is a beta-lactamase found in A. baumannii. OXA-143 antibiotic_resistance ARO:3001654 OXA-143 OXA-143 is a beta-lactamase found in A. baumannii. PMID:19770279 OXA-143 OXA-138 is a beta-lactamase found in A. baumannii. OXA-138 antibiotic_resistance ARO:3001655 OXA-138 OXA-138 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-138 OXA-172 is a beta-lactamase found in A. baumannii. OXA-172 antibiotic_resistance ARO:3001656 OXA-172 OXA-172 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-172 OXA-173 is a beta-lactamase found in A. baumannii. OXA-173 antibiotic_resistance ARO:3001657 OXA-173 OXA-173 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-173 OXA-174 is a beta-lactamase found in A. baumannii. OXA-174 antibiotic_resistance ARO:3001658 OXA-174 OXA-174 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-174 OXA-175 is a beta-lactamase found in A. baumannii. OXA-175 antibiotic_resistance ARO:3001659 OXA-175 OXA-175 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-175 OXA-176 is a beta-lactamase found in A. baumannii. OXA-176 antibiotic_resistance ARO:3001660 OXA-176 OXA-176 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-176 OXA-177 is a beta-lactamase found in A. baumannii. OXA-177 antibiotic_resistance ARO:3001661 OXA-177 OXA-177 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-177 OXA-164 is a beta-lactamase found in A. baumannii. OXA-164 antibiotic_resistance ARO:3001662 OXA-164 OXA-164 is a beta-lactamase found in A. baumannii. PMID:20921306 OXA-164 OXA-160 is a beta-lactamase found in A. baumannii. OXA-160 antibiotic_resistance ARO:3001663 OXA-160 OXA-160 is a beta-lactamase found in A. baumannii. PMID:21041501 OXA-160 OXA-203 is a beta-lactamase found in A. baumannii. OXA-203 antibiotic_resistance ARO:3001664 OXA-203 OXA-203 is a beta-lactamase found in A. baumannii. PMID:21289143 OXA-203 OXA-200 is a beta-lactamase found in A. baumannii. OXA-200 antibiotic_resistance ARO:3001665 OXA-200 OXA-200 is a beta-lactamase found in A. baumannii. PMID:22422849 OXA-200 OXA-201 is a beta-lactamase found in A. baumannii. OXA-201 antibiotic_resistance ARO:3001666 OXA-201 OXA-201 is a beta-lactamase found in A. baumannii. PMID:22422849 OXA-201 OXA-202 is a beta-lactamase found in A. baumannii. OXA-202 antibiotic_resistance ARO:3001667 OXA-202 OXA-202 is a beta-lactamase found in A. baumannii. PMID:22422849 OXA-202 OXA-219 is a beta-lactamase found in A. baumannii. OXA-219 antibiotic_resistance ARO:3001668 OXA-219 OXA-219 is a beta-lactamase found in A. baumannii. PMID:22422849 OXA-219 OXA-223 is a beta-lactamase found in A. baumannii. OXA-223 antibiotic_resistance ARO:3001669 OXA-223 OXA-223 is a beta-lactamase found in A. baumannii. PMID:22422849 OXA-223 OXA-231 is a beta-lactamase found in A. baumannii. OXA-231 antibiotic_resistance ARO:3001670 OXA-231 OXA-231 is a beta-lactamase found in A. baumannii. PMID:22736746 OXA-231 OXA-49 is a beta-lactamase found in A. baumannii. OXA-49 antibiotic_resistance ARO:3001671 OXA-49 OXA-49 is a beta-lactamase found in A. baumannii. PMID:22842601 OXA-49 OXA-120 is a beta-lactamase found in A. baumannii. OXA-120 antibiotic_resistance ARO:3001672 OXA-120 OXA-120 is a beta-lactamase found in A. baumannii. PMID:22972816 OXA-120 OXA-248 is a beta-lactamase found in A. baumannii. OXA-248 antibiotic_resistance ARO:3001673 OXA-248 OXA-248 is a beta-lactamase found in A. baumannii. PMID:22972816 OXA-248 OXA-249 is a beta-lactamase found in A. baumannii. OXA-249 antibiotic_resistance ARO:3001674 OXA-249 OXA-249 is a beta-lactamase found in A. baumannii. PMID:22972816 OXA-249 OXA-250 is a beta-lactamase found in A. baumannii. OXA-250 antibiotic_resistance ARO:3001675 OXA-250 OXA-250 is a beta-lactamase found in A. baumannii. PMID:22972816 OXA-250 OXA-235 is a beta-lactamase found in A. baumannii. OXA-235 antibiotic_resistance ARO:3001676 OXA-235 OXA-235 is a beta-lactamase found in A. baumannii. PMID:23439638 OXA-235 OXA-236 is a beta-lactamase found in A. baumannii. OXA-236 antibiotic_resistance ARO:3001677 OXA-236 OXA-236 is a beta-lactamase found in A. baumannii. PMID:23439638 OXA-236 OXA-237 is a beta-lactamase found in A. baumannii. OXA-237 antibiotic_resistance ARO:3001678 OXA-237 OXA-237 is a beta-lactamase found in A. baumannii. PMID:23439638 OXA-237 OXA-241 is a beta-lactamase found in A. baumannii. OXA-241 antibiotic_resistance ARO:3001679 OXA-241 OXA-241 is a beta-lactamase found in A. baumannii. PMID:23439638 OXA-241 OXA-242 is a beta-lactamase found in A. baumannii. OXA-242 antibiotic_resistance ARO:3001680 OXA-242 OXA-242 is a beta-lactamase found in A. baumannii. PMID:23439638 OXA-242 OXA-278 is a beta-lactamase found in A. baumannii. OXA-278 antibiotic_resistance ARO:3001681 OXA-278 OXA-278 is a beta-lactamase found in A. baumannii. PMID:23554204 OXA-278 OXA-254 is a beta-lactamase found in A. baumannii. OXA-254 antibiotic_resistance ARO:3001682 OXA-254 OXA-254 is a beta-lactamase found in A. baumannii. PMID:23719027 OXA-254 OXA-312 is a beta-lactamase found in A. baumannii. OXA-312 antibiotic_resistance ARO:3001683 OXA-312 OXA-312 is a beta-lactamase found in A. baumannii. PMID:24247131 OXA-312 OXA-313 is a beta-lactamase found in A. baumannii. OXA-313 antibiotic_resistance ARO:3001684 OXA-313 OXA-313 is a beta-lactamase found in A. baumannii. PMID:24247131 OXA-313 OXA-314 is a beta-lactamase found in A. baumannii. OXA-314 antibiotic_resistance ARO:3001685 OXA-314 OXA-314 is a beta-lactamase found in A. baumannii. PMID:24247131 OXA-314 OXA-315 is a beta-lactamase found in A. baumannii. OXA-315 antibiotic_resistance ARO:3001686 OXA-315 OXA-315 is a beta-lactamase found in A. baumannii. PMID:24247131 OXA-315 OXA-316 is a beta-lactamase found in A. baumannii. OXA-316 antibiotic_resistance ARO:3001687 OXA-316 OXA-316 is a beta-lactamase found in A. baumannii. PMID:24247131 OXA-316 OXA-317 is a beta-lactamase found in A. baumannii. OXA-317 antibiotic_resistance ARO:3001688 OXA-317 OXA-317 is a beta-lactamase found in A. baumannii. PMID:24247131 OXA-317 OXA-253 is a beta-lactamase found in A. baumannii. OXA-253 antibiotic_resistance ARO:3001689 OXA-253 OXA-253 is a beta-lactamase found in A. baumannii. PMID:24566181 OXA-253 OXA-255 is a beta-lactamase found in A. baumannii. OXA-255 antibiotic_resistance ARO:3001690 OXA-255 OXA-255 is a beta-lactamase found in A. baumannii. PMID:24566181 OXA-255 OXA-228 is a beta-lactamase found in A. bereziniae. OXA-228 antibiotic_resistance ARO:3001691 OXA-228 OXA-228 is a beta-lactamase found in A. bereziniae. PMID:22508298 OXA-228 OXA-229 is a beta-lactamase found in A. bereziniae. OXA-229 antibiotic_resistance ARO:3001692 OXA-229 OXA-229 is a beta-lactamase found in A. bereziniae. PMID:22508298 OXA-229 OXA-230 is a beta-lactamase found in A. bereziniae. OXA-230 antibiotic_resistance ARO:3001693 OXA-230 OXA-230 is a beta-lactamase found in A. bereziniae. PMID:22508298 OXA-230 OXA-257 is a beta-lactamase found in A. bereziniae. OXA-257 antibiotic_resistance ARO:3001694 OXA-257 OXA-257 is a beta-lactamase found in A. bereziniae. PMID:23934740 OXA-257 OXA-134 is a beta-lactamase found in A. lwoffii. OXA-134 antibiotic_resistance ARO:3001695 OXA-134 OXA-134 is a beta-lactamase found in A. lwoffii. PMID:20837764 OXA-134 OXA-186 is a beta-lactamase found in A. lwoffii. antibiotic_resistance ARO:3001696 OXA-186 OXA-186 is a beta-lactamase found in A. lwoffii. PMID:20837764 OXA-187 is a beta-lactamase found in A. lwoffii. antibiotic_resistance ARO:3001697 OXA-187 OXA-187 is a beta-lactamase found in A. lwoffii. PMID:20837764 OXA-188 is a beta-lactamase found in A. lwoffii. antibiotic_resistance ARO:3001698 OXA-188 OXA-188 is a beta-lactamase found in A. lwoffii. PMID:20837764 OXA-189 is a beta-lactamase found in A. lwoffii. antibiotic_resistance ARO:3001699 OXA-189 OXA-189 is a beta-lactamase found in A. lwoffii. PMID:20837764 OXA-190 is a beta-lactamase found in A. lwoffii. antibiotic_resistance ARO:3001700 OXA-190 OXA-190 is a beta-lactamase found in A. lwoffii. PMID:20837764 OXA-191 is a beta-lactamase found in A. lwoffii. antibiotic_resistance ARO:3001701 OXA-191 OXA-191 is a beta-lactamase found in A. lwoffii. PMID:20837764 OXA-133 is a beta-lactamase found in A. radioresistens. OXA-133 antibiotic_resistance ARO:3001702 OXA-133 OXA-133 is a beta-lactamase found in A. radioresistens. PMID:19015330 OXA-133 OXA-86 is a beta-lactamase found in Acinetobacter spp. OXA-86 antibiotic_resistance ARO:3001703 OXA-86 OXA-86 is a beta-lactamase found in Acinetobacter spp. PMID:16816400 OXA-86 OXA-87 is a beta-lactamase found in Acinetobacter spp. OXA-87 antibiotic_resistance ARO:3001704 OXA-87 OXA-87 is a beta-lactamase found in Acinetobacter spp. PMID:16816400 OXA-87 OXA-72 is a beta-lactamase found in Acinetobacter spp. OXA-72 antibiotic_resistance ARO:3001705 OXA-72 OXA-72 is a beta-lactamase found in Acinetobacter spp. PMID:17846127 OXA-72 OXA-102 is a beta-lactamase found in Acinetobacter spp. antibiotic_resistance ARO:3001706 OXA-102 OXA-102 is a beta-lactamase found in Acinetobacter spp. PMID:18195058 OXA-103 is a beta-lactamase found in Acinetobacter spp. OXA-103 antibiotic_resistance ARO:3001707 OXA-103 OXA-103 is a beta-lactamase found in Acinetobacter spp. PMID:18195058 OXA-103 OXA-105 is a beta-lactamase found in Acinetobacter spp. OXA-105 antibiotic_resistance ARO:3001708 OXA-105 OXA-105 is a beta-lactamase found in Acinetobacter spp. PMID:18195058 OXA-105 OXA-182 is a beta-lactamase found in Acinetobacter spp. OXA-182 antibiotic_resistance ARO:3001709 OXA-182 OXA-182 is a beta-lactamase found in Acinetobacter spp. PMID:20884158 OXA-182 OXA-211 is a beta-lactamase found in Acinetobacter spp. OXA-211 antibiotic_resistance ARO:3001710 OXA-211 OXA-211 is a beta-lactamase found in Acinetobacter spp. PMID:22128805 OXA-211 OXA-212 is a beta-lactamase found in Acinetobacter spp. OXA-212 antibiotic_resistance ARO:3001711 OXA-212 OXA-212 is a beta-lactamase found in Acinetobacter spp. PMID:22128805 OXA-212 OXA-213 is a beta-lactamase found in Acinetobacter spp. OXA-213 antibiotic_resistance ARO:3001712 OXA-213 OXA-213 is a beta-lactamase found in Acinetobacter spp. PMID:22128805 OXA-213 OXA-214 is a beta-lactamase found in Acinetobacter spp. OXA-214 antibiotic_resistance ARO:3001713 OXA-214 OXA-214 is a beta-lactamase found in Acinetobacter spp. PMID:22128805 OXA-214 OXA-215 is a beta-lactamase found in Acinetobacter spp. OXA-215 antibiotic_resistance ARO:3001714 OXA-215 OXA-215 is a beta-lactamase found in Acinetobacter spp. PMID:22128805 OXA-215 OXA-259 is a beta-lactamase found in Acinetobacter spp. OXA-259 antibiotic_resistance ARO:3001715 OXA-259 OXA-259 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-259 OXA-260 is a beta-lactamase found in Acinetobacter spp. OXA-260 antibiotic_resistance ARO:3001716 OXA-260 OXA-260 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-260 OXA-261 is a beta-lactamase found in Acinetobacter spp. OXA-261 antibiotic_resistance ARO:3001717 OXA-261 OXA-261 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-261 OXA-262 is a beta-lactamase found in Acinetobacter spp. OXA-262 antibiotic_resistance ARO:3001718 OXA-262 OXA-262 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-262 OXA-263 is a beta-lactamase found in Acinetobacter spp. OXA-263 antibiotic_resistance ARO:3001719 OXA-263 OXA-263 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-263 OXA-264 is a beta-lactamase found in Acinetobacter spp. OXA-264 antibiotic_resistance ARO:3001720 OXA-264 OXA-264 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-264 OXA-265 is a beta-lactamase found in Acinetobacter spp. OXA-265 antibiotic_resistance ARO:3001721 OXA-265 OXA-265 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-265 OXA-266 is a beta-lactamase found in Acinetobacter spp. OXA-266 antibiotic_resistance ARO:3001722 OXA-266 OXA-266 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-266 OXA-267 is a beta-lactamase found in Acinetobacter spp. OXA-267 antibiotic_resistance ARO:3001723 OXA-267 OXA-267 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-267 OXA-268 is a beta-lactamase found in Acinetobacter spp. OXA-268 antibiotic_resistance ARO:3001724 OXA-268 OXA-268 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-268 OXA-269 is a beta-lactamase found in Acinetobacter spp. OXA-269 antibiotic_resistance ARO:3001725 OXA-269 OXA-269 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-269 OXA-270 is a beta-lactamase found in Acinetobacter spp. OXA-270 antibiotic_resistance ARO:3001726 OXA-270 OXA-270 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-270 OXA-271 is a beta-lactamase found in Acinetobacter spp. OXA-271 antibiotic_resistance ARO:3001727 OXA-271 OXA-271 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-271 OXA-272 is a beta-lactamase found in Acinetobacter spp. OXA-272 antibiotic_resistance ARO:3001728 OXA-272 OXA-272 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-272 OXA-273 is a beta-lactamase found in Acinetobacter spp. OXA-273 antibiotic_resistance ARO:3001729 OXA-273 OXA-273 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-273 OXA-274 is a beta-lactamase found in Acinetobacter spp. OXA-274 antibiotic_resistance ARO:3001730 OXA-274 OXA-274 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 PMID:30247543 OXA-274 OXA-275 is a beta-lactamase found in Acinetobacter spp. OXA-275 antibiotic_resistance ARO:3001731 OXA-275 OXA-275 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-275 OXA-276 is a beta-lactamase found in Acinetobacter spp. OXA-276 antibiotic_resistance ARO:3001732 OXA-276 OXA-276 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-276 OXA-277 is a beta-lactamase found in Acinetobacter spp. OXA-277 antibiotic_resistance ARO:3001733 OXA-277 OXA-277 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-277 OXA-279 is a beta-lactamase found in Acinetobacter spp. OXA-279 antibiotic_resistance ARO:3001734 OXA-279 OXA-279 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-279 OXA-280 is a beta-lactamase found in Acinetobacter spp. OXA-280 antibiotic_resistance ARO:3001735 OXA-280 OXA-280 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-280 OXA-281 is a beta-lactamase found in Acinetobacter spp. OXA-281 antibiotic_resistance ARO:3001736 OXA-281 OXA-281 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-281 OXA-282 is a beta-lactamase found in Acinetobacter spp. OXA-282 antibiotic_resistance ARO:3001737 OXA-282 OXA-282 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-282 OXA-283 is a beta-lactamase found in Acinetobacter spp. OXA-283 antibiotic_resistance ARO:3001738 OXA-283 OXA-283 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-283 OXA-284 is a beta-lactamase found in Acinetobacter spp. OXA-284 antibiotic_resistance ARO:3001739 OXA-284 OXA-284 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-284 OXA-285 is a beta-lactamase found in Acinetobacter spp. OXA-285 antibiotic_resistance ARO:3001740 OXA-285 OXA-285 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-285 OXA-286 is a beta-lactamase found in Acinetobacter spp. OXA-286 antibiotic_resistance ARO:3001741 OXA-286 OXA-286 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 PMID:30247543 OXA-286 OXA-287 is a beta-lactamase found in Acinetobacter spp. OXA-287 antibiotic_resistance ARO:3001742 OXA-287 OXA-287 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-287 OXA-288 is a beta-lactamase found in Acinetobacter spp. OXA-288 antibiotic_resistance ARO:3001743 OXA-288 OXA-288 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-288 OXA-289 is a beta-lactamase found in Acinetobacter spp. OXA-289 antibiotic_resistance ARO:3001744 OXA-289 OXA-289 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-289 OXA-290 is a beta-lactamase found in Acinetobacter spp. OXA-290 antibiotic_resistance ARO:3001745 OXA-290 OXA-290 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-290 OXA-291 is a beta-lactamase found in Acinetobacter spp. OXA-291 antibiotic_resistance ARO:3001746 OXA-291 OXA-291 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-291 OXA-292 is a beta-lactamase found in Acinetobacter spp. OXA-292 antibiotic_resistance ARO:3001747 OXA-292 OXA-292 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-292 OXA-293 is a beta-lactamase found in Acinetobacter spp. OXA-293 antibiotic_resistance ARO:3001748 OXA-293 OXA-293 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-293 OXA-294 is a beta-lactamase found in Acinetobacter spp. OXA-294 antibiotic_resistance ARO:3001749 OXA-294 OXA-294 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-294 OXA-295 is a beta-lactamase found in Acinetobacter spp. OXA-295 antibiotic_resistance ARO:3001750 OXA-295 OXA-295 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-295 OXA-296 is a beta-lactamase found in Acinetobacter spp. OXA-296 antibiotic_resistance ARO:3001751 OXA-296 OXA-296 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 PMID:30247543 OXA-296 OXA-297 is a beta-lactamase found in Acinetobacter spp. OXA-297 antibiotic_resistance ARO:3001752 OXA-297 OXA-297 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-297 OXA-298 is a beta-lactamase found in Acinetobacter spp. OXA-298 antibiotic_resistance ARO:3001753 OXA-298 OXA-298 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-298 OXA-299 is a beta-lactamase found in Acinetobacter spp. OXA-299 antibiotic_resistance ARO:3001754 OXA-299 OXA-299 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-299 OXA-300 is a beta-lactamase found in Acinetobacter spp. OXA-300 antibiotic_resistance ARO:3001755 OXA-300 OXA-300 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-300 OXA-301 is a beta-lactamase found in Acinetobacter spp. OXA-301 antibiotic_resistance ARO:3001756 OXA-301 OXA-301 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-301 OXA-302 is a beta-lactamase found in Acinetobacter spp. OXA-302 antibiotic_resistance ARO:3001757 OXA-302 OXA-302 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-302 OXA-303 is a beta-lactamase found in Acinetobacter spp. OXA-303 antibiotic_resistance ARO:3001758 OXA-303 OXA-303 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-303 OXA-304 is a beta-lactamase found in Acinetobacter spp. OXA-304 antibiotic_resistance ARO:3001759 OXA-304 OXA-304 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-304 OXA-305 is a beta-lactamase found in Acinetobacter spp. OXA-305 antibiotic_resistance ARO:3001760 OXA-305 OXA-305 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-305 OXA-306 is a beta-lactamase found in Acinetobacter spp. OXA-306 antibiotic_resistance ARO:3001761 OXA-306 OXA-306 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-306 OXA-307 is a beta-lactamase found in Acinetobacter spp. OXA-307 antibiotic_resistance ARO:3001762 OXA-307 OXA-307 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-307 OXA-308 is a beta-lactamase found in Acinetobacter spp. OXA-308 antibiotic_resistance ARO:3001763 OXA-308 OXA-308 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-308 OXA-63 is a beta-lactamase found in Brachyspira spp. OXA-63 antibiotic_resistance ARO:3001764 OXA-63 OXA-63 is a beta-lactamase found in Brachyspira spp. PMID:18212108 OXA-63 OXA-136 is a beta-lactamase found in Brachyspira spp. OXA-136 antibiotic_resistance ARO:3001765 OXA-136 OXA-136 is a beta-lactamase found in Brachyspira spp. PMID:18719182 OXA-136 OXA-192 is a beta-lactamase found in Brachyspira spp. OXA-192 antibiotic_resistance ARO:3001766 OXA-192 OXA-192 is a beta-lactamase found in Brachyspira spp. PMID:21812718 OXA-192 OXA-137 is a beta-lactamase found in Brachyspira spp. OXA-137 antibiotic_resistance ARO:3001767 OXA-137 OXA-137 is a beta-lactamase found in Brachyspira spp. PMID:18719182 OXA-137 OXA-118 is a beta-lactamase found in Burkholderia cepacia. OXA-118 antibiotic_resistance ARO:3001768 OXA-118 OXA-118 is a beta-lactamase found in Burkholderia cepacia. PMID:11972706 OXA-118 OXA-42 is a beta-lactamase found in Burkholderia pseudomallei. OXA-42 antibiotic_resistance ARO:3001769 OXA-42 OXA-42 is a beta-lactamase found in Burkholderia pseudomallei. PMID:12356787 OXA-42 OXA-43 is a beta-lactamase found in Burkholderia pseudomallei. OXA-43 antibiotic_resistance ARO:3001770 OXA-43 OXA-43 is a beta-lactamase found in Burkholderia pseudomallei. PMID:12356787 OXA-43 OXA-57 is a beta-lactamase found in Burkholderia pseudomallei. OXA-57 antibiotic_resistance ARO:3001771 OXA-57 OXA-57 is a beta-lactamase found in Burkholderia pseudomallei. PMID:15793160 OXA-57 OXA-59 is a beta-lactamase found in Burkholderia pseudomallei. OXA-59 antibiotic_resistance ARO:3001772 OXA-59 OXA-59 is a beta-lactamase found in Burkholderia pseudomallei. PMID:15793160 OXA-59 OXA-61 is a beta-lactamase found in Campylobacter jejuni. OXA-61 antibiotic_resistance ARO:3001773 OXA-61 OXA-61 is a beta-lactamase found in Campylobacter jejuni. PMID:15917560 OXA-61 OXA-370 is a beta-lactamase found in Enterobacter hormaechei. OXA-370 antibiotic_resistance ARO:3001774 OXA-370 OXA-370 OXA-119 is a beta-lactamase found in Enterobacteriaceae. OXA-119 antibiotic_resistance ARO:3001775 OXA-119 OXA-119 is a beta-lactamase found in Enterobacteriaceae. PMID:19719593 OXA-119 OXA-162 is a beta-lactamase found in Enterobacteriaceae. OXA-162 antibiotic_resistance ARO:3001776 OXA-162 OXA-162 is a beta-lactamase found in Enterobacteriaceae. PMID:22290940 OXA-162 OXA-347 is a beta-lactamase found in Enterobacteriaceae. OXA-347 antibiotic_resistance ARO:3001777 OXA-347 OXA-347 is a beta-lactamase found in Enterobacteriaceae. PMID:22845886 OXA-347 OXA-232 is a beta-lactamase found in Enterobacteriaceae. OXA-232 antibiotic_resistance ARO:3001778 OXA-232 OXA-232 is a beta-lactamase found in Enterobacteriaceae. PMID:23305656 OXA-232 OXA-146 is a beta-lactamase found in Enterobacteriaceae. OXA-146 antibiotic_resistance ARO:3001779 OXA-146 OXA-146 is a beta-lactamase found in Enterobacteriaceae. PMID:23877677 OXA-146 OXA-85 is a beta-lactamase found in Fusobacterium nucleatum. OXA-85 antibiotic_resistance ARO:3001780 OXA-85 OXA-85 is a beta-lactamase found in Fusobacterium nucleatum. PMID:16870757 OXA-85 OXA-47 is a beta-lactamase found in Klebsiella pneumoniae. OXA-47 antibiotic_resistance ARO:3001781 OXA-47 OXA-47 is a beta-lactamase found in Klebsiella pneumoniae. PMID:14693513 OXA-47 OXA-48 is a beta-lactamase found in Klebsiella pneumoniae. OXA-48 antibiotic_resistance ARO:3001782 OXA-48 OXA-48 is a beta-lactamase found in Klebsiella pneumoniae. PMID:14693513 OXA-48 OXA-163 is a beta-lactamase found in Klebsiella pneumoniae. OXA-163 antibiotic_resistance ARO:3001783 OXA-163 OXA-163 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21422200 OXA-163 OXA-181 is a beta-lactamase found in Klebsiella pneumoniae. OXA-181 antibiotic_resistance ARO:3001784 OXA-181 OXA-181 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21768505 OXA-181 OXA-73 is a beta-lactamase found in Klebsiella pneumonia. OXA-73 antibiotic_resistance ARO:3001785 OXA-73 OXA-73 is a beta-lactamase found in Klebsiella pneumonia. PMID:22842601 OXA-73 OXA-244 is a beta-lactamase found in Klebsiella pneumoniae. OXA-244 antibiotic_resistance ARO:3001786 OXA-244 OXA-244 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23034714 OXA-244 OXA-245 is a beta-lactamase found in Klebsiella pneumoniae. OXA-245 antibiotic_resistance ARO:3001787 OXA-245 OXA-245 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23034714 OXA-245 OXA-204 is a beta-lactamase found in Klebsiella pneumoniae. OXA-204 antibiotic_resistance ARO:3001788 OXA-204 OXA-204 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23114766 OXA-204 OXA-247 is a beta-lactamase found in Klebsiella pneumoniae. OXA-247 antibiotic_resistance ARO:3001791 OXA-247 OXA-247 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23402333 OXA-247 OXA-62 is a beta-lactamase found in Pandoraea pnomenusa. OXA-62 antibiotic_resistance ARO:3001792 OXA-62 OXA-62 is a beta-lactamase found in Pandoraea pnomenusa. PMID:16569848 OXA-62 OXA-320 is a beta-lactamase found in Proteus mirabilis. OXA-320 antibiotic_resistance ARO:3001793 OXA-320 OXA-320 is a beta-lactamase found in Proteus mirabilis. PMID:24027220 OXA-320 OXA-45 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-45 antibiotic_resistance ARO:3001794 OXA-45 OXA-45 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:12936985 OXA-45 OXA-56 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-56 antibiotic_resistance ARO:3001795 OXA-56 OXA-56 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:15047554 OXA-56 OXA-50 is a beta-lactamase found in Pseudomonas aeruginosa. It confers decreased susceptibility to ampicillin and ticarcillin and, interestingly, to moxalactam and meropenem in P. aeruginosa but not in E. coli. Also confers resistance to piperacillin-tazobactam and cephalotin. OXA-50 antibiotic_resistance ARO:3001796 OXA-50 OXA-50 is a beta-lactamase found in Pseudomonas aeruginosa. It confers decreased susceptibility to ampicillin and ticarcillin and, interestingly, to moxalactam and meropenem in P. aeruginosa but not in E. coli. Also confers resistance to piperacillin-tazobactam and cephalotin. PMID:15155197 OXA-50 OXA-46 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-46 OXA-81 antibiotic_resistance ARO:3001797 OXA-46 OXA-46 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:15855521 OXA-46 OXA-74 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-74 antibiotic_resistance ARO:3001798 OXA-74 OXA-74 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:17634312 OXA-74 OXA-161 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-161 antibiotic_resistance ARO:3001799 OXA-161 OXA-161 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19770278 OXA-161 OXA-226 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-226 antibiotic_resistance ARO:3001800 OXA-226 OXA-226 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19933793 OXA-226 OXA-147 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-147 antibiotic_resistance ARO:3001801 OXA-147 OXA-147 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:20008045 OXA-147 OXA-141 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-141 antibiotic_resistance ARO:3001802 OXA-141 OXA-141 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:20482453 OXA-141 OXA-142 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-142 antibiotic_resistance ARO:3001803 OXA-142 OXA-142 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:20482453 OXA-142 OXA-145 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-145 antibiotic_resistance ARO:3001804 OXA-145 OXA-145 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:21665906 OXA-145 OXA-198 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-198 antibiotic_resistance ARO:3001805 OXA-198 OXA-198 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:21788473 OXA-198 OXA-224 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-224 antibiotic_resistance ARO:3001806 OXA-224 OXA-224 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:22290962 OXA-224 OXA-246 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-246 antibiotic_resistance ARO:3001807 OXA-246 OXA-246 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:24398232 OXA-246 OXA-60 is a beta-lactamase found in Ralstonia pickettii. OXA-60 antibiotic_resistance ARO:3001808 OXA-60 OXA-60 is a beta-lactamase found in Ralstonia pickettii. PMID:15504844 OXA-60 OXA-209 is a beta-lactamase found in Riemerella anatipestifer. OXA-209 antibiotic_resistance ARO:3001809 OXA-209 OXA-209 is a beta-lactamase found in Riemerella anatipestifer. PMID:21820820 OXA-209 OXA-53 is a beta-lactamase found in Salmonella enterica. OXA-53 antibiotic_resistance ARO:3001810 OXA-53 OXA-53 is a beta-lactamase found in Salmonella enterica. PMID:15231768 OXA-53 OXA-129 is a beta-lactamase found in Salmonella enterica. OXA-129 antibiotic_resistance ARO:3001811 OXA-129 OXA-129 is a beta-lactamase found in Salmonella enterica. PMID:18571903 OXA-129 OXA-54 is a beta-lactamase found in Shewanella spp. OXA-54 antibiotic_resistance ARO:3001812 OXA-54 OXA-54 is a beta-lactamase found in Shewanella spp. PMID:14693565 OXA-54 OXA-55 is a beta-lactamase found in Shewanella spp. OXA-55 antibiotic_resistance ARO:3001813 OXA-55 OXA-55 is a beta-lactamase found in Shewanella spp. PMID:15105119 OXA-55 OXA-199 is a beta-lactamase found in Shewanella spp. OXA-199 antibiotic_resistance ARO:3001814 OXA-199 OXA-199 is a beta-lactamase found in Shewanella spp. PMID:23110226 OXA-199 ACC-1 is a beta-lactamase found in Klebsiella pneumoniae. ACC-1 antibiotic_resistance ARO:3001815 ACC-1 ACC-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:10428914 ACC-1 ACC-2 is a beta-lactamase found in Hafnia alvei. ACC-2 antibiotic_resistance ARO:3001816 ACC-2 ACC-2 is a beta-lactamase found in Hafnia alvei. PMID:10817695 ACC-2 ACC-3 is a beta-lactamase found in Hafnia alvei. ACC-3 antibiotic_resistance ARO:3001817 ACC-3 ACC-3 is a beta-lactamase found in Hafnia alvei. PMID:10817695 ACC-3 ACC-4 is a beta-lactamase found in Escherichia coli. ACC-4 antibiotic_resistance ARO:3001818 ACC-4 ACC-4 is a beta-lactamase found in Escherichia coli. PMID:17664321 ACC-4 ACC-5 is a beta-lactamase. From the Lahey list of ACC beta-lactamases. It is detected among Gram-negative bacteria isolates (Gamma- and Alpha-proteobacteria) from urban water sources. ACC-5 antibiotic_resistance ARO:3001819 ACC-5 ACC-5 is a beta-lactamase. From the Lahey list of ACC beta-lactamases. It is detected among Gram-negative bacteria isolates (Gamma- and Alpha-proteobacteria) from urban water sources. PMID:24267783 ACC-5 ACT-1 is a beta-lactamase found in Klebsiella pneumoniae. ACT-1 antibiotic_resistance ARO:3001821 ACT-1 ACT-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:9055993 ACT-1 ACT-2 is a beta-lactamase found in Klebsiella pneumoniae. ACT-2 antibiotic_resistance ARO:3001822 ACT-2 ACT-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23093031 ACT-2 ACT-3 is a beta-lactamase found in Klebsiella pneumoniae. ACT-3 antibiotic_resistance ARO:3001823 ACT-3 ACT-3 is a beta-lactamase found in Klebsiella pneumoniae. PMID:18789849 ACT-3 ACT-5 is a beta-lactamase found in Escherichia coli. ACT-5 antibiotic_resistance ARO:3001824 ACT-5 ACT-5 is a beta-lactamase found in Escherichia coli. PMID:23643553 ACT-5 ACT-6 is a beta-lactamase found in Klebsiella pneumoniae. ACT-6 antibiotic_resistance ARO:3001825 ACT-6 ACT-6 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21304534 ACT-6 ACT-9 is a beta-lactamase found in Pantoea agglomerans. ACT-9 antibiotic_resistance ARO:3001826 ACT-9 ACT-9 is a beta-lactamase found in Pantoea agglomerans. PMID:21690276 ACT-9 ACT-16 is a beta-lactamase found in Enterobacteriaceae. ACT-16 antibiotic_resistance ARO:3001827 ACT-16 ACT-16 is a beta-lactamase found in Enterobacteriaceae. PMID:24336426 ACT-16 ACT-23 is a beta-lactamase found in Escherichia coli. ACT-23 antibiotic_resistance ARO:3001828 ACT-23 ACT-23 is a beta-lactamase found in Escherichia coli. PMID:24629772 ACT-23 ACT-4 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-4 antibiotic_resistance ARO:3001829 ACT-4 ACT-4 ACT-7 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-7 antibiotic_resistance ARO:3001830 ACT-7 ACT-7 ACT-8 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-8 antibiotic_resistance ARO:3001831 ACT-8 ACT-8 ACT-10 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-10 antibiotic_resistance ARO:3001832 ACT-10 ACT-10 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. PMID:25312010 ACT-10 ACT-11 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. antibiotic_resistance ARO:3001833 ACT-11 ACT-12 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-12 antibiotic_resistance ARO:3001834 ACT-12 ACT-12 ACT-13 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-13 antibiotic_resistance ARO:3001835 ACT-13 ACT-13 ACT-14 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-14 antibiotic_resistance ARO:3001836 ACT-14 ACT-14 ACT-15 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-15 antibiotic_resistance ARO:3001837 ACT-15 ACT-15 ACT-17 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-17 antibiotic_resistance ARO:3001838 ACT-17 ACT-17 ACT-18 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-18 antibiotic_resistance ARO:3001839 ACT-18 ACT-18 ACT-19 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-19 antibiotic_resistance ARO:3001840 ACT-19 ACT-19 ACT-20 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-20 antibiotic_resistance ARO:3001841 ACT-20 ACT-20 ACT-21 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-21 antibiotic_resistance ARO:3001842 ACT-21 ACT-21 ACT-22 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-22 antibiotic_resistance ARO:3001843 ACT-22 ACT-22 ACT-24 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-24 antibiotic_resistance ARO:3001844 ACT-24 ACT-24 ACT-25 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-25 antibiotic_resistance ARO:3001845 ACT-25 ACT-25 ACT-27 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-27 antibiotic_resistance ARO:3001847 ACT-27 ACT-27 ACT-28 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-28 antibiotic_resistance ARO:3001848 ACT-28 ACT-28 ACT-29 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-29 antibiotic_resistance ARO:3001849 ACT-29 ACT-29 ACT-30 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-30 antibiotic_resistance ARO:3001850 ACT-30 ACT-30 ACT-31 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-31 antibiotic_resistance ARO:3001851 ACT-31 ACT-31 ACT-32 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-32 antibiotic_resistance ARO:3001852 ACT-32 ACT-32 ACT-33 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-33 antibiotic_resistance ARO:3001853 ACT-33 ACT-33 ACT-34 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-34 antibiotic_resistance ARO:3001854 ACT-34 ACT-34 ACT-35 is a beta-lactamase. From the Lahey list of ACT beta-lactamases. ACT-35 antibiotic_resistance ARO:3001855 ACT-35 ACT-35 CFE-1 is a beta-lactamase found in Escherichia coli. CFE-1 antibiotic_resistance ARO:3001856 CFE-1 CFE-1 is a beta-lactamase found in Escherichia coli. PMID:15047515 CFE-1 LAT-1 is a beta-lactamase found in Klebsiella pneumoniae. LAT-1 LAT-4 antibiotic_resistance ARO:3001857 LAT-1 LAT-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:7811049 LAT-1 IMI-1 is a beta-lactamase found in Enterobacter cloacae. IMI-1 antibiotic_resistance ARO:3001858 IMI-1 IMI-1 is a beta-lactamase found in Enterobacter cloacae. PMID:8878585 IMI-1 IMI-2 is a beta-lactamase found in Enterobacteriaceae. IMI-2 antibiotic_resistance ARO:3001859 IMI-2 IMI-2 is a beta-lactamase found in Enterobacteriaceae. PMID:15752444 PMID:21192875 IMI-2 IMI-3 is a beta-lactamase found in Enterobacteriaceae. IMI-3 antibiotic_resistance ARO:3001860 IMI-3 IMI-3 is a beta-lactamase found in Enterobacteriaceae. PMID:21192875 IMI-3 IMI-4 is a beta-lactamase. From the Lahey list of IMI beta-lactamases. IMI-4 antibiotic_resistance ARO:3001861 IMI-4 IMI-4 IMI-5 is a beta-lactamase. From the Lahey list of IMI beta-lactamases. IMI-5 antibiotic_resistance ARO:3001862 IMI-5 IMI-5 IMI-6 is a beta-lactamase. From the Lahey list of IMI beta-lactamases. IMI-6 antibiotic_resistance ARO:3001863 IMI-6 IMI-6 CTX-M-1 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-1 MEN-1 antibiotic_resistance ARO:3001864 CTX-M-1 CTX-M-1 is a beta-lactamase found in the Enterobacteriaceae family. PMID:8834913 CTX-M-1 CTX-M-2 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-2 antibiotic_resistance ARO:3001865 CTX-M-2 CTX-M-2 is a beta-lactamase found in the Enterobacteriaceae family. PMID:8834913 CTX-M-2 CTX-M-3 is a beta-lactamase found in Citrobacter freundii. CTX-M-133 CTX-M-3 antibiotic_resistance ARO:3001866 CTX-M-3 CTX-M-3 is a beta-lactamase found in Citrobacter freundii. PMID:33416461 PMID:9559791 CTX-M-3 CTX-M-4 is a beta-lactamase found in Salmonella typhimurium. CTX-M-4 antibiotic_resistance ARO:3001867 CTX-M-4 CTX-M-4 is a beta-lactamase found in Salmonella typhimurium. PMID:9593162 CTX-M-4 CTX-M-5 is a beta-lactamase found in Salmonella typhimurium. CTX-M-5 antibiotic_resistance ARO:3001868 CTX-M-5 CTX-M-5 is a beta-lactamase found in Salmonella typhimurium. PMID:9687393 CTX-M-5 CTX-M-6 is a beta-lactamase found in Salmonella typhimurium. CTX-M-6 antibiotic_resistance ARO:3001869 CTX-M-6 CTX-M-6 is a beta-lactamase found in Salmonella typhimurium. PMID:9742701 CTX-M-6 CTX-M-7 is a beta-lactamase found in Salmonella typhimurium. CTX-M-7 antibiotic_resistance ARO:3001870 CTX-M-7 CTX-M-7 is a beta-lactamase found in Salmonella typhimurium. PMID:9742701 CTX-M-7 CTX-M-8 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-8 antibiotic_resistance ARO:3001871 CTX-M-8 CTX-M-8 is a beta-lactamase found in the Enterobacteriaceae family. PMID:10858358 CTX-M-8 CTX-M-9 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-9 antibiotic_resistance ARO:3001872 CTX-M-9 CTX-M-9 is a beta-lactamase found in the Enterobacteriaceae family. PMID:11850241 CTX-M-9 CTX-M-10 is a beta-lactamase found in Escherichia coli. CTX-M-10 antibiotic_resistance ARO:3001873 CTX-M-10 CTX-M-10 is a beta-lactamase found in Escherichia coli. PMID:11158766 CTX-M-10 CTX-M-11 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-11 antibiotic_resistance ARO:3001874 CTX-M-11 CTX-M-11 CTX-M-12 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-12 antibiotic_resistance ARO:3001875 CTX-M-12 CTX-M-12 is a beta-lactamase found in Klebsiella pneumoniae. PMID:11408239 CTX-M-12 CTX-M-13 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-13 antibiotic_resistance ARO:3001876 CTX-M-13 CTX-M-13 is a beta-lactamase found in the Enterobacteriaceae family. PMID:11850241 CTX-M-13 CTX-M-14 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-14 CTX-M-18 antibiotic_resistance ARO:3001877 CTX-M-14 CTX-M-14 is a beta-lactamase found in the Enterobacteriaceae family. PMID:11850241 CTX-M-14 CTX-M-15 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-15 UOE-1 antibiotic_resistance ARO:3001878 CTX-M-15 CTX-M-15 is a beta-lactamase found in the Enterobacteriaceae family. PMID:11470367 PMID:12461028 PMID:33416461 CTX-M-15 CTX-M-16 is a beta-lactamase found in Escherichia coli. CTX-M-16 antibiotic_resistance ARO:3001879 CTX-M-16 CTX-M-16 is a beta-lactamase found in Escherichia coli. PMID:11451684 CTX-M-16 CTX-M-17 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-17 antibiotic_resistance ARO:3001880 CTX-M-17 CTX-M-17 is a beta-lactamase found in Klebsiella pneumoniae. PMID:11959547 CTX-M-17 CTX-M-19 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-19 antibiotic_resistance ARO:3001881 CTX-M-19 CTX-M-19 is a beta-lactamase found in Klebsiella pneumoniae. PMID:11709308 CTX-M-19 CTX-M-20 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-20 antibiotic_resistance ARO:3001882 CTX-M-20 CTX-M-20 is a beta-lactamase found in the Enterobacteriaceae family. PMID:12007800 CTX-M-20 CTX-M-21 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-21 antibiotic_resistance ARO:3001883 CTX-M-21 CTX-M-21 is a beta-lactamase found in the Enterobacteriaceae family. PMID:12007800 CTX-M-21 CTX-M-22 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-22 antibiotic_resistance ARO:3001884 CTX-M-22 CTX-M-22 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16533535 CTX-M-22 CTX-M-23 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-23 antibiotic_resistance ARO:3001885 CTX-M-23 CTX-M-23 is a beta-lactamase found in the Enterobacteriaceae family. PMID:15201232 CTX-M-23 CTX-M-24 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-24 antibiotic_resistance ARO:3001886 CTX-M-24 CTX-M-24 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16291869 CTX-M-24 CTX-M-25 is a beta-lactamase found in Escherichia coli. CTX-M-25 antibiotic_resistance ARO:3001887 CTX-M-25 CTX-M-25 is a beta-lactamase found in Escherichia coli. PMID:15561863 CTX-M-25 CTX-M-26 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-26 antibiotic_resistance ARO:3001888 CTX-M-26 CTX-M-26 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15561863 CTX-M-26 CTX-M-27 is a beta-lactamase found in Escherichia coli. CTX-M-27 antibiotic_resistance ARO:3001889 CTX-M-27 CTX-M-27 is a beta-lactamase found in Escherichia coli. PMID:12775683 PMID:33416461 CTX-M-27 CTX-M-28 is a beta-lactamase found in Salmonella enterica. CTX-M-28 antibiotic_resistance ARO:3001890 CTX-M-28 CTX-M-28 is a beta-lactamase found in Salmonella enterica. PMID:15941775 CTX-M-28 CTX-M-29 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-29 antibiotic_resistance ARO:3001891 CTX-M-29 CTX-M-29 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16533535 CTX-M-29 CTX-M-30 is a beta-lactamase found in Citrobacter freundii. CTX-M-30 antibiotic_resistance ARO:3001892 CTX-M-30 CTX-M-30 is a beta-lactamase found in Citrobacter freundii. PMID:15504875 CTX-M-30 CTX-M-31 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-31 antibiotic_resistance ARO:3001893 CTX-M-31 CTX-M-31 is a beta-lactamase found in the Enterobacteriaceae family. PMID:12936986 CTX-M-31 CTX-M-32 is a beta-lactamase found in Escherichia coli. CTX-M-32 antibiotic_resistance ARO:3001894 CTX-M-32 CTX-M-32 is a beta-lactamase found in Escherichia coli. PMID:15155242 CTX-M-32 CTX-M-33 is a beta-lactamase found in Salmonella enterica. CTX-M-33 antibiotic_resistance ARO:3001895 CTX-M-33 CTX-M-33 is a beta-lactamase found in Salmonella enterica. PMID:17234386 CTX-M-33 CTX-M-34 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-34 antibiotic_resistance ARO:3001896 CTX-M-34 CTX-M-34 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16244084 CTX-M-34 CTX-M-35 is a beta-lactamase found in Citrobacter koseri. CTX-M-35 antibiotic_resistance ARO:3001897 CTX-M-35 CTX-M-35 is a beta-lactamase found in Citrobacter koseri. PMID:20138478 CTX-M-35 CTX-M-36 is a beta-lactamase found in Escherichia coli. CTX-M-36 antibiotic_resistance ARO:3001898 CTX-M-36 CTX-M-36 is a beta-lactamase found in Escherichia coli. PMID:21940649 CTX-M-36 CTX-M-37 is a beta-lactamase found in Salmonella enterica. CTX-M-37 antibiotic_resistance ARO:3001899 CTX-M-37 CTX-M-37 is a beta-lactamase found in Salmonella enterica. PMID:16949257 CTX-M-37 CTX-M-38 is a beta-lactamase found in Escherichia coli. CTX-M-38 antibiotic_resistance ARO:3001900 CTX-M-38 CTX-M-38 is a beta-lactamase found in Escherichia coli. PMID:19927355 CTX-M-38 CTX-M-39 is a beta-lactamase found in Escherichia coli. CTX-M-39 antibiotic_resistance ARO:3001901 CTX-M-39 CTX-M-39 is a beta-lactamase found in Escherichia coli. PMID:16251320 CTX-M-39 CTX-M-40 is a beta-lactamase found in Escherichia coli. CTX-M-40 antibiotic_resistance ARO:3001902 CTX-M-40 CTX-M-40 is a beta-lactamase found in Escherichia coli. PMID:16697557 CTX-M-40 CTX-M-41 is a beta-lactamase found in Proteus mirabilis. CTX-M-41 antibiotic_resistance ARO:3001903 CTX-M-41 CTX-M-41 is a beta-lactamase found in Proteus mirabilis. PMID:18487232 CTX-M-41 CTX-M-42 is a beta-lactamase found in Escherichia coli. CTX-M-42 antibiotic_resistance ARO:3001904 CTX-M-42 CTX-M-42 is a beta-lactamase found in Escherichia coli. PMID:18212109 CTX-M-42 CTX-M-43 is a beta-lactamase found in Pseudomonas aeruginosa and Acinetobacter spp. CTX-M-43 antibiotic_resistance ARO:3001905 CTX-M-43 CTX-M-43 is a beta-lactamase found in Pseudomonas aeruginosa and Acinetobacter spp. PMID:16510850 CTX-M-43 CTX-M-44 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-44 Toho-1 antibiotic_resistance ARO:3001906 CTX-M-44 CTX-M-44 is a beta-lactamase found in the Enterobacteriaceae family. PMID:21078949 CTX-M-44 CTX-M-45 is a beta-lactamase found in Escherichia coli. CTX-M-45 Toho-2 antibiotic_resistance ARO:3001907 CTX-M-45 CTX-M-45 is a beta-lactamase found in Escherichia coli. PMID:9593147 CTX-M-45 CTX-M-46 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-46 antibiotic_resistance ARO:3001908 CTX-M-46 CTX-M-46 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16082008 CTX-M-46 CTX-M-47 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-47 antibiotic_resistance ARO:3001909 CTX-M-47 CTX-M-47 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16082008 CTX-M-47 CTX-M-48 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-48 antibiotic_resistance ARO:3001910 CTX-M-48 CTX-M-48 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16082008 CTX-M-48 CTX-M-49 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-49 antibiotic_resistance ARO:3001911 CTX-M-49 CTX-M-49 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16082008 CTX-M-49 CTX-M-50 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-50 antibiotic_resistance ARO:3001912 CTX-M-50 CTX-M-50 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16082008 CTX-M-50 CTX-M-51 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-51 antibiotic_resistance ARO:3001913 CTX-M-51 CTX-M-51 CTX-M-52 is a beta-lactamase found in Escherichia coli. CTX-M-52 antibiotic_resistance ARO:3001914 CTX-M-52 CTX-M-52 is a beta-lactamase found in Escherichia coli. PMID:15736704 CTX-M-52 CTX-M-53 is a beta-lactamase found in Salmonella enterica. CTX-M-53 antibiotic_resistance ARO:3001915 CTX-M-53 CTX-M-53 is a beta-lactamase found in Salmonella enterica. PMID:19273683 CTX-M-53 CTX-M-54 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-54 antibiotic_resistance ARO:3001916 CTX-M-54 CTX-M-54 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16785225 CTX-M-54 CTX-M-55 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-55 CTX-M-57 antibiotic_resistance ARO:3001917 CTX-M-55 CTX-M-55 is a beta-lactamase found in the Enterobacteriaceae family. PMID:17449211 CTX-M-55 CTX-M-56 is a beta-lactamase found in Escherichia coli. CTX-M-56 antibiotic_resistance ARO:3001918 CTX-M-56 CTX-M-56 is a beta-lactamase found in Escherichia coli. PMID:17548490 CTX-M-56 CTX-M-58 is a beta-lactamase found in Escherichia coli. CTX-M-58 antibiotic_resistance ARO:3001919 CTX-M-58 CTX-M-58 is a beta-lactamase found in Escherichia coli. PMID:21788458 CTX-M-58 CTX-M-59 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-59 antibiotic_resistance ARO:3001920 CTX-M-59 CTX-M-59 is a beta-lactamase found in Klebsiella pneumoniae. PMID:18347108 CTX-M-59 CTX-M-60 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-60 antibiotic_resistance ARO:3001921 CTX-M-60 CTX-M-60 CTX-M-61 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-61 antibiotic_resistance ARO:3001922 CTX-M-61 CTX-M-61 is a beta-lactamase found in the Enterobacteriaceae family. PMID:17804424 CTX-M-61 CTX-M-62 is a beta-lactamase found in Escherichia coli. CTX-M-62 antibiotic_resistance ARO:3001923 CTX-M-62 CTX-M-62 is a beta-lactamase found in Escherichia coli. PMID:18725449 CTX-M-62 CTX-M-63 is a beta-lactamase found in Salmonella enterica. CTX-M-63 antibiotic_resistance ARO:3001924 CTX-M-63 CTX-M-63 is a beta-lactamase found in Salmonella enterica. PMID:21034262 CTX-M-63 CTX-M-64 is a beta-lactamase found in Shigella sonnei. CTX-M-64 antibiotic_resistance ARO:3001925 CTX-M-64 CTX-M-64 is a beta-lactamase found in Shigella sonnei. PMID:18955524 CTX-M-64 CTX-M-65 is a beta-lactamase found in Escherichia coli. CTX-M-65 antibiotic_resistance ARO:3001926 CTX-M-65 CTX-M-65 is a beta-lactamase found in Escherichia coli. PMID:18195064 CTX-M-65 CTX-M-66 is a beta-lactamase found in Proteus mirabilis. CTX-M-66 antibiotic_resistance ARO:3001927 CTX-M-66 CTX-M-66 is a beta-lactamase found in Proteus mirabilis. PMID:17913434 CTX-M-66 CTX-M-67 is a beta-lactamase found in Escherichia coli. CTX-M-67 antibiotic_resistance ARO:3001928 CTX-M-67 CTX-M-67 is a beta-lactamase found in Escherichia coli. PMID:18775649 CTX-M-67 CTX-M-68 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-68 antibiotic_resistance ARO:3001929 CTX-M-68 CTX-M-68 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19748232 CTX-M-68 CTX-M-69 is a beta-lactamase found in Escherichia coli. CTX-M-69 antibiotic_resistance ARO:3001930 CTX-M-69 CTX-M-69 is a beta-lactamase found in Escherichia coli. PMID:21940649 CTX-M-69 CTX-M-70 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. antibiotic_resistance ARO:3001931 CTX-M-70 CTX-M-71 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-71 antibiotic_resistance ARO:3001932 CTX-M-71 CTX-M-71 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19620330 CTX-M-71 CTX-M-72 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-72 antibiotic_resistance ARO:3001933 CTX-M-72 CTX-M-72 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19590148 CTX-M-72 CTX-M-73 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-73 antibiotic_resistance ARO:3001934 CTX-M-73 CTX-M-73 CTX-M-74 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-74 antibiotic_resistance ARO:3001935 CTX-M-74 CTX-M-74 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19748435 CTX-M-74 CTX-M-75 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-75 antibiotic_resistance ARO:3001936 CTX-M-75 CTX-M-75 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19748435 CTX-M-75 CTX-M-76 is a beta-lactamase found in Kluyvera spp. CTX-M-76 antibiotic_resistance ARO:3001937 CTX-M-76 CTX-M-76 is a beta-lactamase found in Kluyvera spp. PMID:22697133 CTX-M-76 CTX-M-77 is a beta-lactamase found in Kluyvera spp. CTX-M-77 antibiotic_resistance ARO:3001938 CTX-M-77 CTX-M-77 is a beta-lactamase found in Kluyvera spp. PMID:22697133 CTX-M-77 CTX-M-78 is a beta-lactamase found in Kluyvera georgiana. CTX-M-78 antibiotic_resistance ARO:3001939 CTX-M-78 CTX-M-78 is a beta-lactamase found in Kluyvera georgiana. PMID:20421403 CTX-M-78 CTX-M-79 is a beta-lactamase found in Escherichia coli. CTX-M-79 antibiotic_resistance ARO:3001940 CTX-M-79 CTX-M-79 is a beta-lactamase found in Escherichia coli. PMID:18772941 CTX-M-79 CTX-M-80 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-80 antibiotic_resistance ARO:3001941 CTX-M-80 CTX-M-80 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19294528 CTX-M-80 CTX-M-81 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-81 antibiotic_resistance ARO:3001942 CTX-M-81 CTX-M-81 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19294528 CTX-M-81 CTX-M-82 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-82 antibiotic_resistance ARO:3001943 CTX-M-82 CTX-M-82 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19297379 CTX-M-82 CTX-M-83 is a beta-lactamase found in Salmonella enterica. CTX-M-83 antibiotic_resistance ARO:3001944 CTX-M-83 CTX-M-83 is a beta-lactamase found in Salmonella enterica. PMID:18984647 CTX-M-83 CTX-M-84 is a beta-lactamase found in Salmonella enterica. CTX-M-84 antibiotic_resistance ARO:3001945 CTX-M-84 CTX-M-84 is a beta-lactamase found in Salmonella enterica. PMID:18984647 CTX-M-84 CTX-M-86 is a beta-lactamase found in Salmonella enterica. CTX-M-86 antibiotic_resistance ARO:3001946 CTX-M-86 CTX-M-86 is a beta-lactamase found in Salmonella enterica. PMID:18984647 CTX-M-86 CTX-M-87 is a beta-lactamase found in Escherichia coli. CTX-M-87 antibiotic_resistance ARO:3001947 CTX-M-87 CTX-M-87 is a beta-lactamase found in Escherichia coli. PMID:19429759 CTX-M-87 CTX-M-88 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-88 antibiotic_resistance ARO:3001948 CTX-M-88 CTX-M-88 CTX-M-89 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-89 antibiotic_resistance ARO:3001949 CTX-M-89 CTX-M-89 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19587301 CTX-M-89 CTX-M-90 is a beta-lactamase found in Proteus mirabilis. CTX-M-90 antibiotic_resistance ARO:3001950 CTX-M-90 CTX-M-90 is a beta-lactamase found in Proteus mirabilis. PMID:21282448 CTX-M-90 CTX-M-91 is a beta-lactamase found in Escherichia coli. CTX-M-91 antibiotic_resistance ARO:3001951 CTX-M-91 CTX-M-91 is a beta-lactamase found in Escherichia coli. PMID:22450980 CTX-M-91 CTX-M-92 is a beta-lactamase found in Escherichia coli. CTX-M-92 antibiotic_resistance ARO:3001952 CTX-M-92 CTX-M-92 is a beta-lactamase found in Escherichia coli. PMID:24589574 CTX-M-92 CTX-M-93 is a beta-lactamase found in Escherichia coli. CTX-M-93 antibiotic_resistance ARO:3001953 CTX-M-93 CTX-M-93 is a beta-lactamase found in Escherichia coli. PMID:21343457 CTX-M-93 CTX-M-94 is a beta-lactamase found in Escherichia coli. CTX-M-94 antibiotic_resistance ARO:3001954 CTX-M-94 CTX-M-94 is a beta-lactamase found in Escherichia coli. PMID:23050014 CTX-M-94 CTX-M-95 is a beta-lactamase found in Kluyvera spp. CTX-M-95 antibiotic_resistance ARO:3001955 CTX-M-95 CTX-M-95 is a beta-lactamase found in Kluyvera spp. PMID:22697133 CTX-M-95 CTX-M-96 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-96 antibiotic_resistance ARO:3001956 CTX-M-96 CTX-M-96 CTX-M-98 is a beta-lactamase found in Escherichia coli. CTX-M-98 antibiotic_resistance ARO:3001957 CTX-M-98 CTX-M-98 is a beta-lactamase found in Escherichia coli. PMID:22325120 CTX-M-98 CTX-M-99 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-99 antibiotic_resistance ARO:3001958 CTX-M-99 CTX-M-99 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23034125 CTX-M-99 CTX-M-100 is a beta-lactamase found in Escherichia coli. CTX-M-100 antibiotic_resistance ARO:3001959 CTX-M-100 CTX-M-100 is a beta-lactamase found in Escherichia coli. PMID:23050014 CTX-M-100 CTX-M-101 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-101 antibiotic_resistance ARO:3001960 CTX-M-101 CTX-M-101 CTX-M-102 is a beta-lactamase found in Escherichia coli. CTX-M-102 antibiotic_resistance ARO:3001961 CTX-M-102 CTX-M-102 is a beta-lactamase found in Escherichia coli. PMID:22325120 CTX-M-102 CTX-M-103 is a beta-lactamase found in Escherichia coli. CTX-M-103 antibiotic_resistance ARO:3001962 CTX-M-103 CTX-M-103 is a beta-lactamase found in Escherichia coli. PMID:23926164 CTX-M-103 CTX-M-104 is a beta-lactamase found in Escherichia coli. CTX-M-104 antibiotic_resistance ARO:3001963 CTX-M-104 CTX-M-104 is a beta-lactamase found in Escherichia coli. PMID:22325120 CTX-M-104 CTX-M-105 is a beta-lactamase found in Escherichia coli. CTX-M-105 antibiotic_resistance ARO:3001965 CTX-M-105 CTX-M-105 is a beta-lactamase found in Escherichia coli. PMID:22407683 CTX-M-105 CTX-M-106 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-106 antibiotic_resistance ARO:3001966 CTX-M-106 CTX-M-106 CTX-M-107 is a beta-lactamase found in Shigella spp. CTX-M-107 antibiotic_resistance ARO:3001967 CTX-M-107 CTX-M-107 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-107 CTX-M-108 is a beta-lactamase found in Shigella spp. CTX-M-108 antibiotic_resistance ARO:3001968 CTX-M-108 CTX-M-108 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-108 CTX-M-109 is a beta-lactamase found in Shigella spp. CTX-M-109 antibiotic_resistance ARO:3001969 CTX-M-109 CTX-M-109 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-109 CTX-M-110 is a beta-lactamase found in Shigella spp. CTX-M-110 antibiotic_resistance ARO:3001970 CTX-M-110 CTX-M-110 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-110 CTX-M-111 is a beta-lactamase found in Shigella spp. CTX-M-111 antibiotic_resistance ARO:3001971 CTX-M-111 CTX-M-111 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-111 CTX-M-112 is a beta-lactamase found in Shigella spp. CTX-M-112 antibiotic_resistance ARO:3001972 CTX-M-112 CTX-M-112 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-112 CTX-M-113 is a beta-lactamase found in Shigella spp. CTX-M-113 antibiotic_resistance ARO:3001973 CTX-M-113 CTX-M-113 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-113 CTX-M-114 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-114 antibiotic_resistance ARO:3001974 CTX-M-114 CTX-M-114 CTX-M-115 is a beta-lactamase found in Acinetobacter baumannii. CTX-M-115 antibiotic_resistance ARO:3001975 CTX-M-115 CTX-M-115 is a beta-lactamase found in Acinetobacter baumannii. PMID:23982021 CTX-M-115 CTX-M-116 is a beta-lactamase found in Proteus mirabilis. CTX-M-116 antibiotic_resistance ARO:3001976 CTX-M-116 CTX-M-116 is a beta-lactamase found in Proteus mirabilis. PMID:23318795 CTX-M-116 CTX-M-117 is a beta-lactamase found in Escherichia coli. CTX-M-117 antibiotic_resistance ARO:3001977 CTX-M-117 CTX-M-117 is a beta-lactamase found in Escherichia coli. PMID:23127481 CTX-M-117 CTX-M-119 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. antibiotic_resistance ARO:3001978 CTX-M-119 CTX-M-120 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. antibiotic_resistance ARO:3001979 CTX-M-120 CTX-M-121 is a beta-lactamase found in Escherichia coli. CTX-M-121 antibiotic_resistance ARO:3001980 CTX-M-121 CTX-M-121 is a beta-lactamase found in Escherichia coli. PMID:23892737 CTX-M-121 CTX-M-122 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-122 antibiotic_resistance ARO:3001981 CTX-M-122 CTX-M-122 CTX-M-123 is a beta-lactamase found in Escherichia coli. CTX-M-123 antibiotic_resistance ARO:3001982 CTX-M-123 CTX-M-123 is a beta-lactamase found in Escherichia coli. PMID:23752509 CTX-M-123 CTX-M-124 is a beta-lactamase found in Escherichia coli. CTX-M-124 antibiotic_resistance ARO:3001983 CTX-M-124 CTX-M-124 is a beta-lactamase found in Escherichia coli. PMID:22314536 CTX-M-124 CTX-M-125 is a beta-lactamase found in Escherichia coli. CTX-M-125 antibiotic_resistance ARO:3001984 CTX-M-125 CTX-M-125 is a beta-lactamase found in Escherichia coli. PMID:24040123 CTX-M-125 CTX-M-126 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-126 antibiotic_resistance ARO:3001985 CTX-M-126 CTX-M-126 CTX-M-127 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-127 antibiotic_resistance ARO:3001986 CTX-M-127 CTX-M-127 CTX-M-128 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. antibiotic_resistance ARO:3001987 CTX-M-128 CTX-M-129 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-129 antibiotic_resistance ARO:3001988 CTX-M-129 CTX-M-129 CTX-M-130 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-130 antibiotic_resistance ARO:3001989 CTX-M-130 CTX-M-130 CTX-M-131 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-131 antibiotic_resistance ARO:3001990 CTX-M-131 CTX-M-131 CTX-M-132 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-132 antibiotic_resistance ARO:3001991 CTX-M-132 CTX-M-132 CTX-M-134 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-134 antibiotic_resistance ARO:3001992 CTX-M-134 CTX-M-134 CTX-M-135 is a beta-lactamase found in the Enterobacteriaceae family. antibiotic_resistance ARO:3001993 CTX-M-135 CTX-M-135 is a beta-lactamase found in the Enterobacteriaceae family. PMID:24637692 CTX-M-137 is a beta-lactamase found in Escherichia coli. CTX-M-137 antibiotic_resistance ARO:3001994 CTX-M-137 CTX-M-137 CTX-M-136 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-136 antibiotic_resistance ARO:3001995 CTX-M-136 CTX-M-136 CTX-M-138 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-138 antibiotic_resistance ARO:3001996 CTX-M-138 CTX-M-138 CTX-M-139 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-139 antibiotic_resistance ARO:3001997 CTX-M-139 CTX-M-139 CTX-M-140 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-140 antibiotic_resistance ARO:3001998 CTX-M-140 CTX-M-140 CTX-M-141 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-141 antibiotic_resistance ARO:3001999 CTX-M-141 CTX-M-141 CTX-M-142 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-142 antibiotic_resistance ARO:3002000 CTX-M-142 CTX-M-142 CTX-M-143 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-143 antibiotic_resistance ARO:3002001 CTX-M-143 CTX-M-143 CTX-M-144 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-144 antibiotic_resistance ARO:3002002 CTX-M-144 CTX-M-144 CTX-M-145 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. antibiotic_resistance ARO:3002003 CTX-M-145 CTX-M-146 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-146 antibiotic_resistance ARO:3002004 CTX-M-146 CTX-M-146 CTX-M-147 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-147 antibiotic_resistance ARO:3002005 CTX-M-147 CTX-M-147 CTX-M-148 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-148 antibiotic_resistance ARO:3002006 CTX-M-148 CTX-M-148 CTX-M-150 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-150 antibiotic_resistance ARO:3002007 CTX-M-150 CTX-M-150 CTX-M-151 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-151 antibiotic_resistance ARO:3002008 CTX-M-151 CTX-M-151 CTX-M-152 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-152 antibiotic_resistance ARO:3002009 CTX-M-152 CTX-M-152 CTX-M-153 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-153 antibiotic_resistance ARO:3002010 CTX-M-153 CTX-M-153 CTX-M-154 is a beta-lactamase. From the Lahey list of CTX-M beta-lactamases. CTX-M-154 antibiotic_resistance ARO:3002011 CTX-M-154 CTX-M-154 CMY-1 is a beta-lactamase found in the Enterobacteriaceae family. CMY-1 antibiotic_resistance ARO:3002012 CMY-1 CMY-1 is a beta-lactamase found in the Enterobacteriaceae family. PMID:8843306 CMY-1 CMY-2 is a beta-lactamase found in Klebsiella pneumoniae. BIL-1, LAT-2 CMY-2 antibiotic_resistance ARO:3002013 CMY-2 CMY-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:33416461 PMID:8787910 CMY-2 CMY-3 is a beta-lactamase found in Proteus mirabilis. antibiotic_resistance ARO:3002014 CMY-3 CMY-3 is a beta-lactamase found in Proteus mirabilis. PMID:9593136 CMY-4 is a beta-lactamase found in Proteus mirabilis. CMY-4 antibiotic_resistance ARO:3002015 CMY-4 CMY-4 is a beta-lactamase found in Proteus mirabilis. PMID:9868767 CMY-4 CMY-5 is a beta-lactamase found in Klebsiella oxytoca. CMY-5 antibiotic_resistance ARO:3002016 CMY-5 CMY-5 is a beta-lactamase found in Klebsiella oxytoca. PMID:10348751 CMY-5 CMY-6 is a beta-lactamase found in Escherichia coli. CMY-6 LAT-3 antibiotic_resistance ARO:3002017 CMY-6 CMY-6 is a beta-lactamase found in Escherichia coli. PMID:9818739 CMY-6 CMY-7 is a beta-lactamase found in Salmonella typhimurium. CMY-7 antibiotic_resistance ARO:3002018 CMY-7 CMY-7 is a beta-lactamase found in Salmonella typhimurium. PMID:12039894 CMY-7 CMY-8 is a beta-lactamase found in Klebsiella pneumoniae. CMY-8 antibiotic_resistance ARO:3002019 CMY-8 CMY-8 is a beta-lactamase found in Klebsiella pneumoniae. PMID:10817689 CMY-8 CMY-9 is a beta-lactamase found in Escherichia coli. CMY-9 antibiotic_resistance ARO:3002020 CMY-9 CMY-9 is a beta-lactamase found in Escherichia coli. PMID:12121914 CMY-9 CMY-10 is a beta-lactamase found in Klebsiella aerogenes. CMY-10 antibiotic_resistance ARO:3002021 CMY-10 CMY-10 is a beta-lactamase found in Klebsiella aerogenes. PMID:12969288 CMY-10 CMY-11 is a beta-lactamase found in Escherichia coli. CMY-11 antibiotic_resistance ARO:3002022 CMY-11 CMY-11 is a beta-lactamase found in Escherichia coli. PMID:11815567 CMY-11 CMY-12 is a beta-lactamase found in the Enterobacteriaceae family. CMY-12 antibiotic_resistance ARO:3002023 CMY-12 CMY-12 is a beta-lactamase found in the Enterobacteriaceae family. PMID:12407124 CMY-12 CMY-13 is a beta-lactamase found in Escherichia coli. CMY-13 antibiotic_resistance ARO:3002024 CMY-13 CMY-13 is a beta-lactamase found in Escherichia coli. PMID:15273143 CMY-13 CMY-14 is a beta-lactamase found in Proteus mirabilis. CMY-14 antibiotic_resistance ARO:3002025 CMY-14 CMY-14 is a beta-lactamase found in Proteus mirabilis. PMID:15504832 CMY-14 CMY-15 is a beta-lactamase found in Proteus mirabilis. CMY-15 antibiotic_resistance ARO:3002026 CMY-15 CMY-15 is a beta-lactamase found in Proteus mirabilis. PMID:15504832 CMY-15 CMY-16 is a beta-lactamase found in Proteus mirabilis. CMY-16 antibiotic_resistance ARO:3002027 CMY-16 CMY-16 is a beta-lactamase found in Proteus mirabilis. PMID:16436718 CMY-16 CMY-17 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-17 antibiotic_resistance ARO:3002028 CMY-17 CMY-17 CMY-18 is a beta-lactamase found in the Enterobacteriaceae family. CMY-18 antibiotic_resistance ARO:3002029 CMY-18 CMY-18 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16584308 CMY-18 CMY-19 is a beta-lactamase found in Klebsiella pneumoniae. CMY-19 antibiotic_resistance ARO:3002030 CMY-19 CMY-19 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16436707 CMY-19 CMY-20 is a beta-lactamase found in Escherichia coli. CMY-20 antibiotic_resistance ARO:3002031 CMY-20 CMY-20 is a beta-lactamase found in Escherichia coli. PMID:18207348 CMY-20 CMY-21 is a beta-lactamase found in Escherichia coli. CMY-21 antibiotic_resistance ARO:3002032 CMY-21 CMY-21 is a beta-lactamase found in Escherichia coli. PMID:16716570 CMY-21 CMY-22 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-22 antibiotic_resistance ARO:3002033 CMY-22 CMY-22 CMY-23 is a beta-lactamase found in the Enterobacteriaceae family. CMY-23 antibiotic_resistance ARO:3002034 CMY-23 CMY-23 is a beta-lactamase found in the Enterobacteriaceae family. PMID:17110393 CMY-23 CMY-24 is a beta-lactamase found in the Enterobacteriaceae family. CMY-24 antibiotic_resistance ARO:3002035 CMY-24 CMY-24 is a beta-lactamase found in the Enterobacteriaceae family. PMID:17587551 CMY-24 CMY-25 is a beta-lactamase found in the Enterobacteriaceae family. CMY-25 antibiotic_resistance ARO:3002036 CMY-25 CMY-25 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19523051 CMY-25 CMY-26 is a beta-lactamase found in the Enterobacteriaceae family. CMY-26 antibiotic_resistance ARO:3002037 CMY-26 CMY-26 is a beta-lactamase found in the Enterobacteriaceae family. PMID:17720829 CMY-26 CMY-27 is a beta-lactamase found in the Enterobacteriaceae family. CMY-27 antibiotic_resistance ARO:3002038 CMY-27 CMY-27 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19523051 CMY-27 CMY-28 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-28 antibiotic_resistance ARO:3002039 CMY-28 CMY-28 CMY-29 is a beta-lactamase found in the Enterobacteriaceae family. CMY-29 antibiotic_resistance ARO:3002040 CMY-29 CMY-29 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19414570 CMY-29 CMY-30 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-30 antibiotic_resistance ARO:3002041 CMY-30 CMY-30 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. PMID:19414570 CMY-30 CMY-31 is a beta-lactamase found in the Enterobacteriaceae family. CMY-31 antibiotic_resistance ARO:3002042 CMY-31 CMY-31 is a beta-lactamase found in the Enterobacteriaceae family. PMID:18065410 CMY-31 CMY-32 is a beta-lactamase found in Escherichia coli. CMY-32 antibiotic_resistance ARO:3002043 CMY-32 CMY-32 is a beta-lactamase found in Escherichia coli. PMID:19687234 CMY-32 CMY-33 is a beta-lactamase found in Escherichia coli. CMY-33 antibiotic_resistance ARO:3002044 CMY-33 CMY-33 is a beta-lactamase found in Escherichia coli. PMID:19414578 CMY-33 CMY-34 is a beta-lactamase found in Escherichia coli. CMY-34 antibiotic_resistance ARO:3002045 CMY-34 CMY-34 is a beta-lactamase found in Escherichia coli. PMID:21820821 CMY-34 CMY-35 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-35 antibiotic_resistance ARO:3002046 CMY-35 CMY-35 CMY-36 is a beta-lactamase found in Klebsiella pneumoniae. CMY-36 antibiotic_resistance ARO:3002047 CMY-36 CMY-36 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19104021 CMY-36 CMY-37 is a beta-lactamase found in Citrobacter freundii. CMY-37 antibiotic_resistance ARO:3002048 CMY-37 CMY-37 is a beta-lactamase found in Citrobacter freundii. PMID:18619820 CMY-37 CMY-38 is a beta-lactamase found in the Enterobacteriaceae family. CMY-38 antibiotic_resistance ARO:3002049 CMY-38 CMY-38 is a beta-lactamase found in the Enterobacteriaceae family. PMID:18458126 CMY-38 CMY-39 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-39 antibiotic_resistance ARO:3002050 CMY-39 CMY-39 CMY-40 is a beta-lactamase found in the Enterobacteriaceae family. CMY-40 antibiotic_resistance ARO:3002051 CMY-40 CMY-40 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19523051 CMY-40 CMY-41 is a beta-lactamase found in the Enterobacteriaceae family. CMY-41 antibiotic_resistance ARO:3002052 CMY-41 CMY-41 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19343954 CMY-41 CMY-42 is a plasmid-borne AmpC cephalosporinase gene found in Escherichia coli. CMY-42 antibiotic_resistance ARO:3002053 CMY-42 CMY-42 is a plasmid-borne AmpC cephalosporinase gene found in Escherichia coli. PMID:21388298 CMY-42 CMY-43 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-43 antibiotic_resistance ARO:3002054 CMY-43 CMY-43 CMY-44 is a beta-lactamase found in Escherichia coli. CMY-44 antibiotic_resistance ARO:3002055 CMY-44 CMY-44 is a beta-lactamase found in Escherichia coli. PMID:19414578 CMY-44 CMY-45 is a beta-lactamase found in Proteus mirabilis. CMY-45 antibiotic_resistance ARO:3002056 CMY-45 CMY-45 is a beta-lactamase found in Proteus mirabilis. PMID:21402851 CMY-45 CMY-46 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-46 antibiotic_resistance ARO:3002057 CMY-46 CMY-46 CMY-47 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-47 antibiotic_resistance ARO:3002058 CMY-47 CMY-47 CMY-48 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-48 antibiotic_resistance ARO:3002059 CMY-48 CMY-48 CMY-49 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-49 antibiotic_resistance ARO:3002060 CMY-49 CMY-49 CMY-50 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-50 antibiotic_resistance ARO:3002061 CMY-50 CMY-50 CMY-51 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-51 antibiotic_resistance ARO:3002062 CMY-51 CMY-51 CMY-52 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. antibiotic_resistance ARO:3002063 CMY-52 CMY-53 is a beta-lactamase found in Escherichia coli. CMY-53 antibiotic_resistance ARO:3002064 CMY-53 CMY-53 is a beta-lactamase found in Escherichia coli. PMID:21820821 CMY-53 CMY-54 is a beta-lactamase found in the Enterobacteriaceae family. CMY-54 antibiotic_resistance ARO:3002065 CMY-54 CMY-54 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22956023 PMID:28665771 CMY-54 CMY-55 is a beta-lactamase found in the Enterobacteriaceae family. CMY-55 antibiotic_resistance ARO:3002066 CMY-55 CMY-55 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22956023 CMY-55 CMY-56 is a beta-lactamase found in the Enterobacteriaceae family. CMY-56 antibiotic_resistance ARO:3002067 CMY-56 CMY-56 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22956023 CMY-56 CMY-57 is a beta-lactamase found in the Enterobacteriaceae family. CMY-57 antibiotic_resistance ARO:3002068 CMY-57 CMY-57 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22956023 CMY-57 CMY-59 is a beta-lactamase found in Shigella spp. CMY-59 antibiotic_resistance ARO:3002069 CMY-59 CMY-59 is a beta-lactamase found in Shigella spp. PMID:23825726 CMY-59 CMY-99 is a beta-lactamase found in Proteus mirabilis. CMY-99 antibiotic_resistance ARO:3002070 CMY-99 CMY-99 is a beta-lactamase found in Proteus mirabilis. PMID:24165184 CMY-99 CMY-110 is a beta-lactamase found in Escherichia coli. CMY-110 antibiotic_resistance ARO:3002071 CMY-110 CMY-110 is a beta-lactamase found in Escherichia coli. PMID:24709044 CMY-110 CMY-58 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-58 antibiotic_resistance ARO:3002072 CMY-58 CMY-58 CMY-60 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-60 antibiotic_resistance ARO:3002073 CMY-60 CMY-60 CMY-61 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-61 antibiotic_resistance ARO:3002074 CMY-61 CMY-61 CMY-62 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-62 antibiotic_resistance ARO:3002075 CMY-62 CMY-62 CMY-63 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-63 antibiotic_resistance ARO:3002076 CMY-63 CMY-63 CMY-64 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-64 antibiotic_resistance ARO:3002077 CMY-64 CMY-64 CMY-65 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-65 antibiotic_resistance ARO:3002078 CMY-65 CMY-65 CMY-66 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-66 antibiotic_resistance ARO:3002079 CMY-66 CMY-66 CMY-67 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-67 antibiotic_resistance ARO:3002080 CMY-67 CMY-67 CMY-68 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-68 antibiotic_resistance ARO:3002081 CMY-68 CMY-68 CMY-69 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-69 antibiotic_resistance ARO:3002082 CMY-69 CMY-69 CMY-70 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-70 antibiotic_resistance ARO:3002083 CMY-70 CMY-70 CMY-71 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-71 antibiotic_resistance ARO:3002084 CMY-71 CMY-71 CMY-72 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-72 antibiotic_resistance ARO:3002085 CMY-72 CMY-72 CMY-73 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-73 antibiotic_resistance ARO:3002086 CMY-73 CMY-73 CMY-74 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-74 antibiotic_resistance ARO:3002087 CMY-74 CMY-74 CMY-75 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-75 antibiotic_resistance ARO:3002088 CMY-75 CMY-75 CMY-76 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-76 antibiotic_resistance ARO:3002089 CMY-76 CMY-76 CMY-77 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-77 antibiotic_resistance ARO:3002090 CMY-77 CMY-77 CMY-78 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-78 antibiotic_resistance ARO:3002091 CMY-78 CMY-78 CMY-79 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-79 antibiotic_resistance ARO:3002092 CMY-79 CMY-79 CMY-80 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-80 antibiotic_resistance ARO:3002093 CMY-80 CMY-80 CMY-81 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-81 antibiotic_resistance ARO:3002094 CMY-81 CMY-81 CMY-82 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-82 antibiotic_resistance ARO:3002095 CMY-82 CMY-82 CMY-83 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-83 antibiotic_resistance ARO:3002096 CMY-83 CMY-83 CMY-84 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-84 antibiotic_resistance ARO:3002097 CMY-84 CMY-84 CMY-85 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-85 antibiotic_resistance ARO:3002098 CMY-85 CMY-85 CMY-86 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-86 antibiotic_resistance ARO:3002099 CMY-86 CMY-86 CMY-87 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-87 antibiotic_resistance ARO:3002100 CMY-87 CMY-87 CMY-88 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. antibiotic_resistance ARO:3002101 CMY-88 CMY-89 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. CMY-89 antibiotic_resistance ARO:3002102 CMY-89 CMY-89 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. PMID:24267783 CMY-89 CMY-90 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-90 antibiotic_resistance ARO:3002103 CMY-90 CMY-90 CMY-91 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. antibiotic_resistance ARO:3002104 CMY-91 CMY-92 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. antibiotic_resistance ARO:3002105 CMY-92 CMY-93 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-93 antibiotic_resistance ARO:3002106 CMY-93 CMY-93 CMY-94 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-94 antibiotic_resistance ARO:3002107 CMY-94 CMY-94 CMY-95 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-95 antibiotic_resistance ARO:3002108 CMY-95 CMY-95 CMY-96 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016. CMY-96 antibiotic_resistance ARO:3002109 CMY-96 CMY-96 CMY-97 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 25-OCT-2012. CMY-97 antibiotic_resistance ARO:3002110 CMY-97 CMY-97 CMY-98 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-98 antibiotic_resistance ARO:3002111 CMY-98 CMY-98 CMY-100 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-100 antibiotic_resistance ARO:3002112 CMY-100 CMY-100 CMY-101 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-101 antibiotic_resistance ARO:3002113 CMY-101 CMY-101 CMY-102 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-102 antibiotic_resistance ARO:3002114 CMY-102 CMY-102 CMY-103 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-103 antibiotic_resistance ARO:3002115 CMY-103 CMY-103 CMY-104 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-104 antibiotic_resistance ARO:3002116 CMY-104 CMY-104 CMY-105 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-105 antibiotic_resistance ARO:3002117 CMY-105 CMY-105 CMY-106 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-106 antibiotic_resistance ARO:3002118 CMY-106 CMY-106 CMY-107 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016. CMY-107 antibiotic_resistance ARO:3002119 CMY-107 CMY-107 CMY-108 is a beta-lactamase present in plasmids of clinical Escherichia coli from humans and companion animals in the upper Midwestern USA . From the Lahey list of CMY beta-lactamases. CMY-108 antibiotic_resistance ARO:3002120 CMY-108 CMY-108 is a beta-lactamase present in plasmids of clinical Escherichia coli from humans and companion animals in the upper Midwestern USA . From the Lahey list of CMY beta-lactamases. PMID:24500191 CMY-108 CMY-109 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-109 antibiotic_resistance ARO:3002121 CMY-109 CMY-109 CMY-111 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-111 antibiotic_resistance ARO:3002122 CMY-111 CMY-111 CMY-112 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-112 antibiotic_resistance ARO:3002123 CMY-112 CMY-112 CMY-113 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-113 antibiotic_resistance ARO:3002124 CMY-113 CMY-113 CMY-114 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-114 antibiotic_resistance ARO:3002125 CMY-114 CMY-114 CMY-115 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-115 antibiotic_resistance ARO:3002126 CMY-115 CMY-115 CMY-116 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-116 antibiotic_resistance ARO:3002127 CMY-116 CMY-116 CMY-117 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-117 antibiotic_resistance ARO:3002128 CMY-117 CMY-117 CMY-118 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-118 antibiotic_resistance ARO:3002129 CMY-118 CMY-118 CMY-119 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. CMY-119 antibiotic_resistance ARO:3002130 CMY-119 CMY-119 CMY-120 is a beta-lactamase. From the Lahey list of CMY beta-lactamases. antibiotic_resistance ARO:3002131 CMY-120 DHA-1 is a class C beta-lactamase found in Morganella morganii and Salmonella enterica. DHA-1 antibiotic_resistance ARO:3002132 DHA-1 DHA-1 is a class C beta-lactamase found in Morganella morganii and Salmonella enterica. PMID:9736562 DHA-1 DHA-2 is a beta-lactamase found in Klebsiella pneumoniae. DHA-2 antibiotic_resistance ARO:3002133 DHA-2 DHA-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:11157909 DHA-2 DHA-3 is a beta-lactamase found in Klebsiella pneumoniae. DHA-3 antibiotic_resistance ARO:3002134 DHA-3 DHA-3 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16216104 DHA-3 DHA-6 is a beta-lactamase found in the Enterobacteriaceae family. DHA-6 antibiotic_resistance ARO:3002135 DHA-6 DHA-6 DHA-7 is a beta-lactamase found in the Enterobacteriaceae family. DHA-7 antibiotic_resistance ARO:3002136 DHA-7 DHA-7 DHA-4 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-4 antibiotic_resistance ARO:3002137 DHA-4 DHA-4 DHA-5 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-5 antibiotic_resistance ARO:3002138 DHA-5 DHA-5 DHA-8 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. antibiotic_resistance ARO:3002139 DHA-8 DHA-9 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-9 antibiotic_resistance ARO:3002140 DHA-9 DHA-9 DHA-10 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-10 antibiotic_resistance ARO:3002141 DHA-10 DHA-10 DHA-11 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. antibiotic_resistance ARO:3002142 DHA-11 DHA-12 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-12 antibiotic_resistance ARO:3002143 DHA-12 DHA-12 DHA-13 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-13 antibiotic_resistance ARO:3002144 DHA-13 DHA-13 DHA-14 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-14 antibiotic_resistance ARO:3002145 DHA-14 DHA-14 DHA-15 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-15 antibiotic_resistance ARO:3002146 DHA-15 DHA-15 DHA-16 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-16 antibiotic_resistance ARO:3002147 DHA-16 DHA-16 DHA-17 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-17 antibiotic_resistance ARO:3002148 DHA-17 DHA-17 DHA-18 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-18 antibiotic_resistance ARO:3002149 DHA-18 DHA-18 DHA-19 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-19 antibiotic_resistance ARO:3002150 DHA-19 DHA-19 DHA-20 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-20 antibiotic_resistance ARO:3002151 DHA-20 DHA-20 DHA-21 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-21 antibiotic_resistance ARO:3002152 DHA-21 DHA-21 DHA-22 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-22 antibiotic_resistance ARO:3002153 DHA-22 DHA-22 DHA-23 is a beta-lactamase. From the Lahey list of DHA beta-lactamases. DHA-23 antibiotic_resistance ARO:3002154 DHA-23 DHA-23 FOX-1 is a beta-lactamase found in Klebsiella pneumoniae. FOX-1 antibiotic_resistance ARO:3002155 FOX-1 FOX-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:7811034 FOX-1 FOX-2 is a beta-lactamase found in Escherichia coli. FOX-2 antibiotic_resistance ARO:3002156 FOX-2 FOX-2 is a beta-lactamase found in Escherichia coli. PMID:9303413 FOX-2 FOX-3 is a beta-lactamase found in Klebsiella oxytoca. FOX-3 antibiotic_resistance ARO:3002157 FOX-3 FOX-3 is a beta-lactamase found in Klebsiella oxytoca. PMID:9527810 FOX-3 FOX-4 is a beta-lactamase found in Escherichia coli. FOX-4 antibiotic_resistance ARO:3002158 FOX-4 FOX-4 is a beta-lactamase found in Escherichia coli. PMID:10952615 FOX-4 FOX-5 is a beta-lactamase found in Klebsiella pneumoniae. FOX-5 FOX-6 antibiotic_resistance ARO:3002159 FOX-5 FOX-5 is a beta-lactamase found in Klebsiella pneumoniae. PMID:11600376 FOX-5 FOX-7 is a beta-lactamase found in Klebsiella pneumoniae. FOX-7 antibiotic_resistance ARO:3002160 FOX-7 FOX-7 is a beta-lactamase found in Klebsiella pneumoniae. PMID:24088849 FOX-7 FOX-8 is a beta-lactamase found in the Enterobacteriaceae family. FOX-8 antibiotic_resistance ARO:3002161 FOX-8 FOX-8 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22956023 FOX-8 FOX-10 is a beta-lactamase. From the Lahey list of FOX beta-lactamases. FOX-10 antibiotic_resistance ARO:3002162 FOX-10 FOX-10 FOX-9 is a beta-lactamase. From the Lahey list of FOX beta-lactamases. FOX-9 antibiotic_resistance ARO:3002163 FOX-9 FOX-9 FOX-11 is a beta-lactamase. From the Lahey list of FOX beta-lactamases. antibiotic_resistance ARO:3002164 FOX-11 FOX-12 is a beta-lactamase. From the Lahey list of FOX beta-lactamases. FOX-12 antibiotic_resistance ARO:3002165 FOX-12 FOX-12 MIR-1 is a beta-lactamase found in Klebsiella pneumoniae. MIR-1 antibiotic_resistance ARO:3002166 MIR-1 MIR-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:1963529 MIR-1 MIR-4 is a beta-lactamase found in Escherichia coli. MIR-4 antibiotic_resistance ARO:3002167 MIR-4 MIR-4 is a beta-lactamase found in Escherichia coli. PMID:18781358 MIR-4 MIR-2 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-2 antibiotic_resistance ARO:3002168 MIR-2 MIR-2 MIR-3 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-3 antibiotic_resistance ARO:3002169 MIR-3 MIR-3 MIR-5 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-5 MIR-8 antibiotic_resistance ARO:3002170 MIR-5 MIR-5 MIR-6 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-6 antibiotic_resistance ARO:3002171 MIR-6 MIR-6 MIR-7 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-7 antibiotic_resistance ARO:3002172 MIR-7 MIR-7 MIR-9 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-9 antibiotic_resistance ARO:3002174 MIR-9 MIR-9 MIR-10 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-10 antibiotic_resistance ARO:3002175 MIR-10 MIR-10 MIR-11 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-11 antibiotic_resistance ARO:3002176 MIR-11 MIR-11 MIR-12 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-12 antibiotic_resistance ARO:3002177 MIR-12 MIR-12 MIR-13 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-13 antibiotic_resistance ARO:3002178 MIR-13 MIR-13 MIR-14 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-14 antibiotic_resistance ARO:3002179 MIR-14 MIR-14 MIR-15 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-15 antibiotic_resistance ARO:3002180 MIR-15 MIR-15 MIR-16 is a beta-lactamase. From the Lahey list of MIR beta-lactamases. MIR-16 antibiotic_resistance ARO:3002181 MIR-16 MIR-16 MOX-1 is a beta-lactamase found in Klebsiella pneumoniae. MOX-1 antibiotic_resistance ARO:3002182 MOX-1 MOX-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:8112596 MOX-1 MOX-2 is a beta-lactamase found in Klebsiella pneumoniae. MOX-2 antibiotic_resistance ARO:3002183 MOX-2 MOX-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:12069985 MOX-2 MOX-4 is a beta-lactamase found in Aeromonas caviae. MOX-4 antibiotic_resistance ARO:3002184 MOX-4 MOX-4 is a beta-lactamase found in Aeromonas caviae. PMID:20339022 MOX-4 MOX-6 is a beta-lactamase found in Klebsiella pneumoniae. MOX-6 antibiotic_resistance ARO:3002185 MOX-6 MOX-6 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21968366 MOX-6 MOX-3 is a beta-lactamase. From the Lahey list of MOX beta-lactamases. MOX-3 antibiotic_resistance ARO:3002186 MOX-3 MOX-3 MOX-5 is a beta-lactamase. From the Lahey list of MOX beta-lactamases. MOX-5 antibiotic_resistance ARO:3002188 MOX-5 MOX-5 MOX-7 is a beta-lactamase. From the Lahey list of MOX beta-lactamases. MOX-7 antibiotic_resistance ARO:3002189 MOX-7 MOX-7 MOX-8 is a beta-lactamase. From the Lahey list of MOX beta-lactamases. MOX-8 antibiotic_resistance ARO:3002190 MOX-8 MOX-8 MOX-9 is a beta-lactamase found in Citrobacter freundii. MOX-9 antibiotic_resistance ARO:3002191 MOX-9 MOX-9 is a beta-lactamase found in Citrobacter freundii. PMID:26126492 MOX-9 IMP-1 is a beta-lactamase found in Serratia marcescens. IMP-1 antibiotic_resistance ARO:3002192 IMP-1 IMP-1 is a beta-lactamase found in Serratia marcescens. PMID:8141584 IMP-1 IMP-2 is a beta-lactamase found in Acinetobacter baumannii. IMP-2 antibiotic_resistance ARO:3002193 IMP-2 IMP-2 is a beta-lactamase found in Acinetobacter baumannii. PMID:10770756 IMP-2 IMP-3 is a beta-lactamase found in Acinetobacter baumannii. IMP-3 met-1 antibiotic_resistance ARO:3002194 IMP-3 IMP-3 is a beta-lactamase found in Acinetobacter baumannii. PMID:10898670 IMP-3 IMP-4 is a beta-lactamase found in Acinetobacter baumannii. IMP-4 antibiotic_resistance ARO:3002195 IMP-4 IMP-4 is a beta-lactamase found in Acinetobacter baumannii. PMID:17284537 IMP-4 IMP-5 is a beta-lactamase found in Acinetobacter baumannii. IMP-5 antibiotic_resistance ARO:3002196 IMP-5 IMP-5 is a beta-lactamase found in Acinetobacter baumannii. PMID:12393197 IMP-5 IMP-6 is a beta-lactamase found in Serratia marcescens. IMP-6 antibiotic_resistance ARO:3002197 IMP-6 IMP-6 is a beta-lactamase found in Serratia marcescens. PMID:11302793 IMP-6 IMP-7 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-7 antibiotic_resistance ARO:3002198 IMP-7 IMP-7 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:11751148 IMP-7 IMP-8 is a beta-lactamase found in Klebsiella pneumoniae. IMP-47 IMP-8 antibiotic_resistance ARO:3002199 IMP-8 IMP-8 is a beta-lactamase found in Klebsiella pneumoniae. PMID:11451699 IMP-8 IMP-9 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-9 antibiotic_resistance ARO:3002200 IMP-9 IMP-9 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:16377710 IMP-9 IMP-10 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-10 antibiotic_resistance ARO:3002201 IMP-10 IMP-10 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:12019129 IMP-10 IMP-11 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-11 antibiotic_resistance ARO:3002202 IMP-11 IMP-11 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:21707466 IMP-11 IMP-12 is a beta-lactamase found in Pseudomonas putida. IMP-12 antibiotic_resistance ARO:3002203 IMP-12 IMP-12 is a beta-lactamase found in Pseudomonas putida. PMID:12709317 IMP-12 IMP-13 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-13 antibiotic_resistance ARO:3002204 IMP-13 IMP-13 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:12951335 IMP-13 IMP-14 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-14 antibiotic_resistance ARO:3002205 IMP-14 IMP-14 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:21707466 IMP-14 IMP-15 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-15 antibiotic_resistance ARO:3002206 IMP-15 IMP-15 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:18362195 IMP-15 IMP-16 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-16 antibiotic_resistance ARO:3002207 IMP-16 IMP-16 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:15561846 IMP-16 IMP-17 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. IMP-17 antibiotic_resistance ARO:3002208 IMP-17 IMP-17 IMP-18 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-18 antibiotic_resistance ARO:3002209 IMP-18 IMP-18 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:16723605 IMP-18 IMP-19 is a beta-lactamase found in Aeromonas caviae. IMP-19 antibiotic_resistance ARO:3002210 IMP-19 IMP-19 is a beta-lactamase found in Aeromonas caviae. PMID:7938180 IMP-19 IMP-20 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-20 antibiotic_resistance ARO:3002211 IMP-20 IMP-20 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:21707466 IMP-20 IMP-21 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-21 antibiotic_resistance ARO:3002212 IMP-21 IMP-21 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:21707466 IMP-21 IMP-22 is a beta-lactamase found in Pseudomonas spp. IMP-22 antibiotic_resistance ARO:3002213 IMP-22 IMP-22 is a beta-lactamase found in Pseudomonas spp. PMID:19270313 IMP-22 IMP-23 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. IMP-23 antibiotic_resistance ARO:3002214 IMP-23 IMP-23 IMP-24 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-24 antibiotic_resistance ARO:3002215 IMP-24 IMP-24 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:18804966 IMP-24 IMP-25 is a beta-lactamase found in Serratia marcescens. IMP-25 antibiotic_resistance ARO:3002216 IMP-25 IMP-25 is a beta-lactamase found in Serratia marcescens. PMID:23006757 IMP-25 IMP-26 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-26 antibiotic_resistance ARO:3002217 IMP-26 IMP-26 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:20463166 IMP-26 IMP-27 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. IMP-27 antibiotic_resistance ARO:3002218 IMP-27 IMP-27 IMP-28 is a beta-lactamase found in Klebsiella oxytoca. IMP-28 antibiotic_resistance ARO:3002219 IMP-28 IMP-28 is a beta-lactamase found in Klebsiella oxytoca. PMID:22668859 IMP-28 IMP-29 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-29 antibiotic_resistance ARO:3002220 IMP-29 IMP-29 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:22290960 IMP-29 IMP-30 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-30 antibiotic_resistance ARO:3002221 IMP-30 IMP-30 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:23836186 IMP-30 IMP-31 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. IMP-31 antibiotic_resistance ARO:3002222 IMP-31 IMP-31 IMP-32 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. IMP-32 antibiotic_resistance ARO:3002223 IMP-32 IMP-32 IMP-33 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-33 antibiotic_resistance ARO:3002224 IMP-33 IMP-33 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:24041889 IMP-33 IMP-34 is a beta-lactamase found in Klebsiella spp. IMP-34 antibiotic_resistance ARO:3002225 IMP-34 IMP-34 is a beta-lactamase found in Klebsiella spp. PMID:23541689 IMP-34 IMP-35 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-35 antibiotic_resistance ARO:3002226 IMP-35 IMP-35 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:23341129 IMP-35 IMP-36 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. antibiotic_resistance ARO:3002227 IMP-36 IMP-37 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. IMP-37 antibiotic_resistance ARO:3002228 IMP-37 IMP-37 IMP-38 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. IMP-38 antibiotic_resistance ARO:3002229 IMP-38 IMP-38 IMP-39 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. IMP-39 antibiotic_resistance ARO:3002230 IMP-39 IMP-39 IMP-40 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-40 antibiotic_resistance ARO:3002231 IMP-40 IMP-40 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:23536409 IMP-40 IMP-41 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-41 antibiotic_resistance ARO:3002232 IMP-41 IMP-41 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:23536409 IMP-41 IMP-42 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-42 antibiotic_resistance ARO:3002233 IMP-42 IMP-42 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:23536409 IMP-42 IMP-43 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-43 antibiotic_resistance ARO:3002234 IMP-43 IMP-43 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:23836174 IMP-43 IMP-44 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-44 antibiotic_resistance ARO:3002235 IMP-44 IMP-44 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:23836174 IMP-44 IMP-45 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-45 antibiotic_resistance ARO:3002236 IMP-45 IMP-45 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:24777897 IMP-45 IMP-46 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. IMP-46 antibiotic_resistance ARO:3002237 IMP-46 IMP-46 IMP-48 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. IMP-48 antibiotic_resistance ARO:3002239 IMP-48 IMP-48 CARB-1 is a beta-lactamase found in Pseudomonas aeruginosa. CARB-1 PSE-4, BlaP1a antibiotic_resistance ARO:3002240 CARB-1 CARB-1 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:11959558 CARB-1 CARB-2 is a beta-lactamase found in Pseudomonas aeruginosa. CARB-2 PSE-1, BlaP1b, PSE-3 antibiotic_resistance ARO:3002241 CARB-2 CARB-2 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:1804019 CARB-2 CARB-3 is a beta-lactamase found in Pseudomonas aeruginosa. CARB-3 antibiotic_resistance ARO:3002242 CARB-3 CARB-3 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:1650733 CARB-3 CARB-4 is a beta-lactamase found in Pseudomonas aeruginosa. BlaP3 CARB-4 antibiotic_resistance ARO:3002243 CARB-4 CARB-4 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:9687391 CARB-4 CARB-5 is a beta-lactamase found in Acinetobacter calcoaceticus. BlaRTG-2 CARB-5 antibiotic_resistance ARO:3002244 CARB-5 CARB-5 is a beta-lactamase found in Acinetobacter calcoaceticus. PMID:10722515 CARB-5 CARB-6 is a beta-lactamase found in Vibrio cholerae. CARB-6 antibiotic_resistance ARO:3002245 CARB-6 CARB-6 is a beta-lactamase found in Vibrio cholerae. PMID:9925522 CARB-6 CARB-7 is a beta-lactamase found in Vibrio cholerae. CARB-11, PSE-5 CARB-7 antibiotic_resistance ARO:3002246 CARB-7 CARB-7 is a beta-lactamase found in Vibrio cholerae. PMID:12069969 CARB-7 CARB-8 is a beta-lactamase found in Oligella urethralis. BlaRTG-3 CARB-8 antibiotic_resistance ARO:3002247 CARB-8 CARB-8 is a beta-lactamase found in Oligella urethralis. PMID:12709319 CARB-8 CARB-9 is a beta-lactamase found in Vibrio cholerae. CARB-9 antibiotic_resistance ARO:3002248 CARB-9 CARB-9 is a beta-lactamase found in Vibrio cholerae. PMID:15388476 CARB-9 CARB-10 is a beta-lactamase found in Acinetobacter baumannii. BlaRTG-4 CARB-10 antibiotic_resistance ARO:3002249 CARB-10 CARB-10 is a beta-lactamase found in Acinetobacter baumannii. PMID:19380596 CARB-10 CARB-12 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. CARB-12 antibiotic_resistance ARO:3002250 CARB-12 CARB-12 CARB-13 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. antibiotic_resistance ARO:3002251 CARB-13 CARB-14 is a beta-lactamase found in Acinetobacter baumannii. BlaRTG-5 CARB-14 antibiotic_resistance ARO:3002252 CARB-14 CARB-14 is a beta-lactamase found in Acinetobacter baumannii. PMID:22633451 CARB-14 CARB-15 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. antibiotic_resistance ARO:3002253 CARB-15 CARB-17 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. CARB-17 antibiotic_resistance ARO:3002254 CARB-17 CARB-17 CARB-16 is a beta-lactamase. From the Lahey list of IMP beta-lactamases. BlaRTG-6 CARB-16 antibiotic_resistance ARO:3002255 CARB-16 CARB-16 IND-1 is a beta-lactamase found in Chryseobacterium indologenes. IND-1 antibiotic_resistance ARO:3002256 IND-1 IND-1 is a beta-lactamase found in Chryseobacterium indologenes. PMID:10077836 IND-1 IND-2 is a beta-lactamase found in Chryseobacterium indologenes. IND-2 antibiotic_resistance ARO:3002257 IND-2 IND-2 is a beta-lactamase found in Chryseobacterium indologenes. PMID:11036018 IND-2 IND-2a is a beta-lactamase found in Chryseobacterium indologenes. IND-13 IND-2a antibiotic_resistance ARO:3002258 IND-2a IND-2a is a beta-lactamase found in Chryseobacterium indologenes. PMID:11036018 IND-2a IND-3 is a beta-lactamase found in Chryseobacterium indologenes. IND-3 antibiotic_resistance ARO:3002259 IND-3 IND-3 is a beta-lactamase found in Chryseobacterium indologenes. PMID:11036018 IND-3 IND-4 is a beta-lactamase found in Chryseobacterium indologenes. IND-4 antibiotic_resistance ARO:3002260 IND-4 IND-4 is a beta-lactamase found in Chryseobacterium indologenes. PMID:11036018 IND-4 IND-5 is a beta-lactamase found in Chryseobacterium indologenes. IND-5 antibiotic_resistance ARO:3002261 IND-5 IND-5 is a beta-lactamase found in Chryseobacterium indologenes. PMID:17470648 IND-5 IND-6 is a beta-lactamase found in Chryseobacterium indologenes. IND-6 antibiotic_resistance ARO:3002262 IND-6 IND-6 is a beta-lactamase found in Chryseobacterium indologenes. PMID:19651915 IND-6 IND-7 is a beta-lactamase found in Chryseobacterium indologenes. IND-7 antibiotic_resistance ARO:3002263 IND-7 IND-7 is a beta-lactamase found in Chryseobacterium indologenes. PMID:20305272 IND-7 IND-8 is a beta-lactamase found in Escherichia coli. IND-8 antibiotic_resistance ARO:3002264 IND-8 IND-8 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-8 IND-9 is a beta-lactamase found in Escherichia coli. IND-9 antibiotic_resistance ARO:3002265 IND-9 IND-9 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-9 IND-10 is a beta-lactamase found in Escherichia coli. IND-10 antibiotic_resistance ARO:3002266 IND-10 IND-10 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-10 IND-11 is a beta-lactamase found in Escherichia coli. IND-11 antibiotic_resistance ARO:3002267 IND-11 IND-11 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-11 IND-12 is a beta-lactamase found in Escherichia coli. IND-12 antibiotic_resistance ARO:3002268 IND-12 IND-12 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-12 IND-14 is a beta-lactamase found in Escherichia coli. IND-14 antibiotic_resistance ARO:3002269 IND-14 IND-14 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-14 IND-15 is a beta-lactamase found in Escherichia coli. IND-15 antibiotic_resistance ARO:3002270 IND-15 IND-15 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-15 VIM-1 is a beta-lactamase found in Pseudomonas spp. VIM-1 antibiotic_resistance ARO:3002271 VIM-1 VIM-1 is a beta-lactamase found in Pseudomonas spp. PMID:18804966 VIM-1 VIM-2 is a beta-lactamase found in Pseudomonas spp. PDB:1KO2 VIM-2 antibiotic_resistance ARO:3002272 VIM-2 VIM-2 is a beta-lactamase found in Pseudomonas spp. PMID:18804966 VIM-2 VIM-3 is a beta-lactamase found in Pseudomonas spp. VIM-3 antibiotic_resistance ARO:3002273 VIM-3 VIM-3 is a beta-lactamase found in Pseudomonas spp. PMID:11451678 VIM-3 VIM-4 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-4 antibiotic_resistance ARO:3002274 VIM-4 VIM-4 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:12435718 VIM-4 VIM-5 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-5 antibiotic_resistance ARO:3002275 VIM-5 VIM-5 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:15190017 VIM-5 VIM-6 is a beta-lactamase found in Pseudomonas spp. VIM-6 antibiotic_resistance ARO:3002276 VIM-6 VIM-6 is a beta-lactamase found in Pseudomonas spp. PMID:15155248 VIM-6 VIM-7 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-7 antibiotic_resistance ARO:3002277 VIM-7 VIM-7 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:14693560 VIM-7 VIM-8 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-8 antibiotic_resistance ARO:3002278 VIM-8 VIM-8 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:15528701 VIM-8 VIM-9 is a beta-lactamase found in Pseudomonas spp. VIM-9 antibiotic_resistance ARO:3002279 VIM-9 VIM-9 is a beta-lactamase found in Pseudomonas spp. PMID:18819973 VIM-9 VIM-10 is a beta-lactamase found in Pseudomonas spp. VIM-10 antibiotic_resistance ARO:3002280 VIM-10 VIM-10 is a beta-lactamase found in Pseudomonas spp. PMID:18819973 VIM-10 VIM-11 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-11 antibiotic_resistance ARO:3002281 VIM-11 VIM-11 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:15616342 VIM-11 VIM-12 is a beta-lactamase found in Klebsiella pneumoniae. VIM-12 antibiotic_resistance ARO:3002282 VIM-12 VIM-12 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304191 VIM-12 VIM-13 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-13 antibiotic_resistance ARO:3002283 VIM-13 VIM-13 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:18644957 VIM-13 VIM-14 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-14 antibiotic_resistance ARO:3002284 VIM-14 VIM-14 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:21521413 VIM-14 VIM-15 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-15 antibiotic_resistance ARO:3002285 VIM-15 VIM-15 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:18519714 VIM-15 VIM-16 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-16 antibiotic_resistance ARO:3002286 VIM-16 VIM-16 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:18519714 VIM-16 VIM-17 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-17 antibiotic_resistance ARO:3002287 VIM-17 VIM-17 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19164147 VIM-17 VIM-18 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-18 antibiotic_resistance ARO:3002288 VIM-18 VIM-18 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19114677 VIM-18 VIM-19 is a beta-lactamase found in the Enterobacteriaceae family. VIM-19 antibiotic_resistance ARO:3002289 VIM-19 VIM-19 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19917750 VIM-19 VIM-20 is a beta-lactamase. From the Lahey list of VIM beta-lactamases. VIM-20 antibiotic_resistance ARO:3002290 VIM-20 VIM-20 VIM-21 is a beta-lactamase. From the Lahey list of VIM beta-lactamases. antibiotic_resistance ARO:3002291 VIM-21 VIM-22 is a beta-lactamase. From the Lahey list of VIM beta-lactamases. antibiotic_resistance ARO:3002292 VIM-22 VIM-23 is a beta-lactamase found in Enterobacter cloacae. VIM-23 antibiotic_resistance ARO:3002293 VIM-23 VIM-23 is a beta-lactamase found in Enterobacter cloacae. PMID:20961909 VIM-23 VIM-24 is a beta-lactamase found in Klebsiella pneumoniae. VIM-24 antibiotic_resistance ARO:3002294 VIM-24 VIM-24 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21282438 VIM-24 VIM-25 is a beta-lactamase. From the Lahey list of VIM beta-lactamases. VIM-25 antibiotic_resistance ARO:3002295 VIM-25 VIM-25 VIM-26 is a beta-lactamase. From the Lahey list of VIM beta-lactamases. VIM-26 antibiotic_resistance ARO:3002296 VIM-26 VIM-26 VIM-27 is a beta-lactamase found in Klebsiella pneumoniae. VIM-27 antibiotic_resistance ARO:3002297 VIM-27 VIM-27 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21518835 VIM-27 VIM-28 is a beta-lactamase. From the Lahey list of VIM beta-lactamases. VIM-28 antibiotic_resistance ARO:3002298 VIM-28 VIM-28 VIM-29 is a beta-lactamase found in the Enterobacteriaceae family. VIM-29 antibiotic_resistance ARO:3002299 VIM-29 VIM-29 is a beta-lactamase found in the Enterobacteriaceae family. PMID:23954421 VIM-29 VIM-30 is a beta-lactamase found in the Enterobacteriaceae family. VIM-30 antibiotic_resistance ARO:3002300 VIM-30 VIM-30 is a beta-lactamase found in the Enterobacteriaceae family. PMID:23658259 VIM-30 VIM-31 is a beta-lactamase found in Enterobacter cloacae. VIM-31 antibiotic_resistance ARO:3002301 VIM-31 VIM-31 is a beta-lactamase found in Enterobacter cloacae. PMID:22391550 VIM-31 VIM-32 is a beta-lactamase. From the Lahey list of VIM beta-lactamases. VIM-32 antibiotic_resistance ARO:3002302 VIM-32 VIM-32 VIM-33 is a beta-lactamase found in Klebsiella pneumoniae. VIM-33 antibiotic_resistance ARO:3002303 VIM-33 VIM-33 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23070171 VIM-33 VIM-34 is a beta-lactamase found in Klebsiella pneumoniae. VIM-34 antibiotic_resistance ARO:3002304 VIM-34 VIM-34 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23934739 VIM-34 VIM-35 is a beta-lactamase. From the Lahey list of VIM beta-lactamases. VIM-35 antibiotic_resistance ARO:3002305 VIM-35 VIM-35 VIM-36 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-36 antibiotic_resistance ARO:3002306 VIM-36 VIM-36 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:24603963 VIM-36 VIM-37 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-37 antibiotic_resistance ARO:3002307 VIM-37 VIM-37 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:24603963 VIM-37 VIM-38 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-38 antibiotic_resistance ARO:3002308 VIM-38 VIM-38 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:24428980 VIM-38 VIM-39 is a beta-lactamase. From the Lahey list of VIM beta-lactamases. VIM-39 antibiotic_resistance ARO:3002309 VIM-39 VIM-39 VIM-40 is a beta-lactamase. From the Lahey list of VIM beta-lactamases. VIM-40 antibiotic_resistance ARO:3002310 VIM-40 VIM-40 VIM-41 is a beta-lactamase. From the Lahey list of VIM beta-lactamases. VIM-41 antibiotic_resistance ARO:3002311 VIM-41 VIM-41 KPC-2 is a beta-lactamase found in Klebsiella pneumoniae and Pseudomonas aeruginosa. PDB:2OV5 KPC-1 KPC-2 antibiotic_resistance ARO:3002312 KPC-2 KPC-2 is a beta-lactamase found in Klebsiella pneumoniae and Pseudomonas aeruginosa. PMID:12615876 PMID:17261621 KPC-2 KPC-3 is a beta-lactamase found in Klebsiella pneumoniae. KPC-3 antibiotic_resistance ARO:3002313 KPC-3 KPC-3 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19015357 KPC-3 KPC-4 is a beta-lactamase found in Klebsiella pneumoniae. KPC-4 antibiotic_resistance ARO:3002314 KPC-4 KPC-4 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19015357 KPC-4 KPC-5 is a beta-lactamase found in Klebsiella pneumoniae and Pseudomonas aeruginosa. KPC-5 antibiotic_resistance ARO:3002315 KPC-5 KPC-5 is a beta-lactamase found in Klebsiella pneumoniae and Pseudomonas aeruginosa. PMID:19015357 KPC-5 KPC-6 is a beta-lactamase found in Klebsiella pneumoniae. KPC-6 antibiotic_resistance ARO:3002316 KPC-6 KPC-6 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22908150 KPC-6 KPC-7 is a beta-lactamase found in Klebsiella pneumoniae. KPC-7 antibiotic_resistance ARO:3002317 KPC-7 KPC-7 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19036932 KPC-7 KPC-8 is a beta-lactamase found in Klebsiella pneumoniae. KPC-8 antibiotic_resistance ARO:3002318 KPC-8 KPC-8 is a beta-lactamase found in Klebsiella pneumoniae. PMID:20334553 KPC-8 KPC-9 is a beta-lactamase found in Klebsiella pneumoniae. KPC-9 antibiotic_resistance ARO:3002319 KPC-9 KPC-9 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22964247 KPC-9 KPC-10 is a beta-lactamase found in Klebsiella pneumoniae. KPC-10 antibiotic_resistance ARO:3002320 KPC-10 KPC-10 is a beta-lactamase found in Klebsiella pneumoniae. PMID:20038618 KPC-10 KPC-11 is a beta-lactamase found in Klebsiella pneumoniae. KPC-11 antibiotic_resistance ARO:3002321 KPC-11 KPC-11 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22322349 KPC-11 KPC-12 is a beta-lactamase. From the Lahey list of KPC beta-lactamases. KPC-12 antibiotic_resistance ARO:3002322 KPC-12 KPC-12 KPC-13 is a beta-lactamase. From the Lahey list of KPC beta-lactamases. KPC-13 antibiotic_resistance ARO:3002323 KPC-13 KPC-13 KPC-14 is a beta-lactamase. From the Lahey list of KPC beta-lactamases. KPC-14 antibiotic_resistance ARO:3002324 KPC-14 KPC-14 KPC-15 is a beta-lactamase. From the Lahey list of KPC beta-lactamases. KPC-15 antibiotic_resistance ARO:3002325 KPC-15 KPC-15 KPC-16 is a beta-lactamase. From the Lahey list of KPC beta-lactamases. KPC-16 antibiotic_resistance ARO:3002326 KPC-16 KPC-16 KPC-17 is a beta-lactamase. From the Lahey list of KPC beta-lactamases. KPC-17 antibiotic_resistance ARO:3002327 KPC-17 KPC-17 KPC-18 is a beta-lactamase. From the Lahey list of KPC beta-lactamases. KPC-18 antibiotic_resistance ARO:3002328 KPC-18 KPC-18 is a beta-lactamase. From the Lahey list of KPC beta-lactamases. PMID:26719440 KPC-18 KPC-19 is a beta-lactamase. From the Lahey list of KPC beta-lactamases. KPC-19 antibiotic_resistance ARO:3002329 KPC-19 KPC-19 GES-1 is a beta-lactamase found in Klebsiella pneumoniae. GES-1 antibiotic_resistance ARO:3002330 GES-1 GES-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:10681329 GES-1 GES-2 is a beta-lactamase found in Pseudomonas aeruginosa. GES-2 antibiotic_resistance ARO:3002331 GES-2 GES-2 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:11502535 GES-2 GES-3 is a beta-lactamase found in Klebsiella pneumoniae. GES-3 antibiotic_resistance ARO:3002332 GES-3 GES-3 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15155185 GES-3 GES-4 is a beta-lactamase found in Klebsiella pneumoniae. GES-4 antibiotic_resistance ARO:3002333 GES-4 GES-4 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15273099 GES-4 GES-5 is a beta-lactamase found in the Enterobacteriaceae family. GES-5 antibiotic_resistance ARO:3002334 GES-5 GES-5 is a beta-lactamase found in the Enterobacteriaceae family. PMID:15135524 GES-5 GES-6 is a beta-lactamase found in the Enterobacteriaceae family. GES-6 antibiotic_resistance ARO:3002335 GES-6 GES-6 is a beta-lactamase found in the Enterobacteriaceae family. PMID:15135524 GES-6 GES-7 is a beta-lactamase found in Enterobacter cloacae. GES-7 IBC-1 antibiotic_resistance ARO:3002336 GES-7 GES-7 is a beta-lactamase found in Enterobacter cloacae. PMID:10952563 GES-7 GES-8 is a beta-lactamase found in Pseudomonas aeruginosa. GES-8 IBC-2 antibiotic_resistance ARO:3002337 GES-8 GES-8 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:11679551 GES-8 GES-9 is a beta-lactamase found in Pseudomonas aeruginosa. GES-9 antibiotic_resistance ARO:3002338 GES-9 GES-9 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:16048994 GES-9 GES-10 is a beta-lactamase. From the Lahey list of GES beta-lactamases. GES-10 antibiotic_resistance ARO:3002339 GES-10 GES-10 GES-11 is a beta-lactamase found in Acinetobacter baumannii. GES-11 antibiotic_resistance ARO:3002340 GES-11 GES-11 is a beta-lactamase found in Acinetobacter baumannii. PMID:19451292 GES-11 GES-12 is a beta-lactamase found in Acinetobacter baumannii. GES-12 antibiotic_resistance ARO:3002341 GES-12 GES-12 is a beta-lactamase found in Acinetobacter baumannii. PMID:20805394 GES-12 GES-13 is a beta-lactamase found in Pseudomonas aeruginosa. GES-13 antibiotic_resistance ARO:3002342 GES-13 GES-13 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:20065056 GES-13 GES-14 is a beta-lactamase found in Acinetobacter baumannii. GES-14 antibiotic_resistance ARO:3002343 GES-14 GES-14 is a beta-lactamase found in Acinetobacter baumannii. PMID:20805394 GES-14 GES-15 is a beta-lactamase. From the Lahey list of GES beta-lactamases. GES-15 antibiotic_resistance ARO:3002344 GES-15 GES-15 GES-16 is a beta-lactamase. From the Lahey list of GES beta-lactamases. GES-16 antibiotic_resistance ARO:3002345 GES-16 GES-16 GES-17 is a beta-lactamase. From the Lahey list of GES beta-lactamases. GES-17 antibiotic_resistance ARO:3002346 GES-17 GES-17 GES-18 is a beta-lactamase found in Pseudomonas aeruginosa. GES-18 antibiotic_resistance ARO:3002347 GES-18 GES-18 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:23114760 GES-18 GES-19 is a beta-lactamase found in the Enterobacteriaceae family. GES-19 antibiotic_resistance ARO:3002348 GES-19 GES-19 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22526300 GES-19 GES-20 is a beta-lactamase found in the Enterobacteriaceae family. GES-20 antibiotic_resistance ARO:3002349 GES-20 GES-20 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22526300 GES-20 GES-21 is a beta-lactamase. From the Lahey list of GES beta-lactamases. GES-21 antibiotic_resistance ARO:3002350 GES-21 GES-21 GES-22 is a beta-lactamase. From the Lahey list of GES beta-lactamases. GES-22 antibiotic_resistance ARO:3002351 GES-22 GES-22 GES-23 is a beta-lactamase. From the Lahey list of GES beta-lactamases. GES-23 antibiotic_resistance ARO:3002352 GES-23 GES-23 GES-24 is a beta-lactamase. From the Lahey list of GES beta-lactamases. GES-24 antibiotic_resistance ARO:3002353 GES-24 GES-24 NDM-3 is a beta-lactamase found in the Enterobacteriaceae family. NDM-3 antibiotic_resistance ARO:3002354 NDM-3 NDM-3 is a beta-lactamase found in the Enterobacteriaceae family. PMID:23330550 NDM-3 NDM-4 is a beta-lactamase found in Escherichia coli. NDM-4 antibiotic_resistance ARO:3002355 NDM-4 NDM-4 is a beta-lactamase found in Escherichia coli. PMID:22252797 NDM-4 NDM-6 is a beta-lactamase found in the Enterobacteriaceae family. NDM-6 antibiotic_resistance ARO:3002356 NDM-6 NDM-6 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22526013 NDM-6 NDM-7 is a beta-lactamase found in Escherichia coli. NDM-7 antibiotic_resistance ARO:3002357 NDM-7 NDM-7 is a beta-lactamase found in Escherichia coli. PMID:23557929 NDM-7 NDM-8 is a beta-lactamase found in Escherichia coli. NDM-8 antibiotic_resistance ARO:3002358 NDM-8 NDM-8 is a beta-lactamase found in Escherichia coli. PMID:23459485 NDM-8 NDM-9 is a beta-lactamase found in Klebsiella pneumoniae. NDM-9 antibiotic_resistance ARO:3002359 NDM-9 NDM-9 is a beta-lactamase found in Klebsiella pneumoniae. PMID:24913967 NDM-9 NDM-10 is a beta-lactamase. From the Lahey list of NDM beta-lactamases. NDM-10 antibiotic_resistance ARO:3002360 NDM-10 NDM-10 NDM-11 is a beta-lactamase. From the Lahey list of NDM beta-lactamases. NDM-11 antibiotic_resistance ARO:3002361 NDM-11 NDM-11 is a beta-lactamase. From the Lahey list of NDM beta-lactamases. PMID:29656053 NDM-11 NDM-12 is a beta-lactamase found in Escherichia coli. NDM-12 antibiotic_resistance ARO:3002362 NDM-12 NDM-12 is a beta-lactamase found in Escherichia coli. PMID:25092693 NDM-12 PER-1 is a beta-lactamase found in Pseudomonas aeruginosa. PER-1 antibiotic_resistance ARO:3002363 PER-1 PER-1 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:8141562 PER-1 PER-2 is a beta-lactamase found in Salmonella typhimurium. PER-2 antibiotic_resistance ARO:3002364 PER-2 PER-2 is a beta-lactamase found in Salmonella typhimurium. PMID:8851581 PER-2 PER-3 is a beta-lactamase found in Aeromonas spp. PER-3 antibiotic_resistance ARO:3002365 PER-3 PER-3 is a beta-lactamase found in Aeromonas spp. PMID:21968366 PER-3 PER-4 is a beta-lactamase. From the Lahey list of PER beta-lactamases. PER-4 antibiotic_resistance ARO:3002366 PER-4 PER-4 PER-5 is a beta-lactamase found in the Enterobacteriaceae family. PER-5 antibiotic_resistance ARO:3002367 PER-5 PER-5 is a beta-lactamase found in the Enterobacteriaceae family. PMID:23284886 PER-5 PER-6 is a beta-lactamase found in Aeromonas allosaccharophila. PER-6 antibiotic_resistance ARO:3002368 PER-6 PER-6 is a beta-lactamase found in Aeromonas allosaccharophila. PMID:20145085 PER-6 PER-7 is a beta-lactamase found in Acinetobacter baumannii. PER-7 antibiotic_resistance ARO:3002369 PER-7 PER-7 is a beta-lactamase found in Acinetobacter baumannii. PMID:21383087 PER-7 VEB-1 is a beta-lactamase found in Escherichia coli and Pseudomonas aeruginosa. VEB-1 antibiotic_resistance ARO:3002370 VEB-1 VEB-1 is a beta-lactamase found in Escherichia coli and Pseudomonas aeruginosa. PMID:10049269 PMID:10427724 VEB-1 VEB-2 is a beta-lactamase found in Pseudomonas aeruginosa. VEB-2 antibiotic_resistance ARO:3002371 VEB-2 VEB-2 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:11807680 VEB-2 VEB-3 is a beta-lactamase found in Enterobacter cloacae. VEB-3 antibiotic_resistance ARO:3002372 VEB-3 VEB-3 is a beta-lactamase found in Enterobacter cloacae. PMID:15695687 VEB-3 VEB-4 is a beta-lactamase found in Proteus mirabilis. VEB-4 antibiotic_resistance ARO:3002373 VEB-4 VEB-4 is a beta-lactamase found in Proteus mirabilis. PMID:18292096 VEB-4 VEB-6 is a beta-lactamase found in Proteus mirabilis. VEB-6 antibiotic_resistance ARO:3002374 VEB-6 VEB-6 is a beta-lactamase found in Proteus mirabilis. PMID:18025117 VEB-6 VEB-5 is a beta-lactamase. From the Lahey list of VEB beta-lactamases. VEB-5 antibiotic_resistance ARO:3002375 VEB-5 VEB-5 VEB-7 is a beta-lactamase. From the Lahey list of VEB beta-lactamases. VEB-7 antibiotic_resistance ARO:3002376 VEB-7 VEB-7 VEB-8 is a beta-lactamase. From the Lahey list of VEB beta-lactamases. VEB-8 antibiotic_resistance ARO:3002377 VEB-8 VEB-8 VEB-9 is a beta-lactamase. From the Lahey list of VEB beta-lactamases. VEB-1a VEB-9 antibiotic_resistance ARO:3002378 VEB-9 VEB-9 SME-1 is a beta-lactamase found in Serratia marcescens. SME-1 antibiotic_resistance ARO:3002379 SME-1 SME-1 is a beta-lactamase found in Serratia marcescens. PMID:8092824 SME-1 SME-2 is a beta-lactamase found in Serratia marcescens. SME-2 antibiotic_resistance ARO:3002380 SME-2 SME-2 is a beta-lactamase found in Serratia marcescens. PMID:11036019 SME-2 SME-3 is a beta-lactamase found in Serratia marcescens. SME-3 antibiotic_resistance ARO:3002381 SME-3 SME-3 is a beta-lactamase found in Serratia marcescens. PMID:17005839 SME-3 SME-4 is a beta-lactamase. From the Lahey list of SME beta-lactamases. SME-4 antibiotic_resistance ARO:3002382 SME-4 SME-4 SME-5 is a beta-lactamase. From the Lahey list of SME beta-lactamases. SME-5 antibiotic_resistance ARO:3002383 SME-5 SME-5 BEL beta-lactamases are class A expanded-spectrum beta-lactamases that are inhibited by clavulanic acid. They are chromosomally encoded and hydrolyze most cephalosporins and aztreonam. antibiotic_resistance ARO:3002384 BEL beta-lactamase BEL beta-lactamases are class A expanded-spectrum beta-lactamases that are inhibited by clavulanic acid. They are chromosomally encoded and hydrolyze most cephalosporins and aztreonam. PMID:16127048 BEL-1 is a beta-lactamase found in Pseudomonas aeruginosa. BEL-1 antibiotic_resistance ARO:3002385 BEL-1 BEL-1 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:16127048 BEL-1 BEL-2 is a beta-lactamase found in Pseudomonas aeruginosa. BEL-2 antibiotic_resistance ARO:3002386 BEL-2 BEL-2 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19884378 BEL-2 BEL-3 is a beta-lactamase found in Pseudomonas aeruginosa. BEL-3 antibiotic_resistance ARO:3002387 BEL-3 BEL-3 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19933793 BEL-3 OXY beta-lactamases are chromosomal class A beta-lactamases that are found in Klebsiella oxytoca. At constitutive low levels, OXY beta-lactamases confer resistance to aminopenicillins and carboxypenicillins. At high induced levels, OXY beta-lactamases confer resistance to penicillins, cephalosporins and aztreonam. K1 KOXY antibiotic_resistance ARO:3002388 OXY beta-lactamase OXY beta-lactamases are chromosomal class A beta-lactamases that are found in Klebsiella oxytoca. At constitutive low levels, OXY beta-lactamases confer resistance to aminopenicillins and carboxypenicillins. At high induced levels, OXY beta-lactamases confer resistance to penicillins, cephalosporins and aztreonam. PMID:23090395 OXY-1-1 is a beta-lactamase found in Klebsiella oxytoca. OXY-1-1 OXY-1-7 antibiotic_resistance ARO:3002389 OXY-1-1 OXY-1-1 is a beta-lactamase found in Klebsiella oxytoca. PMID:23090395 OXY-1-1 OXY-1-2 is a beta-lactamase found in Klebsiella oxytoca. OXY-1-2 OXY-1-5 antibiotic_resistance ARO:3002390 OXY-1-2 OXY-1-2 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-1-2 OXY-1-3 is a beta-lactamase found in Klebsiella oxytoca. OXY-1-3 antibiotic_resistance ARO:3002391 OXY-1-3 OXY-1-3 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-1-3 OXY-1-4 is a beta-lactamase found in Klebsiella oxytoca. OXY-1-4 antibiotic_resistance ARO:3002392 OXY-1-4 OXY-1-4 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-1-4 OXY-1-6 is a beta-lactamase found in Klebsiella oxytoca. OXY-1-6 antibiotic_resistance ARO:3002394 OXY-1-6 OXY-1-6 is a beta-lactamase found in Klebsiella oxytoca. PMID:10223957 OXY-1-6 OXY-2-1 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-1 antibiotic_resistance ARO:3002396 OXY-2-1 OXY-2-1 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-2-1 OXY-2-2 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-2 antibiotic_resistance ARO:3002397 OXY-2-2 OXY-2-2 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-2-2 OXY-2-3 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-3 antibiotic_resistance ARO:3002398 OXY-2-3 OXY-2-3 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-2-3 OXY-2-4 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-4 antibiotic_resistance ARO:3002399 OXY-2-4 OXY-2-4 is a beta-lactamase found in Klebsiella oxytoca. PMID:10223957 OXY-2-4 OXY-2-5 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-5 antibiotic_resistance ARO:3002400 OXY-2-5 OXY-2-5 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-2-5 OXY-2-6 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-6 antibiotic_resistance ARO:3002401 OXY-2-6 OXY-2-6 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-2-6 OXY-2-7 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-7 antibiotic_resistance ARO:3002402 OXY-2-7 OXY-2-7 is a beta-lactamase found in Klebsiella oxytoca. PMID:7574532 OXY-2-7 OXY-2-8 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-8 antibiotic_resistance ARO:3002403 OXY-2-8 OXY-2-8 is a beta-lactamase found in Klebsiella oxytoca. PMID:12019142 OXY-2-8 OXY-2-9 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-9 antibiotic_resistance ARO:3002404 OXY-2-9 OXY-2-9 is a beta-lactamase found in Klebsiella oxytoca. PMID:21555768 OXY-2-9 OXY-2-10 is a beta-lactamase. From the Pasteur Institute (Genopole) list of OXY beta-lactamases. OXY-2-10 antibiotic_resistance ARO:3002405 OXY-2-10 OXY-2-10 OXY-2-11 is a beta-lactamase. From the Pasteur Institute (Genopole) list of OXY beta-lactamases. OXY-2-11 antibiotic_resistance ARO:3002406 OXY-2-11 OXY-2-11 OXY-2-12 is a beta-lactamase. From the Pasteur Institute (Genopole) list of OXY beta-lactamases. OXY-2-12 antibiotic_resistance ARO:3002407 OXY-2-12 OXY-2-12 OXY-2-13 is a beta-lactamase. From the Pasteur Institute (Genopole) list of OXY beta-lactamases. OXY-2-13 antibiotic_resistance ARO:3002408 OXY-2-13 OXY-2-13 OXY-3-1 is a beta-lactamase found in Klebsiella oxytoca. OXY-3-1 antibiotic_resistance ARO:3002409 OXY-3-1 OXY-3-1 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-3-1 OXY-4-1 is a beta-lactamase found in Klebsiella oxytoca. OXY-4-1 antibiotic_resistance ARO:3002410 OXY-4-1 OXY-4-1 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-4-1 OXY-5-1 is a beta-lactamase found in Klebsiella oxytoca. OXY-5-1 antibiotic_resistance ARO:3002411 OXY-5-1 OXY-5-1 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-5-1 OXY-5-2 is a beta-lactamase found in Klebsiella oxytoca. OXY-5-2 antibiotic_resistance ARO:3002412 OXY-5-2 OXY-5-2 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-5-2 OXY-6-1 is a beta-lactamase found in Klebsiella oxytoca. OXY-6-1 antibiotic_resistance ARO:3002413 OXY-6-1 OXY-6-1 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-6-1 OXY-6-2 is a beta-lactamase found in Klebsiella oxytoca. OXY-6-2 antibiotic_resistance ARO:3002414 OXY-6-2 OXY-6-2 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-6-2 OXY-6-3 is a beta-lactamase found in Klebsiella oxytoca. OXY-6-3 antibiotic_resistance ARO:3002415 OXY-6-3 OXY-6-3 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-6-3 OXY-6-4 is a beta-lactamase found in Klebsiella oxytoca. OXY-6-4 antibiotic_resistance ARO:3002416 OXY-6-4 OXY-6-4 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-6-4 OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. antibiotic_resistance ARO:3002417 OKP beta-lactamase OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. PMID:16304190 PMID:22143810 OKP-A-1 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-1 antibiotic_resistance ARO:3002418 OKP-A-1 OKP-A-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-1 OKP-A-2 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-2 antibiotic_resistance ARO:3002419 OKP-A-2 OKP-A-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-2 OKP-A-3 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-3 antibiotic_resistance ARO:3002420 OKP-A-3 OKP-A-3 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-3 OKP-A-4 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-4 antibiotic_resistance ARO:3002421 OKP-A-4 OKP-A-4 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-4 OKP-A-5 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-5 antibiotic_resistance ARO:3002422 OKP-A-5 OKP-A-5 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-5 OKP-A-6 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-6 antibiotic_resistance ARO:3002423 OKP-A-6 OKP-A-6 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-6 OKP-A-7 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-7 antibiotic_resistance ARO:3002424 OKP-A-7 OKP-A-7 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-7 OKP-A-8 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-8 antibiotic_resistance ARO:3002425 OKP-A-8 OKP-A-8 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-8 OKP-A-9 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-9 antibiotic_resistance ARO:3002426 OKP-A-9 OKP-A-9 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-9 OKP-A-10 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-10 antibiotic_resistance ARO:3002427 OKP-A-10 OKP-A-10 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-10 OKP-A-11 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-11 antibiotic_resistance ARO:3002428 OKP-A-11 OKP-A-11 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 OKP-A-11 OKP-A-12 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-12 antibiotic_resistance ARO:3002429 OKP-A-12 OKP-A-12 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 OKP-A-12 OKP-A-13 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-13 antibiotic_resistance ARO:3002430 OKP-A-13 OKP-A-13 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22143810 OKP-A-13 OKP-A-14 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-14 antibiotic_resistance ARO:3002431 OKP-A-14 OKP-A-14 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22143810 OKP-A-14 OKP-A-15 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-15 antibiotic_resistance ARO:3002432 OKP-A-15 OKP-A-15 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22143810 OKP-A-15 OKP-A-16 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-16 antibiotic_resistance ARO:3002433 OKP-A-16 OKP-A-16 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22143810 OKP-A-16 OKP-B-1 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-1 antibiotic_resistance ARO:3002434 OKP-B-1 OKP-B-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-1 OKP-B-2 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-2 antibiotic_resistance ARO:3002435 OKP-B-2 OKP-B-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-2 OKP-B-3 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-3 antibiotic_resistance ARO:3002436 OKP-B-3 OKP-B-3 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-3 OKP-B-4 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-4 antibiotic_resistance ARO:3002437 OKP-B-4 OKP-B-4 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-4 OKP-B-5 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-5 antibiotic_resistance ARO:3002438 OKP-B-5 OKP-B-5 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15980410 OKP-B-5 OKP-B-6 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-15 OKP-B-6 antibiotic_resistance ARO:3002439 OKP-B-6 OKP-B-6 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15980410 OKP-B-6 OKP-B-7 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-7 antibiotic_resistance ARO:3002440 OKP-B-7 OKP-B-7 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-7 OKP-B-8 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-8 antibiotic_resistance ARO:3002441 OKP-B-8 OKP-B-8 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-8 OKP-B-9 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-9 antibiotic_resistance ARO:3002442 OKP-B-9 OKP-B-9 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-9 OKP-B-10 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-10 antibiotic_resistance ARO:3002443 OKP-B-10 OKP-B-10 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-10 OKP-B-11 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-11 antibiotic_resistance ARO:3002444 OKP-B-11 OKP-B-11 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-11 OKP-B-12 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-12 antibiotic_resistance ARO:3002445 OKP-B-12 OKP-B-12 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 OKP-B-12 OKP-B-13 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-13 antibiotic_resistance ARO:3002446 OKP-B-13 OKP-B-13 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16769193 OKP-B-13 OKP-B-14 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-14 antibiotic_resistance ARO:3002447 OKP-B-14 OKP-B-14 is a beta-lactamase found in Klebsiella pneumoniae. PMID:17442542 OKP-B-14 OKP-B-17 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-17 antibiotic_resistance ARO:3002450 OKP-B-17 OKP-B-17 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 OKP-B-17 OKP-B-18 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-18 antibiotic_resistance ARO:3002451 OKP-B-18 OKP-B-18 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 OKP-B-18 OKP-B-19 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-19 antibiotic_resistance ARO:3002452 OKP-B-19 OKP-B-19 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 OKP-B-19 OKP-B-20 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-20 antibiotic_resistance ARO:3002453 OKP-B-20 OKP-B-20 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 OKP-B-20 LEN-1 is a beta-lactamase found in Klebsiella pneumoniae. LEN-1 antibiotic_resistance ARO:3002454 LEN-1 LEN-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:3533626 LEN-1 LEN-2 is a beta-lactamase found in Klebsiella pneumoniae. LEN-2 antibiotic_resistance ARO:3002455 LEN-2 LEN-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-2 LEN-5 is a beta-lactamase found in Klebsiella pneumoniae. LEN-5 antibiotic_resistance ARO:3002456 LEN-5 LEN-5 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-5 LEN-7 is a beta-lactamase found in Klebsiella pneumoniae. LEN-7 antibiotic_resistance ARO:3002457 LEN-7 LEN-7 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-7 LEN-8 is a beta-lactamase found in Klebsiella pneumoniae. LEN-8 antibiotic_resistance ARO:3002458 LEN-8 LEN-8 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-8 LEN-9 is a beta-lactamase found in Klebsiella pneumoniae. LEN-9 antibiotic_resistance ARO:3002459 LEN-9 LEN-9 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-9 LEN-10 is a beta-lactamase found in Klebsiella pneumoniae. LEN-10 antibiotic_resistance ARO:3002460 LEN-10 LEN-10 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-10 LEN-11 is a beta-lactamase found in Klebsiella pneumoniae. LEN-11 antibiotic_resistance ARO:3002461 LEN-11 LEN-11 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-11 LEN-12 is a beta-lactamase found in Klebsiella pneumoniae. LEN-12 antibiotic_resistance ARO:3002462 LEN-12 LEN-12 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-12 LEN-13 is a beta-lactamase found in Klebsiella pneumoniae and Klebsiella variicola. LEN-13 antibiotic_resistance ARO:3002463 LEN-13 LEN-13 is a beta-lactamase found in Klebsiella pneumoniae and Klebsiella variicola. PMID:15215087 PMID:19965433 LEN-13 LEN-16 is a beta-lactamase found in Klebsiella pneumoniae. LEN-16 antibiotic_resistance ARO:3002464 LEN-16 LEN-16 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15980410 LEN-16 LEN-18 is a beta-lactamase found in Klebsiella pneumoniae. LEN-18 antibiotic_resistance ARO:3002465 LEN-18 LEN-18 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-18 LEN-19 is a beta-lactamase found in Klebsiella pneumoniae. LEN-19 antibiotic_resistance ARO:3002466 LEN-19 LEN-19 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-19 LEN-20 is a beta-lactamase found in Klebsiella pneumoniae. LEN-20 antibiotic_resistance ARO:3002467 LEN-20 LEN-20 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-20 LEN-21 is a beta-lactamase found in Klebsiella pneumoniae. LEN-21 antibiotic_resistance ARO:3002468 LEN-21 LEN-21 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-21 LEN-22 is a beta-lactamase found in Klebsiella pneumoniae. LEN-22 antibiotic_resistance ARO:3002469 LEN-22 LEN-22 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-22 LEN-23 is a beta-lactamase found in Klebsiella pneumoniae. LEN-23 antibiotic_resistance ARO:3002470 LEN-23 LEN-23 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-23 LEN-24 is a beta-lactamase found in Klebsiella pneumoniae. LEN-24 antibiotic_resistance ARO:3002471 LEN-24 LEN-24 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-24 LEN-4 is a beta-lactamase found in Escherichia coli. LEN-4 antibiotic_resistance ARO:3002472 LEN-4 LEN-4 is a beta-lactamase found in Escherichia coli. PMID:22809702 LEN-4 LEN-17 is a beta-lactamase found in Escherichia coli. LEN-17 antibiotic_resistance ARO:3002473 LEN-17 LEN-17 is a beta-lactamase found in Escherichia coli. PMID:22809702 LEN-17 LEN-26 is a beta-lactamase found in Escherichia coli and Klebsiella pneumoniae. LEN-26 antibiotic_resistance ARO:3002474 LEN-26 LEN-26 is a beta-lactamase found in Escherichia coli and Klebsiella pneumoniae. PMID:22809702 LEN-26 LEN-3 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases. LEN-3 antibiotic_resistance ARO:3002475 LEN-3 LEN-3 LEN-6 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases. LEN-6 antibiotic_resistance ARO:3002476 LEN-6 LEN-6 LEN-14 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases. LEN-14 antibiotic_resistance ARO:3002477 LEN-14 LEN-14 LEN-15 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases. LEN-15 antibiotic_resistance ARO:3002478 LEN-15 LEN-15 LEN-25 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases. LEN-25 antibiotic_resistance ARO:3002479 LEN-25 LEN-25 OXA-144 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-144 antibiotic_resistance ARO:3002480 OXA-144 OXA-144 AER-1 is a beta-lactamase found in Aeromonas hydrophila. AER-1 antibiotic_resistance ARO:3002481 AER-1 AER-1 is a beta-lactamase found in Aeromonas hydrophila. PMID:3890725 AER-1 LRA-1 is a beta-lactamase isolated from soil samples in Alaska. LRA-1 antibiotic_resistance ARO:3002482 LRA-1 LRA-1 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-1 LRA-5 is a beta-lactamase isolated from soil samples in Alaska. LRA-5 antibiotic_resistance ARO:3002483 LRA-5 LRA-5 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-5 LRA-13 is a class D/class C fusion bifunctional beta-lactamase isolated from soil samples in Alaska. LRA-13 antibiotic_resistance ARO:3002484 LRA-13 LRA-13 is a class D/class C fusion bifunctional beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-13 LRA-2 is a beta-lactamase isolated from soil samples in Alaska. LRA-2 antibiotic_resistance ARO:3002485 LRA-2 LRA-2 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-2 LRA-7 is a beta-lactamase isolated from soil samples in Alaska. LRA-7 antibiotic_resistance ARO:3002486 LRA-7 LRA-7 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-7 LRA-8 is a beta-lactamase isolated from soil samples in Alaska. LRA-8 antibiotic_resistance ARO:3002487 LRA-8 LRA-8 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-8 LRA-9 is a beta-lactamase isolated from soil samples in Alaska. LRA-9 antibiotic_resistance ARO:3002488 LRA-9 LRA-9 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-9 LRA-10 is a beta-lactamase isolated from soil samples in Alaska. LRA-10 antibiotic_resistance ARO:3002489 LRA-10 LRA-10 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-10 LRA-18 is a beta-lactamase isolated from soil samples in Alaska. LRA-18 antibiotic_resistance ARO:3002492 LRA-18 LRA-18 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-18 SRT-1, isolated from Serratia marcescens, confers resistance to cephalosporins but not carbapenems, penems and monobactams. SRT-1 antibiotic_resistance ARO:3002493 SRT-1 SRT-1, isolated from Serratia marcescens, confers resistance to cephalosporins but not carbapenems, penems and monobactams. PMID:8540730 SRT-1 SRT-2, isolated from Serratia marcescens, is a chromosomal beta-lactamase that confers resistance to cefotaxime. SRT-2 antibiotic_resistance ARO:3002494 SRT-2 SRT-2, isolated from Serratia marcescens, is a chromosomal beta-lactamase that confers resistance to cefotaxime. PMID:15183862 SRT-2 CTX-M-85 is a beta-lactamase found in Salmonella enterica. CTX-M-85 antibiotic_resistance ARO:3002495 CTX-M-85 CTX-M-85 is a beta-lactamase found in Salmonella enterica. PMID:18984647 CTX-M-85 OXA-418 is a beta-lactamase. From the Lahey list of OXA beta-lactamases. OXA-418 antibiotic_resistance ARO:3002496 OXA-418 OXA-418 PDC-1 is a beta-lactamase found in Pseudomonas aeruginosa. PDC-1 antibiotic_resistance ARO:3002497 PDC-1 PDC-1 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-1 PDC-2 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-2 antibiotic_resistance ARO:3002498 PDC-2 PDC-2 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-2 PDC-3 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-3 antibiotic_resistance ARO:3002500 PDC-3 PDC-3 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PMID:33416461 PDC-3 PDC-4 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-4 antibiotic_resistance ARO:3002501 PDC-4 PDC-4 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-4 PDC-5 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-5 antibiotic_resistance ARO:3002502 PDC-5 PDC-5 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PMID:33416461 PDC-5 PDC-6 is a beta-lactamase found in Pseudomonas aeruginosa. PDC-6 antibiotic_resistance ARO:3002505 PDC-6 PDC-6 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-6 PDC-7 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-7 antibiotic_resistance ARO:3002506 PDC-7 PDC-7 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-7 PDC-8 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-8 antibiotic_resistance ARO:3002507 PDC-8 PDC-8 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-8 PDC-9 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-9 antibiotic_resistance ARO:3002508 PDC-9 PDC-9 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-9 PDC-10 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-10 antibiotic_resistance ARO:3002509 PDC-10 PDC-10 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-10 LRA-3 is a beta-lactamase isolated from soil samples in Alaska. LRA-3 antibiotic_resistance ARO:3002510 LRA-3 LRA-3 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-3 LRA-12 is a beta-lactamase isolated from soil samples in Alaska. LRA-12 antibiotic_resistance ARO:3002511 LRA-12 LRA-12 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-12 LRA-17 is a beta-lactamase isolated from soil samples in Alaska. LRA-17 antibiotic_resistance ARO:3002512 LRA-17 LRA-17 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-17 LRA-19 is a beta-lactamase isolated from soil samples in Alaska. LRA-19 antibiotic_resistance ARO:3002513 LRA-19 LRA-19 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-19 OCH-1 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. OCH-1 Ochrobactrum anthropi antibiotic_resistance ARO:3002514 OCH-1 OCH-1 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 OCH-1 OCH-2 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi. OCH-2 antibiotic_resistance ARO:3002515 OCH-2 OCH-2 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi. PMID:11451692 OCH-2 OCH-3 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. OCH-3 antibiotic_resistance ARO:3002516 OCH-3 OCH-3 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 OCH-3 OCH-4 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. OCH-4 antibiotic_resistance ARO:3002517 OCH-4 OCH-4 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 OCH-4 OCH-5 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. OCH-5 antibiotic_resistance ARO:3002518 OCH-5 OCH-5 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 OCH-5 OCH-6 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. OCH-6 antibiotic_resistance ARO:3002519 OCH-6 OCH-6 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 OCH-6 OCH-7 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi. OCH-7 antibiotic_resistance ARO:3002520 OCH-7 OCH-7 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi. PMID:11451692 OCH-7 OCH-8 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. OCH-8 antibiotic_resistance ARO:3002521 OCH-8 OCH-8 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 OCH-8 A type III ABC transporter, identified on the novobiocin biosynthetic gene cluster, involved in the transport and resistance of novobiocin. novA antibiotic_resistance ARO:3002522 novA A type III ABC transporter, identified on the novobiocin biosynthetic gene cluster, involved in the transport and resistance of novobiocin. PMID:12604514 novA AAC(2')-Ia is a chromosomal-encoded aminoglycoside acetyltransferase in P. stuartii. AAC(2')-Ia antibiotic_resistance ARO:3002523 AAC(2')-Ia AAC(2')-Ia is a chromosomal-encoded aminoglycoside acetyltransferase in P. stuartii. PMID:8407825 AAC(2')-Ia AAC(2')-Ib is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium fortuitum and A. baumannii. AAC(2')-Ib antibiotic_resistance ARO:3002524 AAC(2')-Ib AAC(2')-Ib is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium fortuitum and A. baumannii. PMID:8891143 AAC(2')-Ib AAC(2')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in M. tuberculosis and Mycobacterium tuberculosis variant bovis. AAC(2')-Ic antibiotic_resistance ARO:3002525 AAC(2')-Ic AAC(2')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in M. tuberculosis and Mycobacterium tuberculosis variant bovis. PMID:9159528 AAC(2')-Ic AAC(2')-Id is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium smegmatis. AAC(2')-Id antibiotic_resistance ARO:3002526 AAC(2')-Id AAC(2')-Id is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium smegmatis. PMID:9159528 AAC(2')-Id AAC(2')-Ie is a chromosomal-encoded aminoglycoside acetyltransferase in M. leprae. AAC(2')-Ie antibiotic_resistance ARO:3002527 AAC(2')-Ie AAC(2')-Ie is a chromosomal-encoded aminoglycoside acetyltransferase in M. leprae. PMID:9159528 AAC(2')-Ie AAC(3)-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in S. marcescens, E. coli, Acinetobacter baumannii, Klebsiella pneumoniae, Klebsiella oxytoca, P. aeruginosa, Salmonella typhimurium and Proteus mirabilis. AAC(3)-Ia AAC(3)-Ia C aacC-A1 aacC1 antibiotic_resistance ARO:3002528 AAC(3)-Ia AAC(3)-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in S. marcescens, E. coli, Acinetobacter baumannii, Klebsiella pneumoniae, Klebsiella oxytoca, P. aeruginosa, Salmonella typhimurium and Proteus mirabilis. PMID:1960117 PMID:2549372 AAC(3)-Ia AAC(3)-Id is an aminoglycoside acetyltransferase encoded by genomic islands and integrons in S. enterica, P. mirabilis and Vibrio fluvialis. AAC(3)-Id AAC(3)-Ie aacCA5 antibiotic_resistance ARO:3002529 AAC(3)-Id AAC(3)-Id is an aminoglycoside acetyltransferase encoded by genomic islands and integrons in S. enterica, P. mirabilis and Vibrio fluvialis. PMID:15388438 PMID:15728939 PMID:18476779 AAC(3)-Id AAC(3)-Ib is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(3)-Ib aacCA2 antibiotic_resistance ARO:3002530 AAC(3)-Ib AAC(3)-Ib is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:7486920 AAC(3)-Ib AAC(3)-Ic is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(3)-Ic aacCA3 antibiotic_resistance ARO:3002531 AAC(3)-Ic AAC(3)-Ic is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:12709352 AAC(3)-Ic AAC(3)-IIa is a plasmid-encoded aminoglycoside acetyltransferase in K. pneumoniae, E. cloacae, Actinobacillus pleuropneumoniae, S. typhimurium, Citrobacter freundii, and P. aeruginosa. AAC(3)-IIa aaC3 aac(3)-Va aacC2 aacC5 antibiotic_resistance ARO:3002533 AAC(3)-IIa AAC(3)-IIa is a plasmid-encoded aminoglycoside acetyltransferase in K. pneumoniae, E. cloacae, Actinobacillus pleuropneumoniae, S. typhimurium, Citrobacter freundii, and P. aeruginosa. PMID:3892230 PMID:8385262 PMID:8913451 AAC(3)-IIa AAC(3)-IIb is an aminoglycoside acetyltransferase in E. coli, A. faecalis and S. marcescens. AAC(3)-IIb aac(3)-Vb antibiotic_resistance ARO:3002534 AAC(3)-IIb AAC(3)-IIb is an aminoglycoside acetyltransferase in E. coli, A. faecalis and S. marcescens. PMID:1444303 PMID:8385262 AAC(3)-IIb AAC(3)-IIc is a plasmid-encoded aminoglycoside acetyltransferase in E. coli and P. aeruginosa. AAC(3)-IIc aacC2 antibiotic_resistance ARO:3002535 AAC(3)-IIc AAC(3)-IIc is a plasmid-encoded aminoglycoside acetyltransferase in E. coli and P. aeruginosa. PMID:18467306 PMID:8385262 AAC(3)-IIc AAC(3)-IIIa is a chromosomal-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(3)-IIIa aacC3 antibiotic_resistance ARO:3002536 AAC(3)-IIIa AAC(3)-IIIa is a chromosomal-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:1649572 AAC(3)-IIIa AAC(3)-IIIb is an aminoglycoside acetyltransferase in P. aeruginosa. AAC(3)-IIIb antibiotic_resistance ARO:3002537 AAC(3)-IIIb AAC(3)-IIIb is an aminoglycoside acetyltransferase in P. aeruginosa. PMID:20387903 AAC(3)-IIIb AAC(3)-IIIc is an aminoglycoside acetyltransferase in P. aeruginosa. AAC(3)-IIIc ANT(2'')-Ib antibiotic_resistance ARO:3002538 AAC(3)-IIIc AAC(3)-IIIc is an aminoglycoside acetyltransferase in P. aeruginosa. PMID:8385262 AAC(3)-IIIc AAC(3)-IV is a plasmid-encoded aminoglycoside acetyltransferase in E. coli, C. jejuni and P. stutzeri. AAC(3)-IVa aacC4 antibiotic_resistance ARO:3002539 AAC(3)-IVa AAC(3)-IV is a plasmid-encoded aminoglycoside acetyltransferase in E. coli, C. jejuni and P. stutzeri. PMID:19709289 PMID:6318050 AAC(3)-IVa AAC(3)-VIa is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae, S. enterica and E. coli. AAC(3)-VIa antibiotic_resistance ARO:3002540 AAC(3)-VIa AAC(3)-VIa is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae, S. enterica and E. coli. PMID:19949054 PMID:8257126 AAC(3)-VIa AAC(3)-VIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces rimosus. AAC(3)-VIIa aacC7 antibiotic_resistance ARO:3002541 AAC(3)-VIIa AAC(3)-VIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces rimosus. PMID:2914849 AAC(3)-VIIa AAC(3)-VIIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces fradiae. AAC(3)-VIIIa aacC8 antibiotic_resistance ARO:3002542 AAC(3)-VIIIa AAC(3)-VIIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces fradiae. PMID:2060791 AAC(3)-VIIIa AAC(3)-IXa is a chromosomal-encoded aminoglycoside acetyltransferase in Micromonospora chalcea. AAC(3)-IXa aacC9 antibiotic_resistance ARO:3002543 AAC(3)-IXa AAC(3)-IXa is a chromosomal-encoded aminoglycoside acetyltransferase in Micromonospora chalcea. PMID:2060791 AAC(3)-IXa AAC(3)-Xa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces griseus. AAC(3)-Xa antibiotic_resistance ARO:3002544 AAC(3)-Xa AAC(3)-Xa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces griseus. PMID:10639379 AAC(3)-Xa AAC(6')-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Citrobacter diversus, E. coli, K. pneumoniae, Shigella sonnei, and P. aeruginosa. AAC(6')-Ia aacA1 antibiotic_resistance ARO:3002545 AAC(6')-Ia AAC(6')-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Citrobacter diversus, E. coli, K. pneumoniae, Shigella sonnei, and P. aeruginosa. PMID:1314803 PMID:2826403 AAC(6')-Ia AAC(6')-Ib is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in K. pneumoniae, P. mirabilis, P. aeruginosa, S. enterica, K. oxytoca, S. maltophilia, E. cloacae and V. cholerae. AAC(6')-4 AAC(6')-Ib aacA4 antibiotic_resistance ARO:3002546 AAC(6')-Ib AAC(6')-Ib is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in K. pneumoniae, P. mirabilis, P. aeruginosa, S. enterica, K. oxytoca, S. maltophilia, E. cloacae and V. cholerae. PMID:16641475 PMID:2824444 PMID:2841303 AAC(6')-Ib AAC(6')-Ib-cr is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Enterobacteriaceae. The aac(6')-Ib-cr variant gene can induce resistance against aminoglycoside and fluoroquinolone simultaneously. PDB:1V0C AAC(6')-Ib-cr1 antibiotic_resistance ARO:3002547 AAC(6')-Ib-cr1 AAC(6')-Ib-cr is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Enterobacteriaceae. The aac(6')-Ib-cr variant gene can induce resistance against aminoglycoside and fluoroquinolone simultaneously. PMID:16369542 PMID:18710261 PMID:18812424 AAC(6')-Ib-cr1 AAC(6')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in S. marcescens. AAC(6')-III AAC(6')-Ic antibiotic_resistance ARO:3002549 AAC(6')-Ic AAC(6')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in S. marcescens. PMID:1354954 AAC(6')-Ic AAC(6')-If is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae. AAC(6')-If antibiotic_resistance ARO:3002553 AAC(6')-If AAC(6')-If is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae. PMID:7695286 AAC(6')-If AAC(6')-Ig is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter haemolyticus. AAC(6')-Ig antibiotic_resistance ARO:3002554 AAC(6')-Ig AAC(6')-Ig is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter haemolyticus. PMID:7810994 PMID:8257129 AAC(6')-Ig AAC(6')-Ih is a plasmid-encoded aminoglycoside acetyltransferase in A. baumannii. AAC(6')-Ih antibiotic_resistance ARO:3002555 AAC(6')-Ih AAC(6')-Ih is a plasmid-encoded aminoglycoside acetyltransferase in A. baumannii. PMID:7810994 AAC(6')-Ih AAC(6')-Ii is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus spp. AAC(6')-Ii antibiotic_resistance ARO:3002556 AAC(6')-Ii AAC(6')-Ii is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus spp. PMID:10378269 PMID:12767240 PMID:8239603 AAC(6')-Ii AAC(6')-Ij is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 13. AAC(6')-Ij antibiotic_resistance ARO:3002557 AAC(6')-Ij AAC(6')-Ij is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 13. PMID:7810994 AAC(6')-Ij AAC(6')-Ik is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. AAC(6')-Ik antibiotic_resistance ARO:3002558 AAC(6')-Ik AAC(6')-Ik is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. PMID:8001769 AAC(6')-Ik AAC(6')-Ip is an aminoglycoside acetyltransferase encoded by plasmids and integrons in C. freundii, E. coli, E. faecium and Klebsiella aerogenes. AAC(6')-Ip aacA16 antibiotic_resistance ARO:3002559 AAC(6')-Ip AAC(6')-Ip is an aminoglycoside acetyltransferase encoded by plasmids and integrons in C. freundii, E. coli, E. faecium and Klebsiella aerogenes. PMID:11557456 PMID:7793874 PMID:9021185 AAC(6')-Ip AAC(6')-Iq is a aminoglycoside acetyltransferase encoded by plasmids and integrons in K. pneumoniae. AAC(6')-Iq antibiotic_resistance ARO:3002560 AAC(6')-Iq AAC(6')-Iq is a aminoglycoside acetyltransferase encoded by plasmids and integrons in K. pneumoniae. PMID:9624504 AAC(6')-Iq AAC(6')-Ir is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter colistiniresistens. AAC(6')-Ir antibiotic_resistance ARO:3002561 AAC(6')-Ir AAC(6')-Ir is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter colistiniresistens. PMID:10188279 AAC(6')-Ir AAC(6')-Is is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter variabilis. AAC(6')-Is antibiotic_resistance ARO:3002562 AAC(6')-Is AAC(6')-Is is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter variabilis. PMID:10188279 AAC(6')-Is AAC(6')-Isa is a plasmid-encoded aminoglycoside acetyltransferase in Streptomyces albulus. AAC(6')-Isa antibiotic_resistance ARO:3002563 AAC(6')-Isa AAC(6')-Isa is a plasmid-encoded aminoglycoside acetyltransferase in Streptomyces albulus. PMID:15625322 AAC(6')-Isa AAC(6')-It is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 16. AAC(6')-It antibiotic_resistance ARO:3002564 AAC(6')-It AAC(6')-It is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 16. PMID:10188279 AAC(6')-It AAC(6')-Iu is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 17. AAC(6')-Iu antibiotic_resistance ARO:3002565 AAC(6')-Iu AAC(6')-Iu is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 17. PMID:10188279 AAC(6')-Iu AAC(6')-Iv is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. AAC(6')-Iv antibiotic_resistance ARO:3002566 AAC(6')-Iv AAC(6')-Iv is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. PMID:10188279 AAC(6')-Iv AAC(6')-Iw is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. AAC(6')-Iw antibiotic_resistance ARO:3002567 AAC(6')-Iw AAC(6')-Iw is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. PMID:10188279 AAC(6')-Iw AAC(6')-Ix is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. AAC(6')-Ix antibiotic_resistance ARO:3002568 AAC(6')-Ix AAC(6')-Ix is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. PMID:10188279 AAC(6')-Ix AAC(6')-Iy is a chromosomal-encoded aminoglycoside acetyltransferase in S. enteritidis and S. enterica. Regulatory mutation required to increase expression of this chromosomally-encoded gene for resistance. In the specific system, aminoglycoside resistance was due to a transcriptional fusion secondary to a chromosomal deletion in which the downstream aac(6')-Iy gene was placed under the control of the upstream nmpC promoter. AAC(6')-Iy antibiotic_resistance ARO:3002569 AAC(6')-Iy AAC(6')-Iy is a chromosomal-encoded aminoglycoside acetyltransferase in S. enteritidis and S. enterica. Regulatory mutation required to increase expression of this chromosomally-encoded gene for resistance. In the specific system, aminoglycoside resistance was due to a transcriptional fusion secondary to a chromosomal deletion in which the downstream aac(6')-Iy gene was placed under the control of the upstream nmpC promoter. PMID:10542165 AAC(6')-Iy AAC(6')-Iz is a chromosomal-encoded aminoglycoside acetyltransferase in S. maltophilia. AAC(6')-Iz antibiotic_resistance ARO:3002570 AAC(6')-Iz AAC(6')-Iz is a chromosomal-encoded aminoglycoside acetyltransferase in S. maltophilia. PMID:10508008 AAC(6')-Iz AAC(6')-Iaa is a chromosomal-encoded aminoglycoside acetyltransferase in S. typhimurium. AAC(6')-Iaa antibiotic_resistance ARO:3002571 AAC(6')-Iaa AAC(6')-Iaa is a chromosomal-encoded aminoglycoside acetyltransferase in S. typhimurium. PMID:12679553 AAC(6')-Iaa AAC(6')-Iad is a plasmid-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 3. AAC(6')-Iad antibiotic_resistance ARO:3002572 AAC(6')-Iad AAC(6')-Iad is a plasmid-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 3. PMID:15155202 AAC(6')-Iad AAC(6')-Iae is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa and S. enterica. AAC(6')-Iae antibiotic_resistance ARO:3002573 AAC(6')-Iae AAC(6')-Iae is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa and S. enterica. PMID:16127047 AAC(6')-Iae AAC(6')-Iaf is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. AAC(6')-Iaf antibiotic_resistance ARO:3002574 AAC(6')-Iaf AAC(6')-Iaf is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. PMID:19349516 AAC(6')-Iaf AAC(6')-Iai is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. AAC(6')-Iai antibiotic_resistance ARO:3002575 AAC(6')-Iai AAC(6')-Iai is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. PMID:26270859 AAC(6')-Iai AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(6')-Ib3 AAC(6')-Ib5 aacA4 antibiotic_resistance ARO:3002576 AAC(6')-Ib3 AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:1331747 PMID:9527761 AAC(6')-Ib3 AAC(6')-Ib4 is an aminoglycoside acetyltransferase in Serratia spp. AAC(6')-Ib4 antibiotic_resistance ARO:3002577 AAC(6')-Ib4 AAC(6')-Ib4 is an aminoglycoside acetyltransferase in Serratia spp. PMID:1339319 AAC(6')-Ib4 AAC(6')-Ib7 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae and C. freundii. AAC(6')-Ib7 antibiotic_resistance ARO:3002578 AAC(6')-Ib7 AAC(6')-Ib7 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae and C. freundii. PMID:9527761 AAC(6')-Ib7 AAC(6')-Ib8 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae. AAC(6')-Ib8 antibiotic_resistance ARO:3002579 AAC(6')-Ib8 AAC(6')-Ib8 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae. PMID:9527761 AAC(6')-Ib8 AAC(6')-Ib9 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(6')-Ib9 antibiotic_resistance ARO:3002580 AAC(6')-Ib9 AAC(6')-Ib9 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:9835500 AAC(6')-Ib9 AAC(6')-Ib10 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(6')-Ib10 antibiotic_resistance ARO:3002581 AAC(6')-Ib10 AAC(6')-Ib10 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:9579076 AAC(6')-Ib10 AAC(6')-Ib11 is an integron-encoded aminoglycoside acetyltransferase in S. enterica. AAC(6')-Ib11 antibiotic_resistance ARO:3002582 AAC(6')-Ib11 AAC(6')-Ib11 is an integron-encoded aminoglycoside acetyltransferase in S. enterica. PMID:12543680 AAC(6')-Ib11 AAC(6')-29a is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(6')-29a antibiotic_resistance ARO:3002583 AAC(6')-29a AAC(6')-29a is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:11158753 AAC(6')-29a AAC(6')-29b is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(6')-29b antibiotic_resistance ARO:3002584 AAC(6')-29b AAC(6')-29b is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:11158753 AAC(6')-29b AAC(6')-31 is an integron-encoded aminoglycoside acetyltransferase in Pseudomonas putida, A. baumannii and K. pneumoniae. AAC(6')-31 antibiotic_resistance ARO:3002585 AAC(6')-31 AAC(6')-31 is an integron-encoded aminoglycoside acetyltransferase in Pseudomonas putida, A. baumannii and K. pneumoniae. PMID:17470660 AAC(6')-31 AAC(6')-32 is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. AAC(6')-32 antibiotic_resistance ARO:3002586 AAC(6')-32 AAC(6')-32 is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. PMID:17938181 AAC(6')-32 AAC(6')-I33 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(6')-I33 antibiotic_resistance ARO:3002587 AAC(6')-I33 AAC(6')-I33 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:19738007 AAC(6')-I33 AAC(6')-I30 is an integron-encoded aminoglycoside acetyltransferase in S. enterica. AAC(6')-I30 antibiotic_resistance ARO:3002588 AAC(6')-I30 AAC(6')-I30 is an integron-encoded aminoglycoside acetyltransferase in S. enterica. PMID:15231768 AAC(6')-I30 AAC(6')-Iid is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus durans. AAC(6')-Iid antibiotic_resistance ARO:3002589 AAC(6')-Iid AAC(6')-Iid is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus durans. PMID:15849260 AAC(6')-Iid AAC(6')-Iih is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus hirae. AAC(6')-Iih antibiotic_resistance ARO:3002590 AAC(6')-Iih AAC(6')-Iih is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus hirae. PMID:15849260 AAC(6')-Iih AAC(6')-Ib-Suzhou is an aminoglycoside acetyltransferase in E. cloacae and K. pneumoniae. AAC_6_IB_Su antibiotic_resistance ARO:3002591 AAC(6')-Ib-Suzhou AAC(6')-Ib-Suzhou is an aminoglycoside acetyltransferase in E. cloacae and K. pneumoniae. PMID:18843996 AAC_6_IB_Su AAC(6')-Ib-Hangzhou is an aminoglycoside acetyltransferase in A. baumannii. AAC6_IB_HZ antibiotic_resistance ARO:3002592 AAC(6')-Ib-Hangzhou AAC(6')-Ib-Hangzhou is an aminoglycoside acetyltransferase in A. baumannii. PMID:20833577 AAC6_IB_HZ AAC(6')-Ib-SK is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces kanamyceticus. AAC(6')-Ib-SK AAC(6')-SK kac antibiotic_resistance ARO:3002593 AAC(6')-Ib-SK AAC(6')-Ib-SK is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces kanamyceticus. PMID:3838980 AAC(6')-Ib-SK AAC(6')-IIa is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa and S. enterica. AAC(6')-IIa antibiotic_resistance ARO:3002594 AAC(6')-IIa AAC(6')-IIa is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa and S. enterica. PMID:2515793 AAC(6')-IIa AAC(6')-IIb is an integron-encoded aminoglycoside acetyltransferase in P. fluorescens. AAC(6')-IIb antibiotic_resistance ARO:3002595 AAC(6')-IIb AAC(6')-IIb is an integron-encoded aminoglycoside acetyltransferase in P. fluorescens. PMID:8385262 AAC(6')-IIb AAC(6')-IIc is an aminoglycoside acetyltransferase encoded by plasmids and integrons in E. cloacae. AAC(6')-IIc antibiotic_resistance ARO:3002596 AAC(6')-IIc AAC(6')-IIc is an aminoglycoside acetyltransferase encoded by plasmids and integrons in E. cloacae. PMID:15761066 AAC(6')-IIc AAC(6')-Ie-APH(2'')-Ia is an aminoglycoside acetyltransferase encoded by plasmids and transposons in S. aureus, E. faecalis, E. faecium and Staphylococcus warneri. AAC6_Ie_APH2_Ia APH(2''), aph(2'')-bifunctional, AAC(6')-APH(2'') aac(6')-bifunctional aacA-aphD antibiotic_resistance ARO:3002597 AAC(6')-Ie-APH(2'')-Ia bifunctional protein AAC(6')-Ie-APH(2'')-Ia is an aminoglycoside acetyltransferase encoded by plasmids and transposons in S. aureus, E. faecalis, E. faecium and Staphylococcus warneri. PMID:10021417 PMID:2833561 AAC6_Ie_APH2_Ia ANT(3'')-II-AAC(6')-IId is an integron-encoded aminoglycoside acetyltransferase in S. marcescens. ANT3II_ANT6II antibiotic_resistance ARO:3002598 ANT(3'')-II-AAC(6')-IId bifunctional protein ANT(3'')-II-AAC(6')-IId is an integron-encoded aminoglycoside acetyltransferase in S. marcescens. PMID:11959575 ANT3II_ANT6II AAC(6')-30/AAC(6')-Ib' is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC6_30_AAC6_Ib antibiotic_resistance ARO:3002599 AAC(6')-30/AAC(6')-Ib' bifunctional protein AAC(6')-30/AAC(6')-Ib' is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:15561846 AAC6_30_AAC6_Ib AAC(3)-Ib/AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC_3Ib_AAC_6Ib antibiotic_resistance ARO:3002600 AAC(3)-Ib/AAC(6')-Ib3 bifunctional protein AAC(3)-Ib/AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:11850242 AAC_3Ib_AAC_6Ib ANT(3'')-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons, integrons in Enterobacteriaceae, A. baumannii, P. aeruginosa and Vibrio cholerae. aadA aadA, aadA1, aad(3'')(9) aadA1-pm antibiotic_resistance ARO:3002601 aadA ANT(3'')-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons, integrons in Enterobacteriaceae, A. baumannii, P. aeruginosa and Vibrio cholerae. PMID:2986186 aadA aadA2 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in K. pneumoniae, Salmonella spp., Corynebacterium glutamicum, C. freundii and Aeromonas spp. aadA2 antibiotic_resistance ARO:3002602 aadA2 aadA2 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in K. pneumoniae, Salmonella spp., Corynebacterium glutamicum, C. freundii and Aeromonas spp. PMID:17526756 aadA2 aadA3 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli. aadA3 antibiotic_resistance ARO:3002603 aadA3 aadA3 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli. PMID:1314803 aadA3 aadA4 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Bordetella parapertussis and E. coli. aadA4 antibiotic_resistance ARO:3002604 aadA4 aadA4 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Bordetella parapertussis and E. coli. PMID:12910271 PMID:18458128 aadA4 aadA5 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli, K. pneumoniae, Kluyvera georgiana, P. aeruginosa and E. cloacae. aadA5 antibiotic_resistance ARO:3002605 aadA5 aadA5 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli, K. pneumoniae, Kluyvera georgiana, P. aeruginosa and E. cloacae. PMID:10582907 aadA5 aadA6 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa. aadA6 antibiotic_resistance ARO:3002606 aadA6 aadA6 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa. PMID:10673049 aadA6 aadA7 is an integron-encoded aminoglycoside nucleotidyltransferase gene in V. fluvialis, P. aeruginosa, E. coli, V. cholerae and S. enterica. aadA7 antibiotic_resistance ARO:3002607 aadA7 aadA7 is an integron-encoded aminoglycoside nucleotidyltransferase gene in V. fluvialis, P. aeruginosa, E. coli, V. cholerae and S. enterica. PMID:15117923 aadA7 aadA8 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in V. cholerae, K. pneumoniae and Bacillus endophyticus. aadA8 antibiotic_resistance ARO:3002608 aadA8 aadA8 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in V. cholerae, K. pneumoniae and Bacillus endophyticus. PMID:19719593 aadA8 aadA9 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in C. glutamicum. aadA9 antibiotic_resistance ARO:3002609 aadA9 aadA9 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in C. glutamicum. PMID:12383729 aadA9 aadA11 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli and P. aeruginosa. aadA11 antibiotic_resistance ARO:3002611 aadA11 aadA11 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli and P. aeruginosa. PMID:16451415 aadA11 aadA12 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli, Yersinia enterocolitica and S. enterica. aadA12 antibiotic_resistance ARO:3002612 aadA12 aadA12 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli, Yersinia enterocolitica and S. enterica. PMID:19538087 aadA12 aadA13 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in Pseudomonas rettgeri, P. aeruginosa, Y. enterocolitica and E. coli. aadA13 antibiotic_resistance ARO:3002613 aadA13 aadA13 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in Pseudomonas rettgeri, P. aeruginosa, Y. enterocolitica and E. coli. PMID:18268088 aadA13 aadA14 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in Pasteurella multocida. aadA14 antibiotic_resistance ARO:3002614 aadA14 aadA14 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in Pasteurella multocida. PMID:15980396 aadA14 aadA15 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa. aadA15 antibiotic_resistance ARO:3002615 aadA15 aadA15 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa. PMID:16816399 aadA15 aadA16 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in E. coli, V. cholerae and K. pneumoniae. aadA16 antibiotic_resistance ARO:3002616 aadA16 aadA16 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in E. coli, V. cholerae and K. pneumoniae. PMID:19008256 aadA16 aadA17 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Aeromonas media. aadA17 antibiotic_resistance ARO:3002617 aadA17 aadA17 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Aeromonas media. PMID:22127350 aadA17 aadA21 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Salmonella spp. aadA21 antibiotic_resistance ARO:3002618 aadA21 aadA21 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Salmonella spp. PMID:12760885 aadA21 aadA22 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in S. enterica and E. coli. aadA22 antibiotic_resistance ARO:3002619 aadA22 aadA22 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in S. enterica and E. coli. PMID:17597002 aadA22 aadA23 is an integron-encoded aminoglycoside nucleotidyltransferase gene in S. enterica. aadA23 antibiotic_resistance ARO:3002620 aadA23 aadA23 is an integron-encoded aminoglycoside nucleotidyltransferase gene in S. enterica. PMID:15761062 aadA23 aadA24 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Salmonella spp. aadA24 antibiotic_resistance ARO:3002621 aadA24 aadA24 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Salmonella spp. PMID:17650961 aadA24 aadA6/aadA10 is an integron-encoded aminoglycoside nucleotidyltransferase gene cassette in P. aeruginosa. aadA6/aadA10 antibiotic_resistance ARO:3002622 aadA6/aadA10 aadA6/aadA10 is an integron-encoded aminoglycoside nucleotidyltransferase gene cassette in P. aeruginosa. PMID:16495246 aadA6/aadA10 ANT(4')-Ia is a plasmid-encoded aminoglycoside nucleotidyltransferase in S. epidermidis, S. aureus, Enterococcus spp. and Bacillus spp. ANT(4')-Ia aadD1 antibiotic_resistance ARO:3002623 ANT(4')-Ia ANT(4')-Ia is a plasmid-encoded aminoglycoside nucleotidyltransferase in S. epidermidis, S. aureus, Enterococcus spp. and Bacillus spp. PMID:3010356 PMID:659332 ANT(4')-Ia ANT(4')-IIa is a plasmid-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa and Enterobacteriaceae. ANT(4')-IIa antibiotic_resistance ARO:3002624 ANT(4')-IIa ANT(4')-IIa is a plasmid-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa and Enterobacteriaceae. PMID:1965106 PMID:8494365 ANT(4')-IIa ANT(4')-IIb is a transposon-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa. ANT(4')-IIb antibiotic_resistance ARO:3002625 ANT(4')-IIb ANT(4')-IIb is a transposon-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa. PMID:12709326 ANT(4')-IIb ANT(6)-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Staphylococcus epidermidis, E. faecium, Streptococcus suis, S. aureus, E. faecalis and Streptococcus mitis. ANT(6)-Ia ant6, aadE antibiotic_resistance ARO:3002626 ANT(6)-Ia ANT(6)-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Staphylococcus epidermidis, E. faecium, Streptococcus suis, S. aureus, E. faecalis and Streptococcus mitis. PMID:15774886 PMID:19603075 PMID:2168151 ANT(6)-Ia aadK is a chromosomal-encoded aminoglycoside nucleotidyltransferase gene in B. subtilis and Bacillus spp. This enzyme confers low-level resistance to streptomycin. aadK antibiotic_resistance ARO:3002627 aadK aadK is a chromosomal-encoded aminoglycoside nucleotidyltransferase gene in B. subtilis and Bacillus spp. This enzyme confers low-level resistance to streptomycin. PMID:2550327 PMID:8293959 aadK ANT(6)-Ia/aad(6) is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in E. faecalis and Streptococcus oralis. aac(6) aad(6) antibiotic_resistance ARO:3002628 aad(6) ANT(6)-Ia/aad(6) is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in E. faecalis and Streptococcus oralis. PMID:11735367 PMID:17407061 aad(6) ANT(6)-Ib is an aminoglycoside nucleotidyltransferase gene encoded by transferable pathogenicity islands in C. fetus subsp. fetus and B. subtilis. ANT(6)-Ib antibiotic_resistance ARO:3002629 ANT(6)-Ib ANT(6)-Ib is an aminoglycoside nucleotidyltransferase gene encoded by transferable pathogenicity islands in C. fetus subsp. fetus and B. subtilis. PMID:20479200 ANT(6)-Ib ANT(9)-Ia is an aminoglycoside nucleotidyltransferase encoded by plasmids and transposons in S. aureus, Enterococcus spp., Mammaliicoccus sciuri, and E. faecalis. ANT(9)-Ia aad(9) aad9 spc spw antibiotic_resistance ARO:3002630 ANT(9)-Ia ANT(9)-Ia is an aminoglycoside nucleotidyltransferase encoded by plasmids and transposons in S. aureus, Enterococcus spp., Mammaliicoccus sciuri, and E. faecalis. PMID:23511231 PMID:2993813 PMID:3004956 ANT(9)-Ia spd is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in S. aureus. spd antibiotic_resistance ARO:3002631 spd spd is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in S. aureus. PMID:24402501 spd APH(2'')-Ie is a plasmid or transposon-encoded aminoglycoside phosphotransferase in E. faecium and E. casseliflavus. APH(2'')-Ie antibiotic_resistance ARO:3002634 APH(2'')-Ie APH(2'')-Ie is a plasmid or transposon-encoded aminoglycoside phosphotransferase in E. faecium and E. casseliflavus. PMID:17030911 APH(2'')-Ie APH(2'')-IIa is a chromosomal-encoded aminoglycoside phosphotransferase in E. faecium and E. coli. PDB:3HAV APH(2'')-IIa aph(2'')-Ib antibiotic_resistance ARO:3002635 APH(2'')-IIa APH(2'')-IIa is a chromosomal-encoded aminoglycoside phosphotransferase in E. faecium and E. coli. PMID:10991878 APH(2'')-IIa APH(2'')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in Enterococcus gallinarum. APH(2'')-IIIa aph(2'')-Ic antibiotic_resistance ARO:3002636 APH(2'')-IIIa APH(2'')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in Enterococcus gallinarum. PMID:9055984 APH(2'')-IIIa APH(2'')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in E. casseliflavus. PDB:3N4T APH(2'')-IVa aph(2'')-Id antibiotic_resistance ARO:3002637 APH(2'')-IVa APH(2'')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in E. casseliflavus. PMID:9593155 APH(2'')-IVa APH(3'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus. APH(3'')-Ia aphD2 aphE antibiotic_resistance ARO:3002638 APH(3'')-Ia APH(3'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus. PMID:2167474 APH(3'')-Ia APH(3'')-Ib is an aminoglycoside phosphotransferase encoded by plasmids, transposons, integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. APH(3'')-Ib orfH strA antibiotic_resistance ARO:3002639 APH(3'')-Ib APH(3'')-Ib is an aminoglycoside phosphotransferase encoded by plasmids, transposons, integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. PMID:2653965 APH(3'')-Ib APH(3'')-Ic is a chromosomal-encoded aminoglycoside phosphotransferase in Mycolicibacterium fortuitum. APH(3'')-Ic antibiotic_resistance ARO:3002640 APH(3'')-Ic APH(3'')-Ic is a chromosomal-encoded aminoglycoside phosphotransferase in Mycolicibacterium fortuitum. PMID:16954315 APH(3'')-Ic APH(3')-Ia is a transposon-encoded aminoglycoside phosphotransferase in E. coli and S. enterica. It is identical at the protein sequence to APH(3')-Ic, an aminoglycoside phosphotransferase encoded by plasmids, transposons and genomic islands in K. pneumoniae, A. baumannii, S. marcescens, Corynebacterium spp., Photobacterium spp. and Citrobacter spp. APH(3')-Ia APH(3')-Ic aphA-1 apha1-1AB apha7 antibiotic_resistance ARO:3002641 APH(3')-Ia APH(3')-Ia is a transposon-encoded aminoglycoside phosphotransferase in E. coli and S. enterica. It is identical at the protein sequence to APH(3')-Ic, an aminoglycoside phosphotransferase encoded by plasmids, transposons and genomic islands in K. pneumoniae, A. baumannii, S. marcescens, Corynebacterium spp., Photobacterium spp. and Citrobacter spp. PMID:10732668 PMID:2160941 PMID:6270337 APH(3')-Ia APH(3')-Ib is a plasmid-encoded aminoglycoside phosphotransferase in E. coli. APH(3')-Ib aphA-like antibiotic_resistance ARO:3002642 APH(3')-Ib APH(3')-Ib is a plasmid-encoded aminoglycoside phosphotransferase in E. coli. PMID:2832861 APH(3')-Ib APH(3')-IIa is a transposon-encoded aminoglycoside phosphotransferase in E. coli. PDB:1ND4 APH(3')-IIa aphA-2 antibiotic_resistance ARO:3002644 APH(3')-IIa APH(3')-IIa is a transposon-encoded aminoglycoside phosphotransferase in E. coli. PMID:6295884 APH(3')-IIa APH(3')-IIb is a chromosomal-encoded aminoglycoside phosphotransferase in P. aeruginosa. APH(3')-IIb APH(3')-IIps antibiotic_resistance ARO:3002645 APH(3')-IIb APH(3')-IIb is a chromosomal-encoded aminoglycoside phosphotransferase in P. aeruginosa. PMID:10984043 PMID:14638496 APH(3')-IIb APH(3')-IIc is a chromosomal-encoded aminoglycoside phosphotransferase in S. maltophilia. APH(3')-IIc antibiotic_resistance ARO:3002646 APH(3')-IIc APH(3')-IIc is a chromosomal-encoded aminoglycoside phosphotransferase in S. maltophilia. PMID:17088477 APH(3')-IIc APH(3')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in S. aureus and Enterococcus spp. PDB:1L8T APH(3')-IIIa antibiotic_resistance ARO:3002647 APH(3')-IIIa APH(3')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in S. aureus and Enterococcus spp. PMID:6313476 APH(3')-IIIa APH(3')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in Niallia circulans. APH(3')-IVa aphA-4 antibiotic_resistance ARO:3002648 APH(3')-IVa APH(3')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in Niallia circulans. PMID:3006668 APH(3')-IVa APH(3')-Va is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces fradiae. APH(3')-Va aphA-5a antibiotic_resistance ARO:3002649 APH(3')-Va APH(3')-Va is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces fradiae. PMID:6310563 APH(3')-Va APH(3')-Vb is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces ribosidificus. APH(3')-Vb aphA-5b, rph antibiotic_resistance ARO:3002650 APH(3')-Vb APH(3')-Vb is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces ribosidificus. PMID:2851496 APH(3')-Vb APH(3')-Vc is a chromosomal-encoded aminoglycoside phosphotransferase in M. chalcea. APH(3')-Vc aphA-5c antibiotic_resistance ARO:3002651 APH(3')-Vc APH(3')-Vc is a chromosomal-encoded aminoglycoside phosphotransferase in M. chalcea. PMID:1663923 APH(3')-Vc APH(3')-VIa is a plasmid-encoded aminoglycoside phosphotransferase in A. baumannii. APH(3')-VIa aphA-6 antibiotic_resistance ARO:3002652 APH(3')-VIa APH(3')-VIa is a plasmid-encoded aminoglycoside phosphotransferase in A. baumannii. PMID:2846986 APH(3')-VIa APH(3')-VIb is a plasmid-encoded aminoglycoside phosphotransferase in K. pneumoniae and S. marcescens. APH(3')-VIb antibiotic_resistance ARO:3002653 APH(3')-VIb APH(3')-VIb is a plasmid-encoded aminoglycoside phosphotransferase in K. pneumoniae and S. marcescens. PMID:2848443 APH(3')-VIb APH(3')-VIIa is a plasmid-encoded aminoglycoside phosphotransferase in C. jejuni. APH(3')-VIIa aphA-7 antibiotic_resistance ARO:3002654 APH(3')-VIIa APH(3')-VIIa is a plasmid-encoded aminoglycoside phosphotransferase in C. jejuni. PMID:2550983 APH(3')-VIIa APH(4)-Ia is a plasmid-encoded aminoglycoside phosphotransferase in E. coli. PDB:3OVC APH(4)-Ia hph antibiotic_resistance ARO:3002655 APH(4)-Ia APH(4)-Ia is a plasmid-encoded aminoglycoside phosphotransferase in E. coli. PMID:6314265 APH(4)-Ia APH(4)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in Pseudomonas pseudomallei. APH(4)-Ib hyg antibiotic_resistance ARO:3002656 APH(4)-Ib APH(4)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in Pseudomonas pseudomallei. PMID:3005976 APH(4)-Ib APH(6)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus. APH(6)-Ia aphD antibiotic_resistance ARO:3002657 APH(6)-Ia APH(6)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus. PMID:3118332 APH(6)-Ia APH(6)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. glaucescens. APH(6)-Ib sph antibiotic_resistance ARO:3002658 APH(6)-Ib APH(6)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. glaucescens. PMID:3039305 APH(6)-Ib APH(6)-Ic is a transposon-encoded aminoglycoside phosphotransferase in S. enterica, P. aeruginosa and E. coli. APH(6)-Ic sph str antibiotic_resistance ARO:3002659 APH(6)-Ic APH(6)-Ic is a transposon-encoded aminoglycoside phosphotransferase in S. enterica, P. aeruginosa and E. coli. PMID:15102449 PMID:3889831 APH(6)-Ic APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids, integrative conjugative elements and chromosomal genomic islands in K. pneumoniae, Salmonella spp., E. coli, Shigella flexneri, Providencia alcalifaciens, Pseudomonas spp., V. cholerae, Edwardsiella tarda, Pasteurella multocida and Aeromonas bestiarum. APH(6)-Id strB, orfI antibiotic_resistance ARO:3002660 APH(6)-Id APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids, integrative conjugative elements and chromosomal genomic islands in K. pneumoniae, Salmonella spp., E. coli, Shigella flexneri, Providencia alcalifaciens, Pseudomonas spp., V. cholerae, Edwardsiella tarda, Pasteurella multocida and Aeromonas bestiarum. PMID:15722395 PMID:18413319 PMID:19465049 PMID:2653965 APH(6)-Id APH(7'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. hygroscopicus. APH(7'')-Ia antibiotic_resistance ARO:3002661 APH(7'')-Ia APH(7'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. hygroscopicus. PMID:12627869 APH(7'')-Ia APH(9)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in L. pneumophila. PDB:3I0O APH(9)-Ia antibiotic_resistance ARO:3002662 APH(9)-Ia APH(9)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in L. pneumophila. PMID:9174205 APH(9)-Ia APH(9)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. flavopersicus. APH(9)-Ib spcN antibiotic_resistance ARO:3002663 APH(9)-Ib APH(9)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. flavopersicus. PMID:9245803 APH(9)-Ib NpmA is a plasmid-mediated aminoglycoside-resistance 16S rRNA methyltransferase by interfering with aminoglycoside binding with the A site of 16S rRNA through N-1 methylation at position A1408. npmA antibiotic_resistance ARO:3002665 npmA NpmA is a plasmid-mediated aminoglycoside-resistance 16S rRNA methyltransferase by interfering with aminoglycoside binding with the A site of 16S rRNA through N-1 methylation at position A1408. PMID:17875999 npmA RmtF is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. rmtF antibiotic_resistance ARO:3002666 rmtF RmtF is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. PMID:22547620 PMID:26488937 rmtF RmtD is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. rmtD antibiotic_resistance ARO:3002667 rmtD RmtD is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. PMID:17158944 PMID:18222955 rmtD RmtG is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. rmtG antibiotic_resistance ARO:3002668 rmtG RmtG is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. PMID:23459483 rmtG APH('')-Ig is a plasmid-encoded aminoglycoside phosphotransferase in Campylobacter coli. APH(2'')-Ig antibiotic_resistance ARO:3002669 APH(2'')-Ig APH('')-Ig is a plasmid-encoded aminoglycoside phosphotransferase in Campylobacter coli. PMID:23959310 APH(2'')-Ig cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. cat antibiotic_resistance ARO:3002670 cat cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. PMID:11553538 PMID:11677608 PMID:11735367 PMID:11743194 PMID:12603745 PMID:12726767 PMID:12732947 PMID:1406372 PMID:1461942 PMID:1517170 PMID:1650008 PMID:1713259 PMID:1929282 PMID:1929326 PMID:19459958 PMID:2013403 PMID:2227449 PMID:2697637 PMID:2993795 PMID:3110008 PMID:3860383 PMID:3865770 PMID:3900035 PMID:6950931 PMID:9349809 cat cat-TC is a plasmid-encoded variant of the cat gene found in Limosilactobacillus reuteri. Lreu_cat-TC antibiotic_resistance ARO:3002671 Limosilactobacillus reuteri cat-TC cat-TC is a plasmid-encoded variant of the cat gene found in Limosilactobacillus reuteri. PMID:8954883 Lreu_cat-TC cat86 is a chromosome-encoded variant of the cat gene found in Bacillus pumilus. Bpum_cat86 antibiotic_resistance ARO:3002672 Bacillus pumilus cat86 cat86 is a chromosome-encoded variant of the cat gene found in Bacillus pumilus. PMID:6315534 Bpum_cat86 catB is a chromosome-encoded variant of the cat gene found in Clostridium butyricum. Cbut_catB antibiotic_resistance ARO:3002674 Clostridium butyricum catB catB is a chromosome-encoded variant of the cat gene found in Clostridium butyricum. PMID:1489203 Cbut_catB catB2 is a plasmid-encoded variant of the cat gene found in Escherichia coli, Salmonella enteritidis and Pasteurella multocida. catB2 antibiotic_resistance ARO:3002675 catB2 catB2 is a plasmid-encoded variant of the cat gene found in Escherichia coli, Salmonella enteritidis and Pasteurella multocida. PMID:12089302 PMID:1314803 PMID:19719593 catB2 catB3 is a plasmid or chromosome-encoded variant of the cat gene found in Salmonella typhimurium, Acinetobacter baumannii and Escherichia coli. catB3 catB4 antibiotic_resistance ARO:3002676 catB3 catB3 is a plasmid or chromosome-encoded variant of the cat gene found in Salmonella typhimurium, Acinetobacter baumannii and Escherichia coli. PMID:12654674 PMID:12821475 PMID:7793874 PMID:9835490 catB3 catB6 is a plasmid-encoded variant of the cat gene found in Pseudomonas aeruginosa. Paer_catB6 antibiotic_resistance ARO:3002678 Pseudomonas aeruginosa catB6 catB6 is a plasmid-encoded variant of the cat gene found in Pseudomonas aeruginosa. PMID:10103196 Paer_catB6 catB7 is a chromosome-encoded variant of the cat gene found in Pseudomonas aeruginosa. Paer_catB7 antibiotic_resistance ARO:3002679 Pseudomonas aeruginosa catB7 catB7 is a chromosome-encoded variant of the cat gene found in Pseudomonas aeruginosa. PMID:10361706 PMID:10984043 Paer_catB7 catB8 is a plasmid or integron-encoded variant of the cat gene found in Klebsiella pneumoniae, Salmonella typhi and Pseudomonas aeruginosa. catB8 antibiotic_resistance ARO:3002680 catB8 catB8 is a plasmid or integron-encoded variant of the cat gene found in Klebsiella pneumoniae, Salmonella typhi and Pseudomonas aeruginosa. PMID:12760886 catB8 catB9 is a chromosome-encoded variant of the cat gene found in Vibrio cholerae. catB9 antibiotic_resistance ARO:3002681 catB9 catB9 is a chromosome-encoded variant of the cat gene found in Vibrio cholerae. PMID:10952301 PMID:11952913 catB9 catD is a chromosome and transposon-encoded variant of the cat gene found in Clostridioides difficile. catD antibiotic_resistance ARO:3002682 catD catD is a chromosome and transposon-encoded variant of the cat gene found in Clostridioides difficile. PMID:11069682 catD catA1 (formerly in CARD as catI) is a chromosome and transposon-encoded variant of the cat gene found in Escherichia coli and Acinetobacter baumannii. cat1 catA1 catI antibiotic_resistance ARO:3002683 catA1 catA1 (formerly in CARD as catI) is a chromosome and transposon-encoded variant of the cat gene found in Escherichia coli and Acinetobacter baumannii. PMID:1650008 PMID:390403 catA1 catII is a plasmid-encoded variant of the cat gene found in Haemophilus influenzae, Agrobacterium tumefaciens and Escherichia coli. catII antibiotic_resistance ARO:3002684 catII catII is a plasmid-encoded variant of the cat gene found in Haemophilus influenzae, Agrobacterium tumefaciens and Escherichia coli. PMID:2268278 catII catIII is a plasmid-encoded variant of the cat gene found in Shigella flexneri. catA3 catIII antibiotic_resistance ARO:3002685 catIII catIII is a plasmid-encoded variant of the cat gene found in Shigella flexneri. PMID:3048245 catIII catP is a transposon and chromosome-encoded variant of the cat gene found in Clostridium perfringens and Neisseria meningitidis. catP antibiotic_resistance ARO:3002686 catP catP is a transposon and chromosome-encoded variant of the cat gene found in Clostridium perfringens and Neisseria meningitidis. PMID:7565113 PMID:9744970 catP catQ is a chromosome-encoded variant of the cat gene found in Clostridium perfringens. catQ antibiotic_resistance ARO:3002687 catQ catQ is a chromosome-encoded variant of the cat gene found in Clostridium perfringens. PMID:2039197 catQ catS is a chromosome-encoded variant of the cat gene found in Streptococcus pyogenes. catS antibiotic_resistance ARO:3002688 catS catS is a chromosome-encoded variant of the cat gene found in Streptococcus pyogenes. PMID:8109922 catS Plasmid-encoded cat, or pp-cat, is a plasmid-encoded variant of the cat gene found in Photobacterium damselae subsp. piscicida. pp_cat antibiotic_resistance ARO:3002689 Plasmid-encoded cat (pp-cat) Plasmid-encoded cat, or pp-cat, is a plasmid-encoded variant of the cat gene found in Photobacterium damselae subsp. piscicida. PMID:8271973 pp_cat cmlR is a plasmid or chromosome-encoded chloramphenicol resistance determinant (putative transmembrane protein) that is found in Escherichia coli and Streptomyces lividans. Sliv_cmlR antibiotic_resistance ARO:3002690 Streptomyces lividans cmlR cmlR is a plasmid or chromosome-encoded chloramphenicol resistance determinant (putative transmembrane protein) that is found in Escherichia coli and Streptomyces lividans. PMID:1779766 PMID:3011609 Sliv_cmlR cmlA is a plasmid-encoded chloramphenicol exporter that is found in Salmonella typhimurium. Sent_cmlA antibiotic_resistance ARO:3002691 Salmonella enterica cmlA cmlA is a plasmid-encoded chloramphenicol exporter that is found in Salmonella typhimurium. PMID:11959555 Sent_cmlA cmlA1 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa and Klebsiella pneumoniae. cmlA1 antibiotic_resistance ARO:3002693 cmlA1 cmlA1 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa and Klebsiella pneumoniae. PMID:11600350 PMID:12936998 PMID:1648560 PMID:1658833 cmlA1 cmlA4 is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella pneumoniae. cmlA4 antibiotic_resistance ARO:3002694 cmlA4 cmlA4 is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella pneumoniae. PMID:10681329 cmlA4 cmlA5 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Escherichia coli. cmlA5 cmlA7 antibiotic_resistance ARO:3002695 cmlA5 cmlA5 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Escherichia coli. PMID:10049269 PMID:19719593 cmlA5 cmlA6 is a plasmid-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa. cmlA6 antibiotic_resistance ARO:3002696 cmlA6 cmlA6 is a plasmid-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa. PMID:11353602 cmlA6 cmlB is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella aerogenes. cmlA2 cmlB antibiotic_resistance ARO:3002698 cmlB cmlB is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella aerogenes. PMID:9756755 cmlB cmlB1 is a plasmid-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica. cmlB1 antibiotic_resistance ARO:3002699 cmlB1 cmlB1 is a plasmid-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica. PMID:17224413 cmlB1 cmlv is a chromosome-encoded chloramphenicol phoshotransferase that is found in Streptomyces venezuelae. PDB:1QHN cmlv antibiotic_resistance ARO:3002700 cmlv cmlv is a chromosome-encoded chloramphenicol phoshotransferase that is found in Streptomyces venezuelae. PMID:7592948 cmlv cmr is a plasmid-encoded chloramphenicol exporter that is found in Rhodococcus fascians and Corynebacterium glutamicum. Rfas_cmr antibiotic_resistance ARO:3002701 Rhodococcus fascians cmr cmr is a plasmid-encoded chloramphenicol exporter that is found in Rhodococcus fascians and Corynebacterium glutamicum. PMID:1406276 Rfas_cmr cmrA is a transposon-encoded chloramphenicol exporter that is found in Rhodococcus rhodochrous. cmrA antibiotic_resistance ARO:3002702 cmrA cmrA is a transposon-encoded chloramphenicol exporter that is found in Rhodococcus rhodochrous. PMID:9226278 cmrA cmx is a plasmid or transposon-encoded chloramphenicol exporter that is found in Corynebacterium striatum and Pseudomonas aeruginosa. cmx antibiotic_resistance ARO:3002703 cmx cmx is a plasmid or transposon-encoded chloramphenicol exporter that is found in Corynebacterium striatum and Pseudomonas aeruginosa. PMID:8834878 PMID:9735314 cmx fexA is a plasmid-encoded chloramphenicol exporter that is found in Mammaliicoccus lentus. fexA antibiotic_resistance ARO:3002704 fexA fexA is a plasmid-encoded chloramphenicol exporter that is found in Mammaliicoccus lentus. PMID:14742219 fexA floR is a plasmid or chromosome-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica subsp. enterica serovar Typhimurium str. DT104 and Vibrio cholerae. floR antibiotic_resistance ARO:3002705 floR floR is a plasmid or chromosome-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica subsp. enterica serovar Typhimurium str. DT104 and Vibrio cholerae. PMID:10339826 PMID:10991873 PMID:11101601 PMID:11451703 PMID:11544236 PMID:11600347 PMID:12107144 PMID:12493808 PMID:14645321 PMID:17224413 PMID:19292580 floR Mycobacterium tuberculosis embC mutations at codon 270 confer resistance to ethambutol. antibiotic_resistance ARO:3002706 ethambutol resistant embC Mycobacterium tuberculosis embC mutations at codon 270 confer resistance to ethambutol. PMID:19112008 QnrA1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. QnrA1 antibiotic_resistance ARO:3002707 QnrA1 QnrA1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. PMID:11943863 QnrA1 QnrA2 is a plasmid-mediated quinolone resistance protein found in Klebsiella oxytoca. QnrA2 antibiotic_resistance ARO:3002708 QnrA2 QnrA2 is a plasmid-mediated quinolone resistance protein found in Klebsiella oxytoca. PMID:16020539 QnrA2 QnrA3 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. QnrA3 antibiotic_resistance ARO:3002709 QnrA3 QnrA3 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. PMID:16048974 QnrA3 QnrA4 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. QnrA4 antibiotic_resistance ARO:3002710 QnrA4 QnrA4 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. PMID:16048974 QnrA4 QnrA5 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. QnrA5 antibiotic_resistance ARO:3002711 QnrA5 QnrA5 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. PMID:16048974 QnrA5 QnrA6 is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis. QnrA6 antibiotic_resistance ARO:3002712 QnrA6 QnrA6 is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis. PMID:16961639 QnrA6 QnrA7 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. QnrA7 antibiotic_resistance ARO:3002713 QnrA7 QnrA7 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. PMID:34914577 QnrA7 QnrB1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. QnrB1 antibiotic_resistance ARO:3002714 QnrB1 QnrB1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. PMID:16569827 QnrB1 QnrB2 is a plasmid-mediated quinolone resistance protein found in Citrobacter koseri. QnrB2 antibiotic_resistance ARO:3002715 QnrB2 QnrB2 is a plasmid-mediated quinolone resistance protein found in Citrobacter koseri. PMID:16569827 QnrB2 QnrB3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB3 antibiotic_resistance ARO:3002716 QnrB3 QnrB3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:16870791 QnrB3 QnrB4 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB4 antibiotic_resistance ARO:3002718 QnrB4 QnrB4 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:16870791 QnrB4 QnrB5 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. QnrB5 antibiotic_resistance ARO:3002719 QnrB5 QnrB5 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. PMID:16804843 QnrB5 QnrB6 is a plasmid-mediated quinolone resistance protein found in Pantoea agglomerans. QnrB6 antibiotic_resistance ARO:3002720 QnrB6 QnrB6 is a plasmid-mediated quinolone resistance protein found in Pantoea agglomerans. PMID:19392890 QnrB6 QnrB7 is a plasmid-mediated quinolone resistance protein found in Enterobacter cloacae. QnrB7 antibiotic_resistance ARO:3002721 QnrB7 QnrB7 is a plasmid-mediated quinolone resistance protein found in Enterobacter cloacae. PMID:17561500 QnrB7 QnrB8 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB8 antibiotic_resistance ARO:3002722 QnrB8 QnrB8 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:17561500 QnrB8 QnrB9 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB9 antibiotic_resistance ARO:3002723 QnrB9 QnrB9 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:24093472 QnrB9 QnrB10 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB10 antibiotic_resistance ARO:3002724 QnrB10 QnrB10 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:17938184 QnrB10 QnrB11 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB11 antibiotic_resistance ARO:3002725 QnrB11 QnrB11 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:18426894 QnrB11 QnrB12 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. QnrB12 antibiotic_resistance ARO:3002726 QnrB12 QnrB12 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. PMID:18086833 QnrB12 QnrB13 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB13 antibiotic_resistance ARO:3002727 QnrB13 QnrB13 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:18725444 QnrB13 QnrB14 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB14 antibiotic_resistance ARO:3002728 QnrB14 QnrB14 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:18725444 QnrB14 QnrB15 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB15 antibiotic_resistance ARO:3002730 QnrB15 QnrB15 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:18725444 QnrB15 QnrB16 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB16 antibiotic_resistance ARO:3002731 QnrB16 QnrB16 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:19392890 QnrB16 QnrB17 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB17 antibiotic_resistance ARO:3002732 QnrB17 QnrB17 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:22850691 QnrB17 QnrB18 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB18 antibiotic_resistance ARO:3002733 QnrB18 QnrB18 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:22731858 QnrB18 QnrB19 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB19 antibiotic_resistance ARO:3002734 QnrB19 QnrB19 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:18519717 QnrB19 QnrB20 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB20 antibiotic_resistance ARO:3002735 QnrB20 QnrB20 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:18993034 QnrB20 QnrB21 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB21 antibiotic_resistance ARO:3002736 QnrB21 QnrB21 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:18426894 QnrB21 QnrB22 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. QnrB22 antibiotic_resistance ARO:3002737 QnrB22 QnrB22 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. PMID:20421404 QnrB22 QnrB23 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB23 antibiotic_resistance ARO:3002738 QnrB23 QnrB23 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:20421404 QnrB23 QnrB24 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB24 antibiotic_resistance ARO:3002739 QnrB24 QnrB24 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21816943 QnrB24 QnrB25 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB25 antibiotic_resistance ARO:3002740 QnrB25 QnrB25 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:22850691 QnrB25 QnrB26 is a plasmid-mediated quinolone resistance protein found in Proteus vulgaris. QnrB26 antibiotic_resistance ARO:3002741 QnrB26 QnrB26 is a plasmid-mediated quinolone resistance protein found in Proteus vulgaris. PMID:23844849 QnrB26 QnrB27 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB27 antibiotic_resistance ARO:3002742 QnrB27 QnrB27 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:21830908 QnrB27 QnrB28 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB28 antibiotic_resistance ARO:3002743 QnrB28 QnrB28 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21830908 QnrB28 QnrB29 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB29 antibiotic_resistance ARO:3002744 QnrB29 QnrB29 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21830908 QnrB29 QnrB30 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB30 antibiotic_resistance ARO:3002745 QnrB30 QnrB30 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:21830908 QnrB30 QnrB31 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. QnrB31 antibiotic_resistance ARO:3002746 QnrB31 QnrB31 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. PMID:21816942 QnrB31 QnrB32 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB32 antibiotic_resistance ARO:3002747 QnrB32 QnrB32 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21844311 QnrB32 QnrB33 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB33 antibiotic_resistance ARO:3002748 QnrB33 QnrB33 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:21844311 QnrB33 QnrB34 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. QnrB34 antibiotic_resistance ARO:3002749 QnrB34 QnrB34 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. PMID:21844311 QnrB34 QnrB35 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB35 antibiotic_resistance ARO:3002750 QnrB35 QnrB35 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21844311 QnrB35 QnrB36 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB36 antibiotic_resistance ARO:3002751 QnrB36 QnrB36 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21844311 QnrB36 QnrB37 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB37 antibiotic_resistance ARO:3002752 QnrB37 QnrB37 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21844311 QnrB37 QnrB38 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB38 antibiotic_resistance ARO:3002753 QnrB38 QnrB38 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21844311 QnrB38 QnrB39 is a chromosome-mediated quinolone resistance protein found in Citrobacter youngae. QnrB39 antibiotic_resistance ARO:3002754 QnrB39 QnrB39 is a chromosome-mediated quinolone resistance protein found in Citrobacter youngae. PMID:21844311 QnrB39 QnrB40 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB40 antibiotic_resistance ARO:3002755 QnrB40 QnrB40 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:21830908 QnrB40 QnrB41 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB41 antibiotic_resistance ARO:3002756 QnrB41 QnrB41 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21830908 QnrB41 QnrB42 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. QnrB42 antibiotic_resistance ARO:3002757 QnrB42 QnrB42 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. PMID:22850691 QnrB42 QnrB43 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB43 antibiotic_resistance ARO:3002758 QnrB43 QnrB43 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:23162539 QnrB43 QnrB44 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB44 antibiotic_resistance ARO:3002759 QnrB44 QnrB44 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:26207437 QnrB44 QnrB45 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB45 antibiotic_resistance ARO:3002760 QnrB45 QnrB45 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:23162539 QnrB45 QnrB46 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB46 QnrB53 antibiotic_resistance ARO:3002761 QnrB46 QnrB46 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:21816942 QnrB46 QnrB47 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB47 QnrB51 antibiotic_resistance ARO:3002762 QnrB47 QnrB47 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:24247140 QnrB47 QnrB48 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB48 antibiotic_resistance ARO:3002763 QnrB48 QnrB48 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:23162539 QnrB48 QnrB49 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB49 antibiotic_resistance ARO:3002764 QnrB49 QnrB49 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:22731858 QnrB49 QnrB50 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB50 antibiotic_resistance ARO:3002765 QnrB50 QnrB50 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:23162539 QnrB50 QnrB54 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB54 antibiotic_resistance ARO:3002767 QnrB54 QnrB54 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:25512409 QnrB54 QnrB55 is a plasmid-mediated quinolone resistance protein found in Raoultella terrigena. QnrB55 antibiotic_resistance ARO:3002768 QnrB55 QnrB55 is a plasmid-mediated quinolone resistance protein found in Raoultella terrigena. PMID:27192164 QnrB55 QnrB56 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB56 antibiotic_resistance ARO:3002769 QnrB56 QnrB56 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:26169406 QnrB56 QnrB57 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB57 antibiotic_resistance ARO:3002770 QnrB57 QnrB57 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:26169406 QnrB57 QnrB58 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB58 antibiotic_resistance ARO:3002771 QnrB58 QnrB58 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:26169406 QnrB58 QnrB59 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB59 antibiotic_resistance ARO:3002772 QnrB59 QnrB59 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:18426894 QnrB59 QnrB60 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB60 antibiotic_resistance ARO:3002773 QnrB60 QnrB60 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:23529729 QnrB60 QnrB61 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB61 antibiotic_resistance ARO:3002774 QnrB61 QnrB61 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:23529729 QnrB61 QnrB62 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB62 antibiotic_resistance ARO:3002775 QnrB62 QnrB62 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:27572415 QnrB62 QnrB64 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB64 antibiotic_resistance ARO:3002776 QnrB64 QnrB64 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:24247140 QnrB64 QnrB65 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB65 antibiotic_resistance ARO:3002777 QnrB65 QnrB65 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:24247140 QnrB65 QnrB66 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB66 antibiotic_resistance ARO:3002778 QnrB66 QnrB66 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:24247140 QnrB66 QnrB67 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB67 antibiotic_resistance ARO:3002779 QnrB67 QnrB67 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:24247140 QnrB67 QnrB68 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB68 antibiotic_resistance ARO:3002780 QnrB68 QnrB68 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:24247140 QnrB68 QnrB69 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB69 antibiotic_resistance ARO:3002781 QnrB69 QnrB69 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:24247140 QnrB69 QnrB70 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB70 antibiotic_resistance ARO:3002782 QnrB70 QnrB70 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:24247140 QnrB70 QnrB71 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB71 antibiotic_resistance ARO:3002783 QnrB71 QnrB71 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:24247140 QnrB71 QnrB72 is a plasmid-mediated quinolone resistance protein found in Citrobacter sp. TR21_24. QnrB72 antibiotic_resistance ARO:3002784 QnrB72 QnrB72 is a plasmid-mediated quinolone resistance protein found in Citrobacter sp. TR21_24. PMID:26169406 QnrB72 QnrB73 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB73 antibiotic_resistance ARO:3002785 QnrB73 QnrB73 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:26169406 QnrB73 QnrB74 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB74 antibiotic_resistance ARO:3002786 QnrB74 QnrB74 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:26259681 QnrB74 QnrC is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis. QnrC antibiotic_resistance ARO:3002787 QnrC QnrC is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis. PMID:19258263 QnrC QnrD1 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. QnrD1 antibiotic_resistance ARO:3002788 QnrD1 QnrD1 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. PMID:19029321 QnrD1 QnrD2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. QnrD2 antibiotic_resistance ARO:3002789 QnrD2 QnrD2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. PMID:24733466 QnrD2 QnrS1 is a plasmid-mediated quinolone resistance protein found in Shigella flexneri. QnrS1 antibiotic_resistance ARO:3002790 QnrS1 QnrS1 is a plasmid-mediated quinolone resistance protein found in Shigella flexneri. PMID:15673773 QnrS1 QnrS2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. QnrS2 antibiotic_resistance ARO:3002791 QnrS2 QnrS2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. PMID:16804843 QnrS2 QnrS3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrS3 antibiotic_resistance ARO:3002792 QnrS3 QnrS3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:18573620 QnrS3 QnrS4 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. QnrS4 antibiotic_resistance ARO:3002793 QnrS4 QnrS4 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. PMID:19056747 QnrS4 QnrS5 is a plasmid-mediated quinolone resistance protein found in Aeromonas sobria. QnrS5 antibiotic_resistance ARO:3002794 QnrS5 QnrS5 is a plasmid-mediated quinolone resistance protein found in Aeromonas sobria. PMID:22024339 QnrS5 QnrS6 is a plasmid-mediated quinolone resistance protein found in Aeromonas hydrophila. QnrS6 antibiotic_resistance ARO:3002795 QnrS6 QnrS6 is a plasmid-mediated quinolone resistance protein found in Aeromonas hydrophila. PMID:22024339 QnrS6 QnrS7 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrS7 antibiotic_resistance ARO:3002796 QnrS7 QnrS7 QnrS8 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. QnrS8 antibiotic_resistance ARO:3002797 QnrS8 QnrS8 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. PMID:26618005 QnrS8 QnrS9 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. QnrS9 antibiotic_resistance ARO:3002798 QnrS9 QnrS9 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. PMID:24458509 QnrS9 QnrVC1 is an integron-mediated quinolone resistance protein found in Vibrio cholerae. QnrVC1 antibiotic_resistance ARO:3002799 QnrVC1 QnrVC1 is an integron-mediated quinolone resistance protein found in Vibrio cholerae. PMID:18598639 QnrVC1 QnrVC3 is an integron-mediated quinolone resistance protein found in Vibrio cholerae. QnrVC3 antibiotic_resistance ARO:3002800 QnrVC3 QnrVC3 is an integron-mediated quinolone resistance protein found in Vibrio cholerae. PMID:20516288 QnrVC3 QnrVC4 is an integron-mediated quinolone resistance protein found in Aeromonas punctata. QnrVC4 antibiotic_resistance ARO:3002801 QnrVC4 QnrVC4 is an integron-mediated quinolone resistance protein found in Aeromonas punctata. PMID:23098826 QnrVC4 QnrVC5 is an integron-mediated quinolone resistance protein found in Vibrio fluvialis. QnrVC5 antibiotic_resistance ARO:3002802 QnrVC5 QnrVC5 is an integron-mediated quinolone resistance protein found in Vibrio fluvialis. PMID:23800600 QnrVC5 QnrVC6 is an integron-mediated quinolone resistance protein found in Acinetobacter baumannii. QnrVC6 antibiotic_resistance ARO:3002803 QnrVC6 QnrVC6 is an integron-mediated quinolone resistance protein found in Acinetobacter baumannii. PMID:23800600 QnrVC6 An enzyme that confers resistance to fosfomycin in Enterobacter cloacae by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. FosA2 antibiotic_resistance ARO:3002804 FosA2 An enzyme that confers resistance to fosfomycin in Enterobacter cloacae by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. PMID:21392044 FosA2 murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance. antibiotic_resistance ARO:3002811 antibiotic-resistant murA transferase murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance. PMID:20071153 pp-flo is a plasmid chloramphenicol exporter that is found in Photobacterium damselae subsp. piscicida. pp-flo antibiotic_resistance ARO:3002812 pp-flo pp-flo is a plasmid chloramphenicol exporter that is found in Photobacterium damselae subsp. piscicida. PMID:8908612 pp-flo lmrB is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Bacillus subtilis. lmrB antibiotic_resistance ARO:3002813 lmrB lmrB is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Bacillus subtilis. PMID:15317768 lmrB clbA is a plasmid-encoded cfr gene found in Bacillus velezensis (Bacillus amyloliquefaciens subsp. plantarum). clbA antibiotic_resistance ARO:3002814 clbA clbA is a plasmid-encoded cfr gene found in Bacillus velezensis (Bacillus amyloliquefaciens subsp. plantarum). PMID:22547628 clbA clbB is a plasmid-encoded cfr gene found in Bacillus brevis. clbB antibiotic_resistance ARO:3002815 clbB clbB is a plasmid-encoded cfr gene found in Bacillus brevis. PMID:22547628 PMID:29259290 clbB clbC is a plasmid-encoded cfr gene found in Alkalihalobacillus clausii. clbC antibiotic_resistance ARO:3002816 clbC clbC is a plasmid-encoded cfr gene found in Alkalihalobacillus clausii. PMID:22547628 clbC carA is an ABC-F subfamily protein involved in macrolide resistance. It is found in Streptomyces thermotolerans. carA antibiotic_resistance ARO:3002817 carA carA is an ABC-F subfamily protein involved in macrolide resistance. It is found in Streptomyces thermotolerans. PMID:1612454 carA MsrB is an ABC-F subfamily protein expressed to Staphylococcus species that confers resistance to erythromycin and streptogramin B antibiotics. It is associated with plasmid DNA. msr(B) msrB antibiotic_resistance ARO:3002818 msrB MsrB is an ABC-F subfamily protein expressed to Staphylococcus species that confers resistance to erythromycin and streptogramin B antibiotics. It is associated with plasmid DNA. PMID:1426997 msrB msrC is a chromosomal-encoded ABC-F subfamily protein expressed in Enterococcus faecium that confers resistance to erythromycin and other macrolide and streptogramin B antibiotics. msr(C) msrC antibiotic_resistance ARO:3002819 msrC msrC is a chromosomal-encoded ABC-F subfamily protein expressed in Enterococcus faecium that confers resistance to erythromycin and other macrolide and streptogramin B antibiotics. PMID:11120975 msrC ErmH is a plasmid-mediated methyltransferase found in Streptomyces thermotolerans. ErmH carB antibiotic_resistance ARO:3002823 ErmH ErmH is a plasmid-mediated methyltransferase found in Streptomyces thermotolerans. PMID:3036668 ErmH ErmV is a plasmid-mediated methyltransferase found in Streptomyces viridochromogenes. ErmV ermSV antibiotic_resistance ARO:3002824 ErmV ErmV is a plasmid-mediated methyltransferase found in Streptomyces viridochromogenes. PMID:6163765 PMID:9055987 ErmV ErmY is a plasmid-mediated methyltransferase found in Staphylococcus aureus. ErmGM ErmY antibiotic_resistance ARO:3002825 ErmY ErmY is a plasmid-mediated methyltransferase found in Staphylococcus aureus. PMID:9809423 ErmY EreA2 is an integron-encoded erythromycin esterase that hydrolyses the drug's lactone ring. EreA2 is found in Providencia stuartii. Ere(A2) EreA2 antibiotic_resistance ARO:3002826 EreA2 EreA2 is an integron-encoded erythromycin esterase that hydrolyses the drug's lactone ring. EreA2 is found in Providencia stuartii. PMID:12654734 EreA2 tlrC is an ABC-F subfamily protein found in Streptomyces fradiae and confers resistance to mycinamicin, tylosin and lincosamides. tlrC is found in the tylosin biosynthetic cluster and is one mechanism by which S. fradiae protects itself from self-destruction when producing this macrolide. tlrC antibiotic_resistance ARO:3002827 tlrC tlrC is an ABC-F subfamily protein found in Streptomyces fradiae and confers resistance to mycinamicin, tylosin and lincosamides. tlrC is found in the tylosin biosynthetic cluster and is one mechanism by which S. fradiae protects itself from self-destruction when producing this macrolide. PMID:1864505 tlrC srmB is an ABC-F subfamily protein found in Streptomyces ambofaciens that confers resistance to spiramycin. srmB antibiotic_resistance ARO:3002828 srmB srmB is an ABC-F subfamily protein found in Streptomyces ambofaciens that confers resistance to spiramycin. PMID:1612454 srmB vgaA is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. vgaA antibiotic_resistance ARO:3002829 vgaA vgaA is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. PMID:23796922 vgaA vgaALC is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. vgaALC antibiotic_resistance ARO:3002830 vgaALC vgaALC is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. PMID:17015629 vgaALC vgaC is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. vgaC antibiotic_resistance ARO:3002831 vgaC vgaC is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. PMID:19470508 PMID:20876620 vgaC vgaD is an ABC-F subfamily protein expressed in Enterococcus faecium that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. vgaD antibiotic_resistance ARO:3002832 vgaD vgaD is an ABC-F subfamily protein expressed in Enterococcus faecium that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. PMID:20713681 vgaD vgaE is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with transposon DNA. vgaE antibiotic_resistance ARO:3002833 vgaE vgaE is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with transposon DNA. PMID:21768510 vgaE lnuA is a plasmid-mediated nucleotidyltransferase found in Staphylococcus chromogenes. linA lnuA antibiotic_resistance ARO:3002835 lnuA lnuA is a plasmid-mediated nucleotidyltransferase found in Staphylococcus chromogenes. PMID:17329268 lnuA lnuB is a plasmid-mediated nucleotidyltransferase found in Streptococcus lutetiensis. linB lnuB antibiotic_resistance ARO:3002836 lnuB lnuB is a plasmid-mediated nucleotidyltransferase found in Streptococcus lutetiensis. PMID:10103201 PMID:24048528 lnuB lnuC is a transposon-mediated nucleotidyltransferase found in Streptococcus agalactiae. linC lnuC antibiotic_resistance ARO:3002837 lnuC lnuC is a transposon-mediated nucleotidyltransferase found in Streptococcus agalactiae. PMID:15980341 lnuC lnuD is a plasmid-mediated nucleotidyltransferase found in Streptococcus uberis. linD lnuD antibiotic_resistance ARO:3002838 lnuD lnuD is a plasmid-mediated nucleotidyltransferase found in Streptococcus uberis. PMID:18086844 lnuD lnuF is an integron-mediated nucleotidyltransferase found in Escherichia coli. linF lnuF antibiotic_resistance ARO:3002839 lnuF lnuF is an integron-mediated nucleotidyltransferase found in Escherichia coli. PMID:15242512 lnuF vatA is a plasmid-mediated acetyltransferase found in Staphylococcus aureus. vat(A) vatA antibiotic_resistance ARO:3002840 vatA vatA is a plasmid-mediated acetyltransferase found in Staphylococcus aureus. PMID:8344533 vatA vatB is a plasmid-mediated acetyltransferase found in Staphylococcus aureus. vat(B) vatB antibiotic_resistance ARO:3002841 vatB vatB is a plasmid-mediated acetyltransferase found in Staphylococcus aureus. PMID:8540711 vatB vatC is a plasmid-mediated acetyltransferase found in Staphylococcus cohnii. vat(C) vatC antibiotic_resistance ARO:3002842 vatC vatC is a plasmid-mediated acetyltransferase found in Staphylococcus cohnii. PMID:9661023 vatC vatD is a transposon-mediated acetyltransferase found in Enterococcus faecium. vat(D) vatD antibiotic_resistance ARO:3002843 vatD vatD is a transposon-mediated acetyltransferase found in Enterococcus faecium. PMID:11600385 vatD vatE is a transposon-mediated acetyltransferase found in Enterococcus faecium. satG vat(E) vatE antibiotic_resistance ARO:3002844 vatE vatE is a transposon-mediated acetyltransferase found in Enterococcus faecium. PMID:11023445 vatE vatH is a plasmid-mediated acetyltransferase found in Enterococcus faecium. vatG vatH antibiotic_resistance ARO:3002845 vatH vatH is a plasmid-mediated acetyltransferase found in Enterococcus faecium. PMID:20713681 vatH arr-1 is a chromosome-encoded ribosyltransferase found in Mycolicibacterium smegmatis. arr-1 antibiotic_resistance ARO:3002846 arr-1 arr-1 is a chromosome-encoded ribosyltransferase found in Mycolicibacterium smegmatis. PMID:9371349 arr-1 arr-2 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. arr-2 antibiotic_resistance ARO:3002847 arr-2 arr-2 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. PMID:10103210 arr-2 arr-3 is a plasmid-encoded ribosyltransferase found in Vibrio fluvialis. arr-3 arr-6 antibiotic_resistance ARO:3002848 arr-3 arr-3 is a plasmid-encoded ribosyltransferase found in Vibrio fluvialis. PMID:21683552 arr-3 arr-4 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. arr-4 antibiotic_resistance ARO:3002849 arr-4 arr-4 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. PMID:18299416 arr-4 arr-5 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. arr-5 antibiotic_resistance ARO:3002850 arr-5 arr-5 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. PMID:18299416 arr-5 arr-7 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. arr-7 antibiotic_resistance ARO:3002852 arr-7 arr-7 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. PMID:19884381 arr-7 arr-8 is an integron-encoded ribosyltransferase found in Klebsiella oxytoca. arr-8 antibiotic_resistance ARO:3002853 arr-8 arr-8 is an integron-encoded ribosyltransferase found in Klebsiella oxytoca. PMID:23752512 arr-8 dfrA1 is an integron-encoded dihydrofolate reductase. dfr1 dfrA1 dhfrI antibiotic_resistance ARO:3002854 dfrA1 dfrA1 is an integron-encoded dihydrofolate reductase. PMID:15388464 dfrA1 dfrA24 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA24 antibiotic_resistance ARO:3002856 dfrA24 dfrA24 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:17307981 dfrA24 dfrA26 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA26 antibiotic_resistance ARO:3002857 dfrA26 dfrA26 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:17307981 dfrA26 dfrA12 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. dfrA12 antibiotic_resistance ARO:3002858 dfrA12 dfrA12 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. PMID:12183252 PMID:20660690 dfrA12 dfrA14 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA14 antibiotic_resistance ARO:3002859 dfrA14 dfrA14 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:18794381 dfrA14 dfrA17 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA17 antibiotic_resistance ARO:3002860 dfrA17 dfrA17 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:20236427 dfrA17 dfrA5 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. dfrA5 antibiotic_resistance ARO:3002861 dfrA5 dfrA5 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. PMID:12183252 dfrA5 dfrA7 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA7 antibiotic_resistance ARO:3002862 dfrA7 dfrA7 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:19229487 dfrA7 dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica. dfrA8 dhfrIIIc antibiotic_resistance ARO:3002863 dfrA8 dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica. PMID:32849452 dfrA8 A plasmid-associated trimethoprim-resistant dihydrofolate reductase detected in Bordetella bronchispetica on pKBB958. dfr2a dfrB1 dfrII antibiotic_resistance ARO:3002864 dfrB1 A plasmid-associated trimethoprim-resistant dihydrofolate reductase detected in Bordetella bronchispetica on pKBB958. PMID:16046466 dfrB1 dfrC is a chromosome-encoded dihydrofolate reductase found in Staphylococcus aureus. dfrC antibiotic_resistance ARO:3002865 dfrC dfrC is a chromosome-encoded dihydrofolate reductase found in Staphylococcus aureus. PMID:7768789 dfrC dfrD is a plasmid-encoded dihydrofolate reductase found in Listeria monocytogenes. dfrD antibiotic_resistance ARO:3002866 dfrD dfrD is a plasmid-encoded dihydrofolate reductase found in Listeria monocytogenes. PMID:9145882 dfrD dfrF is a chromosome-encoded dihydrofolate reductase found in Streptococcus pyogenes. dfrF antibiotic_resistance ARO:3002867 dfrF dfrF is a chromosome-encoded dihydrofolate reductase found in Streptococcus pyogenes. PMID:24492367 dfrF dfrG is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus. dfrG antibiotic_resistance ARO:3002868 dfrG dfrG is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus. PMID:16127079 dfrG dfrK is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus. dfrK antibiotic_resistance ARO:3002869 dfrK dfrK is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus. PMID:22718530 dfrK tet(34) causes the activation of Mg2+-dependent purine nucleotide synthesis, which protects the protein synthesis pathway. It is found in Gram-negative Vibrio. tet(34) tet34 antibiotic_resistance ARO:3002870 tet(34) tet(34) causes the activation of Mg2+-dependent purine nucleotide synthesis, which protects the protein synthesis pathway. It is found in Gram-negative Vibrio. PMID:11959596 tet(34) tet(37) is a chromosome-encoded oxidoreductase isolated from an uncultured bacterium that confers resistance to tetracycline. tet(37) tet37 antibiotic_resistance ARO:3002871 tet(37) tet(37) is a chromosome-encoded oxidoreductase isolated from an uncultured bacterium that confers resistance to tetracycline. PMID:12654685 tet(37) An enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. FosA3 antibiotic_resistance ARO:3002872 FosA3 An enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. PMID:26488485 FosA3 A thiol transferase that leads to the resistance of fosfomycin in Enterococcus faecium. Contrasting FosA, FosB is dependent on the cofactor Magnesium (II) and uses either bacillithiol to open up the epoxide ring of fosfomycin. FosB3 antibiotic_resistance ARO:3002873 FosB3 A thiol transferase that leads to the resistance of fosfomycin in Enterococcus faecium. Contrasting FosA, FosB is dependent on the cofactor Magnesium (II) and uses either bacillithiol to open up the epoxide ring of fosfomycin. PMID:24205114 FosB3 FosC2 is an enzyme that phosphorylates fosfomycin to confer resistance in Escherichia coli. FosC2 antibiotic_resistance ARO:3002874 FosC2 FosC2 is an enzyme that phosphorylates fosfomycin to confer resistance in Escherichia coli. PMID:20404116 FosC2 dfrE is a chromosome-encoded dihydrofolate reductase found in Enterococcus faecalis. dfrE antibiotic_resistance ARO:3002875 dfrE dfrE is a chromosome-encoded dihydrofolate reductase found in Enterococcus faecalis. PMID:9869579 dfrE Arabinofuranosyltransferases allow for the polymerization of arabinose to form arabinan. Arabinan is required for formation of mycobacterial cell walls and arabinosyltransferases are targets of the drug ethambutol. Mutations in these genes can confer resistance to ethambutol. antibiotic_resistance ARO:3002876 ethambutol resistant aftA Bacillus cereus beta-lactamase I is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in the Bacillus cereus strain 569/H/9. BcI antibiotic_resistance ARO:3002877 BcI Bacillus cereus beta-lactamase I is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in the Bacillus cereus strain 569/H/9. PMID:29551437 BcI Bacillus cereus beta-lactamase II is a zinc metallo-beta-lactamase that hydrolyzes a large number of penicillins and cephalosporins in the Bacillus cereus strain 5/B/6. BcII antibiotic_resistance ARO:3002878 BcII Bacillus cereus beta-lactamase II is a zinc metallo-beta-lactamase that hydrolyzes a large number of penicillins and cephalosporins in the Bacillus cereus strain 5/B/6. PMID:7588620 BcII linG is an integron-associated gene cassette, with aadA2, encoding a lincosomide nucleotidyltransferase found in Salmonella enterica. linG confers resistance to lincosomide antibiotics. linG antibiotic_resistance ARO:3002879 linG linG is an integron-associated gene cassette, with aadA2, encoding a lincosomide nucleotidyltransferase found in Salmonella enterica. linG confers resistance to lincosomide antibiotics. PMID:17005845 linG lmrC is an ABC-F subfamily protein that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD. lmrC ydaG antibiotic_resistance ARO:3002881 lmrC lmrC is an ABC-F subfamily protein that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD. PMID:16958846 lmrC lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC. lmrD ydbA antibiotic_resistance ARO:3002882 lmrD lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC. PMID:16958846 lmrD rgt1438 is a glycosyltransferase that confers rifampin resistance in Streptomyces. rgt1438 antibiotic_resistance ARO:3002883 rgt1438 rgt1438 is a glycosyltransferase that confers rifampin resistance in Streptomyces. PMID:22802246 rgt1438 iri is a monooxygenase that confers resistance to rifampin found in Rhodococcus hoagii. iri antibiotic_resistance ARO:3002884 iri iri is a monooxygenase that confers resistance to rifampin found in Rhodococcus hoagii. PMID:8980786 iri Streptomyces rimosus otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces rimosus. otr(A)S.rim antibiotic_resistance ARO:3002891 Streptomyces rimosus otr(A) Streptomyces rimosus otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces rimosus. PMID:1809836 otr(A)S.rim otr(B) is a tetracycline resistance efflux pump found in Streptomyces rimosus. otr(B) otrB tet347 antibiotic_resistance ARO:3002892 otr(B) otr(B) is a tetracycline resistance efflux pump found in Streptomyces rimosus. PMID:9867793 otr(B) tcr3 is a tetracycline efflux pump that confers self-resistance to Kitasatospora aureofaciens. tcr3 trcC antibiotic_resistance ARO:3002893 tcr3 tcr3 is a tetracycline efflux pump that confers self-resistance to Kitasatospora aureofaciens. PMID:8534971 tcr3 otr(C) is a tetracycline resistance efflux pump found in Streptomyces rimosus. otr(C) otrC antibiotic_resistance ARO:3002894 otr(C) otr(C) is a tetracycline resistance efflux pump found in Streptomyces rimosus. PMID:22906146 otr(C) SAT-2 is a plasmid-mediated streptothricin acetyltransferase, which confers resistance to streptothricin, a nucleoside antibiotic. Originally described from an E. coli plasmid sequence by Heim et al., 1989. SAT-2 antibiotic_resistance ARO:3002895 SAT-2 SAT-2 is a plasmid-mediated streptothricin acetyltransferase, which confers resistance to streptothricin, a nucleoside antibiotic. Originally described from an E. coli plasmid sequence by Heim et al., 1989. PMID:2157196 PMID:2550905 SAT-2 SAT-4 is a plasmid-mediated streptothricin acetyltransferase and streptothricin (a nucleoside antibiotic) resistant determinant. Originally described from a Campylobacter coli BE/G4 plasmid gene sequence by Jacob et al, 1994. SAT-4 antibiotic_resistance ARO:3002897 SAT-4 SAT-4 is a plasmid-mediated streptothricin acetyltransferase and streptothricin (a nucleoside antibiotic) resistant determinant. Originally described from a Campylobacter coli BE/G4 plasmid gene sequence by Jacob et al, 1994. PMID:8056285 SAT-4 SAT-3 is a plasmid-mediated streptothricin acetyltransferase and streptothricin resistance determinant. Originally described from an E. coli plasmid gene by Tietze and Brevet, 1995. SAT-3 antibiotic_resistance ARO:3002898 SAT-3 SAT-3 is a plasmid-mediated streptothricin acetyltransferase and streptothricin resistance determinant. Originally described from an E. coli plasmid gene by Tietze and Brevet, 1995. PMID:7640311 SAT-3 These genes are involved in activating and regulating transcription of gene clusters. antibiotic_resistance ARO:3002905 VanS-VanR two-component regulatory system These genes are involved in activating and regulating transcription of gene clusters. PMID:1556077 Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. antibiotic_resistance ARO:3002906 Van ligase Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. PMID:12019119 PMID:15980329 PMID:16323116 PMID:16723588 PMID:18458129 PMID:20733041 PMID:21807981 PMID:24342631 VanE is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. vanE antibiotic_resistance ARO:3002907 vanE VanE is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. PMID:12019119 vanE VanF is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance in Paenibacillus popilliae. vanF antibiotic_resistance ARO:3002908 vanF VanF is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance in Paenibacillus popilliae. PMID:15980329 vanF VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. vanG antibiotic_resistance ARO:3002909 vanG VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. PMID:12426332 PMID:16323116 vanG VanL is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. vanL antibiotic_resistance ARO:3002910 vanL VanL is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. PMID:18458129 vanL VanM is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. vanM antibiotic_resistance ARO:3002911 vanM VanM is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. PMID:20733041 vanM VanN is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecium. vanN antibiotic_resistance ARO:3002912 vanN VanN is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecium. PMID:21807981 vanN VanO is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. vanO antibiotic_resistance ARO:3002913 vanO VanO is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. PMID:24342631 vanO vanJ is a novel membrane protein that confers resistance to teicoplanin and its derivatives in Streptomyces coelicolor by recycling undecaprenol pyrophosphate during cell wall biosynthesis. vanJ antibiotic_resistance ARO:3002914 vanJ vanJ is a novel membrane protein that confers resistance to teicoplanin and its derivatives in Streptomyces coelicolor by recycling undecaprenol pyrophosphate during cell wall biosynthesis. PMID:15130128 PMID:22232274 vanJ VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance. antibiotic_resistance ARO:3002915 vanK VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance. PMID:15130128 PMID:15632111 vanV is an accessory protein of van operons, first identified in the vanB operon. It is not required for vancomycin resistance. antibiotic_resistance ARO:3002916 vanV vanV is an accessory protein of van operons, first identified in the vanB operon. It is not required for vancomycin resistance. PMID:21482081 Homologous to vanC, contains a D-Ala-D-Ser ligase. The plasmid-located vanM gene cluster is inducible and confers low resistance to vancomycin. vanN organisms remain susceptible to teicoplanin. Gene orientation: N(XY)TRS. vanN_cluster antibiotic_resistance ARO:3002917 glycopeptide resistance gene cluster VanN Homologous to vanC, contains a D-Ala-D-Ser ligase. The plasmid-located vanM gene cluster is inducible and confers low resistance to vancomycin. vanN organisms remain susceptible to teicoplanin. Gene orientation: N(XY)TRS. PMID:21807981 vanN_cluster Homologous to vanA, contains a D-Ala-D-Lac ligase. The chromosome-located vanO gene cluster is inducible. Not much is known about the biochemistry about the vanO gene cluster. Gene orientation: orf1 RS orf2 HOX. vanO_cluster antibiotic_resistance ARO:3002918 glycopeptide resistance gene cluster VanO Homologous to vanA, contains a D-Ala-D-Lac ligase. The chromosome-located vanO gene cluster is inducible. Not much is known about the biochemistry about the vanO gene cluster. Gene orientation: orf1 RS orf2 HOX. PMID:24342631 vanO_cluster Also known as vanRA, is a vanR variant found in the vanA gene cluster. vanR-A vanRA vanR_in_vanA_cl antibiotic_resistance ARO:3002919 vanR gene in vanA cluster Also known as vanRA, is a vanR variant found in the vanA gene cluster. PMID:16323116 PMID:8380148 vanR_in_vanA_cl Also known as vanRB, is a vanR variant found in the vanB gene cluster. vanR-B vanRB vanR_in_vanB_cl antibiotic_resistance ARO:3002921 vanR gene in vanB cluster Also known as vanRB, is a vanR variant found in the vanB gene cluster. PMID:16323116 PMID:8631706 vanR_in_vanB_cl Also known as vanRC, is a vanR variant found in the vanC gene cluster. vanR-C vanRC vanR_in_vanC_cl antibiotic_resistance ARO:3002922 vanR gene in vanC cluster Also known as vanRC, is a vanR variant found in the vanC gene cluster. PMID:10817725 PMID:16323116 vanR_in_vanC_cl Also known as vanRD, is a mutated vanR variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis. vanR-D vanRD vanR_in_vanD_cl antibiotic_resistance ARO:3002923 vanR gene in vanD cluster Also known as vanRD, is a mutated vanR variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis. PMID:12499162 PMID:16323116 vanR_in_vanD_cl Also known as vanRE, is a vanR variant found in the vanE gene cluster. vanR-E vanRE vanR_in_vanE_cl antibiotic_resistance ARO:3002924 vanR gene in vanE cluster Also known as vanRE, is a vanR variant found in the vanE gene cluster. PMID:12019119 vanR_in_vanE_cl Also known as vanRF, is a vanR variant found in the vanF gene cluster. vanR-F vanRF vanR_in_vanF_cl antibiotic_resistance ARO:3002925 vanR gene in vanF cluster Also known as vanRF, is a vanR variant found in the vanF gene cluster. PMID:15980329 vanR_in_vanF_cl Also known as vanRG, is a vanR variant found in the vanG gene cluster. vanR-G vanRG vanR_in_vanG_cl antibiotic_resistance ARO:3002926 vanR gene in vanG cluster Also known as vanRG, is a vanR variant found in the vanG gene cluster. PMID:16723588 vanR_in_vanG_cl Also known as vanRL, is a vanR variant found in the vanL gene cluster. vanR-L vanRL vanR_in_vanL_cl antibiotic_resistance ARO:3002927 vanR gene in vanL cluster Also known as vanRL, is a vanR variant found in the vanL gene cluster. PMID:18458129 vanR_in_vanL_cl Also known as vanRM, is a vanR variant found in the vanM gene cluster. vanR-M vanRM vanR_in_vanM_cl antibiotic_resistance ARO:3002928 vanR gene in vanM cluster Also known as vanRM, is a vanR variant found in the vanM gene cluster. PMID:20733041 vanR_in_vanM_cl Also known as vanRN, is a vanR variant found in the vanN gene cluster. vanR-N vanRN vanR_in_vanN_cl antibiotic_resistance ARO:3002929 vanR gene in vanN cluster Also known as vanRN, is a vanR variant found in the vanN gene cluster. PMID:21807981 vanR_in_vanN_cl Also known as vanRO, is a vanR variant found in the vanO gene cluster. vanR-O vanRO vanR_in_vanO_cl antibiotic_resistance ARO:3002930 vanR gene in vanO cluster Also known as vanRO, is a vanR variant found in the vanO gene cluster. PMID:24342631 vanR_in_vanO_cl Also known as vanSA, is a vanS variant found in the vanA gene cluster. vanS-A vanSA vanS_in_vanA_cl antibiotic_resistance ARO:3002931 vanS gene in vanA cluster Also known as vanSA, is a vanS variant found in the vanA gene cluster. PMID:16323116 PMID:28511809 PMID:8380148 vanS_in_vanA_cl Also known as vanSB, is a vanS variant found in the vanB gene cluster. vanS-B vanSB vanS_in_vanB_cl antibiotic_resistance ARO:3002932 vanS gene in vanB cluster Also known as vanSB, is a vanS variant found in the vanB gene cluster. PMID:16323116 PMID:8631706 vanS_in_vanB_cl Also known as vanSC, is a vanS variant found in the vanC gene cluster. vanS-C vanSC vanS_in_vanC_cl antibiotic_resistance ARO:3002933 vanS gene in vanC cluster Also known as vanSC, is a vanS variant found in the vanC gene cluster. PMID:10817725 PMID:16323116 vanS_in_vanC_cl Also known as vanSD, is a mutated vanS variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis. vanS-D vanSD vanS_in_vanD_cl antibiotic_resistance ARO:3002934 vanS gene in vanD cluster Also known as vanSD, is a mutated vanS variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis. PMID:16323116 PMID:19258279 vanS_in_vanD_cl Also known as vanSE, is a vanS variant found in the vanE gene cluster. vanS-E vanSE vanS_in_vanE_cl antibiotic_resistance ARO:3002935 vanS gene in vanE cluster Also known as vanSE, is a vanS variant found in the vanE gene cluster. PMID:12019119 vanS_in_vanE_cl Also known as vanSF, is a vanS variant found in the vanF gene cluster. vanS-F vanSF vanS_in_vanF_cl antibiotic_resistance ARO:3002936 vanS gene in vanF cluster Also known as vanSF, is a vanS variant found in the vanF gene cluster. PMID:15980329 vanS_in_vanF_cl Also known as vanSG, is a vanS variant found in the vanG gene cluster. vanS-G vanSG vanS_in_vanG_cl antibiotic_resistance ARO:3002937 vanS gene in vanG cluster Also known as vanSG, is a vanS variant found in the vanG gene cluster. PMID:16723588 vanS_in_vanG_cl Also known as vanSL, is a vanS variant found in the vanL gene cluster. vanS-L vanSL vanS_in_vanL_cl antibiotic_resistance ARO:3002938 vanS gene in vanL cluster Also known as vanSL, is a vanS variant found in the vanL gene cluster. PMID:18458129 vanS_in_vanL_cl Also known as vanSM, is a vanS variant found in the vanM gene cluster. vanS-M vanSM vanS_in_vanM_cl antibiotic_resistance ARO:3002939 vanS gene in vanM cluster Also known as vanSM, is a vanS variant found in the vanM gene cluster. PMID:20733041 vanS_in_vanM_cl Also known as vanSN, is a vanS variant found in the vanN gene cluster. vanS-N vanSN vanS_in_vanN_cl antibiotic_resistance ARO:3002940 vanS gene in vanN cluster Also known as vanSN, is a vanS variant found in the vanN gene cluster. PMID:21807981 vanS_in_vanN_cl Also known as vanSO, is a vanS variant found in the vanO gene cluster. vanS-O vanSO vanS_in_vanO_cl antibiotic_resistance ARO:3002941 vanS gene in vanO cluster Also known as vanSO, is a vanS variant found in the vanO gene cluster. PMID:24342631 vanS_in_vanO_cl Also known as vanHA, is a vanH variant in the vanA gene cluster. vanH-A vanHA vanH_in_vanA_cl antibiotic_resistance ARO:3002942 vanH gene in vanA cluster Also known as vanHA, is a vanH variant in the vanA gene cluster. PMID:16323116 PMID:8380148 vanH_in_vanA_cl Also known as vanHB, is a vanH variant in the vanB gene cluster. vanH-B vanHB vanH_in_vanB_cl antibiotic_resistance ARO:3002943 vanH gene in vanB cluster Also known as vanHB, is a vanH variant in the vanB gene cluster. PMID:16323116 PMID:8631706 vanH_in_vanB_cl Also known as vanHD, is a vanH variant in the vanD gene cluster. vanH-D vanHD vanH_in_vanD_cl antibiotic_resistance ARO:3002944 vanH gene in vanD cluster Also known as vanHD, is a vanH variant in the vanD gene cluster. PMID:12499162 PMID:16323116 vanH_in_vanD_cl Also known as vanHF, is a vanH variant in the vanF gene cluster. vanH-F vanHF vanH_in_vanF_cl antibiotic_resistance ARO:3002945 vanH gene in vanF cluster Also known as vanHF, is a vanH variant in the vanF gene cluster. PMID:15980329 vanH_in_vanF_cl Also known as vanHM, is a vanH variant in the vanM gene cluster. vanH-M vanHM vanH_in_vanM_cl antibiotic_resistance ARO:3002947 vanH gene in vanM cluster Also known as vanHM, is a vanH variant in the vanM gene cluster. PMID:20733041 vanH_in_vanM_cl Also known as vanHO, is a vanH variant in the vanO gene cluster. vanH-O vanHO vanH_in_vanO_cl antibiotic_resistance ARO:3002948 vanH gene in vanO cluster Also known as vanHO, is a vanH variant in the vanO gene cluster. PMID:24342631 vanH_in_vanO_cl Also known as vanXA, is a vanX variant found in the vanA gene cluster. vanX-A vanXA vanX_in_vanA_cl antibiotic_resistance ARO:3002949 vanX gene in vanA cluster Also known as vanXA, is a vanX variant found in the vanA gene cluster. PMID:16323116 PMID:8380148 vanX_in_vanA_cl Also known as vanXB, is a vanX variant found in the vanB gene cluster. vanX-B vanXB vanX_in_vanB_cl antibiotic_resistance ARO:3002950 vanX gene in vanB cluster Also known as vanXB, is a vanX variant found in the vanB gene cluster. PMID:16323116 PMID:8631706 vanX_in_vanB_cl Also known as vanXF, is a vanX variant found in the vanF gene cluster. vanX-F vanXF vanX_in_vanF_cl antibiotic_resistance ARO:3002952 vanX gene in vanF cluster Also known as vanXF, is a vanX variant found in the vanF gene cluster. PMID:15980329 vanX_in_vanF_cl Also known as vanXM, is a vanX variant found in the vanM gene cluster. vanX-M vanXM vanX_in_vanM_cl antibiotic_resistance ARO:3002953 vanX gene in vanM cluster Also known as vanXM, is a vanX variant found in the vanM gene cluster. PMID:20733041 vanX_in_vanM_cl Also known as vanXO, is a vanX variant found in the vanO gene cluster. vanX-O vanXO vanX_in_vanO_cl antibiotic_resistance ARO:3002954 vanX gene in vanO cluster Also known as vanXO, is a vanX variant found in the vanO gene cluster. PMID:24342631 vanX_in_vanO_cl Also known as vanYA, is a vanY variant found in the vanA gene cluster. vanY-A vanYA vanY_in_vanA_cl antibiotic_resistance ARO:3002955 vanY gene in vanA cluster Also known as vanYA, is a vanY variant found in the vanA gene cluster. PMID:16323116 PMID:8380148 vanY_in_vanA_cl Also known as vanYB, is a vanY variant found in the vanB gene cluster. vanY-B vanYB vanY_in_vanB_cl antibiotic_resistance ARO:3002956 vanY gene in vanB cluster Also known as vanYB, is a vanY variant found in the vanB gene cluster. PMID:16323116 PMID:8631706 vanY_in_vanB_cl Also known as vanYD, is a vanY variant found in the vanD gene cluster. vanY-D vanYD vanY_in_vanD_cl antibiotic_resistance ARO:3002957 vanY gene in vanD cluster Also known as vanYD, is a vanY variant found in the vanD gene cluster. PMID:12499162 PMID:16323116 vanY_in_vanD_cl Also known as vanYF, is a vanY variant found in the vanF gene cluster. vanY-F vanYF vanY_in_vanF_cl antibiotic_resistance ARO:3002958 vanY gene in vanF cluster Also known as vanYF, is a vanY variant found in the vanF gene cluster. PMID:15980329 vanY_in_vanF_cl Also known as vanYG, is a vanY variant found in the vanG gene cluster. vanY-G vanYG vanYG1 vanY_in_vanG_cl antibiotic_resistance ARO:3002959 vanY gene in vanG cluster Also known as vanYG, is a vanY variant found in the vanG gene cluster. PMID:16723588 vanY_in_vanG_cl Also known as vanYM, is a vanY variant found in the vanM gene cluster. vanY-M vanYM vanY_in_vanM_cl antibiotic_resistance ARO:3002961 vanY gene in vanM cluster Also known as vanYM, is a vanY variant found in the vanM gene cluster. PMID:20733041 vanY_in_vanM_cl Also known as vanZA, is a vanZ variant found in the vanA gene cluster. vanZ-A vanZA vanZ_in_vanA_cl antibiotic_resistance ARO:3002962 vanZ gene in vanA cluster Also known as vanZA, is a vanZ variant found in the vanA gene cluster. PMID:16323116 PMID:7867956 PMID:8380148 vanZ_in_vanA_cl Also known as vanZF, is a vanZ variant found in the vanF gene cluster. vanZ-F vanZF vanZ_in_vanF_cl antibiotic_resistance ARO:3002963 vanZ gene in vanF cluster Also known as vanZF, is a vanZ variant found in the vanF gene cluster. PMID:15980329 vanZ_in_vanF_cl Also known as vanWB, is a vanW variant found in the vanB gene cluster. vanW-B vanWB vanW_in_vanB_cl antibiotic_resistance ARO:3002964 vanW gene in vanB cluster Also known as vanWB, is a vanW variant found in the vanB gene cluster. PMID:16323116 PMID:8631706 vanW_in_vanB_cl Also known as vanWG, is a vanW variant found in the vanG gene cluster. vanW-G vanWG vanW_in_vanG_cl antibiotic_resistance ARO:3002965 vanW gene in vanG cluster Also known as vanWG, is a vanW variant found in the vanG gene cluster. PMID:16723588 vanW_in_vanG_cl Also known as vanXYC, is a vanXY variant found in the vanC gene cluster. vanXY-C vanXYC vanXY_in_vanC antibiotic_resistance ARO:3002966 vanXY gene in vanC cluster Also known as vanXYC, is a vanXY variant found in the vanC gene cluster. PMID:10564477 PMID:16323116 vanXY_in_vanC Also known as vanXY, is a vanXY variant found in the vanE gene cluster. vanXY-E vanXYE vanXY_in_vanE antibiotic_resistance ARO:3002967 vanXY gene in vanE cluster Also known as vanXY, is a vanXY variant found in the vanE gene cluster. PMID:12019119 vanXY_in_vanE Also known as vanXYL, is a vanXY variant found in the vanL gene cluster. vanXY-L vanXYL vanXY_in_vanL antibiotic_resistance ARO:3002968 vanXY gene in vanL cluster Also known as vanXYL, is a vanXY variant found in the vanL gene cluster. PMID:18458129 vanXY_in_vanL Also known as vanXYN, is a vanXY variant found in the vanN gene cluster. vanXY-N vanXYN vanXY_in_vanN antibiotic_resistance ARO:3002969 vanXY gene in vanN cluster Also known as vanXYN, is a vanXY variant found in the vanN gene cluster. PMID:21807981 vanXY_in_vanN Also known as vanTC, is a vanT variant found in the vanC gene cluster. vanT-C vanTC vanT_in_vanC_cl antibiotic_resistance ARO:3002970 vanT gene in vanC cluster Also known as vanTC, is a vanT variant found in the vanC gene cluster. PMID:10209740 PMID:16323116 vanT_in_vanC_cl Also known as vanTE, is a vanT variant found in the vanE gene cluster. vanT-E vanTE vanT_in_vanE_cl antibiotic_resistance ARO:3002971 vanT gene in vanE cluster Also known as vanTE, is a vanT variant found in the vanE gene cluster. PMID:12019119 vanT_in_vanE_cl Also known as vanTG, is a vanT variant found in the vanG gene cluster. vanT-G vanTG vanT_in_vanG_cl antibiotic_resistance ARO:3002972 vanT gene in vanG cluster Also known as vanTG, is a vanT variant found in the vanG gene cluster. PMID:16723588 vanT_in_vanG_cl Also known as vanTmL, is a vanT variant found in the vanL gene cluster. vanTmL codes for the membrane-binding domain of vanTL. vanTm-L vanTmL vanTm_in_vanL antibiotic_resistance ARO:3002973 vanTm gene in vanL cluster Also known as vanTmL, is a vanT variant found in the vanL gene cluster. vanTmL codes for the membrane-binding domain of vanTL. PMID:18458129 vanTm_in_vanL Also known as vanTrL, is a vanT variant found in the vanL gene cluster. vanTrL codes for the racemase component of vanT. vanTr-L vanTrL vanTr_in_vanL antibiotic_resistance ARO:3002974 vanTr gene in vanL cluster Also known as vanTrL, is a vanT variant found in the vanL gene cluster. vanTrL codes for the racemase component of vanT. PMID:18458129 vanTr_in_vanL Also known as vanTN, is a vanT variant found in the vanN gene cluster. vanT-N vanTN vanT_in_vanN_cl antibiotic_resistance ARO:3002975 vanT gene in vanN cluster Also known as vanTN, is a vanT variant found in the vanN gene cluster. PMID:21807981 vanT_in_vanN_cl Van genes encode for various proteins that are involved in conferring vancomycin and teicoplanin resistance. antibiotic_resistance ARO:3002976 gene(s) or protein(s) associated with a glycopeptide resistance cluster A van ligase that synthesizes D-Ala-D-Lac, an alternative peptidoglycan substrate that confers resistance to vancomycin. antibiotic_resistance ARO:3002978 D-Ala-D-Lac ligase A van ligase that synthesizes D-Ala-D-Lac, an alternative peptidoglycan substrate that confers resistance to vancomycin. PMID:15980329 PMID:16323116 PMID:20733041 PMID:24342631 A van ligase that synthesizes D-Ala-D-Ser, an alternative peptidoglycan substrate that confers resistance to vancomycin. antibiotic_resistance ARO:3002979 D-Ala-D-Ser ligase A van ligase that synthesizes D-Ala-D-Ser, an alternative peptidoglycan substrate that confers resistance to vancomycin. PMID:12019119 PMID:16323116 PMID:16723588 PMID:18458129 PMID:21807981 PMID:22969085 Aspergillomarasmine A, a fungal natural product, has been shown to inhibit the NDM-1 and VIM-2 enzymes, restoring of the activity of meropenem against carbapenem-resistant pathogens possessing either NDM-1 or VIM-2. pubchem.compound:197028 BRN 2422056 Toxin C antibiotic_resistance ARO:3002980 aspergillomarasmine A Aspergillomarasmine A, a fungal natural product, has been shown to inhibit the NDM-1 and VIM-2 enzymes, restoring of the activity of meropenem against carbapenem-resistant pathogens possessing either NDM-1 or VIM-2. PMID:24965651 PMID:35155911 AmrAB is an RND efflux system that impairs aminoglycoside accumulation in clinical Burkholderia vietnamiensis strains. antibiotic_resistance ARO:3002981 AmrAB-OprM AmrAB is an RND efflux system that impairs aminoglycoside accumulation in clinical Burkholderia vietnamiensis strains. PMID:10582892 PMID:24393536 amrA is the efflux pump subunit of the AmrAB-OprM multidrug efflux complex. amrA corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. amrA antibiotic_resistance ARO:3002982 amrA amrA is the efflux pump subunit of the AmrAB-OprM multidrug efflux complex. amrA corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PMID:10582892 PMID:24393536 amrA amrB is the membrane fusion protein of the AmrAB-OprM multidrug efflux complex. amrB antibiotic_resistance ARO:3002983 amrB amrB is the membrane fusion protein of the AmrAB-OprM multidrug efflux complex. PMID:10582892 PMID:24393536 amrB arnA modifies lipid A with 4-amino-4-deoxy-L-arabinose (Ara4N) which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. arnA is found in E. coli and P. aeruginosa. PmrL arnA antibiotic_resistance ARO:3002985 arnA arnA modifies lipid A with 4-amino-4-deoxy-L-arabinose (Ara4N) which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. arnA is found in E. coli and P. aeruginosa. PMID:11021929 PMID:15939024 arnA The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. bacA antibiotic_resistance ARO:3002986 bacA The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. PMID:23460607 bacA bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance. bcrA antibiotic_resistance ARO:3002987 bcrA bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance. PMID:7476193 bcrA bcrB is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance. bcrB antibiotic_resistance ARO:3002988 bcrB bcrB is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance. PMID:7476193 bcrB AQU beta-lactamases are chromosomal class C beta-lactamases that confer resistance to cephalosporins. antibiotic_resistance ARO:3002992 AQU beta-lactamase AQU beta-lactamases are chromosomal class C beta-lactamases that confer resistance to cephalosporins. PMID:24055254 AQU-1 is a chromosomal class C beta-lactamase found in clinical Aeromonas dhakensis isolates. AQU-1 antibiotic_resistance ARO:3002993 AQU-1 AQU-1 is a chromosomal class C beta-lactamase found in clinical Aeromonas dhakensis isolates. PMID:24055254 AQU-1 ROB beta-lactamases are a class A beta-lactamases. antibiotic_resistance ARO:3002994 ROB beta-lactamase ROB beta-lactamases are a class A beta-lactamases. PMID:2201253 ROB-1 is a beta-lactamase found in Pasteurella and Haemophilus. ROB-1 antibiotic_resistance ARO:3002995 ROB-1 ROB-1 is a beta-lactamase found in Pasteurella and Haemophilus. PMID:17438055 PMID:2024956 ROB-1 LCR beta-lactamases are a class D beta-lactamase that hydrolyze a variety of penams and some cephalosporins. antibiotic_resistance ARO:3002996 LCR beta-lactamase LCR-1 is a class D beta-lactamase found in Pseudomonas aeruginosa. LCR-1 antibiotic_resistance ARO:3002997 LCR-1 LCR-1 is a class D beta-lactamase found in Pseudomonas aeruginosa. PMID:1495394 LCR-1 CblA beta-lactamases are class A beta-lactamases that confer resistance to cephalosporins. antibiotic_resistance ARO:3002998 CblA beta-lactamase CblA beta-lactamases are class A beta-lactamases that confer resistance to cephalosporins. PMID:7985999 CblA-1 beta-lactamase is a class A beta-lactamase found in Bacteroides uniformis that is species-specific. CblA-1 antibiotic_resistance ARO:3002999 CblA-1 CblA-1 beta-lactamase is a class A beta-lactamase found in Bacteroides uniformis that is species-specific. PMID:7985999 CblA-1 CfxA beta-lactamases are class A beta-lactamases. antibiotic_resistance ARO:3003000 CfxA beta-lactamase CfxA beta-lactamases are class A beta-lactamases. PMID:8517690 CfxA beta-lactamase is a class A beta-lactamase found in Bacteroides vulgatus. CfxA antibiotic_resistance ARO:3003001 CfxA CfxA beta-lactamase is a class A beta-lactamase found in Bacteroides vulgatus. PMID:8517690 CfxA CfxA2 beta-lactamase is a class A beta-lactamase found in Prevotella intermedia. CfxA2 antibiotic_resistance ARO:3003002 CfxA2 CfxA2 beta-lactamase is a class A beta-lactamase found in Prevotella intermedia. PMID:11451705 CfxA2 CfxA3 beta-lactamase is a class A beta-lactamase found in Capnocytophaga ochracea. CfxA3 antibiotic_resistance ARO:3003003 CfxA3 CfxA3 beta-lactamase is a class A beta-lactamase found in Capnocytophaga ochracea. PMID:14766881 CfxA3 cfxA4 beta-lactamase is a class A beta-lactamase found in Bacteroides fragilis. CfxA4 antibiotic_resistance ARO:3003005 CfxA4 cfxA4 beta-lactamase is a class A beta-lactamase found in Bacteroides fragilis. PMID:25460195 CfxA4 blt is an MFS efflux pump that confers resistance to multiple drugs such as rhodamine and acridine dyes, and fluoroquinolone antibiotics. blt antibiotic_resistance ARO:3003006 blt blt is an MFS efflux pump that confers resistance to multiple drugs such as rhodamine and acridine dyes, and fluoroquinolone antibiotics. PMID:7608059 blt bmr is an MFS antibiotic efflux pump that confers resistance to multiple drugs including acridine dyes, fluoroquinolone antibiotics, chloramphenicol, and puromycin. bmr antibiotic_resistance ARO:3003007 bmr bmr is an MFS antibiotic efflux pump that confers resistance to multiple drugs including acridine dyes, fluoroquinolone antibiotics, chloramphenicol, and puromycin. PMID:1675788 PMID:9079903 bmr CeoAB is an RND efflux system that confers multidrug resistance in Burkholderia cenocepacia. antibiotic_resistance ARO:3003008 CeoAB-OpcM CeoAB is an RND efflux system that confers multidrug resistance in Burkholderia cenocepacia. PMID:16857052 ceoA is a periplasmic linker subunit of the CeoAB-OpcM efflux pump. ceoA antibiotic_resistance ARO:3003009 ceoA ceoA is a periplasmic linker subunit of the CeoAB-OpcM efflux pump. PMID:16857052 ceoA ceoB is a cytoplasmic membrane component of the CeoAB-OpcM efflux pump. ceoB antibiotic_resistance ARO:3003010 ceoB ceoB is a cytoplasmic membrane component of the CeoAB-OpcM efflux pump. PMID:16857052 ceoB dfrA10 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae. dfrA10 antibiotic_resistance ARO:3003011 dfrA10 dfrA10 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae. PMID:12499211 dfrA10 dfrA13 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA13 antibiotic_resistance ARO:3003012 dfrA13 dfrA13 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:15140390 PMID:20374640 PMID:21237262 dfrA13 dfrA15 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. dfrA15 antibiotic_resistance ARO:3003013 dfrA15 dfrA15 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. PMID:16980697 dfrA15 dfrA16 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. dfrA16 antibiotic_resistance ARO:3003014 dfrA16 dfrA16 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. PMID:17233727 dfrA16 dfrA19 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae. dfrA19 antibiotic_resistance ARO:3003015 dfrA19 dfrA19 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae. PMID:17368003 dfrA19 dfrA20 is a plasmid-encoded dihydrofolate reductase found in Pasteurella multocida. dfrA20 antibiotic_resistance ARO:3003016 dfrA20 dfrA20 is a plasmid-encoded dihydrofolate reductase found in Pasteurella multocida. PMID:15616323 dfrA20 dfrA21 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. dfrA21 antibiotic_resistance ARO:3003017 dfrA21 dfrA21 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. PMID:15750057 dfrA21 dfrA22 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. dfrA22 antibiotic_resistance ARO:3003018 dfrA22 dfrA22 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. PMID:16782743 PMID:24152716 dfrA22 dfrA23 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. dfrA23 antibiotic_resistance ARO:3003019 dfrA23 dfrA23 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. PMID:15728925 dfrA23 dfrA25 is an integron-encoded dihydrofolate reductase found in Salmonella agona. dfrA25 antibiotic_resistance ARO:3003020 dfrA25 dfrA25 is an integron-encoded dihydrofolate reductase found in Salmonella agona. PMID:16980698 dfrA25 dfrB2 is an integron-encoded dihydrofolate reductase found in an uncultured bacterium from a wastewater treatment plant. dfrB2 antibiotic_resistance ARO:3003021 dfrB2 dfrB2 is an integron-encoded dihydrofolate reductase found in an uncultured bacterium from a wastewater treatment plant. PMID:17261525 PMID:19719593 dfrB2 dfrB3 is an integron-encoded dihydrofolate reductase found in Klebsiella oxytoca. dfrB3 antibiotic_resistance ARO:3003022 dfrB3 dfrB3 is an integron-encoded dihydrofolate reductase found in Klebsiella oxytoca. PMID:22507248 dfrB3 dfrB6 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. dfrB6 antibiotic_resistance ARO:3003023 dfrB6 dfrB6 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. PMID:16870788 dfrB6 Enzymes that confer resistance to fusidic acid by inactivation. antibiotic_resistance ARO:3003025 fusidic acid inactivation enzyme fusH is a highly specific fusidic acid esterase found in Streptomyces lividans. fusH antibiotic_resistance ARO:3003026 fusH fusH is a highly specific fusidic acid esterase found in Streptomyces lividans. PMID:9084170 fusH lmrAB operon is involved in lincosamide resistance in Bacillus subtilis. antibiotic_resistance ARO:3003027 lmrAB Operon lmrAB operon is involved in lincosamide resistance in Bacillus subtilis. PMID:15317768 lmrA is the repressor to the lmrAB operon in Bacillus subtilis. lmrA mutations result in lincomycin resistance. lmrA antibiotic_resistance ARO:3003028 lmrA lmrA is the repressor to the lmrAB operon in Bacillus subtilis. lmrA mutations result in lincomycin resistance. PMID:15317768 PMID:9384377 lmrA MexVW-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexV is the membrane fusion protein; MexW is the RND-type membrane protein; and OprM is the outer membrane channel. MexVW-OprM is associated with resistance to fluoroquinolones, tetracycline, chloramphenicol, erythromycin and acriflavine. MexVW-OprM antibiotic_resistance ARO:3003029 MexVW-OprM MexVW-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexV is the membrane fusion protein; MexW is the RND-type membrane protein; and OprM is the outer membrane channel. MexVW-OprM is associated with resistance to fluoroquinolones, tetracycline, chloramphenicol, erythromycin and acriflavine. PMID:12951344 MexVW-OprM MexV is the membrane fusion protein of the MexVW-OprM multidrug efflux complex. MexV antibiotic_resistance ARO:3003030 MexV MexV is the membrane fusion protein of the MexVW-OprM multidrug efflux complex. PMID:12951344 MexV MexW is the RND-type membrane protein of the efflux complex MexVW-OprM. MexW antibiotic_resistance ARO:3003031 MexW MexW is the RND-type membrane protein of the efflux complex MexVW-OprM. PMID:12951344 MexW MexXY-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprM is the outer membrane channel. MexXY-OprM is associated with resistance to acriflavine, erythromycin, norfloxacin and ofloxacin. The efflux system may also be involved in acquisition of higher resistance, in particular when bacteria are repeatedly exposed to subinhibitory doses of AGs. MexXY-OprM antibiotic_resistance ARO:3003032 MexXY-OprM MexXY-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprM is the outer membrane channel. MexXY-OprM is associated with resistance to acriflavine, erythromycin, norfloxacin and ofloxacin. The efflux system may also be involved in acquisition of higher resistance, in particular when bacteria are repeatedly exposed to subinhibitory doses of AGs. PMID:12654672 PMID:9925549 MexXY-OprM MexY is the RND-type membrane protein of the efflux complex MexXY-OprM. mexY antibiotic_resistance ARO:3003033 mexY MexY is the RND-type membrane protein of the efflux complex MexXY-OprM. PMID:9925549 mexY MexX is the membrane fusion protein of the MexXY-OprM multidrug efflux complex. mexX antibiotic_resistance ARO:3003034 mexX MexX is the membrane fusion protein of the MexXY-OprM multidrug efflux complex. PMID:9925549 mexX mfpA is a qnr homolog and a pentapeptide repeat protein that confers resistance to fluoroquinolones in Mycolicibacterium smegmatis. PDB:2BM7 mfpA antibiotic_resistance ARO:3003035 mfpA mfpA is a qnr homolog and a pentapeptide repeat protein that confers resistance to fluoroquinolones in Mycolicibacterium smegmatis. PMID:15933203 mfpA oleB is an ABC-F subfamily protein in Streptomyces antibioticus and is involved in oleandomycin secretion. oleB antibiotic_resistance ARO:3003036 oleB oleB is an ABC-F subfamily protein in Streptomyces antibioticus and is involved in oleandomycin secretion. PMID:9003412 oleB OpcM is an outer membrane factor protein found in Burkholderia cepacia. It is part of the CeoAB-OpcM complex. opcM antibiotic_resistance ARO:3003037 opcM OpcM is an outer membrane factor protein found in Burkholderia cepacia. It is part of the CeoAB-OpcM complex. PMID:8834871 opcM MexXY-OprA is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprA is the outer membrane channel. MexXY-OprA is associated with resistance to aminoglycosides. MexXY-OprA antibiotic_resistance ARO:3003038 MexXY-OprA MexXY-OprA is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprA is the outer membrane channel. MexXY-OprA is associated with resistance to aminoglycosides. PMID:22282519 MexXY-OprA OprA is an outer membrane factor protein found in Pseudomonas aeruginosa. It is part of the MexXY-OprA complex. OprA antibiotic_resistance ARO:3003039 OprA OprA is an outer membrane factor protein found in Pseudomonas aeruginosa. It is part of the MexXY-OprA complex. PMID:22282519 OprA Pencillin-binding proteins are transpeptidase proteins essential for cell wall synthesis. PBPs bind to penicillin antibiotics, which inactivates the enzyme and therefore disrupts cell wall synthesis. Multiple mechanisms and determinants are implicated in antibiotic resistant PBP. antibiotic_resistance ARO:3003040 beta-lactam resistant penicillin-binding proteins PBP1a is a penicillin-binding protein found in Streptococcus pneumoniae. Spne_PBP1a_AMX antibiotic_resistance ARO:3003041 Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin PBP1a is a penicillin-binding protein found in Streptococcus pneumoniae. PMID:18394970 Spne_PBP1a_AMX PBP2b is a penicillin-binding protein found in Streptococcus pneumoniae. Spne_PBP2b_AMX antibiotic_resistance ARO:3003042 Streptococcus pneumoniae PBP2b conferring resistance to amoxicillin PBP2b is a penicillin-binding protein found in Streptococcus pneumoniae. PMID:18394970 Spne_PBP2b_AMX PBP2x is a penicillin-binding protein found in Streptococcus pneumoniae. Spne_PBP2x_AMX antibiotic_resistance ARO:3003043 Streptococcus pneumoniae PBP2x conferring resistance to amoxicillin PBP2x is a penicillin-binding protein found in Streptococcus pneumoniae. PMID:18394970 Spne_PBP2x_AMX qacA is a subunit of the qac multidrug efflux pump. qacA antibiotic_resistance ARO:3003046 qacA qacA is a subunit of the qac multidrug efflux pump. PMID:12820795 qacA qacB is a subunit of the qac multidrug efflux pump. qacB antibiotic_resistance ARO:3003047 qacB qacB is a subunit of the qac multidrug efflux pump. PMID:12820795 qacB rosA is part of an efflux pump/potassium antiporter system (RosAB) in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B. rosA antibiotic_resistance ARO:3003048 rosA rosA is part of an efflux pump/potassium antiporter system (RosAB) in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B. PMID:10931306 rosA rosB is part of an efflux pump/potassium antiporter system (RosAB) in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B. rosB antibiotic_resistance ARO:3003049 rosB rosB is part of an efflux pump/potassium antiporter system (RosAB) in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B. PMID:10931306 rosB SmeABC is a multidrug resistance efflux pump that confers resistance to aminoglycosides, beta-lactams, and fluoroquinolones in Stenotrophomonas maltophilia. antibiotic_resistance ARO:3003050 SmeABC SmeABC is a multidrug resistance efflux pump that confers resistance to aminoglycosides, beta-lactams, and fluoroquinolones in Stenotrophomonas maltophilia. PMID:11796339 smeA is the membrane fusion protein of the smeABC multidrug efflux complex in Stenotrophomonas maltophilia. smeA antibiotic_resistance ARO:3003051 smeA smeA is the membrane fusion protein of the smeABC multidrug efflux complex in Stenotrophomonas maltophilia. PMID:11796339 smeA smeB is the inner membrane multidrug exporter of the efflux complex smeABC in Stenotrophomonas maltophilia. smeB antibiotic_resistance ARO:3003052 smeB smeB is the inner membrane multidrug exporter of the efflux complex smeABC in Stenotrophomonas maltophilia. PMID:11796339 smeB smeC is an outer membrane multidrug efflux protein of the smeABC complex in Stenotrophomonas maltophilia. smeC antibiotic_resistance ARO:3003053 smeC smeC is an outer membrane multidrug efflux protein of the smeABC complex in Stenotrophomonas maltophilia. PMID:11796339 smeC SmeDEF is a multidrug resistance efflux pump that confers resistance to quinolones, tetracyclines, macrolides, chloramphenicol, and novobiocin in Stenotrophomonas maltophilia. antibiotic_resistance ARO:3003054 SmeDEF SmeDEF is a multidrug resistance efflux pump that confers resistance to quinolones, tetracyclines, macrolides, chloramphenicol, and novobiocin in Stenotrophomonas maltophilia. PMID:11709330 smeD is the membrane fusion protein of the smeDEF multidrug efflux complex in Stenotrophomonas maltophilia. smeD antibiotic_resistance ARO:3003055 smeD smeD is the membrane fusion protein of the smeDEF multidrug efflux complex in Stenotrophomonas maltophilia. PMID:11709330 smeD smeE is the RND protein of the efflux complex smeDEF in Stenotrophomonas maltophilia. smeE antibiotic_resistance ARO:3003056 smeE smeE is the RND protein of the efflux complex smeDEF in Stenotrophomonas maltophilia. PMID:11709330 smeE smeF is an outer membrane multidrug efflux protein of the smeDEF complex in Stenotrophomonas maltophilia. smeF antibiotic_resistance ARO:3003057 smeF smeF is an outer membrane multidrug efflux protein of the smeDEF complex in Stenotrophomonas maltophilia. PMID:11709330 smeF tmrB is an ATP-binding tunicamycin resistance protein found in Bacillus subtilis. tmrB antibiotic_resistance ARO:3003059 tmrB tmrB is an ATP-binding tunicamycin resistance protein found in Bacillus subtilis. PMID:7766032 tmrB tsnR is a 23S ribosomal RNA methyltransferase that methylates adenosine-1067 to confer resistance to thiostrepton. tsnR antibiotic_resistance ARO:3003060 tsnR tsnR is a 23S ribosomal RNA methyltransferase that methylates adenosine-1067 to confer resistance to thiostrepton. PMID:7590303 tsnR vph is a phosphotransferase that confers resistance to viomycin in Streptomyces vinaceus. vph antibiotic_resistance ARO:3003061 vph vph is a phosphotransferase that confers resistance to viomycin in Streptomyces vinaceus. PMID:2987648 vph ykkCD is a multidrug efflux pump with two SMR-type protein subunits that confers resistance to cationic drugs, chloramphenicol, streptomycin and tetracycline. antibiotic_resistance ARO:3003062 ykkCD ykkCD is a multidrug efflux pump with two SMR-type protein subunits that confers resistance to cationic drugs, chloramphenicol, streptomycin and tetracycline. PMID:10735877 ykkC is an SMR-type protein that is a subunit of the ykkCD efflux pump. ykkC antibiotic_resistance ARO:3003063 ykkC ykkC is an SMR-type protein that is a subunit of the ykkCD efflux pump. PMID:10735877 ykkC ykkD is an SMR-type protein that is a subunit of the ykkCD efflux pump. ykkD antibiotic_resistance ARO:3003064 ykkD ykkD is an SMR-type protein that is a subunit of the ykkCD efflux pump. PMID:10735877 ykkD Non-erm 23S ribosomal RNA methyltransferases modify adenosine 1067 to confer resistance to peptide antibiotics. antibiotic_resistance ARO:3003065 non-erm 23S ribosomal RNA methyltransferase (A1067) smeR is the responder component of a two component signal transduction system that includes smeS. smeR antibiotic_resistance ARO:3003066 smeR smeR is the responder component of a two component signal transduction system that includes smeS. PMID:11796339 smeR smeS is the protein kinase sensor component of a two component signal transduction system that includes smeR. smeS antibiotic_resistance ARO:3003067 smeS smeS is the protein kinase sensor component of a two component signal transduction system that includes smeR. PMID:11796339 smeS smeRS is a two component regulatory system for smeABC where smeR is a response regulator, while smeS is a sensor kinase. antibiotic_resistance ARO:3003068 smeRS Also known as vanXYG, is a vanXY variant found in the vanG gene cluster. vanXY-G vanXYG vanXY_in_vanG vanYG2 antibiotic_resistance ARO:3003069 vanXY gene in vanG cluster Also known as vanXYG, is a vanXY variant found in the vanG gene cluster. PMID:16723588 vanXY_in_vanG Also known as vanXD, is a vanX variant found in the vanD gene cluster. vanX-D vanXD vanX_in_vanD_cl antibiotic_resistance ARO:3003070 vanX gene in vanD cluster Also known as vanXD, is a vanX variant found in the vanD gene cluster. PMID:12499162 vanX_in_vanD_cl mphF is a macrolide phosphotransferase and resistance gene identified on the IncP plasmid pRSB111. mphF antibiotic_resistance ARO:3003071 mphF mphF is a macrolide phosphotransferase and resistance gene identified on the IncP plasmid pRSB111. PMID:17101677 PMID:29317655 mphF mphL is a chromosomally-encoded macrolide phosphotransferases that inactivate 14- and 15-membered macrolides such as erythromycin, clarithromycin, azithromycin. mphL antibiotic_resistance ARO:3003072 mphL mphL is a chromosomally-encoded macrolide phosphotransferases that inactivate 14- and 15-membered macrolides such as erythromycin, clarithromycin, azithromycin. PMID:25059531 PMID:29317655 mphL Cardiolipin synthetase (cls) is an inner membrane protein that is involved in membrane synthesis. Specific mutations in S. aureus can confer resistance to daptomycin. Saur_cls_DAP cls1 cls2 antibiotic_resistance ARO:3003074 Staphylococcus aureus cls conferring resistance to daptomycin Cardiolipin synthetase (cls) is an inner membrane protein that is involved in membrane synthesis. Specific mutations in S. aureus can confer resistance to daptomycin. PMID:22238576 Saur_cls_DAP liaFSR is a two-component signal transduction pathway in B. subtilis that responds to peptide and lipopeptide antibiotics. The liaFSR two-component system consists of a histidine kinase liaS and the response regulator liaR as well as the accessory protein liaF, which acts as a negative regulator of liaRS-dependent signal transduction. Mutations confer resistance to daptomycin. antibiotic_resistance ARO:3003076 daptomycin resistant liaFSR liaFSR is a two-component signal transduction pathway in B. subtilis that responds to peptide and lipopeptide antibiotics. The liaFSR two-component system consists of a histidine kinase liaS and the response regulator liaR as well as the accessory protein liaF, which acts as a negative regulator of liaRS-dependent signal transduction. Mutations confer resistance to daptomycin. PMID:21899450 liaF is an accessory protein that acts as a negative regulator of liaRS signal transduction pathway. Mutations confer daptomycin resistance. Efae_liaF_DAP antibiotic_resistance ARO:3003077 Enterococcus faecalis liaF mutant conferring daptomycin resistance liaF is an accessory protein that acts as a negative regulator of liaRS signal transduction pathway. Mutations confer daptomycin resistance. PMID:21899450 PMID:23959318 Efae_liaF_DAP liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. Efac_liaR_DAP yvqE antibiotic_resistance ARO:3003078 Enterococcus faecium liaR mutant conferring daptomycin resistance liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. PMID:21899450 Efac_liaR_DAP liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. Efac_liaS_DAP yvqC antibiotic_resistance ARO:3003079 Enterococcus faecium liaS mutant conferring daptomycin resistance liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. PMID:21899450 PMID:22664970 Efac_liaS_DAP pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. It is a CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase. Laboratory experiments have detected mutations conferring daptomycin resistance in Entercoccus. phosphatidylglycerophosphate synthetase antibiotic_resistance ARO:3003080 daptomycin resistant pgsA pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. It is a CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase. Laboratory experiments have detected mutations conferring daptomycin resistance in Entercoccus. PMID:21709092 PMID:22238576 Daptomycin resistant RNA polymerases include amino acids substitutions which alter expression of the dlt operon, which increases the cell surface positive charge. Known from S. aureus. antibiotic_resistance ARO:3003090 daptomycin resistant beta-subunit of RNA polymerase (rpoB) Daptomycin resistant RNA polymerases include amino acids substitutions which alter expression of the dlt operon, which increases the cell surface positive charge. Known from S. aureus. PMID:20837752 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Mutations in mprF can additionally confer resistance to daptomycin in S. aureus. antibiotic_resistance ARO:3003091 daptomycin resistant mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Mutations in mprF can additionally confer resistance to daptomycin in S. aureus. PMID:16723576 PMID:20498310 PMID:22238576 cls or cardiolipin synthetase is an inner membrane protein that is involved in membrane synthesis. Specific mutations in Enterococcus can confer resistance to daptomycin. Efac_cls_DAP cls1 cls2 antibiotic_resistance ARO:3003092 Enterococcus faecium cls conferring resistance to daptomycin cls or cardiolipin synthetase is an inner membrane protein that is involved in membrane synthesis. Specific mutations in Enterococcus can confer resistance to daptomycin. PMID:21899450 PMID:22948885 PMID:23114777 PMID:23580562 PMID:26454536 Efac_cls_DAP CEPH-A3 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas veronii. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. cphA3 antibiotic_resistance ARO:3003093 cphA3 cphA3 imiH is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophila. This enzyme has specific activity against carbapenems. imiH antibiotic_resistance ARO:3003094 imiH imiH is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophila. This enzyme has specific activity against carbapenems. PMID:12746371 imiH imiS is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas veronii. This enzyme has specific activity against carbapenems. imiS antibiotic_resistance ARO:3003095 imiS imiS is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas veronii. This enzyme has specific activity against carbapenems. PMID:9527802 imiS CfxA5 beta-lactamase is a class A beta-lactamase found in Bacteroides distasonis. CfxA5 antibiotic_resistance ARO:3003096 CfxA5 CfxA5 beta-lactamase is a class A beta-lactamase found in Bacteroides distasonis. PMID:24606061 CfxA5 CfxA6 beta-lactamase is a class A beta-lactamase found in an uncultured bacterium. CfxA6 antibiotic_resistance ARO:3003097 CfxA6 CfxA6 beta-lactamase is a class A beta-lactamase found in an uncultured bacterium. PMID:19713526 CfxA6 CphA2 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophila. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. PDB:2QDS cphA2 antibiotic_resistance ARO:3003099 cphA2 CphA2 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophila. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. PMID:22009263 PMID:9021171 cphA2 CphA4 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas allosaccharophila. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. cphA4 antibiotic_resistance ARO:3003100 cphA4 cphA4 cphA5 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas salmonicida. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. cphA5 antibiotic_resistance ARO:3003101 cphA5 cphA5 cphA6 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas veronii. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. cphA6 antibiotic_resistance ARO:3003102 cphA6 cphA6 cphA7 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas jandaei. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. cphA7 antibiotic_resistance ARO:3003103 cphA7 cphA7 cphA8 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas sobria. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. cphA8 antibiotic_resistance ARO:3003104 cphA8 cphA8 dfrA3 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA3 antibiotic_resistance ARO:3003105 dfrA3 dfrA3 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:20169085 dfrA3 Erm42 confers MLSb phenotype in Pasteurella multocida. Erm(42) Erm42 antibiotic_resistance ARO:3003106 Erm(42) Erm42 confers MLSb phenotype in Pasteurella multocida. PMID:21402855 Erm(42) mef(B) is a macrolide efflux gene located in the vicinity of sul3 in Escherichia coli. There is also a mefB found in Streptococcus agalactiae that confers resistance to macrolides. mef(B) mefB antibiotic_resistance ARO:3003107 mef(B) mef(B) is a macrolide efflux gene located in the vicinity of sul3 in Escherichia coli. There is also a mefB found in Streptococcus agalactiae that confers resistance to macrolides. PMID:19131424 PMID:27052334 mef(B) MsrE is an ABC-F subfamily protein expressed to Klebsiella pneumoniae that confers resistance to erythromycin and streptogramin B antibiotics. It is associated with plasmid DNA. It is also 100% identical to ABC-F type ribosomal protection protein Msr(E) which is in multiple species. msr(E) msrE antibiotic_resistance ARO:3003109 msrE MsrE is an ABC-F subfamily protein expressed to Klebsiella pneumoniae that confers resistance to erythromycin and streptogramin B antibiotics. It is associated with plasmid DNA. It is also 100% identical to ABC-F type ribosomal protection protein Msr(E) which is in multiple species. PMID:23114767 msrE catB10 is an integron-encoded variant of the cat gene found in P. aeruginosa. catB10 antibiotic_resistance ARO:3003110 catB10 catB10 is an integron-encoded variant of the cat gene found in P. aeruginosa. PMID:20735174 catB10 LsaB is an ABC-F subfamily protein expressed in Mammaliicoccus sciuri. It confers resistance to clindamycin. lsaB antibiotic_resistance ARO:3003111 lsaB LsaB is an ABC-F subfamily protein expressed in Mammaliicoccus sciuri. It confers resistance to clindamycin. PMID:15471995 PMID:21245447 lsaB LsaC is an ABC-F subfamily protein expressed in Streptococcus agalactiae. It confers resistance to lincomycin, clindamycin, dalfopristin, and tiamulin. lsaC antibiotic_resistance ARO:3003112 lsaC LsaC is an ABC-F subfamily protein expressed in Streptococcus agalactiae. It confers resistance to lincomycin, clindamycin, dalfopristin, and tiamulin. PMID:21245447 lsaC From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3003113 TEM-221 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3003114 TEM-222 From the Lahey list of beta-lactamases. Not yet released. OXA-427 antibiotic_resistance ARO:3003115 OXA-427 OXA-427 From the Lahey list of beta-lactamases. Not yet released. OXA-420 antibiotic_resistance ARO:3003116 OXA-420 OXA-420 From the Lahey list of beta-lactamases. Not yet released. OXA-421 antibiotic_resistance ARO:3003117 OXA-421 OXA-421 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3003119 OXA-428 From the Lahey list of beta-lactamases. Not yet released. OXA-429 antibiotic_resistance ARO:3003120 OXA-429 OXA-429 From the Lahey list of beta-lactamases. Not yet released. OXA-430 antibiotic_resistance ARO:3003121 OXA-430 OXA-430 From the Lahey list of beta-lactamases. Not yet released. OXA-431 antibiotic_resistance ARO:3003124 OXA-431 OXA-431 From the Lahey list of beta-lactamases. Not yet released. OXA-432 antibiotic_resistance ARO:3003125 OXA-432 OXA-432 From the Lahey list of beta-lactamases. Not yet released. OXA-433 antibiotic_resistance ARO:3003126 OXA-433 OXA-433 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3003127 OXA-434 An OXA-48-like plasmid-encoded beta-lactamase shown to confer resistance to carbapenems through hydrolysis. Identified in multiple Enterobacteriaceae isolates from several patients in Denmark. Beta-lactamase activity against carbapenems and penicillins but little to no activity against cephalosporin antibiotics. Described by Samuelsen et al. 2017. OXA-436 antibiotic_resistance ARO:3003128 OXA-436 An OXA-48-like plasmid-encoded beta-lactamase shown to confer resistance to carbapenems through hydrolysis. Identified in multiple Enterobacteriaceae isolates from several patients in Denmark. Beta-lactamase activity against carbapenems and penicillins but little to no activity against cephalosporin antibiotics. Described by Samuelsen et al. 2017. PMID:29061750 OXA-436 CMY-121 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 09-SEP-2014. CMY-121 antibiotic_resistance ARO:3003129 CMY-121 CMY-121 CMY-122 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-MAY-2016. CMY-122 antibiotic_resistance ARO:3003130 CMY-122 CMY-122 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3003131 CMY-123 CMY-124 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016. CMY-124 antibiotic_resistance ARO:3003132 CMY-124 CMY-124 CMY-125 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-MAY-2016. CMY-125 antibiotic_resistance ARO:3003133 CMY-125 CMY-125 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3003134 CMY-126 CMY-127 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 18-OCT-2014. CMY-127 antibiotic_resistance ARO:3003135 CMY-127 CMY-127 CMY-128 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 18-OCT-2014. CMY-128 antibiotic_resistance ARO:3003136 CMY-128 CMY-128 CMY-129 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 18-OCT-2014. CMY-129 antibiotic_resistance ARO:3003137 CMY-129 CMY-129 CMY-130 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-130 antibiotic_resistance ARO:3003138 CMY-130 CMY-130 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. PMID:26048440 CMY-130 From the Lahey list of beta-lactamases. Not yet released. MIR-18 antibiotic_resistance ARO:3003139 MIR-18 MIR-18 From the Lahey list of beta-lactamases. Not yet released. MOX-10 antibiotic_resistance ARO:3003140 MOX-10 MOX-10 From the Lahey list of beta-lactamases. Not yet released. MOX-11 antibiotic_resistance ARO:3003141 MOX-11 MOX-11 From the Lahey list of beta-lactamases. Not yet released. IMI-8 antibiotic_resistance ARO:3003142 IMI-8 IMI-8 From the Lahey list of beta-lactamases. Not yet released. IMI-9 antibiotic_resistance ARO:3003143 IMI-9 IMI-9 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3003144 KPC-20 From the Lahey list of beta-lactamases. Not yet released. KPC-21 antibiotic_resistance ARO:3003145 KPC-21 KPC-21 From the Lahey list of beta-lactamases. Not yet released. VEB-10 antibiotic_resistance ARO:3003146 VEB-10 VEB-10 OXA-424 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii found in China. It is carbapenem resistant. OXA-424 antibiotic_resistance ARO:3003147 OXA-424 OXA-424 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii found in China. It is carbapenem resistant. PMID:25487793 OXA-424 OXA-425 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem-resistant. OXA-425 antibiotic_resistance ARO:3003148 OXA-425 OXA-425 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem-resistant. PMID:25487793 OXA-425 OXA-426 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem resistant. OXA-426 antibiotic_resistance ARO:3003149 OXA-426 OXA-426 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem resistant. PMID:25487793 OXA-426 CARB-20 is a beta-lactamase found worldwide in Vibrio parahaemolyticus. CARB-20 antibiotic_resistance ARO:3003150 CARB-20 CARB-20 is a beta-lactamase found worldwide in Vibrio parahaemolyticus. PMID:23469330 CARB-20 From the Lahey list of beta-lactamases. CARB-22 antibiotic_resistance ARO:3003151 CARB-22 CARB-22 From the Lahey list of beta-lactamases. SHV-185 antibiotic_resistance ARO:3003152 SHV-185 SHV-185 From the Lahey list of beta-lactamases. SHV-186 antibiotic_resistance ARO:3003153 SHV-186 SHV-186 From the Lahey list of beta-lactamases. SHV-187 antibiotic_resistance ARO:3003154 SHV-187 SHV-187 From the Lahey list of beta-lactamases. SHV-188 antibiotic_resistance ARO:3003155 SHV-188 SHV-188 From the Lahey list of beta-lactamases. SHV-189 antibiotic_resistance ARO:3003156 SHV-189 SHV-189 From the Lahey list of beta-lactamases. TEM-219 antibiotic_resistance ARO:3003157 TEM-219 TEM-219 From the Lahey list of beta-lactamases. TEM-220 antibiotic_resistance ARO:3003158 TEM-220 TEM-220 From the Lahey list of beta-lactamases. Not yet released. antibiotic_resistance ARO:3003159 OXA-419 From the Lahey list of beta-lactamases. OXA-422 antibiotic_resistance ARO:3003160 OXA-422 OXA-422 From the Lahey list of beta-lactamases. OXA-423 antibiotic_resistance ARO:3003161 OXA-423 OXA-423 From the Lahey list of beta-lactamases. OXA-435 antibiotic_resistance ARO:3003162 OXA-435 OXA-435 From the Lahey list of beta-lactamases. CTX-M-155 antibiotic_resistance ARO:3003163 CTX-M-155 CTX-M-155 From the Lahey list of beta-lactamases. CTX-M-156 antibiotic_resistance ARO:3003164 CTX-M-156 CTX-M-156 From the Lahey list of beta-lactamases. CTX-M-157 antibiotic_resistance ARO:3003165 CTX-M-157 CTX-M-157 From the Lahey list of beta-lactamases. CTX-M-158 antibiotic_resistance ARO:3003166 CTX-M-158 CTX-M-158 From the Lahey list of beta-lactamases. CTX-M-159 antibiotic_resistance ARO:3003167 CTX-M-159 CTX-M-159 From the Lahey list of beta-lactamases. CTX-M-160 antibiotic_resistance ARO:3003168 CTX-M-160 CTX-M-160 From the Lahey list of beta-lactamases. CTX-M-161 antibiotic_resistance ARO:3003169 CTX-M-161 CTX-M-161 From the Lahey list of beta-lactamases. CMY-131 antibiotic_resistance ARO:3003170 CMY-131 CMY-131 From the Lahey list of beta-lactamases. ACT-36 antibiotic_resistance ARO:3003171 ACT-36 ACT-36 From the Lahey list of beta-lactamases. ACT-37 antibiotic_resistance ARO:3003172 ACT-37 ACT-37 From the Lahey list of beta-lactamases. MIR-17 antibiotic_resistance ARO:3003173 MIR-17 MIR-17 From the Lahey list of beta-lactamases. CARB-18 antibiotic_resistance ARO:3003174 CARB-18 CARB-18 From the Lahey list of beta-lactamases. CARB-19 antibiotic_resistance ARO:3003175 CARB-19 CARB-19 From the Lahey list of beta-lactamases. CARB-21 antibiotic_resistance ARO:3003176 CARB-21 CARB-21 From the Lahey list of beta-lactamases. IMI-7 antibiotic_resistance ARO:3003177 IMI-7 IMI-7 From the Lahey list of beta-lactamases. VIM-42 antibiotic_resistance ARO:3003178 VIM-42 VIM-42 From the Lahey list of beta-lactamases. VIM-43 antibiotic_resistance ARO:3003179 VIM-43 VIM-43 From the Lahey list of beta-lactamases. KPC-22 antibiotic_resistance ARO:3003180 KPC-22 KPC-22 From the Lahey list of beta-lactamases. GES-26 antibiotic_resistance ARO:3003181 GES-26 GES-26 Beta-lactamase found in Escherichia coli clinical isolates in Nepal. NDM-13 antibiotic_resistance ARO:3003182 NDM-13 Beta-lactamase found in Escherichia coli clinical isolates in Nepal. PMID:26169399 NDM-13 NDM-14 is a beta-lactamase found in Acinetobacter lwoffii. NDM-14 antibiotic_resistance ARO:3003183 NDM-14 NDM-14 is a beta-lactamase found in Acinetobacter lwoffii. PMID:25645836 NDM-14 From the Lahey list of beta-lactamases. PER-8 antibiotic_resistance ARO:3003184 PER-8 PER-8 Assigned by Lahey's list of beta-lactamases, not yet released. GES-25 antibiotic_resistance ARO:3003185 GES-25 GES-25 Present in Lahey's list of beta-lactamases, not yet released. CARB-23 antibiotic_resistance ARO:3003186 CARB-23 CARB-23 QnrB75 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. QnrB75 antibiotic_resistance ARO:3003187 QnrB75 QnrB75 QnrB76 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. QnrB76 antibiotic_resistance ARO:3003188 QnrB76 QnrB76 QnrB77 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. QnrB77 antibiotic_resistance ARO:3003189 QnrB77 QnrB77 QnrB78 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. QnrB78 antibiotic_resistance ARO:3003190 QnrB78 QnrB78 QnrB80 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. QnrB80 antibiotic_resistance ARO:3003192 QnrB80 QnrB80 QnrVC7 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. QnrVC7 antibiotic_resistance ARO:3003193 QnrVC7 QnrVC7 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. PMID:23595824 QnrVC7 GIM-2 is a metallo-beta-lactamase present on an integron found in clinical isolates of Enterobacter cloacae in Germany. GIM-2 antibiotic_resistance ARO:3003194 GIM-2 GIM-2 GIM beta-lactamase enzymes isolated from Pseudomonas aeruginosa, and found to confer broad-spectrum resistance to beta-lactam antibiotics. blaGIM-1 antibiotic_resistance ARO:3003195 GIM beta-lactamase GIM beta-lactamase enzymes isolated from Pseudomonas aeruginosa, and found to confer broad-spectrum resistance to beta-lactam antibiotics. PMID:15561840 Tet45 is a tetracycline efflux pump found in Bhargavaea cecembensis strain previously isolated from a poultry-litter-impacted soil. tet(45) tet45 antibiotic_resistance ARO:3003196 tet(45) Tet45 is a tetracycline efflux pump found in Bhargavaea cecembensis strain previously isolated from a poultry-litter-impacted soil. PMID:22001175 PMID:23595824 tet(45) Streptomycin/spectinomycin resistance gene found in Pasteurella multocida isolated from bovine respiratory tract. aadA25 antibiotic_resistance ARO:3003197 aadA25 Streptomycin/spectinomycin resistance gene found in Pasteurella multocida isolated from bovine respiratory tract. PMID:22001175 aadA25 rmtH is a 16s ribosomal RNA methyltransferase found in Klebsiella pneumoniae strain MRSN2404 that was isolated from the chronic wound of a soldier wounded in Iraq in 2006. It confers high resistance to aminoglycosides. rmtH antibiotic_resistance ARO:3003198 rmtH rmtH is a 16s ribosomal RNA methyltransferase found in Klebsiella pneumoniae strain MRSN2404 that was isolated from the chronic wound of a soldier wounded in Iraq in 2006. It confers high resistance to aminoglycosides. PMID:23478957 rmtH AAC(6')-Iak is a 6'-N-aminoglycoside acetyltransferase-encoding gene isolated from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia. AAC(6')-Iak antibiotic_resistance ARO:3003199 AAC(6')-Iak AAC(6')-Iak is a 6'-N-aminoglycoside acetyltransferase-encoding gene isolated from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia. PMID:25092711 AAC(6')-Iak AAC(6')-Ian is an amikacin acetyltransferase gene found on a transferable plasmid of the Serratia marcescens strain NUBL-11663. It catalyzes the transfer of an acetyl group from acetyl coenzyme A onto an amine at the 6'-position of various aminoglycosides. AAC(6')-Ian antibiotic_resistance ARO:3003200 AAC(6')-Ian AAC(6')-Ian is an amikacin acetyltransferase gene found on a transferable plasmid of the Serratia marcescens strain NUBL-11663. It catalyzes the transfer of an acetyl group from acetyl coenzyme A onto an amine at the 6'-position of various aminoglycosides. PMID:25576529 AAC(6')-Ian The TLA beta-lactamases are resistant to expanded-spectrum cephalosporins, and aztreonam but was susceptible to amikacin, cefotetan, and imipenem. antibiotic_resistance ARO:3003201 TLA beta-lactamase TLA-1 is a beta-lactamase found in plasmids of clinical isolates of Escherichia coli strain R170 in Latin America. It preferentially hydrolyzed cephaloridine, cefotaxime, cephalothin, benzylpenicillin, and ceftazidime. The enzyme was markedly inhibited by sulbactam, tazobactam, and clavulanic acid. TLA-1 antibiotic_resistance ARO:3003202 TLA-1 TLA-1 is a beta-lactamase found in plasmids of clinical isolates of Escherichia coli strain R170 in Latin America. It preferentially hydrolyzed cephaloridine, cefotaxime, cephalothin, benzylpenicillin, and ceftazidime. The enzyme was markedly inhibited by sulbactam, tazobactam, and clavulanic acid. PMID:15095209 TLA-1 TLA-2 is a beta-lactamase is present on a plasmid isolated from an unidentified bacterial strain from a waste water treatment plant. The enzyme mostly hydrolyzes cephalosporins. TLA-2 antibiotic_resistance ARO:3003203 TLA-2 TLA-2 is a beta-lactamase is present on a plasmid isolated from an unidentified bacterial strain from a waste water treatment plant. The enzyme mostly hydrolyzes cephalosporins. PMID:16251326 TLA-2 TLA-3 is a beta-lactamase found in a transferable plasmid of Serratia marcescens clinical isolate. It confers resistance to ceftazidime, cefotaxime and cefepime, but not to cefmetazole and meropenem. TLA-3 antibiotic_resistance ARO:3003204 TLA-3 TLA-3 is a beta-lactamase found in a transferable plasmid of Serratia marcescens clinical isolate. It confers resistance to ceftazidime, cefotaxime and cefepime, but not to cefmetazole and meropenem. PMID:25576529 TLA-3 Erm(43) is a macrolide, lincosamide, and streptogramin B resistance gene found in Mammaliicoccus lentus chromosome isolated from human, dog and chicken. Erm(43) antibiotic_resistance ARO:3003205 Erm(43) Erm(43) is a macrolide, lincosamide, and streptogramin B resistance gene found in Mammaliicoccus lentus chromosome isolated from human, dog and chicken. PMID:22733067 Erm(43) lsaE is an ABC-F subfamily protein found in porcine MRSA isolates. It confers resistance to pleuromutilin, lincosamide, and streptogramin A. lsaE antibiotic_resistance ARO:3003206 lsaE lsaE is an ABC-F subfamily protein found in porcine MRSA isolates. It confers resistance to pleuromutilin, lincosamide, and streptogramin A. PMID:21245447 PMID:23386262 lsaE FosK is a fosfomycin thiol transferase isolated from Acinetobacter soli. It is integrin-mediated. It confers a high level of resistance to fosfomycin. FosK antibiotic_resistance ARO:3003207 FosK FosK is a fosfomycin thiol transferase isolated from Acinetobacter soli. It is integrin-mediated. It confers a high level of resistance to fosfomycin. PMID:24841262 FosK fosXCC is a fosfomycin resistance gene that modifies MurA isolated from Campylobacter species. It is highly resistant to fosfomycin. FosXCC antibiotic_resistance ARO:3003208 FosXCC fosXCC is a fosfomycin resistance gene that modifies MurA isolated from Campylobacter species. It is highly resistant to fosfomycin. PMID:25433007 FosXCC fosA5 is a fosfomycin resistance gene isolated from clinical strain of Escherichia coli E265. It is susceptible to amikacin, tetracycline and imipenem, and resistant to sulphonamide, cephalosporins, gentamicin, ciprofloxacin, chloramphenicol and streptomycin. fosA5 antibiotic_resistance ARO:3003209 fosA5 fosA5 is a fosfomycin resistance gene isolated from clinical strain of Escherichia coli E265. It is susceptible to amikacin, tetracycline and imipenem, and resistant to sulphonamide, cephalosporins, gentamicin, ciprofloxacin, chloramphenicol and streptomycin. PMID:25441705 fosA5 FosA4 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. FosA4 antibiotic_resistance ARO:3003210 FosA4 FosA4 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. PMID:24951800 FosA4 Many antibiotics inhibit the growth of bacteria by blocking protein synthesis on the ribosome. The antibiotic-binding sites are located within functionally important structures in the ribosomal RNA. Antibiotic resistance is often conferred by base substitutions or methylations at these sites in the rRNA. Point mutations in the bacterial 16S ribosomal RNA in the small 30S subunit can confer resistance to antibiotics. antibiotic_resistance ARO:3003211 16S rRNA with mutation conferring antibiotic resistance Many antibiotics inhibit the growth of bacteria by blocking protein synthesis on the ribosome. The antibiotic-binding sites are located within functionally important structures in the ribosomal RNA. Antibiotic resistance is often conferred by base substitutions or methylations at these sites in the rRNA. Point mutations in the bacterial 16S ribosomal RNA in the small 30S subunit can confer resistance to antibiotics. PMID:16261170 PMID:16269538 PMID:8065453 Point mutations in the 3' minor domain of the 16S rRNA in Escherichia coli can confer resistance to edeine. Ecol_16S_EDN antibiotic_resistance ARO:3003223 Escherichia coli 16S rRNA mutation conferring resistance to edeine Point mutations in the 3' minor domain of the 16S rRNA in Escherichia coli can confer resistance to edeine. PMID:16269538 Ecol_16S_EDN Precursor molecule during the synthesis of bacterial cell wall. Lipid II anchors itself onto the cell and it's disaccharide-peptide subunit is used in PG polymer assembly by peptidoglycan glycosyltransferases. Due to it's importance in cell wall synthesis, it is the target of antibiotics. antibiotic_resistance ARO:3003231 Lipid II Precursor molecule during the synthesis of bacterial cell wall. Lipid II anchors itself onto the cell and it's disaccharide-peptide subunit is used in PG polymer assembly by peptidoglycan glycosyltransferases. Due to it's importance in cell wall synthesis, it is the target of antibiotics. PMID:25291014 Lipid III is the precursor to the wall teichoic acid. It's inhibition leads to bacterial death as teichoic acid is required to anchor autolysins which control the hydrolysis of peptidoglycan cell wall. Undecaprenyl Pyrophosphate N-Acetylglucosamine Undecaprenyl-PP-GlcNAc antibiotic_resistance ARO:3003232 Lipid III Lipid III is the precursor to the wall teichoic acid. It's inhibition leads to bacterial death as teichoic acid is required to anchor autolysins which control the hydrolysis of peptidoglycan cell wall. PMID:25561178 Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to kanamycin. Mabs_16S_KAN antibiotic_resistance ARO:3003236 Mycobacteroides abscessus 16S rRNA mutation conferring resistance to kanamycin Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to kanamycin. PMID:21652621 PMID:9607835 Mabs_16S_KAN Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to tobramycin. Mabs_16S_TOB antibiotic_resistance ARO:3003237 Mycobacteroides abscessus 16S rRNA mutation conferring resistance to tobramycin Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to tobramycin. PMID:21652621 PMID:9607835 Mabs_16S_TOB Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to neomycin. Mabs_16S_NEO antibiotic_resistance ARO:3003238 Mycobacteroides abscessus 16S rRNA mutation conferring resistance to neomycin Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to neomycin. PMID:9607835 Mabs_16S_NEO Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to amikacin. Mabs_16S_AMK antibiotic_resistance ARO:3003239 Mycobacteroides abscessus 16S rRNA mutation conferring resistance to amikacin Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to amikacin. PMID:21652621 PMID:9607835 Mabs_16S_AMK Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to gentamicin. Mabs_16S_GEN antibiotic_resistance ARO:3003240 Mycobacteroides abscessus 16S rRNA mutation conferring resistance to gentamicin Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to gentamicin. PMID:21652621 PMID:9607835 Mabs_16S_GEN Teixobactin is a peptide antibiotic isolated from the Gram-negative bacteria, Eleftheria terrae. It inhibits the synthesis of peptidoglycan by interacting with peptidoglycan precursor, Lipid II and Lipid III. pubchem.compound:86341926 antibiotic_resistance ARO:3003241 teixobactin Teixobactin is a peptide antibiotic isolated from the Gram-negative bacteria, Eleftheria terrae. It inhibits the synthesis of peptidoglycan by interacting with peptidoglycan precursor, Lipid II and Lipid III. PMID:25561178 The bcrC gene product (BcrC) is an undecaprenyl pyrophosphate phosphatase originally isolated from Bacillus subtilis. When overexpressed it can confer resistance to bacitracin. bcrC antibiotic_resistance ARO:3003250 bcrC The bcrC gene product (BcrC) is an undecaprenyl pyrophosphate phosphatase originally isolated from Bacillus subtilis. When overexpressed it can confer resistance to bacitracin. PMID:15946938 bcrC Undecaprenyl pyrophosphate is a precursor to a cell wall polymer carrier. It's activation requires a phosphatase. antibiotic_resistance ARO:3003251 undecaprenyl pyrophosphate Subunit of topoisomerase IV sensitive to aminocourmarins. antibiotic_resistance ARO:3003253 aminocoumarin sensitive parY Subunit of topoisomerase IV sensitive to aminocourmarins. PMID:1260451 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling. antibiotic_resistance ARO:3003254 antibiotic sensitive DNA topoisomerase subunit gyrA DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling. PMID:1657531 ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Targeting topoisomerase IV inhibits DNA synthesis, and may also lead to double-stranded cell breaks. antibiotic_resistance ARO:3003256 antibiotic sensitive DNA topoisomerase subunit parC ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Targeting topoisomerase IV inhibits DNA synthesis, and may also lead to double-stranded cell breaks. PMID:1657531 parY is a subunit of the topoisomerase IV. It decatenates and relaxes DNA to allow for transcription or translation. antibiotic_resistance ARO:3003258 Antibiotic sensitive DNA topoisomerase subunit parY ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Targeting topoisomerase IV inhibits DNA synthesis, and may also lead to double-stranded cell breaks. antibiotic_resistance ARO:3003259 antibiotic sensitive DNA topoisomerase subunit parE ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Targeting topoisomerase IV inhibits DNA synthesis, and may also lead to double-stranded cell breaks. PMID:12604514 Beta-subunit of DNA gyrase sensitive to inhibition by aminocoumarins. antibiotic_resistance ARO:3003260 aminocoumarin sensitive gyrB Beta-subunit of DNA gyrase sensitive to inhibition by fluoroquinolones. antibiotic_resistance ARO:3003261 fluoroquinolone sensitive gyrB Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003262 Antibiotic sensitive Escherichia coli 16S rRNA Sensitive form of 16s susceptible to antibiotics. antibiotic_resistance ARO:3003263 Antibiotic sensitive Mycobacteroides abscessus 16S rRNA Sensitive form of 16s susceptible to antibiotics. antibiotic_resistance ARO:3003264 Aminoglycosides sensitive Mycobacteroides abscessus 16S rRNA Sensitive form of 16s susceptible to antibiotics. antibiotic_resistance ARO:3003265 Amikacin sensitive Mycobacteroides abscessus 16S rRNA mutation Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Current known mutations on the enzyme confer resistance to daptomycin. cardiolipin synthetase antibiotic_resistance ARO:3003272 daptomycin resistant cls Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Current known mutations on the enzyme confer resistance to daptomycin. PMID:23114777 PMID:9370333 Interaction with the cell membrane phospholipids interferes with membrane permeability and integrity, leading to the leakage of cell contents. The outer membrane of Gram-negative bacteria is particularly sensitive. antibiotic_resistance ARO:3003273 cell membrane component enzymes targeted by antibiotic Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. The inactivation of this enzyme by antibiotics leads to cell death. antibiotic_resistance ARO:3003274 antibiotic sensitive cls Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Mutations on the enzyme confers resistance to Daptomycin. antibiotic_resistance ARO:3003275 Daptomycin sensitive cardiolipin synthetase Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Mutations on the enzyme confers resistance to Daptomycin. PMID:21899450 RNA polymerase is a multisubunit enzyme that is necessary for transcription. The beta-subunit of RNA polymerase forms the active center of the enzyme and template/transcript binding sites. Mutations in rpoB gene confers antibiotic resistance. RNA polymerase beta subunit antibiotic_resistance ARO:3003276 antibiotic resistant rpoB RNA polymerase is a multisubunit enzyme that is necessary for transcription. The beta-subunit of RNA polymerase forms the active center of the enzyme and template/transcript binding sites. This enzyme can be inactivated by antibiotics leading to cell death. antibiotic_resistance ARO:3003277 antibiotic sensitive beta-subunit of RNA polymerase (rpoB) Daptomycin binds to the cytoplasmic membrane of Gram-positive. It's lipopeptide tail servers as a ion channel for potassium. This causes a rapid depolarization that result in failures in DNA/RNA/Protein synthesis. Eventually cell death. antibiotic_resistance ARO:3003278 daptomycin sensitive beta-subunit of RNA polymerase (rpoB) Daptomycin binds to the cytoplasmic membrane of Gram-positive. It's lipopeptide tail servers as a ion channel for potassium. This causes a rapid depolarization that result in failures in DNA/RNA/Protein synthesis. Eventually cell death. PMID:20837752 The liaFSR system regulates the cell envelope stress response. It is transcriptionally activated by exposure to alkaline shock, detergents, and particularly antibiotics with lipid II inhibition properties. antibiotic_resistance ARO:3003279 antibiotic resistant liaFSR system The liaFSR system regulates the cell envelope stress response. It is transcriptionally activated by exposure to alkaline shock, detergents, and particularly antibiotics with lipid II inhibition properties. PMID:19251860 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Mutations in this enzyme can confer additional resistances. antibiotic_resistance ARO:3003280 antibiotic sensitive mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Mutations in this enzyme can confer additional resistances. PMID:16723576 PMID:20498310 pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. Inhibition of this enzyme leads to cell death via the inability to form the plasma membrane. antibiotic_resistance ARO:3003281 antibiotic sensitive pgsA pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. Inhibition of this enzyme leads to cell death via the inability to form the plasma membrane. PMID:21709092 Point mutations that occurs in Mycobacterium tuberculosis rpoB resulting in resistance to rifampicin. Mtub_rpoB_RIF antibiotic_resistance ARO:3003283 Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin Point mutations that occurs in Mycobacterium tuberculosis rpoB resulting in resistance to rifampicin. PMID:10074552 PMID:10423225 PMID:10645439 PMID:10722516 PMID:10921994 PMID:11136757 PMID:11474030 PMID:11796356 PMID:12454132 PMID:15047531 PMID:15184414 PMID:15728936 PMID:15814606 PMID:17108078 PMID:17360809 PMID:17970586 PMID:18294243 PMID:18600483 PMID:18653964 PMID:19520715 PMID:19547874 PMID:19721079 PMID:21300839 PMID:22708343 PMID:25427352 PMID:28904673 PMID:31100498 PMID:7840574 PMID:7914261 PMID:8027320 PMID:8095569 PMID:8870258 PMID:9003625 Mtub_rpoB_RIF Point mutations that occurs in Mycobacterium leprae rpoB resulting in resistance to rifampicin. Mlep_rpoB_RIF antibiotic_resistance ARO:3003284 Mycobacterium leprae rpoB mutations conferring resistance to rifampicin Point mutations that occurs in Mycobacterium leprae rpoB resulting in resistance to rifampicin. PMID:15603834 Mlep_rpoB_RIF Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to rifampicin. Saur_rpoB_RIF antibiotic_resistance ARO:3003285 Staphylococcus aureus rpoB mutants conferring resistance to rifampicin Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to rifampicin. PMID:10543773 Saur_rpoB_RIF Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to daptomycin. Saur_rpoB_DAP antibiotic_resistance ARO:3003287 Staphylococcus aureus rpoB mutants conferring resistance to daptomycin Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to daptomycin. PMID:16723576 PMID:20837752 Saur_rpoB_DAP Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin. Ecol_rpoB_RIF antibiotic_resistance ARO:3003288 Escherichia coli rpoB mutants conferring resistance to rifampicin Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin. PMID:3050121 PMID:31992637 Ecol_rpoB_RIF RNA polymerase is a multisubunit enzyme that is necessary for transcription. The beta prime subunit of RNA polymerase forms the active center of the enzyme and template/transcript binding sites. Mutations in rpoC gene confers antibiotic resistance. RNA polymerase beta-prime subunit antibiotic_resistance ARO:3003289 antibiotic resistant rpoC Daptomycin resistant RNA polymerases include amino acids substitutions which alter the binding affinity of daptomycin to the protein, resulting in antibiotic resistance. antibiotic_resistance ARO:3003290 daptomycin-resistant beta prime subunit of RNA polymerase (rpoC) Point mutations that occurs in Staphylococcus aureus rpoC resulting in resistance to daptomycin. Saur_rpoC_DAP antibiotic_resistance ARO:3003291 Staphylococcus aureus rpoC conferring resistance to daptomycin Point mutations that occurs in Staphylococcus aureus rpoC resulting in resistance to daptomycin. PMID:16723576 Saur_rpoC_DAP DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. GyrA point mutations confer resistance by preventing fluoroquinolone antibiotics from binding the alpha-subunit. antibiotic_resistance ARO:3003292 fluoroquinolone resistant gyrA DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. GyrA point mutations confer resistance by preventing fluoroquinolone antibiotics from binding the alpha-subunit. PMID:12499219 PMID:1850972 PMID:22279180 PMID:22371897 PMID:9293187 Point mutation of Escherichia coli gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. Ecol_gyrA_FLO antibiotic_resistance ARO:3003294 Escherichia coli gyrA conferring resistance to fluoroquinolones Point mutation of Escherichia coli gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. PMID:1850972 PMID:2168148 PMID:2548439 PMID:25631675 PMID:7840592 PMID:8388197 Ecol_gyrA_FLO Point mutation of Mycobacterium tuberculosis gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. Mtub_gyrA_FLO antibiotic_resistance ARO:3003295 Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones Point mutation of Mycobacterium tuberculosis gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. PMID:16377674 PMID:16584301 PMID:17015625 PMID:17035499 PMID:17434825 PMID:19687244 PMID:21300839 PMID:27847014 PMID:8031045 Mtub_gyrA_FLO Point mutation of Staphylococcus aureus gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. Saur_gyrA_FLO antibiotic_resistance ARO:3003296 Staphylococcus aureus gyrA conferring resistance to fluoroquinolones Point mutation of Staphylococcus aureus gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. PMID:21996946 Saur_gyrA_FLO Point mutation of Bartonella bacilliformis gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. Bbac_gyrA_FLO antibiotic_resistance ARO:3003297 Bartonella bacilliformis gyrA conferring resistance to fluoroquinolones Point mutation of Bartonella bacilliformis gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. PMID:12499219 Bbac_gyrA_FLO Point mutation of Mycobacterium leprae gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. Mlep_gyrA_FLO antibiotic_resistance ARO:3003298 Mycobacterium leprae gyrA conferring resistance to fluoroquinolones Point mutation of Mycobacterium leprae gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. PMID:15603834 Mlep_gyrA_FLO Point mutation in Staphylococcus aureus resulting in aminocoumarin resistance. Saur_gyrB_AMU antibiotic_resistance ARO:3003301 Staphylococcus aureus gyrB conferring resistance to aminocoumarin Point mutation in Staphylococcus aureus resulting in aminocoumarin resistance. PMID:16127057 Saur_gyrB_AMU Point mutation in Bartonella bacilliformis resulting in aminocoumarin resistance. Bbac_gyrA_AMU antibiotic_resistance ARO:3003302 Bartonella bacilliformis gyrB conferring resistance to aminocoumarin Point mutation in Bartonella bacilliformis resulting in aminocoumarin resistance. PMID:9797224 Bbac_gyrA_AMU Point mutation in Escherichia coli resulting in aminocoumarin resistance. Ecol_gyrB_AMU antibiotic_resistance ARO:3003303 Escherichia coli gyrB conferring resistance to aminocoumarin Point mutation in Escherichia coli resulting in aminocoumarin resistance. PMID:1323022 Ecol_gyrB_AMU Point mutation in Mycobacterium leprae gyrB resulting in fluoroquinolone resistance. Mlep_gyrB_FLO antibiotic_resistance ARO:3003304 Mycobacterium leprae gyrB conferring resistance to fluoroquinolones Point mutation in Mycobacterium leprae gyrB resulting in fluoroquinolone resistance. PMID:23071850 Mlep_gyrB_FLO Point mutation in Ureaplasma urealyticum resulting in fluoroquinolone resistance. Uure_gyrB_FLO antibiotic_resistance ARO:3003305 Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones Point mutation in Ureaplasma urealyticum resulting in fluoroquinolone resistance. PMID:25645833 PMID:27884651 Uure_gyrB_FLO Point mutation in Morganella morganii resulting in fluoroquinolone resistance. Mmor_gyrB_FLO antibiotic_resistance ARO:3003306 Morganella morganii gyrB conferring resistance to fluoroquinolones Point mutation in Morganella morganii resulting in fluoroquinolone resistance. PMID:25106550 Mmor_gyrB_FLO Point mutation in Salmonella serovars resulting in fluoroquinolone resistance. Sser_gyrB_FLO antibiotic_resistance ARO:3003307 Salmonella serovars gyrB conferring resistance to fluoroquinolones Point mutation in Salmonella serovars resulting in fluoroquinolone resistance. PMID:19104017 Sser_gyrB_FLO Point mutation in Escherichia coli parC resulting in fluoroquinolone resistance. Ecol_parC_FLO antibiotic_resistance ARO:3003308 Escherichia coli parC conferring resistance to fluoroquinolones Point mutation in Escherichia coli parC resulting in fluoroquinolone resistance. PMID:25631675 Ecol_parC_FLO Point mutation in Ureaplasma urealyticum parC resulting in fluoroquinolone resistance. Uure_parC_FLO antibiotic_resistance ARO:3003309 Ureaplasma urealyticum parC conferring resistance to fluoroquinolones Point mutation in Ureaplasma urealyticum parC resulting in fluoroquinolone resistance. PMID:25645833 PMID:27884651 Uure_parC_FLO Point mutation in Mycoplasma hominis parC resulting in fluoroquinolone resistance. Mhom_23S_FLO antibiotic_resistance ARO:3003310 Mycoplasma hominis parC conferring resistance to fluoroquinolones Point mutation in Mycoplasma hominis parC resulting in fluoroquinolone resistance. PMID:24948939 Mhom_23S_FLO Point mutation in Streptococcus pneumoniae parC resulting in fluoroquinolone resistance. Spne_parC_FLO antibiotic_resistance ARO:3003311 Streptococcus pneumoniae parC conferring resistance to fluoroquinolones Point mutation in Streptococcus pneumoniae parC resulting in fluoroquinolone resistance. PMID:8913454 Spne_parC_FLO Point mutation in Staphylococcus aureus parC resulting in fluoroquinolone resistance. Saur_parC_FLO antibiotic_resistance ARO:3003312 Staphylococcus aureus parC conferring resistance to fluoroquinolones Point mutation in Staphylococcus aureus parC resulting in fluoroquinolone resistance. PMID:21996946 Saur_parC_FLO ParE is a subunit of topoisomerase IV, necessary for cell survival. Point mutations in ParE prevent fluoroquinolones from inhibiting DNA synthesis, thus conferring resistance. antibiotic_resistance ARO:3003313 fluoroquinolone resistant parE Point mutation in Staphylococcus aureus parE resulting in aminocoumarin resistance. Saur_parE_AMU grlB antibiotic_resistance ARO:3003314 Staphylococcus aureus parE conferring resistance to aminocoumarin Point mutation in Staphylococcus aureus parE resulting in aminocoumarin resistance. PMID:16127057 Saur_parE_AMU Point mutation in Staphylococcus aureus parE resulting in fluoroquinolones resistance. Saur_parE_FLO antibiotic_resistance ARO:3003315 Staphylococcus aureus parE conferring resistance to fluoroquinolones Point mutation in Staphylococcus aureus parE resulting in fluoroquinolones resistance. PMID:21996946 Saur_parE_FLO Point mutation in Escherichia coli parE resulting in fluoroquinolones resistance. Ecol_parE_FLO antibiotic_resistance ARO:3003316 Escherichia coli parE conferring resistance to fluoroquinolones Point mutation in Escherichia coli parE resulting in fluoroquinolones resistance. PMID:25631675 Ecol_parE_FLO Point mutation in Salmonella serovars parE resulting in fluoroquinolones resistance. Sser_parE_FLO antibiotic_resistance ARO:3003317 Salmonella serovars parE conferring resistance to fluoroquinolones Point mutation in Salmonella serovars parE resulting in fluoroquinolones resistance. PMID:19104017 Sser_parE_FLO Intrinsically aminocoumarin-resistant parY variant found in Streptomyces, an aminocoumarin-producing genus. Sris_parY_AMU antibiotic_resistance ARO:3003318 Streptomyces rishiriensis parY mutant conferring resistance to aminocoumarin Intrinsically aminocoumarin-resistant parY variant found in Streptomyces, an aminocoumarin-producing genus. PMID:14993313 Sris_parY_AMU Point mutations that occur within Staphylococcus aureus mprF gene resulting in resistance to daptomycin. Saur_mprF_DAP antibiotic_resistance ARO:3003319 Staphylococcus aureus mprF with mutation conferring resistance to daptomycin Point mutations that occur within Staphylococcus aureus mprF gene resulting in resistance to daptomycin. PMID:16723576 PMID:20498310 PMID:22238576 PMID:26055370 Saur_mprF_DAP Point mutations that occur within Staphylococcus aureus pgsA gene resulting in resistance to daptomycin. Saur_pgsA_DAP antibiotic_resistance ARO:3003323 Staphylococcus aureus pgsA mutations conferring resistance to daptomycin Point mutations that occur within Staphylococcus aureus pgsA gene resulting in resistance to daptomycin. PMID:22238576 Saur_pgsA_DAP MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Additionally, large-scale mutations causing loss of function of the gene result in increased susceptibility to daptomycin. Bsub_mprF antibiotic_resistance ARO:3003324 Bacillus subtilis mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Additionally, large-scale mutations causing loss of function of the gene result in increased susceptibility to daptomycin. PMID:19164152 PMID:19915718 PMID:21709092 Bsub_mprF Point mutations that occur within Mycobacterium tuberculosis variant bovis embB gene resulting in resistance to ethambutol. Mbov_embB_EMB antibiotic_resistance ARO:3003325 Mycobacterium tuberculosis variant bovis embB with mutation conferring resistance to ethambutol Point mutations that occur within Mycobacterium tuberculosis variant bovis embB gene resulting in resistance to ethambutol. PMID:25554388 Mbov_embB_EMB Point mutations that occur within Mycobacterium tuberculosis embB gene resulting in resistance to ethambutol. Mtub_embB_EMB antibiotic_resistance ARO:3003326 Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol Point mutations that occur within Mycobacterium tuberculosis embB gene resulting in resistance to ethambutol. PMID:10639358 PMID:11854934 PMID:16377878 PMID:16641474 PMID:16972132 PMID:17360809 PMID:21300839 PMID:21778195 PMID:24392447 PMID:9142129 PMID:9257740 Mtub_embB_EMB Point mutations in Mycobacterium tuberculosis embC that result in lower affinity between ethambutol and EmbC, resulting in resistance. Mtub_embC_EMB antibiotic_resistance ARO:3003327 Mycobacterium tuberculosis embC mutant conferring resistance to ethambutol Point mutations in Mycobacterium tuberculosis embC that result in lower affinity between ethambutol and EmbC, resulting in resistance. PMID:10639358 PMID:16972132 PMID:19010731 PMID:19112008 PMID:20427375 PMID:23995136 PMID:26417605 Mtub_embC_EMB Point mutations in the 3' minor, 3' major, and central domains in the rrsC 16S rRNA gene of Escherichia coli can confer resistance to kasugamicin. Ecol_16rrsC_KAS antibiotic_resistance ARO:3003333 Escherichia coli 16S rRNA (rrsC) mutation conferring resistance to kasugamicin Point mutations in the 3' minor, 3' major, and central domains in the rrsC 16S rRNA gene of Escherichia coli can confer resistance to kasugamicin. PMID:10512710 Ecol_16rrsC_KAS Sequence variants of elongation factor Tu that confer resistance to different classes of antibiotics. antibiotic_resistance ARO:3003356 Antibiotic resistant EF-Tu Sequence variants of Clostridioides difficile elongation factor Tu that confer resistance to elfamycin antibiotics. Cdif_EFTu_ELF antibiotic_resistance ARO:3003357 Clostridioides difficile EF-Tu mutants conferring resistance to elfamycin Sequence variants of Clostridioides difficile elongation factor Tu that confer resistance to elfamycin antibiotics. PMID:22644023 Cdif_EFTu_ELF Sequence variants of Escherichia coli elongation factor Tu that confer resistance to elfamycin antibiotics. antibiotic_resistance ARO:3003358 Escherichia coli EF-Tu mutants conferring resistance to elfamycin Sequence variants of Streptomyces cinnamoneus elongation factor Tu that confer resistance to elfamycin antibiotics. Scin_EFTu_ELF antibiotic_resistance ARO:3003359 Streptomyces cinnamoneus EF-Tu mutants conferring resistance to elfamycin Sequence variants of Streptomyces cinnamoneus elongation factor Tu that confer resistance to elfamycin antibiotics. PMID:9043138 Scin_EFTu_ELF Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to elfamycin antibiotics. antibiotic_resistance ARO:3003360 Planobispora rosea EF-Tu mutants conferring resistance to elfamycin Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to elfamycin antibiotics. PMID:8899707 Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to inhibitor GE2270A. Pros_EFTu_GE2A antibiotic_resistance ARO:3003361 Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to inhibitor GE2270A. PMID:12370016 PMID:8899707 Pros_EFTu_GE2A Sequence variants of Escherichia coli elongation factor Tu that confer resistance to kirromycin. Ecol_EFTu_KIR antibiotic_resistance ARO:3003368 Escherichia coli EF-Tu mutants conferring resistance to kirromycin Sequence variants of Escherichia coli elongation factor Tu that confer resistance to kirromycin. PMID:12370016 PMID:1552908 PMID:7525272 Ecol_EFTu_KIR Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin. Ecol_EFTu_PLV antibiotic_resistance ARO:3003369 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin. PMID:7957075 Ecol_EFTu_PLV Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Enacyloxin IIa. Ecol_EFTu_ENC antibiotic_resistance ARO:3003370 Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Enacyloxin IIa. PMID:10610785 Ecol_EFTu_ENC Point mutations in the 3' major domain of the rrsH 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin. Ecol_16rrsH_SPT antibiotic_resistance ARO:3003372 Escherichia coli 16S rRNA (rrsH) mutation conferring resistance to spectinomycin Point mutations in the 3' major domain of the rrsH 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin. PMID:6330677 Ecol_16rrsH_SPT AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. Kpne_acrR_MULT antibiotic_resistance ARO:3003373 Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. PMID:12936981 PMID:25182649 Kpne_acrR_MULT AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. Kaer_acrR_MULT antibiotic_resistance ARO:3003374 Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. PMID:12121946 Kaer_acrR_MULT Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin. Ecol_16rrsB_SPT antibiotic_resistance ARO:3003376 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to spectinomycin Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin. PMID:2447957 PMID:7885842 PMID:8127669 Ecol_16rrsB_SPT Point mutations in the 3' major domain of helix 35, in the rrnB gene operon for 16S rRNA of Escherichia coli can confer resistance to spectinomycin. Ecol_16S_SPT antibiotic_resistance ARO:3003377 Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to spectinomycin Point mutations in the 3' major domain of helix 35, in the rrnB gene operon for 16S rRNA of Escherichia coli can confer resistance to spectinomycin. PMID:16269538 Ecol_16S_SPT MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB. Ecol_MarR_MULT antibiotic_resistance ARO:3003378 Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB. PMID:10760140 PMID:12027588 PMID:8550435 PMID:8807064 PMID:9333027 PMID:9687412 Ecol_MarR_MULT RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. Sent_ramR antibiotic_resistance ARO:3003379 Salmonella enterica ramR mutants RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. PMID:18443112 PMID:19104017 PMID:19270312 PMID:19778917 Sent_ramR RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. Kpne_ramR antibiotic_resistance ARO:3003380 Klebsiella pneumoniae ramR mutants RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. PMID:25182649 Kpne_ramR SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps. Ecol_soxR_MULT antibiotic_resistance ARO:3003381 Escherichia coli soxR with mutation conferring antibiotic resistance SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps. PMID:11302826 PMID:15980345 PMID:21226770 Ecol_soxR_MULT SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression of many multidrug efflux pumps. Sent_soxR_MULT antibiotic_resistance ARO:3003382 Salmonella enterica soxR with mutation conferring antibiotic resistance SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression of many multidrug efflux pumps. PMID:11302826 PMID:19104017 Sent_soxR_MULT SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. Sent_soxS_MULT antibiotic_resistance ARO:3003383 Salmonella serovars soxS with mutation conferring antibiotic resistance SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. PMID:19104017 Sent_soxS_MULT Mutant forms of the porin Omp36 result in reduced permeability to antibiotics. Kaer_Omp36 antibiotic_resistance ARO:3003385 Klebsiella aerogenes Omp36 Mutant forms of the porin Omp36 result in reduced permeability to antibiotics. PMID:15081418 Kaer_Omp36 Point mutations in Escherichia coli dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. Ecol_folP_SLF antibiotic_resistance ARO:3003386 Escherichia coli folP with mutation conferring resistance to sulfonamides Point mutations in Escherichia coli dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. PMID:9449266 Ecol_folP_SLF Point mutations in Streptococcus pyogenes dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. Spyo_folP_SLF antibiotic_resistance ARO:3003387 Streptococcus pyogenes folP with mutation conferring resistance to sulfonamides Point mutations in Streptococcus pyogenes dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. PMID:9593127 Spyo_folP_SLF Dapsone inhibits bacterial synthesis of dihydrofolic acid by competing with with para-aminobenzoate for the active site of dihydropteroate synthetase. Thus acts as a competitive inhibitor of folP. Point mutation within the folP gene results in lowered affinity of dapsone for folP. antibiotic_resistance ARO:3003388 dapsone resistant dihydropteroate synthase folP Dapsone inhibits bacterial synthesis of dihydrofolic acid by competing with with para-aminobenzoate for the active site of dihydropteroate synthetase. Point mutation within the Mycobacterium leprae folP gene results in lowered affinity of dapsone for folP. Mlep_folP_DAO antibiotic_resistance ARO:3003389 Mycobacterium leprae folP with mutation conferring resistance to dapsone Dapsone inhibits bacterial synthesis of dihydrofolic acid by competing with with para-aminobenzoate for the active site of dihydropteroate synthetase. Point mutation within the Mycobacterium leprae folP gene results in lowered affinity of dapsone for folP. PMID:11709358 PMID:15603834 PMID:21115799 Mlep_folP_DAO The Escherichia coli ompF (oprF) is a nonspecific porin channel involved in the membrane translocation of small hydrophilic molecules, including and especially beta-lactam antibiotics. Mutations in ompF can decrease diffusion of antibiotics across the cellular membrane, thereby decreasing overall susceptibility through absence of porin function. Ecol_ompF_BLA antibiotic_resistance ARO:3003390 Escherichia coli ompF with mutation conferring resistance to beta-lactam antibiotics The Escherichia coli ompF (oprF) is a nonspecific porin channel involved in the membrane translocation of small hydrophilic molecules, including and especially beta-lactam antibiotics. Mutations in ompF can decrease diffusion of antibiotics across the cellular membrane, thereby decreasing overall susceptibility through absence of porin function. PMID:10639355 Ecol_ompF_BLA katG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. Mutations in katG results in inability to activate isoniazid. Over 280 different mutations have been documented in PubMed for katG, with mutations to Ser315 being the most prevalent. Mtub_katG_INH antibiotic_resistance ARO:3003392 Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid katG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. Mutations in katG results in inability to activate isoniazid. Over 280 different mutations have been documented in PubMed for katG, with mutations to Ser315 being the most prevalent. PMID:10645439 PMID:14638486 PMID:16870753 PMID:18508939 PMID:19520719 PMID:20054829 PMID:20211896 PMID:21330112 PMID:22808802 PMID:23744165 PMID:24184004 PMID:24468786 PMID:24626681 PMID:25093512 PMID:26092854 PMID:26157154 PMID:26251830 PMID:28904673 PMID:30583053 PMID:31100498 PMID:34642828 PMID:36635309 PMID:7798673 PMID:8585728 Mtub_katG_INH inhA is a enoyl-acyl carrier reductase used in lipid metabolism and farry acid biosynthesis. It is inhibited by isoniazid. mutations in the promoter region or multiple copies of the inhA shows marked resistance to isoniazid mediated inhibition of mycolic acid biosynthesis. Mtub_inhA_INH antibiotic_resistance ARO:3003393 Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid inhA is a enoyl-acyl carrier reductase used in lipid metabolism and farry acid biosynthesis. It is inhibited by isoniazid. mutations in the promoter region or multiple copies of the inhA shows marked resistance to isoniazid mediated inhibition of mycolic acid biosynthesis. PMID:14638486 PMID:16495272 PMID:16870753 PMID:21300839 PMID:22808802 PMID:23539241 PMID:30583053 PMID:7637495 PMID:8284673 PMID:9728546 Mtub_inhA_INH pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide. Some mutation within pncA are associated with loss of enzyme activity, resulting in pyrazinamide resistance. Mtub_pncA_PZA antibiotic_resistance ARO:3003394 Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide. Some mutation within pncA are associated with loss of enzyme activity, resulting in pyrazinamide resistance. PMID:10390238 PMID:10390239 PMID:10471589 PMID:10681313 PMID:10813147 PMID:11083630 PMID:11158123 PMID:11429043 PMID:11641519 PMID:17360809 PMID:17596354 PMID:19234602 PMID:21300839 PMID:25336456 PMID:31910878 PMID:36209317 PMID:9055989 PMID:9056006 PMID:9692180 Mtub_pncA_PZA Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. Amino acid substitutions in RpsL affect the higher-order structure of 16S rRNA and confer streptomycin resistance by disrupting interactions between 16S rRNA and streptomycin. Mtub_rpsL_STR antibiotic_resistance ARO:3003395 Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. Amino acid substitutions in RpsL affect the higher-order structure of 16S rRNA and confer streptomycin resistance by disrupting interactions between 16S rRNA and streptomycin. PMID:15305490 PMID:17238915 PMID:22943573 PMID:7934937 PMID:7968530 PMID:8849220 Mtub_rpsL_STR Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to gentamicin C. Ecol_16S_GENC antibiotic_resistance ARO:3003396 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to gentamicin C Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to gentamicin C. PMID:11502507 Ecol_16S_GENC Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to G418. Ecol_16S_G418 antibiotic_resistance ARO:3003397 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to G418 Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to G418. PMID:11502507 Ecol_16S_G418 Undecaprenyl phosphate is a universal lipid carrier of glycan biosynthetic intermediates for carbohydrate polymers that are exported to the bacterial cell envelope. Antibiotics that targets this compound or proteins associated with the production of this compound leads to cell death. antibiotic_resistance ARO:3003398 undecaprenyl pyrophosphate related proteins Undecaprenyl phosphate is a universal lipid carrier of glycan biosynthetic intermediates for carbohydrate polymers that are exported to the bacterial cell envelope. Antibiotics that targets this compound or proteins associated with the production of this compound leads to cell death. PMID:17660416 Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to kanamycin A. Ecol_16rrsB_KAN antibiotic_resistance ARO:3003399 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to kanamycin A Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to kanamycin A. PMID:11502507 Ecol_16rrsB_KAN A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium laprae. Its mechanism of action involves inhibition of folic acid synthesis in susceptible organisms. antibiotic_resistance ARO:3003401 sulfone antibiotic Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to neomycin. Ecol_16rrsB_NEO antibiotic_resistance ARO:3003402 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to neomycin Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to neomycin. PMID:11502507 Ecol_16rrsB_NEO Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to paromomycin. Ecol_16rrsB_PAR antibiotic_resistance ARO:3003403 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to paromomycin Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to paromomycin. PMID:11502507 Ecol_16rrsB_PAR Point mutations in the 5' domain of helix 18, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin. Ecol_16rrsB_STR antibiotic_resistance ARO:3003405 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to streptomycin Point mutations in the 5' domain of helix 18, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin. PMID:3054810 Ecol_16rrsB_STR Point mutations in the 5' domain of helix 18, in the rrnB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin. Ecol_16S_STR antibiotic_resistance ARO:3003406 Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to streptomycin Point mutations in the 5' domain of helix 18, in the rrnB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin. PMID:16269538 Ecol_16S_STR Point mutations in the 3' minor domain of the rrnB 16S rRNA gene of Escherichia coli can confer resistance to tobramycin. Ecol_16rrsB_TOB antibiotic_resistance ARO:3003408 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tobramycin Point mutations in the 3' minor domain of the rrnB 16S rRNA gene of Escherichia coli can confer resistance to tobramycin. PMID:11502507 Ecol_16rrsB_TOB Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline. Ecol_16rrsB_TET antibiotic_resistance ARO:3003410 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tetracycline Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline. PMID:9661007 Ecol_16rrsB_TET Point mutations in the 3' major domain of the rrnB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline. Ecol_16S_TET antibiotic_resistance ARO:3003411 Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to tetracycline Point mutations in the 3' major domain of the rrnB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline. PMID:16269538 Ecol_16S_TET Dapsone is a sulfone in which it inhibits folic acid synthesis, such as the dihydropteroate synthase. pubchem.compound:2955 diaminodiphenyl sulfone antibiotic_resistance ARO:3003412 dapsone Pyrazinamide is an antimycobacterial. It is highly specific and active only against Mycobacterium tuberculosis. This compound is a prodrug and needs to be activated inside the cell. It interferes with the bacterium's ability to synthesize new fatty acids, causing cell death. pubchem.compound:1046 antibiotic_resistance ARO:3003413 pyrazinamide Pyrazinamide is an antimycobacterial. It is highly specific and active only against Mycobacterium tuberculosis. This compound is a prodrug and needs to be activated inside the cell. It interferes with the bacterium's ability to synthesize new fatty acids, causing cell death. PMID:26104205 LFF571 is a novel semi-synthetic thiopeptide antibiotic derived from GE2270. It has been shown to possess potent in vitro and in vivo activity against Gram-positive bacteria. It is hypothesized that it a translation inhibitor leading to cell death. pubchem.compound:42638236 antibiotic_resistance ARO:3003414 LFF571 LFF571 is a novel semi-synthetic thiopeptide antibiotic derived from GE2270. It has been shown to possess potent in vitro and in vivo activity against Gram-positive bacteria. It is hypothesized that it a translation inhibitor leading to cell death. PMID:22644023 Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. antibiotic_resistance ARO:3003415 sulfonamide resistant dihydropteroate synthase folP Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. It is a catalase-peroxidases that catalyzes the activation of isoniazid. Mutations that arises within this protein cause changes that results in the inability for katG to activate antibiotics, conferring resistance. catalase-peroxidases antibiotic_resistance ARO:3003416 isoniazid resistant katG inhA is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. It is inhibited by isoniazid. Mutations in the promoter region or multiple copies of the inhA shows marked resistance to isoniazid mediated inhibition of mycolic acid biosynthesis. enoyl-acyl carrier reductase antibiotic_resistance ARO:3003417 antibiotic resistant inhA inhA is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. It is inhibited by isoniazid. Mutations in the promoter region or multiple copies of the inhA shows marked resistance to isoniazid mediated inhibition of mycolic acid biosynthesis. PMID:8284673 pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide to pyrazinoic acid. Mutations arise within the pncA gene that caused the loss of pyrazinamidase activity is the major mechanism of antibiotic resistance. nicotinamidase antibiotic_resistance ARO:3003418 Pyrazinamide resistant pncA pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide to pyrazinoic acid. Mutations arise within the pncA gene that caused the loss of pyrazinamidase activity is the major mechanism of antibiotic resistance. PMID:9055989 Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. Amino acid substitutions in RpsL affect the higher-order structure of 16S rRNA and confer antibiotic resistance. Ribosomal protein S12 antibiotic_resistance ARO:3003419 antibiotic-resistant rpsL pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. It is a CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase. phosphatidylglycerophosphate synthetase antibiotic_resistance ARO:3003420 antibiotic resistant pgsA Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins). Phosphatidylglycerol lysyltransferase antibiotic_resistance ARO:3003421 antibiotic resistant mprF Arabinofuranosyltransferase is involved in the biosynthesis of the arabinogalactan region of the mAGP complex, an essential component of the mycobacterial cell wall. antibiotic_resistance ARO:3003422 antibiotic resistant aftA Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. antibiotic_resistance ARO:3003425 antibiotic resistant dihydrofolate reductase inhA is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. antibiotic_resistance ARO:3003426 antibiotic sensitive inhA Porin proteins permeable to antibiotics. antibiotic_resistance ARO:3003428 porin proteins permeable to antibiotics RNA polymerase is a multisubunit enzyme that is necessary for transcription. The beta-prime subunit of RNA polymerase forms the active center of the enzyme and template/transcript binding sites. This enzyme can be inactivated by antibiotics leading to cell death. antibiotic_resistance ARO:3003429 antibiotic sensitive beta-prime subunit of RNA polymerase (rpoC) ParE is a subunit of topoisomerase IV, necessary for cell survival. Point mutations in ParE prevent fluoroquinolones from inhibiting DNA synthesis, thus conferring resistance. antibiotic_resistance ARO:3003430 fluoroquinolone sensitive parE Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. It is targeted and inhibited by streptomycin. antibiotic_resistance ARO:3003431 antibiotic sensitive Ribosomal protein S12 (rpsL) Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to kanamycin. Mtub_16S_KAN antibiotic_resistance ARO:3003436 Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to kanamycin Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to kanamycin. PMID:9244267 PMID:9574680 Mtub_16S_KAN Peptide antibiotics inhibit protein synthesis. Resistance to viomycin can be caused by an altered RNA molecule in the 16S ribosomal subunit. Mtub_16S_VIO antibiotic_resistance ARO:3003437 Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to viomycin Peptide antibiotics inhibit protein synthesis. Resistance to viomycin can be caused by an altered RNA molecule in the 16S ribosomal subunit. PMID:9244267 Mtub_16S_VIO Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to GE2270A. Efac_EFTu_GE2A antibiotic_resistance ARO:3003438 Enterococcus faecium EF-Tu mutants conferring resistance to GE2270A Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to GE2270A. PMID:7989561 Efac_EFTu_GE2A The switch region is a structural element that mediates conformational changes and contacts required for RNAP to load DNA into the RNAP active-center cleft during transcription initiation. The switch region is located at the base of the RNAP clamp and serves as the hinge that mediates opening of the RNAP clamp to load DNA into the RNAP active-center cleft and mediates closing of the RNAP clamp to retain DNA in the RNAP active-center cleft. antibiotic_resistance ARO:3003439 antibiotic sensitive RNA polymerase switch region The switch region is a structural element that mediates conformational changes and contacts required for RNAP to load DNA into the RNAP active-center cleft during transcription initiation. The switch region is located at the base of the RNAP clamp and serves as the hinge that mediates opening of the RNAP clamp to load DNA into the RNAP active-center cleft and mediates closing of the RNAP clamp to retain DNA in the RNAP active-center cleft. PMID:21862392 A foreign PBP2 acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams. PBP2B mecB antibiotic_resistance ARO:3003440 mecB A foreign PBP2 acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams. PMID:24302651 mecB CfrA is a chloramphenicol-florfenicol resistance gene and methyltransferase enzyme. Methylation of position 8 of A2503 in 23S rRNA confers resistance to chloramphenicol antibiotics first identified by Schwarz 2000 as cfr from Mammaliicoccus sciuri. Additional Oxazolidinone resistance mediated by the cfr gene in a human isolated was first reported from Colombia in linezolid- and methicillin-resistant Staphylococcus aureus. cfr cfr(A) cfrA antibiotic_resistance ARO:3003441 cfrA CfrA is a chloramphenicol-florfenicol resistance gene and methyltransferase enzyme. Methylation of position 8 of A2503 in 23S rRNA confers resistance to chloramphenicol antibiotics first identified by Schwarz 2000 as cfr from Mammaliicoccus sciuri. Additional Oxazolidinone resistance mediated by the cfr gene in a human isolated was first reported from Colombia in linezolid- and methicillin-resistant Staphylococcus aureus. PMID:10952608 PMID:15700955 PMID:17145796 PMID:18174304 PMID:28663118 cfrA tlyA encodes for hemolysin. It Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Mutation that arise within this gene reduces the binding affinity of aminoglycosides to rRNA. antibiotic_resistance ARO:3003443 Antibiotic resistant tlyA tlyA encodes for hemolysin. It Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Mutation that arise within this gene reduces the binding affinity of aminoglycosides to rRNA. PMID:15673735 Specific mutations that arise in Mycobacterium tuberculosis tlyA resulting in aminoglycosides resistance. Mtub_tlyA_AMG antibiotic_resistance ARO:3003445 Mycobacterium tuberculosis tlyA mutations conferring resistance to aminoglycosides Specific mutations that arise in Mycobacterium tuberculosis tlyA resulting in aminoglycosides resistance. PMID:15673735 Mtub_tlyA_AMG iniA, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell. antibiotic_resistance ARO:3003446 Antibiotic resistant iniA iniA, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell. PMID:15752203 Mutations that occurs on the iniA genes resulting in the resistance to ethambutol. antibiotic_resistance ARO:3003447 Ethambutol resistant iniA Specific mutations in Mycobacterium tuberculosis iniA resulting in resistance to ethambutol. Mtub_iniA_EMB antibiotic_resistance ARO:3003448 Mycobacterium tuberculosis iniA mutant conferring resistance to ethambutol Specific mutations in Mycobacterium tuberculosis iniA resulting in resistance to ethambutol. PMID:10639358 PMID:12654653 Mtub_iniA_EMB iniC, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell. antibiotic_resistance ARO:3003449 Antibiotic resistant iniC iniC, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell. PMID:15752203 Mutations that occurs on the iniC genes resulting in the resistance to ethambutol. antibiotic_resistance ARO:3003450 Ethambutol resistant iniC Specific mutations that occurs on Mycobacterium tuberculosis iniC causing it to be ethambutol resistant. Mtub_iniC_EMB antibiotic_resistance ARO:3003451 Mycobacterium tuberculosis iniC mutant conferring resistance to ethambutol Specific mutations that occurs on Mycobacterium tuberculosis iniC causing it to be ethambutol resistant. PMID:10639358 PMID:12654653 PMID:16272473 Mtub_iniC_EMB Mutations that occurs on the embA genes resulting in the resistance to ethambutol. antibiotic_resistance ARO:3003452 ethambutol resistant embA Specific mutations that occurs on Mycobacterium tuberculosis embA leading to the lowered affinity of ethambutol to embA. Mtub_embA_EMB antibiotic_resistance ARO:3003453 Mycobacterium tuberculosis embA mutant conferring resistance to ethambutol Specific mutations that occurs on Mycobacterium tuberculosis embA leading to the lowered affinity of ethambutol to embA. PMID:10639358 Mtub_embA_EMB Mutations that occurs on the embR genes resulting in the resistance to ethambutol. antibiotic_resistance ARO:3003454 ethambutol resistant embR Point mutation in the M.tuberculosis embR results in increased resistance to ethambutol. Mtub_embR_EMB antibiotic_resistance ARO:3003455 Mycobacterium tuberculosis embR mutant conferring resistance to ethambutol Point mutation in the M.tuberculosis embR results in increased resistance to ethambutol. PMID:10639358 Mtub_embR_EMB Monooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. It is responsible for the activation of several thiocarbamide-containing pro-drugs into cytotoxic species. FAD-containing monooxygenase antibiotic_resistance ARO:3003456 antibiotic resistant ethA Monooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. It is responsible for the activation of several thiocarbamide-containing pro-drugs into cytotoxic species. PMID:10869356 Mutations that occurs on the ethA genes resulting in the inability to catalyzes the oxidation of ethionamide (ETH) to the corresponding sulfoxide (the active drug). antibiotic_resistance ARO:3003457 ethionamide resistant ethA Specific mutations that occurs on Mycobacterium tuberculosis ethA causing it to be ethionamide resistant. Mtub_ethA_ETO antibiotic_resistance ARO:3003458 Mycobacterium tuberculosis ethA with mutation conferring resistance to ethionamide Specific mutations that occurs on Mycobacterium tuberculosis ethA causing it to be ethionamide resistant. PMID:10944230 PMID:14638486 PMID:28993337 Mtub_ethA_ETO Point mutation in Mycobacterium tuberculosis gyrB resulting in fluoroquinolone resistance. Mtub_gyrB_FLO antibiotic_resistance ARO:3003459 Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolones Point mutation in Mycobacterium tuberculosis gyrB resulting in fluoroquinolone resistance. PMID:16377674 PMID:22761889 Mtub_gyrB_FLO ndh is a NADH oxidase. It participates in antibiotic resistance by diminishing NADH oxidation and consequently causes an increase in NADH concentration and depletion of NAD+. This alteration of the NADH/NAD+ ratio prevents the peroxidation reactions required for the activation of INH, as well as the displacement of the NADH-isonicotinic acyl complex from InhA enzyme binding site. antibiotic_resistance ARO:3003460 antibiotic resistant ndh ndh is a NADH oxidase. It participates in antibiotic resistance by diminishing NADH oxidation and consequently causes an increase in NADH concentration and depletion of NAD+. This alteration of the NADH/NAD+ ratio prevents the peroxidation reactions required for the activation of INH, as well as the displacement of the NADH-isonicotinic acyl complex from InhA enzyme binding site. PMID:17294000 Point mutations in the Mycobacterium tuberculosis ndh gene shown clinically to confer resistance to isoniazid. Mtub_ndh_INH antibiotic_resistance ARO:3003461 Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid Point mutations in the Mycobacterium tuberculosis ndh gene shown clinically to confer resistance to isoniazid. PMID:17294000 PMID:24855126 PMID:26104204 PMID:26311839 PMID:26369965 PMID:30583053 Mtub_ndh_INH kasA is a ketoacyl acyl carrier protein synthase that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. It is involved in elongation of fatty acids intermediate in the biosynthetic pathway of mycolic acids. antibiotic_resistance ARO:3003462 antibiotic resistant kasA kasA is a ketoacyl acyl carrier protein synthase that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. It is involved in elongation of fatty acids intermediate in the biosynthetic pathway of mycolic acids. PMID:10428945 Specific mutations on the Mycobacterium tuberculosis kasA gene resulting in lowered affinity of isoniazid, resulting in resistance. Mtub_kasA_INH antibiotic_resistance ARO:3003463 Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid Specific mutations on the Mycobacterium tuberculosis kasA gene resulting in lowered affinity of isoniazid, resulting in resistance. PMID:10428945 PMID:9616124 Mtub_kasA_INH Arabinosyl transferases allow for the polymerization of arabinose to form arabinan. Arabanan is required for formation of mycobacterial cell walls and arabinosyltransferases are targets of the drug ethambutol. Mutations in these genes can confer resistance to rifampicin. antibiotic_resistance ARO:3003464 rifamycin-resistant arabinosyltransferase Arabinosyl transferases allow for the polymerization of arabinose to form arabinan. Arabanan is required for formation of mycobacterial cell walls and arabinosyltransferases are targets of the drug ethambutol. Mutations in these genes can confer resistance to rifampicin. PMID:17846128 Specific mutations that occurs on Mycobacterium tuberculosis embB causing it to be rifampicin resistant. Mtub_embB_RIF antibiotic_resistance ARO:3003465 Mycobacterium tuberculosis embB with mutation conferring resistance to rifampicin Specific mutations that occurs on Mycobacterium tuberculosis embB causing it to be rifampicin resistant. PMID:17846128 Mtub_embB_RIF GidB is a m7G methyltransferase specific for 16S rRNA. Mutations within the gidB gene causes changes in the structure or 16s rRNA, leading to resistance to aminoglycosides. rsmG antibiotic_resistance ARO:3003466 antibiotic resistant gidB Specific mutations that occurs on Mycobacterium tuberculosis gidB causing it to be streptomycin resistant. Mtub_gidB_STR antibiotic_resistance ARO:3003470 Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin Specific mutations that occurs on Mycobacterium tuberculosis gidB causing it to be streptomycin resistant. PMID:17238915 PMID:18541729 PMID:21444711 PMID:21593257 PMID:31100498 PMID:31934102 PMID:32014024 Mtub_gidB_STR Wildtype embR is sensitive to antibiotics. It is an arabinosyltransferase involved in lipoarabinomannan synthesis. antibiotic_resistance ARO:3003473 Antibiotic sensitive embR Ethionamide is a second-line antitubercular agent that inhibits mycolic acid synthesis. pubchem.compound:2761171 antibiotic_resistance ARO:3003474 ethionamide ethA is a monooxygenase that is able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. Is responsible for the activation of several thiocarbamide-containing pro-drugs into cytotoxic species. antibiotic_resistance ARO:3003475 Antibiotic sensitive ethA It Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. antibiotic_resistance ARO:3003476 antibiotic sensitive tlyA GidB is a m7G methyltransferase specific for 16S rRNA. rsmG antibiotic_resistance ARO:3003477 antibiotic sensitive gidB GidB is a m7G methyltransferase specific for 16S rRNA. PMID:17238915 kasA is a ketoacyl acyl carrier protein synthase that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. It is involved in elongation of fatty acids intermediate in the biosynthetic pathway of mycolic acids. antibiotic_resistance ARO:3003478 antibiotic sensitive kasA TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. Mutations arise within tetR results in lower affinity for tetracyclin. tetR antibiotic_resistance ARO:3003479 tetR TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. Mutations arise within tetR results in lower affinity for tetracyclin. PMID:3062183 tetR Point mutations within the 530 loop of the 16S rRNA of Mycobacterium tuberculosis can result in resistance against streptomycin. These mutations do not directly inhibit the binding of streptomycin, but is hypothesized that they interfere with conformational perturbations that account for streptomycin's action on the ribosome. Mtub_16S_STR antibiotic_resistance ARO:3003480 Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to streptomycin Point mutations within the 530 loop of the 16S rRNA of Mycobacterium tuberculosis can result in resistance against streptomycin. These mutations do not directly inhibit the binding of streptomycin, but is hypothesized that they interfere with conformational perturbations that account for streptomycin's action on the ribosome. PMID:18541729 PMID:35072512 PMID:7934937 PMID:8192448 PMID:8913445 PMID:9244267 Mtub_16S_STR Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to amikacin. Mtub_16S_AMK antibiotic_resistance ARO:3003481 Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to amikacin Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to amikacin. PMID:9593173 Mtub_16S_AMK Point mutation in the 16S rRNA helix 34 region of Chlamydophila psittaci can confer resistance against spectinomycin. Cpsi_16S_SPT antibiotic_resistance ARO:3003485 Chlamydophila psittaci 16S rRNA mutation conferring resistance to spectinomycin Point mutation in the 16S rRNA helix 34 region of Chlamydophila psittaci can confer resistance against spectinomycin. PMID:15980362 Cpsi_16S_SPT Point mutations in the helix 34 region of 16S rRNA of Pasteurella multocida can confer resistance to spectinomycin. Pmul_16S_SPT antibiotic_resistance ARO:3003493 Pasteurella multocida 16S rRNA mutation conferring resistance to spectinomycin Point mutations in the helix 34 region of 16S rRNA of Pasteurella multocida can confer resistance to spectinomycin. PMID:17371823 Pmul_16S_SPT Point mutations in the helix 34 region of 16S rRNA of Neisseria gonorrhoeae can confer resistance against spectinomycin. Ngon_16S_SPT antibiotic_resistance ARO:3003495 Neisseria gonorrhoeae 16S rRNA mutation conferring resistance to spectinomycin Point mutations in the helix 34 region of 16S rRNA of Neisseria gonorrhoeae can confer resistance against spectinomycin. PMID:10770780 Ngon_16S_SPT Point mutations in the 16S rRNA of Neisseria meningitidis can confer resistance to spectinomycin. Nmen_16S_SPT antibiotic_resistance ARO:3003497 Neisseria meningitidis 16S rRNA mutation conferring resistance to spectinomycin Point mutations in the 16S rRNA of Neisseria meningitidis can confer resistance to spectinomycin. PMID:10770780 Nmen_16S_SPT Tetracycline binds tightly to the helix 34 domain in 16S rRNA, where it interferes sterically with the binding of aminoacyl-tRNA to the ribosome A site to block protein synthesis. Mutations in the nucleotide sequence in this domain for Cutibacterium acnes can result in resistance against tetracycline. Cacn_16S_TET antibiotic_resistance ARO:3003499 Cutibacterium acnes 16S rRNA mutation conferring resistance to tetracycline Tetracycline binds tightly to the helix 34 domain in 16S rRNA, where it interferes sterically with the binding of aminoacyl-tRNA to the ribosome A site to block protein synthesis. Mutations in the nucleotide sequence in this domain for Cutibacterium acnes can result in resistance against tetracycline. PMID:9661007 Cacn_16S_TET Point mutations in the 3' major domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to spectinomycin. Bbur_16S_SPT antibiotic_resistance ARO:3003502 Borreliella burgdorferi 16S rRNA mutation conferring resistance to spectinomycin Point mutations in the 3' major domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to spectinomycin. PMID:16436695 Bbur_16S_SPT Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to kanamycin. Bbur_16S_KAN antibiotic_resistance ARO:3003503 Borreliella burgdorferi 16S rRNA mutation conferring resistance to kanamycin Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to kanamycin. PMID:16436695 Bbur_16S_KAN Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to gentamicin. Bbur_16S_GEN antibiotic_resistance ARO:3003504 Borreliella burgdorferi 16S rRNA mutation conferring resistance to gentamicin Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to gentamicin. PMID:16436695 Bbur_16S_GEN Tetracycline binds tightly to the helix 34 domain in 16S rRNA, where it interferes sterically with the binding of aminoacyl-tRNA to the ribosome A site to block protein synthesis. Mutations in the nucleotide sequence in this domain of Helicobacter pylori can result in resistance against tetracycline. Hpyl_16S_TET antibiotic_resistance ARO:3003510 Helicobacter pylori 16S rRNA mutation conferring resistance to tetracycline Tetracycline binds tightly to the helix 34 domain in 16S rRNA, where it interferes sterically with the binding of aminoacyl-tRNA to the ribosome A site to block protein synthesis. Mutations in the nucleotide sequence in this domain of Helicobacter pylori can result in resistance against tetracycline. PMID:11914344 PMID:12183259 PMID:12435699 PMID:20035020 Hpyl_16S_TET SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. Ecol_soxS_MULT antibiotic_resistance ARO:3003511 Escherichia coli soxS with mutation conferring antibiotic resistance SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. PMID:25921515 Ecol_soxS_MULT Point mutations in the helix 34 region of the rrsD 16S rRNA gene of Salmonella enterica serovar Typhimurium can confer resistance to spectinomycin. Sent_16S_SPT antibiotic_resistance ARO:3003512 Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin Point mutations in the helix 34 region of the rrsD 16S rRNA gene of Salmonella enterica serovar Typhimurium can confer resistance to spectinomycin. PMID:12402084 Sent_16S_SPT Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to amikacin. Mche_16S_AMK antibiotic_resistance ARO:3003514 Mycobacteroides chelonae 16S rRNA mutation conferring resistance to amikacin Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to amikacin. PMID:9607835 Mche_16S_AMK Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to kanamycin A. Mche_16S_KAN antibiotic_resistance ARO:3003515 Mycobacteroides chelonae 16S rRNA mutation conferring resistance to kanamycin A Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to kanamycin A. PMID:9607835 Mche_16S_KAN Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to tobramycin. Mche_16S_TOB antibiotic_resistance ARO:3003516 Mycobacteroides chelonae 16S rRNA mutation conferring resistance to tobramycin Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to tobramycin. PMID:9607835 Mche_16S_TOB Point mutations in the 16S rRNA of Mycobacteroides chelonae can confer resistance to gentamicin C. Mche_16S_GENC antibiotic_resistance ARO:3003517 Mycobacteroides chelonae 16S rRNA mutation conferring resistance to gentamicin C Point mutations in the 16S rRNA of Mycobacteroides chelonae can confer resistance to gentamicin C. PMID:9607835 Mche_16S_GENC Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to neomycin. Mche_16S_NEO antibiotic_resistance ARO:3003518 Mycobacteroides chelonae 16S rRNA mutation conferring resistance to neomycin Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to neomycin. PMID:9607835 Mche_16S_NEO Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003520 Antibiotic sensitive Borreliella burgdorferi 16S rRNA Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003521 Antibiotic sensitive Chlamydophila psittaci 16S rRNA Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003522 Antibiotic sensitive Helicobacter pylori 16S rRNA Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003523 Antibiotic sensitive Mycobacteroides chelonae 16S rRNA Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003524 Antibiotic sensitive Mycolicibacterium smegmatis 16S rRNA Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003525 Antibiotic sensitive Neisseria gonorrhoeae 16S rRNA Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003526 Antibiotic sensitive Neisseria meningitidis 16S rRNA Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003527 Antibiotic sensitive Pasteurella multocida 16S rRNA Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003528 Antibiotic sensitive Cutibacterium acnes 16S rRNA Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003529 Antibiotic sensitive Salmonella enterica serovar Typhimurium 16S rRNA Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003530 Antibiotic sensitive Mycobacterium tuberculosis 16S rRNA Point mutations in the highly conserved helix 44 of the 16S rrsA rRNA gene of Mycolicibacterium smegmatis can confer resistance to hygromycin B. Resistance against hygromycin B is the result of conformational alterations that distorts a strong hydrogen bond leading to a change in the local geometry of the hygromycin B binding site. Msme_16rrsA_HGM antibiotic_resistance ARO:3003539 Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to hygromycin B Point mutations in the highly conserved helix 44 of the 16S rrsA rRNA gene of Mycolicibacterium smegmatis can confer resistance to hygromycin B. Resistance against hygromycin B is the result of conformational alterations that distorts a strong hydrogen bond leading to a change in the local geometry of the hygromycin B binding site. PMID:12709313 Msme_16rrsA_HGM Point mutations in the highly conserved helix 44 of the 16S rrsB rRNA gene of Mycolicibacterium smegmatis can confer resistance to hygromycin B. Resistance against hygromycin B is the result of conformational alterations that distorts a strong hydrogen bond leading to a change in the local geometry of the hygromycin B binding site. Msme_16rrsB_HGM antibiotic_resistance ARO:3003540 Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to hygromycin B Point mutations in the highly conserved helix 44 of the 16S rrsB rRNA gene of Mycolicibacterium smegmatis can confer resistance to hygromycin B. Resistance against hygromycin B is the result of conformational alterations that distorts a strong hydrogen bond leading to a change in the local geometry of the hygromycin B binding site. PMID:12709313 Msme_16rrsB_HGM Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to streptomycin. Msme_16rrsB_STR antibiotic_resistance ARO:3003541 Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to streptomycin Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to streptomycin. PMID:11557484 Msme_16rrsB_STR Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A. Msme_16rrsB_KAN antibiotic_resistance ARO:3003542 Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to kanamycin A Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A. PMID:9244267 Msme_16rrsB_KAN Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A. Msme_16rrsA_KAN antibiotic_resistance ARO:3003543 Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to kanamycin A Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A. PMID:9244267 Msme_16rrsA_KAN Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to neomycin. Msme_16rrsA_NEO antibiotic_resistance ARO:3003544 Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to neomycin Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to neomycin. PMID:9244267 Msme_16rrsA_NEO Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to neomycin. Msme_16rrsB_NEO antibiotic_resistance ARO:3003545 Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to neomycin Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to neomycin. PMID:9244267 Msme_16rrsB_NEO Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to viomycin. Msme_16rrsA_VIO antibiotic_resistance ARO:3003546 Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to viomycin Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to viomycin. PMID:9244267 Msme_16rrsA_VIO Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to viomycin. Msme_16rrsB_VIO antibiotic_resistance ARO:3003547 Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to viomycin Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to viomycin. PMID:9244267 Msme_16rrsB_VIO Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. mdtN sdsR yjcR antibiotic_resistance ARO:3003548 mdtN Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. PMID:11257026 PMID:19429622 PMID:8021163 mdtN Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. mdtO sdsQ yjcQ antibiotic_resistance ARO:3003549 mdtO Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. PMID:11257026 PMID:19429622 mdtO Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. mdtP sdsP yjcP antibiotic_resistance ARO:3003550 mdtP Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. PMID:11257026 PMID:19429622 mdtP A multidrug efflux pump from Enterococcus faecalis. There exist efflux activity of several antimicrobial agents such as DAPI, Hoechst 33342 and acriflavine. Efflux of DAPI via EmeA was strongly inhibited by reserpine. emeA antibiotic_resistance ARO:3003551 emeA A multidrug efflux pump from Enterococcus faecalis. There exist efflux activity of several antimicrobial agents such as DAPI, Hoechst 33342 and acriflavine. Efflux of DAPI via EmeA was strongly inhibited by reserpine. PMID:12576692 emeA FusB encodes a 2-domain zinc-binding protein that binds the ribosomal translocase EF-G, causing it to dissociate from the ribosome. This action increases the ribosomal turnover rate and confers resistance to fusidic acid. This protein is considered a FusB-type protein. fusB antibiotic_resistance ARO:3003552 fusB FusB encodes a 2-domain zinc-binding protein that binds the ribosomal translocase EF-G, causing it to dissociate from the ribosome. This action increases the ribosomal turnover rate and confers resistance to fusidic acid. This protein is considered a FusB-type protein. PMID:16390458 PMID:22308410 fusB CEPS is a typical class C cephalosporinase found in Aeromonas sobria, first isolated from strain 163a. CepS antibiotic_resistance ARO:3003553 CepS CEPS is a typical class C cephalosporinase found in Aeromonas sobria, first isolated from strain 163a. PMID:11062187 CepS Major facilitator superfamily transporter. Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients. tcmA antibiotic_resistance ARO:3003554 tcmA Major facilitator superfamily transporter. Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients. PMID:1592819 tcmA This family of sublcass B1 beta-lactamases were discovered in species of the Shewanella genus. antibiotic_resistance ARO:3003555 SHW beta-lactamase This family of sublcass B1 beta-lactamases were discovered in species of the Shewanella genus. PMID:15772146 This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties. SLB-1 antibiotic_resistance ARO:3003556 SLB-1 This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties. PMID:15772146 SLB-1 This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties. SFB-1 antibiotic_resistance ARO:3003557 SFB-1 This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties. PMID:15772146 SFB-1 Class A beta-lactamase found in Yersinia enterocolitica biovar 1A. Yent_y56 antibiotic_resistance ARO:3003558 y56 beta-lactamase Class A beta-lactamase found in Yersinia enterocolitica biovar 1A. PMID:16553870 Yent_y56 A beta-lactamase found in Bacteroides fragilis producing either low or high levels of the endogenous cephalosporinase activity. cepA antibiotic_resistance ARO:3003559 cepA A beta-lactamase found in Bacteroides fragilis producing either low or high levels of the endogenous cephalosporinase activity. PMID:7517394 cepA Sed-1 is a chromosomal-encoded class A beta-lactamase identified in Citrobacter sedlakii. Sed-1 antibiotic_resistance ARO:3003561 Sed-1 Sed-1 is a chromosomal-encoded class A beta-lactamase identified in Citrobacter sedlakii. PMID:11451687 Sed-1 Class A beta-lactamase found in Mycolicibacterium fortuitum. blaF antibiotic_resistance ARO:3003562 blaF Class A beta-lactamase found in Mycolicibacterium fortuitum. PMID:8065266 blaF RCP is a class A beta-lactamase found in Rhodopseudomonas capsulata. RCP-1 antibiotic_resistance ARO:3003563 RCP-1 RCP is a class A beta-lactamase found in Rhodopseudomonas capsulata. PMID:2788410 RCP-1 Class A beta-lactamase found in Streptomyces albus G. ALBUS EXO-1 antibiotic_resistance ARO:3003564 EXO-1 Class A beta-lactamase found in Streptomyces albus G. PMID:1540134 EXO-1 Class A beta-lactamase found in Actinomadura R39. R39 antibiotic_resistance ARO:3003565 R39 Class A beta-lactamase found in Actinomadura R39. PMID:2515104 R39 Magainins A are antimicrobial peptides produced by amphibians as part of their innate immune system. pubchem.compound:16132424 antibiotic_resistance ARO:3003567 magainin A Magainins A are antimicrobial peptides produced by amphibians as part of their innate immune system. PMID:2285300 Magainin B is is a synthetic analog of magainin 1, an antimicrobial peptide. pubchem.compound:16131332 antibiotic_resistance ARO:3003568 Magainin B Magainin B is is a synthetic analog of magainin 1, an antimicrobial peptide. PMID:2285300 Magainin G is is a synthetic analog of magainin 1, an antimicrobial peptide. It differs from magainin B by the addition of an beta-alanine at the N terminal. pubchem.compound:16132425 antibiotic_resistance ARO:3003569 Magainin G Magainin G is is a synthetic analog of magainin 1, an antimicrobial peptide. It differs from magainin B by the addition of an beta-alanine at the N terminal. PMID:2285300 Magainin H is is a synthetic analog of magainin 1, an antimicrobial peptide. It differs from magainin B with the substitution of D-alanine instead of L-alanine. pubchem.compound:16132431 antibiotic_resistance ARO:3003570 Magainin H Magainin H is is a synthetic analog of magainin 1, an antimicrobial peptide. It differs from magainin B with the substitution of D-alanine instead of L-alanine. PMID:2285300 Magainin1 is an antimicrobial peptides produced by amphibians as part of their innate immune system. It is derived from the Xenopus laevis. pubchem.compound:16132169 antibiotic_resistance ARO:3003571 magainin 1 Magainin1 is an antimicrobial peptides produced by amphibians as part of their innate immune system. It is derived from the Xenopus laevis. PMID:3277183 Magainin 2 is an antimicrobial peptides produced from Xenopus laevis skin. It induce osmotic lysis of bacteria. pubchem.compound:16130189 antibiotic_resistance ARO:3003572 magainin 2 Magainin 2 is an antimicrobial peptides produced from Xenopus laevis skin. It induce osmotic lysis of bacteria. PMID:3277183 The LpxA gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. LpxA antibiotic_resistance ARO:3003573 LpxA The LpxA gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. PMID:20855724 PMID:24189257 LpxA The LpxC gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. LpxC antibiotic_resistance ARO:3003574 LpxC The LpxC gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. PMID:20855724 PMID:24189257 LpxC The LpxD gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. LpxD antibiotic_resistance ARO:3003575 LpxD The LpxD gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. PMID:20855724 PMID:24189257 LpxD PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine, resulting in a less negative cell membrane and decreased binding of polymyxin B. PmrC eptA antibiotic_resistance ARO:3003576 eptA PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine, resulting in a less negative cell membrane and decreased binding of polymyxin B. PMID:15205413 eptA PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. ECK2023 JW2010 pagA pmrE udg ugd yefA antibiotic_resistance ARO:3003577 ugd PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. PMID:15205413 PMID:9570402 ugd PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PmrF arnC antibiotic_resistance ARO:3003578 PmrF PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PMID:9570402 PmrF BasRS is a two-component regulatory system. BasR is phosphorylated by BasS at high[Fe3+] levels. The BasRS system regulates the expression of pmrE, pmrF and pmrC, leading to antibiotic resistance. pmrAB antibiotic_resistance ARO:3003579 basRS BasRS is a two-component regulatory system. BasR is phosphorylated by BasS at high[Fe3+] levels. The BasRS system regulates the expression of pmrE, pmrF and pmrC, leading to antibiotic resistance. PMID:24412662 Genes involved in alteration of the cell wall overall charge, leading to antimicrobial resistance due to reduced binding. antibiotic_resistance ARO:3003580 gene altering cell wall charge These genes are involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. Mutation by absence or insertion of ISAba11 sequence is a known cause of resistance in Acinetobacter baumannii▿. antibiotic_resistance ARO:3003581 Acinetobacter mutant Lpx gene conferring resistance to colistin These genes are involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. Mutation by absence or insertion of ISAba11 sequence is a known cause of resistance in Acinetobacter baumannii▿. PMID:21402838 PMID:24189257 Response regulator for Lipid A modification genes; two-component system involved in polymyxin resistance that senses high extracellular Fe(2+). basR antibiotic_resistance ARO:3003582 basR Response regulator for Lipid A modification genes; two-component system involved in polymyxin resistance that senses high extracellular Fe(2+). PMID:25006521 basR Histidine protein kinase sensor Lipid A modification gene; part of a two-component system involved in polymyxin resistance that senses high extracellular Fe(2+). basS pmrB antibiotic_resistance ARO:3003583 basS Histidine protein kinase sensor Lipid A modification gene; part of a two-component system involved in polymyxin resistance that senses high extracellular Fe(2+). PMID:14507375 PMID:25006521 basS A mutant phoP activates pmrHFIJKLM expression responsible for L-aminoarabinose synthesis and polymyxin resistance, by way of alteration of negative charge. Kleb_PhoP_CST antibiotic_resistance ARO:3003585 Klebsiella mutant PhoP conferring antibiotic resistance to colistin A mutant phoP activates pmrHFIJKLM expression responsible for L-aminoarabinose synthesis and polymyxin resistance, by way of alteration of negative charge. PMID:25733503 Kleb_PhoP_CST The loss or reduction of the net negative charge within the cell wall of gram negative bacteria is a mechanism of resistance for cationic antimicrobials that depend on the negative charge for binding to the surface. antibiotic_resistance ARO:3003588 charge alteration conferring antibiotic resistance NmcA is a class A serine beta-lactamase isolated from Enterobacter cloacae. NmcA antibiotic_resistance ARO:3003589 NmcA NmcA is a class A serine beta-lactamase isolated from Enterobacter cloacae. PMID:8052644 NmcA From the Lahey list of beta-lactamases, not yet released. SHV-190 antibiotic_resistance ARO:3003590 SHV-190 SHV-190 From the Lahey list of beta-lactamases, not yet released. SHV-191 antibiotic_resistance ARO:3003591 SHV-191 SHV-191 From Lahey's list of beta-lactamase, not yet released. antibiotic_resistance ARO:3003592 TEM-223 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-437 antibiotic_resistance ARO:3003593 OXA-437 OXA-437 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-438 antibiotic_resistance ARO:3003594 OXA-438 OXA-438 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-439 antibiotic_resistance ARO:3003595 OXA-439 OXA-439 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-440 antibiotic_resistance ARO:3003596 OXA-440 OXA-440 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-441 antibiotic_resistance ARO:3003597 OXA-441 OXA-441 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-442 antibiotic_resistance ARO:3003598 OXA-442 OXA-442 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-443 antibiotic_resistance ARO:3003599 OXA-443 OXA-443 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-444 antibiotic_resistance ARO:3003600 OXA-444 OXA-444 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. antibiotic_resistance ARO:3003601 OXA-445 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-446 antibiotic_resistance ARO:3003602 OXA-446 OXA-446 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-447 antibiotic_resistance ARO:3003603 OXA-447 OXA-447 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-448 antibiotic_resistance ARO:3003604 OXA-448 OXA-448 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-449 antibiotic_resistance ARO:3003605 OXA-449 OXA-449 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-450 antibiotic_resistance ARO:3003606 OXA-450 OXA-450 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-451 antibiotic_resistance ARO:3003607 OXA-451 OXA-451 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-452 antibiotic_resistance ARO:3003608 OXA-452 OXA-452 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-453 antibiotic_resistance ARO:3003609 OXA-453 OXA-453 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-454 antibiotic_resistance ARO:3003610 OXA-454 OXA-454 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-455 antibiotic_resistance ARO:3003611 OXA-455 OXA-455 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. antibiotic_resistance ARO:3003612 OXA-456 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-457 antibiotic_resistance ARO:3003613 OXA-457 OXA-457 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-458 antibiotic_resistance ARO:3003614 OXA-458 OXA-458 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-459 antibiotic_resistance ARO:3003615 OXA-459 OXA-459 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-460 antibiotic_resistance ARO:3003616 OXA-460 OXA-460 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-461 antibiotic_resistance ARO:3003617 OXA-461 OXA-461 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. antibiotic_resistance ARO:3003618 OXA-462 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. antibiotic_resistance ARO:3003619 OXA-463 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-464 antibiotic_resistance ARO:3003620 OXA-464 OXA-464 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-465 antibiotic_resistance ARO:3003621 OXA-465 OXA-465 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-466 antibiotic_resistance ARO:3003622 OXA-466 OXA-466 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. antibiotic_resistance ARO:3003623 OXA-467 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. antibiotic_resistance ARO:3003624 OXA-468 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. antibiotic_resistance ARO:3003625 OXA-469 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-470 antibiotic_resistance ARO:3003626 OXA-470 OXA-470 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-471 antibiotic_resistance ARO:3003627 OXA-471 OXA-471 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-472 antibiotic_resistance ARO:3003628 OXA-472 OXA-472 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-473 antibiotic_resistance ARO:3003629 OXA-473 OXA-473 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-474 antibiotic_resistance ARO:3003631 OXA-474 OXA-474 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-475 antibiotic_resistance ARO:3003632 OXA-475 OXA-475 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-476 antibiotic_resistance ARO:3003633 OXA-476 OXA-476 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-477 antibiotic_resistance ARO:3003634 OXA-477 OXA-477 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-478 antibiotic_resistance ARO:3003635 OXA-478 OXA-478 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-479 antibiotic_resistance ARO:3003636 OXA-479 OXA-479 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-480 antibiotic_resistance ARO:3003637 OXA-480 OXA-480 OXA-481 is a carbapenem-hydrolyzing class D beta-lactamase. OXA-481 antibiotic_resistance ARO:3003638 OXA-481 OXA-481 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-482 antibiotic_resistance ARO:3003639 OXA-482 OXA-482 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-483 antibiotic_resistance ARO:3003640 OXA-483 OXA-483 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-484 antibiotic_resistance ARO:3003641 OXA-484 OXA-484 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-485 antibiotic_resistance ARO:3003642 OXA-485 OXA-485 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-486 antibiotic_resistance ARO:3003643 OXA-486 OXA-486 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. antibiotic_resistance ARO:3003644 OXA-487 Assigned by Lahey's list of beta-lactamases, no accessions or other information available. OXA-488 antibiotic_resistance ARO:3003645 OXA-488 OXA-488 Assigned by Lahey's list of beta-lactamase, no other information available. CTX-M-162 antibiotic_resistance ARO:3003646 CTX-M-162 CTX-M-162 Assigned by Lahey's list of beta-lactamase, no other information available. CTX-M-163 antibiotic_resistance ARO:3003647 CTX-M-163 CTX-M-163 Assigned by Lahey's list of beta-lactamase, no other information available. CTX-M-164 antibiotic_resistance ARO:3003648 CTX-M-164 CTX-M-164 Assigned by Lahey's list of beta-lactamase, no other information available. CTX-M-165 antibiotic_resistance ARO:3003649 CTX-M-165 CTX-M-165 Assigned by Lahey's list of beta-lactamase, no other information available. CTX-M-166 antibiotic_resistance ARO:3003650 CTX-M-166 CTX-M-166 From Lahey's list of beta-lactamases, no additional information available. CMY-132 antibiotic_resistance ARO:3003652 CMY-132 CMY-132 From Lahey's list of beta-lactamases, no additional information available. CMY-133 antibiotic_resistance ARO:3003653 CMY-133 CMY-133 CMY-134 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016. CMY-134 antibiotic_resistance ARO:3003654 CMY-134 CMY-134 A class C beta-lactamase from Citrobacter freundii. ACT-38 antibiotic_resistance ARO:3003655 ACT-38 ACT-38 From Lahey's list of beta-lactamases, no additional information available. IMP-49 antibiotic_resistance ARO:3003657 IMP-49 IMP-49 From Lahey's list of beta-lactamases, no additional information available. antibiotic_resistance ARO:3003658 IMP-50 From Lahey's list of beta-lactamases, no additional information available. IMP-51 antibiotic_resistance ARO:3003659 IMP-51 IMP-51 From Lahey's list of beta-lactamases, no additional information available. VIM-44 antibiotic_resistance ARO:3003660 VIM-44 VIM-44 From Lahey's list of beta-lactamases, no additional information available. VIM-45 antibiotic_resistance ARO:3003661 VIM-45 VIM-45 From Lahey's list of beta-lactamases, no additional information available. VIM-46 antibiotic_resistance ARO:3003662 VIM-46 VIM-46 New Delhi metallo-beta-lactamase-15 variant of NDM-1. NDM-15 antibiotic_resistance ARO:3003663 NDM-15 NDM-15 New Delhi class B metallo-beta-lactamase-16a variant of NDM-1. NDM-16 NDM-16a antibiotic_resistance ARO:3003664 NDM-16a NDM-16a NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase. NmcR antibiotic_resistance ARO:3003665 NmcR NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase. PMID:8052644 NmcR Point mutations in the 16S rRNA of bacteria can confer resistance to aminoglycosides. antibiotic_resistance ARO:3003666 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics Point mutations in the 16S rRNA of bacteria can confer resistance to peptide antibiotics. antibiotic_resistance ARO:3003667 16s rRNA with mutation conferring resistance to peptide antibiotics Point mutations in the 16S rRNA of bacteria can confer resistance to polyamine antibiotics. antibiotic_resistance ARO:3003668 16s rRNA with mutation conferring resistance to polyamine antibiotics Point mutations in the bacterial 16S rRNA region shown clinically to confer resistance to tetracycline and tetracycline derivatives (polyketide antibiotics). antibiotic_resistance ARO:3003669 16S rRNA with mutation conferring resistance to tetracycline derivatives PEDO-1 is a subclass B3 metallo-beta lactamase isolated from Pedobacter roseus exhibiting resistance to carbapenems. PEDO-1 antibiotic_resistance ARO:3003670 PEDO-1 PEDO-1 is a subclass B3 metallo-beta lactamase isolated from Pedobacter roseus exhibiting resistance to carbapenems. PMID:26482314 PEDO-1 Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa. pubchem.compound:42613186 ACHN-490 antibiotic_resistance ARO:3003675 plazomicin Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa. PMID:21131322 AAC(6')-Ib' is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in P. aeruginosa and P. fluorescens. AAC(6')-Ib' antibiotic_resistance ARO:3003676 AAC(6')-Ib' AAC(6')-Ib' is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in P. aeruginosa and P. fluorescens. PMID:10720551 PMID:8138142 AAC(6')-Ib' AAC(6')-Iaj is a functional acetyltransferase that modifies the amino groups at the 6' positions of aminoglycosides and contributes to aminoglycoside resistance of P. aeruginosa. AAC(6')-Iaj antibiotic_resistance ARO:3003677 AAC(6')-Iaj AAC(6')-Iaj is a functional acetyltransferase that modifies the amino groups at the 6' positions of aminoglycosides and contributes to aminoglycoside resistance of P. aeruginosa. PMID:23070167 AAC(6')-Iaj TriABC-OpmH is a triclosan-specific efflux pump expressed in the Gram-negative Pseudomonas aeruginosa. TriABC is the only P. aeruginosa resistance nodulation cell division (RND) pump which contains two membrane fusion proteins, TriA and TriB, and both are required for efflux pump function. TriABC associated with OpmH assemble a functional triclosan efflux pump. TriABC-OpmH antibiotic_resistance ARO:3003678 TriABC-OpmH TriABC-OpmH is a triclosan-specific efflux pump expressed in the Gram-negative Pseudomonas aeruginosa. TriABC is the only P. aeruginosa resistance nodulation cell division (RND) pump which contains two membrane fusion proteins, TriA and TriB, and both are required for efflux pump function. TriABC associated with OpmH assemble a functional triclosan efflux pump. PMID:17720796 TriABC-OpmH TriA is a membrane protein that is fused to TriB and both are required for the triclosan efflux pump function of TriABC-OpmH in P. aeruginosa. TriA antibiotic_resistance ARO:3003679 TriA TriA is a membrane protein that is fused to TriB and both are required for the triclosan efflux pump function of TriABC-OpmH in P. aeruginosa. PMID:17720796 TriA TriB is a membrane protein that is fused to TriA and both are required for the triclosan efflux pump function of TriABC-OpmH in P. aeruginosa. TriB antibiotic_resistance ARO:3003680 TriB TriB is a membrane protein that is fused to TriA and both are required for the triclosan efflux pump function of TriABC-OpmH in P. aeruginosa. PMID:17720796 TriB TriC is a resistance nodulation cell division (RND) transporter that is a part of TriABC-OpmH, a triclosan-specific efflux protein. TriC antibiotic_resistance ARO:3003681 TriC TriC is a resistance nodulation cell division (RND) transporter that is a part of TriABC-OpmH, a triclosan-specific efflux protein. PMID:17720796 TriC OpmH is an outer membrane efflux protein required for triclosan-specific efflux pump function. OpmH antibiotic_resistance ARO:3003682 OpmH OpmH is an outer membrane efflux protein required for triclosan-specific efflux pump function. PMID:15855547 PMID:17720796 OpmH Point mutation of Pseudomonas aeruginosa gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. Paer_gyrA_FLO antibiotic_resistance ARO:3003684 Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones Point mutation of Pseudomonas aeruginosa gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. PMID:22821356 PMID:8540700 Paer_gyrA_FLO Point mutation in Pseudomonas aeruginosa parE resulting in sensitivity to fluoroquinolones (ciprofloxacin). In combination with a gyrase mutation (gyrA or gyrB), it confers a high level of resistance to ciprofloxacin. Paer_parE_FLO antibiotic_resistance ARO:3003685 Pseudomonas aeruginosa parE conferring resistance to fluoroquinolones Point mutation in Pseudomonas aeruginosa parE resulting in sensitivity to fluoroquinolones (ciprofloxacin). In combination with a gyrase mutation (gyrA or gyrB), it confers a high level of resistance to ciprofloxacin. PMID:23274661 Paer_parE_FLO oprD is an outer membrane porin which facilitates the uptake of basic amino acids and imipenem in Pseudomonas aeruginosa. Paer_oprD_IPM antibiotic_resistance ARO:3003686 Pseudomonas aeruginosa oprD with mutation conferring resistance to imipenem oprD is an outer membrane porin which facilitates the uptake of basic amino acids and imipenem in Pseudomonas aeruginosa. PMID:12534469 PMID:23045355 PMID:25297323 Paer_oprD_IPM PvrR is a response regulator that controls the conversion between antibiotic-resistant and antibiotic-susceptible forms of Pseudomonas aeruginosa biofilms through porin deletion/gene absence. PvrR antibiotic_resistance ARO:3003688 PvrR PvrR is a response regulator that controls the conversion between antibiotic-resistant and antibiotic-susceptible forms of Pseudomonas aeruginosa biofilms through porin deletion/gene absence. PMID:11961556 PvrR MCR-1 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting reduction in negative charge of the cell membrane. MCR-1 MCR-1.1 antibiotic_resistance ARO:3003689 MCR-1.1 MCR-1 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting reduction in negative charge of the cell membrane. PMID:26603172 MCR-1.1 Sitafloxacin is a fluoroquinolone active against multi-resistant Gram-positive and negative pathogens. Sitafloxacin shows inhibitory activity against DNA gyrase and topoisomerase IV, which blocks bacterial DNA replication, thereby causing double-stranded breaks in the bacterial chromosome. pubchem.compound:461399 Gracevit antibiotic_resistance ARO:3003690 sitafloxacin Sitafloxacin is a fluoroquinolone active against multi-resistant Gram-positive and negative pathogens. Sitafloxacin shows inhibitory activity against DNA gyrase and topoisomerase IV, which blocks bacterial DNA replication, thereby causing double-stranded breaks in the bacterial chromosome. PMID:21504249 MexJK-OpmH is a triclosan efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexJ is the membrane fusion protein, MexK is the inner membrane resistance-nodulation-cell division (RND) transporter, and OpmH is the outer membrane efflux protein. MexJK is constitutively expressed in mexL mutants. MexJK-OpmH antibiotic_resistance ARO:3003691 MexJK-OpmH MexJK-OpmH is a triclosan efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexJ is the membrane fusion protein, MexK is the inner membrane resistance-nodulation-cell division (RND) transporter, and OpmH is the outer membrane efflux protein. MexJK is constitutively expressed in mexL mutants. PMID:12193619 PMID:15855547 MexJK-OpmH MexJ is the membrane fusion protein of the MexJK multidrug efflux protein. MexJ antibiotic_resistance ARO:3003692 MexJ MexJ is the membrane fusion protein of the MexJK multidrug efflux protein. PMID:12193619 MexJ MexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein. MexK antibiotic_resistance ARO:3003693 MexK MexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein. PMID:12193619 MexK MexJK-OprM is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexJ is the membrane fusion protein, MexK is the inner membrane resistance-nodulation-cell division (RND) transporter, and OprM is the outer membrane factor protein. MexJK-OprM antibiotic_resistance ARO:3003694 MexJK-OprM MexJK-OprM is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexJ is the membrane fusion protein, MexK is the inner membrane resistance-nodulation-cell division (RND) transporter, and OprM is the outer membrane factor protein. PMID:15855547 MexJK-OprM MexPQ-OpmE multidrug efflux pump expressed in Pseudomonas aeruginosa. MexP is the membrane fusion protein; MexQ is the inner membrane transporter; and OpmE is the outer membrane channel. MexPQ-OpmE antibiotic_resistance ARO:3003697 MexPQ-OpmE MexPQ-OpmE multidrug efflux pump expressed in Pseudomonas aeruginosa. MexP is the membrane fusion protein; MexQ is the inner membrane transporter; and OpmE is the outer membrane channel. PMID:16301811 MexPQ-OpmE MexP is the membrane fusion protein of the MexPQ-OpmE multidrug efflux complex. mexP antibiotic_resistance ARO:3003698 mexP MexP is the membrane fusion protein of the MexPQ-OpmE multidrug efflux complex. PMID:16301811 mexP MexQ is the inner membrane transporter of the multidrug efflux pump MexPQ-OpmE. mexQ antibiotic_resistance ARO:3003699 mexQ MexQ is the inner membrane transporter of the multidrug efflux pump MexPQ-OpmE. PMID:16301811 mexQ opmE is an outer membrane factor protein that is part of the multidrug efflux pump MexPQ-OpmE. opmE antibiotic_resistance ARO:3003700 opmE opmE is an outer membrane factor protein that is part of the multidrug efflux pump MexPQ-OpmE. PMID:16301811 opmE Rokitamycin is a macrolide antibiotic. Synthesized from strains of Streptomyces kitasatoensis. pubchem.compound:5282211 antibiotic_resistance ARO:3003701 rokitamycin Rokitamycin is a macrolide antibiotic. Synthesized from strains of Streptomyces kitasatoensis. PMID:1779258 Point mutation in Pseudomonas aeruginosa parC resulting in fluoroquinolone resistance also requiring a gyrA mutation. Paer_ParC_FLO antibiotic_resistance ARO:3003702 Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolones Point mutation in Pseudomonas aeruginosa parC resulting in fluoroquinolone resistance also requiring a gyrA mutation. PMID:11451683 PMID:22821356 Paer_ParC_FLO MexMN-OprM is a multidrug efflux pump expressed in Pseudomonas aeruginosa. MexM is the membrane fusion protein; MexN is the inner membrane transporter; and OprM is the outer membrane channel. MexMN-OprM antibiotic_resistance ARO:3003703 MexMN-OprM MexMN-OprM is a multidrug efflux pump expressed in Pseudomonas aeruginosa. MexM is the membrane fusion protein; MexN is the inner membrane transporter; and OprM is the outer membrane channel. PMID:19713238 MexMN-OprM mexM is the membrane fusion protein of the MexMN-OprM multidrug efflux complex. mexM antibiotic_resistance ARO:3003704 mexM mexM is the membrane fusion protein of the MexMN-OprM multidrug efflux complex. PMID:19713238 mexM MexN is the inner membrane transporter of the MexMN-OprM multidrug efflux complex. mexN antibiotic_resistance ARO:3003705 mexN MexN is the inner membrane transporter of the MexMN-OprM multidrug efflux complex. PMID:19713238 mexN Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur. antibiotic_resistance ARO:3003706 penem Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur. PMID:14620395 PMID:3043117 Faropenem is an orally active beta-lactam antibiotic belonging to the penem group. pubchem.compound:65894 antibiotic_resistance ARO:3003707 faropenem Faropenem is an orally active beta-lactam antibiotic belonging to the penem group. PMID:12615878 Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial. It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity. pubchem.compound:72015 antibiotic_resistance ARO:3003708 panipenem Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial. It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity. PMID:12678575 MexZ is a transcriptional regulator that downregulates the mexXY multidrug transporter operon, which confers to aminoglycoside resistance on Pseudomonas aeruginosa. MexZ antibiotic_resistance ARO:3003709 MexZ MexZ is a transcriptional regulator that downregulates the mexXY multidrug transporter operon, which confers to aminoglycoside resistance on Pseudomonas aeruginosa. PMID:15336398 MexZ MexL is a specific repressor of mexJK transcription and autoregulates its own expression. MexL antibiotic_resistance ARO:3003710 MexL MexL is a specific repressor of mexJK transcription and autoregulates its own expression. PMID:15855505 MexL VEB-1b is a beta-lactamase that is found in Pseudomonas aeruginosa. VEB-1b antibiotic_resistance ARO:3003712 VEB-1b VEB-1b is a beta-lactamase that is found in Pseudomonas aeruginosa. PMID:11384532 VEB-1b VCC-1 is a Class A carbapenemase isolated from Vibrio cholerae and exhibits resistance to penicillins, carbapenems and monobactam antibiotics. VCC-1 antibiotic_resistance ARO:3003713 VCC-1 VCC-1 is a Class A carbapenemase isolated from Vibrio cholerae and exhibits resistance to penicillins, carbapenems and monobactam antibiotics. PMID:26824956 VCC-1 PEDO-2 is a subclass B3 metallo-beta lactamase isolated from Pedobacter borealis exhibiting carbapenem resistance. PEDO-2 antibiotic_resistance ARO:3003714 PEDO-2 PEDO-2 is a subclass B3 metallo-beta lactamase isolated from Pedobacter borealis exhibiting carbapenem resistance. PMID:26482314 PEDO-2 PEDO-3 is a class B1 metallo-beta lactamase isolated from Pedobacter kyungheensis exhibiting resistance to carbapenems. PEDO-3 antibiotic_resistance ARO:3003715 PEDO-3 PEDO-3 is a class B1 metallo-beta lactamase isolated from Pedobacter kyungheensis exhibiting resistance to carbapenems. PMID:26482314 PEDO-3 CPS-1 is a subclass B3 metallo-beta lactamase isolated from Chyseobacterium piscium exhibiting carbapenem resistance. B3CSP-1 CPS-1 antibiotic_resistance ARO:3003716 CPS-1 CPS-1 is a subclass B3 metallo-beta lactamase isolated from Chyseobacterium piscium exhibiting carbapenem resistance. PMID:26666948 CPS-1 ESP-1 is a subclass B3 metallo-beta lactamase isolated from Epilithonimonas tenax conferring resistance to carbapenems. ESP-1 antibiotic_resistance ARO:3003717 ESP-1 ESP-1 is a subclass B3 metallo-beta lactamase isolated from Epilithonimonas tenax conferring resistance to carbapenems. PMID:26482314 ESP-1 MSI-1 is a subclass B3 metallo-beta lactamase isolated from Massilia oculi conferring resistance to carbapenems. MSI-1 antibiotic_resistance ARO:3003718 MSI-1 MSI-1 is a subclass B3 metallo-beta lactamase isolated from Massilia oculi conferring resistance to carbapenems. PMID:26482314 MSI-1 MSI-OXA is an OXA-85-like class D beta lactamase isolated from Massilia oculi. MSI-OXA antibiotic_resistance ARO:3003719 MSI-OXA MSI-OXA is an OXA-85-like class D beta lactamase isolated from Massilia oculi. PMID:26482314 MSI-OXA SPG-1 is a subclass B3 metallo-beta lactamase isolated from Sphingomonas sp. SPG-1 antibiotic_resistance ARO:3003720 SPG-1 SPG-1 is a subclass B3 metallo-beta lactamase isolated from Sphingomonas sp. PMID:26482314 SPG-1 This inducible cluster confers high resistance to vancomycin and intermediate resistance to teicoplanin. It achieves this through peptidoglycan restructuring with its VanA ligase homologue, VanI, causing the precursurs to end in D-Ala-D-Lac. The cluster uniquely contains murF, the final enzyme in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. The VanI gene cluster has been found in chromosomal DNA. Gene orientation: vanSRIWK-murFvanX. vanI_cluster antibiotic_resistance ARO:3003722 glycopeptide resistance gene cluster VanI This inducible cluster confers high resistance to vancomycin and intermediate resistance to teicoplanin. It achieves this through peptidoglycan restructuring with its VanA ligase homologue, VanI, causing the precursurs to end in D-Ala-D-Lac. The cluster uniquely contains murF, the final enzyme in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. The VanI gene cluster has been found in chromosomal DNA. Gene orientation: vanSRIWK-murFvanX. PMID:16513756 PMID:19414574 PMID:25042042 vanI_cluster VanI is a D-Ala-D-Lac ligase that reduces vancomycin binding affinity, helping to confer vancomycin resistance as part of the VanI resistance gene cluster in Desulfitobacterium spp. and Desulfosporosinus spp. vanI antibiotic_resistance ARO:3003723 vanI VanI is a D-Ala-D-Lac ligase that reduces vancomycin binding affinity, helping to confer vancomycin resistance as part of the VanI resistance gene cluster in Desulfitobacterium spp. and Desulfosporosinus spp. PMID:19414574 PMID:25042042 vanI Also known as vanWI, is a vanW variant found in the vanI gene cluster. vanW-I vanWI vanW_in_vanI_cl antibiotic_resistance ARO:3003724 vanW gene in vanI cluster Also known as vanWI, is a vanW variant found in the vanI gene cluster. PMID:16513756 PMID:19414574 vanW_in_vanI_cl Also known as vanXI, is a vanX variant found in the vanI glycopeptide resistance gene cluster. It is a D-Ala-D-Ala dipeptidase. vanX-I vanXI vanX_in_vanI_cl antibiotic_resistance ARO:3003725 vanX gene in vanI cluster Also known as vanXI, is a vanX variant found in the vanI glycopeptide resistance gene cluster. It is a D-Ala-D-Ala dipeptidase. PMID:25042042 vanX_in_vanI_cl Also known as vanSI, is a vanS variant found in the vanI gene cluster; it is a histidine kinase. vanS-I vanSI vanS_in_vanI_cl antibiotic_resistance ARO:3003726 vanS gene in vanI cluster Also known as vanSI, is a vanS variant found in the vanI gene cluster; it is a histidine kinase. PMID:16513756 PMID:19414574 vanS_in_vanI_cl Also known as vanKI, is a peptidoglycan bridge formation protein also known as FemAB that is part of the vanI glycopeptide resistance gene cluster. vanK-I vanKI vanK_in_vanI_cl antibiotic_resistance ARO:3003727 vanK gene in vanI cluster Also known as vanKI, is a peptidoglycan bridge formation protein also known as FemAB that is part of the vanI glycopeptide resistance gene cluster. PMID:19414574 PMID:25042042 vanK_in_vanI_cl Also known as vanRI, is the regulatory transcriptional activator in the vanSR regulator within the vanI glycopeptide resistance gene cluster. vanR-I vanRI vanR_in_vanI_cl antibiotic_resistance ARO:3003728 vanR gene in vanI cluster Also known as vanRI, is the regulatory transcriptional activator in the vanSR regulator within the vanI glycopeptide resistance gene cluster. PMID:19414574 PMID:25042042 vanR_in_vanI_cl Point mutations to the isoleucyl-tRNA synthetase (ileS) in Staphylococcus aureus that confer resistance to mupirocin. Saur_ileS_MUP antibiotic_resistance ARO:3003729 Staphylococcus aureus ileS with mutation conferring resistance to mupirocin Point mutations to the isoleucyl-tRNA synthetase (ileS) in Staphylococcus aureus that confer resistance to mupirocin. PMID:11796355 Saur_ileS_MUP Bifidobacteria have an intrinsically resistant form of ileS (isoleucyl-tRNA synthetase) that confers resistance to mupirocin. Bbif_ileS_MUP antibiotic_resistance ARO:3003730 Bifidobacterium bifidum ileS conferring resistance to mupirocin Bifidobacteria have an intrinsically resistant form of ileS (isoleucyl-tRNA synthetase) that confers resistance to mupirocin. PMID:21421794 Bbif_ileS_MUP A specific fusidic acid resistance gene conferring intrinsic resistance in the bacteria Staphylococcus saprophyticus. FusD behaves by causing dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. It is considered a FusB-type protein. fusD antibiotic_resistance ARO:3003731 fusD A specific fusidic acid resistance gene conferring intrinsic resistance in the bacteria Staphylococcus saprophyticus. FusD behaves by causing dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. It is considered a FusB-type protein. PMID:17325218 fusD FusC is a fusidic acid resistance gene enabling ribosomal translocase EF-G dissociation from the ribosome that has been detected in Staphylococcus aureus and Staphylococcus intermedius. Its mechanism is believed to be similar to fusB due to its high level of sequence homology. It is considered a FusB-type protein. fusC antibiotic_resistance ARO:3003733 fusC FusC is a fusidic acid resistance gene enabling ribosomal translocase EF-G dissociation from the ribosome that has been detected in Staphylococcus aureus and Staphylococcus intermedius. Its mechanism is believed to be similar to fusB due to its high level of sequence homology. It is considered a FusB-type protein. PMID:17325218 fusC Antibiotic resistant fusA is caused by mutations to the elongation factor G (EF-G) and confers resistance to fusidic acid. antibiotic_resistance ARO:3003734 antibiotic resistant fusA Antibiotic resistant fusA is caused by mutations to the elongation factor G (EF-G) and confers resistance to fusidic acid. PMID:19289529 The mutations to this gene are involved in altering the translation elongation factor G (EF-G) in association with the ribosome to prevent fusidic acid from binding EF-G and preventing translation. Saur_fusA_FA antibiotic_resistance ARO:3003735 Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid The mutations to this gene are involved in altering the translation elongation factor G (EF-G) in association with the ribosome to prevent fusidic acid from binding EF-G and preventing translation. PMID:11309125 PMID:12519196 PMID:19289529 PMID:20430787 PMID:20566766 PMID:33353175 Saur_fusA_FA Antibiotic resistant fusE is caused by mutations in a region of the rplF gene encoding riboprotein L6, and confers resistance to fusidic acid. antibiotic_resistance ARO:3003736 antibiotic resistant fusE Antibiotic resistant fusE is caused by mutations in a region of the rplF gene encoding riboprotein L6, and confers resistance to fusidic acid. PMID:19289529 The mutations to the rplF gene encoding riboprotein L6 have been shown to cause fusidic acid resistance, demonstrating a potential secondary site of action of the antibiotic that is blocked through these mutations. Several types of mutations have been identified that cause resistance, including SNPs, frameshift mutations and early stop codons. 50S ribosomal subunit protein L6 Saur_fusE_FA rplF antibiotic_resistance ARO:3003737 Staphylococcus aureus fusE with mutation conferring resistance to fusidic acid The mutations to the rplF gene encoding riboprotein L6 have been shown to cause fusidic acid resistance, demonstrating a potential secondary site of action of the antibiotic that is blocked through these mutations. Several types of mutations have been identified that cause resistance, including SNPs, frameshift mutations and early stop codons. PMID:17923494 PMID:19289529 PMID:20430787 PMID:20729356 Saur_fusE_FA mphE is a macrolide phosphotransferase and resistance gene identified on a plasmid, pRSB105. mphE antibiotic_resistance ARO:3003741 mphE mphE is a macrolide phosphotransferase and resistance gene identified on a plasmid, pRSB105. PMID:17261525 PMID:29317655 mphE The mphG gene encodes a macrolide 2'-phosphotransferase found in Photobacterium damselae sharing sequence similarity to mphA in E. coli. mphG antibiotic_resistance ARO:3003742 mphG The mphG gene encodes a macrolide 2'-phosphotransferase found in Photobacterium damselae sharing sequence similarity to mphA in E. coli. PMID:25765542 PMID:29317655 mphG vatF is a streptogramin A acetyl transferase gene isolated from the chromosome of Yersinia enterocolitica. vatF antibiotic_resistance ARO:3003744 vatF vatF is a streptogramin A acetyl transferase gene isolated from the chromosome of Yersinia enterocolitica. PMID:10722489 vatF mef(C) is a macrolide efflux gene isolated from a plasmid in Photobacterium damselae. mef(C) mefC antibiotic_resistance ARO:3003745 mef(C) mef(C) is a macrolide efflux gene isolated from a plasmid in Photobacterium damselae. PMID:22446310 mef(C) OptrA is a member of the ABC-F protein subfamily that confers resistance to oxazolidinones. The gene encoding the protein was originally isolated from a plasmid in Enterococcus faecalis and Enterococcus faecium. optrA antibiotic_resistance ARO:3003746 optrA OptrA is a member of the ABC-F protein subfamily that confers resistance to oxazolidinones. The gene encoding the protein was originally isolated from a plasmid in Enterococcus faecalis and Enterococcus faecium. PMID:25977397 optrA oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion. oleC antibiotic_resistance ARO:3003748 oleC oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion. PMID:8326867 oleC salA is an ABC-F subfamily protein gene isolated from the chromosome of Mammaliicoccus sciuri conferring resistance to lincosamides and streptogramins. sal(A) salA antibiotic_resistance ARO:3003749 salA salA is an ABC-F subfamily protein gene isolated from the chromosome of Mammaliicoccus sciuri conferring resistance to lincosamides and streptogramins. PMID:24687494 PMID:25891423 salA nfsA encodes the major oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA. Ecol_nfsA_NIT antibiotic_resistance ARO:3003751 Escherichia coli nfsA mutations conferring resistance to nitrofurantoin nfsA encodes the major oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA. PMID:15684426 PMID:18544599 PMID:26552976 Ecol_nfsA_NIT The nfsA-encoded nitroreductase is the major oxygen-insensitive nitroreductase present in E. coli. NfsA uses only NADPH and has broad electron acceptor specificity. Mutations in nfsA cause resistance to nitrofurazone and furazolidone. Resistance to nitrofurantoin via mutation of nfsA reduces the fitness of clinical isolates of E. coli. antibiotic_resistance ARO:3003754 antibiotic resistant nfsA The nfsA-encoded nitroreductase is the major oxygen-insensitive nitroreductase present in E. coli. NfsA uses only NADPH and has broad electron acceptor specificity. Mutations in nfsA cause resistance to nitrofurazone and furazolidone. Resistance to nitrofurantoin via mutation of nfsA reduces the fitness of clinical isolates of E. coli. PMID:15684426 PMID:18544599 PMID:338576 PMID:9791100 The nsfB gene encodes a minor oxygen-insensitive nitroreductase. NfsB reduces a broad range of nitroaromatic compounds including the antibiotics nitrofurazone and nitrofurantoin. NfsB is a flavin mononucleotide (FMN)-containing protein and uses both NADH and NADPH as a source of reducing equivalents. Mutations in nfsB lead to increased resistance to nitrofurazone and furazolidone in an nfsA mutant background. antibiotic_resistance ARO:3003755 Antibiotic resistant nfsB The nsfB gene encodes a minor oxygen-insensitive nitroreductase. NfsB reduces a broad range of nitroaromatic compounds including the antibiotics nitrofurazone and nitrofurantoin. NfsB is a flavin mononucleotide (FMN)-containing protein and uses both NADH and NADPH as a source of reducing equivalents. Mutations in nfsB lead to increased resistance to nitrofurazone and furazolidone in an nfsA mutant background. PMID:338576 PMID:7011517 PMID:8947835 PMID:9791100 nfsB encodes the minor oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA, while the increased resistance associated with second step mutants is a consequence of nfsB mutation. Ecol_nfsB_NIT antibiotic_resistance ARO:3003756 Escherichia coli nfsB with mutation conferring resistance to nitrofurantoin nfsB encodes the minor oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA, while the increased resistance associated with second step mutants is a consequence of nfsB mutation. PMID:18544599 PMID:26552976 PMID:9791100 Ecol_nfsB_NIT Cardiolipin synthase (cls) is an inner membrane protein involved in membrane synthesis and phosopholipid metabolism, with mutations to the gene being capable of conferring daptomycin resistance. Efae_cls_DAP antibiotic_resistance ARO:3003760 Enterococcus faecalis cls with mutation conferring resistance to daptomycin Cardiolipin synthase (cls) is an inner membrane protein involved in membrane synthesis and phosopholipid metabolism, with mutations to the gene being capable of conferring daptomycin resistance. PMID:23114777 PMID:23959318 PMID:24957825 Efae_cls_DAP eatAv is a mutated form of the wildtype eatA ABC-F subfamily protein isolated from Enterococcus faecium conferring resistance to lincosamides, streptogramin A's and pleuromutilins (LSaP phenotype). eatAv antibiotic_resistance ARO:3003761 eatAv eatAv is a mutated form of the wildtype eatA ABC-F subfamily protein isolated from Enterococcus faecium conferring resistance to lincosamides, streptogramin A's and pleuromutilins (LSaP phenotype). PMID:22366422 PMID:23836170 eatAv lnuE encodes a lincosamide resistance gene isolated from Streptococcus suis that was truncated by an ISEnfa5-cfr-ISEnfa5 segment insertion. It shares the closest sequence similarity to lnuA. linE lnuE antibiotic_resistance ARO:3003762 lnuE lnuE encodes a lincosamide resistance gene isolated from Streptococcus suis that was truncated by an ISEnfa5-cfr-ISEnfa5 segment insertion. It shares the closest sequence similarity to lnuA. PMID:24366733 lnuE Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin). antibiotic_resistance ARO:3003764 resistance by absence mphM is a chromosomally-encoded macrolide phosphotransferases that inactivate 14-, 15- and 16-membered macrolides. mphM antibiotic_resistance ARO:3003767 mphM mphM is a chromosomally-encoded macrolide phosphotransferases that inactivate 14-, 15- and 16-membered macrolides. PMID:25059531 PMID:29317655 mphM Deletion of gene or gene product results in resistance. For example, deletion of a porin gene blocks drug from entering the cell. antibiotic_resistance ARO:3003768 gene conferring resistance via absence MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. A point mutation in the putative mprF synthase domain is associated with enhanced expression, increased synthesis and reduced daptomycin surface binding. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Saur_mprF antibiotic_resistance ARO:3003769 Staphylococcus aureus mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. A point mutation in the putative mprF synthase domain is associated with enhanced expression, increased synthesis and reduced daptomycin surface binding. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. PMID:14769468 PMID:19915718 PMID:20498310 Saur_mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Lmon_mprF antibiotic_resistance ARO:3003770 Listeria monocytogenes mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. PMID:17042784 PMID:19915718 Lmon_mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Bsui_mprF antibiotic_resistance ARO:3003772 Brucella suis mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. PMID:19915718 Bsui_mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Cper_mprF antibiotic_resistance ARO:3003773 Clostridium perfringens mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. PMID:19915718 Cper_mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Saga_mprF antibiotic_resistance ARO:3003774 Streptococcus agalactiae mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. PMID:19915718 Saga_mprF murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations such as Asp369Asn and Leu370Ile confers fosfomycin resistance. Extensive evidence has shown the significance of C115 mutations in conferring fosfomycin resistance since this residue represents a primary binding site for the antibiotic across many species. Ecol_murA_FOF antibiotic_resistance ARO:3003775 Escherichia coli murA with mutation conferring resistance to fosfomycin murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations such as Asp369Asn and Leu370Ile confers fosfomycin resistance. Extensive evidence has shown the significance of C115 mutations in conferring fosfomycin resistance since this residue represents a primary binding site for the antibiotic across many species. PMID:20071153 PMID:23143172 PMID:8281938 PMID:8664284 Ecol_murA_FOF murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance. Saur_murA_FOF antibiotic_resistance ARO:3003776 Staphylococcus aureus murA with mutation conferring resistance to fosfomycin murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance. PMID:26793179 Saur_murA_FOF murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Mutations to the murA enzyme confers resistance to the antibiotic. Bbur_mur_FOF antibiotic_resistance ARO:3003777 Borreliella burgdorferi murA with mutation conferring resistance to fosfomycin murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Mutations to the murA enzyme confers resistance to the antibiotic. PMID:21294548 Bbur_mur_FOF Mutations in the Mycolicibacterium smegmatis ndh gene that results in increased resistance to isoniazid. Msme_ndh_INH antibiotic_resistance ARO:3003778 Mycolicibacterium smegmatis ndh with mutation conferring resistance to isoniazid Mutations in the Mycolicibacterium smegmatis ndh gene that results in increased resistance to isoniazid. PMID:15673755 Msme_ndh_INH Mutations in the Mycobacterium tuberculosis variant bovis ndh gene that results in increased resistance to isoniazid. Mbov_ndh_INH antibiotic_resistance ARO:3003779 Mycobacterium tuberculosis variant bovis ndh with mutation conferring resistance to isoniazid Mutations in the Mycobacterium tuberculosis variant bovis ndh gene that results in increased resistance to isoniazid. PMID:15673755 Mbov_ndh_INH A heterocyclic antibiotic that targets mutant gyrA (type II topoisomerase) containing an S84L substitution, counteracting acquired quinolone resistance. It is effective against quinolone-resistant Gram-positive bacteria including S. aureus and E. faecalis. Due to its ability to counteract quinolone resistance by targeting the mutant form of the gyrA protein, it is classified as a reverse antibiotic (RA). pubchem.compound:169159 antibiotic_resistance ARO:3003780 nybomycin A heterocyclic antibiotic that targets mutant gyrA (type II topoisomerase) containing an S84L substitution, counteracting acquired quinolone resistance. It is effective against quinolone-resistant Gram-positive bacteria including S. aureus and E. faecalis. Due to its ability to counteract quinolone resistance by targeting the mutant form of the gyrA protein, it is classified as a reverse antibiotic (RA). PMID:16589716 PMID:22534508 Mycobacterium tuberculosis murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 117 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance. Mtub_murA_FOF antibiotic_resistance ARO:3003784 Mycobacterium tuberculosis intrinsic murA conferring resistance to fosfomycin Mycobacterium tuberculosis murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 117 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance. PMID:10589726 PMID:22404577 Mtub_murA_FOF Chlamydia murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 119 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance. Ctra_murA_FOF antibiotic_resistance ARO:3003785 Chlamydia trachomatis intrinsic murA conferring resistance to fosfomycin Chlamydia murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 119 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance. PMID:12562791 Ctra_murA_FOF Inherent parC resistance to fluoroquinolone from an antibiotic producer. The presence of these genes confers self-resistance to the antibiotic it produces. antibiotic_resistance ARO:3003786 fluoroquinolone self resistant parC Inherent ParY resistant to aminocoumarin from an antibiotic producer. The presence of these genes confers self resistance to the antibiotic it produces. antibiotic_resistance ARO:3003787 aminocoumarin self resistant parY Point mutations that occur within the Bacillus subtilis pgsA gene resulting in resistance to daptomycin. Bsub_pgsA_DAP antibiotic_resistance ARO:3003788 Bacillus subtilis pgsA with mutation conferring resistance to daptomycin Point mutations that occur within the Bacillus subtilis pgsA gene resulting in resistance to daptomycin. PMID:12044378 PMID:21709092 Bsub_pgsA_DAP Campylobacter jejuni is a major bacterial infectious agent associated with gastroenteritis. Quinolone resistance is reportedly conferred by a single C-257-T nucleotide substitution in the gyrA gene. Cjej_gyrA_FLO antibiotic_resistance ARO:3003789 Campylobacter jejuni gyrA conferring resistance to fluoroquinolones Campylobacter jejuni is a major bacterial infectious agent associated with gastroenteritis. Quinolone resistance is reportedly conferred by a single C-257-T nucleotide substitution in the gyrA gene. PMID:26658311 Cjej_gyrA_FLO liaF is an accessory protein that acts as a negative regulator of liaRS signal transduction pathway. Mutations confer daptomycin resistance. Efac_liaF_DAP antibiotic_resistance ARO:3003790 Enterococcus faecium liaF mutant conferring daptomycin resistance liaF is an accessory protein that acts as a negative regulator of liaRS signal transduction pathway. Mutations confer daptomycin resistance. PMID:15793168 PMID:21899450 Efac_liaF_DAP liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. Efae_liaS_DAP antibiotic_resistance ARO:3003791 Enterococcus faecalis liaS mutant conferring daptomycin resistance liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. PMID:21899450 Efae_liaS_DAP liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. Efae_liaR_DAP antibiotic_resistance ARO:3003792 Enterococcus faecalis liaR mutant conferring daptomycin resistance liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. PMID:23959318 Efae_liaR_DAP Plasmid-mediated SPM metallo-beta-lactamase conferring resistance to carbapenem. Originally isolated from Pseudomonas aeruginosa. Responsible for carbapenem-resistant Pseudomonas aeruginosa (CRPA) outbreaks in Brazil. SPM-1 antibiotic_resistance ARO:3003793 SPM-1 Plasmid-mediated SPM metallo-beta-lactamase conferring resistance to carbapenem. Originally isolated from Pseudomonas aeruginosa. Responsible for carbapenem-resistant Pseudomonas aeruginosa (CRPA) outbreaks in Brazil. PMID:12407123 PMID:16239284 SPM-1 walK is the histidine kinase sensor of a two-component regulatory system controlling peptidoglycan metabolism through regulation of the expression of most of the peptidoglycan hydrolase genes. Mutations in the gene have been found that confer daptomycin resistance. Saur_walK_DAP vicK yycG antibiotic_resistance ARO:3003794 Staphylococcus aureus walK with mutation conferring resistance to daptomycin walK is the histidine kinase sensor of a two-component regulatory system controlling peptidoglycan metabolism through regulation of the expression of most of the peptidoglycan hydrolase genes. Mutations in the gene have been found that confer daptomycin resistance. PMID:16723576 PMID:23554895 Saur_walK_DAP Mutations to the walK gene, part of a cell wall metabolism 2-component regulatory system, confers resistance to antibiotics, specifically daptomycin. antibiotic_resistance ARO:3003795 daptomycin resistant walK Mutations to the walK gene, part of a cell wall metabolism 2-component regulatory system, confers resistance to antibiotics, specifically daptomycin. PMID:23554895 A class C beta-lactamase found in Acinetobacter baumannii that confers resistance to piperacillin and cefepime. Abau_ampC_BLA antibiotic_resistance ARO:3003796 Acinetobacter baumannii ampC beta-lactamase A class C beta-lactamase found in Acinetobacter baumannii that confers resistance to piperacillin and cefepime. PMID:21304033 Abau_ampC_BLA YybT has phosphodiesterase activity towards cyclic dinucleotides using a c-di-GMP hydrolyzing phosphodiesterase domain. Mutations to the gene confer resistance to daptomycin. Efae_YybT_DAP antibiotic_resistance ARO:3003797 Enterococcus faecalis YybT with mutation conferring daptomycin resistance YybT has phosphodiesterase activity towards cyclic dinucleotides using a c-di-GMP hydrolyzing phosphodiesterase domain. Mutations to the gene confer resistance to daptomycin. PMID:19901023 PMID:23959318 Efae_YybT_DAP Mutations to the YybT gene confers daptomycin resistance. antibiotic_resistance ARO:3003798 daptomycin resistant YybT Mutations to the YybT gene confers daptomycin resistance. PMID:19901023 PMID:23959318 gdpD is a glycerolphosphodiesterase whose mutations confer resistance to daptomycin. Efae_gdpD_DAP antibiotic_resistance ARO:3003800 Enterococcus faecalis gdpD with mutation conferring daptomycin resistance gdpD is a glycerolphosphodiesterase whose mutations confer resistance to daptomycin. PMID:23959318 Efae_gdpD_DAP Transmembrane protein which expels bicyclomycin from the cell, leading to bicyclomycin resistance. Identified in Pseudomonas aeruginosa strains responsible for outbreaks in Brazil, often appearing with blaSPM-1, another bicyclomycin resistance gene. bcr-1 antibiotic_resistance ARO:3003801 bcr-1 Transmembrane protein which expels bicyclomycin from the cell, leading to bicyclomycin resistance. Identified in Pseudomonas aeruginosa strains responsible for outbreaks in Brazil, often appearing with blaSPM-1, another bicyclomycin resistance gene. PMID:25085655 PMID:26093374 bcr-1 Mutations to the gdpD glycerolphosphodiesterase confer resistance to daptomycin. antibiotic_resistance ARO:3003802 daptomycin resistant gdpD Mutations to the gdpD glycerolphosphodiesterase confer resistance to daptomycin. PMID:23959318 agrA is an autoinducer in a peptide-quorum two-component regulatory system whose mutations confer daptomycin resistance. Saur_agrA_DAP accessory gene regulator protein A antibiotic_resistance ARO:3003803 Staphylococcus aureus agrA with mutation conferring resistance to daptomycin agrA is an autoinducer in a peptide-quorum two-component regulatory system whose mutations confer daptomycin resistance. PMID:22685286 PMID:23554895 Saur_agrA_DAP Mutations to the regulatory gene agrA confer daptomycin resistance. antibiotic_resistance ARO:3003804 daptomycin resistant agrA Mutations to the regulatory gene agrA confer daptomycin resistance. PMID:22685286 PMID:23554895 gshF is a bifunctional glutamate-cysteine ligase/ glutathione synthetase that when mutated, confers daptomycin resistance. Efae_gshF_DAP antibiotic_resistance ARO:3003805 Enterococcus faecalis gshF with mutation conferring daptomycin resistance gshF is a bifunctional glutamate-cysteine ligase/ glutathione synthetase that when mutated, confers daptomycin resistance. PMID:23959318 Efae_gshF_DAP Mutations to the glutathione synthetase gshF confers daptomycin resistance. antibiotic_resistance ARO:3003806 daptomycin resistant gshF Mutations to the glutathione synthetase gshF confers daptomycin resistance. PMID:23959318 AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli. Ecol_AcrR_MULT antibiotic_resistance ARO:3003807 Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli. PMID:16189130 Ecol_AcrR_MULT carO is a transmembrane beta-barrel involved in the influx of carbapenem antibiotics in Acinetobacter baumannii. Disruption of the carO gene by distinct insertion elements results in a loss of carO expression causing resistance to carbapenem antibiotics. Homologs of carO have been identified in genera Acinetobacter, Moraxella and Psychrobacter. carO antibiotic_resistance ARO:3003808 carO carO is a transmembrane beta-barrel involved in the influx of carbapenem antibiotics in Acinetobacter baumannii. Disruption of the carO gene by distinct insertion elements results in a loss of carO expression causing resistance to carbapenem antibiotics. Homologs of carO have been identified in genera Acinetobacter, Moraxella and Psychrobacter. PMID:15793123 carO An outer member protein (OMP) found in Acinetobacter baumannii involved in the uptake of imipenem and basic amino acids. This porin is homologous to Pseudomonas aeruginosa OprD, which performs an identical function. Abau_OprD_IPM antibiotic_resistance ARO:3003809 Acinetobacter baumannii OprD conferring resistance to imipenem An outer member protein (OMP) found in Acinetobacter baumannii involved in the uptake of imipenem and basic amino acids. This porin is homologous to Pseudomonas aeruginosa OprD, which performs an identical function. PMID:16335991 Abau_OprD_IPM Natural producers of kirromycin and kirromycin-like antibiotics (i.e., kirrothrycin) possess self-resistance, which is classified here. antibiotic_resistance ARO:3003810 kirromycin self resistant EF-Tu Natural producers of kirromycin and kirromycin-like antibiotics (i.e., kirrothrycin) possess self-resistance, which is classified here. PMID:9043138 AdeC is the outer membrane factor of the AdeABC multidrug efflux complex. It can be replaced by other outer membrane channels, and is not essential for antibiotic resistance. adeC antibiotic_resistance ARO:3003811 adeC AdeC is the outer membrane factor of the AdeABC multidrug efflux complex. It can be replaced by other outer membrane channels, and is not essential for antibiotic resistance. PMID:21173183 adeC drmA is an uncharacterized 6-pass membrane protein, with mutations to the protein causing modest resistance to daptomycin. Efae_drmA_DAP antibiotic_resistance ARO:3003813 Enterococcus faecalis drmA with mutation conferring daptomycin resistance drmA is an uncharacterized 6-pass membrane protein, with mutations to the protein causing modest resistance to daptomycin. PMID:23959318 Efae_drmA_DAP Mutations to drmA confer daptomycin resistance. antibiotic_resistance ARO:3003814 daptomycin resistant drmA Mutations to drmA confer daptomycin resistance. PMID:23959318 YvlB is a putative target of the liaFSR signalling pathway, whose mutations confer daptomycin resistance. Efae_YvlB_DAP antibiotic_resistance ARO:3003815 Enterococcus faecalis YvlB with mutation conferring daptomycin resistance YvlB is a putative target of the liaFSR signalling pathway, whose mutations confer daptomycin resistance. PMID:23959318 Efae_YvlB_DAP Mutations to the putative liaFSR target YvlB confer daptomycin resistance. antibiotic_resistance ARO:3003816 daptomycin resistant YvlB Mutations to the putative liaFSR target YvlB confer daptomycin resistance. PMID:23959318 Mutations in the A subunit of DNA gyrase reduce its affinity for fluoroquinolones, thereby conferring resistance. Abau_gyrA_FLO antibiotic_resistance ARO:3003817 Acinetobacter baumannii gyrA conferring resistance to fluoroquinolones Mutations in the A subunit of DNA gyrase reduce its affinity for fluoroquinolones, thereby conferring resistance. PMID:15282231 PMID:21304033 Abau_gyrA_FLO Mutations in Acinetobacter baumannii parC that result in resistance to fluoroquinolones. Abau_parC_FLO antibiotic_resistance ARO:3003818 Acinetobacter baumannii parC conferring resistance to fluoroquinolones Mutations in Acinetobacter baumannii parC that result in resistance to fluoroquinolones. PMID:27175500 PMID:36010006 Abau_parC_FLO mgrB is a small transmembrane protein produced in the PhoPQ signalling system. It acts as a negative regulator in this system. Inactivation or down-regulation of mgrB confers colistin resistance by absence as shown in Klebsiella pneumoniae. YobG mgrB antibiotic_resistance ARO:3003820 mgrB mgrB is a small transmembrane protein produced in the PhoPQ signalling system. It acts as a negative regulator in this system. Inactivation or down-regulation of mgrB confers colistin resistance by absence as shown in Klebsiella pneumoniae. PMID:25190723 mgrB BAL30072 is a monocyclic beta-lactam antibiotic belonging to the sulfactams. BAL30072 was found to trigger the spheroplasting and lysis of Escherichia coli rather than the formation of extensive filaments. pubchem.compound:52942440 antibiotic_resistance ARO:3003821 BAL30072 BAL30072 is a monocyclic beta-lactam antibiotic belonging to the sulfactams. BAL30072 was found to trigger the spheroplasting and lysis of Escherichia coli rather than the formation of extensive filaments. PMID:20308379 PMID:23449829 Battacin is a cationic lipopeptide antibiotic produced from a Paenibacillus tianmuensis soil isolate. Battacin kills bacteria in vitro and has potent activity against Gram-negative bacteria, including multidrug-resistant and extremely drug-resistant clinical isolates. The bactericidal kinetics of battacin correlate with the depolarization of the cell membrane, suggesting that battacin kills bacteria by disrupting the cytoplasmic membrane. octapeptin B5 antibiotic_resistance ARO:3003822 battacin Battacin is a cationic lipopeptide antibiotic produced from a Paenibacillus tianmuensis soil isolate. Battacin kills bacteria in vitro and has potent activity against Gram-negative bacteria, including multidrug-resistant and extremely drug-resistant clinical isolates. The bactericidal kinetics of battacin correlate with the depolarization of the cell membrane, suggesting that battacin kills bacteria by disrupting the cytoplasmic membrane. PMID:22183171 Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent. pubchem.compound:2330 8001-54-5 Benzalkonium D00857 Zephiran chloride antibiotic_resistance ARO:3003823 benzalkonium chloride Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent. PMID:9079913 An alanyl-tRNA synthetase conferring resistance to novobiocin in Escherichia coli. antibiotic_resistance ARO:3003830 Aminocoumarin resistant alaS An alanyl-tRNA synthetase conferring resistance to novobiocin in Escherichia coli. PMID:10217798 Temocillin is a beta-lactamase resistant carboxypenicillin. It is primarily used for the treatment of multiple drug resistant, Gram-negative bacteria, specifically Enterobacteriaceae. pubchem.compound:171758 BRL 17421 Temocilline Temocillinum antibiotic_resistance ARO:3003831 temocillin Temocillin is a beta-lactamase resistant carboxypenicillin. It is primarily used for the treatment of multiple drug resistant, Gram-negative bacteria, specifically Enterobacteriaceae. PMID:22115539 PMID:22294983 Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death. pubchem.compound:36921 Ticarcilina Ticarcilline Ticarcillinum antibiotic_resistance ARO:3003832 ticarcillin Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death. PMID:21504594 PMID:22252797 Clostridioides difficile and Escherichia coli multidrug efflux transporter with antiporter function. Confers resistance to fluoroquinolones in E. coli and acriflavin in Clostridioides difficile. cdeA antibiotic_resistance ARO:3003835 cdeA Clostridioides difficile and Escherichia coli multidrug efflux transporter with antiporter function. Confers resistance to fluoroquinolones in E. coli and acriflavin in Clostridioides difficile. PMID:15383161 cdeA qacH is a subunit of the qac multidrug efflux pump in Staphylococcus saprophyticus. qacH antibiotic_resistance ARO:3003836 qacH qacH is a subunit of the qac multidrug efflux pump in Staphylococcus saprophyticus. PMID:9631545 qacH GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and, in situations where GadX is missing, activates gadA and gadBC. YhiW gadW antibiotic_resistance ARO:3003838 gadW GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and, in situations where GadX is missing, activates gadA and gadBC. PMID:12446650 PMID:16980449 gadW Mrx is part of the macrolide inactivation gene cluster in Aeromonas hydrophila. Mrx antibiotic_resistance ARO:3003839 Mrx Mrx is part of the macrolide inactivation gene cluster in Aeromonas hydrophila. PMID:16339607 Mrx Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin, an aminocoumarin antibiotic, in Escherichia coli. antibiotic_resistance ARO:3003840 aminocoumarin resistant cysB Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin, an aminocoumarin antibiotic, in Escherichia coli. PMID:1886615 kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding. kdpE antibiotic_resistance ARO:3003841 kdpE kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding. PMID:12618449 PMID:23555240 kdpE MUS-2 is a chromosome-encoded beta-lactamase from Myroides odoratimimus. MUS-2 antibiotic_resistance ARO:3003842 MUS-2 MUS-2 is a chromosome-encoded beta-lactamase from Myroides odoratimimus. PMID:26257915 MUS-2 leuO, a LysR family transcription factor, exists in a wide variety of bacteria of the family Enterobacteriaceae and is involved in the regulation of as yet unidentified genes affecting the stress response and pathogenesis expression. LeuO is also an activator of the MdtNOP efflux pump. leuO antibiotic_resistance ARO:3003843 leuO leuO, a LysR family transcription factor, exists in a wide variety of bacteria of the family Enterobacteriaceae and is involved in the regulation of as yet unidentified genes affecting the stress response and pathogenesis expression. LeuO is also an activator of the MdtNOP efflux pump. PMID:19429622 PMID:21883529 leuO mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. The Mfd (mutation frequency decline) protein, also known as transcription-repair coupling factor, is responsible for ATP-dependent removal of stalled RNA polymerase from DNA lesions by inducing forward movement of the RNA polymerase and subsequent recruitment of nucleotide excision repair machinery to the sites of the lesions. mfd antibiotic_resistance ARO:3003844 mfd mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. The Mfd (mutation frequency decline) protein, also known as transcription-repair coupling factor, is responsible for ATP-dependent removal of stalled RNA polymerase from DNA lesions by inducing forward movement of the RNA polymerase and subsequent recruitment of nucleotide excision repair machinery to the sites of the lesions. PMID:17239578 PMID:18535657 mfd ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis. antibiotic_resistance ARO:3003846 ADC beta-lactamase without carbapenemase activity ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis. PMID:15980372 ADC-1 is a beta-lactamase found in Acinetobacter baumannii. ADC-1 antibiotic_resistance ARO:3003847 ADC-1 ADC-1 is a beta-lactamase found in Acinetobacter baumannii. PMID:10639377 ADC-1 ADC-2 is a beta-lactamase found in Oligella urethralis. ADC-2 antibiotic_resistance ARO:3003848 ADC-2 ADC-2 is a beta-lactamase found in Oligella urethralis. PMID:12709319 ADC-2 ADC-3 is a beta-lactamase found in Acinetobacter baumannii. ADC-3 antibiotic_resistance ARO:3003849 ADC-3 ADC-3 is a beta-lactamase found in Acinetobacter baumannii. PMID:12709319 ADC-3 ADC-4 is a beta-lactamase found in Acinetobacter baumannii. ADC-4 antibiotic_resistance ARO:3003850 ADC-4 ADC-4 is a beta-lactamase found in Acinetobacter baumannii. PMID:12709319 ADC-4 ADC-5 is a beta-lactamase found in Acinetobacter pittii. ADC-5 antibiotic_resistance ARO:3003851 ADC-5 ADC-5 is a beta-lactamase found in Acinetobacter pittii. PMID:15047547 ADC-5 ADC-6 is a beta-lactamase found in Acinetobacter baumannii. ADC-6 antibiotic_resistance ARO:3003852 ADC-6 ADC-6 is a beta-lactamase found in Acinetobacter baumannii. PMID:14742218 ADC-6 ADC-7 is a beta-lactamase that is found in Acinetobacter baumannii. ADC-7 antibiotic_resistance ARO:3003853 ADC-7 ADC-7 is a beta-lactamase that is found in Acinetobacter baumannii. PMID:15980372 ADC-7 ADC-8 is a beta-lactamase found in Acinetobacter sp. ADC-8 antibiotic_resistance ARO:3003854 ADC-8 ADC-8 is a beta-lactamase found in Acinetobacter sp. PMID:17403709 ADC-8 ADC-10 is a beta-lactamase found in Acinetobacter baumannii. ADC-10 antibiotic_resistance ARO:3003855 ADC-10 ADC-10 ADC-12 is a beta-lactamase found in Acinetobacter pittii. ADC-12 antibiotic_resistance ARO:3003856 ADC-12 ADC-12 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-12 ADC-13 is a beta-lactamase found in Acinetobacter pittii. ADC-13 antibiotic_resistance ARO:3003857 ADC-13 ADC-13 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-13 ADC-14 is a beta-lactamase found in Acinetobacter pittii. ADC-14 antibiotic_resistance ARO:3003858 ADC-14 ADC-14 is a beta-lactamase found in Acinetobacter pittii. PMID:18065824 PMID:19029333 ADC-14 ADC-15 is a beta-lactamase found in Acinetobacter pittii. ADC-15 antibiotic_resistance ARO:3003859 ADC-15 ADC-15 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-15 ADC-16 is a beta-lactamase found in Acinetobacter pittii. ADC-16 antibiotic_resistance ARO:3003860 ADC-16 ADC-16 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-16 ADC-17 is a beta-lactamase found in Acinetobacter pittii. ADC-17 antibiotic_resistance ARO:3003861 ADC-17 ADC-17 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-17 ADC-18 is a beta-lactamase found in Acinetobacter pittii. ADC-18 antibiotic_resistance ARO:3003862 ADC-18 ADC-18 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-18 ADC-19 is a beta-lactamase found in Acinetobacter pittii. ADC-19 antibiotic_resistance ARO:3003863 ADC-19 ADC-19 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-19 ADC-20 is a beta-lactamase found in Acinetobacter pittii. ADC-20 antibiotic_resistance ARO:3003864 ADC-20 ADC-20 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-20 ADC-21 is a beta-lactamase found in Acinetobacter pittii. ADC-21 antibiotic_resistance ARO:3003865 ADC-21 ADC-21 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-21 ADC-22 is a beta-lactamase found in Acinetobacter pittii. ADC-22 antibiotic_resistance ARO:3003866 ADC-22 ADC-22 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-22 ADC-23 is a beta-lactamase found in Acinetobacter pittii. ADC-23 antibiotic_resistance ARO:3003867 ADC-23 ADC-23 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-23 ADC-25 is a beta-lactamase found in Acinetobacter baumannii. ADC-25 antibiotic_resistance ARO:3003868 ADC-25 ADC-25 is a beta-lactamase found in Acinetobacter baumannii. PMID:18077141 ADC-25 ADC-31 is a beta-lactamase found in Acinetobacter baumannii. ADC-31 antibiotic_resistance ARO:3003870 ADC-31 ADC-31 is a beta-lactamase found in Acinetobacter baumannii. PMID:22038960 ADC-31 ADC-39 is a beta-lactamase found in Acinetobacter baumannii. ADC-39 antibiotic_resistance ARO:3003871 ADC-39 ADC-39 is a beta-lactamase found in Acinetobacter baumannii. PMID:18765689 ADC-39 ADC-41 is a beta-lactamase found in Acinetobacter pittii. ADC-41 antibiotic_resistance ARO:3003872 ADC-41 ADC-41 is a beta-lactamase found in Acinetobacter pittii. PMID:20368407 ADC-41 ADC-42 is a beta-lactamase found in Acinetobacter pittii. ADC-42 antibiotic_resistance ARO:3003873 ADC-42 ADC-42 is a beta-lactamase found in Acinetobacter pittii. PMID:20368407 ADC-42 ADC-43 is a beta-lactamase found in Acinetobacter pittii. ADC-43 antibiotic_resistance ARO:3003874 ADC-43 ADC-43 is a beta-lactamase found in Acinetobacter pittii. PMID:20368407 ADC-43 Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to elfamycin antibiotics. antibiotic_resistance ARO:3003875 Enterococcus faecium EF-Tu mutants conferring resistance to elfamycin Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to elfamycin antibiotics. PMID:7989561 ADC-44 is a beta-lactamase found in Acinetobacter pittii. ADC-44 antibiotic_resistance ARO:3003876 ADC-44 ADC-44 is a beta-lactamase found in Acinetobacter pittii. PMID:20368407 ADC-44 ADC-56 is a beta-lactamase found in Acinetobacter baumannii. ADC-56 antibiotic_resistance ARO:3003878 ADC-56 ADC-56 is a beta-lactamase found in Acinetobacter baumannii. PMID:21788456 ADC-56 ADC-61 is a beta-lactamase found in Acinetobacter baumannii. ADC-61 antibiotic_resistance ARO:3003879 ADC-61 ADC-61 is a beta-lactamase found in Acinetobacter baumannii. PMID:26125919 ADC-61 ADC-74 is a beta-lactamase found in Acinetobacter baumannii. ADC-74 antibiotic_resistance ARO:3003880 ADC-74 ADC-74 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-74 ADC-75 is a beta-lactamase found in Acinetobacter baumannii. ADC-75 antibiotic_resistance ARO:3003881 ADC-75 ADC-75 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-75 ADC-76 is a beta-lactamase found in Acinetobacter baumannii. ADC-76 antibiotic_resistance ARO:3003882 ADC-76 ADC-76 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-76 ADC-77 is a beta-lactamase found in Acinetobacter baumannii. ADC-77 antibiotic_resistance ARO:3003883 ADC-77 ADC-77 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-77 ADC-78 is a beta-lactamase found in Acinetobacter baumannii. ADC-78 antibiotic_resistance ARO:3003884 ADC-78 ADC-78 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-78 ADC-79 is a beta-lactamase found in Acinetobacter baumannii. ADC-79 antibiotic_resistance ARO:3003885 ADC-79 ADC-79 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-79 ADC-80 is a beta-lactamase found in Acinetobacter baumannii. ADC-80 antibiotic_resistance ARO:3003886 ADC-80 ADC-80 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-80 ADC-81 is a beta-lactamase found in Acinetobacter baumannii. ADC-81 antibiotic_resistance ARO:3003887 ADC-81 ADC-81 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-81 ADC-82 is a beta-lactamase found in Acinetobacter baumannii. ADC-82 antibiotic_resistance ARO:3003888 ADC-82 ADC-82 is a beta-lactamase found in Acinetobacter baumannii. PMID:21398552 PMID:22952140 ADC-82 Point mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. Ecol_GlpT_FOF antibiotic_resistance ARO:3003889 Escherichia coli GlpT with mutation conferring resistance to fosfomycin Point mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. PMID:12936984 PMID:20071153 Ecol_GlpT_FOF Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. Ecol_UhpT_FOF antibiotic_resistance ARO:3003890 Escherichia coli UhpT with mutation conferring resistance to fosfomycin Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. PMID:20071153 Ecol_UhpT_FOF uhpA is a positive activator of the fosfomycin importer uhpT, thus mutations to uhpA confer fosfomycin resistance by reducing uhpT expression. Both knockout and amino acid substitution mutations have been found that confer resistance, with the Protein Knockout model describing the large, knockout mutations causing loss of function of the gene, and the Protein Variant model describing the amino acid substitutions. Ecol_uhpA_FOF antibiotic_resistance ARO:3003893 Escherichia coli uhpA with mutation conferring resistance to fosfomycin uhpA is a positive activator of the fosfomycin importer uhpT, thus mutations to uhpA confer fosfomycin resistance by reducing uhpT expression. Both knockout and amino acid substitution mutations have been found that confer resistance, with the Protein Knockout model describing the large, knockout mutations causing loss of function of the gene, and the Protein Variant model describing the amino acid substitutions. PMID:20071153 Ecol_uhpA_FOF Rm3 is a class B3 metallo-beta-lactamase isolated from a metagenomic soil sample in Yorkshire, United Kingdom, shown to confer resistance to clinically used penicillins, cephalosporins, and carbapenems. Rm3 antibiotic_resistance ARO:3003894 Rm3 Rm3 is a class B3 metallo-beta-lactamase isolated from a metagenomic soil sample in Yorkshire, United Kingdom, shown to confer resistance to clinically used penicillins, cephalosporins, and carbapenems. PMID:27431213 Rm3 Mutations in Pseudomonas aeruginosa PhoP of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin. Paer_PhoP_CST antibiotic_resistance ARO:3003895 Pseudomonas mutant PhoP conferring resistance to colistin Mutations in Pseudomonas aeruginosa PhoP of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin. PMID:24412662 Paer_PhoP_CST Mutations in Pseudomonas aeruginosa PhoQ of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin. Paer_PhoQ_CST antibiotic_resistance ARO:3003896 Pseudomonas mutant PhoQ conferring resistance to colistin Mutations in Pseudomonas aeruginosa PhoQ of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin. PMID:24412662 Paer_PhoQ_CST Tedizolid is a synthetic oxazolidinone antibiotic that is administered to the patient as a prodrug that is activated in vivo. It acts as an inhibitor of protein synthesis by binding the 50S subunit of the ribosome and preventing formation of the 70S initiation complex. It is active against Gram-positive pathogens. pubchem.compound:11234049 antibiotic_resistance ARO:3003897 tedizolid Tedizolid is a synthetic oxazolidinone antibiotic that is administered to the patient as a prodrug that is activated in vivo. It acts as an inhibitor of protein synthesis by binding the 50S subunit of the ribosome and preventing formation of the 70S initiation complex. It is active against Gram-positive pathogens. PMID:22324973 PMID:27904526 Lugdunin is a thiazolidine-containing cyclic peptide antibiotic isolated from nasal Staphylococcus lugnunensis that prohibits Staphylococcus aureus colony formation. It is a human commensal bacteria, indicating the potential for further antibiotic discoveries from human microbiota. pubchem.compound:121596231 antibiotic_resistance ARO:3003898 lugdunin Lugdunin is a thiazolidine-containing cyclic peptide antibiotic isolated from nasal Staphylococcus lugnunensis that prohibits Staphylococcus aureus colony formation. It is a human commensal bacteria, indicating the potential for further antibiotic discoveries from human microbiota. PMID:27466123 PtsI (phosphoenolpyruvate-protein phosphotransferase) is involved in cyclic AMP synthesis, which regulates glpT expression. As a result, mutations to ptsI confer resistance to fosfomycin by affecting the regulation of fosfomycin import. Ecol_PtsI_FOF phosphoenolpyruvate-protein phosphotransferase antibiotic_resistance ARO:3003899 Escherichia coli PtsI with mutation conferring resistance to fosfomycin PtsI (phosphoenolpyruvate-protein phosphotransferase) is involved in cyclic AMP synthesis, which regulates glpT expression. As a result, mutations to ptsI confer resistance to fosfomycin by affecting the regulation of fosfomycin import. PMID:20071153 Ecol_PtsI_FOF CyaA (adenylate cyclase) is involved with the synthesis of cyclic AMP which regulates the fosfomycin transporter glpT. As a result, mutations to cyaA confer resistance to fosfomycin. Ecol_cyaA_FOF adenylate cyclase antibiotic_resistance ARO:3003900 Escherichia coli cyaA with mutation conferring resistance to fosfomycin CyaA (adenylate cyclase) is involved with the synthesis of cyclic AMP which regulates the fosfomycin transporter glpT. As a result, mutations to cyaA confer resistance to fosfomycin. PMID:14519998 PMID:20071153 Ecol_cyaA_FOF Mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. Saur_GlpT_FOF antibiotic_resistance ARO:3003901 Staphylococcus aureus GlpT with mutation conferring resistance to fosfomycin Mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. PMID:26793179 Saur_GlpT_FOF Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. Saur_UhpT_FOF antibiotic_resistance ARO:3003902 Staphylococcus aureus UhpT with mutation conferring resistance to fosfomycin Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. PMID:26793179 Saur_UhpT_FOF Thusin is a two-component lantibiotic isolated from B. thuringiensis strain BGSC 4BT1, exhibiting antimicrobial activity against several Gram-positive pathogens. Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus (MRSA), Mammaliicoccus sciuri, Enterococcus faecalis, and Streptococcus pneumoniae have all shown susceptibility to Thusin, with inhibition activities greater than Vancomycin or other lantibiotics. antibiotic_resistance ARO:3003903 thusin Thusin is a two-component lantibiotic isolated from B. thuringiensis strain BGSC 4BT1, exhibiting antimicrobial activity against several Gram-positive pathogens. Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus (MRSA), Mammaliicoccus sciuri, Enterococcus faecalis, and Streptococcus pneumoniae have all shown susceptibility to Thusin, with inhibition activities greater than Vancomycin or other lantibiotics. PMID:27486447 Formicin is a two-component broad-spectrum lantibiotic produced by Bacillus paralicheniformis APC 1576, exhibiting antimicrobial activity against several Gram-positive species, including Staphylococcus aureus, Clostridioides difficile and Listeria monocytogenes. pubchem.compound:69365 antibiotic_resistance ARO:3003904 formicin Formicin is a two-component broad-spectrum lantibiotic produced by Bacillus paralicheniformis APC 1576, exhibiting antimicrobial activity against several Gram-positive species, including Staphylococcus aureus, Clostridioides difficile and Listeria monocytogenes. PMID:27450592 Aminoglycoside nucleotidyltransferase sequence from Staphylococcus aureus plasmid. ANT(4')-Ib aadD2 antibiotic_resistance ARO:3003905 ANT(4')-Ib Aminoglycoside nucleotidyltransferase sequence from Staphylococcus aureus plasmid. PMID:12654668 PMID:20585117 ANT(4')-Ib Cfr-like methyltransferase enzyme conferring resistance to multiple clinically relevant antibiotic classes. cipA antibiotic_resistance ARO:3003907 cipA Cfr-like methyltransferase enzyme conferring resistance to multiple clinically relevant antibiotic classes. PMID:23752511 cipA Chromosome-encoded gene conferring MLSB resistance. Identified from Helcococcus kunzii. Erm(47) antibiotic_resistance ARO:3003908 Erm(47) Chromosome-encoded gene conferring MLSB resistance. Identified from Helcococcus kunzii. PMID:27494920 Erm(47) A drug which binds to menaquinone in the bacterial cell membrane. Binding of Lysocin to menaquinone facilitates lysis of the cell. pubchem.compound:53373747 antibiotic_resistance ARO:3003915 Lysocin E A drug which binds to menaquinone in the bacterial cell membrane. Binding of Lysocin to menaquinone facilitates lysis of the cell. PMID:25485686 A molecule involved in electron transport in bacterial cell membrane. pubchem.compound:5287554 Vitamin K2 antibiotic_resistance ARO:3003916 menaquinone A molecule involved in electron transport in bacterial cell membrane. PMID:25485686 menA encodes a 1,4-dihydroxy-2-naphthoate octaprenyltransferase, with mutations to the protein conferring resistance to lysocin E. Saur_menA_LYS antibiotic_resistance ARO:3003917 Staphylococcus aureus menA with mutation conferring resistance to lysocin menA encodes a 1,4-dihydroxy-2-naphthoate octaprenyltransferase, with mutations to the protein conferring resistance to lysocin E. PMID:25485686 Saur_menA_LYS Plasmid-borne apramycin-resistant aminocyclitol acetyltransferase gene identified from bovine MRSA. apmA antibiotic_resistance ARO:3003918 apmA Plasmid-borne apramycin-resistant aminocyclitol acetyltransferase gene identified from bovine MRSA. PMID:20876371 PMID:33563840 PMID:37973888 apmA Lysocin family of peptide antibiotics isolated from Lysobacter spp. antibiotic_resistance ARO:3003919 lysocin Lysocin family of peptide antibiotics isolated from Lysobacter spp. PMID:25485686 A gene that produces the protein lipid A 4'-phosphatase. PGN-0524 pgpB antibiotic_resistance ARO:3003920 pgpB A gene that produces the protein lipid A 4'-phosphatase. PMID:20657724 pgpB oqxAB encodes for OqxAB, a plasmid-encoded efflux pump, which confer resistance to multiple agents including fluoroquinolones. oqxAB antibiotic_resistance ARO:3003921 oqxAB oqxAB encodes for OqxAB, a plasmid-encoded efflux pump, which confer resistance to multiple agents including fluoroquinolones. PMID:19528276 oqxAB RND efflux pump conferring resistance to fluoroquinolone. oqxA antibiotic_resistance ARO:3003922 oqxA RND efflux pump conferring resistance to fluoroquinolone. PMID:19528276 oqxA RND efflux pump conferring resistance to fluoroquinolone. oqxB antibiotic_resistance ARO:3003923 oqxB RND efflux pump conferring resistance to fluoroquinolone. PMID:19528276 oqxB Point mutation of Haemophilus parainfluenzae gyrA resulted in the lowered affinity between fluoroquinolones and GyrA. Thus, conferring resistance. Both Ser and Tyr are hydrophilic amino acids, however Tyr has an additional bulky hydrophobic group which could affect the interaction between the DNA gyrase with quinolones. Hpin_gyrA_FLO antibiotic_resistance ARO:3003924 Haemophilus parainfluenzae gyrA conferring resistance to fluoroquinolones Point mutation of Haemophilus parainfluenzae gyrA resulted in the lowered affinity between fluoroquinolones and GyrA. Thus, conferring resistance. Both Ser and Tyr are hydrophilic amino acids, however Tyr has an additional bulky hydrophobic group which could affect the interaction between the DNA gyrase with quinolones. PMID:27497656 Hpin_gyrA_FLO Point mutation of Haemophilus parainfluenzae parC resulted in the lowered affinity between fluoroquinolones and ParC. Thus, conferring resistance. Hpin_parC_FLO antibiotic_resistance ARO:3003925 Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones Point mutation of Haemophilus parainfluenzae parC resulted in the lowered affinity between fluoroquinolones and ParC. Thus, conferring resistance. PMID:27497656 Hpin_parC_FLO Point mutations in Salmonella gyrA that confer resistance to Nalidixic acid, a fluoroquinolone antibiotic. These mutations have also been shown to reduce susceptibility to ciprofloxacin. Sent_gyrA_FLO antibiotic_resistance ARO:3003926 Salmonella enterica gyrA conferring resistance to fluoroquinolones Point mutations in Salmonella gyrA that confer resistance to Nalidixic acid, a fluoroquinolone antibiotic. These mutations have also been shown to reduce susceptibility to ciprofloxacin. PMID:27559761 PMID:27630841 Sent_gyrA_FLO A fifth generation cephalosporin antibiotic. pubchem.compound:53234134 Zerbaxa antibiotic_resistance ARO:3003927 ceftolozane A fifth generation cephalosporin antibiotic. PMID:27522066 Point mutation in Neisseria gonorrhoeae DNA gyrase subunit A. Decreases affinity between fluoroquinolone antibiotic molecule and gyrA, thereby conferring resistance to fluoroquinolone. Ngon_gyrA_FLO antibiotic_resistance ARO:3003928 Neisseria gonorrhoeae gyrA conferring resistance to fluoroquinolones Point mutation in Neisseria gonorrhoeae DNA gyrase subunit A. Decreases affinity between fluoroquinolone antibiotic molecule and gyrA, thereby conferring resistance to fluoroquinolone. PMID:27506605 PMID:30961546 Ngon_gyrA_FLO Point mutations in Neisseria gonorrhoeae parC protein that confer resistance to fluoroquinolone by reducing affinity to antibiotic binding site. Ngon_parC_FLO antibiotic_resistance ARO:3003929 Neisseria gonorrhoeae parC conferring resistance to fluoroquinolones Point mutations in Neisseria gonorrhoeae parC protein that confer resistance to fluoroquinolone by reducing affinity to antibiotic binding site. PMID:27506605 PMID:30961546 Ngon_parC_FLO rpsJ is a tetracycline resistance protein identified in Neisseria gonorrhoeae. Tetracycline resistance is conferred by binding to the ribosome as a 30S ribosomal protection protein. nusE rpsJ antibiotic_resistance ARO:3003930 rpsJ rpsJ is a tetracycline resistance protein identified in Neisseria gonorrhoeae. Tetracycline resistance is conferred by binding to the ribosome as a 30S ribosomal protection protein. PMID:27506605 rpsJ Point mutation in Capnocytophaga gingivalis that decreases binding affinity of fluoroquinolone antibiotics to gyrA, thereby conferring resistance. Cgin_gyrA_FLO antibiotic_resistance ARO:3003931 Capnocytophaga gingivalis gyrA conferring resistance to fluoroquinolones Point mutation in Capnocytophaga gingivalis that decreases binding affinity of fluoroquinolone antibiotics to gyrA, thereby conferring resistance. PMID:27531625 Cgin_gyrA_FLO Compounds and molecules that inhibit the action of antibiotic efflux proteins, thereby decreasing resistance caused by efflux pumps. antibiotic_resistance ARO:3003932 antibiotic efflux inhibitor Berberine is a benzylisoquinoline alkaloid shown to reduce MexXY-dependent antibiotic resistance of cephalosporins, macrolides, lincosamides and aminoglycosides in Pseudomonas, Burkholderia and Achromobacter. pubchem.compound:2353 antibiotic_resistance ARO:3003933 Berberine Berberine is a benzylisoquinoline alkaloid shown to reduce MexXY-dependent antibiotic resistance of cephalosporins, macrolides, lincosamides and aminoglycosides in Pseudomonas, Burkholderia and Achromobacter. PMID:27547203 An aminomethylcycline antibiotic that targets 16s rRNA in gram positive and gram negative bacteria. pubchem.compound:54697325 antibiotic_resistance ARO:3003936 Omadacycline An aminomethylcycline antibiotic that targets 16s rRNA in gram positive and gram negative bacteria. PMID:27669321 Point mutation in Neisseria meningititis PBP2 (penA) decreases affinity between beta-lactam antibiotic molecule and PBP2, thereby conferring resistance to beta-lactam. Nmen_PBP2_BLA antibiotic_resistance ARO:3003937 Neisseria meningititis PBP2 conferring resistance to beta-lactam Point mutation in Neisseria meningititis PBP2 (penA) decreases affinity between beta-lactam antibiotic molecule and PBP2, thereby conferring resistance to beta-lactam. PMID:16940068 PMID:18986991 PMID:25199775 PMID:25987627 PMID:26787702 PMID:27690121 Nmen_PBP2_BLA Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics. antibiotic_resistance ARO:3003938 Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics Point mutations in Salmonella parC gene implicated in decreased susceptibility to fluoroquinolone antibiotics, primarily ciprofloxacin and nalidixic acid. Sent_parC_FLO antibiotic_resistance ARO:3003939 Salmonella enterica parC conferring resistance to fluoroquinolones Point mutations in Salmonella parC gene implicated in decreased susceptibility to fluoroquinolone antibiotics, primarily ciprofloxacin and nalidixic acid. PMID:27630841 Sent_parC_FLO Point mutations in Shigella flexneri gyrA observed to confer resistance to fluoroquinolone antibiotics. Sfle_gyrA_FLO antibiotic_resistance ARO:3003940 Shigella flexneri gyrA conferring resistance to fluoroquinolones Point mutations in Shigella flexneri gyrA observed to confer resistance to fluoroquinolone antibiotics. PMID:27620866 Sfle_gyrA_FLO Point mutation in parC conferring resistance to fluoroquinolone antibiotics in Shigella flexneri,. Sfle_parC_FLO antibiotic_resistance ARO:3003941 Shigella flexneri parC conferring resistance to fluoroquinolones Point mutation in parC conferring resistance to fluoroquinolone antibiotics in Shigella flexneri,. PMID:27620866 Sfle_parC_FLO AbcA is a multidrug resistant ABC transporter that confers resistance to methicillin, daptomycin, cefotaxime, and moenomycin. abcA antibiotic_resistance ARO:3003942 abcA AbcA is a multidrug resistant ABC transporter that confers resistance to methicillin, daptomycin, cefotaxime, and moenomycin. PMID:19800843 PMID:24509312 PMID:26160745 abcA EfrAB is a heterodimeric ABC transporter efflux pump found in Enterococcus faecalis and Enterococcus faecium that confers resistance to ciprofloxacin, erythromycin, rifampicin, quinupristine. antibiotic_resistance ARO:3003947 EfrAB EfrAB is a heterodimeric ABC transporter efflux pump found in Enterococcus faecalis and Enterococcus faecium that confers resistance to ciprofloxacin, erythromycin, rifampicin, quinupristine. PMID:14638474 PMID:25084670 efrA is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer drug resistance. efrA antibiotic_resistance ARO:3003948 efrA efrA is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer drug resistance. PMID:14638474 PMID:25084670 efrA efrB is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer multidrug resistance. efrB antibiotic_resistance ARO:3003949 efrB efrB is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer multidrug resistance. PMID:14638474 PMID:25084670 efrB MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability. msbA antibiotic_resistance ARO:3003950 msbA MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability. PMID:12195740 PMID:12358070 PMID:19678712 PMID:27499013 msbA Microcin J25 is a peptide antibiotic that inhibits transcription by bacterial RNA polymerase. MccJ25 is produced by Escherichia coli strains that harbor a plasmid-borne antibiotic-synthesis and antibiotic-export cassette, consisting of a gene for MccJ25 precursor (a 58 residue linear peptide), two genes for factors that process MccJ25 precursor into MccJ25, and one gene for export of MccJ25. pubchem.compound:10793809 MccJ25 antibiotic_resistance ARO:3003951 microcin J25 Microcin J25 is a peptide antibiotic that inhibits transcription by bacterial RNA polymerase. MccJ25 is produced by Escherichia coli strains that harbor a plasmid-borne antibiotic-synthesis and antibiotic-export cassette, consisting of a gene for MccJ25 precursor (a 58 residue linear peptide), two genes for factors that process MccJ25 precursor into MccJ25, and one gene for export of MccJ25. PMID:15200952 YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. YojI antibiotic_resistance ARO:3003952 YojI YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. PMID:15866933 YojI hmrM is a multidrug efflux pump belonging to the MATE family and functions as a Na+/drug antiporter. hmrM antibiotic_resistance ARO:3003953 hmrM hmrM is a multidrug efflux pump belonging to the MATE family and functions as a Na+/drug antiporter. PMID:14695443 PMID:16614254 hmrM efmA is an MFS transporter permease in E. faecium. efmA antibiotic_resistance ARO:3003954 efmA efmA is an MFS transporter permease in E. faecium. PMID:19252300 efmA efpA is an MFS transporter found in Mycobacterium tuberculosis. efpA antibiotic_resistance ARO:3003955 efpA efpA is an MFS transporter found in Mycobacterium tuberculosis. PMID:15215089 PMID:21871582 PMID:9008277 efpA Amongst the diverse and potent biological activities of free fatty acids (FFAs) is the ability to kill or inhibit the growth of bacteria. The antibacterial properties of FFAs are used by many organisms to defend against parasitic or pathogenic bacteria. The prime target of FFA action is the cell membrane, where FFAs disrupt the electron transport chain and oxidative phosphorylation. Besides interfering with cellular energy production, FFA action may also result from the inhibition of enzyme activity, impairment of nutrient uptake, generation of peroxidation and auto-oxidation degradation products or direct lysis of bacterial cells. antibiotic_resistance ARO:3003956 antibacterial free fatty acids Amongst the diverse and potent biological activities of free fatty acids (FFAs) is the ability to kill or inhibit the growth of bacteria. The antibacterial properties of FFAs are used by many organisms to defend against parasitic or pathogenic bacteria. The prime target of FFA action is the cell membrane, where FFAs disrupt the electron transport chain and oxidative phosphorylation. Besides interfering with cellular energy production, FFA action may also result from the inhibition of enzyme activity, impairment of nutrient uptake, generation of peroxidation and auto-oxidation degradation products or direct lysis of bacterial cells. PMID:19956944 Palmitic acid is the most common saturated fatty acid found in animals, plants, and microorganisms. Palmitic acid is found to have antibacterial properties. pubchem.compound:985 Cetylic acid Hexadecanoic acid N-Hexadecanoic acid Palmitate antibiotic_resistance ARO:3003957 palmitic acid Palmitic acid is the most common saturated fatty acid found in animals, plants, and microorganisms. Palmitic acid is found to have antibacterial properties. PMID:10447892 PMID:11744302 PMID:19956944 Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. Oleic acid is found to have antibacterial activity, particularly in inhibiting the growth of several Gram-positive bacterial species. pubchem.compound:445639 Cis-9-Octadecenoic acid Cis-Oleic acid Elaidoic acid Oleate antibiotic_resistance ARO:3003958 oleic acid Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. Oleic acid is found to have antibacterial activity, particularly in inhibiting the growth of several Gram-positive bacterial species. PMID:10447892 PMID:10925024 PMID:18754790 PMID:19956944 PMID:393631 Linoleic acid is a polyunsaturated omega-6 fatty acid. Linoleic acid has been found to have antibacterial activity, particularly in inhibiting the growth of Gram-positive bacterial species. pubchem.compound:5280450 Linoleate Linolic acid Telfairic acid antibiotic_resistance ARO:3003959 linoleic acid Linoleic acid is a polyunsaturated omega-6 fatty acid. Linoleic acid has been found to have antibacterial activity, particularly in inhibiting the growth of Gram-positive bacterial species. PMID:10447892 PMID:10925024 PMID:19956944 PMID:93615 farAB is an MFS efflux pump found in gonococci that is involved in antibacterial fatty acid resistance. Moreover, expression of the tandemly linked farA and farB genes was positively associated with the presence of the MtrR transcriptional regulatory protein that normally downregulates the expression of mtrCDE. antibiotic_resistance ARO:3003960 farAB farAB is an MFS efflux pump found in gonococci that is involved in antibacterial fatty acid resistance. Moreover, expression of the tandemly linked farA and farB genes was positively associated with the presence of the MtrR transcriptional regulatory protein that normally downregulates the expression of mtrCDE. PMID:10447892 farA is the membrane fusion protein that is part of the farAB efflux pump. farA antibiotic_resistance ARO:3003961 farA farA is the membrane fusion protein that is part of the farAB efflux pump. PMID:10447892 farA farB is the cytoplasmic transporter protein that is part of the farAB efflux pump. farB corresponds to 3 loci in Pseudomonas aeruginosa PAO1 and 3 loci in Pseudomonas aeruginosa LESB58. farB antibiotic_resistance ARO:3003962 farB farB is the cytoplasmic transporter protein that is part of the farAB efflux pump. farB corresponds to 3 loci in Pseudomonas aeruginosa PAO1 and 3 loci in Pseudomonas aeruginosa LESB58. PMID:10447892 farB The Flo transporters can be plasmid- or chromosome-encoded. flo is an important determinant of florfenicol resistance in animal isolates of E. coli but is also found in human pathogens (e.g. Salmonella enterica and V. cholerae). antibiotic_resistance ARO:3003963 flo The Flo transporters can be plasmid- or chromosome-encoded. flo is an important determinant of florfenicol resistance in animal isolates of E. coli but is also found in human pathogens (e.g. Salmonella enterica and V. cholerae). PMID:10639375 PMID:11101601 PMID:15914491 hp1181 is a translocase that is part of the MFS efflux pump family. It is found in H. pylori and has role in the active efflux of antibiotics. hp1181 antibiotic_resistance ARO:3003964 hp1181 hp1181 is a translocase that is part of the MFS efflux pump family. It is found in H. pylori and has role in the active efflux of antibiotics. PMID:27303615 hp1181 hp1184 is a translocase that belongs to the MATE efflux pump family. It is found in H. pylori and is involved in the active efflux of antibiotics. hp1184 antibiotic_resistance ARO:3003965 hp1184 hp1184 is a translocase that belongs to the MATE efflux pump family. It is found in H. pylori and is involved in the active efflux of antibiotics. PMID:15793129 PMID:27303615 hp1184 Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK35 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism. Kpne_OmpK35 antibiotic_resistance ARO:3003966 Klebsiella pneumoniae OmpK35 Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK35 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism. PMID:27645385 Kpne_OmpK35 lfrA is involved in the active efflux of quinolones and is found in Mycobacteroides abscessus. lfrA antibiotic_resistance ARO:3003967 lfrA lfrA is involved in the active efflux of quinolones and is found in Mycobacteroides abscessus. PMID:8682782 lfrA Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK36 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism. Kpne_OmpK36 antibiotic_resistance ARO:3003968 Klebsiella pneumoniae OmpK36 Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK36 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism. PMID:27645385 Kpne_OmpK36 lmrP is a proton motive force-dependent drug transporter that is part of the MFS efflux pump family. lmrP antibiotic_resistance ARO:3003969 lmrP lmrP is a proton motive force-dependent drug transporter that is part of the MFS efflux pump family. PMID:10532389 PMID:11577166 PMID:7592810 lmrP Non-van ligases that synthesize D-Ala-D-Ala, the default cell wall precursor that makes a cell vulnerable to glycopeptide antibiotics. Mutations in the ddl gene can cause the production of nonfunctional/inactivated D-Ala-D-Ala ligases, which can render bacteria glycopeptide dependent depending on the presence of vancomycin resistance clusters. Ddl antibiotic_resistance ARO:3003970 D-Ala-D-Ala ligase Non-van ligases that synthesize D-Ala-D-Ala, the default cell wall precursor that makes a cell vulnerable to glycopeptide antibiotics. Mutations in the ddl gene can cause the production of nonfunctional/inactivated D-Ala-D-Ala ligases, which can render bacteria glycopeptide dependent depending on the presence of vancomycin resistance clusters. PMID:11274474 PMID:16323116 Ddl Variant of Erm(44)v isolated from Staphylococcus saprophyticus, confers resistance to lincosamide and macrolide antibiotics but not streptogramins. Erm(44)v antibiotic_resistance ARO:3003971 Erm(44)v Variant of Erm(44)v isolated from Staphylococcus saprophyticus, confers resistance to lincosamide and macrolide antibiotics but not streptogramins. PMID:27799208 Erm(44)v A clinically developed Macrolide antibiotic targeting gram positive and gram negative bacteria. pubchem.compound:72734351 CEM-101 antibiotic_resistance ARO:3003972 Solithromycin A clinically developed Macrolide antibiotic targeting gram positive and gram negative bacteria. PMID:27909995 Point mutations in Cutibacterium acnes gyrA protein known to confer resistance to fluoroquinolone antibiotics. Cacn_gyrA_FLO antibiotic_resistance ARO:3003974 Cutibacterium acnes gyrA conferring resistance to fluoroquinolones Point mutations in Cutibacterium acnes gyrA protein known to confer resistance to fluoroquinolone antibiotics. PMID:27793740 Cacn_gyrA_FLO Antibiotic produced by Streptomyces pactum, considered a universal translation inhibitor. pubchem.compound:5289124 antibiotic_resistance ARO:3003975 pactamycin Antibiotic produced by Streptomyces pactum, considered a universal translation inhibitor. PMID:9398510 Point mutations in bacterial 16S rRNA that confer resistance to antibiotic pactamycin. antibiotic_resistance ARO:3003976 16S rRNA with mutation conferring resistance to pactamycin Point mutations in bacterial 16S rRNA that confer resistance to antibiotic pactamycin. PMID:9398510 Point mutations in Halobacterium 16S rRNA that confer resistance to pactamycin antibiotic. Hsal_16S_PAC antibiotic_resistance ARO:3003977 Halobacterium salinarum 16S rRNA mutation conferring resistance to pactamycin Point mutations in Halobacterium 16S rRNA that confer resistance to pactamycin antibiotic. PMID:9398510 Hsal_16S_PAC Point mutation in C. reinhardtii rrnS conferring resistance to streptomycin antibiotic. Crei_16rrnS_STR antibiotic_resistance ARO:3003978 Chlamydomonas reinhardtii 16S rRNA (rrnS) mutation conferring resistance to streptomycin Point mutation in C. reinhardtii rrnS conferring resistance to streptomycin antibiotic. PMID:2583478 Crei_16rrnS_STR A fluorocycline that acts to inhibit the bacterial ribosome. pubchem.compound:54726192 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline TP-434 antibiotic_resistance ARO:3003979 Eravacycline A fluorocycline that acts to inhibit the bacterial ribosome. PMID:23979750 TetA(58) is a Tetracycline efflux pump described in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. tetA(58) antibiotic_resistance ARO:3003980 tetA(58) TetA(58) is a Tetracycline efflux pump described in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. PMID:27929110 tetA(58) Tetracycline resistant TetB(58) efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. tetB(58) antibiotic_resistance ARO:3003981 tetB(58) Tetracycline resistant TetB(58) efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. PMID:27929110 tetB(58) Lincosamide (Clindamycin) resistant (putative) ribosomal methyltransferase related to the RlmK 23S rRNA methyltransferase COG family. Detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus found in Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. LlmA_23S_CLI antibiotic_resistance ARO:3003982 LlmA 23S ribosomal RNA methyltransferase Lincosamide (Clindamycin) resistant (putative) ribosomal methyltransferase related to the RlmK 23S rRNA methyltransferase COG family. Detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus found in Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. PMID:27929110 LlmA_23S_CLI Chloramphenicol acetyltransferase conferring resistance to phenicol antibiotics detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. CatU antibiotic_resistance ARO:3003983 CatU Chloramphenicol acetyltransferase conferring resistance to phenicol antibiotics detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. PMID:27929110 CatU Bacitracin amidohydrolase found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Confers resistance by bacitracin inactivation through amidohydrolysis. Described by Pawlowski et al. 2016. BahA antibiotic_resistance ARO:3003984 BahA Bacitracin amidohydrolase found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Confers resistance by bacitracin inactivation through amidohydrolysis. Described by Pawlowski et al. 2016. PMID:27929110 BahA Hydrolysis of amido side-chain of asparagine-12 forming hydrogen bond with undecaprenyl pyrophosphate in bacitracin leading to antibiotic inactivation. antibiotic_resistance ARO:3003985 amidohydrolysis of bacitracin undecaprenyl pyrophosphate Pleuromutilin (Tiamulin) ABC efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to pleuromutilin antibiotics. Described by Pawlowski et al. 2016. TaeA antibiotic_resistance ARO:3003986 TaeA Pleuromutilin (Tiamulin) ABC efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to pleuromutilin antibiotics. Described by Pawlowski et al. 2016. PMID:27929110 TaeA Streptogramin A acetyltransferase found in Paenibacillus sp. LC231, isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin A antibiotics. Described by Pawlowski et al. 2016. VatI antibiotic_resistance ARO:3003987 VatI Streptogramin A acetyltransferase found in Paenibacillus sp. LC231, isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin A antibiotics. Described by Pawlowski et al. 2016. PMID:27929110 VatI AAC(2')-IIb is an intrinsic Kasugamycin 2' acetyltransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to aminoglycoside antibiotics, including kasugamycin. Described by Pawlowski et al. 2016. AAC(2')-IIb antibiotic_resistance ARO:3003988 AAC(2')-IIb AAC(2')-IIb is an intrinsic Kasugamycin 2' acetyltransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to aminoglycoside antibiotics, including kasugamycin. Described by Pawlowski et al. 2016. PMID:27929110 AAC(2')-IIb AAC(6')-34 is an aminoglycoside 6'-phosphotransferase found in Paenibacillus sp. LC231, a strain of Paenibacillus from Lechuguilla Cave, NM, USA. Confers resistance to aminoglycoside antibiotics. Described by Pawlowski et al. 2016. AAC(6')-34 antibiotic_resistance ARO:3003989 AAC(6')-34 AAC(6')-34 is an aminoglycoside 6'-phosphotransferase found in Paenibacillus sp. LC231, a strain of Paenibacillus from Lechuguilla Cave, NM, USA. Confers resistance to aminoglycoside antibiotics. Described by Pawlowski et al. 2016. PMID:27929110 AAC(6')-34 VgbC is a streptogramin B-type lyase found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin B-type antibiotics by linearization of the lactone ring on an ester bond, resulting in antibiotic inactivation. Described by Pawlowski et al. 2016. vgbC antibiotic_resistance ARO:3003990 vgbC VgbC is a streptogramin B-type lyase found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin B-type antibiotics by linearization of the lactone ring on an ester bond, resulting in antibiotic inactivation. Described by Pawlowski et al. 2016. PMID:27929110 vgbC mphI is a macrolide phosphotransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to macrolide antibiotics. Described by Pawlowski et al. 2016. mphI antibiotic_resistance ARO:3003991 mphI mphI is a macrolide phosphotransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to macrolide antibiotics. Described by Pawlowski et al. 2016. PMID:27929110 PMID:29317655 mphI rphB is a rifampin phosphotransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to rifamycin antibiotics, specifically rifampin, through rifampin inactivation. Described by Pawlowski et al. 2016. rphB antibiotic_resistance ARO:3003992 rphB rphB is a rifampin phosphotransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to rifamycin antibiotics, specifically rifampin, through rifampin inactivation. Described by Pawlowski et al. 2016. PMID:27929110 rphB Capreomycin is an aminoglycoside antibiotic, capable of treating a large number of infections but in particular used for killing bacteria causing tuberculosis. pubchem.compound:122130878 antibiotic_resistance ARO:3003993 capreomycin Capreomycin is an aminoglycoside antibiotic, capable of treating a large number of infections but in particular used for killing bacteria causing tuberculosis. PMID:73540 cpaA is a capreomycin acetyltransferase protein found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus in Lechuguilla Cave, NM, USA. Confers resistance to capreomycin, an aminoglycoside antibiotic. Described by Pawlowski et al. 2016. cpaA antibiotic_resistance ARO:3003994 cpaA cpaA is a capreomycin acetyltransferase protein found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus in Lechuguilla Cave, NM, USA. Confers resistance to capreomycin, an aminoglycoside antibiotic. Described by Pawlowski et al. 2016. PMID:27929110 cpaA Amino acid substitutions in Clostridioides difficile gyrase subunit A which when present confer functional resistance to fluoroquinolone antibiotics. Cdif_gyrA_FLO antibiotic_resistance ARO:3003995 Clostridioides difficile gyrA conferring resistance to fluoroquinolones Amino acid substitutions in Clostridioides difficile gyrase subunit A which when present confer functional resistance to fluoroquinolone antibiotics. PMID:11451695 PMID:12384345 PMID:12848728 PMID:18480338 PMID:19364867 PMID:19818865 PMID:20226332 PMID:22508299 PMID:27842877 Cdif_gyrA_FLO An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate). pubchem.compound:23665637 AMC amoxicillin-clavulanate clavamox co-amoxiclav antibiotic_resistance ARO:3003997 amoxicillin-clavulanic acid An antibiotic mixture containing the penicillin-derived beta-lactam antibiotic Ampicillin and the beta-lactamase inhibitor Sulbactam. Also known as Unasyn and/or Ampictam. Ampictam SAM Unasyn antibiotic_resistance ARO:3003998 ampicillin-sulbactam Cefamandole is a second-generation cephalosporin-class beta-lactam antibiotic. pubchem.compound:456255 FAM antibiotic_resistance ARO:3003999 cefamandole Cefetamet is a third-generation semi-synthetic beta-lactam antibiotic that inactivates inner cell wall PBPs through targeting binding, resulting in cell lysis. pubchem.compound:5487888 FET cefetametum antibiotic_resistance ARO:3004000 cefetamet Cefetamet is a third-generation semi-synthetic beta-lactam antibiotic that inactivates inner cell wall PBPs through targeting binding, resulting in cell lysis. PMID:2504597 Cefmetazole is a semi-synthetic cephamycin antibiotic with broad spectrum antibiotic activity against both gram-positive and gram-negative bacteria, that disrupt cell wall synthesis through binding to PBPs causing cell lysis. pubchem.compound:42008 CMZ antibiotic_resistance ARO:3004001 cefmetazole Cefonicid is a second-generation cephalosporin-class beta-lactam antibiotic with broad spectrum activity. Particularly used against urinary tract infections and lower respiratory infections. Causes cell lysis by inactivation of PBPs through binding, inhibiting peptidoglycan synthesis. pubchem.compound:43594 CID cefonicide antibiotic_resistance ARO:3004002 cefonicid Cefoperazone is a semi-synthetic cephalosporin containing a tetrazolyl moiety that is resistant to beta-lactamases. Particularly used for treatment of Pseudomonas spp. infections. pubchem.compound:44187 CFP cefoperazine antibiotic_resistance ARO:3004003 cefoperazone Cefoperazone is a semi-synthetic cephalosporin containing a tetrazolyl moiety that is resistant to beta-lactamases. Particularly used for treatment of Pseudomonas spp. infections. PMID:6221381 Cefotetan is a cephamycin-class beta-lactam antibiotic that is highly resistant to beta-lactamases and effective against a wide range of gram-negative and gram-positive bacteria. pubchem.compound:53025 CTT Cefotetanum antibiotic_resistance ARO:3004004 cefotetan Cefprozil is a cephalosporin and beta-lactam antibiotic with bactericidal activity. It selectively binds to PBPs and inhibits peptidoglycan synthesis, a major cell wall component, resulting in cell lysis. pubchem.compound:5281006 Brisoral CPR Cefzil antibiotic_resistance ARO:3004005 cefprozil Cefprozil is a cephalosporin and beta-lactam antibiotic with bactericidal activity. It selectively binds to PBPs and inhibits peptidoglycan synthesis, a major cell wall component, resulting in cell lysis. PMID:12841400 Ceftiofur is a third-generation broad spectrum cephalosporin and beta-lactam antibiotic. It causes cell lysis by disrupting peptidoglycan cross-linkage and cell wall formation by binding to PBPs. pubchem.compound:6328657 Excenel Naxcel antibiotic_resistance ARO:3004006 ceftiofur Ceftiofur is a third-generation broad spectrum cephalosporin and beta-lactam antibiotic. It causes cell lysis by disrupting peptidoglycan cross-linkage and cell wall formation by binding to PBPs. PMID:3631686 Ceftizoxime is a third-generation cephalosporin and broad spectrum beta-lactam antibiotic. Ceftizoxime causes bacterial cell lysis through peptidoglycan cross-linking inhibition by binding to PBPs. pubchem.compound:6533629 ZOX antibiotic_resistance ARO:3004007 ceftizoxime Ceftizoxime is a third-generation cephalosporin and broad spectrum beta-lactam antibiotic. Ceftizoxime causes bacterial cell lysis through peptidoglycan cross-linking inhibition by binding to PBPs. PMID:6326062 Cephapirin is a first-generation cephalosporin and broad spectrum beta-lactam antibiotic. Inactivation of penicillin-binding proteins through cephapirin binding disrupts peptidoglycan cross-linking, resulting in cell lysis. pubchem.compound:30699 HAP cefadyl cefapirin antibiotic_resistance ARO:3004008 cephapirin Cefradine is a first-generation cephalosporin and broad spectrum beta-lactam antibiotic. Cefradine binding to penicillin-binding proteins disrupts cell wall peptidoglycan cross-linkage, resulting in cell lysis. pubchem.compound:38103 Cephradine RAD antibiotic_resistance ARO:3004009 cefradine Cefradine is a first-generation cephalosporin and broad spectrum beta-lactam antibiotic. Cefradine binding to penicillin-binding proteins disrupts cell wall peptidoglycan cross-linkage, resulting in cell lysis. PMID:4572639 Cinoxacin is a fluoroquinolone antibiotic primarily used for the treatment of urinary tract infections in adults. Cinoxacin binds to DNA gyrase, resulting in double-stranded DNA breaks and cell death. pubchem.compound:2762 Azolinic acid CIN antibiotic_resistance ARO:3004010 cinoxacin Cinoxacin is a fluoroquinolone antibiotic primarily used for the treatment of urinary tract infections in adults. Cinoxacin binds to DNA gyrase, resulting in double-stranded DNA breaks and cell death. PMID:7017171 Clinafloxacin is a fluoroquinolone antibiotic and gyrase (DNA topoisomerase II) inhibitor. It binds to DNA gyrase and disrupts replication by causing double-stranded DNA breaks, resulting in cell death. pubchem.compound:60063 CLX antibiotic_resistance ARO:3004011 clinafloxacin Clinafloxacin is a fluoroquinolone antibiotic and gyrase (DNA topoisomerase II) inhibitor. It binds to DNA gyrase and disrupts replication by causing double-stranded DNA breaks, resulting in cell death. PMID:3142350 Clofazimine is a fluoroquinolone-class phenazine dye used for the treatment of leprosy. Clofazimine binds to DNA and disrupts bacterial DNA gyrase, thereby causing double-stranded DNA breaks, and subsequent cell death. pubchem.compound:2794 Lampren Lamprene antibiotic_resistance ARO:3004012 clofazimine Clofazimine is a fluoroquinolone-class phenazine dye used for the treatment of leprosy. Clofazimine binds to DNA and disrupts bacterial DNA gyrase, thereby causing double-stranded DNA breaks, and subsequent cell death. PMID:7829710 Fleroxacin is a broad spectrum fluoroquinolone antibiotic that inhibits the DNA supercoiling activity of bacterial DNA gyrase, resulting in double-stranded DNA breaks and subsequent cell death. pubchem.compound:3357 Megalocin Quinodis antibiotic_resistance ARO:3004013 fleroxacin Fleroxacin is a broad spectrum fluoroquinolone antibiotic that inhibits the DNA supercoiling activity of bacterial DNA gyrase, resulting in double-stranded DNA breaks and subsequent cell death. PMID:2112571 Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria. pubchem.compound:65864 antibiotic_resistance ARO:3004014 flomoxef Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria. PMID:37610203 PMID:4008339 Gentamicin A is part of a complex of broad spectrum aminoglycoside antibiotics. Gentamicin inhibits protein synthesis, resulting in bacterial cell death. pubchem.compound:12810388 Garamycin antibiotic_resistance ARO:3004015 gentamicin A Gentamicin A is part of a complex of broad spectrum aminoglycoside antibiotics. Gentamicin inhibits protein synthesis, resulting in bacterial cell death. PMID:10103173 PMID:11083623 Loracarbef is a second-generation cephalosporin (carbacephem) and broad spectrum beta-lactam antibiotic. Loracarbef inhibits PBPs through binding, disrupting peptidoglycan cell wall cross-linkage and resulting in cell death. pubchem.compound:5284585 Lorabid Loracarbefum antibiotic_resistance ARO:3004016 loracarbef Loracarbef is a second-generation cephalosporin (carbacephem) and broad spectrum beta-lactam antibiotic. Loracarbef inhibits PBPs through binding, disrupting peptidoglycan cell wall cross-linkage and resulting in cell death. PMID:3501757 PMID:8453172 Moxalactam (Latamoxef) is a broad spectrum cephalosporin (oxacephem) and beta-lactam antibiotic. Moxalactam binding to PBPs inhibits peptidoglycan cross-linkage in the cell wall, resulting in cell death. Moxalactam is proposed to be effective against meningitides as it passes the blood-brain barrier. pubchem.compound:47499 Latamoxef antibiotic_resistance ARO:3004017 moxalactam Moxalactam (Latamoxef) is a broad spectrum cephalosporin (oxacephem) and beta-lactam antibiotic. Moxalactam binding to PBPs inhibits peptidoglycan cross-linkage in the cell wall, resulting in cell death. Moxalactam is proposed to be effective against meningitides as it passes the blood-brain barrier. PMID:315938 PMID:6218558 Nafcillin is a penicillin-class narrow-spectrum beta-lactam antibiotic. It inhibits cell wall synthesis and peptidoglycan cross-linkage through binding to PBPs, similarly to other penicillin-like antibiotics. pubchem.compound:8982 Nafcil antibiotic_resistance ARO:3004018 nafcillin Para-aminosalicylic acid (PAS) is an anti-tubercular antibiotic agent, often used in conjunction with Isoniazid for treatment of M. tuberculosis infections. PAS diminishes bacterial cell growth by limiting folic acid production. pubchem.compound:4649 4-aminosalicylic acid antibiotic_resistance ARO:3004019 para-aminosalicylic acid An antibiotic cocktail containing the beta-lactam penam antibiotic Piperacillin and the beta-lactamase inhibitor sulbactam. antibiotic_resistance ARO:3004020 piperacillin-sulbactam An antibiotic cocktail containing the penam beta-lactam antibiotic Piperacillin and the beta-lactamase inhibitor Tazobactam. pubchem.compound:23724843 Tazocin Zosyn antibiotic_resistance ARO:3004021 piperacillin-tazobactam An antibiotic cocktail of the streptogramin A dalfopristin and the streptogramin B quinupristin antibiotics. Used particularly to treat MRSA and vancomycin-resistant Enterococcus. pubchem.compound:25199981 Synercid antibiotic_resistance ARO:3004022 quinupristin-dalfopristin An antibiotic cocktail containing the beta-lactam antibiotic ticarcillin and the beta-lactamase inhibitor clavulanic acid (clavulanate). pubchem.compound:6437075 co-ticarclav antibiotic_resistance ARO:3004023 ticarcillin-clavulanic acid An antibiotic cocktail containing the diaminopyrimidine antibiotic Trimethoprim and the sulfonamide antibiotic sulfamethoxazole (1 TMP:5 SMX). pubchem.compound:358641 cotrimoxazole antibiotic_resistance ARO:3004024 trimethoprim-sulfamethoxazole Prothionamide is a thioamide derivative with antibacterial properties. It increases cell wall permeability and decreases cell wall damage resistance by inhibition of mycolic acid synthesis, resulting in cell death. It is particularly used to treat M. tuberculosis and M. leprae infections. pubchem.compound:666418 protionamide antibiotic_resistance ARO:3004025 prothionamide Prothionamide is a thioamide derivative with antibacterial properties. It increases cell wall permeability and decreases cell wall damage resistance by inhibition of mycolic acid synthesis, resulting in cell death. It is particularly used to treat M. tuberculosis and M. leprae infections. PMID:6459296 Tinidazole is a nitroimidazole anti-parasitic drug. It is used in the treatment of protozoan infections. pubchem.compound:5479 Fasigyn Simplotan Sporinex Tindamax antibiotic_resistance ARO:3004026 tinidazole Tinidazole is a nitroimidazole anti-parasitic drug. It is used in the treatment of protozoan infections. PMID:3733593 An efflux pump/potassium antiporter system (RosAB) formed by the RosA and RosB proteins found in Yersinia. antibiotic_resistance ARO:3004030 RosAB An efflux pump/potassium antiporter system (RosAB) formed by the RosA and RosB proteins found in Yersinia. PMID:10931306 PMID:12010497 tetAB(46) is a heterodimeric ABC transporter conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. Both tetA(46) and tetB(46) genes are required for resistance. antibiotic_resistance ARO:3004031 tetAB(46) tetAB(46) is a heterodimeric ABC transporter conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. Both tetA(46) and tetB(46) genes are required for resistance. PMID:22941900 tetA(46) is a subunit of tetAB(46), a heterodimeric ABC transporter, that is required for conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. tetA(46) antibiotic_resistance ARO:3004032 tetA(46) tetA(46) is a subunit of tetAB(46), a heterodimeric ABC transporter, that is required for conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. PMID:22941900 tetA(46) tetB(46) is a subunit of tetAB(46), a heterodimeric ABC transporter, that is required for conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. tetB(46) antibiotic_resistance ARO:3004033 tetB(46) tetB(46) is a subunit of tetAB(46), a heterodimeric ABC transporter, that is required for conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. PMID:22941900 tetB(46) tetAB(60) is an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli. Both tetA(60) and tetB(60) are required for resistance. antibiotic_resistance ARO:3004034 tetAB(60) tetAB(60) is an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli. Both tetA(60) and tetB(60) are required for resistance. PMID:27999567 tetA(60) is a subunit of tetAB(60), an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli, which is required for resistance. tetA(60) antibiotic_resistance ARO:3004035 tetA(60) tetA(60) is a subunit of tetAB(60), an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli, which is required for resistance. PMID:27999567 tetA(60) tetB(60) is a subunit of tetAB(60), an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli, which is required for resistance. tetB(60) antibiotic_resistance ARO:3004036 tetB(60) tetB(60) is a subunit of tetAB(60), an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli, which is required for resistance. PMID:27999567 tetB(60) EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. Confers resistance to tetraphenylphosphonium, methyl viologen, gentamicin, kanamycin, and neomycin. PDB:3B61 PAsmr Pae-Emre Paer_emrE antibiotic_resistance ARO:3004038 Pseudomonas aeruginosa emrE EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. Confers resistance to tetraphenylphosphonium, methyl viologen, gentamicin, kanamycin, and neomycin. PMID:12499164 Paer_emrE Member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation. PDB:3B61 Ecol_emrE antibiotic_resistance ARO:3004039 Escherichia coli emrE Member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation. PMID:1936950 Ecol_emrE Enzymes, protein or other gene products that inactivate rifampin (rifamycin) antibiotics through phosphorylation of the antibiotic at the 21-OH position. rph antibiotic_resistance ARO:3004040 rifampin phosphotransferase AcrA is a subunit of the AcrAB multidrug efflux system that is found in K. pneumoniae, which is encoded by the acrRAB operon. PDB:2F1M Kpne_acrA antibiotic_resistance ARO:3004041 Klebsiella pneumoniae acrA AcrA is a subunit of the AcrAB multidrug efflux system that is found in K. pneumoniae, which is encoded by the acrRAB operon. PMID:19858254 PMID:24327941 Kpne_acrA AcrA is a subunit of the AcrAB-TolC multidrug efflux system in E. cloacae. PDB:2F1M Eclo_acrA antibiotic_resistance ARO:3004042 Enterobacter cloacae acrA AcrA is a subunit of the AcrAB-TolC multidrug efflux system in E. cloacae. PMID:12121946 PMID:17536927 Eclo_acrA AcrA is a subunit of the AcrAB-TolC multidrug efflux system found in E. coli. PDB:2F1M Ecol_acrA antibiotic_resistance ARO:3004043 Escherichia coli acrA AcrA is a subunit of the AcrAB-TolC multidrug efflux system found in E. coli. PMID:11321576 PMID:12363006 PMID:24747401 Ecol_acrA fabI is a bacterial enoyl-acyl carrier reductase (ENR) isozyme. As with other ENRs, mutations in fabI can confer resistance to the biocide triclosan. antibiotic_resistance ARO:3004044 antibiotic sensitive fabI fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid. Ecol_fabI_MULT antibiotic_resistance ARO:3004045 Escherichia coli fabI mutations conferring resistance to isoniazid and triclosan fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid. PMID:27577999 Ecol_fabI_MULT kdpDE is a two-component regulatory system in Escherichia coli, well studied for its role in potassium transport and homeostasis. kdpE is also implicated in virulence loci regulation and overexpression of kdpE is shown to confer resistance to aminoglycoside antibiotics. antibiotic_resistance ARO:3004046 kdpDE kdpDE is a two-component regulatory system in Escherichia coli, well studied for its role in potassium transport and homeostasis. kdpE is also implicated in virulence loci regulation and overexpression of kdpE is shown to confer resistance to aminoglycoside antibiotics. PMID:23555240 kdpD is a component of the two-component regulatory system, kdpDE. This system is involved in potassium transport and homeostasis, and has been implicated in virulence factor regulation along with kdpE. kdpD antibiotic_resistance ARO:3004047 kdpD kdpD is a component of the two-component regulatory system, kdpDE. This system is involved in potassium transport and homeostasis, and has been implicated in virulence factor regulation along with kdpE. PMID:23555240 kdpD MexAB-OprM efflux pump system with a prematurely terminated MexR confers resistance to meropenem and ciprofloxacin. Paer_tMexR_MULT antibiotic_resistance ARO:3004048 MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin MexAB-OprM efflux pump system with a prematurely terminated MexR confers resistance to meropenem and ciprofloxacin. PMID:26866484 Paer_tMexR_MULT fabG is a 3-oxoacyl-acyl carrier protein reductase involved in lipid metabolism and fatty acid biosynthesis.The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabG can confer resistance to Triclosan. Ecol_fabG_TRC antibiotic_resistance ARO:3004049 Escherichia coli fabG mutations conferring resistance to triclosan fabG is a 3-oxoacyl-acyl carrier protein reductase involved in lipid metabolism and fatty acid biosynthesis.The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabG can confer resistance to Triclosan. PMID:27577999 Ecol_fabG_TRC fabG is a bacterial 3-oxoacyl enoyl-acyl carrier reductase (ENR) isozyme. As with other ENRs, mutations in fabG are shown to confer resistance to the biocide triclosan. antibiotic_resistance ARO:3004050 antibiotic sensitive fabG fabG is a bacterial 3-oxoacyl enoyl-acyl carrier reductase (ENR) isozyme. As with other ENRs, mutations in fabG are shown to confer resistance to the biocide triclosan. PMID:27577999 MexAB-OprM efflux pump system with NalC mutations conferring resistance to aztreonam. While efflux gene hyperexpression typically results from mutations in the linked mexR repressor gene, it also occurs independently of mexR mutations in so-called nalC mutants that demonstrate more modest mexAB-oprM expression and, thus, more modest multidrug resistance than do mexR strains. Paer_NalC_ATM antibiotic_resistance ARO:3004051 MexAB-OprM with NalC mutations conferring resistance to aztreonam MexAB-OprM efflux pump system with NalC mutations conferring resistance to aztreonam. While efflux gene hyperexpression typically results from mutations in the linked mexR repressor gene, it also occurs independently of mexR mutations in so-called nalC mutants that demonstrate more modest mexAB-oprM expression and, thus, more modest multidrug resistance than do mexR strains. PMID:15387820 PMID:27412168 Paer_NalC_ATM MexAB-OprM efflux pump system with a NalD mutation conferring resistance to multiple antibiotics. This NalD mutation was found in multidrug-resistant clinical strains lacking mutations in MexR or NalC. Paer_NalD_MULT antibiotic_resistance ARO:3004052 MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics MexAB-OprM efflux pump system with a NalD mutation conferring resistance to multiple antibiotics. This NalD mutation was found in multidrug-resistant clinical strains lacking mutations in MexR or NalC. PMID:15855496 Paer_NalD_MULT CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. Paer_CpxR_MULT antibiotic_resistance ARO:3004053 MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. PMID:27736975 Paer_CpxR_MULT CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. Paer_CpxR antibiotic_resistance ARO:3004054 Pseudomonas aeruginosa CpxR CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. PMID:27736975 Paer_CpxR The Escherichia coli CpxR/CpxA system responds to general periplasmic stress and has been used as a model two-component system for transcription regulation in bacteria. CpxR/CpxA system facilitates Salmonella and E. coli resistance to cationic antimicrobial peptides.The CpxR/CpxA system can activate transcription of marRAB operon, thus facilitating multidrug-resistant regulator to enhance expression of TolC-dependent tripartite multidrug transporters. Ecol_CpxR antibiotic_resistance ARO:3004055 Escherichia coli CpxR The Escherichia coli CpxR/CpxA system responds to general periplasmic stress and has been used as a model two-component system for transcription regulation in bacteria. CpxR/CpxA system facilitates Salmonella and E. coli resistance to cationic antimicrobial peptides.The CpxR/CpxA system can activate transcription of marRAB operon, thus facilitating multidrug-resistant regulator to enhance expression of TolC-dependent tripartite multidrug transporters. PMID:25294881 Ecol_CpxR ArmR, a 53-amino-acid antirepressor, allosterically inhibits MexR dimer-DNA binding by occupying a hydrophobic binding cavity within the center of the MexR dimer. ArmR up-regulation and MexR-ArmR complex formation have previously been shown to upregulate MexAB-OprM. ArmR antibiotic_resistance ARO:3004056 ArmR ArmR, a 53-amino-acid antirepressor, allosterically inhibits MexR dimer-DNA binding by occupying a hydrophobic binding cavity within the center of the MexR dimer. ArmR up-regulation and MexR-ArmR complex formation have previously been shown to upregulate MexAB-OprM. PMID:17545281 PMID:18812515 ArmR Point mutations in the 23S rRNA subunit may confer resistance to linezolid and other oxazolidinone antibiotics. antibiotic_resistance ARO:3004057 23S rRNA with mutation conferring resistance to linezolid antibiotics Point mutations in the 23S rRNA subunit may confer resistance to linezolid and other oxazolidinone antibiotics. PMID:27727405 Point mutations in the 23S rRNA subunit of the large ribosomal bacterial subunit in Staphylococcus aureus, which confer resistance to linezolid by disrupting antibiotic target binding. Saur_23S_LZD antibiotic_resistance ARO:3004058 Staphylococcus aureus 23S rRNA with mutation conferring resistance to linezolid Point mutations in the 23S rRNA subunit of the large ribosomal bacterial subunit in Staphylococcus aureus, which confer resistance to linezolid by disrupting antibiotic target binding. PMID:27727405 Saur_23S_LZD Type A NfxB mutants are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1. nfxB corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: esrC/nfxB) and 2 loci in Pseudomonas aeruginosa LESB58 (gene name: nfxB). Type_A_NfxB esrC antibiotic_resistance ARO:3004059 Type A NfxB Type A NfxB mutants are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1. nfxB corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: esrC/nfxB) and 2 loci in Pseudomonas aeruginosa LESB58 (gene name: nfxB). PMID:8849250 Type_A_NfxB Type B NfxB mutants are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1. The mutation at the 46th amino acid position is sufficient for overproduction of OprJ and the multidrug resistance. nfxB corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: esrC/nfxB) and 2 loci in Pseudomonas aeruginosa LESB58 (gene name: nfxB). Type_B_NfxB esrC antibiotic_resistance ARO:3004060 Type B NfxB Type B NfxB mutants are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1. The mutation at the 46th amino acid position is sufficient for overproduction of OprJ and the multidrug resistance. nfxB corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: esrC/nfxB) and 2 loci in Pseudomonas aeruginosa LESB58 (gene name: nfxB). PMID:8849250 PMID:9449262 Type_B_NfxB MexCD–OprJ with type A NfxB phenotype are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1. Paer_NfxBa_MULT antibiotic_resistance ARO:3004061 MexCD-OprJ with type A NfxB mutation MexCD–OprJ with type A NfxB phenotype are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1. PMID:8849250 Paer_NfxBa_MULT MexCD-OprJ with Type B NfxB mutions are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1. Paer_NfxBb_MULT antibiotic_resistance ARO:3004062 MexCD-OprJ with type B NfxB mutation MexCD-OprJ with Type B NfxB mutions are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1. PMID:8849250 Paer_NfxBb_MULT EdeQ is an N-acetyltransferase enzyme that confers high-level self-resistance to edeine in Brevibacillus brevis, a natural edeine producer. EdeQ converts active edeine to N-acetyledeine, which is ineffective in vivo. EdeQ antibiotic_resistance ARO:3004063 EdeQ EdeQ is an N-acetyltransferase enzyme that confers high-level self-resistance to edeine in Brevibacillus brevis, a natural edeine producer. EdeQ converts active edeine to N-acetyledeine, which is ineffective in vivo. PMID:23891151 EdeQ Edeine acetyltransferase enzymes catalyze the transfer of an acetyl group to active edeine, converting it to an inactive form in vivo. This mechanism is used for high-level self-resistance in edeine-producing Brevibacillus spp. antibiotic_resistance ARO:3004064 Edeine acetyltransferase Edeine acetyltransferase enzymes catalyze the transfer of an acetyl group to active edeine, converting it to an inactive form in vivo. This mechanism is used for high-level self-resistance in edeine-producing Brevibacillus spp. PMID:23891151 The MexEF–OprN efflux pump in P. aeruginosa is overexpressed with MexT mutation conferring resistance to chloramphenicol and ciprofloxacin. Paer_MexT_MULT antibiotic_resistance ARO:3004066 MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim The MexEF–OprN efflux pump in P. aeruginosa is overexpressed with MexT mutation conferring resistance to chloramphenicol and ciprofloxacin. PMID:26833155 Paer_MexT_MULT Subclass B1 (metallo-) beta-lactamases found in Myroides spp., which confer resistance to carbapenam class beta-lactamase antibiotics. antibiotic_resistance ARO:3004067 MUS beta-lactamase The MexEF–OprN efflux pump with MexS mutations conferring resistance to chloramphenicol and ciprofloxacin. The model includes the MexT regulator, as MexS is suggested to inactivate MexT. Paer_MexS_MULT antibiotic_resistance ARO:3004068 MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim The MexEF–OprN efflux pump with MexS mutations conferring resistance to chloramphenicol and ciprofloxacin. The model includes the MexT regulator, as MexS is suggested to inactivate MexT. PMID:26833155 Paer_MexS_MULT MvaT, a global regulator of virulence genes in P. aeruginosa, has also shown to be able to repress the expression of the MexEF-OprN pump. MvaT antibiotic_resistance ARO:3004069 MvaT MvaT, a global regulator of virulence genes in P. aeruginosa, has also shown to be able to repress the expression of the MexEF-OprN pump. PMID:16448502 MvaT A deletion of MvaT results in the overexpression of MexEF-OprN conferring resistance to chloramphenicol and norfloxacin. Paer_MvaT_MULT antibiotic_resistance ARO:3004070 MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin A deletion of MvaT results in the overexpression of MexEF-OprN conferring resistance to chloramphenicol and norfloxacin. PMID:16448502 PMID:21911574 Paer_MvaT_MULT OpmB is an outer membrane efflux protein in Pseudomonas aeruginosa that shows functional cooperation with MuxABC, to form the efflux pump system MuxABC-OpmB. OpmB PA2525 antibiotic_resistance ARO:3004072 OpmB OpmB is an outer membrane efflux protein in Pseudomonas aeruginosa that shows functional cooperation with MuxABC, to form the efflux pump system MuxABC-OpmB. PMID:12445646 OpmB MuxA is a membrane fusion protein component of the efflux pump system MuxABC-OpmB in Pseudomonas aeruginosa. MuxA PA2528 antibiotic_resistance ARO:3004073 MuxA MuxA is a membrane fusion protein component of the efflux pump system MuxABC-OpmB in Pseudomonas aeruginosa. PMID:19713238 MuxA MuxB is one of the two necessary RND components in the Pseudomonas aeruginosa efflux pump system MuxABC-OpmB. MuxB PA2527 antibiotic_resistance ARO:3004074 MuxB MuxB is one of the two necessary RND components in the Pseudomonas aeruginosa efflux pump system MuxABC-OpmB. PMID:19713238 MuxB MuxC is one of the two necessary RND components of the MuxABC-OpmB efflux pumps system in Pseudomonas aeruginosa. MuxC PA2526 antibiotic_resistance ARO:3004075 MuxC MuxC is one of the two necessary RND components of the MuxABC-OpmB efflux pumps system in Pseudomonas aeruginosa. PMID:19713238 MuxC MuxABC-OpmB is an RND-type multidrug efflux pump in Pseudomonas aeruginosa. This efflux pump confers resistance to aztreonam, novobiocin, tetracycline, erythromycin, kitasamycin and rokitamycin. MuxABC-OpmB antibiotic_resistance ARO:3004076 MuxABC-OpmB MuxABC-OpmB is an RND-type multidrug efflux pump in Pseudomonas aeruginosa. This efflux pump confers resistance to aztreonam, novobiocin, tetracycline, erythromycin, kitasamycin and rokitamycin. PMID:19713238 MuxABC-OpmB PmpM is a multidrug efflux pump belonging to the MATE family of Pseudomonas aeruginosa. PmpM is an H+ drug antiporter and is the first reported case of an H+ coupled efflux pump in the MATE family. PmpM confers resistance to fluoroquinolones, fradiomycin, benzalkonium chloride, chlorhexidine gluconate, ethidium bromide, tetraphenylphosphonium chloride (TPPCl), and rhodamine 6G. PA1361 PmpM antibiotic_resistance ARO:3004077 PmpM PmpM is a multidrug efflux pump belonging to the MATE family of Pseudomonas aeruginosa. PmpM is an H+ drug antiporter and is the first reported case of an H+ coupled efflux pump in the MATE family. PmpM confers resistance to fluoroquinolones, fradiomycin, benzalkonium chloride, chlorhexidine gluconate, ethidium bromide, tetraphenylphosphonium chloride (TPPCl), and rhodamine 6G. PMID:14679249 PmpM MexAB-OprM efflux pump system with MexR mutations confers resistance to multiple antibiotics in P. aeruginosa. Paer_MexR_MULT antibiotic_resistance ARO:3004080 MexAB-OprM with MexR mutations confers resistance to multiple antibiotics MexAB-OprM efflux pump system with MexR mutations confers resistance to multiple antibiotics in P. aeruginosa. PMID:17586626 PMID:9449262 Paer_MexR_MULT AcrAD-TolC efflux pump system in E. coli from the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. AcrAD-TolC antibiotic_resistance ARO:3004082 AcrAD-TolC AcrAD-TolC efflux pump system in E. coli from the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. PMID:10692383 PMID:14706082 AcrAD-TolC AcrEF-TolC efflux pump system of E. coli confers resistance to fluoroquinolones (ciprofloxacin). AcrEF_TolC_CIP antibiotic_resistance ARO:3004083 AcrEF-TolC confers resistance to ciprofloxacin AcrEF-TolC efflux pump system of E. coli confers resistance to fluoroquinolones (ciprofloxacin). PMID:10952561 PMID:16267305 AcrEF_TolC_CIP lnuG is a transposon-mediated lincosamide nucleotidyltransferase found in Enterococcus faecalis on Tn6260. lnuG antibiotic_resistance ARO:3004085 lnuG lnuG is a transposon-mediated lincosamide nucleotidyltransferase found in Enterococcus faecalis on Tn6260. PMID:28039271 lnuG APH(3')-VIIIb is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides found in Acinetobacter rudis. APH(3')-VIIIb antibiotic_resistance ARO:3004086 APH(3')-VIIIb APH(3')-VIIIb is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides found in Acinetobacter rudis. PMID:27965516 APH(3')-VIIIb APH(3')-IXa is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides. APH(3')-IXa antibiotic_resistance ARO:3004087 APH(3')-IXa APH(3')-IXa is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides. PMID:27965516 APH(3')-IXa Lefamulin is a semi-synthetic pleuromutilin compound highly active against multi-resistant pathogens. pubchem.compound:25185057 antibiotic_resistance ARO:3004088 lefamulin Lefamulin is a semi-synthetic pleuromutilin compound highly active against multi-resistant pathogens. PMID:27958389 PMID:32493034 ANT(3'')-IIa is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms. ANT(3'')-IIa ANT(9)(3'') aadA1-pm antibiotic_resistance ARO:3004089 ANT(3'')-IIa ANT(3'')-IIa is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms. PMID:28152054 ANT(3'')-IIa ANT(3'')-IIb is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms. ANT(3'')-IIb antibiotic_resistance ARO:3004090 ANT(3'')-IIb ANT(3'')-IIb is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms. PMID:28152054 ANT(3'')-IIb ANT(3'')-IIc is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms. ANT(3'')-IIc antibiotic_resistance ARO:3004091 ANT(3'')-IIc ANT(3'')-IIc is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms. PMID:28152054 ANT(3'')-IIc Shotgun cloning of beta-lactam resistant P. aeruginosa NRZ-03096 yielded a clone producing a novel subclass B1 enzyme with only 74.3% identity to the next nearest relative, KHM-1. The novel MBL was named HMB-1 (for Hamburg MBL). HMB-1 gene was chromosomally located as part of a Tn 3 family transposon that was named Tn 6345, where expression of bla HMB-1 in E. coli TOP10 led to increased resistance to beta-lactams. HMB-1 antibiotic_resistance ARO:3004092 HMB-1 Shotgun cloning of beta-lactam resistant P. aeruginosa NRZ-03096 yielded a clone producing a novel subclass B1 enzyme with only 74.3% identity to the next nearest relative, KHM-1. The novel MBL was named HMB-1 (for Hamburg MBL). HMB-1 gene was chromosomally located as part of a Tn 3 family transposon that was named Tn 6345, where expression of bla HMB-1 in E. coli TOP10 led to increased resistance to beta-lactams. PMID:28065891 HMB-1 NDM-17 is a metallo-beta-lactamase isolated from Escherichia coli with enhanced carbapenemase activity compared to NDM-1. NDM-17 antibiotic_resistance ARO:3004093 NDM-17 NDM-17 is a metallo-beta-lactamase isolated from Escherichia coli with enhanced carbapenemase activity compared to NDM-1. PMID:28242668 NDM-17 Erm(48) is a macrolide-lincosamide-streptogramin resistance gene identified on resistance plasmid pJW2311. Erm(48) antibiotic_resistance ARO:3004094 Erm(48) Erm(48) is a macrolide-lincosamide-streptogramin resistance gene identified on resistance plasmid pJW2311. PMID:28438941 Erm(48) Mutations to the CdsA phosphatidate cytidylyltransferase conferring resistance to daptomycin. antibiotic_resistance ARO:3004096 daptomycin resistant CdsA Mutations to the CdsA phosphatidate cytidylyltransferase conferring resistance to daptomycin. PMID:28115347 CdsA is a phosphatidate cytidylyltransferase which plays a role in the production of membrane phosphatidylglycerol and cardiolipin. Smit_CdsA_DAP antibiotic_resistance ARO:3004097 Streptococcus mitis CdsA with mutation conferring daptomycin resistance CdsA is a phosphatidate cytidylyltransferase which plays a role in the production of membrane phosphatidylglycerol and cardiolipin. PMID:28115347 Smit_CdsA_DAP LpeAB are components of an efflux pump, which is a macrolide resistance determinant in L. pneumophila Paris strain. Mutations observed in the upstream sequence of lpeAB operon in resistant lineages led to an overexpression of this efflux pump. Sub-inhibitory concentrations of macrolides themselves participated in upregulating this efflux and could constitute a first step in the acquisition of a high macrolide resistance level. As Lpp2879–Lpp2880 is homologous to Escherichia coli AcrAB, lpp2879–lpp2880 was renamed to lpeAB. lpp2879-lpp2880 antibiotic_resistance ARO:3004098 LpeAB LpeAB are components of an efflux pump, which is a macrolide resistance determinant in L. pneumophila Paris strain. Mutations observed in the upstream sequence of lpeAB operon in resistant lineages led to an overexpression of this efflux pump. Sub-inhibitory concentrations of macrolides themselves participated in upregulating this efflux and could constitute a first step in the acquisition of a high macrolide resistance level. As Lpp2879–Lpp2880 is homologous to Escherichia coli AcrAB, lpp2879–lpp2880 was renamed to lpeAB. PMID:28137939 LpeA is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrA in E. coli. LpeA lpp2879 antibiotic_resistance ARO:3004099 LpeA LpeA is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrA in E. coli. PMID:28137939 LpeA LpeB is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrB in E. coli. LpeB lpp2880 antibiotic_resistance ARO:3004100 LpeB LpeB is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrB in E. coli. PMID:28137939 LpeB MdtNOP is a MFS efflux pump protein found in E. coli. The deletion of mdtP from strain W3110 resulted in increased susceptibility to acriflavin, puromycin, and tetraphenylarsonium chloride. An E. coli mdtN null mutant is more sensitive to sulfur drugs than wild type. MdtNOP sdsRQP ycjRQP antibiotic_resistance ARO:3004101 MdtNOP MdtNOP is a MFS efflux pump protein found in E. coli. The deletion of mdtP from strain W3110 resulted in increased susceptibility to acriflavin, puromycin, and tetraphenylarsonium chloride. An E. coli mdtN null mutant is more sensitive to sulfur drugs than wild type. PMID:19429622 PMID:8021163 MdtNOP Methyltransferase enzyme first described in Streptoalloteichus tenebrarius. Confers resistance to aminoglycoside antibiotics (esp. apramycin) through methylation of the 16S rRNA at A1408, thereby modifying the antibiotic target. kamB antibiotic_resistance ARO:3004102 kamB Methyltransferase enzyme first described in Streptoalloteichus tenebrarius. Confers resistance to aminoglycoside antibiotics (esp. apramycin) through methylation of the 16S rRNA at A1408, thereby modifying the antibiotic target. PMID:19589804 PMID:24963996 kamB QepA2 is a plasmid-mediated quinolone resistance pump found in an Escherichia coli isolate from France. QepA2 antibiotic_resistance ARO:3004103 QepA2 QepA2 is a plasmid-mediated quinolone resistance pump found in an Escherichia coli isolate from France. PMID:18644958 QepA2 TMB-1, the first known member of the Tripoli metallo-beta-lactamase family (TMB) was isolated from Achromobacter xylosoxidans in a Tripoli central hospital. TMB-1 was located on a class 1 integron and is a chromosomally-encoded beta-lactamase capable of hydrolyzing multiple antibiotics. antibiotic_resistance ARO:3004104 TMB beta-lactamase TMB-1, the first known member of the Tripoli metallo-beta-lactamase family (TMB) was isolated from Achromobacter xylosoxidans in a Tripoli central hospital. TMB-1 was located on a class 1 integron and is a chromosomally-encoded beta-lactamase capable of hydrolyzing multiple antibiotics. PMID:22290947 TMB-1 is a TMB metallo-beta-lactamase found in Achromobacter sp. TMB-1 antibiotic_resistance ARO:3004105 TMB-1 TMB-1 is a TMB metallo-beta-lactamase found in Achromobacter sp. PMID:22290947 TMB-1 TMB-2 is a TMB metallo-beta-lactamase found in Acinetobacter sp. TMB-2 antibiotic_resistance ARO:3004106 TMB-2 TMB-2 is a TMB metallo-beta-lactamase found in Acinetobacter sp. PMID:23390208 TMB-2 SoxR is a redox-sensitive transcriptional activator that induces expression of a small regulon that includes the RND efflux pump-encoding operon mexGHI-opmD. SoxR was shown to be activated by pyocyanin. Paer_soxR antibiotic_resistance ARO:3004107 Pseudomonas aeruginosa soxR SoxR is a redox-sensitive transcriptional activator that induces expression of a small regulon that includes the RND efflux pump-encoding operon mexGHI-opmD. SoxR was shown to be activated by pyocyanin. PMID:15845502 PMID:16879411 PMID:27274079 Paer_soxR rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. Eclo_rob robA antibiotic_resistance ARO:3004108 Enterobacter cloacae rob rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. PMID:23006750 Eclo_rob rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. Ecol_rob robA antibiotic_resistance ARO:3004109 Escherichia coli rob rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. PMID:12791142 PMID:9324261 Ecol_rob MCR-2 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting in reduction of the negative charge of the cell membrane. Originally identified in a Belgian sample of Escherichia coli by Xavier et al, (2016). MCR-2 MCR-2.1 antibiotic_resistance ARO:3004110 MCR-2.1 MCR-2 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting in reduction of the negative charge of the cell membrane. Originally identified in a Belgian sample of Escherichia coli by Xavier et al, (2016). PMID:27416987 PMID:28487432 PMID:30053115 MCR-2.1 FosA6 is a plasmid-encoded enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. FosA6 antibiotic_resistance ARO:3004111 FosA6 FosA6 is a plasmid-encoded enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. PMID:27261267 FosA6 This group of enzymes catalyzes the addition of a phosphoethanolamine group to another molecule. The addition of this moiety to lipid A in bacterial species is often associated with polymyxin (otherwise known as colistin) resistance. PEtN transferase antibiotic_resistance ARO:3004112 phosphoethanolamine transferase conferring colistin resistance This group of enzymes catalyzes the addition of a phosphoethanolamine group to another molecule. The addition of this moiety to lipid A in bacterial species is often associated with polymyxin (otherwise known as colistin) resistance. PMID:26603172 PMID:28487432 FosA7 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. FosA7 antibiotic_resistance ARO:3004113 FosA7 FosA7 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. PMID:28533247 FosA7 In the presence of antibiotic stress, there is a coupled down-regulation of the porin OmpC with the OmpF. Mutants both lacking both OmpC and OmpF proteins are resistant to cephaloridine and cefazolin. Analyses of genes involved in the increased resistance to tetracycline suggest that the up-regulation of efflux pump genes is accompanied by a decrease of OmpF and OmpC synthesis. Homologs of OmpC have been identified in Escherichia coli, Salmonella enterica, Klebsiella aerogenes and Serratia marcescens. porin_OmpC antibiotic_resistance ARO:3004114 porin OmpC In the presence of antibiotic stress, there is a coupled down-regulation of the porin OmpC with the OmpF. Mutants both lacking both OmpC and OmpF proteins are resistant to cephaloridine and cefazolin. Analyses of genes involved in the increased resistance to tetracycline suggest that the up-regulation of efflux pump genes is accompanied by a decrease of OmpF and OmpC synthesis. Homologs of OmpC have been identified in Escherichia coli, Salmonella enterica, Klebsiella aerogenes and Serratia marcescens. PMID:17426813 PMID:23034325 PMID:6760806 porin_OmpC Nitroimidazoles are a group of drugs that have both antiprotozoal and antibacterial activity, classified with respect to the location of the nitro functional group. antibiotic_resistance ARO:3004115 nitroimidazole antibiotic Nitrofurans are chemotherapeutic agents with antibacterial and antiprotozoal activity. antibiotic_resistance ARO:3004116 nitrofuran antibiotic A ToxR-Regulated outer membrane porin. In Vibrio cholerae, ToxR controls resistance to P2 (a BPI-derived antimicrobial peptide) by regulating the production of OmpU. OmpU also confers resistance to polymyxin B sulfate. Vcho_OmpU antibiotic_resistance ARO:3004117 Vibrio cholerae OmpU A ToxR-Regulated outer membrane porin. In Vibrio cholerae, ToxR controls resistance to P2 (a BPI-derived antimicrobial peptide) by regulating the production of OmpU. OmpU also confers resistance to polymyxin B sulfate. PMID:15155667 PMID:24943244 Vcho_OmpU A ToxR negatively regulated outer membrane porin. In Vibrio cholerae, ToxR controls resistance to P2 (a BPI-derived antimicrobial peptide) by regulating the production of OmpT, especially in the absence of OmpU. Vcho_OmpT antibiotic_resistance ARO:3004118 Vibrio cholerae OmpT A ToxR negatively regulated outer membrane porin. In Vibrio cholerae, ToxR controls resistance to P2 (a BPI-derived antimicrobial peptide) by regulating the production of OmpT, especially in the absence of OmpU. PMID:10632889 PMID:15155667 Vcho_OmpT CBP C1-aminomethylene vancomycin is a synthetic vancomycin derivative which exhibits multiple synergistic mechanisms of action, allowing it to effectively inhibit otherwise-glycopeptide resistant Gram-positive bacteria (notably those with functioning VanA clusters). antibiotic_resistance ARO:3004120 CBP C1-aminomethylene vancomycin CBP C1-aminomethylene vancomycin is a synthetic vancomycin derivative which exhibits multiple synergistic mechanisms of action, allowing it to effectively inhibit otherwise-glycopeptide resistant Gram-positive bacteria (notably those with functioning VanA clusters). PMID:28559345 Bactericidal/permeability-increasing (BPI) protein is a member of a new generation of proteins known as super-antibiotics that are implicated as endotoxin neutralising agents. The potent (nM) cytotoxicity of BPI is limited to gram-negative bacteria (GNB), reflecting the high affinity (<10 nM) of BPI for bacterial lipopolysaccharides (LPS). Binding of BPI to live bacteria via LPS causes immediate growth arrest, actual killing coincides with later damage to the inner membrane. PDB:1EWF antibiotic_resistance ARO:3004121 BPI Bactericidal/permeability-increasing (BPI) protein is a member of a new generation of proteins known as super-antibiotics that are implicated as endotoxin neutralising agents. The potent (nM) cytotoxicity of BPI is limited to gram-negative bacteria (GNB), reflecting the high affinity (<10 nM) of BPI for bacterial lipopolysaccharides (LPS). Binding of BPI to live bacteria via LPS causes immediate growth arrest, actual killing coincides with later damage to the inner membrane. PMID:28336464 PMID:9665269 Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35. Kpne_OmpK37 antibiotic_resistance ARO:3004122 Klebsiella pneumoniae OmpK37 Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35. PMID:10217760 Kpne_OmpK37 Heterologous expression of Burkholderia pseudomallei Omp38 (BpsOmp38) in Omp-deficient E. coli host cells lowers their permeability and in consequence, their antimicrobial susceptibility to penicillin G, cefoxitin, ceftazidime and imipenem. Bpse_Omp38 antibiotic_resistance ARO:3004123 Burkholderia pseudomallei Omp38 Heterologous expression of Burkholderia pseudomallei Omp38 (BpsOmp38) in Omp-deficient E. coli host cells lowers their permeability and in consequence, their antimicrobial susceptibility to penicillin G, cefoxitin, ceftazidime and imipenem. PMID:14567756 PMID:24788109 Bpse_Omp38 The outer membrane protein M35 of Moraxella catarrhalis is an antigenically conserved porin. Down-regulation of M35 significantly increases the MICs of aminopenicillins, specifically amoxicillin. Mcat_M35_AMX antibiotic_resistance ARO:3004124 Moraxella catarrhalis M35 The outer membrane protein M35 of Moraxella catarrhalis is an antigenically conserved porin. Down-regulation of M35 significantly increases the MICs of aminopenicillins, specifically amoxicillin. PMID:16159786 PMID:20801781 Mcat_M35_AMX Nucleotide point mutations in the 23S rRNA subunit may confer resistance to macrolide antibiotics. antibiotic_resistance ARO:3004125 23S rRNA with mutation conferring resistance to macrolide antibiotics Nucleotide point mutations in the 23S rRNA subunit may confer resistance to macrolide antibiotics. PMID:11120937 LamB is a negative regulator for antibiotic resistance, it serves as a porin to influx antibiotic. When down-regulated, it increases resistance to chlortetracycline, ciprofloxacin, balofloxacin and nalidixic acid. It also interacts with Odp1, an energy metabolic enzyme, creating a complex that decreases in antibiotic-resistant strains. Ecol_LamB antibiotic_resistance ARO:3004126 Escherichia coli LamB LamB is a negative regulator for antibiotic resistance, it serves as a porin to influx antibiotic. When down-regulated, it increases resistance to chlortetracycline, ciprofloxacin, balofloxacin and nalidixic acid. It also interacts with Odp1, an energy metabolic enzyme, creating a complex that decreases in antibiotic-resistant strains. PMID:10734605 PMID:18620846 PMID:24412198 Ecol_LamB MltA-interacting protein (mipA), is an antibiotic resistance-related outer membrane protein. Deletion of mipA increases kanamycin, nalidixic acid and streptomycin resistance. Ecol_mipA antibiotic_resistance ARO:3004127 Escherichia coli mipA MltA-interacting protein (mipA), is an antibiotic resistance-related outer membrane protein. Deletion of mipA increases kanamycin, nalidixic acid and streptomycin resistance. PMID:25940639 Ecol_mipA Omp1 is an outer membrane porin that confers resistance by absence in S. marcescens. Knockout, deletion or other inhibition of the omp1 gene confers resistance to certain beta-lactamase antibiotics - including Cefoxitin, Ceftriaxone, Cefotaxime, and Moxalactam - as well as Ciprofloxacin, Tetracycline, and Chloramphenicol, by preventing passage of the antibiotic into the cell. Smar_Omp1 antibiotic_resistance ARO:3004128 Serratia marcescens Omp1 Omp1 is an outer membrane porin that confers resistance by absence in S. marcescens. Knockout, deletion or other inhibition of the omp1 gene confers resistance to certain beta-lactamase antibiotics - including Cefoxitin, Ceftriaxone, Cefotaxime, and Moxalactam - as well as Ciprofloxacin, Tetracycline, and Chloramphenicol, by preventing passage of the antibiotic into the cell. PMID:25856195 PMID:9353750 Smar_Omp1 Cephaloridine is a semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity. Cephaloridine binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. pubchem.compound:5773 Cefaloridin Cefaloridine Cefalorizin Cephalomycine Cephaloridin Cephaloridinum Ceporin antibiotic_resistance ARO:3004129 cephaloridine Cephaloridine is a semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity. Cephaloridine binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. PMID:2907014 PMID:5175748 Balofloxacin is an 8-methoxy fluoroquinolone antibiotic. It shows potent bactericidal activity and inhibits the supercoiling activity of DNA gyrase of S. aureus, E. coli, and P. aeruginosa. pubchem.compound:65958 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylaminopiperidine-1-yl)-4-oxoquinoline-3-carboxylic acid Q 35 Q-35 antibiotic_resistance ARO:3004130 balofloxacin Balofloxacin is an 8-methoxy fluoroquinolone antibiotic. It shows potent bactericidal activity and inhibits the supercoiling activity of DNA gyrase of S. aureus, E. coli, and P. aeruginosa. PMID:1329626 PMID:7492097 Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to the macrolide-class antibiotics erythromycin and telithromycin. Ecol_23S_MULT antibiotic_resistance ARO:3004131 Escherichia coli 23S rRNA with mutation conferring resistance to erythromycin and telithromycin Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to the macrolide-class antibiotics erythromycin and telithromycin. PMID:10027979 PMID:11120937 PMID:1569089 PMID:3886627 PMID:6330677 Ecol_23S_MULT Point mutation in 23S rRNA of C. reinhardtii chloroplast shown clinically to confer resistance to Erythromycin, a macrolide antibiotic. Crei_23S_ERY antibiotic_resistance ARO:3004132 Chlamydomonas reinhardtii 23S rRNA with mutation conferring resistance to erythromycin Point mutation in 23S rRNA of C. reinhardtii chloroplast shown clinically to confer resistance to Erythromycin, a macrolide antibiotic. PMID:11120937 PMID:2583478 Crei_23S_ERY Point mutation in B. hyodysenteriae 23S rRNA shown to confer resistance to tylosin and erythromycin. Bhyo_23S_TYL antibiotic_resistance ARO:3004133 Brachyspira hyodysenteriae 23S rRNA with mutation conferring resistance to tylosin Point mutation in B. hyodysenteriae 23S rRNA shown to confer resistance to tylosin and erythromycin. PMID:11120937 Bhyo_23S_TYL Point mutations in Helicobacter pylori shown to confer resistance to clarithromycin, a macrolide antibiotic. Hpyl_23S_CLR antibiotic_resistance ARO:3004134 Helicobacter pylori 23S rRNA with mutation conferring resistance to clarithromycin Point mutations in Helicobacter pylori shown to confer resistance to clarithromycin, a macrolide antibiotic. PMID:11120937 PMID:32708761 PMID:35002447 PMID:37485536 Hpyl_23S_CLR Point mutations in M. tuberculosis iniB shown to confer resistance to ethambutol. Mtub_iniB_EMB antibiotic_resistance ARO:3004135 Mycobacterium tuberculosis iniB with mutation conferring resistance to ethambutol Point mutations in M. tuberculosis iniB shown to confer resistance to ethambutol. PMID:10639358 Mtub_iniB_EMB Point mutations occurring in the iniB region of the iniBAC operon shown to confer resistance to ethambutol. antibiotic_resistance ARO:3004136 Ethambutol resistant iniB Point mutations occurring in the iniB region of the iniBAC operon shown to confer resistance to ethambutol. PMID:10639358 iniB, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell. antibiotic_resistance ARO:3004137 Antibiotic resistant iniB Point mutations in the 23S ribosomal RNA subunit of M. catarrhalis shown clinically to confer resistance to macrolide class antibiotics. Mcat_23S_MAC antibiotic_resistance ARO:3004138 Moraxella catarrhalis 23S rRNA with mutation conferring resistance to macrolide antibiotics Point mutations in the 23S ribosomal RNA subunit of M. catarrhalis shown clinically to confer resistance to macrolide class antibiotics. PMID:25923017 Mcat_23S_MAC MCR-3 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting reduction in negative charge of the cell membrane. Originally described by Yin et al. 2017, from a porcine Escherichia coli plasmid pWJ1. MCR-3.1 antibiotic_resistance ARO:3004139 MCR-3.1 MCR-3 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting reduction in negative charge of the cell membrane. Originally described by Yin et al. 2017, from a porcine Escherichia coli plasmid pWJ1. PMID:28655818 MCR-3.1 Enzymes shown to inactivate fusidic acid by hydrolytic cleavage from the 16 beta-position of fusidic acid and its derivatives. This converts fusidic acid to an inactivate lactone derivative, thus conferring resistance to fusidic acid. antibiotic_resistance ARO:3004140 hydrolysis of fusidic acid to inactive lactone derivative An RND-type efflux system that confers innate aminoglycoside resistance to Achromobacter spp. It has a transcriptional regulator encoded by the axyZ gene located upstream of axyXY-oprZ. In-frame axyZ gene deletion assay led to increased MICs of antibiotic substrates of the efflux system: aminoglycosides, cefepime, fluoroquinolones, tetracyclines and erythromycin, indicating that the product of axyZ negatively regulates expression of axyXY-oprZ. Moreover a 45 amino-acid substitution at position 29 of AxyZ (V29G) was identified in a clinical Achromobacter strain that occurred during the course of chronic respiratory tract colonization in a cystic fibrosis (CF) patient. This substitution, also detected in 3 other strains exposed in vitro to tobramycin, led to the increase in axyY transcription level (5 to 17-fold) together with the increase in antibiotic resistance level. antibiotic_resistance ARO:3004141 AxyXY-OprZ An RND-type efflux system that confers innate aminoglycoside resistance to Achromobacter spp. It has a transcriptional regulator encoded by the axyZ gene located upstream of axyXY-oprZ. In-frame axyZ gene deletion assay led to increased MICs of antibiotic substrates of the efflux system: aminoglycosides, cefepime, fluoroquinolones, tetracyclines and erythromycin, indicating that the product of axyZ negatively regulates expression of axyXY-oprZ. Moreover a 45 amino-acid substitution at position 29 of AxyZ (V29G) was identified in a clinical Achromobacter strain that occurred during the course of chronic respiratory tract colonization in a cystic fibrosis (CF) patient. This substitution, also detected in 3 other strains exposed in vitro to tobramycin, led to the increase in axyY transcription level (5 to 17-fold) together with the increase in antibiotic resistance level. PMID:28584156 OprZ is the outer membrane component of the AxyXY-OprZ efflux pump system in Achromobacter spp. OprZ antibiotic_resistance ARO:3004142 OprZ OprZ is the outer membrane component of the AxyXY-OprZ efflux pump system in Achromobacter spp. PMID:28584156 OprZ AxyX is the inner membrane transporter of the AxyXY-OprZ efflux pump system in Achromobacter spp. AxyX antibiotic_resistance ARO:3004143 AxyX AxyX is the inner membrane transporter of the AxyXY-OprZ efflux pump system in Achromobacter spp. PMID:28584156 AxyX AxyY is the periplasmic adaptor protein of the AxyXY-OprZ efflux pump system in Achromobacter spp. AxyY antibiotic_resistance ARO:3004144 AxyY AxyY is the periplasmic adaptor protein of the AxyXY-OprZ efflux pump system in Achromobacter spp. PMID:28584156 AxyY AxyZ is a transcriptional regulator of the AxyXY-OprZ efflux pump system. AxyZ antibiotic_resistance ARO:3004145 AxyZ AxyZ is a transcriptional regulator of the AxyXY-OprZ efflux pump system. PMID:28584156 AxyZ A cfr-like 23S rRNA methyltransferase shown to confer resistance to linezolid and phenicol antibiotics, including florfenicol and chloramphenicol, in Clostridium. cfr(C) cfrC antibiotic_resistance ARO:3004146 cfrC A cfr-like 23S rRNA methyltransferase shown to confer resistance to linezolid and phenicol antibiotics, including florfenicol and chloramphenicol, in Clostridium. PMID:28663118 cfrC Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clindamycin, a lincosamide antibiotic. Ecol_23S_CLI antibiotic_resistance ARO:3004149 Escherichia coli 23S rRNA with mutation conferring resistance to clindamycin Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clindamycin, a lincosamide antibiotic. PMID:1531223 Ecol_23S_CLI Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to chloramphenicol. Ecol_23S_CHL antibiotic_resistance ARO:3004150 Escherichia coli 23S rRNA with mutation conferring resistance to chloramphenicol Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to chloramphenicol. PMID:3886627 Ecol_23S_CHL Antibiotic resistant form of thymidylate synthase (synthetase), an enzyme that catalyzes the conversion of dUMP to dTMP in nucleotide biosynthesis. Loss-of-function mutations in thymidylate synthase confer resistance to p-aminosalicylic acid by disrupting the substrate-binding affinity and catalytic activity. antibiotic_resistance ARO:3004152 aminosalicylate resistant thymidylate synthase Point mutations in the thymidylate synthetase thyA gene shown clinically to confer resistance to para-aminosalicylic acid. Loss-of-function mutations in thyA disrupt the catalytic activity and substrate-binding affinity, thus conferring resistance. Mtub_thyA_PAS antibiotic_resistance ARO:3004153 Mycobacterium tuberculosis thyA with mutation conferring resistance to para-aminosalicylic acid Point mutations in the thymidylate synthetase thyA gene shown clinically to confer resistance to para-aminosalicylic acid. Loss-of-function mutations in thyA disrupt the catalytic activity and substrate-binding affinity, thus conferring resistance. PMID:25421465 Mtub_thyA_PAS Thymidylate synthase (synthetase) catalyzes the conversion of dUMP to dTMP in the nucleic acid biosynthesis pathway. Inhibition of thyA imbalances the cellular concentration of dUMP causing DNA damage. antibiotic sensitive thyA antibiotic_resistance ARO:3004154 antibiotic sensitive thymidylate synthase Thymidylate synthase (synthetase) catalyzes the conversion of dUMP to dTMP in the nucleic acid biosynthesis pathway. Inhibition of thyA imbalances the cellular concentration of dUMP causing DNA damage. PMID:25421465 Dihydrofolate synthase (synthetase) enzymes resistant to aminosalicylates (inc. para-aminosalicylic acid) caused by mutation. Dihydrofolate synthase is required for bioactivation of p-aminosalicylic acid, and mutation in dihydrofolate synthase inhibits production of the dihydrofolate analog hydroxyl-dihydrofolate, thus preventing activation and conferring resistance. antibiotic_resistance ARO:3004155 aminosalicylate resistant dihydrofolate synthase Wild-type form of dihydrofolate synthase (synthetase) enzymes. Bioactivation of p-aminosalicylic acid occurs during the folate pathway when dihydrofolate and its analog hydroxyl-dihydrofolate are produced by dihydrofolate synthase. Disruption of this pathway by PAS results in cell damage and death. antibiotic_resistance ARO:3004156 antibiotic sensitive dihydrofolate synthase Point mutations in the dihydrofolate synthetase folC gene shown clinically to confer resistance to p-aminosalicylic acid or other aminosalicylates. Mutations in folC inhibit bioactivation of PAS and thus confer resistance. Mtub_folC_PAS antibiotic_resistance ARO:3004157 Mycobacterium tuberculosis folC with mutation conferring resistance to para-aminosalicylic acid Point mutations in the dihydrofolate synthetase folC gene shown clinically to confer resistance to p-aminosalicylic acid or other aminosalicylates. Mutations in folC inhibit bioactivation of PAS and thus confer resistance. PMID:25421465 Mtub_folC_PAS Point mutations in the 23S rRNA (domain V) of Mycoplasma gallisepticum can confer resistance to pleuromutilin antibiotics (tiamulin and valnemulin). The mutants also show cross-resistance to lincomycin, chloramphenicol and florfenicol. Mgal_23S_PLM antibiotic_resistance ARO:3004159 Mycoplasma gallisepticum 23S rRNA mutation conferring resistance to pleuromutilin antibiotics Point mutations in the 23S rRNA (domain V) of Mycoplasma gallisepticum can confer resistance to pleuromutilin antibiotics (tiamulin and valnemulin). The mutants also show cross-resistance to lincomycin, chloramphenicol and florfenicol. PMID:19154331 PMID:20487023 Mgal_23S_PLM Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clarithromycin, a macrolide antibiotic. Ecol_23S_CLR antibiotic_resistance ARO:3004160 Escherichia coli 23S rRNA with mutation conferring resistance to clarithromycin Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clarithromycin, a macrolide antibiotic. PMID:1531223 Ecol_23S_CLR Point mutation in the 23S rRNA of Propionibacteria shown clinically to confer resistance to macrolides. Prop_23S_MAC antibiotic_resistance ARO:3004161 Propionibacteria 23S rRNA with mutation conferring resistance to macrolide antibiotics Point mutation in the 23S rRNA of Propionibacteria shown clinically to confer resistance to macrolides. PMID:9145890 Prop_23S_MAC Point mutation in the 23S rRNA of Mycobacteroides abscessus shown to confer resistance to clarithromycin, a macrolide type antibiotic. Mabs_23S_CLR antibiotic_resistance ARO:3004163 Mycobacteroides abscessus 23S rRNA with mutation conferring resistance to clarithromycin Point mutation in the 23S rRNA of Mycobacteroides abscessus shown to confer resistance to clarithromycin, a macrolide type antibiotic. PMID:27799212 PMID:8807061 Mabs_23S_CLR Point mutation in the 23S rRNA of Mycobacterium avium shown to confer resistance to clarithromycin, a macrolide type antibiotic. Mavi_23S_CLR antibiotic_resistance ARO:3004164 Mycobacterium avium 23S rRNA with mutation conferring resistance to clarithromycin Point mutation in the 23S rRNA of Mycobacterium avium shown to confer resistance to clarithromycin, a macrolide type antibiotic. PMID:8592991 Mavi_23S_CLR Point mutation in the 23S rRNA of Mycobacteroides chelonae shown to confer resistance to clarithromycin, a macrolide type antibiotic. Mche_23S_CLR antibiotic_resistance ARO:3004165 Mycobacteroides chelonae 23S rRNA with mutation conferring resistance to clarithromycin Point mutation in the 23S rRNA of Mycobacteroides chelonae shown to confer resistance to clarithromycin, a macrolide type antibiotic. PMID:11120937 Mche_23S_CLR Point mutation in the 23S rRNA of Mycobacterium intracellulare shown to confer resistance to clarithromycin, a macrolide type antibiotic. Mint_23S_CLR antibiotic_resistance ARO:3004166 Mycobacterium intracellulare 23S rRNA with mutation conferring resistance to clarithromycin Point mutation in the 23S rRNA of Mycobacterium intracellulare shown to confer resistance to clarithromycin, a macrolide type antibiotic. PMID:8192472 Mint_23S_CLR Point mutation in the 23S rRNA of Mycobaccterium avium shown to confer resistance to azithromycin, a macrolide type antibiotic. Mint_23S_AZM antibiotic_resistance ARO:3004167 Mycobacterium intracellulare 23S rRNA with mutation conferring resistance to azithromycin Point mutation in the 23S rRNA of Mycobaccterium avium shown to confer resistance to azithromycin, a macrolide type antibiotic. PMID:8192472 Mint_23S_AZM Point mutation in the 23S rRNA of Mycobacterium kansasii shown to confer resistance to clarithromycin, a macrolide type antibiotic. Mkan_23S_CLR antibiotic_resistance ARO:3004168 Mycobacterium kansasii 23S rRNA with mutation conferring resistance to clarithromycin Point mutation in the 23S rRNA of Mycobacterium kansasii shown to confer resistance to clarithromycin, a macrolide type antibiotic. PMID:9635911 Mkan_23S_CLR Point mutation in the 23S rRNA of Mycolicibacterium smegmatis shown to confer resistance to clarithromycin, a macrolide type antibiotic. Msme_23S_CLR antibiotic_resistance ARO:3004169 Mycolicibacterium smegmatis 23S rRNA with mutation conferring resistance to clarithromycin Point mutation in the 23S rRNA of Mycolicibacterium smegmatis shown to confer resistance to clarithromycin, a macrolide type antibiotic. PMID:9402018 Msme_23S_CLR Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolide type antibiotics. Spne_23S_MAC antibiotic_resistance ARO:3004170 Streptococcus pneumoniae 23S rRNA with mutation conferring resistance to macrolide antibiotics Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolide type antibiotics. PMID:10898684 Spne_23S_MAC Point mutation in the 23S rRNA of Streptomyces ambofaciens shown to confer resistance to macrolide type antibiotics. Samb_23S_MAC antibiotic_resistance ARO:3004171 Streptomyces ambofaciens 23S rRNA with mutation conferring resistance to macrolide antibiotics Point mutation in the 23S rRNA of Streptomyces ambofaciens shown to confer resistance to macrolide type antibiotics. PMID:2834204 Samb_23S_MAC Point mutations in the 23S rRNA subunit may confer resistance to oxazolidinone antibiotics. antibiotic_resistance ARO:3004172 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics Point mutations in the 23S rRNA subunit may confer resistance to oxazolidinone antibiotics. PMID:10986233 Point mutation in the 23S rRNA of Escherichia coli shown to confer resistance to oxazolidinone type antibiotics. Ecol_23S_OXZ antibiotic_resistance ARO:3004173 Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics Point mutation in the 23S rRNA of Escherichia coli shown to confer resistance to oxazolidinone type antibiotics. PMID:10986233 Ecol_23S_OXZ Point mutation in the 23S rRNA of Chlamydia trachomatis shown to confer resistance to macrolide type antibiotics. Ctra_23S_MAC antibiotic_resistance ARO:3004174 Chlamydia trachomatis 23S rRNA with mutation conferring resistance to macrolide antibiotics Point mutation in the 23S rRNA of Chlamydia trachomatis shown to confer resistance to macrolide type antibiotics. PMID:15047540 PMID:17908942 PMID:26622462 Ctra_23S_MAC Point mutation in the 23S rRNA of Mycoplasma hominis shown to confer resistance to macrolide type antibiotics. Mhom_23S_MAC antibiotic_resistance ARO:3004176 Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics Point mutation in the 23S rRNA of Mycoplasma hominis shown to confer resistance to macrolide type antibiotics. PMID:12234836 Mhom_23S_MAC Point mutation in the 23S rRNA of Mycoplasmopsis fermentans shown to confer resistance to macrolide type antibiotics. Mfer_23S_MAC antibiotic_resistance ARO:3004177 Mycoplasmopsis fermentans 23S rRNA with mutation conferring resistance to macrolide antibiotics Point mutation in the 23S rRNA of Mycoplasmopsis fermentans shown to confer resistance to macrolide type antibiotics. PMID:12234836 Mfer_23S_MAC Point mutations in the 23S rRNA subunit may confer resistance to pleuromutilin antibiotics. antibiotic_resistance ARO:3004178 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics Point mutations in the 23S rRNA subunit may confer resistance to pleuromutilin antibiotics. PMID:19154331 PMID:20487023 Point mutation in the 23S rRNA of Mycoplasma pneumoniae shown to confer resistance to erythromycin. Mpne_23S_ERY antibiotic_resistance ARO:3004179 Mycoplasma pneumoniae 23S rRNA mutation conferring resistance to erythromycin Point mutation in the 23S rRNA of Mycoplasma pneumoniae shown to confer resistance to erythromycin. PMID:8593017 Mpne_23S_ERY Point mutation in the 23S rRNA of Halobacterium halobium shown to confer resistance to chloramphenicol. Hhal_23S_CHL antibiotic_resistance ARO:3004180 Halobacterium halobium 23S rRNA mutation conferring resistance to chloramphenicol Point mutation in the 23S rRNA of Halobacterium halobium shown to confer resistance to chloramphenicol. PMID:2045374 Hhal_23S_CHL Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolides and streptogramins types of antibiotics. Spne_23S_MULT antibiotic_resistance ARO:3004181 Streptococcus pneumoniae 23S rRNA mutation conferring resistance to macrolides and streptogramins antibiotics Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolides and streptogramins types of antibiotics. PMID:11120988 Spne_23S_MULT Nucleotide point mutations in the 23S rRNA subunit may confer resistance to streptogramins antibiotics. antibiotic_resistance ARO:3004182 23S rRNA with mutation conferring resistance to streptogramins antibiotics Nucleotide point mutations in the 23S rRNA subunit may confer resistance to streptogramins antibiotics. PMID:11120988 Antibiotic target replacement dihydrofolate reductase enzymes or domains with catalytic activity that confer resistance to aminosalicylates, esp. p-aminosalicylic acid. antibiotic_resistance ARO:3004183 aminosalicylate resistant dihydrofolate reductase ribD is a Mycobacterium tuberculosis riboflavin biosynthesis enzyme. Point mutations in ribD cause enzyme overexpression, which allows the C-terminal reductase domain to act as an alternative dihydrofolate reductase. Thus, mutations in ribD confer resistance to DHFR inhibitors such as para-aminosalicylic acid. Mtub_ribD_PAS antibiotic_resistance ARO:3004184 Mycobacterium tuberculosis ribD with mutation conferring resistance to para-aminosalicylic acid ribD is a Mycobacterium tuberculosis riboflavin biosynthesis enzyme. Point mutations in ribD cause enzyme overexpression, which allows the C-terminal reductase domain to act as an alternative dihydrofolate reductase. Thus, mutations in ribD confer resistance to DHFR inhibitors such as para-aminosalicylic acid. PMID:25421465 Mtub_ribD_PAS mecD is a PBP2a variant identified on a genomic resistance island in Macrococcus caseolyticus. MecD confers resistance to methicillin and other beta-lactam antibiotics through the production of an alternative low-affinity PBP. First described by Schwendener et al. 2017 and identified from canine and bovine sources. mecD antibiotic_resistance ARO:3004185 mecD mecD is a PBP2a variant identified on a genomic resistance island in Macrococcus caseolyticus. MecD confers resistance to methicillin and other beta-lactam antibiotics through the production of an alternative low-affinity PBP. First described by Schwendener et al. 2017 and identified from canine and bovine sources. PMID:28272476 mecD Point mutations in the 23S rRNA subunit may confer resistance to lincosamide antibiotics by reducing antibiotic binding-site affinity. antibiotic_resistance ARO:3004187 23S rRNA with mutation conferring resistance to lincosamide antibiotics Point mutations in the 23S rRNA subunit shown clinically to confer resistance to phenicol class antibiotics, including chloramphenicol and florfenicol, by disrupting antibiotic binding-site affinity. antibiotic_resistance ARO:3004188 23S rRNA with mutation conferring resistance to phenicol antibiotics Bla2 is a chromosomal-encoded beta-lactamase, found in Bacillus anthracis, which has penicillin, cephalosporin, and carbapenem-hydrolizing abilities. Bla2 antibiotic_resistance ARO:3004189 Bla2 Bla2 is a chromosomal-encoded beta-lactamase, found in Bacillus anthracis, which has penicillin, cephalosporin, and carbapenem-hydrolizing abilities. PMID:12533457 PMID:12760895 PMID:27557855 Bla2 BlaA beta-lactamases are Class A beta-lactamases first identified in Yersinia enterocolitica and have the ability to hydrolize penicilins and cephalosporins. antibiotic_resistance ARO:3004190 BlaA beta-lactamase BlaA beta-lactamases are Class A beta-lactamases first identified in Yersinia enterocolitica and have the ability to hydrolize penicilins and cephalosporins. PMID:11897607 PMID:16553870 PMID:1756974 PMID:237976 Aminoglycoside 2''-phosphotransferase identified from the gram-negative pathogen Campylobacter jejuni. APH(2'')-If was shown to confer resistance to 4,6-disubstituted antibiotics kanamycin, tobramycin, dibekacin, gentamicin and sisomicin through antibiotic phosphorylation. Described by Toth et al. 2013. APH(2'')-If antibiotic_resistance ARO:3004191 APH(2'')-If Aminoglycoside 2''-phosphotransferase identified from the gram-negative pathogen Campylobacter jejuni. APH(2'')-If was shown to confer resistance to 4,6-disubstituted antibiotics kanamycin, tobramycin, dibekacin, gentamicin and sisomicin through antibiotic phosphorylation. Described by Toth et al. 2013. PMID:23129050 APH(2'')-If CepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin. antibiotic_resistance ARO:3004192 CepA beta-lactamase CepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin. PMID:7517394 PMID:8285623 Sed beta-lactamases are Class A beta-lactamases that are capable of hydrolyzing benzypenicillin, cephalothin, and cloxacillin. antibiotic_resistance ARO:3004193 Sed beta-lactamase Sed beta-lactamases are Class A beta-lactamases that are capable of hydrolyzing benzypenicillin, cephalothin, and cloxacillin. PMID:7517394 A plasmid-borne novel MCR-1 functional variant detected in a Klebsiella pneumoniae isolate collected from a rectal swab in Italy. MCR-1.2 differs from MCR-1 by a single amino acid substitution from Glutamine to Leucine at position 3 in the N-terminal region. Described by DiPilato et al. 2016. MCR-1.2 antibiotic_resistance ARO:3004194 MCR-1.2 A plasmid-borne novel MCR-1 functional variant detected in a Klebsiella pneumoniae isolate collected from a rectal swab in Italy. MCR-1.2 differs from MCR-1 by a single amino acid substitution from Glutamine to Leucine at position 3 in the N-terminal region. Described by DiPilato et al. 2016. PMID:27401575 MCR-1.2 nmcA beta-lactamases are chromosomal-encoded Class A beta-lactamases first isolated from Enterobacter cloacae, specifically a clinical strain known as NOR-1. nmcA beta-lactamases have been shown to hydrolyze carbapenems. antibiotic_resistance ARO:3004195 NmcA beta-lactamase nmcA beta-lactamases are chromosomal-encoded Class A beta-lactamases first isolated from Enterobacter cloacae, specifically a clinical strain known as NOR-1. nmcA beta-lactamases have been shown to hydrolyze carbapenems. PMID:8052644 VCC beta-lactamases are Class A beta-lactamases. antibiotic_resistance ARO:3004196 VCC beta-lactamase VCC beta-lactamases are Class A beta-lactamases. PMID:26824956 BlaZ beta-lactamases are Class A beta-lactamases. These beta-lactamases are responsible for penicillin resistance in Staphylococcus aureus. antibiotic_resistance ARO:3004197 BlaZ beta-lactamase BlaZ beta-lactamases are Class A beta-lactamases. These beta-lactamases are responsible for penicillin resistance in Staphylococcus aureus. PMID:26305782 PMID:6793593 R39 beta-lactamases are Class A beta-lactamases encoded in Actinomadura R39 with the ability to hydrolyze penicillins. antibiotic_resistance ARO:3004198 R39 beta-lactamase R39 beta-lactamases are Class A beta-lactamases encoded in Actinomadura R39 with the ability to hydrolyze penicillins. PMID:2515104 CepS beta-lactamases are Class C beta-lactamases capable of hydrolyzing cephalosporin. antibiotic_resistance ARO:3004199 CepS beta-lactamase CepS beta-lactamases are Class C beta-lactamases capable of hydrolyzing cephalosporin. PMID:8537283 CfiA beta-lactamases are chromosomal-encoded carbapenemase commonly found in Bacteroides fragilis isolates. antibiotic_resistance ARO:3004200 CfiA beta-lactamase CfiA beta-lactamases are chromosomal-encoded carbapenemase commonly found in Bacteroides fragilis isolates. PMID:1510410 BlaB beta-lactamases are class B beta-lactamases that are found in a variety of species and have the ability to hydrolyze penams and carbapenems. antibiotic_resistance ARO:3004201 BlaB beta-lactamase JOHN beta-lactamases hydrolyse penicillins, narrow- and expanded-spectrum cephalosporins, and carbapenems. antibiotic_resistance ARO:3004202 JOHN beta-lactamase JOHN beta-lactamases hydrolyse penicillins, narrow- and expanded-spectrum cephalosporins, and carbapenems. PMID:12562690 CGB beta-lactamases are Class B beta-lactamases found in Chryseobacterium gleu that can hydrolyze penicillins; narrow- and expanded-spectrum cephalosporins; and carbapenems. antibiotic_resistance ARO:3004203 CGB beta-lactamase CGB beta-lactamases are Class B beta-lactamases found in Chryseobacterium gleu that can hydrolyze penicillins; narrow- and expanded-spectrum cephalosporins; and carbapenems. PMID:12183230 EBR beta-lactamases are Class B beta-lactamases first isolated from Empedobacter brevis and are able to hydrolyze penicillins, cephalosporins, and carbapenems. antibiotic_resistance ARO:3004204 EBR beta-lactamase EBR beta-lactamases are Class B beta-lactamases first isolated from Empedobacter brevis and are able to hydrolyze penicillins, cephalosporins, and carbapenems. PMID:12234848 TUS beta-lactamases are Class B beta-lactamases that can hydrolyze a variety of beta-lactams, such as cephems and carbapenems. antibiotic_resistance ARO:3004205 TUS beta-lactamase TUS beta-lactamases are Class B beta-lactamases that can hydrolyze a variety of beta-lactams, such as cephems and carbapenems. PMID:12384365 PMID:24031236 SIM beta-lactamases are Class B beta-lactamases that are capable of hydrolyzing a wide variety of beta-lactams, including penicillins, narrow- to expanded-spectrum cephalosporins, and carbapenem. The SIM family of beta-lactamases appear to be transferable through integrons. antibiotic_resistance ARO:3004206 SIM beta-lactamase SIM beta-lactamases are Class B beta-lactamases that are capable of hydrolyzing a wide variety of beta-lactams, including penicillins, narrow- to expanded-spectrum cephalosporins, and carbapenem. The SIM family of beta-lactamases appear to be transferable through integrons. PMID:16251286 PMID:20498315 KHM beta-lactamases are Class B beta-lactamases that can confer resistance to all classes of beta-lactams, except the monobactams. antibiotic_resistance ARO:3004207 KHM beta-lactamase DIM type beta-lactamases were first identified from a carbapenem-resistant Pseudomonas stutzeri strain isolated from a Dutch patient. Encoded in mobile elements, these MBLs significantly hydrolyze broad-spectrum cephalosporins and carbapenems. antibiotic_resistance ARO:3004208 DIM beta-lactamase DIM type beta-lactamases were first identified from a carbapenem-resistant Pseudomonas stutzeri strain isolated from a Dutch patient. Encoded in mobile elements, these MBLs significantly hydrolyze broad-spectrum cephalosporins and carbapenems. PMID:20308383 First identified from a multi-drug resistant Pseudomonas aeruginosa clinical isolate in 2012, HMB type beta-lactamases can be encoded in transposons and hydrolyze carbapenems. antibiotic_resistance ARO:3004209 HMB beta-lactamase First identified from a multi-drug resistant Pseudomonas aeruginosa clinical isolate in 2012, HMB type beta-lactamases can be encoded in transposons and hydrolyze carbapenems. PMID:28065891 This type of Subclass B2 beta-lactamases was first identified from a Serratia fonticola environmental isolate. antibiotic_resistance ARO:3004210 SFH beta-lactamase This type of Subclass B2 beta-lactamases was first identified from a Serratia fonticola environmental isolate. PMID:12821491 The FEZ family of beta-lactamases are subclass B3 beta-lactamases that hydrolyze penicillins, cephalosporins, and carbapenems. antibiotic_resistance ARO:3004211 FEZ beta-lactamase The FEZ family of beta-lactamases are subclass B3 beta-lactamases that hydrolyze penicillins, cephalosporins, and carbapenems. PMID:18563261 The GOB family of beta-lactamases have been discovered in the Elizabethkingia meningoseptica and are classified as subclass B3 beta-lactamase. They confer resistance to cephalosporins, penicillins, and carbapenems. antibiotic_resistance ARO:3004212 GOB beta-lactamase The GOB family of beta-lactamases have been discovered in the Elizabethkingia meningoseptica and are classified as subclass B3 beta-lactamase. They confer resistance to cephalosporins, penicillins, and carbapenems. PMID:10858348 PMID:17403673 PMID:27458232 GOB-18 is a member of subclass B3 GOB family of beta-lactamases isolated from Elizabethkingia meningoseptica. GOB-18 is unlike other subclass B3 beta-lactamases as it is fully active against a broad range of beta-lactam substrates using a single Zn(II) ion in its active site. GOB-18 antibiotic_resistance ARO:3004213 GOB-18 GOB-18 is a member of subclass B3 GOB family of beta-lactamases isolated from Elizabethkingia meningoseptica. GOB-18 is unlike other subclass B3 beta-lactamases as it is fully active against a broad range of beta-lactam substrates using a single Zn(II) ion in its active site. PMID:17403673 PMID:27458232 GOB-18 Beta-lactamases that are part of the THIN-B family, which is a subclass B3 beta-lactamase family and hydrolyze a broad spectrum of beta-lactams including penicillins, cephalosporins, and carbapenems. antibiotic_resistance ARO:3004214 THIN-B beta-lactamase Beta-lactamases that are part of the THIN-B family, which is a subclass B3 beta-lactamase family and hydrolyze a broad spectrum of beta-lactams including penicillins, cephalosporins, and carbapenems. PMID:11181369 PMID:15561856 This subclass B3 of beta-lactamses have the ability to hydrolyze cephalosporins. antibiotic_resistance ARO:3004215 L1 family beta-lactamase This subclass B3 of beta-lactamses have the ability to hydrolyze cephalosporins. PMID:9811546 A subclass B3 family of beta-lactamases that confer resistance to a range of beta-lactam antibiotics including penams, cephamycins, and cephalosporins. antibiotic_resistance ARO:3004216 AIM beta-lactamase A subclass B3 family of beta-lactamases that confer resistance to a range of beta-lactam antibiotics including penams, cephamycins, and cephalosporins. PMID:22664968 SMB beta-lactamases are a subclass B3 beta-lactamases that hydrolyze a variety of beta-lactams, including penicillins, cephalosporins, and carbapenems. antibiotic_resistance ARO:3004217 SMB beta-lactamase SMB beta-lactamases are a subclass B3 beta-lactamases that hydrolyze a variety of beta-lactams, including penicillins, cephalosporins, and carbapenems. PMID:22442240 CAU beta-lactamases are a subclass B3 family. antibiotic_resistance ARO:3004218 CAU beta-lactamase CAU beta-lactamases are a subclass B3 family. PMID:12019096 BJP beta-lactamases are a subclass B3 family. antibiotic_resistance ARO:3004219 BJP beta-lactamase BJP beta-lactamases are a subclass B3 family. PMID:16723554 PEDO family enzymes that are classified under subclass B3 (metallo-) beta-lactamases. antibiotic_resistance ARO:3004220 subclass B3 PEDO beta-lactamase CPS beta-lactamases are a subclass B3 family. antibiotic_resistance ARO:3004221 CPS beta-lactamase ESP family beta-lactamases are subclass B3 (metallo-) beta-lactamases. antibiotic_resistance ARO:3004222 ESP beta-lactamase ESP family beta-lactamases are subclass B3 (metallo-) beta-lactamases. PMID:26482314 MSI beta-lactamases are a family of subclass B3 (metallo-) beta-lactamases. antibiotic_resistance ARO:3004223 MSI beta-lactamase MSI beta-lactamases are a family of subclass B3 (metallo-) beta-lactamases. PMID:26482314 SPG beta-lactamases are a family of subclass B3 (metallo-) beta-lactamases. antibiotic_resistance ARO:3004224 SPG beta-lactamase SPG beta-lactamases are a family of subclass B3 (metallo-) beta-lactamases. PMID:26482314 A family encompassing subclass B3 Rm3-like beta-lactamases. antibiotic_resistance ARO:3004225 Rm3 family beta-lactamase A family encompassing subclass B3 Rm3-like beta-lactamases. PMID:27431213 Beta-lactamases that are part of the LRA gene family and are classified as B3 (metallo-) beta-lactamases. antibiotic_resistance ARO:3004226 subclass B3 LRA beta-lactamase Beta-lactamases that are part of the LRA gene family and are classified as B3 (metallo-) beta-lactamases. PMID:18843302 Beta-lactamases that are part of the PEDO gene family and are classified as subclass B1 (metallo-) beta-lactamases. antibiotic_resistance ARO:3004227 subclass B1 PEDO beta-lactamase Beta-lactamases that are part of the PEDO gene family and are classified as subclass B1 (metallo-) beta-lactamases. PMID:26482314 Beta-lactamases that are part of the LRA gene family and are classified as Class A beta-lactamases. antibiotic_resistance ARO:3004228 class A LRA beta-lactamase Beta-lactamases that are part of the LRA gene family and are classified as Class A beta-lactamases. PMID:18843302 Beta-lactamases belonging to the Bla genes from Bacillus anthracis that are classified as class A beta-lactamases. antibiotic_resistance ARO:3004229 class A Bacillus anthracis Bla beta-lactamase Beta-lactamases belonging to the Bla genes from Bacillus anthracis that are classified as class A beta-lactamases. PMID:12760895 Beta-lactamases belonging to the Bla genes from Bacillus anthracis that are classified as subclass B1 beta-lactamases. antibiotic_resistance ARO:3004230 subclass B1 Bacillus anthracis Bla beta-lactamase Beta-lactamases belonging to the Bla genes from Bacillus anthracis that are classified as subclass B1 beta-lactamases. PMID:12760895 Beta-lactamases that are part of the LRA gene family and are classified as Class C beta-lactamases. antibiotic_resistance ARO:3004231 class C LRA beta-lactamase Beta-lactamases that are part of the LRA gene family and are classified as Class C beta-lactamases. PMID:18843302 AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related. antibiotic_resistance ARO:3004232 ampC-type beta-lactamase AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related. PMID:21304033 Class A Beta-lactamases first isolated from Mycolicibacterium fortuitum. antibiotic_resistance ARO:3004233 blaF family beta-lactamase Class A Beta-lactamases first isolated from Mycolicibacterium fortuitum. PMID:8065266 Beta-lactamases part of this family discovered in Streptomyces albus G. antibiotic_resistance ARO:3004234 EXO beta-lactamase Beta-lactamases part of this family discovered in Streptomyces albus G. PMID:2658780 A family of class A beta-lactamases that have been discovered in the Rhodobacter genus. antibiotic_resistance ARO:3004235 RCP beta-lactamase A family of class A beta-lactamases that have been discovered in the Rhodobacter genus. PMID:2783689 PMID:2788410 This family of macrolide glycosyltransferases derive from gimA, which was discovered in Streptomyces ambofaciens. antibiotic_resistance ARO:3004236 gimA family macrolide glycosyltransferase This family of macrolide glycosyltransferases derive from gimA, which was discovered in Streptomyces ambofaciens. PMID:9756764 The mgt family encompasses macrolide glycotransferases of the Streptomyces genus. antibiotic_resistance ARO:3004237 mgt macrolide glycotransferase The mgt family encompasses macrolide glycotransferases of the Streptomyces genus. PMID:1605601 PMID:1612452 The sul genes encode forms of dihydropteroate synthase that confer resistance to sulfonamide. antibiotic_resistance ARO:3004238 sulfonamide resistant sul The sul genes encode forms of dihydropteroate synthase that confer resistance to sulfonamide. PMID:15673783 NPS-1 is a plasmid-encoded class D beta-lactamases identified from two Pseudomonas aeruginosa isolates in 1986. NPS-1 antibiotic_resistance ARO:3004239 NPS-1 NPS-1 is a plasmid-encoded class D beta-lactamases identified from two Pseudomonas aeruginosa isolates in 1986. PMID:11557499 PMID:3089139 NPS-1 NPS beta-lactamases are class D beta-lactamases that have partial hydrolyzing abilities against penicillins and cephalosporin. antibiotic_resistance ARO:3004240 NPS beta-lactamase Beta-lactamases that are part of the LRA gene family and are classified as Class D beta-lactamases. antibiotic_resistance ARO:3004241 class D LRA beta-lactamase Beta-lactamases that are part of the LRA gene family and are classified as Class D beta-lactamases. PMID:18843302 Members of the MSI-OXA family are class D beta-lactamases that encompass hybrids of MSI-1 and putative OXA homologues. antibiotic_resistance ARO:3004242 MSI-OXA family beta-lactamase Members of the MSI-OXA family are class D beta-lactamases that encompass hybrids of MSI-1 and putative OXA homologues. PMID:26482314 RbpA is a family of bacterial RNA polymerase-binding proteins, which acts as a transcription factor and binds to the sigma subunit of RNA polymerase. antibiotic_resistance ARO:3004243 RbpA bacterial RNA polymerase-binding protein RbpA is a family of bacterial RNA polymerase-binding proteins, which acts as a transcription factor and binds to the sigma subunit of RNA polymerase. PMID:16629670 PMID:22570422 The DnaA family of replication initiation proteins interact with RNA polymerase to confer resistance against rifampicin anitibiotics. antibiotic_resistance ARO:3004244 DnaA chromosomal replication initiation protein The DnaA family of replication initiation proteins interact with RNA polymerase to confer resistance against rifampicin anitibiotics. PMID:19170875 PMID:21527473 The fosC family of phosphotransferases phosphorylate fosfomycin to confer resistance and have been found in various bacterial isolates. antibiotic_resistance ARO:3004245 fosC phosphotransferase family The fosC family of phosphotransferases phosphorylate fosfomycin to confer resistance and have been found in various bacterial isolates. PMID:20404116 PMID:7492106 Two members of the Fom family have been identified, FomA and FomB. FomB must interact with FomA confer resistance to fosfomycin, however FomA is capable of conferring resistance alone. antibiotic_resistance ARO:3004246 Fom phosphotransferase family Fosfomycin is transported bacterial cells through transporters, one of them being glycerol-3-phosphate, which is encoded by the GlpT gene. Mutations in the GlpT gene can confer resistance to fosfomycin. antibiotic_resistance ARO:3004247 antibiotic-resistant GlpT UhpT encodes a transporter that can import fosfomycin-type drugs into bacterial cells. Mutations to UhpT confer resistance. antibiotic_resistance ARO:3004248 antibiotic-resistant UhpT UhpT encodes a transporter that can import fosfomycin-type drugs into bacterial cells. Mutations to UhpT confer resistance. PMID:28579984 UhpA acts as a positive regulator of UhpT, which is a transporter to bring fosfomycin drugs into bacterial cells. Mutations in UhpA that negatively impact the expression of UhpT can confer resistance. antibiotic_resistance ARO:3004249 UhpA UhpA acts as a positive regulator of UhpT, which is a transporter to bring fosfomycin drugs into bacterial cells. Mutations in UhpA that negatively impact the expression of UhpT can confer resistance. PMID:19671590 PMID:20071153 PtsI family phosphotransferases are involved in cyclic AMP synthesis, which regulates glpT expression. Mutations in PtsI family genes can negatively affect expression of UhpT, which is needed for fosfomycin import. antibiotic_resistance ARO:3004250 antibiotic-resistant ptsI phosphotransferase PtsI family phosphotransferases are involved in cyclic AMP synthesis, which regulates glpT expression. Mutations in PtsI family genes can negatively affect expression of UhpT, which is needed for fosfomycin import. PMID:20071153 Adenylate cyclases encoded by cya genes, which are involved in the synthesis cyclic AMP which regulates the fosfomycin transporter glpT. Mutations in cya genes can confer resistance to fosfomycin. antibiotic_resistance ARO:3004251 antibiotic-resistant cya adenylate cyclase Adenylate cyclases encoded by cya genes, which are involved in the synthesis cyclic AMP which regulates the fosfomycin transporter glpT. Mutations in cya genes can confer resistance to fosfomycin. PMID:14519998 Also known as vanUG, is a vanG variant found in the vanG gene cluster. vanU-G vanUG vanU_in_vanG_cl antibiotic_resistance ARO:3004253 vanU gene in vanG cluster Also known as vanUG, is a vanG variant found in the vanG gene cluster. PMID:11036060 PMID:14617152 PMID:16723588 vanU_in_vanG_cl Also known as vanVB, is a vanV variant found in the vanB gene cluster. It is found in some but not all vanB operons in E. faecalis, suggesting the existence of varied gene compositions in vanB operons. vanV-B vanVB vanV_in_vanB_cl antibiotic_resistance ARO:3004254 vanV gene in vanB cluster Also known as vanVB, is a vanV variant found in the vanB gene cluster. It is found in some but not all vanB operons in E. faecalis, suggesting the existence of varied gene compositions in vanB operons. PMID:21482081 vanV_in_vanB_cl vanJ and vanJ homologue proteins confer resistance to teicoplanin. antibiotic_resistance ARO:3004255 vanJ membrane protein vanJ and vanJ homologue proteins confer resistance to teicoplanin. PMID:22232274 Bleomycin resistant proteins (BRP) confer resistance to bleomycin and to bleomycin-like molecules. antibiotic_resistance ARO:3004256 Bleomycin resistant protein Bleomycin resistant proteins (BRP) confer resistance to bleomycin and to bleomycin-like molecules. PMID:18791008 PMID:22290943 Acetyltransferases of the cpa family confer resistance to capreomycin, an aminoglycoside antibiotic. antibiotic_resistance ARO:3004257 cpa acetyltransferase Acetyltransferases of the cpa family confer resistance to capreomycin, an aminoglycoside antibiotic. PMID:27929110 Bah amidohydrolases are membrane proteins that inactivate bacitracin. antibiotic_resistance ARO:3004260 Bah amidohydrolase Bah amidohydrolases are membrane proteins that inactivate bacitracin. PMID:27929110 Viomycin family of phosphotransferases confer resistance to viomycin antibiotics. antibiotic_resistance ARO:3004261 viomycin phosphotransferase Viomycin family of phosphotransferases confer resistance to viomycin antibiotics. PMID:2987648 Mutations to the liaF accessory protein that confer resistance to daptomycin. antibiotic_resistance ARO:3004262 daptomycin resistant liaF Mutations to the liaF accessory protein that confer resistance to daptomycin. PMID:21899450 Mutations to the liaR response regulator that confer resistance to daptomycin. antibiotic_resistance ARO:3004263 daptomycin resistant liaR Mutations in the liaS histidine kinase that confer daptomycin resistance. antibiotic_resistance ARO:3004264 daptomycin resistant liaS Mutations in the liaS histidine kinase that confer daptomycin resistance. PMID:21899450 Mutations to demA confer lycosin resistance. antibiotic_resistance ARO:3004265 lysocin resistant menA Mutations to demA confer lycosin resistance. PMID:25485686 Point mutations in katG confer antibiotic resistance by preventing katG from catalyzing the activation of antibiotics. antibiotic_resistance ARO:3004266 antibiotic resistant katG Point mutations in katG confer antibiotic resistance by preventing katG from catalyzing the activation of antibiotics. PMID:23744165 Point mutations in pncA prevent the enzyme from activating antibiotics, such as pyrazinamide. antibiotic_resistance ARO:3004267 antibiotic resistant pncA Point mutations in pncA prevent the enzyme from activating antibiotics, such as pyrazinamide. PMID:9055989 A group of mobile colistin resistance genes encode the MCR family of phosphoethanolamine transferases, which catalyze the addition of phosphoethanolamine onto lipid A, thus interfering with the binding of colistin to the cell membrane. antibiotic_resistance ARO:3004268 MCR phosphoethanolamine transferase A group of mobile colistin resistance genes encode the MCR family of phosphoethanolamine transferases, which catalyze the addition of phosphoethanolamine onto lipid A, thus interfering with the binding of colistin to the cell membrane. PMID:26603172 PMID:27401575 PMID:28487432 PMID:28655818 This family of phosphoethanolamine transferase catalyze the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine to lipid A, which impedes the binding of colistin to the cell membrane. antibiotic_resistance ARO:3004269 pmr phosphoethanolamine transferase This family of phosphoethanolamine transferase catalyze the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine to lipid A, which impedes the binding of colistin to the cell membrane. PMID:15205413 PMID:9570402 fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid. antibiotic_resistance ARO:3004270 antibiotic resistant fabI fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid. PMID:27577999 Methyltransferases that methylate the G1405 position of 16S rRNA, which is part of an aminoglycoside binding site. antibiotic_resistance ARO:3004271 16S rRNA methyltransferase (G1405) Methyltransferases that methylate the G1405 position of 16S rRNA, which is part of an aminoglycoside binding site. PMID:21177880 Methyltransferases that methylate the A1408 position of 16S rRNA, which is part of an aminoglycoside binding site. antibiotic_resistance ARO:3004272 16S rRNA methyltransferase (A1408) Methyltransferases that methylate the A1408 position of 16S rRNA, which is part of an aminoglycoside binding site. PMID:17875999 PMID:19589804 A family of lincosamide resistant 23S rRNA methyltransferases. The only member of the family discovered so far was isolated from Paenibacillus sp. LC231, a strain found in Lechuguilla Cave, NM, USA. antibiotic_resistance ARO:3004273 Llm 23S ribosomal RNA methyltransferase A family of lincosamide resistant 23S rRNA methyltransferases. The only member of the family discovered so far was isolated from Paenibacillus sp. LC231, a strain found in Lechuguilla Cave, NM, USA. PMID:27929110 Methyltransferases that modify the 23S rRNA of the 50S subunit of bacterial ribosomes, conferring resistance to drugs that target 23S rRNA. antibiotic_resistance ARO:3004274 23S ribosomal RNA methyltransferase Methyltransferases that modify the 23S rRNA of the 50S subunit of bacterial ribosomes, conferring resistance to drugs that target 23S rRNA. PMID:20144045 PMID:20618865 PMID:7590303 A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. antibiotic_resistance ARO:3004275 ANT(3'') A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. PMID:20833577 A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 2''-hydroxyl group of the compound. antibiotic_resistance ARO:3004276 ANT(2'') A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 2''-hydroxyl group of the compound. PMID:25564464 General bacterial porins are a family of porins found in the outer membrane of Gram-negative bacteria. They catalyze the energy-independent transport of small molecules across the outer membranes of bacteria. Most of the porins of these family are homotrimeric and have variable selectivity, ranging from being cation-selective, anion-selective or selective for different compounds. The most well characterized members of this family are the OmpF and OmpC porins of Escherichia coli. This family is also known as the classical porins. antibiotic_resistance ARO:3004277 General Bacterial Porin (GBP) General bacterial porins are a family of porins found in the outer membrane of Gram-negative bacteria. They catalyze the energy-independent transport of small molecules across the outer membranes of bacteria. Most of the porins of these family are homotrimeric and have variable selectivity, ranging from being cation-selective, anion-selective or selective for different compounds. The most well characterized members of this family are the OmpF and OmpC porins of Escherichia coli. This family is also known as the classical porins. PMID:18997824 The Opr family consists of porins in Pseudomonas species, and other Gram-negative bacteria, that exhibit a variety of substrate selectivities. antibiotic_resistance ARO:3004278 Outer Membrane Porin (Opr) The Opr family consists of porins in Pseudomonas species, and other Gram-negative bacteria, that exhibit a variety of substrate selectivities. PMID:18997824 Members of the Sugar Porin family tend to facilitate the transport of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. These porins form a homotrimeric structure. antibiotic_resistance ARO:3004279 Sugar Porin (SP) The MltA-interacting Protein (MipA) family consists mainly of homologs to MipA and OmpV proteins. Proteins of this family, are predicted to form a beta-barrel. antibiotic_resistance ARO:3004280 MipA-interacting Protein These are GBPs that are associated with decreased susceptibility to beta-lactams either through mutations in the porin protein, absence of the porin protein, or expression of the porin protein. antibiotic_resistance ARO:3004281 General Bacterial Porin with reduced permeability to beta-lactams These are GBPs that are associated with decreased susceptibility to peptide antibiotics either through mutations in the porin protein, absence of the porin protein, or expression of the porin protein. antibiotic_resistance ARO:3004282 General Bacterial Porin with reduced permeability to peptide antibiotics The imipenum resistance-associated CarO porin family is composed of the CarO porin originally identified in Acinetobacter baumannii. The loss of these porins is associated with imipenem and meropenem multi-drug resistance. The channels formed by CarO porins show slight cation selectivity. antibiotic_resistance ARO:3004283 CarO porin fabG is a 3-oxoacyl-acyl carrier protein reductase involved in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabG can confer resistance to Triclosan. antibiotic_resistance ARO:3004284 antibiotic resistant fabG A grouping of tunicamycin resistance proteins that are homologous to tmrB found in Bacillus subtilis. antibiotic_resistance ARO:3004285 tunicamycin resistance protein A grouping of tunicamycin resistance proteins that are homologous to tmrB found in Bacillus subtilis. PMID:1624425 Phenotypic variant regulator proteins play a role in controlling the switch between antibiotic-susceptible and antibiotic-resistant forms of bacteria. The characterized member of this family is the PvrR protein in Pseudomonas aeruginosa, which when absent, confers antibiotic resistance. antibiotic_resistance ARO:3004286 phenotypic variant regulator Phenotypic variant regulator proteins play a role in controlling the switch between antibiotic-susceptible and antibiotic-resistant forms of bacteria. The characterized member of this family is the PvrR protein in Pseudomonas aeruginosa, which when absent, confers antibiotic resistance. PMID:22195037 The antimicrobial activity of certain antibiotics, such as peptide antibiotics, is proposed to be initiated through binding to the lipid A moiety of lipopolysaccharides. Thus, covalent modification of Gram-negative bacterial lipid A by phosphatases is a mechanism to reduce the susceptibility of the bacteria to antibiotics. antibiotic_resistance ARO:3004287 lipid A phosphatase varG is an Ambler class B metallo-beta-lactamase found on the antibiotic resistance var regulon in Vibrio cholerae, along with an antibiotic efflux pump varABCDEF. These genes are organized as a regulon under the control of VarR transcriptional activator. VarG was shown to have beta-lactamase activity against penicillins, carbapenems and cephalosporins in-vitro. antibiotic_resistance ARO:3004288 Subclass B1 Vibrio cholerae varG beta-lactamase varG is an Ambler class B metallo-beta-lactamase found on the antibiotic resistance var regulon in Vibrio cholerae, along with an antibiotic efflux pump varABCDEF. These genes are organized as a regulon under the control of VarR transcriptional activator. VarG was shown to have beta-lactamase activity against penicillins, carbapenems and cephalosporins in-vitro. PMID:28898293 varG is an Ambler class B metallo-beta-lactamase found on the antibiotic resistance var regulon in Vibrio cholerae, along with an antibiotic efflux pump varABCDEF. These genes are organized as a regulon under the control of VarR transcriptional activator. VarG was shown to have beta-lactamase activity against penicillins, carbapenems and cephalosporins in-vitro. Described by Lin HV et al. 2017. Vcho_varG antibiotic_resistance ARO:3004289 Vibrio cholerae varG varG is an Ambler class B metallo-beta-lactamase found on the antibiotic resistance var regulon in Vibrio cholerae, along with an antibiotic efflux pump varABCDEF. These genes are organized as a regulon under the control of VarR transcriptional activator. VarG was shown to have beta-lactamase activity against penicillins, carbapenems and cephalosporins in-vitro. Described by Lin HV et al. 2017. PMID:28898293 Vcho_varG A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. Ecol_ampC_BLA antibiotic_resistance ARO:3004290 Escherichia coli ampC beta-lactamase A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. PMID:19136439 PMID:3055168 Ecol_ampC_BLA A periplasmic cephalosporinase described in Rhodobacter sphaeroides shown to contribute to resistance of beta-lactam antibiotics. Rsph_ampC_BLA antibiotic_resistance ARO:3004291 Rhodobacter sphaeroides ampC beta-lactamase A periplasmic cephalosporinase described in Rhodobacter sphaeroides shown to contribute to resistance of beta-lactam antibiotics. PMID:2783689 Rsph_ampC_BLA A chromosome-encoded class C beta-lactamase described in the pathogen Laribacter hongkongensis, often associated with gastroenteritis. Laribacter ampC has been shown to confer resistance to non-carbapenem beta-lactamases, as described by Lau et al. 2005. Lhon_ampC_BLA blaLHK-5 antibiotic_resistance ARO:3004292 Laribacter hongkongensis ampC beta-lactamase A chromosome-encoded class C beta-lactamase described in the pathogen Laribacter hongkongensis, often associated with gastroenteritis. Laribacter ampC has been shown to confer resistance to non-carbapenem beta-lactamases, as described by Lau et al. 2005. PMID:15855519 Lhon_ampC_BLA A class C beta-lactamase family of chromosome-encoded antibiotic resistance genes originally described from Buttiauxella spp. antibiotic_resistance ARO:3004293 BUT beta-lactamase A class C beta-lactamase family of chromosome-encoded antibiotic resistance genes originally described from Buttiauxella spp. PMID:12127496 A chromosome-encoded class C cephalosporinase and penicillinase from Buttiauxella spp. shown clinically to confer resistance to beta-lactam antibiotics. Described by Fihman et al. 2002. BUT-1 antibiotic_resistance ARO:3004294 BUT-1 A chromosome-encoded class C cephalosporinase and penicillinase from Buttiauxella spp. shown clinically to confer resistance to beta-lactam antibiotics. Described by Fihman et al. 2002. PMID:12127496 BUT-1 A ribosomally synthesized cyclic peptide antibiotic. Lassomycin has been shown to be effective against drug-resistant mycobacteria but shows little activity against other bacteria. Lassomycin targets and binds to a region of the ClpC1 ATPase complex and uncouples ATPase from proteolytic activity, an essential function for mycobacterial viability, causing cell death. pubchem.compound:132528125 antibiotic_resistance ARO:3004295 lassomycin A ribosomally synthesized cyclic peptide antibiotic. Lassomycin has been shown to be effective against drug-resistant mycobacteria but shows little activity against other bacteria. Lassomycin targets and binds to a region of the ClpC1 ATPase complex and uncouples ATPase from proteolytic activity, an essential function for mycobacterial viability, causing cell death. PMID:24684906 Bulgecin A is a lytic transglycosylase inhibitor and antibiotic potentiator produced from Pseudomonas mesoacidophila. In the presence of some beta-lactam antibiotics, including ampicillin and meropenem, bulgecin A has been shown to restore susceptibility to carbapenems in carbapenem-resistant pathogens. pubchem.compound:444940 antibiotic_resistance ARO:3004296 bulgecin A Bulgecin A is a lytic transglycosylase inhibitor and antibiotic potentiator produced from Pseudomonas mesoacidophila. In the presence of some beta-lactam antibiotics, including ampicillin and meropenem, bulgecin A has been shown to restore susceptibility to carbapenems in carbapenem-resistant pathogens. PMID:27703329 Qualitative description of a microbial response to antimicrobial agents and the expected clinical outcome. Bacteria may be susceptible or resistant to a broad range of antibiotic drugs or drug classes, with several intermediate states or phases. antibiotic_resistance ARO:3004299 antimicrobial phenotype Intermediate sensitivity of a bacterial strain to a given antibiotic occurs when it is inhibited by a concentration of the drug that is associated with uncertain therapeutic effect. The elimination of intermediate phenotype bacteria may depend on the site of infection and/or the concentration of the administered drug. Definition from https://clsi.org. antibiotic_resistance ARO:3004300 intermediate antimicrobial phenotype A bacterial strain is said to be resistant to a given antibiotic when it is inhibited in vitro by a concentration of this drug that is associated with a high likelihood of therapeutic failure. antibiotic_resistance ARO:3004301 resistant antimicrobial phenotype A bacterial strain is said to be resistant to a given antibiotic when it is inhibited in vitro by a concentration of this drug that is associated with a high likelihood of therapeutic failure. PMID:19626213 A bacterial strain is said to be susceptible to a given antibiotic when it is inhibited in vitro by a concentration of a drug that is associated with a high likelihood of therapeutic success. antibiotic_resistance ARO:3004302 susceptible antimicrobial phenotype A bacterial strain is said to be susceptible to a given antibiotic when it is inhibited in vitro by a concentration of a drug that is associated with a high likelihood of therapeutic success. PMID:19626213 A bacterial strain is said to be nonsusceptible to a given antibiotic drug if it demonstrates either an intermediate or resistant phenotype when exposed to a concentration of a drug that is associated with a high likelihood of therapeutic failure, i.e. if the bacterial strain is not susceptible to the antibiotic drug but not necessarily totally resistant under all conditions. Definition from https://clsi.org. nonsensitive antimicrobial phenotype antibiotic_resistance ARO:3004303 nonsusceptible antimicrobial phenotype A bacterial strain is said to be susceptible-dose dependent (SDD) to a given antibiotic when growth is inhibited with a high likelihood of therapeutic success, but when multiple approved dosing options exist. When a higher or more frequent dose is used, the predicted therapeutic result is the same as for susceptible individuals. SDD Sensitive dose dependent antimicrobial phenotype antibiotic_resistance ARO:3004304 susceptible dose dependent antimicrobial phenotype Multidrug-resistant organisms are defined as bacterial strains that have become resistant to multiple classes of antibacterial drugs or other agents. The phenotype of these organisms is defined by the spectrum of antibiotic drug classes to which that organism is resistant. Often, these organisms are susceptible to a narrow range of available drugs, making treatment difficult and urgent. MDRO antibiotic_resistance ARO:3004305 multidrug resistance antimicrobial phenotype Multidrug-resistant organisms are defined as bacterial strains that have become resistant to multiple classes of antibacterial drugs or other agents. The phenotype of these organisms is defined by the spectrum of antibiotic drug classes to which that organism is resistant. Often, these organisms are susceptible to a narrow range of available drugs, making treatment difficult and urgent. PMID:19626213 Any strain of Staphylococcus aureus that has tested resistant (R) to at least one of methicillin, oxacillin or cefoxitin by standard susceptibility testing methods. MRSA antibiotic_resistance ARO:3004306 methicillin-resistant Staphylococcus aureus Methicillin-resistant Staphylococcus aureus that has additionally tested resistant to the antibiotic drug linezolid. antibiotic_resistance ARO:3004307 Linezolid-resistant MRSA Methicillin-resistant Staphylococcus aureus that has additionally tested resistant to the fluoroquinolone antibiotics ciprofloxacin and/or levofloxacin. antibiotic_resistance ARO:3004308 Fluoroquinolone-resistant MRSA Methicillin-resistant Staphylococcus aureus that has additionally tested intermediate to vancomycin antibiotics. antibiotic_resistance ARO:3004309 Vancomycin-intermediate MRSA Methicillin-resistant Staphylococcus aureus that has additionally tested non-susceptible (NS, resistant or intermediate) to daptomycin antibiotics. antibiotic_resistance ARO:3004310 Daptomycin-resistant MRSA Any strain of Acinetobacter spp. that has tested either Intermediate or Resistant to at least one of the following carbapenem-class antibiotics by standard testing using approved breakpoints: imipenem, meropenem, doripenem. antibiotic_resistance ARO:3004311 carbapenem-resistant Acinetobacter Any strain of an Acinetobacter spp. that has either tested Intermediate or Resistant to at least one antibiotic drug in at least 3 of the 6 following categories: 1) Extended-spectrum cephalosporins, 2) Fluoroquinolone, 3) Aminoglycosides, 4) Carbapenems, 5) Piperacillin group, and 6) Ampicillin/sulbactam. antibiotic_resistance ARO:3004312 multidrug-resistant Acinetobacter Any strain of E. coli that has tested resistant to one of the following carbapenem antibiotics: imipenem, meropenem, doripenem, ertapenem. antibiotic_resistance ARO:3004313 carbapenem-resistant Escherichia coli Any E.coli that has tested resistant (R) to at least one of the following: ceftriaxone, ceftazidime, cefepime, and cefotaxime. antibiotic_resistance ARO:3004314 extended-spectrum cephalosporin-resistant Escherichia coli Any E.coli that has tested resistant (R) to at least one of the following: ciprofloxacin, levofloxacin, and moxifloxacin. antibiotic_resistance ARO:3004315 fluoroquinolone-resistant Escherichia coli Any E.coli that has tested either intermediate (I) or resistant (R) to at least one drug in at least 3 of the following 5 categories: 1) Extended-spectrum cephalosporins, 2) Fluoroquinolones (ciprofloxacin, levofloxacin, moxifloxacin), 3) Aminoglycosides (amikacin, gentamicin, tobramycin), 4) Carbapenems (imipenem, meropenem, doripenem, ertapenem), 5) Piperacillin Group (piperacillin, piperacillin/tazobactam). antibiotic_resistance ARO:3004316 multidrug-resistant Escherichia coli Any Enterobacter spp. that has tested resistant to at least one of the following antibiotic drugs: imipenem, meropenem, doripenem, ertapenem. antibiotic_resistance ARO:3004317 carbapenem-resistant Enterobacter Any Enterobacter spp. that has tested resistant to at least one of the following antibiotics: ceftriaxone, ceftazidime, cefepime, and/or cefotaxime. antibiotic_resistance ARO:3004318 extended-spectrum cephalosporin-resistant Enterobacter Any Enterobacter spp. that has tested either Intermediate or Resistant to at least one drug in at least 3 of the following categories: extended-spectrum cephalosporins, fluoroquinolones, aminoglycosides, carbapenems, and/or pipericillin/tazobactam. antibiotic_resistance ARO:3004319 multidrug-resistant Enterobacter Any Klebsiella oxytoca or Klebsiella pneumoniae that has tested resistant to at least one of the following antibiotics: imipenem, meropenem, doripenem, ertapenem. antibiotic_resistance ARO:3004320 carbapenem-resistant Klebsiella Any Klebsiella oxytoca or Klebsiella pneumoniae that has tested resistant to at least one of the following antibiotics: ceftriaxone, ceftazidime, cefepime, and/or cefotaxime. antibiotic_resistance ARO:3004321 extended-spectrum cephalosporin-resistant Klebsiella Any Klebsiella oxytoca or Klebsiella pneumoniae that has tested Intermediate or Resistant in at least 3 of the following categories: extended-spectrum cephalosporins, fluoroquinolones, aminoglycosides, carbapenems, or pipericillin/tazobactam. antibiotic_resistance ARO:3004322 multidrug-resistant Klebsiella Any strain of Pseudomonas aeruginosa that has tested either Intermediate or Resistant to at least one of the following antibiotics: imipenem, meropenem and/or doripenem. antibiotic_resistance ARO:3004323 carbapenem-resistant Pseudomonas aeruginosa Any strain of Pseudomonas aeruginosa that has tested Resistant to at least one of the following antibiotics: cefepime and/or ceftazidime. antibiotic_resistance ARO:3004324 extended-spectrum cephalosporin-resistant Pseudomonas aeruginosa MCR-4 is a plasmid-borne phosphoethanolamine transferase variant of MCR-1, isolated from Salmonella enterica serovar Typhimurium of porcine origin in Italy, Spain and Belgium through 2013 and 2015-2016. MCR-4 confers resistance to collistin via addition of a phosphoethanolamine group to lipid A, reducing the negative charge of the cell membrane. Described by Carattoli et al. 2017. MCR-4 MCR-4.1 antibiotic_resistance ARO:3004325 MCR-4.1 MCR-4 is a plasmid-borne phosphoethanolamine transferase variant of MCR-1, isolated from Salmonella enterica serovar Typhimurium of porcine origin in Italy, Spain and Belgium through 2013 and 2015-2016. MCR-4 confers resistance to collistin via addition of a phosphoethanolamine group to lipid A, reducing the negative charge of the cell membrane. Described by Carattoli et al. 2017. PMID:28797329 MCR-4.1 Any Pseudomonas aeruginosa that has tested resistant (R) to at least one of the following: ciprofloxacin, levofloxacin. antibiotic_resistance ARO:3004326 fluoroquinolone-resistant Pseudomonas aeruginosa Any Pseudomonas aeruginosa that has tested resistant (R) to at least one of the following: amikacin, gentamicin, tobramycin. antibiotic_resistance ARO:3004327 aminoglycoside-resistant Pseudomonas aeruginosa Any Pseudomonas aeruginosa that has tested resistant (R) to at least one of the following: piperacillin, piperacillin/tazobactam. antibiotic_resistance ARO:3004328 pipericillin-resistant Pseudomonas aeruginosa Any Enterococcus faecium or Enterococcus faecalis that has tested resistant (R) to vancomycin. VRE antibiotic_resistance ARO:3004329 vancomycin-resistant Enterococcus Any Enterococcus faecium or Enterococcus faecalis that has tested non-susceptible (NS) to daptomycin. antibiotic_resistance ARO:3004330 daptomycin-resistant Enterococcus Coagulase-Negative Staphylococci that has tested resistant(R) or intermediate(I) to vancomycin. antibiotic_resistance ARO:3004331 vancomycin-resistant coagulase-negative Staphylococci MCR-5 is a transposon-associated phosphoethanolamine transferase gene, identified in Salmonella Paratyphi B dTa+ (d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi B) isolates from food-producing animals. The isolates were collected between 2011 and 2013, and retrieved from the German National Reference Laboratory for Salmonella. MCR-5 confers resistance to collistin through the addition of a phosphoethanolamine group to lipid A, causing a reduction in negative charge of the cell membrane. Described by Borowiak et al, 2017. MCR-5.1 antibiotic_resistance ARO:3004332 MCR-5.1 MCR-5 is a transposon-associated phosphoethanolamine transferase gene, identified in Salmonella Paratyphi B dTa+ (d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi B) isolates from food-producing animals. The isolates were collected between 2011 and 2013, and retrieved from the German National Reference Laboratory for Salmonella. MCR-5 confers resistance to collistin through the addition of a phosphoethanolamine group to lipid A, causing a reduction in negative charge of the cell membrane. Described by Borowiak et al, 2017. PMID:28962028 PMID:30053115 MCR-5.1 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Point mutations in gyrA have been shown to decrease susceptibility to the antibiotic triclosan. Although the mechanism is unclear, it is hypothesized that changes in supercoiling activity of mutant DNA gyrase proteins alters expression of stress response pathways thereby indirectly decreasing triclosan susceptibility. It has been shown that triclosan does not interact directly with gyrA. antibiotic_resistance ARO:3004333 triclosan resistant gyrA DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Point mutations in gyrA have been shown to decrease susceptibility to the antibiotic triclosan. Although the mechanism is unclear, it is hypothesized that changes in supercoiling activity of mutant DNA gyrase proteins alters expression of stress response pathways thereby indirectly decreasing triclosan susceptibility. It has been shown that triclosan does not interact directly with gyrA. PMID:29091182 Point mutations in Salmonella enterica serovar Typhimurium which have been shown to increase the minimum inhibitory concentration of the antibiotic triclosan. It is hypothesized that decreased susceptibility to triclosan in Salmonella gyrA mutants occurs indirectly due to alterations in the stress response pathways. Sent_gyrA_TRC antibiotic_resistance ARO:3004334 Salmonella enterica gyrA with mutation conferring resistance to triclosan Point mutations in Salmonella enterica serovar Typhimurium which have been shown to increase the minimum inhibitory concentration of the antibiotic triclosan. It is hypothesized that decreased susceptibility to triclosan in Salmonella gyrA mutants occurs indirectly due to alterations in the stress response pathways. PMID:29091182 Sent_gyrA_TRC Point mutations in Escherichia coli which have been shown to increase the minimum inhibitory concentration of the antibiotic triclosan. It is hypothesized that decreased susceptibility to triclosan in E. coli gyrA mutants occurs indirectly due to alterations in the stress response pathways. Ecol_gyrA_TRC antibiotic_resistance ARO:3004335 Escherichia coli gyrA with mutation conferring resistance to triclosan Point mutations in Escherichia coli which have been shown to increase the minimum inhibitory concentration of the antibiotic triclosan. It is hypothesized that decreased susceptibility to triclosan in E. coli gyrA mutants occurs indirectly due to alterations in the stress response pathways. PMID:29091182 Ecol_gyrA_TRC An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-73 antibiotic_resistance ARO:3004336 PDC-73 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-73 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-74 antibiotic_resistance ARO:3004337 PDC-74 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-74 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-75 antibiotic_resistance ARO:3004338 PDC-75 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-75 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-76 antibiotic_resistance ARO:3004339 PDC-76 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-76 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-77 antibiotic_resistance ARO:3004340 PDC-77 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-77 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-78 antibiotic_resistance ARO:3004341 PDC-78 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-78 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-79 antibiotic_resistance ARO:3004342 PDC-79 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-79 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-80 antibiotic_resistance ARO:3004343 PDC-80 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-80 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-81 antibiotic_resistance ARO:3004344 PDC-81 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-81 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-82 antibiotic_resistance ARO:3004345 PDC-82 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-82 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-83 antibiotic_resistance ARO:3004346 PDC-83 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-83 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-84 antibiotic_resistance ARO:3004347 PDC-84 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-84 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-85 antibiotic_resistance ARO:3004348 PDC-85 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-85 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-86 antibiotic_resistance ARO:3004349 PDC-86 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-86 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-87 antibiotic_resistance ARO:3004350 PDC-87 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-87 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-88 antibiotic_resistance ARO:3004351 PDC-88 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-88 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-89 antibiotic_resistance ARO:3004352 PDC-89 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-89 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-90 antibiotic_resistance ARO:3004353 PDC-90 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-90 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-91 antibiotic_resistance ARO:3004354 PDC-91 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-91 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-92 antibiotic_resistance ARO:3004355 PDC-92 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-92 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-93 antibiotic_resistance ARO:3004356 PDC-93 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-93 A chloramphenicol acetyltransferase identified in Brevibacillus brevis and shown to confer resistance to chloramphenicol antibiotics. Described by Pawlowski et al. 2017. catV antibiotic_resistance ARO:3004357 catV A chloramphenicol acetyltransferase identified in Brevibacillus brevis and shown to confer resistance to chloramphenicol antibiotics. Described by Pawlowski et al. 2017. PMID:29259290 catV A family of class A beta-lactamase enzymes described in the gram-negative cocci Acidaminococcus fermentans. antibiotic_resistance ARO:3004358 ACI beta-lactamase A family of class A beta-lactamase enzymes described in the gram-negative cocci Acidaminococcus fermentans. PMID:11036038 A class A beta-lactamase described in Acidaminococcus fermentans. ACI-1 was the first description of a beta-lactamase enzyme in a gram-negative anaerobic cocci. Described by Galan et al 2000. ACI-1 antibiotic_resistance ARO:3004359 ACI-1 A class A beta-lactamase described in Acidaminococcus fermentans. ACI-1 was the first description of a beta-lactamase enzyme in a gram-negative anaerobic cocci. Described by Galan et al 2000. PMID:11036038 PMID:30014616 ACI-1 Uses breakpoints to create standards for interpreting the clinical outcome of an MIC value for a particular microbial species and antimicrobial agent. antibiotic_resistance ARO:3004360 antimicrobial resistance testing reference standard sul4 is a dihydropteroate synthase gene and mobile sulfonamide resistance gene shown to confer resistance when expressed in E. coli. sul4 antibiotic_resistance ARO:3004361 sul4 sul4 is a dihydropteroate synthase gene and mobile sulfonamide resistance gene shown to confer resistance when expressed in E. coli. PMID:29246178 sul4 A chromosome-carried OXA-48-like beta-lactamase, OXA-535, identified in Shewanella spp. JAB-1. Likely the progenitor to the plasmid-carried OXA-436. Expression of OXA-535 in E. coli demonstrated carbapenem-hydrolyzing activity. Described by Jousset et al. 2017. OXA-535 antibiotic_resistance ARO:3004362 OXA-535 OXA-535 Lipid A acyltransferase genes confer resistance to certain types of peptide antibiotics such as polymyxins through the aminoacylation of lipopolysaccharide, thereby decreasing the negative charge of the outer membrane surface. antibiotic_resistance ARO:3004363 lipid A acyltransferase Lipid A acyltransferase genes confer resistance to certain types of peptide antibiotics such as polymyxins through the aminoacylation of lipopolysaccharide, thereby decreasing the negative charge of the outer membrane surface. PMID:29101229 A member of the AlmEFG operon, responsible for polymyxin resistance in Vibrio cholerae. AlmG is a glycyltransferase closely related to lipid A acyltransferases. Described by Henderson JC et al. 2017. almG antibiotic_resistance ARO:3004364 almG A member of the AlmEFG operon, responsible for polymyxin resistance in Vibrio cholerae. AlmG is a glycyltransferase closely related to lipid A acyltransferases. Described by Henderson JC et al. 2017. PMID:29101229 almG BSAC is a British inter-professional organisation involved in antibiotic education, research and leadership. Baquero F. found that the BSAC system recommends lower breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG). antibiotic_resistance ARO:3004365 British Society for Antimicrobial Chemotherapy (BSAC) BSAC is a British inter-professional organisation involved in antibiotic education, research and leadership. Baquero F. found that the BSAC system recommends lower breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG). PMID:2226478 The Clinical and Laboratory Standards Institute develops and implements clinical laboratory testing standards. antibiotic_resistance ARO:3004366 Clinical and Laboratory Standards Institute (CLSI) DIN is recognized by the Federal Government of Germany as the competent standards organization for Germany and as the national standards body representing Germany in non-governmental international standards organizations. Baquero F. found that the DIN system recommends lower breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG). antibiotic_resistance ARO:3004367 Deutsches Institut für Normung (DIN) DIN is recognized by the Federal Government of Germany as the competent standards organization for Germany and as the national standards body representing Germany in non-governmental international standards organizations. Baquero F. found that the DIN system recommends lower breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG). PMID:2226478 EUCAST is a standing committee jointly organized by ESCMID, ECDC and European national breakpoint committees; it deals with breakpoints and technical aspects of phenotypic in-vitro antimicrobial susceptibility testing. antibiotic_resistance ARO:3004368 European Committee on Antimicrobial Susceptibility Testing (EUCAST) The French Society of Microbiology (SFM) is a non-profit association which aims to bring together microbiologists from French-speaking countries, working in the domains of bacteria, viruses, Fungi and parasites, and related medical, industrial and environmental microbiology, physiology, genetics, taxonomy, hygiene, and antimicrobial agents. Baquero F. found that the SFM system recommends higher breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG). antibiotic_resistance ARO:3004369 Société Française de Microbiologie (SFM) The French Society of Microbiology (SFM) is a non-profit association which aims to bring together microbiologists from French-speaking countries, working in the domains of bacteria, viruses, Fungi and parasites, and related medical, industrial and environmental microbiology, physiology, genetics, taxonomy, hygiene, and antimicrobial agents. Baquero F. found that the SFM system recommends higher breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG). PMID:2226478 Minimum inhibitory concentration (MIC), in microbiology, is the lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation. antibiotic_resistance ARO:3004370 minimum inhibitory concentration (MIC) Minimum inhibitory concentration (MIC), in microbiology, is the lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation. PMID:19626213 The measured or quantified MIC. antibiotic_resistance ARO:3004371 MIC value The measured or quantified MIC. PMID:19626213 Unit for measurement of minimum inhibitory concentration (MIC). antibiotic_resistance ARO:3004372 MIC unit Unit for measurement of minimum inhibitory concentration (MIC). PMID:19626213 A calcium-dependent cyclic lipopeptide found to be effective against multidrug-resistant Staphylococcus aureus in cutaneous wound infections. pubchem.compound:132274667 antibiotic_resistance ARO:3004374 malacidin A A calcium-dependent cyclic lipopeptide found to be effective against multidrug-resistant Staphylococcus aureus in cutaneous wound infections. PMID:29434326 Biosynthesis of malacidin A and malacidin B calcium-dependent cyclic lipopeptide antibiotics from uncultured soil bacteria. antibiotic_resistance ARO:3004375 malacidin biosynthesis Biosynthesis of malacidin A and malacidin B calcium-dependent cyclic lipopeptide antibiotics from uncultured soil bacteria. PMID:29434326 Biosynthesis of the broad-spectrum Rho transcription factor inhibitor bicyclomycin by hydroxylation of a tRNA-dependent cyclodipeptide synthase core. antibiotic_resistance ARO:3004376 bicyclomycin biosynthesis Biosynthesis of the broad-spectrum Rho transcription factor inhibitor bicyclomycin by hydroxylation of a tRNA-dependent cyclodipeptide synthase core. PMID:29053243 A plasmid-mediate quinolone efflux pump described in Klebsiella aerogenes and Escherichia coli. QepA3 confers resistance to fluoroquinolone antibiotics by expelling the antibiotic molecules from the cell. This is distinct from the usual chromosomal mutation mechanism of quinolone resistance. Described by Wang et al. 2017. QepA3 antibiotic_resistance ARO:3004378 QepA3 A plasmid-mediate quinolone efflux pump described in Klebsiella aerogenes and Escherichia coli. QepA3 confers resistance to fluoroquinolone antibiotics by expelling the antibiotic molecules from the cell. This is distinct from the usual chromosomal mutation mechanism of quinolone resistance. Described by Wang et al. 2017. PMID:26947590 QepA3 A plasmid-mediated quinolone efflux pump variant described in Escherichia coli. QepA4 confers resistance to quinolone and fluoroquinolone antibiotics by expulsion from the cell. Described by Manageiro et al. 2017. QepA4 antibiotic_resistance ARO:3004379 QepA4 A plasmid-mediated quinolone efflux pump variant described in Escherichia coli. QepA4 confers resistance to quinolone and fluoroquinolone antibiotics by expulsion from the cell. Described by Manageiro et al. 2017. PMID:29062302 QepA4 Antibiotic adjuvant and serine beta-lactamase inhibitor, often paired with meropenem for clinical use. pubchem.compound:56649692 antibiotic_resistance ARO:3004380 vaborbactam Antibiotic adjuvant and serine beta-lactamase inhibitor, often paired with meropenem for clinical use. PMID:29232103 An experimental test conducted inside of a living organism, none of which currently exist for antimicrobial resistance testing. antibiotic_resistance ARO:3004387 in-vivo microbial susceptibility test An experimental test conducted outside of a living organism, usually in a tube or plate. antibiotic_resistance ARO:3004388 in-vitro microbial susceptibility test Reagents and procedures used during microbial susceptibility testing. antibiotic_resistance ARO:3004389 reagent or protocol used for testing AMR System of analysis for determining antimicrobial susceptibility. antibiotic_resistance ARO:3004390 antimicrobial resistance test platform Microbial species are inoculated in a growth medium onto which antimicrobial agents are transferred by diffusion. antibiotic_resistance ARO:3004391 diffusion method Microbial species are inoculated in a growth medium onto which antimicrobial agents are transferred by diffusion. PMID:29403965 Components of complex mixtures such as plant extracts are separated across a TLC plate and tested for anti-microbial activity. antibiotic_resistance ARO:3004392 thin-layer chromatography (TLC)-bioautography Components of complex mixtures such as plant extracts are separated across a TLC plate and tested for anti-microbial activity. PMID:29403965 Allows for time-dependent or concentration-dependent analysis of antimicrobial effects. Several tubes of broth culture medium containing a suspension of the test microbe are treated with varying concentrations of the antimicrobial agent and the percentage of dead cells determined at various time points. time kill curve antibiotic_resistance ARO:3004393 time-kill test Allows for time-dependent or concentration-dependent analysis of antimicrobial effects. Several tubes of broth culture medium containing a suspension of the test microbe are treated with varying concentrations of the antimicrobial agent and the percentage of dead cells determined at various time points. PMID:29403965 Relies on the indirect measurement of microbe populations by quantifying microbial ATP production. antibiotic_resistance ARO:3004394 ATP bioluminescence assay Relies on the indirect measurement of microbe populations by quantifying microbial ATP production. PMID:29403965 Microbes exposed to antimicrobial agents are then stained with the intercalating agent propidium iodide. Damaged cells emit a positive signal that is detected by flow cytometry analysis. Flow cytometry can also be used to discriminate between dead, damaged and live cells. antibiotic_resistance ARO:3004395 flow cytofluorometric method Microbes exposed to antimicrobial agents are then stained with the intercalating agent propidium iodide. Damaged cells emit a positive signal that is detected by flow cytometry analysis. Flow cytometry can also be used to discriminate between dead, damaged and live cells. PMID:29403965 Test that directly detect the presence of a particular resistance mechanism. antibiotic_resistance ARO:3004396 mechanism-specific test The microbial species are inoculated in liquid growth medium containing incremental dilutions (usually 2-fold) of the antimicrobial agent. antibiotic_resistance ARO:3004397 broth dilution method The microbial species are inoculated in liquid growth medium containing incremental dilutions (usually 2-fold) of the antimicrobial agent. PMID:29403965 Automated system of analysis for determining antimicrobial susceptibility. antibiotic_resistance ARO:3004398 automated testing platform Non-automated system of analysis for determining antimicrobial susceptibility. noncommercial testing platform antibiotic_resistance ARO:3004399 manual testing platform Specific automated system of analysis for determining antimicrobial susceptibility developed by Omron. antibiotic_resistance ARO:3004400 MicroScan Specific automated system of analysis for determining antimicrobial susceptibility developed by Becton Dickinson. antibiotic_resistance ARO:3004401 Phoenix Specific automated system of analysis for determining antimicrobial susceptibility developed by Trek, Thermo Fisher Scientific. antibiotic_resistance ARO:3004402 Sensitire Specific automated system of analysis for determining antimicrobial susceptibility developed by bioMérieux. antibiotic_resistance ARO:3004403 Vitek System Vendor of automated system of analysis for determining antimicrobial susceptibility. antibiotic_resistance ARO:3004404 automated testing platform vendor Specific vendor of automated system of analysis for determining antimicrobial susceptibility headquartered in New Jersey, USA. Becton Dickinson is the developer of the Phoenix automated testing platform. antibiotic_resistance ARO:3004405 Becton Dickinson Specific vendor of automated system of analysis for determining antimicrobial susceptibility headquartered in France. bioMérieux is the developer of the Vitek automated testing platform. antibiotic_resistance ARO:3004406 bioMérieux Specific vendor of automated system of analysis for determining antimicrobial susceptibility headquartered in Berlin and Munich. antibiotic_resistance ARO:3004407 Siemens Specific vendor of automated system of analysis for determining antimicrobial susceptibility based in Japan. Omron is the developer of the MicroScan automated testing platform. antibiotic_resistance ARO:3004408 Omron Specific vendor of automated system of analysis for determining antimicrobial susceptibility that was acquired by Thermo Fisher Scientific Inc. Thermo Fisher Scienfiic Inc. is headquartered in Massachusetts, USA. Trek is the developer of the Sensitire automated testing platform. Thermo Fisher Scientific antibiotic_resistance ARO:3004409 Trek Broth dilution conducted on 96-well microtiter plates (≤200 µL per well). antibiotic_resistance ARO:3004410 micro broth dilution method Broth dilution conducted on 96-well microtiter plates (≤200 µL per well). PMID:29403965 This test is a common method of evaluating the antimicrobial activity of plants or microbial extracts. In this method, bacteria are inoculated onto agar plates and the antimicrobial agent is injected into the plate and allowed to diffuse. antibiotic_resistance ARO:3004411 agar well diffusion method This test is a common method of evaluating the antimicrobial activity of plants or microbial extracts. In this method, bacteria are inoculated onto agar plates and the antimicrobial agent is injected into the plate and allowed to diffuse. PMID:29403965 This method is commonly used to study the antagonism between microorganisms. The first bacterial strain is inoculated onto agar plates in tight streaks. The bacteria will secrete molecules that diffuse in the agar medium; this medium is cut and placed on another agar plate inoculated with another microorganism. antibiotic_resistance ARO:3004412 agar plug diffusion method This method is commonly used to study the antagonism between microorganisms. The first bacterial strain is inoculated onto agar plates in tight streaks. The bacteria will secrete molecules that diffuse in the agar medium; this medium is cut and placed on another agar plate inoculated with another microorganism. PMID:29403965 This method is commonly used to study the antagonism between microorganisms. The microbial strain of interest is seeded by a single streak in the center of the agar plate. After incubation, the plate is seeded with the second microorganism by single streak perpendicular to the central streak. antibiotic_resistance ARO:3004413 cross streak method This method is commonly used to study the antagonism between microorganisms. The microbial strain of interest is seeded by a single streak in the center of the agar plate. After incubation, the plate is seeded with the second microorganism by single streak perpendicular to the central streak. PMID:29403965 The antimicrobial agent is transferred from a chromatogram to an agar plate previously inoculated with the test microorganism. antibiotic_resistance ARO:3004414 agar diffusion bioautography The antimicrobial agent is transferred from a chromatogram to an agar plate previously inoculated with the test microorganism. PMID:29403965 A developed TLC plate is dipped into or sprayed with a microbial suspension and then incubated. Live microbial cells are visualized using tetrazolium salts. antibiotic_resistance ARO:3004415 direct bioautography A developed TLC plate is dipped into or sprayed with a microbial suspension and then incubated. Live microbial cells are visualized using tetrazolium salts. PMID:29403965 The TLC plate is covered with a molten agar medium seeded with the test microbe and the antimicrobial compounds are allowed to diffuse onto the agar medium. Tetrazolium dye staining allows for visualization. agar overlay bioassay antibiotic_resistance ARO:3004416 agar overlay bioautography The TLC plate is covered with a molten agar medium seeded with the test microbe and the antimicrobial compounds are allowed to diffuse onto the agar medium. Tetrazolium dye staining allows for visualization. PMID:29403965 Concentration at which bacterial cells in suspension, calculated with respect to final volume (colony forming units/milliliter (cfu/mL)). The standard for broth dilution is 5 x 105cfu/mL. The standard for agar dilution is 104cfu/mL. antibiotic_resistance ARO:3004417 inoculum Concentration at which bacterial cells in suspension, calculated with respect to final volume (colony forming units/milliliter (cfu/mL)). The standard for broth dilution is 5 x 105cfu/mL. The standard for agar dilution is 104cfu/mL. PMID:18274517 Medium that supports microorganism growth. antibiotic_resistance ARO:3004418 growth medium Assay for beta lactamase detection. antibiotic_resistance ARO:3004419 chromogenic cephalosporinase test Assay for beta lactamase detection. PMID:34624 Commercial colorimetric assay for detection of chloramphenicol modifying enzyme chloramphenicol acetyltransferase. antibiotic_resistance ARO:3004420 chloramphenicol acetyltransferase assay (CAT) Commercial colorimetric assay for detection of chloramphenicol modifying enzyme chloramphenicol acetyltransferase. PMID:20439409 Greater than 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution. antibiotic_resistance ARO:3004421 greater than standard inoculum Greater than 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution. PMID:18274517 Less than 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution. antibiotic_resistance ARO:3004422 less than standard inoculum Less than 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution. PMID:18274517 Around equal to 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution. antibiotic_resistance ARO:3004423 = standard inoculum Around equal to 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution. PMID:18274517 General purpose medium used for culture of nonfastidious microorganisms. antibiotic_resistance ARO:3004424 Mueller-Hinton Broth Incubation atmosphere supplemented with CO2. antibiotic_resistance ARO:3004425 CO2 supplemented medium Medium supplementation with 20–25 mg Ca2+ and 10–12.5 mg Mg2+ per liter, which is representative of the divalent cation concentration in blood. Divalent cation supplemented medium is correct to use for susceptibility testing of tetracyclines, daptomycin for gram-positive bacteria and aminoglycosides for Pseudomonas aeruginosarequires. antibiotic_resistance ARO:3004426 divalent cation supplemented medium Medium supplementation with 20–25 mg Ca2+ and 10–12.5 mg Mg2+ per liter, which is representative of the divalent cation concentration in blood. Divalent cation supplemented medium is correct to use for susceptibility testing of tetracyclines, daptomycin for gram-positive bacteria and aminoglycosides for Pseudomonas aeruginosarequires. PMID:1551973 Growth medium supplemented with 2% (wt/vol) sodium chloride for testing susceptibility of Staphylococcus aureus to methicillin, oxacillin and nafcillin. antibiotic_resistance ARO:3004427 NaCl supplemented medium Growth medium supplemented with 2% (wt/vol) sodium chloride for testing susceptibility of Staphylococcus aureus to methicillin, oxacillin and nafcillin. PMID:12691545 Low thymine and thymidine content. antibiotic_resistance ARO:3004428 Difco Mueller-Hinton Broth High thymine and thymidine content. antibiotic_resistance ARO:3004429 BBL Mueller-Hinton Broth The tissue type used to select breakpoints from a particular standard, for the interpretation of MIC results. antibiotic_resistance ARO:3004430 antimicrobial resistance tissue specificity Qualitative description of a microbial response to antimicrobial agents as described by EUCAST using breakpoints determined through in-vitro testing. These breakpoints are determined irrespective of tissue specificity of infection. antibiotic_resistance ARO:3004431 EUCAST antimicrobial phenotype A microbe whose susceptibility to antibiotics is comparable to that of a reference susceptible microbe, meaning that the microbe is sensitive to the particular antibiotic. antibiotic_resistance ARO:3004432 wild-type A microbe whose susceptibility to antibiotics differs from that of a reference susceptible microbe, meaning that the microbe is resistant to the particular antibiotic. antibiotic_resistance ARO:3004433 non wild-type Vendor of AMR testing equipment and reagents. antibiotic_resistance ARO:3004438 AMR testing vendor Details required in reporting antimicrobial resistance. antibiotic_resistance ARO:3004439 component of AMR phenotype measurement Qualitative description of a microbial response to antimicrobial agents as described by CLSI using breakpoints that take into consideration tissue specificity of infection. antibiotic_resistance ARO:3004440 CLSI antimicrobial phenotype Tet(59) is a chromosome-encoded tetracycline efflux pump described from a Chinese pig manure sample. tet(59) tet59 antibiotic_resistance ARO:3004441 tet(59) Tet(59) is a chromosome-encoded tetracycline efflux pump described from a Chinese pig manure sample. PMID:27565618 tet(59) tet(W/N/W) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(W/N/W) tetWNW antibiotic_resistance ARO:3004442 tet(W/N/W) tet(W/N/W) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:27565618 tet(W/N/W) A family of class A beta-lactamase enzymes, RSA beta-lactamases show carbapenemase and cephalosporinase activity. antibiotic_resistance ARO:3004443 RSA beta-lactamase A family of class A beta-lactamase enzymes, RSA beta-lactamases show carbapenemase and cephalosporinase activity. PMID:29316517 RSA1-1 is a class A beta-lactamase resistance enzyme identified from a functional metagenomic study of contaminated river sediments. RSA1-1 antibiotic_resistance ARO:3004444 RSA1-1 RSA1-1 is a class A beta-lactamase resistance enzyme identified from a functional metagenomic study of contaminated river sediments. PMID:29316517 RSA1-1 PBP3 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the ftsI gene in Haemophilus influenzae. Mutations in ftsI confer resistance to beta-lactam antibiotics. Hinf_PBP3_BLA antibiotic_resistance ARO:3004446 Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics PBP3 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the ftsI gene in Haemophilus influenzae. Mutations in ftsI confer resistance to beta-lactam antibiotics. PMID:29352811 Hinf_PBP3_BLA A class A beta-lactamase family shown to hydrolyze penicillin but without cephalosporinase activity. antibiotic_resistance ARO:3004447 HERA beta-lactamase A class A beta-lactamase family shown to hydrolyze penicillin but without cephalosporinase activity. PMID:12878539 A class A beta-lactamase with penicillinase activity described in Atlantibacter (Escherichia) hermannii. HER-1 HERA-1 antibiotic_resistance ARO:3004448 HERA-1 A class A beta-lactamase with penicillinase activity described in Atlantibacter (Escherichia) hermannii. PMID:12878539 HERA-1 A class C beta-lactamase endogenous to Aeromonas enteropelogenes (tructi). antibiotic_resistance ARO:3004449 TRU beta-lactamase A class C beta-lactamase endogenous to Aeromonas enteropelogenes (tructi). PMID:20124004 A class C beta-lactamase enzyme identified from Aeromonas enteropelogenes. TRU-1 confers resistance to penicillin and cephalosporin antibiotics. TRU-1 antibiotic_resistance ARO:3004450 TRU-1 A class C beta-lactamase enzyme identified from Aeromonas enteropelogenes. TRU-1 confers resistance to penicillin and cephalosporin antibiotics. PMID:20124004 TRU-1 A chloramphenicol resistance determinant described in the Gram-negative bacterium Agrobacterium fabrum. Afab_ACT_CHL antibiotic_resistance ARO:3004451 Agrobacterium fabrum chloramphenicol acetyltransferase A chloramphenicol resistance determinant described in the Gram-negative bacterium Agrobacterium fabrum. PMID:2013403 Afab_ACT_CHL A chloramphenicol resistance determinant described in Alkalihalobacillus clausii. Acla_ACT_CHL antibiotic_resistance ARO:3004452 Alkalihalobacillus clausii chloramphenicol acetyltransferase A chloramphenicol resistance determinant described in Alkalihalobacillus clausii. PMID:19459958 Acla_ACT_CHL A chloramphenicol resistance determinant described in Campylobacter coli. Ccol_ACT_CHL antibiotic_resistance ARO:3004454 Campylobacter coli chloramphenicol acetyltransferase A chloramphenicol resistance determinant described in Campylobacter coli. PMID:2227449 Ccol_ACT_CHL A chloramphenicol resistance determinant described in Streptococcus suis. Ssui_ACT_CHL antibiotic_resistance ARO:3004455 Streptococcus suis chloramphenicol acetyltransferase A chloramphenicol resistance determinant described in Streptococcus suis. PMID:12726767 Ssui_ACT_CHL A chloramphenicol resistance determinant described in an Enterococcus faecium plasmid. Efac_ACT_CHL antibiotic_resistance ARO:3004456 Enterococcus faecium chloramphenicol acetyltransferase A chloramphenicol resistance determinant described in an Enterococcus faecium plasmid. PMID:12603745 Efac_ACT_CHL A chloramphenicol resistance determinant described in Staphylococcus intermedius. Sint_ACT_CHL antibiotic_resistance ARO:3004457 Staphylococcus intermedius chloramphenicol acetyltransferase A chloramphenicol resistance determinant described in Staphylococcus intermedius. PMID:1713259 Sint_ACT_CHL A chloramphenicol acetyltransferase and resistance determinant described in Enterococcus faecalis. Efae_ACT_CHL antibiotic_resistance ARO:3004458 Enterococcus faecalis chloramphenicol acetyltransferase A chloramphenicol acetyltransferase and resistance determinant described in Enterococcus faecalis. PMID:11735367 Efae_ACT_CHL A chloramphenicol resistance determinant described in a Vibrio anguillarum plasmid sequence. Vang_ACT_CHL antibiotic_resistance ARO:3004460 Vibrio anguillarum chloramphenicol acetyltransferase A chloramphenicol resistance determinant described in a Vibrio anguillarum plasmid sequence. PMID:1406372 Vang_ACT_CHL Delafloxacin is a novel fluoroquinolone antibiotic, differentiated from other on-market fluoroquinolones by the absence of a protonatable substituent conferring a weakly acidic character to the molecule. This property results in increased intracellular penetration and enhanced bactericidal activity under acidic conditions. pubchem.compound:487101 antibiotic_resistance ARO:3004462 delafloxacin Delafloxacin is a novel fluoroquinolone antibiotic, differentiated from other on-market fluoroquinolones by the absence of a protonatable substituent conferring a weakly acidic character to the molecule. This property results in increased intracellular penetration and enhanced bactericidal activity under acidic conditions. PMID:29605887 EBR-2 is a novel EBR-like class B beta-lactamase isolated from an extensively drug-resistant strain of Empedobacter falsenii. EBR-2 antibiotic_resistance ARO:3004463 EBR-2 EBR-2 is a novel EBR-like class B beta-lactamase isolated from an extensively drug-resistant strain of Empedobacter falsenii. PMID:29687150 EBR-2 CFE-2 is a plasmid-encoded AmpC beta-lactamase first described from Citrobacter freundii by Chen et al. 2018. CFE-2 antibiotic_resistance ARO:3004464 CFE-2 CFE-2 is a plasmid-encoded AmpC beta-lactamase first described from Citrobacter freundii by Chen et al. 2018. PMID:29944954 CFE-2 Chromosomally-encoded phosphoethanolamine (PEtN) transferases shown to confer resistance to polymyxin antibiotics, including colistin. antibiotic_resistance ARO:3004465 intrinsic colistin resistant phosphoethanolamine transferase A chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella catarrhalis. ICR-Mc is the protein that represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases. ICR-Mc antibiotic_resistance ARO:3004466 ICR-Mc A chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella catarrhalis. ICR-Mc is the protein that represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases. PMID:29631403 ICR-Mc A class of phosphotransferase enzymes shown to confer resistance to ciprofloxacin by antibiotic inactivation through phosphorylation. The sole example, CrpP, was thought to confer resistance to ciprofloxacin by antibiotic inactivation through phosphorylation, however in the paper by Zubyk & Wright (2021) this was discovered to not be the case. There are no known experimentally validated examples of enzymes with this function. CrpP antibiotic_resistance ARO:3004467 ciprofloxacin phosphotransferase A class of phosphotransferase enzymes shown to confer resistance to ciprofloxacin by antibiotic inactivation through phosphorylation. The sole example, CrpP, was thought to confer resistance to ciprofloxacin by antibiotic inactivation through phosphorylation, however in the paper by Zubyk & Wright (2021) this was discovered to not be the case. There are no known experimentally validated examples of enzymes with this function. PMID:29581123 PMID:34001507 A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins. antibiotic_resistance ARO:3004469 ABC-F ATP-binding cassette ribosomal protection protein A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins. PMID:27006457 PMID:29376318 PoxtA is an ABC-F subfamily ATP-binding cassette protein that confers resistance to tetracycline, -phenicol, and oxazolidinone via modification of the bacterial ribosome. The encoding gene was isolated from a methicillin-resistant Staphylococcus aureus strain. poxtA antibiotic_resistance ARO:3004470 poxtA PoxtA is an ABC-F subfamily ATP-binding cassette protein that confers resistance to tetracycline, -phenicol, and oxazolidinone via modification of the bacterial ribosome. The encoding gene was isolated from a methicillin-resistant Staphylococcus aureus strain. PMID:29635422 poxtA msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. antibiotic_resistance ARO:3004471 msr-type ABC-F protein A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome. antibiotic_resistance ARO:3004472 lsa-type ABC-F protein A carbapenem antibiotic, administered as the oral drug tebipenem-pivoxil, shown to be effective at treating bacterial infections. pubchem.compound:9800194 antibiotic_resistance ARO:3004473 tebipenem A carbapenem antibiotic, administered as the oral drug tebipenem-pivoxil, shown to be effective at treating bacterial infections. PMID:30014729 A siderophore cephalosporin with antibiotic activity against Gram-negative pathogens including and specifically Pseudomonas aeruginosa. pubchem.compound:77843966 antibiotic_resistance ARO:3004474 cefiderocol A siderophore cephalosporin with antibiotic activity against Gram-negative pathogens including and specifically Pseudomonas aeruginosa. PMID:29960205 vmlR is an ABC-F ATPase ribosomal protection protein identified in Bacillus subtilus. Shown to confer resistance to lincomycin and streptogramin A virginiamycin. Described by Crowe-McAuliffe et al. 2018. vmlR antibiotic_resistance ARO:3004476 vmlR vmlR is an ABC-F ATPase ribosomal protection protein identified in Bacillus subtilus. Shown to confer resistance to lincomycin and streptogramin A virginiamycin. Described by Crowe-McAuliffe et al. 2018. PMID:30126986 PMID:36951104 vmlR Eremomycin pyrrolidide 3, 4, 5, and 6 are semisynthetic glycopeptide derived from vancomycin or eremomycin. There have high activity against staphylococci and enterococci, including vancomycin-resistant strains. antibiotic_resistance ARO:3004477 eremomycin pyrrolidide Eremomycin pyrrolidide 3, 4, 5, and 6 are semisynthetic glycopeptide derived from vancomycin or eremomycin. There have high activity against staphylococci and enterococci, including vancomycin-resistant strains. PMID:30237697 Beta-lactamase found in Acinetobacter rudis efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins. OXA-665 antibiotic_resistance ARO:3004478 OXA-665 Beta-lactamase found in Acinetobacter rudis efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins. PMID:30247543 OXA-665 Beta-lactamase found in Acinetobacter spp. efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins. OXA-664 antibiotic_resistance ARO:3004479 OXA-664 Beta-lactamase found in Acinetobacter spp. efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins. PMID:30247543 OXA-664 Bifidobacterium are antibiotic resistant probiotics are prescribed to upkeep the population beneficial bacteria in the gut microbiome. However, horizontal gene transfer among gut microbes could create harmful antibiotic-resistant pathogenic bacteria, such as Mycobacterium tuberculosis. Lokesh et al. analyzed Bifidobacterium antitubercular drug resistance and mutations in rpoB. They found that B. animalis, B. longum and B. adolescentis showed considerable resistance to pyrazinamide, isoniazid, and streptomycin, while B. adolescentis had mutations both in the rifampicin (RIF) pocket and in regions outside the pockets, and also showed considerable resistance to RIF. Bado_rpoB_RIF antibiotic_resistance ARO:3004480 Bifidobacterium adolescentis rpoB mutants conferring resistance to rifampicin Bifidobacterium are antibiotic resistant probiotics are prescribed to upkeep the population beneficial bacteria in the gut microbiome. However, horizontal gene transfer among gut microbes could create harmful antibiotic-resistant pathogenic bacteria, such as Mycobacterium tuberculosis. Lokesh et al. analyzed Bifidobacterium antitubercular drug resistance and mutations in rpoB. They found that B. animalis, B. longum and B. adolescentis showed considerable resistance to pyrazinamide, isoniazid, and streptomycin, while B. adolescentis had mutations both in the rifampicin (RIF) pocket and in regions outside the pockets, and also showed considerable resistance to RIF. PMID:30093677 Bado_rpoB_RIF An OXA-10 family class beta-lactamase identified from a Klebsiella pneumoniae BIDMC 35 isolate. OXA-663 antibiotic_resistance ARO:3004489 OXA-663 An OXA-10 family class beta-lactamase identified from a Klebsiella pneumoniae BIDMC 35 isolate. PMID:30126962 OXA-663 A novel nitroimidazole antibiotic for treating Mycobacterium tuberculosis infection. Delamanid inhibits bacterial cell wall growth by mycolic acid synthesis disruption and is particularly effective in combination therapies against multidrug-resistant tuberculosis. pubchem.compound:6480466 deltyba antibiotic_resistance ARO:3004490 delamanid A novel nitroimidazole antibiotic for treating Mycobacterium tuberculosis infection. Delamanid inhibits bacterial cell wall growth by mycolic acid synthesis disruption and is particularly effective in combination therapies against multidrug-resistant tuberculosis. PMID:25210407 A class of antibiotics used to treat specifically Mycobacterium tuberculosis infection; therefore, referred to as an antimycobacterial. Diarylquinoline antibiotics inhibit ATP synthesis in tuberculosis cells by disruption of mycobacterial ATP synthase. antibiotic_resistance ARO:3004491 diarylquinoline antibiotic A class of antibiotics used to treat specifically Mycobacterium tuberculosis infection; therefore, referred to as an antimycobacterial. Diarylquinoline antibiotics inhibit ATP synthesis in tuberculosis cells by disruption of mycobacterial ATP synthase. PMID:24130398 A diarylquinoline antibiotic drug sold under the brand name Sirturo, used to treat infection from Mycobacterium spp., particularly multidrug-resistant tuberculosis. Bedaquiline disrupts ATP synthase by proton pump blockage, inhibiting ATP synthesis. pubchem.compound:5388906 Sirturo antibiotic_resistance ARO:3004492 bedaquiline A diarylquinoline antibiotic drug sold under the brand name Sirturo, used to treat infection from Mycobacterium spp., particularly multidrug-resistant tuberculosis. Bedaquiline disrupts ATP synthase by proton pump blockage, inhibiting ATP synthesis. PMID:24130398 A class C carbapenemase and extended-spectrum beta-lactamase identified from Acinetobacter baumannii. ADC-68 antibiotic_resistance ARO:3004493 ADC-68 A class C carbapenemase and extended-spectrum beta-lactamase identified from Acinetobacter baumannii. PMID:25372683 ADC-68 An IMP class B metallo-beta-lactamase enzyme identified from Acinetobacter baumannii. IMP-55 antibiotic_resistance ARO:3004494 IMP-55 An IMP class B metallo-beta-lactamase enzyme identified from Acinetobacter baumannii. PMID:28336429 IMP-55 An IMP class B metallo-beta-lactamase enzyme identified from carbapenem-resistant Pseudomonas aeruginosa. IMP-56 antibiotic_resistance ARO:3004495 IMP-56 IMP-56 A KPC class A beta-lactamase and carbapenemase identified from Chilean isolates of Klebsiella pneumoniae. KPC-24 antibiotic_resistance ARO:3004496 KPC-24 A KPC class A beta-lactamase and carbapenemase identified from Chilean isolates of Klebsiella pneumoniae. PMID:27436389 KPC-24 A trimethoprim-resistant dihydrofolate reductase characterized on a class I integron from an E. coli isolate. dfrA2d dfrB4 antibiotic_resistance ARO:3004498 dfrB4 A trimethoprim-resistant dihydrofolate reductase characterized on a class I integron from an E. coli isolate. PMID:28242670 dfrB4 Tosufloxacin is a fluoroquinolone antibiotic with an extended spectrum of activity. pubchem.compound:5517 antibiotic_resistance ARO:3004499 Tosufloxacin Tosufloxacin is a fluoroquinolone antibiotic with an extended spectrum of activity. PMID:1906696 An MCR-3 phosphoethanolamine transferase and polymyxin resistance gene variant differing by 2 amino acid substitutions, identified from an Escherichia coli isolate. MCR-3.11 antibiotic_resistance ARO:3004500 MCR-3.11 An MCR-3 phosphoethanolamine transferase and polymyxin resistance gene variant differing by 2 amino acid substitutions, identified from an Escherichia coli isolate. PMID:29760138 MCR-3.11 An MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in the United Kingdom. MCR-6.1 antibiotic_resistance ARO:3004501 MCR-6.1 An MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in the United Kingdom. PMID:30053008 MCR-6.1 An MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in Great Britain. MCR-2.2 antibiotic_resistance ARO:3004502 MCR-2.2 An MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in Great Britain. PMID:29091193 PMID:29091227 MCR-2.2 An MCR-3 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Aeromonas. MCR-3.6 antibiotic_resistance ARO:3004503 MCR-3.6 An MCR-3 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Aeromonas. PMID:29394397 MCR-3.6 An MCR-3 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from Aeromonas, Proteus and Escherichia coli. MCR-3.10 antibiotic_resistance ARO:3004504 MCR-3.10 An MCR-3 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from Aeromonas, Proteus and Escherichia coli. PMID:29203482 MCR-3.10 An MCR-3 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from an extensively-resistant Escherichia coli clinical isolate. MCR-3.5 antibiotic_resistance ARO:3004505 MCR-3.5 An MCR-3 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from an extensively-resistant Escherichia coli clinical isolate. PMID:28971871 PMID:30053115 MCR-3.5 An MCR-1 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from an Escherichia porcine isolate in Great Britain. MCR-1.10 antibiotic_resistance ARO:3004506 MCR-1.10 An MCR-1 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from an Escherichia porcine isolate in Great Britain. PMID:29091227 MCR-1.10 An MCR-1 phosphoethanolamine transferase and polymyxin resistance gene variant identified from an enterotoxigenic Escherichia coli clinical isolate. MCR-1.9 antibiotic_resistance ARO:3004507 MCR-1.9 An MCR-1 phosphoethanolamine transferase and polymyxin resistance gene variant identified from an enterotoxigenic Escherichia coli clinical isolate. PMID:29922243 MCR-1.9 An MCR-3 polymyxin (incl. colistin) resistance gene variant isolated from an Aeromonas isolate. MCR-3.9 antibiotic_resistance ARO:3004508 MCR-3.9 An MCR-3 polymyxin (incl. colistin) resistance gene variant isolated from an Aeromonas isolate. PMID:29394397 MCR-3.9 An MCR-3 polymyxin (incl. colistin) resistance gene variant identified from an Aeromonas isolate. MCR-3.8 antibiotic_resistance ARO:3004509 MCR-3.8 An MCR-3 polymyxin (incl. colistin) resistance gene variant identified from an Aeromonas isolate. PMID:29394397 MCR-3.8 An MCR polymyxin (colistin) resistance gene variant identified in Aeromonas. MCR-3.7 antibiotic_resistance ARO:3004510 MCR-3.7 An MCR polymyxin (colistin) resistance gene variant identified in Aeromonas. PMID:29394397 MCR-3.7 An MCR-3 polymyxin resistance gene variant identified in a colistin-resistant Salmonella isolate from Canada, located on an IncHI-2 plasmid. MCR-3.2 antibiotic_resistance ARO:3004511 MCR-3.2 An MCR-3 polymyxin resistance gene variant identified in a colistin-resistant Salmonella isolate from Canada, located on an IncHI-2 plasmid. PMID:30351266 MCR-3.2 An MCR-1 polymyxin resistance gene variant identified from colistin-resistant Salmonella enterica (serovar typhimurium) isolate, carried by an IncP plasmid. MCR-1.6 antibiotic_resistance ARO:3004513 MCR-1.6 An MCR-1 polymyxin resistance gene variant identified from colistin-resistant Salmonella enterica (serovar typhimurium) isolate, carried by an IncP plasmid. PMID:28264851 MCR-1.6 An MCR-1 polymyxin resistance gene variant identified from a poultry Raoultella planticola isolate. MCR-1.3 antibiotic_resistance ARO:3004514 MCR-1.3 An MCR-1 polymyxin resistance gene variant identified from a poultry Raoultella planticola isolate. PMID:28242671 PMID:29778190 MCR-1.3 An MCR-1 polymyxin resistance gene variant identified from a colistin-resistant Escherichia coli isolate. MCR-1.4 antibiotic_resistance ARO:3004515 MCR-1.4 An MCR-1 polymyxin resistance gene variant identified from a colistin-resistant Escherichia coli isolate. PMID:29118748 MCR-1.4 A novel phosphoethanolamine transferase and mobile colistin resistance gene identified from carbapenem-resistant NDM-1-producing Klebsiella pneumoniae. MCR-8.1 antibiotic_resistance ARO:3004516 MCR-8.1 A novel phosphoethanolamine transferase and mobile colistin resistance gene identified from carbapenem-resistant NDM-1-producing Klebsiella pneumoniae. PMID:29970891 MCR-8.1 A novel plasmid-mediated colistin-resistant phosphoethanolamine transferase identified from a poultry isolate of Klebsiella pneumoniae. MCR-7.1 antibiotic_resistance ARO:3004517 MCR-7.1 A novel plasmid-mediated colistin-resistant phosphoethanolamine transferase identified from a poultry isolate of Klebsiella pneumoniae. PMID:29912417 MCR-7.1 MIC sign (>, <, =) of the MIC value. antibiotic_resistance ARO:3004519 MIC sign Greater than MIC value. antibiotic_resistance ARO:3004520 > Less than MIC value. antibiotic_resistance ARO:3004521 < Equal to MIC value. antibiotic_resistance ARO:3004522 = MIC is a range of two MIC values (e.g., given 10 clinical isolates with a resistance determinant, there are 5 that have an MIC of 25ug/mL and 5 that have an MIC of 100ug/mL agaisnt tobramycin). antibiotic_resistance ARO:3004523 MIC range Strain type used for antibiotic susceptibility testing. antibiotic_resistance ARO:3004524 strain type Resistant determinant is identified in strain without any experimental methods. antibiotic_resistance ARO:3004525 resistance determinant in strain Experimental deletion of resistance determinant in the chromosome of the strain initially with this resistance determinant. antibiotic_resistance ARO:3004526 deletion of resistance determinant Experimental protocol where there is a deletion of resistance determinant and the transformation of a plasmid harbouring resistance determinant into the same strain. antibiotic_resistance ARO:3004527 deletion of resistance determinant with plasmid harbouring resistance determinant Experimental procedure where plasmid harbouring a resistance determinant is transformed into a strain. antibiotic_resistance ARO:3004528 plasmid harbouring resistance determinant Without any experimental protocol, the resistance determinant is absent from the strain. antibiotic_resistance ARO:3004529 resistance determinant not in strain Experimental insertion of resistance determinant in the chromosome of the strain initially without this resistance determinant. antibiotic_resistance ARO:3004530 insertion of resistance determinant Specific strain of bacteria that was used to perform the antibiotic susceptibility test. antibiotic_resistance ARO:3004531 strain Source of the strain used in the antibiotic susceptibility test (e.g., clinical, environmental, agriculture). antibiotic_resistance ARO:3004532 strain source Strain isolated in a clinical setting (e.g., from a patient). antibiotic_resistance ARO:3004533 clinical source Strain collected from environment (e.g., soil, water). antibiotic_resistance ARO:3004534 environmental source Strain collected from agricultural setting (e.g., chicken, pig). antibiotic_resistance ARO:3004535 agricultural source The control of the antibiotic susceptibility testing, whether there was an experimental control (same strain, with and without resistance determinant) or if there was a group of clinical isolates found to have a resistance determinant compared against a strain without that resistance determinant. antibiotic_resistance ARO:3004536 antimicrobial susceptibility test control Antimicrobial susceptibility testing was performed on the same strain with and without a resistance determinant. antibiotic_resistance ARO:3004537 experimental control Antibiotic susceptibility testing is performed on a group of clinical isolates with a resistance determinant compared to different strains that do not have this resistance determinant. No experiment was performed to delete / insert the resistance determinant to determine antibiotic susceptibility using the same genetic background. antibiotic_resistance ARO:3004538 correlative control A chromosomal macrolide 2'-phosphotransferase and resistance gene identified from a Brachybacterium faecium cave isolate. mphH antibiotic_resistance ARO:3004539 mphH A chromosomal macrolide 2'-phosphotransferase and resistance gene identified from a Brachybacterium faecium cave isolate. PMID:22509370 PMID:29317655 mphH Source is an experimental, commonly used lab strain (e.g., P. aeruginosa PAO1). antibiotic_resistance ARO:3004540 experimental source A chromosomal macrolide phosphotransferase identified from Bacillus subtilis. mphK antibiotic_resistance ARO:3004541 mphK A chromosomal macrolide phosphotransferase identified from Bacillus subtilis. PMID:29317655 mphK A macrolide phosphotransferase identified on a plasmid in Exiguobacterium. mphN antibiotic_resistance ARO:3004542 mphN A macrolide phosphotransferase identified on a plasmid in Exiguobacterium. PMID:24362420 PMID:29317655 mphN A chromosomal macrolide phosphostransferase identified in Brachybacterium paraconglomeratum. mphO antibiotic_resistance ARO:3004543 mphO A chromosomal macrolide phosphostransferase identified in Brachybacterium paraconglomeratum. PMID:22509370 PMID:29317655 mphO A chromosomal macrolide phosphotransferase identified in Brevibacillus brevis VM4. mphJ antibiotic_resistance ARO:3004544 mphJ A chromosomal macrolide phosphotransferase identified in Brevibacillus brevis VM4. PMID:29259290 PMID:29317655 mphJ ADC beta-lactamase enzymes with demonstrable carbapenemase activity, an exception amongst these enzymes. antibiotic_resistance ARO:3004545 ADC beta-lactamase with carbapenemase activity ADC beta-lactamase enzymes with demonstrable carbapenemase activity, an exception amongst these enzymes. PMID:25372683 Point mutations in the 23S ribosomal RNA domain of Campylobacter jejuni which confer resistance to macrolide antibiotics, including erythromycin. Cjej_23S_ERY antibiotic_resistance ARO:3004546 Campylobacter jejuni 23S rRNA with mutation conferring resistance to erythromycin Point mutations in the 23S ribosomal RNA domain of Campylobacter jejuni which confer resistance to macrolide antibiotics, including erythromycin. PMID:12604552 Cjej_23S_ERY A dihydrofolate reductase and antibiotic resistance gene identified from an integron in Vibrio cholerae. dfr6 dfrA6 antibiotic_resistance ARO:3004547 dfrA6 A dihydrofolate reductase and antibiotic resistance gene identified from an integron in Vibrio cholerae. PMID:19704128 dfrA6 A dihydrofolate reductase and trimethoprim resistance gene identified from porcine isolates of Esherichia coli. dfr9 dfrA9 dfrIX antibiotic_resistance ARO:3004548 dfrA9 A dihydrofolate reductase and trimethoprim resistance gene identified from porcine isolates of Esherichia coli. PMID:1659308 dfrA9 A dihydrofolate reductase and trimethoprim resistance gene identified from an integron in Pseudomonas aeruginosa. dfr-lie dfrB5 antibiotic_resistance ARO:3004549 dfrB5 A dihydrofolate reductase and trimethoprim resistance gene identified from an integron in Pseudomonas aeruginosa. PMID:16048978 dfrB5 A dihydrofolate reductase and trimethoprim resistance gene from non-O1, non-O139 Vibrio cholerae. dfrA27 antibiotic_resistance ARO:3004550 dfrA27 A dihydrofolate reductase and trimethoprim resistance gene from non-O1, non-O139 Vibrio cholerae. PMID:25870070 dfrA27 A dihydrofolate reductase and trimethoprim resistance gene from Aeromonas hydrophilia. dfrA28 antibiotic_resistance ARO:3004551 dfrA28 A dihydrofolate reductase and trimethoprim resistance gene from Aeromonas hydrophilia. PMID:21764945 dfrA28 A dihydrofolate reductase and trimethoprim resistance gene from Klebsiella pneumoniae. dfrA30 antibiotic_resistance ARO:3004552 dfrA30 A dihydrofolate reductase and trimethoprim resistance gene from Klebsiella pneumoniae. PMID:21595893 dfrA30 A dihydrofolate reductase and trimethoprim resistance gene isolated from canine Escherichia coli infection. dfrA29 antibiotic_resistance ARO:3004554 dfrA29 A dihydrofolate reductase and trimethoprim resistance gene isolated from canine Escherichia coli infection. PMID:27302904 dfrA29 A dihydrofolate reductase and trimethoprim resistance gene identified from non-typhoidal multidrug-resistant Salmonella enterica. dfrA32 antibiotic_resistance ARO:3004555 dfrA32 A dihydrofolate reductase and trimethoprim resistance gene identified from non-typhoidal multidrug-resistant Salmonella enterica. PMID:19921331 dfrA32 A dihydrofolate reductase and trimethoprim resistance gene identified on an integron in multidrug-resistant gram-negative bacteria. dfrB7 dfrB8 antibiotic_resistance ARO:3004556 dfrB7 A dihydrofolate reductase and trimethoprim resistance gene identified on an integron in multidrug-resistant gram-negative bacteria. PMID:21627486 dfrB7 CAM (Central Alberta Metallo) beta-lactamases are class B metallo-beta-lactamases and carbapenemases found to confer resistance to broad spectrum antibiotics in Pseudomonas aeruginosa. antibiotic_resistance ARO:3004558 CAM beta-lactamase CAM (Central Alberta Metallo) beta-lactamases are class B metallo-beta-lactamases and carbapenemases found to confer resistance to broad spectrum antibiotics in Pseudomonas aeruginosa. PMID:30789204 CAM-1 is a CAM (Central Alberta Metallo) beta-lactamase and carbapenemase identified from 4 clinical isolates of Pseudomonas aeruginosa from a Canadian hospital. CAM-1 antibiotic_resistance ARO:3004559 CAM-1 CAM-1 is a CAM (Central Alberta Metallo) beta-lactamase and carbapenemase identified from 4 clinical isolates of Pseudomonas aeruginosa from a Canadian hospital. PMID:30789204 CAM-1 murG acetylglucosaminyltransferase enzymes inhibited by vancomycin. Mutations in murG confer resistance to vancomycin through antibiotic target alteration. antibiotic_resistance ARO:3004560 murG transferase murG acetylglucosaminyltransferase enzymes inhibited by vancomycin. Mutations in murG confer resistance to vancomycin through antibiotic target alteration. PMID:23887866 Mutations in murG which confer resistance to vancomycin in Clostridioides difficile. Cdif_murG_VAN antibiotic_resistance ARO:3004561 Clostridioides difficile murG with mutation conferring resistance to vancomycin Mutations in murG which confer resistance to vancomycin in Clostridioides difficile. PMID:23887866 Cdif_murG_VAN Point mutations in gyrB of Clostridioides difficile conferring resistance to fluoroquinolone antibiotics. Cdif_gyrB_FLO antibiotic_resistance ARO:3004562 Clostridioides difficile gyrB conferring resistance to fluoroquinolones Point mutations in gyrB of Clostridioides difficile conferring resistance to fluoroquinolone antibiotics. PMID:12384345 PMID:18480338 PMID:20226332 PMID:22508299 PMID:27842877 Cdif_gyrB_FLO Point mutations in the rpoB region of Clostridioides difficile which confer resistance to rifampin and rifampicin antibiotics. Cdif_rpoB_RIF antibiotic_resistance ARO:3004563 Clostridioides difficile rpoB with mutation conferring resistance to rifampicin Point mutations in the rpoB region of Clostridioides difficile which confer resistance to rifampin and rifampicin antibiotics. PMID:18559647 PMID:19140738 PMID:21998414 PMID:22361457 PMID:22908175 PMID:23887866 PMID:29383668 Cdif_rpoB_RIF Resistance-modifying agent (RMA) without characterized mechanism which do not exhibit antibiotic activity on their own, but improve the performance of antibiotic drugs. antibiotic_resistance ARO:3004564 unclassified resistance-modifying agents Resistance-modifying agent (RMA) without characterized mechanism which do not exhibit antibiotic activity on their own, but improve the performance of antibiotic drugs. PMID:27657810 PMID:29264917 A class of resistance-modifying agents and beta-lactam potentiators which selectively potentiate beta-lactam antibiotics, specifically Amoxicillin-clavulanic acid, in methicillin-resistant Staphylococcus aureus (MRSA) without their own antimicrobial activity. antibiotic_resistance ARO:3004565 tetracyclic indoline A class of resistance-modifying agents and beta-lactam potentiators which selectively potentiate beta-lactam antibiotics, specifically Amoxicillin-clavulanic acid, in methicillin-resistant Staphylococcus aureus (MRSA) without their own antimicrobial activity. PMID:27657810 Rifalazil is a rifamycin derivative antibiotic, sometimes used for treating Clostridioides difficile infections. pubchem.compound:135431094 antibiotic_resistance ARO:3004566 Rifalazil Rifalazil is a rifamycin derivative antibiotic, sometimes used for treating Clostridioides difficile infections. PMID:12556219 Ramoplanin is a glycolipodepsipeptide antibiotic derived from gram-positive Actinoplanes used to treat infection with Clostridioides difficile. pubchem.compound:16132338 antibiotic_resistance ARO:3004567 Ramoplanin Ramoplanin is a glycolipodepsipeptide antibiotic derived from gram-positive Actinoplanes used to treat infection with Clostridioides difficile. PMID:25182650 A trimethoprim-resistant dihydrofolate reductase identified from Vibrio cholerae. dfr18 dfrA18 antibiotic_resistance ARO:3004568 dfrA18 A trimethoprim-resistant dihydrofolate reductase identified from Vibrio cholerae. PMID:11600347 dfrA18 A chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella osloensis. ICR-Mo represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases. ICR-Mo antibiotic_resistance ARO:3004569 ICR-Mo A chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella osloensis. ICR-Mo represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases. PMID:29758020 ICR-Mo PNGM is a family of metallo-beta-lactamases first identified from a deep-sea sediment metagenome and shown to reduce antibiotic susceptibility by hydrolysis of penicillins, carbapenems and extended- and broad-spectrum cephalosporins. antibiotic_resistance ARO:3004570 PNGM beta-lactamase PNGM is a family of metallo-beta-lactamases first identified from a deep-sea sediment metagenome and shown to reduce antibiotic susceptibility by hydrolysis of penicillins, carbapenems and extended- and broad-spectrum cephalosporins. PMID:29842976 PNGM-1 is a subclass B3 metallo-beta-lactamase first identified from a deep-sea sediment meta-genome. PNGM-1 is shown to reduce susceptibility to extended- and broad-spectrum cephalosporins, carbapenems, and penicillins. PNGM-1 is a novel metallo-beta-lactamase which predates the current antibiotic era. PNGM-1 antibiotic_resistance ARO:3004571 PNGM-1 PNGM-1 is a subclass B3 metallo-beta-lactamase first identified from a deep-sea sediment meta-genome. PNGM-1 is shown to reduce susceptibility to extended- and broad-spectrum cephalosporins, carbapenems, and penicillins. PNGM-1 is a novel metallo-beta-lactamase which predates the current antibiotic era. PMID:29842976 PNGM-1 MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid. A0A3M7YRP9 A0A3P0BBR7 F6MF49 Saur_LmrS antibiotic_resistance ARO:3004572 Staphylococcus aureus LmrS MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid. PMID:20855745 Saur_LmrS Expression of abaF in E. coli resulted in increased resistance to fosfomycin. Abau_AbaF P0DPR5 antibiotic_resistance ARO:3004573 Acinetobacter baumannii AbaF Expression of abaF in E. coli resulted in increased resistance to fosfomycin. PMID:27650185 Abau_AbaF AbaQ is an MFS transporter mainly involved in the extrusion of quinolone-type drugs in A. baumannii. Abau_AbaQ P0DPR4 antibiotic_resistance ARO:3004574 Acinetobacter baumannii AbaQ AbaQ is an MFS transporter mainly involved in the extrusion of quinolone-type drugs in A. baumannii. PMID:29941648 Abau_AbaQ Members of the radical SAM superfamily are involved in a wide variety of reactions, including unusual methylations, isomerization, sulfur insertion, ring formation, anaerobic oxidation, and protein radical formation. antibiotic_resistance ARO:3004575 S-adenosylmethionine (SAM) superfamily A tetracycline-resistance ribosomal protection protein. tet(61) antibiotic_resistance ARO:3004576 tet(61) A tetracycline-resistance ribosomal protection protein. PMID:33866063 tet(61) AmvA has 14 alpha-helical transmembrane segments, qualifying it as a member of the DHA2 transporter family of the major facilitator superfamily (MFS). When AmvA was expressed in E. coli, the cells had at least four-fold decreased susceptibility to erythromycin, acridine orange, acriflavine, deoxycholate and methyl viologen. AmvA from the AC0037 strain of A. baumannii was tested. Abau_AmvA B0V737 antibiotic_resistance ARO:3004577 Acinetobacter baumannii AmvA AmvA has 14 alpha-helical transmembrane segments, qualifying it as a member of the DHA2 transporter family of the major facilitator superfamily (MFS). When AmvA was expressed in E. coli, the cells had at least four-fold decreased susceptibility to erythromycin, acridine orange, acriflavine, deoxycholate and methyl viologen. AmvA from the AC0037 strain of A. baumannii was tested. PMID:20573661 Abau_AmvA AbuO is akin to the TolC outer membrane efflux protein. Deletion in A. baumannii results in increased susceptibility to antibiotics including amikacin, carbenicillin, ceftriaxone, meropenem, streptomycin, and tigecycline as well as disinfectants benzyalkonium chloride and chlorhexidine. A0A225SC95 Abau_AbuO Q2FD57 antibiotic_resistance ARO:3004578 Acinetobacter baumannii AbuO AbuO is akin to the TolC outer membrane efflux protein. Deletion in A. baumannii results in increased susceptibility to antibiotics including amikacin, carbenicillin, ceftriaxone, meropenem, streptomycin, and tigecycline as well as disinfectants benzyalkonium chloride and chlorhexidine. PMID:25512405 Abau_AbuO KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. A6T8S5 Kpne_KpnE antibiotic_resistance ARO:3004580 Klebsiella pneumoniae KpnE KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. PMID:23836167 Kpne_KpnE A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(48) antibiotic_resistance ARO:3004581 tet(48) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(48) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(49) antibiotic_resistance ARO:3004582 tet(49) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(49) KpnF subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. A6T8S6 Kpne_KpnF antibiotic_resistance ARO:3004583 Klebsiella pneumoniae KpnF KpnF subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. PMID:23836167 Kpne_KpnF A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(50) antibiotic_resistance ARO:3004584 tet(50) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(50) KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. antibiotic_resistance ARO:3004585 Klebsiella pneumoniae KpnEF KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. PMID:23836167 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(51) antibiotic_resistance ARO:3004586 tet(51) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(51) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(52) antibiotic_resistance ARO:3004587 tet(52) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(52) KpnG consists of ~390 residues and resembles EmrA of E. coli. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. C8T8U1 Kpne_KpnG antibiotic_resistance ARO:3004588 Klebsiella pneumoniae KpnG KpnG consists of ~390 residues and resembles EmrA of E. coli. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. PMID:24823362 Kpne_KpnG A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(53) antibiotic_resistance ARO:3004589 tet(53) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(53) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(54) antibiotic_resistance ARO:3004590 tet(54) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(54) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(55) antibiotic_resistance ARO:3004591 tet(55) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(55) erm(32) is a rRNA methyltransferase. Encodes methyltransferases that modify 23S rRNA. erm(32) antibiotic_resistance ARO:3004592 erm(32) erm(32) is a rRNA methyltransferase. Encodes methyltransferases that modify 23S rRNA. PMID:10348045 erm(32) Erm45 is an rRNA methylase that confers resistances to macrolide, lincosamide, and streptogramin B. erm(45) antibiotic_resistance ARO:3004595 erm(45) Erm45 is an rRNA methylase that confers resistances to macrolide, lincosamide, and streptogramin B. PMID:25779586 erm(45) erm(46) is transferable determinant that confers resistance to macrolides. ErmREQ erm(46) antibiotic_resistance ARO:3004596 erm(46) erm(46) is transferable determinant that confers resistance to macrolides. PMID:26377866 erm(46) KpnH consists of ~511 residues, resembles EmrB of E. coli, and is probably a translocase in the KpnGH-TolC efflux protein in K. pneumoniae. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. A0A3F3BH25 Kpne_KpnH antibiotic_resistance ARO:3004597 Klebsiella pneumoniae KpnH KpnH consists of ~511 residues, resembles EmrB of E. coli, and is probably a translocase in the KpnGH-TolC efflux protein in K. pneumoniae. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. PMID:24823362 Kpne_KpnH Disruption of the pump components KpnGH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. antibiotic_resistance ARO:3004598 Klebsiella pneumoniae KpnGH-TolC Disruption of the pump components KpnGH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. PMID:24823362 clcD gene can provide resistance to representatives of five of the six antibiotic groups previously shown to be affected by Cfr. clcD was originally found in Clostridioides difficile and is cfr-like. clcD antibiotic_resistance ARO:3004599 clcD clcD gene can provide resistance to representatives of five of the six antibiotic groups previously shown to be affected by Cfr. clcD was originally found in Clostridioides difficile and is cfr-like. PMID:26149991 clcD LnuH is a lincosamide nucleotidyltransferase transferase. LnuH antibiotic_resistance ARO:3004600 LnuH LnuH is a lincosamide nucleotidyltransferase transferase. PMID:28843817 LnuH LnuP is a lincosamide nucleotidyltransferase major efflux facilitator. LnuP antibiotic_resistance ARO:3004601 LnuP LnuP is a lincosamide nucleotidyltransferase major efflux facilitator. PMID:19684139 LnuP A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(56) antibiotic_resistance ARO:3004603 tet(56) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(56) ermZ is an methyltransferase modifying 23S rRNA conferring resistance to Spiramycin. ermZ srm7 srmD antibiotic_resistance ARO:3004605 ermZ ermZ is an methyltransferase modifying 23S rRNA conferring resistance to Spiramycin. PMID:18048924 ermZ erm(40) is an adenine RNA methylase and confers intrinsic resistance in Mycobacteria. erm(40) antibiotic_resistance ARO:3004606 erm(40) erm(40) is an adenine RNA methylase and confers intrinsic resistance in Mycobacteria. PMID:17005837 erm(40) The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. cfr(A) Group antibiotic_resistance ARO:3004607 Cfr Group The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. PMID:28663118 EreD is an erythromycin esterase protein. Ere(D) EreD antibiotic_resistance ARO:3004608 EreD EreD is an erythromycin esterase protein. PMID:26107936 EreD The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. antibiotic_resistance ARO:3004609 cfr(B) Group The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. PMID:28663118 The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. antibiotic_resistance ARO:3004610 cfr(C) Group The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. PMID:28663118 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(47) tet47 antibiotic_resistance ARO:3004613 tet(47) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(47) ADC-11 is a class C beta-lactamase found in Acinetobacter baumannii. ADC-11 antibiotic_resistance ARO:3004615 ADC-11 ADC-11 Mycoplasma genitalium strain M6320 contains mutations that lead to resistance to fluoroquinolone and macrolide antibiotics. Mgen_23S_MULT antibiotic_resistance ARO:3004616 Mycoplasma genitalium 23S rRNA mutations confers resistance to fluoroquinolone and macrolide antibiotics Mycoplasma genitalium strain M6320 contains mutations that lead to resistance to fluoroquinolone and macrolide antibiotics. PMID:18990060 PMID:22532861 PMID:23658265 Mgen_23S_MULT An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. ADC-30 antibiotic_resistance ARO:3004617 ADC-30 ADC-30 An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. ADC-58 antibiotic_resistance ARO:3004618 ADC-58 ADC-58 An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. ADC-59 antibiotic_resistance ARO:3004619 ADC-59 ADC-59 An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. ADC-60 antibiotic_resistance ARO:3004620 ADC-60 ADC-60 AAC(3)-IIe is a plasmid-encoded aminoglycoside acetyltransferase in E. coli. AAC(3)-IIe aacC2e antibiotic_resistance ARO:3004621 AAC(3)-IIe AAC(3)-IIe is a plasmid-encoded aminoglycoside acetyltransferase in E. coli. PMID:20185552 AAC(3)-IIe QnrS10 is a plasmid-mediated quinolone resistance protein. QnrS10 antibiotic_resistance ARO:3004622 QnrS10 QnrS10 is a plasmid-mediated quinolone resistance protein. PMID:23648253 QnrS10 AAC(3)-IId is a plasmid-encoded aminoglycoside acetyltransferase in E. coli. AAC(3)-IId aacC2d antibiotic_resistance ARO:3004623 AAC(3)-IId AAC(3)-IId is a plasmid-encoded aminoglycoside acetyltransferase in E. coli. PMID:20185552 AAC(3)-IId QnrS11 is a plasmid-mediated quinolone resistance protein. QnrS11 antibiotic_resistance ARO:3004624 QnrS11 QnrS11 is a plasmid-mediated quinolone resistance protein. PMID:22470007 QnrS11 QnrS12 is a plasmid-mediated quinolone resistance protein. QnrS12 antibiotic_resistance ARO:3004625 QnrS12 QnrS12 is a plasmid-mediated quinolone resistance protein. PMID:29415140 QnrS12 Erm(49) is an rRNA methylase gene. Erm(49) antibiotic_resistance ARO:3004626 Erm(49) Erm(49) is an rRNA methylase gene. PMID:23882264 PMID:29500262 Erm(49) QnrS15 is a plasmid-mediated quinolone resistance protein. QnrS15 antibiotic_resistance ARO:3004627 QnrS15 QnrS15 is a plasmid-mediated quinolone resistance protein. PMID:29415140 QnrS15 AAC(2')-IIa is a kasugamycin 2' N-acetyltransferase protein found in Burkholderia glumae and Acidovorax avenae isolates. AAC(2')-IIa antibiotic_resistance ARO:3004628 AAC(2')-IIa AAC(2')-IIa is a kasugamycin 2' N-acetyltransferase protein found in Burkholderia glumae and Acidovorax avenae isolates. PMID:22660700 AAC(2')-IIa AAC(6')-Im is an aminoglycoside acetyltransferase encoded by plasmids in E. coli, and E. faecium. AAC(6')-Im antibiotic_resistance ARO:3004629 AAC(6')-Im AAC(6')-Im is an aminoglycoside acetyltransferase encoded by plasmids in E. coli, and E. faecium. PMID:11557456 AAC(6')-Im Mycoplasma genitalium exhibits multiple mutations in parC which confers resistance to Moxifloxacin. Mgen_parC_MXF antibiotic_resistance ARO:3004630 Mycoplasma genitalium parC mutations confers resistance to Moxifloxacin Mycoplasma genitalium exhibits multiple mutations in parC which confers resistance to Moxifloxacin. PMID:15728924 PMID:19567408 PMID:20580532 PMID:23658265 PMID:29883482 Mgen_parC_MXF Mycoplasma Genitalium GyrA mutations confers resistance to fluoroquinolones such as Moxifloxacin. Mgen_gyrA_FLO antibiotic_resistance ARO:3004631 Mycoplasma genitalium gyrA mutation confers resistance to fluoroquinolones Mycoplasma Genitalium GyrA mutations confers resistance to fluoroquinolones such as Moxifloxacin. PMID:14506049 PMID:15728924 PMID:23658265 PMID:29883482 Mgen_gyrA_FLO A class ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. ADC-62 antibiotic_resistance ARO:3004632 ADC-62 ADC-62 A class C beta-lactamase and cephalosporinase from Acinetobacter baumannii. ADC-67 antibiotic_resistance ARO:3004633 ADC-67 ADC-67 A class C ADC beta-lactamase and cephalosporinase found in Acinetobacter baumannii. ADC-73 antibiotic_resistance ARO:3004634 ADC-73 ADC-73 AAC(6')-Il is an aminoglycoside acetyltransferase encoded by plasmids and integrons in Enterobacter cloaecae and Klebsiella aerogenes. AAC(6')-Il aacA7 antibiotic_resistance ARO:3004635 AAC(6')-Il AAC(6')-Il is an aminoglycoside acetyltransferase encoded by plasmids and integrons in Enterobacter cloaecae and Klebsiella aerogenes. PMID:7793874 AAC(6')-Il qnrE1 is a member of the qnrE family of plasmid-borne (fluoro)quinolone-resistance genes, with chromosomal origins from Enterobacter spp. qnrE1 antibiotic_resistance ARO:3004636 qnrE1 qnrE1 is a member of the qnrE family of plasmid-borne (fluoro)quinolone-resistance genes, with chromosomal origins from Enterobacter spp. PMID:28193666 qnrE1 qnrE2 is a qnrE-member of plasmid-borne (fluoro)quinolone-resistance genes. qnrE2 antibiotic_resistance ARO:3004637 qnrE2 qnrE2 is a qnrE-member of plasmid-borne (fluoro)quinolone-resistance genes. PMID:34097486 qnrE2 AAC(6')-I-48 (AAC(6')-Iag) is an aminoglycoside acetyltransferase encoded by integrons in Pseudomonas aeruginosa. AAC(6')-I-48 AAC(6')-Iag aacA48 antibiotic_resistance ARO:3004638 AAC(6')-I-48 AAC(6')-I-48 (AAC(6')-Iag) is an aminoglycoside acetyltransferase encoded by integrons in Pseudomonas aeruginosa. PMID:23950962 AAC(6')-I-48 The tetAB genes of the Corynebacterium striatum R-plasmid encode an ABC transporter and confer tetracycline, oxytetracycline, and oxalic resistance. Cstr_tetA antibiotic_resistance ARO:3004639 Corynebacterium striatum tetA The tetAB genes of the Corynebacterium striatum R-plasmid encode an ABC transporter and confer tetracycline, oxytetracycline, and oxalic resistance. PMID:10732668 Cstr_tetA A dihydrofolate reductase found in Salmonella Enterica. dfrA15b antibiotic_resistance ARO:3004640 dfrA15b A dihydrofolate reductase found in Salmonella Enterica. PMID:15761062 dfrA15b AAC(6')-I-43 (aacA43) is an aminoglycoside acetyltransferase encoded by integrons found in Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloaecae. AAC(6')-I-43 antibiotic_resistance ARO:3004641 AAC(6')-I-43 AAC(6')-I-43 (aacA43) is an aminoglycoside acetyltransferase encoded by integrons found in Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloaecae. PMID:21422220 AAC(6')-I-43 A dihydrofolate reductase that confers resistance to trimethoprim. dfrA3b antibiotic_resistance ARO:3004642 dfrA3b A dihydrofolate reductase that confers resistance to trimethoprim. PMID:14638506 dfrA3b A 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(K) [Alkalihalobacillus halodurans]. Erm(K) antibiotic_resistance ARO:3004643 Erm(K) A 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(K) [Alkalihalobacillus halodurans]. PMID:1713206 Erm(K) dfrA6 is a dihydrofolate reductase that confers resistance to trimethoprim. Found in Proteus mirabilis. Pmir_dfrA6 antibiotic_resistance ARO:3004644 dfrA6 from Proteus mirabilis dfrA6 is a dihydrofolate reductase that confers resistance to trimethoprim. Found in Proteus mirabilis. PMID:1941991 Pmir_dfrA6 dfrI is a dihydrofolate reductase that is resistant to trimethoprim. dfrI antibiotic_resistance ARO:3004645 dfrI dfrI is a dihydrofolate reductase that is resistant to trimethoprim. PMID:17375195 dfrI AQU-2 is a chromosomally-encoded AQU class C beta-lactamase and cephalosporinase from Aeromonas. AQU-2 antibiotic_resistance ARO:3004647 AQU-2 AQU-2 AQU-3 is a chromosomally-encoded AQU class C beta-lactamase and cephalosporinase from. AQU-3 antibiotic_resistance ARO:3004648 AQU-3 AQU-3 cfr(B) has been observed in mobile genetic elements in E. faecium and Clostridioides difficile and confers resistance to linezolid, clindamycin, erythromycin, chloramphenicol, and retapamulin. cfr(B) antibiotic_resistance ARO:3004649 cfr(B) cfr(B) has been observed in mobile genetic elements in E. faecium and Clostridioides difficile and confers resistance to linezolid, clindamycin, erythromycin, chloramphenicol, and retapamulin. PMID:26248384 cfr(B) Initially reported as a tetracycline-resistant determinant encoded on the plasmid pKQ10 in Enterococcus faecium, tet(U) has since been determined to be a misannotation of a gene product not involved in tetracycline resistance. tetU antibiotic_resistance ARO:3004650 tet(U) Initially reported as a tetracycline-resistant determinant encoded on the plasmid pKQ10 in Enterococcus faecium, tet(U) has since been determined to be a misannotation of a gene product not involved in tetracycline resistance. PMID:22491689 PMID:8700968 Listeria monocytogenes EGD-e lin gene for lincomycin resistance ABC-F type ribosomal protection protein, complete CDS. lin antibiotic_resistance ARO:3004651 lin Listeria monocytogenes EGD-e lin gene for lincomycin resistance ABC-F type ribosomal protection protein, complete CDS. PMID:32615922 lin ErmO (gene lrm) lincomycin resistance methylase [Streptomyces lividans]. Erm(O)-lrm lrm antibiotic_resistance ARO:3004652 Erm(O)-lrm ErmO (gene lrm) lincomycin resistance methylase [Streptomyces lividans]. PMID:1761231 Erm(O)-lrm Class G tetracycline resistance determinant from Vibrio anguillarum. tetR(G) antibiotic_resistance ARO:3004653 tetR(G) Class G tetracycline resistance determinant from Vibrio anguillarum. PMID:1479961 tetR(G) SNP causing high-level ERY resistance and low-level CLI resistance. Cdif_23S_MULT antibiotic_resistance ARO:3004654 Clostridioides difficile 23S rRNA with mutation conferring resistance to erythromycin and clindamycin SNP causing high-level ERY resistance and low-level CLI resistance. PMID:17509804 Cdif_23S_MULT nimB is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimB antibiotic_resistance ARO:3004655 nimB nimB is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:10970359 PMID:8067736 nimB catII is a chloramphenicol acetyltransferase. This particular catII is found in E.coli K-12. Confers resistance to chloramphenicol. Ecol_catII antibiotic_resistance ARO:3004656 catII from Escherichia coli K-12 catII is a chloramphenicol acetyltransferase. This particular catII is found in E.coli K-12. Confers resistance to chloramphenicol. PMID:2268278 Ecol_catII catA4 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol. catA4 antibiotic_resistance ARO:3004657 catA4 catA4 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol. PMID:3900035 catA4 catA8 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol. catA8 antibiotic_resistance ARO:3004658 catA8 catA8 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol. PMID:11257023 PMID:11735367 PMID:9349809 catA8 NBU2-encoded resistance gene. An MefE homolog in Bacteroides species. Macrolide efflux MFS transporter. Mef(En2) antibiotic_resistance ARO:3004659 Mef(En2) NBU2-encoded resistance gene. An MefE homolog in Bacteroides species. Macrolide efflux MFS transporter. PMID:10852890 Mef(En2) catB11 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol. catB11 antibiotic_resistance ARO:3004660 catB11 catB11 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol. PMID:19416365 catB11 The Bacillus subtilis fosB gene encodes a fosfomycin resistance protein. Saur_FosB antibiotic_resistance ARO:3004661 Staphylococcus aureus FosB The Bacillus subtilis fosB gene encodes a fosfomycin resistance protein. PMID:11244082 Saur_FosB MCR-3.3 is a colistin resistance gene variant in the chromosome of an Aeromonas veronii. Conferred polymyxin resistance in both E. Coli and Aeromonas salmonicida. MCR-3.3 antibiotic_resistance ARO:3004662 MCR-3.3 MCR-3.3 is a colistin resistance gene variant in the chromosome of an Aeromonas veronii. Conferred polymyxin resistance in both E. Coli and Aeromonas salmonicida. PMID:28848017 MCR-3.3 A fusidic acid resistance determinant in Staphylococcus cohnii. This protein behaves akin to FusB as it is a FusB-type protein. It mediates dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. FusF antibiotic_resistance ARO:3004663 FusF A fusidic acid resistance determinant in Staphylococcus cohnii. This protein behaves akin to FusB as it is a FusB-type protein. It mediates dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. PMID:25313205 FusF cmlA8 is a plasmid that confers resistance to chloramphenicol. cmlA8 antibiotic_resistance ARO:3004665 cmlA8 cmlA8 is a plasmid that confers resistance to chloramphenicol. PMID:19107398 cmlA8 pexA is a florfenicol and chloramphenicol resistance gene discovered in Alaskan soil. pexA antibiotic_resistance ARO:3004666 pexA pexA is a florfenicol and chloramphenicol resistance gene discovered in Alaskan soil. PMID:20543056 pexA NorA gene cloned from Staphylococcus aureus conferred relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus and Escherichia coli. Had low or no resistance at all to hydrophobic ones such as nalidixic acid, oxolinic acid, and sparfloxacin in S. aureus and Escherichia coli. Saur_norA antibiotic_resistance ARO:3004667 Staphylococcus aureus norA NorA gene cloned from Staphylococcus aureus conferred relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus and Escherichia coli. Had low or no resistance at all to hydrophobic ones such as nalidixic acid, oxolinic acid, and sparfloxacin in S. aureus and Escherichia coli. PMID:2174864 Saur_norA Located on the chromosome of Aliivibrio salmonicida. Provides low-level resistance to quinolones. QnrAS antibiotic_resistance ARO:3004668 QnrAS Located on the chromosome of Aliivibrio salmonicida. Provides low-level resistance to quinolones. PMID:20947314 QnrAS A rRNA methyltransferase conferring high-level evernimicin resistance. emtA antibiotic_resistance ARO:3004669 emtA A rRNA methyltransferase conferring high-level evernimicin resistance. PMID:11580839 emtA Subtype of FosB, fosfomycin resistant. S.aureus SA1129 carried a FosB1 identical to S. haemolyticus. FosB1 antibiotic_resistance ARO:3004670 FosB1 Subtype of FosB, fosfomycin resistant. S.aureus SA1129 carried a FosB1 identical to S. haemolyticus. PMID:27144405 FosB1 Fosfomycin resistance gene. Shares a high homology with FosB1 and FosB3. FosB4 antibiotic_resistance ARO:3004671 FosB4 Fosfomycin resistance gene. Shares a high homology with FosB1 and FosB3. PMID:27144405 FosB4 Fosfomycin resistance gene. High homology with FosB1 and FosB3. FosB5 antibiotic_resistance ARO:3004672 FosB5 Fosfomycin resistance gene. High homology with FosB1 and FosB3. PMID:27144405 FosB5 Fosfomycin resistance gene. High homology with FosB1 and FosB3. FosB6 antibiotic_resistance ARO:3004673 FosB6 Fosfomycin resistance gene. High homology with FosB1 and FosB3. PMID:27144405 FosB6 A fosfomycin resistance gene. FosD antibiotic_resistance ARO:3004674 FosD A fosfomycin resistance gene. PMID:18539327 FosD Expression of cloned aphA15 gene in Escherichia coli reduced the susceptibility to kanamycin and neomycin, as well as to amikacin, netilmicin, and streptomycin. aphA15 antibiotic_resistance ARO:3004675 aphA15 Expression of cloned aphA15 gene in Escherichia coli reduced the susceptibility to kanamycin and neomycin, as well as to amikacin, netilmicin, and streptomycin. PMID:11257042 aphA15 The first allele of a 16S rRNA methyltransferase gene, rmtD2, confers a high resistance to all clinically available aminoglycosides. rmtD2 antibiotic_resistance ARO:3004677 rmtD2 The first allele of a 16S rRNA methyltransferase gene, rmtD2, confers a high resistance to all clinically available aminoglycosides. PMID:21078935 rmtD2 Aminoglycoside-resistance gene. rmtE antibiotic_resistance ARO:3004678 rmtE Aminoglycoside-resistance gene. PMID:20368404 rmtE A 16S rRNA mathyltransferase gene with a single nucleotide mutation compared to rmtE. rmtE2 antibiotic_resistance ARO:3004679 rmtE2 A 16S rRNA mathyltransferase gene with a single nucleotide mutation compared to rmtE. PMID:26392485 rmtE2 APH(3')-VIIIa is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides found in Streptomyces rimosus. APH(3')-VIIIa antibiotic_resistance ARO:3004680 APH(3')-VIIIa APH(3')-VIIIa is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides found in Streptomyces rimosus. PMID:23240563 APH(3')-VIIIa Point mutations in the rpoC region of Clostridioides difficile which confer resistance to vancomycin. Cdif_rpoC_VAN antibiotic_resistance ARO:3004681 Clostridioides difficile rpoC with mutation conferring resistance to vancomycin Point mutations in the rpoC region of Clostridioides difficile which confer resistance to vancomycin. PMID:23887866 Cdif_rpoC_VAN Small mobilizable plasmid pALWED1.8 containing a novel variant of the streptomycin/spectinomycin resistance gene. aadA27 antibiotic_resistance ARO:3004682 aadA27 Small mobilizable plasmid pALWED1.8 containing a novel variant of the streptomycin/spectinomycin resistance gene. PMID:26896789 aadA27 A novel Tn4551 streptomycin-resistance gene that was phenotypically silent in wild-type Bacteroides; expression could be activated by a trans-acting chromosomal mutation. aadS antibiotic_resistance ARO:3004683 aadS A novel Tn4551 streptomycin-resistance gene that was phenotypically silent in wild-type Bacteroides; expression could be activated by a trans-acting chromosomal mutation. PMID:1328814 aadS A mobilized and plasmid-mediated colistin resistance gene and phosphoethanolamine transferase identified from a Salmonella enterica isolate. MCR-9 MCR-9.1 antibiotic_resistance ARO:3004684 MCR-9.1 A mobilized and plasmid-mediated colistin resistance gene and phosphoethanolamine transferase identified from a Salmonella enterica isolate. PMID:31064835 MCR-9.1 A plasmid-mediated MCR-1 variant identified from polyclonal clinical Escherichia coli. MCR-1.5 antibiotic_resistance ARO:3004685 MCR-1.5 A plasmid-mediated MCR-1 variant identified from polyclonal clinical Escherichia coli. PMID:28678874 MCR-1.5 A plasmid-mediated MCR-1 variant identified from Escherichia coli. MCR-1.7 antibiotic_resistance ARO:3004686 MCR-1.7 A plasmid-mediated MCR-1 variant identified from Escherichia coli. PMID:29118748 MCR-1.7 An unpublished MCR-1 variant included in NCBI and indicated by Partridge et al. 2018. MCR-1.8 antibiotic_resistance ARO:3004687 MCR-1.8 An unpublished MCR-1 variant included in NCBI and indicated by Partridge et al. 2018. PMID:30053115 MCR-1.8 A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli as conferring resistance to colistin antibiotics. MCR-1.11 antibiotic_resistance ARO:3004688 MCR-1.11 A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli as conferring resistance to colistin antibiotics. PMID:30053115 MCR-1.11 A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli and conferring resistance to colistin antibiotics. MCR-1.12 antibiotic_resistance ARO:3004689 MCR-1.12 A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli and conferring resistance to colistin antibiotics. PMID:29052266 PMID:30053115 MCR-1.12 A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli. MCR-1.13 antibiotic_resistance ARO:3004690 MCR-1.13 A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli. PMID:30053115 MCR-1.13 A plasmid-mediated MCR-3.1 variant. MCR-3.4 antibiotic_resistance ARO:3004691 MCR-3.4 A plasmid-mediated MCR-3.1 variant. PMID:30053115 MCR-3.4 aadA10 is a aminoglycoside nucleotidyltransferase gene encoded by plasmids in P. aeruginosa. aadA10 antibiotic_resistance ARO:3004692 aadA10 aadA10 is a aminoglycoside nucleotidyltransferase gene encoded by plasmids in P. aeruginosa. PMID:12121911 aadA10 A plasmid-mediated phosphoethanolamine transferase and MCR-3 variant conferring resistance to colistin antibiotics. MCR-3.12 antibiotic_resistance ARO:3004693 MCR-3.12 A plasmid-mediated phosphoethanolamine transferase and MCR-3 variant conferring resistance to colistin antibiotics. PMID:29712655 PMID:30053115 MCR-3.12 A plasmid-mediated MCR-4 variant which confers resistance to colistin antibiotics. MCR-4.2 antibiotic_resistance ARO:3004694 MCR-4.2 A plasmid-mediated MCR-4 variant which confers resistance to colistin antibiotics. PMID:29635007 PMID:30053115 MCR-4.2 A plasmid-mediated MCR-4 variant and colistin resistance gene from clinical Enterobacteriaceae. MCR-4.3 antibiotic_resistance ARO:3004695 MCR-4.3 A plasmid-mediated MCR-4 variant and colistin resistance gene from clinical Enterobacteriaceae. PMID:29237785 PMID:30053115 MCR-4.3 A plasmid-mediated MCR-4 variant and colistin resistance gene. MCR-4.4 antibiotic_resistance ARO:3004696 MCR-4.4 A plasmid-mediated MCR-4 variant and colistin resistance gene. PMID:29635007 PMID:30053115 MCR-4.4 A plasmid-mediated MCR-4 variant and colistin resistance gene. MCR-4.5 antibiotic_resistance ARO:3004697 MCR-4.5 A plasmid-mediated MCR-4 variant and colistin resistance gene. PMID:29635007 PMID:30053115 MCR-4.5 A plasmid-mediated MCR-5 variant from Escheichia coli which confers resistance to colistin antibiotics. MCR-5.2 antibiotic_resistance ARO:3004698 MCR-5.2 A plasmid-mediated MCR-5 variant from Escheichia coli which confers resistance to colistin antibiotics. PMID:29444245 PMID:30053115 MCR-5.2 Streptothricin acetyltransferase gene (STAT gene) that confers streptothricin resistance on Escherichia coli and Bacillus subtilis. sta antibiotic_resistance ARO:3004699 sta Streptothricin acetyltransferase gene (STAT gene) that confers streptothricin resistance on Escherichia coli and Bacillus subtilis. PMID:3106324 sta Mutation in a resistance determinant rendering it non-functional. antibiotic_resistance ARO:3004700 mutation in resistance determinant An antibiotic cocktail containing beta-lactam penam antibiotic cloxacillin and the cephalosporin ceftazidime. antibiotic_resistance ARO:3004701 ceftazidime-cloxacillin An antibiotic cocktail containing the cephalosporin cefepime and the penicillin cloxacillin. antibiotic_resistance ARO:3004702 cefepime-cloxacillin An antibiotic cocktail containing beta-lactam penam antibiotic cloxacillin and the beta-lactam carbapenam antibiotic imipenam. antibiotic_resistance ARO:3004703 imipenem-cloxacillin aadA8b is an aminoglycoside nucleotidyltransferase gene encoded by plasmids in E. coli; can be created by a recombination event between aadA1 and aadA2. aadA8b antibiotic_resistance ARO:3004704 aadA8b aadA8b is an aminoglycoside nucleotidyltransferase gene encoded by plasmids in E. coli; can be created by a recombination event between aadA1 and aadA2. PMID:16291869 aadA8b An antibiotic cocktail containing the cephalosporin antibiotic ceftazidime and the beta-lactamase inhibitor clavulanic acid. pubchem.compound:9575352 ceftazidime-clavulanate antibiotic_resistance ARO:3004705 ceftazidime-clavulanic acid Experimental protocol where there is a mutation of resistance determinant and the transformation of a plasmid harbouring resistance determinant into the same strain. antibiotic_resistance ARO:3004706 mutation in resistance determinant with plasmid harbouring resistance determinant An antibiotic cocktail containing the cephamycin antibiotic cefoxitin and the beta-lactamase inhibitor clavulanate. antibiotic_resistance ARO:3004707 cefoxitin-clavulanate An antibiotic cocktail containing the cephamycin antibiotic cefoxitin and the beta-lactamase inhibitor sulbactam. antibiotic_resistance ARO:3004708 cefoxitin-sulbactam An antibiotic cocktail containing the cephamycin antibiotic cefoxitin and the beta-lactamase inhibitor tazobactam. antibiotic_resistance ARO:3004709 cefoxitin-tazobactam An antibiotic cocktail containing the cephalosporin antibiotic cefotaxime and the beta-lactamase inhibitor clavulanic acid. cefotaxime-clavulante antibiotic_resistance ARO:3004710 cefotaxime-clavulanic acid An antibiotic cocktail containing the cephalosporin antibiotic cefotaxime and the beta-lactamase inhibitor Tazobactam. antibiotic_resistance ARO:3004711 cefotaxime-tazobactam An antibiotic cocktail containing the cephalosporin antibiotic ceftazidime and the beta-lactamase inhibitor tazobactam. antibiotic_resistance ARO:3004712 ceftazidime-tazobactam An antibiotic cocktail containing the beta-lactam antibiotic aztreonam and the conjugate base of the beta-lactamase inhibitor clavulanic acid (clavulanate). aztreonam-clavulanic acid antibiotic_resistance ARO:3004713 aztreonam-clavulanate An antibiotic cocktail containing the beta-lactam antibiotic aztreonam and the beta-lactamase inhibitor tazobactam. antibiotic_resistance ARO:3004714 aztreonam-tazobactam vga(E) gene variant that confers resistance to pleuromutilins, lincosamides and streptogramin A antibiotics in staphylococci. Scoh_vga(E) antibiotic_resistance ARO:3004715 vga(E) Staphylococcus cohnii vga(E) gene variant that confers resistance to pleuromutilins, lincosamides and streptogramin A antibiotics in staphylococci. PMID:24324222 Scoh_vga(E) Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. antibiotic_resistance ARO:3004716 Vanillobiocin Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. PMID:15152806 Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. different from vanillobiocin by the [psition of the pyrrole unit attached to the sugar moiety of the antibiotic. antibiotic_resistance ARO:3004717 Isovanillobiocin Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. different from vanillobiocin by the [psition of the pyrrole unit attached to the sugar moiety of the antibiotic. PMID:15152806 Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. Declovanillobiocin lacks the chlorine atom at the aminocoumarin ring compared to vanillobiocin. antibiotic_resistance ARO:3004718 Declovanillobiocin Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. Declovanillobiocin lacks the chlorine atom at the aminocoumarin ring compared to vanillobiocin. PMID:15152806 A tetracyline resistance gene located on an approximately 300-kb plasmid, designated p47AB. It inactivates all tetracyclines, including tigecycline, eravacycline, and omadacycline.Adjacent to insertion sequence ISVsa3 on the conjugative plasmid. tet(X3) tetX3 antibiotic_resistance ARO:3004719 tet(X3) A tetracyline resistance gene located on an approximately 300-kb plasmid, designated p47AB. It inactivates all tetracyclines, including tigecycline, eravacycline, and omadacycline.Adjacent to insertion sequence ISVsa3 on the conjugative plasmid. PMID:31133751 tet(X3) A tetracyline resistance gene located on an approximately 180-kb plasmid, designated p47EC. It inactivates all tetracyclines, including tigecycline, eravacycline, and omadacycline.Adjacent to insertion sequence ISVsa3 on the conjugative plasmid. tet(X4) tetX4 antibiotic_resistance ARO:3004720 tet(X4) A tetracyline resistance gene located on an approximately 180-kb plasmid, designated p47EC. It inactivates all tetracyclines, including tigecycline, eravacycline, and omadacycline.Adjacent to insertion sequence ISVsa3 on the conjugative plasmid. PMID:31133751 tet(X4) RpsA, the 30S ribosomal protein S1 of Mycobacterium tuberculosis, is involved in trans-translation and is targeted by pyrazinonic acid, the active form of the antibiotic pyrazinamide, which disrupts the initiation of mRNA translation. Mutations in the amino acid sequence of rpsA can confer resistance to pyrazinamide maintaining rpsA function. Mtub_rpsA_PZA antibiotic_resistance ARO:3004721 Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide RpsA, the 30S ribosomal protein S1 of Mycobacterium tuberculosis, is involved in trans-translation and is targeted by pyrazinonic acid, the active form of the antibiotic pyrazinamide, which disrupts the initiation of mRNA translation. Mutations in the amino acid sequence of rpsA can confer resistance to pyrazinamide maintaining rpsA function. PMID:29921403 PMID:30402208 PMID:30858213 PMID:31097767 Mtub_rpsA_PZA The 30S ribosomal protein S1 of Mycobacterium tuberculosis is required for mRNA translation initiation, playing a particular role in trans-translation. Mutations to rpsA prevent pyrazinoic acid, the active form of pyrazinamide catalyzed by pncA, from targeting RpsA to inhibit translation. Ribosomal protein S1 antibiotic_resistance ARO:3004722 pyrazinamide resistant rpsA The 30S ribosomal protein S1 of Mycobacterium tuberculosis is required for mRNA translation initiation, playing a particular role in trans-translation. Mutations to rpsA prevent pyrazinoic acid, the active form of pyrazinamide catalyzed by pncA, from targeting RpsA to inhibit translation. PMID:21835980 PMID:29921403 A method to determine microbial susceptibility to antibiotics in which test bacteria is inoculated onto an agar plate that contains a concentration gradient of antibiotic. The minimum inhibitory concentration of antibiotic is assessed. antibiotic_resistance ARO:3004723 gradient plate method A method to determine microbial susceptibility to antibiotics in which test bacteria is inoculated onto an agar plate that contains a concentration gradient of antibiotic. The minimum inhibitory concentration of antibiotic is assessed. PMID:12999676 An antibiotic cocktail containing the cephalosporin antibiotic ceftolozane and the beta-lactamase inhibitor tazobactam. antibiotic_resistance ARO:3004724 ceftolozane-tazobactam Point mutations in rpoC, an RNA polymerase subunit, which confer resistance to vancomycin. antibiotic_resistance ARO:3004725 vancomycin-resistant beta prime subunit of RNA polymerase (rpoC) Cefpirome is a fourth generation cephalosporin with activity against methicillin-susceptible Staphylococcus aureus, coagulase-negative staphylococci and viridans group streptococci, and in vitro activity towards Streptococcus pneumoniae. pubchem.compound:5479539 antibiotic_resistance ARO:3004726 cefpirome Cefpirome is a fourth generation cephalosporin with activity against methicillin-susceptible Staphylococcus aureus, coagulase-negative staphylococci and viridans group streptococci, and in vitro activity towards Streptococcus pneumoniae. PMID:9211085 Cefsulodin is a third generation cephalosporin with with activity against Pseudomonas spp., but little activity against other Gram-negative bacteria. pubchem.compound:5284530 antibiotic_resistance ARO:3004727 cefsulodin Cefsulodin is a third generation cephalosporin with with activity against Pseudomonas spp., but little activity against other Gram-negative bacteria. PMID:119787 Carumonam is a monobactam antibiotic. It has activity towards Gram-negative bacteria with negligible activity towards Gram-postitive bacteria. pubchem.compound:6540466 antibiotic_resistance ARO:3004728 carumonam Carumonam is a monobactam antibiotic. It has activity towards Gram-negative bacteria with negligible activity towards Gram-postitive bacteria. PMID:4073864 A monobactam with potent activity against Enterobacteriaceae. Stable to metallo-B-lactamases and serine carbapenemases resulting in potency against the majority of extended-spectrum B-lactamase-producing and carbapenem-resistant Enterobacteriaceae strains tested. pubchem.compound:118380292 antibiotic_resistance ARO:3004729 LYS228 A monobactam with potent activity against Enterobacteriaceae. Stable to metallo-B-lactamases and serine carbapenemases resulting in potency against the majority of extended-spectrum B-lactamase-producing and carbapenem-resistant Enterobacteriaceae strains tested. PMID:30038040 A pleuromutilin resistance gene encoding a predicted ABC-F transporter. The presence of inhibitory or sub-inhibitory concentrations of tiamulin showed that tva(A) confers reduced pleuromutilin susceptibility that does not lead to clinical resistance but facilitates the development of higher-level resistance via mutations in genes encoding ribosome-associated functions. tva(A) antibiotic_resistance ARO:3004730 tva(A) A pleuromutilin resistance gene encoding a predicted ABC-F transporter. The presence of inhibitory or sub-inhibitory concentrations of tiamulin showed that tva(A) confers reduced pleuromutilin susceptibility that does not lead to clinical resistance but facilitates the development of higher-level resistance via mutations in genes encoding ribosome-associated functions. PMID:29971045 tva(A) A fluoroquinolone with potent activity against Gram-positive pathogens. Showed the most potent in vitro and in vivo activities against drug-resistant Streptococcus pneumoniae. One of the most potent antibacterial agent against penicillin-resistant S. pneumoniae in a murine systemic infection model. pubchem.compound:54556623 antibiotic_resistance ARO:3004731 Zabofloxacin A fluoroquinolone with potent activity against Gram-positive pathogens. Showed the most potent in vitro and in vivo activities against drug-resistant Streptococcus pneumoniae. One of the most potent antibacterial agent against penicillin-resistant S. pneumoniae in a murine systemic infection model. PMID:16873394 PMID:27869677 An 8-cyano-substituted fluoroquinolone with increased antibacterial activity in acidic conditions in contrast to other fluoroquinolones which demonstrate reduced activity in lower pH. Finafloxacin showed increased bactericidal activity at pH 5 in comparison to pH 7 and ciprofloxacin at pH 5 in vitro. pubchem.compound:11567473 antibiotic_resistance ARO:3004732 Finafloxacin An 8-cyano-substituted fluoroquinolone with increased antibacterial activity in acidic conditions in contrast to other fluoroquinolones which demonstrate reduced activity in lower pH. Finafloxacin showed increased bactericidal activity at pH 5 in comparison to pH 7 and ciprofloxacin at pH 5 in vitro. PMID:21596526 PMID:28438936 A C-8-methoxy non-fluorinated quinolone exhibiting potent antibacterial activities against Gram-positive, including MRSA and fluoroquinolone-resistant MRSA, Gram-negative, and atypical pathogens, especially methicillin-resistant Staphylococcus aureus. pubchem.compound:11993740 antibiotic_resistance ARO:3004733 Nemonoxacin A C-8-methoxy non-fluorinated quinolone exhibiting potent antibacterial activities against Gram-positive, including MRSA and fluoroquinolone-resistant MRSA, Gram-negative, and atypical pathogens, especially methicillin-resistant Staphylococcus aureus. PMID:22650326 PMID:25529577 ARL-1 is a beta-lactamase gene found in Staphylococcus Arlettae. ARL-1 antibiotic_resistance ARO:3004734 ARL-1 ARL-1 is a beta-lactamase gene found in Staphylococcus Arlettae. PMID:28497118 ARL-1 ARL-2 is a beta-lactamase gene found in Staphylococcus Arlettae. ARL-2 antibiotic_resistance ARO:3004735 ARL-2 ARL-2 is a beta-lactamase gene found in Staphylococcus Arlettae. PMID:28497118 ARL-2 ARL-3 is a beta-lactamase gene found in Staphylococcus arlettae. ARL-3 antibiotic_resistance ARO:3004736 ARL-3 ARL-3 is a beta-lactamase gene found in Staphylococcus arlettae. PMID:28497118 ARL-3 ARL-4 is a beta-lactamase gene found in Staphylococcus arlettae. ARL-4 antibiotic_resistance ARO:3004737 ARL-4 ARL-4 is a beta-lactamase gene found in Staphylococcus arlettae. PMID:28497118 ARL-4 ARL-5 is a beta-lactamase gene found in Staphylococcus arlettae. ARL-5 antibiotic_resistance ARO:3004738 ARL-5 ARL-5 is a beta-lactamase gene found in Staphylococcus arlettae. PMID:28497118 ARL-5 ARL-6 is a beta-lactamase gene found in Staphylococcus arlettae. ARL-6 antibiotic_resistance ARO:3004739 ARL-6 ARL-6 is a beta-lactamase gene found in Staphylococcus arlettae. PMID:28497118 ARL-6 AST-1 is a broad-spectrum beta-lactamase gene found in Nocardia asteroides. AST-1 antibiotic_resistance ARO:3004740 AST-1 AST-1 is a broad-spectrum beta-lactamase gene found in Nocardia asteroides. PMID:11181374 AST-1 A family of beta-lactamase known for their broad spectrum resistance profile. antibiotic_resistance ARO:3004741 AST Beta-lactamase A family of beta-lactamase known for their broad spectrum resistance profile. PMID:11181374 ARL beta-lactamase is an AMR Gene Family associated with Staphylococcus arlettae. antibiotic_resistance ARO:3004742 ARL Beta-lactamase ARL beta-lactamase is an AMR Gene Family associated with Staphylococcus arlettae. PMID:28497118 MIR-23, originally described as AZECL-25, is a class C beta-lactamase that is found in Enterobacter cloacae. AZECL-25 MIR-23 antibiotic_resistance ARO:3004745 MIR-23 MIR-23, originally described as AZECL-25, is a class C beta-lactamase that is found in Enterobacter cloacae. PMID:25022578 MIR-23 BAT is a class D beta-lactamase. antibiotic_resistance ARO:3004746 BAT Beta-lactamase BAT is a class D beta-lactamase. PMID:21464989 BAT-1 is a class D beta-lactamase found in Bacillus atrophaeus. BAT-1 antibiotic_resistance ARO:3004747 BAT-1 BAT-1 is a class D beta-lactamase found in Bacillus atrophaeus. PMID:21464989 PMID:22843588 BAT-1 BCL beta-lactamase is a class A beta-lactamase. antibiotic_resistance ARO:3004748 BCL Beta-lactamase BCL beta-lactamase is a class A beta-lactamase. PMID:12654668 PMID:17846134 BCL-1 is a class A beta-lactamase found in Alkalihalobacillus clausii. BCL-1 antibiotic_resistance ARO:3004749 BCL-1 BCL-1 is a class A beta-lactamase found in Alkalihalobacillus clausii. PMID:12654668 PMID:17846134 BCL-1 BES beta-lactamase is a class A beta-lactamase family. antibiotic_resistance ARO:3004750 BES Beta-lactamase BES beta-lactamase is a class A beta-lactamase family. PMID:11036023 BES-1 is a class A beta-lactamase that is found in Serratia marcescens. BES-1 antibiotic_resistance ARO:3004751 BES-1 BES-1 is a class A beta-lactamase that is found in Serratia marcescens. PMID:11036023 BES-1 BIC is a class A beta-lactamase conferring resistance to carbapenem. antibiotic_resistance ARO:3004752 BIC Beta-lactamase BIC is a class A beta-lactamase conferring resistance to carbapenem. PMID:19901091 BIC-1 is a beta-lactamase conferring resistance to carbapenems that is found in Pseudomonas fluorescens. BIC-1 antibiotic_resistance ARO:3004753 BIC-1 BIC-1 is a beta-lactamase conferring resistance to carbapenems that is found in Pseudomonas fluorescens. PMID:19901091 BIC-1 BIL beta-lactamase is plasmid-borne and is a class C beta-lactamase. antibiotic_resistance ARO:3004754 BIL Beta-lactamase BIL beta-lactamase is plasmid-borne and is a class C beta-lactamase. PMID:8067761 BIL-1 is a plasmid-borne beta-lactamase that is also a class C beta-lactamase. BIL-1 antibiotic_resistance ARO:3004755 BIL-1 BIL-1 is a plasmid-borne beta-lactamase that is also a class C beta-lactamase. PMID:8067761 BIL-1 BKC beta-lactamase is a class A beta-lactamase. antibiotic_resistance ARO:3004756 BKC Beta-lactamase BKC beta-lactamase is a class A beta-lactamase. PMID:26055384 BKC-1 is a beta-lactamase conferring resistance to carbapenem and is found in Brazilian Klebsiella. BKC-1 antibiotic_resistance ARO:3004757 BKC-1 BKC-1 is a beta-lactamase conferring resistance to carbapenem and is found in Brazilian Klebsiella. PMID:26055384 BKC-1 BPU is a class D beta lactamase gene family. antibiotic_resistance ARO:3004758 BPU Beta-lactamase BPU is a class D beta lactamase gene family. PMID:17895969 PMID:23799069 PMID:23812891 BPU-1 is a class D beta-lactamase found in Bacillus pumilus. BPU-1 antibiotic_resistance ARO:3004759 BPU-1 BPU-1 is a class D beta-lactamase found in Bacillus pumilus. PMID:17895969 PMID:23799069 PMID:23812891 PMID:27351589 PMID:29884123 BPU-1 BRO is a class A beta-lactamase that is found in M.catarrhalis. antibiotic_resistance ARO:3004760 BRO Beta-lactamase BRO is a class A beta-lactamase that is found in M.catarrhalis. PMID:8849261 BRO-1 is a class A beta-lactamase found in M.catarrhalis. BRO-1 antibiotic_resistance ARO:3004761 BRO-1 BRO-1 is a class A beta-lactamase found in M.catarrhalis. PMID:8849261 BRO-1 BRO-2 is a class A beta-lactamase found in M.catarrhalis. BRO-2 antibiotic_resistance ARO:3004762 BRO-2 BRO-2 is a class A beta-lactamase found in M.catarrhalis. PMID:8849261 BRO-2 CBP is a class A beta-lactamase family found in C. botulinum. antibiotic_resistance ARO:3004763 CBP beta-lactamase CBP-1 is a class A beta-lactamase gene found in C. botulinum. CBP-1 antibiotic_resistance ARO:3004764 CBP-1 CBP-1 CGA is a class A beta-lactamase family that is found in Chryseobacterium gleum. antibiotic_resistance ARO:3004765 CGA beta-lactamase CGA is a class A beta-lactamase family that is found in Chryseobacterium gleum. PMID:11897576 CGA-1 is a class A beta-lactamase gene found in Chryseobacterium gleum. CGA-1 antibiotic_resistance ARO:3004766 CGA-1 CGA-1 is a class A beta-lactamase gene found in Chryseobacterium gleum. PMID:11897576 CGA-1 CIA is a class A beta-lactamase gene family found in Chryseobacterium indologenes. antibiotic_resistance ARO:3004767 CIA beta-lactamase CIA is a class A beta-lactamase gene family found in Chryseobacterium indologenes. PMID:22083470 CIA-1 is a class A beta-lactamase gene found in Chryseobacterium indologenes. CIA-1 antibiotic_resistance ARO:3004768 CIA-1 CIA-1 is a class A beta-lactamase gene found in Chryseobacterium indologenes. PMID:22083470 CIA-1 CIA-2 is a class A beta-lactamase gene found in Chryseobacterium indologenes. CIA-2 antibiotic_resistance ARO:3004769 CIA-2 CIA-2 is a class A beta-lactamase gene found in Chryseobacterium indologenes. PMID:22083470 CIA-2 CIA-3 is a class A beta-lactamase gene found in Chryseobacterium indologenes. CIA-3 antibiotic_resistance ARO:3004770 CIA-3 CIA-3 is a class A beta-lactamase gene found in Chryseobacterium indologenes. PMID:22083470 CIA-3 CIA-4 is a class A beta-lactamase gene found in Chryseobacterium indologenes. CIA-4 antibiotic_resistance ARO:3004771 CIA-4 CIA-4 is a class A beta-lactamase gene found in Chryseobacterium indologenes. PMID:22083470 CIA-4 CKO is a class A beta-lactamase gene family found in Citrobacter koseri. antibiotic_resistance ARO:3004772 CKO beta-lactamase CKO is a class A beta-lactamase gene family found in Citrobacter koseri. PMID:16445758 CKO-1 is a class A beta-lactamase gene found in Citrobacter koseri. CKO-1 antibiotic_resistance ARO:3004773 CKO-1 CKO-1 is a class A beta-lactamase gene found in Citrobacter koseri. PMID:16445758 CKO-1 CME is a class A beta-lactamase gene family belonging to Chryseobacterium meningosepticum. antibiotic_resistance ARO:3004774 CME beta-lactamase CME is a class A beta-lactamase gene family belonging to Chryseobacterium meningosepticum. PMID:10471563 CME-1 is a class A beta-lactamase gene belonging to Chryseobacterium meningosepticum. CME-1 antibiotic_resistance ARO:3004775 CME-1 CME-1 is a class A beta-lactamase gene belonging to Chryseobacterium meningosepticum. PMID:10471563 CME-1 CMH is a class C beta-lactamase gene family belonging to Enterobacter cloacae. antibiotic_resistance ARO:3004776 CMH beta-lactamase CMH-1 is a class C beta-lactamase gene found in Enterobacter cloacae. CMH-1 antibiotic_resistance ARO:3004777 CMH-1 CMH-1 CMY-135 is a class C beta-lactamase that confers resistance to cephamycin. CMY-135 antibiotic_resistance ARO:3004778 CMY-135 CMY-135 is a class C beta-lactamase that confers resistance to cephamycin. PMID:26126492 CMY-135 DES is a class A beta-lactamase gene family found in Desulfovibrio desulfuricans. antibiotic_resistance ARO:3004779 DES beta-lactamase DES is a class A beta-lactamase gene family found in Desulfovibrio desulfuricans. PMID:12234847 DES-1 is a class A beta-lactamase gene found in Desulfovibrio desulfuricans. DES-1 antibiotic_resistance ARO:3004780 DES-1 DES-1 is a class A beta-lactamase gene found in Desulfovibrio desulfuricans. PMID:12234847 DES-1 ERP is a class A beta-lactamase gene family found in Erwinia persicina. antibiotic_resistance ARO:3004781 ERP beta-lactamase ERP is a class A beta-lactamase gene family found in Erwinia persicina. PMID:12384342 ERP-1 is a class A beta-lactamase gene found in Erwinia persicina. ERP-1 antibiotic_resistance ARO:3004782 ERP-1 ERP-1 is a class A beta-lactamase gene found in Erwinia persicina. PMID:12384342 ERP-1 FAR is a class A extended spectrum beta-lactamase gene family found in Nocardia farcinica. antibiotic_resistance ARO:3004783 FAR beta-lactamase FAR-1 is a class A beta-lactamase gene found in Nocardia farcinica. FAR-1 antibiotic_resistance ARO:3004784 FAR-1 FAR-1 FIM is a metallo-beta-lactamase gene family found in Pseudomonas aeruginosa. antibiotic_resistance ARO:3004785 FIM beta-lactamase FIM is a metallo-beta-lactamase gene family found in Pseudomonas aeruginosa. PMID:23114762 FIM-1 is a metallo-beta-lactamase gene found in Pseudomonas aeruginosa from isolates in Italy. FIM-1 antibiotic_resistance ARO:3004786 FIM-1 FIM-1 is a metallo-beta-lactamase gene found in Pseudomonas aeruginosa from isolates in Italy. PMID:23114762 FIM-1 FONA is a class A beta-lactamase gene family found in Serratia fonticola. antibiotic_resistance ARO:3004787 FONA beta-lactamase FONA-1 is a class A beta-lactamase gene found in Serratia fonticola. FONA-1 antibiotic_resistance ARO:3004788 FONA-1 FONA-1 FONA-2 is a class A beta-lactamase gene found in Serratia fonticola. FONA-2 antibiotic_resistance ARO:3004789 FONA-2 FONA-2 FONA-3 is a class A beta-lactamase gene found in Serratia fonticola. FONA-3 antibiotic_resistance ARO:3004790 FONA-3 FONA-3 FONA-4 is a class A beta-lactamase gene found in Serratia fonticola. FONA-4 antibiotic_resistance ARO:3004791 FONA-4 FONA-4 FONA-5 is a class A beta-lactamase gene found in Serratia fonticola. FONA-5 antibiotic_resistance ARO:3004792 FONA-5 FONA-5 FONA-6 is a class A beta-lactamase gene found in Serratia fonticola. FONA-6 antibiotic_resistance ARO:3004793 FONA-6 FONA-6 FPH is a carbapenem-hydrolyzing class A beta-lactamase found in Francisella philomiragia. antibiotic_resistance ARO:3004794 FPH beta-lactamase FPH is a carbapenem-hydrolyzing class A beta-lactamase found in Francisella philomiragia. PMID:25931589 FPH-1 is a carbapenem-hydrolyzing class A beta-lactamase gene found in Francisella philomiragia. FPH-1 antibiotic_resistance ARO:3004795 FPH-1 FPH-1 is a carbapenem-hydrolyzing class A beta-lactamase gene found in Francisella philomiragia. PMID:25931589 FPH-1 FRI is a carbapenem-Hydrolyzing Class A beta-Lactamase from Enterobacter cloacae. antibiotic_resistance ARO:3004796 FRI beta-lactamase FRI is a carbapenem-Hydrolyzing Class A beta-Lactamase from Enterobacter cloacae. PMID:26392482 FRI-1 is a carbapenem-hydrolyzing Class A beta-lactamase found in Enterobacter cloacae. FRI-1 antibiotic_resistance ARO:3004797 FRI-1 FRI-1 is a carbapenem-hydrolyzing Class A beta-lactamase found in Enterobacter cloacae. PMID:26392482 FRI-1 FRI-2 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae. FRI-2 antibiotic_resistance ARO:3004798 FRI-2 FRI-2 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae. PMID:30060114 FRI-2 FRI-3 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter cloacae. FRI-3 antibiotic_resistance ARO:3004799 FRI-3 FRI-3 FTU is a class A beta-lactamase gene family found in Francisella tularensis. antibiotic_resistance ARO:3004800 FTU beta-lactamase FTU is a class A beta-lactamase gene family found in Francisella tularensis. PMID:15640799 FTU-1 is a class A beta-lactamase gene found in Francisella tularensis. It causes Tularemia. FTU-1 antibiotic_resistance ARO:3004801 FTU-1 FTU-1 is a class A beta-lactamase gene found in Francisella tularensis. It causes Tularemia. PMID:15640799 PMID:20140244 FTU-1 GOB-10 is a class B beta-lactamase gene found in Chryseobacterium meningosepticum. GOB-10 antibiotic_resistance ARO:3004802 GOB-10 GOB-10 is a class B beta-lactamase gene found in Chryseobacterium meningosepticum. PMID:20571954 GOB-10 GOB-11 is a class B beta-lactamase gene found in Chryseobacterium meningosepticum. GOB-11 antibiotic_resistance ARO:3004803 GOB-11 GOB-11 is a class B beta-lactamase gene found in Chryseobacterium meningosepticum. PMID:20571954 GOB-11 GOB-12 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-12 antibiotic_resistance ARO:3004804 GOB-12 GOB-12 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:20571954 GOB-12 GOB-13 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-13 antibiotic_resistance ARO:3004805 GOB-13 GOB-13 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:20571954 GOB-13 GOB-14 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-14 antibiotic_resistance ARO:3004806 GOB-14 GOB-14 GOB-15 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-15 antibiotic_resistance ARO:3004807 GOB-15 GOB-15 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:20571954 GOB-15 GOB-16 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-16 antibiotic_resistance ARO:3004808 GOB-16 GOB-16 GOB-2 is class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-2 antibiotic_resistance ARO:3004809 GOB-2 GOB-2 is class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:10858348 GOB-2 GOB-3 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-3 antibiotic_resistance ARO:3004810 GOB-3 GOB-3 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:10858348 GOB-3 GOB-4 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-4 antibiotic_resistance ARO:3004811 GOB-4 GOB-4 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:10858348 GOB-4 GOB-5 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-5 antibiotic_resistance ARO:3004812 GOB-5 GOB-5 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:10858348 GOB-5 GOB-6 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-6 antibiotic_resistance ARO:3004813 GOB-6 GOB-6 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:10858348 GOB-6 GOB-7 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-7 antibiotic_resistance ARO:3004814 GOB-7 GOB-7 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:10858348 GOB-7 GOB-8 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-8 antibiotic_resistance ARO:3004815 GOB-8 GOB-8 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:20571954 GOB-8 GOB-9 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-9 antibiotic_resistance ARO:3004816 GOB-9 GOB-9 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:20571954 GOB-9 HERA-2 is a class A beta-lactamase found in Atlantibacter hermannii. HERA-2 antibiotic_resistance ARO:3004817 HERA-2 HERA-2 is a class A beta-lactamase found in Atlantibacter hermannii. PMID:12878539 HERA-2 HERA-3 is a class A beta-lactamase found in Escherichia hermannii. HERA-3 antibiotic_resistance ARO:3004818 HERA-3 HERA-3 is a class A beta-lactamase found in Escherichia hermannii. PMID:12878539 HERA-3 HERA-4 is a class A beta-lactamase found in Escherichia hermannii. HERA-4 antibiotic_resistance ARO:3004819 HERA-4 HERA-4 is a class A beta-lactamase found in Escherichia hermannii. PMID:12878539 HERA-4 HERA-5 is a class A beta-lactamase found in Escherichia hermannii. HERA-5 antibiotic_resistance ARO:3004820 HERA-5 HERA-5 is a class A beta-lactamase found in Escherichia hermannii. PMID:12878539 HERA-5 HERA-6 is a class A beta-lactamase found in Escherichia hermannii. HERA-6 antibiotic_resistance ARO:3004821 HERA-6 HERA-6 is a class A beta-lactamase found in Escherichia hermannii. PMID:12878539 HERA-6 HERA-8 is a class A beta-lactamase found in Escherichia hermannii. HERA-8 antibiotic_resistance ARO:3004822 HERA-8 HERA-8 is a class A beta-lactamase found in Escherichia hermannii. PMID:12878539 HERA-8 IMP-52 is a class B metallo-beta-lactamase found in Escherichia coli. IMP-52 antibiotic_resistance ARO:3004823 IMP-52 IMP-52 LAP is a Ambler Class A beta-lactamase gene family that confers resistance to beta-lactams. antibiotic_resistance ARO:3004824 LAP beta-lactamase LAP is a Ambler Class A beta-lactamase gene family that confers resistance to beta-lactams. PMID:16982792 PMID:17116662 LAP-1 is an Ambler Class A beta-lactamase gene. LAP-1 antibiotic_resistance ARO:3004825 LAP-1 LAP-1 is an Ambler Class A beta-lactamase gene. PMID:16982792 PMID:17116662 LAP-1 LAP-2 is an Ambler Class A beta-lactamase gene. LAP-2 antibiotic_resistance ARO:3004826 LAP-2 LAP-2 is an Ambler Class A beta-lactamase gene. PMID:18550213 LAP-2 LEN-35 is a Class A beta-lactamase gene found in Klebsiella variicola. LEN-35 antibiotic_resistance ARO:3004827 LEN-35 LEN-35 LEN-36 is a class A beta-lactamase gene found in Klebsiella variicola. LEN-36 antibiotic_resistance ARO:3004828 LEN-36 LEN-36 LEN-37 is a Class A beta-lactamase gene found in Klebsiella variicola. LEN-37 antibiotic_resistance ARO:3004829 LEN-37 LEN-37 PBP2 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the penA gene, due to mutations can cause resistance to various drugs such as Penicillin and Ceftriaxone. Ngon_PBP2_BLA penA antibiotic_resistance ARO:3004832 Neisseria gonorrhoeae PBP2 conferring resistance to beta-lactam antibiotics PBP2 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the penA gene, due to mutations can cause resistance to various drugs such as Penicillin and Ceftriaxone. PMID:20511367 PMID:22155830 PMID:23587946 PMID:25403720 PMID:25845238 PMID:34013864 Ngon_PBP2_BLA Point mutation in Neisseria gonorrhoea PBP1 (ponA) decreases affinity between beta-lactam antibiotic molecule and PBP1, thereby conferring resistance to beta-lactam antibiotics. Ngon_PBP1_BLA ponA antibiotic_resistance ARO:3004833 Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam antibiotics Point mutation in Neisseria gonorrhoea PBP1 (ponA) decreases affinity between beta-lactam antibiotic molecule and PBP1, thereby conferring resistance to beta-lactam antibiotics. PMID:11850260 Ngon_PBP1_BLA PilQ is an important gonococcal outer membrane component, member of secretin protein family, and involved in Type IV pilus formation. Ngon_pilQ_BLA penC mutation antibiotic_resistance ARO:3004835 Neisseria gonorrhoeae pilQ gene conferring resistance to beta-lactam PilQ is an important gonococcal outer membrane component, member of secretin protein family, and involved in Type IV pilus formation. PMID:16101998 Ngon_pilQ_BLA Point mutation in the 23S rRNA of Neisseria gonorrhoea shown to confer resistance to azithromycin, a macrolide type antibiotic. Ngon_23S_AZM antibiotic_resistance ARO:3004836 Neisseria gonorrhoeae 23S rRNA with mutation conferring resistance to azithromycin Point mutation in the 23S rRNA of Neisseria gonorrhoea shown to confer resistance to azithromycin, a macrolide type antibiotic. PMID:10508026 PMID:20585125 PMID:25394255 PMID:26601852 PMID:30917979 PMID:34013864 Ngon_23S_AZM An OXA-12-family class D beta-lactamase identified from Aeromonas hydrophila. Aeromonas ampH OXA-724 antibiotic_resistance ARO:3004837 OXA-724 An OXA-12-family class D beta-lactamase identified from Aeromonas hydrophila. PMID:11062187 OXA-724 A class-A beta-lactamase from Klebsiella pneumoniae. LEN-30 antibiotic_resistance ARO:3004838 LEN-30 LEN-30 A class-A beta-lactamase from Klebsiella variicola. LEN-32 antibiotic_resistance ARO:3004839 LEN-32 LEN-32 A class-A beta-lactamase from Klebsiella variicola. LEN-34 antibiotic_resistance ARO:3004840 LEN-34 LEN-34 A class-A beta-lactamase from Klebsiella. LEN-38 antibiotic_resistance ARO:3004841 LEN-38 LEN-38 A class-A broad-spectrum beta-lactamase identified from Klebsiella sp. LEN-39 antibiotic_resistance ARO:3004842 LEN-39 LEN-39 A class-A broad-spectrum beta-lactamase identified from Klebsiella sp. LEN-40 antibiotic_resistance ARO:3004843 LEN-40 LEN-40 A class-A broad-spectrum beta-lactamase identified from Klebsiella. LEN-41 antibiotic_resistance ARO:3004844 LEN-41 LEN-41 A class-A broad-spectrum beta-lactamase from Klebsiella. LEN-42 antibiotic_resistance ARO:3004845 LEN-42 LEN-42 A class-A broad-spectrum beta-lactamase from Klebsiella. LEN-43 antibiotic_resistance ARO:3004846 LEN-43 LEN-43 A class-A broad-spectrum beta-lactamase from Klebsiella. LEN-51 antibiotic_resistance ARO:3004847 LEN-51 LEN-51 A class-A broad-spectrum beta-lactamase from Klebsiella. LEN-55 antibiotic_resistance ARO:3004848 LEN-55 LEN-55 A class-A broad-spectrum beta-lactamase from Klebsiella. LEN-58 antibiotic_resistance ARO:3004849 LEN-58 LEN-58 MtrR is a repressor of mtrCDE efflux pump expression, point mutations in mtrR confer resistance to azithromycin and other drugs. Ngon_mtrR_AZM antibiotic_resistance ARO:3004851 Neisseria gonorrhoeae mtrR with mutation conferring resistance MtrR is a repressor of mtrCDE efflux pump expression, point mutations in mtrR confer resistance to azithromycin and other drugs. PMID:10508026 PMID:18761689 Ngon_mtrR_AZM An experimental serine beta-lactamase inhibitor comparable to clavulanic acid, tazobactam and sulbactam. pubchem.compound:23676494 antibiotic_resistance ARO:3004852 SYN-1012 Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to capreomycin. Mtub_16S_CAP antibiotic_resistance ARO:3004853 Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to capreomycin Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to capreomycin. PMID:24953243 Mtub_16S_CAP A CMY-2-like beta-lactamase which confers resistance to cephalosporin antibiotics, and is also capable of hydrolyzing the CMY-2 inhibitors ticarcillin and cloxacillin. CMY-136 antibiotic_resistance ARO:3004854 CMY-136 A CMY-2-like beta-lactamase which confers resistance to cephalosporin antibiotics, and is also capable of hydrolyzing the CMY-2 inhibitors ticarcillin and cloxacillin. PMID:30788955 CMY-136 SCOs are Class A beta-lactamases that confer resistance to a narrow range of penams, with some minor activity on cephalosporins and carbapenems. antibiotic_resistance ARO:3004855 SCO beta-lactamase SCOs are Class A beta-lactamases that confer resistance to a narrow range of penams, with some minor activity on cephalosporins and carbapenems. PMID:17353248 PMID:17420213 PMID:20956594 Narrow-spectrum beta-lactamase isolated from several Acinetobacter spp. isolates from Argentina, as well as E. Coli. Hydrolyzes penicillins at a high level and cephalosporins and carbapenems at a very low level. A1E3K9 SCO-1 blaSCO-1 antibiotic_resistance ARO:3004856 SCO-1 Narrow-spectrum beta-lactamase isolated from several Acinetobacter spp. isolates from Argentina, as well as E. Coli. Hydrolyzes penicillins at a high level and cephalosporins and carbapenems at a very low level. PMID:17353248 PMID:17420213 PMID:20956594 SCO-1 Experimental antibiotic in phase two trial for Neisseria gonorrhoeae treatment. pubchem.compound:76685216 antibiotic_resistance ARO:3004858 Zoliflodacin Experimental antibiotic in phase two trial for Neisseria gonorrhoeae treatment. PMID:31730160 Point mutation in Neisseria gonorrhoea gyrase B decreases affinity to zoliflodacin antibiotic. Ngon_gyrB_ZOL antibiotic_resistance ARO:3004859 Neisseria gonorrhoeae gyrB conferring resistance to zoliflodacin Point mutation in Neisseria gonorrhoea gyrase B decreases affinity to zoliflodacin antibiotic. PMID:31730160 Ngon_gyrB_ZOL Point mutations in Burkholderia gyrA that confer resistance to ciprofloxacin, a fluoroquinolone antibiotic. Bdol_gyrA_FLO antibiotic_resistance ARO:3004860 Burkholderia dolosa gyrA conferring resistance to fluoroquinolones Point mutations in Burkholderia gyrA that confer resistance to ciprofloxacin, a fluoroquinolone antibiotic. PMID:25153194 PMID:25931592 Bdol_gyrA_FLO A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-18 antibiotic_resistance ARO:3004861 NDM-18 NDM-18 A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-19 antibiotic_resistance ARO:3004862 NDM-19 NDM-19 A class B New Delhi metallo-beta-lactamase. NDM-20 antibiotic_resistance ARO:3004863 NDM-20 NDM-20 A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-21 antibiotic_resistance ARO:3004864 NDM-21 NDM-21 A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-22 antibiotic_resistance ARO:3004865 NDM-22 NDM-22 A class B New Delhi metallo-beta-lactamase. NDM-23 antibiotic_resistance ARO:3004866 NDM-23 NDM-23 A class B New Delhi metallo-beta-lactamase. NDM-24 antibiotic_resistance ARO:3004867 NDM-24 NDM-24 A class B New Delhi metallo-beta-lactamase. NDM-25 antibiotic_resistance ARO:3004868 NDM-25 NDM-25 A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-26 antibiotic_resistance ARO:3004869 NDM-26 NDM-26 A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-27 antibiotic_resistance ARO:3004870 NDM-27 NDM-27 A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-28 antibiotic_resistance ARO:3004871 NDM-28 NDM-28 Point mutations in Neisseria gonorrhoeae dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. Ngon_folP_SLF antibiotic_resistance ARO:3004873 Neisseria gonorrhoeae folP with mutation conferring resistance to sulfonamides Point mutations in Neisseria gonorrhoeae dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. PMID:31358980 Ngon_folP_SLF Genes with mutations in inhA which confer resistance to isoniazid class antibiotics. antibiotic_resistance ARO:3004874 isoniazid resistant inhA Genes with mutations in inhA which confer resistance to ethionamide class antibiotics. antibiotic_resistance ARO:3004875 inhA with mutations with conferring resistance to ethionamide inhA is a enoyl-acyl carrier reductase used in lipid metabolism and farry acid biosynthesis. It is inhibited by ethionamide. Mutations in the promoter region or multiple copies of the inhA show marked resistance to ethionamide mediated inhibition of mycolic acid biosynthesis. Mtub_inhA_ETO antibiotic_resistance ARO:3004876 Mycobacterium tuberculosis inhA mutations conferring resistance to ethionamide inhA is a enoyl-acyl carrier reductase used in lipid metabolism and farry acid biosynthesis. It is inhibited by ethionamide. Mutations in the promoter region or multiple copies of the inhA show marked resistance to ethionamide mediated inhibition of mycolic acid biosynthesis. PMID:14623976 PMID:19581462 PMID:25568071 Mtub_inhA_ETO Mutations that occur in the clp protease subunit clpC1 that increases resistance to antibiotics. antibiotic_resistance ARO:3004877 antibiotic resistant clpC1 clpC1 is a subunit of the clp protease that is ATP-dependent. It functions to direct the clp protease to specific substrates. In the presence of ATP it hydrolyses proteins and may be involved in the degradation of denatured proteins. antibiotic_resistance ARO:3004878 pyrazinamide resistant clpC1 Mutations that occur in gpsI that increases resistance to antibiotics. antibiotic_resistance ARO:3004879 antibiotic resistant gpsI gpsI codes for polyribonucleotide nucleotidyltransferase which is a protein involved in mRNA degradation. It catalyzes the phosphorolysis of single-stranded polyribonucleotides in the 3'- to 5'-direction. antibiotic_resistance ARO:3004880 pyrazinamide resistant gpsI Mutations that occur in the mas that increases resistance to antibiotics. antibiotic_resistance ARO:3004881 antibiotic resistant mas Mas is a multifunctional mycocerosic acid synthase membrane-associated mas. It catalyzes the elongation of N-fatty acyl-CoA with methylamalonyl-CoA as the elongating agent to form mycocerosyl fatty acids present in mycobacterium. antibiotic_resistance ARO:3004882 pyrazinamide resistant mas Mutations that occur in the ppsC that increases resistance to antibiotics. antibiotic_resistance ARO:3004883 antibiotic resistant ppsC ppsC codes for the phthiocerol synthesis polyketide synthase type 1. It is involved in the elongation of C22-24 fatty acids by the addition of methylmalonyl-CoA extender units to yield phthiocerol derivatives in a complete reduction. Research has pointed towards this protein to be a high confidence drug target. antibiotic_resistance ARO:3004884 pyrazinamide resistant ppsC Mutations that occur in the ppsD that increases resistance to antibiotics. antibiotic_resistance ARO:3004885 antibiotic resistant ppsD ppsD codes for the phthiocerol synthesis polyketide synthase type 1. It is involved in the elongation of C22-24 fatty acids by the addition of malonyl-CoA extender units to yield phthiocerol derivatives in a partial reduction. antibiotic_resistance ARO:3004886 pyrazinamide resistant ppsD Mutations that occur in the fabg1 gene resulting in the inability for the antibiotic to inhibit mycolic acid biosynthesis. antibiotic_resistance ARO:3004887 antibiotic resistant fabG1 fabG1 is involved in the fatty acid synthesis pathway, acting in the first reduction step for mycolic acid. It is associated with ethionamide resistance. antibiotic_resistance ARO:3004888 Ethionamide resistant fabG1 Mutations that occur on the mshC gene resulting in the inability for antibiotic to function. antibiotic_resistance ARO:3004889 antibiotic resistant mshC Mutations that occur in mshC which is involved in the third step of mycothiol biosynthesis. It catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins. The gene exhibits resistance to ethionamide. antibiotic_resistance ARO:3004890 ethionamide resistant mshC Mutations that occur on the nudC gene resulting in the inability for antibiotic to function. antibiotic_resistance ARO:3004891 antibiotic resistant nudC nudC is a NADH pyrophosphatase that is involved in nicotinate and nicotinamide metabolism. Mutations that occur on the nudC gene resulting in the inability for ethionamide to function. antibiotic_resistance ARO:3004892 ethionamide resistant nudC Mutations in ahpC that contribute to antibiotic resistance by preventing ahpC from activating antibiotics. antibiotic_resistance ARO:3004893 antibiotic resistant ahpC An alkyl hydroperoxide reductase that catalyzes the reduction of organic hydrogen peroxide to water and organic alcohols. Plays a role in protecting oxidative stress. antibiotic_resistance ARO:3004894 Isoniazid resistant ahpC fabG1 is involved in the fatty acid synthesis pathway, acting in the first reduction step for mycolic acid. It is associated with isoniazid resistance. antibiotic_resistance ARO:3004895 isoniazid resistant fabG1 Mutations that occur in furA which is in the regulatory region of katG. Mutations within the gene contribute to antibiotic resistance. antibiotic_resistance ARO:3004896 antibiotic resistant furA Transcriptional regulator furA, represses the transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region. antibiotic_resistance ARO:3004897 isoniazid resistant furA Mutations in inbR that contribute to antibiotic resistance by preventing antibiotic activation. antibiotic_resistance ARO:3004898 antibiotic resistant inbR inbR is part of the transcriptional factor family TetR. It acts as a repressor to regulate efflux pumps involved in antibiotic resistance. Rv0275c antibiotic_resistance ARO:3004899 isoniazid resistant inbR Mutations that occur in the mshA gene resulting in the inability for antibiotic to activate. antibiotic_resistance ARO:3004900 antibiotic resistant mshA mshA is a glycosyltransferase and is involved in the first step of mycothiol biosynthesis. This is a step that is required for growth in mycobacterium tuberculosis. Resistance has been shown in the gene to isoniazid. antibiotic_resistance ARO:3004901 isoniazid resistant mshA Mutations that occur in the mshB gene that results in antibiotic resistance. antibiotic_resistance ARO:3004902 antibiotic resistant mshB mshB is a deacetylase that is involved in the second step of mycothiol synthesis. GlcNAc-Ins is deacetylated by MshB to produce GlcN-Ins. antibiotic_resistance ARO:3004903 isoniazid resistant mshB Mutations that occur on the mshC gene resulting in the inability for isoniazid to function. It catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins. antibiotic_resistance ARO:3004904 isoniazid resistant mshC Mutations that occur within the coding region of mymA that prevent effective antibiotic function. antibiotic_resistance ARO:3004905 antibiotic resistant mymA mymA is an operon that begins at Rv3083 and ends at Rv3089 and is required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. It has shown to be resistant to isoniazid. antibiotic_resistance ARO:3004906 isoniazid resistant mymA Mutations that occur in mmaA3 which decreases effective functioning of antibiotics. antibiotic_resistance ARO:3004907 antibiotic resistant mmaA3 Methoxy mycolic acid synthase 3 is involved in the modification of mycolic acids. It represents a major part of the mycobacterial cell wall complex. antibiotic_resistance ARO:3004908 isoniazid resistant mmaA3 Mutations that occur in nat inactivate antibiotic functioning and contribute to antibiotic resistance. antibiotic_resistance ARO:3004909 Antibiotic resistant nat Arylamine N-acetyltransferase catalyzes the transfer of the acetyl group from acetyl coenzyme A to the free amino group of arylamines and hydrazines. Reports have shown that overexpression of this enzyme may be responsible for increased resistance to isoniazid. antibiotic_resistance ARO:3004910 isoniazid resistant nat nudC is a NADH pyrophosphatase that is involved in nicotinate and nicotinamide metabolism. Mutations that occur on the nudC gene resulting in the inability for isoniazid to function. antibiotic_resistance ARO:3004911 isoniazid resistant nudC Mutations that occur in SigI sigma factor that increase resistance to antibiotics. antibiotic_resistance ARO:3004912 antibiotic resistant sigI A sigma factor that acts as an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. Transcriptional analyses indicate that katG is also regulated by the sigma factor sigl and indicate resistance to isoniaizd. antibiotic_resistance ARO:3004913 isoniazid resistant sigI ESX-5 secretion system is are important for virulence of mycobacteria and is required for mycobacterial cell wall stability and host cell lysis. The system is comprised of genes that encode the structural components of the secretion system. The system secrets mycobacterial proteins involved in virulence and pathogenicity and important for mycobacterium viability. Resistance has been shown to specific antibiotics. antibiotic_resistance ARO:3004915 fluoroquinolone-resistant ESX5 secretion system Subunits of the secretion system complex that secretes proteins that contribute to resistance. antibiotic_resistance ARO:3004916 subunits of secretion system conferring antibiotic resistance Mutations in the eccB5 gene contributing to antibiotic resistance to fluoroquinolone. antibiotic_resistance ARO:3004917 fluoroquinolone resistant eccB5 eccB5 is a transmembrane protein within the ESX-5 secretion system complex. The complex is critical for mycobacterium viability and virulence in the host cell and mutations contribute to a decreased uptake of antibiotic in the outer membrane. Mtub_eccB5_FLO antibiotic_resistance ARO:3004918 Mycobacterium tuberculosis eccB5 conferring resistance to fluoroquinolones eccB5 is a transmembrane protein within the ESX-5 secretion system complex. The complex is critical for mycobacterium viability and virulence in the host cell and mutations contribute to a decreased uptake of antibiotic in the outer membrane. PMID:34161790 Mtub_eccB5_FLO eccC5 is a membrane-bound ATPase within the ESX-5 secretion system complex. The complex is critical for mycobacterium viability and virulence in the host cell and mutations contribute to a decreased uptake of antibiotic in the outer membrane, yet the Relational Sequencing Tuberculosis Data platform (ReSeqTB, https://platform.reseqtb.org) finds no evidence of an association between eccC5 mutations and drug resistance. Mtub_eccC5_FLO antibiotic_resistance ARO:3004919 Mycobacterium tuberculosis eccC5 conferring resistance to fluoroquinolones eccC5 is a membrane-bound ATPase within the ESX-5 secretion system complex. The complex is critical for mycobacterium viability and virulence in the host cell and mutations contribute to a decreased uptake of antibiotic in the outer membrane, yet the Relational Sequencing Tuberculosis Data platform (ReSeqTB, https://platform.reseqtb.org) finds no evidence of an association between eccC5 mutations and drug resistance. PMID:30337678 Mtub_eccC5_FLO Mutations in the eccC5 gene contributing to antibiotic resistance to fluoroquinolone. antibiotic_resistance ARO:3004920 fluoroquinolone resistant eccC5 Mutations that occur in ahpC that result in ahpC overexpression thus conferring or contributing to resistance to isoniazid. Mtub_ahpC_INH antibiotic_resistance ARO:3004921 Mycobacterium tuberculosis ahpC mutations confer resistance to isoniazid Mutations that occur in ahpC that result in ahpC overexpression thus conferring or contributing to resistance to isoniazid. PMID:8830260 Mtub_ahpC_INH Mutations that occur in fabG1 resulting in or contributing to resistance in isoniazid. Mtub_fabG1_INH antibiotic_resistance ARO:3004922 Mycobacterium tuberculosis fabG1 mutations confer resistance to isoniazid Mutations that occur in fabG1 resulting in or contributing to resistance in isoniazid. PMID:16189082 Mtub_fabG1_INH Mutations that occur in furA that result in or contribute to antibiotic resistance to isoniazid. Mtub_furA_INH antibiotic_resistance ARO:3004923 Mycobacterium tuberculosis furA mutations confer resistance to isoniazid Mutations that occur in furA that result in or contribute to antibiotic resistance to isoniazid. PMID:24055765 PMID:25092698 Mtub_furA_INH Mutations that occur in inbR that result in or contribute to antibiotic resistance to isoniazid. Mtub_inbR_INH antibiotic_resistance ARO:3004924 Mycobacterium tuberculosis inbR mutations conferring resistance to isoniazid Mutations that occur in inbR that result in or contribute to antibiotic resistance to isoniazid. PMID:26353937 Mtub_inbR_INH Mutations that occur in Mycobacterium tuberculosis mshA that result in or contribute to antibiotic resistance to isoniazid. Mtub_mshA_INH antibiotic_resistance ARO:3004925 Mycobacterium tuberculosis mshA mutations conferring resistance to isoniazid Mutations that occur in Mycobacterium tuberculosis mshA that result in or contribute to antibiotic resistance to isoniazid. PMID:30583053 Mtub_mshA_INH Mutations that occur in mshC that result in or contribute to antibiotic resistance to isoniazid. Mtub_mshC_INH antibiotic_resistance ARO:3004927 Mycobacterium tuberculosis mshC mutations conferring resistance to isoniazid Mutations that occur in mshC that result in or contribute to antibiotic resistance to isoniazid. PMID:26104204 Mtub_mshC_INH Mutations that occur in the mymA operon that result in or contribute to antibiotic resistance to isoniazid. Mtub_mymA_INH antibiotic_resistance ARO:3004928 Mycobacterium tuberculosis mymA mutations conferring resistance to isoniazid Mutations that occur in the mymA operon that result in or contribute to antibiotic resistance to isoniazid. PMID:30082293 Mtub_mymA_INH Mutations that occur in mmaA3 that result in or contribute to antibiotic resistance to isoniazid. Mtub_mmaA3_INH antibiotic_resistance ARO:3004929 Mycobacterium tuberculosis mmaA3 mutations conferring resistance to isoniazid Mutations that occur in mmaA3 that result in or contribute to antibiotic resistance to isoniazid. PMID:21426023 PMID:33055230 Mtub_mmaA3_INH Mutations that occur in nat which through overexpression of the enzyme can result in or contribute to antibiotic resistance to isoniazid. Mtub_nat_INH antibiotic_resistance ARO:3004930 Mycobacterium tuberculosis nat mutations conferring resistance to isoniazid Mutations that occur in nat which through overexpression of the enzyme can result in or contribute to antibiotic resistance to isoniazid. PMID:26104204 Mtub_nat_INH Mutations that occur in nudC which through overexpression of the enzyme can result in or contribute to antibiotic resistance to isoniazid. Mtub_nudC_INH antibiotic_resistance ARO:3004931 Mycobacterium tuberculosis nudC mutations conferring resistance to isoniazid Mutations that occur in nudC which through overexpression of the enzyme can result in or contribute to antibiotic resistance to isoniazid. PMID:26104204 Mtub_nudC_INH Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid. Mtub_sigI_INH antibiotic_resistance ARO:3004932 Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid. PMID:26104204 Mtub_sigI_INH Mutations that occur in Mycobacterium tuberculosis fabG1 resulting in or contributing to resistance in ethionamide. Mtub_fabG1_ETO antibiotic_resistance ARO:3004933 Mycobacterium tuberculosis fabG1 mutation conferring resistance to ethionamide Mutations that occur in Mycobacterium tuberculosis fabG1 resulting in or contributing to resistance in ethionamide. PMID:16189082 Mtub_fabG1_ETO Mutations that occur in mshC resulting in or contributing to conferring resistance to ethionamide. Mtub_mshC_ETO antibiotic_resistance ARO:3004934 Mycobacterium tuberculosis mshC mutations conferring resistance to ethionamide Mutations that occur in mshC resulting in or contributing to conferring resistance to ethionamide. PMID:26104204 Mtub_mshC_ETO Mutations that occur in nudC resulting in or contributing to conferring resistance to ethionamide. Mtub_nudC_ETO antibiotic_resistance ARO:3004935 Mycobacterium tuberculosis nudC mutations conferring resistance to ethionamide Mutations that occur in nudC resulting in or contributing to conferring resistance to ethionamide. PMID:26104204 Mtub_nudC_ETO Point mutations in the 23S rRNA of bacteria can confer resistance to aminoglycosides. antibiotic_resistance ARO:3004936 23s rRNA with mutation conferring resistance to aminoglycoside antibiotics Point mutations in 23S rRNA of Mycobacterium tuberculosis can confer resistance to capreomycin. Mtub_23S_CAP antibiotic_resistance ARO:3004937 Mycobacterium tuberculosis 23S rRNA mutation conferring resistance to capreomycin Point mutations in 23S rRNA of Mycobacterium tuberculosis can confer resistance to capreomycin. PMID:16857584 Mtub_23S_CAP Mutations in the D-alanine synthase of Mycobacterium tuberculosis can confer resistance to antibiotics. antibiotic_resistance ARO:3004938 antibiotic resistant ddlA ddlA catalyzes the ATP-driven ligation of two D-alanine molecules to form the D-alanyl-D-alanine dipeptide, key in forming the cell wall. Cycloserine has a similar structure to d-alanine and inhibits the growth of the cell wall. antibiotic_resistance ARO:3004939 cycloserine resistant ddlA Point mutations that occur within Mycobacterium tuberculosis ddlA gene resulting in resistance to cycloserine. Mtub_ddlA_DCS antibiotic_resistance ARO:3004941 Mycobacterium tuberculosis ddlA mutations confer resistance to cycloserine Point mutations that occur within Mycobacterium tuberculosis ddlA gene resulting in resistance to cycloserine. PMID:28231674 Mtub_ddlA_DCS Mutations that occur in ald which decreases effective functioning of antibiotics. antibiotic_resistance ARO:3004942 antibiotic resistant ald ald plays a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer. Resistance due to mutations in ald can cause cycloserine to not function. antibiotic_resistance ARO:3004943 cycloserine resistant ald Mutations that occur in alr which decreases effective functioning of antibiotics. antibiotic_resistance ARO:3004944 antibiotic resistant alr Mutations in the ald gene that contribute to or confer resistance to cycloserine. Mtub_ald_DCS antibiotic_resistance ARO:3004945 Mycobacterium tuberculosis ald mutations confer resistance to cycloserine Mutations in the ald gene that contribute to or confer resistance to cycloserine. PMID:27064254 Mtub_ald_DCS Provides the D-alanine required for cell wall biosynthesis. Transforms L-alanine to D-alanine. Can confer resistance to cycloserine. antibiotic_resistance ARO:3004946 cycloserine resistant alr Mutations in the alr mutation contribute to or confer resistance to cycloserine. Mtub_alr_DCS antibiotic_resistance ARO:3004947 Mycobacterium tuberculosis alr with mutation conferring resistance to cycloserine Mutations in the alr mutation contribute to or confer resistance to cycloserine. PMID:28971867 Mtub_alr_DCS Decaprenylphosphoryl-5-phosphoribose (DPPR) synthase involved in arabinogalactan synthesis. antibiotic_resistance ARO:3004948 antibiotic resistant ubiA DDPR synthase involved in arabinogalactan synthesis. Mutations can confer resistance to ethambutol. antibiotic_resistance ARO:3004949 ethambutol resistant ubiA Mutations in the ubiA gene contribute to or confer resistance to ethambutol. Mtub_ubiA_EMB antibiotic_resistance ARO:3004950 Mycobacterium tuberculosis ubiA mutations confer resistance to ethambutol Mutations in the ubiA gene contribute to or confer resistance to ethambutol. PMID:30711156 Mtub_ubiA_EMB Mutations in aftA gene contribute to or confer resistance to ethamutol. Mtub_aftA_EMB antibiotic_resistance ARO:3004951 Mycobacterium tuberculosis aftA mutations confer resistance to ethambutol Mutations in aftA gene contribute to or confer resistance to ethamutol. PMID:23995136 PMID:29084750 Mtub_aftA_EMB Thioacetazone is an inexpensive, antitubercular, bacteriostatic drug that has been widely used in combination with isoniazid in Africa and South America. This drug is rarely in use. pubchem.compound:9568512 amithiozone thiacetazone antibiotic_resistance ARO:3004952 thioacetazone Thioacetazone is an inexpensive, antitubercular, bacteriostatic drug that has been widely used in combination with isoniazid in Africa and South America. This drug is rarely in use. PMID:18094751 Rv0565c is a bacterial monoxygenase that has been newly uncovered in recent literature to show resistance to antibiotic. antibiotic_resistance ARO:3004953 antibiotic resistant Rv0565c Mycobacterial monoxygenase has been shown to confer resistance to ethionamide in recent literature. antibiotic_resistance ARO:3004954 Ethionamide resistant Rv0565c Mutations in a bacterial monooxygenase, Rv0565c, are significantly associated with ethionamide resistance as an activator of ethionamide. Mtub_Rv0565_ETO antibiotic_resistance ARO:3004955 Mycobacterium tuberculosis Rv0565c mutation conferring resistance to ethionamide Mutations in a bacterial monooxygenase, Rv0565c, are significantly associated with ethionamide resistance as an activator of ethionamide. PMID:31015328 Mtub_Rv0565_ETO rpld encodes for the 50S L4 ribosomal protein, is a macrolide resistance protein identified in Neisseria gonorrhoeae. Ngon_rpld antibiotic_resistance ARO:3004956 Neisseria gonorrhoeae rpld rpld encodes for the 50S L4 ribosomal protein, is a macrolide resistance protein identified in Neisseria gonorrhoeae. PMID:26935729 PMID:27638945 Ngon_rpld Mutations that occur in clpC1 that result in or contribute to antibiotic resistance to pyrazinamide. Mtub_clpC1_PZA antibiotic_resistance ARO:3004957 Mycobacterium tuberculosis clpC1 with mutation conferring resistance to pyrazinamide Mutations that occur in clpC1 that result in or contribute to antibiotic resistance to pyrazinamide. PMID:28271875 PMID:33722890 Mtub_clpC1_PZA A probable bifunctional penicillin-binding protein that is involved in the final stages of peptidoglycan synthesis. It has been shown to cause resistance to antibiotics. antibiotic_resistance ARO:3004958 antibiotic resistant ponA1 Mutations in the ponA1 gene that can contribute to or confer resistance to rifamycin-class antibiotics. antibiotic_resistance ARO:3004959 rifamycin resistant ponA1 Mutations in ponA1 that contribute to or confer resistance to rifabutin antibiotic. Mtub_ponA1_RFB antibiotic_resistance ARO:3004960 Mycobacterium tuberculosis ponA1 mutations confer resistance to rifabutin Mutations in ponA1 that contribute to or confer resistance to rifabutin antibiotic. PMID:23995135 PMID:24962424 Mtub_ponA1_RFB Mutations in the eis gene that can contribute to antibiotic resistance. antibiotic_resistance ARO:3004961 antibiotic resistant eis Involved in acetylation and intracellular survival. Associated with the cell surface and secretion proteins. antibiotic_resistance ARO:3004962 kanamycin resistant eis Mutations in eis that contribute to or confer resistance to kanamycin. Mtub_eis_KAN antibiotic_resistance ARO:3004963 Mycobacterium tuberculosis eis mutations confer resistance to kanamycin Mutations in eis that contribute to or confer resistance to kanamycin. PMID:19906990 Mtub_eis_KAN Mutations in the whib7 gene that cause antibiotic resistance. antibiotic_resistance ARO:3004964 antibiotic resistant whib7 A protein involved in transcriptional mechanisms. Mutations in the gene can cause resistance to streptomycin. antibiotic_resistance ARO:3004965 streptomycin resistant whib7 whib7 is a protein involved in transcriptional mechanisms. Mutations in the gene can cause resistance to kanamycin. antibiotic_resistance ARO:3004966 Kanamycin resistant whib7 Mutations in whib7 that can contribute to or confer resistance to kanamycin. Mtub_whib7_KAN antibiotic_resistance ARO:3004967 Mycobacterium tuberculosis whib7 mutations confer resistance to kanamycin Mutations in whib7 that can contribute to or confer resistance to kanamycin. PMID:23380727 Mtub_whib7_KAN Mutations in whib7 that can contribute to or confer resistance to streptomycin. Mtub_whib7_STR whmC antibiotic_resistance ARO:3004968 Mycobacterium tuberculosis whib7 mutation conferring resistance to streptomycin Mutations in whib7 that can contribute to or confer resistance to streptomycin. PMID:23380727 Mtub_whib7_STR An efflux pump in mycobacterium that contributes to intrinsic antibiotic resistance. The pump uses the electrochemical gradient as a source of energy. antibiotic_resistance ARO:3004970 streptomycin resistant Rv1258c Mutations in the Rv1258c (Tap) gene that can contribute to or confer resistance to streptomycin. Mtub_tap_STR antibiotic_resistance ARO:3004971 Mycobacterium tuberculosis Rv1258c mutations confer resistance to streptomycin Mutations in the Rv1258c (Tap) gene that can contribute to or confer resistance to streptomycin. PMID:30837962 Mtub_tap_STR Mutations in ppsA can result in antibiotic resistance. antibiotic_resistance ARO:3004972 antibiotic resistant ppsA Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. Mutations in the gene may confer resistance to pyrazinamide. antibiotic_resistance ARO:3004973 pyrazinamide resistant ppsA Mutations in ppsC can contribute to or confer resistance to pyrazinamide. Mtub_ppsC_PZA antibiotic_resistance ARO:3004975 Mycobacterium tuberculosis ppsC mutations confer resistance to pyrazinamide Mutations in ppsC can contribute to or confer resistance to pyrazinamide. PMID:29686155 Mtub_ppsC_PZA Mutations in ppsD can contribute to or confer resistance to pyrazinamide. Mtub_ppsD_PZA antibiotic_resistance ARO:3004976 Mycobacterium tuberculosis ppsD mutations confer resistance to pyrazinamide Mutations in ppsD can contribute to or confer resistance to pyrazinamide. PMID:30333483 Mtub_ppsD_PZA Mutations in gpsI that can contribute to or confer resistance to pyrazinamide. Mtub_gpsI_PZA antibiotic_resistance ARO:3004977 Mycobacterium tuberculosis gpsI with mutations conferring resistance to pyrazinamide Mutations in gpsI that can contribute to or confer resistance to pyrazinamide. PMID:29020922 Mtub_gpsI_PZA Mutations in mas that can contribute to or confer resistance to pyrazinamide. Mtub_mas_PZA antibiotic_resistance ARO:3004978 Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide Mutations in mas that can contribute to or confer resistance to pyrazinamide. PMID:27759369 Mtub_mas_PZA Mutations in the gene can contribute to antibiotic resistance. Chloramphenicol efflux pump Rv0191 antibiotic_resistance ARO:3004979 antibiotic resistant Rv0191 A probable conserved integral membrane protein that acts as an active efflux pump. Overexpression causes pyrazinamide resistance. antibiotic_resistance ARO:3004980 pyrazinamide resistant Rv0191 Mutations in the Rv0191 gene contribute to or confer resistance to pyrazinamide. Mtub_Rv0191_PZA antibiotic_resistance ARO:3004981 Mycobacterium tuberculosis Rv0191 mutations confer resistance to pyrazinamide Mutations in the Rv0191 gene contribute to or confer resistance to pyrazinamide. PMID:28584158 Mtub_Rv0191_PZA Mutations in the Rv1667 gene can contribute or confer resistance to antibiotics. antibiotic_resistance ARO:3004982 antibiotic resistant Rv1667 A probable transport protein thought to be involved in the active transport of macrolide across the membrane in mycobacterium. antibiotic_resistance ARO:3004983 pyrazinamide resistant Rv1667 Mutations in the Rv1667 gene that can contribute to or confer resistance to pyrazinamide. Resistance may be due to an antibiotic export mechanism. Mtub_Rv1667_PZA antibiotic_resistance ARO:3004984 Mycobacterium tuberculosis Rv1667 mutations confer resistance to pyrazinamide Mutations in the Rv1667 gene that can contribute to or confer resistance to pyrazinamide. Resistance may be due to an antibiotic export mechanism. PMID:28584158 Mtub_Rv1667_PZA Mutations in the Rv2731 gene that contribute to antibiotic resistance. antibiotic_resistance ARO:3004985 antibiotic resistant Rv2731 A conserved alanine and arginine-rich protein with an unknown function. The protein has shown to contribute to or confer resistance to pyrazinamide. antibiotic_resistance ARO:3004986 pyrazinamide resistant Rv2731 Mutations in the Rv2731 gene that contribute to or confer resistance to pyrazinamide. Mtub_Rv2731_PZA antibiotic_resistance ARO:3004987 Mycobacterium tuberculosis Rv2731 mutations confer resistance to pyrazinamide Mutations in the Rv2731 gene that contribute to or confer resistance to pyrazinamide. PMID:29020922 Mtub_Rv2731_PZA Mutations in Rv3008 can contribute to or confer resistance to antibiotics. antibiotic_resistance ARO:3004988 antibiotic resistant Rv3008 A hypothetical protein for which it has been predicted but no experimental evidence exists to determine its function. May contribute to pyrazinamide resistance. antibiotic_resistance ARO:3004989 pyrazinamide resistant Rv3008 Mutations in the Rv3169 gene contribute to or confer resistance to antibiotics. antibiotic_resistance ARO:3004991 antibiotic resistant Rv3169 A conserved protein with an unknown function determined through proteomics study. May contribute or confer resistance to pyrazinamide resistance. antibiotic_resistance ARO:3004992 pyrazinamide resistant Rv3169 Mutations in the Rv3169 gene that can contribute to or confer resistance to pyrazinamide resistance. Mtub_Rv3169_PZA antibiotic_resistance ARO:3004993 Mycobacterium tuberculosis Rv3169 mutations confer resistance to pyrazinamide Mutations in the Rv3169 gene that can contribute to or confer resistance to pyrazinamide resistance. PMID:29020922 Mtub_Rv3169_PZA Mutations in rpoC that contribute to or confer resistance to rifampicin antibiotic. Mtub_rpoC_RIF antibiotic_resistance ARO:3004994 Mycobacterium tuberculosis rpoC mutations confer resistance to rifampicin Mutations in rpoC that contribute to or confer resistance to rifampicin antibiotic. PMID:23208709 Mtub_rpoC_RIF rpoC catalyzes the transcription of DNA into RNA and mutations confer resistance to rifampicin. antibiotic_resistance ARO:3004995 rifampicin resistant rpoC RNA polymerase is a multisubunit enzyme that is necessary for transcription. Catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. antibiotic_resistance ARO:3004996 antibiotic sensitive beta-prime subunit of RNA polymerase (rpoA) RNA polymerase is a multisubunit enzyme that is necessary for transcription. Mutations in rpoA gene confer antibiotic resistance. antibiotic_resistance ARO:3004997 antibiotic resistant rpoA rpoA catalyzes the transcription of DNA into RNA and mutations confer resistance to rifampicin. antibiotic_resistance ARO:3004998 rifampicin resistant rpoA Mutations in rpoA that contribute to or confer resistance to rifampicin antibiotic. Mtub_rpoA_RIF antibiotic_resistance ARO:3004999 Mycobacterium tuberculosis rpoA mutations confer resistance to rifampicin Mutations in rpoA that contribute to or confer resistance to rifampicin antibiotic. PMID:23208709 Mtub_rpoA_RIF Point mutations in DNA gyrase subunit B (gyrB) of Neisseria gonorrhoeae can result in resistance to Zoliflodacin. antibiotic_resistance ARO:3005000 Zoliflodacin resistant gyrB Nucleotide point mutations in the 50S rRNA subunit (not in the 23s rRNA range) may confer resistance to macrolide antibiotics. antibiotic_resistance ARO:3005001 50S rRNA with mutation conferring resistance to macrolide antibiotics Genes ppsA-E constitute an operon encoding enzymes involved in the biosynthesis of phthiocerol dimycocerosate and other lipids in Mycobacterium tuberculosis. Mutations within this region can result in resistance to pyrazinamide. antibiotic_resistance ARO:3005002 antibiotic resistant polyketide synthase genes Mutations in the prokaryotic 50S ribosomal RNA subunit which disrupt binding sites and thereby reduce antibiotic efficacy. antibiotic_resistance ARO:3005003 50S rRNA with mutation conferring antibiotic resistance Mutation in the mtrC efflux pump of Neisseria gonorrhoea shown to confer resistance to azithromycin, a macrolide type antibiotic. Ngon_mtrC_AZM antibiotic_resistance ARO:3005004 Neisseria gonorrhoeae mtrC with mutation conferring resistance to azithromycin Mutation in the mtrC efflux pump of Neisseria gonorrhoea shown to confer resistance to azithromycin, a macrolide type antibiotic. PMID:21933917 Ngon_mtrC_AZM Known antibiotic-resistant variants of emb arabinosyltransferases, primarily in Mycobacterium and conferring resistance to ethambutol through point mutation. antibiotic_resistance ARO:3005005 antibiotic-resistant emb arabinosyltransferase Known antibiotic-resistant variants of emb arabinosyltransferases, primarily in Mycobacterium and conferring resistance to ethambutol through point mutation. PMID:18174142 A tetracycline efflux MFS Transporter from Providencia sp. Y14. tet(57) antibiotic_resistance ARO:3005006 tet(57) A tetracycline efflux MFS Transporter from Providencia sp. Y14. PMID:11381101 tet(57) QnrVC2 is a class 1 integron found in Ciprofloxacin-resistant Vibro choleraeO1. QnrVC2 antibiotic_resistance ARO:3005007 QnrVC2 QnrVC2 is a class 1 integron found in Ciprofloxacin-resistant Vibro choleraeO1. PMID:18598639 QnrVC2 TxR is a putative transcription regulator that plays a role in conferring tetracycline resistance. It is required for proper functioning of Tet35. TxR antibiotic_resistance ARO:3005008 TxR TxR is a putative transcription regulator that plays a role in conferring tetracycline resistance. It is required for proper functioning of Tet35. PMID:11897587 TxR QacE is a resistance gene conferring resistance to antiseptics. qacE antibiotic_resistance ARO:3005009 qacE QacE is a resistance gene conferring resistance to antiseptics. PMID:10339831 qacE QacEdelta1 is a resistance gene conferring resistance to antiseptics. It is different from QacE only at the 3'-terminus. qacEdelta1 antibiotic_resistance ARO:3005010 qacEdelta1 QacEdelta1 is a resistance gene conferring resistance to antiseptics. It is different from QacE only at the 3'-terminus. PMID:10339831 qacEdelta1 IDC beta-lactamases are class C beta-lactamases inc. cephalosporinases and carbapenemases. antibiotic_resistance ARO:3005011 IDC beta-lactamase IDC beta-lactamases are class C beta-lactamases inc. cephalosporinases and carbapenemases. PMID:32183280 IDC-2 is an IDC beta-lactamase and an integron cephalosprinase. IDC-1 antibiotic_resistance ARO:3005012 IDC-1 IDC-2 is an IDC beta-lactamase and an integron cephalosprinase. PMID:32183280 IDC-1 IDC-2 is an IDC beta-lactamase and an integron cephalosprinase. IDC-2 antibiotic_resistance ARO:3005013 IDC-2 IDC-2 is an IDC beta-lactamase and an integron cephalosprinase. PMID:32183280 IDC-2 Vibro metallo-B-lactamase, also known as VMB is a carbapenemase beta-lactamase gene family. antibiotic_resistance ARO:3005014 VMB beta-lactamase Vibro metallo-B-lactamase, also known as VMB is a carbapenemase beta-lactamase gene family. PMID:32293144 Vibrio metallo-B-lactamase 1, also known as VMB-1, is carbapenemase beta-lactamase that is found in plasmid pVB1796 from Vibrio alginolyticus. VMB-1 antibiotic_resistance ARO:3005015 VMB-1 Vibrio metallo-B-lactamase 1, also known as VMB-1, is carbapenemase beta-lactamase that is found in plasmid pVB1796 from Vibrio alginolyticus. PMID:32293144 VMB-1 CMY-150 is a CMY-2 variant differing by 15 amino-acid substitutions. It confers higher resistance levels to ceftazidime and aztreonam compared to CMY-2. CMY-150 antibiotic_resistance ARO:3005016 CMY-150 CMY-150 is a CMY-2 variant differing by 15 amino-acid substitutions. It confers higher resistance levels to ceftazidime and aztreonam compared to CMY-2. PMID:31785341 CMY-150 LMB is an AMR Gene family belonging to subclass B3 metallo-beta-lactamases. antibiotic_resistance ARO:3005017 LMB beta-lactamase LMB is an AMR Gene family belonging to subclass B3 metallo-beta-lactamases. PMID:31785341 LMB-1 is a subclass B3 metallo-beta-lactamase that confers resistance to penams, cephalosporins, and carbapenems. LMB-1 antibiotic_resistance ARO:3005018 LMB-1 LMB-1 is a subclass B3 metallo-beta-lactamase that confers resistance to penams, cephalosporins, and carbapenems. PMID:31785341 LMB-1 IMP-68 is a subclass B1 metallo-beta-lactamase that confers resistance to carbapenems. IMP-68 antibiotic_resistance ARO:3005019 IMP-68 IMP-68 is a subclass B1 metallo-beta-lactamase that confers resistance to carbapenems. PMID:31666316 IMP-68 The cfr(D) group are cfr(D) genes found in Enterococcus faecium that confer resistance to vancomycin, teicoplanin and linezolid. antibiotic_resistance ARO:3005020 cfr(D) Group The cfr(D) group are cfr(D) genes found in Enterococcus faecium that confer resistance to vancomycin, teicoplanin and linezolid. PMID:31685464 PMID:32277823 cfr(D) is found in Enterococcus faecium. It confers resistance to vancomycin, teicoplanin, and linezolid. cfr(D) antibiotic_resistance ARO:3005021 cfr(D) cfr(D) is found in Enterococcus faecium. It confers resistance to vancomycin, teicoplanin, and linezolid. PMID:31685464 PMID:32277823 cfr(D) cfr(E) is a cfr-like gene described by (Stojkovic et al, 2019). It is found on transposon Tn6218 and found in Clostridioides difficile. antibiotic_resistance ARO:3005022 cfr(E) Group cfr(E) is a cfr-like gene described by (Stojkovic et al, 2019). It is found on transposon Tn6218 and found in Clostridioides difficile. PMID:31685464 The gene cfr(E) is a cfr-like gene found in Clostridioides difficile isolate DF11. It confers resistance to antibiotics targeting to the 23s rRNA through hypermethylation of nucleotide A2503. cfr(E) cfrE antibiotic_resistance ARO:3005023 cfrE The gene cfr(E) is a cfr-like gene found in Clostridioides difficile isolate DF11. It confers resistance to antibiotics targeting to the 23s rRNA through hypermethylation of nucleotide A2503. PMID:31685464 cfrE FosL1 is related to FosA-like genes. It is a plasmid-encoded fosfomycin resistant gene found in E. coli. FosL1 antibiotic_resistance ARO:3005024 FosL1 FosL1 is related to FosA-like genes. It is a plasmid-encoded fosfomycin resistant gene found in E. coli. PMID:31932373 FosL1 Antibiotic adjuvants shown to inhibit the action of ATP synthase, restoring antibiotic activity by depolarizing the bacterial membrane. antibiotic_resistance ARO:3005025 ATP synthase inhibitor Venturicidin A is an ATP synthase inhibitor and antibiotic adjuvant produced in actinomycetes. In the presence of aminoglycoside antibiotics such as gentamicin, Venturicidin A showed to restore susceptibility to aminoglycosides in resistant bacteria. pubchem.compound:6438066 VentA antibiotic_resistance ARO:3005026 venturicidin A Venturicidin A is an ATP synthase inhibitor and antibiotic adjuvant produced in actinomycetes. In the presence of aminoglycoside antibiotics such as gentamicin, Venturicidin A showed to restore susceptibility to aminoglycosides in resistant bacteria. PMID:32424122 FRI-4 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae. FRI-4 antibiotic_resistance ARO:3005027 FRI-4 FRI-4 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae. PMID:30060114 FRI-4 FRI-5 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter cloacae. FRI-5 antibiotic_resistance ARO:3005028 FRI-5 FRI-5 FRI-6 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter cloacae. FRI-6 antibiotic_resistance ARO:3005029 FRI-6 FRI-6 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter cloacae. PMID:31725164 FRI-6 FRI-7 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae. FRI-7 antibiotic_resistance ARO:3005030 FRI-7 FRI-7 FRI-8 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter sp. 18A13. It is from a plasmid. FRI-8 antibiotic_resistance ARO:3005031 FRI-8 FRI-8 FRI-9 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae. FRI-9 antibiotic_resistance ARO:3005032 FRI-9 FRI-9 FLC-1 is part of the FRI beta-lactamase family. It is a class A carbapenem-hydrolyzing beta-lactamase from Enterobacter cloacae. FLC-1 antibiotic_resistance ARO:3005033 FLC-1 FLC-1 YRC is a ambler class C beta-lactamase from Yersinia ruckeri. It confers resistance penams and cephalosporins. antibiotic_resistance ARO:3005034 YRC Beta-lactamase YRC is a ambler class C beta-lactamase from Yersinia ruckeri. It confers resistance penams and cephalosporins. PMID:16553832 Yrc-1 is a ampC-like beta-lactamase that confers resistance to penams and cephalosporins. It is an ambler class C beta-lactamase. Yrc-1 antibiotic_resistance ARO:3005035 Yrc-1 Yrc-1 is a ampC-like beta-lactamase that confers resistance to penams and cephalosporins. It is an ambler class C beta-lactamase. PMID:16553832 Yrc-1 BLMT is a bleomycin (Bm) resistance protein, encoded by the ble gene on the transposon Tn5. This protein confers a survival advantage to Escherichia coli host cells. BLMT confers resistance to bleomycin. BLMT antibiotic_resistance ARO:3005036 BLMT BLMT is a bleomycin (Bm) resistance protein, encoded by the ble gene on the transposon Tn5. This protein confers a survival advantage to Escherichia coli host cells. BLMT confers resistance to bleomycin. PMID:9923599 BLMT ADC-159 is an ADC beta-lactamase and a ambler class C beta-lactamase. ADC-159 antibiotic_resistance ARO:3005037 ADC-159 ADC-159 PDC-65 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-65 antibiotic_resistance ARO:3005038 PDC-65 PDC-65 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-65 PDC-55 is an ambler class C beta-lactamase from Pseudomonas aeruginosa. PDC-55 antibiotic_resistance ARO:3005039 PDC-55 PDC-55 is an ambler class C beta-lactamase from Pseudomonas aeruginosa. PMID:25022578 PDC-55 YajC interacts with the AcrAB-TolC efflux pump in a way that in uncharacterized but is shown to grant increased fitness in the presence of linezolid, rifampicin, and vancomycin. YajC antibiotic_resistance ARO:3005040 YajC YajC interacts with the AcrAB-TolC efflux pump in a way that in uncharacterized but is shown to grant increased fitness in the presence of linezolid, rifampicin, and vancomycin. PMID:31871033 YajC mlaF from the mla system is a gene proposed to play a part in the transport of phospholipids to the outer membrane. Insertions in mlaF are shown to confer resistance to linezolid. mlaF antibiotic_resistance ARO:3005041 mlaF mlaF from the mla system is a gene proposed to play a part in the transport of phospholipids to the outer membrane. Insertions in mlaF are shown to confer resistance to linezolid. PMID:31871033 mlaF mlaD from the mla system is a gene proposed to play a part in the transport of phospholipids to the outer membrane. Insertions in mlaD are shown to confer resistance to linezolid. mlaD antibiotic_resistance ARO:3005042 mlaD mlaD from the mla system is a gene proposed to play a part in the transport of phospholipids to the outer membrane. Insertions in mlaD are shown to confer resistance to linezolid. PMID:31871033 mlaD cmlA9 is a Major Facilitator Superfamily efflux gene that is found in Salmonella enterica. FloR2 cmlA9 antibiotic_resistance ARO:3005043 cmlA9 cmlA9 is a Major Facilitator Superfamily efflux gene that is found in Salmonella enterica. PMID:25315365 cmlA9 OmpA is a porin that confers resistance to beta-lactam antibiotics. OmpA antibiotic_resistance ARO:3005044 OmpA OmpA is a porin that confers resistance to beta-lactam antibiotics. PMID:25341126 OmpA SatA is part of the Streptothricin acetyltransferase gene family. It confers resistance to nucleoside antibiotics. SatA antibiotic_resistance ARO:3005045 SatA SatA is part of the Streptothricin acetyltransferase gene family. It confers resistance to nucleoside antibiotics. PMID:12721629 SatA This MecI is a methicillin-resistant repressor resembling MecC. It confers resistance to penams. MecI_rep antibiotic_resistance ARO:3005046 MecC-type methicillin resistance repressor MecI This MecI is a methicillin-resistant repressor resembling MecC. It confers resistance to penams. PMID:21641281 MecI_rep eptB is a phosphoethanolamine transferase. It confers resistance to peptide antibiotics. eptB antibiotic_resistance ARO:3005047 eptB eptB is a phosphoethanolamine transferase. It confers resistance to peptide antibiotics. PMID:21629720 eptB CrcB is part of the Camphor Resistance Protein Family. It confers resistance to aminoglycoside antibiotics. CrcB antibiotic_resistance ARO:3005049 CrcB CrcB is part of the Camphor Resistance Protein Family. It confers resistance to aminoglycoside antibiotics. PMID:23405357 PMID:35631066 CrcB LpsB is involved in lipopolysaccharide synthesis. It provides intrinsic resistance to colistin and other peptide antibiotics such as polymyxins. antibiotic_resistance ARO:3005050 Intrinsic peptide antibiotic resistant Lps LpsB is involved in lipopolysaccharide synthesis. It provides intrinsic resistance to colistin and other peptide antibiotics such as polymyxins. PMID:23230287 LpsB is involved in lipopolysaccharide synthesis. It confers intrinsic resistance to colistin and other peptide antibiotics. LpsB antibiotic_resistance ARO:3005051 LpsB LpsB is involved in lipopolysaccharide synthesis. It confers intrinsic resistance to colistin and other peptide antibiotics. PMID:23230287 LpsB LpsA plays a role in Lipooligosaccharide biosynthesis. LpsA confers resistance to polymyxin antibiotics. LpsA antibiotic_resistance ARO:3005052 LpsA LpsA plays a role in Lipooligosaccharide biosynthesis. LpsA confers resistance to polymyxin antibiotics. PMID:16847057 PMID:23980106 PMID:32284036 LpsA ArnT is involved in Cell Wall Biosynthesis, specifically 4-amino-4-deoxy-L-arabinose (Ara4N). It confers resistance to peptide antibiotics. ArnT antibiotic_resistance ARO:3005053 ArnT ArnT is involved in Cell Wall Biosynthesis, specifically 4-amino-4-deoxy-L-arabinose (Ara4N). It confers resistance to peptide antibiotics. PMID:25341126 ArnT Tet(X6) is a tetracycline inactivating enzyme. It is a tet(X) variant. tet(X6) tetX6 antibiotic_resistance ARO:3005056 tet(X6) Tet(X6) is a tetracycline inactivating enzyme. It is a tet(X) variant. PMID:32068864 tet(X6) Tet(X5) is a tetracycline inactivating enzyme. It is a variant of tet(X). tet(X5) tetX5 antibiotic_resistance ARO:3005057 tet(X5) Tet(X5) is a tetracycline inactivating enzyme. It is a variant of tet(X). PMID:31611352 tet(X5) ABC transporter complex which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. antibiotic_resistance ARO:3005058 mlaFEDB ABC transporter complex which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. PMID:19383799 PMID:27529189 PMID:31871033 LptD is involved in LPS transport in a ABC Transporter efflux system. It confers resistance to rifamycin, aminocoumarin, and peptide antibiotics. LptD antibiotic_resistance ARO:3005059 LptD LptD is involved in LPS transport in a ABC Transporter efflux system. It confers resistance to rifamycin, aminocoumarin, and peptide antibiotics. PMID:22914622 PMID:31281307 LptD A class D OXA-like beta-lactamase described in the emerging pathogen Cupriavidus gilardii. OXA-837 antibiotic_resistance ARO:3005060 OXA-837 A class D OXA-like beta-lactamase described in the emerging pathogen Cupriavidus gilardii. PMID:31578249 OXA-837 A novel aminoglycoside resistance gene identified from Cupriavidus gilardii; AAC(3)-IVb / aacC10 is an aminoglycoside-3-N-acetyltransferase gene which confers resistance to gentamicin and tobramycin. AAC(3)-IVb aacC10 antibiotic_resistance ARO:3005061 AAC(3)-IVb A novel aminoglycoside resistance gene identified from Cupriavidus gilardii; AAC(3)-IVb / aacC10 is an aminoglycoside-3-N-acetyltransferase gene which confers resistance to gentamicin and tobramycin. PMID:31578249 AAC(3)-IVb A novel aminoglycoside 3''-adenyltransferase gene and aminoglycoside resistance gene identified from Cupriavidus gilardii. ANT(3'')-Ib / aadA32 confers resistance to spectinomycin and streptomycin. ANT(3'')-Ib aadA32 antibiotic_resistance ARO:3005062 ANT(3'')-Ib A novel aminoglycoside 3''-adenyltransferase gene and aminoglycoside resistance gene identified from Cupriavidus gilardii. ANT(3'')-Ib / aadA32 confers resistance to spectinomycin and streptomycin. PMID:31578249 ANT(3'')-Ib cprR is one part of a two-component regulatory system. It with its counterpart cprS induce the Arn operon to confer resistance to peptide antibiotics. cprR antibiotic_resistance ARO:3005063 cprR cprR is one part of a two-component regulatory system. It with its counterpart cprS induce the Arn operon to confer resistance to peptide antibiotics. PMID:23006746 cprR cprS is part of a two-component regulatory system that, with its counterpart cprR, induces the Arn operon in the presence of cationic peptides to confer resistance. cprS antibiotic_resistance ARO:3005064 cprS cprS is part of a two-component regulatory system that, with its counterpart cprR, induces the Arn operon in the presence of cationic peptides to confer resistance. PMID:23006746 cprS cprRS is a two-component regulatory system. In the presence of cationic peptides, it induces the Arn operon to confer resistance. antibiotic_resistance ARO:3005065 cprRS cprRS is a two-component regulatory system. In the presence of cationic peptides, it induces the Arn operon to confer resistance. PMID:10984043 PMID:15608211 PMID:18978025 PMID:23006746 parRS is a two-component sensor that mediates MexXY/OprM and porin OprD to confer resistance to polycationic antibiotics. It has multiple mechanisms of resistance such as LPS modification, efflux mediation and reduced porin pathway. antibiotic_resistance ARO:3005066 parRS parRS is a two-component sensor that mediates MexXY/OprM and porin OprD to confer resistance to polycationic antibiotics. It has multiple mechanisms of resistance such as LPS modification, efflux mediation and reduced porin pathway. PMID:10984043 PMID:15608211 PMID:18978025 PMID:21149619 ParS is the sensor component of the two-component ParRS system. Alongside its counterpart ParR, it confers resistance to polycationic antibiotics though regulation of efflux pumps and porins. ParS antibiotic_resistance ARO:3005067 ParS ParS is the sensor component of the two-component ParRS system. Alongside its counterpart ParR, it confers resistance to polycationic antibiotics though regulation of efflux pumps and porins. PMID:10984043 PMID:15608211 PMID:18978025 PMID:21149619 ParS ParR is a component of the two-component sensor ParRS. Alongside its counterpart ParS, it confers resistance to polycationic antibiotics through the regulation of efflux components and porins. ParR antibiotic_resistance ARO:3005068 ParR ParR is a component of the two-component sensor ParRS. Alongside its counterpart ParS, it confers resistance to polycationic antibiotics through the regulation of efflux components and porins. PMID:10984043 PMID:15608211 PMID:18978025 PMID:21149619 ParR rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA. csrA rsmA antibiotic_resistance ARO:3005069 rsmA rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA. PMID:11673439 PMID:16622241 rsmA A glycopeptide antibiotic which binds to essential peptidoglycan hydrolases, thereby preventing autolysis and inhibited cell wall remodelling during growth. pubchem.compound:16134403 antibiotic_resistance ARO:3005070 complestatin A glycopeptide antibiotic which binds to essential peptidoglycan hydrolases, thereby preventing autolysis and inhibited cell wall remodelling during growth. PMID:32051588 A glycopeptide antibiotic which binds to essential peptidoglycan hydrolases, thereby preventing autolysis and cell wall remodelling. pubchem.compound:163285731 antibiotic_resistance ARO:3005071 corbomycin A glycopeptide antibiotic which binds to essential peptidoglycan hydrolases, thereby preventing autolysis and cell wall remodelling. PMID:32051588 ROB-13 is a beta-lactamase from the blaROB AMR gene family. It was found in Bibersteinia trehalosi. ROB-13 antibiotic_resistance ARO:3005072 ROB-13 ROB-13 ROB-3 is a beta-lactamase from the blaROB AMR gene family. It was found in Moraxella pluranimalium. ROB-3 antibiotic_resistance ARO:3005073 ROB-3 ROB-3 ROB-4 is a beta-lactamase from the blaROB AMR gene family. It was found in Moraxella porci. ROB-4 antibiotic_resistance ARO:3005074 ROB-4 ROB-4 ROB-5 is a class A beta-lactamase from the blaROB AMR gene family. It was found in Moraxella sp. RCAD0137. ROB-5 antibiotic_resistance ARO:3005075 ROB-5 ROB-5 ROB-6 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al. ROB-6 antibiotic_resistance ARO:3005076 ROB-6 ROB-6 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al. PMID:26229982 ROB-6 ROB-7 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al. ROB-7 antibiotic_resistance ARO:3005077 ROB-7 ROB-7 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al. PMID:26229982 ROB-7 ROB-8 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al. ROB-8 antibiotic_resistance ARO:3005078 ROB-8 ROB-8 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al. PMID:26229982 ROB-8 ROB-2 is an extended spectrum class A beta-lactamase from the blaROB AMR gene family It is described by Kadlec et al. ROB-2 antibiotic_resistance ARO:3005079 ROB-2 ROB-2 is an extended spectrum class A beta-lactamase from the blaROB AMR gene family It is described by Kadlec et al. PMID:30561662 ROB-2 ROB-10 is a class A beta-lactamase from the blaROB AMR gene family. It was found in Glaesserella parasuis. ROB-10 antibiotic_resistance ARO:3005080 ROB-10 ROB-10 Thermus thermophilus ribosomal protein uL3 containing various mutations conferring resistance to tiamulin. Mutations in the ribosomal protein of uL3 acts by interfering with local rRNA conformation thus conferring resistance. Tthe_uL3_PLM antibiotic_resistance ARO:3005081 Thermus thermophilus uL3 mutations conferring resistance to pleuromutilin antibiotics Thermus thermophilus ribosomal protein uL3 containing various mutations conferring resistance to tiamulin. Mutations in the ribosomal protein of uL3 acts by interfering with local rRNA conformation thus conferring resistance. PMID:32526926 Tthe_uL3_PLM Ribosomal protein mutations that interfere with the rRNA conformation at the active site thus conferring antibiotic resistance. antibiotic_resistance ARO:3005082 Ribosomal protein mutation conferring resistance to pleuromutilin antibiotics Ribosomal protein mutations that interfere with the rRNA conformation at the active site thus conferring antibiotic resistance. PMID:32526926 Mutations in the 23s rRNA of Thermus thermophilus confers resistance to pleuromutilin antibiotics such as tiamulin. Tthe_23S_PLM antibiotic_resistance ARO:3005083 Thermus thermophilus 23s rRNA conferring resistance to pleuromutilin antibiotics Mutations in the 23s rRNA of Thermus thermophilus confers resistance to pleuromutilin antibiotics such as tiamulin. PMID:32526926 Tthe_23S_PLM dfrA31 is an antibiotic resistance dihydrofolate reductase from an integron found from Vibrio cholerae. dfrA31 antibiotic_resistance ARO:3005084 dfrA31 dfrA31 is an antibiotic resistance dihydrofolate reductase from an integron found from Vibrio cholerae. PMID:22782487 PMID:23162539 dfrA31 AAC(3)-IIg is part of the AAC(3) family. It was initially found in clinical isolates of Enterobacter cloacae. AAC(3)-IIg antibiotic_resistance ARO:3005085 AAC(3)-IIg AAC(3)-IIg is part of the AAC(3) family. It was initially found in clinical isolates of Enterobacter cloacae. PMID:32571822 AAC(3)-IIg Fusidic acid resistance determinants through the mediation of target protection. These protein drive the dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. antibiotic_resistance ARO:3005086 Target protecting FusB-type protein conferring resistance to Fusidic acid Fusidic acid resistance determinants through the mediation of target protection. These protein drive the dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. PMID:21968364 PMID:22308410 PMID:26781961 msrF is an ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics. msrF antibiotic_resistance ARO:3005087 msrF msrF is an ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics. PMID:32122903 msrF msrH is a ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics. msrH antibiotic_resistance ARO:3005088 msrH msrH is a ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics. PMID:32122903 msrH mef(D) is a major facilitator superfamily efflux pump protein. It works together with the msr proteins to confer resistance to macrolide antibiotics. mef(D) antibiotic_resistance ARO:3005089 mef(D) mef(D) is a major facilitator superfamily efflux pump protein. It works together with the msr proteins to confer resistance to macrolide antibiotics. PMID:32122903 mef(D) RanB is the determinant of antibiotic resistance within the RanARanB ABC-type efflux system. It confers resistance to aminoglycoside antibiotics. RanB antibiotic_resistance ARO:3005090 RanB RanB is the determinant of antibiotic resistance within the RanARanB ABC-type efflux system. It confers resistance to aminoglycoside antibiotics. PMID:32273020 RanB RanA is a part of the RanARanB ABC-type efflux system. Alongside RanB, it confers resistance to aminoglycoside antibiotics. RanA antibiotic_resistance ARO:3005091 RanA RanA is a part of the RanARanB ABC-type efflux system. Alongside RanB, it confers resistance to aminoglycoside antibiotics. PMID:32273020 RanA RanARanB is the combination of both RanA and RanB to form an ABC-type efflux system. RanB confers resistance to aminoglycoside antibiotics. antibiotic_resistance ARO:3005092 RanARanB RanARanB is the combination of both RanA and RanB to form an ABC-type efflux system. RanB confers resistance to aminoglycoside antibiotics. PMID:32273020 OXA-899 is a class D beta-lactamase and part of the OXA family. It confers resistance to B-lactams and was originally found in Ralstonia pikettii. OXA-899 antibiotic_resistance ARO:3005093 OXA-899 OXA-899 is a class D beta-lactamase and part of the OXA family. It confers resistance to B-lactams and was originally found in Ralstonia pikettii. PMID:32169680 OXA-899 OXA-898 is a class D beta-lactamase from the OXA family. It confers resistance to B-lactams and was originally found in Ralstonia pikettii. OXA-898 antibiotic_resistance ARO:3005094 OXA-898 OXA-898 is a class D beta-lactamase from the OXA family. It confers resistance to B-lactams and was originally found in Ralstonia pikettii. PMID:32169680 OXA-898 GPC is a class A beta-lactamase family. It is found initially in Pseudomonas aeruginosa. It confers resistance to B-lactams. antibiotic_resistance ARO:3005095 GPC beta-lactamase GPC is a class A beta-lactamase family. It is found initially in Pseudomonas aeruginosa. It confers resistance to B-lactams. PMID:31960033 GPC-1 is a class A beta-lactamase. It is part of the GPC beta-lactamase gene family. Originally found in Pseudomonas aeruginosa. Confers resistance to B-lactams. GPC-1 antibiotic_resistance ARO:3005096 GPC-1 GPC-1 is a class A beta-lactamase. It is part of the GPC beta-lactamase gene family. Originally found in Pseudomonas aeruginosa. Confers resistance to B-lactams. PMID:31960033 GPC-1 A blaZ-like beta-lactamase found in S. Aureus. mecC-type_BlaZ antibiotic_resistance ARO:3005097 mecC-type BlaZ A blaZ-like beta-lactamase found in S. Aureus. PMID:21636525 mecC-type_BlaZ A subunit of the qac multidrug efflux pump in Vibrio cholerae. qacL antibiotic_resistance ARO:3005098 qacL A subunit of the qac multidrug efflux pump in Vibrio cholerae. PMID:16801431 qacL Variant of ErmA (ARO:3000347) found in Streptococcus pyogenes. Confers the MLSb phenotype. Spyo_ErmA_MLSb ermTR antibiotic_resistance ARO:3005099 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) Variant of ErmA (ARO:3000347) found in Streptococcus pyogenes. Confers the MLSb phenotype. PMID:9527769 Spyo_ErmA_MLSb Subtype of FosB (ARO:3000172). Present in multiple species. FosB2 antibiotic_resistance ARO:3005100 FosB2 Subtype of FosB (ARO:3000172). Present in multiple species. PMID:12721629 FosB2 Mutations associated with katG conferring resistance to prothionamide, an analogue of isoniazid. Like isoniazid, prothionamide targets lnhA. antibiotic_resistance ARO:3005101 prothionamide resistant katG Mutations associated with katG conferring resistance to prothionamide, an analogue of isoniazid. Like isoniazid, prothionamide targets lnhA. PMID:30583053 Mutations in Mycobacterium tuberculosis katG conferring resistance to prothionamide, an analogue of isoniazid. Mtub_katG_PTO antibiotic_resistance ARO:3005102 Mycobacterium tuberculosis katG mutations conferring resistance to prothionamide Mutations in Mycobacterium tuberculosis katG conferring resistance to prothionamide, an analogue of isoniazid. PMID:30583053 Mtub_katG_PTO Mutations in ethA conferring resistance to isoniazid. antibiotic_resistance ARO:3005103 isoniazid resistant ethA Mutations in ethA conferring resistance to isoniazid. PMID:30583053 Mutations in ethA conferring resistance to prothionamide, an analogue of isoniazid. antibiotic_resistance ARO:3005104 prothionamide resistant ethA Mutations in ethA conferring resistance to prothionamide, an analogue of isoniazid. PMID:30583053 Mutations in Mycobacterium tuberculosis ethA conferring resistance to isoniazid. Mtub_ethA_INH antibiotic_resistance ARO:3005105 Mycobacterium tuberculosis ethA mutations conferring resistance to isoniazid Mutations in Mycobacterium tuberculosis ethA conferring resistance to isoniazid. PMID:19486070 PMID:30583053 Mtub_ethA_INH Mutations in Mycobacterium tuberculosis ethA conferring resistance to prothionamide, an analogue to isoniazid. Mtub_ethA_PTO antibiotic_resistance ARO:3005106 Mycobacterium tuberculosis ethA mutations conferring resistance to prothionamide Mutations in Mycobacterium tuberculosis ethA conferring resistance to prothionamide, an analogue to isoniazid. PMID:30583053 Mtub_ethA_PTO Mutations in mshA conferring resistance to prothionamide, an analogue of isoniazid. antibiotic_resistance ARO:3005107 prothionamide resistant mshA Mutations in Mycobacterium tuberculosis mshA conferring resistance to prothionamide, an analogue to isoniazid. Mtub_mshA_PTO antibiotic_resistance ARO:3005108 Mycobacterium tuberculosis mshA mutations conferring resistance to prothionamide Mutations in Mycobacterium tuberculosis mshA conferring resistance to prothionamide, an analogue to isoniazid. PMID:30583053 Mtub_mshA_PTO A class A beta-lactamase in Mycolicibacterium smegmatis. antibiotic_resistance ARO:3005110 blaS A class A beta-lactamase in Mycolicibacterium smegmatis. PMID:15699201 PMID:9103972 Predominant beta-lactamase in Mycolicibacterium smegmatis. blaS1 antibiotic_resistance ARO:3005111 blaS1 Predominant beta-lactamase in Mycolicibacterium smegmatis. PMID:15699201 PMID:9103972 blaS1 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Aeromonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. AAC(6')-Ib-cr3 antibiotic_resistance ARO:3005112 AAC(6')-Ib-cr3 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Aeromonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. PMID:25691640 AAC(6')-Ib-cr3 A subfamily of aminoglycoside 6'-N-acetyltransferases, AAC(6'), which doubly confer resistance to aminoglycoside and fluoroquinolone antibiotics through fluoroquinolone-acetylating activity. antibiotic_resistance ARO:3005113 AAC(6')-Ib-cr A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Enterobacter. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. AAC(6')-Ib-cr4 antibiotic_resistance ARO:3005114 AAC(6')-Ib-cr4 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Enterobacter. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. PMID:23361643 AAC(6')-Ib-cr4 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Pseudomonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. AAC(6')-Ib-cr5 antibiotic_resistance ARO:3005115 AAC(6')-Ib-cr5 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Pseudomonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. PMID:34909689 AAC(6')-Ib-cr5 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Escherichia coli. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. AAC(6')-Ib-cr6 antibiotic_resistance ARO:3005116 AAC(6')-Ib-cr6 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Escherichia coli. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. PMID:33295867 AAC(6')-Ib-cr6 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Klebsiella. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. AAC(6')-Ib-cr7 antibiotic_resistance ARO:3005117 AAC(6')-Ib-cr7 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Klebsiella. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. PMID:25691640 AAC(6')-Ib-cr7 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant, identified from Salmonella. These variants confers resistance to both aminoglycoside and fluoroquinolone antibiotics. AAC(6')-Ib-cr8 antibiotic_resistance ARO:3005118 AAC(6')-Ib-cr8 AAC(6')-Ib-cr8 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant, identified from Serratia. These variants confers resistance to both aminoglycoside and fluoroquinolone antibiotics. AAC(6')-Ib-cr9 antibiotic_resistance ARO:3005119 AAC(6')-Ib-cr9 AAC(6')-Ib-cr9 A novel broad-spectrum anti-MRSA benzoquinolizine antibiotic effective against gram-positive and gram-negative pathogens. pubchem.compound:9850038 antibiotic_resistance ARO:3005120 levonadifloxacin A novel broad-spectrum anti-MRSA benzoquinolizine antibiotic effective against gram-positive and gram-negative pathogens. PMID:31920285 The lsa(D) gene represents an ABC-F subfamily protein expressed in Lactococcus garvieae. It confers resistance to Streptogramins A, Pleuromutilins and Lincosamides. lsa(D) lsaD antibiotic_resistance ARO:3005121 lsaD The lsa(D) gene represents an ABC-F subfamily protein expressed in Lactococcus garvieae. It confers resistance to Streptogramins A, Pleuromutilins and Lincosamides. PMID:32706619 lsaD PDC-68 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-68 antibiotic_resistance ARO:3005122 PDC-68 PDC-68 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-68 PDC-70 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-70 antibiotic_resistance ARO:3005123 PDC-70 PDC-70 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-70 PDC-63 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-63 antibiotic_resistance ARO:3005124 PDC-63 PDC-63 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-63 PDC-57 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-57 antibiotic_resistance ARO:3005125 PDC-57 PDC-57 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-57 PDC-66 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-66 antibiotic_resistance ARO:3005126 PDC-66 PDC-66 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-66 PDC-14 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-14 antibiotic_resistance ARO:3005127 PDC-14 PDC-14 PDC-47 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-47 antibiotic_resistance ARO:3005128 PDC-47 PDC-47 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-47 PDC-51 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-51 antibiotic_resistance ARO:3005129 PDC-51 PDC-51 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-51 OXA-846 is a class D beta-lactamase found in Pseudomonas aeruginosa. It is part of the OXA-50 family of oxacillin-hydrolyzing beta-lactamase. OXA-846 antibiotic_resistance ARO:3005130 OXA-846 OXA-846 An NDM metallo-beta-lactamase variant reported in Klebsiella pneumoniae. Sourced from NCBI's Pathogen Reference Gene Browser; no peer-reviewed article. NDM-29 antibiotic_resistance ARO:3005131 NDM-29 NDM-29 PDC-11 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-11 antibiotic_resistance ARO:3005132 PDC-11 PDC-11 PDC-62 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-62 antibiotic_resistance ARO:3005133 PDC-62 PDC-62 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-62 PDC-43 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-43 antibiotic_resistance ARO:3005134 PDC-43 PDC-43 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-43 PDC-54 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-54 antibiotic_resistance ARO:3005135 PDC-54 PDC-54 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-54 OXA-906 is a class D beta-lactamase from the OXA-50 family found in Pseudomonas aeruginosa. OXA-906 antibiotic_resistance ARO:3005136 OXA-906 OXA-906 PDC-59 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-59 antibiotic_resistance ARO:3005137 PDC-59 PDC-59 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-59 Pseudomonas aeruginosa strain OXA-50 family oxacillin-hydrolyzing class D beta-lactamase. OXA-850 antibiotic_resistance ARO:3005138 OXA-850 OXA-850 PDC-67 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 5065. PDC-67 antibiotic_resistance ARO:3005139 PDC-67 PDC-67 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 5065. PMID:25022578 PDC-67 PDC-56 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 4883. PDC-56 antibiotic_resistance ARO:3005140 PDC-56 PDC-56 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 4883. PMID:25022578 PDC-56 PDC-52 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-52 antibiotic_resistance ARO:3005141 PDC-52 PDC-52 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-52 PDC-44 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-44 antibiotic_resistance ARO:3005142 PDC-44 PDC-44 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-44 PDC-240 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-240 antibiotic_resistance ARO:3005143 PDC-240 PDC-240 PDC-61 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-61 antibiotic_resistance ARO:3005144 PDC-61 PDC-61 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-61 PDC-45 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-45 antibiotic_resistance ARO:3005145 PDC-45 PDC-45 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-45 PDC-49 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-49 antibiotic_resistance ARO:3005146 PDC-49 PDC-49 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-49 PDC-50 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-50 antibiotic_resistance ARO:3005147 PDC-50 PDC-50 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-50 PDC-48 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-48 antibiotic_resistance ARO:3005148 PDC-48 PDC-48 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-48 PAC beta-lactamase is an inhibitior-resistant cephalosporin-hydrolyzing class C beta-lactamase. antibiotic_resistance ARO:3005149 PAC beta-lactamase PAC-1 is an ambler class C beta-lactamase from the PAC beta-lactamase family. It is found in Pseudomonas aeruginosa. PAC-1 antibiotic_resistance ARO:3005150 PAC-1 PAC-1 PDC-53 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-53 antibiotic_resistance ARO:3005151 PDC-53 PDC-53 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-53 PDC-72 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-72 antibiotic_resistance ARO:3005152 PDC-72 PDC-72 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-72 PDC-69 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-69 antibiotic_resistance ARO:3005153 PDC-69 PDC-69 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-69 PDC-23 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-23 antibiotic_resistance ARO:3005155 PDC-23 PDC-23 PDC-28 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-28 antibiotic_resistance ARO:3005156 PDC-28 PDC-28 PDC-41 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-41 antibiotic_resistance ARO:3005157 PDC-41 PDC-41 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-41 OXA-668 is a class D beta-lactamase from the OXA-274 family of OXA beta-lactamases. OXA-668 antibiotic_resistance ARO:3005158 OXA-668 OXA-668 OXA-818 is a class D beta-lactamase from the OXA-23 family of OXA beta-lactamases. OXA-818 antibiotic_resistance ARO:3005159 OXA-818 OXA-818 OXA-812 is a class D beta-lactamase from the OXA-23 family of OXA beta-lactamases. OXA-812 antibiotic_resistance ARO:3005160 OXA-812 OXA-812 FosA7.5 is a variant of the FosA7 gene. This gene is unique from FosA7 in that it is found in Escherichia coli as opposed to Salmonella enterica. It confers resistance to fosfomycin. FosA7.5 antibiotic_resistance ARO:3005162 FosA7.5 FosA7.5 is a variant of the FosA7 gene. This gene is unique from FosA7 in that it is found in Escherichia coli as opposed to Salmonella enterica. It confers resistance to fosfomycin. PMID:33077665 FosA7.5 Ionophores are chemical entities which reversibly bind ions. Many ionophores display antibacterial and antifungal properties. An ionophore will bind and transport ions through a cell membrane, thereby potentially disrupting membrane potential and modifying permeability. antibiotic_resistance ARO:3005163 ionophore with antibiotic activity Ionophores are chemical entities which reversibly bind ions. Many ionophores display antibacterial and antifungal properties. An ionophore will bind and transport ions through a cell membrane, thereby potentially disrupting membrane potential and modifying permeability. PMID:22849267 dfrA35 is a trimethoprim resistant dihydrofolate reductase gene found in the lncC plasmid pEc158 from E.coli. dfrA35 antibiotic_resistance ARO:3005164 dfrA35 dfrA35 is a trimethoprim resistant dihydrofolate reductase gene found in the lncC plasmid pEc158 from E.coli. PMID:30989199 dfrA35 In an antimicrobial context, a drug class is a set of antibiotic molecules, including antibiotic/adjuvant combination medications, with similar chemical structures, molecular targets, and/or modes and mechanisms of action. antibiotic_resistance ARO:3005165 antibiotic drug class Tetracycline resistance gene tet(X) ortholog described by Fang et al. 2020. tet(X1) tetX1 antibiotic_resistance ARO:3005166 tet(X1) Tetracycline resistance gene tet(X) ortholog described by Fang et al. 2020. PMID:32567703 tet(X1) A class of organic compounds derived from aromatic compounds and exhibiting antibiotic activity. antibiotic_resistance ARO:3005167 quinone with antibiotic activity A class of compounds containing an aromatic moiety and an aliphatic chain, produced as a bacterial metabolite and exhibiting antibiotic properties to many gram-positive pathogens. antibiotic_resistance ARO:3005168 ansamycin antibiotic Alkaloids are naturally occurring organic compounds containing the element nitrogen. Some alkaloid compounds exhibit specific antibacterial activity. antibiotic_resistance ARO:3005169 alkaloids with antibiotic activity A metallophore is any organic substance capable of carrying a metallic element such as zinc or iron, typically through chelation. Some metallophores exhibit specific antibiotic activity. antibiotic_resistance ARO:3005170 metallophores with antibiotic activity Polyketides are a large group of secondary metabolites. Some polyketide compounds have been shown to possess antibiotic activity and qualities. antibiotic_resistance ARO:3005171 polyketide with antibiotic activity Terpenes are a large class of naturally produced organic compounds, predominantly produced by plants such as conifers. Some terpenes have been shown to possess antibiotic qualities or activity. antibiotic_resistance ARO:3005172 terpene with antibiotic activity Derivatives of thiacalixarene exhibit antiseptic and antibacterial activity. pubchem.compound:335377 antibiotic_resistance ARO:3005174 thiacalixarene derivatives Derivatives of thiacalixarene exhibit antiseptic and antibacterial activity. PMID:33310546 Perchlozone is a novel thiosemicarbazone used for the treatment of multidrug-resistant tuberculosis. It is similar to thiacetazone with only a different side chain attached to the thiosemicarbazone moiety. Perchlozone is a prodrug that is activated by ethA and inhibits the HadABC complex. pubchem.compound:5374694 4-thioureido-iminomethylpyridinium perchlorate antibiotic_resistance ARO:3005175 perchlozone Perchlozone is a novel thiosemicarbazone used for the treatment of multidrug-resistant tuberculosis. It is similar to thiacetazone with only a different side chain attached to the thiosemicarbazone moiety. Perchlozone is a prodrug that is activated by ethA and inhibits the HadABC complex. PMID:25704063 PMID:33022959 CMY-158 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 06-NOV-2018. CMY-158 antibiotic_resistance ARO:3005176 CMY-158 CMY-158 CMY-173 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 23-SEP-2020. CMY-173 antibiotic_resistance ARO:3005177 CMY-173 CMY-173 Mutations in ethA conferring resistance to perchlozone, a novel thiosemicarbazone. Mtub_ethA_PCL antibiotic_resistance ARO:3005178 Mycobacterium tuberculosis ethA mutations conferring resistance to perchlozone Mutations in ethA conferring resistance to perchlozone, a novel thiosemicarbazone. PMID:33022959 Mtub_ethA_PCL CMY-147 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 23-FEB-2017. CMY-147 antibiotic_resistance ARO:3005180 CMY-147 CMY-147 CMY-146 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 18-JAN-2017. CMY-146 antibiotic_resistance ARO:3005181 CMY-146 CMY-146 CMY-156 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 14-FEB-2018. CMY-156 antibiotic_resistance ARO:3005182 CMY-156 CMY-156 CMY-160 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 29-MAY-2018. CMY-160 antibiotic_resistance ARO:3005183 CMY-160 CMY-160 CMY-162 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 21-JUN-2018. CMY-162 antibiotic_resistance ARO:3005184 CMY-162 CMY-162 CMY-140 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 09-JUN-2018. CMY-140 antibiotic_resistance ARO:3005185 CMY-140 CMY-140 CMY-164 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 26-JUN-2019. CMY-164 antibiotic_resistance ARO:3005186 CMY-164 CMY-164 CMY-161 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 24-MAY-2018. CMY-161 antibiotic_resistance ARO:3005187 CMY-161 CMY-161 CMY-165 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 23-AUG-2019. CMY-165 antibiotic_resistance ARO:3005188 CMY-165 CMY-165 CMY-166 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 23-AUG-2019. CMY-166 antibiotic_resistance ARO:3005189 CMY-166 CMY-166 CMY-149 is a beta-lactamase found in Proteus mirabilis. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-MAY-2017. CMY-149 antibiotic_resistance ARO:3005190 CMY-149 CMY-149 CMY-139 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 07-JUN-2016. CMY-139 antibiotic_resistance ARO:3005191 CMY-139 CMY-139 CMY-148 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-MAY-2017. CMY-148 antibiotic_resistance ARO:3005192 CMY-148 CMY-148 CMY-163 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 25-JUN-2018. CMY-163 antibiotic_resistance ARO:3005193 CMY-163 CMY-163 CMY-154 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 21-JUN-2017. CMY-154 antibiotic_resistance ARO:3005194 CMY-154 CMY-154 CMY-142 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 05-JUN-2016. CMY-142 antibiotic_resistance ARO:3005195 CMY-142 CMY-142 CMY-141 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 09-JUN-2018. CMY-141 antibiotic_resistance ARO:3005196 CMY-141 CMY-141 CMY-145 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 18-JAN-2017. CMY-145 antibiotic_resistance ARO:3005197 CMY-145 CMY-145 CMY-96 is a beta-lactamase found in Citrobacter sp. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 09-NOV-2018. CMY-157 antibiotic_resistance ARO:3005198 CMY-157 CMY-157 CMY-171 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 14-APR-2020. CMY-171 antibiotic_resistance ARO:3005199 CMY-171 CMY-171 CMY-155 is a beta-lactamase found in Klebsiella sp. KF07. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-AUG-2017. CMY-155 antibiotic_resistance ARO:3005200 CMY-155 CMY-155 An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor. pubchem.compound:10890081 N,N'-bis(2-pyridylmethyl)-ethylenediamine antibiotic_resistance ARO:3005201 bispicen An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor. PMID:33285370 An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor. pubchem.compound:15845745 N,N,N'-tris(2-pyridylmethyl)-ethylenediamine antibiotic_resistance ARO:3005202 trispicen An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor. PMID:33285370 CMY-143 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 16-NOV-2016. CMY-143 antibiotic_resistance ARO:3005204 CMY-143 CMY-143 Genetic variants of ethA from Mycobacterium spp. including tuberculosis, which confer resistance to the antibiotic perchlozone. antibiotic_resistance ARO:3005205 perchlozone resistant ethA A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-Nov-2018. SHV-205 antibiotic_resistance ARO:3005207 SHV-205 SHV-205 A beta-lactamase gene from Klebsiella pneumoniae. Submitted directly to NCBI without publication on 07-NOV-2018. SHV-222 antibiotic_resistance ARO:3005208 SHV-222 SHV-222 A beta-lactamase gene from Klebsiella pneumoniae. Submitted directly to NCBI without publication on 10-AGU-2017. SHV-198 antibiotic_resistance ARO:3005209 SHV-198 SHV-198 Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication. SHV-195 antibiotic_resistance ARO:3005210 SHV-195 SHV-195 Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication. SHV-201 antibiotic_resistance ARO:3005211 SHV-201 SHV-201 A beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-212 antibiotic_resistance ARO:3005212 SHV-212 SHV-212 A beta-lactamase gene from Klebsiella pneumoniae. Submitted directly to NCBI without publication on 26-JUN-2018. SHV-204 antibiotic_resistance ARO:3005213 SHV-204 SHV-204 A beta-lactamase gene from Escherichia coli. Directly submitted to NCBI without publication on 05-JAN-2017. SHV-197 antibiotic_resistance ARO:3005214 SHV-197 SHV-197 A beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-216 antibiotic_resistance ARO:3005215 SHV-216 SHV-216 CMY-152 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 25-APR-2017. CMY-152 antibiotic_resistance ARO:3005216 CMY-152 CMY-152 CMY-151 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 17-MAR-2017. CMY-151 antibiotic_resistance ARO:3005217 CMY-151 CMY-151 CMY-89 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-MAY-2017. CMY-153 antibiotic_resistance ARO:3005218 CMY-153 CMY-153 CMY-144 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 01-NOV-2016. CMY-144 antibiotic_resistance ARO:3005219 CMY-144 CMY-144 CMY-138 is a beta-lactamase found in Proteus mirabilis. It confers resistance to cephamycin. Detected directly from NCBI and submitted without publication on 04-NOV-2015. CMY-138 antibiotic_resistance ARO:3005220 CMY-138 CMY-138 Novel mcr-3.41 gene identified in an Aeromonas veronii C198 isolate from a patient with Septicemia in Thailand by Hatrongjit et. al. MCR-3.41 antibiotic_resistance ARO:3005221 MCR-3.41 Novel mcr-3.41 gene identified in an Aeromonas veronii C198 isolate from a patient with Septicemia in Thailand by Hatrongjit et. al. PMID:33317051 MCR-3.41 OXA-544 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-544 antibiotic_resistance ARO:3005222 OXA-544 OXA-544 Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 04-AUG-2016. SHV-194 antibiotic_resistance ARO:3005223 SHV-194 SHV-194 Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-220 antibiotic_resistance ARO:3005224 SHV-220 SHV-220 Beta-lactamase gene from Klebsiella pneumoniae. Directed submitted to NCBI without publication on 07-NOV-2018. SHV-210 antibiotic_resistance ARO:3005225 SHV-210 SHV-210 A beta-lactamase gene found in Klebsiella pneumoniae. Directly added to NCBI without publication on 07-NOV-2018. SHV-208 antibiotic_resistance ARO:3005226 SHV-208 SHV-208 A beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-206 antibiotic_resistance ARO:3005227 SHV-206 SHV-206 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-226 antibiotic_resistance ARO:3005228 SHV-226 SHV-226 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 19-SEP-2016. SHV-196 antibiotic_resistance ARO:3005229 SHV-196 SHV-196 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 7-NOV-2018. SHV-211 antibiotic_resistance ARO:3005230 SHV-211 SHV-211 Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-219 antibiotic_resistance ARO:3005231 SHV-219 SHV-219 A beta-lactamase gene found in Escherichia coli. Directly submitted to NCBI without publication on 10-AUG-2017. SHV-199 antibiotic_resistance ARO:3005232 SHV-199 SHV-199 Beta-lactamase gene from Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-227 antibiotic_resistance ARO:3005233 SHV-227 SHV-227 A beta-lactamase gene found in Klebsiella pneumonia. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-223 antibiotic_resistance ARO:3005234 SHV-223 SHV-223 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-214 antibiotic_resistance ARO:3005235 SHV-214 SHV-214 A beta-lactamase gene found in Klebsiella penumoniae. Directly submitted to NCBI without publications on 07-NOV-2018. SHV-207 antibiotic_resistance ARO:3005236 SHV-207 SHV-207 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 08-JUN-2016. SHV-1b-b antibiotic_resistance ARO:3005237 SHV-1b-b SHV-1b-b A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-218 antibiotic_resistance ARO:3005238 SHV-218 SHV-218 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 08-JUN-2016. SHV-193 antibiotic_resistance ARO:3005239 SHV-193 SHV-193 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-224 antibiotic_resistance ARO:3005240 SHV-224 SHV-224 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-225 antibiotic_resistance ARO:3005241 SHV-225 SHV-225 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-209 antibiotic_resistance ARO:3005242 SHV-209 SHV-209 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-215 antibiotic_resistance ARO:3005243 SHV-215 SHV-215 ADC ortholog described by Nodari et al. 2020. ADC 181 ADC-181 antibiotic_resistance ARO:3005244 ADC-181 ADC ortholog described by Nodari et al. 2020. PMID:33329450 ADC-181 ADC ortholog described by Nodari et al. 2020. ADC 182 ADC-182 antibiotic_resistance ARO:3005245 ADC-182 ADC ortholog described by Nodari et al. 2020. PMID:33329450 ADC-182 ADC ortholog described by Nodari et al. 2020. ADC 183 ADC-183 antibiotic_resistance ARO:3005246 ADC-183 ADC ortholog described by Nodari et al. 2020. PMID:33329450 ADC-183 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-228 antibiotic_resistance ARO:3005247 SHV-228 SHV-228 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 21-DEC-2017. SHV-200 antibiotic_resistance ARO:3005248 SHV-200 SHV-200 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 21-DEC-2017. SHV-203 antibiotic_resistance ARO:3005249 SHV-203 SHV-203 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-217 antibiotic_resistance ARO:3005250 SHV-217 SHV-217 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-213 antibiotic_resistance ARO:3005251 SHV-213 SHV-213 A beta-lactamase gene found in Klebsiella pneumonia. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-221 antibiotic_resistance ARO:3005252 SHV-221 SHV-221 A beta-lactamase gene found in Klebsiella pneumoniae. Directly submitted to NCBI without publication on 07-NOV-2018. SHV-202 antibiotic_resistance ARO:3005253 SHV-202 SHV-202 TEM-224 is a beta-lactamase. TEM-224 antibiotic_resistance ARO:3005255 TEM-224 TEM-224 TEM-225 is a beta-lactamase. TEM-225 antibiotic_resistance ARO:3005256 TEM-225 TEM-225 TEM-226 is a beta lactamase. TEM-226 antibiotic_resistance ARO:3005257 TEM-226 TEM-226 TEM-227 is a beta-lactamase. TEM-227 antibiotic_resistance ARO:3005258 TEM-227 TEM-227 TEM-228 is a beta lactamase. TEM-228 antibiotic_resistance ARO:3005259 TEM-228 TEM-228 TEM-229 is a beta-lactamase. TEM-229 antibiotic_resistance ARO:3005260 TEM-229 TEM-229 TEM-230 is a beta-lactamase. TEM-230 antibiotic_resistance ARO:3005261 TEM-230 TEM-230 TEM-231 is a beta-lactamase. TEM-231 antibiotic_resistance ARO:3005262 TEM-231 TEM-231 TEM-232 is a beta-lactamase. TEM-232 antibiotic_resistance ARO:3005263 TEM-232 TEM-232 TEM-233 is a beta-lactamase. TEM-233 antibiotic_resistance ARO:3005264 TEM-233 TEM-233 TEM-234 is a beta-lactamase. TEM-234 antibiotic_resistance ARO:3005265 TEM-234 TEM-234 TEM-235 is a beta-lactamase. TEM-235 antibiotic_resistance ARO:3005266 TEM-235 TEM-235 is a beta-lactamase. PMID:19713526 TEM-235 TEM-236 is a beta-lactamase. TEM-236 antibiotic_resistance ARO:3005267 TEM-236 TEM-236 TEM-237 is a beta-lactamase. TEM-237 antibiotic_resistance ARO:3005268 TEM-237 TEM-237 TEM-238 is a beta-lactamase. TEM-238 antibiotic_resistance ARO:3005269 TEM-238 TEM-238 TEM-240 is a beta-lactamase. TEM-240 antibiotic_resistance ARO:3005270 TEM-240 TEM-240 TEM-241 is a beta-lactamase. TEM-241 antibiotic_resistance ARO:3005271 TEM-241 TEM-241 TEM-242 is a beta-lactamase. TEM-242 antibiotic_resistance ARO:3005272 TEM-242 TEM-242 TEM-243 is a beta-lactamase. TEM-243 antibiotic_resistance ARO:3005273 TEM-243 TEM-243 PDC-225 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-225 antibiotic_resistance ARO:3005274 PDC-225 PDC-225 PDC-438 is class C beta-lactamase found in Pseudomonas aeruginosa. PDC-438 antibiotic_resistance ARO:3005275 PDC-438 PDC-438 PDC-284 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-284 antibiotic_resistance ARO:3005276 PDC-284 PDC-284 PDC-105 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-105 antibiotic_resistance ARO:3005277 PDC-105 PDC-105 PDC-118 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-118 antibiotic_resistance ARO:3005278 PDC-118 PDC-118 PDC-324 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-324 antibiotic_resistance ARO:3005279 PDC-324 PDC-324 PDC-323 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-323 antibiotic_resistance ARO:3005280 PDC-323 PDC-323 PDC-258 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-258 antibiotic_resistance ARO:3005281 PDC-258 PDC-258 PDC-413 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-413 antibiotic_resistance ARO:3005282 PDC-413 PDC-413 PDC-384 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-384 antibiotic_resistance ARO:3005283 PDC-384 PDC-384 PDC-264 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-264 antibiotic_resistance ARO:3005284 PDC-264 PDC-264 PDC-201 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-201 antibiotic_resistance ARO:3005285 PDC-201 PDC-201 PDC-346 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-346 antibiotic_resistance ARO:3005286 PDC-346 PDC-346 PDC-285 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-285 antibiotic_resistance ARO:3005287 PDC-285 PDC-285 PDC-337 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-337 antibiotic_resistance ARO:3005288 PDC-337 PDC-337 PDC-212 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-212 antibiotic_resistance ARO:3005289 PDC-212 PDC-212 PDC-352 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-352 antibiotic_resistance ARO:3005290 PDC-352 PDC-352 PDC-464 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-464 antibiotic_resistance ARO:3005291 PDC-464 PDC-464 PDC-19b is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-19b antibiotic_resistance ARO:3005292 PDC-19b PDC-19b PDC-380 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-380 antibiotic_resistance ARO:3005293 PDC-380 PDC-380 PDC-461 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-461 antibiotic_resistance ARO:3005294 PDC-461 PDC-461 PDC-19a is a class C beta-lactamase found in Pseudomonas (multispecies). PDC-19a antibiotic_resistance ARO:3005295 PDC-19a PDC-19a PDC-272 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-272 antibiotic_resistance ARO:3005296 PDC-272 PDC-272 PDC-255 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-255 antibiotic_resistance ARO:3005297 PDC-255 PDC-255 PDC-293 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-293 antibiotic_resistance ARO:3005298 PDC-293 PDC-293 PDC-183 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-183 antibiotic_resistance ARO:3005299 PDC-183 PDC-183 PDC-207 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-207 antibiotic_resistance ARO:3005300 PDC-207 PDC-207 PDC-306 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-306 antibiotic_resistance ARO:3005301 PDC-306 PDC-306 PDC-376 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-376 antibiotic_resistance ARO:3005302 PDC-376 PDC-376 PDC-117 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-117 antibiotic_resistance ARO:3005303 PDC-117 PDC-117 PDC-231 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-231 antibiotic_resistance ARO:3005304 PDC-231 PDC-231 PDC-104 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-104 antibiotic_resistance ARO:3005305 PDC-104 PDC-104 PDC-173 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-173 antibiotic_resistance ARO:3005306 PDC-173 PDC-173 PDC-292 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-292 antibiotic_resistance ARO:3005307 PDC-292 PDC-292 PDC-393 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-393 antibiotic_resistance ARO:3005308 PDC-393 PDC-393 PDC-119 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-119 antibiotic_resistance ARO:3005309 PDC-119 PDC-119 PDC-313 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-313 antibiotic_resistance ARO:3005310 PDC-313 PDC-313 PDC-257 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-257 antibiotic_resistance ARO:3005311 PDC-257 PDC-257 PDC-429 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-429 antibiotic_resistance ARO:3005312 PDC-429 PDC-429 PDC-449 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-449 antibiotic_resistance ARO:3005313 PDC-449 PDC-449 OXA-540 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-540 antibiotic_resistance ARO:3005314 OXA-540 OXA-540 OXA-779 is a beta-lactamase in the OXA-46 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-779 antibiotic_resistance ARO:3005315 OXA-779 OXA-779 OXA-838 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-838 antibiotic_resistance ARO:3005316 OXA-838 OXA-838 OXA-539 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-539 antibiotic_resistance ARO:3005317 OXA-539 OXA-539 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. PMID:28674059 OXA-539 OXA-543 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-543 antibiotic_resistance ARO:3005318 OXA-543 OXA-543 OXA-681 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-681 antibiotic_resistance ARO:3005319 OXA-681 OXA-681 OXA-737 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-737 antibiotic_resistance ARO:3005320 OXA-737 OXA-737 OXA-541 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-541 antibiotic_resistance ARO:3005321 OXA-541 OXA-541 OXA-835 is a beta-lactamase in the OXA-46 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-835 antibiotic_resistance ARO:3005322 OXA-835 OXA-835 OXA-926 is a class D beta-lactamase in the family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-926 antibiotic_resistance ARO:3005323 OXA-926 OXA-926 OXA-570 is a beta-lactamase in the OXA-60 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-570 antibiotic_resistance ARO:3005324 OXA-570 OXA-570 OXA-573 is a beta-lactamase in the OXA-60 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-573 antibiotic_resistance ARO:3005325 OXA-573 OXA-573 OXA-571 is a beta-lactamase in the OXA-60 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-571 antibiotic_resistance ARO:3005326 OXA-571 OXA-571 OXA-672 is a beta-lactamase in the OXA-286 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-672 antibiotic_resistance ARO:3005327 OXA-672 OXA-672 OXA-671 is a beta-lactamase in the OXA-286 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-671 antibiotic_resistance ARO:3005328 OXA-671 OXA-671 OXA-673 is a beta-lactamase in the OXA-286 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-673 antibiotic_resistance ARO:3005329 OXA-673 OXA-673 OXA-931 is a beta-lactamase in the OXA-229 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-931 antibiotic_resistance ARO:3005330 OXA-931 OXA-931 OXA-930 is a beta-lactamase in the OXA-229 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-930 antibiotic_resistance ARO:3005331 OXA-930 OXA-930 OXA-895 is a beta-lactamase in the OXA-229 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-895 antibiotic_resistance ARO:3005332 OXA-895 OXA-895 OXA-641 is a beta-lactamase in the OXA-372 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-641 antibiotic_resistance ARO:3005333 OXA-641 OXA-641 DfrA42 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication. DfrA42 DfrA42_TMP antibiotic_resistance ARO:3005334 Trimethoprim-resistant dihydrofolate reductase DfrA42 DfrA42 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication. PMID:33593833 DfrA42_TMP OXA-496 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-496 antibiotic_resistance ARO:3005335 OXA-496 OXA-496 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. PMID:30150791 OXA-496 OXA-915 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-915 antibiotic_resistance ARO:3005336 OXA-915 OXA-915 OXA-647 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-647 antibiotic_resistance ARO:3005337 OXA-647 OXA-647 OXA-648 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-648 antibiotic_resistance ARO:3005338 OXA-648 OXA-648 OXA-646 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-646 antibiotic_resistance ARO:3005339 OXA-646 OXA-646 OXA-649 is a beta-lactamase in the OXA-143 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-649 antibiotic_resistance ARO:3005340 OXA-649 OXA-649 OXA-897 is a beta-lactamase in the OXA-24 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-897 antibiotic_resistance ARO:3005341 OXA-897 OXA-897 OXA-653 is a beta-lactamase in the OXA-24 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-653 antibiotic_resistance ARO:3005342 OXA-653 OXA-653 OXA-499 is a beta-lactamase in the OXA-143 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-499 antibiotic_resistance ARO:3005343 OXA-499 OXA-499 is a beta-lactamase in the OXA-143 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. PMID:28264850 OXA-499 OXA-825 is a beta-lactamase in the OXA-143 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-825 antibiotic_resistance ARO:3005344 OXA-825 OXA-825 DfrA43 is a dihydrofolate reductase that confers resistance to Trimethoprim. Originially described by Shi YZ et al, 2016, and isolated from Proteus penneri. DfrA43 DfrA43_TMP antibiotic_resistance ARO:3005345 Trimethoprim-resistant dihydrofolate reductase DfrA43 DfrA43 is a dihydrofolate reductase that confers resistance to Trimethoprim. Originially described by Shi YZ et al, 2016, and isolated from Proteus penneri. PMID:33593833 DfrA43_TMP DfrA34 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication. DfrA34 trimethoprim resistant dfra34 antibiotic_resistance ARO:3005346 DfrA34 DfrA34 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication. PMID:30202900 DfrA34 DfrA37 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication. DfrA37 trimethoprim resistant dihydrofolate reductase dfra37 antibiotic_resistance ARO:3005347 DfrA37 DfrA37 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication. PMID:32318052 DfrA37 DfrA36 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally described by Wuthrich et al., 2019, and isolated from Escherichia coli. DfrA36 trimethoprim-resistant dihydrofolate reductase DfrA36 antibiotic_resistance ARO:3005348 DfrA36 DfrA36 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally described by Wuthrich et al., 2019, and isolated from Escherichia coli. PMID:31068437 DfrA36 DfrA38 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication. DfrA38 trimethoprim-resistant dihydrofolate reductase DfrA38 antibiotic_resistance ARO:3005349 DfrA38 DfrA38 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication. PMID:32929451 DfrA38 DfrB9 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication. DfrB9 trimethoprim-resistant dihydrofolate reductase DfrB9 antibiotic_resistance ARO:3005350 DfrB9 DfrB9 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication. PMID:33214838 PMID:33924456 DfrB9 DfrA39 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication. DfrA39 trimethoprim-resistant dihydrofolate reductase DfrA39 antibiotic_resistance ARO:3005351 DfrA39 DfrA39 is a dihydrofolate reductase that confers resistant to Trimethoprim. Detected directly from NCBI and submitted without publication. PMID:34180526 DfrA39 Dfr22 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally detected by Grape et al., (2005) and isolated from Escherichia coli. dfr22 trimethoprim-resistance dihydrofolate reductase type 22 antibiotic_resistance ARO:3005354 dfr22 Dfr22 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally detected by Grape et al., (2005) and isolated from Escherichia coli. PMID:15715715 dfr22 Carbapenem-hydrolyzing class A beta-lactamase kpc-23 [Klebsiella pneumoniae] Accession: WP_111672911.1. KPC-23 antibiotic_resistance ARO:3005356 KPC-23 Carbapenem-hydrolyzing class A beta-lactamase kpc-23 [Klebsiella pneumoniae] Accession: WP_111672911.1. PMID:30928562 KPC-23 Carbapenem-hydrolyzing class A beta-lactamase kpc-25 [Klebsiella pneumoniae] Accession: WP_065419571.1. KPC-25 antibiotic_resistance ARO:3005357 KPC-25 KPC-25 Carbapenem-hydrolyzing class A beta-lactamase kpc-26 [Klebsiella pneumoniae] Accession: WP_068981634.1. KPC-26 antibiotic_resistance ARO:3005358 KPC-26 KPC-26 Carbapenem-hydrolyzing class A beta-lactamase kpc-27 [Klebsiella pneumoniae] Accession: WP_077064886.1. KPC-27 antibiotic_resistance ARO:3005359 KPC-27 KPC-27 Carbapenem-hydrolyzing class A beta-lactamase kpc-29 [Klebsiella pneumoniae] Accession: WP_096807439.1. KPC-29 antibiotic_resistance ARO:3005360 KPC-29 KPC-29 Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-28 [Escherichia coli] Accession: WP_072081992.1. KPC-28 antibiotic_resistance ARO:3005361 KPC-28 Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-28 [Escherichia coli] Accession: WP_072081992.1. PMID:31127297 KPC-28 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-31 [Klebsiella] Accession: WP_073668892.1. KPC-31 antibiotic_resistance ARO:3005362 KPC-31 KPC-31 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-32 [Klebsiella pneumoniae] Accession: WP_073800284.1. KPC-32 antibiotic_resistance ARO:3005363 KPC-32 KPC-32 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-30 [Klebsiella pneumoniae] Accession: WP_085562399.1. KPC-30 antibiotic_resistance ARO:3005364 KPC-30 KPC-30 Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-33 [Klebsiella pneumoniae] Accession: WP_101140102.1. KPC-33 antibiotic_resistance ARO:3005365 KPC-33 KPC-33 Carbapenem-hydrolyzing class A beta-lactamase kpc-34 [Klebsiella pneumoniae] Accession: WP_109545044.1. KPC-34 antibiotic_resistance ARO:3005366 KPC-34 KPC-34 Carbapenem-hydrolyzing class A beta-lactamase kpc-35 [Klebsiella pneumoniae] Accession: WP_111273852.1. KPC-35 antibiotic_resistance ARO:3005367 KPC-35 KPC-35 Carbapenem-hydrolyzing class A beta-lactamase kpc-36 [Klebsiella pneumoniae] Accession: WP_114699267.1. KPC-36 antibiotic_resistance ARO:3005368 KPC-36 KPC-36 Carbapenem-hydrolyzing class A beta-lactamase kpc-37 [Klebsiella pneumoniae] Accession: WP_116786832.1. KPC-37 antibiotic_resistance ARO:3005369 KPC-37 KPC-37 Carbapenem-hydrolyzing class A beta-lactamase kpc-38 [Klebsiella pneumoniae] Accession: WP_123002101.1. KPC-38 antibiotic_resistance ARO:3005370 KPC-38 KPC-38 Carbapenem-hydrolyzing class A beta-lactamase kpc-39 [Klebsiella pneumoniae] Accession: WP_128268237.1. KPC-39 antibiotic_resistance ARO:3005371 KPC-39 KPC-39 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-40 [Enterobacter hormaechei] Accession: WP_115470049.1. KPC-40 antibiotic_resistance ARO:3005372 KPC-40 KPC-40 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-41 [Klebsiella pneumoniae] Accession: WP_148044419.1. KPC-41 antibiotic_resistance ARO:3005373 KPC-41 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-41 [Klebsiella pneumoniae] Accession: WP_148044419.1. PMID:31527032 KPC-41 Carbapenem-hydrolyzing class A beta-lactamase kpc-42 [Klebsiella pneumoniae] Accession: WP_136512070.1. KPC-42 antibiotic_resistance ARO:3005374 KPC-42 KPC-42 Carbapenem-hydrolyzing class A beta-lactamase kpc-43 [Klebsiella pneumoniae] Accession: WP_136512071.1. KPC-43 antibiotic_resistance ARO:3005375 KPC-43 KPC-43 Carbapenem-hydrolyzing class A beta-lactamase kpc-45 [Enterobacter cloacae] Accession: WP_148044420.1. KPC-45 antibiotic_resistance ARO:3005376 KPC-45 KPC-45 Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-46 [Klebsiella pneumoniae] Accession: WP_148044421.1. KPC-46 antibiotic_resistance ARO:3005377 KPC-46 KPC-46 Carbapenem-hydrolyzing class A beta-lactamase kpc-49 [Escherichia coli] Accession: WP_197749402.1. KPC-49 antibiotic_resistance ARO:3005378 KPC-49 KPC-49 Inhibitor-resistant class A beta-lactamase kpc-50 [Klebsiella pneumoniae] Accession: WP_171476788.1. KPC-50 antibiotic_resistance ARO:3005379 KPC-50 KPC-50 Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-51 [Klebsiella pneumoniae] Accession: WP_158208923.1. KPC-51 antibiotic_resistance ARO:3005380 KPC-51 KPC-51 Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-52 [Klebsiella pneumoniae] Accession: WP_158208806.1. KPC-52 antibiotic_resistance ARO:3005381 KPC-52 KPC-52 Carbapenem-hydrolyzing class A beta-lactamase kpc-54 [Klebsiella pneumoniae] Accession: WP_160164839.1. KPC-54 antibiotic_resistance ARO:3005382 KPC-54 KPC-54 Carbapenem-hydrolyzing class A beta-lactamase kpc-55 [Klebsiella pneumoniae] Accession: WP_168247883.1. KPC-55 antibiotic_resistance ARO:3005383 KPC-55 KPC-55 Carbapenem-hydrolyzing class A beta-lactamase kpc-56 [Klebsiella pneumoniae] Accession: WP_087744800.1. KPC-56 antibiotic_resistance ARO:3005384 KPC-56 KPC-56 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-57 [Klebsiella pneumoniae] Accession: WP_171476789.1. KPC-57 antibiotic_resistance ARO:3005385 KPC-57 KPC-57 Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. antibiotic_resistance ARO:3005386 disinfecting agents and antiseptics AAK beta-lactamases are a group of class A beta-lactamases found in Klebsiella pneumoniae. antibiotic_resistance ARO:3005387 AAK beta-lactamase AFM beta-lactamases are class B1 beta-lactamases found in proteobacteria like Pseudomonas aeruginosa. antibiotic_resistance ARO:3005388 AFM beta-lactamase ALG11 beta-lactamases are class B3 beta-lactamases. antibiotic_resistance ARO:3005389 ALG11 beta-lactamase ALG6 beta-lactamases are class B3 beta-lactamases. antibiotic_resistance ARO:3005390 ALG6 beta-lactamases ALI beta-lactamases are class B1 beta-lactamases found in species of the Aliivibrio genus. antibiotic_resistance ARO:3005391 ALI beta-lactamase ANA beta-lactamases are class B1 beta-lactamases found in Anaeromyxobacter. antibiotic_resistance ARO:3005392 ANA beta-lactamase AXC beta-lactamases are class A beta-lactamase found in the Anaeromyxobacter genus. antibiotic_resistance ARO:3005393 AXC beta-lactamase BSU beta-lactamases are class D beta-lactamases found in Bacillus inaquosorum. antibiotic_resistance ARO:3005394 BSU beta-lactamase CAR beta-lactamases are class B3 beta-lactamases found in Pectobacterium atrosepticum. antibiotic_resistance ARO:3005395 CAR beta-lactamase CDD beta-lactamases are class D beta-lactamases found in Clostridioides difficile. antibiotic_resistance ARO:3005396 CDD beta-lactamase CMA beta-lactamases are class C beta-lactamases found in Cronobacter malonaticus. antibiotic_resistance ARO:3005397 CMA beta-lactamase CRD3 beta-lactamases are class B3 beta-lactamases. antibiotic_resistance ARO:3005398 CRD3 beta-lactamase CRH beta-lactamases are class A beta-lactamases found in Chromobacterium haemolyticum. antibiotic_resistance ARO:3005399 CRH beta-lactamase CRP beta-lactamases are class A beta-lactamase found in Chromobacterium piscinae. antibiotic_resistance ARO:3005400 CRP beta-lactamase CSA beta-lactamases are class C beta-lactamases found in Cronobacter sakazakii. antibiotic_resistance ARO:3005401 CSA beta-lactamase CSP beta-lactamases are class A beta-lactamases found in Capnocytophaga sputigena. antibiotic_resistance ARO:3005402 CSP beta-lactamase CVI beta-lactamases are a class B2 beta-lactamase found in Chromobacterium violaceum. antibiotic_resistance ARO:3005403 CVI beta-lactamase DHT2 beta-lactamases are class B3 beta-lactamases. antibiotic_resistance ARO:3005404 DHT2 beta-lactamase EAM beta-lactamase are class B3 beta-lactamases found in Qipengyuania aquimaris. antibiotic_resistance ARO:3005405 EAM beta-lactamase EC beta-lactamases are class C beta-lactamases found in Escherichia coli. antibiotic_resistance ARO:3005406 EC beta-lactamase ECM beta-lactamases are class B3 beta-lactamases found in Qipengyuania citrea. antibiotic_resistance ARO:3005407 ECM beta-lactamase ECV beta-lactamases are class B1 beta-lactamases found in Echinicola vietnamensis. antibiotic_resistance ARO:3005408 ECV beta-lactamase EFM beta-lactamases are class B3 beta-lactamase found in Qipengyuania flava. antibiotic_resistance ARO:3005409 EFM beta-lactamase ELM beta-lactamases are class B3 beta-lactamases found in Erythrobacter longus. antibiotic_resistance ARO:3005410 ELM beta-lactamase EVM beta-lactamases are class B3 beta-lactamases found in Qipengyuania vulgaris. antibiotic_resistance ARO:3005411 EVM beta-lactamase FIA beta-lactamases are class B1 beta-lactamases found in Fibrella aestuarina. antibiotic_resistance ARO:3005412 FIA beta-lactamase GIL-beta-lactamases are class A beta-lactamases found in Citrobacter gillenii. antibiotic_resistance ARO:3005413 GIL beta-lactamase GMB beta-lactamases are class B1 beta-lactamases found in Citrobacter freundii. antibiotic_resistance ARO:3005414 GMB beta-lactamase GRD23 beta-lactamases are class B1 beta-lactamases. antibiotic_resistance ARO:3005415 GRD23 beta-lactamase GRD33 beta-lactamases are class B3 beta-lactamase. antibiotic_resistance ARO:3005416 GRD33 beta-lactamase KLUC beta-lactamases are class A beta-lactamases found in Kluyvera cryocrescens, Escherichia coli and Enterobacteriaceae. antibiotic_resistance ARO:3005417 KLUC beta-lactamase LHK beta-lactamases are class C beta-lactamases found in Laribacter hongkongensis. antibiotic_resistance ARO:3005418 LHK beta-lactamase LRG beta-lactamases are class A beta-lactamases. antibiotic_resistance ARO:3005419 LRG beta-lactamase LUS beta-lactamases are class A beta-lactamases found in Pedobacter lusitanus. antibiotic_resistance ARO:3005420 LUS beta-lactamase LUT beta-lactamases are class A beta lactamases found in Pseudomonas luteola. antibiotic_resistance ARO:3005421 LUT beta-lactamase MAL beta-lactamase are class A beta-lactamases found in Citrobacter koseri. antibiotic_resistance ARO:3005422 MAL beta-lactamase MBL beta-lactamases are class B3 beta-lactamases found in Caulobacter vibrioides. antibiotic_resistance ARO:3005423 MBL beta-lactamase MOC beta-lactamases are class B1 beta-lactamase found in Myroides odoratus. antibiotic_resistance ARO:3005424 MOC beta-lactamase MOR beta-lactamases are class C beta-lactamases found in Morganella morganii. antibiotic_resistance ARO:3005425 MOR beta-lactamase MYO beta-lactamases are class B1 beta-lactamases found in Myroides odoratimimus. antibiotic_resistance ARO:3005426 MYO beta-lactamase MYX beta-lactamases are class B1 beta-lactamases found in Myxococcus. antibiotic_resistance ARO:3005427 MYX beta-lactamase OHIO beta-lactamases are class A beta-lactamases. antibiotic_resistance ARO:3005428 OHIO beta-lactamase ORN beta-lactamases are class A beta-lactamases found in Raoultella ornithinolytica. antibiotic_resistance ARO:3005429 ORN beta-lactamase ORR beta-lactamases are class B1 beta-lactamases found in Ornithobacterium rhinotracheale. antibiotic_resistance ARO:3005430 ORR beta-lactamase PAU beta-lactamases are class A beta-lactamases found in Pseudomonas aeruginosa. antibiotic_resistance ARO:3005431 PAU beta-lactamase PFM beta-lactamases are class B2 beta-lactamases found in Pseudomonas fluorescens. antibiotic_resistance ARO:3005432 PFM beta-lactamase PLA beta-lactamases are class A beta-lactamase found in Raoultella planticola. antibiotic_resistance ARO:3005433 PLA beta-lactamase PLN beta-lactamases are class B3 beta-lactamases found in Pedobacter lusitanus. antibiotic_resistance ARO:3005434 PLN beta-lactamase PME beta-lactamases are class A beta-lactamases found in Gammaproteobacteria. antibiotic_resistance ARO:3005435 PME beta-lactamase POM beta-lactamases are class B3 beta-lactamases found in Pseudomonas otitidis. antibiotic_resistance ARO:3005436 POM beta-lactamase PST bea-lactamases are class B1 beta-lactamases found in Pseudomonas stutzeri. antibiotic_resistance ARO:3005437 PST beta-lactamase PSV beta-lactamases are class A beta-lactamases found in Pseudovibrio. antibiotic_resistance ARO:3005438 PSV beta-lactamase RAHN beta-lactamases are class A beta-lactamases found in Rahnella aquatilis. antibiotic_resistance ARO:3005439 RAHN beta-lactamase RSA2 beta-lactamases are class A beta-lactamases. antibiotic_resistance ARO:3005440 RSA2 beta-lactamase RSD2 beta-lactamases are class D beta-lactamases. antibiotic_resistance ARO:3005441 RSD2 beta-lactamase RUB beta-lactamases are class A beta-lactamases found in Serratia rubidaea. antibiotic_resistance ARO:3005442 RUB beta-lactamase SFC beta-lactamases are class A beta-lactamases found in Serratia fonticola. antibiotic_resistance ARO:3005443 SFC beta-lactamase SFO beta-lactamases are class A beta-lactamases found in Gammaproteobacteria. antibiotic_resistance ARO:3005444 SFO beta-lactamase SGM beta-lactamases are class A beta-lactamases found in members of the Sphingobium genus. antibiotic_resistance ARO:3005445 SGM beta-lactamase SHN beta-lactamases are class B1 beta-lactamases found in Shewanella denitrificans. antibiotic_resistance ARO:3005446 SHN beta-lactamase SPN beta-lactamases are class B1 beta-lactamases. antibiotic_resistance ARO:3005447 SPN79 beta-lactamase SPR beta-lactamases are class B beta-lactamases found in Serratia proteamaculans. antibiotic_resistance ARO:3005448 SPR beta-lactamase SPS beta-lactamases are class B1 beta lactamases found in Sediminispirochaeta smaragdinae. antibiotic_resistance ARO:3005449 SPS beta-lactamase SPU beta-lactamases are class A beta-lactamases found in Capnocytophaga sputigena. antibiotic_resistance ARO:3005450 SPU beta-lactamase SST beta-lactamases are class C beta-lactamases found in Serratia marcescens. antibiotic_resistance ARO:3005451 SST beta-lactamase STA beta-lactamases are class B1 beta-lactamases found in Stigmatella aurantiaca. antibiotic_resistance ARO:3005452 STA beta-lactamase TER beta-lactamases are class A beta-lactamases found in Raoultella terrigena. antibiotic_resistance ARO:3005453 TER beta-lactamase TTU beta-lactamases are class B1 beta-lactamases found in Teredinibacter turnerae. antibiotic_resistance ARO:3005454 TTU beta-lactamase VHH beta-lactamases are class A beta-lactamases found in Vibrio harveyi. antibiotic_resistance ARO:3005455 VHH beta-lactamase VHW beta-lactamases are class A beta-lactamases found Vibrio harveyi. antibiotic_resistance ARO:3005456 VHW beta-lactamase YEM beta-lactamases are class B2 beta-lactamases found in Yersinia mollaretii. antibiotic_resistance ARO:3005457 YEM beta-lactamase ZOG beta-lactamases are class B1 beta-lactamases found in Zobellia galactanivorans. antibiotic_resistance ARO:3005458 ZOG beta-lactamase ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins and may or may not cause resistance to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis. antibiotic_resistance ARO:3005459 ADC beta-lactamase ADC beta-lactamases with undetermined carbapenemase activity. antibiotic_resistance ARO:3005460 ADC beta-lactamases pending classification for carbapenemase activity EBR-3 is a EBR beta-lactamase. EBR-3 antibiotic_resistance ARO:3005461 EBR-3 EBR-3 EBR-4 is a EBR beta-lactamase. EBR-4 antibiotic_resistance ARO:3005462 EBR-4 EBR-4 IMP-53 is a IMP beta-lactamase. IMP-53 antibiotic_resistance ARO:3005463 IMP-53 IMP-53 IMP-54 is a IMP beta-lactamase. IMP-54 antibiotic_resistance ARO:3005464 IMP-54 IMP-54 IMP-58 is a IMP beta-lactamase. IMP-58 antibiotic_resistance ARO:3005465 IMP-58 IMP-58 IMP-59 is a IMP beta-lactamase. IMP-59 antibiotic_resistance ARO:3005466 IMP-59 IMP-59 IMP-60 is a IMP beta-lactamase. IMP-60 antibiotic_resistance ARO:3005467 IMP-60 IMP-60 IMP-61 is a IMP beta-lactamase. IMP-61 antibiotic_resistance ARO:3005468 IMP-61 IMP-61 IMP-62 is a IMP beta-lactamase. IMP-62 antibiotic_resistance ARO:3005469 IMP-62 IMP-62 IMP-63 is a IMP beta-lactamase. IMP-63 antibiotic_resistance ARO:3005470 IMP-63 IMP-63 IMP-64 is a IMP beta-lactamase. IMP-64 antibiotic_resistance ARO:3005471 IMP-64 IMP-64 IMP-65 is a IMP beta-lactamase. IMP-65 antibiotic_resistance ARO:3005472 IMP-65 IMP-65 IMP-66 is a IMP beta-lactamase. IMP-66 antibiotic_resistance ARO:3005473 IMP-66 IMP-66 IMP-67 is a IMP beta-lactamase. IMP-67 antibiotic_resistance ARO:3005474 IMP-67 IMP-67 IMP-69 is a IMP beta-lactamase. IMP-69 antibiotic_resistance ARO:3005475 IMP-69 IMP-69 IMP-70 is a IMP beta-lactamase. IMP-70 antibiotic_resistance ARO:3005476 IMP-70 IMP-70 IMP-71 is a IMP beta-lactamase. IMP-71 antibiotic_resistance ARO:3005477 IMP-71 IMP-71 IMP-73 is a IMP beta-lactamase. IMP-73 antibiotic_resistance ARO:3005478 IMP-73 IMP-73 IMP-74 is a IMP beta-lactamase. IMP-74 antibiotic_resistance ARO:3005479 IMP-74 IMP-74 IMP-75 is a IMP beta-lactamase. IMP-75 antibiotic_resistance ARO:3005480 IMP-75 IMP-75 IMP-76 is a IMP beta-lactamase. IMP-76 antibiotic_resistance ARO:3005481 IMP-76 IMP-76 IMP-77 is a IMP beta-lactamase. IMP-77 antibiotic_resistance ARO:3005482 IMP-77 IMP-77 IMP-78 is a IMP beta-lactamase. IMP-78 antibiotic_resistance ARO:3005483 IMP-78 IMP-78 IMP-79 is a IMP beta-lactamase. IMP-79 antibiotic_resistance ARO:3005484 IMP-79 IMP-79 IMP-80 is a IMP beta-lactamase. IMP-80 antibiotic_resistance ARO:3005485 IMP-80 IMP-80 IMP-81 is a IMP beta-lactamase. IMP-81 antibiotic_resistance ARO:3005486 IMP-81 IMP-81 IMP-82 is a IMP beta-lactamase. IMP-82 antibiotic_resistance ARO:3005487 IMP-82 IMP-82 IMP-83 is a IMP beta-lactamase. IMP-83 antibiotic_resistance ARO:3005488 IMP-83 IMP-83 IMP-84 is a IMP beta-lactamase. IMP-84 antibiotic_resistance ARO:3005489 IMP-84 IMP-84 IMP-85 is a IMP beta-lactamase. IMP-85 antibiotic_resistance ARO:3005490 IMP-85 IMP-85 IMP-88 is a IMP beta-lactamase. IMP-88 antibiotic_resistance ARO:3005491 IMP-88 IMP-88 IMP-89 is a IMP beta-lactamase. IMP-89 antibiotic_resistance ARO:3005492 IMP-89 IMP-89 IND-16 is a IND beta-lactamase. IND-16 antibiotic_resistance ARO:3005493 IND-16 IND-16 SIM-2 is a SIM beta-lactamase. SIM-2 antibiotic_resistance ARO:3005494 SIM-2 SIM-2 VIM-47 is a VIM beta-lactamase. VIM-47 antibiotic_resistance ARO:3005495 VIM-47 VIM-47 VIM-48 is a VIM beta-lactamase. VIM-48 antibiotic_resistance ARO:3005496 VIM-48 VIM-48 VIM-49 is a VIM beta-lactamase. VIM-49 antibiotic_resistance ARO:3005497 VIM-49 VIM-49 VIM-50 is a VIM beta-lactamase. VIM-50 antibiotic_resistance ARO:3005498 VIM-50 VIM-50 VIM-51 is a VIM beta-lactamase. VIM-51 antibiotic_resistance ARO:3005499 VIM-51 VIM-51 VIM-52 is a VIM beta-lactamase. VIM-52 antibiotic_resistance ARO:3005500 VIM-52 VIM-52 VIM-53 is a VIM beta-lactamase. VIM-53 antibiotic_resistance ARO:3005501 VIM-53 VIM-53 VIM-54 is a VIM beta-lactamase. VIM-54 antibiotic_resistance ARO:3005502 VIM-54 VIM-54 VIM-55 is a VIM beta-lactamase. VIM-55 antibiotic_resistance ARO:3005503 VIM-55 VIM-55 VIM-56 is a VIM beta-lactamase. VIM-56 antibiotic_resistance ARO:3005504 VIM-56 VIM-56 VIM-57 is a VIM beta-lactamase. VIM-57 antibiotic_resistance ARO:3005505 VIM-57 VIM-57 VIM-58 is a VIM beta-lactamase. VIM-58 antibiotic_resistance ARO:3005506 VIM-58 VIM-58 VIM-59 is a VIM beta-lactamase. VIM-59 antibiotic_resistance ARO:3005507 VIM-59 VIM-59 VIM-60 is a VIM beta-lactamase. VIM-60 antibiotic_resistance ARO:3005508 VIM-60 VIM-60 VIM-61 is a VIM beta-lactamase. VIM-61 antibiotic_resistance ARO:3005509 VIM-61 VIM-61 VIM-62 is a VIM beta-lactamase. VIM-62 antibiotic_resistance ARO:3005510 VIM-62 VIM-62 VIM-63 is a VIM beta-lactamase. VIM-63 antibiotic_resistance ARO:3005511 VIM-63 VIM-63 VIM-64 is a VIM beta-lactamase. VIM-64 antibiotic_resistance ARO:3005512 VIM-64 VIM-64 VIM-65 is a VIM beta-lactamase. VIM-65 antibiotic_resistance ARO:3005513 VIM-65 VIM-65 VIM-66 is a VIM beta-lactamase. VIM-66 antibiotic_resistance ARO:3005514 VIM-66 VIM-66 VIM-67 is a VIM beta-lactamase. VIM-67 antibiotic_resistance ARO:3005515 VIM-67 VIM-67 VIM-68 is a VIM beta-lactamase. VIM-68 antibiotic_resistance ARO:3005516 VIM-68 VIM-68 VIM-69 is a VIM beta-lactamase. VIM-69 antibiotic_resistance ARO:3005517 VIM-69 VIM-69 VIM-70 is a VIM beta-lactamase. VIM-70 antibiotic_resistance ARO:3005518 VIM-70 VIM-70 VIM-71 is a VIM beta-lactamase. VIM-71 antibiotic_resistance ARO:3005519 VIM-71 VIM-71 VIM-72 is a VIM beta-lactamase. VIM-72 antibiotic_resistance ARO:3005520 VIM-72 VIM-72 VIM-73 is a VIM beta-lactamase. VIM-73 antibiotic_resistance ARO:3005521 VIM-73 VIM-73 BlaB-1 is a BlaB beta-lactamase. BlaB-1 antibiotic_resistance ARO:3005522 BlaB-1 BlaB-1 BlaB-10 is a BlaB beta-lactamase. BlaB-10 antibiotic_resistance ARO:3005523 BlaB-10 BlaB-10 BlaB-11 is a BlaB beta-lactamase. BlaB-11 antibiotic_resistance ARO:3005524 BlaB-11 BlaB-11 BlaB-12 is a BlaB beta-lactamase. BlaB-12 antibiotic_resistance ARO:3005525 BlaB-12 BlaB-12 BlaB-13 is a BlaB beta-lactamase. BlaB-13 antibiotic_resistance ARO:3005526 BlaB-13 BlaB-13 BlaB-14 is a BlaB beta-lactamase. BlaB-14 antibiotic_resistance ARO:3005527 BlaB-14 BlaB-14 BlaB-15 is a BlaB beta-lactamase. BlaB-15 antibiotic_resistance ARO:3005528 BlaB-15 BlaB-15 BlaB-16 is a BlaB beta-lactamase. BlaB-16 antibiotic_resistance ARO:3005529 BlaB-16 BlaB-16 BlaB-17 is a BlaB beta-lactamase. BlaB-17 antibiotic_resistance ARO:3005530 BlaB-17 BlaB-17 BlaB-18 is a BlaB beta-lactamase. BlaB-18 antibiotic_resistance ARO:3005531 BlaB-18 BlaB-18 BlaB-19 is a BlaB beta-lactamase. BlaB-19 antibiotic_resistance ARO:3005532 BlaB-19 BlaB-19 BlaB-2 is a BlaB beta-lactamase. BlaB-2 antibiotic_resistance ARO:3005533 BlaB-2 BlaB-2 BlaB-20 is a BlaB beta-lactamase. BlaB-20 antibiotic_resistance ARO:3005534 BlaB-20 BlaB-20 BlaB-22 is a BlaB beta-lactamase. BlaB-22 antibiotic_resistance ARO:3005535 BlaB-22 BlaB-22 BlaB-23 is a BlaB beta-lactamase. BlaB-23 antibiotic_resistance ARO:3005536 BlaB-23 BlaB-23 BlaB-24 is a BlaB beta-lactamase. BlaB-24 antibiotic_resistance ARO:3005537 BlaB-24 BlaB-24 BlaB-25 is a BlaB beta-lactamase. BlaB-25 antibiotic_resistance ARO:3005538 BlaB-25 BlaB-25 BlaB-26 is a BlaB beta-lactamase. BlaB-26 antibiotic_resistance ARO:3005539 BlaB-26 BlaB-26 BlaB-27 is a BlaB beta-lactamase. BlaB-27 antibiotic_resistance ARO:3005540 BlaB-27 BlaB-27 BlaB-28 is a BlaB beta-lactamase. BlaB-28 antibiotic_resistance ARO:3005541 BlaB-28 BlaB-28 BlaB-29 is a BlaB beta-lactamase. BlaB-29 antibiotic_resistance ARO:3005542 BlaB-29 BlaB-29 BlaB-3 is a BlaB beta-lactamase. BlaB-3 antibiotic_resistance ARO:3005543 BlaB-3 BlaB-3 BlaB-30 is a BlaB beta-lactamase. BlaB-30 antibiotic_resistance ARO:3005544 BlaB-30 BlaB-30 BlaB-31 is a BlaB beta-lactamase. BlaB-31 antibiotic_resistance ARO:3005545 BlaB-31 BlaB-31 BlaB-32 is a BlaB beta-lactamase. BlaB-32 antibiotic_resistance ARO:3005546 BlaB-32 BlaB-32 BlaB-33 is a BlaB beta-lactamase. BlaB-33 antibiotic_resistance ARO:3005547 BlaB-33 BlaB-33 BlaB-34 is a BlaB beta-lactamase. BlaB-34 antibiotic_resistance ARO:3005548 BlaB-34 BlaB-34 BlaB-35 is a BlaB beta-lactamase. BlaB-35 antibiotic_resistance ARO:3005549 BlaB-35 BlaB-35 BlaB-36 is a BlaB beta-lactamase. BlaB-36 antibiotic_resistance ARO:3005550 BlaB-36 BlaB-36 BlaB-38 is a BlaB beta-lactamase. BlaB-38 antibiotic_resistance ARO:3005551 BlaB-38 BlaB-38 BlaB-39 is a BlaB beta-lactamase. BlaB-39 antibiotic_resistance ARO:3005552 BlaB-39 BlaB-39 BlaB-5 is a BlaB beta-lactamase. BlaB-5 antibiotic_resistance ARO:3005553 BlaB-5 BlaB-5 BlaB-6 is a BlaB beta-lactamase. BlaB-6 antibiotic_resistance ARO:3005554 BlaB-6 BlaB-6 BlaB-7 is a BlaB beta-lactamase. BlaB-7 antibiotic_resistance ARO:3005555 BlaB-7 BlaB-7 BlaB-8 is a BlaB beta-lactamase. BlaB-8 antibiotic_resistance ARO:3005556 BlaB-8 BlaB-8 BlaB-9 is a BlaB beta-lactamase. BlaB-9 antibiotic_resistance ARO:3005557 BlaB-9 BlaB-9 BUT-2 is a BUT beta-lactamase. BUT-2 antibiotic_resistance ARO:3005558 BUT-2 BUT-2 CARB-11 is a CARB beta-lactamase. CARB-11 antibiotic_resistance ARO:3005559 CARB-11 CARB-11 CARB-24 is a CARB beta-lactamase. CARB-24 antibiotic_resistance ARO:3005560 CARB-24 CARB-24 CARB-25 is a CARB beta-lactamase. CARB-25 antibiotic_resistance ARO:3005561 CARB-25 CARB-25 CARB-26 is a CARB beta-lactamase. CARB-26 antibiotic_resistance ARO:3005562 CARB-26 CARB-26 CARB-27 is a CARB beta-lactamase. CARB-27 antibiotic_resistance ARO:3005563 CARB-27 CARB-27 CARB-28 is a CARB beta-lactamase. CARB-28 antibiotic_resistance ARO:3005564 CARB-28 CARB-28 CARB-29 is a CARB beta-lactamase. CARB-29 antibiotic_resistance ARO:3005565 CARB-29 CARB-29 CARB-30 is a CARB beta-lactamase. CARB-30 antibiotic_resistance ARO:3005566 CARB-30 CARB-30 CARB-31 is a CARB beta-lactamase. CARB-31 antibiotic_resistance ARO:3005567 CARB-31 CARB-31 CARB-32 is a CARB beta-lactamase. CARB-32 antibiotic_resistance ARO:3005568 CARB-32 CARB-32 CARB-33 is a CARB beta-lactamase. CARB-33 antibiotic_resistance ARO:3005569 CARB-33 CARB-33 CARB-34 is a CARB beta-lactamase. CARB-34 antibiotic_resistance ARO:3005570 CARB-34 CARB-34 CARB-35 is a CARB beta-lactamase. CARB-35 antibiotic_resistance ARO:3005571 CARB-35 CARB-35 CARB-36 is a CARB beta-lactamase. CARB-36 antibiotic_resistance ARO:3005572 CARB-36 CARB-36 CARB-38 is a CARB beta-lactamase. CARB-38 antibiotic_resistance ARO:3005573 CARB-38 CARB-38 CARB-40 is a CARB beta-lactamase. CARB-40 antibiotic_resistance ARO:3005574 CARB-40 CARB-40 CARB-41 is a CARB beta-lactamase. CARB-41 antibiotic_resistance ARO:3005575 CARB-41 CARB-41 CARB-42 is a CARB beta-lactamase. CARB-42 antibiotic_resistance ARO:3005576 CARB-42 CARB-42 CARB-43 is a CARB beta-lactamase. CARB-43 antibiotic_resistance ARO:3005577 CARB-43 CARB-43 CARB-44 is a CARB beta-lactamase. CARB-44 antibiotic_resistance ARO:3005578 CARB-44 CARB-44 CARB-45 is a CARB beta-lactamase. CARB-45 antibiotic_resistance ARO:3005579 CARB-45 CARB-45 CARB-46 is a CARB beta-lactamase. CARB-46 antibiotic_resistance ARO:3005580 CARB-46 CARB-46 CARB-47 is a CARB beta-lactamase. CARB-47 antibiotic_resistance ARO:3005581 CARB-47 CARB-47 CARB-48 is a CARB beta-lactamase. CARB-48 antibiotic_resistance ARO:3005582 CARB-48 CARB-48 CARB-49 is a CARB beta-lactamase. CARB-49 antibiotic_resistance ARO:3005583 CARB-49 CARB-49 CARB-50 is a CARB beta-lactamase. CARB-50 antibiotic_resistance ARO:3005584 CARB-50 CARB-50 CARB-51 is a CARB beta-lactamase. CARB-51 antibiotic_resistance ARO:3005585 CARB-51 CARB-51 CARB-52 is a CARB beta-lactamase. CARB-52 antibiotic_resistance ARO:3005586 CARB-52 CARB-52 CARB-53 is a CARB beta-lactamase. CARB-53 antibiotic_resistance ARO:3005587 CARB-53 CARB-53 CARB-54 is a CARB beta-lactamase. CARB-54 antibiotic_resistance ARO:3005588 CARB-54 CARB-54 CARB-55 is a CARB beta-lactamase. CARB-55 antibiotic_resistance ARO:3005589 CARB-55 CARB-55 CTX-M-167 is a CTX-M beta-lactamase. CTX-M-167 antibiotic_resistance ARO:3005590 CTX-M-167 CTX-M-167 CTX-M-168 is a CTX-M beta-lactamase. CTX-M-168 antibiotic_resistance ARO:3005591 CTX-M-168 CTX-M-168 CTX-M-169 is a CTX-M beta-lactamase. CTX-M-169 antibiotic_resistance ARO:3005592 CTX-M-169 CTX-M-169 CTX-M-170 is a CTX-M beta-lactamase. CTX-M-170 antibiotic_resistance ARO:3005593 CTX-M-170 CTX-M-170 CTX-M-171 is a CTX-M beta-lactamase. CTX-M-171 antibiotic_resistance ARO:3005594 CTX-M-171 CTX-M-171 CTX-M-172 is a CTX-M beta-lactamase. CTX-M-172 antibiotic_resistance ARO:3005595 CTX-M-172 CTX-M-172 CTX-M-173 is a CTX-M beta-lactamase. CTX-M-173 antibiotic_resistance ARO:3005596 CTX-M-173 CTX-M-173 CTX-M-174 is a CTX-M beta-lactamase. CTX-M-174 antibiotic_resistance ARO:3005597 CTX-M-174 CTX-M-174 CTX-M-175 is a CTX-M beta-lactamase. CTX-M-175 antibiotic_resistance ARO:3005598 CTX-M-175 CTX-M-175 CTX-M-176 is a CTX-M beta-lactamase. CTX-M-176 antibiotic_resistance ARO:3005599 CTX-M-176 CTX-M-176 CTX-M-177 is a CTX-M beta-lactamase. CTX-M-177 antibiotic_resistance ARO:3005600 CTX-M-177 CTX-M-177 CTX-M-178 is a CTX-M beta-lactamase. CTX-M-178 antibiotic_resistance ARO:3005601 CTX-M-178 CTX-M-178 CTX-M-179 is a CTX-M beta-lactamase. CTX-M-179 antibiotic_resistance ARO:3005602 CTX-M-179 CTX-M-179 CTX-M-180 is a CTX-M beta-lactamase. CTX-M-180 antibiotic_resistance ARO:3005603 CTX-M-180 CTX-M-180 CTX-M-181 is a CTX-M beta-lactamase. CTX-M-181 antibiotic_resistance ARO:3005604 CTX-M-181 CTX-M-181 CTX-M-182 is a CTX-M beta-lactamase. CTX-M-182 antibiotic_resistance ARO:3005605 CTX-M-182 CTX-M-182 CTX-M-183 is a CTX-M beta-lactamase. CTX-M-183 antibiotic_resistance ARO:3005606 CTX-M-183 CTX-M-183 CTX-M-184 is a CTX-M beta-lactamase. CTX-M-184 antibiotic_resistance ARO:3005607 CTX-M-184 CTX-M-184 CTX-M-185 is a CTX-M beta-lactamase. CTX-M-185 antibiotic_resistance ARO:3005608 CTX-M-185 CTX-M-185 CTX-M-186 is a CTX-M beta-lactamase. CTX-M-186 antibiotic_resistance ARO:3005609 CTX-M-186 CTX-M-186 CTX-M-187 is a CTX-M beta-lactamase. CTX-M-187 antibiotic_resistance ARO:3005610 CTX-M-187 CTX-M-187 CTX-M-188 is a CTX-M beta-lactamase. CTX-M-188 antibiotic_resistance ARO:3005611 CTX-M-188 CTX-M-188 CTX-M-189 is a CTX-M beta-lactamase. CTX-M-189 antibiotic_resistance ARO:3005612 CTX-M-189 CTX-M-189 CTX-M-190 is a CTX-M beta-lactamase. CTX-M-190 antibiotic_resistance ARO:3005613 CTX-M-190 CTX-M-190 CTX-M-191 is a CTX-M beta-lactamase. CTX-M-191 antibiotic_resistance ARO:3005614 CTX-M-191 CTX-M-191 CTX-M-192 is a CTX-M beta-lactamase. CTX-M-192 antibiotic_resistance ARO:3005615 CTX-M-192 CTX-M-192 CTX-M-193 is a CTX-M beta-lactamase. CTX-M-193 antibiotic_resistance ARO:3005616 CTX-M-193 CTX-M-193 CTX-M-194 is a CTX-M beta-lactamase. CTX-M-194 antibiotic_resistance ARO:3005617 CTX-M-194 CTX-M-194 CTX-M-195 is a CTX-M beta-lactamase. CTX-M-195 antibiotic_resistance ARO:3005618 CTX-M-195 CTX-M-195 CTX-M-196 is a CTX-M beta-lactamase. CTX-M-196 antibiotic_resistance ARO:3005619 CTX-M-196 CTX-M-196 CTX-M-197 is a CTX-M beta-lactamase. CTX-M-197 antibiotic_resistance ARO:3005620 CTX-M-197 CTX-M-197 CTX-M-198 is a CTX-M beta-lactamase. CTX-M-198 antibiotic_resistance ARO:3005621 CTX-M-198 CTX-M-198 CTX-M-199 is a CTX-M beta-lactamase. CTX-M-199 antibiotic_resistance ARO:3005622 CTX-M-199 CTX-M-199 CTX-M-200 is a CTX-M beta-lactamase. CTX-M-200 antibiotic_resistance ARO:3005623 CTX-M-200 CTX-M-200 CTX-M-201 is a CTX-M beta-lactamase. CTX-M-201 antibiotic_resistance ARO:3005624 CTX-M-201 CTX-M-201 CTX-M-202 is a CTX-M beta-lactamase. CTX-M-202 antibiotic_resistance ARO:3005625 CTX-M-202 CTX-M-202 CTX-M-203 is a CTX-M beta-lactamase. CTX-M-203 antibiotic_resistance ARO:3005626 CTX-M-203 CTX-M-203 CTX-M-204 is a CTX-M beta-lactamase. CTX-M-204 antibiotic_resistance ARO:3005627 CTX-M-204 CTX-M-204 CTX-M-205 is a CTX-M beta-lactamase. CTX-M-205 antibiotic_resistance ARO:3005628 CTX-M-205 CTX-M-205 CTX-M-206 is a CTX-M beta-lactamase. CTX-M-206 antibiotic_resistance ARO:3005629 CTX-M-206 CTX-M-206 CTX-M-207 is a CTX-M beta-lactamase. CTX-M-207 antibiotic_resistance ARO:3005630 CTX-M-207 CTX-M-207 CTX-M-208 is a CTX-M beta-lactamase. CTX-M-208 antibiotic_resistance ARO:3005631 CTX-M-208 CTX-M-208 CTX-M-209 is a CTX-M beta-lactamase. CTX-M-209 antibiotic_resistance ARO:3005632 CTX-M-209 CTX-M-209 CTX-M-210 is a CTX-M beta-lactamase. CTX-M-210 antibiotic_resistance ARO:3005633 CTX-M-210 CTX-M-210 CTX-M-211 is a CTX-M beta-lactamase. CTX-M-211 antibiotic_resistance ARO:3005634 CTX-M-211 CTX-M-211 CTX-M-212 is a CTX-M beta-lactamase. CTX-M-212 antibiotic_resistance ARO:3005635 CTX-M-212 CTX-M-212 CTX-M-213 is a CTX-M beta-lactamase. CTX-M-213 antibiotic_resistance ARO:3005636 CTX-M-213 CTX-M-213 CTX-M-214 is a CTX-M beta-lactamase. CTX-M-214 antibiotic_resistance ARO:3005637 CTX-M-214 CTX-M-214 CTX-M-215 is a CTX-M beta-lactamase. CTX-M-215 antibiotic_resistance ARO:3005638 CTX-M-215 CTX-M-215 CTX-M-216 is a CTX-M beta-lactamase. CTX-M-216 antibiotic_resistance ARO:3005639 CTX-M-216 CTX-M-216 CTX-M-217 is a CTX-M beta-lactamase. CTX-M-217 antibiotic_resistance ARO:3005640 CTX-M-217 CTX-M-217 CTX-M-218 is a CTX-M beta-lactamase. CTX-M-218 antibiotic_resistance ARO:3005641 CTX-M-218 CTX-M-218 CTX-M-219 is a CTX-M beta-lactamase. CTX-M-219 antibiotic_resistance ARO:3005642 CTX-M-219 CTX-M-219 CTX-M-220 is a CTX-M beta-lactamase. CTX-M-220 antibiotic_resistance ARO:3005643 CTX-M-220 CTX-M-220 CTX-M-221 is a CTX-M beta-lactamase. CTX-M-221 antibiotic_resistance ARO:3005644 CTX-M-221 CTX-M-221 CTX-M-222 is a CTX-M beta-lactamase. CTX-M-222 antibiotic_resistance ARO:3005645 CTX-M-222 CTX-M-222 CTX-M-223 is a CTX-M beta-lactamase. CTX-M-223 antibiotic_resistance ARO:3005646 CTX-M-223 CTX-M-223 CTX-M-224 is a CTX-M beta-lactamase. CTX-M-224 antibiotic_resistance ARO:3005647 CTX-M-224 CTX-M-224 CTX-M-225 is a CTX-M beta-lactamase. CTX-M-225 antibiotic_resistance ARO:3005648 CTX-M-225 CTX-M-225 CTX-M-226 is a CTX-M beta-lactamase. CTX-M-226 antibiotic_resistance ARO:3005649 CTX-M-226 CTX-M-226 CTX-M-227 is a CTX-M beta-lactamase. CTX-M-227 antibiotic_resistance ARO:3005650 CTX-M-227 CTX-M-227 CTX-M-228 is a CTX-M beta-lactamase. CTX-M-228 antibiotic_resistance ARO:3005651 CTX-M-228 CTX-M-228 CTX-M-229 is a CTX-M beta-lactamase. CTX-M-229 antibiotic_resistance ARO:3005652 CTX-M-229 CTX-M-229 CTX-M-230 is a CTX-M beta-lactamase. CTX-M-230 antibiotic_resistance ARO:3005653 CTX-M-230 CTX-M-230 CTX-M-231 is a CTX-M beta-lactamase. CTX-M-231 antibiotic_resistance ARO:3005654 CTX-M-231 CTX-M-231 CTX-M-232 is a CTX-M beta-lactamase. CTX-M-232 antibiotic_resistance ARO:3005655 CTX-M-232 CTX-M-232 CTX-M-233 is a CTX-M beta-lactamase. CTX-M-233 antibiotic_resistance ARO:3005656 CTX-M-233 CTX-M-233 CTX-M-234 is a CTX-M beta-lactamase. CTX-M-234 antibiotic_resistance ARO:3005657 CTX-M-234 CTX-M-234 CTX-M-235 is a CTX-M beta-lactamase. CTX-M-235 antibiotic_resistance ARO:3005658 CTX-M-235 CTX-M-235 CTX-M-236 is a CTX-M beta-lactamase. CTX-M-236 antibiotic_resistance ARO:3005659 CTX-M-236 CTX-M-236 CTX-M-237 is a CTX-M beta-lactamase. CTX-M-237 antibiotic_resistance ARO:3005660 CTX-M-237 CTX-M-237 CTX-M-238 is a CTX-M beta-lactamase. CTX-M-238 antibiotic_resistance ARO:3005661 CTX-M-238 CTX-M-238 CTX-M-239 is a CTX-M beta-lactamase. CTX-M-239 antibiotic_resistance ARO:3005662 CTX-M-239 CTX-M-239 CTX-M-240 is a CTX-M beta-lactamase. CTX-M-240 antibiotic_resistance ARO:3005663 CTX-M-240 CTX-M-240 CTX-M-241 is a CTX-M beta-lactamase. CTX-M-241 antibiotic_resistance ARO:3005664 CTX-M-241 CTX-M-241 CTX-M-242 is a CTX-M beta-lactamase. CTX-M-242 antibiotic_resistance ARO:3005665 CTX-M-242 CTX-M-242 CTX-M-244 is a CTX-M beta-lactamase. CTX-M-244 antibiotic_resistance ARO:3005666 CTX-M-244 CTX-M-244 CTX-M-97 is a CTX-M beta-lactamase. CTX-M-97 antibiotic_resistance ARO:3005667 CTX-M-97 CTX-M-97 GOB-19 is a GOB beta-lactamase. GOB-19 antibiotic_resistance ARO:3005668 GOB-19 GOB-19 GOB-20 is a GOB beta-lactamase. GOB-20 antibiotic_resistance ARO:3005669 GOB-20 GOB-20 GOB-21 is a GOB beta-lactamase. GOB-21 antibiotic_resistance ARO:3005670 GOB-21 GOB-21 GOB-22 is a GOB beta-lactamase. GOB-22 antibiotic_resistance ARO:3005671 GOB-22 GOB-22 GOB-23 is a GOB beta-lactamase. GOB-23 antibiotic_resistance ARO:3005672 GOB-23 GOB-23 GOB-24 is a GOB beta-lactamase. GOB-24 antibiotic_resistance ARO:3005673 GOB-24 GOB-24 GOB-25 is a GOB beta-lactamase. GOB-25 antibiotic_resistance ARO:3005674 GOB-25 GOB-25 GOB-26 is a GOB beta-lactamase. GOB-26 antibiotic_resistance ARO:3005675 GOB-26 GOB-26 GOB-27 is a GOB beta-lactamase. GOB-27 antibiotic_resistance ARO:3005676 GOB-27 GOB-27 GOB-28 is a GOB beta-lactamase. GOB-28 antibiotic_resistance ARO:3005677 GOB-28 GOB-28 GOB-29 is a GOB beta-lactamase. GOB-29 antibiotic_resistance ARO:3005678 GOB-29 GOB-29 GOB-30 is a GOB beta-lactamase. GOB-30 antibiotic_resistance ARO:3005679 GOB-30 GOB-30 GOB-31 is a GOB beta-lactamase. GOB-31 antibiotic_resistance ARO:3005680 GOB-31 GOB-31 GOB-32 is a GOB beta-lactamase. GOB-32 antibiotic_resistance ARO:3005681 GOB-32 GOB-32 GOB-33 is a GOB beta-lactamase. GOB-33 antibiotic_resistance ARO:3005682 GOB-33 GOB-33 GOB-34 is a GOB beta-lactamase. GOB-34 antibiotic_resistance ARO:3005683 GOB-34 GOB-34 GOB-35 is a GOB beta-lactamase. GOB-35 antibiotic_resistance ARO:3005684 GOB-35 GOB-35 GOB-36 is a GOB beta-lactamase. GOB-36 antibiotic_resistance ARO:3005685 GOB-36 GOB-36 GOB-37 is a GOB beta-lactamase. GOB-37 antibiotic_resistance ARO:3005686 GOB-37 GOB-37 GOB-38 is a GOB beta-lactamase. GOB-38 antibiotic_resistance ARO:3005687 GOB-38 GOB-38 GOB-39 is a GOB beta-lactamase. GOB-39 antibiotic_resistance ARO:3005688 GOB-39 GOB-39 GOB-40 is a GOB beta-lactamase. GOB-40 antibiotic_resistance ARO:3005689 GOB-40 GOB-40 GOB-41 is a GOB beta-lactamase. GOB-41 antibiotic_resistance ARO:3005690 GOB-41 GOB-41 GOB-42 is a GOB beta-lactamase. GOB-42 antibiotic_resistance ARO:3005691 GOB-42 GOB-42 GOB-43 is a GOB beta-lactamase. GOB-43 antibiotic_resistance ARO:3005692 GOB-43 GOB-43 GOB-44 is a GOB beta-lactamase. GOB-44 antibiotic_resistance ARO:3005693 GOB-44 GOB-44 GOB-45 is a GOB beta-lactamase. GOB-45 antibiotic_resistance ARO:3005694 GOB-45 GOB-45 GOB-46 is a GOB beta-lactamase. GOB-46 antibiotic_resistance ARO:3005695 GOB-46 GOB-46 GOB-48 is a GOB beta-lactamase. GOB-48 antibiotic_resistance ARO:3005696 GOB-48 GOB-48 GOB-49 is a GOB beta-lactamase. GOB-49 antibiotic_resistance ARO:3005697 GOB-49 GOB-49 GOB-50 is a GOB beta-lactamase. GOB-50 antibiotic_resistance ARO:3005698 GOB-50 GOB-50 GOB-51 is a GOB beta-lactamase. GOB-51 antibiotic_resistance ARO:3005699 GOB-51 GOB-51 NDM-30 is a NDM beta-lactamase. NDM-30 antibiotic_resistance ARO:3005700 NDM-30 NDM-30 NDM-31 is a NDM beta-lactamase. NDM-31 antibiotic_resistance ARO:3005701 NDM-31 NDM-31 OXA-114b is a OXA beta-lactamase. OXA-114b antibiotic_resistance ARO:3005702 OXA-114b OXA-114b OXA-114c is a OXA beta-lactamase. OXA-114c antibiotic_resistance ARO:3005703 OXA-114c OXA-114c OXA-114d is a OXA beta-lactamase. OXA-114d antibiotic_resistance ARO:3005704 OXA-114d OXA-114d OXA-114e is a OXA beta-lactamase. OXA-114e antibiotic_resistance ARO:3005705 OXA-114e OXA-114e OXA-114f is a OXA beta-lactamase. OXA-114f antibiotic_resistance ARO:3005706 OXA-114f OXA-114f OXA-114g is a OXA beta-lactamase. OXA-114g antibiotic_resistance ARO:3005707 OXA-114g OXA-114g OXA-114h is a OXA beta-lactamase. OXA-114h antibiotic_resistance ARO:3005708 OXA-114h OXA-114h OXA-114i is a OXA beta-lactamase. OXA-114i antibiotic_resistance ARO:3005709 OXA-114i OXA-114i OXA-114j is a OXA beta-lactamase. OXA-114j antibiotic_resistance ARO:3005710 OXA-114j OXA-114j OXA-114k is a OXA beta-lactamase. OXA-114k antibiotic_resistance ARO:3005711 OXA-114k OXA-114k OXA-114l is a OXA beta-lactamase. OXA-114l antibiotic_resistance ARO:3005712 OXA-114l OXA-114l OXA-114m is a OXA beta-lactamase. OXA-114m antibiotic_resistance ARO:3005713 OXA-114m OXA-114m OXA-114n is a OXA beta-lactamase. OXA-114n antibiotic_resistance ARO:3005714 OXA-114n OXA-114n OXA-114p is a OXA beta-lactamase. OXA-114p antibiotic_resistance ARO:3005715 OXA-114p OXA-114p OXA-114q is a OXA beta-lactamase. OXA-114q antibiotic_resistance ARO:3005716 OXA-114q OXA-114q OXA-114r is a OXA beta-lactamase. OXA-114r antibiotic_resistance ARO:3005717 OXA-114r OXA-114r OXA-114s is a OXA beta-lactamase. OXA-114s antibiotic_resistance ARO:3005718 OXA-114s OXA-114s OXA-114t is a OXA beta-lactamase. OXA-114t antibiotic_resistance ARO:3005719 OXA-114t OXA-114t OXA-114u is a OXA beta-lactamase. OXA-114u antibiotic_resistance ARO:3005720 OXA-114u OXA-114u OXA-114v is a OXA beta-lactamase. OXA-114v antibiotic_resistance ARO:3005721 OXA-114v OXA-114v OXA-114w is a OXA beta-lactamase. OXA-114w antibiotic_resistance ARO:3005722 OXA-114w OXA-114w OXA-114x is a OXA beta-lactamase. OXA-114x antibiotic_resistance ARO:3005723 OXA-114x OXA-114x OXA-489 is a OXA beta-lactamase. OXA-489 antibiotic_resistance ARO:3005724 OXA-489 OXA-489 OXA-491 is a OXA beta-lactamase. OXA-491 antibiotic_resistance ARO:3005725 OXA-491 OXA-491 OXA-493 is a OXA beta-lactamase. OXA-493 antibiotic_resistance ARO:3005726 OXA-493 OXA-493 OXA-494 is a OXA beta-lactamase. OXA-494 antibiotic_resistance ARO:3005727 OXA-494 OXA-494 OXA-497 is a OXA beta-lactamase. OXA-497 antibiotic_resistance ARO:3005728 OXA-497 OXA-497 OXA-498 is a OXA beta-lactamase. OXA-498 antibiotic_resistance ARO:3005729 OXA-498 OXA-498 OXA-500 is a OXA beta-lactamase. OXA-500 antibiotic_resistance ARO:3005730 OXA-500 OXA-500 OXA-501 is a OXA beta-lactamase. OXA-501 antibiotic_resistance ARO:3005731 OXA-501 OXA-501 OXA-502 is a OXA beta-lactamase. OXA-502 antibiotic_resistance ARO:3005732 OXA-502 OXA-502 OXA-503 is a OXA beta-lactamase. OXA-503 antibiotic_resistance ARO:3005733 OXA-503 OXA-503 OXA-504 is a OXA beta-lactamase. OXA-504 antibiotic_resistance ARO:3005734 OXA-504 OXA-504 OXA-505 is a OXA beta-lactamase. OXA-505 antibiotic_resistance ARO:3005735 OXA-505 OXA-505 OXA-506 is a OXA beta-lactamase. OXA-506 antibiotic_resistance ARO:3005736 OXA-506 OXA-506 OXA-507 is a OXA beta-lactamase. OXA-507 antibiotic_resistance ARO:3005737 OXA-507 OXA-507 OXA-508 is a OXA beta-lactamase. OXA-508 antibiotic_resistance ARO:3005738 OXA-508 OXA-508 OXA-509 is a OXA beta-lactamase. OXA-509 antibiotic_resistance ARO:3005739 OXA-509 OXA-509 OXA-510 is a OXA beta-lactamase. OXA-510 antibiotic_resistance ARO:3005740 OXA-510 OXA-510 OXA-511 is a OXA beta-lactamase. OXA-511 antibiotic_resistance ARO:3005741 OXA-511 OXA-511 OXA-512 is a OXA beta-lactamase. OXA-512 antibiotic_resistance ARO:3005742 OXA-512 OXA-512 OXA-513 is a OXA beta-lactamase. OXA-513 antibiotic_resistance ARO:3005743 OXA-513 OXA-513 OXA-514 is a OXA beta-lactamase. OXA-514 antibiotic_resistance ARO:3005744 OXA-514 OXA-514 OXA-515 is a OXA beta-lactamase. OXA-515 antibiotic_resistance ARO:3005745 OXA-515 OXA-515 OXA-516 is a OXA beta-lactamase. OXA-516 antibiotic_resistance ARO:3005746 OXA-516 OXA-516 OXA-517 is a OXA beta-lactamase. OXA-517 antibiotic_resistance ARO:3005747 OXA-517 OXA-517 OXA-518 is a OXA beta-lactamase. OXA-518 antibiotic_resistance ARO:3005748 OXA-518 OXA-518 OXA-519 is a OXA beta-lactamase. OXA-519 antibiotic_resistance ARO:3005749 OXA-519 OXA-519 OXA-520 is a OXA beta-lactamase. OXA-520 antibiotic_resistance ARO:3005750 OXA-520 OXA-520 OXA-521 is a OXA beta-lactamase. OXA-521 antibiotic_resistance ARO:3005751 OXA-521 OXA-521 OXA-522 is a OXA beta-lactamase. OXA-522 antibiotic_resistance ARO:3005752 OXA-522 OXA-522 OXA-523 is a OXA beta-lactamase. OXA-523 antibiotic_resistance ARO:3005753 OXA-523 OXA-523 OXA-524 is a OXA beta-lactamase. OXA-524 antibiotic_resistance ARO:3005754 OXA-524 OXA-524 OXA-525 is a OXA beta-lactamase. OXA-525 antibiotic_resistance ARO:3005755 OXA-525 OXA-525 OXA-526 is a OXA beta-lactamase. OXA-526 antibiotic_resistance ARO:3005756 OXA-526 OXA-526 OXA-527 is a OXA beta-lactamase. OXA-527 antibiotic_resistance ARO:3005757 OXA-527 OXA-527 OXA-528 is a OXA beta-lactamase. OXA-528 antibiotic_resistance ARO:3005758 OXA-528 OXA-528 OXA-529 is a OXA beta-lactamase. OXA-529 antibiotic_resistance ARO:3005759 OXA-529 OXA-529 OXA-530 is a OXA beta-lactamase. OXA-530 antibiotic_resistance ARO:3005760 OXA-530 OXA-530 OXA-531 is a OXA beta-lactamase. OXA-531 antibiotic_resistance ARO:3005761 OXA-531 OXA-531 OXA-532 is a OXA beta-lactamase. OXA-532 antibiotic_resistance ARO:3005762 OXA-532 OXA-532 OXA-533 is a OXA beta-lactamase. OXA-533 antibiotic_resistance ARO:3005763 OXA-533 OXA-533 OXA-534 is a OXA beta-lactamase. OXA-534 antibiotic_resistance ARO:3005764 OXA-534 OXA-534 OXA-536 is a OXA beta-lactamase. OXA-536 antibiotic_resistance ARO:3005765 OXA-536 OXA-536 OXA-537 is a OXA beta-lactamase. OXA-537 antibiotic_resistance ARO:3005766 OXA-537 OXA-537 OXA-538 is a OXA beta-lactamase. OXA-538 antibiotic_resistance ARO:3005767 OXA-538 OXA-538 OXA-542 is a OXA beta-lactamase. OXA-542 antibiotic_resistance ARO:3005768 OXA-542 OXA-542 OXA-545 is a OXA beta-lactamase. OXA-545 antibiotic_resistance ARO:3005769 OXA-545 OXA-545 OXA-546 is a OXA beta-lactamase. OXA-546 antibiotic_resistance ARO:3005770 OXA-546 OXA-546 OXA-547 is a OXA beta-lactamase. OXA-547 antibiotic_resistance ARO:3005771 OXA-547 OXA-547 OXA-548 is a OXA beta-lactamase. OXA-548 antibiotic_resistance ARO:3005772 OXA-548 OXA-548 OXA-549 is a OXA beta-lactamase. OXA-549 antibiotic_resistance ARO:3005773 OXA-549 OXA-549 OXA-550 is a OXA beta-lactamase. OXA-550 antibiotic_resistance ARO:3005774 OXA-550 OXA-550 OXA-551 is a OXA beta-lactamase. OXA-551 antibiotic_resistance ARO:3005775 OXA-551 OXA-551 OXA-552 is a OXA beta-lactamase. OXA-552 antibiotic_resistance ARO:3005776 OXA-552 OXA-552 OXA-553 is a OXA beta-lactamase. OXA-553 antibiotic_resistance ARO:3005777 OXA-553 OXA-553 OXA-554 is a OXA beta-lactamase. OXA-554 antibiotic_resistance ARO:3005778 OXA-554 OXA-554 OXA-555 is a OXA beta-lactamase. OXA-555 antibiotic_resistance ARO:3005779 OXA-555 OXA-555 OXA-556 is a OXA beta-lactamase. OXA-556 antibiotic_resistance ARO:3005780 OXA-556 OXA-556 OXA-557 is a OXA beta-lactamase. OXA-557 antibiotic_resistance ARO:3005781 OXA-557 OXA-557 OXA-558 is a OXA beta-lactamase. OXA-558 antibiotic_resistance ARO:3005782 OXA-558 OXA-558 OXA-559 is a OXA beta-lactamase. OXA-559 antibiotic_resistance ARO:3005783 OXA-559 OXA-559 OXA-560 is a OXA beta-lactamase. OXA-560 antibiotic_resistance ARO:3005784 OXA-560 OXA-560 OXA-561 is a OXA beta-lactamase. OXA-561 antibiotic_resistance ARO:3005785 OXA-561 OXA-561 OXA-562 is a OXA beta-lactamase. OXA-562 antibiotic_resistance ARO:3005786 OXA-562 OXA-562 OXA-563 is a OXA beta-lactamase. OXA-563 antibiotic_resistance ARO:3005787 OXA-563 OXA-563 OXA-564 is a OXA beta-lactamase. OXA-564 antibiotic_resistance ARO:3005788 OXA-564 OXA-564 OXA-565 is a OXA beta-lactamase. OXA-565 antibiotic_resistance ARO:3005789 OXA-565 OXA-565 OXA-566 is a OXA beta-lactamase. OXA-566 antibiotic_resistance ARO:3005790 OXA-566 OXA-566 OXA-567 is a OXA beta-lactamase. OXA-567 antibiotic_resistance ARO:3005791 OXA-567 OXA-567 OXA-568 is a OXA beta-lactamase. OXA-568 antibiotic_resistance ARO:3005792 OXA-568 OXA-568 OXA-569 is a OXA beta-lactamase. OXA-569 antibiotic_resistance ARO:3005793 OXA-569 OXA-569 OXA-572 is a OXA beta-lactamase. OXA-572 antibiotic_resistance ARO:3005794 OXA-572 OXA-572 OXA-574 is a OXA beta-lactamase. OXA-574 antibiotic_resistance ARO:3005795 OXA-574 OXA-574 OXA-575 is a OXA beta-lactamase. OXA-575 antibiotic_resistance ARO:3005796 OXA-575 OXA-575 OXA-576 is a OXA beta-lactamase. OXA-576 antibiotic_resistance ARO:3005797 OXA-576 OXA-576 OXA-577 is a OXA beta-lactamase. OXA-577 antibiotic_resistance ARO:3005798 OXA-577 OXA-577 OXA-578 is a OXA beta-lactamase. OXA-578 antibiotic_resistance ARO:3005799 OXA-578 OXA-578 OXA-579 is a OXA beta-lactamase. OXA-579 antibiotic_resistance ARO:3005800 OXA-579 OXA-579 OXA-580 is a OXA beta-lactamase. OXA-580 antibiotic_resistance ARO:3005801 OXA-580 OXA-580 OXA-581 is a OXA beta-lactamase. OXA-581 antibiotic_resistance ARO:3005802 OXA-581 OXA-581 OXA-582 is a OXA beta-lactamase. OXA-582 antibiotic_resistance ARO:3005803 OXA-582 OXA-582 OXA-583 is a OXA beta-lactamase. OXA-583 antibiotic_resistance ARO:3005804 OXA-583 OXA-583 OXA-584 is a OXA beta-lactamase. OXA-584 antibiotic_resistance ARO:3005805 OXA-584 OXA-584 OXA-585 is a OXA beta-lactamase. OXA-585 antibiotic_resistance ARO:3005806 OXA-585 OXA-585 OXA-586 is a OXA beta-lactamase. OXA-586 antibiotic_resistance ARO:3005807 OXA-586 OXA-586 OXA-587 is a OXA beta-lactamase. OXA-587 antibiotic_resistance ARO:3005808 OXA-587 OXA-587 OXA-588 is a OXA beta-lactamase. OXA-588 antibiotic_resistance ARO:3005809 OXA-588 OXA-588 OXA-589 is a OXA beta-lactamase. OXA-589 antibiotic_resistance ARO:3005810 OXA-589 OXA-589 OXA-590 is a OXA beta-lactamase. OXA-590 antibiotic_resistance ARO:3005811 OXA-590 OXA-590 OXA-591 is a OXA beta-lactamase. OXA-591 antibiotic_resistance ARO:3005812 OXA-591 OXA-591 OXA-592 is a OXA beta-lactamase. OXA-592 antibiotic_resistance ARO:3005813 OXA-592 OXA-592 OXA-593 is a OXA beta-lactamase. OXA-593 antibiotic_resistance ARO:3005814 OXA-593 OXA-593 OXA-594 is a OXA beta-lactamase. OXA-594 antibiotic_resistance ARO:3005815 OXA-594 OXA-594 OXA-595 is a OXA beta-lactamase. OXA-595 antibiotic_resistance ARO:3005816 OXA-595 OXA-595 OXA-596 is a OXA beta-lactamase. OXA-596 antibiotic_resistance ARO:3005817 OXA-596 OXA-596 OXA-597 is a OXA beta-lactamase. OXA-597 antibiotic_resistance ARO:3005818 OXA-597 OXA-597 OXA-598 is a OXA beta-lactamase. OXA-598 antibiotic_resistance ARO:3005819 OXA-598 OXA-598 OXA-599 is a OXA beta-lactamase. OXA-599 antibiotic_resistance ARO:3005820 OXA-599 OXA-599 OXA-600 is a OXA beta-lactamase. OXA-600 antibiotic_resistance ARO:3005821 OXA-600 OXA-600 OXA-601 is a OXA beta-lactamase. OXA-601 antibiotic_resistance ARO:3005822 OXA-601 OXA-601 OXA-602 is a OXA beta-lactamase. OXA-602 antibiotic_resistance ARO:3005823 OXA-602 OXA-602 OXA-603 is a OXA beta-lactamase. OXA-603 antibiotic_resistance ARO:3005824 OXA-603 OXA-603 OXA-604 is a OXA beta-lactamase. OXA-604 antibiotic_resistance ARO:3005825 OXA-604 OXA-604 OXA-605 is a OXA beta-lactamase. OXA-605 antibiotic_resistance ARO:3005826 OXA-605 OXA-605 OXA-606 is a OXA beta-lactamase. OXA-606 antibiotic_resistance ARO:3005827 OXA-606 OXA-606 OXA-607 is a OXA beta-lactamase. OXA-607 antibiotic_resistance ARO:3005828 OXA-607 OXA-607 OXA-608 is a OXA beta-lactamase. OXA-608 antibiotic_resistance ARO:3005829 OXA-608 OXA-608 OXA-609 is a OXA beta-lactamase. OXA-609 antibiotic_resistance ARO:3005830 OXA-609 OXA-609 OXA-610 is a OXA beta-lactamase. OXA-610 antibiotic_resistance ARO:3005831 OXA-610 OXA-610 OXA-611 is a OXA beta-lactamase. OXA-611 antibiotic_resistance ARO:3005832 OXA-611 OXA-611 OXA-612 is a OXA beta-lactamase. OXA-612 antibiotic_resistance ARO:3005833 OXA-612 OXA-612 OXA-613 is a OXA beta-lactamase. OXA-613 antibiotic_resistance ARO:3005834 OXA-613 OXA-613 OXA-614 is a OXA beta-lactamase. OXA-614 antibiotic_resistance ARO:3005835 OXA-614 OXA-614 OXA-615 is a OXA beta-lactamase. OXA-615 antibiotic_resistance ARO:3005836 OXA-615 OXA-615 OXA-616 is a OXA beta-lactamase. OXA-616 antibiotic_resistance ARO:3005837 OXA-616 OXA-616 OXA-617 is a OXA beta-lactamase. OXA-617 antibiotic_resistance ARO:3005838 OXA-617 OXA-617 OXA-618 is a OXA beta-lactamase. OXA-618 antibiotic_resistance ARO:3005839 OXA-618 OXA-618 OXA-619 is a OXA beta-lactamase. OXA-619 antibiotic_resistance ARO:3005840 OXA-619 OXA-619 OXA-620 is a OXA beta-lactamase. OXA-620 antibiotic_resistance ARO:3005841 OXA-620 OXA-620 OXA-621 is a OXA beta-lactamase. OXA-621 antibiotic_resistance ARO:3005842 OXA-621 OXA-621 OXA-622 is a OXA beta-lactamase. OXA-622 antibiotic_resistance ARO:3005843 OXA-622 OXA-622 OXA-623 is a OXA beta-lactamase. OXA-623 antibiotic_resistance ARO:3005844 OXA-623 OXA-623 OXA-624 is a OXA beta-lactamase. OXA-624 antibiotic_resistance ARO:3005845 OXA-624 OXA-624 OXA-625 is a OXA beta-lactamase. OXA-625 antibiotic_resistance ARO:3005846 OXA-625 OXA-625 OXA-626 is a OXA beta-lactamase. OXA-626 antibiotic_resistance ARO:3005847 OXA-626 OXA-626 OXA-627 is a OXA beta-lactamase. OXA-627 antibiotic_resistance ARO:3005848 OXA-627 OXA-627 OXA-628 is a OXA beta-lactamase. OXA-628 antibiotic_resistance ARO:3005849 OXA-628 OXA-628 OXA-629 is a OXA beta-lactamase. OXA-629 antibiotic_resistance ARO:3005850 OXA-629 OXA-629 OXA-630 is a OXA beta-lactamase. OXA-630 antibiotic_resistance ARO:3005851 OXA-630 OXA-630 OXA-631 is a OXA beta-lactamase. OXA-631 antibiotic_resistance ARO:3005852 OXA-631 OXA-631 OXA-632 is a OXA beta-lactamase. OXA-632 antibiotic_resistance ARO:3005853 OXA-632 OXA-632 OXA-633 is a OXA beta-lactamase. OXA-633 antibiotic_resistance ARO:3005854 OXA-633 OXA-633 OXA-634 is a OXA beta-lactamase. OXA-634 antibiotic_resistance ARO:3005855 OXA-634 OXA-634 OXA-635 is a OXA beta-lactamase. OXA-635 antibiotic_resistance ARO:3005856 OXA-635 OXA-635 OXA-636 is a OXA beta-lactamase. OXA-636 antibiotic_resistance ARO:3005857 OXA-636 OXA-636 OXA-637 is a OXA beta-lactamase. OXA-637 antibiotic_resistance ARO:3005858 OXA-637 OXA-637 OXA-638 is a OXA beta-lactamase. OXA-638 antibiotic_resistance ARO:3005859 OXA-638 OXA-638 OXA-639 is a OXA beta-lactamase. OXA-639 antibiotic_resistance ARO:3005860 OXA-639 OXA-639 OXA-640 is a OXA beta-lactamase. OXA-640 antibiotic_resistance ARO:3005861 OXA-640 OXA-640 OXA-642 is a OXA beta-lactamase. OXA-642 antibiotic_resistance ARO:3005862 OXA-642 OXA-642 OXA-643 is a OXA beta-lactamase. OXA-643 antibiotic_resistance ARO:3005863 OXA-643 OXA-643 OXA-644 is a OXA beta-lactamase. OXA-644 antibiotic_resistance ARO:3005864 OXA-644 OXA-644 OXA-645 is a OXA beta-lactamase. OXA-645 antibiotic_resistance ARO:3005865 OXA-645 OXA-645 OXA-650 is a OXA beta-lactamase. OXA-650 antibiotic_resistance ARO:3005866 OXA-650 OXA-650 OXA-651 is a OXA beta-lactamase. OXA-651 antibiotic_resistance ARO:3005867 OXA-651 OXA-651 OXA-652 is a OXA beta-lactamase. OXA-652 antibiotic_resistance ARO:3005868 OXA-652 OXA-652 OXA-654 is a OXA beta-lactamase. OXA-654 antibiotic_resistance ARO:3005869 OXA-654 OXA-654 OXA-655 is a OXA beta-lactamase. OXA-655 antibiotic_resistance ARO:3005870 OXA-655 OXA-655 OXA-656 is a OXA beta-lactamase. OXA-656 antibiotic_resistance ARO:3005871 OXA-656 OXA-656 OXA-657 is a OXA beta-lactamase. OXA-657 antibiotic_resistance ARO:3005872 OXA-657 OXA-657 OXA-658 is a OXA beta-lactamase. OXA-658 antibiotic_resistance ARO:3005873 OXA-658 OXA-658 OXA-659 is a OXA beta-lactamase. OXA-659 antibiotic_resistance ARO:3005874 OXA-659 OXA-659 OXA-660 is a OXA beta-lactamase. OXA-660 antibiotic_resistance ARO:3005875 OXA-660 OXA-660 OXA-661 is a OXA beta-lactamase. OXA-661 antibiotic_resistance ARO:3005876 OXA-661 OXA-661 OXA-662 is a OXA beta-lactamase. OXA-662 antibiotic_resistance ARO:3005877 OXA-662 OXA-662 OXA-666 is a OXA beta-lactamase. OXA-666 antibiotic_resistance ARO:3005878 OXA-666 OXA-666 OXA-667 is a OXA beta-lactamase. OXA-667 antibiotic_resistance ARO:3005879 OXA-667 OXA-667 OXA-669 is a OXA beta-lactamase. OXA-669 antibiotic_resistance ARO:3005880 OXA-669 OXA-669 OXA-670 is a OXA beta-lactamase. OXA-670 antibiotic_resistance ARO:3005881 OXA-670 OXA-670 OXA-674 is a OXA beta-lactamase. OXA-674 antibiotic_resistance ARO:3005882 OXA-674 OXA-674 OXA-675 is a OXA beta-lactamase. OXA-675 antibiotic_resistance ARO:3005883 OXA-675 OXA-675 OXA-676 is a OXA beta-lactamase. OXA-676 antibiotic_resistance ARO:3005884 OXA-676 OXA-676 OXA-677 is a OXA beta-lactamase. OXA-677 antibiotic_resistance ARO:3005885 OXA-677 OXA-677 OXA-678 is a OXA beta-lactamase. OXA-678 antibiotic_resistance ARO:3005886 OXA-678 OXA-678 OXA-679 is a OXA beta-lactamase. OXA-679 antibiotic_resistance ARO:3005887 OXA-679 OXA-679 OXA-680 is a OXA beta-lactamase. OXA-680 antibiotic_resistance ARO:3005888 OXA-680 OXA-680 OXA-682 is a OXA beta-lactamase. OXA-682 antibiotic_resistance ARO:3005889 OXA-682 OXA-682 OXA-683 is a OXA beta-lactamase. OXA-683 antibiotic_resistance ARO:3005890 OXA-683 OXA-683 OXA-684 is a OXA beta-lactamase. OXA-684 antibiotic_resistance ARO:3005891 OXA-684 OXA-684 OXA-685 is a OXA beta-lactamase. OXA-685 antibiotic_resistance ARO:3005892 OXA-685 OXA-685 OXA-686 is a OXA beta-lactamase. OXA-686 antibiotic_resistance ARO:3005893 OXA-686 OXA-686 OXA-687 is a OXA beta-lactamase. OXA-687 antibiotic_resistance ARO:3005894 OXA-687 OXA-687 OXA-688 is a OXA beta-lactamase. OXA-688 antibiotic_resistance ARO:3005895 OXA-688 OXA-688 OXA-689 is a OXA beta-lactamase. OXA-689 antibiotic_resistance ARO:3005896 OXA-689 OXA-689 OXA-690 is a OXA beta-lactamase. OXA-690 antibiotic_resistance ARO:3005897 OXA-690 OXA-690 OXA-691 is a OXA beta-lactamase. OXA-691 antibiotic_resistance ARO:3005898 OXA-691 OXA-691 OXA-692 is a OXA beta-lactamase. OXA-692 antibiotic_resistance ARO:3005899 OXA-692 OXA-692 OXA-693 is a OXA beta-lactamase. OXA-693 antibiotic_resistance ARO:3005900 OXA-693 OXA-693 OXA-694 is a OXA beta-lactamase. OXA-694 antibiotic_resistance ARO:3005901 OXA-694 OXA-694 OXA-695 is a OXA beta-lactamase. OXA-695 antibiotic_resistance ARO:3005902 OXA-695 OXA-695 OXA-696 is a OXA beta-lactamase. OXA-696 antibiotic_resistance ARO:3005903 OXA-696 OXA-696 OXA-697 is a OXA beta-lactamase. OXA-697 antibiotic_resistance ARO:3005904 OXA-697 OXA-697 OXA-698 is a OXA beta-lactamase. OXA-698 antibiotic_resistance ARO:3005905 OXA-698 OXA-698 OXA-699 is a OXA beta-lactamase. OXA-699 antibiotic_resistance ARO:3005906 OXA-699 OXA-699 OXA-700 is a OXA beta-lactamase. OXA-700 antibiotic_resistance ARO:3005907 OXA-700 OXA-700 OXA-701 is a OXA beta-lactamase. OXA-701 antibiotic_resistance ARO:3005908 OXA-701 OXA-701 OXA-702 is a OXA beta-lactamase. OXA-702 antibiotic_resistance ARO:3005909 OXA-702 OXA-702 OXA-703 is a OXA beta-lactamase. OXA-703 antibiotic_resistance ARO:3005910 OXA-703 OXA-703 OXA-704 is a OXA beta-lactamase. OXA-704 antibiotic_resistance ARO:3005911 OXA-704 OXA-704 OXA-705 is a OXA beta-lactamase. OXA-705 antibiotic_resistance ARO:3005912 OXA-705 OXA-705 OXA-706 is a OXA beta-lactamase. OXA-706 antibiotic_resistance ARO:3005913 OXA-706 OXA-706 OXA-707 is a OXA beta-lactamase. OXA-707 antibiotic_resistance ARO:3005914 OXA-707 OXA-707 OXA-708 is a OXA beta-lactamase. OXA-708 antibiotic_resistance ARO:3005915 OXA-708 OXA-708 OXA-709 is a OXA beta-lactamase. OXA-709 antibiotic_resistance ARO:3005916 OXA-709 OXA-709 OXA-710 is a OXA beta-lactamase. OXA-710 antibiotic_resistance ARO:3005917 OXA-710 OXA-710 OXA-711 is a OXA beta-lactamase. OXA-711 antibiotic_resistance ARO:3005918 OXA-711 OXA-711 OXA-712 is a OXA beta-lactamase. OXA-712 antibiotic_resistance ARO:3005919 OXA-712 OXA-712 OXA-713 is a OXA beta-lactamase. OXA-713 antibiotic_resistance ARO:3005920 OXA-713 OXA-713 OXA-714 is a OXA beta-lactamase. OXA-714 antibiotic_resistance ARO:3005921 OXA-714 OXA-714 OXA-715 is a OXA beta-lactamase. OXA-715 antibiotic_resistance ARO:3005922 OXA-715 OXA-715 OXA-716 is a OXA beta-lactamase. OXA-716 antibiotic_resistance ARO:3005923 OXA-716 OXA-716 OXA-717 is a OXA beta-lactamase. OXA-717 antibiotic_resistance ARO:3005924 OXA-717 OXA-717 OXA-718 is a OXA beta-lactamase. OXA-718 antibiotic_resistance ARO:3005925 OXA-718 OXA-718 OXA-719 is a OXA beta-lactamase. OXA-719 antibiotic_resistance ARO:3005926 OXA-719 OXA-719 OXA-720 is a OXA beta-lactamase. OXA-720 antibiotic_resistance ARO:3005927 OXA-720 OXA-720 OXA-721 is a OXA beta-lactamase. OXA-721 antibiotic_resistance ARO:3005928 OXA-721 OXA-721 OXA-722 is a OXA beta-lactamase. OXA-722 antibiotic_resistance ARO:3005929 OXA-722 OXA-722 OXA-723 is a OXA beta-lactamase. OXA-723 antibiotic_resistance ARO:3005930 OXA-723 OXA-723 OXA-726 is a OXA beta-lactamase. OXA-726 antibiotic_resistance ARO:3005931 OXA-726 OXA-726 OXA-727 is a OXA beta-lactamase. OXA-727 antibiotic_resistance ARO:3005932 OXA-727 OXA-727 OXA-728 is a OXA beta-lactamase. OXA-728 antibiotic_resistance ARO:3005933 OXA-728 OXA-728 OXA-729 is a OXA beta-lactamase. OXA-729 antibiotic_resistance ARO:3005934 OXA-729 OXA-729 OXA-730 is a OXA beta-lactamase. OXA-730 antibiotic_resistance ARO:3005935 OXA-730 OXA-730 OXA-731 is a OXA beta-lactamase. OXA-731 antibiotic_resistance ARO:3005936 OXA-731 OXA-731 OXA-732 is a OXA beta-lactamase. OXA-732 antibiotic_resistance ARO:3005937 OXA-732 OXA-732 OXA-733 is a OXA beta-lactamase. OXA-733 antibiotic_resistance ARO:3005938 OXA-733 OXA-733 OXA-734 is a OXA beta-lactamase. OXA-734 antibiotic_resistance ARO:3005939 OXA-734 OXA-734 OXA-735 is a OXA beta-lactamase. OXA-735 antibiotic_resistance ARO:3005940 OXA-735 OXA-735 OXA-736 is a OXA beta-lactamase. OXA-736 antibiotic_resistance ARO:3005941 OXA-736 OXA-736 OXA-738 is a OXA beta-lactamase. OXA-738 antibiotic_resistance ARO:3005942 OXA-738 OXA-738 OXA-739 is a OXA beta-lactamase. OXA-739 antibiotic_resistance ARO:3005943 OXA-739 OXA-739 OXA-740 is a OXA beta-lactamase. OXA-740 antibiotic_resistance ARO:3005944 OXA-740 OXA-740 OXA-741 is a OXA beta-lactamase. OXA-741 antibiotic_resistance ARO:3005945 OXA-741 OXA-741 OXA-742 is a OXA beta-lactamase. OXA-742 antibiotic_resistance ARO:3005946 OXA-742 OXA-742 OXA-743 is a OXA beta-lactamase. OXA-743 antibiotic_resistance ARO:3005947 OXA-743 OXA-743 OXA-744 is a OXA beta-lactamase. OXA-744 antibiotic_resistance ARO:3005948 OXA-744 OXA-744 OXA-745 is a OXA beta-lactamase. OXA-745 antibiotic_resistance ARO:3005949 OXA-745 OXA-745 OXA-746 is a OXA beta-lactamase. OXA-746 antibiotic_resistance ARO:3005950 OXA-746 OXA-746 OXA-747 is a OXA beta-lactamase. OXA-747 antibiotic_resistance ARO:3005951 OXA-747 OXA-747 OXA-748 is a OXA beta-lactamase. OXA-748 antibiotic_resistance ARO:3005952 OXA-748 OXA-748 OXA-749 is a OXA beta-lactamase. OXA-749 antibiotic_resistance ARO:3005953 OXA-749 OXA-749 OXA-750 is a OXA beta-lactamase. OXA-750 antibiotic_resistance ARO:3005954 OXA-750 OXA-750 OXA-751 is a OXA beta-lactamase. OXA-751 antibiotic_resistance ARO:3005955 OXA-751 OXA-751 OXA-752 is a OXA beta-lactamase. OXA-752 antibiotic_resistance ARO:3005956 OXA-752 OXA-752 OXA-753 is a OXA beta-lactamase. OXA-753 antibiotic_resistance ARO:3005957 OXA-753 OXA-753 OXA-754 is a OXA beta-lactamase. OXA-754 antibiotic_resistance ARO:3005958 OXA-754 OXA-754 OXA-755 is a OXA beta-lactamase. OXA-755 antibiotic_resistance ARO:3005959 OXA-755 OXA-755 OXA-756 is a OXA beta-lactamase. OXA-756 antibiotic_resistance ARO:3005960 OXA-756 OXA-756 OXA-757 is a OXA beta-lactamase. OXA-757 antibiotic_resistance ARO:3005961 OXA-757 OXA-757 OXA-758 is a OXA beta-lactamase. OXA-758 antibiotic_resistance ARO:3005962 OXA-758 OXA-758 OXA-759 is a OXA beta-lactamase. OXA-759 antibiotic_resistance ARO:3005963 OXA-759 OXA-759 OXA-760 is a OXA beta-lactamase. OXA-760 antibiotic_resistance ARO:3005964 OXA-760 OXA-760 OXA-761 is a OXA beta-lactamase. OXA-761 antibiotic_resistance ARO:3005965 OXA-761 OXA-761 OXA-762 is a OXA beta-lactamase. OXA-762 antibiotic_resistance ARO:3005966 OXA-762 OXA-762 OXA-763 is a OXA beta-lactamase. OXA-763 antibiotic_resistance ARO:3005967 OXA-763 OXA-763 OXA-764 is a OXA beta-lactamase. OXA-764 antibiotic_resistance ARO:3005968 OXA-764 OXA-764 OXA-765 is a OXA beta-lactamase. OXA-765 antibiotic_resistance ARO:3005969 OXA-765 OXA-765 OXA-766 is a OXA beta-lactamase. OXA-766 antibiotic_resistance ARO:3005970 OXA-766 OXA-766 OXA-767 is a OXA beta-lactamase. OXA-767 antibiotic_resistance ARO:3005971 OXA-767 OXA-767 OXA-768 is a OXA beta-lactamase. OXA-768 antibiotic_resistance ARO:3005972 OXA-768 OXA-768 OXA-769 is a OXA beta-lactamase. OXA-769 antibiotic_resistance ARO:3005973 OXA-769 OXA-769 OXA-770 is a OXA beta-lactamase. OXA-770 antibiotic_resistance ARO:3005974 OXA-770 OXA-770 OXA-771 is a OXA beta-lactamase. OXA-771 antibiotic_resistance ARO:3005975 OXA-771 OXA-771 OXA-772 is a OXA beta-lactamase. OXA-772 antibiotic_resistance ARO:3005976 OXA-772 OXA-772 OXA-773 is a OXA beta-lactamase. OXA-773 antibiotic_resistance ARO:3005977 OXA-773 OXA-773 OXA-774 is a OXA beta-lactamase. OXA-774 antibiotic_resistance ARO:3005978 OXA-774 OXA-774 OXA-775 is a OXA beta-lactamase. OXA-775 antibiotic_resistance ARO:3005979 OXA-775 OXA-775 OXA-776 is a OXA beta-lactamase. OXA-776 antibiotic_resistance ARO:3005980 OXA-776 OXA-776 OXA-777 is a OXA beta-lactamase. OXA-777 antibiotic_resistance ARO:3005981 OXA-777 OXA-777 OXA-778 is a OXA beta-lactamase. OXA-778 antibiotic_resistance ARO:3005982 OXA-778 OXA-778 OXA-780 is a OXA beta-lactamase. OXA-780 antibiotic_resistance ARO:3005983 OXA-780 OXA-780 OXA-781 is a OXA beta-lactamase. OXA-781 antibiotic_resistance ARO:3005984 OXA-781 OXA-781 OXA-782 is a OXA beta-lactamase. OXA-782 antibiotic_resistance ARO:3005985 OXA-782 OXA-782 OXA-783 is a OXA beta-lactamase. OXA-783 antibiotic_resistance ARO:3005986 OXA-783 OXA-783 OXA-784 is a OXA beta-lactamase. OXA-784 antibiotic_resistance ARO:3005987 OXA-784 OXA-784 OXA-785 is a OXA beta-lactamase. OXA-785 antibiotic_resistance ARO:3005988 OXA-785 OXA-785 OXA-786 is a OXA beta-lactamase. OXA-786 antibiotic_resistance ARO:3005989 OXA-786 OXA-786 OXA-787 is a OXA beta-lactamase. OXA-787 antibiotic_resistance ARO:3005990 OXA-787 OXA-787 OXA-788 is a OXA beta-lactamase. OXA-788 antibiotic_resistance ARO:3005991 OXA-788 OXA-788 OXA-789 is a OXA beta-lactamase. OXA-789 antibiotic_resistance ARO:3005992 OXA-789 OXA-789 OXA-793 is a OXA beta-lactamase. OXA-793 antibiotic_resistance ARO:3005993 OXA-793 OXA-793 OXA-794 is a OXA beta-lactamase. OXA-794 antibiotic_resistance ARO:3005994 OXA-794 OXA-794 OXA-795 is a OXA beta-lactamase. OXA-795 antibiotic_resistance ARO:3005995 OXA-795 OXA-795 OXA-796 is a OXA beta-lactamase. OXA-796 antibiotic_resistance ARO:3005996 OXA-796 OXA-796 OXA-797 is a OXA beta-lactamase. OXA-797 antibiotic_resistance ARO:3005997 OXA-797 OXA-797 OXA-798 is a OXA beta-lactamase. OXA-798 antibiotic_resistance ARO:3005998 OXA-798 OXA-798 OXA-799 is a OXA beta-lactamase. OXA-799 antibiotic_resistance ARO:3005999 OXA-799 OXA-799 OXA-800 is a OXA beta-lactamase. OXA-800 antibiotic_resistance ARO:3006000 OXA-800 OXA-800 OXA-801 is a OXA beta-lactamase. OXA-801 antibiotic_resistance ARO:3006001 OXA-801 OXA-801 OXA-802 is a OXA beta-lactamase. OXA-802 antibiotic_resistance ARO:3006002 OXA-802 OXA-802 OXA-803 is a OXA beta-lactamase. OXA-803 antibiotic_resistance ARO:3006003 OXA-803 OXA-803 OXA-804 is a OXA beta-lactamase. OXA-804 antibiotic_resistance ARO:3006004 OXA-804 OXA-804 OXA-805 is a OXA beta-lactamase. OXA-805 antibiotic_resistance ARO:3006005 OXA-805 OXA-805 OXA-806 is a OXA beta-lactamase. OXA-806 antibiotic_resistance ARO:3006006 OXA-806 OXA-806 OXA-807 is a OXA beta-lactamase. OXA-807 antibiotic_resistance ARO:3006007 OXA-807 OXA-807 OXA-808 is a OXA beta-lactamase. OXA-808 antibiotic_resistance ARO:3006008 OXA-808 OXA-808 OXA-809 is a OXA beta-lactamase. OXA-809 antibiotic_resistance ARO:3006009 OXA-809 OXA-809 OXA-810 is a OXA beta-lactamase. OXA-810 antibiotic_resistance ARO:3006010 OXA-810 OXA-810 OXA-811 is a OXA beta-lactamase. OXA-811 antibiotic_resistance ARO:3006011 OXA-811 OXA-811 OXA-813 is a OXA beta-lactamase. OXA-813 antibiotic_resistance ARO:3006012 OXA-813 OXA-813 OXA-814 is a OXA beta-lactamase. OXA-814 antibiotic_resistance ARO:3006013 OXA-814 OXA-814 OXA-815 is a OXA beta-lactamase. OXA-815 antibiotic_resistance ARO:3006014 OXA-815 OXA-815 OXA-816 is a OXA beta-lactamase. OXA-816 antibiotic_resistance ARO:3006015 OXA-816 OXA-816 OXA-817 is a OXA beta-lactamase. OXA-817 antibiotic_resistance ARO:3006016 OXA-817 OXA-817 OXA-819 is a OXA beta-lactamase. OXA-819 antibiotic_resistance ARO:3006017 OXA-819 OXA-819 OXA-820 is a OXA beta-lactamase. OXA-820 antibiotic_resistance ARO:3006018 OXA-820 OXA-820 OXA-821 is a OXA beta-lactamase. OXA-821 antibiotic_resistance ARO:3006019 OXA-821 OXA-821 OXA-822 is a OXA beta-lactamase. OXA-822 antibiotic_resistance ARO:3006020 OXA-822 OXA-822 OXA-823 is a OXA beta-lactamase. OXA-823 antibiotic_resistance ARO:3006021 OXA-823 OXA-823 OXA-824 is a OXA beta-lactamase. OXA-824 antibiotic_resistance ARO:3006022 OXA-824 OXA-824 OXA-826 is a OXA beta-lactamase. OXA-826 antibiotic_resistance ARO:3006023 OXA-826 OXA-826 OXA-827 is a OXA beta-lactamase. OXA-827 antibiotic_resistance ARO:3006024 OXA-827 OXA-827 OXA-828 is a OXA beta-lactamase. OXA-828 antibiotic_resistance ARO:3006025 OXA-828 OXA-828 OXA-829 is a OXA beta-lactamase. OXA-829 antibiotic_resistance ARO:3006026 OXA-829 OXA-829 OXA-830 is a OXA beta-lactamase. OXA-830 antibiotic_resistance ARO:3006027 OXA-830 OXA-830 OXA-831 is a OXA beta-lactamase. OXA-831 antibiotic_resistance ARO:3006028 OXA-831 OXA-831 OXA-832 is a OXA beta-lactamase. OXA-832 antibiotic_resistance ARO:3006029 OXA-832 OXA-832 OXA-833 is a OXA beta-lactamase. OXA-833 antibiotic_resistance ARO:3006030 OXA-833 OXA-833 OXA-834 is a OXA beta-lactamase. OXA-834 antibiotic_resistance ARO:3006031 OXA-834 OXA-834 OXA-836 is a OXA beta-lactamase. OXA-836 antibiotic_resistance ARO:3006032 OXA-836 OXA-836 OXA-839 is a OXA beta-lactamase. OXA-839 antibiotic_resistance ARO:3006033 OXA-839 OXA-839 OXA-840 is a OXA beta-lactamase. OXA-840 antibiotic_resistance ARO:3006034 OXA-840 OXA-840 OXA-841 is a OXA beta-lactamase. OXA-841 antibiotic_resistance ARO:3006035 OXA-841 OXA-841 OXA-842 is a OXA beta-lactamase. OXA-842 antibiotic_resistance ARO:3006036 OXA-842 OXA-842 OXA-843 is a OXA beta-lactamase. OXA-843 antibiotic_resistance ARO:3006037 OXA-843 OXA-843 OXA-844 is a OXA beta-lactamase. OXA-844 antibiotic_resistance ARO:3006038 OXA-844 OXA-844 OXA-845 is a OXA beta-lactamase. OXA-845 antibiotic_resistance ARO:3006039 OXA-845 OXA-845 OXA-847 is a OXA beta-lactamase. OXA-847 antibiotic_resistance ARO:3006040 OXA-847 OXA-847 OXA-848 is a OXA beta-lactamase. OXA-848 antibiotic_resistance ARO:3006041 OXA-848 OXA-848 OXA-849 is a OXA beta-lactamase. OXA-849 antibiotic_resistance ARO:3006042 OXA-849 OXA-849 OXA-851 is a OXA beta-lactamase. OXA-851 antibiotic_resistance ARO:3006043 OXA-851 OXA-851 OXA-852 is a OXA beta-lactamase. OXA-852 antibiotic_resistance ARO:3006044 OXA-852 OXA-852 OXA-853 is a OXA beta-lactamase. OXA-853 antibiotic_resistance ARO:3006045 OXA-853 OXA-853 OXA-854 is a OXA beta-lactamase. OXA-854 antibiotic_resistance ARO:3006046 OXA-854 OXA-854 OXA-855 is a OXA beta-lactamase. OXA-855 antibiotic_resistance ARO:3006047 OXA-855 OXA-855 OXA-856 is a OXA beta-lactamase. OXA-856 antibiotic_resistance ARO:3006048 OXA-856 OXA-856 OXA-857 is a OXA beta-lactamase. OXA-857 antibiotic_resistance ARO:3006049 OXA-857 OXA-857 OXA-858 is a OXA beta-lactamase. OXA-858 antibiotic_resistance ARO:3006050 OXA-858 OXA-858 OXA-859 is a OXA beta-lactamase. OXA-859 antibiotic_resistance ARO:3006051 OXA-859 OXA-859 OXA-860 is a OXA beta-lactamase. OXA-860 antibiotic_resistance ARO:3006052 OXA-860 OXA-860 OXA-861 is a OXA beta-lactamase. OXA-861 antibiotic_resistance ARO:3006053 OXA-861 OXA-861 OXA-862 is a OXA beta-lactamase. OXA-862 antibiotic_resistance ARO:3006054 OXA-862 OXA-862 OXA-863 is a OXA beta-lactamase. OXA-863 antibiotic_resistance ARO:3006055 OXA-863 OXA-863 OXA-864 is a OXA beta-lactamase. OXA-864 antibiotic_resistance ARO:3006056 OXA-864 OXA-864 OXA-865 is a OXA beta-lactamase. OXA-865 antibiotic_resistance ARO:3006057 OXA-865 OXA-865 OXA-866 is a OXA beta-lactamase. OXA-866 antibiotic_resistance ARO:3006058 OXA-866 OXA-866 OXA-867 is a OXA beta-lactamase. OXA-867 antibiotic_resistance ARO:3006059 OXA-867 OXA-867 OXA-868 is a OXA beta-lactamase. OXA-868 antibiotic_resistance ARO:3006060 OXA-868 OXA-868 OXA-869 is a OXA beta-lactamase. OXA-869 antibiotic_resistance ARO:3006061 OXA-869 OXA-869 OXA-870 is a OXA beta-lactamase. OXA-870 antibiotic_resistance ARO:3006062 OXA-870 OXA-870 OXA-871 is a OXA beta-lactamase. OXA-871 antibiotic_resistance ARO:3006063 OXA-871 OXA-871 OXA-872 is a OXA beta-lactamase. OXA-872 antibiotic_resistance ARO:3006064 OXA-872 OXA-872 OXA-873 is a OXA beta-lactamase. OXA-873 antibiotic_resistance ARO:3006065 OXA-873 OXA-873 OXA-874 is a OXA beta-lactamase. OXA-874 antibiotic_resistance ARO:3006066 OXA-874 OXA-874 OXA-875 is a OXA beta-lactamase. OXA-875 antibiotic_resistance ARO:3006067 OXA-875 OXA-875 OXA-876 is a OXA beta-lactamase. OXA-876 antibiotic_resistance ARO:3006068 OXA-876 OXA-876 OXA-877 is a OXA beta-lactamase. OXA-877 antibiotic_resistance ARO:3006069 OXA-877 OXA-877 OXA-878 is a OXA beta-lactamase. OXA-878 antibiotic_resistance ARO:3006070 OXA-878 OXA-878 OXA-879 is a OXA beta-lactamase. OXA-879 antibiotic_resistance ARO:3006071 OXA-879 OXA-879 OXA-880 is a OXA beta-lactamase. OXA-880 antibiotic_resistance ARO:3006072 OXA-880 OXA-880 OXA-881 is a OXA beta-lactamase. OXA-881 antibiotic_resistance ARO:3006073 OXA-881 OXA-881 OXA-882 is a OXA beta-lactamase. OXA-882 antibiotic_resistance ARO:3006074 OXA-882 OXA-882 OXA-883 is a OXA beta-lactamase. OXA-883 antibiotic_resistance ARO:3006075 OXA-883 OXA-883 OXA-884 is a OXA beta-lactamase. OXA-884 antibiotic_resistance ARO:3006076 OXA-884 OXA-884 OXA-885 is a OXA beta-lactamase. OXA-885 antibiotic_resistance ARO:3006077 OXA-885 OXA-885 OXA-886 is a OXA beta-lactamase. OXA-886 antibiotic_resistance ARO:3006078 OXA-886 OXA-886 OXA-887 is a OXA beta-lactamase. OXA-887 antibiotic_resistance ARO:3006079 OXA-887 OXA-887 OXA-888 is a OXA beta-lactamase. OXA-888 antibiotic_resistance ARO:3006080 OXA-888 OXA-888 OXA-889 is a OXA beta-lactamase. OXA-889 antibiotic_resistance ARO:3006081 OXA-889 OXA-889 OXA-890 is a OXA beta-lactamase. OXA-890 antibiotic_resistance ARO:3006082 OXA-890 OXA-890 OXA-891 is a OXA beta-lactamase. OXA-891 antibiotic_resistance ARO:3006083 OXA-891 OXA-891 OXA-892 is a OXA beta-lactamase. OXA-892 antibiotic_resistance ARO:3006084 OXA-892 OXA-892 OXA-893 is a OXA beta-lactamase. OXA-893 antibiotic_resistance ARO:3006085 OXA-893 OXA-893 OXA-894 is a OXA beta-lactamase. OXA-894 antibiotic_resistance ARO:3006086 OXA-894 OXA-894 OXA-896 is a OXA beta-lactamase. OXA-896 antibiotic_resistance ARO:3006087 OXA-896 OXA-896 OXA-900 is a OXA beta-lactamase. OXA-900 antibiotic_resistance ARO:3006088 OXA-900 OXA-900 OXA-901 is a OXA beta-lactamase. OXA-901 antibiotic_resistance ARO:3006089 OXA-901 OXA-901 OXA-902 is a OXA beta-lactamase. OXA-902 antibiotic_resistance ARO:3006090 OXA-902 OXA-902 OXA-903 is a OXA beta-lactamase. OXA-903 antibiotic_resistance ARO:3006091 OXA-903 OXA-903 OXA-904 is a OXA beta-lactamase. OXA-904 antibiotic_resistance ARO:3006092 OXA-904 OXA-904 OXA-905 is a OXA beta-lactamase. OXA-905 antibiotic_resistance ARO:3006093 OXA-905 OXA-905 OXA-907 is a OXA beta-lactamase. OXA-907 antibiotic_resistance ARO:3006094 OXA-907 OXA-907 OXA-908 is a OXA beta-lactamase. OXA-908 antibiotic_resistance ARO:3006095 OXA-908 OXA-908 OXA-909 is a OXA beta-lactamase. OXA-909 antibiotic_resistance ARO:3006096 OXA-909 OXA-909 OXA-910 is a OXA beta-lactamase. OXA-910 antibiotic_resistance ARO:3006097 OXA-910 OXA-910 OXA-911 is a OXA beta-lactamase. OXA-911 antibiotic_resistance ARO:3006098 OXA-911 OXA-911 OXA-912 is a OXA beta-lactamase. OXA-912 antibiotic_resistance ARO:3006099 OXA-912 OXA-912 OXA-913 is a OXA beta-lactamase. OXA-913 antibiotic_resistance ARO:3006100 OXA-913 OXA-913 OXA-914 is a OXA beta-lactamase. OXA-914 antibiotic_resistance ARO:3006101 OXA-914 OXA-914 OXA-916 is a OXA beta-lactamase. OXA-916 antibiotic_resistance ARO:3006102 OXA-916 OXA-916 OXA-917 is a OXA beta-lactamase. OXA-917 antibiotic_resistance ARO:3006103 OXA-917 OXA-917 OXA-918 is a OXA beta-lactamase. OXA-918 antibiotic_resistance ARO:3006104 OXA-918 OXA-918 OXA-919 is a OXA beta-lactamase. OXA-919 antibiotic_resistance ARO:3006105 OXA-919 OXA-919 OXA-920 is a OXA beta-lactamase. OXA-920 antibiotic_resistance ARO:3006106 OXA-920 OXA-920 OXA-921 is a OXA beta-lactamase. OXA-921 antibiotic_resistance ARO:3006107 OXA-921 OXA-921 OXA-922 is a OXA beta-lactamase. OXA-922 antibiotic_resistance ARO:3006108 OXA-922 OXA-922 OXA-923 is a OXA beta-lactamase. OXA-923 antibiotic_resistance ARO:3006109 OXA-923 OXA-923 OXA-924 is a OXA beta-lactamase. OXA-924 antibiotic_resistance ARO:3006110 OXA-924 OXA-924 OXA-925 is a OXA beta-lactamase. OXA-925 antibiotic_resistance ARO:3006111 OXA-925 OXA-925 OXA-927 is a OXA beta-lactamase. OXA-927 antibiotic_resistance ARO:3006112 OXA-927 OXA-927 OXA-928 is a OXA beta-lactamase. OXA-928 antibiotic_resistance ARO:3006113 OXA-928 OXA-928 OXA-929 is a OXA beta-lactamase. OXA-929 antibiotic_resistance ARO:3006114 OXA-929 OXA-929 OXA-932 is a OXA beta-lactamase. OXA-932 antibiotic_resistance ARO:3006115 OXA-932 OXA-932 OXA-935 is a OXA beta-lactamase. OXA-935 antibiotic_resistance ARO:3006116 OXA-935 OXA-935 OXA-937 is a OXA beta-lactamase. OXA-937 antibiotic_resistance ARO:3006117 OXA-937 OXA-937 OXA-938 is a OXA beta-lactamase. OXA-938 antibiotic_resistance ARO:3006118 OXA-938 OXA-938 OXA-939 is a OXA beta-lactamase. OXA-939 antibiotic_resistance ARO:3006119 OXA-939 OXA-939 OXA-940 is a OXA beta-lactamase. OXA-940 antibiotic_resistance ARO:3006120 OXA-940 OXA-940 OXA-941 is a OXA beta-lactamase. OXA-941 antibiotic_resistance ARO:3006121 OXA-941 OXA-941 OXA-942 is a OXA beta-lactamase. OXA-942 antibiotic_resistance ARO:3006122 OXA-942 OXA-942 OXA-943 is a OXA beta-lactamase. OXA-943 antibiotic_resistance ARO:3006123 OXA-943 OXA-943 OXA-945 is a OXA beta-lactamase. OXA-945 antibiotic_resistance ARO:3006124 OXA-945 OXA-945 OXA-946 is a OXA beta-lactamase. OXA-946 antibiotic_resistance ARO:3006125 OXA-946 OXA-946 OXA-947 is a OXA beta-lactamase. OXA-947 antibiotic_resistance ARO:3006126 OXA-947 OXA-947 OXA-948 is a OXA beta-lactamase. OXA-948 antibiotic_resistance ARO:3006127 OXA-948 OXA-948 OXA-949 is a OXA beta-lactamase. OXA-949 antibiotic_resistance ARO:3006128 OXA-949 OXA-949 OXY-2-14 is a OXY beta-lactamase. OXY-2-14 antibiotic_resistance ARO:3006129 OXY-2-14 OXY-2-14 OXY-2-15 is a OXY beta-lactamase. OXY-2-15 antibiotic_resistance ARO:3006130 OXY-2-15 OXY-2-15 PER-10 is a PER beta-lactamase. PER-10 antibiotic_resistance ARO:3006131 PER-10 PER-10 PER-11 is a PER beta-lactamase. PER-11 antibiotic_resistance ARO:3006132 PER-11 PER-11 PER-12 is a PER beta-lactamase. PER-12 antibiotic_resistance ARO:3006133 PER-12 PER-12 PER-13 is a PER beta-lactamase. PER-13 antibiotic_resistance ARO:3006134 PER-13 PER-13 PER-14 is a PER beta-lactamase. PER-14 antibiotic_resistance ARO:3006135 PER-14 PER-14 PER-15 is a PER beta-lactamase. PER-15 antibiotic_resistance ARO:3006136 PER-15 PER-15 PER-16 is a PER beta-lactamase. PER-16 antibiotic_resistance ARO:3006137 PER-16 PER-16 PER-9 is a PER beta-lactamase. PER-9 antibiotic_resistance ARO:3006138 PER-9 PER-9 TEM-98 is a TEM beta-lactamase. TEM-98 antibiotic_resistance ARO:3006139 TEM-98 TEM-98 TEM-99 is a TEM beta-lactamase. TEM-99 antibiotic_resistance ARO:3006140 TEM-99 TEM-99 OKP-A-17 is a OKP beta-lactamase. OKP-A-17 antibiotic_resistance ARO:3006141 OKP-A-17 OKP-A-17 OKP-B-16 is a OKP beta-lactamase. OKP-B-16 antibiotic_resistance ARO:3006142 OKP-B-16 OKP-B-16 OKP-B-21 is a OKP beta-lactamase. OKP-B-21 antibiotic_resistance ARO:3006143 OKP-B-21 OKP-B-21 OKP-B-22 is a OKP beta-lactamase. OKP-B-22 antibiotic_resistance ARO:3006144 OKP-B-22 OKP-B-22 OKP-B-23 is a OKP beta-lactamase. OKP-B-23 antibiotic_resistance ARO:3006145 OKP-B-23 OKP-B-23 OKP-B-24 is a OKP beta-lactamase. OKP-B-24 antibiotic_resistance ARO:3006146 OKP-B-24 OKP-B-24 OKP-B-34 is a OKP beta-lactamase. OKP-B-34 antibiotic_resistance ARO:3006147 OKP-B-34 OKP-B-34 OKP-B-36 is a OKP beta-lactamase. OKP-B-36 antibiotic_resistance ARO:3006148 OKP-B-36 OKP-B-36 OKP-B-40 is a OKP beta-lactamase. OKP-B-40 antibiotic_resistance ARO:3006149 OKP-B-40 OKP-B-40 OKP-B-41 is a OKP beta-lactamase. OKP-B-41 antibiotic_resistance ARO:3006150 OKP-B-41 OKP-B-41 OKP-B-45 is a OKP beta-lactamase. OKP-B-45 antibiotic_resistance ARO:3006151 OKP-B-45 OKP-B-45 OKP-C-1 is a OKP beta-lactamase. OKP-C-1 antibiotic_resistance ARO:3006152 OKP-C-1 OKP-C-1 OKP-D-1 is a OKP beta-lactamase. OKP-D-1 antibiotic_resistance ARO:3006153 OKP-D-1 OKP-D-1 BEL-4 is a BEL beta-lactamase. BEL-4 antibiotic_resistance ARO:3006154 BEL-4 BEL-4 CME-2 is a CME beta-lactamase. CME-2 antibiotic_resistance ARO:3006155 CME-2 CME-2 GES-27 is a GES beta-lactamase. GES-27 antibiotic_resistance ARO:3006156 GES-27 GES-27 GES-28 is a GES beta-lactamase. GES-28 antibiotic_resistance ARO:3006157 GES-28 GES-28 GES-29 is a GES beta-lactamase. GES-29 antibiotic_resistance ARO:3006158 GES-29 GES-29 GES-30 is a GES beta-lactamase. GES-30 antibiotic_resistance ARO:3006159 GES-30 GES-30 GES-31 is a GES beta-lactamase. GES-31 antibiotic_resistance ARO:3006160 GES-31 GES-31 GES-32 is a GES beta-lactamase. GES-32 antibiotic_resistance ARO:3006161 GES-32 GES-32 GES-33 is a GES beta-lactamase. GES-33 antibiotic_resistance ARO:3006162 GES-33 GES-33 GES-34 is a GES beta-lactamase. GES-34 antibiotic_resistance ARO:3006163 GES-34 GES-34 GES-35 is a GES beta-lactamase. GES-35 antibiotic_resistance ARO:3006164 GES-35 GES-35 GES-36 is a GES beta-lactamase. GES-36 antibiotic_resistance ARO:3006165 GES-36 GES-36 GES-37 is a GES beta-lactamase. GES-37 antibiotic_resistance ARO:3006166 GES-37 GES-37 GES-38 is a GES beta-lactamase. GES-38 antibiotic_resistance ARO:3006167 GES-38 GES-38 GES-39 is a GES beta-lactamase. GES-39 antibiotic_resistance ARO:3006168 GES-39 GES-39 GES-40 is a GES beta-lactamase. GES-40 antibiotic_resistance ARO:3006169 GES-40 GES-40 GES-41 is a GES beta-lactamase. GES-41 antibiotic_resistance ARO:3006170 GES-41 GES-41 GES-42 is a GES beta-lactamase. GES-42 antibiotic_resistance ARO:3006171 GES-42 GES-42 GES-43 is a GES beta-lactamase. GES-43 antibiotic_resistance ARO:3006172 GES-43 GES-43 GES-44 is a GES beta-lactamase. GES-44 antibiotic_resistance ARO:3006173 GES-44 GES-44 GES-45 is a GES beta-lactamase. GES-45 antibiotic_resistance ARO:3006174 GES-45 GES-45 GES-46 is a GES beta-lactamase. GES-46 antibiotic_resistance ARO:3006175 GES-46 GES-46 IMI-12 is a IMI beta-lactamase. IMI-12 antibiotic_resistance ARO:3006176 IMI-12 IMI-12 IMI-13 is a IMI beta-lactamase. IMI-13 antibiotic_resistance ARO:3006177 IMI-13 IMI-13 IMI-14 is a IMI beta-lactamase. IMI-14 antibiotic_resistance ARO:3006178 IMI-14 IMI-14 IMI-15 is a IMI beta-lactamase. IMI-15 antibiotic_resistance ARO:3006179 IMI-15 IMI-15 IMI-16 is a IMI beta-lactamase. IMI-16 antibiotic_resistance ARO:3006180 IMI-16 IMI-16 IMI-17 is a IMI beta-lactamase. IMI-17 antibiotic_resistance ARO:3006181 IMI-17 IMI-17 IMI-18 is a IMI beta-lactamase. IMI-18 antibiotic_resistance ARO:3006182 IMI-18 IMI-18 IMI-19 is a IMI beta-lactamase. IMI-19 antibiotic_resistance ARO:3006183 IMI-19 IMI-19 IMI-20 is a IMI beta-lactamase. IMI-20 antibiotic_resistance ARO:3006184 IMI-20 IMI-20 IMI-21 is a IMI beta-lactamase. IMI-21 antibiotic_resistance ARO:3006185 IMI-21 IMI-21 KPC-44 is a KPC beta-lactamase. KPC-44 antibiotic_resistance ARO:3006186 KPC-44 KPC-44 KPC-58 is a KPC beta-lactamase. KPC-58 antibiotic_resistance ARO:3006187 KPC-58 KPC-58 KPC-59 is a KPC beta-lactamase. KPC-59 antibiotic_resistance ARO:3006188 KPC-59 KPC-59 KPC-60 is a KPC beta-lactamase. KPC-60 antibiotic_resistance ARO:3006189 KPC-60 KPC-60 KPC-61 is a KPC beta-lactamase. KPC-61 antibiotic_resistance ARO:3006190 KPC-61 KPC-61 KPC-62 is a KPC beta-lactamase. KPC-62 antibiotic_resistance ARO:3006191 KPC-62 KPC-62 KPC-63 is a KPC beta-lactamase. KPC-63 antibiotic_resistance ARO:3006192 KPC-63 KPC-63 KPC-64 is a KPC beta-lactamase. KPC-64 antibiotic_resistance ARO:3006193 KPC-64 KPC-64 KPC-65 is a KPC beta-lactamase. KPC-65 antibiotic_resistance ARO:3006194 KPC-65 KPC-65 KPC-66 is a KPC beta-lactamase. KPC-66 antibiotic_resistance ARO:3006195 KPC-66 KPC-66 KPC-71 is a KPC beta-lactamase. KPC-71 antibiotic_resistance ARO:3006196 KPC-71 KPC-71 KPC-72 is a KPC beta-lactamase. KPC-72 antibiotic_resistance ARO:3006197 KPC-72 KPC-72 KPC-73 is a KPC beta-lactamase. KPC-73 antibiotic_resistance ARO:3006198 KPC-73 KPC-73 KPC-74 is a KPC beta-lactamase. KPC-74 antibiotic_resistance ARO:3006199 KPC-74 KPC-74 KPC-75 is a KPC beta-lactamase. KPC-75 antibiotic_resistance ARO:3006200 KPC-75 KPC-75 KPC-76 is a KPC beta-lactamase. KPC-76 antibiotic_resistance ARO:3006201 KPC-76 KPC-76 KPC-77 is a KPC beta-lactamase. KPC-77 antibiotic_resistance ARO:3006202 KPC-77 KPC-77 KPC-78 is a KPC beta-lactamase. KPC-78 antibiotic_resistance ARO:3006203 KPC-78 KPC-78 KPC-79 is a KPC beta-lactamase. KPC-79 antibiotic_resistance ARO:3006204 KPC-79 KPC-79 KPC-80 is a KPC beta-lactamase. KPC-80 antibiotic_resistance ARO:3006205 KPC-80 KPC-80 KPC-81 is a KPC beta-lactamase. KPC-81 antibiotic_resistance ARO:3006206 KPC-81 KPC-81 KPC-82 is a KPC beta-lactamase. KPC-82 antibiotic_resistance ARO:3006207 KPC-82 KPC-82 VEB-11 is a VEB beta-lactamase. VEB-11 antibiotic_resistance ARO:3006208 VEB-11 VEB-11 VEB-12 is a VEB beta-lactamase. VEB-12 antibiotic_resistance ARO:3006209 VEB-12 VEB-12 VEB-13 is a VEB beta-lactamase. VEB-13 antibiotic_resistance ARO:3006210 VEB-13 VEB-13 VEB-14 is a VEB beta-lactamase. VEB-14 antibiotic_resistance ARO:3006211 VEB-14 VEB-14 VEB-15 is a VEB beta-lactamase. VEB-15 antibiotic_resistance ARO:3006212 VEB-15 VEB-15 VEB-17 is a VEB beta-lactamase. VEB-17 antibiotic_resistance ARO:3006213 VEB-17 VEB-17 VEB-19 is a VEB beta-lactamase. VEB-19 antibiotic_resistance ARO:3006214 VEB-19 VEB-19 VEB-20 is a VEB beta-lactamase. VEB-20 antibiotic_resistance ARO:3006215 VEB-20 VEB-20 VEB-21 is a VEB beta-lactamase. VEB-21 antibiotic_resistance ARO:3006216 VEB-21 VEB-21 VEB-22 is a VEB beta-lactamase. VEB-22 antibiotic_resistance ARO:3006217 VEB-22 VEB-22 VEB-23 is a VEB beta-lactamase. VEB-23 antibiotic_resistance ARO:3006218 VEB-23 VEB-23 VEB-24 is a VEB beta-lactamase. VEB-24 antibiotic_resistance ARO:3006219 VEB-24 VEB-24 VEB-25 is a VEB beta-lactamase. VEB-25 antibiotic_resistance ARO:3006220 VEB-25 VEB-25 VEB-26 is a VEB beta-lactamase. VEB-26 antibiotic_resistance ARO:3006221 VEB-26 VEB-26 VEB-27 is a VEB beta-lactamase. VEB-27 antibiotic_resistance ARO:3006222 VEB-27 VEB-27 BKC-2 is a BKC beta-lactamase. BKC-2 antibiotic_resistance ARO:3006223 BKC-2 BKC-2 CepA-29 is a CepA beta-lactamase. CepA-29 antibiotic_resistance ARO:3006224 CepA-29 CepA-29 CepA-44 is a CepA beta-lactamase. CepA-44 antibiotic_resistance ARO:3006225 CepA-44 CepA-44 CepA-49 is a CepA beta-lactamase. CepA-49 antibiotic_resistance ARO:3006226 CepA-49 CepA-49 FRI-10 is a FRI beta-lactamase. FRI-10 antibiotic_resistance ARO:3006227 FRI-10 FRI-10 ACC-1a is a ACC beta-lactamase. ACC-1a antibiotic_resistance ARO:3006228 ACC-1a ACC-1a ACC-1b is a ACC beta-lactamase. ACC-1b antibiotic_resistance ARO:3006229 ACC-1b ACC-1b ACC-1c is a ACC beta-lactamase. ACC-1c antibiotic_resistance ARO:3006230 ACC-1c ACC-1c ACC-1d is a ACC beta-lactamase. ACC-1d antibiotic_resistance ARO:3006231 ACC-1d ACC-1d ACC-7 is a ACC beta-lactamase. ACC-7 antibiotic_resistance ARO:3006232 ACC-7 ACC-7 ACC-8 is a ACC beta-lactamase. ACC-8 antibiotic_resistance ARO:3006233 ACC-8 ACC-8 ACT-39 is a ACT beta-lactamase. ACT-39 antibiotic_resistance ARO:3006234 ACT-39 ACT-39 ACT-40 is a ACT beta-lactamase. ACT-40 antibiotic_resistance ARO:3006235 ACT-40 ACT-40 ACT-41 is a ACT beta-lactamase. ACT-41 antibiotic_resistance ARO:3006236 ACT-41 ACT-41 ACT-42 is a ACT beta-lactamase. ACT-42 antibiotic_resistance ARO:3006237 ACT-42 ACT-42 ACT-43 is a ACT beta-lactamase. ACT-43 antibiotic_resistance ARO:3006238 ACT-43 ACT-43 ACT-44 is a ACT beta-lactamase. ACT-44 antibiotic_resistance ARO:3006239 ACT-44 ACT-44 ACT-45 is a ACT beta-lactamase. ACT-45 antibiotic_resistance ARO:3006240 ACT-45 ACT-45 ACT-46 is a ACT beta-lactamase. ACT-46 antibiotic_resistance ARO:3006241 ACT-46 ACT-46 ACT-47 is a ACT beta-lactamase. ACT-47 antibiotic_resistance ARO:3006242 ACT-47 ACT-47 ACT-48 is a ACT beta-lactamase. ACT-48 antibiotic_resistance ARO:3006243 ACT-48 ACT-48 ACT-49 is a ACT beta-lactamase. ACT-49 antibiotic_resistance ARO:3006244 ACT-49 ACT-49 ACT-50 is a ACT beta-lactamase. ACT-50 antibiotic_resistance ARO:3006245 ACT-50 ACT-50 ACT-51 is a ACT beta-lactamase. ACT-51 antibiotic_resistance ARO:3006246 ACT-51 ACT-51 ACT-52 is a ACT beta-lactamase. ACT-52 antibiotic_resistance ARO:3006247 ACT-52 ACT-52 ACT-53 is a ACT beta-lactamase. ACT-53 antibiotic_resistance ARO:3006248 ACT-53 ACT-53 ACT-54 is a ACT beta-lactamase. ACT-54 antibiotic_resistance ARO:3006249 ACT-54 ACT-54 ACT-55 is a ACT beta-lactamase. ACT-55 antibiotic_resistance ARO:3006250 ACT-55 ACT-55 ACT-56 is a ACT beta-lactamase. ACT-56 antibiotic_resistance ARO:3006251 ACT-56 ACT-56 ACT-57 is a ACT beta-lactamase. ACT-57 antibiotic_resistance ARO:3006252 ACT-57 ACT-57 ACT-58 is a ACT beta-lactamase. ACT-58 antibiotic_resistance ARO:3006253 ACT-58 ACT-58 ACT-59 is a ACT beta-lactamase. ACT-59 antibiotic_resistance ARO:3006254 ACT-59 ACT-59 ACT-60 is a ACT beta-lactamase. ACT-60 antibiotic_resistance ARO:3006255 ACT-60 ACT-60 ACT-61 is a ACT beta-lactamase. ACT-61 antibiotic_resistance ARO:3006256 ACT-61 ACT-61 ACT-62 is a ACT beta-lactamase. ACT-62 antibiotic_resistance ARO:3006257 ACT-62 ACT-62 ACT-63 is a ACT beta-lactamase. ACT-63 antibiotic_resistance ARO:3006258 ACT-63 ACT-63 ACT-64 is a ACT beta-lactamase. ACT-64 antibiotic_resistance ARO:3006259 ACT-64 ACT-64 ACT-65 is a ACT beta-lactamase. ACT-65 antibiotic_resistance ARO:3006260 ACT-65 ACT-65 ACT-66 is a ACT beta-lactamase. ACT-66 antibiotic_resistance ARO:3006261 ACT-66 ACT-66 ACT-67 is a ACT beta-lactamase. ACT-67 antibiotic_resistance ARO:3006262 ACT-67 ACT-67 ACT-68 is a ACT beta-lactamase. ACT-68 antibiotic_resistance ARO:3006263 ACT-68 ACT-68 ACT-69 is a ACT beta-lactamase. ACT-69 antibiotic_resistance ARO:3006264 ACT-69 ACT-69 ACT-70 is a ACT beta-lactamase. ACT-70 antibiotic_resistance ARO:3006265 ACT-70 ACT-70 ACT-72 is a ACT beta-lactamase. ACT-72 antibiotic_resistance ARO:3006266 ACT-72 ACT-72 ACT-73 is a ACT beta-lactamase. ACT-73 antibiotic_resistance ARO:3006267 ACT-73 ACT-73 ACT-74 is a ACT beta-lactamase. ACT-74 antibiotic_resistance ARO:3006268 ACT-74 ACT-74 ACT-75 is a ACT beta-lactamase. ACT-75 antibiotic_resistance ARO:3006269 ACT-75 ACT-75 ACT-76 is a ACT beta-lactamase. ACT-76 antibiotic_resistance ARO:3006270 ACT-76 ACT-76 ACT-77 is a ACT beta-lactamase. ACT-77 antibiotic_resistance ARO:3006271 ACT-77 ACT-77 ACT-78 is a ACT beta-lactamase. ACT-78 antibiotic_resistance ARO:3006272 ACT-78 ACT-78 ACT-79 is a ACT beta-lactamase. ACT-79 antibiotic_resistance ARO:3006273 ACT-79 ACT-79 ACT-80 is a ACT beta-lactamase. ACT-80 antibiotic_resistance ARO:3006274 ACT-80 ACT-80 ACT-81 is a ACT beta-lactamase. ACT-81 antibiotic_resistance ARO:3006275 ACT-81 ACT-81 ACT-82 is a ACT beta-lactamase. ACT-82 antibiotic_resistance ARO:3006276 ACT-82 ACT-82 ACT-83 is a ACT beta-lactamase. ACT-83 antibiotic_resistance ARO:3006277 ACT-83 ACT-83 ACT-84 is a ACT beta-lactamase. ACT-84 antibiotic_resistance ARO:3006278 ACT-84 ACT-84 ACT-87 is a ACT beta-lactamase. ACT-87 antibiotic_resistance ARO:3006279 ACT-87 ACT-87 ADC-100 is a ADC beta-lactamase. ADC-100 antibiotic_resistance ARO:3006280 ADC-100 ADC-100 ADC-101 is a ADC beta-lactamase. ADC-101 antibiotic_resistance ARO:3006281 ADC-101 ADC-101 ADC-102 is a ADC beta-lactamase. ADC-102 antibiotic_resistance ARO:3006282 ADC-102 ADC-102 ADC-103 is a ADC beta-lactamase. ADC-103 antibiotic_resistance ARO:3006283 ADC-103 ADC-103 ADC-104 is a ADC beta-lactamase. ADC-104 antibiotic_resistance ARO:3006284 ADC-104 ADC-104 ADC-105 is a ADC beta-lactamase. ADC-105 antibiotic_resistance ARO:3006285 ADC-105 ADC-105 ADC-106 is a ADC beta-lactamase. ADC-106 antibiotic_resistance ARO:3006286 ADC-106 ADC-106 ADC-107 is a ADC beta-lactamase. ADC-107 antibiotic_resistance ARO:3006287 ADC-107 ADC-107 ADC-109 is a ADC beta-lactamase. ADC-109 antibiotic_resistance ARO:3006288 ADC-109 ADC-109 ADC-110 is a ADC beta-lactamase. ADC-110 antibiotic_resistance ARO:3006289 ADC-110 ADC-110 ADC-112 is a ADC beta-lactamase. ADC-112 antibiotic_resistance ARO:3006290 ADC-112 ADC-112 ADC-113 is a ADC beta-lactamase. ADC-113 antibiotic_resistance ARO:3006291 ADC-113 ADC-113 ADC-114 is a ADC beta-lactamase. ADC-114 antibiotic_resistance ARO:3006292 ADC-114 ADC-114 ADC-115 is a ADC beta-lactamase. ADC-115 antibiotic_resistance ARO:3006293 ADC-115 ADC-115 ADC-116 is a ADC beta-lactamase. ADC-116 antibiotic_resistance ARO:3006294 ADC-116 ADC-116 ADC-117 is a ADC beta-lactamase. ADC-117 antibiotic_resistance ARO:3006295 ADC-117 ADC-117 ADC-119 is a ADC beta-lactamase. ADC-119 antibiotic_resistance ARO:3006296 ADC-119 ADC-119 ADC-120 is a ADC beta-lactamase. ADC-120 antibiotic_resistance ARO:3006297 ADC-120 ADC-120 ADC-121 is a ADC beta-lactamase. ADC-121 antibiotic_resistance ARO:3006298 ADC-121 ADC-121 ADC-122 is a ADC beta-lactamase. ADC-122 antibiotic_resistance ARO:3006299 ADC-122 ADC-122 ADC-123 is a ADC beta-lactamase. ADC-123 antibiotic_resistance ARO:3006300 ADC-123 ADC-123 ADC-125 is a ADC beta-lactamase. ADC-125 antibiotic_resistance ARO:3006301 ADC-125 ADC-125 ADC-127 is a ADC beta-lactamase. ADC-127 antibiotic_resistance ARO:3006302 ADC-127 ADC-127 ADC-128 is a ADC beta-lactamase. ADC-128 antibiotic_resistance ARO:3006303 ADC-128 ADC-128 ADC-129 is a ADC beta-lactamase. ADC-129 antibiotic_resistance ARO:3006304 ADC-129 ADC-129 ADC-130 is a ADC beta-lactamase. ADC-130 antibiotic_resistance ARO:3006305 ADC-130 ADC-130 ADC-131 is a ADC beta-lactamase. ADC-131 antibiotic_resistance ARO:3006306 ADC-131 ADC-131 ADC-132 is a ADC beta-lactamase. ADC-132 antibiotic_resistance ARO:3006307 ADC-132 ADC-132 ADC-133 is a ADC beta-lactamase. ADC-133 antibiotic_resistance ARO:3006308 ADC-133 ADC-133 ADC-134 is a ADC beta-lactamase. ADC-134 antibiotic_resistance ARO:3006309 ADC-134 ADC-134 ADC-135 is a ADC beta-lactamase. ADC-135 antibiotic_resistance ARO:3006310 ADC-135 ADC-135 ADC-136 is a ADC beta-lactamase. ADC-136 antibiotic_resistance ARO:3006311 ADC-136 ADC-136 ADC-137 is a ADC beta-lactamase. ADC-137 antibiotic_resistance ARO:3006312 ADC-137 ADC-137 ADC-138 is a ADC beta-lactamase. ADC-138 antibiotic_resistance ARO:3006313 ADC-138 ADC-138 ADC-139 is a ADC beta-lactamase. ADC-139 antibiotic_resistance ARO:3006314 ADC-139 ADC-139 ADC-140 is a ADC beta-lactamase. ADC-140 antibiotic_resistance ARO:3006315 ADC-140 ADC-140 ADC-141 is a ADC beta-lactamase. ADC-141 antibiotic_resistance ARO:3006316 ADC-141 ADC-141 ADC-143 is a ADC beta-lactamase. ADC-143 antibiotic_resistance ARO:3006317 ADC-143 ADC-143 ADC-144 is a ADC beta-lactamase. ADC-144 antibiotic_resistance ARO:3006318 ADC-144 ADC-144 ADC-145 is a ADC beta-lactamase. ADC-145 antibiotic_resistance ARO:3006319 ADC-145 ADC-145 ADC-146 is a ADC beta-lactamase. ADC-146 antibiotic_resistance ARO:3006320 ADC-146 ADC-146 ADC-147 is a ADC beta-lactamase. ADC-147 antibiotic_resistance ARO:3006321 ADC-147 ADC-147 ADC-148 is a ADC beta-lactamase. ADC-148 antibiotic_resistance ARO:3006322 ADC-148 ADC-148 ADC-149 is a ADC beta-lactamase. ADC-149 antibiotic_resistance ARO:3006323 ADC-149 ADC-149 ADC-150 is a ADC beta-lactamase. ADC-150 antibiotic_resistance ARO:3006324 ADC-150 ADC-150 ADC-151 is a ADC beta-lactamase. ADC-151 antibiotic_resistance ARO:3006325 ADC-151 ADC-151 ADC-152 is a ADC beta-lactamase. ADC-152 antibiotic_resistance ARO:3006326 ADC-152 ADC-152 ADC-153 is a ADC beta-lactamase. ADC-153 antibiotic_resistance ARO:3006327 ADC-153 ADC-153 ADC-154 is a ADC beta-lactamase. ADC-154 antibiotic_resistance ARO:3006328 ADC-154 ADC-154 ADC-155 is a ADC beta-lactamase. ADC-155 antibiotic_resistance ARO:3006329 ADC-155 ADC-155 ADC-156 is a ADC beta-lactamase. ADC-156 antibiotic_resistance ARO:3006330 ADC-156 ADC-156 ADC-157 is a ADC beta-lactamase. ADC-157 antibiotic_resistance ARO:3006331 ADC-157 ADC-157 ADC-158 is a ADC beta-lactamase. ADC-158 antibiotic_resistance ARO:3006332 ADC-158 ADC-158 ADC-160 is a ADC beta-lactamase. ADC-160 antibiotic_resistance ARO:3006333 ADC-160 ADC-160 ADC-162 is a ADC beta-lactamase. ADC-162 antibiotic_resistance ARO:3006334 ADC-162 ADC-162 ADC-163 is a ADC beta-lactamase. ADC-163 antibiotic_resistance ARO:3006335 ADC-163 ADC-163 ADC-164 is a ADC beta-lactamase. ADC-164 antibiotic_resistance ARO:3006336 ADC-164 ADC-164 ADC-165 is a ADC beta-lactamase. ADC-165 antibiotic_resistance ARO:3006337 ADC-165 ADC-165 ADC-166 is a ADC beta-lactamase. ADC-166 antibiotic_resistance ARO:3006338 ADC-166 ADC-166 ADC-167 is a ADC beta-lactamase. ADC-167 antibiotic_resistance ARO:3006339 ADC-167 ADC-167 ADC-168 is a ADC beta-lactamase. ADC-168 antibiotic_resistance ARO:3006340 ADC-168 ADC-168 ADC-169 is a ADC beta-lactamase. ADC-169 antibiotic_resistance ARO:3006341 ADC-169 ADC-169 ADC-170 is a ADC beta-lactamase. ADC-170 antibiotic_resistance ARO:3006342 ADC-170 ADC-170 ADC-171 is a ADC beta-lactamase. ADC-171 antibiotic_resistance ARO:3006343 ADC-171 ADC-171 ADC-172 is a ADC beta-lactamase. ADC-172 antibiotic_resistance ARO:3006344 ADC-172 ADC-172 ADC-173 is a ADC beta-lactamase. ADC-173 antibiotic_resistance ARO:3006345 ADC-173 ADC-173 ADC-174 is a ADC beta-lactamase. ADC-174 antibiotic_resistance ARO:3006346 ADC-174 ADC-174 ADC-175 is a ADC beta-lactamase. ADC-175 antibiotic_resistance ARO:3006347 ADC-175 ADC-175 ADC-176 is a ADC beta-lactamase. ADC-176 antibiotic_resistance ARO:3006348 ADC-176 ADC-176 ADC-177 is a ADC beta-lactamase. ADC-177 antibiotic_resistance ARO:3006349 ADC-177 ADC-177 ADC-178 is a ADC beta-lactamase. ADC-178 antibiotic_resistance ARO:3006350 ADC-178 ADC-178 ADC-179 is a ADC beta-lactamase. ADC-179 antibiotic_resistance ARO:3006351 ADC-179 ADC-179 ADC-180 is a ADC beta-lactamase. ADC-180 antibiotic_resistance ARO:3006352 ADC-180 ADC-180 ADC-184 is a ADC beta-lactamase. ADC-184 antibiotic_resistance ARO:3006353 ADC-184 ADC-184 ADC-185 is a ADC beta-lactamase. ADC-185 antibiotic_resistance ARO:3006354 ADC-185 ADC-185 ADC-186 is a ADC beta-lactamase. ADC-186 antibiotic_resistance ARO:3006355 ADC-186 ADC-186 ADC-187 is a ADC beta-lactamase. ADC-187 antibiotic_resistance ARO:3006356 ADC-187 ADC-187 ADC-188 is a ADC beta-lactamase. ADC-188 antibiotic_resistance ARO:3006357 ADC-188 ADC-188 ADC-189 is a ADC beta-lactamase. ADC-189 antibiotic_resistance ARO:3006358 ADC-189 ADC-189 ADC-190 is a ADC beta-lactamase. ADC-190 antibiotic_resistance ARO:3006359 ADC-190 ADC-190 ADC-191 is a ADC beta-lactamase. ADC-191 antibiotic_resistance ARO:3006360 ADC-191 ADC-191 ADC-192 is a ADC beta-lactamase. ADC-192 antibiotic_resistance ARO:3006361 ADC-192 ADC-192 ADC-193 is a ADC beta-lactamase. ADC-193 antibiotic_resistance ARO:3006362 ADC-193 ADC-193 ADC-194 is a ADC beta-lactamase. ADC-194 antibiotic_resistance ARO:3006363 ADC-194 ADC-194 ADC-195 is a ADC beta-lactamase. ADC-195 antibiotic_resistance ARO:3006364 ADC-195 ADC-195 ADC-196 is a ADC beta-lactamase. ADC-196 antibiotic_resistance ARO:3006365 ADC-196 ADC-196 ADC-197 is a ADC beta-lactamase. ADC-197 antibiotic_resistance ARO:3006366 ADC-197 ADC-197 ADC-198 is a ADC beta-lactamase. ADC-198 antibiotic_resistance ARO:3006367 ADC-198 ADC-198 ADC-199 is a ADC beta-lactamase. ADC-199 antibiotic_resistance ARO:3006368 ADC-199 ADC-199 ADC-200 is a ADC beta-lactamase. ADC-200 antibiotic_resistance ARO:3006369 ADC-200 ADC-200 ADC-201 is a ADC beta-lactamase. ADC-201 antibiotic_resistance ARO:3006370 ADC-201 ADC-201 ADC-202 is a ADC beta-lactamase. ADC-202 antibiotic_resistance ARO:3006371 ADC-202 ADC-202 ADC-203 is a ADC beta-lactamase. ADC-203 antibiotic_resistance ARO:3006372 ADC-203 ADC-203 ADC-204 is a ADC beta-lactamase. ADC-204 antibiotic_resistance ARO:3006373 ADC-204 ADC-204 ADC-205 is a ADC beta-lactamase. ADC-205 antibiotic_resistance ARO:3006374 ADC-205 ADC-205 ADC-206 is a ADC beta-lactamase. ADC-206 antibiotic_resistance ARO:3006375 ADC-206 ADC-206 ADC-207 is a ADC beta-lactamase. ADC-207 antibiotic_resistance ARO:3006376 ADC-207 ADC-207 ADC-208 is a ADC beta-lactamase. ADC-208 antibiotic_resistance ARO:3006377 ADC-208 ADC-208 ADC-209 is a ADC beta-lactamase. ADC-209 antibiotic_resistance ARO:3006378 ADC-209 ADC-209 ADC-210 is a ADC beta-lactamase. ADC-210 antibiotic_resistance ARO:3006379 ADC-210 ADC-210 ADC-211 is a ADC beta-lactamase. ADC-211 antibiotic_resistance ARO:3006380 ADC-211 ADC-211 ADC-212 is a ADC beta-lactamase. ADC-212 antibiotic_resistance ARO:3006381 ADC-212 ADC-212 ADC-213 is a ADC beta-lactamase. ADC-213 antibiotic_resistance ARO:3006382 ADC-213 ADC-213 ADC-214 is a ADC beta-lactamase. ADC-214 antibiotic_resistance ARO:3006383 ADC-214 ADC-214 ADC-215 is a ADC beta-lactamase. ADC-215 antibiotic_resistance ARO:3006384 ADC-215 ADC-215 ADC-216 is a ADC beta-lactamase. ADC-216 antibiotic_resistance ARO:3006385 ADC-216 ADC-216 ADC-217 is a ADC beta-lactamase. ADC-217 antibiotic_resistance ARO:3006386 ADC-217 ADC-217 ADC-218 is a ADC beta-lactamase. ADC-218 antibiotic_resistance ARO:3006387 ADC-218 ADC-218 ADC-219 is a ADC beta-lactamase. ADC-219 antibiotic_resistance ARO:3006388 ADC-219 ADC-219 ADC-220 is a ADC beta-lactamase. ADC-220 antibiotic_resistance ARO:3006389 ADC-220 ADC-220 ADC-221 is a ADC beta-lactamase. ADC-221 antibiotic_resistance ARO:3006390 ADC-221 ADC-221 ADC-222 is a ADC beta-lactamase. ADC-222 antibiotic_resistance ARO:3006391 ADC-222 ADC-222 ADC-223 is a ADC beta-lactamase. ADC-223 antibiotic_resistance ARO:3006392 ADC-223 ADC-223 ADC-224 is a ADC beta-lactamase. ADC-224 antibiotic_resistance ARO:3006393 ADC-224 ADC-224 ADC-225 is a ADC beta-lactamase. ADC-225 antibiotic_resistance ARO:3006394 ADC-225 ADC-225 ADC-226 is a ADC beta-lactamase. ADC-226 antibiotic_resistance ARO:3006395 ADC-226 ADC-226 ADC-227 is a ADC beta-lactamase. ADC-227 antibiotic_resistance ARO:3006396 ADC-227 ADC-227 ADC-228 is a ADC beta-lactamase. ADC-228 antibiotic_resistance ARO:3006397 ADC-228 ADC-228 ADC-229 is a ADC beta-lactamase. ADC-229 antibiotic_resistance ARO:3006398 ADC-229 ADC-229 ADC-230 is a ADC beta-lactamase. ADC-230 antibiotic_resistance ARO:3006399 ADC-230 ADC-230 ADC-231 is a ADC beta-lactamase. ADC-231 antibiotic_resistance ARO:3006400 ADC-231 ADC-231 ADC-232 is a ADC beta-lactamase. ADC-232 antibiotic_resistance ARO:3006401 ADC-232 ADC-232 ADC-233 is a ADC beta-lactamase. ADC-233 antibiotic_resistance ARO:3006402 ADC-233 ADC-233 ADC-234 is a ADC beta-lactamase. ADC-234 antibiotic_resistance ARO:3006403 ADC-234 ADC-234 ADC-235 is a ADC beta-lactamase. ADC-235 antibiotic_resistance ARO:3006404 ADC-235 ADC-235 ADC-236 is a ADC beta-lactamase. ADC-236 antibiotic_resistance ARO:3006405 ADC-236 ADC-236 ADC-237 is a ADC beta-lactamase. ADC-237 antibiotic_resistance ARO:3006406 ADC-237 ADC-237 ADC-238 is a ADC beta-lactamase. ADC-238 antibiotic_resistance ARO:3006407 ADC-238 ADC-238 ADC-239 is a ADC beta-lactamase. ADC-239 antibiotic_resistance ARO:3006408 ADC-239 ADC-239 ADC-24 is a ADC beta-lactamase. ADC-24 antibiotic_resistance ARO:3006409 ADC-24 ADC-24 ADC-240 is a ADC beta-lactamase. ADC-240 antibiotic_resistance ARO:3006410 ADC-240 ADC-240 ADC-241 is a ADC beta-lactamase. ADC-241 antibiotic_resistance ARO:3006411 ADC-241 ADC-241 ADC-242 is a ADC beta-lactamase. ADC-242 antibiotic_resistance ARO:3006412 ADC-242 ADC-242 ADC-243 is a ADC beta-lactamase. ADC-243 antibiotic_resistance ARO:3006413 ADC-243 ADC-243 ADC-244 is a ADC beta-lactamase. ADC-244 antibiotic_resistance ARO:3006414 ADC-244 ADC-244 ADC-245 is a ADC beta-lactamase. ADC-245 antibiotic_resistance ARO:3006415 ADC-245 ADC-245 ADC-246 is a ADC beta-lactamase. ADC-246 antibiotic_resistance ARO:3006416 ADC-246 ADC-246 ADC-247 is a ADC beta-lactamase. ADC-247 antibiotic_resistance ARO:3006417 ADC-247 ADC-247 ADC-248 is a ADC beta-lactamase. ADC-248 antibiotic_resistance ARO:3006418 ADC-248 ADC-248 ADC-249 is a ADC beta-lactamase. ADC-249 antibiotic_resistance ARO:3006419 ADC-249 ADC-249 ADC-250 is a ADC beta-lactamase. ADC-250 antibiotic_resistance ARO:3006420 ADC-250 ADC-250 ADC-251 is a ADC beta-lactamase. ADC-251 antibiotic_resistance ARO:3006421 ADC-251 ADC-251 ADC-252 is a ADC beta-lactamase. ADC-252 antibiotic_resistance ARO:3006422 ADC-252 ADC-252 ADC-253 is a ADC beta-lactamase. ADC-253 antibiotic_resistance ARO:3006423 ADC-253 ADC-253 ADC-254 is a ADC beta-lactamase. ADC-254 antibiotic_resistance ARO:3006424 ADC-254 ADC-254 ADC-255 is a ADC beta-lactamase. ADC-255 antibiotic_resistance ARO:3006425 ADC-255 ADC-255 ADC-256 is a ADC beta-lactamase. ADC-256 antibiotic_resistance ARO:3006426 ADC-256 ADC-256 ADC-29 is a ADC beta-lactamase. ADC-29 antibiotic_resistance ARO:3006427 ADC-29 ADC-29 ADC-32 is a ADC beta-lactamase. ADC-32 antibiotic_resistance ARO:3006428 ADC-32 ADC-32 ADC-33 is a ADC beta-lactamase. ADC-33 antibiotic_resistance ARO:3006429 ADC-33 ADC-33 ADC-38 is a ADC beta-lactamase. ADC-38 antibiotic_resistance ARO:3006430 ADC-38 ADC-38 ADC-51 is a ADC beta-lactamase. ADC-51 antibiotic_resistance ARO:3006431 ADC-51 ADC-51 ADC-52 is a ADC beta-lactamase. ADC-52 antibiotic_resistance ARO:3006432 ADC-52 ADC-52 ADC-53 is a ADC beta-lactamase. ADC-53 antibiotic_resistance ARO:3006433 ADC-53 ADC-53 ADC-54 is a ADC beta-lactamase. ADC-54 antibiotic_resistance ARO:3006434 ADC-54 ADC-54 ADC-57 is a ADC beta-lactamase. ADC-57 antibiotic_resistance ARO:3006435 ADC-57 ADC-57 ADC-63 is a ADC beta-lactamase. ADC-63 antibiotic_resistance ARO:3006436 ADC-63 ADC-63 ADC-65 is a ADC beta-lactamase. ADC-65 antibiotic_resistance ARO:3006437 ADC-65 ADC-65 ADC-66 is a ADC beta-lactamase. ADC-66 antibiotic_resistance ARO:3006438 ADC-66 ADC-66 ADC-70 is a ADC beta-lactamase. ADC-70 antibiotic_resistance ARO:3006439 ADC-70 ADC-70 ADC-83 is a ADC beta-lactamase. ADC-83 antibiotic_resistance ARO:3006440 ADC-83 ADC-83 ADC-84 is a ADC beta-lactamase. ADC-84 antibiotic_resistance ARO:3006441 ADC-84 ADC-84 ADC-85 is a ADC beta-lactamase. ADC-85 antibiotic_resistance ARO:3006442 ADC-85 ADC-85 ADC-86 is a ADC beta-lactamase. ADC-86 antibiotic_resistance ARO:3006443 ADC-86 ADC-86 ADC-87 is a ADC beta-lactamase. ADC-87 antibiotic_resistance ARO:3006444 ADC-87 ADC-87 ADC-88 is a ADC beta-lactamase. ADC-88 antibiotic_resistance ARO:3006445 ADC-88 ADC-88 ADC-89 is a ADC beta-lactamase. ADC-89 antibiotic_resistance ARO:3006446 ADC-89 ADC-89 ADC-90 is a ADC beta-lactamase. ADC-90 antibiotic_resistance ARO:3006447 ADC-90 ADC-90 ADC-91 is a ADC beta-lactamase. ADC-91 antibiotic_resistance ARO:3006448 ADC-91 ADC-91 ADC-92 is a ADC beta-lactamase. ADC-92 antibiotic_resistance ARO:3006449 ADC-92 ADC-92 ADC-93 is a ADC beta-lactamase. ADC-93 antibiotic_resistance ARO:3006450 ADC-93 ADC-93 ADC-94 is a ADC beta-lactamase. ADC-94 antibiotic_resistance ARO:3006451 ADC-94 ADC-94 ADC-95 is a ADC beta-lactamase. ADC-95 antibiotic_resistance ARO:3006452 ADC-95 ADC-95 ADC-96 is a ADC beta-lactamase. ADC-96 antibiotic_resistance ARO:3006453 ADC-96 ADC-96 ADC-97 is a ADC beta-lactamase. ADC-97 antibiotic_resistance ARO:3006454 ADC-97 ADC-97 ADC-98 is a ADC beta-lactamase. ADC-98 antibiotic_resistance ARO:3006455 ADC-98 ADC-98 ADC-99 is a ADC beta-lactamase. ADC-99 antibiotic_resistance ARO:3006456 ADC-99 ADC-99 CMY-137 is a CMY beta-lactamase. CMY-137 antibiotic_resistance ARO:3006457 CMY-137 CMY-137 CMY-159 is a CMY beta-lactamase. CMY-159 antibiotic_resistance ARO:3006458 CMY-159 CMY-159 CMY-167 is a CMY beta-lactamase. CMY-167 antibiotic_resistance ARO:3006459 CMY-167 CMY-167 CMY-168 is a CMY beta-lactamase. CMY-168 antibiotic_resistance ARO:3006460 CMY-168 CMY-168 CMY-169 is a CMY beta-lactamase. CMY-169 antibiotic_resistance ARO:3006461 CMY-169 CMY-169 CMY-170 is a CMY beta-lactamase. CMY-170 antibiotic_resistance ARO:3006462 CMY-170 CMY-170 CMY-174 is a CMY beta-lactamase. CMY-174 antibiotic_resistance ARO:3006463 CMY-174 CMY-174 CMY-8b is a CMY beta-lactamase. CMY-8b antibiotic_resistance ARO:3006464 CMY-8b CMY-8b DHA-24 is a DHA beta-lactamase. DHA-24 antibiotic_resistance ARO:3006465 DHA-24 DHA-24 DHA-25 is a DHA beta-lactamase. DHA-25 antibiotic_resistance ARO:3006466 DHA-25 DHA-25 DHA-26 is a DHA beta-lactamase. DHA-26 antibiotic_resistance ARO:3006467 DHA-26 DHA-26 DHA-27 is a DHA beta-lactamase. DHA-27 antibiotic_resistance ARO:3006468 DHA-27 DHA-27 DHA-28 is a DHA beta-lactamase. DHA-28 antibiotic_resistance ARO:3006469 DHA-28 DHA-28 DHA-29 is a DHA beta-lactamase. DHA-29 antibiotic_resistance ARO:3006470 DHA-29 DHA-29 FOX-13 is a FOX beta-lactamase. FOX-13 antibiotic_resistance ARO:3006471 FOX-13 FOX-13 FOX-14 is a FOX beta-lactamase. FOX-14 antibiotic_resistance ARO:3006472 FOX-14 FOX-14 FOX-15 is a FOX beta-lactamase. FOX-15 antibiotic_resistance ARO:3006473 FOX-15 FOX-15 FOX-16 is a FOX beta-lactamase. FOX-16 antibiotic_resistance ARO:3006474 FOX-16 FOX-16 FOX-17 is a FOX beta-lactamase. FOX-17 antibiotic_resistance ARO:3006475 FOX-17 FOX-17 MOX-12 is a MOX beta-lactamase. MOX-12 antibiotic_resistance ARO:3006477 MOX-12 MOX-12 MOX-13 is a MOX beta-lactamase. MOX-13 antibiotic_resistance ARO:3006478 MOX-13 MOX-13 MOX-14 is a MOX beta-lactamase. MOX-14 antibiotic_resistance ARO:3006479 MOX-14 MOX-14 PDC-100 is a PDC beta-lactamase. PDC-100 antibiotic_resistance ARO:3006480 PDC-100 PDC-100 PDC-101 is a PDC beta-lactamase. PDC-101 antibiotic_resistance ARO:3006481 PDC-101 PDC-101 PDC-102 is a PDC beta-lactamase. PDC-102 antibiotic_resistance ARO:3006482 PDC-102 PDC-102 PDC-103 is a PDC beta-lactamase. PDC-103 antibiotic_resistance ARO:3006483 PDC-103 PDC-103 PDC-106 is a PDC beta-lactamase. PDC-106 antibiotic_resistance ARO:3006484 PDC-106 PDC-106 PDC-107 is a PDC beta-lactamase. PDC-107 antibiotic_resistance ARO:3006485 PDC-107 PDC-107 PDC-108 is a PDC beta-lactamase. PDC-108 antibiotic_resistance ARO:3006486 PDC-108 PDC-108 PDC-109 is a PDC beta-lactamase. PDC-109 antibiotic_resistance ARO:3006487 PDC-109 PDC-109 PDC-110 is a PDC beta-lactamase. PDC-110 antibiotic_resistance ARO:3006488 PDC-110 PDC-110 PDC-111 is a PDC beta-lactamase. PDC-111 antibiotic_resistance ARO:3006489 PDC-111 PDC-111 PDC-112 is a PDC beta-lactamase. PDC-112 antibiotic_resistance ARO:3006490 PDC-112 PDC-112 PDC-113 is a PDC beta-lactamase. PDC-113 antibiotic_resistance ARO:3006491 PDC-113 PDC-113 PDC-114 is a PDC beta-lactamase. PDC-114 antibiotic_resistance ARO:3006492 PDC-114 PDC-114 PDC-115 is a PDC beta-lactamase. PDC-115 antibiotic_resistance ARO:3006493 PDC-115 PDC-115 PDC-116 is a PDC beta-lactamase. PDC-116 antibiotic_resistance ARO:3006494 PDC-116 PDC-116 PDC-12 is a PDC beta-lactamase. PDC-12 antibiotic_resistance ARO:3006495 PDC-12 PDC-12 PDC-120 is a PDC beta-lactamase. PDC-120 antibiotic_resistance ARO:3006496 PDC-120 PDC-120 PDC-121 is a PDC beta-lactamase. PDC-121 antibiotic_resistance ARO:3006497 PDC-121 PDC-121 PDC-122 is a PDC beta-lactamase. PDC-122 antibiotic_resistance ARO:3006498 PDC-122 PDC-122 PDC-123 is a PDC beta-lactamase. PDC-123 antibiotic_resistance ARO:3006499 PDC-123 PDC-123 PDC-124 is a PDC beta-lactamase. PDC-124 antibiotic_resistance ARO:3006500 PDC-124 PDC-124 PDC-125 is a PDC beta-lactamase. PDC-125 antibiotic_resistance ARO:3006501 PDC-125 PDC-125 PDC-126 is a PDC beta-lactamase. PDC-126 antibiotic_resistance ARO:3006502 PDC-126 PDC-126 PDC-127 is a PDC beta-lactamase. PDC-127 antibiotic_resistance ARO:3006503 PDC-127 PDC-127 PDC-128 is a PDC beta-lactamase. PDC-128 antibiotic_resistance ARO:3006504 PDC-128 PDC-128 PDC-129 is a PDC beta-lactamase. PDC-129 antibiotic_resistance ARO:3006505 PDC-129 PDC-129 PDC-13 is a PDC beta-lactamase. PDC-13 antibiotic_resistance ARO:3006506 PDC-13 PDC-13 PDC-130 is a PDC beta-lactamase. PDC-130 antibiotic_resistance ARO:3006507 PDC-130 PDC-130 PDC-131 is a PDC beta-lactamase. PDC-131 antibiotic_resistance ARO:3006508 PDC-131 PDC-131 PDC-132 is a PDC beta-lactamase. PDC-132 antibiotic_resistance ARO:3006509 PDC-132 PDC-132 PDC-133 is a PDC beta-lactamase. PDC-133 antibiotic_resistance ARO:3006510 PDC-133 PDC-133 PDC-134 is a PDC beta-lactamase. PDC-134 antibiotic_resistance ARO:3006511 PDC-134 PDC-134 PDC-135 is a PDC beta-lactamase. PDC-135 antibiotic_resistance ARO:3006512 PDC-135 PDC-135 PDC-136 is a PDC beta-lactamase. PDC-136 antibiotic_resistance ARO:3006513 PDC-136 PDC-136 PDC-137 is a PDC beta-lactamase. PDC-137 antibiotic_resistance ARO:3006514 PDC-137 PDC-137 PDC-138 is a PDC beta-lactamase. PDC-138 antibiotic_resistance ARO:3006515 PDC-138 PDC-138 PDC-139 is a PDC beta-lactamase. PDC-139 antibiotic_resistance ARO:3006516 PDC-139 PDC-139 PDC-140 is a PDC beta-lactamase. PDC-140 antibiotic_resistance ARO:3006517 PDC-140 PDC-140 PDC-141 is a PDC beta-lactamase. PDC-141 antibiotic_resistance ARO:3006518 PDC-141 PDC-141 PDC-142 is a PDC beta-lactamase. PDC-142 antibiotic_resistance ARO:3006519 PDC-142 PDC-142 PDC-143 is a PDC beta-lactamase. PDC-143 antibiotic_resistance ARO:3006520 PDC-143 PDC-143 PDC-144 is a PDC beta-lactamase. PDC-144 antibiotic_resistance ARO:3006521 PDC-144 PDC-144 PDC-145 is a PDC beta-lactamase. PDC-145 antibiotic_resistance ARO:3006522 PDC-145 PDC-145 PDC-146 is a PDC beta-lactamase. PDC-146 antibiotic_resistance ARO:3006523 PDC-146 PDC-146 PDC-147 is a PDC beta-lactamase. PDC-147 antibiotic_resistance ARO:3006524 PDC-147 PDC-147 PDC-148 is a PDC beta-lactamase. PDC-148 antibiotic_resistance ARO:3006525 PDC-148 PDC-148 PDC-149 is a PDC beta-lactamase. PDC-149 antibiotic_resistance ARO:3006526 PDC-149 PDC-149 PDC-15 is a PDC beta-lactamase. PDC-15 antibiotic_resistance ARO:3006527 PDC-15 PDC-15 PDC-150 is a PDC beta-lactamase. PDC-150 antibiotic_resistance ARO:3006528 PDC-150 PDC-150 PDC-151 is a PDC beta-lactamase. PDC-151 antibiotic_resistance ARO:3006529 PDC-151 PDC-151 PDC-152 is a PDC beta-lactamase. PDC-152 antibiotic_resistance ARO:3006530 PDC-152 PDC-152 PDC-153 is a PDC beta-lactamase. PDC-153 antibiotic_resistance ARO:3006531 PDC-153 PDC-153 PDC-154 is a PDC beta-lactamase. PDC-154 antibiotic_resistance ARO:3006532 PDC-154 PDC-154 PDC-155 is a PDC beta-lactamase. PDC-155 antibiotic_resistance ARO:3006533 PDC-155 PDC-155 PDC-156 is a PDC beta-lactamase. PDC-156 antibiotic_resistance ARO:3006534 PDC-156 PDC-156 PDC-157 is a PDC beta-lactamase. PDC-157 antibiotic_resistance ARO:3006535 PDC-157 PDC-157 PDC-158 is a PDC beta-lactamase. PDC-158 antibiotic_resistance ARO:3006536 PDC-158 PDC-158 PDC-159 is a PDC beta-lactamase. PDC-159 antibiotic_resistance ARO:3006537 PDC-159 PDC-159 PDC-16 is a PDC beta-lactamase. PDC-16 antibiotic_resistance ARO:3006538 PDC-16 PDC-16 PDC-160 is a PDC beta-lactamase. PDC-160 antibiotic_resistance ARO:3006539 PDC-160 PDC-160 PDC-161 is a PDC beta-lactamase. PDC-161 antibiotic_resistance ARO:3006540 PDC-161 PDC-161 PDC-162 is a PDC beta-lactamase. PDC-162 antibiotic_resistance ARO:3006541 PDC-162 PDC-162 PDC-163 is a PDC beta-lactamase. PDC-163 antibiotic_resistance ARO:3006542 PDC-163 PDC-163 PDC-164 is a PDC beta-lactamase. PDC-164 antibiotic_resistance ARO:3006543 PDC-164 PDC-164 PDC-165 is a PDC beta-lactamase. PDC-165 antibiotic_resistance ARO:3006544 PDC-165 PDC-165 PDC-166 is a PDC beta-lactamase. PDC-166 antibiotic_resistance ARO:3006545 PDC-166 PDC-166 PDC-167 is a PDC beta-lactamase. PDC-167 antibiotic_resistance ARO:3006546 PDC-167 PDC-167 PDC-168 is a PDC beta-lactamase. PDC-168 antibiotic_resistance ARO:3006547 PDC-168 PDC-168 PDC-169 is a PDC beta-lactamase. PDC-169 antibiotic_resistance ARO:3006548 PDC-169 PDC-169 PDC-17 is a PDC beta-lactamase. PDC-17 antibiotic_resistance ARO:3006549 PDC-17 PDC-17 PDC-170 is a PDC beta-lactamase. PDC-170 antibiotic_resistance ARO:3006550 PDC-170 PDC-170 PDC-171 is a PDC beta-lactamase. PDC-171 antibiotic_resistance ARO:3006551 PDC-171 PDC-171 PDC-172 is a PDC beta-lactamase. PDC-172 antibiotic_resistance ARO:3006552 PDC-172 PDC-172 PDC-174 is a PDC beta-lactamase. PDC-174 antibiotic_resistance ARO:3006553 PDC-174 PDC-174 PDC-175 is a PDC beta-lactamase. PDC-175 antibiotic_resistance ARO:3006554 PDC-175 PDC-175 PDC-176 is a PDC beta-lactamase. PDC-176 antibiotic_resistance ARO:3006555 PDC-176 PDC-176 PDC-177 is a PDC beta-lactamase. PDC-177 antibiotic_resistance ARO:3006556 PDC-177 PDC-177 PDC-178 is a PDC beta-lactamase. PDC-178 antibiotic_resistance ARO:3006557 PDC-178 PDC-178 PDC-179 is a PDC beta-lactamase. PDC-179 antibiotic_resistance ARO:3006558 PDC-179 PDC-179 PDC-18 is a PDC beta-lactamase. PDC-18 antibiotic_resistance ARO:3006559 PDC-18 PDC-18 PDC-180 is a PDC beta-lactamase. PDC-180 antibiotic_resistance ARO:3006560 PDC-180 PDC-180 PDC-181 is a PDC beta-lactamase. PDC-181 antibiotic_resistance ARO:3006561 PDC-181 PDC-181 PDC-182 is a PDC beta-lactamase. PDC-182 antibiotic_resistance ARO:3006562 PDC-182 PDC-182 PDC-184 is a PDC beta-lactamase. PDC-184 antibiotic_resistance ARO:3006563 PDC-184 PDC-184 PDC-185 is a PDC beta-lactamase. PDC-185 antibiotic_resistance ARO:3006564 PDC-185 PDC-185 PDC-186 is a PDC beta-lactamase. PDC-186 antibiotic_resistance ARO:3006565 PDC-186 PDC-186 PDC-187 is a PDC beta-lactamase. PDC-187 antibiotic_resistance ARO:3006566 PDC-187 PDC-187 PDC-188 is a PDC beta-lactamase. PDC-188 antibiotic_resistance ARO:3006567 PDC-188 PDC-188 PDC-189 is a PDC beta-lactamase. PDC-189 antibiotic_resistance ARO:3006568 PDC-189 PDC-189 PDC-190 is a PDC beta-lactamase. PDC-190 antibiotic_resistance ARO:3006569 PDC-190 PDC-190 PDC-191 is a PDC beta-lactamase. PDC-191 antibiotic_resistance ARO:3006570 PDC-191 PDC-191 PDC-192 is a PDC beta-lactamase. PDC-192 antibiotic_resistance ARO:3006571 PDC-192 PDC-192 PDC-193 is a PDC beta-lactamase. PDC-193 antibiotic_resistance ARO:3006572 PDC-193 PDC-193 PDC-194 is a PDC beta-lactamase. PDC-194 antibiotic_resistance ARO:3006573 PDC-194 PDC-194 PDC-195 is a PDC beta-lactamase. PDC-195 antibiotic_resistance ARO:3006574 PDC-195 PDC-195 PDC-196 is a PDC beta-lactamase. PDC-196 antibiotic_resistance ARO:3006575 PDC-196 PDC-196 PDC-197 is a PDC beta-lactamase. PDC-197 antibiotic_resistance ARO:3006576 PDC-197 PDC-197 PDC-198 is a PDC beta-lactamase. PDC-198 antibiotic_resistance ARO:3006577 PDC-198 PDC-198 PDC-199 is a PDC beta-lactamase. PDC-199 antibiotic_resistance ARO:3006578 PDC-199 PDC-199 PDC-20 is a PDC beta-lactamase. PDC-20 antibiotic_resistance ARO:3006579 PDC-20 PDC-20 PDC-200 is a PDC beta-lactamase. PDC-200 antibiotic_resistance ARO:3006580 PDC-200 PDC-200 PDC-202 is a PDC beta-lactamase. PDC-202 antibiotic_resistance ARO:3006581 PDC-202 PDC-202 PDC-203 is a PDC beta-lactamase. PDC-203 antibiotic_resistance ARO:3006582 PDC-203 PDC-203 PDC-204 is a PDC beta-lactamase. PDC-204 antibiotic_resistance ARO:3006583 PDC-204 PDC-204 PDC-205 is a PDC beta-lactamase. PDC-205 antibiotic_resistance ARO:3006584 PDC-205 PDC-205 PDC-206 is a PDC beta-lactamase. PDC-206 antibiotic_resistance ARO:3006585 PDC-206 PDC-206 PDC-208 is a PDC beta-lactamase. PDC-208 antibiotic_resistance ARO:3006586 PDC-208 PDC-208 PDC-209 is a PDC beta-lactamase. PDC-209 antibiotic_resistance ARO:3006587 PDC-209 PDC-209 PDC-210 is a PDC beta-lactamase. PDC-210 antibiotic_resistance ARO:3006588 PDC-210 PDC-210 PDC-211 is a PDC beta-lactamase. PDC-211 antibiotic_resistance ARO:3006589 PDC-211 PDC-211 PDC-213 is a PDC beta-lactamase. PDC-213 antibiotic_resistance ARO:3006590 PDC-213 PDC-213 PDC-214 is a PDC beta-lactamase. PDC-214 antibiotic_resistance ARO:3006591 PDC-214 PDC-214 PDC-215 is a PDC beta-lactamase. PDC-215 antibiotic_resistance ARO:3006592 PDC-215 PDC-215 PDC-216 is a PDC beta-lactamase. PDC-216 antibiotic_resistance ARO:3006593 PDC-216 PDC-216 PDC-217 is a PDC beta-lactamase. PDC-217 antibiotic_resistance ARO:3006594 PDC-217 PDC-217 PDC-218 is a PDC beta-lactamase. PDC-218 antibiotic_resistance ARO:3006595 PDC-218 PDC-218 PDC-219 is a PDC beta-lactamase. PDC-219 antibiotic_resistance ARO:3006596 PDC-219 PDC-219 PDC-21a is a PDC beta-lactamase. PDC-21a antibiotic_resistance ARO:3006597 PDC-21a PDC-21a PDC-21b is a PDC beta-lactamase. PDC-21b antibiotic_resistance ARO:3006598 PDC-21b PDC-21b PDC-22 is a PDC beta-lactamase. PDC-22 antibiotic_resistance ARO:3006599 PDC-22 PDC-22 PDC-220 is a PDC beta-lactamase. PDC-220 antibiotic_resistance ARO:3006600 PDC-220 PDC-220 PDC-221 is a PDC beta-lactamase. PDC-221 antibiotic_resistance ARO:3006601 PDC-221 PDC-221 PDC-222 is a PDC beta-lactamase. PDC-222 antibiotic_resistance ARO:3006602 PDC-222 PDC-222 PDC-223 is a PDC beta-lactamase. PDC-223 antibiotic_resistance ARO:3006603 PDC-223 PDC-223 PDC-224 is a PDC beta-lactamase. PDC-224 antibiotic_resistance ARO:3006604 PDC-224 PDC-224 PDC-226 is a PDC beta-lactamase. PDC-226 antibiotic_resistance ARO:3006605 PDC-226 PDC-226 PDC-227 is a PDC beta-lactamase. PDC-227 antibiotic_resistance ARO:3006606 PDC-227 PDC-227 PDC-228 is a PDC beta-lactamase. PDC-228 antibiotic_resistance ARO:3006607 PDC-228 PDC-228 PDC-229 is a PDC beta-lactamase. PDC-229 antibiotic_resistance ARO:3006608 PDC-229 PDC-229 PDC-230 is a PDC beta-lactamase. PDC-230 antibiotic_resistance ARO:3006609 PDC-230 PDC-230 PDC-232 is a PDC beta-lactamase. PDC-232 antibiotic_resistance ARO:3006610 PDC-232 PDC-232 PDC-233 is a PDC beta-lactamase. PDC-233 antibiotic_resistance ARO:3006611 PDC-233 PDC-233 PDC-234 is a PDC beta-lactamase. PDC-234 antibiotic_resistance ARO:3006612 PDC-234 PDC-234 PDC-235 is a PDC beta-lactamase. PDC-235 antibiotic_resistance ARO:3006613 PDC-235 PDC-235 PDC-236 is a PDC beta-lactamase. PDC-236 antibiotic_resistance ARO:3006614 PDC-236 PDC-236 PDC-237 is a PDC beta-lactamase. PDC-237 antibiotic_resistance ARO:3006615 PDC-237 PDC-237 PDC-238 is a PDC beta-lactamase. PDC-238 antibiotic_resistance ARO:3006616 PDC-238 PDC-238 PDC-239 is a PDC beta-lactamase. PDC-239 antibiotic_resistance ARO:3006617 PDC-239 PDC-239 PDC-24 is a PDC beta-lactamase. PDC-24 antibiotic_resistance ARO:3006618 PDC-24 PDC-24 PDC-241 is a PDC beta-lactamase. PDC-241 antibiotic_resistance ARO:3006619 PDC-241 PDC-241 PDC-242 is a PDC beta-lactamase. PDC-242 antibiotic_resistance ARO:3006620 PDC-242 PDC-242 PDC-243 is a PDC beta-lactamase. PDC-243 antibiotic_resistance ARO:3006621 PDC-243 PDC-243 PDC-244 is a PDC beta-lactamase. PDC-244 antibiotic_resistance ARO:3006622 PDC-244 PDC-244 PDC-245 is a PDC beta-lactamase. PDC-245 antibiotic_resistance ARO:3006623 PDC-245 PDC-245 PDC-246 is a PDC beta-lactamase. PDC-246 antibiotic_resistance ARO:3006624 PDC-246 PDC-246 PDC-247 is a PDC beta-lactamase. PDC-247 antibiotic_resistance ARO:3006625 PDC-247 PDC-247 PDC-248 is a PDC beta-lactamase. PDC-248 antibiotic_resistance ARO:3006626 PDC-248 PDC-248 PDC-249 is a PDC beta-lactamase. PDC-249 antibiotic_resistance ARO:3006627 PDC-249 PDC-249 PDC-25 is a PDC beta-lactamase. PDC-25 antibiotic_resistance ARO:3006628 PDC-25 PDC-25 PDC-250 is a PDC beta-lactamase. PDC-250 antibiotic_resistance ARO:3006629 PDC-250 PDC-250 PDC-251 is a PDC beta-lactamase. PDC-251 antibiotic_resistance ARO:3006630 PDC-251 PDC-251 PDC-252 is a PDC beta-lactamase. PDC-252 antibiotic_resistance ARO:3006631 PDC-252 PDC-252 PDC-253 is a PDC beta-lactamase. PDC-253 antibiotic_resistance ARO:3006632 PDC-253 PDC-253 PDC-254 is a PDC beta-lactamase. PDC-254 antibiotic_resistance ARO:3006633 PDC-254 PDC-254 PDC-256 is a PDC beta-lactamase. PDC-256 antibiotic_resistance ARO:3006634 PDC-256 PDC-256 PDC-259 is a PDC beta-lactamase. PDC-259 antibiotic_resistance ARO:3006635 PDC-259 PDC-259 PDC-26 is a PDC beta-lactamase. PDC-26 antibiotic_resistance ARO:3006636 PDC-26 PDC-26 PDC-260 is a PDC beta-lactamase. PDC-260 antibiotic_resistance ARO:3006637 PDC-260 PDC-260 PDC-261 is a PDC beta-lactamase. PDC-261 antibiotic_resistance ARO:3006638 PDC-261 PDC-261 PDC-262 is a PDC beta-lactamase. PDC-262 antibiotic_resistance ARO:3006639 PDC-262 PDC-262 PDC-263 is a PDC beta-lactamase. PDC-263 antibiotic_resistance ARO:3006640 PDC-263 PDC-263 PDC-265 is a PDC beta-lactamase. PDC-265 antibiotic_resistance ARO:3006641 PDC-265 PDC-265 PDC-266 is a PDC beta-lactamase. PDC-266 antibiotic_resistance ARO:3006642 PDC-266 PDC-266 PDC-267 is a PDC beta-lactamase. PDC-267 antibiotic_resistance ARO:3006643 PDC-267 PDC-267 PDC-268 is a PDC beta-lactamase. PDC-268 antibiotic_resistance ARO:3006644 PDC-268 PDC-268 PDC-270 is a PDC beta-lactamase. PDC-270 antibiotic_resistance ARO:3006645 PDC-270 PDC-270 PDC-271 is a PDC beta-lactamase. PDC-271 antibiotic_resistance ARO:3006646 PDC-271 PDC-271 PDC-273 is a PDC beta-lactamase. PDC-273 antibiotic_resistance ARO:3006647 PDC-273 PDC-273 PDC-274 is a PDC beta-lactamase. PDC-274 antibiotic_resistance ARO:3006648 PDC-274 PDC-274 PDC-275 is a PDC beta-lactamase. PDC-275 antibiotic_resistance ARO:3006649 PDC-275 PDC-275 PDC-276 is a PDC beta-lactamase. PDC-276 antibiotic_resistance ARO:3006650 PDC-276 PDC-276 PDC-277 is a PDC beta-lactamase. PDC-277 antibiotic_resistance ARO:3006651 PDC-277 PDC-277 PDC-278 is a PDC beta-lactamase. PDC-278 antibiotic_resistance ARO:3006652 PDC-278 PDC-278 PDC-279 is a PDC beta-lactamase. PDC-279 antibiotic_resistance ARO:3006653 PDC-279 PDC-279 PDC-280 is a PDC beta-lactamase. PDC-280 antibiotic_resistance ARO:3006654 PDC-280 PDC-280 PDC-281 is a PDC beta-lactamase. PDC-281 antibiotic_resistance ARO:3006655 PDC-281 PDC-281 PDC-282 is a PDC beta-lactamase. PDC-282 antibiotic_resistance ARO:3006656 PDC-282 PDC-282 PDC-283 is a PDC beta-lactamase. PDC-283 antibiotic_resistance ARO:3006657 PDC-283 PDC-283 PDC-286 is a PDC beta-lactamase. PDC-286 antibiotic_resistance ARO:3006658 PDC-286 PDC-286 PDC-287 is a PDC beta-lactamase. PDC-287 antibiotic_resistance ARO:3006659 PDC-287 PDC-287 PDC-288 is a PDC beta-lactamase. PDC-288 antibiotic_resistance ARO:3006660 PDC-288 PDC-288 PDC-289 is a PDC beta-lactamase. PDC-289 antibiotic_resistance ARO:3006661 PDC-289 PDC-289 PDC-290 is a PDC beta-lactamase. PDC-290 antibiotic_resistance ARO:3006662 PDC-290 PDC-290 PDC-291 is a PDC beta-lactamase. PDC-291 antibiotic_resistance ARO:3006663 PDC-291 PDC-291 PDC-294 is a PDC beta-lactamase. PDC-294 antibiotic_resistance ARO:3006664 PDC-294 PDC-294 PDC-295 is a PDC beta-lactamase. PDC-295 antibiotic_resistance ARO:3006665 PDC-295 PDC-295 PDC-296 is a PDC beta-lactamase. PDC-296 antibiotic_resistance ARO:3006666 PDC-296 PDC-296 PDC-297 is a PDC beta-lactamase. PDC-297 antibiotic_resistance ARO:3006667 PDC-297 PDC-297 PDC-298 is a PDC beta-lactamase. PDC-298 antibiotic_resistance ARO:3006668 PDC-298 PDC-298 PDC-299 is a PDC beta-lactamase. PDC-299 antibiotic_resistance ARO:3006669 PDC-299 PDC-299 PDC-30 is a PDC beta-lactamase. PDC-30 antibiotic_resistance ARO:3006670 PDC-30 PDC-30 PDC-300 is a PDC beta-lactamase. PDC-300 antibiotic_resistance ARO:3006671 PDC-300 PDC-300 PDC-301 is a PDC beta-lactamase. PDC-301 antibiotic_resistance ARO:3006672 PDC-301 PDC-301 PDC-302 is a PDC beta-lactamase. PDC-302 antibiotic_resistance ARO:3006673 PDC-302 PDC-302 PDC-303 is a PDC beta-lactamase. PDC-303 antibiotic_resistance ARO:3006674 PDC-303 PDC-303 PDC-304 is a PDC beta-lactamase. PDC-304 antibiotic_resistance ARO:3006675 PDC-304 PDC-304 PDC-305 is a PDC beta-lactamase. PDC-305 antibiotic_resistance ARO:3006676 PDC-305 PDC-305 PDC-307 is a PDC beta-lactamase. PDC-307 antibiotic_resistance ARO:3006677 PDC-307 PDC-307 PDC-308 is a PDC beta-lactamase. PDC-308 antibiotic_resistance ARO:3006678 PDC-308 PDC-308 PDC-309 is a PDC beta-lactamase. PDC-309 antibiotic_resistance ARO:3006679 PDC-309 PDC-309 PDC-31 is a PDC beta-lactamase. PDC-31 antibiotic_resistance ARO:3006680 PDC-31 PDC-31 PDC-310 is a PDC beta-lactamase. PDC-310 antibiotic_resistance ARO:3006681 PDC-310 PDC-310 PDC-311 is a PDC beta-lactamase. PDC-311 antibiotic_resistance ARO:3006682 PDC-311 PDC-311 PDC-312 is a PDC beta-lactamase. PDC-312 antibiotic_resistance ARO:3006683 PDC-312 PDC-312 PDC-314 is a PDC beta-lactamase. PDC-314 antibiotic_resistance ARO:3006684 PDC-314 PDC-314 PDC-315 is a PDC beta-lactamase. PDC-315 antibiotic_resistance ARO:3006685 PDC-315 PDC-315 PDC-316 is a PDC beta-lactamase. PDC-316 antibiotic_resistance ARO:3006686 PDC-316 PDC-316 PDC-317 is a PDC beta-lactamase. PDC-317 antibiotic_resistance ARO:3006687 PDC-317 PDC-317 PDC-318 is a PDC beta-lactamase. PDC-318 antibiotic_resistance ARO:3006688 PDC-318 PDC-318 PDC-319 is a PDC beta-lactamase. PDC-319 antibiotic_resistance ARO:3006689 PDC-319 PDC-319 PDC-32 is a PDC beta-lactamase. PDC-32 antibiotic_resistance ARO:3006690 PDC-32 PDC-32 PDC-320 is a PDC beta-lactamase. PDC-320 antibiotic_resistance ARO:3006691 PDC-320 PDC-320 PDC-321 is a PDC beta-lactamase. PDC-321 antibiotic_resistance ARO:3006692 PDC-321 PDC-321 PDC-322 is a PDC beta-lactamase. PDC-322 antibiotic_resistance ARO:3006693 PDC-322 PDC-322 PDC-325 is a PDC beta-lactamase. PDC-325 antibiotic_resistance ARO:3006694 PDC-325 PDC-325 PDC-326 is a PDC beta-lactamase. PDC-326 antibiotic_resistance ARO:3006695 PDC-326 PDC-326 PDC-327 is a PDC beta-lactamase. PDC-327 antibiotic_resistance ARO:3006696 PDC-327 PDC-327 PDC-328 is a PDC beta-lactamase. PDC-328 antibiotic_resistance ARO:3006697 PDC-328 PDC-328 PDC-329 is a PDC beta-lactamase. PDC-329 antibiotic_resistance ARO:3006698 PDC-329 PDC-329 PDC-33 is a PDC beta-lactamase. PDC-33 antibiotic_resistance ARO:3006699 PDC-33 PDC-33 PDC-330 is a PDC beta-lactamase. PDC-330 antibiotic_resistance ARO:3006700 PDC-330 PDC-330 PDC-331 is a PDC beta-lactamase. PDC-331 antibiotic_resistance ARO:3006701 PDC-331 PDC-331 PDC-332 is a PDC beta-lactamase. PDC-332 antibiotic_resistance ARO:3006702 PDC-332 PDC-332 PDC-333 is a PDC beta-lactamase. PDC-333 antibiotic_resistance ARO:3006703 PDC-333 PDC-333 PDC-334 is a PDC beta-lactamase. PDC-334 antibiotic_resistance ARO:3006704 PDC-334 PDC-334 PDC-335 is a PDC beta-lactamase. PDC-335 antibiotic_resistance ARO:3006705 PDC-335 PDC-335 PDC-336 is a PDC beta-lactamase. PDC-336 antibiotic_resistance ARO:3006706 PDC-336 PDC-336 PDC-338 is a PDC beta-lactamase. PDC-338 antibiotic_resistance ARO:3006707 PDC-338 PDC-338 PDC-339 is a PDC beta-lactamase. PDC-339 antibiotic_resistance ARO:3006708 PDC-339 PDC-339 PDC-34 is a PDC beta-lactamase. PDC-34 antibiotic_resistance ARO:3006709 PDC-34 PDC-34 PDC-340 is a PDC beta-lactamase. PDC-340 antibiotic_resistance ARO:3006710 PDC-340 PDC-340 PDC-341 is a PDC beta-lactamase. PDC-341 antibiotic_resistance ARO:3006711 PDC-341 PDC-341 PDC-342 is a PDC beta-lactamase. PDC-342 antibiotic_resistance ARO:3006712 PDC-342 PDC-342 PDC-343 is a PDC beta-lactamase. PDC-343 antibiotic_resistance ARO:3006713 PDC-343 PDC-343 PDC-344 is a PDC beta-lactamase. PDC-344 antibiotic_resistance ARO:3006714 PDC-344 PDC-344 PDC-345 is a PDC beta-lactamase. PDC-345 antibiotic_resistance ARO:3006715 PDC-345 PDC-345 PDC-347 is a PDC beta-lactamase. PDC-347 antibiotic_resistance ARO:3006716 PDC-347 PDC-347 PDC-348 is a PDC beta-lactamase. PDC-348 antibiotic_resistance ARO:3006717 PDC-348 PDC-348 PDC-349 is a PDC beta-lactamase. PDC-349 antibiotic_resistance ARO:3006718 PDC-349 PDC-349 PDC-35 is a PDC beta-lactamase. PDC-35 antibiotic_resistance ARO:3006719 PDC-35 PDC-35 PDC-350 is a PDC beta-lactamase. PDC-350 antibiotic_resistance ARO:3006720 PDC-350 PDC-350 PDC-351 is a PDC beta-lactamase. PDC-351 antibiotic_resistance ARO:3006721 PDC-351 PDC-351 PDC-353 is a PDC beta-lactamase. PDC-353 antibiotic_resistance ARO:3006722 PDC-353 PDC-353 PDC-354 is a PDC beta-lactamase. PDC-354 antibiotic_resistance ARO:3006723 PDC-354 PDC-354 PDC-355 is a PDC beta-lactamase. PDC-355 antibiotic_resistance ARO:3006724 PDC-355 PDC-355 PDC-356 is a PDC beta-lactamase. PDC-356 antibiotic_resistance ARO:3006725 PDC-356 PDC-356 PDC-357 is a PDC beta-lactamase. PDC-357 antibiotic_resistance ARO:3006726 PDC-357 PDC-357 PDC-358 is a PDC beta-lactamase. PDC-358 antibiotic_resistance ARO:3006727 PDC-358 PDC-358 PDC-359 is a PDC beta-lactamase. PDC-359 antibiotic_resistance ARO:3006728 PDC-359 PDC-359 PDC-36 is a PDC beta-lactamase. PDC-36 antibiotic_resistance ARO:3006729 PDC-36 PDC-36 PDC-360 is a PDC beta-lactamase. PDC-360 antibiotic_resistance ARO:3006730 PDC-360 PDC-360 PDC-361 is a PDC beta-lactamase. PDC-361 antibiotic_resistance ARO:3006731 PDC-361 PDC-361 PDC-362 is a PDC beta-lactamase. PDC-362 antibiotic_resistance ARO:3006732 PDC-362 PDC-362 PDC-363 is a PDC beta-lactamase. PDC-363 antibiotic_resistance ARO:3006733 PDC-363 PDC-363 PDC-364 is a PDC beta-lactamase. PDC-364 antibiotic_resistance ARO:3006734 PDC-364 PDC-364 PDC-365 is a PDC beta-lactamase. PDC-365 antibiotic_resistance ARO:3006735 PDC-365 PDC-365 PDC-366 is a PDC beta-lactamase. PDC-366 antibiotic_resistance ARO:3006736 PDC-366 PDC-366 PDC-367 is a PDC beta-lactamase. PDC-367 antibiotic_resistance ARO:3006737 PDC-367 PDC-367 PDC-368 is a PDC beta-lactamase. PDC-368 antibiotic_resistance ARO:3006738 PDC-368 PDC-368 PDC-369 is a PDC beta-lactamase. PDC-369 antibiotic_resistance ARO:3006739 PDC-369 PDC-369 PDC-37 is a PDC beta-lactamase. PDC-37 antibiotic_resistance ARO:3006740 PDC-37 PDC-37 PDC-370 is a PDC beta-lactamase. PDC-370 antibiotic_resistance ARO:3006741 PDC-370 PDC-370 PDC-371 is a PDC beta-lactamase. PDC-371 antibiotic_resistance ARO:3006742 PDC-371 PDC-371 PDC-372 is a PDC beta-lactamase. PDC-372 antibiotic_resistance ARO:3006743 PDC-372 PDC-372 PDC-373 is a PDC beta-lactamase. PDC-373 antibiotic_resistance ARO:3006744 PDC-373 PDC-373 PDC-374 is a PDC beta-lactamase. PDC-374 antibiotic_resistance ARO:3006745 PDC-374 PDC-374 PDC-375 is a PDC beta-lactamase. PDC-375 antibiotic_resistance ARO:3006746 PDC-375 PDC-375 PDC-377 is a PDC beta-lactamase. PDC-377 antibiotic_resistance ARO:3006747 PDC-377 PDC-377 PDC-378 is a PDC beta-lactamase. PDC-378 antibiotic_resistance ARO:3006748 PDC-378 PDC-378 PDC-379 is a PDC beta-lactamase. PDC-379 antibiotic_resistance ARO:3006749 PDC-379 PDC-379 PDC-38 is a PDC beta-lactamase. PDC-38 antibiotic_resistance ARO:3006750 PDC-38 PDC-38 PDC-381 is a PDC beta-lactamase. PDC-381 antibiotic_resistance ARO:3006751 PDC-381 PDC-381 PDC-382 is a PDC beta-lactamase. PDC-382 antibiotic_resistance ARO:3006752 PDC-382 PDC-382 PDC-383 is a PDC beta-lactamase. PDC-383 antibiotic_resistance ARO:3006753 PDC-383 PDC-383 PDC-385 is a PDC beta-lactamase. PDC-385 antibiotic_resistance ARO:3006754 PDC-385 PDC-385 PDC-386 is a PDC beta-lactamase. PDC-386 antibiotic_resistance ARO:3006755 PDC-386 PDC-386 PDC-387 is a PDC beta-lactamase. PDC-387 antibiotic_resistance ARO:3006756 PDC-387 PDC-387 PDC-388 is a PDC beta-lactamase. PDC-388 antibiotic_resistance ARO:3006757 PDC-388 PDC-388 PDC-389 is a PDC beta-lactamase. PDC-389 antibiotic_resistance ARO:3006758 PDC-389 PDC-389 PDC-39 is a PDC beta-lactamase. PDC-39 antibiotic_resistance ARO:3006759 PDC-39 PDC-39 PDC-390 is a PDC beta-lactamase. PDC-390 antibiotic_resistance ARO:3006760 PDC-390 PDC-390 PDC-391 is a PDC beta-lactamase. PDC-391 antibiotic_resistance ARO:3006761 PDC-391 PDC-391 PDC-392 is a PDC beta-lactamase. PDC-392 antibiotic_resistance ARO:3006762 PDC-392 PDC-392 PDC-394 is a PDC beta-lactamase. PDC-394 antibiotic_resistance ARO:3006763 PDC-394 PDC-394 PDC-395 is a PDC beta-lactamase. PDC-395 antibiotic_resistance ARO:3006764 PDC-395 PDC-395 PDC-396 is a PDC beta-lactamase. PDC-396 antibiotic_resistance ARO:3006765 PDC-396 PDC-396 PDC-397 is a PDC beta-lactamase. PDC-397 antibiotic_resistance ARO:3006766 PDC-397 PDC-397 PDC-398 is a PDC beta-lactamase. PDC-398 antibiotic_resistance ARO:3006767 PDC-398 PDC-398 PDC-399 is a PDC beta-lactamase. PDC-399 antibiotic_resistance ARO:3006768 PDC-399 PDC-399 PDC-40 is a PDC beta-lactamase. PDC-40 antibiotic_resistance ARO:3006769 PDC-40 PDC-40 PDC-400 is a PDC beta-lactamase. PDC-400 antibiotic_resistance ARO:3006770 PDC-400 PDC-400 PDC-401 is a PDC beta-lactamase. PDC-401 antibiotic_resistance ARO:3006771 PDC-401 PDC-401 PDC-402 is a PDC beta-lactamase. PDC-402 antibiotic_resistance ARO:3006772 PDC-402 PDC-402 PDC-403 is a PDC beta-lactamase. PDC-403 antibiotic_resistance ARO:3006773 PDC-403 PDC-403 PDC-404 is a PDC beta-lactamase. PDC-404 antibiotic_resistance ARO:3006774 PDC-404 PDC-404 PDC-405 is a PDC beta-lactamase. PDC-405 antibiotic_resistance ARO:3006775 PDC-405 PDC-405 PDC-406 is a PDC beta-lactamase. PDC-406 antibiotic_resistance ARO:3006776 PDC-406 PDC-406 PDC-407 is a PDC beta-lactamase. PDC-407 antibiotic_resistance ARO:3006777 PDC-407 PDC-407 PDC-408 is a PDC beta-lactamase. PDC-408 antibiotic_resistance ARO:3006778 PDC-408 PDC-408 PDC-409 is a PDC beta-lactamase. PDC-409 antibiotic_resistance ARO:3006779 PDC-409 PDC-409 PDC-410 is a PDC beta-lactamase. PDC-410 antibiotic_resistance ARO:3006780 PDC-410 PDC-410 PDC-411 is a PDC beta-lactamase. PDC-411 antibiotic_resistance ARO:3006781 PDC-411 PDC-411 PDC-412 is a PDC beta-lactamase. PDC-412 antibiotic_resistance ARO:3006782 PDC-412 PDC-412 PDC-414 is a PDC beta-lactamase. PDC-414 antibiotic_resistance ARO:3006783 PDC-414 PDC-414 PDC-415 is a PDC beta-lactamase. PDC-415 antibiotic_resistance ARO:3006784 PDC-415 PDC-415 PDC-416 is a PDC beta-lactamase. PDC-416 antibiotic_resistance ARO:3006785 PDC-416 PDC-416 PDC-417 is a PDC beta-lactamase. PDC-417 antibiotic_resistance ARO:3006786 PDC-417 PDC-417 PDC-418 is a PDC beta-lactamase. PDC-418 antibiotic_resistance ARO:3006787 PDC-418 PDC-418 PDC-419 is a PDC beta-lactamase. PDC-419 antibiotic_resistance ARO:3006788 PDC-419 PDC-419 PDC-42 is a PDC beta-lactamase. PDC-42 antibiotic_resistance ARO:3006789 PDC-42 PDC-42 PDC-420 is a PDC beta-lactamase. PDC-420 antibiotic_resistance ARO:3006790 PDC-420 PDC-420 PDC-421 is a PDC beta-lactamase. PDC-421 antibiotic_resistance ARO:3006791 PDC-421 PDC-421 PDC-422 is a PDC beta-lactamase. PDC-422 antibiotic_resistance ARO:3006792 PDC-422 PDC-422 PDC-423 is a PDC beta-lactamase. PDC-423 antibiotic_resistance ARO:3006793 PDC-423 PDC-423 PDC-424 is a PDC beta-lactamase. PDC-424 antibiotic_resistance ARO:3006794 PDC-424 PDC-424 PDC-425 is a PDC beta-lactamase. PDC-425 antibiotic_resistance ARO:3006795 PDC-425 PDC-425 PDC-426 is a PDC beta-lactamase. PDC-426 antibiotic_resistance ARO:3006796 PDC-426 PDC-426 PDC-427 is a PDC beta-lactamase. PDC-427 antibiotic_resistance ARO:3006797 PDC-427 PDC-427 PDC-428 is a PDC beta-lactamase. PDC-428 antibiotic_resistance ARO:3006798 PDC-428 PDC-428 PDC-430 is a PDC beta-lactamase. PDC-430 antibiotic_resistance ARO:3006799 PDC-430 PDC-430 PDC-431 is a PDC beta-lactamase. PDC-431 antibiotic_resistance ARO:3006800 PDC-431 PDC-431 PDC-432 is a PDC beta-lactamase. PDC-432 antibiotic_resistance ARO:3006801 PDC-432 PDC-432 PDC-433 is a PDC beta-lactamase. PDC-433 antibiotic_resistance ARO:3006802 PDC-433 PDC-433 PDC-434 is a PDC beta-lactamase. PDC-434 antibiotic_resistance ARO:3006803 PDC-434 PDC-434 PDC-435 is a PDC beta-lactamase. PDC-435 antibiotic_resistance ARO:3006804 PDC-435 PDC-435 PDC-436 is a PDC beta-lactamase. PDC-436 antibiotic_resistance ARO:3006805 PDC-436 PDC-436 PDC-437 is a PDC beta-lactamase. PDC-437 antibiotic_resistance ARO:3006806 PDC-437 PDC-437 PDC-439 is a PDC beta-lactamase. PDC-439 antibiotic_resistance ARO:3006807 PDC-439 PDC-439 PDC-440 is a PDC beta-lactamase. PDC-440 antibiotic_resistance ARO:3006808 PDC-440 PDC-440 PDC-441 is a PDC beta-lactamase. PDC-441 antibiotic_resistance ARO:3006809 PDC-441 PDC-441 PDC-442 is a PDC beta-lactamase. PDC-442 antibiotic_resistance ARO:3006810 PDC-442 PDC-442 PDC-443 is a PDC beta-lactamase. PDC-443 antibiotic_resistance ARO:3006811 PDC-443 PDC-443 PDC-444 is a PDC beta-lactamase. PDC-444 antibiotic_resistance ARO:3006812 PDC-444 PDC-444 PDC-445 is a PDC beta-lactamase. PDC-445 antibiotic_resistance ARO:3006813 PDC-445 PDC-445 PDC-446 is a PDC beta-lactamase. PDC-446 antibiotic_resistance ARO:3006814 PDC-446 PDC-446 PDC-447 is a PDC beta-lactamase. PDC-447 antibiotic_resistance ARO:3006815 PDC-447 PDC-447 PDC-448 is a PDC beta-lactamase. PDC-448 antibiotic_resistance ARO:3006816 PDC-448 PDC-448 PDC-450 is a PDC beta-lactamase. PDC-450 antibiotic_resistance ARO:3006817 PDC-450 PDC-450 PDC-451 is a PDC beta-lactamase. PDC-451 antibiotic_resistance ARO:3006818 PDC-451 PDC-451 PDC-452 is a PDC beta-lactamase. PDC-452 antibiotic_resistance ARO:3006819 PDC-452 PDC-452 PDC-453 is a PDC beta-lactamase. PDC-453 antibiotic_resistance ARO:3006820 PDC-453 PDC-453 PDC-454 is a PDC beta-lactamase. PDC-454 antibiotic_resistance ARO:3006821 PDC-454 PDC-454 PDC-455 is a PDC beta-lactamase. PDC-455 antibiotic_resistance ARO:3006822 PDC-455 PDC-455 PDC-456 is a PDC beta-lactamase. PDC-456 antibiotic_resistance ARO:3006823 PDC-456 PDC-456 PDC-457 is a PDC beta-lactamase. PDC-457 antibiotic_resistance ARO:3006824 PDC-457 PDC-457 PDC-458 is a PDC beta-lactamase. PDC-458 antibiotic_resistance ARO:3006825 PDC-458 PDC-458 PDC-459 is a PDC beta-lactamase. PDC-459 antibiotic_resistance ARO:3006826 PDC-459 PDC-459 PDC-46 is a PDC beta-lactamase. PDC-46 antibiotic_resistance ARO:3006827 PDC-46 PDC-46 PDC-460 is a PDC beta-lactamase. PDC-460 antibiotic_resistance ARO:3006828 PDC-460 PDC-460 PDC-462 is a PDC beta-lactamase. PDC-462 antibiotic_resistance ARO:3006829 PDC-462 PDC-462 PDC-463 is a PDC beta-lactamase. PDC-463 antibiotic_resistance ARO:3006830 PDC-463 PDC-463 PDC-465 is a PDC beta-lactamase. PDC-465 antibiotic_resistance ARO:3006831 PDC-465 PDC-465 PDC-466 is a PDC beta-lactamase. PDC-466 antibiotic_resistance ARO:3006832 PDC-466 PDC-466 PDC-467 is a PDC beta-lactamase. PDC-467 antibiotic_resistance ARO:3006833 PDC-467 PDC-467 PDC-468 is a PDC beta-lactamase. PDC-468 antibiotic_resistance ARO:3006834 PDC-468 PDC-468 PDC-469 is a PDC beta-lactamase. PDC-469 antibiotic_resistance ARO:3006835 PDC-469 PDC-469 PDC-470 is a PDC beta-lactamase. PDC-470 antibiotic_resistance ARO:3006836 PDC-470 PDC-470 PDC-471 is a PDC beta-lactamase. PDC-471 antibiotic_resistance ARO:3006837 PDC-471 PDC-471 PDC-472 is a PDC beta-lactamase. PDC-472 antibiotic_resistance ARO:3006838 PDC-472 PDC-472 PDC-473 is a PDC beta-lactamase. PDC-473 antibiotic_resistance ARO:3006839 PDC-473 PDC-473 PDC-474 is a PDC beta-lactamase. PDC-474 antibiotic_resistance ARO:3006840 PDC-474 PDC-474 PDC-475 is a PDC beta-lactamase. PDC-475 antibiotic_resistance ARO:3006841 PDC-475 PDC-475 PDC-476 is a PDC beta-lactamase. PDC-476 antibiotic_resistance ARO:3006842 PDC-476 PDC-476 PDC-58 is a PDC beta-lactamase. PDC-58 antibiotic_resistance ARO:3006843 PDC-58 PDC-58 PDC-60 is a PDC beta-lactamase. PDC-60 antibiotic_resistance ARO:3006844 PDC-60 PDC-60 PDC-64 is a PDC beta-lactamase. PDC-64 antibiotic_resistance ARO:3006845 PDC-64 PDC-64 PDC-71 is a PDC beta-lactamase. PDC-71 antibiotic_resistance ARO:3006846 PDC-71 PDC-71 PDC-94 is a PDC beta-lactamase. PDC-94 antibiotic_resistance ARO:3006847 PDC-94 PDC-94 PDC-95 is a PDC beta-lactamase. PDC-95 antibiotic_resistance ARO:3006848 PDC-95 PDC-95 PDC-96 is a PDC beta-lactamase. PDC-96 antibiotic_resistance ARO:3006849 PDC-96 PDC-96 PDC-97 is a PDC beta-lactamase. PDC-97 antibiotic_resistance ARO:3006850 PDC-97 PDC-97 PDC-98 is a PDC beta-lactamase. PDC-98 antibiotic_resistance ARO:3006851 PDC-98 PDC-98 PDC-99 is a PDC beta-lactamase. PDC-99 antibiotic_resistance ARO:3006852 PDC-99 PDC-99 SRT-3 is a SRT beta-lactamase. SRT-3 antibiotic_resistance ARO:3006853 SRT-3 SRT-3 CMH-2 is a CMH beta-lactamase. CMH-2 antibiotic_resistance ARO:3006854 CMH-2 CMH-2 CMH-3 is a CMH beta-lactamase. CMH-3 antibiotic_resistance ARO:3006855 CMH-3 CMH-3 CMH-4 is a CMH beta-lactamase. CMH-4 antibiotic_resistance ARO:3006856 CMH-4 CMH-4 CMH-5 is a CMH beta-lactamase. CMH-5 antibiotic_resistance ARO:3006857 CMH-5 CMH-5 CMH-6 is a CMH beta-lactamase. CMH-6 antibiotic_resistance ARO:3006858 CMH-6 CMH-6 MIR-19 is a MIR beta-lactamase. MIR-19 antibiotic_resistance ARO:3006859 MIR-19 MIR-19 MIR-20 is a MIR beta-lactamase. MIR-20 antibiotic_resistance ARO:3006860 MIR-20 MIR-20 MIR-21 is a MIR beta-lactamase. MIR-21 antibiotic_resistance ARO:3006861 MIR-21 MIR-21 MIR-22 is a MIR beta-lactamase. MIR-22 antibiotic_resistance ARO:3006862 MIR-22 MIR-22 AAK-1 is a AAK beta-lactamase. AAK-1 antibiotic_resistance ARO:3006863 AAK-1 AAK-1 CRD3-1 is a CRD3 beta-lactamase. CRD3-1 antibiotic_resistance ARO:3006864 CRD3-1 CRD3-1 CRH-1 is a CRH beta-lactamase. CRH-1 antibiotic_resistance ARO:3006865 CRH-1 CRH-1 CRH-2 is a CRH beta-lactamase. CRH-2 antibiotic_resistance ARO:3006866 CRH-2 CRH-2 CRH-3 is a CRH beta-lactamase. CRH-3 antibiotic_resistance ARO:3006867 CRH-3 CRH-3 CRP-1 is a CRP beta-lactamase. CRP-1 antibiotic_resistance ARO:3006868 CRP-1 CRP-1 CSA-1 is a CSA beta-lactamase. CSA-1 antibiotic_resistance ARO:3006869 CSA-1 CSA-1 CSA-2 is a CSA beta-lactamase. CSA-2 antibiotic_resistance ARO:3006870 CSA-2 CSA-2 CSP-1 is a CSP beta-lactamase. CSP-1 antibiotic_resistance ARO:3006871 CSP-1 CSP-1 DHT2-1 is a DHT2 beta-lactamase. DHT2-1 antibiotic_resistance ARO:3006872 DHT2-1 DHT2-1 EAM-1 is a EAM beta-lactamase. EAM-1 antibiotic_resistance ARO:3006873 EAM-1 EAM-1 EC-13 is a EC beta-lactamase. EC-13 antibiotic_resistance ARO:3006874 EC-13 EC-13 EC-14 is a EC beta-lactamase. EC-14 antibiotic_resistance ARO:3006875 EC-14 EC-14 EC-15 is a EC beta-lactamase. EC-15 antibiotic_resistance ARO:3006876 EC-15 EC-15 EC-16 is a EC beta-lactamase. EC-16 antibiotic_resistance ARO:3006877 EC-16 EC-16 EC-18 is a EC beta-lactamase. EC-18 antibiotic_resistance ARO:3006878 EC-18 EC-18 EC-19 is a EC beta-lactamase. EC-19 antibiotic_resistance ARO:3006879 EC-19 EC-19 EC-5 is a EC beta-lactamase. EC-5 antibiotic_resistance ARO:3006880 EC-5 EC-5 EC-8 is a EC beta-lactamase. EC-8 antibiotic_resistance ARO:3006881 EC-8 EC-8 ECM-1 is a ECM beta-lactamase. ECM-1 antibiotic_resistance ARO:3006882 ECM-1 ECM-1 ECV-1 is a ECV beta-lactamase. ECV-1 antibiotic_resistance ARO:3006883 ECV-1 ECV-1 EFM-1 is a EFM beta-lactamase. EFM-1 antibiotic_resistance ARO:3006884 EFM-1 EFM-1 ELM-1 is a ELM beta-lactamase. ELM-1 antibiotic_resistance ARO:3006885 ELM-1 ELM-1 EVM-1 is a EVM beta-lactamase. EVM-1 antibiotic_resistance ARO:3006886 EVM-1 EVM-1 FIA-1 is a FIA beta-lactamase. FIA-1 antibiotic_resistance ARO:3006887 FIA-1 FIA-1 GIL-1 is a GIL beta-lactamase. GIL-1 antibiotic_resistance ARO:3006888 GIL-1 GIL-1 GMB-1 is a GMB beta-lactamase. GMB-1 antibiotic_resistance ARO:3006889 GMB-1 GMB-1 is a GMB beta-lactamase. PMID:35257174 GMB-1 AFM-1 is a AFM beta-lactamase. AFM-1 antibiotic_resistance ARO:3006890 AFM-1 AFM-1 AFM-2 is a AFM beta-lactamase. AFM-2 antibiotic_resistance ARO:3006891 AFM-2 AFM-2 ALG11-1 is a ALG11 beta-lactamase. ALG11-1 antibiotic_resistance ARO:3006892 ALG11-1 ALG11-1 ALG6-1 is a ALG6 beta-lactamase. ALG6-1 antibiotic_resistance ARO:3006893 ALG6-1 ALG6-1 ALI-1 is a ALI beta-lactamase. ALI-1 antibiotic_resistance ARO:3006894 ALI-1 ALI-1 ALI-2 is a ALI beta-lactamase. ALI-2 antibiotic_resistance ARO:3006895 ALI-2 ALI-2 ANA-1 is a ANA beta-lactamase. ANA-1 antibiotic_resistance ARO:3006896 ANA-1 ANA-1 AXC-1 is a AXC beta-lactamase. AXC-1 antibiotic_resistance ARO:3006897 AXC-1 AXC-1 AXC-2 is a AXC beta-lactamase. AXC-2 antibiotic_resistance ARO:3006898 AXC-2 AXC-2 AXC-3 is a AXC beta-lactamase. AXC-3 antibiotic_resistance ARO:3006899 AXC-3 AXC-3 AXC-4 is a AXC beta-lactamase. AXC-4 antibiotic_resistance ARO:3006900 AXC-4 AXC-4 AXC-5 is a AXC beta-lactamase. AXC-5 antibiotic_resistance ARO:3006901 AXC-5 AXC-5 BSU-1 is a BSU beta-lactamase. BSU-1 antibiotic_resistance ARO:3006902 BSU-1 BSU-1 CAR-1 is a CAR beta-lactamase. CAR-1 antibiotic_resistance ARO:3006903 CAR-1 CAR-1 CDD-1 is a CDD beta-lactamase. CDD-1 antibiotic_resistance ARO:3006904 CDD-1 CDD-1 CDD-2 is a CDD beta-lactamase. CDD-2 antibiotic_resistance ARO:3006905 CDD-2 CDD-2 CfiA10 is a CfiA beta-lactamase. CfiA10 antibiotic_resistance ARO:3006906 CfiA10 CfiA10 CfiA11 is a CfiA beta-lactamase. CfiA11 antibiotic_resistance ARO:3006907 CfiA11 CfiA11 CfiA14 is a CfiA beta-lactamase. CfiA14 antibiotic_resistance ARO:3006908 CfiA14 CfiA14 CfiA17 is a CfiA beta-lactamase. CfiA17 antibiotic_resistance ARO:3006909 CfiA17 CfiA17 CfiA18 is a CfiA beta-lactamase. CfiA18 antibiotic_resistance ARO:3006910 CfiA18 CfiA18 CfiA19 is a CfiA beta-lactamase. CfiA19 antibiotic_resistance ARO:3006911 CfiA19 CfiA19 CfiA2 is a CfiA beta-lactamase. CfiA2 antibiotic_resistance ARO:3006912 CfiA2 CfiA2 CfiA21 is a CfiA beta-lactamase. CfiA21 antibiotic_resistance ARO:3006913 CfiA21 CfiA21 CfiA22 is a CfiA beta-lactamase. CfiA22 antibiotic_resistance ARO:3006914 CfiA22 CfiA22 CfiA23 is a CfiA beta-lactamase. CfiA23 antibiotic_resistance ARO:3006915 CfiA23 CfiA23 CfiA24 is a CfiA beta-lactamase. CfiA24 antibiotic_resistance ARO:3006916 CfiA24 CfiA24 CfiA26 is a CfiA beta-lactamase. CfiA26 antibiotic_resistance ARO:3006917 CfiA26 CfiA26 CfiA27 is a CfiA beta-lactamase. CfiA27 antibiotic_resistance ARO:3006918 CfiA27 CfiA27 CfiA4 is a CfiA beta-lactamase. CfiA4 antibiotic_resistance ARO:3006919 CfiA4 CfiA4 CfiA8 is a CfiA beta-lactamase. CfiA8 antibiotic_resistance ARO:3006920 CfiA8 CfiA8 CfiA9 is a CfiA beta-lactamase. CfiA9 antibiotic_resistance ARO:3006921 CfiA9 CfiA9 CMA-1 is a CMA beta-lactamase. CMA-1 antibiotic_resistance ARO:3006922 CMA-1 CMA-1 CMA-2 is a CMA beta-lactamase. CMA-2 antibiotic_resistance ARO:3006923 CMA-2 CMA-2 CVI-1 is a CVI beta-lactamase. CVI-1 antibiotic_resistance ARO:3006924 CVI-1 CVI-1 GRD23-1 is a GRD23 beta-lactamase. GRD23-1 antibiotic_resistance ARO:3006925 GRD23-1 GRD23-1 GRD33-1 is a GRD33 beta-lactamase. GRD33-1 antibiotic_resistance ARO:3006926 GRD33-1 GRD33-1 KLUC-1 is a KLUC beta-lactamase. KLUC-1 antibiotic_resistance ARO:3006927 KLUC-1 KLUC-1 KLUC-2 is a KLUC beta-lactamase. KLUC-2 antibiotic_resistance ARO:3006928 KLUC-2 KLUC-2 KLUC-3 is a KLUC beta-lactamase. KLUC-3 antibiotic_resistance ARO:3006929 KLUC-3 KLUC-3 KLUC-4 is a KLUC beta-lactamase. KLUC-4 antibiotic_resistance ARO:3006930 KLUC-4 KLUC-4 KLUC-5 is a KLUC beta-lactamase. KLUC-5 antibiotic_resistance ARO:3006931 KLUC-5 KLUC-5 LEN-27 is a LEN beta-lactamase. LEN-27 antibiotic_resistance ARO:3006932 LEN-27 LEN-27 LEN-28 is a LEN beta-lactamase. LEN-28 antibiotic_resistance ARO:3006933 LEN-28 LEN-28 LEN-31 is a LEN beta-lactamase. LEN-31 antibiotic_resistance ARO:3006934 LEN-31 LEN-31 LHK-1 is a LHK beta-lactamase. LHK-1 antibiotic_resistance ARO:3006935 LHK-1 LHK-1 LHK-2 is a LHK beta-lactamase. LHK-2 antibiotic_resistance ARO:3006936 LHK-2 LHK-2 LHK-3 is a LHK beta-lactamase. LHK-3 antibiotic_resistance ARO:3006937 LHK-3 LHK-3 LHK-4 is a LHK beta-lactamase. LHK-4 antibiotic_resistance ARO:3006938 LHK-4 LHK-4 LHK-5 is a LHK beta-lactamase. LHK-5 antibiotic_resistance ARO:3006939 LHK-5 LHK-5 LHK-6 is a LHK beta-lactamase. LHK-6 antibiotic_resistance ARO:3006940 LHK-6 LHK-6 LRG-1 is a LRG beta-lactamase. LRG-1 antibiotic_resistance ARO:3006941 LRG-1 LRG-1 LUS-1 is a LUS beta-lactamase. LUS-1 antibiotic_resistance ARO:3006942 LUS-1 LUS-1 LUT-1 is a LUT beta-lactamase. LUT-1 antibiotic_resistance ARO:3006943 LUT-1 LUT-1 LUT-2 is a LUT beta-lactamase. LUT-2 antibiotic_resistance ARO:3006944 LUT-2 LUT-2 LUT-3 is a LUT beta-lactamase. LUT-3 antibiotic_resistance ARO:3006945 LUT-3 LUT-3 LUT-4 is a LUT beta-lactamase. LUT-4 antibiotic_resistance ARO:3006946 LUT-4 LUT-4 LUT-5 is a LUT beta-lactamase. LUT-5 antibiotic_resistance ARO:3006947 LUT-5 LUT-5 LUT-6 is a LUT beta-lactamase. LUT-6 antibiotic_resistance ARO:3006948 LUT-6 LUT-6 MAL-1 is a MAL beta-lactamase. MAL-1 antibiotic_resistance ARO:3006949 MAL-1 MAL-1 MAL-2 is a MAL beta-lactamase. MAL-2 antibiotic_resistance ARO:3006950 MAL-2 MAL-2 MBL1b is a MBL beta-lactamase. MBL1b antibiotic_resistance ARO:3006951 MBL1b MBL1b MOC-1 is a MOC beta-lactamase. MOC-1 antibiotic_resistance ARO:3006952 MOC-1 MOC-1 MOR-2 is a MOR beta-lactamase. MOR-2 antibiotic_resistance ARO:3006953 MOR-2 MOR-2 MYO-1 is a MYO beta-lactamase. MYO-1 antibiotic_resistance ARO:3006954 MYO-1 MYO-1 MYX-1 is a MYX beta-lactamase. MYX-1 antibiotic_resistance ARO:3006955 MYX-1 MYX-1 OHIO-1 is a OHIO beta-lactamase. OHIO-1 antibiotic_resistance ARO:3006956 OHIO-1 OHIO-1 ORN-1 is a ORN beta-lactamase. ORN-1 antibiotic_resistance ARO:3006957 ORN-1 ORN-1 ORN-2 is a ORN beta-lactamase. ORN-2 antibiotic_resistance ARO:3006958 ORN-2 ORN-2 ORN-3 is a ORN beta-lactamase. ORN-3 antibiotic_resistance ARO:3006959 ORN-3 ORN-3 ORN-4 is a ORN beta-lactamase. ORN-4 antibiotic_resistance ARO:3006960 ORN-4 ORN-4 ORN-5 is a ORN beta-lactamase. ORN-5 antibiotic_resistance ARO:3006961 ORN-5 ORN-5 ORN-6 is a ORN beta-lactamase. ORN-6 antibiotic_resistance ARO:3006962 ORN-6 ORN-6 ORR-1 is a ORR beta-lactamase. ORR-1 antibiotic_resistance ARO:3006963 ORR-1 ORR-1 PAU-1 is a PAU beta-lactamase. PAU-1 antibiotic_resistance ARO:3006964 PAU-1 PAU-1 PFM-1 is a PFM beta-lactamase. PFM-1 antibiotic_resistance ARO:3006965 PFM-1 PFM-1 PFM-2 is a PFM beta-lactamase. PFM-2 antibiotic_resistance ARO:3006966 PFM-2 PFM-2 PFM-3 is a PFM beta-lactamase. PFM-3 antibiotic_resistance ARO:3006967 PFM-3 PFM-3 PLA-1 is a PLA beta-lactamase. PLA-1 antibiotic_resistance ARO:3006968 PLA-1 PLA-1 PLA-2a is a PLA beta-lactamase. PLA-2a antibiotic_resistance ARO:3006969 PLA-2a PLA-2a PLA-3 is a PLA beta-lactamase. PLA-3 antibiotic_resistance ARO:3006970 PLA-3 PLA-3 PLA-6 is a PLA beta-lactamase. PLA-6 antibiotic_resistance ARO:3006971 PLA-6 PLA-6 PLN-1 is a PLN beta-lactamase. PLN-1 antibiotic_resistance ARO:3006972 PLN-1 PLN-1 PME-1 is a PME beta-lactamase. PME-1 antibiotic_resistance ARO:3006973 PME-1 PME-1 POM-1 is a POM beta-lactamase. POM-1 antibiotic_resistance ARO:3006974 POM-1 POM-1 POM-2 is a POM beta-lactamase. POM-2 antibiotic_resistance ARO:3006975 POM-2 POM-2 PST-1 is a PST beta-lactamase. PST-1 antibiotic_resistance ARO:3006976 PST-1 PST-1 PST-2 is a PST beta-lactamase. PST-2 antibiotic_resistance ARO:3006977 PST-2 PST-2 PSV-1 is a PSV beta-lactamase. PSV-1 antibiotic_resistance ARO:3006978 PSV-1 PSV-1 RAHN-1 is a RAHN beta-lactamase. RAHN-1 antibiotic_resistance ARO:3006979 RAHN-1 RAHN-1 RAHN-2 is a RAHN beta-lactamase. RAHN-2 antibiotic_resistance ARO:3006980 RAHN-2 RAHN-2 RSA2-1 is a RSA2 beta-lactamase. RSA2-1 antibiotic_resistance ARO:3006981 RSA2-1 RSA2-1 is a RSA2 beta-lactamase. PMID:29316517 RSA2-1 RSD2-1 is a RSD2 beta-lactamase. RSD2-1 antibiotic_resistance ARO:3006982 RSD2-1 RSD2-1 RSD2-2 is a RSD2 beta-lactamase. RSD2-2 antibiotic_resistance ARO:3006983 RSD2-2 RSD2-2 RUB-1 is a RUB beta-lactamase. RUB-1 antibiotic_resistance ARO:3006984 RUB-1 RUB-1 SFC-1 is a SFC beta-lactamase. SFC-1 antibiotic_resistance ARO:3006985 SFC-1 SFC-1 SFO-1 is a SFO beta-lactamase. SFO-1 antibiotic_resistance ARO:3006986 SFO-1 SFO-1 SGM-1 is a SGM beta-lactamase. SGM-1 antibiotic_resistance ARO:3006987 SGM-1 SGM-1 SGM-2 is a SGM beta-lactamase. SGM-2 antibiotic_resistance ARO:3006988 SGM-2 SGM-2 SGM-3 is a SGM beta-lactamase. SGM-3 antibiotic_resistance ARO:3006989 SGM-3 SGM-3 SGM-4 is a SGM beta-lactamase. SGM-4 antibiotic_resistance ARO:3006990 SGM-4 SGM-4 SGM-5 is a SGM beta-lactamase. SGM-5 antibiotic_resistance ARO:3006991 SGM-5 SGM-5 SGM-6 is a SGM beta-lactamase. SGM-6 antibiotic_resistance ARO:3006992 SGM-6 SGM-6 SGM-7 is a SGM beta-lactamase. SGM-7 antibiotic_resistance ARO:3006993 SGM-7 SGM-7 SHN-1 is a SHN beta-lactamase. SHN-1 antibiotic_resistance ARO:3006994 SHN-1 SHN-1 SPN79-1 is a SPN79 beta-lactamase. SPN79-1 antibiotic_resistance ARO:3006995 SPN79-1 SPN79-1 SPR-1 is a SPR beta-lactamase. SPR-1 antibiotic_resistance ARO:3006996 SPR-1 SPR-1 SPS-1 is a SPS beta-lactamase. SPS-1 antibiotic_resistance ARO:3006997 SPS-1 SPS-1 SPU-1 is a SPU beta-lactamase. SPU-1 antibiotic_resistance ARO:3006998 SPU-1 SPU-1 SST-1 is a SST beta-lactamase. SST-1 antibiotic_resistance ARO:3006999 SST-1 SST-1 STA-1 is a STA beta-lactamase. STA-1 antibiotic_resistance ARO:3007000 STA-1 STA-1 TER-1 is a TER beta-lactamase. TER-1 antibiotic_resistance ARO:3007001 TER-1 TER-1 TTU-1 is a TTU beta-lactamase. TTU-1 antibiotic_resistance ARO:3007002 TTU-1 TTU-1 VHH-1 is a VHH beta-lactamase. VHH-1 antibiotic_resistance ARO:3007003 VHH-1 VHH-1 VHW-1 is a VHW beta-lactamase. VHW-1 antibiotic_resistance ARO:3007004 VHW-1 VHW-1 YEM-1 is a YEM beta-lactamase. YEM-1 antibiotic_resistance ARO:3007005 YEM-1 YEM-1 ZOG-1 is a ZOG beta-lactamase. ZOG-1 antibiotic_resistance ARO:3007006 ZOG-1 ZOG-1 TER-2 is a TER beta-lactamase. TER-2 antibiotic_resistance ARO:3007007 TER-2 TER-2 A class of serine beta-lactamase inhibitors. antibiotic_resistance ARO:3007008 diazabicyclooctane An experimental diazabicyclooctane beta-lactamase inhibitor that contains a fluorine atom in place of the carboxamide. pubchem.compound:153516440 antibiotic_resistance ARO:3007009 ANT3310 An experimental diazabicyclooctane beta-lactamase inhibitor that contains a fluorine atom in place of the carboxamide. PMID:33306385 NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR. norC antibiotic_resistance ARO:3007010 norC NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR. PMID:16495280 PMID:23929475 norC mdeA is a multidrug efflux pump that confers resistance in varying degrees to several unrelated antibiotics, including kanamycin, tetracycline, ampicillin, oxacillin, ciprofloxacin, nalidixic acid, acriflavine, and ethidium bromide. mdeA antibiotic_resistance ARO:3007011 mdeA mdeA is a multidrug efflux pump that confers resistance in varying degrees to several unrelated antibiotics, including kanamycin, tetracycline, ampicillin, oxacillin, ciprofloxacin, nalidixic acid, acriflavine, and ethidium bromide. PMID:23462018 mdeA sepA is a multidrug efflux pump that confers resistance to disinfecting agents and dyes. sepA antibiotic_resistance ARO:3007012 sepA sepA is a multidrug efflux pump that confers resistance to disinfecting agents and dyes. PMID:12499635 sepA sdrM encodes an efflux pump that confers resistance to norfloxacin and ethidium bromide, making this a multidrug resistance gene. SA1972 sdrM antibiotic_resistance ARO:3007013 sdrM sdrM encodes an efflux pump that confers resistance to norfloxacin and ethidium bromide, making this a multidrug resistance gene. PMID:16508166 sdrM qacJ is a small multidrug resistance (SMR) efflux pump that confers resistance to quaternary ammonium compounds. qacJ antibiotic_resistance ARO:3007014 qacJ qacJ is a small multidrug resistance (SMR) efflux pump that confers resistance to quaternary ammonium compounds. PMID:14506007 qacJ qacG is a small multidrug resistance efflux pump that confers resistance to benzalkonium chloride and ethidium bromide. qacG antibiotic_resistance ARO:3007015 qacG qacG is a small multidrug resistance efflux pump that confers resistance to benzalkonium chloride and ethidium bromide. PMID:10196743 qacG SHD beta-lactamases are class B1 beta-lactamases found in Shewanella denitrificans. antibiotic_resistance ARO:3007016 SHD beta-lactamase SHD-1 is a SHD beta-lactamase. SHD-1 antibiotic_resistance ARO:3007017 SHD-1 SHD-1 is a SHD beta-lactamase. PMID:29020980 SHD-1 A CARD-specific abbreviation for AMR gene names associated with Antibiotic Resistance Ontology terms, often not based on the literature. This is used for programmatic and compatibility purposes and is not ontologically relevant. Each ontology term with an associated AMR detection model has a CARD Short Name that appears in CARD data files and output generated by RGI. If the original gene name is less than 15 characters, the CARD short name is identical; if the gene name is greater than 15 characters, the CARD Short Name has been abbreviated by CARD curators specifically to identify the proper gene or protein name. All CARD Short Names are unique and have whitespace characters replaced by underscore characters. The convention for pathogen names is capitalized first letter of the genus followed by the lowercase first three letters of the species name. The antibiotic abbreviations are from https://journals.asm.org/journal/aac/abbreviations plus some custom abbreviations by the CARD curators. Simple CARD Short Names often do not involve either, e.g. CTX-M-15, but where applicable the CARD Short Names follow pathogen_gene or pathogen_gene_drug. The full lists of abbreviations can be found in the CARD Downloads: https://card.mcmaster.ca/latest/data. antibiotic_resistance ARO:3007018 CARD Short Name FexB is a plasmid-encoded exporter gene which confers resistance to florfenicol. Originally identified in Enterococcus sp. isolated from swine by Liu et al. 2012. fexB antibiotic_resistance ARO:3007019 fexB FexB is a plasmid-encoded exporter gene which confers resistance to florfenicol. Originally identified in Enterococcus sp. isolated from swine by Liu et al. 2012. PMID:22096043 fexB PFM-4 (BioF) is a class B2 metallo-beta-lactamase first identified in Pseudomonas. It belongs to the PFM-like beta-lactamase gene family. It confers resistance to carbapenems and some cephalosporins. BioF PFM-4 antibiotic_resistance ARO:3007021 PFM-4 PFM-4 (BioF) is a class B2 metallo-beta-lactamase first identified in Pseudomonas. It belongs to the PFM-like beta-lactamase gene family. It confers resistance to carbapenems and some cephalosporins. PMID:34725905 PFM-4 Prulifloxacin is a 6-fluoroquinolone antibiotic with a C-2 sulfur atom. It is hydrolyzed by esterases to produce the active compound Ulifloxacin. The active compound has broad spectrum activity against most Gram-negative bacteria. Prulifloxacin displays strong bactericidal activity against Pseudomonas aeruginosa biofilms and persister cells. pubchem.compound:65947 antibiotic_resistance ARO:3007022 Prulifloxacin Prulifloxacin is a 6-fluoroquinolone antibiotic with a C-2 sulfur atom. It is hydrolyzed by esterases to produce the active compound Ulifloxacin. The active compound has broad spectrum activity against most Gram-negative bacteria. Prulifloxacin displays strong bactericidal activity against Pseudomonas aeruginosa biofilms and persister cells. PMID:1667252 PMID:34905092 PMID:9531524 NDM-33 confers resistance to all beta-lactam antibiotics except aztreonam. It was first identified in an E. coli strain isolated from hospital sewage. It differs from NDM-5 by a single amino acid substitution (A72T). NDM-33 antibiotic_resistance ARO:3007023 NDM-33 NDM-33 confers resistance to all beta-lactam antibiotics except aztreonam. It was first identified in an E. coli strain isolated from hospital sewage. It differs from NDM-5 by a single amino acid substitution (A72T). PMID:34643418 NDM-33 Lascufloxacin is a fluoroquinolone antibiotic. pubchem.compound:71528768 antibiotic_resistance ARO:3007024 Lascufloxacin Lascufloxacin is a fluoroquinolone antibiotic. PMID:28320717 Sarecycline is a tetracycline derivative. pubchem.compound:54681908 antibiotic_resistance ARO:3007025 Sarecycline Sarecycline is a tetracycline derivative. PMID:30397052 salB is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. sal(B) salB antibiotic_resistance ARO:3007026 salB salB is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. PMID:35137182 salB salC is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. sal(C) salC antibiotic_resistance ARO:3007027 salC salC is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. PMID:35137182 salC salD is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. salD antibiotic_resistance ARO:3007028 salD salD is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. PMID:35137182 salD salE is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. sal(E) salE antibiotic_resistance ARO:3007029 salE salE is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. PMID:35137182 salE Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection. antibiotic_resistance ARO:3007030 sal-type ABC-F protein Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection. PMID:35137182 A serine beta-lactamase inhibitor that prevents the degradation of imipenem in the body. pubchem.compound:44129647 antibiotic_resistance ARO:3007031 relebactam Erm(50) is an Erm ribosomal RNA methyltransferase. Erm(50) antibiotic_resistance ARO:3007032 Erm(50) Erm(50) is an Erm ribosomal RNA methyltransferase. PMID:31844016 Erm(50) Erm(51) is an Erm ribosomal RNA methyltransferase. Erm(51) antibiotic_resistance ARO:3007033 Erm(51) Erm(51) is an Erm ribosomal RNA methyltransferase. PMID:32291839 Erm(51) Tetracenomycin antibiotics are aromatic polyketides that inhibit translation by binding to the large ribosomal subunit within the polypeptide exit tunnel. antibiotic_resistance ARO:3007034 tetracenomycin antibiotic Tetracenomycin C is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone. pubchem.compound:73632 antibiotic_resistance ARO:3007035 tetracenomycin C Tetracenomycin C is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone. PMID:11851469 Tetracenomycin X is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone. pubchem.compound:129395 antibiotic_resistance ARO:3007036 tetracenomycin X Tetracenomycin X is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone. PMID:32601485 Tetracenomycin A2 is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone. pubchem.compound:134024 antibiotic_resistance ARO:3007037 tetracenomycin A2 Chlorhexidine is a disinfectant and antiseptic that is used for skin disinfection, including mouthwashes (chlorhexidine gluconate). pubchem.compound:9552079 chlorhexidine acetate chlorhexidine digluconate chlorhexidine gluconate antibiotic_resistance ARO:3007039 chlorhexidine A combination therapy for multidrug resistant pathogens consisting of two cephalosporin antibiotics (cefotaxime and ceftiofur) with two beta-lactamase inhibitors (tazobactam and clavulanate) encapsulated in a nanoparticle. They were shown to have efficient antimicrobial activity against multidrug resistant extended-spectrum beta-lactamase producing Enterobacteriaceae. antibiotic_resistance ARO:3007040 cefotaxime-ceftiofur-tazobactam-clavulanate A combination therapy for multidrug resistant pathogens consisting of two cephalosporin antibiotics (cefotaxime and ceftiofur) with two beta-lactamase inhibitors (tazobactam and clavulanate) encapsulated in a nanoparticle. They were shown to have efficient antimicrobial activity against multidrug resistant extended-spectrum beta-lactamase producing Enterobacteriaceae. PMID:34920071 Erm(52) is an Erm ribosomal RNA methyltransferase. Erm(52) antibiotic_resistance ARO:3007041 Erm(52) Erm(52) is an Erm ribosomal RNA methyltransferase. PMID:33956520 Erm(52) msr(G) is a part of the msr subfamily of ABC-F ribosomal protection proteins. msr(G) msrG antibiotic_resistance ARO:3007042 msr(G) msr(G) is a part of the msr subfamily of ABC-F ribosomal protection proteins. PMID:33118027 msr(G) msr(I) is part of the msr subfamily of ABC-F ribosomal protection proteins. msr(I) msrI antibiotic_resistance ARO:3007043 msr(I) msr(I) mef(F) is an mef efflux pump protein. mef(F) mefF antibiotic_resistance ARO:3007044 mef(F) mef(F) is an mef efflux pump protein. PMID:33118027 mef(F) Enrofloxacin is a broad-spectrum fluoroquinolone antibiotic. It is used in veterinary medicine predominately for dogs and cats but is sometimes used for other animals. pubchem.compound:71188 antibiotic_resistance ARO:3007045 enrofloxacin Enrofloxacin is a broad-spectrum fluoroquinolone antibiotic. It is used in veterinary medicine predominately for dogs and cats but is sometimes used for other animals. PMID:9278889 Marbofloxacin is a broad-spectrum fluoroquinolone antibiotic. It is used in veterinary medicine predominately for dogs and cats. pubchem.compound:60651 antibiotic_resistance ARO:3007046 marbofloxacin mef(H) is an mef efflux pump protein. mef(H) mefH antibiotic_resistance ARO:3007047 mef(H) mef(H) is an mef efflux pump protein. PMID:33956520 mef(H) Xeruborbactam is an experimental cyclic boronate ultrabroad-spectrum beta-lactamase inhibitor, with potent activity against both serine beta-lactamases and metallo-beta-lactamases. pubchem.compound:140830474 QPX7728 antibiotic_resistance ARO:3007048 Xeruborbactam Xeruborbactam is an experimental cyclic boronate ultrabroad-spectrum beta-lactamase inhibitor, with potent activity against both serine beta-lactamases and metallo-beta-lactamases. PMID:34902261 mef(J) is an mef efflux pump protein. mef(J) mefJ antibiotic_resistance ARO:3007049 mef(J) mef(J) mreA is a macrolide efflux pump. mreA antibiotic_resistance ARO:3007050 mreA mreA is a macrolide efflux pump. PMID:9420045 mreA Rifampicin inhibits transcription by binding the beta subunit of RNA polymerase. Helicobacter pylori mutations associated with rifampicin resistance typically occur in the rifampicin resistance determining region of rpoB between codons 525 and 586. Hpyl_rpoB_RIF antibiotic_resistance ARO:3007051 Helicobacter pylori rpoB mutation conferring resistance to rifampicin Rifampicin inhibits transcription by binding the beta subunit of RNA polymerase. Helicobacter pylori mutations associated with rifampicin resistance typically occur in the rifampicin resistance determining region of rpoB between codons 525 and 586. PMID:10348780 PMID:10817737 PMID:17350989 PMID:30774400 PMID:30815255 Hpyl_rpoB_RIF Point mutations in the quinolone resistance-determining regions of Helicobacter pylori observed to confer resistance to fluoroquinolone antibiotics. Hpyl_gyrA_FLO antibiotic_resistance ARO:3007052 Helicobacter pylori gyrA conferring resistance to fluoroquinolones Point mutations in the quinolone resistance-determining regions of Helicobacter pylori observed to confer resistance to fluoroquinolone antibiotics. PMID:21762270 PMID:22064536 PMID:22515359 PMID:25499186 PMID:27809767 PMID:27906990 PMID:28018334 PMID:32471292 PMID:38089809 Hpyl_gyrA_FLO Point mutations in Helicobacter pylori conferring resistance to fluoroquinolone antibiotics. Hpyl_gyrB_FLO antibiotic_resistance ARO:3007053 Helicobacter pylori gyrB conferring resistance to fluoroquinolones Point mutations in Helicobacter pylori conferring resistance to fluoroquinolone antibiotics. PMID:21793912 PMID:22221614 PMID:25003707 PMID:30774400 Hpyl_gyrB_FLO The rdxA gene in Helicobacter pylori encodes an NADPH nitroreductase. Mutations in this gene are associated with metronidazole resistance. Hpyl_rdxA_MTZ antibiotic_resistance ARO:3007055 Helicobacter pylori rdxA mutation conferring resistance to metronidazole The rdxA gene in Helicobacter pylori encodes an NADPH nitroreductase. Mutations in this gene are associated with metronidazole resistance. PMID:10681326 PMID:21801504 PMID:24827414 PMID:27809767 PMID:30621024 PMID:31744181 PMID:32099422 PMID:33593015 PMID:37485536 PMID:9622362 Hpyl_rdxA_MTZ Inactivation of the oxygen-insensitive NADPH nitroreductases in Helicobacter pylori play a role in metronidazole resistance. antibiotic_resistance ARO:3007056 Antibiotic resistant Helicobacter pylori nitroreductase Inactivation of the oxygen-insensitive NADPH nitroreductases in Helicobacter pylori play a role in metronidazole resistance. PMID:11489869 Point mutations in Helicobacter pylori pbp3 observed to confer resistance to amoxicillin. Hpyl_pbp3_AMX antibiotic_resistance ARO:3007057 Helicobacter pylori pbp3 conferring resistance to amoxicillin Point mutations in Helicobacter pylori pbp3 observed to confer resistance to amoxicillin. PMID:18276599 PMID:31801839 Hpyl_pbp3_AMX Point mutations in Helicobacter pylori pbp2 observed to confer resistance to amoxicillin. Hpyl_pbp2_AMX antibiotic_resistance ARO:3007058 Helicobacter pylori pbp2 mutants conferring resistance to amoxicillin Point mutations in Helicobacter pylori pbp2 observed to confer resistance to amoxicillin. PMID:18276599 PMID:31801839 Hpyl_pbp2_AMX FrxA encodes an NADH-flavin oxidoreductase in Helicobacter pylori. Mutations in this gene confer resistance to nitrofuran antibiotics and metronidazole. Hpyl_fxrA_MTZ antibiotic_resistance ARO:3007059 Helicobacter pylori frxA mutation conferring resistance to metronidazole FrxA encodes an NADH-flavin oxidoreductase in Helicobacter pylori. Mutations in this gene confer resistance to nitrofuran antibiotics and metronidazole. PMID:21801504 PMID:25132107 PMID:27809767 PMID:30621024 PMID:32099422 PMID:33593015 Hpyl_fxrA_MTZ Point mutations in Helicobacter pylori pbp1 observed to confer resistance to amoxicillin. Hpyl_pbp1_AMX antibiotic_resistance ARO:3007060 Helicobacter pylori pbp1 mutants conferring resistance to amoxicillin Point mutations in Helicobacter pylori pbp1 observed to confer resistance to amoxicillin. PMID:17951983 PMID:18192681 PMID:31801839 PMID:32545318 PMID:32708761 PMID:35114945 PMID:37485536 Hpyl_pbp1_AMX Hp1165 is a homolog of the Clostridium perfringes tetP gene and is part of the MFS efflux family but is not considered a true tetracycline resistance gene. Hp1165 confers low level resistance to tetracycline, however cessation of antibiotic treatment results in the host cell reverting to susceptibility. antibiotic_resistance ARO:3007061 hp1165 Hp1165 is a homolog of the Clostridium perfringes tetP gene and is part of the MFS efflux family but is not considered a true tetracycline resistance gene. Hp1165 confers low level resistance to tetracycline, however cessation of antibiotic treatment results in the host cell reverting to susceptibility. PMID:16482431 VAM-1 is a subclass B1 metallo-beta-lactamase, conferring resistance to beta-lactam antibiotics such as carbapenems and cephalosporins. VAM-1 VAM1 antibiotic_resistance ARO:3007062 VAM-1 VAM-1 is a subclass B1 metallo-beta-lactamase, conferring resistance to beta-lactam antibiotics such as carbapenems and cephalosporins. PMID:34424042 VAM-1 Cilastatin is often prescribed with imipenem as a beta-lactam potentiator. Cilastatin inhibits enzymatic renal dehydropeptidase, which hydrolyzes imipenem, thereby preventing the metabolism of imipenem in vivo and maintaining longer antibiotic exposure and effect. pubchem.compound:6435415 antibiotic_resistance ARO:3007063 cilastatin VAM beta-lactamases are class B1 beta-lactamases found in Vibrio alginolyticus. antibiotic_resistance ARO:3007065 VAM beta-lactamase Milligrams per Litre (mg/L). antibiotic_resistance ARO:3007066 mg/L Millimeters (mm). antibiotic_resistance ARO:3007067 mm ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification. antibiotic_resistance ARO:3007068 Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins A thiol transferase isolated in Staphylococcus aureus that leads to resistance of fosfomycin. FosY antibiotic_resistance ARO:3007069 FosY A thiol transferase isolated in Staphylococcus aureus that leads to resistance of fosfomycin. PMID:35332834 FosY An MCR-1-type colistin resistance gene variant, first described in a multi-drug-resistant Escherichia coli isolate recovered from a urinary tract infection, and co-occurring with the carbapenemase NDM-5. MCR-1.33 antibiotic_resistance ARO:3007070 MCR-1.33 An MCR-1-type colistin resistance gene variant, first described in a multi-drug-resistant Escherichia coli isolate recovered from a urinary tract infection, and co-occurring with the carbapenemase NDM-5. PMID:35411158 MCR-1.33 An antibiotic-adjuvant admixture of the beta-lactam antibiotic ceftazidime and the non-beta-lactam beta-lactamase inhibitor avibactam. pubchem.compound:77050660 antibiotic_resistance ARO:3007072 ceftazidime-avibactam An antibiotic-adjuvant admixture of the beta-lactam antibiotic ceftazidime and the non-beta-lactam beta-lactamase inhibitor avibactam. PMID:23371303 PMID:29671219 Point mutations that occur within the Bacillus subtilis rpoB gene resulting in resistance to rifampin. Bsub_rpoB_RIF antibiotic_resistance ARO:3007073 Bacillus subtilis rpoB mutants conferring resistance to rifampin Point mutations that occur within the Bacillus subtilis rpoB gene resulting in resistance to rifampin. PMID:11101662 PMID:12169622 PMID:7657605 Bsub_rpoB_RIF Capreomycin family of phosphotransferases confer resistance to capreomycin antibiotics. antibiotic_resistance ARO:3007074 capreomycin phosphotransferase Capreomycin family of phosphotransferases confer resistance to capreomycin antibiotics. PMID:6163840 cph is a phosphotransferase that confers resistance to capreomycin. cph antibiotic_resistance ARO:3007075 cph cph is a phosphotransferase that confers resistance to capreomycin. PMID:34994196 PMID:6163840 cph A fungal secondary metabolite which inhibits the action of New Delhi metallo-beta-lactamase 1. pubchem.compound:146683214 antibiotic_resistance ARO:3007076 emerione A A fungal secondary metabolite which inhibits the action of New Delhi metallo-beta-lactamase 1. PMID:35017068 Molecules and compounds that decrease resistance by inhibiting the action of the MrsA efflux pump. antibiotic_resistance ARO:3007077 inhibitors of MsrA efflux pump Luteolin is a flavonoid produced by a variety of plants that features a wide range of biological effects. It has been shown to inhibit the action of the MsrA drug efflux pump. pubchem.compound:5280445 3',4',5,7-Tetrahydroxyflavone Digitoflavone Luteolol antibiotic_resistance ARO:3007078 Luteolin Luteolin is a flavonoid produced by a variety of plants that features a wide range of biological effects. It has been shown to inhibit the action of the MsrA drug efflux pump. PMID:18991571 PMID:35012652 Pellitorine is a metabolite produced mainly in members of the Zanthoxylum, Tetradium, and Piper genera. It has been shown to inhibit the action of the MsrA drug efflux pump. pubchem.compound:5318516 Pellitorin antibiotic_resistance ARO:3007079 Pellitorine Pellitorine is a metabolite produced mainly in members of the Zanthoxylum, Tetradium, and Piper genera. It has been shown to inhibit the action of the MsrA drug efflux pump. PMID:32449250 Piperic acid is a compound produced by members of the Piper genus. It has been shown to inhibit the action of the MsrA drug efflux pump. pubchem.compound:5370536 Piperonic acid antibiotic_resistance ARO:3007080 Piperic acid Piperic acid is a compound produced by members of the Piper genus. It has been shown to inhibit the action of the MsrA drug efflux pump. PMID:32449250 Tetraydropiperine is a derivative of piperine produced by members of the Piper genus. It has been shown to inhibit the action of the MsrA drug efflux pump. pubchem.compound:581676 Cosmoperine Tetrahydropiperin antibiotic_resistance ARO:3007081 Tetrahydropiperine Tetraydropiperine is a derivative of piperine produced by members of the Piper genus. It has been shown to inhibit the action of the MsrA drug efflux pump. PMID:32449250 Sesamin is a compound isolated from sesame oil and bark from plants in the Zanthoxylum genus. It has been shown to inhibit the action of the MsrA drug efflux pump. pubchem.compound:72307 Asarinin Episesamin Fagarol Fsesamin Pseudocubebin Sezamin antibiotic_resistance ARO:3007082 Sesamin Sesamin is a compound isolated from sesame oil and bark from plants in the Zanthoxylum genus. It has been shown to inhibit the action of the MsrA drug efflux pump. PMID:32449250 Biapenem is a broad spectrum injectable antibiotic belonging to the carbapenem subgroup of beta-lactams. pubchem.compound:71339 Biapenern Bipenem Omegacin antibiotic_resistance ARO:3007083 biapenem Biapenem is a broad spectrum injectable antibiotic belonging to the carbapenem subgroup of beta-lactams. PMID:12381221 PMID:8031067 PRC beta-lactamases are class C beta-lactamases. antibiotic_resistance ARO:3007084 PRC beta-lactamase PRC beta-lactamases are class C beta-lactamases. PMID:34975778 PRC-1 is a beta-lactamase that confers resistance to certain cephalosporins and penicillins. PRC-1 antibiotic_resistance ARO:3007085 PRC-1 PRC-1 is a beta-lactamase that confers resistance to certain cephalosporins and penicillins. PMID:34975778 PRC-1 Epinecidin-1 is a peptide antibiotic derived from Epinephelus coioides with broad spectrum activity against a range or Gram positive and Gram negative bacteria. pubchem.compound:49769423 antibiotic_resistance ARO:3007086 epinecidin-1 Epinecidin-1 is a peptide antibiotic derived from Epinephelus coioides with broad spectrum activity against a range or Gram positive and Gram negative bacteria. PMID:17570764 KPC-90 is a KPC beta-lactamase. KPC-90 antibiotic_resistance ARO:3007087 KPC-90 KPC-90 is a KPC beta-lactamase. PMID:35019766 KPC-90 A peptidomimetic antibiotic with specific, potent action against members of the Pseudomonas genus. Murepavadin disrupts lipopolysaccharide biosynthesis by binding to lypopolysaccharide transport protein D. pubchem.compound:91824766 POL7080 antibiotic_resistance ARO:3007088 murepavadin A peptidomimetic antibiotic with specific, potent action against members of the Pseudomonas genus. Murepavadin disrupts lipopolysaccharide biosynthesis by binding to lypopolysaccharide transport protein D. PMID:20167788 PMID:33367642 KPC-83 is a KPC beta-lactamase. Sequence data were made available through NCBI without publication. KPC-83 antibiotic_resistance ARO:3007089 KPC-83 KPC-83 Albendazole is a compound used in the treatment of parasitic worm infestations. It has been shown to exhibit antibiotic activity against Escherichia coli by inhibiting MurA (MurZ), thereby disrupting cell wall synthesis. pubchem.compound:2082 Albendazol Albendazolum Albenza Bilutac Eskazole Proftril Valbazen Zentel antibiotic_resistance ARO:3007090 albendazole Albendazole is a compound used in the treatment of parasitic worm infestations. It has been shown to exhibit antibiotic activity against Escherichia coli by inhibiting MurA (MurZ), thereby disrupting cell wall synthesis. PMID:35453279 Diflunisal is a salicylic acid derivative and aspirin analogue typically used as a nonsteroidal anti-inflammatory drug. It has been shown to exhibit antibiotic activity against Escherichia coli by inhibiting MurA (MurZ), thereby disrupting cell wall synthesis. pubchem.compound:3059 Adomal Dolobid Dolobis Flovacil Fluniget Fluodonil Flustar antibiotic_resistance ARO:3007091 diflunisal Diflunisal is a salicylic acid derivative and aspirin analogue typically used as a nonsteroidal anti-inflammatory drug. It has been shown to exhibit antibiotic activity against Escherichia coli by inhibiting MurA (MurZ), thereby disrupting cell wall synthesis. PMID:35453279 Gepotidacin is a triazaacenaphthylene bacterial type II topoisomerase inhibitor used experimentally. It has been in phase III of clinical trials since 2019 for the treatment of gonorrhea, however gepotidacin has demonstrated antibiotic activity against a variety of bacteria. pubchem.compound:25101874 antibiotic_resistance ARO:3007092 gepotidacin Gepotidacin is a triazaacenaphthylene bacterial type II topoisomerase inhibitor used experimentally. It has been in phase III of clinical trials since 2019 for the treatment of gonorrhea, however gepotidacin has demonstrated antibiotic activity against a variety of bacteria. PMID:26729499 Klebsidin is a peptide antibiotic derived from Klebsiella pneumoniae that exhibits activity against members of the Enterobacteriaceae family of Gram-negative bacteria, including Escherichia and Salmonella species. Klebsidin acts by accumulating in the target cell and inhibiting RNA polymerase. pubchem.compound:146684527 antibiotic_resistance ARO:3007093 klebsidin Klebsidin is a peptide antibiotic derived from Klebsiella pneumoniae that exhibits activity against members of the Enterobacteriaceae family of Gram-negative bacteria, including Escherichia and Salmonella species. Klebsidin acts by accumulating in the target cell and inhibiting RNA polymerase. PMID:35315272 Fisetin is a flavonoid produced mainly by plants in the Eudicotidae clade. It exhibits a range of biological activities such as anti-inflammatory and antioxidant properties, and fisetin has been shown to inhibit the action of metallo-beta-lactamases. pubchem.compound:5281614 Cotinin Fustel Viset antibiotic_resistance ARO:3007094 fisetin Fisetin is a flavonoid produced mainly by plants in the Eudicotidae clade. It exhibits a range of biological activities such as anti-inflammatory and antioxidant properties, and fisetin has been shown to inhibit the action of metallo-beta-lactamases. PMID:35101651 Risedronate is a bisphosphonate used as an oral medication to treat osteoperosis and Paget's disease of bone. It has been shown to inhibit the action of New Delhi metallo-beta-lactamase-1. pubchem.compound:5245 Actonel Atelvia Benet Risedronic acid antibiotic_resistance ARO:3007095 risedronate Risedronate is a bisphosphonate used as an oral medication to treat osteoperosis and Paget's disease of bone. It has been shown to inhibit the action of New Delhi metallo-beta-lactamase-1. PMID:35209073 Methotrexate is an antifolate chemotherapeutic and immune suppressant used to treat a wide variety of cancers and autoimmune diseases. It has been shown to inhibit the action of New Delhi metallo-beta-lactamase-1. pubchem.compound:126941 Otrexup Rheumatrex Trexall antibiotic_resistance ARO:3007096 methotrexate Methotrexate is an antifolate chemotherapeutic and immune suppressant used to treat a wide variety of cancers and autoimmune diseases. It has been shown to inhibit the action of New Delhi metallo-beta-lactamase-1. PMID:35209073 FosM1 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin. FosM1 antibiotic_resistance ARO:3007097 FosM1 FosM1 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin. PMID:33199384 FosM1 FosM2 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin. FosM2 antibiotic_resistance ARO:3007098 FosM2 FosM2 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin. PMID:33199384 FosM2 FosM3 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin. FosM3 antibiotic_resistance ARO:3007099 FosM3 FosM3 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin. PMID:33199384 FosM3 Class A Bacillus cereus Bc beta-lactamases are enzymes that break down beta-lactam antibiotics, particularly penicillins. antibiotic_resistance ARO:3007100 class A Bacillus cereus Bc beta-lactamase Class A Bacillus cereus Bc beta-lactamases are enzymes that break down beta-lactam antibiotics, particularly penicillins. PMID:29551437 Bacillus cereus beta-lactamase III is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in Bacillus cereus. BcIII antibiotic_resistance ARO:3007101 BcIII Bacillus cereus beta-lactamase III is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in Bacillus cereus. PMID:29551437 BcIII KPC-93 is a KPC beta-lactamase. KPC-93 antibiotic_resistance ARO:3007102 KPC-93 KPC-93 Nitroimidazole reductases are a group of enzymes that deactivate nitroimidazole antibiotics by reducing their nitro functional group to an amino group. These enzymes are associated with resistance to nitroimidazole derivatives in Bacteroides fragilis but have also been reported in a variety of anaerobic Gram-negative and Gram-positive genera. The minimum inhibitory concentrations for these enzymes vary greatly depending on species, strain, and precise nitroimidazole treatment used. antibiotic_resistance ARO:3007103 nitroimidazole reductase Nitroimidazole reductases are a group of enzymes that deactivate nitroimidazole antibiotics by reducing their nitro functional group to an amino group. These enzymes are associated with resistance to nitroimidazole derivatives in Bacteroides fragilis but have also been reported in a variety of anaerobic Gram-negative and Gram-positive genera. The minimum inhibitory concentrations for these enzymes vary greatly depending on species, strain, and precise nitroimidazole treatment used. PMID:10970359 PMID:30316817 nimA is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimA antibiotic_resistance ARO:3007104 nimA nimA is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:10970359 PMID:8067736 nimA nimC is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimC antibiotic_resistance ARO:3007105 nimC nimC is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:10970359 PMID:7773395 nimC nimD is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimD antibiotic_resistance ARO:3007106 nimD nimD is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:10970359 PMID:7773395 nimD nimE is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimE antibiotic_resistance ARO:3007107 nimE nimE is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:10970359 PMID:15273153 nimE nimF is a nitroimidazole reductase that shares significant identity with other nim genes which are associated with the deactivation of nitroimidazole antibiotics. nimF antibiotic_resistance ARO:3007108 nimF nimF is a nitroimidazole reductase that shares significant identity with other nim genes which are associated with the deactivation of nitroimidazole antibiotics. PMID:15728943 nimF nimG is a nitroimidazole reductase that shares significant identity with other nim genes which are associated with the deactivation of nitroimidazole antibiotics. nimG antibiotic_resistance ARO:3007109 nimG nimG is a nitroimidazole reductase that shares significant identity with other nim genes which are associated with the deactivation of nitroimidazole antibiotics. PMID:15190033 nimG nimH is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimH antibiotic_resistance ARO:3007110 nimH nimH is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:28535278 nimH nimI is a nitroimidazole reductase discovered in the Prevotella baroniae that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Although not found in Bacteroids fragilis, the source organism of most nim genes, nimI shares significant similarity with other nitroimidazole reductases. nimI is chromosomally encoded in P. baroniae, suggesting that it is intrinsic to this species. nimI antibiotic_resistance ARO:3007111 nimI nimI is a nitroimidazole reductase discovered in the Prevotella baroniae that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Although not found in Bacteroids fragilis, the source organism of most nim genes, nimI shares significant similarity with other nitroimidazole reductases. nimI is chromosomally encoded in P. baroniae, suggesting that it is intrinsic to this species. PMID:19805556 nimI nimJ is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimJ antibiotic_resistance ARO:3007112 nimJ nimJ is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:23716049 nimJ nimK is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimK antibiotic_resistance ARO:3007113 nimK nimK is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:29982676 nimK Ornidazole is a synthetic nitroimidazole derivative mainly used to treat parasitic infections but has also demonstrated antibiotic activity against anaerobic bacteria. pubchem.compound:28061 antibiotic_resistance ARO:3007114 ornidazole Ornidazole is a synthetic nitroimidazole derivative mainly used to treat parasitic infections but has also demonstrated antibiotic activity against anaerobic bacteria. PMID:18220342 PMID:1863621 Antibiotic-induced changes to cell morphology, including shape, volume and surface area, which decrease antibiotic susceptibility. antibiotic_resistance ARO:3007115 modification to cell morphology Antibiotic-induced changes to cell morphology, including shape, volume and surface area, which decrease antibiotic susceptibility. PMID:35616332 Changes to cell morphology by activated growth response in the presence of an antibiotic, leading to a decreased surface-to-volume ratio. Such changes decrease antibiotic influx and increase antibiotic dilution in the cell, thereby increasing survivability, particularly in nutrient-poor environments. antibiotic_resistance ARO:3007116 Reduction in surface-to-volume ratio of cell Changes to cell morphology by activated growth response in the presence of an antibiotic, leading to a decreased surface-to-volume ratio. Such changes decrease antibiotic influx and increase antibiotic dilution in the cell, thereby increasing survivability, particularly in nutrient-poor environments. PMID:35616332 Subclass B1 Bacteroides xylanisolvens crx beta-lactamases are zinc metallo-beta-lactamases that hydrolyze carbapenems. antibiotic_resistance ARO:3007117 subclass B1 Bacteroides xylanisolvens crx beta-lactamase Subclass B1 Bacteroides xylanisolvens crx beta-lactamases are zinc metallo-beta-lactamases that hydrolyze carbapenems. PMID:35296904 crxA is a subclass B1 metallo-betal-lactamase from Bacteroides xylanisolvens that hydrolyzes carbapenems such as imipenem and meropenem. crxA antibiotic_resistance ARO:3007118 crxA crxA is a subclass B1 metallo-betal-lactamase from Bacteroides xylanisolvens that hydrolyzes carbapenems such as imipenem and meropenem. PMID:35296904 crxA Tet(O/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(O/32/O) antibiotic_resistance ARO:3007119 tet(O/32/O) Tet(O/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:11600392 tet(O/32/O) Tet(O/M/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(O/M/O) antibiotic_resistance ARO:3007120 tet(O/M/O) Tet(O/M/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:15470128 tet(O/M/O) Tet(O/W) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(O/W) antibiotic_resistance ARO:3007121 tet(O/W) Tet(O/W) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:15184185 tet(O/W) Tet(O/W/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(O/W/32/O) antibiotic_resistance ARO:3007122 tet(O/W/32/O) Tet(O/W/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:17967912 tet(O/W/32/O) Tet(O/W/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(O/W/O) antibiotic_resistance ARO:3007123 tet(O/W/O) Tet(O/W/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:12839756 tet(O/W/O) Tet(W/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(W/32/O) antibiotic_resistance ARO:3007124 tet(W/32/O) Tet(W/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:11959557 tet(W/32/O) ROB-11 is a class A beta-lactamase from the blaROB AMR gene family. ROB-11 antibiotic_resistance ARO:3007125 ROB-11 ROB-11 ROB-12 is a class A beta-lactamase from the blaROB AMR gene family. ROB-12 antibiotic_resistance ARO:3007126 ROB-12 ROB-12 Streptomyces lividans otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces lividans. otr(A)S.liv tet antibiotic_resistance ARO:3007127 Streptomyces lividans otr(A) Streptomyces lividans otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces lividans. PMID:1510403 otr(A)S.liv Serine beta-lactamase inhibitors are molecules that inhibit the function of Ambler class A, C, and D beta-lactamases, preventing the inactivation of beta-lactam antibiotics by these enzymes. antibiotic_resistance ARO:3007128 serine beta-lactamase inhibitor Metallo-beta-lactamase inhibitors are molecules that inhibit the function of Ambler class B (metallo-) beta-lactamases, preventing the inactivation of beta-lactam antibiotics by these enzymes. antibiotic_resistance ARO:3007129 metallo-beta-lactamase inhibitor Beta-lactam derived beta-lactamase inhibitors are molecules possessing structural similarity to beta-lactam antibiotics (i.e. beta-lactam ring) that inhibit the function of serine beta-lactamases. antibiotic_resistance ARO:3007130 beta-lactam derived beta-lactamase inhibitor A class of serine beta-lactamase inhibitors. antibiotic_resistance ARO:3007131 boronic acid beta-lactamase inhibitor Serine beta-lactamase inhibitors with unknown or undefined classification. antibiotic_resistance ARO:3007132 unclassified serine beta-lactamase inhibitor A class of metallo-beta-lactamase inhibitors. antibiotic_resistance ARO:3007133 polypyridine metallo-beta-lactamase inhibitor A class of metallo-beta-lactamase inhibitors. antibiotic_resistance ARO:3007134 phosphonate metallo-beta-lactamase inhibitor A class of metallo-beta-lactamase inhibitors. antibiotic_resistance ARO:3007135 bisthiazolidine metallo-beta-lactamase inhibitor Metallo-beta-lactamase inhibitors with unknown or undefined classification. antibiotic_resistance ARO:3007136 unclassified metallo-beta-lactamase inhibitor An MCR-10-type colistin resistance gene variant. mcr-10.1 antibiotic_resistance ARO:3007137 mcr-10.1 An MCR-10-type colistin resistance gene variant. PMID:35695522 mcr-10.1 S02030 is an experimental metallo-beta-lactamase inhibitor that exhibits activity against MOX-1. pubchem.compound:71519576 1-{(2r)-2-(Dihydroxyboranyl)-2-[(Thiophen-2-Ylacetyl)amino]ethyl}-1h-1,2,3-Triazole-4-Carboxylic Acid antibiotic_resistance ARO:3007138 S02030 S02030 is an experimental metallo-beta-lactamase inhibitor that exhibits activity against MOX-1. PMID:34970229 Cordycepin is an experimental nucleoside antibiotic which has been shown to exhibit activity against H. pylori. It is produced by the Cordyceps fungus, which is used in traditional Chinese medicine. pubchem.compound:6303 3'-deoxyadenosine cordycepine antibiotic_resistance ARO:3007139 cordycepin Cordycepin is an experimental nucleoside antibiotic which has been shown to exhibit activity against H. pylori. It is produced by the Cordyceps fungus, which is used in traditional Chinese medicine. PMID:35191475 Unithiol is an experimental chelating agent that forms complexes with heavy metals. It has been shown to inhibit the action of the metallo-beta-lactamases NDM-1 and VIM-2. pubchem.compound:2724039 DMPS antibiotic_resistance ARO:3007140 unithiol Unithiol is an experimental chelating agent that forms complexes with heavy metals. It has been shown to inhibit the action of the metallo-beta-lactamases NDM-1 and VIM-2. PMID:35163756 BLI-489 is an experimental beta-lactamase inhibitor that exhibits broad spectrum activity against class A, B, and D carbapenemases. pubchem.compound:9972353 antibiotic_resistance ARO:3007141 BLI-489 BLI-489 is an experimental beta-lactamase inhibitor that exhibits broad spectrum activity against class A, B, and D carbapenemases. PMID:35165715 Plantacirin A is a short cationic bacteriocin that increases permeability of the bacterial outer membrane, thus enhancing the effect of accompanying antibiotics. It is derived from Lactiplantibacillus plantarum. PlnA antibiotic_resistance ARO:3007142 plantacirin A Plantacirin A is a short cationic bacteriocin that increases permeability of the bacterial outer membrane, thus enhancing the effect of accompanying antibiotics. It is derived from Lactiplantibacillus plantarum. PMID:35499329 Sulopenem is a carbapenem derivative in phase III clinical trials (2022) for the treatment of various gram-positive and gram-negative infections. pubchem.compound:9950244 antibiotic_resistance ARO:3007143 sulopenem Sulopenem is a carbapenem derivative in phase III clinical trials (2022) for the treatment of various gram-positive and gram-negative infections. PMID:35294769 PBT2 is a former Alzheimer's and Huntington's disease candidate drug that has since been shown to increase susceptibility to colistin, polymyxin B, and tetracycline in N. gonorrhoeae. It is thought to inactivate lipooligosaccharide phosphoethanolamine transferase A, resulting in alteration of cell membrane charge. pubchem.compound:10016012 antibiotic_resistance ARO:3007144 PBT2 PBT2 is a former Alzheimer's and Huntington's disease candidate drug that has since been shown to increase susceptibility to colistin, polymyxin B, and tetracycline in N. gonorrhoeae. It is thought to inactivate lipooligosaccharide phosphoethanolamine transferase A, resulting in alteration of cell membrane charge. PMID:34450628 An antibiotic-adjuvant admixture of the beta-lactam antibiotic imipenem, beta-lactam potentiator cilastatin, and beta-lactamase inhibitor relebactam. antibiotic_resistance ARO:3007145 imipenem-cilastatin-relebactam An antibiotic-adjuvant admixture of the beta-lactam antibiotic imipenem, beta-lactam potentiator cilastatin, and beta-lactamase inhibitor relebactam. PMID:29230684 PMID:33580649 An antibiotic-adjuvant admixture of the beta-lactam antibiotic meropenem and the beta-lactamase inhibitor vaborbactam. pubchem.compound:86298703 Carbavance Vabomere antibiotic_resistance ARO:3007146 meropenem-vaborbactam An antibiotic-adjuvant admixture of the beta-lactam antibiotic meropenem and the beta-lactamase inhibitor vaborbactam. PMID:29230684 PMID:29692218 Taniborbactam is a broad-spectrum beta-lactamase inhibitor. As of 2022, it is in phase III clinical trials in combination with cefepime and is the only beta-lactamase inhibitor exhibiting activity against all four classes of beta-lactamase. pubchem.compound:76902493 VNRX-5133 antibiotic_resistance ARO:3007147 taniborbactam Taniborbactam is a broad-spectrum beta-lactamase inhibitor. As of 2022, it is in phase III clinical trials in combination with cefepime and is the only beta-lactamase inhibitor exhibiting activity against all four classes of beta-lactamase. PMID:31871094 An antibiotic cocktail containing the beta-lactam antibiotic cefepime and the beta-lactamase inhibitor taniborbactam. As of 2022, this antibiotic-adjuvant mixture is in phase III clinical trials for the treatment of various bacterial infections. antibiotic_resistance ARO:3007148 cefepime-taniborbactam An antibiotic cocktail containing the beta-lactam antibiotic cefepime and the beta-lactamase inhibitor taniborbactam. As of 2022, this antibiotic-adjuvant mixture is in phase III clinical trials for the treatment of various bacterial infections. PMID:31871094 A group of antibiotics derived from phosphonic acids. antibiotic_resistance ARO:3007149 phosphonic acid antibiotic A group of antibiotics derived from phosphonic acids. PMID:10477522 PMID:5809587 A group of antibiotics including bicyclomycin and its analogues. antibiotic_resistance ARO:3007150 bicyclomycin-like antibiotic A group of antibiotics including bicyclomycin and its analogues. PMID:7487110 A group of antibiotics including mupirocin and similar mixtures (such as those including pseudomonic acid A). antibiotic_resistance ARO:3007151 mupirocin-like antibiotic A group of antibiotics including mupirocin and similar mixtures (such as those including pseudomonic acid A). PMID:21336932 A group of antibiotics containing isoniazid and its derivatives. antibiotic_resistance ARO:3007152 isoniazid-like antibiotic A group of antibiotics containing isoniazid and its derivatives. PMID:8143118 A group of antibiotics possessing steroid rings or steroid-like structures. antibiotic_resistance ARO:3007153 fusidane antibiotic A group of antibiotics possessing steroid rings or steroid-like structures. PMID:32915993 A group of antibiotics including cycloserine and its derivatives. antibiotic_resistance ARO:3007154 cycloserine-like antibiotic A group of antibiotics including cycloserine and its derivatives. PMID:4555420 A group of antibiotics derived from pyrazine. antibiotic_resistance ARO:3007155 pyrazine antibiotic A group of antibiotics derived from pyrazine. PMID:26104205 A group of antibiotics possessing the thioamide functional group. antibiotic_resistance ARO:3007156 thioamide antibiotic A group of antibiotics possessing the thioamide functional group. PMID:26586647 A group of antibiotics including nybomycin and its derivatives. antibiotic_resistance ARO:3007157 nybomycin-like antibiotic A group of antibiotics including pactamycin and its derivatives. antibiotic_resistance ARO:3007158 pactamycin-like antibiotic A group of antibiotics derived from salicylic acid. antibiotic_resistance ARO:3007159 salicylic acid antibiotic A group of antibiotics including the experimental compound zoliflodacin and its derivatives. antibiotic_resistance ARO:3007160 zoliflodacin-like antibiotic A group of antibiotics including the experimental compound zoliflodacin and its derivatives. PMID:31730160 A group of antibiotics derived from thiosemicarbazide (possessing the thiosemicarbazone functional group). antibiotic_resistance ARO:3007161 thiosemicarbazone antibiotic A group of antibiotics derived from thiosemicarbazide (possessing the thiosemicarbazone functional group). PMID:18094751 PMID:33022959 A group of peptidomimetic antibiotics based on the peptide protegrin-1. antibiotic_resistance ARO:3007162 protegrin-1-like antibiotic A group of peptidomimetic antibiotics based on the peptide protegrin-1. PMID:20167788 A group of antibiotics including albendazole and similar antiparasitic compounds that exhibit antibacterial activity. antibiotic_resistance ARO:3007163 albendazole-like antibiotic A group of antibiotics including albendazole and similar antiparasitic compounds that exhibit antibacterial activity. PMID:35453279 A group of antibiotics derived from triazaacenaphthylene. antibiotic_resistance ARO:3007164 triazaacenaphthylene antibiotic Gemifloxacin is a broad-spectrum, fourth generation, oral fluoroquinolone antibiotic used in the treatment of various bacterial infections, primarily in the lungs. It has been discontinued for therapeutic use in the US over concerns of tendon and peripheral neuron toxicity, although it is still available for experimental application and elsewhere for therapeutic use. It is usually administered as a mesylate salt, gemifloxacin mesylate. pubchem.compound:9571107 Factive antibiotic_resistance ARO:3007165 gemifloxacin Gemifloxacin is a broad-spectrum, fourth generation, oral fluoroquinolone antibiotic used in the treatment of various bacterial infections, primarily in the lungs. It has been discontinued for therapeutic use in the US over concerns of tendon and peripheral neuron toxicity, although it is still available for experimental application and elsewhere for therapeutic use. It is usually administered as a mesylate salt, gemifloxacin mesylate. PMID:12764426 Orthosomycins are a group of experimental/veterinary orthoester and oligosaccharide antibiotics that target the 70s ribosomal subunit. They are generally no longer considered potential clinical antibiotics, but continue to be used in livestock feed and for experimental purposes. antibiotic_resistance ARO:3007166 orthosomycin antibiotic Orthosomycins are a group of experimental/veterinary orthoester and oligosaccharide antibiotics that target the 70s ribosomal subunit. They are generally no longer considered potential clinical antibiotics, but continue to be used in livestock feed and for experimental purposes. PMID:27330110 Evernimicin is a veterinary oligosaccharide antibiotic of the orthosomycin group of orthoester antibiotics. Along with avilamycin, it exhibits activity against a variety of Gram-positive and -negative bacteria and is primarily used in livestock feed. pubchem.compound:6917933 everninomicin antibiotic_resistance ARO:3007167 evernimicin Evernimicin is a veterinary oligosaccharide antibiotic of the orthosomycin group of orthoester antibiotics. Along with avilamycin, it exhibits activity against a variety of Gram-positive and -negative bacteria and is primarily used in livestock feed. PMID:27330110 Avilamycin is an experimental oligosaccharide antibiotic of the orthosomycin group of orthoester antibiotics. Along with evernimicin, it exhibits activity against a variety of Gram-positive and -negative bacteria. pubchem.compound:76959299 antibiotic_resistance ARO:3007168 avalimycin Avilamycin is an experimental oligosaccharide antibiotic of the orthosomycin group of orthoester antibiotics. Along with evernimicin, it exhibits activity against a variety of Gram-positive and -negative bacteria. PMID:27330110 Pirlimycin is an experimental/veterinary lincosamide antibiotic. Although not approved for use in humans, pirlimycin is commonly used to treat mammary gland infections in cattle. pubchem.compound:157385 Pirsue antibiotic_resistance ARO:3007169 pirlimycin Pirlimycin is an experimental/veterinary lincosamide antibiotic. Although not approved for use in humans, pirlimycin is commonly used to treat mammary gland infections in cattle. PMID:12584673 Enmetazobactam is a beta-lactamase inhibitor which exhibits activity against class A extended spectrum beta-lactamases. It is currently in clinical trials in combination with cefepine for the treatment of urinary tract infections and acute pyelonephritis. pubchem.compound:23653540 antibiotic_resistance ARO:3007171 enmetazobactam Enmetazobactam is a beta-lactamase inhibitor which exhibits activity against class A extended spectrum beta-lactamases. It is currently in clinical trials in combination with cefepine for the treatment of urinary tract infections and acute pyelonephritis. PMID:32253212 PMID:35486701 Methimazole is thiamide usually used to treat hyperthyroidism. It has also demonstrated potent inhibition of NDM-1 and synergistic effects against other metallo-beta-lactamases when paired with meropenem. pubchem.compound:1349907 Tapazole thiamazole antibiotic_resistance ARO:3007172 methimazole Methimazole is thiamide usually used to treat hyperthyroidism. It has also demonstrated potent inhibition of NDM-1 and synergistic effects against other metallo-beta-lactamases when paired with meropenem. PMID:35197545 Lipoic acid is a compound used for diabetic neuropathy and as a nutritional supplement. It has also demonstrated potent inhibition of NDM-1 and synergistic effects against other metallo-beta-lactamases when paired with meropenem. pubchem.compound:864 alpha-lipoic acid antibiotic_resistance ARO:3007173 lipoic acid Lipoic acid is a compound used for diabetic neuropathy and as a nutritional supplement. It has also demonstrated potent inhibition of NDM-1 and synergistic effects against other metallo-beta-lactamases when paired with meropenem. PMID:35197545 Scutellarin is an experimental antibiotic potentiator that inhibits bacterial sortase A and caseinolytic peptidase P. When used in combination with vancomycin against methicillin-resistant Staphylococcus aureus, scutellarin improves activity of the antibiotic, making it an effective adjuvant in the treatment of such infections. pubchem.compound:185617 antibiotic_resistance ARO:3007174 scutellarin Scutellarin is an experimental antibiotic potentiator that inhibits bacterial sortase A and caseinolytic peptidase P. When used in combination with vancomycin against methicillin-resistant Staphylococcus aureus, scutellarin improves activity of the antibiotic, making it an effective adjuvant in the treatment of such infections. PMID:35247333 TP0586532 is an antibiotic potentiator that acts by inhibiting bacterial LpxC, interfering with the production of lipopolysaccharides. It has been shown to increase the effects of several antibiotics, such as meropenem, amikacin, cefepime, and tigecycline. The disruption of lipopolysaccharide synthesis is suspected to lead to increased membrane permeability. pubchem.compound:155294517 antibiotic_resistance ARO:3007175 TP0586532 TP0586532 is an antibiotic potentiator that acts by inhibiting bacterial LpxC, interfering with the production of lipopolysaccharides. It has been shown to increase the effects of several antibiotics, such as meropenem, amikacin, cefepime, and tigecycline. The disruption of lipopolysaccharide synthesis is suspected to lead to increased membrane permeability. PMID:35647694 TNP-2198 is an experimental rifamycin-nitroimidazole conjugate currently in development for treatment of several bacterial infections. It exhibits greater activity than rifamycin and nitroimidazole antibiotics administered together and is effective against bacteria resistant to both drug classes. pubchem.compound:136014272 antibiotic_resistance ARO:3007176 TNP-2198 TNP-2198 is an experimental rifamycin-nitroimidazole conjugate currently in development for treatment of several bacterial infections. It exhibits greater activity than rifamycin and nitroimidazole antibiotics administered together and is effective against bacteria resistant to both drug classes. PMID:35175750 Antibiotics belonging to the thiazolide group. Note that many thiazolides are used as antiviral compounds, however some have also exhibited antibacterial activity. antibiotic_resistance ARO:3007177 thiazolide antibiotic Nitazoxanide is a thiazolide antiparatasitic and antiviral drug that has demonstrated antibacterial activity against Helicobacter pylori. It is well tolerated and exhibits a synergistic effect with other antibiotics, such as clarithromycin. pubchem.compound:41684 Alinia Nizonide nitazoxamide antibiotic_resistance ARO:3007178 nitazoxanide Nitazoxanide is a thiazolide antiparatasitic and antiviral drug that has demonstrated antibacterial activity against Helicobacter pylori. It is well tolerated and exhibits a synergistic effect with other antibiotics, such as clarithromycin. PMID:35587063 Class A beta-lactamse from M. abscessus. antibiotic_resistance ARO:3007179 class A Mycobacterium abscessus beta-lactamase Class A beta-lactamse from M. abscessus. PMID:24132992 PMID:28096155 MAB is a broad-spectrum class A beta-lactamase produced by Mycobacterium abscessus that has been shown to hydrolyze a large number of beta-lactam antibiotics. MAB antibiotic_resistance ARO:3007180 MAB MAB is a broad-spectrum class A beta-lactamase produced by Mycobacterium abscessus that has been shown to hydrolyze a large number of beta-lactam antibiotics. PMID:24132992 PMID:28096155 MAB Class A beta-lactamase from M. tuberculosis. antibiotic_resistance ARO:3007181 class A Mycobacterium tuberculosis bla beta-lactamase Class A beta-lactamase from M. tuberculosis. PMID:20353175 PMID:24132992 blaC is a broad-spectrum class A beta-lactamase coded in the chromosome of Mycobacterium tuberculosis. It has been shown to hydrolyze a large number of beta-lactam antibiotics and is a major obstacle in the treatment of tuberculosis with such drugs. blaC antibiotic_resistance ARO:3007182 blaC blaC is a broad-spectrum class A beta-lactamase coded in the chromosome of Mycobacterium tuberculosis. It has been shown to hydrolyze a large number of beta-lactam antibiotics and is a major obstacle in the treatment of tuberculosis with such drugs. PMID:20353175 PMID:24132992 blaC Mutations in the Rv1258c (Tap) efflux pump contributing to antibiotic resistance. antibiotic_resistance ARO:3007183 antibiotic resistant Rv1258c Mutations in the Rv1258c efflux pump contributing to resistance to multiple antibiotics. antibiotic_resistance ARO:3007184 multidrug resistant Rv1258c Mutations in the Rv1258c efflux pump contributing to resistance to multiple antibiotics. PMID:30837962 PMID:35158297 Mutations in the M. tuberculosis efflux pump Rv1258c (Tap) conferring resistance to multiple ethambutol and capreomycin. Mtub_tap_EMCM antibiotic_resistance ARO:3007185 Mycobacterium tuberculosis Rv1258c mutations confer resistance to ethambutol and capreomycin Mutations in the M. tuberculosis efflux pump Rv1258c (Tap) conferring resistance to multiple ethambutol and capreomycin. PMID:35158297 Mtub_tap_EMCM Mutations in the M. tuberculosis efflux pump Rv1258c (Tap) conferring resistance to pyrazinamide, isoniazid, and streptomycin. Mtub_tap_MULT antibiotic_resistance ARO:3007186 Mycobacterium tuberculosis Rv1258c mutations confer resistance to pyrazinamide, isoniazid, and streptomycin Mutations in the M. tuberculosis efflux pump Rv1258c (Tap) conferring resistance to pyrazinamide, isoniazid, and streptomycin. PMID:30837962 Mtub_tap_MULT This cluster confers resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Resistance is acquired after multiple treatments with sub-minimum inhibitory concentrations of vancomycin. Gene orientation: vanHPXRS. vanP_cluster antibiotic_resistance ARO:3007187 glycopeptide resistance gene cluster vanP This cluster confers resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Resistance is acquired after multiple treatments with sub-minimum inhibitory concentrations of vancomycin. Gene orientation: vanHPXRS. PMID:34505571 vanP_cluster vanH variant in the vanP cluster. vanH-P vanHP vanH_in_vanP_cl antibiotic_resistance ARO:3007188 vanH gene in vanP cluster vanH variant in the vanP cluster. PMID:34505571 vanH_in_vanP_cl vanP is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. vanP antibiotic_resistance ARO:3007189 vanP vanP is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. PMID:34505571 vanP vanX variant in the vanP cluster. vanX-P vanXP vanX_in_vanP_cl antibiotic_resistance ARO:3007190 vanX gene in vanP cluster vanX variant in the vanP cluster. PMID:34505571 vanX_in_vanP_cl vanR variant in the vanP cluster. vanR-P vanRP vanR_in_vanP_cl antibiotic_resistance ARO:3007191 vanR gene in vanP cluster vanR variant in the vanP cluster. PMID:34505571 vanR_in_vanP_cl vanS variant in the vanP cluster. vanS-P vanSP vanS_in_vanP_cl antibiotic_resistance ARO:3007192 vanS gene in vanP cluster vanS variant in the vanP cluster. PMID:34505571 vanS_in_vanP_cl The National Committee for Clinical Laboratory Standards is an American organization responsible for developing accredited consensus clinical laboratory standards. antibiotic_resistance ARO:3007193 National Committee for Clinical Laboratory Standards (NCCLS) The National Committee for Clinical Laboratory Standards is an American organization responsible for developing accredited consensus clinical laboratory standards. PMID:11977864 Groups, organizations, and government bodies dedicated to the surveillance of antimicrobial resistance. antibiotic_resistance ARO:3007194 antimicrobial resistance surveillance systems The National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS) is a US public health surveillance system that tracks antimicrobial resistance in foodborne and other enteric bacteria. antibiotic_resistance ARO:3007195 National Antimicrobial Resistance Monitoring System (NARMS) The National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS) is a US public health surveillance system that tracks antimicrobial resistance in foodborne and other enteric bacteria. PMID:17927472 KPC-123 is a KPC beta-lactamase. KPC-123 antibiotic_resistance ARO:3007196 KPC-123 KPC-123 is a KPC beta-lactamase. PMID:35794918 KPC-123 Enramycin is a polypeptide antibiotic commonly used as a feed additive for livestock. It is produced by species of the Streptomyces genus and is used to prevent necrotic enteritis in poultry and pigs. Enramycin disrupts cell wall synthesis by inhibiting MurG. pubchem.compound:56842192 antibiotic_resistance ARO:3007197 enramycin Enramycin is a polypeptide antibiotic commonly used as a feed additive for livestock. It is produced by species of the Streptomyces genus and is used to prevent necrotic enteritis in poultry and pigs. Enramycin disrupts cell wall synthesis by inhibiting MurG. PMID:35841645 A family of subclass B3 metallo-beta-lactamases discovered in Pseudomonas alcaligenes and found in other members of the Pseudomonas genus. PAM beta-lactamases hydrolyze cephalosporins and carbenems. antibiotic_resistance ARO:3007198 PAM beta-lactamase A family of subclass B3 metallo-beta-lactamases discovered in Pseudomonas alcaligenes and found in other members of the Pseudomonas genus. PAM beta-lactamases hydrolyze cephalosporins and carbenems. PMID:24356301 PMID:33577996 PAM-1 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Psuedomonas genus. PAM-1 antibiotic_resistance ARO:3007199 PAM-1 PAM-1 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Psuedomonas genus. PMID:24356301 PAM-1 PAM-2 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Pseudomonas genus. PAM-2 antibiotic_resistance ARO:3007200 PAM-2 PAM-2 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Pseudomonas genus. PMID:33577996 PAM-2 PAM-3 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Pseudomonas genus. The sequence of PAM-3 was made available through NCBI's Reference Gene Catalogue. PAM-3 antibiotic_resistance ARO:3007201 PAM-3 PAM-3 New Delhi class B metallo-beta-lactamase 16b variant. NDM-16b antibiotic_resistance ARO:3007202 NDM-16b New Delhi class B metallo-beta-lactamase 16b variant. PMID:35867355 NDM-16b Mutations in Klebsiella pneumoniae PhoQ of the two-component PhoPQ regulatory system conferring resistance to colistin. Kpne_PhoQ_CST antibiotic_resistance ARO:3007203 Klebsiella pneumoniae mutant PhoQ conferring resistance to colistin Mutations in Klebsiella pneumoniae PhoQ of the two-component PhoPQ regulatory system conferring resistance to colistin. PMID:35920875 Kpne_PhoQ_CST AAC(6')-Iap is an aminoglycoside acetyltransferase that confers resistance to a number of aminoglycoside antibiotics. AAC(6')-Iap antibiotic_resistance ARO:3007204 AAC(6')-Iap AAC(6')-Iap is an aminoglycoside acetyltransferase that confers resistance to a number of aminoglycoside antibiotics. PMID:35862995 AAC(6')-Iap Kathmandu beta-lactamases are a group of class A beta-lactamases that hydrolyze penicillin antibiotics. antibiotic_resistance ARO:3007205 KBL beta-lactamase Kathmandu beta-lactamases are a group of class A beta-lactamases that hydrolyze penicillin antibiotics. PMID:35862995 KBL-1 is a KBL class A beta-lactamase that confers resistance to a number of penicillin antibiotics. KBL-1 antibiotic_resistance ARO:3007206 KBL-1 KBL-1 is a KBL class A beta-lactamase that confers resistance to a number of penicillin antibiotics. PMID:35862995 KBL-1 Helicase-like proteins that confer resistance to antibiotics such as rifamycins by preventing or disrupting their binding to RNA polymerase. antibiotic_resistance ARO:3007207 helicase-like RNA polymerase protection protein Helicase-like proteins that confer resistance to antibiotics such as rifamycins by preventing or disrupting their binding to RNA polymerase. PMID:35907401 HelR is a helicase-like protein that confers resistance to rifamycins by displacing them from the RNA polymerase complex. The protein forces the antibiotic away from the polymerase by binding in its place. It then ejects itself from the complex, allowing the polymerase to resume normal function. HelR antibiotic_resistance ARO:3007208 HelR HelR is a helicase-like protein that confers resistance to rifamycins by displacing them from the RNA polymerase complex. The protein forces the antibiotic away from the polymerase by binding in its place. It then ejects itself from the complex, allowing the polymerase to resume normal function. PMID:35907401 HelR Streptomyces venezuelae rox is a class A flavoprotein monooxygenase that confers resistance to rifamycin antibiotics. It acts by oxygenating the naphthyl group of the antibiotic, leading to a ring opening event and linearization of the molecule. Rox-sv Sven_rox antibiotic_resistance ARO:3007209 Streptomyces venezuelae rox Streptomyces venezuelae rox is a class A flavoprotein monooxygenase that confers resistance to rifamycin antibiotics. It acts by oxygenating the naphthyl group of the antibiotic, leading to a ring opening event and linearization of the molecule. PMID:29398560 Sven_rox Nocardia farcinica rox is a rifampin monooxygenase that inactivates rifampin. Nfar_rox Rox-nf antibiotic_resistance ARO:3007210 Nocardia farcinica rox Nocardia farcinica rox is a rifampin monooxygenase that inactivates rifampin. PMID:19942945 Nfar_rox NDM-34 is a NDM beta-lactamase. NDM-34 antibiotic_resistance ARO:3007211 NDM-34 NDM-34 NDM-35 is a NDM beta-lactamase. NDM-35 antibiotic_resistance ARO:3007212 NDM-35 NDM-35 NDM-36 is a NDM beta-lactamase. NDM-36 antibiotic_resistance ARO:3007213 NDM-36 NDM-36 NDM-37 is a NDM beta-lactamase. NDM-37 antibiotic_resistance ARO:3007214 NDM-37 NDM-37 NDM-38 is a NDM beta-lactamase. NDM-38 antibiotic_resistance ARO:3007215 NDM-38 NDM-38 NDM-39 is a NDM beta-lactamase. NDM-39 antibiotic_resistance ARO:3007216 NDM-39 NDM-39 NDM-40 is a NDM beta-lactamase. NDM-40 antibiotic_resistance ARO:3007217 NDM-40 NDM-40 NDM-41 is a NDM beta-lactamase. NDM-41 antibiotic_resistance ARO:3007218 NDM-41 NDM-41 NDM-42 is a NDM beta-lactamase. NDM-42 antibiotic_resistance ARO:3007219 NDM-42 NDM-42 NDM-43 is a NDM beta-lactamase. NDM-43 antibiotic_resistance ARO:3007220 NDM-43 NDM-43 An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor. N,N,N'-tris(2-pyridylmethyl)-ethylenediamine-N'-acetic acid antibiotic_resistance ARO:3007221 trispicenA An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor. PMID:33285370 A class of antibiotic adjuvant in which the adjuvant directly or indirectly inhibits the mechanism of resistance, restoring antibiotic susceptibility or decreasing the minimum inhibitory concentration. antibiotic_resistance ARO:3007222 inhibitor of antibiotic resistance mechanism A class of antibiotic adjuvants which enhance the antibiotic capability to enter the cell through passive or active membrane transport. antibiotic_resistance ARO:3007223 adjuvants enhancing antibiotic entry A class of adjuvants which inhibit or prevent the cellular removal of an antibiotic through mechanisms including antibiotic efflux. antibiotic_resistance ARO:3007224 adjuvants inhibiting antibiotic removal A class of antibiotic adjuvants which indirectly increase antibiotic susceptibility through alterations to cellular physiology, for example those adjuvants which inhibit biofilm formation. antibiotic_resistance ARO:3007225 adjuvants which alter physiology A class of antibiotic adjuvants which indirectly improve antibiotic susceptibility or retention through alterations to host physiology or metabolism. antibiotic_resistance ARO:3007226 host-related antibiotic adjuvants An MCR-8-type colistin resistance gene variant. MCR-8.3 antibiotic_resistance ARO:3007227 MCR-8.3 An MCR-8-type colistin resistance gene variant. PMID:31849875 MCR-8.3 An MCR-8-type colistin resistance gene variant. MCR-8.4 antibiotic_resistance ARO:3007228 MCR-8.4 An MCR-8-type colistin resistance gene variant. PMID:30828324 MCR-8.4 An MCR-8-type colistin resistance gene variant. MCR-8.2 antibiotic_resistance ARO:3007229 MCR-8.2 An MCR-8-type colistin resistance gene variant. PMID:30864883 MCR-8.2 An MCR-1-type colistin resistance gene variant. MCR-1.34 antibiotic_resistance ARO:3007230 MCR-1.34 MCR-1.34 An MCR-4-type colistin resistance gene variant. MCR-4.6 antibiotic_resistance ARO:3007231 MCR-4.6 MCR-4.6 An MCR-1-type colistin resistance gene variant. MCR-1.27 antibiotic_resistance ARO:3007232 MCR-1.27 MCR-1.27 An MCR-1-type colistin resistance gene variant. MCR-1.18 antibiotic_resistance ARO:3007233 MCR-1.18 MCR-1.18 An MCR-1-type colistin resistance gene variant. MCR-1.23 antibiotic_resistance ARO:3007234 MCR-1.23 MCR-1.23 An MCR-1-type colistin resistance gene variant. MCR-1.20 antibiotic_resistance ARO:3007235 MCR-1.20 MCR-1.20 An MCR-1-type colistin resistance gene variant. MCR-1.28 antibiotic_resistance ARO:3007236 MCR-1.28 MCR-1.28 An MCR-1-type colistin resistance gene variant. MCR-1.21 antibiotic_resistance ARO:3007237 MCR-1.21 MCR-1.21 An MCR-1-type colistin resistance gene variant. MCR-1.16 antibiotic_resistance ARO:3007238 MCR-1.16 MCR-1.16 An MCR-1-type colistin resistance gene variant. MCR-1.22 antibiotic_resistance ARO:3007239 MCR-1.22 An MCR-1-type colistin resistance gene variant. PMID:34091039 MCR-1.22 An MCR-1-type colistin resistance gene variant. MCR-1.19 antibiotic_resistance ARO:3007240 MCR-1.19 MCR-1.19 An MCR-1-type colistin resistance gene variant. MCR-1.29 antibiotic_resistance ARO:3007241 MCR-1.29 MCR-1.29 An MCR-1-type colistin resistance gene variant. MCR-1.30 antibiotic_resistance ARO:3007242 MCR-1.30 MCR-1.30 An MCR-1-type colistin resistance gene variant. MCR-1.24 antibiotic_resistance ARO:3007243 MCR-1.24 MCR-1.24 An MCR-1-type colistin resistance gene variant. MCR-1.17 antibiotic_resistance ARO:3007244 MCR-1.17 MCR-1.17 An MCR-1-type colistin resistance gene variant. MCR-1.31 antibiotic_resistance ARO:3007245 MCR-1.31 MCR-1.31 An MCR-1-type colistin resistance gene variant. MCR-1.14 antibiotic_resistance ARO:3007246 MCR-1.14 MCR-1.14 An MCR-1-type colistin resistance gene variant. MCR-1.25 antibiotic_resistance ARO:3007247 MCR-1.25 MCR-1.25 An MCR-3-type colistin resistance gene variant. MCR-3.33 antibiotic_resistance ARO:3007248 MCR-3.33 An MCR-3-type colistin resistance gene variant. PMID:34187559 MCR-3.33 An MCR-3-type colistin resistance gene variant. MCR-3.14 antibiotic_resistance ARO:3007249 MCR-3.14 MCR-3.14 An MCR-3-type colistin resistance gene variant. MCR-3.37 antibiotic_resistance ARO:3007250 MCR-3.37 An MCR-3-type colistin resistance gene variant. PMID:34187559 MCR-3.37 An MCR-3-type colistin resistance gene variant. MCR-3.38 antibiotic_resistance ARO:3007251 MCR-3.38 MCR-3.38 An MCR-3-type colistin resistance gene variant. MCR-3.15 antibiotic_resistance ARO:3007252 MCR-3.15 MCR-3.15 An MCR-3-type colistin resistance gene variant. MCR-3.27 antibiotic_resistance ARO:3007253 MCR-3.27 MCR-3.27 An MCR-3-type colistin resistance gene variant. MCR-3.32 antibiotic_resistance ARO:3007254 MCR-3.32 MCR-3.32 An MCR-3-type colistin resistance gene variant. MCR-3.31 antibiotic_resistance ARO:3007255 MCR-3.31 MCR-3.31 An MCR-3-type colistin resistance gene variant. MCR-3.23 antibiotic_resistance ARO:3007256 MCR-3.23 MCR-3.23 An MCR-3-type colistin resistance gene variant. MCR-3.36 antibiotic_resistance ARO:3007257 MCR-3.36 An MCR-3-type colistin resistance gene variant. PMID:34187559 MCR-3.36 An MCR-3-type colistin resistance gene variant. MCR-3.25 antibiotic_resistance ARO:3007258 MCR-3.25 MCR-3.25 An MCR-3-type colistin resistance gene variant. MCR-3.22 antibiotic_resistance ARO:3007259 MCR-3.22 MCR-3.22 An MCR-3-type colistin resistance gene variant. MCR-3.16 antibiotic_resistance ARO:3007260 MCR-3.16 MCR-3.16 An MCR-3-type colistin resistance gene variant. MCR-3.26 antibiotic_resistance ARO:3007261 MCR-3.26 MCR-3.26 An MCR-3-type colistin resistance gene variant. MCR-3.21 antibiotic_resistance ARO:3007262 MCR-3.21 MCR-3.21 An MCR-3-type colistin resistance gene variant. MCR-3.18 antibiotic_resistance ARO:3007263 MCR-3.18 MCR-3.18 An MCR-3-type colistin resistance gene variant. MCR-3.40 antibiotic_resistance ARO:3007264 MCR-3.40 MCR-3.40 An MCR-3-type colistin resistance gene variant. MCR-3.24 antibiotic_resistance ARO:3007265 MCR-3.24 MCR-3.24 An MCR-3-type colistin resistance gene variant. MCR-3.20 antibiotic_resistance ARO:3007266 MCR-3.20 MCR-3.20 An MCR-3-type colistin resistance gene variant. MCR-3.35 antibiotic_resistance ARO:3007267 MCR-3.35 An MCR-3-type colistin resistance gene variant. PMID:34187559 MCR-3.35 An MCR-3-type colistin resistance gene variant. MCR-3.34 antibiotic_resistance ARO:3007268 MCR-3.34 An MCR-3-type colistin resistance gene variant. PMID:34187559 MCR-3.34 An MCR-3-type colistin resistance gene variant. MCR-3.13 antibiotic_resistance ARO:3007269 MCR-3.13 MCR-3.13 An MCR-3-type colistin resistance gene variant. MCR-3.28 antibiotic_resistance ARO:3007270 MCR-3.28 MCR-3.28 An MCR-3-type colistin resistance gene variant. MCR-3.39 antibiotic_resistance ARO:3007271 MCR-3.39 MCR-3.39 An MCR-3-type colistin resistance gene variant. MCR-3.29 antibiotic_resistance ARO:3007272 MCR-3.29 MCR-3.29 An MCR-3-type colistin resistance gene variant. MCR-3.19 antibiotic_resistance ARO:3007273 MCR-3.19 MCR-3.19 An MCR-10-type colistin resistance gene variant. MCR-10.5 antibiotic_resistance ARO:3007274 MCR-10.5 MCR-10.5 An MCR-10-type colistin resistance gene variant. MCR-10.3 antibiotic_resistance ARO:3007275 MCR-10.3 MCR-10.3 An MCR-10-type colistin resistance gene variant. MCR-10.4 antibiotic_resistance ARO:3007276 MCR-10.4 MCR-10.4 An MCR-10-type colistin resistance gene variant. MCR-10.2 antibiotic_resistance ARO:3007277 MCR-10.2 MCR-10.2 An MCR-3-type colistin resistance gene variant. MCR-3.17 antibiotic_resistance ARO:3007278 MCR-3.17 MCR-3.17 An MCR-1-type colistin resistance gene variant. MCR-1.15 antibiotic_resistance ARO:3007279 MCR-1.15 MCR-1.15 An MCR-1-type colistin resistance gene variant. MCR-1.26 antibiotic_resistance ARO:3007280 MCR-1.26 MCR-1.26 An MCR-5-type colistin resistance gene variant. MCR-5.4 antibiotic_resistance ARO:3007281 MCR-5.4 MCR-5.4 An MCR-5-type colistin resistance gene variant. MCR-5.3 antibiotic_resistance ARO:3007282 MCR-5.3 An MCR-5-type colistin resistance gene variant. PMID:30864883 MCR-5.3 An MCR-2-type colistin resistance gene variant. MCR-2.4 antibiotic_resistance ARO:3007283 MCR-2.4 MCR-2.4 An MCR-2-type colistin resistance gene variant. MCR-2.3 antibiotic_resistance ARO:3007284 MCR-2.3 MCR-2.3 An MCR-2-type colistin resistance gene variant. MCR-2.8 antibiotic_resistance ARO:3007285 MCR-2.8 MCR-2.8 An MCR-2-type colistin resistance gene variant. MCR-2.5 antibiotic_resistance ARO:3007286 MCR-2.5 MCR-2.5 An MCR-2-type colistin resistance gene variant. MCR-2.7 antibiotic_resistance ARO:3007287 MCR-2.7 MCR-2.7 An MCR-2-type colistin resistance gene variant. MCR-2.6 antibiotic_resistance ARO:3007288 MCR-2.6 MCR-2.6 An MCR-1-type colistin resistance gene variant. MCR-1.32 antibiotic_resistance ARO:3007289 MCR-1.32 MCR-1.32 Adjuvants shown to inhibit the action of fosfomycin thiol transferases. antibiotic_resistance ARO:3007290 fosfomycin thiol transferase inhibitor Adjuvants shown to inhibit the action of fosfomycin thiol transferases. PMID:15504029 Adjuvants shown to inhibit the action of aminoglycoside inactivating enzymes, such as the APH and AAC enzyme families. antibiotic_resistance ARO:3007291 inhibitor of aminoglycoside inactivation enzyme Adjuvants shown to inhibit the action of aminoglycoside inactivating enzymes, such as the APH and AAC enzyme families. PMID:22760297 PMID:23758273 Adjuvants shown to inhibit the action of mobile colistin resistance phosphoethanolamine transferase genes. antibiotic_resistance ARO:3007292 MCR phosphoethanolamine transferase inhibitor Adjuvants shown to inhibit the action of mobile colistin resistance phosphoethanolamine transferase genes. PMID:29339386 Durlobactam is a broad-spectrum diazabicyclooctane beta-lactamase inhibitor capable to inhibiting class A, C, and D beta-lactamases. pubchem.compound:89851852 ETX-2514 antibiotic_resistance ARO:3007293 durlobactam Durlobactam is a broad-spectrum diazabicyclooctane beta-lactamase inhibitor capable to inhibiting class A, C, and D beta-lactamases. PMID:34349751 ANT-431 is an experimental beta-lactamase inhibitor shown to inhibit the action of NDM-1 and VIM-2. pubchem.compound:86566878 antibiotic_resistance ARO:3007294 ANT-431 ANT-431 is an experimental beta-lactamase inhibitor shown to inhibit the action of NDM-1 and VIM-2. PMID:29530861 Nacubactam is a diazabicyclooctane that inhibits a variety of class A and C beta-lactamases. pubchem.compound:73386748 antibiotic_resistance ARO:3007295 nacubactam Nacubactam is a diazabicyclooctane that inhibits a variety of class A and C beta-lactamases. PMID:31182530 Zidebactam is a diazabicyclooctane that inhibitors a variety of class A and C beta-lactamases. pubchem.compound:77846445 antibiotic_resistance ARO:3007296 zidebactam Zidebactam is a diazabicyclooctane that inhibitors a variety of class A and C beta-lactamases. PMID:30670419 ARX1796 is an orally bioavailable prodrug of avibactam. pubchem.compound:135339165 antibiotic_resistance ARO:3007297 ARX1796 ARX1796 is an orally bioavailable prodrug of avibactam. PMID:34357517 Ledaborbactam is an experimental boronic acid beta-lactamase inhibitor that has shown been show to inhibitor several serine beta-lactamases. pubchem.compound:138455079 VNRX-5236 antibiotic_resistance ARO:3007298 ledaborbactam Ledaborbactam is an experimental boronic acid beta-lactamase inhibitor that has shown been show to inhibitor several serine beta-lactamases. PMID:34001510 Ledaborbactam Etzadroxil is an orally bioavailable prodrug of ledaborbactam. pubchem.compound:138455030 VNRX-7145 antibiotic_resistance ARO:3007299 ledaborbactam etzadroxil Ledaborbactam Etzadroxil is an orally bioavailable prodrug of ledaborbactam. PMID:34191513 L-captopril is a drug used to treat hypertension that has been shown to chelate certain metallo-beta-lactamases. pubchem.compound:44093 antibiotic_resistance ARO:3007300 L-captopril L-captopril is a drug used to treat hypertension that has been shown to chelate certain metallo-beta-lactamases. PMID:26482303 D-captopril is an isomer of L-captopril and is able to chelate certain metallo-beta-lactamases. pubchem.compound:447055 antibiotic_resistance ARO:3007301 D-captopril D-captopril is an isomer of L-captopril and is able to chelate certain metallo-beta-lactamases. PMID:26482303 Thiorphan is the active metabolite of the antidieuretic drug racecadotril. It has shown inhibitory activity against various metallo-beta-lactamases. pubchem.compound:3132 antibiotic_resistance ARO:3007302 thiorphan Thiorphan is the active metabolite of the antidieuretic drug racecadotril. It has shown inhibitory activity against various metallo-beta-lactamases. PMID:31663735 Tiopronin is a drug used to prevent and manage kidney stones in cystinuria patients. It has shown inhibitory activity against various metallo-beta-lactamases. pubchem.compound:5483 antibiotic_resistance ARO:3007303 tiopronin Tiopronin is a drug used to prevent and manage kidney stones in cystinuria patients. It has shown inhibitory activity against various metallo-beta-lactamases. PMID:31663735 Dimercaprol is a compound used to treat acute arsenic poisoning, as well as poisoning of other metals such as mercury, gold, and antimony. It has shown inhibitory activity against various metallo-beta-lactamases. pubchem.compound:3080 antibiotic_resistance ARO:3007304 dimercaprol Dimercaprol is a compound used to treat acute arsenic poisoning, as well as poisoning of other metals such as mercury, gold, and antimony. It has shown inhibitory activity against various metallo-beta-lactamases. PMID:31663735 ME1071 is an experimental metallo-beta-lactamase inhibitor. pubchem.compound:16064853 antibiotic_resistance ARO:3007305 ME1071 ME1071 is an experimental metallo-beta-lactamase inhibitor. PMID:23891525 Phosphonoformate, also known as Forscarnet or Foscavir, is an antiviral drug used to treat Herpesviridae infections. It has also been shown to inhibit the fosfomycin thiol transferase fosA. pubchem.compound:3415 Foscarnet Foscavir antibiotic_resistance ARO:3007306 phosphonoformate Phosphonoformate, also known as Forscarnet or Foscavir, is an antiviral drug used to treat Herpesviridae infections. It has also been shown to inhibit the fosfomycin thiol transferase fosA. PMID:15504029 PMID:28993329 Phosphonoacetate is an experimental inhibitor of the fosfomycin thiol transferase fosA. pubchem.compound:546 antibiotic_resistance ARO:3007307 phosphonoacetate Phosphonoacetate is an experimental inhibitor of the fosfomycin thiol transferase fosA. PMID:15504029 Phosphonoacetate is an experimental inhibitor of the fosfomycin thiol transferase fosA. pubchem.compound:490 antibiotic_resistance ARO:3007308 acetylphosphonate Phosphonoacetate is an experimental inhibitor of the fosfomycin thiol transferase fosA. PMID:15504029 Quercetin is a common plant flavonoid that has shown inhibitory activity against certain aminoglycoside inactivation enzymes. Quercetin is also able to inhibit antbiotic efflux pumps such as AcrAB-TolC. pubchem.compound:5280343 antibiotic_resistance ARO:3007309 quercetin Quercetin is a common plant flavonoid that has shown inhibitory activity against certain aminoglycoside inactivation enzymes. Quercetin is also able to inhibit antbiotic efflux pumps such as AcrAB-TolC. PMID:23758273 PMID:31755586 Aranorosin is a plant derived compound that has shown inhibitory activity against certain aminoglycoside inactivation enzymes. pubchem.compound:6444217 antibiotic_resistance ARO:3007310 aranorosin Aranorosin is a plant derived compound that has shown inhibitory activity against certain aminoglycoside inactivation enzymes. PMID:22760297 Pterostilbene is a stilbenoid compound with antioxidant effects found in members of the genus Vaccinium (blueberries). It has also been shown to partially inhibit the mobile colistin resistance gene MCR-1. pubchem.compound:5281727 antibiotic_resistance ARO:3007311 pterostilbene Pterostilbene is a stilbenoid compound with antioxidant effects found in members of the genus Vaccinium (blueberries). It has also been shown to partially inhibit the mobile colistin resistance gene MCR-1. PMID:29339386 SPR741 is an experimental cationic peptide used to increase permeability of the outer membrane of Gram-negative bacteria. It is currently in clinical trials in combination with a variety of antibiotics. pubchem.compound:53323381 antibiotic_resistance ARO:3007312 SPR741 SPR741 is an experimental cationic peptide used to increase permeability of the outer membrane of Gram-negative bacteria. It is currently in clinical trials in combination with a variety of antibiotics. PMID:28947471 KL-L9P is an experimental peptide used to increase the permeability of Gram-negative bacterial membranes to enhance the entry of antibiotics such as linezolid, rifampicin, and clarithromycin. pubchem.compound:162646782 antibiotic_resistance ARO:3007313 KL-L9P KL-L9P is an experimental peptide used to increase the permeability of Gram-negative bacterial membranes to enhance the entry of antibiotics such as linezolid, rifampicin, and clarithromycin. PMID:33205989 Pentamidine is an antiparasitic compound used to treat a variety of infections such as African trypanosomiasis and leishamaniasis. It has also been shown to increase Gram-negative membrane permeability and enhance the entry of certain antibiotics. Pentamidine combined with linezolid had significant synergistic antibacterial effects against carbapenem-resistant Enterobacteriaceae pentamidine. The antimicrobial disrupts the outer membranes, dissipates the membrane potentials, and devitalizes the efflux pumps of CRE, thereby facilitating the intracellular accumulation of linezolid and reactive oxygen species (ROS), which ultimately kills the bacteria. pubchem.compound:4735 Nebupent Pentam antibiotic_resistance ARO:3007314 pentamidine Pentamidine is an antiparasitic compound used to treat a variety of infections such as African trypanosomiasis and leishamaniasis. It has also been shown to increase Gram-negative membrane permeability and enhance the entry of certain antibiotics. Pentamidine combined with linezolid had significant synergistic antibacterial effects against carbapenem-resistant Enterobacteriaceae pentamidine. The antimicrobial disrupts the outer membranes, dissipates the membrane potentials, and devitalizes the efflux pumps of CRE, thereby facilitating the intracellular accumulation of linezolid and reactive oxygen species (ROS), which ultimately kills the bacteria. PMID:28263303 MAC-0568743 is an experimental compound that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of large-scaffold antibiotics. pubchem.compound:2977394 antibiotic_resistance ARO:3007315 MAC-0568743 MAC-0568743 is an experimental compound that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of large-scaffold antibiotics. PMID:33974796 Liproxstatin-1 is a ferroptosis inhibitor that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of large-scaffold antibiotics. pubchem.compound:135735917 antibiotic_resistance ARO:3007316 liproxstatin-1 Liproxstatin-1 is a ferroptosis inhibitor that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of large-scaffold antibiotics. PMID:33974796 D-LANA-14 is a d-lysine conjugated aliphatic norspermidine analogue that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of antibiotics. It is also able to inhibit the formation of bacterial biofilms. pubchem.compound:140787320 antibiotic_resistance ARO:3007317 D-LANA14 D-LANA-14 is a d-lysine conjugated aliphatic norspermidine analogue that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of antibiotics. It is also able to inhibit the formation of bacterial biofilms. PMID:28225264 PMID:31646866 Metformin is a first-line medication for type 2 diabetes. It has been shown to increase Gram-negative membrane permeability and enhance the entry of certain antibiotics, such as tetracyclines, beta-lactams, and rifampicin. Metformin is also able to inhibit antibiotic efflux pumps such as AcrAB-TolC and MdtK. pubchem.compound:4091 Glucophage antibiotic_resistance ARO:3007318 metformin Metformin is a first-line medication for type 2 diabetes. It has been shown to increase Gram-negative membrane permeability and enhance the entry of certain antibiotics, such as tetracyclines, beta-lactams, and rifampicin. Metformin is also able to inhibit antibiotic efflux pumps such as AcrAB-TolC and MdtK. PMID:32596101 PMID:34007223 Bicarbonate is an ion capable of increasing bacterial membrane permeability by altering the proton motive force. This enhances the entry of antibiotics. pubchem.compound:769 antibiotic_resistance ARO:3007319 bicarbonate Bicarbonate is an ion capable of increasing bacterial membrane permeability by altering the proton motive force. This enhances the entry of antibiotics. PMID:29264917 PMID:32898415 Phenylalanine-arginine beta-naphthylamide is a widely-used experimental efflux pump inhibitor. It has also been shown to increase Gram-negative membrane permeability and enhance the entry of antibiotics, even in efflux pump deficient strains. It is also able to inhibit the formation of bacterial biofilms and disrupt quorum sensing. pubchem.compound:443301 antibiotic_resistance ARO:3007320 phenylalanine-arginine beta-naphthylamide Phenylalanine-arginine beta-naphthylamide is a widely-used experimental efflux pump inhibitor. It has also been shown to increase Gram-negative membrane permeability and enhance the entry of antibiotics, even in efflux pump deficient strains. It is also able to inhibit the formation of bacterial biofilms and disrupt quorum sensing. PMID:23544160 PMID:33889361 Compounds which inhibit the removal of antibiotics by the tetK efflux pump. antibiotic_resistance ARO:3007321 inhibitors of tetK efflux pump Compounds which inhibit the removal of antibiotics by the AcrAB-TolC efflux pump. antibiotic_resistance ARO:3007322 inhibitors of AcrAB-TolC efflux pump Compounds which inhibit the removal of antibiotics by the MdeA efflux pump. antibiotic_resistance ARO:3007323 inhibitors of MdeA efflux pump Compounds which inhibit the removal of antibiotics by the Rv1258c (Tap) efflux pump. antibiotic_resistance ARO:3007324 inhibitors of Rv1258c efflux pump Compounds which inhibit the removal of antibiotics by the NorA efflux pump. antibiotic_resistance ARO:3007325 inhibitors of NorA efflux pump Compounds which inhibit the removal of antibiotics by the CmeABC efflux pump. antibiotic_resistance ARO:3007326 inhibitors of CmeABC efflux pump Compounds which inhibit the removal of antibiotics by the MexAB-OprM efflux pump. antibiotic_resistance ARO:3007327 inhibitors of MexAB-OprM efflux pump Compounds which inhibit the removal of antibiotics by the MdtK efflux pump. antibiotic_resistance ARO:3007328 inhibitors of MdtK efflux pump Baicalin is a flavonoid compound that is able to inhibit the activity of tetK and MsrA antibiotic efflux pumps. It is also able to inhibit the formation of bacterial biofilms and disrupt quorum sensing. pubchem.compound:5281605 baicalein antibiotic_resistance ARO:3007329 baicalin Baicalin is a flavonoid compound that is able to inhibit the activity of tetK and MsrA antibiotic efflux pumps. It is also able to inhibit the formation of bacterial biofilms and disrupt quorum sensing. PMID:28453568 PMID:31921008 Reserpine is an alkaloid compound that is able to inhibit the activity of the AcrAB-TolC antibiotic efflux system. pubchem.compound:5770 antibiotic_resistance ARO:3007330 reserpine Reserpine is an alkaloid compound that is able to inhibit the activity of the AcrAB-TolC antibiotic efflux system. PMID:31397441 Piperine is an alkaloid compound that is able to inhibit the activity of NorA, MdeA, and Rv1258c (Tap) antibiotic efflux pumps. pubchem.compound:638024 antibiotic_resistance ARO:3007331 piperine Piperine is an alkaloid compound that is able to inhibit the activity of NorA, MdeA, and Rv1258c (Tap) antibiotic efflux pumps. PMID:18848780 PMID:21680766 Piperidine is an alkaloid compound that is able to inhibit the activity of the NorA antibiotic efflux pump. pubchem.compound:8082 antibiotic_resistance ARO:3007332 piperidine Piperidine is an alkaloid compound that is able to inhibit the activity of the NorA antibiotic efflux pump. PMID:18848780 Verapamil is a blood-pressure medication that acts by blocking calcium channels. It is also able to inhibit the antibiotic efflux pump Rv1258c (Tap). pubchem.compound:2520 antibiotic_resistance ARO:3007333 verapamil Verapamil is a blood-pressure medication that acts by blocking calcium channels. It is also able to inhibit the antibiotic efflux pump Rv1258c (Tap). PMID:24532601 Norverapamil is a metabolite of verapamil that is able to inhibit the antibiotic efflux pump Rv1258c (Tap). pubchem.compound:104972 antibiotic_resistance ARO:3007334 norverapamil Norverapamil is a metabolite of verapamil that is able to inhibit the antibiotic efflux pump Rv1258c (Tap). PMID:24532601 Chlorpromazine is a medication used to treat disorders such as schizophrenia. It is also able to inhibit bacterial antibiotic efflux pumps such as AcrAB-TolC. pubchem.compound:2726 Largactil Thorazine antibiotic_resistance ARO:3007335 chlorpromazine Chlorpromazine is a medication used to treat disorders such as schizophrenia. It is also able to inhibit bacterial antibiotic efflux pumps such as AcrAB-TolC. PMID:32487753 Amitriptyline is an antidepressant used to treat a variety of conditions such as cyclic vomiting syndrome, major depressive disorder, fibromyalgia. Is is also able to inhibit bacterial antibiotic efflux pumps such as AcrAB-TolC. pubchem.compound:2160 Elavil antibiotic_resistance ARO:3007336 amitriptyline Amitriptyline is an antidepressant used to treat a variety of conditions such as cyclic vomiting syndrome, major depressive disorder, fibromyalgia. Is is also able to inhibit bacterial antibiotic efflux pumps such as AcrAB-TolC. PMID:32487753 Thioridazine is a phenothiazine drug used in the treatment of schizophrenia and psychosis. It is also able to inhibit mycobacterial antibiotic efflux pumps and the formation of bacterial biofilms. pubchem.compound:5452 antibiotic_resistance ARO:3007337 thioridazine Thioridazine is a phenothiazine drug used in the treatment of schizophrenia and psychosis. It is also able to inhibit mycobacterial antibiotic efflux pumps and the formation of bacterial biofilms. PMID:18836028 PMID:32312774 Biochanin A is a flavonoid compound that is able to inhibit mycobacterial antibiotic efflux pumps. pubchem.compound:5280373 antibiotic_resistance ARO:3007338 biochanin A Biochanin A is a flavonoid compound that is able to inhibit mycobacterial antibiotic efflux pumps. PMID:28964936 Phloretin is a plant-derived phenol that is able to inhibit the antibiotic efflux pump NorA. pubchem.compound:4788 antibiotic_resistance ARO:3007339 phloretin Phloretin is a plant-derived phenol that is able to inhibit the antibiotic efflux pump NorA. PMID:34833994 Epigallocatechin gallate is a flavonol that is able to inhibit antibiotic efflux pumps such as CmeABC, NorA, and tetK. pubchem.compound:65064 antibiotic_resistance ARO:3007340 epigallocatechin gallate Epigallocatechin gallate is a flavonol that is able to inhibit antibiotic efflux pumps such as CmeABC, NorA, and tetK. PMID:15155186 PMID:15643566 Hesperetin is a flavonoid compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:72281 antibiotic_resistance ARO:3007341 hesperetin Hesperetin is a flavonoid compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Naringenin is a flavonoid compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:932 antibiotic_resistance ARO:3007342 naringenin Naringenin is a flavonoid compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Sophoraflavanone G is a phytoncide derived from members of the Sophora genus. It is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:72936 antibiotic_resistance ARO:3007343 sophoraflavanone G Sophoraflavanone G is a phytoncide derived from members of the Sophora genus. It is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Chrysoeriol is a derivative of the flavone luteolin. It has been shown to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:5280666 antibiotic_resistance ARO:3007344 chrysoeriol Chrysoeriol is a derivative of the flavone luteolin. It has been shown to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Sideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:3083788 antibiotic_resistance ARO:3007345 sideroxylin Sideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:22814821 6-desmethylsideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:56665369 antibiotic_resistance ARO:3007346 6-desmethylsideroxylin 6-desmethylsideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:22814821 8-desmethylsideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:44258359 antibiotic_resistance ARO:3007347 8-desmethylsideroxylin 8-desmethylsideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:22814821 Diosmetin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:5281612 antibiotic_resistance ARO:3007348 diosmetin Diosmetin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Chrysoplenetin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:5281608 antibiotic_resistance ARO:3007349 chrysosplenetin Chrysoplenetin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Galangin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:5281616 antibiotic_resistance ARO:3007350 galangin Galangin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Kaempferol is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:5280863 antibiotic_resistance ARO:3007351 kaempferol Kaempferol is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Kaempferol rhamnoside is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:44259088 antibiotic_resistance ARO:3007352 kaempferol rhamnoside Kaempferol rhamnoside is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Myricitrin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:5281673 antibiotic_resistance ARO:3007353 myricitrin Myricitrin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Pendeuletin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:5320462 antibiotic_resistance ARO:3007354 penduletin Pendeuletin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Tiliroside is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:5320686 antibiotic_resistance ARO:3007355 tiliroside Tiliroside is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Daidzein is a flavonolignan compound found in soybeans and other legumes. It has been shown to inhibit antibiotic efflux pumps such as AcrAB-TolC and MexAB-OprM. pubchem.compound:5281708 antibiotic_resistance ARO:3007356 daidzein Daidzein is a flavonolignan compound found in soybeans and other legumes. It has been shown to inhibit antibiotic efflux pumps such as AcrAB-TolC and MexAB-OprM. PMID:34833994 Genistein is a flavonolignan compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:5280961 antibiotic_resistance ARO:3007357 genistein Genistein is a flavonolignan compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:32923005 Orobol is a flavonolignan compound that is able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:5281801 antibiotic_resistance ARO:3007358 orobol Orobol is a flavonolignan compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:32923005 MBX-2319 is an experimental compound used to inhibit the AcrAB-TolC antibiotic efflux system. pubchem.compound:1289417 antibiotic_resistance ARO:3007359 MBX-2319 MBX-2319 is an experimental compound used to inhibit the AcrAB-TolC antibiotic efflux system. PMID:25114133 Capsaicin is a compound found in chili peppers and is used to treat nerve pain. It is also able to inhibit antibiotic efflux pumps such as NorA. pubchem.compound:1548943 antibiotic_resistance ARO:3007360 capsaicin Capsaicin is a compound found in chili peppers and is used to treat nerve pain. It is also able to inhibit antibiotic efflux pumps such as NorA. PMID:22807321 Rutin is a plant pigment that is able to inhibit bacterial biofilm formation. pubchem.compound:5280805 antibiotic_resistance ARO:3007361 rutin Rutin is a plant pigment that is able to inhibit bacterial biofilm formation. PMID:34456739 Citral is a monoterpene aldehyde derived from a variety of plant oils that is able to inhibit bacterial biofilm formation and quorum sensing. pubchem.compound:638011 antibiotic_resistance ARO:3007362 citral Citral is a monoterpene aldehyde derived from a variety of plant oils that is able to inhibit bacterial biofilm formation and quorum sensing. PMID:33392626 Furanone is a heterocyclic organic compound that disrupts bacterial quorum sensing. pubchem.compound:140765 antibiotic_resistance ARO:3007363 furanone Furanone is a heterocyclic organic compound that disrupts bacterial quorum sensing. PMID:31971503 A mixture of the beta-lactam antibiotic cefepime and the beta-lactamase inhibitor tazobactam. pubchem.compound:9567558 antibiotic_resistance ARO:3007364 cefepime-tazobactam A mixture of the beta-lactam antibiotic cefepime and the beta-lactamase inhibitor tazobactam. PMID:33716176 A mixture of the beta-lactam antibiotic cepefime and the beta-lactamase inhibitor enmetazobactam. antibiotic_resistance ARO:3007365 cefepime-enmetazobactam A mixture of the beta-lactam antibiotic cepefime and the beta-lactamase inhibitor enmetazobactam. PMID:35471043 A mixture of the beta-lactam antibiotic aztreonam and the beta-lactamase inhibitor avibactam. antibiotic_resistance ARO:3007366 aztreonam-avibactam A mixture of the beta-lactam antibiotic aztreonam and the beta-lactamase inhibitor avibactam. PMID:35760303 L-CS319 is an experimental bisthiazolidine metallo-beta-lactamase inhibitor capable of inhibiting the action of NDM-1. pubchem.compound:76936796 antibiotic_resistance ARO:3007367 L-CS319 L-CS319 is an experimental bisthiazolidine metallo-beta-lactamase inhibitor capable of inhibiting the action of NDM-1. PMID:27623409 FosG is a glutathione transferase that confers resistance to fosfomycin. FosG antibiotic_resistance ARO:3007368 FosG FosG is a glutathione transferase that confers resistance to fosfomycin. PMID:33199384 FosG FosH is a hydrolase that confers resistance to fosfomycin. FosH antibiotic_resistance ARO:3007369 FosH FosH is a hydrolase that confers resistance to fosfomycin. PMID:33199384 FosH FosI is a fosfomycin resistance gene. FosI antibiotic_resistance ARO:3007370 FosI FosI is a fosfomycin resistance gene. PMID:26552984 FosI FosA8 is a plasmid-located fosfomycin resistance gene. FosA8 antibiotic_resistance ARO:3007371 FosA8 FosA8 is a plasmid-located fosfomycin resistance gene. PMID:31481445 FosA8 FosBx1 is a fosfomycin resistance gene. FosBx1 antibiotic_resistance ARO:3007372 FosBx1 FosBx1 is a fosfomycin resistance gene. PMID:33199384 FosBx1 A family of subclass B3 metallo-beta-lactamases with activity against a range of beta-lactam antibiotics. antibiotic_resistance ARO:3007373 PJM beta-lactamase A family of subclass B3 metallo-beta-lactamases with activity against a range of beta-lactam antibiotics. PMID:35943258 PJM-1 is a chromosomally-encoded subclass B3 metallo-beta-lactamase found in P. japonensis confering resistance to a range of antibiotics including ampicillin, cefalotin, and cefoxitin. PJM-1 antibiotic_resistance ARO:3007374 PJM-1 PJM-1 is a chromosomally-encoded subclass B3 metallo-beta-lactamase found in P. japonensis confering resistance to a range of antibiotics including ampicillin, cefalotin, and cefoxitin. PMID:35943258 PJM-1 KPC-87 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia. KPC-87 antibiotic_resistance ARO:3007375 KPC-87 KPC-87 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia. PMID:36003991 KPC-87 Gentamicin X is an aminoglycoside antibiotic. It is a precursor of gentamicin C and a minor component of the gentamicin antibiotic mixture. pubchem.compound:15574862 gentamicin X2 antibiotic_resistance ARO:3007376 gentamicin X Gentamicin X is an aminoglycoside antibiotic. It is a precursor of gentamicin C and a minor component of the gentamicin antibiotic mixture. PMID:25641167 6'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. pubchem.compound:15344654 antibiotic_resistance ARO:3007377 6'-N-ethylnetilmicin 6'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. PMID:8385262 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. pubchem.compound:101649392 antibiotic_resistance ARO:3007378 2'-N-ethylnetilmicin 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. PMID:8385262 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. pubchem.compound:65453 pentisomicin antibiotic_resistance ARO:3007379 5-episisomicin 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. PMID:697347 Resistance-conferring genetic elements encoding proteins involved in the enzymatic inactivation of aminoglycoside antibiotics through chemical modification. antibiotic_resistance ARO:3007380 aminoglycoside modifying enzyme KPC-86 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia. KPC-86 antibiotic_resistance ARO:3007381 KPC-86 KPC-86 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia. PMID:36003991 KPC-86 Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). pubchem.compound:3467 Cidomycin Garamycin Gentacycol Gentamicins Gentamicinum Gentavet antibiotic_resistance ARO:3007382 gentamicin Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). PMID:28507482 KPC-95 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia. KPC-95 antibiotic_resistance ARO:3007383 KPC-95 KPC-95 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia. PMID:35038557 KPC-95 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007384 AAC(3)-I A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007385 AAC(3)-II A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin, tobramycin and kanamycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007386 AAC(3)-III A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin, tobramycin and kanamycin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin, tobramycin and apramycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007387 AAC(3)-IV A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin, tobramycin and apramycin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin and ethylnetilmicin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007388 AAC(3)-VI A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin and ethylnetilmicin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate paronomycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007389 AAC(3)-VII A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate neomycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007390 AAC(3)-VIII A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate neomycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007391 AAC(3)-IX A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate kanamycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007392 AAC(3)-X A family of aminoglycoside 2'-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007393 AAC(2')-I A family of aminoglycoside 2'-N-acetyltransferase enzymes which inactivate kasugamycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007394 AAC(2')-II A family of aminoglycoside 6'-N-acetyltransferase enzymes which inactivate amikacin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007395 AAC(6')-I A family of aminoglycoside 6'-N-acetyltransferase enzymes which inactivate amikacin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 A family of aminoglycoside 6'-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007396 AAC(6')-II A family of aminoglycoside 6'-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 SIR is a revised system for antibiotic sensitivity testing in Sweden that was proposed in 1977. The SIR system included two main changes: three sensitivity groups instead of the previous four and new breakpoints for the sensitivity groups. antibiotic_resistance ARO:3007397 Swedish Reference Group for Antibiotics (SIR) SIR is a revised system for antibiotic sensitivity testing in Sweden that was proposed in 1977. The SIR system included two main changes: three sensitivity groups instead of the previous four and new breakpoints for the sensitivity groups. DOI:10.3109/inf.1981.13.issue-2.13 The WRG is a standardized antimicrobial susceptibility testing methodology created by the Dutch Commissie Richtlijnen Gevoeligheidsbepalingen in 1981. Commissie Richtlijnen Gevoeligheidsbepalingen (CRG) Committee Guidelines Susceptibility Testing Working Group Guidelines Susceptibility Testing antibiotic_resistance ARO:3007398 Werkgroep Richtlijnen Gevoeligheidsbepalingen (WRG) The WRG is a standardized antimicrobial susceptibility testing methodology created by the Dutch Commissie Richtlijnen Gevoeligheidsbepalingen in 1981. DOI:10.1007/bf01964289 A family of aminoglycoside 6-O-nucleotidyltransferase enzymes which inactivate streptomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007399 ANT(6)-I A family of aminoglycoside 6-O-nucleotidyltransferase enzymes which inactivate streptomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. PMID:20833577 PMID:8385262 A family of aminoglycoside 9-O-nucleotidyltransferase enzymes which inactivate spectinomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007400 ANT(9)-I A family of aminoglycoside 9-O-nucleotidyltransferase enzymes which inactivate spectinomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. PMID:20833577 PMID:8385262 A plasmid-borne ANT(9)-I variant identified from Enterococcus faecalis. ANT(9)-Ib confers resistance to spectinomycin through enzymatic inactivation. ANT(9)-Ib antibiotic_resistance ARO:3007401 ANT(9)-Ib A plasmid-borne ANT(9)-I variant identified from Enterococcus faecalis. ANT(9)-Ib confers resistance to spectinomycin through enzymatic inactivation. PMID:1659306 ANT(9)-Ib KPC-94 is a mutated carbapenemase allele found in Klebsiella pneumoniae. KPC-94 antibiotic_resistance ARO:3007402 KPC-94 KPC-94 is a mutated carbapenemase allele found in Klebsiella pneumoniae. PMID:35038557 KPC-94 A family of aminoglycoside 4'-O-nucleotidyltransferase enzymes which inactivate amikacin, tobramycin & dibekacin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007403 ANT(4')-I A family of aminoglycoside 4'-O-nucleotidyltransferase enzymes which inactivate amikacin & tobramycin, but not dibekacin, by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007404 ANT(4')-II A family of aminoglycoside 2''-O-nucleotidyltransferase enzymes which inactivate gentamicin, tobramycin & dibekacin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007405 ANT(2'')-I A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kamamycin, neomycin & lividomycin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007406 APH(3')-I A family of aminoglycoside O-nucleotidyltransferase enzymes which inactivate streptomycin and spectinomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. These enzymes modify the 3''-hydroxyl position of streptomycin and the 9-hydroxyl position of spectinomycin. antibiotic_resistance ARO:3007407 ANT(3'')-I A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin, neomycin, paromomycin and butirosin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007408 APH(3')-II A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin, neomycin, paromomycin, butirosin and lividomycin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007409 APH(3')-III A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin, neomycin, paromomycin, ribostamycin and butirosin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007410 APH(3')-IV A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate neomycin, paromomycin and ribostamycin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007411 APH(3')-V A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin, neomycin, paromomycin, ribostamycin and butirosin, as well as amikacin and isepomicin, by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007412 APH(3')-VI A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin and neomycin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. It is also possible to observe low-level sub-breakpoint amikacin resistance dependent on testing standards and breakpoint criteria. antibiotic_resistance ARO:3007413 APH(3')-VII A family of aminoglycoside 3''-O-phosphotransferase enzymes which inactivate streptomycin by catalyzing the ATP-dependent phosphorylation of the 3''-hydroxyl group, thereby conferring resistance. antibiotic_resistance ARO:3007414 APH(3'')-I A family of aminoglycoside 6-O-phosphotransferase enzymes which inactivate streptomycin by catalyzing the ATP-dependent phosphorylation of the 6-hydroxyl group, thereby conferring resistance. antibiotic_resistance ARO:3007415 APH(6)-I A family of aminoglycoside 9-O-phosphotransferase enzymes which inactivate spectinomycin by catalyzing the ATP-dependent phosphorylation of the 9-hydroxyl group, thereby conferring resistance. antibiotic_resistance ARO:3007416 APH(9)-I A family of aminoglycoside 7''-O-phosphotransferase enzymes which inactivate hygromycin by catalyzing the ATP-dependent phosphorylation of the 7''-hydroxyl group, thereby conferring resistance. antibiotic_resistance ARO:3007417 APH(7'')-I A family of aminoglycoside 4-O-phosphotransferase enzymes which inactivate hygromycin by catalyzing the ATP-dependent phosphorylation of the 4-hydroxyl group, thereby conferring resistance. antibiotic_resistance ARO:3007418 APH(4)-I Bifunctional aminoglycoside-inactivating enzymes composed of two separate functional domains. These proteins possess activity from both enzyme components, thereby conferring resistance to the combination of antibiotics from both domains, and may include acetylation, phosphorylation or nucleotidylation activity. antibiotic_resistance ARO:3007419 aminoglycoside bifunctional resistance protein LamB is a maltoporin that negatively regulates antibiotic resistance. Knockout strains of lamB are shown to exhibit higher levels of resistance than wild-type strains. Mutations in the lamB gene of Klebsiella are associated with resistance to ceftazidime-avibactam. Kpne_lamB_CZA antibiotic_resistance ARO:3007420 Klebsiella pneumoniae lamB with mutations conferring resistance to ceftazidime-avibactam LamB is a maltoporin that negatively regulates antibiotic resistance. Knockout strains of lamB are shown to exhibit higher levels of resistance than wild-type strains. Mutations in the lamB gene of Klebsiella are associated with resistance to ceftazidime-avibactam. PMID:34551677 Kpne_lamB_CZA Mutant PBP3 in Klebsiella pneumoniae conferring resistance to ceftazidime-avibactam. Kpne_PBP3_BLA antibiotic_resistance ARO:3007421 Klebsiella pneumoniae PBP3 mutants conferring resistance to ceftazidime-avibactam Mutant PBP3 in Klebsiella pneumoniae conferring resistance to ceftazidime-avibactam. PMID:34551677 Kpne_PBP3_BLA A combiation of the beta-lactam antibiotic ceftaroline and the beta-lactamase inhibitor avibactam. antibiotic_resistance ARO:3007422 ceftaroline-avibactam A combiation of the beta-lactam antibiotic ceftaroline and the beta-lactamase inhibitor avibactam. PMID:22441578 Mutant PBP3 in E. coli conferring resistance to beta-lactams, including beta-lactam/beta-lactamase inhibitor combinations. Ecol_PBP3_BLA antibiotic_resistance ARO:3007423 Escherichia coli PBP3 mutants conferring resistance to beta-lactam antibiotics Mutant PBP3 in E. coli conferring resistance to beta-lactams, including beta-lactam/beta-lactamase inhibitor combinations. PMID:25634992 PMID:28559260 Ecol_PBP3_BLA Resistance via uptake of host nutrients to bypass antibiotic mechanism. antibiotic_resistance ARO:3007424 resistance by host-dependent nutrient acquisition Resistance via uptake of host nutrients to bypass antibiotic mechanism. PMID:36450721 Proteins involved in the uptake of host-nutrients to bypass antibiotic resistance mechanisms. antibiotic_resistance ARO:3007425 protein(s) conferring resistance via host-dependent nutrient acquisition ECF transporter S component genes involved in host nutrient uptake. antibiotic_resistance ARO:3007426 ECF transporter S component ECF transporter S component genes involved in host nutrient uptake. PMID:36450721 ThfT is an ECF transporter S component that expands the substrate profile of endogenous ECF transporters to include folate biosynthesis end products. It confers resistance to the folate synthesis inhibitor sulfamethoxazole by allowing uptake of host folate. ThfT antibiotic_resistance ARO:3007427 ThfT ThfT is an ECF transporter S component that expands the substrate profile of endogenous ECF transporters to include folate biosynthesis end products. It confers resistance to the folate synthesis inhibitor sulfamethoxazole by allowing uptake of host folate. PMID:36450721 ThfT Operon or gene clusters confering resistance to polymyxin antibiotics. antibiotic_resistance ARO:3007428 polymyxin resistance operon Operon or gene clusters confering resistance to polymyxin antibiotics. PMID:25068415 Various genes and proteins involved in intrinsic polymyxin resistance operons. antibiotic_resistance ARO:3007429 gene(s) or protein(s) associated with polymyxin resistance operon Glycyl carrier proteins associated with polymixin resistance operons. antibiotic_resistance ARO:3007430 alm glycyl carrier protein Glycyl carrier proteins associated with polymixin resistance operons. PMID:25068415 almF is a glycine carrier protein associated with the almEFG operon in Vibrio cholerae. It is activated by almE and carries the glycyl molecule later added to lipid A by almG. almF antibiotic_resistance ARO:3007431 almF almF is a glycine carrier protein associated with the almEFG operon in Vibrio cholerae. It is activated by almE and carries the glycyl molecule later added to lipid A by almG. PMID:25068415 almF Glycyl transferase associated with polymyxin resistance operons not interacting with lipid A. antibiotic_resistance ARO:3007432 alm glycyltransferase Glycyl transferase associated with polymyxin resistance operons not interacting with lipid A. PMID:25068415 almE is a glycyltransferase found in Vibrio cholerae that transfers glycine to the carrier protein almF. almE is part of the almEFG polymyxin resistance operon. almE antibiotic_resistance ARO:3007433 almE almE is a glycyltransferase found in Vibrio cholerae that transfers glycine to the carrier protein almF. almE is part of the almEFG polymyxin resistance operon. PMID:25068415 almE The almEFG operon is responsible for glycylation of lipid A as a mechanism of colistin resistance in Vibrio cholerae. Its mechanism involves transfer of a glycyl molecule to the carrier protein almF by almE followed by glycylation of lipid A by almG. almEFG antibiotic_resistance ARO:3007434 almEFG The almEFG operon is responsible for glycylation of lipid A as a mechanism of colistin resistance in Vibrio cholerae. Its mechanism involves transfer of a glycyl molecule to the carrier protein almF by almE followed by glycylation of lipid A by almG. PMID:25068415 almEFG WUS-1 is a WUS beta-lactamase. WUS-1 antibiotic_resistance ARO:3007435 WUS-1 WUS-1 is a WUS beta-lactamase. PMID:36532482 WUS-1 KPC-96 is a KPC beta-lactamase. KPC-96 antibiotic_resistance ARO:3007436 KPC-96 KPC-96 EBR-5 is an EBR beta-lactamase. EBR-5 antibiotic_resistance ARO:3007437 EBR-5 EBR-5 is an EBR beta-lactamase. PMID:36719228 EBR-5 LAQ-1 beta lactamase is a class C beta lactamase. LAQ-1 antibiotic_resistance ARO:3007438 LAQ-1 LAQ-1 beta lactamase is a class C beta lactamase. PMID:36504772 LAQ-1 SSA beta-lactamases are a family of Class A beta-lactamases. antibiotic_resistance ARO:3007439 SSA beta-lactamase SSA beta-lactamases are a family of Class A beta-lactamases. PMID:36626997 WUS is a family of the metallo-beta-lactamases. antibiotic_resistance ARO:3007440 WUS beta-lactamase WUS is a family of the metallo-beta-lactamases. PMID:36532482 LAQ is a class C beta lactamase. antibiotic_resistance ARO:3007441 LAQ beta lactamase LAQ is a class C beta lactamase. PMID:36504772 SSA is an SSA beta lactamase. SSA antibiotic_resistance ARO:3007442 SSA SSA is an SSA beta lactamase. PMID:36626997 SSA NDM-44 is a subclass B1 NDM metallo-beta-lactamase. NDM-44 antibiotic_resistance ARO:3007443 NDM-44 NDM-44 NDM-45 is a NDM class B metallo beta-lactamase. NDM-45 antibiotic_resistance ARO:3007444 NDM-45 NDM-45 NDM-46 is an NDM metallo-beta-lactamase. NDM-46 antibiotic_resistance ARO:3007445 NDM-46 NDM-46 KPC-100 is an inhibitor-resistant carbapenem-hydrolyzing KPC beta-lactamase. KPC-100 antibiotic_resistance ARO:3007446 KPC-100 KPC-100 NDM-47 is a NDM metallo-beta-lactamase. NDM-47 antibiotic_resistance ARO:3007447 NDM-47 NDM-47 TEM-246 is a class A TEM beta-lactamase found in Neisseria gonorrhoeae. TEM-246 antibiotic_resistance ARO:3007448 TEM-246 TEM-246 KPC-97 is a KPC class A beta-lactamase. KPC-97 antibiotic_resistance ARO:3007449 KPC-97 KPC-97 KPC-98 is a KPC beta-lactamase. KPC-98 antibiotic_resistance ARO:3007450 KPC-98 KPC-98 TEM-247 is a TEM class A beta-lactamase. TEM-247 antibiotic_resistance ARO:3007451 TEM-247 TEM-247 KPC-99 is a KPC class A beta-lactamase. KPC-99 antibiotic_resistance ARO:3007452 KPC-99 KPC-99 TEM-244 is a TEM beta-lactamase. TEM-244 antibiotic_resistance ARO:3007453 TEM-244 TEM-244 TEM-245 is a TEM class A beta-lactamase. TEM-245 antibiotic_resistance ARO:3007454 TEM-245 TEM-245 Cethromycin is a ketolide (macrolide) antibiotic, with a similar mechanism to telithromycin, with activity against selected gram-positive, gram-negative, atypical bacteria, and even designed for tularemia, plague, and anthrax prophylaxis. pubchem.compound:447451 antibiotic_resistance ARO:3007455 cethromycin Cethromycin is a ketolide (macrolide) antibiotic, with a similar mechanism to telithromycin, with activity against selected gram-positive, gram-negative, atypical bacteria, and even designed for tularemia, plague, and anthrax prophylaxis. PMID:37081393 dfrL is a gene encoding a trimethoprim-resistant dihydrofolate reductase (DHFR) identified in Staphylococcus aureus. dfrL antibiotic_resistance ARO:3007456 dfrL dfrL is a gene encoding a trimethoprim-resistant dihydrofolate reductase (DHFR) identified in Staphylococcus aureus. PMID:36935372 dfrL Carrimycin is a macrolide antibiotic produced by genetically engineered Streptomyces spiramyceticus and may be active against some Gram-positive bacteria and Mycobacterium tuberculosis. bitespiramycin antibiotic_resistance ARO:3007457 carrimycin Carrimycin is a macrolide antibiotic produced by genetically engineered Streptomyces spiramyceticus and may be active against some Gram-positive bacteria and Mycobacterium tuberculosis. PMID:37113529 Cefovecin is a new extended-spectrum semisynthetic cephalosporin indicated for the treatment of a broad-spectrum of Gram-positive and Gram-negative bacterial infections in dogs and cats. pubchem.compound:6336480 antibiotic_resistance ARO:3007458 cefovecin Cefovecin is a new extended-spectrum semisynthetic cephalosporin indicated for the treatment of a broad-spectrum of Gram-positive and Gram-negative bacterial infections in dogs and cats. PMID:37107106 EstT is a gene encoding for a serine-dependent macrolide alpha/beta-hydrolase. EstT antibiotic_resistance ARO:3007459 EstT EstT is a gene encoding for a serine-dependent macrolide alpha/beta-hydrolase. PMID:36791107 EstT IMP-91 is an IMP beta-lactamase. IMP-91 antibiotic_resistance ARO:3007460 IMP-91 IMP-91 is an IMP beta-lactamase. PMID:37092959 IMP-91 IMP-96 is an IMP beta-lactamase. IMP-96 antibiotic_resistance ARO:3007461 IMP-96 IMP-96 is an IMP beta-lactamase. PMID:37092959 IMP-96 IMP-92 is an IMP beta-lactamase. IMP-92 antibiotic_resistance ARO:3007462 IMP-92 IMP-92 IMP-93 is an IMP beta-lactamase. IMP-93 antibiotic_resistance ARO:3007463 IMP-93 IMP-93 IMP-94 is an IMP beta-lactamase. IMP-94 antibiotic_resistance ARO:3007464 IMP-94 IMP-94 IMP-95 is an IMP beta-lactamase. IMP-95 antibiotic_resistance ARO:3007465 IMP-95 IMP-95 BP2 is a novel beta-lactam-derived beta-lactamase inhibitor, efficacious when co-administered with meropenem in K. pneumoniae. antibiotic_resistance ARO:3007466 BP2 BP2 is a novel beta-lactam-derived beta-lactamase inhibitor, efficacious when co-administered with meropenem in K. pneumoniae. PMID:37106995 SUL-DUR or sulbactam-durlobactam (formerly ETX2514SUL) is a novel beta-lactam-beta-lactamase inhibitor designed specifically for the treatment of carbapenem-resistant Acinetobacter baumannii (CRAB). ETX2514SUL antibiotic_resistance ARO:3007467 sulbactam-durlobactam SUL-DUR or sulbactam-durlobactam (formerly ETX2514SUL) is a novel beta-lactam-beta-lactamase inhibitor designed specifically for the treatment of carbapenem-resistant Acinetobacter baumannii (CRAB). PMID:37052117 Sulfanilamide is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. pubchem.compound:5333 antibiotic_resistance ARO:3007468 sulfanilamide Sulfanilamide is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. PMID:37081146 Sulfamerazine is a sulfonamide anti-infective used to treat bacterial infections, such as bronchitis, prostatitis, and urinary tract infections. pubchem.compound:5325 antibiotic_resistance ARO:3007469 sulfamerazine Sulfamerazine is a sulfonamide anti-infective used to treat bacterial infections, such as bronchitis, prostatitis, and urinary tract infections. PMID:37081146 IND-17 is an IND beta-lactamase and confers resistance to ampicillin, nitrocefin, cefazolin, cefuroxime, ceftazidime, imipenem, meropenem in Chryseobacterium spp. IND-17 antibiotic_resistance ARO:3007470 IND-17 IND-17 is an IND beta-lactamase and confers resistance to ampicillin, nitrocefin, cefazolin, cefuroxime, ceftazidime, imipenem, meropenem in Chryseobacterium spp. PMID:37047008 IND-17 Narasin is polyether ionophore antibiotic. It is a derivative of salinomycin with an additional methyl group. Narasin is produced by fermentation of a strain of Streptomyces aureofaciens. pubchem.compound:65452 antibiotic_resistance ARO:3007471 narasin Narasin is polyether ionophore antibiotic. It is a derivative of salinomycin with an additional methyl group. Narasin is produced by fermentation of a strain of Streptomyces aureofaciens. PMID:37119567 Tilmicosin is a macrolide antibiotic used for livestock and poultry synthesized from tylomycin. It is mainly used to treat common bacterial infections and diseases caused by mycoplasma infection in livestock and poultry breeding. Tilmicosin has broad-spectrum antibacterial properties and has a strong inhibitory effect on most Gram positive and negative bacteria. pubchem.compound:5282521 antibiotic_resistance ARO:3007472 tilmicosin Tilmicosin is a macrolide antibiotic used for livestock and poultry synthesized from tylomycin. It is mainly used to treat common bacterial infections and diseases caused by mycoplasma infection in livestock and poultry breeding. Tilmicosin has broad-spectrum antibacterial properties and has a strong inhibitory effect on most Gram positive and negative bacteria. PMID:37110187 Amino acid substitution mutations in Mycobacterium avium gyrA observed to confer resistance to fluoroquinolone antibiotics. Mavi_gyrA_FLO antibiotic_resistance ARO:3007473 Mycobacterium avium gyrA with mutation conferring resistance to Fluoroquinolone Amino acid substitution mutations in Mycobacterium avium gyrA observed to confer resistance to fluoroquinolone antibiotics. PMID:37067420 Mavi_gyrA_FLO Contezolid is an oxazolidinone antimicrobial agent newly approved for treatment of multidrug-resistant (MDR) Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. pubchem.compound:25184541 antibiotic_resistance ARO:3007474 contezolid Contezolid is an oxazolidinone antimicrobial agent newly approved for treatment of multidrug-resistant (MDR) Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. PMID:36992830 Cefcapene is a third-generation cephalosporin in the beta-lactam class of antibiotics used to manage and treat gram-negative and gram-positive bacterial infections. pubchem.compound:6436055 antibiotic_resistance ARO:3007475 cefcapene Cefcapene is a third-generation cephalosporin in the beta-lactam class of antibiotics used to manage and treat gram-negative and gram-positive bacterial infections. PMID:36872372 Mutations to the ATPase subunit C atpE gene, which is involved with the production of ATP, confer resistance to bedaquiline by altering the antibiotic's target. Mabs_atpE_BDQ antibiotic_resistance ARO:3007476 Mycobacterium abscessus atpE with mutation conferring resistance to bedaquiline Mutations to the ATPase subunit C atpE gene, which is involved with the production of ATP, confer resistance to bedaquiline by altering the antibiotic's target. PMID:36988496 Mabs_atpE_BDQ ATP synthase enzymes, specifically subunit C, resistant to diarylquinolone antibiotics including Bedaquiline. Mutations in ATP synthase confer antibiotic resistance by disrupting binding and blocking of ATP synthase reactions by Bedaquiline. antibiotic_resistance ARO:3007477 antibiotic resistant ATP synthase ATP synthase enzymes, specifically subunit C, resistant to diarylquinolone antibiotics including Bedaquiline. Mutations in ATP synthase confer antibiotic resistance by disrupting binding and blocking of ATP synthase reactions by Bedaquiline. PMID:36988496 Darobactin A, isolated from Photorhabdus bacteria, contains a macrocyclic peptide-based ring system and exhibits selective antibiotic activity against Gram-negative pathogens in both in vitro and animal infection models and functions. pubchem.compound:155899183 antibiotic_resistance ARO:3007478 darobactin A Darobactin A, isolated from Photorhabdus bacteria, contains a macrocyclic peptide-based ring system and exhibits selective antibiotic activity against Gram-negative pathogens in both in vitro and animal infection models and functions. PMID:35926121 Caprazamycin is a potent anti-mycobacterial liponucleoside antibiotics isolated from Streptomyces sp. pubchem.compound:11332272 antibiotic_resistance ARO:3007479 caprazamycin Caprazamycin is a potent anti-mycobacterial liponucleoside antibiotics isolated from Streptomyces sp. PMID:36697788 TBI-223 is a novel oxazolidinone with potentially reduced myelosuppression, compared to linezolid. TBI-223 may be considered an additional treatment against MRSA infections and potentially other Gram-positive bacteria in humans. pubchem.compound:126494519 antibiotic_resistance ARO:3007480 TBI-223 TBI-223 is a novel oxazolidinone with potentially reduced myelosuppression, compared to linezolid. TBI-223 may be considered an additional treatment against MRSA infections and potentially other Gram-positive bacteria in humans. PMID:36106881 Pseudouridimycin is a nucleoside analogue inhibitor discovered from the soil bacterium Streptomyces sp. which has proven to be effective against multidrug-resistant S. pyogenes. pubchem.compound:72792467 antibiotic_resistance ARO:3007481 pseudouridimycin Pseudouridimycin is a nucleoside analogue inhibitor discovered from the soil bacterium Streptomyces sp. which has proven to be effective against multidrug-resistant S. pyogenes. PMID:36873015 RAD beta-lactamases are a class D beta-lactamase first identified in Riemerella anatipestifer. antibiotic_resistance ARO:3007482 RAD beta-lactamase RAD-1 is a class D RAD beta-lactamase found in Riemerella anatipestifer. RAD-1 antibiotic_resistance ARO:3007483 RAD-1 RAD-1 is a class D RAD beta-lactamase found in Riemerella anatipestifer. PMID:36883515 RAD-1 Monensin is an ionophore antibiotic isolated from Streptomyces cinnamonensis with very strong antibacterial and antiparasitic effects. pubchem.compound:441145 antibiotic_resistance ARO:3007484 monensin Monensin is an ionophore antibiotic isolated from Streptomyces cinnamonensis with very strong antibacterial and antiparasitic effects. PMID:37219624 Nigericin is an antibiotic derived from Streptomyces hygroscopicus. It is described as a potassium ionophore, which facilitates H+/K+ anti-port across cell membranes, thereby activating NLRP3 by causing potassium efflux. pubchem.compound:34230 antibiotic_resistance ARO:3007485 nigericin Nigericin is an antibiotic derived from Streptomyces hygroscopicus. It is described as a potassium ionophore, which facilitates H+/K+ anti-port across cell membranes, thereby activating NLRP3 by causing potassium efflux. PMID:37247906 Wychimicins are spirotetronates with activity against methicillin-resistant Staphylococcus aureus. antibiotic_resistance ARO:3007486 wychimicin Wychimicins are spirotetronates with activity against methicillin-resistant Staphylococcus aureus. PMID:36071214 Wychimicin A is a spirotetronate polyketides from Actinocrispum wychmicini MI503-A4. pubchem.compound:165412942 antibiotic_resistance ARO:3007487 wychimicin A Wychimicin A is a spirotetronate polyketides from Actinocrispum wychmicini MI503-A4. PMID:36071214 Wychimicin C is a spirotetronate polyketides from Actinocrispum wychmicini MI503-A4. pubchem.compound:165412941 antibiotic_resistance ARO:3007488 wychimicin C Wychimicin C is a spirotetronate polyketides from Actinocrispum wychmicini MI503-A4. PMID:36071214 A dihydrofolate reductase and trimethoprim resistance gene found on a mega-plasmid (0.4 Mb) from a Pseudomonas putida strain. dfrB10 antibiotic_resistance ARO:3007489 dfrB10 A dihydrofolate reductase and trimethoprim resistance gene found on a mega-plasmid (0.4 Mb) from a Pseudomonas putida strain. PMID:26679251 dfrB10 A dihydrofolate reductase and trimethoprim resistance gene found in a groundwater sample at the Horonobe Underground Research laboratory in Japan in 2017, in a Betaproteobacteria sequence. dfrB11 antibiotic_resistance ARO:3007490 dfrB11 A dihydrofolate reductase and trimethoprim resistance gene found in a groundwater sample at the Horonobe Underground Research laboratory in Japan in 2017, in a Betaproteobacteria sequence. PMID:28350393 dfrB11 ampR is a regulatory gene that plays an essential role in regulating antibiotic resistance in P. aeruginosa. Mutation in ampR leads to its loss of control over blaPDC-16, allowing overexpression of blaPDC-16 and further resistance to aztreonam. Paer_ampR_ATM antibiotic_resistance ARO:3007491 Pseudomonas aeruginosa ampR with mutation conferring resistance to aztreonam ampR is a regulatory gene that plays an essential role in regulating antibiotic resistance in P. aeruginosa. Mutation in ampR leads to its loss of control over blaPDC-16, allowing overexpression of blaPDC-16 and further resistance to aztreonam. PMID:37070974 Paer_ampR_ATM A novel tetA-type efflux pump. tet(62) antibiotic_resistance ARO:3007492 tet(62) A novel tetA-type efflux pump. PMID:33515651 tet(62) A tetracycline efflux MFS Transporter from Staphylococcus aureus. tet(63) antibiotic_resistance ARO:3007493 tet(63) A tetracycline efflux MFS Transporter from Staphylococcus aureus. PMID:33247717 tet(63) A tetracycline efflux MFS Transporter from Burkholderia ubonensis. tet(64) antibiotic_resistance ARO:3007494 tet(64) A tetracycline efflux MFS Transporter from Burkholderia ubonensis. PMID:33318011 tet(64) Azoles are a group of antibiotics, particularly antifungals, that target the cytochrome P450 enzyme sterol 14alpha-demethylase, which converts lanosterol to ergosterol. They are typically fungistatic in yeasts and fungicidal in molds. The two main groups of azoles are imidazoles and triazoles. antibiotic_resistance ARO:3007495 azole antibiotic Azoles are a group of antibiotics, particularly antifungals, that target the cytochrome P450 enzyme sterol 14alpha-demethylase, which converts lanosterol to ergosterol. They are typically fungistatic in yeasts and fungicidal in molds. The two main groups of azoles are imidazoles and triazoles. PMID:32906036 Echinocandins are a group of antibiotics, particularly antifungals, that target the target glucan synthase, an enzyme involved in the cell wall biosynthesis of fungi. They typically induce adaptive mechanisms that promote resistance such as heat shock protein 90, cell wall integrity pathway, high osmolarity glycerol pathway, and chitin biosynthesis. The three main echinocandins are caspofungin, micafungin and anidulafungin. antibiotic_resistance ARO:3007496 echinocandin antibiotic Echinocandins are a group of antibiotics, particularly antifungals, that target the target glucan synthase, an enzyme involved in the cell wall biosynthesis of fungi. They typically induce adaptive mechanisms that promote resistance such as heat shock protein 90, cell wall integrity pathway, high osmolarity glycerol pathway, and chitin biosynthesis. The three main echinocandins are caspofungin, micafungin and anidulafungin. PMID:4613708 Polyenes are a group of antibiotics, particularly antifungals, that bind ergosterol, a fungal-specific sterol in the plasma membrane of fungi, causing the efflux of potassium and cell death. They were discovered in the 1930s by Richard Kuhn. They are primarily used for therapy for invasive fungal infections like invasive aspergillosis, cryptococcosis blastomycosis, etc. The two main polyenes are amphotericin B and nystatin. antibiotic_resistance ARO:3007497 polyene antibiotic Polyenes are a group of antibiotics, particularly antifungals, that bind ergosterol, a fungal-specific sterol in the plasma membrane of fungi, causing the efflux of potassium and cell death. They were discovered in the 1930s by Richard Kuhn. They are primarily used for therapy for invasive fungal infections like invasive aspergillosis, cryptococcosis blastomycosis, etc. The two main polyenes are amphotericin B and nystatin. PMID:33261213 Allylamines are a group of antibiotics, particularly antifungals, that act as squalene epoxidase and ergosterol inhibitors. They have broad-spectrum activity against pathogenic fungi, especially dermatophytes. The two main allylamines are naftifine and terbinafine. antibiotic_resistance ARO:3007498 allylamine antibiotic Allylamines are a group of antibiotics, particularly antifungals, that act as squalene epoxidase and ergosterol inhibitors. They have broad-spectrum activity against pathogenic fungi, especially dermatophytes. The two main allylamines are naftifine and terbinafine. PMID:1822408 PMID:2229523 Triazoles are a group of antibiotics, particularly antifungals, derived from azoles. Triazoles include fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole. antibiotic_resistance ARO:3007499 triazole antibiotic Triazoles are a group of antibiotics, particularly antifungals, derived from azoles. Triazoles include fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole. PMID:35547394 Imidazoles are a group of antibiotics, particularly antifungals, derived from azoles. Imidazoles include imidazole derivatives clotrimazole, ketoconazole, miconazole, econazole and oxiconazole. antibiotic_resistance ARO:3007500 imidazole antibiotic Imidazoles are a group of antibiotics, particularly antifungals, derived from azoles. Imidazoles include imidazole derivatives clotrimazole, ketoconazole, miconazole, econazole and oxiconazole. PMID:18366001 PMID:7003674 Caspofungin is an antibiotic, particularly antifungal, derived from echinocandins. It has a wide range of activity against fungi and yeasts. pubchem.compound:3035406 antibiotic_resistance ARO:3007501 caspofungin Caspofungin is an antibiotic, particularly antifungal, derived from echinocandins. It has a wide range of activity against fungi and yeasts. PMID:11465873 Micafungin is an antibiotic, particularly antifungal, derived from echinocandins. It was discovered at Fujisawa Pharmaceutical Co., Ltd. It is active against most Candida species. pubchem.compound:477468 antibiotic_resistance ARO:3007502 micafungin Micafungin is an antibiotic, particularly antifungal, derived from echinocandins. It was discovered at Fujisawa Pharmaceutical Co., Ltd. It is active against most Candida species. PMID:18424132 Anidulafungin is an antibiotic, particularly antifungal, derived from echinocandins. It exhibits strong antifungal action against a variety of Candida spp. and Aspergillus spp., including those that are resistant to amphotericin B and triazole. pubchem.compound:166548 antibiotic_resistance ARO:3007503 anidulafungin Anidulafungin is an antibiotic, particularly antifungal, derived from echinocandins. It exhibits strong antifungal action against a variety of Candida spp. and Aspergillus spp., including those that are resistant to amphotericin B and triazole. PMID:15456342 Amphotericin B is an antibiotic, particularly antifungal, derived from polyene. It exhibits strong antifungal action against a variety of fungi species and is typically considered the gold standard of antifungals. pubchem.compound:5280965 antibiotic_resistance ARO:3007504 amphotericin B Amphotericin B is an antibiotic, particularly antifungal, derived from polyene. It exhibits strong antifungal action against a variety of fungi species and is typically considered the gold standard of antifungals. PMID:33523419 Nystatin is an antibiotic, particularly antifungal, derived from polyene. Nystatin is fungistatic in vitro against Candida albicans and certain other yeast-like fungi. pubchem.compound:6433272 antibiotic_resistance ARO:3007505 nystatin Nystatin is an antibiotic, particularly antifungal, derived from polyene. Nystatin is fungistatic in vitro against Candida albicans and certain other yeast-like fungi. PMID:4919155 Naftifine is an antibiotic, particularly antifungal, derived from Allylamine. It was discovered in 19742 at the Sandoz Research Institute in Vienna, Austria. Naftifine is fungicidal against a broad spectrum of dermatophyte fungi and provides good against Candida and Aspergillus species. pubchem.compound:47641 antibiotic_resistance ARO:3007506 naftifine Naftifine is an antibiotic, particularly antifungal, derived from Allylamine. It was discovered in 19742 at the Sandoz Research Institute in Vienna, Austria. Naftifine is fungicidal against a broad spectrum of dermatophyte fungi and provides good against Candida and Aspergillus species. PMID:1723367 PMID:18346400 Terbinafine is an antibiotic, particularly antifungal, derived from allylamine. Terbinafine is active against a broad range of fungi and yeast. It was discovered in 1983. pubchem.compound:1549008 antibiotic_resistance ARO:3007507 terbinafine Terbinafine is an antibiotic, particularly antifungal, derived from allylamine. Terbinafine is active against a broad range of fungi and yeast. It was discovered in 1983. PMID:1372222 Fluconazole is a type of triazole antibiotic, particularly antifungal. It is used for the treatment of superficial and systemic fungal infections. pubchem.compound:3365 antibiotic_resistance ARO:3007508 fluconazole Fluconazole is a type of triazole antibiotic, particularly antifungal. It is used for the treatment of superficial and systemic fungal infections. PMID:10830059 PMID:8448970 AcrA is a subunit of the AcrAB multidrug efflux system found in Shigella flexneri, which is encoded by the acrRAB operon. Sfle_acrA antibiotic_resistance ARO:3007509 Shigella flexneri acrA AcrA is a subunit of the AcrAB multidrug efflux system found in Shigella flexneri, which is encoded by the acrRAB operon. PMID:19035770 Sfle_acrA Itraconazole is a type of triazole antibiotic, particularly antifungal. It has broad spectrum activity against Candida and Malassezia species and Dermatophytes. pubchem.compound:55283 antibiotic_resistance ARO:3007511 itraconazole Itraconazole is a type of triazole antibiotic, particularly antifungal. It has broad spectrum activity against Candida and Malassezia species and Dermatophytes. PMID:2561187 Voriconazole is a type of triazole antibiotic, particularly antifungal. It is used for the treatment of invasive aspergillosis, candidaemia, and infections caused by Candida spp. pubchem.compound:71616 antibiotic_resistance ARO:3007512 voriconazole Voriconazole is a type of triazole antibiotic, particularly antifungal. It is used for the treatment of invasive aspergillosis, candidaemia, and infections caused by Candida spp. PMID:16278744 Posaconazole is a type of triazole antibiotic, particularly antifungal. It has broad spectrum activity against Candida albicans and Aspergillus fumigatus. pubchem.compound:468595 antibiotic_resistance ARO:3007513 posaconazole Posaconazole is a type of triazole antibiotic, particularly antifungal. It has broad spectrum activity against Candida albicans and Aspergillus fumigatus. PMID:10898669 Isavuconazole is a type of triazole antibiotic, particularly antifungal. It has activity against yeasts, dimorphic fungi, and molds. pubchem.compound:6918485 antibiotic_resistance ARO:3007514 isavuconazole Isavuconazole is a type of triazole antibiotic, particularly antifungal. It has activity against yeasts, dimorphic fungi, and molds. PMID:16284102 ANT(9)-Ic encodes an intrinsic, chromosomal aminoglycoside nucleotidyltransferase in Brucella intermedia. ANT(9)-Ic antibiotic_resistance ARO:3007515 ANT(9)-Ic ANT(9)-Ic encodes an intrinsic, chromosomal aminoglycoside nucleotidyltransferase in Brucella intermedia. PMID:37039640 ANT(9)-Ic Clotrimazole is a type of imidazole antibiotic, particularly antifungal. It is mostly used for the treatment of tinea pedis, vulvovaginal and oropharyngeal candidiasis. It has broad activity against Candida albicans and other fungal infections. pubchem.compound:2812 antibiotic_resistance ARO:3007516 clotrimazole Clotrimazole is a type of imidazole antibiotic, particularly antifungal. It is mostly used for the treatment of tinea pedis, vulvovaginal and oropharyngeal candidiasis. It has broad activity against Candida albicans and other fungal infections. PMID:4677595 PMID:5579860 Ketoconazole is a type of imidazole antibiotic, particularly antifungal. It was one of the first available oral broad-spectrum antifungals for the treatment of systemic and superficial mycoses. pubchem.compound:456201 antibiotic_resistance ARO:3007517 ketoconazole Ketoconazole is a type of imidazole antibiotic, particularly antifungal. It was one of the first available oral broad-spectrum antifungals for the treatment of systemic and superficial mycoses. PMID:6276122 PMID:707893 Miconazole is a type of imidazole antibiotic, particularly antifungal. It is used to treat oral and vaginal yeast infections, as well as mucosal thrush. pubchem.compound:4189 antibiotic_resistance ARO:3007518 miconazole Miconazole is a type of imidazole antibiotic, particularly antifungal. It is used to treat oral and vaginal yeast infections, as well as mucosal thrush. PMID:4563141 PMID:4919243 Econazole is a type of imidazole antibiotic, particularly antifungal. It is often used to treat tinea cruris, tinea pedis, and tinea corporis. pubchem.compound:3198 antibiotic_resistance ARO:3007519 econazole Econazole is a type of imidazole antibiotic, particularly antifungal. It is often used to treat tinea cruris, tinea pedis, and tinea corporis. PMID:1173036 PMID:4417140 Oxiconazole is a type of imidazole antibiotic, particularly antifungal. It is primarily used to treat tinea pedis, tinea cruris, tinea corporis, and tinea versicolor. pubchem.compound:5353853 antibiotic_resistance ARO:3007520 oxiconazole Oxiconazole is a type of imidazole antibiotic, particularly antifungal. It is primarily used to treat tinea pedis, tinea cruris, tinea corporis, and tinea versicolor. PMID:583212 PMID:7037014 Flumequine is a first generation fluoroquinolone antibiotic. It is used primarily for the treatment of enteric infections in domestic species. It has been removed from clinical use and is no longer being marketed. pubchem.compound:3374 antibiotic_resistance ARO:3007521 flumequine Flumequine is a first generation fluoroquinolone antibiotic. It is used primarily for the treatment of enteric infections in domestic species. It has been removed from clinical use and is no longer being marketed. PMID:34729090 Fungal cytochrome P450 enzymes which include mutations or other modifications to confer resistance to antifungal drug compounds. antibiotic_resistance ARO:3007522 antifungal-resistant cytochrome P450 enzyme Fungal cytochrome P450 enzymes which include mutations or other modifications to confer resistance to antifungal drug compounds. PMID:28176517 Fungal cytochrome P450 enzymes which include mutations to confer resistance to triazole-class antibiotics. antibiotic_resistance ARO:3007523 triazole-resistant fungal cytochrome P450 enzyme Fungal cytochrome P450 enzymes which include mutations to confer resistance to triazole-class antibiotics. PMID:28176517 ERG11 is a cytochrome P450 enzyme in Candida spp. Mutations in ERG11 have been shown to confer resistance to azole antibiotics including fluconazole and itraconazole. antibiotic_resistance ARO:3007524 Candida spp. ERG11 with mutations conferring resistance to azole antibiotics ERG11 is a cytochrome P450 enzyme in Candida spp. Mutations in ERG11 have been shown to confer resistance to azole antibiotics including fluconazole and itraconazole. PMID:28176517 PMID:35163552 Norvancomycin differs from vancomycin by a single methyl group and is typically used to treat methicillin-resistant Staphylococcus aureus (MRSA) ventriculitis in patients. pubchem.compound:10419027 antibiotic_resistance ARO:3007525 norvancomycin Norvancomycin differs from vancomycin by a single methyl group and is typically used to treat methicillin-resistant Staphylococcus aureus (MRSA) ventriculitis in patients. PMID:36823383 Amino acid substitutions in ribosomal protein S5, the product of the rpsE gene, is associated with resistance to spectinomycin (SpcR). This protein is located on the 30S subunit and interacts with 16S rRNA and other proteins. Ribosomal protein S5 antibiotic_resistance ARO:3007526 spectinomycin resistant rpsE Amino acid substitutions in ribosomal protein S5, rpsE, is associated with resistance to spectinomycin (SpcR). Bsub_rpsE_SPT antibiotic_resistance ARO:3007527 Bacillus subtilis rpsE mutations conferring resistance to spectinomycin Amino acid substitutions in ribosomal protein S5, rpsE, is associated with resistance to spectinomycin (SpcR). PMID:34339280 Bsub_rpsE_SPT Gallic acid was found to enhance sulfonamides against multidrug-resistant S. suis. Gallic acid effectively disrupts the integrity and function of the cytoplasmic membrane by dissipating the proton motive force of bacteria. It regulates the expression of dihydrofolate reductase, which then inhibits tetrahydrofolate synthesis. As a result of polypharmacology, gallic acid can fully restore sulfadiazine sodium activity in the animal infection model without any drug resistances. pubchem.compound:370 antibiotic_resistance ARO:3007528 gallic acid Gallic acid was found to enhance sulfonamides against multidrug-resistant S. suis. Gallic acid effectively disrupts the integrity and function of the cytoplasmic membrane by dissipating the proton motive force of bacteria. It regulates the expression of dihydrofolate reductase, which then inhibits tetrahydrofolate synthesis. As a result of polypharmacology, gallic acid can fully restore sulfadiazine sodium activity in the animal infection model without any drug resistances. PMID:37125728 Pivmecillinam, the oral prodrug of the antimicrobial active agent mecillinam, is a bona fide agent for uncomplicated lower urinary tract infections (UTIs), because of its selectivity and effect against several species of Enterobacteriaceae. pubchem.compound:115163 amdinocillin pivoxil antibiotic_resistance ARO:3007529 pivmecillinam Pivmecillinam, the oral prodrug of the antimicrobial active agent mecillinam, is a bona fide agent for uncomplicated lower urinary tract infections (UTIs), because of its selectivity and effect against several species of Enterobacteriaceae. PMID:31067667 PBP2x is a penicillin-binding protein and beta-lactam resistance enzyme. Mutations can cause resistance to some beta-lactam antibiotics. antibiotic_resistance ARO:3007530 Streptococcus pyogenes PBP2x with mutation conferring resistance to beta-lactam antibiotics PBP2x is a penicillin-binding protein and beta-lactam resistance enzyme. Mutations can cause resistance to some beta-lactam antibiotics. Spyo_PBP2x_BLA antibiotic_resistance ARO:3007531 Streptococcus pyogenes PBP2x conferring resistance to beta-lactam antibiotics PBP2x is a penicillin-binding protein and beta-lactam resistance enzyme. Mutations can cause resistance to some beta-lactam antibiotics. PMID:31630171 PMID:36374114 Spyo_PBP2x_BLA Proflavine, also called proflavin and diaminoacridine, is an acriflavine derivative, a disinfectant bacteriostatic against many gram-positive bacteria. pubchem.compound:7099 diaminoacridine proflavin antibiotic_resistance ARO:3007532 proflavine Proflavine, also called proflavin and diaminoacridine, is an acriflavine derivative, a disinfectant bacteriostatic against many gram-positive bacteria. PMID:36240541 An MCR-4-type colistin resistance gene variant. MCR-4.7 antibiotic_resistance ARO:3007533 MCR-4.7 An MCR-4-type colistin resistance gene variant. PMID:37171842 MCR-4.7 Arsinothricin is a natural product synthesized by the rhizosphere bacterium Burkholderia gladioli GSRB05 and is a broad-spectrum antibiotic effective against human pathogens such as carbapenem-resistant Enterobacter cloacae. It is a non-proteogenic amino acid and glutamate mimetic that inhibits bacterial glutamine synthetase. antibiotic_resistance ARO:3007534 arsinothricin Arsinothricin is a natural product synthesized by the rhizosphere bacterium Burkholderia gladioli GSRB05 and is a broad-spectrum antibiotic effective against human pathogens such as carbapenem-resistant Enterobacter cloacae. It is a non-proteogenic amino acid and glutamate mimetic that inhibits bacterial glutamine synthetase. PMID:36785875 Pretomanid is an antibiotic medication used for the treatment of multi-drug-resistant tuberculosis affecting the lungs. pubchem.compound:456199 antibiotic_resistance ARO:3007535 pretomanid Pretomanid is an antibiotic medication used for the treatment of multi-drug-resistant tuberculosis affecting the lungs. PMID:36409105 Point mutation in M. tuberculosis rrnS conferring resistance to amikacin antibiotic. Mtub_16rrnS_AMK antibiotic_resistance ARO:3007536 Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to amikacin Point mutation in M. tuberculosis rrnS conferring resistance to amikacin antibiotic. PMID:37224060 Mtub_16rrnS_AMK Point mutation in M. tuberculosis rrnS conferring resistance to kanamycin antibiotic. Mtub_16rrnS_KAN antibiotic_resistance ARO:3007537 Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to kanamycin Point mutation in M. tuberculosis rrnS conferring resistance to kanamycin antibiotic. PMID:37224060 Mtub_16rrnS_KAN A cholic acid derivative of the traditional Chinese medicine (TCM) Tanreqing (TRQ), synergizes with amikacin against Staphylococcus aureus in vitro, and this synergistic killing was effective against diverse methicillin-resistant S. aureus (MRSA) variants. Mechanistically, chenodeoxycholic acid increases the uptake of aminoglycosides in a proton motive force-dependent manner by dissipating the chemical potential and potentiates reactive oxygen species (ROS) generation by inhibiting superoxide dismutase activity. pubchem.compound:10133 antibiotic_resistance ARO:3007538 chenodeoxycholic acid A cholic acid derivative of the traditional Chinese medicine (TCM) Tanreqing (TRQ), synergizes with amikacin against Staphylococcus aureus in vitro, and this synergistic killing was effective against diverse methicillin-resistant S. aureus (MRSA) variants. Mechanistically, chenodeoxycholic acid increases the uptake of aminoglycosides in a proton motive force-dependent manner by dissipating the chemical potential and potentiates reactive oxygen species (ROS) generation by inhibiting superoxide dismutase activity. PMID:36625660 APH(9)-Ic is a chromosomal-encoded aminoglycoside phosphotransferase in S. maltophilia. APH(9)-Ic antibiotic_resistance ARO:3007539 APH(9)-Ic APH(9)-Ic is a chromosomal-encoded aminoglycoside phosphotransferase in S. maltophilia. PMID:36699730 APH(9)-Ic Cyclomarins are cyclic heptapeptides containing four unusual amino acids. Cyclomarins target two different targets: Clp C1, a subunit of the caseinolytic protease of Mycobacterium tuberculosis (MTB), and PfAp3Ase of Plasmodium falciparum. Therefore, cyclomarins are interesting lead structures for the development of drugs against tuberculosis and malaria. antibiotic_resistance ARO:3007540 cyclomarin antibiotics Cyclomarins are cyclic heptapeptides containing four unusual amino acids. Cyclomarins target two different targets: Clp C1, a subunit of the caseinolytic protease of Mycobacterium tuberculosis (MTB), and PfAp3Ase of Plasmodium falciparum. Therefore, cyclomarins are interesting lead structures for the development of drugs against tuberculosis and malaria. PMID:27241518 PMID:36748577 Cyclomarin A was found to be bacteriocidal against bacteria replicating in culture broth and in human-derived macrophages and a series of multidrug resistant clinical isolates. It was identified as a potent antitubercular compound in a natural product whole cell screen. Importantly it kills both growing and dormant, non-replicating mycobacteria. pubchem.compound:10772429 antibiotic_resistance ARO:3007541 cyclomarin A Cyclomarin A was found to be bacteriocidal against bacteria replicating in culture broth and in human-derived macrophages and a series of multidrug resistant clinical isolates. It was identified as a potent antitubercular compound in a natural product whole cell screen. Importantly it kills both growing and dormant, non-replicating mycobacteria. PMID:27241518 PMID:36748577 Cyclomarin B is a cyclomarin antibiotic. pubchem.compound:21593897 antibiotic_resistance ARO:3007542 cyclomarin B Cyclomarin B is a cyclomarin antibiotic. PMID:27241518 Cyclomarin C is a cyclomarin antibiotic. pubchem.compound:11205419 antibiotic_resistance ARO:3007543 cyclomarin C Cyclomarin C is a cyclomarin antibiotic. PMID:27241518 Sequence analysis of the gyrA gene showed that resistance of E. rhusiopathiae strains to enrofloxacin is due to a mutation at position 257. Erhu_gyrA_ENR antibiotic_resistance ARO:3007544 Erysipelothrix rhusiopathiae gyrA with mutation conferring resistance to enrofloxacin Sequence analysis of the gyrA gene showed that resistance of E. rhusiopathiae strains to enrofloxacin is due to a mutation at position 257. PMID:36986331 Erhu_gyrA_ENR Fungal beta-1,3-D-glucan synthase enzymes which include mutations to confer resistance to antifungal drug compounds. antibiotic_resistance ARO:3007545 antifungal-resistant beta-1,3-D-glucan synthase Fungal beta-1,3-D-glucan synthase enzymes which include mutations to confer resistance to antifungal drug compounds. PMID:19546367 Fungal beta-1,3-D-glucan synthases which include mutations to confer resistance to echinocandin-class antibiotics. antibiotic_resistance ARO:3007546 echinocandin antibiotic-resistant beta-1,3-D-glucan synthase Fungal beta-1,3-D-glucan synthases which include mutations to confer resistance to echinocandin-class antibiotics. PMID:19546367 Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. pubchem.compound:3085092 antibiotic_resistance ARO:3007547 salinomycin Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. PMID:37276926 Glucan synthase FKS2 is involved in the production of the fungal cell wall by the synthesis of the core component beta-1,3-glucan in Candida spp. Mutations in FKS2 have been shown to confer resistance to echinocandin antibiotic micafungin. antibiotic_resistance ARO:3007548 Candida spp. FKS2 with mutations conferring resistance to echinocandin antibiotics Glucan synthase FKS2 is involved in the production of the fungal cell wall by the synthesis of the core component beta-1,3-glucan in Candida spp. Mutations in FKS2 have been shown to confer resistance to echinocandin antibiotic micafungin. PMID:19546367 Fungal sterol regulatory element binding proteins are transcription factors that modulate antibiotic-susceptible genes. Mutations in these proteins confer resistance to antifungal drug compounds through differential gene regulation. antibiotic_resistance ARO:3007549 antibiotic resistant ergosterol biosynthesis pathway transcription factor Fungal sterol regulatory element binding proteins are transcription factors that modulate antibiotic-susceptible genes. Mutations in these proteins confer resistance to antifungal drug compounds through differential gene regulation. PMID:18487346 Upc2 is a sterol synthesis regulatory element binding protein in Candida spp. Mutations in Upc2 have been shown to confer resistance to azole antibiotics including fluconazole by upregulating ERG11 expression. antibiotic_resistance ARO:3007551 Candida spp. Upc2 with mutations conferring resistance to azole antibiotics Upc2 is a sterol synthesis regulatory element binding protein in Candida spp. Mutations in Upc2 have been shown to confer resistance to azole antibiotics including fluconazole by upregulating ERG11 expression. PMID:18487346 Pleiotropic Drug Resistance factors (PDR) are transcription factors in fungi that regulate the expression of genes encoding for efflux pumps causing multidrug resistance. antibiotic_resistance ARO:3007552 pleiotropic drug resistance transcription factors Pleiotropic Drug Resistance factors (PDR) are transcription factors in fungi that regulate the expression of genes encoding for efflux pumps causing multidrug resistance. PMID:15388433 PMID:7614555 PMID:9043118 CDR1 is a pleiotropic drug resistance gene encoding ABC transporters that contributes to multidrug antifungal resistance in Candida spp. antibiotic_resistance ARO:3007553 Candida spp. CDR1 CDR1 is a pleiotropic drug resistance gene encoding ABC transporters that contributes to multidrug antifungal resistance in Candida spp. PMID:7614555 CDR2 is a Pleiotropic drug resistance gene encoding ABC transporters that contributes to multidrug antifungal resistance in Candida spp. antibiotic_resistance ARO:3007554 Candida spp. CDR2 CDR2 is a Pleiotropic drug resistance gene encoding ABC transporters that contributes to multidrug antifungal resistance in Candida spp. PMID:9043118 Zn2Cys6 is a transcription factor family that includes mutations to confer resistance to azole-class antibiotics. antibiotic_resistance ARO:3007555 Zn2Cys6 transcription factors Zn2Cys6 is a transcription factor family that includes mutations to confer resistance to azole-class antibiotics. PMID:16452151 Fungal uracil phosphoribosyltransferases which include mutations to confer resistance to 5-flucytosine antibiotic. antibiotic_resistance ARO:3007556 fungal uracil phosphoribosyltransferase Fungal uracil phosphoribosyltransferases which include mutations to confer resistance to 5-flucytosine antibiotic. PMID:15504867 FUR1 is a fungal uracil phosphoribosyltransferase in Candida spp. It encodes the UPRT protein, also known as uracil pyrophosphorylase, which is a key regulating enzyme in pyrimidine salvage. Mutations in FUR1 have been shown to confer resistance to 5-flucytosine. antibiotic_resistance ARO:3007557 Candida spp. FUR1 with mutations conferring resistance to 5-flucytosine FUR1 is a fungal uracil phosphoribosyltransferase in Candida spp. It encodes the UPRT protein, also known as uracil pyrophosphorylase, which is a key regulating enzyme in pyrimidine salvage. Mutations in FUR1 have been shown to confer resistance to 5-flucytosine. PMID:15504867 5-Flucytosine is an antibiotic, particularly antifungal. It inhibits fungal RNA and DNA synthesis by changing the amino-acylation of tRNA, causing the amino acid pool to be altered and protein synthesis to be inhibited. pubchem.compound:3366 antibiotic_resistance ARO:3007558 5-flucytosine 5-Flucytosine is an antibiotic, particularly antifungal. It inhibits fungal RNA and DNA synthesis by changing the amino-acylation of tRNA, causing the amino acid pool to be altered and protein synthesis to be inhibited. PMID:37051439 FUR1 is a fungal uracil phosphoribosyltransferase in Saccharomyces spp. It encodes the UPRT protein, also known as uracil pyrophosphorylase, which is a key regulating enzyme in pyrimidine salvage. Mutations in FUR1 have been shown to confer resistance to 5-flucytosine. antibiotic_resistance ARO:3007559 Saccharomyces spp. FUR1 with mutations conferring resistance to 5-flucytosine FUR1 is a fungal uracil phosphoribosyltransferase in Saccharomyces spp. It encodes the UPRT protein, also known as uracil pyrophosphorylase, which is a key regulating enzyme in pyrimidine salvage. Mutations in FUR1 have been shown to confer resistance to 5-flucytosine. PMID:2189783 Any pyrimidine antifungal agent that has been used for the treatment of fungal infections in humans or animals. antibiotic_resistance ARO:3007560 pyrimidine antifungal drug The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis. OXA-1038 antibiotic_resistance ARO:3007561 OXA-1038 The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis. PMID:37317299 OXA-1038 The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis. OXA-1039 antibiotic_resistance ARO:3007562 OXA-1039 The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis. PMID:37317299 OXA-1039 TAC1 is a Zn2Cys6 transcription factor that transcriptionally activates efflux units CDR1 and CDR2. Mutations in TAC1 upregulate CDR1 and CDR2 causing increased resistance. antibiotic_resistance ARO:3007563 Candida spp. TAC1 with mutations conferring resistance to azole antibiotics TAC1 is a Zn2Cys6 transcription factor that transcriptionally activates efflux units CDR1 and CDR2. Mutations in TAC1 upregulate CDR1 and CDR2 causing increased resistance. PMID:16452151 The pH-dependant transcription factors regulate the expression of antifungal resistance-conferring genes based on the pH of the environment. antibiotic_resistance ARO:3007564 pH-responsive transcription factors The pH-dependant transcription factors regulate the expression of antifungal resistance-conferring genes based on the pH of the environment. PMID:29610197 Aspergillus spp. cyp51A is a fungal cytochrome P450 enzyme with mutations in the gene causing triazole resistance. antibiotic_resistance ARO:3007565 Aspergillus spp. cyp51A with mutations conferring resistance to triazoles antibiotics Aspergillus spp. cyp51A is a fungal cytochrome P450 enzyme with mutations in the gene causing triazole resistance. PMID:12604551 PMID:15215142 Cryptococcus spp. AFR1 gene is an ABC transporter gene that contributes to antifungal resistance through antibiotic efflux. antibiotic_resistance ARO:3007566 Cryptococcus spp. AFR1 Cryptococcus spp. AFR1 gene is an ABC transporter gene that contributes to antifungal resistance through antibiotic efflux. PMID:12519188 UDP-glucuronic acid decarboxylase catalyzes the decarboxylation of UDP-glucuronic acid. Accumulation of UDP-glucuronic acid mediates resistance to 5-flucytosine. antibiotic_resistance ARO:3007567 UDP-glucuronic acid decarboxylase UDP-glucuronic acid decarboxylase catalyzes the decarboxylation of UDP-glucuronic acid. Accumulation of UDP-glucuronic acid mediates resistance to 5-flucytosine. PMID:31913284 PMID:34103502 UXS1 is a UDP-glucuronic acid decarboxylase. Deletion of UXS1 confers resistance to 5-flucytosine by accumulation of UDP-glucoronic acid, thereby suppressing the cellular toxicity of 5-flucytosine. antibiotic_resistance ARO:3007568 Cryptococcus spp. UXS1 conferring resistance to 5-flucytosine via absence UXS1 is a UDP-glucuronic acid decarboxylase. Deletion of UXS1 confers resistance to 5-flucytosine by accumulation of UDP-glucoronic acid, thereby suppressing the cellular toxicity of 5-flucytosine. PMID:31913284 PMID:34103502 Specific automated system of analysis for determining antimicrobial susceptibility developed by Giles Scientific. antibiotic_resistance ARO:3007569 BIOMIC Microbiology System Mycaminosyltylonolide is a tylosin derivative with promising anti- P. aeruginosa activity, especially when combined with other antibiotics such as polymixin B. pubchem.compound:6437420 5-O-mycaminosyltylonolide antibiotic_resistance ARO:3007570 Mycaminosyltylonolide Mycaminosyltylonolide is a tylosin derivative with promising anti- P. aeruginosa activity, especially when combined with other antibiotics such as polymixin B. PMID:37208456 Cefquinome is a fourth-generation cephalosporin with pharmacological and antibacterial properties valuable in the treatment of coliform mastitis and other infections. pubchem.compound:5464355 antibiotic_resistance ARO:3007571 cefquinome Cefquinome is a fourth-generation cephalosporin with pharmacological and antibacterial properties valuable in the treatment of coliform mastitis and other infections. PMID:37280708 Cinnamaldehyde was found to enhance the antibacterial activity of ceftriaxone sodium against MDR Salmonella in vitro by significantly reducing the expression of extended-spectrum beta-lactamase, inhibiting the development of drug resistance under ceftriaxone selective pressure in vitro, damaging the cell membrane, and affecting its basic metabolism. pubchem.compound:637511 antibiotic_resistance ARO:3007572 cinnamaldehyde Cinnamaldehyde was found to enhance the antibacterial activity of ceftriaxone sodium against MDR Salmonella in vitro by significantly reducing the expression of extended-spectrum beta-lactamase, inhibiting the development of drug resistance under ceftriaxone selective pressure in vitro, damaging the cell membrane, and affecting its basic metabolism. PMID:37298240 Fasamycins and congeners are a class of rare aromatic polyketides possessing a partially reduced 1-phenyltetracene pentacyclic core. antibiotic_resistance ARO:3007573 fasamycin Fasamycins and congeners are a class of rare aromatic polyketides possessing a partially reduced 1-phenyltetracene pentacyclic core. PMID:37327570 The formicamycins are promising antibiotics first identified in Streptomyces formicae KY5, which produces the compounds at low levels. antibiotic_resistance ARO:3007574 formicamycin The formicamycins are promising antibiotics first identified in Streptomyces formicae KY5, which produces the compounds at low levels. PMID:33440167 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. pubchem.compound:57404528 antibiotic_resistance ARO:3007575 fasamcyin A Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. pubchem.compound:57404257 antibiotic_resistance ARO:3007576 fasamcyin B Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. pubchem.compound:156016388 antibiotic_resistance ARO:3007577 fasamcyin G Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. pubchem.compound:156017923 antibiotic_resistance ARO:3007578 fasamcyin H Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. pubchem.compound:156012442 antibiotic_resistance ARO:3007579 fasamcyin I Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. pubchem.compound:156017733 antibiotic_resistance ARO:3007580 fasamcyin J Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. pubchem.compound:156581097 antibiotic_resistance ARO:3007581 fasamcyin K Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684581 antibiotic_resistance ARO:3007582 formicamycin A Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684582 antibiotic_resistance ARO:3007583 formicamycin B Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684583 antibiotic_resistance ARO:3007584 formicamycin C Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684585 antibiotic_resistance ARO:3007585 formicamycin E Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684593 antibiotic_resistance ARO:3007586 formicamycin M Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:156020171 antibiotic_resistance ARO:3007587 formicamycin O Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684592 antibiotic_resistance ARO:3007588 formicamycin L Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684586 antibiotic_resistance ARO:3007589 formicamycin F Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:156011794 antibiotic_resistance ARO:3007590 formicamycin P Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684587 antibiotic_resistance ARO:3007591 formicamycin G Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684584 antibiotic_resistance ARO:3007592 formicamycin D Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:156010277 antibiotic_resistance ARO:3007593 formicamycin N Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684588 antibiotic_resistance ARO:3007594 formicamycin H Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:156018422 antibiotic_resistance ARO:3007595 formicamycin Q Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684589 antibiotic_resistance ARO:3007596 formicamycin I Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684590 antibiotic_resistance ARO:3007597 formicamycin J Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. pubchem.compound:146684591 antibiotic_resistance ARO:3007598 formicamycin K Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Propolis has a significant synergistic effect in combination with ciprofloxacin, erythromycin, and gentamycin. It has a potent inhibitory activity toward the S. aureus (MRS USA300) pump system. pubchem.compound:11148893 antibiotic_resistance ARO:3007599 propolis Propolis has a significant synergistic effect in combination with ciprofloxacin, erythromycin, and gentamycin. It has a potent inhibitory activity toward the S. aureus (MRS USA300) pump system. PMID:36777436 The polyketide antibiotics cervimycins are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug-resistant staphylococci and vancomycin-resistant enterococci. antibiotic_resistance ARO:3007600 cervimycin The polyketide antibiotics cervimycins are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug-resistant staphylococci and vancomycin-resistant enterococci. PMID:36173303 Cervimycins are polyketide antibiotics. pubchem.compound:11557219 antibiotic_resistance ARO:3007601 cervimycin A Cervimycins are polyketide antibiotics. PMID:36173303 Cervimycins are polyketide antibiotics. pubchem.compound:11693822 antibiotic_resistance ARO:3007602 cervimycin B Cervimycins are polyketide antibiotics. PMID:36173303 Cervimycins are polyketide antibiotics. pubchem.compound:54687465 antibiotic_resistance ARO:3007603 cervimycin C Cervimycins are polyketide antibiotics. PMID:36173303 Cervimycins are polyketide antibiotics. pubchem.compound:54677926 antibiotic_resistance ARO:3007604 cervimycin D Cervimycins are polyketide antibiotics. PMID:36173303 Cervimycins are polyketide antibiotics. pubchem.compound:54726226 antibiotic_resistance ARO:3007605 cervimycin K1 Cervimycins are polyketide antibiotics. PMID:36173303 Cervimycins are polyketide antibiotics. pubchem.compound:54579611 antibiotic_resistance ARO:3007606 cervimycin K2 Cervimycins are polyketide antibiotics. PMID:36173303 Cervimycins are polyketide antibiotics. pubchem.compound:54726225 antibiotic_resistance ARO:3007607 cervimycin N Cervimycins are polyketide antibiotics. PMID:36173303 ERG11 is a cytochrome P450 enzyme in Candida species that is not functional when bound by azole antibiotics including fluconazole and itraconazole. However, high levels of ERG11 expression can overcome effective azole doses. antibiotic_resistance ARO:3007608 antibiotic susceptible ERG11 ERG11 is a cytochrome P450 enzyme in Candida species that is not functional when bound by azole antibiotics including fluconazole and itraconazole. However, high levels of ERG11 expression can overcome effective azole doses. PMID:18487346 PMID:35163552 Increased expression of an antibiotic target protein can overcome effective dose of an antibiotic, leading to reduced susceptibility. antibiotic_resistance ARO:3007609 antibiotic target overexpression Genes that directly or indirectly modulate azole resistance. antibiotic_resistance ARO:3007610 gene modulating azole resistance Sarafloxacin is used for treatment and control of bacterial infections in poultry caused by Escherichia coli and Salmonella spp. It was removed from the market by manufacturers in 2001. pubchem.compound:56208 antibiotic_resistance ARO:3007611 sarafloxacin Sarafloxacin is used for treatment and control of bacterial infections in poultry caused by Escherichia coli and Salmonella spp. It was removed from the market by manufacturers in 2001. PMID:37250042 Hinokitiol (beta-thujaplicin), a natural tropolone derivative found in the heartwood of cupressaceous plants, has been widely used in oral and skin care products as an antimicrobial agent, specifically to enhance tetracyclines against Staphylococcus aureus. pubchem.compound:3611 antibiotic_resistance ARO:3007612 hinokitiol Hinokitiol (beta-thujaplicin), a natural tropolone derivative found in the heartwood of cupressaceous plants, has been widely used in oral and skin care products as an antimicrobial agent, specifically to enhance tetracyclines against Staphylococcus aureus. PMID:36943047 The phenolic diterpene totarol had good antimicrobial activity against effluxing strains of Staphylococcus aureus. Totoral acts as a NorA efflux pump inhibitor as well as an antistaphylococcal antimicrobial agent. pubchem.compound:92783 antibiotic_resistance ARO:3007613 totoral The phenolic diterpene totarol had good antimicrobial activity against effluxing strains of Staphylococcus aureus. Totoral acts as a NorA efflux pump inhibitor as well as an antistaphylococcal antimicrobial agent. PMID:17664318 Resveratrol is a naturally occurring polyphenolic compound that is produced by many different plants, displays antioxidant properties, and protects macromolecules against damage by reactive oxygen species. ATP synthase inhibition with resveratrol can enhance the activity of aminoglycosides against S. aureus and potentially against other bacterial pathogens. pubchem.compound:445154 antibiotic_resistance ARO:3007614 resveratrol Resveratrol is a naturally occurring polyphenolic compound that is produced by many different plants, displays antioxidant properties, and protects macromolecules against damage by reactive oxygen species. ATP synthase inhibition with resveratrol can enhance the activity of aminoglycosides against S. aureus and potentially against other bacterial pathogens. PMID:29906565 Pyrrolomycins are protonophore antibiotics produced by Actinosporangium and Streptomyces. The mechanism of their antimicrobial activity consists in depolarization of bacterial membrane, leading to the suppression of bacterial bioenergetics through the uncoupling of oxidative phosphorylation. antibiotic_resistance ARO:3007615 pyrrolomycin antibiotic Pyrrolomycins are protonophore antibiotics produced by Actinosporangium and Streptomyces. The mechanism of their antimicrobial activity consists in depolarization of bacterial membrane, leading to the suppression of bacterial bioenergetics through the uncoupling of oxidative phosphorylation. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:133275 antibiotic_resistance ARO:3007616 pyrrolomycin A Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:133274 antibiotic_resistance ARO:3007617 pyrrolomycin B Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:133779 antibiotic_resistance ARO:3007618 pyrrolomycin C Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:133780 antibiotic_resistance ARO:3007619 pyrrolomycin D Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:5487782 antibiotic_resistance ARO:3007620 pyrrolomycin E Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:3086276 antibiotic_resistance ARO:3007621 pyrrolomycin F Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:181928 antibiotic_resistance ARO:3007622 pyrrolomycin F2a Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:102115511 antibiotic_resistance ARO:3007623 pyrrolomycin F2b Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:11360758 antibiotic_resistance ARO:3007624 pyrrolomycin G Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:11303705 antibiotic_resistance ARO:3007625 pyrrolomycin H Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:102115512 antibiotic_resistance ARO:3007626 pyrrolomycin F3 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:11772125 antibiotic_resistance ARO:3007627 pyrrolomycin I Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. pubchem.compound:11337778 antibiotic_resistance ARO:3007628 pyrrolomycin J Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 The cadasides are calcium-dependent cyclic acidic lipopeptide antibiotics that disrupt cell wall biosynthesis and show activity against multiple drug-resistant Gram-positive pathogens. antibiotic_resistance ARO:3007629 cadaside antibiotic The cadasides are calcium-dependent cyclic acidic lipopeptide antibiotics that disrupt cell wall biosynthesis and show activity against multiple drug-resistant Gram-positive pathogens. PMID:36168660 Cadasides are lipopeptides with antibiotic activity. pubchem.compound:146682091 antibiotic_resistance ARO:3007630 cadaside A Cadasides are lipopeptides with antibiotic activity. PMID:36168660 Cadasides are lipopeptides with antibiotic activity. pubchem.compound:146682092 antibiotic_resistance ARO:3007631 cadaside B Cadasides are lipopeptides with antibiotic activity. PMID:36168660 FRI-11 is a FRI-type carbapenem-hydrolyzing class A beta-lactamase. FRI-11 antibiotic_resistance ARO:3007632 FRI-11 FRI-11 is a FRI-type carbapenem-hydrolyzing class A beta-lactamase. PMID:36773190 FRI-11 KPC-125 is a KPC-type class A beta-lactamase. KPC-125 is a variant of KPC-3, differing by a D179A polymorphism within the omega-loop region. KPC-125 antibiotic_resistance ARO:3007633 KPC-125 KPC-125 is a KPC-type class A beta-lactamase. KPC-125 is a variant of KPC-3, differing by a D179A polymorphism within the omega-loop region. PMID:36112395 KPC-125 CAE beta-lactamases are a novel class A serine beta-lactamase family first isolated from Comamonas aquatica. antibiotic_resistance ARO:3007634 CAE beta-lactamase CAE beta-lactamases are a novel class A serine beta-lactamase family first isolated from Comamonas aquatica. PMID:36869066 CAE-1 is a CAE beta-lactamase and confers resistance to ampicillin, piperacillin, cefazolin, cefuroxime, and ceftriaxone, and elevates the MIC of ampicillin-sulbactam two-fold in Escherichia coli DH5alpha, suggesting that CAE-1 functions as a broad-spectrum beta-lactamase. CAE-1 antibiotic_resistance ARO:3007635 CAE-1 CAE-1 is a CAE beta-lactamase and confers resistance to ampicillin, piperacillin, cefazolin, cefuroxime, and ceftriaxone, and elevates the MIC of ampicillin-sulbactam two-fold in Escherichia coli DH5alpha, suggesting that CAE-1 functions as a broad-spectrum beta-lactamase. PMID:36869066 CAE-1 Iboxamycin is a fully synthetic lincosamide antibiotic. Like other lincosamides, it selectively targets the bacterial ribosome and prevents elongation of the peptide chain. Iboxamycin has been shown to be effective against bacterial strains otherwise resistant to licosamide antibiotics. pubchem.compound:156613433 antibiotic_resistance ARO:3007636 iboxamycin Iboxamycin is a fully synthetic lincosamide antibiotic. Like other lincosamides, it selectively targets the bacterial ribosome and prevents elongation of the peptide chain. Iboxamycin has been shown to be effective against bacterial strains otherwise resistant to licosamide antibiotics. PMID:34707295 CplR is an ABC-F ATPase ribosomal protection protein from Clostridioides difficile which confers resistance to pleuromutilins and lincosamides. Its resistance to these antibiotics increases in synergy with erythromcyin resistance methylases (e.g., ermB). cplR antibiotic_resistance ARO:3007637 Clostridioides difficile cplR CplR is an ABC-F ATPase ribosomal protection protein from Clostridioides difficile which confers resistance to pleuromutilins and lincosamides. Its resistance to these antibiotics increases in synergy with erythromcyin resistance methylases (e.g., ermB). PMID:36951104 cplR Hygromycin A is an antibiotic produced by Streptomyces hygroscopicus. It inhibits translation by binding to the peptidyl transferase center on the large ribosomal subunit. This prevents the binding of aminoacyl-tRNA to the A-site. Not to confused with Hygromycin B, which is structurally distinct. pubchem.compound:6433481 totomycin antibiotic_resistance ARO:3007638 hygromycin A Hygromycin A is an antibiotic produced by Streptomyces hygroscopicus. It inhibits translation by binding to the peptidyl transferase center on the large ribosomal subunit. This prevents the binding of aminoacyl-tRNA to the A-site. Not to confused with Hygromycin B, which is structurally distinct. PMID:26028538 A201A is a nucleoside antibiotic. It inhibits translation by binding to the peptidyl transferase center on the large ribosomal subunit. This prevents the binding of aminoacyl-tRNA to the A-site. pubchem.compound:6441582 antibiotic_resistance ARO:3007639 A201A A201A is a nucleoside antibiotic. It inhibits translation by binding to the peptidyl transferase center on the large ribosomal subunit. This prevents the binding of aminoacyl-tRNA to the A-site. PMID:26028538 PDR1 is a transcription factor that regulates the expression of several genes encoding ABC transporters, contributing to multidrug resistance. antibiotic_resistance ARO:3007640 Candida spp. pleiotropic drug resistance factor 1 PDR1 is a transcription factor that regulates the expression of several genes encoding ABC transporters, contributing to multidrug resistance. PMID:15388433 Fungal nucleobase transporters facilitate the movement of nucleobases across the fungal cell membrane. The absence confers resistance to antibiotics by preventing antibiotic entry into the cell. antibiotic_resistance ARO:3007641 fungal nucleobase transporters Fungal nucleobase transporters facilitate the movement of nucleobases across the fungal cell membrane. The absence confers resistance to antibiotics by preventing antibiotic entry into the cell. PMID:17784857 FcyB encodes for purine-cytosine permease in fungal cells. Downregulation or absence of fcyB confers resistance to antibiotics by preventing entry into the cell. antibiotic_resistance ARO:3007642 Aspergillus spp. fcyB conferring resistance to 5-flucytosine via reduced permeability FcyB encodes for purine-cytosine permease in fungal cells. Downregulation or absence of fcyB confers resistance to antibiotics by preventing entry into the cell. PMID:29610197 PacC is a pH-responsive transcription factor. It regulates the expression of antibiotic susceptible genes whose absence confers resistance to antibiotics. antibiotic_resistance ARO:3007643 Aspergillus spp. transcription factor pacC PacC is a pH-responsive transcription factor. It regulates the expression of antibiotic susceptible genes whose absence confers resistance to antibiotics. PMID:29610197 CplR is an ABC-F ATPase ribosomal protection protein from Clostridium perfringes which confers resistance to pleuromutilins and lincosamides. Cper_cplR antibiotic_resistance ARO:3007644 Clostridium perfringes cplR CplR is an ABC-F ATPase ribosomal protection protein from Clostridium perfringes which confers resistance to pleuromutilins and lincosamides. PMID:36951104 Cper_cplR CplR is an ABC-F ATPase ribosomal protection protein from Clostridium sporogenes which confers resistance to pleuromutilins and lincosamides. Cspo_cplR antibiotic_resistance ARO:3007645 Clostridium sporogenes cplR CplR is an ABC-F ATPase ribosomal protection protein from Clostridium sporogenes which confers resistance to pleuromutilins and lincosamides. PMID:36951104 Cspo_cplR vmlR2 is an ABC-F ATPase ribosomal protection protein from Neobacillus vireti (formerly known as Bacillus vireti). This representative of the ARE2 subfamily has an unusually long linker domain. Confers resistance to some lincosamide and nucleoside antibiotics. antibiotic_resistance ARO:3007646 Neobacillus vireti vmlR2 vmlR2 is an ABC-F ATPase ribosomal protection protein from Neobacillus vireti (formerly known as Bacillus vireti). This representative of the ARE2 subfamily has an unusually long linker domain. Confers resistance to some lincosamide and nucleoside antibiotics. PMID:36951104 PSZ beta-lactamases are a novel AmpC enzyme gene family, which was found on a strain of Pantoea endophytica isolated from a rabbit in a livestock farm in China. It shows resistance to penicillins and several cephalosporins, and shares the highest amino acid similarity with the function-characterized AmpC enzyme ERH-1. antibiotic_resistance ARO:3007647 PSZ beta-lactamase PSZ beta-lactamases are a novel AmpC enzyme gene family, which was found on a strain of Pantoea endophytica isolated from a rabbit in a livestock farm in China. It shows resistance to penicillins and several cephalosporins, and shares the highest amino acid similarity with the function-characterized AmpC enzyme ERH-1. PMID:37529328 PSZ-1 is a PSZ beta-lactamase found in Pantoea endophytica. The gene showed resistance to penicillins and several first-, second-and third-generation cephalosporins as well as aztreonam. PSZ-1 antibiotic_resistance ARO:3007648 PSZ-1 PSZ-1 is a PSZ beta-lactamase found in Pantoea endophytica. The gene showed resistance to penicillins and several first-, second-and third-generation cephalosporins as well as aztreonam. PMID:37529328 PSZ-1 A CDA beta-lactamase was identified as a novel class C enzyme that was phylogenetically and biochemically close to the chromosome-borne beta-lactamases of the genera Enterobacter and Citrobacter. antibiotic_resistance ARO:3007649 CDA beta-lactamase A CDA beta-lactamase was identified as a novel class C enzyme that was phylogenetically and biochemically close to the chromosome-borne beta-lactamases of the genera Enterobacter and Citrobacter. PMID:25136020 CDA-1 was recovered from a urine sample and is intermediate or resistant to third-generation cephalosporins and carbapenems. Susceptibility testing, isoelectric focusing, and analysis of outer membrane proteins showed that AmpC beta-lactamase expression combined with porin deficiency accounted for the carbapenem resistance. CDA-1 antibiotic_resistance ARO:3007650 CDA-1 CDA-1 was recovered from a urine sample and is intermediate or resistant to third-generation cephalosporins and carbapenems. Susceptibility testing, isoelectric focusing, and analysis of outer membrane proteins showed that AmpC beta-lactamase expression combined with porin deficiency accounted for the carbapenem resistance. PMID:25136020 CDA-1 Carmoisine is widely used as a food coloring agent. Carmoisine-mediated reduction of biofilm in Pseudomonas aeruginosa is due to its interaction with LasR and interference with the QS system. pubchem.compound:19118 antibiotic_resistance ARO:3007651 carmoisine Carmoisine is widely used as a food coloring agent. Carmoisine-mediated reduction of biofilm in Pseudomonas aeruginosa is due to its interaction with LasR and interference with the QS system. PMID:37485898 Lipoxin A4 is a Specialized Pro-resolving Mediator and has direct effects on P. aeruginosa where it reduced biofilm formation and promoted ciprofloxacin antibiotic efficacy in a static biofilm-forming system. Further studies show lipoxin A4 can help antibiotic efficacy and promote monocyte activity against established P. aeruginosa biofilm formed under hydrodynamic conditions. pubchem.compound:5280914 LxA4 antibiotic_resistance ARO:3007652 lipoxin A4 Lipoxin A4 is a Specialized Pro-resolving Mediator and has direct effects on P. aeruginosa where it reduced biofilm formation and promoted ciprofloxacin antibiotic efficacy in a static biofilm-forming system. Further studies show lipoxin A4 can help antibiotic efficacy and promote monocyte activity against established P. aeruginosa biofilm formed under hydrodynamic conditions. PMID:37462621 The production of pyocyanin by Pseudomonas aeruginosa increases its virulence, fitness and biofilm formation. Ascorbic acid combined with furanone-30 elevated quorum-sensing inhibition in P. aeruginosa, which was directly associated with significantly reduced virulence, adhesion, aggregation and biofilm formation and enhanced antibiotic-mediated bacterial killing. pubchem.compound:54670067 antibiotic_resistance ARO:3007653 ascorbic acid The production of pyocyanin by Pseudomonas aeruginosa increases its virulence, fitness and biofilm formation. Ascorbic acid combined with furanone-30 elevated quorum-sensing inhibition in P. aeruginosa, which was directly associated with significantly reduced virulence, adhesion, aggregation and biofilm formation and enhanced antibiotic-mediated bacterial killing. PMID:37520362 Erm(56) is an Erm ribosomal RNA methyltransferase. Expression of the cloned erm(56) confers resistance to MLSB in T. pyogenes and Escherichia coli. erm(56) antibiotic_resistance ARO:3007654 erm(56) Erm(56) is an Erm ribosomal RNA methyltransferase. Expression of the cloned erm(56) confers resistance to MLSB in T. pyogenes and Escherichia coli. PMID:37417762 erm(56) Nifuroxazide is an oral nitrofuran antibiotic used to treat colitis and diarrhea in humans and non-humans. It has recently been explored to be repurposed for parasitic diseases. pubchem.compound:5337997 antibiotic_resistance ARO:3007655 nifuroxazide Nifuroxazide is an oral nitrofuran antibiotic used to treat colitis and diarrhea in humans and non-humans. It has recently been explored to be repurposed for parasitic diseases. PMID:37409934 Inactivation of the F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents plays a role in antibiotic resistance. antibiotic_resistance ARO:3007656 antibiotic resistant Mycobacterium tuberculosis nitroreductase Inactivation of the F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents plays a role in antibiotic resistance. PMID:36409105 Efflux pumps also regulate the level of metal ions in the cytoplasm but are toxic when in excess. Metals often act as a facilitator in the proliferation and persistence of antibiotic resistance. Therefore, metal contamination in natural environments could have an important role in maintaining and promoting antibiotic resistance. The presence of metals co-selects for antibiotic resistance and leads to the development of cross-resistance. Micro-organisms adopt various mechanisms that may confer resistance against more than one antimicrobial, of which multidrug efflux systems are the most common. antibiotic_resistance ARO:3007657 metal transporters with antibiotic efflux Efflux pumps also regulate the level of metal ions in the cytoplasm but are toxic when in excess. Metals often act as a facilitator in the proliferation and persistence of antibiotic resistance. Therefore, metal contamination in natural environments could have an important role in maintaining and promoting antibiotic resistance. The presence of metals co-selects for antibiotic resistance and leads to the development of cross-resistance. Micro-organisms adopt various mechanisms that may confer resistance against more than one antimicrobial, of which multidrug efflux systems are the most common. PMID:36282241 Albicidin phytotoxins produced by the sugarcane pathogen Xanthomonas albilineans is a potent DNA gyrase inhibitor with inhibitory effects significantly better than most DNA gyrase inhibitors. Albicidin acts primarily by inhibiting the religation of the cleaved DNA intermediate during the gyrase catalytic sequence similar to quinolones. pubchem.compound:78322514 antibiotic_resistance ARO:3007658 albicidin Albicidin phytotoxins produced by the sugarcane pathogen Xanthomonas albilineans is a potent DNA gyrase inhibitor with inhibitory effects significantly better than most DNA gyrase inhibitors. Albicidin acts primarily by inhibiting the religation of the cleaved DNA intermediate during the gyrase catalytic sequence similar to quinolones. PMID:17074789 PMID:31451755 Ectopic expression of NiCoT in Escherichia coli CS109 resulted in the increase of intracellular nickel uptake with enhanced tolerance towards several antibiotics when NiCoT was overexpressed in E. coli and Mycobacterium smegmatis. The presence of a sub-inhibitory dose of nickel resulted in the manifestation of low-level tolerance towards these drugs. NiCoT NicT Rv2856 antibiotic_resistance ARO:3007659 putative nickel/cobalt transporter Ectopic expression of NiCoT in Escherichia coli CS109 resulted in the increase of intracellular nickel uptake with enhanced tolerance towards several antibiotics when NiCoT was overexpressed in E. coli and Mycobacterium smegmatis. The presence of a sub-inhibitory dose of nickel resulted in the manifestation of low-level tolerance towards these drugs. PMID:36282241 Rv2856 Clerocidin is a terpenoid antibiotic that inhibits bacterial DNA gyrase. It is a natural diterpenoid which has been shown to selectively react with single-stranded bases without targeting the double helix. pubchem.compound:9896400 antibiotic_resistance ARO:3007660 clerocidin Clerocidin is a terpenoid antibiotic that inhibits bacterial DNA gyrase. It is a natural diterpenoid which has been shown to selectively react with single-stranded bases without targeting the double helix. PMID:12930966 ddn is a protein-coding gene involved in the bioreductive activation of bicyclic 4-nitroimidazole prodrugs such as PA-824 and delamanid developed for anti-tuberculosis therapy against both replicating and persistent bacteria. Mtub_ddn_MULT antibiotic_resistance ARO:3007661 Mycobacterium tuberculosis ddn mutation conferring resistance to nitroimidazole antibiotics ddn is a protein-coding gene involved in the bioreductive activation of bicyclic 4-nitroimidazole prodrugs such as PA-824 and delamanid developed for anti-tuberculosis therapy against both replicating and persistent bacteria. PMID:36409105 Mtub_ddn_MULT Rv1877, a putative Major Facilitator Superfamily efflux pump from M. tuberculosis actively effluxes fluoroquinolones ofloxacin and levofloxacin. Rv1877 antibiotic_resistance ARO:3007662 Rv1877 Rv1877, a putative Major Facilitator Superfamily efflux pump from M. tuberculosis actively effluxes fluoroquinolones ofloxacin and levofloxacin. PMID:36125560 Rv1877 Stress-activated protein kinases (SAPK) are kinases involved in cellular response to stress whose absence confers resistance to antifungal drug compounds. antibiotic_resistance ARO:3007663 stress-activated protein kinases Stress-activated protein kinases (SAPK) are kinases involved in cellular response to stress whose absence confers resistance to antifungal drug compounds. PMID:30355673 Hog1 is a stress-activated protein kinase. Deletion of Hog1 confers resistance to caspofungin through increase in exposed chitin levels in the cell wall. antibiotic_resistance ARO:3007664 Candida spp. High Osmolarity Glycerol 1 conferring resistance to caspofungin via absence Hog1 is a stress-activated protein kinase. Deletion of Hog1 confers resistance to caspofungin through increase in exposed chitin levels in the cell wall. PMID:30355673 FCY2 encodes for purine-cytosine permease in fungal cells. Downregulation or absence of FCY2 confers resistance to antibiotics by preventing entry into the cell. antibiotic_resistance ARO:3007665 Candida spp. FCY2 conferring resistance to 5-flucytosine via reduced permeability Candida spp. cyp51A1 is a fungal cytochrome P450 enzyme with mutations in the gene causing triazole and imidazole resistance. antibiotic_resistance ARO:3007666 Candida spp. cyp51A1 with mutations conferring resistance to triazoles and imidazole antibiotics Candida spp. cyp51A1 is a fungal cytochrome P450 enzyme with mutations in the gene causing triazole and imidazole resistance. PMID:9527767 Fungal cytochrome P450 enzymes which include mutations to confer resistance to imidazole-class antibiotics. antibiotic_resistance ARO:3007667 imidazole-resistant fungal cytochrome P450 enzyme Fungal cytochrome P450 enzymes which include mutations to confer resistance to imidazole-class antibiotics. PMID:9527767 HMG-CoA reductase-encoding genes which include mutations to confer resistance to antifungal drug compounds. antibiotic_resistance ARO:3007668 HMG-CoA reductase-encoding genes HMG-CoA reductase-encoding genes which include mutations to confer resistance to antifungal drug compounds. PMID:30940706 The AadT pump is a novel multidrug efflux pump from the proton antiporter 2 (DHA2) family and was discovered in Acinetobacter multidrug resistance plasmids. The presence of AadT decreased bacterial susceptibility to antibiotics (erythromycin and tetracycline), biocides (chlorhexidine), and dyes (ethidium bromide and DAPI) and was able to mediate ethidium transport. aadT antibiotic_resistance ARO:3007669 aadT The AadT pump is a novel multidrug efflux pump from the proton antiporter 2 (DHA2) family and was discovered in Acinetobacter multidrug resistance plasmids. The presence of AadT decreased bacterial susceptibility to antibiotics (erythromycin and tetracycline), biocides (chlorhexidine), and dyes (ethidium bromide and DAPI) and was able to mediate ethidium transport. PMID:37252766 aadT Hmg1 is an HMG-CoA reductase-encoding gene with mutations in the gene causing triazole resistance. antibiotic_resistance ARO:3007670 Aspergillus spp. Hmg1 with mutations conferring resistance to triazoles antibiotics Hmg1 is an HMG-CoA reductase-encoding gene with mutations in the gene causing triazole resistance. PMID:30940706 Clostridioides difficile nimB is a heme-dependent flavin enzyme that degrades nitroimidazoles to amines lacking antimicrobial activity. NimB expression alone is not sufficient for nitroimidazole resistance. Constitutive transcription of nimB, which is driven by a mutation in the promoter PnimBG, is a mechanism of clinically-relevant heme-dependent metronidazole resistance in C. difficile. C. difficile nimB CdnimB antibiotic_resistance ARO:3007671 Clostridioides difficile nimB Clostridioides difficile nimB is a heme-dependent flavin enzyme that degrades nitroimidazoles to amines lacking antimicrobial activity. NimB expression alone is not sufficient for nitroimidazole resistance. Constitutive transcription of nimB, which is driven by a mutation in the promoter PnimBG, is a mechanism of clinically-relevant heme-dependent metronidazole resistance in C. difficile. PMID:37438331 CdnimB Rv0678 encodes a transcription factor which negatively regulates the expression of the mmpS5/L5 efflux pump. antibiotic_resistance ARO:3007672 antibiotic resistant Rv0678 Rv0678 encodes a transcription factor which negatively regulates the expression of the mmpS5/L5 efflux pump. PMID:37280265 Loss-of-function mutations in rv0678 are a common mechanism of resistance. antibiotic_resistance ARO:3007673 bedaquiline resistant Rv0678 Loss-of-function mutations in rv0678 are a common mechanism of resistance. PMID:37280265 Rv0678 encodes a transcription factor which negatively regulates the expression of the mmpS5/L5 efflux pump. Loss-of-function mutations in rv0678 are a common mechanism of resistance. Mtub_Rv0678_BDQ antibiotic_resistance ARO:3007674 Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to bedaquiline Rv0678 encodes a transcription factor which negatively regulates the expression of the mmpS5/L5 efflux pump. Loss-of-function mutations in rv0678 are a common mechanism of resistance. PMID:37280265 Mtub_Rv0678_BDQ Famotidine enhances the antibacterial activity of rifamycin antibiotics, especially rifampicin, against Gram-negative bacteria and reverses drug resistance. Famotidine disrupts the cell membrane of A. baumannii and inhibits the expression of the outer membrane protein ompA gene, while causing a dissipation of the plasma membrane potential which increases the accumulation of reactive oxygen species leading to increased bacterial mortality. Famotidine also inhibited the efflux pump activity and the biofilm formation of A. baumannii. pubchem.compound:5702160 antibiotic_resistance ARO:3007675 famotidine Famotidine enhances the antibacterial activity of rifamycin antibiotics, especially rifampicin, against Gram-negative bacteria and reverses drug resistance. Famotidine disrupts the cell membrane of A. baumannii and inhibits the expression of the outer membrane protein ompA gene, while causing a dissipation of the plasma membrane potential which increases the accumulation of reactive oxygen species leading to increased bacterial mortality. Famotidine also inhibited the efflux pump activity and the biofilm formation of A. baumannii. PMID:37439688 An oxacephem is a beta-lactam molecule similar to a cephem, but with an oxygen substituted for the sulfur. They show marked enhancement in their antibacterial activity. antibiotic_resistance ARO:3007676 oxacephem An oxacephem is a beta-lactam molecule similar to a cephem, but with an oxygen substituted for the sulfur. They show marked enhancement in their antibacterial activity. PMID:37610203 Furazidin is a nitrofuran derivative, acting as an antibacterial medicine with bacteriostatic action. It is active against both gram-positive and gram-negative bacteria. It is used for the treatment of urinary tract, skin, and soft tissues infections. pubchem.compound:6870646 furagin furazidine antibiotic_resistance ARO:3007677 furazidin Furazidin is a nitrofuran derivative, acting as an antibacterial medicine with bacteriostatic action. It is active against both gram-positive and gram-negative bacteria. It is used for the treatment of urinary tract, skin, and soft tissues infections. PMID:37629208 E. faecalis IreK maintains cell wall integrity, possibly by regulating peptidoglycan biosynthesis and metabolism. Antibiotic-induced cell wall stress leads to activation of IreK-mediated phosphorylation signaling pathways to mitigate and repair the damage. Absence of IreK leads to cell envelope defects and increased susceptibility to a variety of cephalosporins, including ceftriaxone. Increased IreK phosphorylation in response to ceftriaxone treatment has been shown to correlate with antimicrobial resistance. IreK antibiotic_resistance ARO:3007678 IreK E. faecalis IreK maintains cell wall integrity, possibly by regulating peptidoglycan biosynthesis and metabolism. Antibiotic-induced cell wall stress leads to activation of IreK-mediated phosphorylation signaling pathways to mitigate and repair the damage. Absence of IreK leads to cell envelope defects and increased susceptibility to a variety of cephalosporins, including ceftriaxone. Increased IreK phosphorylation in response to ceftriaxone treatment has been shown to correlate with antimicrobial resistance. PMID:34672600 PMID:37517789 IreK Chrysomycin A (ChryA) is a benzonaphthopyranone glycoside with rapid bactericidal activity that is highly active against S. aureus persisters, robustly eradicates biofilms in vitro, and shows a sustainable killing efficacy in vivo. Chrysomycin A belongs to the coumarin class of antibiotics which are known to bind gyrase subunit B and inhibit the enzyme function. pubchem.compound:73468 ChryA antibiotic_resistance ARO:3007679 chrysomycin A Chrysomycin A (ChryA) is a benzonaphthopyranone glycoside with rapid bactericidal activity that is highly active against S. aureus persisters, robustly eradicates biofilms in vitro, and shows a sustainable killing efficacy in vivo. Chrysomycin A belongs to the coumarin class of antibiotics which are known to bind gyrase subunit B and inhibit the enzyme function. PMID:37540745 2,4-diacetylphloroglucinol (DAPG) is a broad-spectrum antibiotic that was originally isolated from a fluorescent Pseudomonas strain. DAPG is active against numerous organisms, including plants, fungi, viruses, bacteria, and nematodes, and production or increased production of DAPG has been associated with enhanced activity against plant pathogens. pubchem.compound:16547 DAPG antibiotic_resistance ARO:3007680 2,4-diacetylphloroglucinol 2,4-diacetylphloroglucinol (DAPG) is a broad-spectrum antibiotic that was originally isolated from a fluorescent Pseudomonas strain. DAPG is active against numerous organisms, including plants, fungi, viruses, bacteria, and nematodes, and production or increased production of DAPG has been associated with enhanced activity against plant pathogens. PMID:37653049 MdtQ is a putative multidrug resistance outer membrane protein found in carbapenem resistant Klebsiella pneumoniae. MdtQ antibiotic_resistance ARO:3007682 MdtQ MdtQ is a putative multidrug resistance outer membrane protein found in carbapenem resistant Klebsiella pneumoniae. PMID:37640276 MdtQ The eukaryotic-type Ser/Thr kinase (STKs) IreK (intrinsic resistance of enterococci kinase) belongs to a family of transmembrane kinases defined by the presence of multiple extracellular PASTA (penicillin-binding protein and serine/threonine kinase associated) domains. In prokaryotes, STKs modulate cellular functions such as growth, differentiation, and secondary metabolism. When the external environment changes, prokaryotes rely on signal transduction systems, including STKs that quickly sense these changes and alter gene expression to induce the appropriate metabolic changes. STK ser/thr kineases antibiotic_resistance ARO:3007683 Serine/threonine kinases The eukaryotic-type Ser/Thr kinase (STKs) IreK (intrinsic resistance of enterococci kinase) belongs to a family of transmembrane kinases defined by the presence of multiple extracellular PASTA (penicillin-binding protein and serine/threonine kinase associated) domains. In prokaryotes, STKs modulate cellular functions such as growth, differentiation, and secondary metabolism. When the external environment changes, prokaryotes rely on signal transduction systems, including STKs that quickly sense these changes and alter gene expression to induce the appropriate metabolic changes. PMID:22045988 PMID:28698584 PMID:34672600 Mutations in mgrB transmembrane proteins can confer resistance to the antibiotic colistin. antibiotic_resistance ARO:3007684 transmembrane protein conferring colistin resistance Mutations in mgrB transmembrane proteins can confer resistance to the antibiotic colistin. PMID:25190723 Nifuratel is a nitrofuran antibiotic already in use for parasitic infections. It was effective against different serovars, including multidrug-resistant strains of Salmonella Typhimurium, and in macrophages from different host species and against Listeria monocytogenes and Shigella flexneri. It reduced IL-10 and STAT3 production in infected macrophages which should increase the inflammatory response against Salmonella. pubchem.compound:6433427 antibiotic_resistance ARO:3007685 nifuratel Nifuratel is a nitrofuran antibiotic already in use for parasitic infections. It was effective against different serovars, including multidrug-resistant strains of Salmonella Typhimurium, and in macrophages from different host species and against Listeria monocytogenes and Shigella flexneri. It reduced IL-10 and STAT3 production in infected macrophages which should increase the inflammatory response against Salmonella. PMID:37732770 Mutanobactin is produced by a polyketide synthase-nonribosomal peptide synthetase hybrid system encoded by the mub locus. Mutanobactin-producing S. mutans inhibits planktonic and biofilm growth of E. faecalis and is active against other Enterococcus species and Staphylococcus aureus. pubchem.compound:49850903 antibiotic_resistance ARO:3007686 mutanobactin Mutanobactin is produced by a polyketide synthase-nonribosomal peptide synthetase hybrid system encoded by the mub locus. Mutanobactin-producing S. mutans inhibits planktonic and biofilm growth of E. faecalis and is active against other Enterococcus species and Staphylococcus aureus. PMID:37745448 Zidovudine is an antibiotic used in the management and treatment of HIV-1. It is in the nucleoside reverse transcriptase inhibitor class of medications. pubchem.compound:35370 azidothymidine antibiotic_resistance ARO:3007687 zidovudine Zidovudine is an antibiotic used in the management and treatment of HIV-1. It is in the nucleoside reverse transcriptase inhibitor class of medications. PMID:37660210 Menadione exhibits antibacterial activity against methicillin-sensitive and methicillin-resistant S. aureus strains. When combined with oxacillin, it exhibited an additive and synergistic effect against the tested strains. Menadione demonstrated antibiofilm activity and effectively combated biofilms with reduced sensitivity to oxacillin alone. Its mechanism of action involves the production of reactive oxygen species (ROS) and DNA damage. It showed interactions with important targets, such as DNA gyrase and dehydroesqualene synthase. pubchem.compound:4055 vitamin K3 antibiotic_resistance ARO:3007688 menadione Menadione exhibits antibacterial activity against methicillin-sensitive and methicillin-resistant S. aureus strains. When combined with oxacillin, it exhibited an additive and synergistic effect against the tested strains. Menadione demonstrated antibiofilm activity and effectively combated biofilms with reduced sensitivity to oxacillin alone. Its mechanism of action involves the production of reactive oxygen species (ROS) and DNA damage. It showed interactions with important targets, such as DNA gyrase and dehydroesqualene synthase. PMID:37707372 Selamectin is a topical antiparasitic medication for dogs and cats prescribed for various parasite infections. Exposure caused relevant cell surface alterations. A synergistic effect was observed between ampicillin and selamectin. Selamectin may represent a timely and promising macrocyclic lactone for the treatment of S. aureus infections. pubchem.compound:9578507 antibiotic_resistance ARO:3007689 selamectin Selamectin is a topical antiparasitic medication for dogs and cats prescribed for various parasite infections. Exposure caused relevant cell surface alterations. A synergistic effect was observed between ampicillin and selamectin. Selamectin may represent a timely and promising macrocyclic lactone for the treatment of S. aureus infections. PMID:37764086 Rv2535c or pepQ encodes a putative Xaa-Pro aminopeptidase and is a new genetic determinant of low-level bedaquiline and clofazimine cross-resistance in Mycobacterium tuberculosis when mutated. antibiotic_resistance ARO:3007690 antibiotic resistant Rv2535c Rv2535c or pepQ encodes a putative Xaa-Pro aminopeptidase and is a new genetic determinant of low-level bedaquiline and clofazimine cross-resistance in Mycobacterium tuberculosis when mutated. PMID:27185800 Loss-of-function mutations in Rv2535c are a common mechanism of resistance. antibiotic_resistance ARO:3007691 bedaquiline resistant Rv2535c Loss-of-function mutations in Rv2535c are a common mechanism of resistance. PMID:27185800 These pepQ/Rv2535c mutations increase efflux through the mmpL5-mmpS5 (Rv0676c-Rv0677c) transporter, such as preventing degradation of MmpL5, which leads to reduced susceptibility to bedaquiline and clofazimine. Mtub_Rv2535_BDQ Rv2535c pepQ antibiotic_resistance ARO:3007692 Mycobacterium tuberculosis Rv2535c with mutation conferring resistance to bedaquiline These pepQ/Rv2535c mutations increase efflux through the mmpL5-mmpS5 (Rv0676c-Rv0677c) transporter, such as preventing degradation of MmpL5, which leads to reduced susceptibility to bedaquiline and clofazimine. PMID:27185800 Mtub_Rv2535_BDQ The AMZ genes showed resistance against some beta-lactam antibiotics, including amoxicillin and cephalothin, and the beta-lactamase AMZ-1 exhibited a similar substrate spectrum response. Similar to other AmpC beta-lactamases, AMZ-1 is strongly inhibited by avibactam but much less strongly inhibited by tazobactam. antibiotic_resistance ARO:3007693 AMZ beta-lactamase The AMZ genes showed resistance against some beta-lactam antibiotics, including amoxicillin and cephalothin, and the beta-lactamase AMZ-1 exhibited a similar substrate spectrum response. Similar to other AmpC beta-lactamases, AMZ-1 is strongly inhibited by avibactam but much less strongly inhibited by tazobactam. PMID:37808287 Achromobacter mucicolens Y3, isolated from a goose on a farm in Wenzhou, showed resistance to multiple antibiotics, including penicillins and cephalosporins. AMZ-1 showed resistance to amoxicillin, penicillin G, ampicillin, cephalothin and cefoxitin, and the resistance activity could be inhibited by beta-lactamase inhibitors. AMZ-1 antibiotic_resistance ARO:3007694 AMZ-1 Achromobacter mucicolens Y3, isolated from a goose on a farm in Wenzhou, showed resistance to multiple antibiotics, including penicillins and cephalosporins. AMZ-1 showed resistance to amoxicillin, penicillin G, ampicillin, cephalothin and cefoxitin, and the resistance activity could be inhibited by beta-lactamase inhibitors. PMID:37808287 AMZ-1 We identified ceftazidime/avibactam resistance in E. coli associated with a novel CMY variant. Unlike other AmpC enzymes, CMY-185 appears to require an additional substitution on top of N346Y to confer ceftazidime/avibactam resistance. CMY-185 antibiotic_resistance ARO:3007695 CMY-185 We identified ceftazidime/avibactam resistance in E. coli associated with a novel CMY variant. Unlike other AmpC enzymes, CMY-185 appears to require an additional substitution on top of N346Y to confer ceftazidime/avibactam resistance. PMID:37574665 CMY-185 A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-1. antibiotic_resistance ARO:3007696 OXA-1-like beta-lactamase A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10. antibiotic_resistance ARO:3007697 OXA-10-like beta-lactamase A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114. antibiotic_resistance ARO:3007698 OXA-114-like beta-lactamase A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-12. antibiotic_resistance ARO:3007699 OXA-12-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134. antibiotic_resistance ARO:3007700 OXA-134-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-143. antibiotic_resistance ARO:3007701 OXA-143-like beta-lactamase A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184. antibiotic_resistance ARO:3007702 OXA-184-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-198. antibiotic_resistance ARO:3007703 OXA-198-like beta-lactamase A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2. antibiotic_resistance ARO:3007704 OXA-2-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211. antibiotic_resistance ARO:3007705 OXA-211-like beta-lactamase OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect. antibiotic_resistance ARO:3007706 OXA-213-like beta-lactamase OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect. PMID:24696435 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-214. antibiotic_resistance ARO:3007707 OXA-214-like beta-lactamase A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-22. antibiotic_resistance ARO:3007708 OXA-22-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229. antibiotic_resistance ARO:3007709 OXA-229-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii. antibiotic_resistance ARO:3007710 OXA-23-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-24. antibiotic_resistance ARO:3007711 OXA-24-like beta-lactamase A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-266. antibiotic_resistance ARO:3007712 OXA-266-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-274. antibiotic_resistance ARO:3007713 OXA-274-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286. antibiotic_resistance ARO:3007714 OXA-286-like beta-lactamase A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-294. antibiotic_resistance ARO:3007715 OXA-294-like beta-lactamase A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-364. antibiotic_resistance ARO:3007716 OXA-364-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-372. antibiotic_resistance ARO:3007717 OXA-372-like beta-lactamase A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-42. antibiotic_resistance ARO:3007718 OXA-42-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-427. antibiotic_resistance ARO:3007719 OXA-427-like beta-lactamase A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-46. antibiotic_resistance ARO:3007720 OXA-46-like beta-lactamase OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins. antibiotic_resistance ARO:3007721 OXA-48-like beta-lactamase OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins. PMID:33753332 A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-493. antibiotic_resistance ARO:3007722 OXA-493-like beta-lactamase A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-5. antibiotic_resistance ARO:3007723 OXA-5-like beta-lactamase A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50. antibiotic_resistance ARO:3007724 OXA-50-like beta-lactamase The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance. antibiotic_resistance ARO:3007725 OXA-51-like beta-lactamase The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance. PMID:17724156 PMID:24696435 A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-548. antibiotic_resistance ARO:3007726 OXA-548-like beta-lactamase A subfamily of carbapanem-hydrolyzing class D OXA beta-lactamases derived from OXA-55. antibiotic_resistance ARO:3007727 OXA-55-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-58. antibiotic_resistance ARO:3007728 OXA-58-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-60. antibiotic_resistance ARO:3007729 OXA-60-like beta-lactamase A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61. antibiotic_resistance ARO:3007730 OXA-61-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-62. antibiotic_resistance ARO:3007731 OXA-62-like beta-lactamase A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63. antibiotic_resistance ARO:3007732 OXA-63-like beta-lactamase A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-679. antibiotic_resistance ARO:3007733 OXA-679-like beta-lactamase A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-727. antibiotic_resistance ARO:3007734 OXA-727-like beta-lactamase A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-9. antibiotic_resistance ARO:3007735 OXA-9-like beta-lactamase Dexrazoxane is a medication used in the management and treatment of anthracycline-induced cardiotoxicity and extravasation injuries. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Dexrazoxane is a metal ion chelating agent. pubchem.compound:71384 antibiotic_resistance ARO:3007736 dexrazoxane Dexrazoxane is a medication used in the management and treatment of anthracycline-induced cardiotoxicity and extravasation injuries. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Dexrazoxane is a metal ion chelating agent. PMID:37539785 Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata that has been used in traditional medicine for the treatment of diseases such as cancer, renal, cardiovascular, immunological, and neurological disorders, and even aging. The inhibition of NDM-1 by nordihydroguaiaretic acid involves its direct binding to the active region of NDM-1. pubchem.compound:4534 antibiotic_resistance ARO:3007745 nordihydroguaiaretic acid Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata that has been used in traditional medicine for the treatment of diseases such as cancer, renal, cardiovascular, immunological, and neurological disorders, and even aging. The inhibition of NDM-1 by nordihydroguaiaretic acid involves its direct binding to the active region of NDM-1. PMID:37539785 Embelin is a naturally occurring para-benzoquinone isolated from dried berries of Embelia ribes plants. Embelin has a wide spectrum of biological activities, including antioxidant, antitumor, anti-inflammatory, analgesic, anthelmintic, antifertility and antimicrobial. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Embelin is a metal ion chelating agent. pubchem.compound:3218 antibiotic_resistance ARO:3007746 embelin Embelin is a naturally occurring para-benzoquinone isolated from dried berries of Embelia ribes plants. Embelin has a wide spectrum of biological activities, including antioxidant, antitumor, anti-inflammatory, analgesic, anthelmintic, antifertility and antimicrobial. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Embelin is a metal ion chelating agent. PMID:37539785 Candesartan is an anti-hypertensive drug that was found to have antibacterial activity against MDR S. aureus. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Candesartan is a metal ion chelating agent. pubchem.compound:2540 antibiotic_resistance ARO:3007747 candesartan cilexetil Candesartan is an anti-hypertensive drug that was found to have antibacterial activity against MDR S. aureus. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Candesartan is a metal ion chelating agent. PMID:37539785 The small proline-rich antimicrobial peptide, oncocin, selectively targets Gram-negative bacteria through special transporters such as SmbA to enter cytoplasm. It presents low toxicity to mammalian cells, because they cannot effectively penetrate the mammalian cellular membrane or they are internalized through an endocytotic process to minimize interaction with cytosolic ribosomes. pubchem.compound:46889826 antibiotic_resistance ARO:3007748 oncocin The small proline-rich antimicrobial peptide, oncocin, selectively targets Gram-negative bacteria through special transporters such as SmbA to enter cytoplasm. It presents low toxicity to mammalian cells, because they cannot effectively penetrate the mammalian cellular membrane or they are internalized through an endocytotic process to minimize interaction with cytosolic ribosomes. PMID:29256010 PMID:37797458 Point mutations in Salmonella gallinarum dihydropteroate synthase folP altered the stability of the protein, thus conferring sulfonamide resistance. Sgal_folP_SLF antibiotic_resistance ARO:3007749 Salmonella gallinarum folP with mutation conferring resistance to sulfonamides Point mutations in Salmonella gallinarum dihydropteroate synthase folP altered the stability of the protein, thus conferring sulfonamide resistance. PMID:37906281 Sgal_folP_SLF Betaxolol is a selective beta1 receptor blocker used in the treatment of hypertension and angina, with a 50% inhibitory concentration (IC50) of 19.3 plus or minus 0.9 uM significantly inhibiting the hydrolytic activity of the NDM-1 enzyme and may represent a potential NDM-1 enzyme inhibitor. BET combined with meropenem (MEM) showed bactericidal synergism in vitro. BET inhibited NDM-1 by competitively binding to it and that it can be developed in combination with MEM as a new therapy. pubchem.compound:2369 antibiotic_resistance ARO:3007750 betaxolol Betaxolol is a selective beta1 receptor blocker used in the treatment of hypertension and angina, with a 50% inhibitory concentration (IC50) of 19.3 plus or minus 0.9 uM significantly inhibiting the hydrolytic activity of the NDM-1 enzyme and may represent a potential NDM-1 enzyme inhibitor. BET combined with meropenem (MEM) showed bactericidal synergism in vitro. BET inhibited NDM-1 by competitively binding to it and that it can be developed in combination with MEM as a new therapy. PMID:37686201 Point mutations in Salmonella gyrA that confer resistance to ciprofloxacin and nalidixic acid which are fluoroquinolone antibiotics. Sisa_gyrA_FLO antibiotic_resistance ARO:3007751 Salmonella isangi gyrA conferring resistance to fluoroquinolones Point mutations in Salmonella gyrA that confer resistance to ciprofloxacin and nalidixic acid which are fluoroquinolone antibiotics. PMID:37627729 Sisa_gyrA_FLO Point mutation in Salmonella isangi resulting in fluoroquinolone resistance. Sisa_gyrB_FLO antibiotic_resistance ARO:3007752 Salmonella isangi gyrB conferring resistance to fluoroquinolones Point mutation in Salmonella isangi resulting in fluoroquinolone resistance. PMID:37627729 Sisa_gyrB_FLO Lasalocid is an antibacterial agent and a coccidiostat, which is produced by strains of Streptomyces lasaliensis. Lasalocid is able to make neutral complexes with monovalent and divalent cations and transport them through apolar phase. pubchem.compound:5360807 Lasalocid Lasalocide antibiotic_resistance ARO:3007754 Lasalocid A Lasalocid is an antibacterial agent and a coccidiostat, which is produced by strains of Streptomyces lasaliensis. Lasalocid is able to make neutral complexes with monovalent and divalent cations and transport them through apolar phase. PMID:38069118 Calcimycin (A23187) is a polyether antibiotic and divalent cation ionophore, extracted from Streptomyces chartrecensis. pubchem.compound:11957499 A23187 antibiotic_resistance ARO:3007755 Calcimycin Calcimycin (A23187) is a polyether antibiotic and divalent cation ionophore, extracted from Streptomyces chartrecensis. PMID:38103757 Ophiobolin A is a sesterterpene which was initially isolated as fungal phytotoxins and subsequently shown to possess other biological activities, including anticancer activities. pubchem.compound:5281387 antibiotic_resistance ARO:3007756 ophiobolin A Ophiobolin A is a sesterterpene which was initially isolated as fungal phytotoxins and subsequently shown to possess other biological activities, including anticancer activities. PMID:38131643 Sphaeropsidin A is a tetracyclic pimarane diterpene, first isolated as the main phytotoxin produced by Diplodia cupressir, the causal agent of a severe canker disease of Italian cypress, Cupressus sempervirens L. pubchem.compound:51361447 antibiotic_resistance ARO:3007757 sphaeropsidin A Sphaeropsidin A is a tetracyclic pimarane diterpene, first isolated as the main phytotoxin produced by Diplodia cupressir, the causal agent of a severe canker disease of Italian cypress, Cupressus sempervirens L. PMID:38131643 Fengycin is an antifungal lipopeptide complex produced by Bacillus subtilis strain F-29-3. It inhibits filamentous fungi and is used as an agricultural fungicide. pubchem.compound:443591 antibiotic_resistance ARO:3007758 fengycin Fengycin is an antifungal lipopeptide complex produced by Bacillus subtilis strain F-29-3. It inhibits filamentous fungi and is used as an agricultural fungicide. PMID:29376372 PMID:38092837 Point mutations in 23S rRNA of Treponema pallidum subsp. pallidum (T. pallidum), the noncultivable agent of syphilis, shown clinically to confer resistance to erythromycin, a macrolide antibiotic. Tpal_23S_ERY antibiotic_resistance ARO:3007759 Treponema pallidum 23S rRNA with mutation conferring resistance to erythromycin Point mutations in 23S rRNA of Treponema pallidum subsp. pallidum (T. pallidum), the noncultivable agent of syphilis, shown clinically to confer resistance to erythromycin, a macrolide antibiotic. PMID:10755994 PMID:15247355 PMID:19429763 Tpal_23S_ERY A respiratory system disease which involves the lower respiratory tract. antibiotic_resistance DOID:0050161 lower respiratory tract disease A lung disease characterized by inadequate gas exchange by the respiratory system. antibiotic_resistance DOID:11162 respiratory failure A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia. antibiotic_resistance DOID:11394 adult respiratory distress sydrome A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts. antibiotic_resistance DOID:12716 newborn respiratory distress syndrome A cystitis characterized by a sudden onset or severe symptoms. antibiotic_resistance DOID:13148 acute cystitis A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm. antibiotic_resistance DOID:1579 respiratory system disease An integumentary system disease that is located in the skin. antibiotic_resistance DOID:37 skin disease A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. antibiotic_resistance DOID:850 lung disease A circumscribed area of pus or necrotic debris in the skin. antibiotic_resistance HP:0031292 cutaneous abscess Gram staining is a method for staining and identifying bacteria. It is based on the differential retention of a crystal violet-iodine complex within the cell membrane. The cell wall of gram-positive cells have a thick peptidoglycan layer that retains crystal violet after an alcohol wash (staining black-blue or purple by a counterstain). The cell wall of gram-negative cells have a thinner peptidoglycan layer that does not retain crystal violet after an alcohol wash (staining red after counterstain). Some cells have variable staining in culture (e.g. Bacillus, Clostridium) while others have indeterminate staining due to unique aspects of their cell membrane or wall (e.g. Mycobacterium, Mycoplasma). antibiotic_resistance NCIT:23014 gram stain Gram staining is a method for staining and identifying bacteria. It is based on the differential retention of a crystal violet-iodine complex within the cell membrane. The cell wall of gram-positive cells have a thick peptidoglycan layer that retains crystal violet after an alcohol wash (staining black-blue or purple by a counterstain). The cell wall of gram-negative cells have a thinner peptidoglycan layer that does not retain crystal violet after an alcohol wash (staining red after counterstain). Some cells have variable staining in culture (e.g. Bacillus, Clostridium) while others have indeterminate staining due to unique aspects of their cell membrane or wall (e.g. Mycobacterium, Mycoplasma). PMID:19885931 A method to determine whether microbial growth is affected by an antimicrobial compound. antibiotic_resistance NCIT:85540 microbial susceptibility test A method to determine microbial susceptibility to antibiotics wherein bacteria are inoculated onto agar plates and the antimicrobial agent diffused onto the agar plate from a filter paper disk. An approximate, but not exact, MIC is determined by the diameter of growth inhibition zones. This method has been found to have good correlation between in-vivo data and in-vitro data. Kirby-Bauer disk assay antibiotic_resistance NCIT:85595 disk-diffusion method A method to determine microbial susceptibility to antibiotics wherein bacteria are inoculated onto agar plates and the antimicrobial agent diffused onto the agar plate from a filter paper disk. An approximate, but not exact, MIC is determined by the diameter of growth inhibition zones. This method has been found to have good correlation between in-vivo data and in-vitro data. PMID:29403965 A method to determine microbial susceptibility to antibiotics in which a plastic strip impregnated with the antibiotic of interest is placed on an agar plate that has been inoculated with bacteria. The antibiotic diffuses from the strip producing a concentration gradient of drug on the agar. The point at which the elliptical shaped area of growth inhibition meets the strip is the minimum inhibitory concentration of the drug of interest. antibiotic_resistance NCIT:85596 antimicrobial gradient method (E-test) A method to determine microbial susceptibility to antibiotics in which a plastic strip impregnated with the antibiotic of interest is placed on an agar plate that has been inoculated with bacteria. The antibiotic diffuses from the strip producing a concentration gradient of drug on the agar. The point at which the elliptical shaped area of growth inhibition meets the strip is the minimum inhibitory concentration of the drug of interest. PMID:29403965 A method to determine the minimum inhibitory concentration (MIC) of antibiotics in which growth media is pipetted into a multi-well plate. Each well contains a known concentration of drug which is inoculated with a known quantity of bacteria. The plate is incubated for a specified period of time and each well is assessed for bacterial cell growth. The drug concentration in the first well showing no growth is known as the MIC for that antibiotic. Minimum 2 mL total broth dilution volume. antibiotic_resistance NCIT:85701 macro broth dilution method A method to determine the minimum inhibitory concentration (MIC) of antibiotics in which growth media is pipetted into a multi-well plate. Each well contains a known concentration of drug which is inoculated with a known quantity of bacteria. The plate is incubated for a specified period of time and each well is assessed for bacterial cell growth. The drug concentration in the first well showing no growth is known as the MIC for that antibiotic. Minimum 2 mL total broth dilution volume. PMID:29403965 Skin lesion is a skin and integumentary tissue symptom characterized as an abnormal change in structure of the skin that is especially circumscribed and well defined due to injury or disease. antibiotic_resistance SYMP:0000092 skin lesion The outer epithelial layer of the skin that is superficial to the dermis. antibiotic_resistance UBERON:0001003 skin epidermis A female organ involved in reproduction. antibiotic_resistance UBERON:0003134 female reproductive organ A male organ involved in reproduction. antibiotic_resistance UBERON:0003135 male reproductive organ