Ontology about C. elegans and other nematode phenotypes C elegans Phenotype Ontology C_elegans_phenotype_ontology chris-grove 2024-04-09 Variations in the frequencies of translocations, inversions, deletions, or gene amplifications and variations in chromosome fusion events and or chromosomal loss compared to control. C_elegans_phenotype_ontology WBPhenotype:0000000 chromosome instability Variations in the frequencies of translocations, inversions, deletions, or gene amplifications and variations in chromosome fusion events and or chromosomal loss compared to control. WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in body posture compared to control animals. For example, in C. elegans characteristic sinusoidal body posture is altered. body posture abnormal C_elegans_phenotype_ontology WBPhenotype:0000001 body posture variant Animals exhibit variations in body posture compared to control animals. For example, in C. elegans characteristic sinusoidal body posture is altered. WB:WBPerson557 WB:cab The animal moves or rests with uncharacteristic loss of smooth sinusoidal motion or body posture. Movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control animals. C_elegans_phenotype_ontology WBPhenotype:0000002 kinker The animal moves or rests with uncharacteristic loss of smooth sinusoidal motion or body posture. Movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control animals. WB:WBPerson2021 WB:WBPerson557 WB:WBPerson712 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000003 obsolete flattened locomotion path true Eggs are laid under conditions where egg laying is normally inhibited. Egl c C_elegans_phenotype_ontology WBPhenotype:0000004 Liquid M9. constitutive egg laying Eggs are laid under conditions where egg laying is normally inhibited. WB:cab Eggs are laid at an earlier stage of development, eggs are laid in the presence of inhibitors of egg laying, or the inactive phase of the egg-laying cycle is significantly shorter when compared to control. C_elegans_phenotype_ontology WBPhenotype:0000005 hyperactive egg laying Eggs are laid at an earlier stage of development, eggs are laid in the presence of inhibitors of egg laying, or the inactive phase of the egg-laying cycle is significantly shorter when compared to control. WB:cab Eggs are not laid, laid at a slower rate or eggs are laid at a later stage of development compared to control. Egl d C_elegans_phenotype_ontology WBPhenotype:0000006 egg laying defective Eggs are not laid, laid at a slower rate or eggs are laid at a later stage of development compared to control. WB:WBPaper00004402 WB:WBPaper00004651 WB:WBPaper00005654 WB:WBPaper00006395 WB:WBPaper00024497 WB:WBPaper00025054 WB:cab A worm carcass is formed with retained eggs that hatch inside. Bag C_elegans_phenotype_ontology WBPhenotype:0000007 bag of worms A worm carcass is formed with retained eggs that hatch inside. WB:cab Animals respond to anesthetic at a lower concentration or a shorter exposure compared to control animals. anaesthetic hypersensitive C_elegans_phenotype_ontology WBPhenotype:0000008 anesthetic hypersensitive Animals respond to anesthetic at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of anesthetic that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. anaesthetic resistant C_elegans_phenotype_ontology WBPhenotype:0000009 anesthetic resistant Animals fail to respond to the concentration of anesthetic that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals respond to a specific drug at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000010 drug hypersensitive Animals respond to a specific drug at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of a drug that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Animals are not affected by exposure to the drug. C_elegans_phenotype_ontology WBPhenotype:0000011 drug resistant Animals fail to respond to the concentration of a drug that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Animals are not affected by exposure to the drug. WB:WBPerson557 Formation of dauer larvae under conditions that do not favor dauer formation. Daf c C_elegans_phenotype_ontology WBPhenotype:0000012 dauer constitutive Formation of dauer larvae under conditions that do not favor dauer formation. WB:kmva Failure to form dauer larvae under dauer-inducing conditions. Daf d C_elegans_phenotype_ontology WBPhenotype:0000013 dauer defective Failure to form dauer larvae under dauer-inducing conditions. WB:kmva Variations in the structure, organization or path of axon tracts that grow circumferentially around the animal in a single, directed trajectory to bridge the ventral and dorsal cords, compared to control animals. cord commissures abnormal C_elegans_phenotype_ontology WBPhenotype:0000014 cord commissures variant Variations in the structure, organization or path of axon tracts that grow circumferentially around the animal in a single, directed trajectory to bridge the ventral and dorsal cords, compared to control animals. WB:WBPaper00001499 WB:WBPaper00029065 WB:WBPerson712 Variations in the movement towards typically attractive chemicals. C_elegans_phenotype_ontology WBPhenotype:0000015 positive chemotaxis defective Variations in the movement towards typically attractive chemicals. WB:cab Animals respond to aldicarb at a lower concentration or a shorter exposure compared to control animals. Hic C_elegans_phenotype_ontology WBPhenotype:0000016 aldicarb hypersensitive Animals respond to aldicarb at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of aldicarb that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Ald R Ric C_elegans_phenotype_ontology WBPhenotype:0000017 aldicarb resistant Animals fail to respond to the concentration of aldicarb that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 The contraction and relaxation movements of the pharynx occur at a greater frequency compared to that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0000018 pharyngeal pumping increased The contraction and relaxation movements of the pharynx occur at a greater frequency compared to that observed for control animals. WB:WBPerson712 Pharyngeal pumping motion occurs at a slower rate than control animals. C_elegans_phenotype_ontology WBPhenotype:0000019 pharyngeal pumping reduced Pharyngeal pumping motion occurs at a slower rate than control animals. WB:WBPaper00001709 Pharyngeal pumping motion occurs at intervals that vary from control animals. C_elegans_phenotype_ontology WBPhenotype:0000020 pharyngeal pumping irregular Pharyngeal pumping motion occurs at intervals that vary from control animals. WB:WBPaper00001709 Squat animals are dumpy as homozygotes, but roll as heterozygotes. Sqt C_elegans_phenotype_ontology WBPhenotype:0000021 squat Squat animals are dumpy as homozygotes, but roll as heterozygotes. WB:WBPaper00000906 Animals are longer than control animals at the same developmental stage. Lon C_elegans_phenotype_ontology WBPhenotype:0000022 long Animals are longer than control animals at the same developmental stage. WB:cab WB:cgc31 Animals respond to serotonin at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000023 serotonin hypersensitive Animals respond to serotonin at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of serotonin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000024 serotonin resistant Animals fail to respond to the concentration of serotonin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Fluid-filled blisters appear on the cuticle. Bli C_elegans_phenotype_ontology WBPhenotype:0000025 blistered Fluid-filled blisters appear on the cuticle. WB:WBPaper00004402 WB:WBPaper00005654 WB:WBPaper00006395 WB:WBPaper00024497 WB:cab WB:cgc31 Animals are unable to take up or store lipids. In C. elegans, this defect results in pale, skinny and arrested larva. Lpd C_elegans_phenotype_ontology fat depleted WBPhenotype:0000026 lipid depleted Animals are unable to take up or store lipids. In C. elegans, this defect results in pale, skinny and arrested larva. GO:0006629 WB:WBPaper00005707 WB:WBPerson712 Variations in the chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances compared to control. organism metabolism processing abnormal C_elegans_phenotype_ontology WBPhenotype:0000027 organism metabolism processing variant Variations in the chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances compared to control. GO:0008152 WB:WBPerson2021 WB:WBPerson557 Variations in the processes involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules compared to control. RNA processing abnormal C_elegans_phenotype_ontology WBPhenotype:0000028 RNA processing variant Variations in the processes involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules compared to control. GO:0006396 WB:WBPerson2021 Animals are defective for RNAi introduced by environmental means such as in the cases of RNAi triggered by soaking or feeding. systemic RNAi abnormal C_elegans_phenotype_ontology Environmental RNAi defective WBPhenotype:0000029 systemic RNAi variant Animals are defective for RNAi introduced by environmental means such as in the cases of RNAi triggered by soaking or feeding. WB:WBPaper00029209 WB:WBPaper00030758 WB:WBPerson712 Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) compared to control animals. growth abnormal C_elegans_phenotype_ontology WBPhenotype:0000030 growth variant Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) compared to control animals. GO:0040007 WB:WBPerson2021 Any variation that causes a reduction in growth rate compared to control. Gro C_elegans_phenotype_ontology WBPhenotype:0000031 slow growth Any variation that causes a reduction in growth rate compared to control. WB:WBPaper00004402 WB:WBPaper00004403 WB:WBPaper00004651 WB:WBPaper00004769 WB:WBPaper00005654 WB:WBPaper00006395 WB:WBPaper00024497 WB:WBPerson557 WB:cab Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc. Sck C_elegans_phenotype_ontology WBPhenotype:0000032 sick Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc. WB:WBPaper00000179 WB:WBPaper00000565 WB:WBPerson712 The timing of specific developmental events in some tissues is altered relative to the timing of events in other tissues. WBPhenotype:0000437 heterochronic defect developmental timing abnormal C_elegans_phenotype_ontology WBPhenotype:0000033 Possible XP GO:0040034. developmental timing variant The timing of specific developmental events in some tissues is altered relative to the timing of events in other tissues. WB:cab pmid:6494891 Contents or structures of an embryonic cell are not restricted/localized to the same positions (or poles) compared with control animals. embryonic polarity abnormal C_elegans_phenotype_ontology WBPhenotype:0000034 embryonic polarity variant Contents or structures of an embryonic cell are not restricted/localized to the same positions (or poles) compared with control animals. WB:WBPaper00005079 WB:WBPerson2021 WB:WBPerson712 Any variation in the overall structure or appearance of the animal as it progresses from hatching to adult compared to control animals. larval body morphology abnormal C_elegans_phenotype_ontology larval morphology abnormal WBPhenotype:0000035 larval body morphology variant Any variation in the overall structure or appearance of the animal as it progresses from hatching to adult compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the overall structure or appearance of the animal after it has completed progression through the larval stages compared to control animals. adult body morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000036 adult body morphology variant Any variation in the overall structure or appearance of the animal after it has completed progression through the larval stages compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the overall structure or appearance of fertilized oocytes that are laid compared to those laid by control animals. egg morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000037 egg morphology variant Any variation in the overall structure or appearance of fertilized oocytes that are laid compared to those laid by control animals. WB:WBPaper00001075 WB:WBPerson2021 The animal is ruptured at the vulva and displays an extrusion of internal organs at the site of rupture. Rup C_elegans_phenotype_ontology burst vulva gonad eversion gonad exploded through vulva rupture through vulva WBPhenotype:0000038 exploded through vulva The animal is ruptured at the vulva and displays an extrusion of internal organs at the site of rupture. WB:WBPaper00027633 WB:WBPaper00031094 WB:WBPerson712 Adult life span is either longer or shorter than typical of control animals. Age life span abnormal life span variant C_elegans_phenotype_ontology longevity abnormal WBPhenotype:0000039 life span phenotype Adult life span is either longer or shorter than typical of control animals. GO:0008340 WB:WBPaper00005863 WB:WBPaper00026717 WB:WBPerson557 WB:cab Embryos fail to divide and arrest as one-cell embryos. Emb Ocs C_elegans_phenotype_ontology catastrophic one cell arrest WBPhenotype:0000040 one cell arrest early emb Embryos fail to divide and arrest as one-cell embryos. WB:cab WB:cgc5599 catastrophic one cell arrest WB:cgc5599 Any variation in the process involved in the maintenance of an internal equilibrium of water within an organism, compared to control. osmotic integrity abnormal C_elegans_phenotype_ontology osmoregulation variant WBPhenotype:0000041 osmotic integrity variant Any variation in the process involved in the maintenance of an internal equilibrium of water within an organism, compared to control. GO:0030104 WB:WBPerson2021 The progression through stages between fertilization to hatching are temporally retarded. Sle C_elegans_phenotype_ontology WBPhenotype:0000042 slow embryonic development The progression through stages between fertilization to hatching are temporally retarded. WB:WBPerson712 Variations in the progression time of an animal from pronuclei meeting to adulthood compared to control animals. general pace of development abnormal C_elegans_phenotype_ontology WBPhenotype:0000043 general pace of development variant Variations in the progression time of an animal from pronuclei meeting to adulthood compared to control animals. WB:WBPerson2021 WB:WBPerson557 Egg is smaller or larger compared to eggs of control animals. Emb C_elegans_phenotype_ontology WBPhenotype:0000044 egg size defective early emb Egg is smaller or larger compared to eggs of control animals. WB:cab WB:cgc7141 The developmental progression of an animal after the embryonic stage, over time, from its formation to its mature structure is delayed compared to control. C_elegans_phenotype_ontology WBPhenotype:0000045 developmental delay postembryonic The developmental progression of an animal after the embryonic stage, over time, from its formation to its mature structure is delayed compared to control. WB:WBPaper00025054 WB:cab More than five minutes between AB and P1 divisions. Emb pace of P lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000046 pace of P lineage defective early emb More than five minutes between AB and P1 divisions. WB:cab WB:cgc7141 Variations in the process by which the germ layers become positioned in an embryo compared to control animals. Gastrulation involves the proper ingression of small groups of cells at various times into the blastocoel space. gastrulation abnormal C_elegans_phenotype_ontology WBPhenotype:0000047 gastrulation variant Variations in the process by which the germ layers become positioned in an embryo compared to control animals. Gastrulation involves the proper ingression of small groups of cells at various times into the blastocoel space. WB:WBPaper00027251 WB:WBPerson2021 Variations in the ability of an animal to emerge from the protective egg shell compared to control animals. hatching abnormal C_elegans_phenotype_ontology WBPhenotype:0000048 hatching variant Variations in the ability of an animal to emerge from the protective egg shell compared to control animals. GO:0035188 WB:WBPerson2021 Any variation in the progression of an animal over time, from hatching to adulthood, compared to control. postembryonic development abnormal C_elegans_phenotype_ontology WBPhenotype:0000049 postembryonic development variant Any variation in the progression of an animal over time, from hatching to adulthood, compared to control. WB:WBPerson2021 Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die. Emb C_elegans_phenotype_ontology egg lethal embryonic death inviable zygote WBPhenotype:0000050 embryonic lethal Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die. WB:WBPaper00000179 WB:WBPaper00004403 WB:WBPaper00004540 WB:WBPaper00004651 WB:WBPaper00004769 WB:WBPaper00005654 WB:WBPaper00024497 WB:WBPaper00024925 WB:WBPaper00025054 WB:cab The developmental program does not continue past embryogenesis; stage of arrest is not consistent from animal to animal. Emb Etv C_elegans_phenotype_ontology WBPhenotype:0000051 embryonic terminal arrest variable emb The developmental program does not continue past embryogenesis; stage of arrest is not consistent from animal to animal. GO:0009790 WB:WBPaper00004811 WB:WBPaper00024944 WB:WBPerson712 Lethality caused by the perturbation of maternal gene products that are contributed to oogenesis and are required during embryogenesis. Emb Mel C_elegans_phenotype_ontology WBPhenotype:0000052 maternal effect lethal emb Lethality caused by the perturbation of maternal gene products that are contributed to oogenesis and are required during embryogenesis. WB:WBPaper00001109 WB:WBPerson2021 Movement and elongation ceases at the two-fold stage. The myofilament lattice in body wall muscle cells is variant. However, development in embryos continues. Embryos hatch as inviable larvae. Pat C_elegans_phenotype_ontology active elongation arrest two fold arrest WBPhenotype:0000053 paralyzed arrested elongation two fold Movement and elongation ceases at the two-fold stage. The myofilament lattice in body wall muscle cells is variant. However, development in embryos continues. Embryos hatch as inviable larvae. WB:cab WB:cgc1894 The animal dies at any time between hatching and onset to adulthood. Let Lvl C_elegans_phenotype_ontology larval death WBPhenotype:0000054 larval lethal The animal dies at any time between hatching and onset to adulthood. GO:0002119 WB:WBPerson712 Larvae arrest during early larval development. In C. elegans, this occurs during the L1 or L2 stages of larval development. C_elegans_phenotype_ontology WBPhenotype:0000055 early larval arrest Larvae arrest during early larval development. In C. elegans, this occurs during the L1 or L2 stages of larval development. WB:cab Larvae arrest during late larval development. In C. elegans, larval arrest occurs during the L3 or L4 stages of larval development. C_elegans_phenotype_ontology WBPhenotype:0000056 late larval arrest Larvae arrest during late larval development. In C. elegans, larval arrest occurs during the L3 or L4 stages of larval development. WB:cab Animals die during early larval development. In C.elegans, this occurs during the L1- L2 larval stages of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0000057 early larval lethal Animals die during early larval development. In C.elegans, this occurs during the L1- L2 larval stages of the life cycle. WB:WBPerson2021 Animals die during late larval development. In C. elegans, this occurs during the L3- L4 larval stages of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0000058 late larval lethal Animals die during late larval development. In C. elegans, this occurs during the L3- L4 larval stages of the life cycle. WB:WBPerson2021 The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage. Lva C_elegans_phenotype_ontology WBPhenotype:0000059 larval arrest The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage. WB:WBPaper00002958 WB:WBPerson2021 Premature lethality during the adult stage. When applied to large-scale RNAi screens in C. elegans, this phenotype is present in at least 10% of analyzed worms, or at least 30% in the case of rrf-3 perturbed background. Adl Let C_elegans_phenotype_ontology WBPhenotype:0000060 adult lethal Premature lethality during the adult stage. When applied to large-scale RNAi screens in C. elegans, this phenotype is present in at least 10% of analyzed worms, or at least 30% in the case of rrf-3 perturbed background. WB:WBPaper00004402 WB:WBPaper00005654 WB:WBPaper00006395 WB:cab Adl WB:WBPaper00004402 WB:WBPaper00005654 The duration of viability in the adult phase of the life-cycle surpasses that of control animals. Age C_elegans_phenotype_ontology life span increased longevity increased WBPhenotype:0000061 extended life span The duration of viability in the adult phase of the life-cycle surpasses that of control animals. GO:0008340 WB:WBPerson712 Animals die prematurely at any stage of the life cycle. Let C_elegans_phenotype_ontology WBPhenotype:0000062 lethal Animals die prematurely at any stage of the life cycle. WB:WBPaper00001109 WB:WBPerson2021 Variations that cause developmental progression to cease at different stages of the lifecycle. Var C_elegans_phenotype_ontology WBPhenotype:0000063 terminal arrest variable Variations that cause developmental progression to cease at different stages of the lifecycle. WB:WBPerson2021 WB:WBPerson557 Animals die prematurely at any stage of the life cycle in a sex dependent manner. C_elegans_phenotype_ontology Let WBPhenotype:0000064 sexually dimorphic lethality Animals die prematurely at any stage of the life cycle in a sex dependent manner. WB:WBPerson2021 WB:WBPerson557 XO-bearing individuals die preferentially over other animals in the population. In C.elegans, X0 animals die preferentially over XX animals. Let C_elegans_phenotype_ontology male specific lethality WBPhenotype:0000065 X0 lethal XO-bearing individuals die preferentially over other animals in the population. In C.elegans, X0 animals die preferentially over XX animals. WB:WBPerson363 WB:WBPerson712 XX-bearing individuals die preferentially over other animals in the population. In C.elegans, XX animals die preferentially over X0 animals. C_elegans_phenotype_ontology hermaphrodite specific lethality WBPhenotype:0000066 XX lethal XX-bearing individuals die preferentially over other animals in the population. In C.elegans, XX animals die preferentially over X0 animals. WB:WBPerson363 WB:WBPerson712 Animals exhibit variations in response to stress stimuli compared to control animals. organism stress response abnormal C_elegans_phenotype_ontology WBPhenotype:0000067 organism stress response variant Animals exhibit variations in response to stress stimuli compared to control animals. GO:0006950 WB:WBPerson712 Any variation in the state or activity of a cell (in terms of secretion, enzyme production, gene expression, etc.) in response to high levels of reactive oxygen species, compared to control. oxidative stress response abnormal C_elegans_phenotype_ontology WBPhenotype:0000068 cellular oxidative stress response variant Any variation in the state or activity of a cell (in terms of secretion, enzyme production, gene expression, etc.) in response to high levels of reactive oxygen species, compared to control. GO:0034599 WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the progeny of an animal at any time from its fertilization to adulthood compared to control. progeny abnormal C_elegans_phenotype_ontology WBPhenotype:0000069 progeny variant Any variation in the progression of the progeny of an animal at any time from its fertilization to adulthood compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the structure or organization of the somatic reproductive components of the posterior segment of the male from that observed in control males. In C. elegans, this region of the male includes the terminal canals of the reproductive tract, the digestive tract, and spicule channels along with the male specific sensilla (ray, post-cloacal, hook and spicule) and extends to the tip of the acellular fan. Mab male tail morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000070 male tail morphology variant Animals exhibit variations in the structure or organization of the somatic reproductive components of the posterior segment of the male from that observed in control males. In C. elegans, this region of the male includes the terminal canals of the reproductive tract, the digestive tract, and spicule channels along with the male specific sensilla (ray, post-cloacal, hook and spicule) and extends to the tip of the acellular fan. WB:WBPaper00027278 WB:WBPerson712 Animals exhibit variations in the form, structure or composition of any portion of their anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring) compared to control. head morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000071 head morphology variant Animals exhibit variations in the form, structure or composition of any portion of their anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring) compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of any portion of their anatomy between the head and the tail compared to control animals. body morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000072 body morphology variant Animals exhibit variations in the form, structure or composition of any portion of their anatomy between the head and the tail compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of any portion of the most posterior region of the body compared to control. The anterior bound of the tail is not well defined though it might range from the position of the post-deirids to the opening of the anus (Wormatlas). tail morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000073 tail morphology variant Animals exhibit variations in the form, structure or composition of any portion of the most posterior region of the body compared to control. The anterior bound of the tail is not well defined though it might range from the position of the post-deirids to the opening of the anus (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the set of interactions occurring between a group of genes who depend on each other's individual functions in order to make the aggregate function of the network available to the cell, compared to control. genetic pathway abnormal C_elegans_phenotype_ontology WBPhenotype:0000074 genetic pathway variant Any variation in the set of interactions occurring between a group of genes who depend on each other's individual functions in order to make the aggregate function of the network available to the cell, compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the attachment of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) to the outer body of an animal compared to control (Wormatlas). cuticle attachment abnormal C_elegans_phenotype_ontology WBPhenotype:0000075 cuticle attachment variant Any variation in the attachment of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) to the outer body of an animal compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the adhesion of the layer of cells that cover the external surface of an organism which serves to protect the animal from external environment compared to control. epithelial attachment abnormal C_elegans_phenotype_ontology hypodermal attachment abnormal WBPhenotype:0000076 epithelial attachment variant Variations in the adhesion of the layer of cells that cover the external surface of an organism which serves to protect the animal from external environment compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement. cuticle shedding abnormal C_elegans_phenotype_ontology WBPhenotype:0000077 cuticle shedding defect Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement. GO:0018996 The hypodermal cells, which lie along the lateral body wall to form longitudinal stripes of epithelial cells underlying the alae, are misplaced such that they are stacked along the dorsal-ventral axis rather than forming a continuous row of adjacent cells . C_elegans_phenotype_ontology WBPhenotype:0000078 seam cells stacked The hypodermal cells, which lie along the lateral body wall to form longitudinal stripes of epithelial cells underlying the alae, are misplaced such that they are stacked along the dorsal-ventral axis rather than forming a continuous row of adjacent cells . WB:WBPaper00003081 The small linear ridges running along the lateral lines of the cuticle of adults are branched as opposed to having an unbiforcated arrangement, lengthwise along the body (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000079 branched adult alae The small linear ridges running along the lateral lines of the cuticle of adults are branched as opposed to having an unbiforcated arrangement, lengthwise along the body (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals lack the anterior portion of the pharynx. Aph C_elegans_phenotype_ontology WBPhenotype:0000080 no anterior pharynx Animals lack the anterior portion of the pharynx. WB:WBPerson2021 WB:WBPerson557 The developmental program of the animals does not continue past the first larval stage (L1). C_elegans_phenotype_ontology WBPhenotype:0000081 L1 arrest The developmental program of the animals does not continue past the first larval stage (L1). WB:WBPaper00003179 WB:WBPerson2021 The developmental program of the animals does not continue past the second larval stage (L2). C_elegans_phenotype_ontology WBPhenotype:0000082 L2 arrest The developmental program of the animals does not continue past the second larval stage (L2). WB:WBPaper00003179 WB:WBPerson2021 The developmental program of the animals does not continue past the third larval stage (L3). C_elegans_phenotype_ontology WBPhenotype:0000083 L3 arrest The developmental program of the animals does not continue past the third larval stage (L3). WB:WBPaper00004813 WB:WBPerson2021 The developmental program of the animals does not continue past the fourth larval stage (L4). C_elegans_phenotype_ontology WBPhenotype:0000084 L4 arrest The developmental program of the animals does not continue past the fourth larval stage (L4). WB:WBPaper00003179 WB:WBPerson2021 The intestinal lumen is expanded and can often be shown to be filled with bacteria. This swelling is distinct from distension of the entire intestine (intestinal edema). C_elegans_phenotype_ontology WBPhenotype:0000085 swollen intestinal lumen The intestinal lumen is expanded and can often be shown to be filled with bacteria. This swelling is distinct from distension of the entire intestine (intestinal edema). WB:WBPaper00026641 WB:WBPerson712 Intestine is shrunken and may appear constricted. C_elegans_phenotype_ontology WBPhenotype:0000086 shrunken intestine Intestine is shrunken and may appear constricted. WB:WBPaper00005941 Any variation in the progression of a body wall muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. body wall cell development abnormal C_elegans_phenotype_ontology body wall muscle cell development abnormal WBPhenotype:0000087 body wall cell development variant Any variation in the progression of a body wall muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. WB:WBPerson2021 The arrangement of the principal muscle cell type whose contractile activity generates body motion in the nematode differs from that observed in control animals. In C. elegans they consist of 95 unfused cells in the adult organized into four muscle quadrants. Their sarcomeres are obliquely striated and lie lengthwise along the body wall (Wormatlas). C_elegans_phenotype_ontology body wall muscle displaced WBPhenotype:0000088 body muscle displaced The arrangement of the principal muscle cell type whose contractile activity generates body motion in the nematode differs from that observed in control animals. In C. elegans they consist of 95 unfused cells in the adult organized into four muscle quadrants. Their sarcomeres are obliquely striated and lie lengthwise along the body wall (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals fail to respond to the concentration of alpha amanitin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000089 alpha amanitin resistant Animals fail to respond to the concentration of alpha amanitin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals are deficient in the adhesion of the cuticle to the epidermal surface of the animal. C_elegans_phenotype_ontology hypodermis detached from cuticle WBPhenotype:0000090 epidermis cuticle detached Animals are deficient in the adhesion of the cuticle to the epidermal surface of the animal. WB:WBPerson2021 WB:WBPerson557 The cell(s) whose principal function is to provide contractile forces, is separated from the adjacent epidermis. C_elegans_phenotype_ontology hypodermis detached from muscle WBPhenotype:0000091 epidermis muscle detached The cell(s) whose principal function is to provide contractile forces, is separated from the adjacent epidermis. WB:WBPerson2021 WB:WBPerson557 Any variation in the processes that govern the expansion of intestinal cell populations compared to control. intestinal cell proliferation abnormal C_elegans_phenotype_ontology WBPhenotype:0000092 intestinal cell proliferation variant Any variation in the processes that govern the expansion of intestinal cell populations compared to control. WB:WBPerson2021 The descendants of a particular precursor cell exhibit variations in developmental programs compared to their counterparts in control animals. Lin lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000093 lineage variant The descendants of a particular precursor cell exhibit variations in developmental programs compared to their counterparts in control animals. WB:WBPerson2021 Any variation in the progression of the caudal opening of the rectum in the tail over time compared to control (Wormatlas). anus development abnormal C_elegans_phenotype_ontology WBPhenotype:0000094 anus development variant Any variation in the progression of the caudal opening of the rectum in the tail over time compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The descendants of the M precursor cell exhibit variations in developmental programs compared to their counterparts in control animals. In C. elegans the M lineage is a postembryonic mesodermal lineage. M lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000095 M lineage variant The descendants of the M precursor cell exhibit variations in developmental programs compared to their counterparts in control animals. In C. elegans the M lineage is a postembryonic mesodermal lineage. WB:WBPerson2021 Variations in the progression of the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus (cloacal opening) over time compared to control (Wormatlas). cloacal development abnormal C_elegans_phenotype_ontology WBPhenotype:0000096 cloacal development variant Variations in the progression of the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus (cloacal opening) over time compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The descendants of the AB blastomere exhibit variations in developmental programs compared to their counterparts in control animals. AB lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000097 AB lineage variant The descendants of the AB blastomere exhibit variations in developmental programs compared to their counterparts in control animals. WB:WBPaper00001584 WB:WBPerson2021 Any variation in the progression of the cells that form a narrow passage connecting the posterior bulb of the pharynx to the anterior intestine over time compared to control. In C. elegans this valve is composed of 3 pairs of cells each forming a flattened disc-like ring and is lined by a layer of cuticle (Wormatlas). pharyngeal intestinal valve development abnormal C_elegans_phenotype_ontology WBPhenotype:0000098 pharyngeal intestinal valve development variant Any variation in the progression of the cells that form a narrow passage connecting the posterior bulb of the pharynx to the anterior intestine over time compared to control. In C. elegans this valve is composed of 3 pairs of cells each forming a flattened disc-like ring and is lined by a layer of cuticle (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The descendants of any of the P precursor cells exhibit variations in developmental programs compared to their counterparts in control animals. P lineages abnormal C_elegans_phenotype_ontology WBPhenotype:0000099 P lineages variant The descendants of any of the P precursor cells exhibit variations in developmental programs compared to their counterparts in control animals. WB:WBPerson2021 Cells exhibit variations in their response to ultraviolet radiation compared to that observed in control animals. cell UV response abnormal C_elegans_phenotype_ontology WBPhenotype:0000100 cell UV response variant Cells exhibit variations in their response to ultraviolet radiation compared to that observed in control animals. WB:WBPerson557 Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, UV irradiation, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000101 UV induced apoptosis increased Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, UV irradiation, compared to control. WB:WBPerson712 Animals display variations in the organization, accumulation or distribution of transmitter-containing membrane-bound organelles (synaptic vesicles) compared to that observed in control animals. presynaptic vesicle cluster abnormal C_elegans_phenotype_ontology synaptic vesicle cluster abnormal WBPhenotype:0000102 presynaptic vesicle cluster variant Animals display variations in the organization, accumulation or distribution of transmitter-containing membrane-bound organelles (synaptic vesicles) compared to that observed in control animals. WB:WBPaper00027305 Any variation in the progression of the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes over time compared to control. In C. elegans these contents might include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas). gut granule development abnormal C_elegans_phenotype_ontology WBPhenotype:0000103 gut granule development variant Any variation in the progression of the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes over time compared to control. In C. elegans these contents might include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Contents or structures of a cell are no longer restricted/localized to their typical positions within the cell. cell polarity abnormal C_elegans_phenotype_ontology WBPhenotype:0000104 cell polarity variant Contents or structures of a cell are no longer restricted/localized to their typical positions within the cell. WB:WBPaper00031356 WB:WBPerson2021 WB:WBPerson712 Variations in the progression of a developing oocyte, from diakinesis to metaphase (meiosis I), in response to a signal compared to control animals. Meiotic maturation is accompanied by nuclear envelope breakdown (germinal vesicle breakdown), cytoskeletal rearrangement and meiotic spindle assembly. Oma oocyte meiotic maturation abnormal C_elegans_phenotype_ontology WBPhenotype:0000105 oocyte meiotic maturation variant Variations in the progression of a developing oocyte, from diakinesis to metaphase (meiosis I), in response to a signal compared to control animals. Meiotic maturation is accompanied by nuclear envelope breakdown (germinal vesicle breakdown), cytoskeletal rearrangement and meiotic spindle assembly. GO:0001556 WB:WBPaper00026997 WB:WBPerson2021 Variations in the processes that negatively regulate the meiotic progression of oocytes (exit from diakinesis) in the absence of a signal compared to control animals. inhibition of oocyte maturation abnormal C_elegans_phenotype_ontology WBPhenotype:0000106 inhibition of oocyte maturation variant Variations in the processes that negatively regulate the meiotic progression of oocytes (exit from diakinesis) in the absence of a signal compared to control animals. WB:WBPaper00003371 WB:WBPaper00026997 WB:WBPerson2021 Any variation that alters the control mechanisms that inhibit oocyte maturation and release of a mature oocyte into the spermatheca (for subsequent fertilization), compared to control. inhibition of ovulation abnormal C_elegans_phenotype_ontology WBPhenotype:0000107 inhibition of ovulation variant Any variation that alters the control mechanisms that inhibit oocyte maturation and release of a mature oocyte into the spermatheca (for subsequent fertilization), compared to control. GO:0060280 WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000108 obsolete severe dumpy true OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000109 obsolete moderate dumpy true OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000110 obsolete slightly dumpy true Any variation in the cellular or subcellular distribution of a gene product compared to that observed in control animals. pattern of gene expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000111 pattern of gene expression variant Any variation in the cellular or subcellular distribution of a gene product compared to that observed in control animals. WB:WBPerson2021 Variations in the biogenesis and stability of protein molecules compared to control. protein expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000112 protein expression variant Variations in the biogenesis and stability of protein molecules compared to control. WB:WBPerson2021 Variations in the biogenesis and stability of any class of RNA molecules (rRNAs, miRNAs, tRNAs etc) compared to control. RNA expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000113 RNA expression variant Variations in the biogenesis and stability of any class of RNA molecules (rRNAs, miRNAs, tRNAs etc) compared to control. WB:WBPerson2021 Variations in the biogenesis and stability of messenger RNA molecules compared to control. mRNA expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000114 mRNA expression variant Variations in the biogenesis and stability of messenger RNA molecules compared to control. GO:0050684 WB:WBPerson2021 Any variation in the progression of the anterior portion of the pharynx over time compared to control. In C. elegans the anterior region includes the corpus (procorpus and metacorpus - first bulb). anterior pharynx abnormal C_elegans_phenotype_ontology WBPhenotype:0000115 anterior pharynx variant Any variation in the progression of the anterior portion of the pharynx over time compared to control. In C. elegans the anterior region includes the corpus (procorpus and metacorpus - first bulb). WB:WBPerson2021 WB:WBPerson557 Animals die in between the early and late larval stages. In C. elegans, this occurs during the L2- L3 larval stages of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0000116 mid larval lethal Animals die in between the early and late larval stages. In C. elegans, this occurs during the L2- L3 larval stages of the life cycle. WB:WBPerson2021 Animals die at the L1 stage of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0000117 L1 lethal Animals die at the L1 stage of the life cycle. WB:WBPerson2021 L2 lethal: Animals die at the L2 stage of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0000118 L2 lethal L2 lethal: Animals die at the L2 stage of the life cycle. WB:WBPerson2021 Any change that results in higher than normal levels of protein expression compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000119 protein expression increased Any change that results in higher than normal levels of protein expression compared to control animals. WB:WBPerson557 Any change that results in lower than normal levels of protein expression compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000120 protein expression reduced Any change that results in lower than normal levels of protein expression compared to control animals. WB:kmva Variations in the chemical reactions and pathways resulting in the formation of a protein, compared to control. translation abnormal C_elegans_phenotype_ontology protein synthesis abnormal WBPhenotype:0000121 translation variant Variations in the chemical reactions and pathways resulting in the formation of a protein, compared to control. GO:0006412 WB:WBPerson2021 Any variation in the posttranslational modification of a protein (which may include cleavage of peptide bonds) leading to the attainment of the full functional capacity of the protein compared to control. post translational processing abnormal C_elegans_phenotype_ontology protein processing variant WBPhenotype:0000122 post translational processing variant Any variation in the posttranslational modification of a protein (which may include cleavage of peptide bonds) leading to the attainment of the full functional capacity of the protein compared to control. GO:0016485 WB:WBPerson2021 WB:WBPerson557 Variations that cause a decrease in the expression level of a biological catalyst, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000123 enzyme expression level reduced Variations that cause a decrease in the expression level of a biological catalyst, compared to control animals. WB:WBPerson2021 Any variation that results in a decrease in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). C_elegans_phenotype_ontology WBPhenotype:0000124 enzyme activity reduced Any variation that results in a decrease in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). WB:WBPerson2021 WB:WBPerson557 Any variation that results in an increase in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). C_elegans_phenotype_ontology WBPhenotype:0000125 enzyme activity increased Any variation that results in an increase in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). WB:WBPerson2021 WB:WBPerson557 Variations in the time from pronuclei meeting to furrow initiation during the first cell division compared to control animals. Emb general pace of development abnormal C_elegans_phenotype_ontology WBPhenotype:0000126 general pace of development defective early emb Variations in the time from pronuclei meeting to furrow initiation during the first cell division compared to control animals. WB:cab WB:cgc7141 Characteristic exit from the dauer stage is altered compared to control animals. dauer recovery abnormal C_elegans_phenotype_ontology WBPhenotype:0000127 dauer recovery variant Characteristic exit from the dauer stage is altered compared to control animals. WB:cab Animals are more likely to form dauers at temperatures that do not induce dauer entry in control animals. Hid C_elegans_phenotype_ontology WBPhenotype:0000128 temperature induced dauer formation increased Animals are more likely to form dauers at temperatures that do not induce dauer entry in control animals. WB:cgc424 Animals do not enter dauer at a temperature that induces dauer formation in control animals. C_elegans_phenotype_ontology WBPhenotype:0000129 temperature induced dauer formation defective Animals do not enter dauer at a temperature that induces dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 Animals enter the dauer stage when exposed to lower concentrations or shorter exposure times of chemicals that induce dauer formation compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000130 pheromone induced dauer formation enhanced Animals enter the dauer stage when exposed to lower concentrations or shorter exposure times of chemicals that induce dauer formation compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Animals do not enter dauer when exposed to chemicals that induce dauer formation in control animals. Phd C_elegans_phenotype_ontology WBPhenotype:0000131 pheromone induced dauer formation defective Animals do not enter dauer when exposed to chemicals that induce dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the entry into the dauer stage when exposed to concentrations of chemicals that induce dauer formation in control animals. pheromone induced dauer formation abnormal C_elegans_phenotype_ontology WBPhenotype:0000132 pheromone induced dauer formation variant Animals exhibit variations in the entry into the dauer stage when exposed to concentrations of chemicals that induce dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 The levels of an enzyme involved in the manufacture of lipids are decreased compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000133 expression lipogenic enzyme reduced The levels of an enzyme involved in the manufacture of lipids are decreased compared to control animals. WB:WBPerson2021 Animals exhibit a decrease in the intensity of expression of a gene product compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000134 gene expression level reduced Animals exhibit a decrease in the intensity of expression of a gene product compared to that observed in control animals. WB:WBPerson2021 Animals exhibit an increase in the intensity of expression of a gene product compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000135 gene expression level high Animals exhibit an increase in the intensity of expression of a gene product compared to that observed in control animals. WB:WBPerson2021 Animals exhibit elevated levels of messenger RNA compared to control. C_elegans_phenotype_ontology WBPhenotype:0000136 mRNA levels increased Animals exhibit elevated levels of messenger RNA compared to control. WB:WBPaper00033456 WB:WBPerson2021 Animals exhibit decreased levels of messenger RNA compared to control. C_elegans_phenotype_ontology WBPhenotype:0000137 mRNA levels reduced Animals exhibit decreased levels of messenger RNA compared to control. WB:WBPaper00033456 WB:WBPerson2021 The constituent parts or ratio of elements that make up lipids are altered when compared to that of control animals. lipid composition abnormal C_elegans_phenotype_ontology fat composition abnormal fatty acid composition abnormal WBPhenotype:0000138 lipid composition variant The constituent parts or ratio of elements that make up lipids are altered when compared to that of control animals. WB:WBPerson712 Animals exhibit variations in survival when exposed to stress stimuli that induce lethality in control animals. stress induced lethality abnormal C_elegans_phenotype_ontology WBPhenotype:0000139 stress induced lethality variant Animals exhibit variations in survival when exposed to stress stimuli that induce lethality in control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in cessation of development when exposed to stress stimuli that induce developmental arrest in control animals. stress induced arrest abnormal C_elegans_phenotype_ontology WBPhenotype:0000140 stress induced arrest variant Animals exhibit variations in cessation of development when exposed to stress stimuli that induce developmental arrest in control animals. WB:WBPerson2021 WB:WBPerson557 Animal populations exhibit a further decrease in survival when exposed to stress stimuli compared to the lethality rate observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000141 stress induced lethality increased Animal populations exhibit a further decrease in survival when exposed to stress stimuli compared to the lethality rate observed in control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress, compared to control. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). cell stress response abnormal C_elegans_phenotype_ontology WBPhenotype:0000142 cell stress response variant Variations in the activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress, compared to control. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). GO:0033554 WB:WBPerson2021 Animals exhibit variations in their response to ultraviolet radiation compared to that observed in control animals. organism UV response abnormal C_elegans_phenotype_ontology WBPhenotype:0000143 organism UV response variant Animals exhibit variations in their response to ultraviolet radiation compared to that observed in control animals. WB:WBPerson557 Animals exhibit an increase in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000144 pathogen induced cell death increased Animals exhibit an increase in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control. WB:WBPerson712 Animals exhibit variations in the time of onset or duration of the fertile period, or production of new individuals that contain some portion of their genetic material inherited from that organism compared to control. fertility variant fertility abnormal C_elegans_phenotype_ontology WBPhenotype:0000145 fertility phenotype Animals exhibit variations in the time of onset or duration of the fertile period, or production of new individuals that contain some portion of their genetic material inherited from that organism compared to control. GO:0000003 WB:WBPerson2021 WB:WBPerson557 Animals do not respond to changes in temperature or thermal stress in the same manner as control animals. In C.elegans this is often measured by changes in the expression of stress proteins or changes in life span. organism temperature response abnormal C_elegans_phenotype_ontology WBPhenotype:0000146 organism temperature response variant Animals do not respond to changes in temperature or thermal stress in the same manner as control animals. In C.elegans this is often measured by changes in the expression of stress proteins or changes in life span. WB:WBPerson712 Any variation in the state or activity of an organism as a result of deprivation of nourishment, compared to control. organism starvation response abnormal C_elegans_phenotype_ontology WBPhenotype:0000147 organism starvation response variant Any variation in the state or activity of an organism as a result of deprivation of nourishment, compared to control. GO:0042594 WB:WBPerson2021 Animals exhibit variations in the entry into the dauer stage when exposed to nutrient poor conditions that induce dauer formation in control animals. starvation induced dauer formation abnormal C_elegans_phenotype_ontology WBPhenotype:0000148 starvation induced dauer formation variant Animals exhibit variations in the entry into the dauer stage when exposed to nutrient poor conditions that induce dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 Animals are more likely to form dauers under nutrient conditions that do not induce dauer entry in control animals. C_elegans_phenotype_ontology WBPhenotype:0000149 starvation induced dauer formation increased Animals are more likely to form dauers under nutrient conditions that do not induce dauer entry in control animals. WB:WBPerson2021 WB:WBPerson557 Animals do not enter dauer under nutrient-poor conditions that induce dauer formation in control animals. C_elegans_phenotype_ontology WBPhenotype:0000150 starvation induced dauer formation defective Animals do not enter dauer under nutrient-poor conditions that induce dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 Embryos generate an excess number of anterior derived pharyngeal cells. In C. elegans, embryos generate an excess number of AB blastomere-derived pharyngeal cells. This hyperinduction of anterior pharyngeal tissue is associated with defects in fate specification of the ABp blastomere. Apx C_elegans_phenotype_ontology WBPhenotype:0000151 anterior pharynx extra cells Embryos generate an excess number of anterior derived pharyngeal cells. In C. elegans, embryos generate an excess number of AB blastomere-derived pharyngeal cells. This hyperinduction of anterior pharyngeal tissue is associated with defects in fate specification of the ABp blastomere. WB:WBPaper00001930 WB:WBPerson2021 One-cell embryos do not form the shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis. Emb C_elegans_phenotype_ontology WBPhenotype:0000152 no cleavage furrow first division early emb One-cell embryos do not form the shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis. GO:0032154 WB:WBPerson2021 WB:WBPerson557 Initiation, strength, extent or cessation of body wall muscle activity that results in the shortening of the muscle, is aberrant compared to control animals. body wall contraction variant body wall contraction abnormal C_elegans_phenotype_ontology WBPhenotype:0000153 body wall muscle contraction abnormal Initiation, strength, extent or cessation of body wall muscle activity that results in the shortening of the muscle, is aberrant compared to control animals. WB:WBPaper00032190 WB:WBPerson712 The characteristic number of offspring produced is lower compared to that of control animals. C_elegans_phenotype_ontology WBPhenotype:0000154 reduced brood size The characteristic number of offspring produced is lower compared to that of control animals. WB:WBPerson557 Contents or structures of the cell are oriented on the opposite side of the cell compared to control animals; In C. elegans, this can result in the fate pattern of descendants being flipped. C_elegans_phenotype_ontology WBPhenotype:0000155 cell polarity reversed Contents or structures of the cell are oriented on the opposite side of the cell compared to control animals; In C. elegans, this can result in the fate pattern of descendants being flipped. WB:WBPaper00031356 WB:WBPerson2021 WB:WBPerson712 Any variation in the time interval between successive contractions of the body wall muscles during the defecation motor program compared to cantrol. body wall contraction interval abnormal C_elegans_phenotype_ontology body wall muscle contraction interval abnormal WBPhenotype:0000156 body wall muscle contraction interval during defecation abnormal Any variation in the time interval between successive contractions of the body wall muscles during the defecation motor program compared to cantrol. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the sustained posterior body muscle contractions that precede the remaining contractions of the defecation cycle compared to control animals. pBoc posterior body wall contraction abnormal C_elegans_phenotype_ontology posterior body contraction abnormal posterior body wall contraction defective WBPhenotype:0000157 posterior body wall contraction defecation cycle variant Animals exhibit variations in the sustained posterior body muscle contractions that precede the remaining contractions of the defecation cycle compared to control animals. WB:WBPaper00031426 WB:WBPerson712 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000158 obsolete posterior body wall shortened interval true OBSOLETE: Animals exhibit variations in the entry/exit into a state of arrested tissue development during the dauer larval stage in response to harsh environmental conditions, compared to control. In C. elegans, the dauer larva enters a state of arrest in which no developmental changes occur, until the animal finds more suitable growing conditions, or until it spontaneously shifts back into a normal developmental schedule. (WormAtlas). C_elegans_phenotype_ontology WBPhenotype:0000159 obsolete dauer arrest variant true OBSOLETE: Animals exhibit variations in the entry/exit into a state of arrested tissue development during the dauer larval stage in response to harsh environmental conditions, compared to control. In C. elegans, the dauer larva enters a state of arrest in which no developmental changes occur, until the animal finds more suitable growing conditions, or until it spontaneously shifts back into a normal developmental schedule. (WormAtlas). WB:WBPerson2021 WB:WBPerson557 Embryos do not form a defined shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis. Emb C_elegans_phenotype_ontology WBPhenotype:0000160 cleavage furrow not discrete early emb Embryos do not form a defined shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis. GO:0032154 WB:WBPerson2021 WB:WBPerson557 Any variation in the rotation of centrosomes and associated pronuclei in one-cell embryo, occurring as a transition between pronuclear migration and pronuclear fusion compared to control. nuclear rotation abnormal C_elegans_phenotype_ontology WBPhenotype:0000161 nuclear rotation variant Any variation in the rotation of centrosomes and associated pronuclei in one-cell embryo, occurring as a transition between pronuclear migration and pronuclear fusion compared to control. GO:0035047 WB:WBPerson2021 WB:WBPerson557 Larva show deficiencies in chroma resulting in increased translucency. C_elegans_phenotype_ontology translucent WBPhenotype:0000162 pale larva Larva show deficiencies in chroma resulting in increased translucency. WB:WBPerson2021 WB:WBPerson557 Larva appear unusually transparent when compared to control. Clr C_elegans_phenotype_ontology transparent WBPhenotype:0000163 clear larva Larva appear unusually transparent when compared to control. WB:WBPerson557 Animals exhibit a reduced girth compared to a control animal of the same developmental stage. C_elegans_phenotype_ontology decreased girth slim WBPhenotype:0000164 thin Animals exhibit a reduced girth compared to a control animal of the same developmental stage. WB:WBPerson712 Variations in the ability of two or more individual cells to form a syncytium (a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane) via the fusion of the plasma membranes. Cell fusion is dependent on the merging of lipid bilayer membranes as well as cytoplasmic mixing. cell fusion abnormal C_elegans_phenotype_ontology WBPhenotype:0000165 cell fusion variant Variations in the ability of two or more individual cells to form a syncytium (a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane) via the fusion of the plasma membranes. Cell fusion is dependent on the merging of lipid bilayer membranes as well as cytoplasmic mixing. GO:0000768 GO:0045026 WB:WBPaper00005122 WB:WBPerson2021 Variations in the ability of seam cells to fuse to form a continuous syncytium along the body wall late larval development, (separate from the hyp 7 syncytium), compared to control (WormAtlas). Hypodermal seam cells lie along the lateral body wall to form longitudinal stripes of epithelial cells underlying the alae, and are required for alae formation. seam cell fusion abnormal C_elegans_phenotype_ontology WBPhenotype:0000166 seam cell fusion variant Variations in the ability of seam cells to fuse to form a continuous syncytium along the body wall late larval development, (separate from the hyp 7 syncytium), compared to control (WormAtlas). Hypodermal seam cells lie along the lateral body wall to form longitudinal stripes of epithelial cells underlying the alae, and are required for alae formation. WB:WBPerson2021 WB:WBPerson557 Seam cells fuse to form a continuous syncytium along the body wall at an earlier stage of development compared to control. C_elegans_phenotype_ontology WBPhenotype:0000167 precocious seam cell fusion Seam cells fuse to form a continuous syncytium along the body wall at an earlier stage of development compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the regulated release of proteins needed for alae formation by epidermal seam cells compared to control. Alae are small linear ridges running along the lateral lines of the cuticle, lengthwise along the body (WormAtlas). alae secretion abnormal C_elegans_phenotype_ontology alae formation variant WBPhenotype:0000168 alae secretion variant Variations in the regulated release of proteins needed for alae formation by epidermal seam cells compared to control. Alae are small linear ridges running along the lateral lines of the cuticle, lengthwise along the body (WormAtlas). WB:WBPaper00004833 WB:WBPaper00025242 WB:WBPerson2021 Cells leave the M phase (mitosis and cytokinesis) at an earlier time than sister or other control cells. C_elegans_phenotype_ontology WBPhenotype:0000169 early exit cell cycle Cells leave the M phase (mitosis and cytokinesis) at an earlier time than sister or other control cells. GO:0010458 WB:WBPerson557 WB:WBPerson712 Formation of alae occurs earlier in development compared to control animals; In C. elegans, adult lateral alae are typically generated during the late L4 stage. C_elegans_phenotype_ontology WBPhenotype:0000170 precocious alae Formation of alae occurs earlier in development compared to control animals; In C. elegans, adult lateral alae are typically generated during the late L4 stage. WB:cab pmid:3428573 Any aberrancy in the processes that govern expansion of cell populations compared to control animals. cell proliferation abnormal C_elegans_phenotype_ontology WBPhenotype:0000171 cell proliferation variant Any aberrancy in the processes that govern expansion of cell populations compared to control animals. GO:0008283 WB:WBPerson2021 The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are increased. C_elegans_phenotype_ontology WBPhenotype:0000172 cell proliferation increased The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are increased. WB:WBPerson2021 The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are decreased. C_elegans_phenotype_ontology WBPhenotype:0000173 cell proliferation reduced The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are decreased. WB:WBPerson2021 Any variation in the progression of the layer of connective tissue over the surface of tissues that serves to separate it from neighboring tissues, from its formation to its mature structure compared to control (Wormatlas). basal lamina development abnormal C_elegans_phenotype_ontology WBPhenotype:0000174 basal lamina development variant Any variation in the progression of the layer of connective tissue over the surface of tissues that serves to separate it from neighboring tissues, from its formation to its mature structure compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Excessive and often uncoordinated body wall muscle contraction leading to shortening of the body. C_elegans_phenotype_ontology WBPhenotype:0000175 hypercontracted Excessive and often uncoordinated body wall muscle contraction leading to shortening of the body. WB:WBPerson363 Any variation in the specific actions or reactions of an animal after completion of feeding, typically after a fast, compared to that observed in control animals. In C. elegans worms become behaviorally quiescent and cease feeding and moving when sated. satiety behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000176 satiety behavior variant Any variation in the specific actions or reactions of an animal after completion of feeding, typically after a fast, compared to that observed in control animals. In C. elegans worms become behaviorally quiescent and cease feeding and moving when sated. WB:WBPerson2021 WB:WBPerson557 Any variation that results in a decrease of acetylcholine esterase levels, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000177 acetylcholinesterase reduced Any variation that results in a decrease of acetylcholine esterase levels, compared to control. WB:WBPaper00024452 WB:WBPerson2021 Cells are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles. C_elegans_phenotype_ontology WBPhenotype:0000178 cell degeneration Cells are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles. WB:WBPerson712 Cells specialized for receiving, conducting and transmitting impulses in the nervous system are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles. C_elegans_phenotype_ontology WBPhenotype:0000179 neuron degeneration Cells specialized for receiving, conducting and transmitting impulses in the nervous system are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles. WB:WBPerson712 WB:WBperson557 Animals display variations in the structure, organization of components, or spatial pattern of the projection that conducts signal away from the cell body, compared to that observed in control animals. axon morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000180 axon morphology variant Animals display variations in the structure, organization of components, or spatial pattern of the projection that conducts signal away from the cell body, compared to that observed in control animals. GO:0030424 WB:WBPaper00005236 WB:WBPerson712 Animals display variations in the directed path taken by the axon compared to the path the nerve fiber follows in the nervous system in control animals. axon trajectory abnormal C_elegans_phenotype_ontology WBPhenotype:0000181 axon trajectory variant Animals display variations in the directed path taken by the axon compared to the path the nerve fiber follows in the nervous system in control animals. WB:WBPaper00001105 WB:WBPerson712 Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000182 apoptosis reduced Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals. GO:0043065 WB:WBPerson2021 Any perturbation that causes an elevation in the frequency of cell death by apoptosis compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000183 apoptosis increased Any perturbation that causes an elevation in the frequency of cell death by apoptosis compared to control animals. GO:0043066 WB:WBPerson2021 Cells do not undergo the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. C_elegans_phenotype_ontology WBPhenotype:0000184 apoptosis fails to occur Cells do not undergo the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. WB:WBPerson712 Animals exhibit a decreased pace of the programmed cell death pathway, compared to that observed for control cells. C_elegans_phenotype_ontology WBPhenotype:0000185 apoptosis protracted Animals exhibit a decreased pace of the programmed cell death pathway, compared to that observed for control cells. WB:WBPerson712 Any aberrancy in the processes that influence the generation and maturation of oocytes compared to control animals. WBPhenotype:0000896 oocyte germ cell differentiation abnormal oogenesis abnormal C_elegans_phenotype_ontology oocyte development abnormal WBPhenotype:0000186 oogenesis variant Any aberrancy in the processes that influence the generation and maturation of oocytes compared to control animals. GO:0048477 WB:WBPerson2021 The overall structure or appearance of fertilized oocytes that are laid has every part of their surface equidistant from the center. C_elegans_phenotype_ontology WBPhenotype:0000187 egg round The overall structure or appearance of fertilized oocytes that are laid has every part of their surface equidistant from the center. WB:WBPerson2021 WB:WBPerson557 Any variation in the 'arm-like' form, structure or composition of the specialized tissue of the reproductive tract that produces gametes compared to control. In C. elegans the reproductive tract in the hermaphrodite has two equivalent gonad 'arms', while the male has a one-armed gonad. gonad arm morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000188 gonad arm morphology variant Any variation in the 'arm-like' form, structure or composition of the specialized tissue of the reproductive tract that produces gametes compared to control. In C. elegans the reproductive tract in the hermaphrodite has two equivalent gonad 'arms', while the male has a one-armed gonad. WB:WBPerson2021 WB:WBPerson557 Hypodermal cells fail to be organized in the same manner as observed in control animals. In C. elegans, hypodermal cells typically organize into distinct dorsal, lateral and ventral rows and cover the entire body. C_elegans_phenotype_ontology WBPhenotype:0000189 hypodermis disorganized Hypodermal cells fail to be organized in the same manner as observed in control animals. In C. elegans, hypodermal cells typically organize into distinct dorsal, lateral and ventral rows and cover the entire body. WB:WBPaper00027006 WB:WBPerson2021 Animals fail to exit from the facultative diapause of the dauer larval stage of nematode development. C_elegans_phenotype_ontology WBPhenotype:0000190 no dauer recovery Animals fail to exit from the facultative diapause of the dauer larval stage of nematode development. GO:0043054 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in their response to a situation when there is too high a density of nematodes to be supported by the available amount of food and space compared to that observed in control animals (Wormatlas). organism crowding response abnormal C_elegans_phenotype_ontology WBPhenotype:0000191 organism crowding response variant Animals exhibit variations in their response to a situation when there is too high a density of nematodes to be supported by the available amount of food and space compared to that observed in control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation that results in the misregulation of enzymatic activity such that catalysis occurs at a constant rate regardless of physiological demand or the concentration of a substrate. C_elegans_phenotype_ontology WBPhenotype:0000192 constitutive enzyme activity Any variation that results in the misregulation of enzymatic activity such that catalysis occurs at a constant rate regardless of physiological demand or the concentration of a substrate. WB:WBPerson2021 WB:WBPerson557 Any variation within an enzyme that causes it to act antagonistically towards the wild-type enzymatic product. These mutations usually result in an altered molecular function (often inactive) and are characterized by a dominant or semi-dominant phenotype. C_elegans_phenotype_ontology WBPhenotype:0000193 dominant negative enzyme Any variation within an enzyme that causes it to act antagonistically towards the wild-type enzymatic product. These mutations usually result in an altered molecular function (often inactive) and are characterized by a dominant or semi-dominant phenotype. WB:WBPerson2021 Variations in the placement of the polar body formed in the first division of meiosis of a primary oocyte, compared to control. A polar body is the by-product of meiosis (destined to degenerate) in female or hermaphrodite animals. first polar body position abnormal C_elegans_phenotype_ontology WBPhenotype:0000194 first polar body position variant Variations in the placement of the polar body formed in the first division of meiosis of a primary oocyte, compared to control. A polar body is the by-product of meiosis (destined to degenerate) in female or hermaphrodite animals. WB:WBPerson2021 WB:WBPerson557 Variations in the migration pattern of distal tip cells compared to control animals. In C. elegans, DTCs located on the anterior and posterior ends of the gonad primordium typically migrate in a symmetrical U-shaped pattern. distal tip cell migration abnormal C_elegans_phenotype_ontology DTC migration abnormal WBPhenotype:0000195 distal tip cell migration variant Variations in the migration pattern of distal tip cells compared to control animals. In C. elegans, DTCs located on the anterior and posterior ends of the gonad primordium typically migrate in a symmetrical U-shaped pattern. GO:0040039 WB:WBPaper00003598 WB:WBPerson2021 The morphological appearance of distal tip cells is varied compared to control animals. distal tip cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000196 distal tip cell morphology variant The morphological appearance of distal tip cells is varied compared to control animals. WB:cab Variations in a cell's ability to influence the fate of another cell (often of different developmental potential or ancestry via short range signaling). cell induction abnormal C_elegans_phenotype_ontology WBPhenotype:0000197 cell induction variant Variations in a cell's ability to influence the fate of another cell (often of different developmental potential or ancestry via short range signaling). GO:0031128 WB:WBPerson2021 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000198 obsolete vulval cell induction abnormal true Any variation in the progression of the finger-like sensory sensilla that project from the tail and embed in the male fan from its formation to the mature structure when compared to control animals. male tail sensory ray development abnormal C_elegans_phenotype_ontology WBPhenotype:0000199 male tail sensory ray development variant Any variation in the progression of the finger-like sensory sensilla that project from the tail and embed in the male fan from its formation to the mature structure when compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of structures/tissues surrounding a cell over time from its initial formation to its mature form compared to control. pericellular component development abnormal C_elegans_phenotype_ontology WBPhenotype:0000200 pericellular component development variant Variations in the progression of structures/tissues surrounding a cell over time from its initial formation to its mature form compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time compared to control animals (Wormatlas). cuticle development abnormal C_elegans_phenotype_ontology WBPhenotype:0000201 cuticle development variant Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time compared to control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the small linear ridges running along the lateral lines of the cuticle, lengthwise along the body compared to control (Wormatlas). alae abnormal C_elegans_phenotype_ontology WBPhenotype:0000202 alae variant Any variation in the small linear ridges running along the lateral lines of the cuticle, lengthwise along the body compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the characteristic desensitization to a volatile organic chemo-attractive signal in a time-concentration dependent and reversible manner compared to control animals. odorant adaptation abnormal C_elegans_phenotype_ontology WBPhenotype:0000203 odorant adaptation variant Animals exhibit variations in the characteristic desensitization to a volatile organic chemo-attractive signal in a time-concentration dependent and reversible manner compared to control animals. WB:WBPerson2021 Variations in the anterior body muscle contraction (aBoc) step of the defecation cycle compared to control animals. Under normal conditions, anterior body wall muscles contract and pressurize the intestinal contents during the aBoc step. aBoc C_elegans_phenotype_ontology anterior body contraction abnormal anterior body contraction defective WBPhenotype:0000204 anterior body contraction defecation cycle variant Variations in the anterior body muscle contraction (aBoc) step of the defecation cycle compared to control animals. Under normal conditions, anterior body wall muscles contract and pressurize the intestinal contents during the aBoc step. WB:WBPerson2021 Any variation in the expulsion of gut contents compared to control. In C. elegans, this refers to the final step of the defecation cycle in which the intestinal muscle and anal depressor contractions further pressurize intestinal contents and open the anus to permit expulsion. expulsion abnormal C_elegans_phenotype_ontology Exp WBPhenotype:0000205 expulsion variant Any variation in the expulsion of gut contents compared to control. In C. elegans, this refers to the final step of the defecation cycle in which the intestinal muscle and anal depressor contractions further pressurize intestinal contents and open the anus to permit expulsion. WB:WBPerson2021 WB:WBPerson557 A non-sex chromosome fails to segregate away from its homologous chromosome, resulting in gametes with no or extra copies of the non-sex homolog. C_elegans_phenotype_ontology WBPhenotype:0000206 autosomal nondisjunction meiosis A non-sex chromosome fails to segregate away from its homologous chromosome, resulting in gametes with no or extra copies of the non-sex homolog. GO:0045143 WB:WBPerson712 Any variation in the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control . defecation cycle abnormal C_elegans_phenotype_ontology Dec WBPhenotype:0000207 defecation cycle variant Any variation in the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control . WB:WBPerson2021 WB:WBPerson557 The mean time between the onset of the defecation motor program is greater than that observed for control animals. C_elegans_phenotype_ontology Dec-l reduced rate of defecation WBPhenotype:0000208 long defecation cycle The mean time between the onset of the defecation motor program is greater than that observed for control animals. WB:WBPaper00002315 WB:WBPaper00031896 WB:WBPerson712 The mean time between the onset of the defecation motor program is shorter than that observed for control animals. posterior body wall shortened interval C_elegans_phenotype_ontology Dec-s fast Dec increased rate of defecation WBPhenotype:0000209 short defecation cycle The mean time between the onset of the defecation motor program is shorter than that observed for control animals. WB:WBPaper00002315 WB:WBPaper00031896 WB:WBPerson712 Any variation in the stereotyped muscle contractions that result in defecation compared to control . In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp). defecation contraction abnormal C_elegans_phenotype_ontology WBPhenotype:0000210 defecation contraction variant Any variation in the stereotyped muscle contractions that result in defecation compared to control . In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp). WB:WBPerson2021 WB:WBPerson557 The rhythmic contractions of the muscles coordinating the elimination of gut contents are no longer synchronized compared to control. C_elegans_phenotype_ontology defecation contraction mistimed WBPhenotype:0000211 defecation contraction asynchronous The rhythmic contractions of the muscles coordinating the elimination of gut contents are no longer synchronized compared to control. WB:WBPerson2021 WB:WBPerson557 Animals contain body regions that are more narrow or drawn together than adjacent body regions. C_elegans_phenotype_ontology WBPhenotype:0000212 body constriction Animals contain body regions that are more narrow or drawn together than adjacent body regions. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of a zygote from formation (gamete fusion) to just prior to the first cell division compared to control. zygotic development abnormal C_elegans_phenotype_ontology WBPhenotype:0000213 zygotic development variant Variations in the progression of a zygote from formation (gamete fusion) to just prior to the first cell division compared to control. WB:WBPerson2021 WB:WBPerson557 Animals respond to alpha amanitin at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000214 alpha amanitin hypersensitive Animals respond to alpha amanitin at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals lack all germline progenitor cells, thereby resulting in the complete absence of a germline. no germline C_elegans_phenotype_ontology WBPhenotype:0000215 no germ line Animals lack all germline progenitor cells, thereby resulting in the complete absence of a germline. WB:WBPaper00001477 WB:WBPerson2021 Any variation in the processes that govern acquisition of particular cell fates compared to control animals. cell fate specification abnormal C_elegans_phenotype_ontology WBPhenotype:0000216 cell fate specification variant Any variation in the processes that govern acquisition of particular cell fates compared to control animals. WB:kmva The time in which a muscle contraction event that controls feeding is increased compared to control. Contractions of the pharynx are necessary for bacterial uptake from the surrounding environment. C_elegans_phenotype_ontology WBPhenotype:0000217 prolonged pharyngeal contraction The time in which a muscle contraction event that controls feeding is increased compared to control. Contractions of the pharynx are necessary for bacterial uptake from the surrounding environment. WB:WBPerson2021 WB:WBPerson557 An excess number of vulval precursor cells receive an inductive signal leading to an increased number of VPCs adopting vulval fates compared to control animals. Hin overinduced C_elegans_phenotype_ontology WBPhenotype:0000218 vulval cell induction increased An excess number of vulval precursor cells receive an inductive signal leading to an increased number of VPCs adopting vulval fates compared to control animals. WB:WBPerson2021 Vulval precursor cells receive a decrease in inductive signal leading to fewer VPCs adopting vulval fates compared to control animals. underinduced C_elegans_phenotype_ontology WBPhenotype:0000219 vulval cell induction reduced Vulval precursor cells receive a decrease in inductive signal leading to fewer VPCs adopting vulval fates compared to control animals. WB:WBPerson2021 Any aberrancy in the processes that govern acquisition of vulval cell fates compared to control animals. vulva cell fate specification abnormal C_elegans_phenotype_ontology WBPhenotype:0000220 vulva cell fate specification variant Any aberrancy in the processes that govern acquisition of vulval cell fates compared to control animals. WB:WBPerson2021 Animals exhibit variations in any chemical reaction or pathway involving neurotransmitters compared to control animals. Neurotransmitters are any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. neurotransmitter metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000221 neurotransmitter metabolism variant Animals exhibit variations in any chemical reaction or pathway involving neurotransmitters compared to control animals. Neurotransmitters are any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. GO:0042133 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any chemical reaction or pathway involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter, compared to control. serotonin metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000222 serotonin metabolism variant Animals exhibit variations in any chemical reaction or pathway involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter, compared to control. GO:0042428 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any chemical reaction or pathway involving acetylcholine, compared to control. Acetylcholine is the acetic acid ester of the organic base choline. acetylcholine metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000223 acetylcholine metabolism variant Animals exhibit variations in any chemical reaction or pathway involving acetylcholine, compared to control. Acetylcholine is the acetic acid ester of the organic base choline. GO:0008291 WB:WBPerson557 WB:WBPerson712 Animals do not contain or are unable to maintain a perceivable level of serotonin capable of initiating or maintaining serotonin-dependent cell activity. C_elegans_phenotype_ontology WBPhenotype:0000224 serotonin deficient Animals do not contain or are unable to maintain a perceivable level of serotonin capable of initiating or maintaining serotonin-dependent cell activity. WB:WBPerson712 Animals are unable to carry out the chemical reactions and pathways resulting in the formation of serotonin. C_elegans_phenotype_ontology WBPhenotype:0000225 serotonin synthesis defective Animals are unable to carry out the chemical reactions and pathways resulting in the formation of serotonin. GO:0042427 WB:WBPerson557 WB:WBPerson712 Animals are unable to carry out any chemical reaction or pathway resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter. C_elegans_phenotype_ontology WBPhenotype:0000226 serotonin catabolism defective Animals are unable to carry out any chemical reaction or pathway resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter. GO:0042429 WB:WBPerson557 WB:WBPerson712 The inability of a male to properly turn during mating behavior. In C. elegans, males typically turn via a sharp ventral arch of the tail, as he approaches either the hermaphrodite head or tail. male turning abnormal C_elegans_phenotype_ontology WBPhenotype:0000227 male turning defective The inability of a male to properly turn during mating behavior. In C. elegans, males typically turn via a sharp ventral arch of the tail, as he approaches either the hermaphrodite head or tail. GO:0034607 WB:WBPaper00000392 WB:WBPaper00002109 Animals accumulate a greater number of genetic lesions than control animals in the absence of an externally controlled mutagen. In C. elegans, this is often measured by observing the number of reversion events of a known mutant gene function over a couple generations. C_elegans_phenotype_ontology WBPhenotype:0000228 spontaneous mutation rate increased Animals accumulate a greater number of genetic lesions than control animals in the absence of an externally controlled mutagen. In C. elegans, this is often measured by observing the number of reversion events of a known mutant gene function over a couple generations. WB:WBPaper00000565 WB:WBPerson712 Animals are shorter and thinner than control animals at the same developmental stage. body size reduced C_elegans_phenotype_ontology Sma WBPhenotype:0000229 small Animals are shorter and thinner than control animals at the same developmental stage. WB:cab WB:cgc31 The girth of the region posterior to the vulva is reduced compared to that anterior to the vulva (the Wit phenotype). In C. elegans this phenotype is associated with anteriorward misplacement of the CAN neurons. C_elegans_phenotype_ontology Wit WBPhenotype:0000230 tail withered The girth of the region posterior to the vulva is reduced compared to that anterior to the vulva (the Wit phenotype). In C. elegans this phenotype is associated with anteriorward misplacement of the CAN neurons. WB:WBPaper00002795 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the physical dimensions of its body compared to control animals of the same developmental stage. body size abnormal C_elegans_phenotype_ontology WBPhenotype:0000231 PATO:0000117. body size variant Animals exhibit variations in the physical dimensions of its body compared to control animals of the same developmental stage. WB:WBPerson712 Variation in the migration pattern of CAN neurons. In C. elegans, CAN neurons move posteriorly from their birthplace in the head to positions near the middle of the embryo. CAN cell migration abnormal C_elegans_phenotype_ontology WBPhenotype:0000232 CAN cell migration variant Variation in the migration pattern of CAN neurons. In C. elegans, CAN neurons move posteriorly from their birthplace in the head to positions near the middle of the embryo. WB:WBPaper00002795 WB:WBPerson2021 Animals exhibit variations in any chemical reaction or pathway involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline, compared to control. dopamine metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000233 dopamine metabolism variant Animals exhibit variations in any chemical reaction or pathway involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline, compared to control. GO:0042417 WB:WBPerson557 WB:WBPerson712 Animals do not contain or are unable to maintain a the level of dopamine capable of initiating or maintaining dopamine-dependent cell activity compared to control animals. C_elegans_phenotype_ontology dopamine levels decreased WBPhenotype:0000234 dopamine deficient Animals do not contain or are unable to maintain a the level of dopamine capable of initiating or maintaining dopamine-dependent cell activity compared to control animals. WB:WBPerson712 Animals are unable to carry out the chemical reactions and pathways resulting in the formation of dopamine. C_elegans_phenotype_ontology WBPhenotype:0000235 dopamine synthesis defective Animals are unable to carry out the chemical reactions and pathways resulting in the formation of dopamine. GO:0042416 WB:WBPerson557 WB:WBPerson712 Animals are unable to carry outany chemical reaction or pathway resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. C_elegans_phenotype_ontology WBPhenotype:0000236 dopamine catabolism defective Animals are unable to carry outany chemical reaction or pathway resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. GO:0042420 WB:WBPerson557 WB:WBPerson712 Animals extend intensity of roaming and or dwelling activity compared to control animals. In C. elegans, hyperactivity may include an increase in nose-lifts per minute. C_elegans_phenotype_ontology WBPhenotype:0000237 foraging hyperactive Animals extend intensity of roaming and or dwelling activity compared to control animals. In C. elegans, hyperactivity may include an increase in nose-lifts per minute. WB:WBPaper00031455 WB:WBPaper00031570 WB:WBPerson712 Animals decrease intensity or rate of roaming and or dwelling activity compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000238 foraging reduced Animals decrease intensity or rate of roaming and or dwelling activity compared to control animals. WB:WBPaper00031455 WB:WBPerson712 The descendants of a vulval precursor cell exhibit altered developmental programs compared to their counterparts in control animals. In C. elegans, the VPCs are P3.p-P8.p. vulval cell lineage abnormal C_elegans_phenotype_ontology VPC lineage abnormal WBPhenotype:0000239 vulval cell lineage variant The descendants of a vulval precursor cell exhibit altered developmental programs compared to their counterparts in control animals. In C. elegans, the VPCs are P3.p-P8.p. WB:WBPaper00005610 WB:WBPerson2021 The processes governing the expansion of blast cell populations vary, such that cell populations are decreased compared to control. C_elegans_phenotype_ontology WBPhenotype:0000240 blast cell proliferation reduced The processes governing the expansion of blast cell populations vary, such that cell populations are decreased compared to control. WB:WBPerson2021 Animals exhibit an increase in the quantity of cells that have undergone programmed cell death but have not been engulfed. C_elegans_phenotype_ontology WBPhenotype:0000241 accumulated cell corpses Animals exhibit an increase in the quantity of cells that have undergone programmed cell death but have not been engulfed. WB:WBPerson712 The epidermal cells of the embryo fail to elongate. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm. C_elegans_phenotype_ontology WBPhenotype:0000242 body elongation defective The epidermal cells of the embryo fail to elongate. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm. WB:WBPerson2021 Removal of cell corpses through a dedicated engulfment pathway is defective. C_elegans_phenotype_ontology corpse engulfment defective persistent cell corpses WBPhenotype:0000243 engulfment failure by killer cell Removal of cell corpses through a dedicated engulfment pathway is defective. WB:WBPerson712 Cells fail to complete the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. C_elegans_phenotype_ontology apoptosis block WBPhenotype:0000244 apoptotic arrest Cells fail to complete the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. WB:WBPerson712 Variations in the movement of sex myoblasts compared to control animals. In C. elegans, the larval SM migrate anteriorly to the precise center of the developing hermaphrodite gonad. SM migration abnormal C_elegans_phenotype_ontology WBPhenotype:0000245 SM migration variant Variations in the movement of sex myoblasts compared to control animals. In C. elegans, the larval SM migrate anteriorly to the precise center of the developing hermaphrodite gonad. WB:WBPaper00003627 WB:WBPerson2021 Animals exhibit variation in the time of onset of the defecation motor program significantly greater than that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0000246 defecation cycle variable length Animals exhibit variation in the time of onset of the defecation motor program significantly greater than that observed for control animals. WB:WBPaper00031896 WB:WBPerson712 Failure to execute the characteristic response to sodium as defined by control animals. In C. elegans, sodium is typically an attractant. C_elegans_phenotype_ontology Na chemotaxis defective sodium acetate chemotaxis defective WBPhenotype:0000247 sodium chemotaxis defective Failure to execute the characteristic response to sodium as defined by control animals. In C. elegans, sodium is typically an attractant. WB:cab WB:cgc387 sodium acetate chemotaxis defective WB:WBPerson2021 OBSOLETE. sensory neuroanatomy abnormal C_elegans_phenotype_ontology WBPhenotype:0000248 obsolete sensory neuroanatomy variant true OBSOLETE. WB:WBPerson557 Failure to execute the characteristic avoidance response to solutions of high osmotic strength as defined by control animals. C_elegans_phenotype_ontology WBPhenotype:0000249 osmotic avoidance defective Failure to execute the characteristic avoidance response to solutions of high osmotic strength as defined by control animals. WB:WBPerson2021 WB:cab Animals exhibit variations in any chemical reaction or pathway involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol, compared to control. octopamine metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000250 octopamine metabolism variant Animals exhibit variations in any chemical reaction or pathway involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol, compared to control. GO:0046333 WB:WBPerson557 WB:WBPerson712 Animals do not contain or are unable to maintain a perceivable level of octopamine capable of initiating or maintaining dopamine-dependent cell activity. C_elegans_phenotype_ontology WBPhenotype:0000251 octopamine deficient Animals do not contain or are unable to maintain a perceivable level of octopamine capable of initiating or maintaining dopamine-dependent cell activity. WB:WBPerson712 Animals fail to respond to the concentration of caffeine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000252 caffeine resistant Animals fail to respond to the concentration of caffeine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals exhibit a lack of consistency, regularity, or uniformity while traveling from one location to another. C_elegans_phenotype_ontology movement irregular WBPhenotype:0000253 movement erratic Animals exhibit a lack of consistency, regularity, or uniformity while traveling from one location to another. WB:WBPerson2021 WB:WBPerson557 Failure to execute the characteristic response to chloride. In C. elegans, chloride is typically an attractant. C_elegans_phenotype_ontology Cl chemotaxis defective WBPhenotype:0000254 chloride chemotaxis defective Failure to execute the characteristic response to chloride. In C. elegans, chloride is typically an attractant. WB:cab WB:cgc387 Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid and phasmid sensilla from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. amphid phasmid morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000255 WBbt:0005394, WBbt:0006753. amphid phasmid neuron morphology variant Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid and phasmid sensilla from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. WB:WBPaper00000938 Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. amphid morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000256 WBbt:0005394. amphid neuron morphology variant Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. WB:WBPaper00000938 Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the phasmid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. phasmid morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000257 WBbt:0006753. phasmid neuron morphology variant Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the phasmid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. WB:WBPaper00000938 Variations in the regulated release of substances by a cell compared to control. WBPhenotype:0000723 cellular secretion abnormal cell secretion abnormal C_elegans_phenotype_ontology WBPhenotype:0000258 cell secretion variant Variations in the regulated release of substances by a cell compared to control. GO:0032940 WB:WBPerson2021 Variations in the regulated release of substances by nonneuronal cells that enclose or ensheath the tips of the sensory dendrites compared to control. sheath cell secretion abnormal C_elegans_phenotype_ontology WBPhenotype:0000259 sheath cell secretion variant Variations in the regulated release of substances by nonneuronal cells that enclose or ensheath the tips of the sensory dendrites compared to control. WB:WBPaper00000822 WB:WBPerson2021 The regulated release of materials by sheath cells is disrupted. C_elegans_phenotype_ontology WBPhenotype:0000260 sheath cell secretion failure The regulated release of materials by sheath cells is disrupted. WB:WBPaper00028924 WB:WBPerson2021 Amphid sheath cells lack the ability to secrete vesicles and their contents within the amphid pocket. C_elegans_phenotype_ontology WBPhenotype:0000261 amphid sheath secretion failure Amphid sheath cells lack the ability to secrete vesicles and their contents within the amphid pocket. WB:WBPaper00028924 WB:WBPerson2021 Animals exhibit variations in the structure or composition of the microtubule-based fibrillar bundle (axoneme) that makes up the core of the middle part of the cilium (in a pattern of nine doublet microtubules attached to the membrane and a variable number of smaller singlet microtubules occupying the center). In C. elegans, the axoneme microtubules are arranged in a pattern of nine doublets attached to the membrane with seven smaller singlet microtubules occupying the center. axoneme morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000262 axoneme morphology variant Animals exhibit variations in the structure or composition of the microtubule-based fibrillar bundle (axoneme) that makes up the core of the middle part of the cilium (in a pattern of nine doublet microtubules attached to the membrane and a variable number of smaller singlet microtubules occupying the center). In C. elegans, the axoneme microtubules are arranged in a pattern of nine doublets attached to the membrane with seven smaller singlet microtubules occupying the center. WB:WBPaper00000932 WB:WBPerson557 WB:WBPerson712 The microbule-based fibrillar bundle in the core of the cilium is reduced in length compared to axonemes of similar cells in control animals. C_elegans_phenotype_ontology WBPhenotype:0000263 axoneme short The microbule-based fibrillar bundle in the core of the cilium is reduced in length compared to axonemes of similar cells in control animals. WB:WBPaper00000932 WB:WBPerson557 WB:WBPerson712 Failure to execute the characteristic response to cAMP as defined by control animals. In C. elegans, cAMP is typically an attractant. C_elegans_phenotype_ontology WBPhenotype:0000264 cAMP chemotaxis defective Failure to execute the characteristic response to cAMP as defined by control animals. In C. elegans, cAMP is typically an attractant. WB:WBPaper00001481 WB:WBPaper00002033 WB:cab WB:cgc387 Movement towards typically attractive volatile organic chemicals is altered as defined by control animals. In C. elegans, these odorants are typically sensed by the AWA and AWC neurons. odorant positive chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0000265 odorant positive chemotaxis variant Movement towards typically attractive volatile organic chemicals is altered as defined by control animals. In C. elegans, these odorants are typically sensed by the AWA and AWC neurons. WB:WBPerson2021 WB:cab WB:cgc1786 Variations that disrupt stereotypical cleavage patterns (such as cleavage rate, division axes or asymmetric division) compared to control. cell cleavage abnormal C_elegans_phenotype_ontology WBPhenotype:0000266 cell cleavage variant Variations that disrupt stereotypical cleavage patterns (such as cleavage rate, division axes or asymmetric division) compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation that causes a delay in the stereotypical cleavage event compared to control. C_elegans_phenotype_ontology WBPhenotype:0000267 cell cleavage delayed Any variation that causes a delay in the stereotypical cleavage event compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation that causes a delay in the stereotypical cleavage pattern of the P cell compared to control. C_elegans_phenotype_ontology WBPhenotype:0000268 P cell cleavage delayed Any variation that causes a delay in the stereotypical cleavage pattern of the P cell compared to control. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. Animals display a phenotype that has not yet been assigned to a current classification. C_elegans_phenotype_ontology WBPhenotype:0000269 obsolete unclassified true OBSOLETE. Animals display a phenotype that has not yet been assigned to a current classification. WB:WBPerson2021 WB:WBPerson557 Seemingly unrelated variations that concurrently occur during early embryonic development compared to control animals. In C. elegans, this can include multiple pronuclei, aberrant cytoplasmic texture, decrease in overall pace of development and osmotic sensitivity. Emb C_elegans_phenotype_ontology WBPhenotype:0000270 pleiotropic defects severe early emb Seemingly unrelated variations that concurrently occur during early embryonic development compared to control animals. In C. elegans, this can include multiple pronuclei, aberrant cytoplasmic texture, decrease in overall pace of development and osmotic sensitivity. WB:cab WB:cgc7141 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000271 obsolete cell cycle slow true The rate of the intrinsic behavioral program that serves to move fertilized eggs down the uterus, through the vulva, and out of the worm onto the substrate does not conform to the pattern observed in control animals (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000272 egg laying irregular The rate of the intrinsic behavioral program that serves to move fertilized eggs down the uterus, through the vulva, and out of the worm onto the substrate does not conform to the pattern observed in control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The number of body thrashes within an aqueous environment in a given period of time are reduced compared with control worms. C_elegans_phenotype_ontology WBPhenotype:0000273 thrashing reduced The number of body thrashes within an aqueous environment in a given period of time are reduced compared with control worms. WB:cab WB:cgc7388 Animals lay eggs that are inviable. C_elegans_phenotype_ontology WBPhenotype:0000274 dead eggs laid Animals lay eggs that are inviable. WB:cab Organisms respond to UV at a lower dose or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000275 organism UV hypersensitive Organisms respond to UV at a lower dose or a shorter exposure compared to control animals. WB:WBPerson557 Animals exhibit variations in their response to X-ray radiation compared to that observed in control animals. organism X ray response abnormal C_elegans_phenotype_ontology WBPhenotype:0000276 organism X ray response variant Animals exhibit variations in their response to X-ray radiation compared to that observed in control animals. WB:WBPerson557 The timing of a biological cycle that recurs with regularity is delayed compared to control. C_elegans_phenotype_ontology WBPhenotype:0000277 rhythm slow The timing of a biological cycle that recurs with regularity is delayed compared to control. GO:0048511 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency or translucency of a particular body region. body region pigmentation abnormal body region pigmentation variant C_elegans_phenotype_ontology WBPhenotype:0000278 body region pigmentation phenotype Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency or translucency of a particular body region. WB:WBPerson557 Males exhibit defects in the insertion of the male copulatory spicules into the mating partner. In C. elegan spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva. C_elegans_phenotype_ontology WBPhenotype:0000279 spicule insertion defective Males exhibit defects in the insertion of the male copulatory spicules into the mating partner. In C. elegan spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva. GO:0034609 WB:WBPerson2021 WB:WBPerson557 The small linear ridges running along the lateral lines of the cuticle, lengthwise along the body, contain gaps as opposed to a continuous arrangement (Wormatlas). gapped alae C_elegans_phenotype_ontology WBPhenotype:0000280 breaks in alae The small linear ridges running along the lateral lines of the cuticle, lengthwise along the body, contain gaps as opposed to a continuous arrangement (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the progression of the muscles of the adult male reproductive system over time form their initial formation to their mature structure compared to control. male sex muscle development abnormal C_elegans_phenotype_ontology WBPhenotype:0000281 male sex muscle development variant Variations in the progression of the muscles of the adult male reproductive system over time form their initial formation to their mature structure compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of the muscles of the adult hermaphrodite reproductive system over time form their initial formation to their mature structure compared to control. hermaphrodite sex muscle development abnormal C_elegans_phenotype_ontology WBPhenotype:0000282 hermaphrodite sex muscle development variant Variations in the progression of the muscles of the adult hermaphrodite reproductive system over time form their initial formation to their mature structure compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit defects in the continuity of lumen between the vulva and uterus compared to control animals. AC block C_elegans_phenotype_ontology WBPhenotype:0000283 vulva uterus connection defective Animals exhibit defects in the continuity of lumen between the vulva and uterus compared to control animals. WB:WBPaper00003386 WB:WBPaper00006298 WB:WBPaper00027236 WB:WBPaper00027316 WB:WBPerson712 Any defect in the process whereby a male inseminates his partner by introducing sperm into the genital tract. C_elegans_phenotype_ontology WBPhenotype:0000284 sperm transfer defective Any defect in the process whereby a male inseminates his partner by introducing sperm into the genital tract. GO:0007320 WB:WBPerson2021 WB:WBPerson557 The extreme ends of any of the finger-like sensory sensilla that project from the tail and embed in the male fan appear bloated or distended. C_elegans_phenotype_ontology WBPhenotype:0000285 ray tips swollen The extreme ends of any of the finger-like sensory sensilla that project from the tail and embed in the male fan appear bloated or distended. WB:WBPerson2021 WB:WBPerson557 Embryos fail to be organized in the same manner as observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000286 embryo disorganized Embryos fail to be organized in the same manner as observed in control animals. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000287 obsolete vulval invagination L4 abnormal true Variations in the progression of the lineages that gives rise to all germ cells, lying in the region adjacent to the proximal gonad (on the side furthest from the founder cells of the somatic gonad), over time compared to control animals. distal germline abnormal C_elegans_phenotype_ontology distal germ line abnormal WBPhenotype:0000288 distal germline variant Variations in the progression of the lineages that gives rise to all germ cells, lying in the region adjacent to the proximal gonad (on the side furthest from the founder cells of the somatic gonad), over time compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the form, structure or composition of the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca compared to control (Wormatlas). uterus morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000289 uterus morphology variant Any variation in the form, structure or composition of the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals lack fully specialized male gametes that are competent for fertilization. C_elegans_phenotype_ontology no sperm WBPhenotype:0000290 sperm absent Animals lack fully specialized male gametes that are competent for fertilization. WB:WBPerson2021 Hermaphrodites lack fully specialized female gametes that are competent for fertilization. C_elegans_phenotype_ontology oocytes absent WBPhenotype:0000291 no oocytes Hermaphrodites lack fully specialized female gametes that are competent for fertilization. WB:WBPerson2021 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a organ system. organ system pigmentation abnormal organ system pigmentation variant C_elegans_phenotype_ontology WBPhenotype:0000292 organ system pigmentation phenotype Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a organ system. WB:WBPerson557 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the alimentary system. alimentary system pigmentation abnormal C_elegans_phenotype_ontology WBPhenotype:0000293 alimentary system pigmentation variant Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the alimentary system. WB:WBPerson557 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that decrease the transparency/translucency of the intestine. Din C_elegans_phenotype_ontology WBPhenotype:0000294 intestine dark Animals exhibit variations in the accumulation or expression of biochromes or any other substances that decrease the transparency/translucency of the intestine. WB:WBPerson557 Animals are able to survive for longer periods at temperatures above standard culture temperatures than control animals. intrinsic thermotolerance increased C_elegans_phenotype_ontology WBPhenotype:0000295 thermotolerance increased Animals are able to survive for longer periods at temperatures above standard culture temperatures than control animals. WB:WBPaper00005836 WB:WBPerson712 The elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) are deformed. In C. elegans males there are two copulatory spicules. C_elegans_phenotype_ontology WBPhenotype:0000296 spicules crumpled The elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) are deformed. In C. elegans males there are two copulatory spicules. WB:WBPerson2021 WB:WBPerson557 Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are joined to one another. WBPhenotype:0001241 ray fusion C_elegans_phenotype_ontology WBPhenotype:0000297 rays fused Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are joined to one another. WB:WBPerson2021 WB:WBPerson557 Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are shifted from their customary place. C_elegans_phenotype_ontology WBPhenotype:0000298 rays displaced Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are shifted from their customary place. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in control animals. sensillum morphology abnormal C_elegans_phenotype_ontology chemosensory cell morphology abnormal WBPhenotype:0000299 sensillum morphology variant Animals exhibit variations in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in control animals. WB:WBPaper00000214 WB:WBPaper00000938 WB:WBPerson712 Animals exhibit variations in the structure or composition of the amphid sensillum cell that ensheathes the dendrite tips of channel neurons and wing cell dedritic processes, from that observed in control animals. Sheath cells in C.elegans have highly invaginated and vesiculated surfaces, which provide a specialized environment for the dendritic structures. amphid sheath cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000300 amphid sheath cell morphology variant Animals exhibit variations in the structure or composition of the amphid sensillum cell that ensheathes the dendrite tips of channel neurons and wing cell dedritic processes, from that observed in control animals. Sheath cells in C.elegans have highly invaginated and vesiculated surfaces, which provide a specialized environment for the dendritic structures. WB:WBPaper00000214 WB:WBPaper00000503 WB:WBPaper00000822 WB:WBPerson712 A migrating distal tip cell (DTC) fails to follow the stereotypical path. In C. elegans this path is U-shaped and results in the formation of reflexed gonadal arm. C_elegans_phenotype_ontology WBPhenotype:0000301 distal tip cell reflex failure A migrating distal tip cell (DTC) fails to follow the stereotypical path. In C. elegans this path is U-shaped and results in the formation of reflexed gonadal arm. WB:WBPaper00029151 WB:WBPerson2021 Failure to execute the characteristic response to benzaldehyde as defined by control animals. In C.elegans benzaldehyde is typically attractive. C_elegans_phenotype_ontology WBPhenotype:0000302 benzaldehyde chemotaxis defective Failure to execute the characteristic response to benzaldehyde as defined by control animals. In C.elegans benzaldehyde is typically attractive. WB:WBPaper00001786 Failure to execute the characteristic response to diacetyl as defined by control animals. In C.elegans diacetyl is typically attractive. C_elegans_phenotype_ontology WBPhenotype:0000303 diacetyl chemotaxis defective Failure to execute the characteristic response to diacetyl as defined by control animals. In C.elegans diacetyl is typically attractive. WB:WBPaper00001786 Failure to execute the characteristic response to isoamyl alcohol as defined by control animals. In C.elegans isoamyl alcohol is typically attractive. C_elegans_phenotype_ontology WBPhenotype:0000304 isoamyl alcohol chemotaxis defective Failure to execute the characteristic response to isoamyl alcohol as defined by control animals. In C.elegans isoamyl alcohol is typically attractive. WB:cab WB:cgc1786 Animals exhibit variations in any of a series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal that influences behavior in control animals. pheromone sensation abnormal C_elegans_phenotype_ontology WBPhenotype:0000305 pheromone sensation variant Animals exhibit variations in any of a series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal that influences behavior in control animals. GO:0043695 WB:WBPerson2021 WB:WBPerson557 Any variation in the characteristic expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to control animals. transgene expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000306 transgene expression variant Any variation in the characteristic expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to control animals. WB:WBPerson557 Animals fail to detect a pheromone stimulus that induces dauer formation in control animals. C_elegans_phenotype_ontology WBPhenotype:0000307 dauer pheromone sensation defective Animals fail to detect a pheromone stimulus that induces dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the processes that govern development of the dauer larva, a developmentally arrested, larval stage that is specialized for survival under harsh, or otherwise unfavorable, environmental conditions. In C. elegans this is an alternative third larval stage. WBPhenotype:0000159 dauer development abnormal dauer development variant C_elegans_phenotype_ontology dauer arrest abnormal dauer arrest variant diapause variant WBPhenotype:0000308 dauer development phenotype Any variation in the processes that govern development of the dauer larva, a developmentally arrested, larval stage that is specialized for survival under harsh, or otherwise unfavorable, environmental conditions. In C. elegans this is an alternative third larval stage. WB:kmva Any variation that decreases the ability of dauer larva to tolerate the exposure to sodium dodecyl sulfate (a detergent) compared to control. C_elegans_phenotype_ontology WBPhenotype:0000309 SDS sensitive dauer Any variation that decreases the ability of dauer larva to tolerate the exposure to sodium dodecyl sulfate (a detergent) compared to control. WB:WBPerson2021 Neurons lack the finger-like dendritic projections, which are observed extending from similar cells in control animals. C_elegans_phenotype_ontology WBPhenotype:0000310 cilia absent Neurons lack the finger-like dendritic projections, which are observed extending from similar cells in control animals. WB:WBPaper00000932 WB:WBPerson712 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000311 obsolete semi sterile true Animals are incapable of synthesizing pheromones that induce dauer formation in control animals. C_elegans_phenotype_ontology WBPhenotype:0000312 dauer pheromone production defective Animals are incapable of synthesizing pheromones that induce dauer formation in control animals. GO:0042446 WB:WBPerson2021 Developing oocytes show defects in their initial entry or progression through the meiotic pathway (such as failure to exit diakinesis). meiotic progression during oogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0000313 meiotic progression during oogenesis variant Developing oocytes show defects in their initial entry or progression through the meiotic pathway (such as failure to exit diakinesis). WB:WBPaper00026997 WB:WBPerson2021 Animals are slight or meager in body size compared to control animals at the same developmental stage. C_elegans_phenotype_ontology WBPhenotype:0000314 scrawny Animals are slight or meager in body size compared to control animals at the same developmental stage. WB:WBPerson2021 WB:WBPerson557 Any variation with respect to perception or response to mechanical stimuli compared to control animals. WBPhenotype:0000513 Mec touch response abnormal mechanosensation abnormal C_elegans_phenotype_ontology WBPhenotype:0000315 mechanosensation variant Any variation with respect to perception or response to mechanical stimuli compared to control animals. WB:cab Failure to execute a characteristic response when struck or stroked in the posterior region. In C. elegans, animals move forward movement when struck or stroked in the posterior region, usually with a hair or similar fiber. The posterior region lies between the vulva and the tail. touch resistant posterior body C_elegans_phenotype_ontology touch insensitive tail WBPhenotype:0000316 touch resistant tail Failure to execute a characteristic response when struck or stroked in the posterior region. In C. elegans, animals move forward movement when struck or stroked in the posterior region, usually with a hair or similar fiber. The posterior region lies between the vulva and the tail. WB:WBPaper00000502 WB:WBPaper00001133 WB:WBPaper00001705 WB:WBPerson557 Animals are deficient in the foraging response in which an animal quickly pulls its head away from a stimulus to the nose (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000317 head withdrawal defective Animals are deficient in the foraging response in which an animal quickly pulls its head away from a stimulus to the nose (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Cells of the animals proceed through their replicative phase at a pace slower than observed for control cells. C_elegans_phenotype_ontology WBPhenotype:0000318 cell cycle delayed Cells of the animals proceed through their replicative phase at a pace slower than observed for control cells. WB:WBPerson712 Animals have increased girth and increased length compared to control animals at the same developmental stage. body size enlarged C_elegans_phenotype_ontology WBPhenotype:0000319 large Animals have increased girth and increased length compared to control animals at the same developmental stage. WB:WBPerson2021 WB:WBPerson557 Animals show a decrease in survivorship after thawing compared to control. C_elegans_phenotype_ontology WBPhenotype:0000320 reduced viability after freezing Animals show a decrease in survivorship after thawing compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of any portion of the extreme anterior part of their body compared to control. nose morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000321 nose morphology variant Animals exhibit variations in the form, structure or composition of any portion of the extreme anterior part of their body compared to control. WB:WBPerson2021 WB:WBPerson557 The extreme anterior part of the body appears blunted in shape. C_elegans_phenotype_ontology WBPhenotype:0000322 nose rounded The extreme anterior part of the body appears blunted in shape. WB:WBPerson2021 WB:WBPerson557 The most anterior portion of the animal appears bloated or distended. C_elegans_phenotype_ontology WBPhenotype:0000323 head swollen The most anterior portion of the animal appears bloated or distended. WB:WBPerson2021 WB:WBPerson557 Animals exhibit a decreased body length compared to control animals of the same developmental stage. C_elegans_phenotype_ontology WBPhenotype:0000324 short Animals exhibit a decreased body length compared to control animals of the same developmental stage. WB:WBPerson712 Animals respond to arecoline at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000325 arecoline hypersensitive Animals respond to arecoline at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of arecoline that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000326 arecoline resistant Animals fail to respond to the concentration of arecoline that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Any defect in the muscle contractions of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000327 corpus contraction defect Any defect in the muscle contractions of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the rhythmic contractions of the posterior pharynx (terminal bulb), such as timing, strength etc. In C. elegans contraction of the terminal bulb inverts the grinder, allowing bacteria in front of the grinder to be broken up and transported to the intestine. terminal bulb contraction abnormal C_elegans_phenotype_ontology WBPhenotype:0000328 terminal bulb contraction variant Variations in the rhythmic contractions of the posterior pharynx (terminal bulb), such as timing, strength etc. In C. elegans contraction of the terminal bulb inverts the grinder, allowing bacteria in front of the grinder to be broken up and transported to the intestine. WB:WBPaper00001696 The rhythmic contractions of pharyngeal compartments are no longer synchronized compared to control. In C. elegans the corpus and terminal bulb normally contract simultaneously. C_elegans_phenotype_ontology WBPhenotype:0000329 pumping asynchronous The rhythmic contractions of pharyngeal compartments are no longer synchronized compared to control. In C. elegans the corpus and terminal bulb normally contract simultaneously. WB:WBPaper00001696 Defects in rhythmic pharyngeal relaxations compared to control animals. In C. elegans pharyngeal relaxation follows a contraction event and facilitates bacterial trapping within the pharynx while expelling liquid. C_elegans_phenotype_ontology WBPhenotype:0000330 pharyngeal relaxation defective Defects in rhythmic pharyngeal relaxations compared to control animals. In C. elegans pharyngeal relaxation follows a contraction event and facilitates bacterial trapping within the pharynx while expelling liquid. WB:WBPaper00001709 Animals fail to respond to the concentration of sodium potassium ATPase antagonists that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. ouabain resistant C_elegans_phenotype_ontology WBPhenotype:0000331 inhibitors of na k atpase resistant Animals fail to respond to the concentration of sodium potassium ATPase antagonists that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson2021 Animals respond to inhibitors of sodium potassium ATPase at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000332 inhibitors of sodium potassium ATPase hypersensitive Animals respond to inhibitors of sodium potassium ATPase at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 The time interval of the stereotyped sequence of muscle contractions by individual pharyngeal muscles that act to draw food into the pharynx is shorter compared to that observed in control (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000333 pharyngeal pumps brief The time interval of the stereotyped sequence of muscle contractions by individual pharyngeal muscles that act to draw food into the pharynx is shorter compared to that observed in control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Failure of muscle contractions in the corpus and isthmus to trap and transport bacteria posteriorly in the pharynx. C_elegans_phenotype_ontology WBPhenotype:0000334 isthmus corpus slippery Failure of muscle contractions in the corpus and isthmus to trap and transport bacteria posteriorly in the pharynx. WB:WBPaper00001696 Failure of pharyngeal contractions to trap and transport bacteria posteriorly. In C. elegans this defect results in a distention of the pharyngeal lumen. C_elegans_phenotype_ontology WBPhenotype:0000335 pharynx slippery Failure of pharyngeal contractions to trap and transport bacteria posteriorly. In C. elegans this defect results in a distention of the pharyngeal lumen. WB:WBPaper00001696 Variations in the rhythmic relaxations of the posterior pharynx (terminal bulb). In C. elegans the relaxation of the terminal bulb returns the grinder to its relaxed forward position. terminal bulb relaxation abnormal C_elegans_phenotype_ontology WBPhenotype:0000336 terminal bulb relaxation variant Variations in the rhythmic relaxations of the posterior pharynx (terminal bulb). In C. elegans the relaxation of the terminal bulb returns the grinder to its relaxed forward position. WB:WBPaper00001696 Failure of the grinder to come to a full relaxed position between pumps compared to control. C_elegans_phenotype_ontology WBPhenotype:0000337 grinder relaxation defective Failure of the grinder to come to a full relaxed position between pumps compared to control. WB:WBPaper00001709 Swelling in the post anal region compared to control. In C. elegans this swelling can be associated with infection from the nematode-specific bacterial pathogen, Microbacterium nematophilum. Dar C_elegans_phenotype_ontology deformed anal region WBPhenotype:0000338 tail swelling Swelling in the post anal region compared to control. In C. elegans this swelling can be associated with infection from the nematode-specific bacterial pathogen, Microbacterium nematophilum. WB:WBPaper00026735 WB:cab Worms sporatically appear turgid or swollen as a result of an excess number of eggs being retained in the uterus. C_elegans_phenotype_ontology WBPhenotype:0000339 transient bloating Worms sporatically appear turgid or swollen as a result of an excess number of eggs being retained in the uterus. WB:WBPerson2021 WB:WBPerson557 Animals fail to respond to the concentration of imipramine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000340 imipramine resistant Animals fail to respond to the concentration of imipramine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals respond to imipramine at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000341 imipramine hypersensitive Animals respond to imipramine at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Any variation in the form, structure or composition of the adult male tail including the lateral fan and rays compared to control. bursa morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000342 bursa morphology variant Any variation in the form, structure or composition of the adult male tail including the lateral fan and rays compared to control. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000343 obsolete cloaca morphology abnormal true Any of the contents that comprise the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus extend into the external environment through the cloacal opening. C_elegans_phenotype_ontology WBPhenotype:0000344 cloacal structures protrude Any of the contents that comprise the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus extend into the external environment through the cloacal opening. WB:WBPerson2021 WB:WBPerson557 Any variation that alters the physical partitioning and separation of a vulval precursor cell into daughter cells compared to control. VPC cell division abnormal C_elegans_phenotype_ontology WBPhenotype:0000345 VPC cell division variant Any variation that alters the physical partitioning and separation of a vulval precursor cell into daughter cells compared to control. WB:WBPerson2021 WB:WBPerson557 Adult animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals. adult pigmentation abnormal C_elegans_phenotype_ontology WBPhenotype:0000346 adult pigmentation variant Adult animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals. WB:WBPerson557 Any variation in the progression of the cuticle-lined sinus opening on the posterior ventral surface of the animal over time from its formation to its mature structure compared to control (Wormatlas). The function of the rectum is to excrete waste products from the alimentary system. rectal development abnormal C_elegans_phenotype_ontology WBPhenotype:0000347 rectal development variant Any variation in the progression of the cuticle-lined sinus opening on the posterior ventral surface of the animal over time from its formation to its mature structure compared to control (Wormatlas). The function of the rectum is to excrete waste products from the alimentary system. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000348 obsolete muscle activation defective true A semi-paralysed body phenotype in which muscle tone is lost and the animal fails to actively control its body shape (Wormatlas). C_elegans_phenotype_ontology floppy limp WBPhenotype:0000349 flaccid A semi-paralysed body phenotype in which muscle tone is lost and the animal fails to actively control its body shape (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the structure or appearance of the thin cuticle specialization found at the extreme posterior end of the hermaphrodite tail compared to control. C_elegans_phenotype_ontology WBPhenotype:0000350 hermaphrodite tail spike variant Any variation in the structure or appearance of the thin cuticle specialization found at the extreme posterior end of the hermaphrodite tail compared to control. WB:WBPerson2021 WB:WBPerson557 Animals fail to emerge from an egg shell. C_elegans_phenotype_ontology WBPhenotype:0000351 failure to hatch Animals fail to emerge from an egg shell. GO:0035188 WB:WBPerson2021 Backward movement is not coordinated as in control. This often causes jerky or spastic backward locomotion. C_elegans_phenotype_ontology WBPhenotype:0000352 backing uncoordinated Backward movement is not coordinated as in control. This often causes jerky or spastic backward locomotion. WB:WBPaper00001709 Animals spend more time backing compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000353 backing increased Animals spend more time backing compared to control animals. WB:cab Variations in the processes leading to the specialization of cell. Differentiation impacts diverse cellular properties such as size, shape, polarity, gene expression and responsiveness to signals/cues. cell differentiation abnormal C_elegans_phenotype_ontology WBPhenotype:0000354 cell differentiation variant Variations in the processes leading to the specialization of cell. Differentiation impacts diverse cellular properties such as size, shape, polarity, gene expression and responsiveness to signals/cues. WB:WBPerson2021 Specialization of HSN precursor cells to mature HSN neurons occurs at an earlier stage of development compared to control. C_elegans_phenotype_ontology WBPhenotype:0000355 HSN differentiation precocious Specialization of HSN precursor cells to mature HSN neurons occurs at an earlier stage of development compared to control. WB:WBPerson2021 The progression of immature germ cells to functional sperm is retarded compared to control. C_elegans_phenotype_ontology WBPhenotype:0000356 spermatogenesis delayed The progression of immature germ cells to functional sperm is retarded compared to control. WB:WBPaper00005566 WB:WBPerson2021 Animals lay inactivated oocytes. In C elegans this may be due to perturbations that eliminate spermatogenesis or result in the production of defective sperm. C_elegans_phenotype_ontology WBPhenotype:0000357 unfertilized oocytes laid Animals lay inactivated oocytes. In C elegans this may be due to perturbations that eliminate spermatogenesis or result in the production of defective sperm. WB:WBPaper00001075 WB:WBPerson2021 Animals execute supernumerary cell divisions post-hatching. C_elegans_phenotype_ontology supernumerary cell divisions WBPhenotype:0000358 extra cell division postembryonic Animals execute supernumerary cell divisions post-hatching. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the response to the addition of tunicamycin compared to that observed in control animals. Tunicamycin induces the unfolded protein response. tunicamycin response abnormal C_elegans_phenotype_ontology WBPhenotype:0000359 tunicamycin response variant Animals exhibit variations in the response to the addition of tunicamycin compared to that observed in control animals. Tunicamycin induces the unfolded protein response. WB:WBPaper00030877 WB:WBperson557 The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell is impaired. C_elegans_phenotype_ontology WBPhenotype:0000360 Possible XP. cytoplasmic streaming defective The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell is impaired. GO:0099636 WB:WBPaper00050908 WB:WBPerson2021 WB:WBPerson557 Cessation of development at an intermediate stage in embryogenesis, immediately following the completion of gastrulation. In C. elegans this occurs around 350-390 minutes after first cleavage, cell number is at approximately 560 cells. At this time cell proliferation ceases and the embryo begins morphogenesis and elongation. The shape of the entire embryo within the eggshell resembles a lima bean (Wormatlas). Emb C_elegans_phenotype_ontology arrest during epiboly WBPhenotype:0000361 lima bean arrest Cessation of development at an intermediate stage in embryogenesis, immediately following the completion of gastrulation. In C. elegans this occurs around 350-390 minutes after first cleavage, cell number is at approximately 560 cells. At this time cell proliferation ceases and the embryo begins morphogenesis and elongation. The shape of the entire embryo within the eggshell resembles a lima bean (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the fluid-filled compartment inside the developing embryo at the onset of gastrulation over time from its formation to its mature structure compared to control (Wormatlas). blastocoel abnormal C_elegans_phenotype_ontology WBPhenotype:0000362 blastocoel variant Any variation in the progression of the fluid-filled compartment inside the developing embryo at the onset of gastrulation over time from its formation to its mature structure compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation that delays the physical partitioning and separation of a cell into daughter cells compared to control. C_elegans_phenotype_ontology WBPhenotype:0000363 cell division slow Any variation that delays the physical partitioning and separation of a cell into daughter cells compared to control. WB:WBPerson2021 WB:WBPerson557 The birefringent inclusions typically found in the intestinal cytoplasm accumulate extracellularly in the intestinal lumen. C_elegans_phenotype_ontology WBPhenotype:0000364 gut granule birefringence misplaced The birefringent inclusions typically found in the intestinal cytoplasm accumulate extracellularly in the intestinal lumen. WB:WBPaper00025094 Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing. Emb Eos C_elegans_phenotype_ontology WBPhenotype:0000365 embryo osmotic integrity defective early emb Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing. WB:cab WB:cgc7141 Cessation of development that normally occurs in C. elegans 520-620min after the first cleavage at 20C, the stage between the 2-fold and fully elongated embryo. Emb C_elegans_phenotype_ontology active elongation arrest WBPhenotype:0000366 three fold arrest Cessation of development that normally occurs in C. elegans 520-620min after the first cleavage at 20C, the stage between the 2-fold and fully elongated embryo. WB:WBPerson101 Cessation of development during the middle stage in embryogenesis of the worm in which the embryo is slightly folded within the eggshell (Wormatlas). Emb C_elegans_phenotype_ontology end of epiboly arrest WBPhenotype:0000367 comma arrest emb Cessation of development during the middle stage in embryogenesis of the worm in which the embryo is slightly folded within the eggshell (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Cessation of development that normally occurs in C. elegans 420-460 min after the first embryonic cleavage at 20C, the stage between the comma and 2-fold embryo. Emb C_elegans_phenotype_ontology arrest beginning elongation WBPhenotype:0000368 one point five fold arrest emb Cessation of development that normally occurs in C. elegans 420-460 min after the first embryonic cleavage at 20C, the stage between the comma and 2-fold embryo. WB:WBPerson101 Cessation of development during the final two stages in embryogenesis, 'early pretzel' stage and 'late pretzel' stage, just prior to hatching. The animal now is folded into four lengths within the eggshell and resembles a pretzel. By early pretzel stage, the head begins to move independently from the body (Wormatlas). Emb C_elegans_phenotype_ontology end of elongation arrest WBPhenotype:0000369 pretzel arrest Cessation of development during the final two stages in embryogenesis, 'early pretzel' stage and 'late pretzel' stage, just prior to hatching. The animal now is folded into four lengths within the eggshell and resembles a pretzel. By early pretzel stage, the head begins to move independently from the body (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The fertilized oocytes have a greater than standard length measured end to end compared to control. C_elegans_phenotype_ontology WBPhenotype:0000370 egg long The fertilized oocytes have a greater than standard length measured end to end compared to control. WB:WBPerson2021 WB:WBPerson557 The physical partitioning and separation of a cell into daughter cells is interupted. C_elegans_phenotype_ontology WBPhenotype:0000371 cell division incomplete The physical partitioning and separation of a cell into daughter cells is interupted. WB:WBPerson2021 WB:WBPerson557 Animals lack the two small cells produced, each during one of the two meiotic cell divisions (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000372 no polar body formation Animals lack the two small cells produced, each during one of the two meiotic cell divisions (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The overall structure or appearance of fertilized oocytes that are laid exhibit nonconsistent and significant deviation from that of control animals. C_elegans_phenotype_ontology WBPhenotype:0000373 egg shape variable The overall structure or appearance of fertilized oocytes that are laid exhibit nonconsistent and significant deviation from that of control animals. WB:WBPerson2021 WB:WBPerson557 The time interval in which early embryonic cell divisions occur is increased compared to control. C_elegans_phenotype_ontology WBPhenotype:0000374 early divisions prolonged The time interval in which early embryonic cell divisions occur is increased compared to control. WB:WBPerson2021 WB:WBPerson557 The time interval in which late embryonic cell divisions occur is increased compared to control. C_elegans_phenotype_ontology WBPhenotype:0000375 later divisions prolonged The time interval in which late embryonic cell divisions occur is increased compared to control. WB:WBPerson2021 WB:WBPerson557 Animals lack the inner space of the uterus through which the fertilized egg passes on its way out of the nematode via the vulva (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000376 no uterine cavity Animals lack the inner space of the uterus through which the fertilized egg passes on its way out of the nematode via the vulva (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of the internal space of the excretory canal compared to control animals. canal lumen morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000377 canal lumen morphology variant Animals exhibit variations in the form, structure or composition of the internal space of the excretory canal compared to control animals. WB:WBPerson2021 WB:WBPerson557 Pharyngeal muscle contractions show less displacement than that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000378 pharyngeal pumping shallow Pharyngeal muscle contractions show less displacement than that observed in control animals. WB:WBPerson2021 WB:WBPerson557 The most anterior portion of the animal contains a V-shaped indentation. C_elegans_phenotype_ontology WBPhenotype:0000379 head notched The most anterior portion of the animal contains a V-shaped indentation. WB:WBPaper00000031 The final step of the defecation motor program does not occur at each cycle, but is activated occasionally. During this step in C. elegans specialized enteric muscles contract to expel the contents of the gut through the anus. C_elegans_phenotype_ontology WBPhenotype:0000380 expulsion infrequent The final step of the defecation motor program does not occur at each cycle, but is activated occasionally. During this step in C. elegans specialized enteric muscles contract to expel the contents of the gut through the anus. WB:WBPaper00002315 WB:WBPerson712 Animals fail to respond to the concentration of serotonin reuptake inhibitors that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000381 serotonin reuptake inhibitor resistant Animals fail to respond to the concentration of serotonin reuptake inhibitors that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals respond to serotonin reuptake inhibitors at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000382 serotonin reuptake inhibitor hypersensitive Animals respond to serotonin reuptake inhibitors at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 The de novo synthesis of any lipid species is reduced compared to that observed in control animals. C_elegans_phenotype_ontology lipid synthesis decreased WBPhenotype:0000383 lipid synthesis defective The de novo synthesis of any lipid species is reduced compared to that observed in control animals. WB:WBPerson712 Variations in the cue-directed extension of an axon towards a specific target site compared to control. (Axon guidance often depends on a combination of attractive and repulsive cues). axon guidance abnormal C_elegans_phenotype_ontology axon pathfinding abnormal WBPhenotype:0000384 axon guidance variant Variations in the cue-directed extension of an axon towards a specific target site compared to control. (Axon guidance often depends on a combination of attractive and repulsive cues). GO:0048846 WB:WBPerson2021 Animals produce an increased sperm population compared to control. C_elegans_phenotype_ontology WBPhenotype:0000385 sperm excess Animals produce an increased sperm population compared to control. WB:WBPerson2021 Programmed cell death of germ cells caused by exposure to DNA-damaging chemical agents does not occur to the same extent as it does in control animals. genotoxic induced apoptosis abnormal C_elegans_phenotype_ontology DNA damage induced apoptosis abnormal WBPhenotype:0000386 genotoxic chemical induced apoptosis variant Programmed cell death of germ cells caused by exposure to DNA-damaging chemical agents does not occur to the same extent as it does in control animals. WB:WBPaper00032006 WB:WBPaper00032243 WB:WBPaper00032356 WB:WBPerson712 The mature male gametes lack self-propelled movement. C_elegans_phenotype_ontology WBPhenotype:0000387 sperm nonmotile The mature male gametes lack self-propelled movement. GO:0030317 WB:WBPerson2021 WB:WBPerson557 Any variation in the form, structure or composition of the mature male gamete, which merges with an oocyte to create a fertilized embryo copared to control (Wormatlas). sperm morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000388 sperm morphology variant Any variation in the form, structure or composition of the mature male gamete, which merges with an oocyte to create a fertilized embryo copared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any perturbation that renders hermaphrodite derived sperm incompetent at fertilizing an oocyte. Fer Spe C_elegans_phenotype_ontology WBPhenotype:0000389 hermaphrodite sperm fertilization defective Any perturbation that renders hermaphrodite derived sperm incompetent at fertilizing an oocyte. WB:WBPaper00001075 WB:WBPerson2021 Spermatids fail to mature into active sperm. In C. elegans round sessile spermatids mature into spermatozoa (polarized cells with a motile pseudopod), upon copulation or treatment with proteases. C_elegans_phenotype_ontology spermiogenesis defective WBPhenotype:0000390 spermatid activation defective Spermatids fail to mature into active sperm. In C. elegans round sessile spermatids mature into spermatozoa (polarized cells with a motile pseudopod), upon copulation or treatment with proteases. WB:WBPaper00000884 WB:WBPaper00027300 WB:WBPerson2021 Animals lack one or more of the stereotyped muscle contractions that result in defecation compared to control. In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp). C_elegans_phenotype_ontology WBPhenotype:0000391 defecation missing motor steps Animals lack one or more of the stereotyped muscle contractions that result in defecation compared to control. In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp). WB:WBPerson2021 WB:WBPerson557 Animals exhibit an increase in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine. C_elegans_phenotype_ontology WBPhenotype:0000392 intestinal fluorescence increased Animals exhibit an increase in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine. WB:WBPerson557 Characteristic movement of cells from one site to another is abolished compared to control. C_elegans_phenotype_ontology WBPhenotype:0000393 cell migration failure Characteristic movement of cells from one site to another is abolished compared to control. WB:WBPerson2021 Any variation in the movement of a protein through a gel matrix when an electric field is applied compared to control. C_elegans_phenotype_ontology WBPhenotype:0000394 electrophoretic variant protein Any variation in the movement of a protein through a gel matrix when an electric field is applied compared to control. WB:WBPerson2021 WB:WBPerson557 Animals are agametic (lack mature germ cells). C_elegans_phenotype_ontology WBPhenotype:0000395 no differentiated gametes Animals are agametic (lack mature germ cells). WB:WBPerson2021 Gonadal arms do not bend or curve. In C. elegans gonad arms normally reflex to form a stereotypical U-shaped pattern. C_elegans_phenotype_ontology WBPhenotype:0000396 non reflexed gonad arms Gonadal arms do not bend or curve. In C. elegans gonad arms normally reflex to form a stereotypical U-shaped pattern. WB:WBPaper00005086 WB:WBPaper00029151 WB:WBPerson2021 Animals do not respond to prodding with a fine platinum wire or similar tool compared to controls. C_elegans_phenotype_ontology harsh body touch insensitive WBPhenotype:0000397 harsh body touch resistant Animals do not respond to prodding with a fine platinum wire or similar tool compared to controls. WB:WBPaper00000502 Animals do not respond to stroking to the head or tail with a hair or similar fiber, but does respond to stronger mechanical stimuli such as prodding with a fine platinum wire or similar tool compared to controls. C_elegans_phenotype_ontology light body touch insensitive WBPhenotype:0000398 light body touch resistant Animals do not respond to stroking to the head or tail with a hair or similar fiber, but does respond to stronger mechanical stimuli such as prodding with a fine platinum wire or similar tool compared to controls. WB:WBPaper00000502 Any variation in the progression of the components of the gonad that are separate from the germline proper over time from its formation to its mature structure compared to control (Wormatlas). somatic gonad development abnormal C_elegans_phenotype_ontology WBPhenotype:0000399 somatic gonad development variant Any variation in the progression of the components of the gonad that are separate from the germline proper over time from its formation to its mature structure compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The developmental progression of the set of precursor cells that later give rise to the somatic tissues of the gonadal tract is impaired (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000400 somatic gonad primordium development defective The developmental progression of the set of precursor cells that later give rise to the somatic tissues of the gonadal tract is impaired (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals lack the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000401 no uterus Animals lack the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Lawn avoidance refers to behavior in which animals initially enter the bacterial lawn but later exit and remain near the edge of the bacteria. Lawn avoidance is often a response to bacterial food, that is pathogenic or low quality to the animal. C_elegans_phenotype_ontology WBPhenotype:0000402 avoids bacterial lawn Lawn avoidance refers to behavior in which animals initially enter the bacterial lawn but later exit and remain near the edge of the bacteria. Lawn avoidance is often a response to bacterial food, that is pathogenic or low quality to the animal. WB:WBPaper00029071 WB:WBPerson2021 Any defect in the movement of sperm out of the seminal vesicle and into the vas deferens following tonic insertion of spicules into the mating partner compared to control. C_elegans_phenotype_ontology WBPhenotype:0000403 sperm transfer initiation defective Any defect in the movement of sperm out of the seminal vesicle and into the vas deferens following tonic insertion of spicules into the mating partner compared to control. WB:WBPaper00028400 The emergence of larvae from their protective egg shells is retarded compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000404 delayed hatching The emergence of larvae from their protective egg shells is retarded compared to control animals. GO:0035188 WB:WBPerson2021 The size of haploid female germ cells (oocytes) are significantly larger compared to control. C_elegans_phenotype_ontology oocytes large WBPhenotype:0000405 giant oocytes The size of haploid female germ cells (oocytes) are significantly larger compared to control. WB:WBPerson2021 WB:WBPerson557 Animals have protrusions or bumps on their exterior which are not characteristic of control animals. Lpy C_elegans_phenotype_ontology WBPhenotype:0000406 lumpy Animals have protrusions or bumps on their exterior which are not characteristic of control animals. WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000407 obsolete ray loss true The process through which a dauer larva reverts to normal developmental programs is blocked. C_elegans_phenotype_ontology WBPhenotype:0000408 dauer recovery inhibited The process through which a dauer larva reverts to normal developmental programs is blocked. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of any of its parts at different stages of the lifecycle, compared to control animals. Vab C_elegans_phenotype_ontology WBPhenotype:0000409 organism morphology variable Animals exhibit variations in the form, structure or composition of any of its parts at different stages of the lifecycle, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals lack the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control. C_elegans_phenotype_ontology WBPhenotype:0000410 no defecation cycle Animals lack the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control. WB:WBPerson2021 WB:WBPerson557 Animals die as rigid, rod-like larva. In C. elegans this defect is often caused by the misspecification of the excretory duct cell. Lvl C_elegans_phenotype_ontology Let WBPhenotype:0000411 rod like larval lethal Animals die as rigid, rod-like larva. In C. elegans this defect is often caused by the misspecification of the excretory duct cell. WB:WBPaper00001366 WB:WBPaper00002764 WB:WBPerson2021 Failure to execute the characteristic response to 1-octanol as defined by control animals. In C.elegans 1-octanol is typically a repellant. C_elegans_phenotype_ontology WBPhenotype:0000412 octanol chemotaxis defective Failure to execute the characteristic response to 1-octanol as defined by control animals. In C.elegans 1-octanol is typically a repellant. WB:WBPaper00002314 Pharyngeal muscle is immobilized resulting in lack of pumping or lack of response to external stimulation. C_elegans_phenotype_ontology WBPhenotype:0000413 pharyngeal muscle paralyzed Pharyngeal muscle is immobilized resulting in lack of pumping or lack of response to external stimulation. WB:WBPerson557 WB:cab The cell takes on a different identity from which it was initially committed. C_elegans_phenotype_ontology WBPhenotype:0000414 cell fate transformation The cell takes on a different identity from which it was initially committed. GO:0045165 WB:WBPaper00002924 WB:WBPerson712 Animals exhibit variations in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control. necrotic cell death abnormal C_elegans_phenotype_ontology WBPhenotype:0000415 necrotic cell death variant Animals exhibit variations in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control. GO:0070265 WB:WBPerson712 Variations in the generation of the nutrient protein produced by intestinal cells and secreted by them into the pseudocoelom, from which it can be shared with other tissues in the body compared to control (Wormatlas). yolk synthesis abnormal C_elegans_phenotype_ontology vitellogenin synthesis abnormal WBPhenotype:0000416 yolk synthesis variant Variations in the generation of the nutrient protein produced by intestinal cells and secreted by them into the pseudocoelom, from which it can be shared with other tissues in the body compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The process of physical partitioning and separation of a cell into daughter cells is abolished. C_elegans_phenotype_ontology WBPhenotype:0000417 cell division failure The process of physical partitioning and separation of a cell into daughter cells is abolished. WB:WBPerson2021 WB:WBPerson557 The physical partitioning and separation of an intestinal cell into daughter cells is abolished. C_elegans_phenotype_ontology WBPhenotype:0000418 intestinal cell division failure The physical partitioning and separation of an intestinal cell into daughter cells is abolished. WB:WBPerson2021 WB:WBPerson557 Animals die at the L3 stage of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0000419 L3 lethal Animals die at the L3 stage of the life cycle. WB:WBPerson2021 Animals respond to levamisole at a lower concentration or a shorter exposure compared to control animals. Levamisole is a cholinergic agonist. C_elegans_phenotype_ontology tetramisole hypersensitive WBPhenotype:0000420 levamisole hypersensitive Animals respond to levamisole at a lower concentration or a shorter exposure compared to control animals. Levamisole is a cholinergic agonist. WB:WBPerson557 Animals fail to respond to the concentration of levamisole that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans resistance to levamisole is often assayed via body contraction response, ventral tail curling response etc. Lev R C_elegans_phenotype_ontology tetramisole resistant WBPhenotype:0000421 levamisole resistant Animals fail to respond to the concentration of levamisole that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans resistance to levamisole is often assayed via body contraction response, ventral tail curling response etc. WB:WBPaper00000484 WB:WBPerson2021 Animals exhibit spasmodic muscle twitching superimposed on normal sinusoidal motion. C_elegans_phenotype_ontology WBPhenotype:0000422 twitcher Animals exhibit spasmodic muscle twitching superimposed on normal sinusoidal motion. WB:WBPaper00000484 Any variation in the contractions of the muscles in the most anterior body region of the animal compared to control. head muscle contraction abnormal C_elegans_phenotype_ontology WBPhenotype:0000423 head muscle contraction variant Any variation in the contractions of the muscles in the most anterior body region of the animal compared to control. WB:WBPerson557 Any variation in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals. antibody staining abnormal C_elegans_phenotype_ontology WBPhenotype:0000424 antibody staining variant Any variation in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation that results in a decrease in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000425 antibody staining reduced Any variation that results in a decrease in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation that results in an increase in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000426 antibody staining increased Any variation that results in an increase in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000427 no cuticle Animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Adult animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000428 no adult cuticle Adult animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the specialized structures of the animal which allow the successful transfer of sperm from one organism to another, compared to control. copulatory structure development abnormal C_elegans_phenotype_ontology WBPhenotype:0000429 copulatory structure development variant Any variation in the progression of the specialized structures of the animal which allow the successful transfer of sperm from one organism to another, compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm over time from its formation to its mature structure compared to control (Wormatlas). male copulatory structure development abnormal C_elegans_phenotype_ontology WBPhenotype:0000430 male copulatory structure development variant Any variation in the progression of the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm over time from its formation to its mature structure compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the specialized structures of a hermaphrodite which allow the successful transfer of sperm from a male, compared to control. hermaphrodite copulatory structure development abnormal C_elegans_phenotype_ontology WBPhenotype:0000431 hermaphrodite copulatory structure development variant Any variation in the progression of the specialized structures of a hermaphrodite which allow the successful transfer of sperm from a male, compared to control. WB:WBPerson2021 WB:WBPerson557 Animals lack the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000432 male copulatory structure absent Animals lack the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the processes involving the production of new DNA strands compared to control. DNA synthesis abnormal C_elegans_phenotype_ontology WBPhenotype:0000433 DNA synthesis variant Variations in the processes involving the production of new DNA strands compared to control. GO:0006260 WB:WBPerson2021 The developmental process by which a progressive change in the state of some part of an organism specifically contributing to its ability to form offspring is impaired. C_elegans_phenotype_ontology WBPhenotype:0000434 sexual maturation defective The developmental process by which a progressive change in the state of some part of an organism specifically contributing to its ability to form offspring is impaired. GO:0003006 WB:WBPerson2021 WB:WBPerson557 OBSOLETE. Any change in the subcellular localization of a protein. C_elegans_phenotype_ontology WBPhenotype:0000435 obsolete protein localization abnormal true Any variation in the placement of a protein within in a cell or cellular compartment compared to control. WBPhenotype:0000435 protein localization abnormal protein subcellular localization abnormal C_elegans_phenotype_ontology WBPhenotype:0000436 protein subcellular localization variant Any variation in the placement of a protein within in a cell or cellular compartment compared to control. WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000437 obsolete heterochronic defect true Variations that result in the deceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000438 retarded heterochronic variations Variations that result in the deceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control. GO:0040034 WB:WBPerson2021 WB:WBPerson557 Variations that result in the acceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000439 precocious heterochronic variations Variations that result in the acceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control. GO:0040034 WB:WBPerson2021 WB:WBPerson557 The structure made by the processes of the excretory canal cell is increased in size compared to control. In C. elegans this is an H-shaped structure which extends almost the full length of the body on both sides of the animal, generally in contact with the lateral hypodermis and the pseudocoelom (Wormatlas). C_elegans_phenotype_ontology long excretory canals WBPhenotype:0000440 excretory canals long The structure made by the processes of the excretory canal cell is increased in size compared to control. In C. elegans this is an H-shaped structure which extends almost the full length of the body on both sides of the animal, generally in contact with the lateral hypodermis and the pseudocoelom (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Tails change shape and undergo retraction thereby forming a 'peloderan' or 'rounded' adult tail. C_elegans_phenotype_ontology WBPhenotype:0000441 tail rounded Tails change shape and undergo retraction thereby forming a 'peloderan' or 'rounded' adult tail. WB:WBPerson2021 WB:WBPerson557 The developmental progression of a larva over time, from its formation to its mature structure is delayed compared to control. The larva is the early, immature form of an animal between hatching and adulthood. C_elegans_phenotype_ontology WBPhenotype:0000442 larval development retarded The developmental progression of a larva over time, from its formation to its mature structure is delayed compared to control. The larva is the early, immature form of an animal between hatching and adulthood. WB:WBPerson2021 WB:WBPerson557 Any variation in the appearance of the elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) compared to control. spicule morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000443 spicule morphology variant Any variation in the appearance of the elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) compared to control. WB:WBPerson2021 WB:WBPerson557 The length of the adult male tail, including the lateral fan and rays, is extended compared to control. C_elegans_phenotype_ontology WBPhenotype:0000444 bursa elongated The length of the adult male tail, including the lateral fan and rays, is extended compared to control. WB:WBPerson2021 WB:WBPerson557 Males generate yolk, the nutrient protein, normally produced and secreted by hermaphrodite or female intestinal cells. C_elegans_phenotype_ontology vitellogenin synthesis in males WBPhenotype:0000445 yolk synthesis in males Males generate yolk, the nutrient protein, normally produced and secreted by hermaphrodite or female intestinal cells. WB:WBPerson2021 WB:WBPerson557 Animals execute extra larval molts compared to control. C_elegans_phenotype_ontology WBPhenotype:0000446 supernumerary molt Animals execute extra larval molts compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of an animal over time from the end of larval stage to a mature adult compared to control animals. adult development abnormal C_elegans_phenotype_ontology WBPhenotype:0000447 adult development variant Variations in the progression of an animal over time from the end of larval stage to a mature adult compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time in adults compared to control animals (Wormatlas). adult cuticle development abnormal C_elegans_phenotype_ontology WBPhenotype:0000448 adult cuticle development variant Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time in adults compared to control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 A duplication of the developmental program that forms the adult-type rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells. C_elegans_phenotype_ontology WBPhenotype:0000449 second adult cuticle A duplication of the developmental program that forms the adult-type rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells. WB:WBPaper00001439 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000450 obsolete swollen male tail true Any irregular swelling in discrete regions of the head. C_elegans_phenotype_ontology WBPhenotype:0000451 head protrusion Any irregular swelling in discrete regions of the head. WB:WBPerson2021 WB:WBPerson557 Any irregular swelling in discrete regions of the tail, usually caused by a local defect in the normal smooth tapering of the hypodermis and/or cuticle (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000452 tail protrusions Any irregular swelling in discrete regions of the tail, usually caused by a local defect in the normal smooth tapering of the hypodermis and/or cuticle (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any irregular swelling in discrete regions of the body region between the head and the tail. C_elegans_phenotype_ontology WBPhenotype:0000453 body protrusions Any irregular swelling in discrete regions of the body region between the head and the tail. WB:WBPerson2021 WB:WBPerson557 The anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring)of the body appears distorted, usually due to uncharacteristic winding. C_elegans_phenotype_ontology WBPhenotype:0000454 head twisted The anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring)of the body appears distorted, usually due to uncharacteristic winding. WB:WBPerson2021 WB:WBPerson557 Animals exhibit abrupt transitions while traveling from one location to another. C_elegans_phenotype_ontology WBPhenotype:0000455 jerky movement Animals exhibit abrupt transitions while traveling from one location to another. WB:WBPerson2021 WB:WBPerson557 Variations in characteristic response with respect to perception or transmission of a touch stimulus compared to responses in control animals. C_elegans_phenotype_ontology touch insensitive WBPhenotype:0000456 touch resistant Variations in characteristic response with respect to perception or transmission of a touch stimulus compared to responses in control animals. WB:WBPerson557 Animals show enhanced suceptibility to deprivation of nourishment, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000457 organism starvation hypersensitive Animals show enhanced suceptibility to deprivation of nourishment, compared to control. WB:WBPerson2021 Animals show enhanced tolerance to deprivation of nourishment, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000458 starvation resistant Animals show enhanced tolerance to deprivation of nourishment, compared to control. WB:WBPerson2021 Animals exhibit variations in their response to any chemical substance that is used for killing pests, compared to that observed in control animals. pesticide response abnormal C_elegans_phenotype_ontology WBPhenotype:0000459 pesticide response variant Animals exhibit variations in their response to any chemical substance that is used for killing pests, compared to that observed in control animals. WB:WBPerson557 Animals exhibit variations in their response to paraquat compared to that observed in control animals. paraquat response abnormal C_elegans_phenotype_ontology methyl viologen response abnormal WBPhenotype:0000460 paraquat response variant Animals exhibit variations in their response to paraquat compared to that observed in control animals. WB:WBPerson557 Animals fail to respond to the concentration of paraquat that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000461 paraquat resistant Animals fail to respond to the concentration of paraquat that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals respond to paraquat at a lower concentration or a shorter exposure compared to control animals. reactive oxygen species hypersensitive C_elegans_phenotype_ontology WBPhenotype:0000462 paraquat hypersensitive Animals respond to paraquat at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 reactive oxygen species hypersensitive WB:WBPaper00031296 Animals exhibit variations in processes that are responsible for chemical changes compared to control animals. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. metabolic pathway abnormal C_elegans_phenotype_ontology WBPhenotype:0000463 metabolic pathway variant Animals exhibit variations in processes that are responsible for chemical changes compared to control animals. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. GO:0008152 WB:WBPerson712 Animals exhibit variations in their response to oxygen compared to that observed in control animals. oxygen response abnormal C_elegans_phenotype_ontology WBPhenotype:0000464 oxygen response variant Animals exhibit variations in their response to oxygen compared to that observed in control animals. WB:WBPerson557 Animals fail to respond to the high concentrations of oxygen that elicit a response in control animals. C_elegans_phenotype_ontology WBPhenotype:0000465 high oxygen resistant Animals fail to respond to the high concentrations of oxygen that elicit a response in control animals. WB:WBPerson2021 Animals respond to hyperoxic (high oxygen tension) conditions after a shorter exposure time compared to control. C_elegans_phenotype_ontology WBPhenotype:0000466 high oxygen hypersensitive Animals respond to hyperoxic (high oxygen tension) conditions after a shorter exposure time compared to control. GO:0055093 WB:WBPerson2021 Animals exhibit an increase in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000467 age associated fluorescence increased Animals exhibit an increase in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control. WB:WBPaper00033040 WB:WBPerson2021 Animals exhibit a decrease in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000468 age associated fluorescence reduced Animals exhibit a decrease in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control. WB:WBPerson2021 The daughters of the Q neuroblasts exhibit variation in their characteristic movements compared to control animals. Q neuroblast lineage migration abnormal C_elegans_phenotype_ontology WBPhenotype:0000469 Q neuroblast lineage migration variant The daughters of the Q neuroblasts exhibit variation in their characteristic movements compared to control animals. WB:WBPaper00001954 WB:WBPaper00031356 WB:WBPerson712 Any variation in the normal anterior movement of the HSN motor neurons from their birthplace in the tail to positions near the middle of the embryo compared to control animals. HSN migration abnormal C_elegans_phenotype_ontology WBPhenotype:0000470 HSN migration variant Any variation in the normal anterior movement of the HSN motor neurons from their birthplace in the tail to positions near the middle of the embryo compared to control animals. WB:WBPaper00001836 WB:WBPerson2021 Any variation in the normal posterior movement of the ALM mechanosensory neurons from their birthplace (anterior to the V1 hypodermal cell) to positions in between the V2 and V3 cells in the embryo compared to control animals. ALM migration abnormal C_elegans_phenotype_ontology WBPhenotype:0000471 ALM migration variant Any variation in the normal posterior movement of the ALM mechanosensory neurons from their birthplace (anterior to the V1 hypodermal cell) to positions in between the V2 and V3 cells in the embryo compared to control animals. WB:WBPaper00001304 WB:WBPaper00003058 WB:WBPerson2021 Animals lack the early blast cells that give rise to the gut tissue (Wormatlas). gutless C_elegans_phenotype_ontology WBPhenotype:0000472 endoderm absent Animals lack the early blast cells that give rise to the gut tissue (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals become increasingly sluggish/immobilized as they age. C_elegans_phenotype_ontology WBPhenotype:0000473 progressive paralysis Animals become increasingly sluggish/immobilized as they age. WB:WBPaper00001709 Any variation in the connection of the cell(s) whose principal function is to provide contractile forces with its neighboring cells or tissues compared to control. Mua muscle attachment abnormal C_elegans_phenotype_ontology WBPhenotype:0000474 muscle attachment variant Any variation in the connection of the cell(s) whose principal function is to provide contractile forces with its neighboring cells or tissues compared to control. WB:WBPerson2021 WB:WBPerson557 Animals fail to establish or maintain the connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues. C_elegans_phenotype_ontology WBPhenotype:0000475 muscle detached Animals fail to establish or maintain the connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues. WB:WBPerson2021 WB:WBPerson557 The connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues diminishes over time. C_elegans_phenotype_ontology WBPhenotype:0000476 progressive muscle detachment The connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues diminishes over time. WB:WBPerson2021 WB:WBPerson557 Any variation in the change in direction of a wave of light after passage through the nucleolus compared to control. The nucleolus is a small dense body in the nucleus. nucleolus refraction abnormal C_elegans_phenotype_ontology WBPhenotype:0000477 nucleolus refraction variant Any variation in the change in direction of a wave of light after passage through the nucleolus compared to control. The nucleolus is a small dense body in the nucleus. WB:WBPerson2021 WB:WBPerson557 Variations in the ability of an animal to remain within a defined temperature. In C. elegans, animals tend to track and stay within a temperature that is most closely related to their cultivation temperature. isothermal tracking behavior abnormal C_elegans_phenotype_ontology thermotaxis abnormal WBPhenotype:0000478 isothermal tracking behavior variant Variations in the ability of an animal to remain within a defined temperature. In C. elegans, animals tend to track and stay within a temperature that is most closely related to their cultivation temperature. WB:WBPaper00002214 Eggs show deficiencies in chroma resulting in increased translucency. C_elegans_phenotype_ontology WBPhenotype:0000479 egg pale Eggs show deficiencies in chroma resulting in increased translucency. WB:WBPerson2021 WB:WBPerson557 Failure to execute the characteristic response to pyrazine as defined by control animals. In C. elegans pyrazine is typically an attractant. C_elegans_phenotype_ontology WBPhenotype:0000480 pyrazine chemotaxis defective Failure to execute the characteristic response to pyrazine as defined by control animals. In C. elegans pyrazine is typically an attractant. WB:WBPaper00001786 Any variation in the directed movement of an animal in response to chemical repellants as defined by control animals. negative chemotaxis abnormal C_elegans_phenotype_ontology chemical avoidance abnormal chemoaversion abnormal WBPhenotype:0000481 negative chemotaxis variant Any variation in the directed movement of an animal in response to chemical repellants as defined by control animals. GO:0050919 WB:cab Failure to execute the characteristic response to garlic as defined by control animals. In C. elegans, garlic is typically a repellent. C_elegans_phenotype_ontology WBPhenotype:0000482 garlic chemotaxis defective Failure to execute the characteristic response to garlic as defined by control animals. In C. elegans, garlic is typically a repellent. WB:WBPaper00001374 Animals lack the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes. In C. elegans these contents typically include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000483 no gut granules Animals lack the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes. In C. elegans these contents typically include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The organism's size during the embryonic developmental stage is decreased compared to that observed in control. C_elegans_phenotype_ontology WBPhenotype:0000484 embryo small The organism's size during the embryonic developmental stage is decreased compared to that observed in control. WB:WBPerson2021 WB:WBPerson557 The survival of animals in the alternative larval stage which they enter when placed under conditions of environmental stress is reduced. C_elegans_phenotype_ontology reduced dauer survival WBPhenotype:0000485 dauer death increased The survival of animals in the alternative larval stage which they enter when placed under conditions of environmental stress is reduced. WB:WBPerson2021 WB:WBPerson557 Animals respond to colchicine at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000486 colchicine hypersensitive Animals respond to colchicine at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of colchicine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000487 colchicine resistant Animals fail to respond to the concentration of colchicine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals respond to chloroquine at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000488 chloroquine hypersensitive Animals respond to chloroquine at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of chloroquine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000489 chloroquine resistant Animals fail to respond to the concentration of chloroquine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 The components of the feeding organ fail to be arranged in the same manner as control animals. C_elegans_phenotype_ontology WBPhenotype:0000490 pharynx disorganized The components of the feeding organ fail to be arranged in the same manner as control animals. WB:WBPerson2021 WB:WBPerson557 Any observed morphological defects of the isthmus. isthmus morphology abnormal C_elegans_phenotype_ontology isthmus malformed WBPhenotype:0000491 isthmus morphology defective Any observed morphological defects of the isthmus. WB:WBPerson2021 Any variation in the form, structure or composition of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb compared to control (Wormatlas). corpus morphology abnormal C_elegans_phenotype_ontology corpus malformed WBPhenotype:0000492 corpus morphology defective Any variation in the form, structure or composition of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb compared to control (Wormatlas). WB:WBPerson2021 Any variation in the form, structure or composition of the first pharyngeal bulb compared to control. metacorpus morphology abnormal C_elegans_phenotype_ontology metacarpas malformed WBPhenotype:0000493 metacorpus morphology defective Any variation in the form, structure or composition of the first pharyngeal bulb compared to control. WB:WBPerson2021 Cessation of development that normally occurs in C. elegans 460-520 min after the first cleavage at 20C, the stage between the 1.5-fold and 3-fold embryo. C_elegans_phenotype_ontology WBPhenotype:0000494 two fold arrest Cessation of development that normally occurs in C. elegans 460-520 min after the first cleavage at 20C, the stage between the 1.5-fold and 3-fold embryo. WB:WBPerson101 Animals have finger-like sensory sensilla (rays) that are present in places they are normally not found, when compared to the location in control animals. C_elegans_phenotype_ontology WBPhenotype:0000495 ray ectopic Animals have finger-like sensory sensilla (rays) that are present in places they are normally not found, when compared to the location in control animals. WB:WBPerson2021 WB:WBPerson557 Males lack the specialized sensory papillae that lie along the posterior half of the body. C_elegans_phenotype_ontology WBPhenotype:0000496 male postdeirid sensilla absent Males lack the specialized sensory papillae that lie along the posterior half of the body. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in their response to gamma ray radiation compared to that observed in control animals. organism gamma ray response abnormal C_elegans_phenotype_ontology WBPhenotype:0000497 organism gamma ray response variant Animals exhibit variations in their response to gamma ray radiation compared to that observed in control animals. WB:WBPerson557 Animals exhibit variations in their response to methyl methanesulfonate compared to that observed in control animals. methyl methanesulfonate response abnormal C_elegans_phenotype_ontology MMS response abnormal WBPhenotype:0000498 methyl methanesulfonate response variant Animals exhibit variations in their response to methyl methanesulfonate compared to that observed in control animals. WB:WBPerson557 Animals exhibit variations in their response to ethyl methanesulfonate (EMS) compared to that observed in control animals. ethyl methanesulfonate response abnormal C_elegans_phenotype_ontology EMS response abnormal WBPhenotype:0000499 ethyl methanesulfonate response variant Animals exhibit variations in their response to ethyl methanesulfonate (EMS) compared to that observed in control animals. WB:WBPerson557 Animals respond to an acetylcholinesterase inhibitor at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000500 acetylcholinesterase inhibitor hypersensitive Animals respond to an acetylcholinesterase inhibitor at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern in the left-handed direction. In liquid media, wave propogation is helical rather than planar. C_elegans_phenotype_ontology Rol WBPhenotype:0000501 left handed roller The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern in the left-handed direction. In liquid media, wave propogation is helical rather than planar. WB:WBPerson2021 WB:WBPerson557 The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern in the right-handed direction. In liquid media, wave propogation is helical rather than planar. Rol C_elegans_phenotype_ontology WBPhenotype:0000502 right handed roller The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern in the right-handed direction. In liquid media, wave propogation is helical rather than planar. WB:WBPerson2021 WB:WBPerson557 Any variation in the multiple rounds of DNA replication that take place without chromosome condensation, segregation or cytokinesis compared to control. In C. elegans this process is normally seen in intestinal nuclei during each larval lethargus which results in adult intestinal nuclei with 32 copies (32C) of each chromosome(Wormatlas). endoreduplication abnormal C_elegans_phenotype_ontology WBPhenotype:0000503 endoreduplication variant Any variation in the multiple rounds of DNA replication that take place without chromosome condensation, segregation or cytokinesis compared to control. In C. elegans this process is normally seen in intestinal nuclei during each larval lethargus which results in adult intestinal nuclei with 32 copies (32C) of each chromosome(Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei, compared to control. nuclear division abnormal C_elegans_phenotype_ontology karyokinesis abnormal WBPhenotype:0000504 Possible XP. nuclear division variant Any variation in the process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei, compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the structure or organization of any of the finger-like sensory sensilla that project from the tail and embed in the male fan compared to control animals. In C. elegans, nine bilateral rays project from the tail in a radial pattern with a smooth and slightly tapered appearance. Although one neuronal member of each ray sensillum is exposed to the outside, male rays rarely take up dye. Ram male ray morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000505 male ray morphology variant Animals exhibit variations in the structure or organization of any of the finger-like sensory sensilla that project from the tail and embed in the male fan compared to control animals. In C. elegans, nine bilateral rays project from the tail in a radial pattern with a smooth and slightly tapered appearance. Although one neuronal member of each ray sensillum is exposed to the outside, male rays rarely take up dye. WB:WBPaper00000932 WB:WBPaper00001328 WB:WBPaper00002149 WB:WBPaper00029016 WB:WBPerson712 The adult male tail, including the lateral fan and rays, appears bloated or distended. swollen male tail C_elegans_phenotype_ontology WBPhenotype:0000506 bursa swollen The adult male tail, including the lateral fan and rays, appears bloated or distended. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the amount of acetylcholine compared to control animals at a defined stage. Acetylcholine is the acetic acid ester of the organic base choline. acetylcholine levels abnormal C_elegans_phenotype_ontology WBPhenotype:0000507 acetylcholine levels variant Animals exhibit variations in the amount of acetylcholine compared to control animals at a defined stage. Acetylcholine is the acetic acid ester of the organic base choline. WB:WBPerson2021 WB:WBPerson557 Animals exhibit a decrease in the regulated breakdown of mRNA transcripts in which an amino-acid codon has changed to a premature stop codon and the 3 prime end is not protected by a poly(A) tail. C_elegans_phenotype_ontology WBPhenotype:0000508 nonsense mRNA accumulation Animals exhibit a decrease in the regulated breakdown of mRNA transcripts in which an amino-acid codon has changed to a premature stop codon and the 3 prime end is not protected by a poly(A) tail. GO:0070478 WB:WBPerson2021 WB:WBPerson557 Variation in the morphological appearance or composition of the pseudopod, a cellular projection that facilitates motility of the spermatozoa. sperm pseudopod abnormal C_elegans_phenotype_ontology WBPhenotype:0000509 sperm pseudopod variant Variation in the morphological appearance or composition of the pseudopod, a cellular projection that facilitates motility of the spermatozoa. WB:WBPaper00001075 WB:WBPerson2021 The characteristic Christmas-tree shaped invagination formed by the terminal vulval cells at the mid-late L4 stage is altered. WBPhenotype:0000287 vulval invagination L4 abnormal vulval invagination abnormal C_elegans_phenotype_ontology vulval invagination L4 variant WBPhenotype:0000510 vulval invagination variant L4 The characteristic Christmas-tree shaped invagination formed by the terminal vulval cells at the mid-late L4 stage is altered. WB:WBPaper00001738 WB:WBPerson2021 Variations in the directed movement of the nucleus to a specific location within a cell compared to control. nuclear positioning abnormal C_elegans_phenotype_ontology nuclear migration variant WBPhenotype:0000511 Possible XP. nuclear positioning variant Variations in the directed movement of the nucleus to a specific location within a cell compared to control. GO:0007097 WB:WBPerson2021 WB:WBPerson557 Variations in spacing or location were observed between adjacent ventral cord nuclei or between ventral cord nuclei and another nucleus used as a reference point. In C. elegans, these nuclei are distributed equally and predictably, such that they can be unambiguously distinguished by their position. VNC nuclear positioning abnormal C_elegans_phenotype_ontology VNC nuclear migration variant WBPhenotype:0000512 VNC nuclear positioning variant Variations in spacing or location were observed between adjacent ventral cord nuclei or between ventral cord nuclei and another nucleus used as a reference point. In C. elegans, these nuclei are distributed equally and predictably, such that they can be unambiguously distinguished by their position. WB:WBPaper00031891 WB:WBPerson712 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000513 obsolete touch response abnormal true When prodded on the head, worm contracts and then relaxes along its entire body without moving backwards, compared to a control worm which contracts its anterior end and backs away in response to prodding. Rbr rubberband C_elegans_phenotype_ontology WBPhenotype:0000514 rubber band When prodded on the head, worm contracts and then relaxes along its entire body without moving backwards, compared to a control worm which contracts its anterior end and backs away in response to prodding. WB:WBPaper00006135 WB:WBPerson2021 Variations in any process whose specific outcome is the development and/or maintenance of the ventral nerve cord. ventral nerve cord development abnormal C_elegans_phenotype_ontology WBPhenotype:0000515 ventral nerve cord development variant Variations in any process whose specific outcome is the development and/or maintenance of the ventral nerve cord. WB:WBPerson557 The longitudinal nerve cord of the midbody region, connecting the nerve ring and tail ganglia, is not arranged in the same manner as control animals. C_elegans_phenotype_ontology WBPhenotype:0000516 ventral cord disorganized The longitudinal nerve cord of the midbody region, connecting the nerve ring and tail ganglia, is not arranged in the same manner as control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the specific actions or reactions in response to external or internal stimuli compared to that observed in control animals. behavior abnormal behavior variant C_elegans_phenotype_ontology WBPhenotype:0000517 behavior phenotype Variations in the specific actions or reactions in response to external or internal stimuli compared to that observed in control animals. GO:0007610 WB:WBPerson557 Variations in the progression of an integrated living unit (a cell, tissue, organ or organism) over time from an initial condition to a later condition compared to control animals. development abnormal development variant C_elegans_phenotype_ontology WBPhenotype:0000518 development phenotype Variations in the progression of an integrated living unit (a cell, tissue, organ or organism) over time from an initial condition to a later condition compared to control animals. GO:0032502 WB:WBPerson2021 Animals exhibit variations in any physical or chemical process required for the cell, tissue, organ system or organism to carry out its normal functions and activities or be able to perceive and respond to stimuli compared to control animals. physiology abnormal physiology variant C_elegans_phenotype_ontology WBPhenotype:0000519 physiology phenotype Animals exhibit variations in any physical or chemical process required for the cell, tissue, organ system or organism to carry out its normal functions and activities or be able to perceive and respond to stimuli compared to control animals. WB:WBPerson712 Animals exhibit variations in the form, structure or composition of any of its parts compared to control animals. morphology abnormal morphology variant C_elegans_phenotype_ontology WBPhenotype:0000520 morphology phenotype Animals exhibit variations in the form, structure or composition of any of its parts compared to control animals. WB:WBPerson712 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency. pigmentation abnormal pigmentation variant C_elegans_phenotype_ontology WBPhenotype:0000521 pigmentation phenotype Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency. WB:WBPerson2021 WB:WBPerson557 WB:WBPerson712 Variations in the specific actions or reactions of a certain defined body area of an animal in response to external or internal stimuli compared to that observed in control animals. organism region behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000522 organism region behavior variant Variations in the specific actions or reactions of a certain defined body area of an animal in response to external or internal stimuli compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in their response to a specific chemical compared to that observed in control animals. chemical response abnormal C_elegans_phenotype_ontology WBPhenotype:0000523 chemical response variant Animals exhibit variations in their response to a specific chemical compared to that observed in control animals. WB:WBPerson557 Animals exhibit variations in their response to bleach compared to that observed in control animals. bleach response abnormal C_elegans_phenotype_ontology WBPhenotype:0000524 bleach response variant Animals exhibit variations in their response to bleach compared to that observed in control animals. WB:WBPerson557 Variations in the specific actions or reactions of an organism in response to external or internal stimuli compared to that observed in control organisms. organism behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000525 organism behavior variant Variations in the specific actions or reactions of an organism in response to external or internal stimuli compared to that observed in control organisms. GO:0007610 WB:WBPerson557 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a cell. cell pigmentation abnormal cell pigmentation variant C_elegans_phenotype_ontology WBPhenotype:0000526 cell pigmentation phenotype Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a cell. WB:WBPerson557 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the organism. organism pigmentation abnormal organism pigmentation variant C_elegans_phenotype_ontology Abnormal Coloration WBPhenotype:0000527 organism pigmentation phenotype Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the organism. WB:WBPerson557 Variations in the progression of the overall structure or appearance of a discrete region of an animal's anatomy over time from an initial condition to a later condition compared to control animals. body region development abnormal C_elegans_phenotype_ontology WBPhenotype:0000528 body region development variant Variations in the progression of the overall structure or appearance of a discrete region of an animal's anatomy over time from an initial condition to a later condition compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of a cell from when it is first formed to when it becomes a mature structure when compared to control animals. cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000529 cell development variant Any variation in the progression of a cell from when it is first formed to when it becomes a mature structure when compared to control animals. GO:0048468 WB:cab Any variation in the progression of an organismal system from its formation to the mature structure when compared to control animals. organ system development abnormal C_elegans_phenotype_ontology WBPhenotype:0000530 organ system development variant Any variation in the progression of an organismal system from its formation to the mature structure when compared to control animals. GO:0048731 WB:cab Any variation in the progression of a worm at any time from its fertilization to adulthood compared to control. organism development abnormal C_elegans_phenotype_ontology WBPhenotype:0000531 organism development variant Any variation in the progression of a worm at any time from its fertilization to adulthood compared to control. WB:cab Animals exhibit variations in the form, structure or composition of a discrete region of their anatomy compared to control animals. body region morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000532 body region morphology variant Animals exhibit variations in the form, structure or composition of a discrete region of their anatomy compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the form or composition of the basic structural and functional unit of all organisms compared to control. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000533 cell morphology variant Any variation in the form or composition of the basic structural and functional unit of all organisms compared to control. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. GO:0005623 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that comprise a specific organ system. organ system morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000534 organ system morphology variant Animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that comprise a specific organ system. WB:WBPerson557 Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals. Bmd organism morphology abnormal C_elegans_phenotype_ontology body morphology defects WBPhenotype:0000535 organism morphology variant Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals. WB:WBPaper00004402 WB:WBPaper00004403 WB:WBPaper00004651 WB:WBPaper00005654 WB:WBPaper00006395 WB:cab Animals exhibit variations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for the cell to carry out its normal functions or be able to perceive and respond to stimuli, compared to control animals. cell physiology abnormal cell physiology variant C_elegans_phenotype_ontology WBPhenotype:0000536 cell physiology phenotype Animals exhibit variations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for the cell to carry out its normal functions or be able to perceive and respond to stimuli, compared to control animals. GO:0009987 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000537 obsolete synaptic input abnormal true OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000538 obsolete synaptic output abnormal true Variations in the progression of the anatomical structures that consist of processes of ventral cord motor neurons that send commissures to the dorsal side, as well as processes of certain head and tail neurons, over time from initial formation to mature structure compared to control (Wormatlas). dorsal nerve cord development abnormal C_elegans_phenotype_ontology WBPhenotype:0000539 dorsal nerve cord development variant Variations in the progression of the anatomical structures that consist of processes of ventral cord motor neurons that send commissures to the dorsal side, as well as processes of certain head and tail neurons, over time from initial formation to mature structure compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the progression of the process extension from the muscle belly by which the muscle cells reach to the nerve cords to obtain innervation over time from initial formation to mature structure compared to control (Wormatlas). muscle arm development abnormal C_elegans_phenotype_ontology muscle arm extension variant WBPhenotype:0000540 muscle arm development variant Variations in the progression of the process extension from the muscle belly by which the muscle cells reach to the nerve cords to obtain innervation over time from initial formation to mature structure compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 WB:WBPerson712 Axon tracts fail to complete the connection between nerve cords. In C. elegans, these tracts grow circumferentially around the animal, completing the connection between the ventral and dorsal nerve cords. C_elegans_phenotype_ontology WBPhenotype:0000541 cord commissures fail to reach target Axon tracts fail to complete the connection between nerve cords. In C. elegans, these tracts grow circumferentially around the animal, completing the connection between the ventral and dorsal nerve cords. WB:WBPaper00001499 WB:WBPaper00028984 WB:WBPerson712 Animals exhibit an increased girth compared to a control animal of the same developmental stage. C_elegans_phenotype_ontology increased girth thick WBPhenotype:0000542 fat Animals exhibit an increased girth compared to a control animal of the same developmental stage. WB:WBPerson2021 WB:WBPerson557 Forward movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control. Animal moves forward with uncharacteristic loss of smooth sinusoidal motion or body posture (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000543 forward kinker Forward movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control. Animal moves forward with uncharacteristic loss of smooth sinusoidal motion or body posture (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Backward movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control. Animal moves backward with uncharacteristic loss of smooth sinusoidal motion or body posture (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000544 backward kinker Backward movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control. Animal moves backward with uncharacteristic loss of smooth sinusoidal motion or body posture (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Eggs are retained in the uterus at a later stage when compared with control animals. Ret C_elegans_phenotype_ontology late eggs laid WBPhenotype:0000545 egg retention Eggs are retained in the uterus at a later stage when compared with control animals. WB:cab Eggs are laid at an earlier stage of development when compared with control animals. C_elegans_phenotype_ontology WBPhenotype:0000546 early eggs laid Eggs are laid at an earlier stage of development when compared with control animals. WB:cab Animals exhibit morphological characteristics that are the outcome of nutrient deprivation. In C. elegans, starved worms have fewer refractile granules in intestinal cells, making them appear pale. Strongly starved mutants are small and thin, and tend to retain fewer eggs than control animals. C_elegans_phenotype_ontology Eat WBPhenotype:0000547 starved Animals exhibit morphological characteristics that are the outcome of nutrient deprivation. In C. elegans, starved worms have fewer refractile granules in intestinal cells, making them appear pale. Strongly starved mutants are small and thin, and tend to retain fewer eggs than control animals. WB:WBPaper00001709 WB:WBPerson2021 Progressive degeneration of muscle. C_elegans_phenotype_ontology WBPhenotype:0000548 muscle dystrophy Progressive degeneration of muscle. WB:cab Progressive degeneration of the head muscle. C_elegans_phenotype_ontology WBPhenotype:0000549 head muscle dystrophy Progressive degeneration of the head muscle. WB:cab Progressive degeneration of muscle along the body wall. C_elegans_phenotype_ontology body wall muscle dystrophy WBPhenotype:0000550 body muscle dystrophy Progressive degeneration of muscle along the body wall. WB:cab Animals exhibit variations in the rate of sharp head to tail turns compared to control animals. omega turns abnormal C_elegans_phenotype_ontology WBPhenotype:0000551 omega turns variant Animals exhibit variations in the rate of sharp head to tail turns compared to control animals. WB:WBPaper00000075 WB:WBPaper00006375 WB:WBPerson712 Animals exhibit variations in the amount of GABA compared to control animals at a defined stage. GABA levels abnormal C_elegans_phenotype_ontology WBPhenotype:0000552 GABA levels variant Animals exhibit variations in the amount of GABA compared to control animals at a defined stage. WB:WBPerson2021 WB:WBPerson557 Animals exhibit a weak and abnormal birefringency pattern in muscle fibers when examined using polarized optics. WBPhenotype:0000714 Dim disorganized muscle C_elegans_phenotype_ontology muscle birefringence abnormal WBPhenotype:0000553 Disorganized muscle fibers display a weak and abnormal birefringency pattern when examined using polarized optics. muscle birefringence variant Animals exhibit a weak and abnormal birefringency pattern in muscle fibers when examined using polarized optics. WB:WBPerson557 Any variation in the ability to adjust to a decline in ambient solute concentrations, thereby causing the body to swell and explode. C_elegans_phenotype_ontology WBPhenotype:0000554 hypoosmotic shock hypersensitive Any variation in the ability to adjust to a decline in ambient solute concentrations, thereby causing the body to swell and explode. WB:WBPaper00000484 WB:WBPerson2021 Animals show variations in their decreased responsiveness after prolonged or repeated exposure to a drug compared to that in control. drug adaptation abnormal C_elegans_phenotype_ontology WBPhenotype:0000555 drug adaptation variant Animals show variations in their decreased responsiveness after prolonged or repeated exposure to a drug compared to that in control. WB:WBPerson2021 WB:WBPerson557 Animals show variations in their decreased responsiveness after prolonged or repeated exposure to dopamine compared to that in control. dopamine adaptation abnormal C_elegans_phenotype_ontology WBPhenotype:0000556 dopamine adaptation variant Animals show variations in their decreased responsiveness after prolonged or repeated exposure to dopamine compared to that in control. WB:WBPerson2021 WB:WBPerson557 Animals do not exhibit decreased responsiveness after prolonged or repeated exposure to dopamine. C_elegans_phenotype_ontology WBPhenotype:0000557 dopamine adaptation defective Animals do not exhibit decreased responsiveness after prolonged or repeated exposure to dopamine. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in their response to specific calcium channel modulators compared to that observed in control animals. calcium channel modulator response abnormal C_elegans_phenotype_ontology WBPhenotype:0000558 calcium channel modulator response variant Animals exhibit variations in their response to specific calcium channel modulators compared to that observed in control animals. WB:WBPerson557 Animals respond to a calcium channel modulator at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000559 calcium channel modulator hypersensitive Animals respond to a calcium channel modulator at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of calcium channel modulators that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000560 calcium channel modulator resistant Animals fail to respond to the concentration of calcium channel modulators that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 The heads of animals fail to respond to the concentration of levamisole that elicits a response in control animals. In C. elegans, heads contract at >10uM for intact animals and >1uM for cut animals. C_elegans_phenotype_ontology head tetramisole resistant WBPhenotype:0000561 head levamisole resistant The heads of animals fail to respond to the concentration of levamisole that elicits a response in control animals. In C. elegans, heads contract at >10uM for intact animals and >1uM for cut animals. WB:WBPaper00000484 The bodies of animals fail to respond to the concentration of levamisole that elicits a response in control animals. C_elegans_phenotype_ontology body tetramisole resistant WBPhenotype:0000562 body levamisole resistant The bodies of animals fail to respond to the concentration of levamisole that elicits a response in control animals. WB:WBPaper00000484 The whole body undergoes longitudinal shortening in response to head touch or tail touch (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000563 shrinker The whole body undergoes longitudinal shortening in response to head touch or tail touch (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Muscle contractions that make up the defecation motor program are repeated before the onset of the next cycle unlike in control animals. C_elegans_phenotype_ontology WBPhenotype:0000564 echo defecation cycle Muscle contractions that make up the defecation motor program are repeated before the onset of the next cycle unlike in control animals. WB:WBPaper00002305 WB:WBPaper00003765 WB:WBPerson712 The body of an animal assumes a coil-like shape when it attempts to move. C_elegans_phenotype_ontology curler WBPhenotype:0000565 coiler The body of an animal assumes a coil-like shape when it attempts to move. WB:WBPerson363 A coiling body that bends ventrally. C_elegans_phenotype_ontology ventral curler WBPhenotype:0000566 ventral coiler A coiling body that bends ventrally. WB:WBPerson363 A coiling body that bends dorsally. C_elegans_phenotype_ontology dorsal curler WBPhenotype:0000567 dorsal coiler A coiling body that bends dorsally. WB:WBperson363 Animals display variations in the structure or organization of the components of the axon, compared to that observed in control animals. axon ultrastructure abnormal C_elegans_phenotype_ontology WBPhenotype:0000568 axon ultrastructure variant Animals display variations in the structure or organization of the components of the axon, compared to that observed in control animals. WB:WBPaper00001499 WB:WBPerson712 Animals display markedly swollen areas along their axons, which are larger than synaptic varicosities in control animals. C_elegans_phenotype_ontology WBPhenotype:0000569 axon varicosities Animals display markedly swollen areas along their axons, which are larger than synaptic varicosities in control animals. WB:WBPaper00001499 WB:WBPaper00024595 WB:WBPerson712 Axons of animals contain flattened membrane-bound compartments. In C. elegans, these cisternae-like structures are typically absent. C_elegans_phenotype_ontology WBPhenotype:0000570 axon cisternae Axons of animals contain flattened membrane-bound compartments. In C. elegans, these cisternae-like structures are typically absent. WB:WBPaper00001499 WB:WBPaper00024595 WB:WBPerson712 Axons of animals exhibit variations in the gross structure or organization of its spherical, membrane-bound, fluid-filled organelles, compared to that observed in control animals. abnormal axon vesicle C_elegans_phenotype_ontology WBPhenotype:0000571 axon vesicle variant Axons of animals exhibit variations in the gross structure or organization of its spherical, membrane-bound, fluid-filled organelles, compared to that observed in control animals. WB:WBPaper00001499 WB:WBPerson712 Any variation in the processes that govern the extension of neuronal projections. neuronal outgrowth abnormal C_elegans_phenotype_ontology WBPhenotype:0000572 neuronal outgrowth variant Any variation in the processes that govern the extension of neuronal projections. WB:WBPerson2021 OBSOLETE. neuronal branching abnormal C_elegans_phenotype_ontology WBPhenotype:0000573 obsolete neuronal branching variant true OBSOLETE. WB:WBPerson557 The structure made by the processes of the excretory canal cell is reduced in size compared to control. In C. elegans this is an H-shaped structure which extends almost the full length of the body on both sides of the animal, generally in contact with the lateral hypodermis and the pseudocoelom (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000574 excretory canal short The structure made by the processes of the excretory canal cell is reduced in size compared to control. In C. elegans this is an H-shaped structure which extends almost the full length of the body on both sides of the animal, generally in contact with the lateral hypodermis and the pseudocoelom (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in a physical or chemical process required for organs or tissues to carry out their normal functions or for their ability to perceive and respond to stimuli compared to control. organ system physiology abnormal organ system physiology variant C_elegans_phenotype_ontology WBPhenotype:0000575 organ system physiology phenotype Animals exhibit variations in a physical or chemical process required for organs or tissues to carry out their normal functions or for their ability to perceive and respond to stimuli compared to control. GO:0003008 Animals exhibit variations in any physical or chemical process required for the organism to carry out its normal function or be able to perceive and respond to stimuli. organism physiology abnormal organism physiology variant C_elegans_phenotype_ontology WBPhenotype:0000576 organism physiology phenotype Animals exhibit variations in any physical or chemical process required for the organism to carry out its normal function or be able to perceive and respond to stimuli. WB:WBPerson712 Variations in the chemical reactions and pathways involved in the maintenance of a steady-state at the level of the organism compared to control. organism homeostasis metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000577 organism homeostasis metabolism variant Variations in the chemical reactions and pathways involved in the maintenance of a steady-state at the level of the organism compared to control. GO:0048871 WB:WBPerson2021 WB:WBPerson557 Variations in the progression of a discrete axis of an animal's anatomy over time, compared to control animals. body axis development abnormal C_elegans_phenotype_ontology WBPhenotype:0000578 body axis development variant Variations in the progression of a discrete axis of an animal's anatomy over time, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of the overall structure or appearance of any anterior/posterior section of an animal's anatomy over time from an initial condition to a later condition compared to control animals. organism segment development abnormal C_elegans_phenotype_ontology WBPhenotype:0000579 organism segment development variant Variations in the progression of the overall structure or appearance of any anterior/posterior section of an animal's anatomy over time from an initial condition to a later condition compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the specific actions or reactions of a certain body region of an animal in response to external or internal stimuli compared to that observed in control animals. organism segment behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000580 organism segment behavior variant Variations in the specific actions or reactions of a certain body region of an animal in response to external or internal stimuli compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of a discrete axis (dorsal/ventral/anterior/posterior/transverse) of their anatomy, compared to control animals. body axis morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000581 body axis morphology variant Animals exhibit variations in the form, structure or composition of a discrete axis (dorsal/ventral/anterior/posterior/transverse) of their anatomy, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of any anterior/posterior section of their anatomy compared to control animals. organism segment morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000582 organism segment morphology variant Animals exhibit variations in the form, structure or composition of any anterior/posterior section of their anatomy compared to control animals. WB:WBPerson2021 WB:WBPerson557 Worms are shorter and stouter than control animals at the same developmental stage. Dpy C_elegans_phenotype_ontology WBPhenotype:0000583 dumpy Worms are shorter and stouter than control animals at the same developmental stage. WB:WBPaper00004402 WB:WBPaper00004403 WB:WBPaper00004651 WB:WBPaper00005654 WB:WBPaper00006395 WB:WBPaper00024497 WB:cab WB:cgc31 Any variation in the process of communication across a synapse between a neuron and a target cell (neuron, muscle, or secretory cell) compared to control animals. WBPhenotype:0000537 WBPhenotype:0000538 synaptic input variant synaptic output variant synaptic input abnormal synaptic output abnormal synaptic transmission abnormal C_elegans_phenotype_ontology WBPhenotype:0000584 synaptic transmission variant Any variation in the process of communication across a synapse between a neuron and a target cell (neuron, muscle, or secretory cell) compared to control animals. GO:0007268 WB:cab Variations in the chemical reactions and pathways involved in the maintenance of a steady-state at the level of the cell compared to control. cell homeostasis metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000585 cell homeostasis metabolism variant Variations in the chemical reactions and pathways involved in the maintenance of a steady-state at the level of the cell compared to control. GO:0019725 WB:WBPerson2021 Animals respond to bleach at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000586 bleach hypersensitive Animals respond to bleach at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 OBSOLETE. lectin staining abnormal C_elegans_phenotype_ontology WBPhenotype:0000587 obsolete lectin staining variant true OBSOLETE. WB:WBPerson557 OBSOLETE. no male abnormal C_elegans_phenotype_ontology WBPhenotype:0000588 This phenotype was intended to reflect a lack of any phenotypic abnormality in the individuals in question. The C. elegans phenotype ontology no longer has terms specifically used to assert negation of a phenotype. obsolete no male variantity scored true OBSOLETE. WB:WBPerson557 OBSOLETE. no hermaphrodite abnormal C_elegans_phenotype_ontology WBPhenotype:0000589 This phenotype was intended to reflect a lack of any phenotypic abnormality in the individuals in question. The C. elegans phenotype ontology no longer has terms specifically used to assert negation of a phenotype. obsolete no hermaphrodite variantity scored true OBSOLETE. WB:WBPerson557 Animals exhibit differences in the number of cell corpses compared to controls at the same developmental life stage. cell corpse number abnormal C_elegans_phenotype_ontology WBPhenotype:0000590 cell corpse number variant Animals exhibit differences in the number of cell corpses compared to controls at the same developmental life stage. WB:WBPerson712 Animals exhibit variations in their response to a specific metal compared to that observed in control animals. metal response abnormal C_elegans_phenotype_ontology WBPhenotype:0000591 metal response variant Animals exhibit variations in their response to a specific metal compared to that observed in control animals. WB:WBPerson557 Animals exhibit variations in their response to copper compared to that observed in control animals. copper response abnormal C_elegans_phenotype_ontology WBPhenotype:0000592 copper response variant Animals exhibit variations in their response to copper compared to that observed in control animals. WB:WBPerson557 Animals respond to copper at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000593 copper hypersensitive Animals respond to copper at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Any variation in the orderly movement of a cell from one site to another. Mig cell migration abnormal C_elegans_phenotype_ontology migration of cells abnormal WBPhenotype:0000594 cell migration variant Any variation in the orderly movement of a cell from one site to another. GO:0016477 WB:cab Variations in the specific actions or reactions of the head in response to external or internal stimuli compared to that observed in control animals. head behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000595 head behavior variant Variations in the specific actions or reactions of the head in response to external or internal stimuli compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 WB:cab Activity characteristic of the body is altered compared to control. body behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000596 body behavior variant Activity characteristic of the body is altered compared to control. WB:cab Variations in the specific actions or reactions of the tail in response to external or internal stimuli compared to that observed in control animals. tail behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000597 tail behavior variant Variations in the specific actions or reactions of the tail in response to external or internal stimuli compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the form, structure or composition of the series of related tissues lying within the body cavity and devoted to feeding and digestion compared to control (Wormatlas). alimentary system morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000598 alimentary system morphology variant Variations in the form, structure or composition of the series of related tissues lying within the body cavity and devoted to feeding and digestion compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the coelomic system, compared to control. The coelom is the fluid compartment that is in contact with internal organ. coelomic system morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000599 coelomic system morphology variant Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the coelomic system, compared to control. The coelom is the fluid compartment that is in contact with internal organ. WB:WBPerson2021 WB:WBPerson557 Variations in the form, composition or structure of the epithelial system that serves to protect the organism from the external environment compared to control. epithelial system morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000600 epithelial system morphology variant Variations in the form, composition or structure of the epithelial system that serves to protect the organism from the external environment compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the form, structure or composition of related tissues that allow the animal to secrete saline fluid and maintain a proper salt balance compared to control. In C. elegans, four cell types (1 pore cell, 1 duct cell, 1 canal cell and a fused pair of gland cells) make up the excretory system (Wormatlas). WBPhenotype:0000602 excretory system morphology variant excretory secretory system morphology abnormal excretory system morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000601 excretory secretory system morphology variant Variations in the form, structure or composition of related tissues that allow the animal to secrete saline fluid and maintain a proper salt balance compared to control. In C. elegans, four cell types (1 pore cell, 1 duct cell, 1 canal cell and a fused pair of gland cells) make up the excretory system (Wormatlas). WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000602 obsolete excretory system morphology abnormal true Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the muscle system, compared to control. The muscle system consists of tissues made up of various elongated cells that are specialized to contract and produce movement and mechanical work. muscle system morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000603 muscle system morphology variant Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the muscle system, compared to control. The muscle system consists of tissues made up of various elongated cells that are specialized to contract and produce movement and mechanical work. GO:0007517 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in control animals. nervous system morphology abnormal C_elegans_phenotype_ontology neuroanatomical defective WBPhenotype:0000604 WB:WBbt:0005735. nervous system morphology variant Animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in control animals. WB:WBPerson712 Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the reproductive system, compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents. reproductive system morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000605 reproductive system morphology variant Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the reproductive system, compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the alimentary system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. alimentary system physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000606 alimentary system physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the alimentary system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. GO:0003008 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the coelomic system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. coelomic system physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000607 coelomic system physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the coelomic system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. GO:0003008 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the epithelial system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. epithelial system physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000608 epithelial system physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the epithelial system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. GO:0003008 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the excretory/secretory system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. excretory secretory system physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000609 excretory secretory system physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the excretory/secretory system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. GO:0003008 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the secretory system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. excretory system physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000610 excretory system physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the secretory system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. GO:0003008 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. muscle system physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000611 muscle system physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. GO:0003008 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the nervous system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. nervous system physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000612 nervous system physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the nervous system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. GO:0003008 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the reproductive system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. reproductive system physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000613 reproductive system physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the reproductive system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. GO:0003008 WB:WBPerson557 WB:WBPerson712 Any variation in the progression of the GLR accessory cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. GLR development abnormal C_elegans_phenotype_ontology WBPhenotype:0000614 GLR development variant Any variation in the progression of the GLR accessory cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. WB:WBPerson2021 Animals exhibit variations in the structure or organization of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals. In C. elegans, cilia are classified as channel cilia or wing cilia depending on their placement within the sensillum. Channel cilia of control animals are cylindrical, extend into the sensillum pore and are exposed to the outside. Wing cilia of control animals vary in shape, are embedded in the sensillum sheath cell and are not typically refractory to dyes indicating exposure to the outside. cilia morphology abnormal C_elegans_phenotype_ontology defective dye filling of cilia WBPhenotype:0000615 cilia morphology variant Animals exhibit variations in the structure or organization of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals. In C. elegans, cilia are classified as channel cilia or wing cilia depending on their placement within the sensillum. Channel cilia of control animals are cylindrical, extend into the sensillum pore and are exposed to the outside. Wing cilia of control animals vary in shape, are embedded in the sensillum sheath cell and are not typically refractory to dyes indicating exposure to the outside. WB:WBPaper00000214 WB:WBPaper00000932 WB:WBPerson712 Animals display variations in the appearance of the subcellular junctional structure composed of a presynaptic terminal directly opposite the post-synaptic target and separated by a synaptic cleft. synapse morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000616 synapse morphology variant Animals display variations in the appearance of the subcellular junctional structure composed of a presynaptic terminal directly opposite the post-synaptic target and separated by a synaptic cleft. GO:0045202 WB:WBPaper00027305 WB:WBPerson712 Any variation in the progression of the alimentary system over time, from its formation to its mature state compared to control. The alimentary system includes all the body structures involved in preparing food for absorption into the body and excretion of waste products. alimentary system development abnormal C_elegans_phenotype_ontology WBPhenotype:0000617 alimentary system development variant Any variation in the progression of the alimentary system over time, from its formation to its mature state compared to control. The alimentary system includes all the body structures involved in preparing food for absorption into the body and excretion of waste products. WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the coelomic system over time, from its formation to its mature state compared to control. coelomic system development abnormal C_elegans_phenotype_ontology WBPhenotype:0000618 coelomic system development variant Any variation in the progression of the coelomic system over time, from its formation to its mature state compared to control. WB:WBPerson2021 Any variation in the progression of the epithelial system over time, from its formation to its mature state compared to control. epithelial system development abnormal C_elegans_phenotype_ontology WBPhenotype:0000619 epithelial system development variant Any variation in the progression of the epithelial system over time, from its formation to its mature state compared to control. WB:WBPerson2021 Any variation in the progression of the excretory secretory system over time, from its formation to its mature state compared to control. The excretory secretory system consists of the excretory system and its associated glands. excretory secretory system development abnormal C_elegans_phenotype_ontology WBPhenotype:0000620 excretory secretory system development variant Any variation in the progression of the excretory secretory system over time, from its formation to its mature state compared to control. The excretory secretory system consists of the excretory system and its associated glands. WB:WBPerson2021 Variations in the progression of the excretory system over time, from its formation to the mature structure. The excretory system is required for the elimination of metabolic waste. In C. elegans, the excretory system is comprised of the excretory cell, excretory duct cell and excretory socket cell. excretory system development abnormal C_elegans_phenotype_ontology WBPhenotype:0000621 excretory system development variant Variations in the progression of the excretory system over time, from its formation to the mature structure. The excretory system is required for the elimination of metabolic waste. In C. elegans, the excretory system is comprised of the excretory cell, excretory duct cell and excretory socket cell. WB:WBPerson2021 Any variation in the progression of the muscle system over time, from its formation to its mature state compared to control. muscle system development abnormal C_elegans_phenotype_ontology WBPhenotype:0000622 muscle system development variant Any variation in the progression of the muscle system over time, from its formation to its mature state compared to control. WB:WBPerson2021 Any variation in the progression of nervous tissue over time, from its formation to its mature state compared to control. nervous system development abnormal C_elegans_phenotype_ontology WBPhenotype:0000623 nervous system development variant Any variation in the progression of nervous tissue over time, from its formation to its mature state compared to control. GO:0007399 WB:cab Any variation in the progression of the reproductive system over time, from its formation to its mature state compared to control. reproductive system development abnormal C_elegans_phenotype_ontology reproductive defect WBPhenotype:0000624 reproductive system development variant Any variation in the progression of the reproductive system over time, from its formation to its mature state compared to control. WB:WBPerson2021 Any variation in the biosynthesis of a synapse compared to control. synapse development variant synaptogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0000625 synaptogenesis variant Any variation in the biosynthesis of a synapse compared to control. GO:0007416 WB:cab synapse development variant WB:WBPerson712 Any variation in the decrease in a behavioral response to a repeated stimulus compared to control. habituation abnormal C_elegans_phenotype_ontology non associative learning variant WBPhenotype:0000626 habituation variant Any variation in the decrease in a behavioral response to a repeated stimulus compared to control. GO:0046959 WB:cab Animals exhibit variations in their response to a specific anesthetic compared to that observed in control animals. anaesthetic response variant anesthetic response abnormal C_elegans_phenotype_ontology WBPhenotype:0000627 anesthetic response variant Animals exhibit variations in their response to a specific anesthetic compared to that observed in control animals. WB:WBPerson557 Early embryos exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. Emb C_elegans_phenotype_ontology WBPhenotype:0000628 Possible XP. spindle assembly defective early emb Early embryos exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. GO:0051225 WB:WBPerson2021 WB:cab WB:cgc7141 Any variation that causes an increase in the frequency of neurite (axon or dendrite) outgrowth. As a result, an excess number of neuronal projections are generated. C_elegans_phenotype_ontology WBPhenotype:0000629 excess neurite outgrowth Any variation that causes an increase in the frequency of neurite (axon or dendrite) outgrowth. As a result, an excess number of neuronal projections are generated. WB:WBPerson2021 Failure to execute the characteristic response to the bitter tastant quinine, as defined by control animals. In C. elegans, quinine is typically repellent. C_elegans_phenotype_ontology WBPhenotype:0000630 quinine chemotaxis defective Failure to execute the characteristic response to the bitter tastant quinine, as defined by control animals. In C. elegans, quinine is typically repellent. WB:WBPaper00006481 WB:WBPaper00035961 WB:WBPerson712 Any variation in the characteristic response(s) to drug(s) as defined by control animals. C_elegans_phenotype_ontology drug response abnormal WBPhenotype:0000631 drug response variant Any variation in the characteristic response(s) to drug(s) as defined by control animals. WB:cab The ability of axons to converge and form a bundle of nerve fibres (fascicle) is compromised. axon fasciculation abnormal C_elegans_phenotype_ontology WBPhenotype:0000632 axon fasciculation variant The ability of axons to converge and form a bundle of nerve fibres (fascicle) is compromised. GO:0007413 WB:WBPerson2021 WB:WBPerson557 Animals display variations in the number or pattern of axonal tracts stemming from the neuron cell body, compared to that observed in control animals. axon branching abnormal C_elegans_phenotype_ontology WBPhenotype:0000633 axon branching variant Animals display variations in the number or pattern of axonal tracts stemming from the neuron cell body, compared to that observed in control animals. GO:0048755 WB:WBPaper00027335 WB:WBPaper00027711 WB:WBPerson712 Any variation in the contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes compared to control. pharyngeal pumping abnormal C_elegans_phenotype_ontology WBPhenotype:0000634 pharyngeal pumping variant Any variation in the contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes compared to control. GO:0043050 WB:cab Any variation in the directed movement of an animal in response to chemical attractants as defined by control animals. positive chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0000635 positive chemotaxis variant Any variation in the directed movement of an animal in response to chemical attractants as defined by control animals. GO:0050918 WB:cab WB:cgc122 WB:cgc387 Any variation in the ability of neurons to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles under conditions that ellicit this response in control animals. neuron degeneration abnormal C_elegans_phenotype_ontology WBPhenotype:0000636 neuron degeneration variant Any variation in the ability of neurons to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles under conditions that ellicit this response in control animals. WB:WBPerson2021 WB:WBPerson557 Characteristic entry into the dauer stage is altered compared to control animals. Daf dauer formation abnormal C_elegans_phenotype_ontology WBPhenotype:0000637 dauer formation variant Characteristic entry into the dauer stage is altered compared to control animals. WB:cab Animals exhibit defects in the process of periodic shedding, of part or all of its cuticle, during cuticle replacement that punctuates each larval stage. Mlt Mult C_elegans_phenotype_ontology WBPhenotype:0000638 molt defect Animals exhibit defects in the process of periodic shedding, of part or all of its cuticle, during cuticle replacement that punctuates each larval stage. GO:0018996 WB:WBPerson712 Animals exhibit variations in the entry into the dauer stage when exposed to temperatures that induce dauer formation in control animals. In C. elegans, many Daf-c animals enter dauer at 25C, whereas Hid animals enter dauer at 27C. temperature induced dauer formation abnormal C_elegans_phenotype_ontology Hid WBPhenotype:0000639 temperature induced dauer formation variant Animals exhibit variations in the entry into the dauer stage when exposed to temperatures that induce dauer formation in control animals. In C. elegans, many Daf-c animals enter dauer at 25C, whereas Hid animals enter dauer at 27C. WB:WBPaper00006103 WB:WBPerson2021 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in the stage of eggs laid, egg laying cycle, number of eggs or egg laying in response to stimuli compared to control. Egl egg laying abnormal C_elegans_phenotype_ontology oviposition abnormal WBPhenotype:0000640 Visual inspection. egg laying variant Animals exhibit variations in the stage of eggs laid, egg laying cycle, number of eggs or egg laying in response to stimuli compared to control. WB:cab pmid:11813735 pmid:9697864 oviposition abnormal GO:0018991 Any variation in the degree of movement compared to control animals. activity level abnormal C_elegans_phenotype_ontology WBPhenotype:0000641 activity level variant Any variation in the degree of movement compared to control animals. WB:cab Worms move forward or backward with an increased rate of body bends per minute compared to control animals. Hya C_elegans_phenotype_ontology WBPhenotype:0000642 hyperactive Worms move forward or backward with an increased rate of body bends per minute compared to control animals. WB:WBPaper00004402 WB:WBPaper00006395 WB:cab Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals. Unc locomotion abnormal C_elegans_phenotype_ontology movement defect uncoordinated WBPhenotype:0000643 locomotion variant Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals. GO:0040011 WB:WBPaper00024949 WB:WBPerson712 WB:cab Animals do not move and are not responsive to external mechanical stimulation. Prl C_elegans_phenotype_ontology Prz WBPhenotype:0000644 paralyzed Animals do not move and are not responsive to external mechanical stimulation. WB:cab The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern. In liquid media, wave propogation is helical rather than planar. Rol C_elegans_phenotype_ontology WBPhenotype:0000645 roller The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern. In liquid media, wave propogation is helical rather than planar. WB:cab WB:cgc31 Animals move more slowly compared with control animals. Slu C_elegans_phenotype_ontology lethargic slow WBPhenotype:0000646 sluggish Animals move more slowly compared with control animals. WB:cab Animals exhibit variations in any processes that lead to the successful transfer of sperm from one organism to another. copulation abnormal C_elegans_phenotype_ontology WBPhenotype:0000647 copulation variant Animals exhibit variations in any processes that lead to the successful transfer of sperm from one organism to another. GO:0007620 WB:cab Any variation in the specific actions or reactions of the male that are associated with reproduction compared to control. Cod male mating abnormal C_elegans_phenotype_ontology WBPhenotype:0000648 male mating variant Any variation in the specific actions or reactions of the male that are associated with reproduction compared to control. GO:0060179 WB:cab Any variation in the male's ability to locate his partner's vulva when backing along the ventral side of the partner during mating compared to control. In C. elegans the male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate. vulva location abnormal C_elegans_phenotype_ontology Lov WBPhenotype:0000649 vulva location variant Any variation in the male's ability to locate his partner's vulva when backing along the ventral side of the partner during mating compared to control. In C. elegans the male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate. GO:0034608 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the processes involved in eliminating gut contents compared to control animals. In C. elegans the sequence of events during defecation includes posterior body contraction (pBoc), relaxation, anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp), and intercycle period (Wormatlas). defecation abnormal C_elegans_phenotype_ontology WBPhenotype:0000650 defecation variant Animals exhibit variations in the processes involved in eliminating gut contents compared to control animals. In C. elegans the sequence of events during defecation includes posterior body contraction (pBoc), relaxation, anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp), and intercycle period (Wormatlas). GO:0030421 WB:WBPerson2021 WB:WBPerson557 WB:cab Animals exhibit delayed or infrequent passage and/or expulsion of fecal matter. Con C_elegans_phenotype_ontology WBPhenotype:0000651 constipated Animals exhibit delayed or infrequent passage and/or expulsion of fecal matter. WB:WBPerson2021 Variations in the progression of a set of interacting or interdependent entities forming the sensory system over time from an initial condition to a later condition compared to control animals. The sensory system is involved in the perception of a stimuli, its conversion into a signal and the recognition and characterization of the resulting signal. WBPhenotype:0000248 sensory system abnormal C_elegans_phenotype_ontology WBPhenotype:0000652 sensory system variant Variations in the progression of a set of interacting or interdependent entities forming the sensory system over time from an initial condition to a later condition compared to control animals. The sensory system is involved in the perception of a stimuli, its conversion into a signal and the recognition and characterization of the resulting signal. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of a set of interacting or interdependent entities forming the mechanosensory system over time from an initial condition to a later condition compared to control animals. The mechanosensory system is involved in the perception of a mechanical stimuli, its conversion into a signal and the recognition and characterization of the resulting signal. mechanosensory system abnormal C_elegans_phenotype_ontology WBPhenotype:0000653 mechanosensory system variant Variations in the progression of a set of interacting or interdependent entities forming the mechanosensory system over time from an initial condition to a later condition compared to control animals. The mechanosensory system is involved in the perception of a mechanical stimuli, its conversion into a signal and the recognition and characterization of the resulting signal. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the fusion of intracellular neurotransmitter-filled membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell compared to control. synaptic vesicle exocytosis abnormal C_elegans_phenotype_ontology WBPhenotype:0000654 synaptic vesicle exocytosis variant Animals exhibit variations in the fusion of intracellular neurotransmitter-filled membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell compared to control. GO:0016079 WB:WBPerson712 Animals exhibit variations in the process of GABA neurotransmitter-based communication from a neuron to a target cell across a synapse compared to control. GABA synaptic transmission abnormal C_elegans_phenotype_ontology WBPhenotype:0000655 GABA synaptic transmission variant Animals exhibit variations in the process of GABA neurotransmitter-based communication from a neuron to a target cell across a synapse compared to control. GO:0007268 WB:WBPerson712 Animals exhibit variations in the process of acetylcholine neurotransmitter-based communication from a neuron to a target cell across a synapse compared to control. acetylcholine synaptic transmission abnormal C_elegans_phenotype_ontology WBPhenotype:0000656 acetylcholine synaptic transmission variant Animals exhibit variations in the process of acetylcholine neurotransmitter-based communication from a neuron to a target cell across a synapse compared to control. GO:0007268 WB:WBPerson712 Any variation in the process of information transfer between two neurons; usually in reference to chemical synapses, but can also be used to refer to electrical synapses compared to control (Wormatlas). neuronal synaptic transmission abnormal C_elegans_phenotype_ontology WBPhenotype:0000657 neuronal synaptic transmission variant Any variation in the process of information transfer between two neurons; usually in reference to chemical synapses, but can also be used to refer to electrical synapses compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the process of communication across a synapse between a neuron and a target muscle cell compared to control animals. neuromuscular synaptic transmission abnormal C_elegans_phenotype_ontology WBPhenotype:0000658 neuromuscular synaptic transmission variant Any variation in the process of communication across a synapse between a neuron and a target muscle cell compared to control animals. WB:WBPerson2021 WB:WBPerson557 Behavior associated with the intake of food is altered compared to control. feeding behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000659 feeding behavior variant Behavior associated with the intake of food is altered compared to control. GO:0007631 WB:WBPerson557 Worms are found in clumps and/or crowded at the border of the bacterial lawn more frequently than control animals. This behavior is not due to mobility defects. C_elegans_phenotype_ontology bordering increased social behavior enhanced WBPhenotype:0000660 social feeding increased Worms are found in clumps and/or crowded at the border of the bacterial lawn more frequently than control animals. This behavior is not due to mobility defects. WB:WBPerson712 Animals disperse across a bacterial lawn and feed alone. When food is limiting, they can aggregate into swarms or clumps, but disperse once again when food is absent. C_elegans_phenotype_ontology solitary behavior enhanced solitary forager on food WBPhenotype:0000661 solitary feeding increased Animals disperse across a bacterial lawn and feed alone. When food is limiting, they can aggregate into swarms or clumps, but disperse once again when food is absent. WB:WBPaper00003187 WB:WBPaper00032342 WB:WBPerson712 Variations in the behavior by which an organism locates food compared to control animals. In C. elegans roaming or dwelling activity on food are two examples of parameters used to assess this behavior. Roaming is defined as moving in a high-speed forward direction with brief backward movement, often traversing wide regions. Dwelling is defined as low-speed/high turning movement restricted to a confined region. Fab foraging behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000662 foraging behavior variant Variations in the behavior by which an organism locates food compared to control animals. In C. elegans roaming or dwelling activity on food are two examples of parameters used to assess this behavior. Roaming is defined as moving in a high-speed forward direction with brief backward movement, often traversing wide regions. Dwelling is defined as low-speed/high turning movement restricted to a confined region. GO:0060756 WB:WBPaper00005621 WB:WBPaper00031455 WB:WBPerson712 Animals exhibit variations in the avoidance response to solutions of a particular osmotic strength compared to control. In C. elegans, animals typically avoid solutions of high osmotic strength. osmotic avoidance abnormal C_elegans_phenotype_ontology Osm WBPhenotype:0000663 osmotic avoidance variant Animals exhibit variations in the avoidance response to solutions of a particular osmotic strength compared to control. In C. elegans, animals typically avoid solutions of high osmotic strength. WB:WBPerson2021 The maximum ventral and dorsal flex of the animal is greater than that observed for control animals. WBPhenotype:0004021 C_elegans_phenotype_ontology loopy WBPhenotype:0000664 exaggerated body bends The maximum ventral and dorsal flex of the animal is greater than that observed for control animals. WB:WBPerson712 Any variation that disrupts the connectivity between the somatic gonad and the adjoining tissues compared to control. In C. elegans this connnection is between the somatic gonad and the vulva in hermaphrodites and between the somatic gonad and proctodeum in males. connection of gonad abnormal C_elegans_phenotype_ontology Cog WBPhenotype:0000665 connection of gonad variant Any variation that disrupts the connectivity between the somatic gonad and the adjoining tissues compared to control. In C. elegans this connnection is between the somatic gonad and the vulva in hermaphrodites and between the somatic gonad and proctodeum in males. WB:WBPerson2021 WB:WBPerson557 Any variation that disrupts the release of a mature oocyte into the spermatheca (for subsequent fertilization), compared to control. ovulation abnormal C_elegans_phenotype_ontology WBPhenotype:0000666 ovulation variant Any variation that disrupts the release of a mature oocyte into the spermatheca (for subsequent fertilization), compared to control. GO:0030728 WB:WBPaper00003017 WB:WBPerson2021 The specialized tissue of the reproductive tract that produces gamete is shifted from its customary place as defined by control. C_elegans_phenotype_ontology ectopic gonad WBPhenotype:0000667 gonad displaced The specialized tissue of the reproductive tract that produces gamete is shifted from its customary place as defined by control. WB:WBPerson2021 WB:WBPerson557 Any variation that results in the presence of mature oocytes with distended polyploid nuclei. In C. elegans, such oocytes mature and exit diakinesis, but are often not properly ovulated or fertilized. Emo C_elegans_phenotype_ontology arrest in meiosis I WBPhenotype:0000668 endomitotic oocytes Any variation that results in the presence of mature oocytes with distended polyploid nuclei. In C. elegans, such oocytes mature and exit diakinesis, but are often not properly ovulated or fertilized. WB:kmva Variations in the progression of the muscles of the adult reproductive system over time form their initial formation to their mature structure compared to control. sex muscle development abnormal C_elegans_phenotype_ontology WBPhenotype:0000669 sex muscle development variant Variations in the progression of the muscles of the adult reproductive system over time form their initial formation to their mature structure compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the processes that influence the generation and maturation of spermatozoa (motile sperm) compared to control. Spe spermatocyte germ cell differentiation abnormal spermatogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0000670 spermatogenesis variant Any variation in the processes that influence the generation and maturation of spermatozoa (motile sperm) compared to control. GO:0007283 WB:WBPaper00027300 WB:WBPerson2021 Animals fail to respond to the concentration of copper that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to copper to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000671 resistant to copper Animals fail to respond to the concentration of copper that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to copper to elicit the response compared to control animals. WB:WBPerson557 Animals display variations in the distribution of transmitter-filled vesicles in relation to the electron-dense membrane specialization of the neuron,compared to that observed in control animals. presynaptic vesicle cluster localization abnormal C_elegans_phenotype_ontology synaptic vesicle cluster localization abnormal WBPhenotype:0000672 presynaptic vesicle cluster localization variant Animals display variations in the distribution of transmitter-filled vesicles in relation to the electron-dense membrane specialization of the neuron,compared to that observed in control animals. WB:WBPaper00027305 WB:WBPaper00027711 WB:WBPerson712 The number of offspring produced is altered compared to that of control animals. brood size abnormal C_elegans_phenotype_ontology WBPhenotype:0000673 brood size variant The number of offspring produced is altered compared to that of control animals. WB:WBPerson557 The developmental progression of an animal, from its formation to its mature structure occurs over a longer time period compared to control. C_elegans_phenotype_ontology retarded development WBPhenotype:0000674 slow development The developmental progression of an animal, from its formation to its mature structure occurs over a longer time period compared to control. WB:WBPerson2021 WB:WBPerson557 Animals die after fusion of gametes without dividing. C_elegans_phenotype_ontology Emb WBPhenotype:0000675 zygotic lethal Animals die after fusion of gametes without dividing. WB:WBPerson2021 WB:WBPerson557 The increase in size or mass of an organism over time during the lifespan of the organism or over any developmental stage(s) is not similar to that observed for control animals. growth rate abnormal C_elegans_phenotype_ontology WBPhenotype:0000676 growth rate variant The increase in size or mass of an organism over time during the lifespan of the organism or over any developmental stage(s) is not similar to that observed for control animals. GO:0040007 WB:WBPerson712 Animals fail to receive, process or recognize a sensory chemical stimulus in the same manner as control animals. C_elegans_phenotype_ontology WBPhenotype:0000677 chemosensation defective Animals fail to receive, process or recognize a sensory chemical stimulus in the same manner as control animals. WB:WBPerson2021 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000678 This phenotype was intended to reflect a lack of any phenotypic abnormality in the individuals in question. The C. elegans phenotype ontology no longer has terms specifically used to assert negation of a phenotype. obsolete no copper sensitivity true OBSOLETE. WB:WBPerson557 Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals. transgene subcellular localization abnormal C_elegans_phenotype_ontology WBPhenotype:0000679 transgene subcellular localization variant Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals. WB:WBPerson557 Animals exhibit variations in their response to aldicarb compared to that observed in control animals. aldicarb response abnormal C_elegans_phenotype_ontology WBPhenotype:0000680 aldicarb response variant Animals exhibit variations in their response to aldicarb compared to that observed in control animals. WB:WBPerson557 Animals exhibit variations in their response to DMPP compared to that observed in control animals. DMPP response abnormal C_elegans_phenotype_ontology WBPhenotype:0000681 DMPP response variant Animals exhibit variations in their response to DMPP compared to that observed in control animals. WB:WBPerson557 Hermaphrodites are transformed into fertile females; In C. elegans, XO fog animals are somatically male but produce oocytes instead of, or in addition to, sperm. Fog feminization of germ line C_elegans_phenotype_ontology WBPhenotype:0000682 feminization of germline Hermaphrodites are transformed into fertile females; In C. elegans, XO fog animals are somatically male but produce oocytes instead of, or in addition to, sperm. WB:cab pmid:3396865 The germ line is sexually transformed from hermaphrodite to male. In C. elegans, XX mog animals are somatically hermaphrodite, but germ cells that normally would become oocytes are transformed into sperm. Mog masculinization of germ line C_elegans_phenotype_ontology WBPhenotype:0000683 masculinization of germline The germ line is sexually transformed from hermaphrodite to male. In C. elegans, XX mog animals are somatically hermaphrodite, but germ cells that normally would become oocytes are transformed into sperm. WB:WBPaper00001710 WB:WBPerson2021 Germ cell populations are reduced compared to control animals. Fgc C_elegans_phenotype_ontology germline underproliferation WBPhenotype:0000684 fewer germ cells Germ cell populations are reduced compared to control animals. WB:WBPerson2021 WB:cab Any variation that causes a reduction in growth rate during larval stages compared to control. C_elegans_phenotype_ontology WBPhenotype:0000685 larval growth slow Any variation that causes a reduction in growth rate during larval stages compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in their response ionizing radiation compared to that observed in control animals. organism ionizing radiation response abnormal C_elegans_phenotype_ontology WBPhenotype:0000686 organism ionizing radiation response variant Animals exhibit variations in their response ionizing radiation compared to that observed in control animals. WB:WBPerson557 Both hermaphrodites and males develop into fertile females. Fem C_elegans_phenotype_ontology WBPhenotype:0000687 feminization of XX and XO animals Both hermaphrodites and males develop into fertile females. WB:cab Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce. Ste semi sterile C_elegans_phenotype_ontology WBPhenotype:0000688 sterile Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce. GO:0000003 WB:WBPerson712 Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility). Ste Reduced fecundity of injected worm C_elegans_phenotype_ontology sterile F0 fertility problems WBPhenotype:0000689 maternal sterile Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility). WB:WBPerson557 WB:cab WB:cgc5599 WB:cgc7141 Reduced fecundity of injected worm WB:cgc5599 Variations in the gross movement of the whole structure of the gonad along the body wall, behind the gonadal leader cell and away from the developing vulva compared to control (Wormatlas). Gom gonad migration abnormal C_elegans_phenotype_ontology WBPhenotype:0000690 gonad migration variant Variations in the gross movement of the whole structure of the gonad along the body wall, behind the gonadal leader cell and away from the developing vulva compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the progression of the organ that produces gametes over time, from its formation to the mature structure compared to control. gonad development abnormal C_elegans_phenotype_ontology Gon gonadogenesis abnormal WBPhenotype:0000691 gonad development variant Variations in the progression of the organ that produces gametes over time, from its formation to the mature structure compared to control. GO:0008406 WB:WBPerson2021 X0 animals fail to generate viable cross-progeny. C_elegans_phenotype_ontology WBPhenotype:0000692 male sterile X0 animals fail to generate viable cross-progeny. WB:WBPerson2021 Any perturbation that renders male derived sperm ineffective at fertilizing an oocyte. Fer C_elegans_phenotype_ontology WBPhenotype:0000693 male sperm fertilization defect Any perturbation that renders male derived sperm ineffective at fertilizing an oocyte. WB:WBPaper00001075 WB:WBPerson2021 Hermaphrodites fail to generate viable self-progeny and/or cross-progeny. C_elegans_phenotype_ontology WBPhenotype:0000694 hermaphrodite sterile Hermaphrodites fail to generate viable self-progeny and/or cross-progeny. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the gross structure or organization of the reproductive organ required for depositing eggs and for influencing male mating behavior compared to control. vulva morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000695 vulva morphology variant Animals exhibit variations in the gross structure or organization of the reproductive organ required for depositing eggs and for influencing male mating behavior compared to control. WB:WBPerson712 The eversion process, in which the vulval invagination is turned inside out during the final molt, is disrupted. In C.elegans, such variations in vulval eversion are primarily due to developmental defects in the somatic gonad (and sometimes vulva). Evl C_elegans_phenotype_ontology WBPhenotype:0000696 everted vulva The eversion process, in which the vulval invagination is turned inside out during the final molt, is disrupted. In C.elegans, such variations in vulval eversion are primarily due to developmental defects in the somatic gonad (and sometimes vulva). WB:WBPaper00001738 WB:WBPerson2021 WB:WBPerson261 WB:cab Animals undergo incomplete vulval morphogenesis, resulting in the formation of a single protrusion at the site of the vulva. Pvl Pvu C_elegans_phenotype_ontology WBPhenotype:0000697 protruding vulva Animals undergo incomplete vulval morphogenesis, resulting in the formation of a single protrusion at the site of the vulva. WB:WBPaper00004408 WB:WBPerson2021 No vulval tissue is produced. In C. elegans, this is usually a result of all six vulval precursor cells adopting a tertiary fate. Vul underinduced C_elegans_phenotype_ontology WBPhenotype:0000698 vulvaless No vulval tissue is produced. In C. elegans, this is usually a result of all six vulval precursor cells adopting a tertiary fate. WB:WBPaper00001182 WB:WBPerson2021 Variations in the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure compared to control. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. vulva development abnormal C_elegans_phenotype_ontology WBPhenotype:0000699 vulva development variant Variations in the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure compared to control. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. GO:0040025 WB:IA WB:WBPerson2021 Multiple vulva-like protrusions are present along the ventral side of the animal. In C. elegans, this is usually a result of all six vulval precursor cells adopting primary or secondary vulval fates. Muv overinduced C_elegans_phenotype_ontology WBPhenotype:0000700 multivulva Multiple vulva-like protrusions are present along the ventral side of the animal. In C. elegans, this is usually a result of all six vulval precursor cells adopting primary or secondary vulval fates. WB:WBPaper00001182 WB:WBPerson2021 Any variation in the progression of the epithelia over time, from its formation to its mature state compared to control. This process involves autonomously generated changes in epidermal cell shape and position, and interactions with internal tissues, including the developing nervous system and body wall muscles to affect epidermal enclosure, cell intercalation, and epidermal elongation. epithelial development abnormal C_elegans_phenotype_ontology epidermal morphogenesis variant WBPhenotype:0000701 epithelial development variant Any variation in the progression of the epithelia over time, from its formation to its mature state compared to control. This process involves autonomously generated changes in epidermal cell shape and position, and interactions with internal tissues, including the developing nervous system and body wall muscles to affect epidermal enclosure, cell intercalation, and epidermal elongation. WB:WBPerson2021 WB:WBPerson557 Any perturbation that renders epithelial cells incompetent at undergoing membrane fusion during development. PMID:15341747 C_elegans_phenotype_ontology WBPhenotype:0000702 epithelial cell fusion failure Any perturbation that renders epithelial cells incompetent at undergoing membrane fusion during development. WB:WBPaper00005122 WB:WBPerson2021 Variations in the form, composition or structure of the layer of cells that cover the external surface of an organism and form the inner lining between the tissues and organs of that organism and the external environment compared to control. In C. elegans epithelial cells include epithelium of the alimentary tract, intestinal cells, hypodermis, interfacial cells and somatic gonad cells (Wormatlas). epithelial morphology abnormal C_elegans_phenotype_ontology hypodermal morphology abnormal WBPhenotype:0000703 epithelial morphology variant Variations in the form, composition or structure of the layer of cells that cover the external surface of an organism and form the inner lining between the tissues and organs of that organism and the external environment compared to control. In C. elegans epithelial cells include epithelium of the alimentary tract, intestinal cells, hypodermis, interfacial cells and somatic gonad cells (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the form or composition of structures made by the processes of the excretory canal cell compared to control (Wormatlas). excretory canal morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000704 excretory canal morphology variant Variations in the form or composition of structures made by the processes of the excretory canal cell compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of an intestinal cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. intestinal cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000705 intestinal cell development variant Any variation in the progression of an intestinal cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. WB:WBPerson2021 Animals lack birefringent containing compartments in embryonic intestinal cells; however, these compartments appear in adult stages. Glo PMID:15843430 C_elegans_phenotype_ontology gut granule loss WBPhenotype:0000706 gut granule biogenesis reduced Animals lack birefringent containing compartments in embryonic intestinal cells; however, these compartments appear in adult stages. WB:WBPaper00032168 WB:WBPerson712 Variations in the progression of the pharynx (feeding organ) over time, from its formation to the mature structure compared to control. In C. elegans the pharynx is divided into the anterior and posterior regions. The anterior region includes the corpus (procorpus and metacorpus - first bulb) and the posterior region includes the isthmus and terminal bulb (second bulb). pharyngeal development abnormal C_elegans_phenotype_ontology WBPhenotype:0000707 pharyngeal development variant Variations in the progression of the pharynx (feeding organ) over time, from its formation to the mature structure compared to control. In C. elegans the pharynx is divided into the anterior and posterior regions. The anterior region includes the corpus (procorpus and metacorpus - first bulb) and the posterior region includes the isthmus and terminal bulb (second bulb). GO:0043282 WB:WBPerson2021 Variations in the progression of the intestine over time from its initial formation to its mature structure compared to control. intestinal development abnormal C_elegans_phenotype_ontology endoderm development abnormal gut development abnormal WBPhenotype:0000708 intestinal development variant Variations in the progression of the intestine over time from its initial formation to its mature structure compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the form or composition of the mouthparts at the anterior end of the digestive tract which contain a series of radial muscles, related neurons and epithelial cells, and several gland cells which may aid in digestion compared to control (Wormatlas). pharyngeal morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000709 pharyngeal morphology variant Variations in the form or composition of the mouthparts at the anterior end of the digestive tract which contain a series of radial muscles, related neurons and epithelial cells, and several gland cells which may aid in digestion compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion (Wormatlas). intestinal morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000710 intestinal morphology variant Animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit increased sensitivity to the effects of ion producing radiation compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000711 organism hypersensitive ionizing radiation Animals exhibit increased sensitivity to the effects of ion producing radiation compared to control animals. WB:WBPaper00000565 WB:WBPerson712 Germ cells exhibit variations in their response to ionizing radiation compared to that observed in control animals. germ cell ionizing radiation response abnormal C_elegans_phenotype_ontology WBPhenotype:0000712 germ cell ionizing radiation response variant Germ cells exhibit variations in their response to ionizing radiation compared to that observed in control animals. WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000713 obsolete spermatocyte division abnormal true OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000714 obsolete disorganized muscle true Animals exhibit a greater number of embryonic muscle cells compared to control. Mex C_elegans_phenotype_ontology WBPhenotype:0000715 muscle excess Animals exhibit a greater number of embryonic muscle cells compared to control. WB:WBPaper00001584 WB:kmva Mex WB:WBPaper00001584 Any variation in the connection of a cell whose principal function is to provide contractile forces with its neighboring cells or tissues compared to control. muscle cell attachment abnormal C_elegans_phenotype_ontology WBPhenotype:0000716 muscle cell attachment variant Any variation in the connection of a cell whose principal function is to provide contractile forces with its neighboring cells or tissues compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the processes that convert a gene's sequence into a mature gene product or products (proteins or RNA), compared to control. gene expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000717 gene expression variant Variations in the processes that convert a gene's sequence into a mature gene product or products (proteins or RNA), compared to control. GO:0010467 WB:WBPerson2021 Variations in the process of normalizing the expression level of X-linked genes between XX and XO animals compared to control. dosage compensation abnormal C_elegans_phenotype_ontology WBPhenotype:0000718 Possible XP GO:0007549. dosage compensation variant Variations in the process of normalizing the expression level of X-linked genes between XX and XO animals compared to control. GO:0007549 WB:WBPerson363 OBSOLETE. reporter gene expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000719 obsolete reporter gene expression variant true OBSOLETE. WB:WBPerson557 OBSOLETE. pattern of reporter gene expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000720 obsolete pattern of reporter gene expression variant true OBSOLETE. WB:WBPerson557 OBSOLETE. level of reporter gene expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000721 obsolete level of reporter gene expression variant true OBSOLETE. WB:WBPerson557 Animals exhibit variations in the appearance of nucleoli compared to control animals. nucleolus abnormal C_elegans_phenotype_ontology WBPhenotype:0000722 nucleolus variant Animals exhibit variations in the appearance of nucleoli compared to control animals. WB:cab OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000723 obsolete cellular secretion abnormal true Variations in the regulated release of proteins from a cell or group of cells compared to control. protein secretion abnormal C_elegans_phenotype_ontology WBPhenotype:0000724 protein secretion variant Variations in the regulated release of proteins from a cell or group of cells compared to control. GO:0009306 WB:WBPerson2021 Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of lipid within the organism or cell compared to control. lipid metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000725 lipid metabolism variant Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of lipid within the organism or cell compared to control. GO:0055088 WB:WBPaper00032000 WB:WBPaper00032082 WB:WBPerson712 Any variation of the specific binding of a molecule to its partner, which typically results in a change in cell activity, compared to control. ligand binding abnormal C_elegans_phenotype_ontology WBPhenotype:0000726 ligand binding variant Any variation of the specific binding of a molecule to its partner, which typically results in a change in cell activity, compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the function of naturally occurring macromolecular substances known as enzymes compared to control. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). enzyme activity abnormal C_elegans_phenotype_ontology WBPhenotype:0000727 enzyme activity variant Any variation in the function of naturally occurring macromolecular substances known as enzymes compared to control. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). GO:0003824 WB:WBPerson2021 WB:WBPerson557 Variations in the process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, compared to control. exocytosis abnormal C_elegans_phenotype_ontology WBPhenotype:0000728 exocytosis variant Variations in the process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, compared to control. GO:0006887 WB:WBPerson2021 Animals exhibit variations in any of the processes that lead to the termination of vital functions of a cell. Ced cell death abnormal C_elegans_phenotype_ontology WBPhenotype:0000729 cell death variant Animals exhibit variations in any of the processes that lead to the termination of vital functions of a cell. GO:0008219 WB:cab Animals exhibit variations in any processes that influence the programmed cell death pathway. Induction of the apoptotic pathway triggers the activity of proteolytic caspases, which in turn lead to the destruction of the cell. Ced apoptosis abnormal C_elegans_phenotype_ontology WBPhenotype:0000730 apoptosis variant Animals exhibit variations in any processes that influence the programmed cell death pathway. Induction of the apoptotic pathway triggers the activity of proteolytic caspases, which in turn lead to the destruction of the cell. GO:0006915 WB:WBPerson2021 Germ cells exhibit increased sensitivity to the effects of ion producing radiation compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000731 germ cell hypersensitive ionizing radiation Germ cells exhibit increased sensitivity to the effects of ion producing radiation compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in any process that involves the maintenance, biosynthesis or accumulation of DNA in the organism compared to control. DNA metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000732 DNA metabolism variant Variations in any process that involves the maintenance, biosynthesis or accumulation of DNA in the organism compared to control. WB:WBPerson2021 Any variation in the catalysis of a biochemical reaction compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). catalysis abnormal C_elegans_phenotype_ontology WBPhenotype:0000733 catalysis variant Any variation in the catalysis of a biochemical reaction compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). GO:0003824 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the hypodermal system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. hypodermal cell physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000734 hypodermal cell physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the hypodermal system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson712 Any variation in the regulated re-replication of DNA in the hypodermal cells during a single cell cycle, compared to control. endoreduplication of hypodermal nuclei abnormal C_elegans_phenotype_ontology WBPhenotype:0000735 endoreduplication of hypodermal nuclei variant Any variation in the regulated re-replication of DNA in the hypodermal cells during a single cell cycle, compared to control. GO:0042023 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the process by which their cells digest parts of their own cytoplasm, compared to control. autophagy abnormal C_elegans_phenotype_ontology WBPhenotype:0000736 autophagy variant Animals exhibit variations in the process by which their cells digest parts of their own cytoplasm, compared to control. GO:0006914 WB:WBPerson712 Germ cells fail to respond to the dosage of ion producing radiation that elicits a response in control animals. Alternatively, germ cells require a higher dosage or a longer exposure to ion producing radiation to elicit the same response as control animals. C_elegans_phenotype_ontology WBPhenotype:0000737 germ cell resistant ionizing radiation Germ cells fail to respond to the dosage of ion producing radiation that elicits a response in control animals. Alternatively, germ cells require a higher dosage or a longer exposure to ion producing radiation to elicit the same response as control animals. WB:WBPerson2021 WB:WBPerson557 The response to a change in the environment is altered compared to control. organism environmental stimulus response abnormal C_elegans_phenotype_ontology WBPhenotype:0000738 organism environmental stimulus response variant The response to a change in the environment is altered compared to control. WB:cab Variations in the activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism, compared to control. DNA damage response abnormal C_elegans_phenotype_ontology WBPhenotype:0000739 DNA damage response variant Variations in the activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism, compared to control. GO:0006974 WB:WBPerson2021 Cells of the animals exhibit variations in the initiation, progression or exit from the biochemical and morphological processes that occur during successive replication or nuclear replication events from that observed for control animals. cell cycle abnormal C_elegans_phenotype_ontology WBPhenotype:0000740 cell cycle variant Cells of the animals exhibit variations in the initiation, progression or exit from the biochemical and morphological processes that occur during successive replication or nuclear replication events from that observed for control animals. GO:0007049 WB:WBPerson557 WB:WBPerson712 Mitotic cells exhibit variations in the execution of cell-cycle arrest in response to DNA damage. DNA damage checkpoint abnormal C_elegans_phenotype_ontology WBPhenotype:0000741 DNA damage checkpoint variant Mitotic cells exhibit variations in the execution of cell-cycle arrest in response to DNA damage. WB:WBPaper00029085 WB:WBPerson2021 Variations in the process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents, compared to control. DNA recombination abnormal C_elegans_phenotype_ontology WBPhenotype:0000742 DNA recombination variant Variations in the process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents, compared to control. GO:0006310 WB:WBPerson2021 Animals exhibit variations in their response to gene silencing triggered by double stranded RNA (RNAi), compared to control. Rde RNAi response abnormal C_elegans_phenotype_ontology WBPhenotype:0000743 RNAi response variant Animals exhibit variations in their response to gene silencing triggered by double stranded RNA (RNAi), compared to control. GO:0016246 WB:WBPerson2021 Animals exhibit variations in the silencing of endogenous genes after introduction of repetitive exogenous cognate DNA compared to control. transgene induced cosuppression abnormal C_elegans_phenotype_ontology WBPhenotype:0000744 transgene induced cosuppression variant Animals exhibit variations in the silencing of endogenous genes after introduction of repetitive exogenous cognate DNA compared to control. WB:WBPaper00025139 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the activity of endogenous transposons compared to control. In C. elegans transposon activity is often measured by the rate of reversion of mutations induced by transposon insertions. transposon silencing abnormal C_elegans_phenotype_ontology WBPhenotype:0000745 transposon silencing variant Animals exhibit variations in the activity of endogenous transposons compared to control. In C. elegans transposon activity is often measured by the rate of reversion of mutations induced by transposon insertions. GO:0000335 WB:WBPaper00031962 WB:WBPerson712 Any variation that alters the physical partitioning and separation of a cell into daughter cells compared to control. cell division abnormal C_elegans_phenotype_ontology WBPhenotype:0000746 cell division variant Any variation that alters the physical partitioning and separation of a cell into daughter cells compared to control. GO:0051301 WB:WBPerson2021 Any defects in the muscle contractions that control feeding. Contractions are necessary for bacterial uptake from the surrounding environment. C_elegans_phenotype_ontology WBPhenotype:0000747 pharyngeal contraction defective Any defects in the muscle contractions that control feeding. Contractions are necessary for bacterial uptake from the surrounding environment. WB:WBPaper00001696 Symmetric (PAR-like) divisions or excessive posterior displacement (zyg-8 like phenotypes). Emb C_elegans_phenotype_ontology WBPhenotype:0000748 asymmetric cell division defective early emb Symmetric (PAR-like) divisions or excessive posterior displacement (zyg-8 like phenotypes). WB:cab WB:cgc7141 Variations in the progression of an embryo over time, from zygote formation to hatching compared to control. embryonic development abnormal C_elegans_phenotype_ontology developmental defects detected in embryos WBPhenotype:0000749 embryonic development variant Variations in the progression of an embryo over time, from zygote formation to hatching compared to control. GO:0009790 WB:WBPerson2021 Variations in the progression of a larva over time, from its formation to the mature structure compared to control. The larva is the early, immature form of an animal between hatching and adulthood. larval development abnormal C_elegans_phenotype_ontology WBPhenotype:0000750 larval development variant Variations in the progression of a larva over time, from its formation to the mature structure compared to control. The larva is the early, immature form of an animal between hatching and adulthood. GO:0002164 WB:WBPerson2021 Variations in the progression of a newly hatched animal through the first larval molt compared to control. L1 larval development abnormal C_elegans_phenotype_ontology WBPhenotype:0000751 L1 larval development variant Variations in the progression of a newly hatched animal through the first larval molt compared to control. WB:WBPerson2021 Variations in the progression of the second larval stage compared to control. L2 larval development abnormal C_elegans_phenotype_ontology WBPhenotype:0000752 L2 larval development variant Variations in the progression of the second larval stage compared to control. WB:WBPerson557 Variations in the progression of the third larval stage compared to control. L3 larval development abnormal C_elegans_phenotype_ontology WBPhenotype:0000753 L3 larval development variant Variations in the progression of the third larval stage compared to control. WB:WBPerson557 Variations in the progression of the fourth larval stage compared to control. L4 larval development abnormal C_elegans_phenotype_ontology WBPhenotype:0000754 L4 larval development variant Variations in the progression of the fourth larval stage compared to control. WB:WBPerson557 Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L1 to L2 transition. L1 L2 molt abnormal C_elegans_phenotype_ontology L1 molt WBPhenotype:0000755 L1 L2 molt defect Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L1 to L2 transition. GO:0018996 Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L2 to L3 transition. L2 L3 molt abnormal C_elegans_phenotype_ontology L2 molt WBPhenotype:0000756 L2 L3 molt defect Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L2 to L3 transition. GO:0018996 Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L3 to L4 transition. L3 L4 molt abnormal C_elegans_phenotype_ontology L3 molt WBPhenotype:0000757 L3 L4 molt defect Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L3 to L4 transition. GO:0018996 Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L4 to adult transition. L4 adult molt abnormal C_elegans_phenotype_ontology L4 molt WBPhenotype:0000758 L4 adult molt defect Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L4 to adult transition. GO:0018996 Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubules and associated molecules that form between opposite poles of a eukaryotic cell during a cell cycle. Emb Spd C_elegans_phenotype_ontology WBPhenotype:0000759 Possible XP. spindle defective early emb Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubules and associated molecules that form between opposite poles of a eukaryotic cell during a cell cycle. GO:0007051 WB:WBPerson2021 The alignment of the spindle relative to other cellular structures in the cells of an embryo varies from that observed in control animals. Emb Spn C_elegans_phenotype_ontology WBPhenotype:0000760 spindle orientation defective early emb The alignment of the spindle relative to other cellular structures in the cells of an embryo varies from that observed in control animals. WB:WBPerson557 Early embryos exhibit defects in the placement or the alignment of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis. Emb Spo C_elegans_phenotype_ontology Spi WBPhenotype:0000761 spindle position orientation defective early emb Early embryos exhibit defects in the placement or the alignment of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis. WB:WBPerson2021 WB:WBPerson557 Early embryos exhibit defects in the placement of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis. Abs Emb C_elegans_phenotype_ontology WBPhenotype:0000762 Possible XP. spindle position defective early emb Early embryos exhibit defects in the placement of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis. GO:0051653 WB:WBPerson2021 WB:WBPerson557 Animals exhibit deviations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for an embryonic cell to carry out its normal function and activities or be able to perceive and respond to stimuli. embryonic cell physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000763 embryonic cell physiology variant Animals exhibit deviations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for an embryonic cell to carry out its normal function and activities or be able to perceive and respond to stimuli. GO:0009987 WB:WBPerson557 Variations in the processes that are carried out at in the embryo which results in its formation or the arrangement of constituent parts, compared to control. embryonic cell organization biogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0000764 embryonic cell organization biogenesis variant Variations in the processes that are carried out at in the embryo which results in its formation or the arrangement of constituent parts, compared to control. WB:WBPerson2021 WB:WBPerson557 The embryos exhibit defects in the cell cycle process whereby the distance is lengthened between poles of the spindle. Emb C_elegans_phenotype_ontology WBPhenotype:0000765 Possible XP. spindle elongation integrity defective early emb The embryos exhibit defects in the cell cycle process whereby the distance is lengthened between poles of the spindle. GO:0051231 WB:WBPerson2021 WB:cab WB:cgc7141 Any variation in the rotation of the centrosome-pronuclear complex after its migration toward the center of the embryo, compared to control. Rot centrosome pair and associated pronuclear rotation abnormal C_elegans_phenotype_ontology WBPhenotype:0000766 Possible XP. centrosome pair and associated pronuclear rotation variant Any variation in the rotation of the centrosome-pronuclear complex after its migration toward the center of the embryo, compared to control. WB:WBPaper00004895 WB:WBPerson2021 WB:WBPerson557 Sparse or enlarged yolk granules. Emb C_elegans_phenotype_ontology WBPhenotype:0000767 integrity of membranous organelles defective early emb Sparse or enlarged yolk granules. WB:WBPaper00025054 WB:cab Areas devoid of yolk granules throughout the embryo. Emb cytoplasmic structure abnormal C_elegans_phenotype_ontology Aberrant Cytoplasmic Structure cellular structure disorganized WBPhenotype:0000768 cytoplasmic structure defective early emb Areas devoid of yolk granules throughout the embryo. WB:cab WB:cgc7141 Embryos exhibit defects in the form, structure or composition of any cellular contents (excluding plasma membrane and nucleus), compared to control embryos. Emb C_elegans_phenotype_ontology WBPhenotype:0000769 cytoplasmic appearance defective early emb Embryos exhibit defects in the form, structure or composition of any cellular contents (excluding plasma membrane and nucleus), compared to control embryos. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the appearance of embryonic cells compared to control. embryonic cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000770 embryonic cell morphology variant Animals exhibit variations in the appearance of embryonic cells compared to control. WB:cab Centrosomes detach from the male pronucleus. Emb C_elegans_phenotype_ontology WBPhenotype:0000771 centrosome attachment defective early emb Centrosomes detach from the male pronucleus. WB:cab WB:cgc7141 Daughter nuclei are deformed and stay close to central cortex, cytokinesis defects. Emb C_elegans_phenotype_ontology WBPhenotype:0000772 sister chromatid segregation defective early emb Daughter nuclei are deformed and stay close to central cortex, cytokinesis defects. WB:cab WB:cgc7141 Any variation in the processes that regulate the apportionment of chromosomes to each of two daughter cells compared to control. chromosome segregation abnormal C_elegans_phenotype_ontology WBPhenotype:0000773 chromosome segregation variant Any variation in the processes that regulate the apportionment of chromosomes to each of two daughter cells compared to control. GO:0007059 WB:WBPerson2021 WB:WBPerson557 WB:kmva Any variation in the processes that govern the generation and maintenance of gametes compared to control. gametogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0000774 gametogenesis variant Any variation in the processes that govern the generation and maintenance of gametes compared to control. GO:0007276 WB:WBPerson2021 Variations in the specialized nuclear and cytoplasmic divisions of a single diploid cell, whose specific outcome is the formation of four haploid daughter cells compared to control. Meiosis occurs during the formation of gametes. meiosis abnormal C_elegans_phenotype_ontology Mei germ cell meiosis abnormal germ cell meiosis variant WBPhenotype:0000775 meiosis variant Variations in the specialized nuclear and cytoplasmic divisions of a single diploid cell, whose specific outcome is the formation of four haploid daughter cells compared to control. Meiosis occurs during the formation of gametes. GO:0051321 WB:WBPerson2021 Male and female PNs not visible; embryo often fills egg shell completely. Emb passage through meiosis abnormal C_elegans_phenotype_ontology WBPhenotype:0000776 passage through meiosis defective early emb Male and female PNs not visible; embryo often fills egg shell completely. WB:cab WB:cgc71441 Unextruded or resorbed polar body(ies) leading to an extra PNs in P0 and/or extra karyomeres in AB/P1. Emb polar body extrusion abnormal C_elegans_phenotype_ontology WBPhenotype:0000777 polar body extrusion defective early emb Unextruded or resorbed polar body(ies) leading to an extra PNs in P0 and/or extra karyomeres in AB/P1. WB:cab WB:cgc7141 Animals are unable to ingest nutrients at a rate similar to control animals. C_elegans_phenotype_ontology WBPhenotype:0000778 feeding inefficient Animals are unable to ingest nutrients at a rate similar to control animals. WB:WBPaper00032342 WB:WBPerson712 Cessation of development during the final stages of embryogenesis. In C. elegans, this stage normally occurs 620-800 min after the first cleavage at 20C and is the stage after elongation. C_elegans_phenotype_ontology WBPhenotype:0000779 late embryonic arrest Cessation of development during the final stages of embryogenesis. In C. elegans, this stage normally occurs 620-800 min after the first cleavage at 20C and is the stage after elongation. WB:WBPerson101 Animals rotate back and forth around their longitudinal axes. C_elegans_phenotype_ontology WBPhenotype:0000780 shaker Animals rotate back and forth around their longitudinal axes. WB:cab WB:cgc914 Any variation in the extremely thin elongated cytoplasmic filament, usually composed principally of actin protein to form a myofilament lattice, as in muscle cells compared to control (Wormatlas). thin filament abnormal C_elegans_phenotype_ontology thin filament variant WBPhenotype:0000781 body wall muscle thin filament variant Any variation in the extremely thin elongated cytoplasmic filament, usually composed principally of actin protein to form a myofilament lattice, as in muscle cells compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of a robust elongated cytoplasmic filament composed principally of myosin protein compared to control animals. In C. elegans, thick filaments also contain paramyosin and twitchin (Wormatlas). thick filament abnormal C_elegans_phenotype_ontology thick filament variant WBPhenotype:0000782 body wall muscle thick filament variant Animals exhibit variations in the form, structure or composition of a robust elongated cytoplasmic filament composed principally of myosin protein compared to control animals. In C. elegans, thick filaments also contain paramyosin and twitchin (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals lack the planar structure within the muscle sarcomere which lies midway within the thick filament (A) band, attaching to the plasma membrane at its base and running up towards the inward surface of the myofilament lattice, compared to control animals (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000783 M line absent Animals lack the planar structure within the muscle sarcomere which lies midway within the thick filament (A) band, attaching to the plasma membrane at its base and running up towards the inward surface of the myofilament lattice, compared to control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Males exhibit variations in the time of onset or duration of the fertile period owing to differences in sperm competence and/or function compared to control animals. male fertility abnormal C_elegans_phenotype_ontology WBPhenotype:0000784 male fertility variant Males exhibit variations in the time of onset or duration of the fertile period owing to differences in sperm competence and/or function compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a particular body part compared to control animals. body part pigmentation abnormal C_elegans_phenotype_ontology WBPhenotype:0000785 body part pigmentation variant Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a particular body part compared to control animals. WB:WBPerson557 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency along a particular body axis compared to control. body axis pigmentation abnormal C_elegans_phenotype_ontology WBPhenotype:0000786 body axis pigmentation variant Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency along a particular body axis compared to control. WB:WBPerson557 Animals have decreased accumulation or expression of biochromes or any other substances that causes increased translucency of the posterior body axis compared to control. C_elegans_phenotype_ontology WBPhenotype:0000787 posterior pale Animals have decreased accumulation or expression of biochromes or any other substances that causes increased translucency of the posterior body axis compared to control. WB:WBPerson557 Animals have decreased accumulation or expression of biochromes or any other substances that causes increased translucency of the anterior body axis compared to control. C_elegans_phenotype_ontology WBPhenotype:0000788 anterior pale Animals have decreased accumulation or expression of biochromes or any other substances that causes increased translucency of the anterior body axis compared to control. WB:WBPerson557 Animals respond to fluoxetine at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000789 fluoxetine hypersensitive Animals respond to fluoxetine at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of fluoxetine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000790 fluoxetine resistant Animals fail to respond to the concentration of fluoxetine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 The nose of an animal fails to respond to the concentration of fluoxetine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000791 nose resistant to fluoxetine The nose of an animal fails to respond to the concentration of fluoxetine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals exhibit variations in the form, structure or composition of the anatomy contained in the anterior region, compared to control animals. anterior region morphology variant anterior body morphology abnormal anterior region morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000792 anterior body morphology variant Animals exhibit variations in the form, structure or composition of the anatomy contained in the anterior region, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of the anatomy contained in the posterior region, compared to control animals. WBPhenotype:0001490 posterior region morphology variant posterior body morphology abnormal posterior region morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000793 posterior body morphology variant Animals exhibit variations in the form, structure or composition of the anatomy contained in the posterior region, compared to control animals. WB:WBPerson2021 WB:WBPerson557 The posterior part of the worm exhibits a reduced girth compared to a control animal of the same developmental stage. C_elegans_phenotype_ontology WBPhenotype:0000794 posterior body thin The posterior part of the worm exhibits a reduced girth compared to a control animal of the same developmental stage. WB:WBPerson2021 WB:WBPerson557 Variations in the specific actions or reactions of one of the longitudinal axes of the extended body of the worm in response to external or internal stimuli compared to that observed in control animals (Wormatlas). body axis behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000795 body axis behavior variant Variations in the specific actions or reactions of one of the longitudinal axes of the extended body of the worm in response to external or internal stimuli compared to that observed in control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The movement of the posterior part of the worm is not coordinated with the rest of the body. C_elegans_phenotype_ontology WBPhenotype:0000796 posterior body uncoordinated The movement of the posterior part of the worm is not coordinated with the rest of the body. WB:cab Variations in the specific actions or reactions of the longitudinal axis that spans from the midpoint to the tip of the tail of an animal in response to external or internal stimuli compared to that observed in control animals (Wormatlas). posterior body behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000797 posterior body behavior variant Variations in the specific actions or reactions of the longitudinal axis that spans from the midpoint to the tip of the tail of an animal in response to external or internal stimuli compared to that observed in control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the specific actions or reactions of the longitudinal axis that spans from the midpoint to the tip of the head of an animal in response to external or internal stimuli compared to that observed in control animals (Wormatlas). anterior body behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000798 anterior body behavior variant Variations in the specific actions or reactions of the longitudinal axis that spans from the midpoint to the tip of the head of an animal in response to external or internal stimuli compared to that observed in control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the progression of an animal's anatomy contained in the anterior region over time, compared to control animals. anterior region development abnormal C_elegans_phenotype_ontology WBPhenotype:0000799 anterior region development variant Variations in the progression of an animal's anatomy contained in the anterior region over time, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of an animal's anatomy contained in the posterior region over time, compared to control animals. posterior region development abnormal C_elegans_phenotype_ontology WBPhenotype:0000800 posterior region development variant Variations in the progression of an animal's anatomy contained in the posterior region over time, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of an animal's anatomy contained in the ventral region over time, compared to control animals. ventral region development abnormal C_elegans_phenotype_ontology WBPhenotype:0000801 ventral region development variant Variations in the progression of an animal's anatomy contained in the ventral region over time, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of an animal's anatomy contained in the dorsal region over time, compared to control animals. dorsal region development abnormal C_elegans_phenotype_ontology WBPhenotype:0000802 dorsal region development variant Variations in the progression of an animal's anatomy contained in the dorsal region over time, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of the anterior end of the animal over time from an initial condition to a later condition compared to control animals. head development abnormal C_elegans_phenotype_ontology WBPhenotype:0000803 head development variant Variations in the progression of the anterior end of the animal over time from an initial condition to a later condition compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of the overall structure or appearance of the animal over time from an initial condition to a later condition compared to control animals. body development abnormal C_elegans_phenotype_ontology WBPhenotype:0000804 body development variant Variations in the progression of the overall structure or appearance of the animal over time from an initial condition to a later condition compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the process whose specific outcome is the progression of the tail over time, from its formation to the mature structure, compared to control. The tail includes the posterior region that spans from the rectum to the end. tail development abnormal C_elegans_phenotype_ontology WBPhenotype:0000805 tail development variant Any variation in the process whose specific outcome is the progression of the tail over time, from its formation to the mature structure, compared to control. The tail includes the posterior region that spans from the rectum to the end. WB:WBPerson2021 Hermaphrodites exhibit variations in the time of onset or duration of the fertile period, or variations in the production of viable offspring, including number and state of fertilized eggs laid, compared to controls. hermaphrodite fertility abnormal C_elegans_phenotype_ontology WBPhenotype:0000806 hermaphrodite fertility variant Hermaphrodites exhibit variations in the time of onset or duration of the fertile period, or variations in the production of viable offspring, including number and state of fertilized eggs laid, compared to controls. WB:WBPerson712 The descendants of the G1 or G2 exhibit altered developmental programs compared to their counterparts in control animals. G lineages abnormal C_elegans_phenotype_ontology WBPhenotype:0000807 G lineages variant The descendants of the G1 or G2 exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of the K precursor cell exhibit altered developmental programs compared to their counterparts in control animals. K lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000808 K lineage variant The descendants of the K precursor cell exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of a male specific precursor cell exhibit altered developmental programs compared to their counterparts in control animals. male specific lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000809 male specific lineage variant The descendants of a male specific precursor cell exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 Any variation in the progression of a blast cell (precursor cell) over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. blast cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000810 blast cell development variant Any variation in the progression of a blast cell (precursor cell) over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. WB:WBPerson2021 Any variation in the progression of an epithelial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. epithelial cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000811 epithelial cell development variant Any variation in the progression of an epithelial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. WB:WBPerson2021 Variations in the progression of the immature germ cell over time, from its formation from precursors to the mature structure (gamete) compared to control. germ cell development abnormal C_elegans_phenotype_ontology germline development abnormal WBPhenotype:0000812 germ cell development variant Variations in the progression of the immature germ cell over time, from its formation from precursors to the mature structure (gamete) compared to control. GO:0007281 WB:WBPerson2021 Any variation in the progression of a gland cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. gland cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000813 gland cell development variant Any variation in the progression of a gland cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. WB:WBPerson2021 Any variation in the progression of a marginal cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. A marginal cell is a pharyngeal cell that connects the basement membrane to the apices of the triangle-shaped pharyngeal lumen. marginal cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000814 marginal cell development variant Any variation in the progression of a marginal cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. A marginal cell is a pharyngeal cell that connects the basement membrane to the apices of the triangle-shaped pharyngeal lumen. WB:WBPerson2021 Any variation in the progression of a muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. muscle cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000815 muscle cell development variant Any variation in the progression of a muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. WB:WBPerson2021 Variations in the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. neuron development abnormal C_elegans_phenotype_ontology WBPhenotype:0000816 neuron development variant Variations in the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. GO:0048666 WB:WBPerson2021 Variations in the progression of the epithelial cells that form the interface between the uterus and the vulva (likely via a multilayered set of flaps) over time from an initial condition to a later condition compared to control animals (Wormatlas). uterine vulval cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000817 uterine vulval cell development variant Variations in the progression of the epithelial cells that form the interface between the uterus and the vulva (likely via a multilayered set of flaps) over time from an initial condition to a later condition compared to control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Activity characteristic of an adult worm is altered compared to control. adult behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000818 adult behavior variant Activity characteristic of an adult worm is altered compared to control. WB:cab Behavior characteristic of postembryonic stage(s) is altered compared to control. postembryonic behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000819 postembryonic behavior variant Behavior characteristic of postembryonic stage(s) is altered compared to control. WB:cab Activity characteristic of an embryo is altered compared to control. embryonic behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000820 embryonic behavior variant Activity characteristic of an embryo is altered compared to control. WB:cab Animals exhibit variations in sex-specific behaviors compared to control. sexually dimorphic behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000821 sexually dimorphic behavior variant Animals exhibit variations in sex-specific behaviors compared to control. WB:WBPerson557 Any variation in the processes that govern the sexually dimorphic development of germline or somatic tissue compared to control. sex determination abnormal C_elegans_phenotype_ontology sex specific development abnormal WBPhenotype:0000822 sex determination variant Any variation in the processes that govern the sexually dimorphic development of germline or somatic tissue compared to control. WB:kmva Nuclear divisions in the germ line are either expanded are reduced compared to control. Glp germ line proliferation abnormal germline proliferation abnormal C_elegans_phenotype_ontology germ cell proliferation abnormal WBPhenotype:0000823 germline proliferation variant Nuclear divisions in the germ line are either expanded are reduced compared to control. WB:cab The descendants of an embryonic precursor cell exhibit altered developmental programs compared to their counterparts in control animals. embryonic cell lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000824 embryonic cell lineage variant The descendants of an embryonic precursor cell exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of a postembryonic precursor cell exhibit altered developmental programs compared to their counterparts in control animals. postembryonic cell lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000825 postembryonic cell lineage variant The descendants of a postembryonic precursor cell exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of H1 or H2 cells exhibit altered developmental programs compared to their counterparts in control animals. H lineages abnormal C_elegans_phenotype_ontology WBPhenotype:0000826 H lineages variant The descendants of H1 or H2 cells exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of any of the V precursor cells (V1-V6) exhibit altered developmental programs compared to their counterparts in control animals. V lineages abnormal C_elegans_phenotype_ontology WBPhenotype:0000827 V lineages variant The descendants of any of the V precursor cells (V1-V6) exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of TL or TR cells exhibit altered developmental programs compared to their counterparts in control animals. T lineages abnormal C_elegans_phenotype_ontology WBPhenotype:0000828 T lineages variant The descendants of TL or TR cells exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of Q L or QR cells exhibit altered developmental programs compared to their counterparts in control animals. Q lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000829 Q lineage variant The descendants of Q L or QR cells exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of the B cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals. B lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000830 B lineage variant The descendants of the B cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of the Y cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals. Y lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000831 Y lineage variant The descendants of the Y cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of the C blastomere exhibit altered developmental programs compared to their counterparts in control animals. C lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000832 C lineage variant The descendants of the C blastomere exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPaper00001584 WB:WBPerson2021 The descendants of the U cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals. U lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000833 U lineage variant The descendants of the U cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of the E blastomere exhibit altered developmental programs compared to their counterparts in control animals. E lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000834 E lineage variant The descendants of the E blastomere exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPaper00002870 WB:WBPerson2021 The descendants of the F cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals. F lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000835 F lineage variant The descendants of the F cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of a gonadal precursor cell exhibit altered developmental programs compared to their counterparts in control animals. gonadal lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000836 gonadal lineage variant The descendants of a gonadal precursor cell exhibit altered developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of a gonadal precursor cell exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals. hermaphrodite gonadal lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000837 hermaphrodite gonadal lineage variant The descendants of a gonadal precursor cell exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals. WB:WBPerson2021 The descendants of a gonadal precursor cell exhibit altered developmental programs in the male compared to their counterparts in control animals. male gonadal lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000838 male gonadal lineage variant The descendants of a gonadal precursor cell exhibit altered developmental programs in the male compared to their counterparts in control animals. WB:WBPerson2021 Z1 descendants exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals. Z1 hermaphrodite lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000839 Z1 hermaphrodite lineage variant Z1 descendants exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals. WB:WBPerson2021 Z4 descendants exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals. Z4 hermaphrodite lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000840 Z4 hermaphrodite lineage variant Z4 descendants exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals. WB:WBPerson2021 Z1 descendents exhibit altered developmental programs in the male compared to their counterparts in control animals. Z1 male lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000841 Z1 male lineage variant Z1 descendents exhibit altered developmental programs in the male compared to their counterparts in control animals. WB:WBPerson2021 Z4 descendants exhibit altered developmental programs in the male compared to their counterparts in control animals. Z4 male lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000842 Z4 male lineage variant Z4 descendants exhibit altered developmental programs in the male compared to their counterparts in control animals. WB:WBPerson2021 The number of cross progeny sired by males is reduced compared to control. C_elegans_phenotype_ontology WBPhenotype:0000843 male mating efficiency reduced The number of cross progeny sired by males is reduced compared to control. WB:WBPaper00000179 WB:WBPaper00000608 WB:WBPerson557 Pharyngeal pumping is not influenced by serotonin treatment in the same manner as control animals. serotonin induced pumping abnormal C_elegans_phenotype_ontology WBPhenotype:0000844 serotonin induced pumping variant Pharyngeal pumping is not influenced by serotonin treatment in the same manner as control animals. WB:WBPerson2021 Animals exhibit variations in the response to the addition of levamisole compared to that observed in control animals. Levamisole is a cholinergic agonist. levamisole response abnormal C_elegans_phenotype_ontology tetramisole response abnormal WBPhenotype:0000845 levamisole response variant Animals exhibit variations in the response to the addition of levamisole compared to that observed in control animals. Levamisole is a cholinergic agonist. WB:WBPerson557 Animals exhibit variations in any physical or chemical process in the region of the vesicle-filled varicosities of the synapse compared to control. presynaptic region physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000846 presynaptic region physiology variant Animals exhibit variations in any physical or chemical process in the region of the vesicle-filled varicosities of the synapse compared to control. WB:WBPerson2021 WB:WBPerson557 Animals display variations in the distribution of the constituents that make up the synaptic machinery such as those required for priming, docking or fusion of vesicles at the active zone, compared to that observed in control animals. presynaptic component localization abnormal C_elegans_phenotype_ontology synaptic component localization abnormal synaptic machinery localization abnormal WBPhenotype:0000847 presynaptic component localization variant Animals display variations in the distribution of the constituents that make up the synaptic machinery such as those required for priming, docking or fusion of vesicles at the active zone, compared to that observed in control animals. WB:WBPaper00027305 WB:WBPerson712 The developmental progression of an animal over time, from its formation to its mature structure is delayed compared to control. C_elegans_phenotype_ontology WBPhenotype:0000848 developmental delay The developmental progression of an animal over time, from its formation to its mature structure is delayed compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in any physical or chemical process required for an amphid to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. amphid physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000849 amphid physiology variant Animals exhibit variations in any physical or chemical process required for an amphid to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson557 Animal does not respond to stroking in the anterior body region with a hair or similar fiber compared to control. In C. elegans, the anterior region is defined as the body region that lies between the posterior bulb of the pharynx and the vulva. C_elegans_phenotype_ontology touch insensitive anterior body WBPhenotype:0000850 touch resistant anterior body Animal does not respond to stroking in the anterior body region with a hair or similar fiber compared to control. In C. elegans, the anterior region is defined as the body region that lies between the posterior bulb of the pharynx and the vulva. WB:WBPaper00000502 WB:WBPaper00001705 WB:WBPerson557 Animals exhibit variations in any physical or chemical process required for the ciliated neuron to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. ciliated neuron physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000851 ciliated neuron physiology variant Animals exhibit variations in any physical or chemical process required for the ciliated neuron to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson712 Variations in the progression of a free-floating spherical cell lying in the pseudocoelomic cavity of animals that can endocytose many compounds, possibly for immune surveillance, over time from an initial condition to a later condition compared to control animals. coelomocyte development abnormal C_elegans_phenotype_ontology WBPhenotype:0000852 coelomocyte development variant Variations in the progression of a free-floating spherical cell lying in the pseudocoelomic cavity of animals that can endocytose many compounds, possibly for immune surveillance, over time from an initial condition to a later condition compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum, compared to control. intraflagellar transport abnormal C_elegans_phenotype_ontology IFT abnormal WBPhenotype:0000853 intraflagellar transport variant Variations in the bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum, compared to control. GO:0042073 WB:WBPerson2021 Bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is disrupted. C_elegans_phenotype_ontology ift defective WBPhenotype:0000854 intraflagellar transport defective Bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is disrupted. WB:WBPerson2021 Variations in the progression of the fluid-filled space which separates the body wall from internal organs over time from its initial formation to its mature form compared to control (Wormatlas). pseudocoelom development abnormal C_elegans_phenotype_ontology WBPhenotype:0000855 pseudocoelom development variant Variations in the progression of the fluid-filled space which separates the body wall from internal organs over time from its initial formation to its mature form compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of a gland cell of the secretory-excretory system over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. excretory gland cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000856 excretory gland cell development variant Any variation in the progression of a gland cell of the secretory-excretory system over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. WB:WBPerson2021 Variations in the progression of a protokidney cell with an internal lumen that is suggested to collect and secrete salt solutions outward via the excretory sinus, over time from an initial condition to a later condition compared to control animals. excretory cell development abnormal C_elegans_phenotype_ontology excretory canal cell development abnormal WBPhenotype:0000857 excretory cell development variant Variations in the progression of a protokidney cell with an internal lumen that is suggested to collect and secrete salt solutions outward via the excretory sinus, over time from an initial condition to a later condition compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of an interfacial epithelial cell which forms a lumen to receive the outflow of the excretory gland and excretory canal cells, over time from an initial condition to a later condition compared to control animals. excretory duct cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000858 excretory duct cell development variant Variations in the progression of an interfacial epithelial cell which forms a lumen to receive the outflow of the excretory gland and excretory canal cells, over time from an initial condition to a later condition compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of an interfacial epithelial cell which links excretory duct to hypodermis, over time from an initial condition to a later condition compared to control animals. excretory socket cell development abnormal C_elegans_phenotype_ontology excretory pore cell development abnormal WBPhenotype:0000859 excretory socket cell development variant Variations in the progression of an interfacial epithelial cell which links excretory duct to hypodermis, over time from an initial condition to a later condition compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of muscle cells that lack transverse striations in its constituent fibers and are almost always involuntary, over time from an initial condition to a later condition compared to control animals. nonstriated muscle development abnormal C_elegans_phenotype_ontology WBPhenotype:0000860 nonstriated muscle development variant Variations in the progression of muscle cells that lack transverse striations in its constituent fibers and are almost always involuntary, over time from an initial condition to a later condition compared to control animals. GO:0051145 WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the principal muscle cell type whose contractile activity generates body motion in the nematode over time compared to control. In C. elegans they consist of 95 unfused cells in the adult organized into four muscle quadrants. Their sarcomeres are obliquely striated and lie lengthwise along the body wall (Wormatlas). body wall muscle development abnormal body wall muscle cell development abnormal body wall muscle cell development variant C_elegans_phenotype_ontology muscle belly development abnormal somatic muscle development abnormal striated muscle development abnormal WBPhenotype:0000861 body wall muscle development variant Any variation in the progression of the principal muscle cell type whose contractile activity generates body motion in the nematode over time compared to control. In C. elegans they consist of 95 unfused cells in the adult organized into four muscle quadrants. Their sarcomeres are obliquely striated and lie lengthwise along the body wall (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Worms appears turgid or swollen as a result of an excess number of eggs being retained in the uterus. C_elegans_phenotype_ontology WBPhenotype:0000862 bloated Worms appears turgid or swollen as a result of an excess number of eggs being retained in the uterus. WB:WBPerson2021 WB:WBPerson557 Males exhibit a reduction in the production of new individuals owing to defects in sperm competence and/or function compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000863 male fertility reduced Males exhibit a reduction in the production of new individuals owing to defects in sperm competence and/or function compared to control animals. WB:WBPerson2021 WB:WBPerson557 Cessation of development during the initial period of elongation. In C. elegans, this period refers to the conversion of the bean-shaped embryo into the two-fold- shaped embryo. C_elegans_phenotype_ontology WBPhenotype:0000864 early elongation arrest Cessation of development during the initial period of elongation. In C. elegans, this period refers to the conversion of the bean-shaped embryo into the two-fold- shaped embryo. WB:WBPaper00027244 Animals exhibit variations in any physical or chemical process required for a amphid sheath cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. amphid sheath cell physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000865 amphid sheath cell physiology variant Animals exhibit variations in any physical or chemical process required for a amphid sheath cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson557 Germ cells fail to undergo meiotic differentiation to form mature gametes. C_elegans_phenotype_ontology WBPhenotype:0000866 germ cell arrest Germ cells fail to undergo meiotic differentiation to form mature gametes. WB:WBPerson2021 WB:WBPerson557 Cessation of development during any stage occurring after fertilization and until hatching compared to control. C_elegans_phenotype_ontology WBPhenotype:0000867 embryonic arrest Cessation of development during any stage occurring after fertilization and until hatching compared to control. WB:WBPerson712 All parts of the animal are immobilized except for the head. C_elegans_phenotype_ontology WBPhenotype:0000868 paralyzed body All parts of the animal are immobilized except for the head. WB:cab OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000869 obsolete mitochondria morphology variant muscle true OBSOLETE. WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000870 obsolete mitochondria morphology variant epithelial true OBSOLETE. WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000871 obsolete connected mitochondria epithelial true OBSOLETE. WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000872 obsolete connected mitochodria muscle true OBSOLETE. WB:WBPerson557 Mitotic cells exhibit variations during the passage through a cell cycle control point late in the G1 phase of the mitotic cell cycle just before entry into S phase, compared to control cells. G1 checkpoint abnormal C_elegans_phenotype_ontology WBPhenotype:0000873 G1 checkpoint variant Mitotic cells exhibit variations during the passage through a cell cycle control point late in the G1 phase of the mitotic cell cycle just before entry into S phase, compared to control cells. GO:0007089 WB:WBPerson557 WB:WBPerson712 Mitotic cells exhibit variations during the passage through a cell cycle control point late in the G2 phase of the mitotic cell cycle just before entry into M phase, nuclear division, compared to control cells. G2 checkpoint abnormal C_elegans_phenotype_ontology WBPhenotype:0000874 G2 checkpoint variant Mitotic cells exhibit variations during the passage through a cell cycle control point late in the G2 phase of the mitotic cell cycle just before entry into M phase, nuclear division, compared to control cells. GO:0000075 WB:WBPerson557 WB:WBPerson712 Mitotic cells exhibit variations during the passage through a cell cycle control point late in the S phase of the mitotic cell cycle, which ensures DNA replication is complete, compared to control cells. S phase checkpoint abnormal C_elegans_phenotype_ontology WBPhenotype:0000875 S phase checkpoint variant Mitotic cells exhibit variations during the passage through a cell cycle control point late in the S phase of the mitotic cell cycle, which ensures DNA replication is complete, compared to control cells. GO:0033314 WB:WBPerson712 Animals exhibit variations in their response to osmotic stress compared to that observed in control animals. organism osmotic stress response abnormal C_elegans_phenotype_ontology WBPhenotype:0000876 organism osmotic stress response variant Animals exhibit variations in their response to osmotic stress compared to that observed in control animals. WB:WBPerson557 Any variation in the progression of a sheath cell of the amphid sensillum over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. amphid sheath cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000877 amphid sheath cell development variant Any variation in the progression of a sheath cell of the amphid sensillum over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. WB:WBPerson2021 Any variation in the progression of a chemosensory neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. chemosensory neuron development abnormal C_elegans_phenotype_ontology WBPhenotype:0000878 chemosensory neuron development variant Any variation in the progression of a chemosensory neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. WB:WBPerson2021 Animals exhibit variations in the processes that are required to maintain the length of telomeric DNA from generation to generation compared to control. telomere length regulation abnormal C_elegans_phenotype_ontology WBPhenotype:0000879 telomere length regulation variant Animals exhibit variations in the processes that are required to maintain the length of telomeric DNA from generation to generation compared to control. GO:0032204 WB:WBPaper00031585 WB:WBPerson712 Any variation in the processes that influence the generation of neuronal extensions, that carry efferent (outgoing) action potentials from the cell body towards target cells compared to control. axon development abnormal C_elegans_phenotype_ontology axonogenesis abnormal WBPhenotype:0000880 axon development variant Any variation in the processes that influence the generation of neuronal extensions, that carry efferent (outgoing) action potentials from the cell body towards target cells compared to control. GO:0007409 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the placement of the microtuble-based dendritic projections in relation to the sensillum neuron, from that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000881 cilia mislocalized Animals exhibit variations in the placement of the microtuble-based dendritic projections in relation to the sensillum neuron, from that observed in control animals. WB:WBPerson712 Any variation in the processes that influence the generation of neuronal extensions, that carry afferent (incoming) action potentials towards the cell body compared to control. dendrite development abnormal C_elegans_phenotype_ontology WBPhenotype:0000882 dendrite development variant Any variation in the processes that influence the generation of neuronal extensions, that carry afferent (incoming) action potentials towards the cell body compared to control. GO:0016358 WB:WBPerson2021 Variations in the progression of the major zone of overlapping axons in the head, which encircles the isthmus of the pharynx to form a tightly packed ring-like structure on the outside of the pharynx, over time from an initial condition to a later condition compared to control animals. nerve ring development abnormal C_elegans_phenotype_ontology WBPhenotype:0000883 nerve ring development variant Variations in the progression of the major zone of overlapping axons in the head, which encircles the isthmus of the pharynx to form a tightly packed ring-like structure on the outside of the pharynx, over time from an initial condition to a later condition compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the structure or organization of either of a set of two ciliated wing neurons, AWBL or AWBR, of the amphid sensilla, compared to that observed in control animals. AWB morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000884 WBbt:0005671. AWB morphology variant Animals exhibit variations in the structure or organization of either of a set of two ciliated wing neurons, AWBL or AWBR, of the amphid sensilla, compared to that observed in control animals. WB:WBPaper00000938 WB:WBPerson712 Any variation in the removal of a cell corpse, by a neighboring cell or a phagocyte compared to control. engulfment abnormal C_elegans_phenotype_ontology phagocytosis abnormal WBPhenotype:0000885 engulfment variant Any variation in the removal of a cell corpse, by a neighboring cell or a phagocyte compared to control. GO:0043652 WB:WBPerson2021 Animals exhibit variations compared to a given control. Abnormal variant C_elegans_phenotype_ontology not WT not wildtype WBPhenotype:0000886 nematode phenotype Animals exhibit variations compared to a given control. WB:WBPerson557 Animals exhibit variations in hermaphrodite-specific behaviors compared to control. hermaphrodite behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000887 hermaphrodite behavior variant Animals exhibit variations in hermaphrodite-specific behaviors compared to control. WB:WBPerson557 Animals exhibit variations in male-specific behaviors compared to control. male behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000888 male behavior variant Animals exhibit variations in male-specific behaviors compared to control. WB:WBPerson557 Animals exhibit variations in any physical or chemical process required to carry out sex-specific activities or to be able to perceive and respond to sex-specific stimuli compared to control. sexually dimorphic physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000889 sexually dimorphic physiology variant Animals exhibit variations in any physical or chemical process required to carry out sex-specific activities or to be able to perceive and respond to sex-specific stimuli compared to control. WB:WBPerson557 Larva exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals. larval pigmentation abnormal C_elegans_phenotype_ontology WBPhenotype:0000890 larval pigmentation variant Larva exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals. WB:WBPerson557 Adult animals appear unusually transparent when compared to control. Clr C_elegans_phenotype_ontology WBPhenotype:0000891 clear adult Adult animals appear unusually transparent when compared to control. WB:WBPerson557 Nuclear divisions in the germ line of hermaphrodites are either expanded are reduced compared to control. hermaphrodite germline proliferation abnormal C_elegans_phenotype_ontology hermaphrodite germ cell proliferation abnormal hermaphrodite germ line proliferation abnormal WBPhenotype:0000892 hermaphrodite germline proliferation variant Nuclear divisions in the germ line of hermaphrodites are either expanded are reduced compared to control. WB:WBPerson2021 Nuclear divisions in the germ line of male animals are either expanded are reduced compared to control. male germline proliferation abnormal C_elegans_phenotype_ontology male germ cell proliferation abnormal male germ line proliferation abnormal WBPhenotype:0000893 male germline proliferation variant Nuclear divisions in the germ line of male animals are either expanded are reduced compared to control. WB:WBPerson2021 Variations in the ability of a relatively unspecialized cell to acquire the specialized features of a mature gamete compared to control. germ cell differentiation abnormal C_elegans_phenotype_ontology WBPhenotype:0000894 germ cell differentiation variant Variations in the ability of a relatively unspecialized cell to acquire the specialized features of a mature gamete compared to control. WB:WBPerson2021 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000895 obsolete spermatocyte germ cell differentiation abnormal true OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000896 obsolete oocyte germ cell differentiation abnormal true Variations in the material made up of fibers forming a framework and support structure for body tissues and organs compared to control. connective tissue abnormal C_elegans_phenotype_ontology WBPhenotype:0000897 connective tissue development variant Variations in the material made up of fibers forming a framework and support structure for body tissues and organs compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the morphological appearance of blast cells compared to control animals. blast cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000898 blast cell morphology variant Any variation in the morphological appearance of blast cells compared to control animals. WB:cab Any variation in the morphological appearance of epithelial cells compared to control animals. epithelial cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000899 epithelial cell morphology variant Any variation in the morphological appearance of epithelial cells compared to control animals. WB:WBPerson557 Any variation in the morphological appearance of germ cells compared to control animals. germ cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000900 germ cell morphology variant Any variation in the morphological appearance of germ cells compared to control animals. WB:cab Any variation in the morphological appearance of gland cells compared to control animals. gland cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000901 gland cell morphology variant Any variation in the morphological appearance of gland cells compared to control animals. WB:cab Any variation in the morphological appearance of intestinal cells compared to control animals. intestinal cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000902 intestinal cell morphology variant Any variation in the morphological appearance of intestinal cells compared to control animals. WB:cab Any variation in the morphological appearance of marginal cells compared to control animals. marginal cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000903 marginal cell morphology variant Any variation in the morphological appearance of marginal cells compared to control animals. WB:cab Any variation in the morphological appearance of muscle cells compared to control animals. muscle cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000904 muscle cell morphology variant Any variation in the morphological appearance of muscle cells compared to control animals. WB:cab Animals display variations in the structure or organization of components of the neuronal cell internal to the cell itself or in relation to the cellular environment compared to control. A neuron is a major cell type of nervous tissue specialized for transmission of information in the form of patterns of impulses. neuron morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000905 WBbt:0003679. neuron morphology variant Animals display variations in the structure or organization of components of the neuronal cell internal to the cell itself or in relation to the cellular environment compared to control. A neuron is a major cell type of nervous tissue specialized for transmission of information in the form of patterns of impulses. WB:WBPerson712 WB:cab Animals exhibit variations in the form, structure or composition of the epithelial cells that form the interface between the uterus and the vulva (likely via a multilayered set of flaps) compared to control animals (Wormatlas). uterine vulval cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000906 uterine vulval cell morphology variant Animals exhibit variations in the form, structure or composition of the epithelial cells that form the interface between the uterus and the vulva (likely via a multilayered set of flaps) compared to control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the structural appearance of the caudal opening of the rectum in the tail compared to control animals. anus morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000907 anus morphology variant Any variation in the structural appearance of the caudal opening of the rectum in the tail compared to control animals. WB:WBPerson557 Any variation in the structural appearance of the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus (cloacal opening) compared to control animals. WBPhenotype:0000343 cloaca morphology abnormal cloacal morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000908 cloacal morphology variant Any variation in the structural appearance of the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus (cloacal opening) compared to control animals. WB:WBPerson557 Any variation in the structure or appearance of the cells that form a narrow passage connecting the posterior bulb of the pharynx to the anterior intestine compared to control. In C. elegans this valve is composed of 3 pairs of cells each forming a flattened disc-like ring and is lined by a layer of cuticle (Wormatlas). pharyngeal intestinal valve morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000909 pharyngeal intestinal valve morphology variant Any variation in the structure or appearance of the cells that form a narrow passage connecting the posterior bulb of the pharynx to the anterior intestine compared to control. In C. elegans this valve is composed of 3 pairs of cells each forming a flattened disc-like ring and is lined by a layer of cuticle (Wormatlas). WB:WBPerson557 Any variation in the morphological appearance of the rectum compared to control animals. rectal morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000910 rectal morphology variant Any variation in the morphological appearance of the rectum compared to control animals. WB:WBPerson557 Any variation in the morphological appearance of coelomocytes compared to control animals. coelomocyte morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000911 coelomocyte morphology variant Any variation in the morphological appearance of coelomocytes compared to control animals. WB:WBPerson557 Any variation in the morphological appearance of pericellular components compared to control animals. pericellular component morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000912 pericellular component morphology variant Any variation in the morphological appearance of pericellular components compared to control animals. WB:WBPerson557 Any variation in the morphological appearance of the basal lamina compared to control animals. basal lamina morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000913 basal lamina morphology variant Any variation in the morphological appearance of the basal lamina compared to control animals. WB:WBPerson557 Animals exhibit variations in the form, structure or composition of a pair of large cells in the head that fuse to form a single gland whose contents are released into the excretory duct through a specialized secretory membrane, compared to control (Wormatlas). excretory gland cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000914 excretory gland cell morphology variant Animals exhibit variations in the form, structure or composition of a pair of large cells in the head that fuse to form a single gland whose contents are released into the excretory duct through a specialized secretory membrane, compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Adults show deficiencies in chroma resulting in increased translucency. C_elegans_phenotype_ontology WBPhenotype:0000915 pale adult Adults show deficiencies in chroma resulting in increased translucency. WB:WBPerson2021 WB:WBPerson557 Any variation in the morphological appearance of the excretory cell compared to control animals. excretory cell morphology abnormal C_elegans_phenotype_ontology excretory canal cell morphology abnormal WBPhenotype:0000916 excretory cell morphology variant Any variation in the morphological appearance of the excretory cell compared to control animals. WB:WBPerson557 Any variation in the morphological appearance of the excretory duct cell compared to control animals. excretory duct cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000917 excretory duct cell morphology variant Any variation in the morphological appearance of the excretory duct cell compared to control animals. WB:WBPerson557 Any variation in the morphological appearance of the excretory socket cell compared to control animals. excretory socket cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000918 excretory socket cell morphology variant Any variation in the morphological appearance of the excretory socket cell compared to control animals. WB:WBPerson557 Any variation in the progression of the region of a body wall muscle cell that contains the myofilament lattice (adjacent to the hypodermis) over time, from its initial state to the fully differentiated state compared to control. spindle body wall muscle cell development abnormal C_elegans_phenotype_ontology filament lattice body wall muscle cell development abnormal spindle body wall muscle cell development variant WBPhenotype:0000919 body wall muscle cell spindle development variant Any variation in the progression of the region of a body wall muscle cell that contains the myofilament lattice (adjacent to the hypodermis) over time, from its initial state to the fully differentiated state compared to control. WB:WBPaper00000461 WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000920 obsolete body wall muscle cell development variant true OBSOLETE. WB:WBPerson557 Variations in the progression of muscle cells that contain fibers that are divided by transverse bands into striations, over time from an initial condition to a later condition compared to control animals. striated muscle development abnormal C_elegans_phenotype_ontology WBPhenotype:0000921 Possible XP. striated muscle development variant Variations in the progression of muscle cells that contain fibers that are divided by transverse bands into striations, over time from an initial condition to a later condition compared to control animals. GO:0055002 WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of somatic (striated) muscles that run longitudinally in males over time from its initial formation to its mature form compared to control. In C. elegans males have 3 additional sets of sex-specific longitudinal muscles (anterior and posterior outer, anterior and posterior inner, and caudal) that contribute to the body wall musculature (Wormatlas). male longitudinal muscle development abnormal C_elegans_phenotype_ontology WBPhenotype:0000922 male longitudinal muscle development variant Any variation in the progression of somatic (striated) muscles that run longitudinally in males over time from its initial formation to its mature form compared to control. In C. elegans males have 3 additional sets of sex-specific longitudinal muscles (anterior and posterior outer, anterior and posterior inner, and caudal) that contribute to the body wall musculature (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the morphological appearance of the nonstriated muscle compared to control animals. nonstriated muscle morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000923 nonstriated muscle morphology variant Any variation in the morphological appearance of the nonstriated muscle compared to control animals. WB:WBPerson557 Any variation in the morphological appearance of the striated muscle compared to control animals. striated muscle morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000924 striated muscle morphology variant Any variation in the morphological appearance of the striated muscle compared to control animals. WB:WBPerson557 Any variation in the morphological appearance of the sex muscles compared to control animals. sex muscle morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000925 sex muscle morphology variant Any variation in the morphological appearance of the sex muscles compared to control animals. WB:WBPerson557 Any variation in the morphological appearance of the body wall muscle compared to control animals. body wall muscle morphology abnormal C_elegans_phenotype_ontology Dim WBPhenotype:0000926 body wall muscle morphology variant Any variation in the morphological appearance of the body wall muscle compared to control animals. WB:WBPerson557 Any variation in the morphological appearance of the male longitudinal muscle compared to control animals. male longitudinal muscle morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000927 male longitudinal muscle morphology variant Any variation in the morphological appearance of the male longitudinal muscle compared to control animals. WB:WBPerson557 Animals exhibit variations in any physical or chemical process required to carry out male-specific activities or to be able to perceive and respond to male-specific stimuli compared to control. male physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000928 male physiology variant Animals exhibit variations in any physical or chemical process required to carry out male-specific activities or to be able to perceive and respond to male-specific stimuli compared to control. WB:WBPerson557 Animals exhibit variations in any physical or chemical process required to carry out hermaphrodite-specific activities or to be able to perceive and respond to hermaphrodite-specific stimuli compared to control. hermaphrodite physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000929 hermaphrodite physiology variant Animals exhibit variations in any physical or chemical process required to carry out hermaphrodite-specific activities or to be able to perceive and respond to hermaphrodite-specific stimuli compared to control. WB:WBPerson557 Variations in the progression of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as one sex or the other in the population, over time from an initial condition to a later condition compared to control animals. sexually dimorphic development abnormal C_elegans_phenotype_ontology WBPhenotype:0000930 sexually dimorphic development variant Variations in the progression of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as one sex or the other in the population, over time from an initial condition to a later condition compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in their response to bisphenol A compared to that observed in control animals. bisphenol A response abnormal C_elegans_phenotype_ontology WBPhenotype:0000931 bisphenol A response variant Animals exhibit variations in their response to bisphenol A compared to that observed in control animals. WB:WBPerson557 Animals respond to bisphenol A at a lower concentration or a shorter exposure time compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000932 bisphenol A hypersensitive Animals respond to bisphenol A at a lower concentration or a shorter exposure time compared to control animals. WB:WBPerson557 The descendants of the MS blastomere exhibit any variation in developmental programs compared to their counterparts in control animals. MS lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000933 MS lineage variant The descendants of the MS blastomere exhibit any variation in developmental programs compared to their counterparts in control animals. WB:WBPaper00002330 WB:WBPerson2021 Animals exhibit variations in the form, structure or composition of any of its parts during a given developmental stage compared to control animals. developmental morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000934 developmental morphology variant Animals exhibit variations in the form, structure or composition of any of its parts during a given developmental stage compared to control animals. WB:WBPerson2021 WB:WBPerson557 The descendants of the D blastomere exhibit any variation in developmental programs compared to their counterparts in control animals. D lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000935 D lineage variant The descendants of the D blastomere exhibit any variation in developmental programs compared to their counterparts in control animals. WB:WBPaper00002572 WB:WBPerson2021 The descendants of the P4 blastomere exhibit any variation in developmental programs compared to their counterparts in control animals. P4 lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000936 P4 lineage variant The descendants of the P4 blastomere exhibit any variation in developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of the W precursor cell exhibit any variation in developmental programs compared to their counterparts in control animals. W lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000937 W lineage variant The descendants of the W precursor cell exhibit any variation in developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of any of the V precursor cells (V1-V6) in male animals, exhibit any variation in developmental programs compared to their counterparts in control animals. male V lineages abnormal C_elegans_phenotype_ontology WBPhenotype:0000938 male V lineages variant The descendants of any of the V precursor cells (V1-V6) in male animals, exhibit any variation in developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of TL or TR cells in male animals exhibit any variation in developmental programs compared to their counterparts in control animals. male T lineages abnormal C_elegans_phenotype_ontology WBPhenotype:0000939 male T lineages variant The descendants of TL or TR cells in male animals exhibit any variation in developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of any of the P precursor cells (P1-P12) in male animals exhibit any variation in developmental programs compared to their counterparts in control animals. male P lineages abnormal C_elegans_phenotype_ontology WBPhenotype:0000940 male P lineages variant The descendants of any of the P precursor cells (P1-P12) in male animals exhibit any variation in developmental programs compared to their counterparts in control animals. WB:WBPerson2021 The descendants of the M precursor cell in male animals, exhibit any variation in developmental programs compared to their counterparts in control animals. male M lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000941 male M lineage variant The descendants of the M precursor cell in male animals, exhibit any variation in developmental programs compared to their counterparts in control animals. WB:WBPerson2021 Any variation in the progression of an accessory cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. An accessory cell supports sensory neurons. accessory cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000942 accessory cell development variant Any variation in the progression of an accessory cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. An accessory cell supports sensory neurons. WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of a cluster of neuron cell bodies (somata) over time from its initial formation to its mature form compared to control. ganglion development abnormal C_elegans_phenotype_ontology WBPhenotype:0000943 ganglion development variant Any variation in the progression of a cluster of neuron cell bodies (somata) over time from its initial formation to its mature form compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of a neuronal extension (such as axons or dendrites) over time, from its formation to the mature structure compared to control. neurite development abnormal C_elegans_phenotype_ontology WBPhenotype:0000944 neurite development variant Variations in the progression of a neuronal extension (such as axons or dendrites) over time, from its formation to the mature structure compared to control. GO:0031175 WB:WBPerson2021 Any variation in the progression of a dense feltwork of interwoven cytoplasmic processes of nerve cells (dendrites and axons) and support cells, over time from an initial condition to a later condition, compared to control. neuropil development abnormal C_elegans_phenotype_ontology WBPhenotype:0000945 neuropil development variant Any variation in the progression of a dense feltwork of interwoven cytoplasmic processes of nerve cells (dendrites and axons) and support cells, over time from an initial condition to a later condition, compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of a set of interacting or interdependent entities forming the pharyngeal nervous system over time from an initial condition to a later condition compared to control animals. The nervous system is involved in the coordination and control of bodily activities and the interpretation of information from the senses. pharyngeal nervous system development abnormal C_elegans_phenotype_ontology WBPhenotype:0000946 pharyngeal nervous system development variant Variations in the progression of a set of interacting or interdependent entities forming the pharyngeal nervous system over time from an initial condition to a later condition compared to control animals. The nervous system is involved in the coordination and control of bodily activities and the interpretation of information from the senses. GO:0007420 WB:WBPerson2021 WB:WBPerson557 Variations in the form, structure or composition of the material made up of fibers forming a framework and support structure for body tissues and organs compared to control. connective tissue morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000947 connective tissue morphology variant Variations in the form, structure or composition of the material made up of fibers forming a framework and support structure for body tissues and organs compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the appearance or structure of the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells compared to control (Wormatlas). cuticle morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000948 cuticle morphology variant Any variation in the appearance or structure of the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the appearance of the body cavity compared to control. In C. elegans , an aberrancy in the psedocoelom can involve an accumulation of fluids or fluorescent reporters. pseudocoelom morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000949 pseudocoelom morphology variant Any variation in the appearance of the body cavity compared to control. In C. elegans , an aberrancy in the psedocoelom can involve an accumulation of fluids or fluorescent reporters. WB:WBPerson712 Any variation in the progression of a neuronal sheath cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. A neuronal sheath cell is a structural cell that forms a specialized environment surrounding the sensory endings of a neuron. neuronal sheath cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000950 neuronal sheath cell development variant Any variation in the progression of a neuronal sheath cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. A neuronal sheath cell is a structural cell that forms a specialized environment surrounding the sensory endings of a neuron. WB:WBPerson2021 Any variation in the progression of a socket cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. socket cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0000951 socket cell development variant Any variation in the progression of a socket cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. WB:WBPerson2021 Any variation in the progression of a cluster of neuron somata located close to the nerve ring over time from its initial formation to its mature form compared to control (Wormatlas). anterior ganglion development abnormal C_elegans_phenotype_ontology WBPhenotype:0000952 anterior ganglion development variant Any variation in the progression of a cluster of neuron somata located close to the nerve ring over time from its initial formation to its mature form compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the ganglion that lies dorsally beside the nerve ring in the head over time from its initial formation to its mature form compared to control. In C. elegans, It contains neuron cell bodies that send their neuronal processes into the ring and longitudinal nerves, but form no local neuropil separate from the nerve ring. The dorsal ganglion is in close contact with the dorsal hypodermal cord (Wormatlas). dorsal ganglion development abnormal C_elegans_phenotype_ontology WBPhenotype:0000953 dorsal ganglion development variant Any variation in the progression of the ganglion that lies dorsally beside the nerve ring in the head over time from its initial formation to its mature form compared to control. In C. elegans, It contains neuron cell bodies that send their neuronal processes into the ring and longitudinal nerves, but form no local neuropil separate from the nerve ring. The dorsal ganglion is in close contact with the dorsal hypodermal cord (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the ganglion which lies above and behind the rectum in the tail, in close continuity with the anal hypodermal ridge over time from its initial formation to its mature form compared to control (Wormatlas). dorsorectal ganglia development abnormal C_elegans_phenotype_ontology WBPhenotype:0000954 dorsorectal ganglia development variant Any variation in the progression of the ganglion which lies above and behind the rectum in the tail, in close continuity with the anal hypodermal ridge over time from its initial formation to its mature form compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the left and right lateral ganglia which lie beside the nerve ring in the head over time from its initial formation to its mature form compared to control (Wormatlas). lateral ganglia development abnormal C_elegans_phenotype_ontology WBPhenotype:0000955 lateral ganglia development variant Any variation in the progression of the left and right lateral ganglia which lie beside the nerve ring in the head over time from its initial formation to its mature form compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the left and right lumbar ganglia which lie behind the pre-anal ganglion in the tail, in lateral positions over time from its initial formation to its mature form compared to control (Wormatlas). lumbar ganglia development abnormal C_elegans_phenotype_ontology WBPhenotype:0000956 lumbar ganglia development variant Any variation in the progression of the left and right lumbar ganglia which lie behind the pre-anal ganglion in the tail, in lateral positions over time from its initial formation to its mature form compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the neuron somata associated with the post-deirid over time from its initial formation to its mature form compared to control (Wormatlas). posterior lateral ganglion development abnormal C_elegans_phenotype_ontology WBPhenotype:0000957 posterior lateral ganglion development variant Any variation in the progression of the neuron somata associated with the post-deirid over time from its initial formation to its mature form compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the ganglion which lies at the posterior limit of the ventral nerve cord in the tail over time from its initial formation to its mature form compared to control (Wormatlas). preanal ganglion development abnormal C_elegans_phenotype_ontology WBPhenotype:0000958 preanal ganglion development variant Any variation in the progression of the ganglion which lies at the posterior limit of the ventral nerve cord in the tail over time from its initial formation to its mature form compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the ganglion which lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore over time from its initial formation to its mature form compared to control (Wormatlas). retrovesicular ganglion development abnormal C_elegans_phenotype_ontology WBPhenotype:0000959 retrovesicular ganglion development variant Any variation in the progression of the ganglion which lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore over time from its initial formation to its mature form compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the ganglion which lies ventrally beside the nerve ring in the head, just anterior of the retrovesicular ganglion over time from its initial formation to its mature form compared to control (Wormatlas). ventral ganglion development abnormal C_elegans_phenotype_ontology WBPhenotype:0000960 ventral ganglion development variant Any variation in the progression of the ganglion which lies ventrally beside the nerve ring in the head, just anterior of the retrovesicular ganglion over time from its initial formation to its mature form compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the cellular or subcellular pattern of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals. pattern of transgene expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000961 pattern of transgene expression variant Any variation in the cellular or subcellular pattern of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals. WB:WBPerson557 Any variation in the measured expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals. level of transgene expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000962 level of transgene expression variant Any variation in the measured expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals. WB:WBPerson557 Males exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the organism compared to control animals. male pigmentation abnormal C_elegans_phenotype_ontology WBPhenotype:0000963 male pigmentation variant Males exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the organism compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of DMPP that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000964 DMPP resistant Animals fail to respond to the concentration of DMPP that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals exhibit variations in the programmed cell death pathway that is triggered in cells other than germ cells and that is not subject to upstream checkpoint regulation. somatic cell death abnormal C_elegans_phenotype_ontology WBPhenotype:0000965 somatic cell death variant Animals exhibit variations in the programmed cell death pathway that is triggered in cells other than germ cells and that is not subject to upstream checkpoint regulation. WB:WBPaper00032243 WB:WBPerson712 Progressive decrease in brood size culminating, over generations, in the loss of reproductive ability and thus becoming effectively sterile. Mrt C_elegans_phenotype_ontology WBPhenotype:0000966 germline mortal Progressive decrease in brood size culminating, over generations, in the loss of reproductive ability and thus becoming effectively sterile. WB:WBPaper00003886 WB:WBPaper00027026 WB:WBPerson712 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000967 In the WS193 and WS200 versions of WormBase WBPhenotype:0000967 has term name "male tail spike"; In some older records the term ID WBPhenotype:0000967 had the term name "male distal tip cell behavior abnormal", which may reflect an earlier (now deprecated) usage of the term ID. obsolete male tail spike true Any variation in the structure or appearance of the thin cuticle specialization found at the extreme posterior end of the tail compared to control. C_elegans_phenotype_ontology WBPhenotype:0000968 tail spike variant Any variation in the structure or appearance of the thin cuticle specialization found at the extreme posterior end of the tail compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the structure, organization or placement of the cells that support sensory neurons, compared to that observed in control animals. In C. elegans, this category collectively refers to socket cells, sheath cells, and structural cells, or their processes. accessory cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000969 WBbt:0005762. accessory cell morphology variant Animals exhibit variations in the structure, organization or placement of the cells that support sensory neurons, compared to that observed in control animals. In C. elegans, this category collectively refers to socket cells, sheath cells, and structural cells, or their processes. WB:WBPerson557 WB:WBPerson712 Embryos exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals . embryonic pigmentation abnormal C_elegans_phenotype_ontology WBPhenotype:0000970 embryonic pigmentation variant Embryos exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals . WB:WBPerson557 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the anterior body axis compared to control. anterior pigmentation abnormal C_elegans_phenotype_ontology WBPhenotype:0000971 anterior pigmentation variant Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the anterior body axis compared to control. WB:WBPerson557 Animals exhibit variations in the structure or composition of the glia-like support cell of neuronal sensilla that ensheathes the dendrite tips and or processes of neurons, from that observed in control animals. In C. elegans, sheath cells have highly invaginated and vesiculated surfaces, which provide a specialized environment for dendritic structures. WBPhenotype:0001529 sensilium sheath cell morphology variant neuronal sheath cell morphology abnormal sensilium sheath cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000972 neuronal sheath cell morphology variant Animals exhibit variations in the structure or composition of the glia-like support cell of neuronal sensilla that ensheathes the dendrite tips and or processes of neurons, from that observed in control animals. In C. elegans, sheath cells have highly invaginated and vesiculated surfaces, which provide a specialized environment for dendritic structures. WB:WBPaper00000822 WB:WBPaper00000938 WB:WBPerson712 Animals exhibit an increased frequency of exchange of genetic material between non-sister chromatids of a pair of homologues. C_elegans_phenotype_ontology WBPhenotype:0000973 homologous recombination increased Animals exhibit an increased frequency of exchange of genetic material between non-sister chromatids of a pair of homologues. GO:0007131 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required by a subset of interfacial cells to carry out its normal function or be able to perceive and respond to stimuli, compared to control. It can refer to socket cells, sheath cells and structural cells or their processes (Wormatlas). accessory cell physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000974 accessory cell physiology variant Animals exhibit variations in any physical or chemical process required by a subset of interfacial cells to carry out its normal function or be able to perceive and respond to stimuli, compared to control. It can refer to socket cells, sheath cells and structural cells or their processes (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in any physical or chemical process required for a neuronal sheath cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. neuronal sheath cell physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000975 neuronal sheath cell physiology variant Animals exhibit variations in any physical or chemical process required for a neuronal sheath cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson557 Any variation in the developmental process that results in the creation of defined areas or spaces within the ventral cord to which cells respond and eventually are instructed to differentiate compared to control. ventral cord patterning abnormal C_elegans_phenotype_ontology WBPhenotype:0000976 ventral cord patterning variant Any variation in the developmental process that results in the creation of defined areas or spaces within the ventral cord to which cells respond and eventually are instructed to differentiate compared to control. GO:0007389 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of the components of the gonad that are separate from the germline proper compared to control animals. somatic gonad morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000977 somatic gonad morphology variant Animals exhibit variations in the form, structure or composition of the components of the gonad that are separate from the germline proper compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the spermatheca to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. spermatheca physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000978 spermatheca physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the spermatheca to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson712 Animals exhibit defects in any physical or chemical process involved in the dilation of the distal spermatheca which is required for the oocyte exit from the gonad arm. C_elegans_phenotype_ontology WBPhenotype:0000979 spermatheca dilation defective Animals exhibit defects in any physical or chemical process involved in the dilation of the distal spermatheca which is required for the oocyte exit from the gonad arm. WB:WBPaper00003371 WB:WBPerson2021 WB:WBPerson557 Any variation in the muscle contractions that control feeding compared to control. Contractions are necessary for bacterial uptake from the surrounding environment. pharyngeal contraction abnormal C_elegans_phenotype_ontology WBPhenotype:0000980 pharyngeal contraction variant Any variation in the muscle contractions that control feeding compared to control. Contractions are necessary for bacterial uptake from the surrounding environment. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids (non-motile sperm) compared to control. WBPhenotype:0000713 spermatocyte division variant spermatocyte division abnormal spermatocyte meiosis abnormal C_elegans_phenotype_ontology WBPhenotype:0000981 spermatocyte meiosis variant Animals exhibit variations in the meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids (non-motile sperm) compared to control. GO:0048137 WB:WBPaper00027300 WB:WBPerson2021 Animals exhibit variations in the ability of a relatively unspecialized spermatocyte to acquire the properties of a spermatid cell compared to control. spermatid maturation abnormal C_elegans_phenotype_ontology WBPhenotype:0000982 spermatid maturation variant Animals exhibit variations in the ability of a relatively unspecialized spermatocyte to acquire the properties of a spermatid cell compared to control. WB:WBPaper00027300 WB:WBPerson2021 Any perturbation that disrupts the fusion of male and female gametes (sperm and oocyte) during sexual reproduction. C_elegans_phenotype_ontology WBPhenotype:0000983 fertilization defective Any perturbation that disrupts the fusion of male and female gametes (sperm and oocyte) during sexual reproduction. GO:0009566 WB:WBPerson2021 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency of the posterior body axis compared to control. posterior pigmentation abnormal C_elegans_phenotype_ontology WBPhenotype:0000984 posterior pigmentation variant Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency of the posterior body axis compared to control. WB:WBPerson557 Animals exhibit variations in any physical or chemical process required for the blast cell to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals. blast cell physiology variant blast cell physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000985 blast cell physiology phenotype Animals exhibit variations in any physical or chemical process required for the blast cell to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals. GO:0009987 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for the epithelial cell to carry out its normal functions or activities, compared to control animals. epithelial cell physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000986 epithelial cell physiology variant Animals exhibit variations in any physical or chemical process required for the epithelial cell to carry out its normal functions or activities, compared to control animals. GO:0009987 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for the germ cell to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals. germ cell physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000987 germ cell physiology variant Animals exhibit variations in any physical or chemical process required for the germ cell to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals. GO:0009987 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for the gland cell to carry out its normal functions or activities or be able to perceive and respond to signals, compared to control animals. gland cell physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000988 gland cell physiology variant Animals exhibit variations in any physical or chemical process required for the gland cell to carry out its normal functions or activities or be able to perceive and respond to signals, compared to control animals. GO:0009987 WB:WBPerson557 WB:WBPerson712 Animals exhibit deviations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for a marginal cell to carry out its normal function and activities or be able to perceive and respond to stimuli. marginal cell physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000989 marginal cell physiology variant Animals exhibit deviations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for a marginal cell to carry out its normal function and activities or be able to perceive and respond to stimuli. GO:0009987 WB:WBPerson557 Animals exhibit variations in any physical or chemical process required for the muscle cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. muscle cell physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0000990 muscle cell physiology variant Animals exhibit variations in any physical or chemical process required for the muscle cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. GO:0009987 WB:WBPerson557 WB:WBPerson712 OBSOLETE: Activity of the neuron varies from that observed for control animals or neurons. In C. elegans neuron activity is often assayed by observing calcium spikes. C_elegans_phenotype_ontology WBPhenotype:0000991 obsolete neuron physiology variant true OBSOLETE: Activity of the neuron varies from that observed for control animals or neurons. In C. elegans neuron activity is often assayed by observing calcium spikes. WB:WBPaper00032221 WB:WBPerson712 Failure to execute the characteristic response to high concentrations of sodium chloride solution. C. elegans typically avoids high concentrations of sodium chloride solution. C_elegans_phenotype_ontology WBPhenotype:0000992 high sodium chloride concentration osmotic avoidance defective Failure to execute the characteristic response to high concentrations of sodium chloride solution. C. elegans typically avoids high concentrations of sodium chloride solution. WB:WBPerson2021 Animals fail to contract the anal depressor muscle. Exp C_elegans_phenotype_ontology WBPhenotype:0000993 anal depressor contraction defect Animals fail to contract the anal depressor muscle. WB:WBPaper00001256 Any variations in the contraction of the enteric muscles that are involved in defecation motor program compared to control. intestinal contractions abnormal C_elegans_phenotype_ontology Emc enteric muscle contraction variant WBPhenotype:0000994 intestinal contractions variant Any variations in the contraction of the enteric muscles that are involved in defecation motor program compared to control. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000995 WBPhenotype:0000995 an alt_id for "sodium chloride chemotaxis defective" (WBPhenotype:0001084) (WS193 OBO and WS200 site) AND has term name "pos body wall contraction defect" (dump_phenotype_ace.pl) true Animals exhibit defects in the expulsion of gut contents. In C. elegans, this refers to the final step of the defecation cycle in which the intestinal muscle and anal depressor contractions further pressurize intestinal contents and open the anus to permit expulsion. Emc Exp C_elegans_phenotype_ontology WBPhenotype:0000996 expulsion defective Animals exhibit defects in the expulsion of gut contents. In C. elegans, this refers to the final step of the defecation cycle in which the intestinal muscle and anal depressor contractions further pressurize intestinal contents and open the anus to permit expulsion. WB:WBPaper00001256 WB:WBPaper00031246 WB:WBPerson712 Animals tend to track and stay within low temperature environments. C_elegans_phenotype_ontology WBPhenotype:0000997 cryophilic Animals tend to track and stay within low temperature environments. WB:WBPerson2021 WB:WBPerson557 Animals tend to track and stay within high temperature environments. C_elegans_phenotype_ontology WBPhenotype:0000998 thermophilic Animals tend to track and stay within high temperature environments. WB:WBPerson2021 WB:WBPerson557 The responses of an animal towards temperature are not influenced by its cultivation temperature. C_elegans_phenotype_ontology WBPhenotype:0000999 athermotactic The responses of an animal towards temperature are not influenced by its cultivation temperature. WB:WBPerson363 Any variation in the behavior characteristic during certain developmental stage(s) compared to control. developmental behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0001000 developmental behavior variant Any variation in the behavior characteristic during certain developmental stage(s) compared to control. WB:cab Variations in the specific actions or reactions of dauer stage animals in response to external or internal stimuli compared to that observed in control animals. dauer behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0001001 dauer behavior variant Variations in the specific actions or reactions of dauer stage animals in response to external or internal stimuli compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the specific actions or reactions of the head muscles in response to external or internal stimuli compared to that observed in control animals. head muscle behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0001002 head muscle behavior variant Variations in the specific actions or reactions of the head muscles in response to external or internal stimuli compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Animals die at the L4 stage of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0001003 L4 lethal Animals die at the L4 stage of the life cycle. WB:WBPerson2021 Any variation in the relaxation of pharyngeal muscles after contraction events compared to control. pharyngeal relaxation abnormal C_elegans_phenotype_ontology WBPhenotype:0001004 pharyngeal relaxation variant Any variation in the relaxation of pharyngeal muscles after contraction events compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the spontaneous or induced backward crawling locomotion of an animal compared to control. backward locomotion abnormal C_elegans_phenotype_ontology WBPhenotype:0001005 backward locomotion variant Variations in the spontaneous or induced backward crawling locomotion of an animal compared to control. WB:WBPerson2021 WB:WBPerson557 The number of coordinated contraction-relaxation cycles (pumps) exhibited by the pharyngeal muscle deviates from that observed for control animals. pharyngeal pumping rate abnormal C_elegans_phenotype_ontology feeding rate dynamics abnormal pumping rate dynamics abnormal WBPhenotype:0001006 pharyngeal pumping rate variant The number of coordinated contraction-relaxation cycles (pumps) exhibited by the pharyngeal muscle deviates from that observed for control animals. WB:WBPaper00001709 WB:WBPerson712 Unclassified abnormality in the inviable one- to four-cell embryo. Emb Oth other abnormal C_elegans_phenotype_ontology WBPhenotype:0001007 other abnormality early emb Unclassified abnormality in the inviable one- to four-cell embryo. WB:cab Variations in the progression of a set of interacting or interdependent entities forming the male nervous system over time from an initial condition to a later condition compared to control animals. The nervous system is involved in the coordination and control of bodily activities and the interpretation of information from the senses. male nervous system development abnormal C_elegans_phenotype_ontology WBPhenotype:0001008 male nervous system development variant Variations in the progression of a set of interacting or interdependent entities forming the male nervous system over time from an initial condition to a later condition compared to control animals. The nervous system is involved in the coordination and control of bodily activities and the interpretation of information from the senses. GO:0007420 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a particular developmental stage of the amimal compared to control animals. developmental pigmentation abnormal C_elegans_phenotype_ontology WBPhenotype:0001009 developmental pigmentation variant Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a particular developmental stage of the amimal compared to control animals. WB:WBPerson557 Animals appear unusually transparent when compared to control. Clr C_elegans_phenotype_ontology WBPhenotype:0001010 clear Animals appear unusually transparent when compared to control. WB:WBPaper00004402 WB:WBPaper00005654 WB:cab Population of unhatched eggs exhibit a complex combination of defects that do not match other class definitions. Emb C_elegans_phenotype_ontology WBPhenotype:0001011 complex phenotype early emb Population of unhatched eggs exhibit a complex combination of defects that do not match other class definitions. WB:cab WB:cgc7141 Animals exhibit variations in their response to disease causing agents, compared to control. Pathogen response includes prevention, damage control and recovery from the infection caused by the attack. bacterial load variant organism pathogen response abnormal C_elegans_phenotype_ontology WBPhenotype:0001012 organism pathogen response variant Animals exhibit variations in their response to disease causing agents, compared to control. Pathogen response includes prevention, damage control and recovery from the infection caused by the attack. GO:0006952 WB:WBPaper00032196 WB:WBPerson2021 WB:WBPerson712 Animals are more prone to infection compared to control. Esp C_elegans_phenotype_ontology enhanced susceptibility to pathogens WBPhenotype:0001013 pathogen susceptibility increased Animals are more prone to infection compared to control. WB:WBPaper00005370 WB:WBPaper00024299 WB:cab Animals are less prone to infection compared to control. C_elegans_phenotype_ontology pathogen susceptibility decreased WBPhenotype:0001014 pathogen resistance increased Animals are less prone to infection compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during any development stages compared to control animals. developmental growth abnormal C_elegans_phenotype_ontology WBPhenotype:0001015 developmental growth variant Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during any development stages compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the larval stages compared to control animals. larval growth abnormal C_elegans_phenotype_ontology WBPhenotype:0001016 larval growth variant Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the larval stages compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the adult stage compared to control animals. adult growth abnormal C_elegans_phenotype_ontology WBPhenotype:0001017 adult growth variant Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the adult stage compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation that disrupts the cytoplasmic division of a cell during embryonic development compared to control. Cyk C_elegans_phenotype_ontology WBPhenotype:0001018 cytokinesis variant emb Any variation that disrupts the cytoplasmic division of a cell during embryonic development compared to control. GO:0000910 WB:WBPerson2021 Animals arrest during the stage between early and late larval development. In C. elegans, mid larval arrest occurs during the L2 to L3 stages of development. C_elegans_phenotype_ontology WBPhenotype:0001019 mid larval arrest Animals arrest during the stage between early and late larval development. In C. elegans, mid larval arrest occurs during the L2 to L3 stages of development. WB:cab Animals die during the final stages of embryogenesis. In C. elegans, this lethality refers to death during the last (3-fold) stage of embryogenesis, which normally occurs 620-800 min after the first cleavage at 20C, the stage after elongation. Emb Led C_elegans_phenotype_ontology WBPhenotype:0001020 embryonic lethal late emb Animals die during the final stages of embryogenesis. In C. elegans, this lethality refers to death during the last (3-fold) stage of embryogenesis, which normally occurs 620-800 min after the first cleavage at 20C, the stage after elongation. WB:WBPerson101 Genetically male animals exhibit deviations in the sexual program specific to males. In C. elegans, this often refers to XO animals being transformed into fertile hermaphrodites. Her male sexual development abnormal C_elegans_phenotype_ontology WBPhenotype:0001021 male sexual development variant Genetically male animals exhibit deviations in the sexual program specific to males. In C. elegans, this often refers to XO animals being transformed into fertile hermaphrodites. WB:WBPaper00000498 WB:WBPerson2021 Genetically hermaphrodite animals exhibit deviations in the sexual program specific to hermaphrodites. In C. elegans, this refers to XX animals that develop as males or intersexuals instead of self-fertile hermaphrodites. hermaphrodite sexual development abnormal C_elegans_phenotype_ontology WBPhenotype:0001022 hermaphrodite sexual development variant Genetically hermaphrodite animals exhibit deviations in the sexual program specific to hermaphrodites. In C. elegans, this refers to XX animals that develop as males or intersexuals instead of self-fertile hermaphrodites. WB:WBPerson2021 Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as one sex or the other in the population, from that observed for control animals. sexually dimorphic morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001023 sexually dimorphic morphology variant Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as one sex or the other in the population, from that observed for control animals. GO:0009886 WB:WBPerson712 Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as a male in the population, from that observed for control males. male morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001024 male morphology variant Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as a male in the population, from that observed for control males. GO:0009886 WB:WBPerson712 Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as a hermaphrodite in the population, from that observed for control hermaphrodites. hermaphrodite morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001025 hermaphrodite morphology variant Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as a hermaphrodite in the population, from that observed for control hermaphrodites. GO:0009886 WB:WBPerson712 Animals exhibit variations in the form, structure or composition of the membrane enclosed organelle which contains most of the cell's genetic material during the early embryonic stage compared to control animals (Wormatlas). Emb Nmo C_elegans_phenotype_ontology WBPhenotype:0001026 nuclear morphology variation early emb Animals exhibit variations in the form, structure or composition of the membrane enclosed organelle which contains most of the cell's genetic material during the early embryonic stage compared to control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Embryos show defects in the placement of the nucleus to a specific location within the cell. Emb Npo nuclear position abnormal C_elegans_phenotype_ontology WBPhenotype:0001027 nuclear position defective early emb Embryos show defects in the placement of the nucleus to a specific location within the cell. WB:WBPerson2021 WB:WBPerson557 The morphological appearance of nuclei differs from control animals. nuclear appearance abnormal C_elegans_phenotype_ontology nuclear morphology variant WBPhenotype:0001028 nuclear appearance variant The morphological appearance of nuclei differs from control animals. WB:cab Animals exhibit an uneven distribution of biochromes or any other substances that cause disparate transparency/translucency compared to control animals. Pch C_elegans_phenotype_ontology WBPhenotype:0001029 patchy coloration Animals exhibit an uneven distribution of biochromes or any other substances that cause disparate transparency/translucency compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any deficiency in the lipid bilayer, the equivalent of the nuclear envelope, that surrounds each pronucleus within gametes and within the early zygote after pronuclear reformation (Wormatlas). Emb Pna pronuclear envelope abnormal C_elegans_phenotype_ontology WBPhenotype:0001030 pronuclear envelope defective early emb Any deficiency in the lipid bilayer, the equivalent of the nuclear envelope, that surrounds each pronucleus within gametes and within the early zygote after pronuclear reformation (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the movement/fusion of pronuclei in the fertilized oocyte compared to control. For example, lack of male pronuclear migration, female pronuclear migration variable, sometimes multiple female pronuclei, no or small spindle. Emb C_elegans_phenotype_ontology WBPhenotype:0001031 pronuclear migration reduced early emb Any variation in the movement/fusion of pronuclei in the fertilized oocyte compared to control. For example, lack of male pronuclear migration, female pronuclear migration variable, sometimes multiple female pronuclei, no or small spindle. WB:cab WB:cgc7141 Variations in the specific actions or reactions of a larvae in response to external or internal stimuli compared to that observed in control animals. larval behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0001032 larval behavior variant Variations in the specific actions or reactions of a larvae in response to external or internal stimuli compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the spatial pattern of proliferation and differentiation in the germ line compared to control. In C. elegans, this refers to an ectopic mass of proliferating germ cells that occupies the proximal adult germ line, a region normally occupied by gametes. Pro proximal germ cell proliferation abnormal C_elegans_phenotype_ontology WBPhenotype:0001033 proximal germ cell proliferation variant Any variation in the spatial pattern of proliferation and differentiation in the germ line compared to control. In C. elegans, this refers to an ectopic mass of proliferating germ cells that occupies the proximal adult germ line, a region normally occupied by gametes. WB:WBPaper00006484 WB:WBPerson2021 The morphology of pronuclei and nuclei are defective in the early embryo. In C. elegans, this defect is often characterized by pronuclei and nuclei that are small or missing altogether and are often accompanied by spindle defects. Emb pronuclear nuclear appearance abnormal C_elegans_phenotype_ontology WBPhenotype:0001034 pronuclear nuclear appearance defective early emb The morphology of pronuclei and nuclei are defective in the early embryo. In C. elegans, this defect is often characterized by pronuclei and nuclei that are small or missing altogether and are often accompanied by spindle defects. WB:cab WB:cgc7141 The size, number and organization of the components of the nuclei in the early embryo deviate from control . In C. elegans, this is characterized by nuclei that are completely missing or are significantly smaller than normal; often accompanied by spindle and cytokinesis defects. Emb nuclear appearance number abnormal C_elegans_phenotype_ontology nucleus abnormal emb WBPhenotype:0001035 nuclear appearance number defective early emb The size, number and organization of the components of the nuclei in the early embryo deviate from control . In C. elegans, this is characterized by nuclei that are completely missing or are significantly smaller than normal; often accompanied by spindle and cytokinesis defects. WB:cab WB:cgc7141 Any variation that compromises the reproductive ability of an F1 generation animal. C_elegans_phenotype_ontology WBPhenotype:0001036 sterile F1 Any variation that compromises the reproductive ability of an F1 generation animal. WB:WBPerson2021 WB:WBPerson557 Any variation that compromises the reproductive ability of the progeny of an animal. Stp C_elegans_phenotype_ontology WBPhenotype:0001037 sterile progeny Any variation that compromises the reproductive ability of the progeny of an animal. WB:WBPerson2021 WB:WBPerson557 Germ cells do not exit the mitotic cycle, resulting in a expansion of the unspecialized germ cell population compared to control. Tum tumorous germ line C_elegans_phenotype_ontology WBPhenotype:0001038 tumorous germline Germ cells do not exit the mitotic cycle, resulting in a expansion of the unspecialized germ cell population compared to control. WB:WBPaper00002730 WB:WBPerson2021 Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the embryonic stage compared to control animals. embryonic growth abnormal C_elegans_phenotype_ontology WBPhenotype:0001039 embryonic growth variant Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the embryonic stage compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus, compared to control. chemosensory response abnormal C_elegans_phenotype_ontology WBPhenotype:0001040 chemosensory response variant Variations in the state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus, compared to control. GO:0042221 WB:WBPerson2021 WB:cab WB:cgc3824 Animals exhibit defects in the progression of meiosis which ultimately result in embryonic lethality. Emb Mei C_elegans_phenotype_ontology WBPhenotype:0001041 meiosis defective early emb Animals exhibit defects in the progression of meiosis which ultimately result in embryonic lethality. WB:WBPerson2021 WB:WBPerson557 Neurons show impaired ability in the detection, transmission, coordination or their response to information about an animal's internal and external environments. C_elegans_phenotype_ontology WBPhenotype:0001042 neuron function reduced Neurons show impaired ability in the detection, transmission, coordination or their response to information about an animal's internal and external environments. WB:WBPerson2021 WB:WBPerson557 Embryos do not enter or take longer to enter first interphase compared to control. Emb C_elegans_phenotype_ontology WBPhenotype:0001043 interphase entry defective early emb Embryos do not enter or take longer to enter first interphase compared to control. WB:cab WB:cgc7141 Little/no cortical ruffling or pseudocleavage furrow, or excessive cortical activity. In C. elegans, this is often characterized at the two-cell stage. Cpa Emb cortical dynamics abnormal C_elegans_phenotype_ontology WBPhenotype:0001044 cortical dynamics defective early emb Little/no cortical ruffling or pseudocleavage furrow, or excessive cortical activity. In C. elegans, this is often characterized at the two-cell stage. WB:cab WB:cgc7141 Pharyngeal pumping contractions are brief and occur arhythmically in response to stimulus compared to control. C_elegans_phenotype_ontology WBPhenotype:0001045 sporadic pumping Pharyngeal pumping contractions are brief and occur arhythmically in response to stimulus compared to control. WB:WBPaper00001709 Any variations associated with the characteristic morphology of the pharyngeal muscle such as shape, birefringence etc compared to control. pharyngeal muscle morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001046 pharyngeal muscle morphology variant Any variations associated with the characteristic morphology of the pharyngeal muscle such as shape, birefringence etc compared to control. WB:WBPaper00001709 Animals exhibit variations in the movement towards typically attractive water-soluble chemicals compared to control. aqueous positive chemotaxis abnormal C_elegans_phenotype_ontology water soluble chemotaxis abnormal WBPhenotype:0001047 aqueous positive chemotaxis variant Animals exhibit variations in the movement towards typically attractive water-soluble chemicals compared to control. WB:cab WB:cgc3824 Animals exhibit variations in the chemosensory response to volatile organic compounds compared to control. Odr odorant chemosensory response abnormal C_elegans_phenotype_ontology volatile chemosensory response abnormal WBPhenotype:0001048 odorant chemosensory response variant Animals exhibit variations in the chemosensory response to volatile organic compounds compared to control. WB:WBPerson2021 Variations in behavior that is dependent upon the sensation of chemicals, compared to control. chemosensory behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0001049 chemosensory behavior variant Variations in behavior that is dependent upon the sensation of chemicals, compared to control. GO:0007635 WB:WBPerson2021 Animals exhibit variations in any of a series of events in which an organism receives a sensory chemical stimulus, converts it to a molecular signal, and recognizes and characterizes the signal, compared to control. chemosensation abnormal C_elegans_phenotype_ontology WBPhenotype:0001050 chemosensation variant Animals exhibit variations in any of a series of events in which an organism receives a sensory chemical stimulus, converts it to a molecular signal, and recognizes and characterizes the signal, compared to control. GO:0007606 WB:WBPerson2021 Animals exhibit variations in the characteristic movement towards typically attractive cations compared to control. cation positive chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001051 cation positive chemotaxis variant Animals exhibit variations in the characteristic movement towards typically attractive cations compared to control. WB:WBPaper00000387 WB:cab WB:cgc387 Animals exhibit variations in the characteristic movement towards typically attractive anions compared to control. anion positive chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001052 anion positive chemotaxis variant Animals exhibit variations in the characteristic movement towards typically attractive anions compared to control. WB:WBPaper00000387 WB:cab WB:cgc387 Animals exhibit variations in the characteristic movement towards cyclic nucleotides compared to control. cyclic nucleotide positive chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001053 cyclic nucleotide positive chemotaxis variant Animals exhibit variations in the characteristic movement towards cyclic nucleotides compared to control. WB:cab WB:cgc387 Animals fail to exhibit the same taxis behavior as control animals in response to cGMP. In C. elegans, this is characterized by the failure to move towards cGMP. C_elegans_phenotype_ontology WBPhenotype:0001054 cGMP chemotaxis defective Animals fail to exhibit the same taxis behavior as control animals in response to cGMP. In C. elegans, this is characterized by the failure to move towards cGMP. WB:WBPerson2021 WB:cab WB:cgc387 Animals fail to exhibit the same taxis behavior as control animals in response to bromide. In C. elegans, this is characterized by the failure to move towards bromide. C_elegans_phenotype_ontology WBPhenotype:0001055 bromide chemotaxis defective Animals fail to exhibit the same taxis behavior as control animals in response to bromide. In C. elegans, this is characterized by the failure to move towards bromide. WB:cab WB:cgc387 Animals fail to exhibit the same taxis behavior as control animals in response to iodide. In C. elegans, this is characterized by the failure to move towards iodide. C_elegans_phenotype_ontology WBPhenotype:0001056 iodide chemotaxis defective Animals fail to exhibit the same taxis behavior as control animals in response to iodide. In C. elegans, this is characterized by the failure to move towards iodide. WB:cab WB:cgc387 Animals fail to exhibit the same taxis behavior as control animals in response to lithium. In C. elegans, this is characterized by the failure to move towards lithium. C_elegans_phenotype_ontology WBPhenotype:0001057 lithium chemotaxis defective Animals fail to exhibit the same taxis behavior as control animals in response to lithium. In C. elegans, this is characterized by the failure to move towards lithium. WB:cab WB:cgc387 Animals fail to exhibit the same taxis behavior as control animals in response to potassium. In C. elegans, this is characterized by the failure of the animals to move towards potassium. C_elegans_phenotype_ontology WBPhenotype:0001058 potassium chemotaxis defective Animals fail to exhibit the same taxis behavior as control animals in response to potassium. In C. elegans, this is characterized by the failure of the animals to move towards potassium. WB:cab WB:cgc387 Animals fail to exhibit the same taxis behavior as control animals in response to magnesium. In C. elegans, this is characterized by the failure to move towards magnesium. C_elegans_phenotype_ontology WBPhenotype:0001059 magnesium chemotaxis defective Animals fail to exhibit the same taxis behavior as control animals in response to magnesium. In C. elegans, this is characterized by the failure to move towards magnesium. WB:cab WB:cgc387 In C. elegans, this is characterized by the failure to move towards typically attractive volatile organic molecules sensed by the AWC compared to control. C_elegans_phenotype_ontology AWC volatile chemotaxis defective WBPhenotype:0001060 AWC odorant chemotaxis defective In C. elegans, this is characterized by the failure to move towards typically attractive volatile organic molecules sensed by the AWC compared to control. WB:WBPerson2021 In C. elegans, this is characterized by the failure to move towards typically attractive volatile organic molecules sensed by the AWA compared to control. C_elegans_phenotype_ontology AWA volatile chemotaxis defective WBPhenotype:0001061 AWA odorant chemotaxis defective In C. elegans, this is characterized by the failure to move towards typically attractive volatile organic molecules sensed by the AWA compared to control. WB:WBPerson2021 In C. elegans, movement and elongation stop nearly simultaneously soon after the twofold stage of elongation. However, mutant embryos twitch at the one-and-a-half-fold stage of elongation, like control animals, and move as well as control animals at the two- fold stage. C_elegans_phenotype_ontology WBPhenotype:0001062 late paralysis arrested elongation two fold In C. elegans, movement and elongation stop nearly simultaneously soon after the twofold stage of elongation. However, mutant embryos twitch at the one-and-a-half-fold stage of elongation, like control animals, and move as well as control animals at the two- fold stage. WB:cab WB:cgc1894 Fluctuation pattern between inactive, active, and egg-laying states is atypical, based on the analysis of the distribution of the log intervals of egg-laying events compared to control. egg laying phases abnormal C_elegans_phenotype_ontology WBPhenotype:0001063 egg laying phases variant Fluctuation pattern between inactive, active, and egg-laying states is atypical, based on the analysis of the distribution of the log intervals of egg-laying events compared to control. WB:cab pmid:10757762 pmid:9697864 Animals display uncharacteristically long periods during which they do not lay eggs compared to control, usually based on the analysis of the distribution of the log intervals of egg-laying events. In C. elegans, long inactive phases can be observed in HSN-ablated and serotonin-deficient animals. C_elegans_phenotype_ontology WBPhenotype:0001064 inactive phase long Animals display uncharacteristically long periods during which they do not lay eggs compared to control, usually based on the analysis of the distribution of the log intervals of egg-laying events. In C. elegans, long inactive phases can be observed in HSN-ablated and serotonin-deficient animals. WB:cab pmid:10757762 pmid:9697864 Fewer egg-laying events occur within the active phase of egg laying, based on the analysis of the distribution of the log intervals of egg-laying events, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001065 fewer egg laying events during active Fewer egg-laying events occur within the active phase of egg laying, based on the analysis of the distribution of the log intervals of egg-laying events, compared to control. WB:cab pmid:9697864 The period during which the animal is less likely to lay eggs is not typical compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events. inactive phase abnormal C_elegans_phenotype_ontology WBPhenotype:0001066 inactive phase variant The period during which the animal is less likely to lay eggs is not typical compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events. WB:cab pmid:10757762 pmid:9697864 The active phase of egg-laying, the period during which animals are more likely to display multiple egg-laying events, is atypical compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events. active phase abnormal C_elegans_phenotype_ontology WBPhenotype:0001067 active phase variant The active phase of egg-laying, the period during which animals are more likely to display multiple egg-laying events, is atypical compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events. WB:cab pmid:9697864 Animals are not induced to lay eggs in reponse to exogenous serotonin. Serotonin stimulates egg-laying in C. elegans. C_elegans_phenotype_ontology WBPhenotype:0001068 egg laying serotonin resistant Animals are not induced to lay eggs in reponse to exogenous serotonin. Serotonin stimulates egg-laying in C. elegans. WB:WBPaper00000635 WB:WBPaper00031293 WB:WBPerson712 More eggs are laid during the active phase compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events. C_elegans_phenotype_ontology WBPhenotype:0001069 increased egg laying events during active More eggs are laid during the active phase compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events. WB:cab pmid:9697864 The period during which a worm usually does not lay eggs is short compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events. C_elegans_phenotype_ontology WBPhenotype:0001070 inactive phase short The period during which a worm usually does not lay eggs is short compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events. WB:cab pmid:9697864 Activation of the active phase of egg laying is defective, leading to an abnormally long inactive phase, based on the analysis of the distribution of the log intervals of egg-laying events. C_elegans_phenotype_ontology WBPhenotype:0001071 active phase switch defective Activation of the active phase of egg laying is defective, leading to an abnormally long inactive phase, based on the analysis of the distribution of the log intervals of egg-laying events. WB:cab pmid:10757762 pmid:9697864 Any variation in the state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to a food stimulus, compared to control. response to food abnormal C_elegans_phenotype_ontology WBPhenotype:0001072 response to food variant Any variation in the state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to a food stimulus, compared to control. GO:0032094 WB:WBPerson2021 Animals exhibit variations in egg-laying behavior in response to food compared to control. In C. elegans, well-fed animals lay more eggs compared with starved animals. egg laying response to food abnormal C_elegans_phenotype_ontology WBPhenotype:0001073 egg laying response to food variant Animals exhibit variations in egg-laying behavior in response to food compared to control. In C. elegans, well-fed animals lay more eggs compared with starved animals. WB:cab pmid:10757762 The vulval muscle does not respond to serotonin in the same manner as control animals. This phenotype is often assayed by imaging of calcium transients in response to serotonin. C_elegans_phenotype_ontology WBPhenotype:0001074 vulval muscle unresponsive to serotonin The vulval muscle does not respond to serotonin in the same manner as control animals. This phenotype is often assayed by imaging of calcium transients in response to serotonin. WB:cab pmid:14588249 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the vulva muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. vulval muscle physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001075 vulval muscle physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the vulva muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson712 Variations in the chemical reactions and pathways involved in the maintenance of an internal equilibrium within the vulval muscles compared to control. vulval muscle homeostasis metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0001076 vulval muscle homeostasis metabolism variant Variations in the chemical reactions and pathways involved in the maintenance of an internal equilibrium within the vulval muscles compared to control. WB:WBPerson2021 WB:WBPerson557 Karyomeres in AB or P1 often accompanied by weak/thin wobbly spindle. Emb C_elegans_phenotype_ontology WBPhenotype:0001077 chromosome segregation variant karyomeres early emb Karyomeres in AB or P1 often accompanied by weak/thin wobbly spindle. WB:cab WB:cgc7141 Cytokinesis is abnormal in the first or second stages of cell division. Cyk Emb C_elegans_phenotype_ontology WBPhenotype:0001078 cytokinesis defective early emb Cytokinesis is abnormal in the first or second stages of cell division. WB:cab WB:cgc7141 Cytoplasmic movements are atypical. Emb C_elegans_phenotype_ontology WBPhenotype:0001079 cytoplasmic dynamics defective early emb Cytoplasmic movements are atypical. WB:WBPerson1815 WB:cab Excessive shaking and movements are seen in the cell membrane or cytoplasm of one-cell or two-cell embryos. Emb C_elegans_phenotype_ontology WBPhenotype:0001080 excessive blebbing early emb Excessive shaking and movements are seen in the cell membrane or cytoplasm of one-cell or two-cell embryos. WB:cab cgc:5599 Morphology of the cytoplasm differs from control animals. Emb C_elegans_phenotype_ontology WBPhenotype:0001081 cytoplasmic morphology defective early emb Morphology of the cytoplasm differs from control animals. WB:WBPerson1815 WB:cab Abnormally large granules are observed in the cytoplasm of P0. Emb C_elegans_phenotype_ontology WBPhenotype:0001082 large cytoplasmic granules early emb Abnormally large granules are observed in the cytoplasm of P0. WB:cab WB:cgc5599 Multiple vesicles, vacuoles, or cavities are seen during early embryogenesis. Emb C_elegans_phenotype_ontology WBPhenotype:0001083 multiple cytoplasmic cavities early emb Multiple vesicles, vacuoles, or cavities are seen during early embryogenesis. WB:cab cgc:5599 Failure to execute characteristic response to sodium chloride compared to control. In C. elegans, animals move towards attractive concentrations of sodium chloride. NaCl chemotaxis defective C_elegans_phenotype_ontology WBPhenotype:0001084 sodium chloride chemotaxis defective Failure to execute characteristic response to sodium chloride compared to control. In C. elegans, animals move towards attractive concentrations of sodium chloride. WB:WBPaper00000119 Failure to execute characteristic response to butanone compared to control. In C. elegans, animals move towards typically attractive concentrations of butanone. C_elegans_phenotype_ontology WBPhenotype:0001085 butanone chemotaxis defective Failure to execute characteristic response to butanone compared to control. In C. elegans, animals move towards typically attractive concentrations of butanone. WB:WBPaper00001786 Failure to execute characteristic response to trimethylthiazole compared to control. In C. elegans, animals move towards typically attractive concentrations of trimethylthiazole. C_elegans_phenotype_ontology WBPhenotype:0001086 trimethylthiazole chemotaxis defective Failure to execute characteristic response to trimethylthiazole compared to control. In C. elegans, animals move towards typically attractive concentrations of trimethylthiazole. WB:WBPaper00001786 Failure to execute characteristic response to acetone compared to control. In C. elegans, animals move towards typically attractive concentrations of acetone. C_elegans_phenotype_ontology WBPhenotype:0001087 acetone chemotaxis defective Failure to execute characteristic response to acetone compared to control. In C. elegans, animals move towards typically attractive concentrations of acetone. WB:WBPaper00024240 Failure to execute characteristic response to pentanol compared to control. In C. elegans, animals move towards typically attractive concentrations of pentanol. C_elegans_phenotype_ontology WBPhenotype:0001088 pentanol chemotaxis defective Failure to execute characteristic response to pentanol compared to control. In C. elegans, animals move towards typically attractive concentrations of pentanol. WB:WBPerson2021 Failure to execute characteristic response to hexanol compared to control. In C. elegans, animals move towards typically attractive concentrations of hexanol. C_elegans_phenotype_ontology WBPhenotype:0001089 hexanol chemotaxis defective Failure to execute characteristic response to hexanol compared to control. In C. elegans, animals move towards typically attractive concentrations of hexanol. WB:WBPerson2021 Animals are not able to survive at temperatures above standard cultivation temperatures to the same extent as control animals. intrinsic thermotolerance reduced C_elegans_phenotype_ontology WBPhenotype:0001090 thermotolerance reduced Animals are not able to survive at temperatures above standard cultivation temperatures to the same extent as control animals. WB:WBPerson712 Animals exhibit variations in the elimination of fecal matter during the larval stage compared to control animals. larval defecation abnormal C_elegans_phenotype_ontology WBPhenotype:0001091 larval defecation variant Animals exhibit variations in the elimination of fecal matter during the larval stage compared to control animals. WB:WBPerson2021 Animals fail to expel fecal matter during the larval stage. C_elegans_phenotype_ontology WBPhenotype:0001092 larval defecation defect Animals fail to expel fecal matter during the larval stage. WB:WBPerson2021 Animals exhibit variations in any physical or chemical process required for the intestine to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. intestinal physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001093 intestinal physiology variant Animals exhibit variations in any physical or chemical process required for the intestine to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson712 OBSOLETE. Organismal response to NaCl differs from control animals. NaCl response abnormal C_elegans_phenotype_ontology WBPhenotype:0001094 obsolete NaCl response variant true OBSOLETE. Organismal response to NaCl differs from control animals. WB:cab Animals respond to sodium chloride at a lower concentration or a shorter exposure compared to control animals. In C. elegans, this is often assayed through generation time and progeny number. C_elegans_phenotype_ontology WBPhenotype:0001095 organism high sodium chloride hypersensitive Animals respond to sodium chloride at a lower concentration or a shorter exposure compared to control animals. In C. elegans, this is often assayed through generation time and progeny number. WB:cab pmid:16027367 Large protrusion at the normal position of the vulva, as seen in C. elegans lin-12 null animals. ventral protrusion C_elegans_phenotype_ontology WBPhenotype:0001096 protrusion at vulval region Large protrusion at the normal position of the vulva, as seen in C. elegans lin-12 null animals. WB:cab cgc:646 Unspecialized male germ cells (spermatocytes) prematurely acquire the specialized properties of functional sperm. C_elegans_phenotype_ontology WBPhenotype:0001097 premature spermatocyte germ cell differentiation Unspecialized male germ cells (spermatocytes) prematurely acquire the specialized properties of functional sperm. WB:WBPerson2021 WB:cab cgc:4207 Animals lack the passage connecting the posterior intestine to the rectal valve. C_elegans_phenotype_ontology WBPhenotype:0001098 WBbt:0005773. no rectum Animals lack the passage connecting the posterior intestine to the rectal valve. WB:WBPaper00001423 WB:WBPerson2021 The extreme anterior part of the body appears distorted, usually due to uncharacteristic winding. C_elegans_phenotype_ontology WBPhenotype:0001099 nose twisted The extreme anterior part of the body appears distorted, usually due to uncharacteristic winding. WB:WBPerson2021 WB:WBPerson557 Animal dies prior to the gastrulation stage of embryogenesis. Emb C_elegans_phenotype_ontology WBPhenotype:0001100 early embryonic lethal Animal dies prior to the gastrulation stage of embryogenesis. WB:WBPerson2021 Characteristic response to drugs with respect to egg-laying behavior varies compared to control. egg laying response to drug abnormal C_elegans_phenotype_ontology WBPhenotype:0001101 egg laying response to drug variant Characteristic response to drugs with respect to egg-laying behavior varies compared to control. WB:cab Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle during a mitotic cell cycle. Emb C_elegans_phenotype_ontology WBPhenotype:0001102 Possible XP. mitotic spindle defective early emb Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle during a mitotic cell cycle. GO:0007052 WB:WBPerson2021 Early embryos lack the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis. Emb C_elegans_phenotype_ontology WBPhenotype:0001103 spindle absent early emb Early embryos lack the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis. GO:0005819 WB:WBPerson2021 No mitotic spindle is seen in P0. Emb C_elegans_phenotype_ontology WBPhenotype:0001104 P0 spindle absent early emb No mitotic spindle is seen in P0. WB:cab WB:cgc5599 Altered P0 spindle placement causes either a symmetric first division, a division in which P1 is larger than AB, or a division in which the asymmetry is exaggerated such that AB is much larger than normal. Emb P0 spindle position phenotype C_elegans_phenotype_ontology WBPhenotype:0001105 P0 spindle position abnormal Altered P0 spindle placement causes either a symmetric first division, a division in which P1 is larger than AB, or a division in which the asymmetry is exaggerated such that AB is much larger than normal. WB:cab WB:cgc5599 The orientation of the spindle is aberrant in either the AB or the P1 cell. Emb C_elegans_phenotype_ontology WBPhenotype:0001106 spindle orientation variant AB or P1 early emb The orientation of the spindle is aberrant in either the AB or the P1 cell. WB:cab WB:cgc5599 Rotation of the embryonic spindle is aberrant. Emb C_elegans_phenotype_ontology WBPhenotype:0001107 spindle rotation defective early emb Rotation of the embryonic spindle is aberrant. WB:WBPerson1815 WB:cab P0 spindle fails to rotate and extends perpendicular to the long axis of the embryo. Emb C_elegans_phenotype_ontology WBPhenotype:0001108 P0 spindle rotation failure early emb P0 spindle fails to rotate and extends perpendicular to the long axis of the embryo. WB:cab WB:cgc5599 P0 spindle rotates late in the inviable one- to four-cell embryo. Emb C_elegans_phenotype_ontology WBPhenotype:0001109 P0 spindle rotation delayed early emb P0 spindle rotates late in the inviable one- to four-cell embryo. WB:cab WB:cgc5599 Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores. Emb aster abnormal C_elegans_phenotype_ontology WBPhenotype:0001110 aster defective early emb Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores. GO:0005818 WB:WBPerson2021 WB:WBPerson557 Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores in the AB cell. Emb aster AB abnormal C_elegans_phenotype_ontology WBPhenotype:0001111 aster AB defective early emb Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores in the AB cell. WB:WBPerson2021 WB:WBPerson557 The morphology of the AB aster resembles that of the P1 aster in the inviable one- to four-cell embryo. Emb C_elegans_phenotype_ontology WBPhenotype:0001112 aster AB resembles P1 aster early emb The morphology of the AB aster resembles that of the P1 aster in the inviable one- to four-cell embryo. WB:cab WB:cgc5599 Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores in the P1 cell. Emb P1 aster abnormal C_elegans_phenotype_ontology WBPhenotype:0001113 P1 aster defective early emb Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores in the P1 cell. WB:WBPerson2021 WB:WBPerson557 WB:cab WB:cgc5599 The progression of biochemical and morphological processes that occur during successive replication or nuclear replication events is disrupted during the early embryonic stage. Emb C_elegans_phenotype_ontology WBPhenotype:0001114 cell cycle defective early emb The progression of biochemical and morphological processes that occur during successive replication or nuclear replication events is disrupted during the early embryonic stage. WB:WBPerson2021 WB:WBPerson557 Cell cycle timing is abnormal during the first four cell divisions. Emb C_elegans_phenotype_ontology WBPhenotype:0001115 cell cycle timing defective early emb Cell cycle timing is abnormal during the first four cell divisions. WB:WBPerson1815 WB:cab Absolute cell cycle timing during the first four cell divisions is aberrant. Emb absolute cell cycle timing abnormal C_elegans_phenotype_ontology WBPhenotype:0001116 absolute cell cycle timing defective early emb Absolute cell cycle timing during the first four cell divisions is aberrant. WB:WBPerson557 Cell-cell contacts are abnormal in the early embryo. Emb C_elegans_phenotype_ontology WBPhenotype:0001117 cell cell contacts abnormal early emb Cell-cell contacts are abnormal in the early embryo. WB:WBPerson1815 WB:cab Cell position is abnormal in the early embryo. Emb C_elegans_phenotype_ontology WBPhenotype:0001118 cell position defective early emb Cell position is abnormal in the early embryo. WB:WBPerson1815 WB:cab Embryos take longer to divide during the first and second cell divisions. Emb C_elegans_phenotype_ontology WBPhenotype:0001119 cell cycle slow early emb Embryos take longer to divide during the first and second cell divisions. WB:cab WB:cgc5599 Relative cell cycle timing during the first four cell divisions is aberrant. Emb relative cell cycle timing abnormal C_elegans_phenotype_ontology WBPhenotype:0001120 relative cell cycle timing defective early emb Relative cell cycle timing during the first four cell divisions is aberrant. WB:WBPerson1815 WB:cab Asynchrony of the second division is exaggerated and P1 divides more slowly than normal. Emb C_elegans_phenotype_ontology WBPhenotype:0001121 exaggerated asynchrony early emb Asynchrony of the second division is exaggerated and P1 divides more slowly than normal. WB:cab WB:cgc5599 P1 divides before AB. Emb C_elegans_phenotype_ontology WBPhenotype:0001122 reversed asynchrony early emb P1 divides before AB. WB:cab WB:cgc5599 AB and P1 divide synchronously. Emb C_elegans_phenotype_ontology WBPhenotype:0001123 synchronous second division early emb AB and P1 divide synchronously. WB:cab WB:cgc5599 EMS divides at the same time that ABa and ABp divide. Emb C_elegans_phenotype_ontology WBPhenotype:0001124 ABa ABp EMS synchronous division early emb EMS divides at the same time that ABa and ABp divide. WB:cab WB:cgc5599 P2 and EMS divide synchronously. Emb C_elegans_phenotype_ontology WBPhenotype:0001125 P2 EMS synchronous division early emb P2 and EMS divide synchronously. WB:cab WB:cgc5599 Aba, ABp, EMS, or P1 contacts fewer of its sister cells than in control embryos. Emb cell cell contacts abnormal C_elegans_phenotype_ontology WBPhenotype:0001126 cell cell contacts abnormal in four cell embryo Aba, ABp, EMS, or P1 contacts fewer of its sister cells than in control embryos. WB:cab WB:cgc5599 The EMS blastomere fails to extend anteriorly and make extensive contact (hug) with the ABa blastomere. Emb C_elegans_phenotype_ontology WBPhenotype:0001127 EMS anterior extension fails early emb The EMS blastomere fails to extend anteriorly and make extensive contact (hug) with the ABa blastomere. WB:cab WB:cgc5599 EMS extends too far anteriorly at the four cell stage. Emb C_elegans_phenotype_ontology WBPhenotype:0001128 EMS anterior extension extreme early emb EMS extends too far anteriorly at the four cell stage. WB:cab WB:cgc5599 Embryos exhibit defects in the formation, maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis. Emb C_elegans_phenotype_ontology WBPhenotype:0001129 cleavage furrow defective early emb Embryos exhibit defects in the formation, maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis. GO:0032154 WB:WBPerson2021 WB:WBPerson2987 WB:WBPerson557 Cells of the embryo attempt to divide but fail to form two daughter cells. Cyk Emb C_elegans_phenotype_ontology WBPhenotype:0001130 cytokinesis fails early emb Cells of the embryo attempt to divide but fail to form two daughter cells. WB:cab WB:cgc5599 Once formed, the mitotic furrow can "slide"laterally. Emb C_elegans_phenotype_ontology WBPhenotype:0001131 loose mitotic furrow early emb Once formed, the mitotic furrow can "slide"laterally. WB:cab WB:cgc5599 One or more extra cleavage furrows are seen in one or more cells of a one-cell to four-cell embryo Emb C_elegans_phenotype_ontology WBPhenotype:0001132 extra cleavage furrow early emb One or more extra cleavage furrows are seen in one or more cells of a one-cell to four-cell embryo WB:cab WB:cgc5599 The cell division axis is not normal. division axis abnormal C_elegans_phenotype_ontology WBPhenotype:0001133 division axis defective The cell division axis is not normal. WB:WBPerson1815 WB:cab ABa or ABp divide in the wrong orientation. Emb Aba ABp division axis abnormal C_elegans_phenotype_ontology WBPhenotype:0001134 Aba ABp division axis defective early emb ABa or ABp divide in the wrong orientation. WB:cab WB:cgc5599 Animals exhibit defects in the form, structure or composition of any of its parts during the early embryonic stage. Emb C_elegans_phenotype_ontology WBPhenotype:0001135 embryonic morphology defective early emb Animals exhibit defects in the form, structure or composition of any of its parts during the early embryonic stage. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of any of its parts during any developmental stage ranging from zygote formation to hatching compared to control. embryonic morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001136 embryonic morphology variant Animals exhibit variations in the form, structure or composition of any of its parts during any developmental stage ranging from zygote formation to hatching compared to control. WB:WBPerson2021 WB:WBPerson557 Embryos are produced that are less than fifty percent of the size of control embryos. Emb C_elegans_phenotype_ontology WBPhenotype:0001137 embryos small early emb Embryos are produced that are less than fifty percent of the size of control embryos. WB:WBPaper00005599 WB:cab Nucleus is abnormal in the inviable one- to four-cell embryo. Emb nucleus abnormal C_elegans_phenotype_ontology WBPhenotype:0001138 nucleus defective early emb Nucleus is abnormal in the inviable one- to four-cell embryo. WB:WBPerson1815 WB:cab Nuclear envelope does not reassemble properly. Emb C_elegans_phenotype_ontology nuclear reassembly defective early emb WBPhenotype:0001139 nuclear envelope assembly variant early emb Nuclear envelope does not reassemble properly. WB:cab WB:cgc5599 Any variation in the normal orderly movement of neurons from one site to another compared to control. neuron migration abnormal C_elegans_phenotype_ontology WBPhenotype:0001140 neuron migration variant Any variation in the normal orderly movement of neurons from one site to another compared to control. WB:WBPerson2021 After division of either one-cell or two-cell embryos, the nuclei reappear next to the cell division remnant. Emb C_elegans_phenotype_ontology WBPhenotype:0001141 nucleus reforms cell division remnant early emb After division of either one-cell or two-cell embryos, the nuclei reappear next to the cell division remnant. WB:cab WB:cgc5599 Nuclear number is abnormal in the inviable one- to four-cell embryo. Emb C_elegans_phenotype_ontology WBPhenotype:0001142 nuclear number defective early emb Nuclear number is abnormal in the inviable one- to four-cell embryo. WB:WBPerson1815 WB:cab Embryos contain more than one nucleus per cell in the inviable one- to four-cell embryo. Emb Mul C_elegans_phenotype_ontology karyomeres multiple nuclei in early embryo emb WBPhenotype:0001143 multiple nuclei early emb Embryos contain more than one nucleus per cell in the inviable one- to four-cell embryo. WB:cab WB:cgc5599 Defects are either seen in the number or size of the polar bodies in the inviable one- to four-cell embryo. Emb C_elegans_phenotype_ontology WBPhenotype:0001144 polar body number size early emb Defects are either seen in the number or size of the polar bodies in the inviable one- to four-cell embryo. WB:cab WB:cgc5599 Polar body number is abnormal in the inviable one- to four-cell embryo. Emb polar body number abnormal C_elegans_phenotype_ontology WBPhenotype:0001145 polar body number defective early emb Polar body number is abnormal in the inviable one- to four-cell embryo. WB:WBPerson1815 WB:cab Polar body size is abnormal in the inviable one- to four-cell embryo. Emb polar body size abnormal C_elegans_phenotype_ontology WBPhenotype:0001146 polar body size defective early emb Polar body size is abnormal in the inviable one- to four-cell embryo. WB:WBPerson1815 WB:cab Polar bodies are abnormal in the inviable one- to four-cell embryo. Emb polar body abnormal C_elegans_phenotype_ontology WBPhenotype:0001147 polar body defective early emb Polar bodies are abnormal in the inviable one- to four-cell embryo. WB:WBPerson1815 WB:cab Polar body is reabsorbed in the one- to four-cell embryo. Emb C_elegans_phenotype_ontology WBPhenotype:0001148 polar body reabsorbed early emb Polar body is reabsorbed in the one- to four-cell embryo. WB:WBPerson1815 WB:cab OBSOLETE. Emb C_elegans_phenotype_ontology WBPhenotype:0001149 obsolete polar body reabsorbed first early emb true OBSOLETE. WB:WBPerson557 A polar body is reabsorbed in either the one cell- or the two-cell embryo. Emb C_elegans_phenotype_ontology WBPhenotype:0001150 polar body reabsorbed one two early emb A polar body is reabsorbed in either the one cell- or the two-cell embryo. WB:cab WB:cgc5599 Pronucleus is abnormal in the inviable embryo. Emb pronucleus centrosomes abnormal C_elegans_phenotype_ontology WBPhenotype:0001151 pronucleus centrosomes defective early emb Pronucleus is abnormal in the inviable embryo. WB:WBPerson1815 WB:cab Pronucleus migration is abnormal in the inviable embryo. Emb pronuclear migration abnormal C_elegans_phenotype_ontology WBPhenotype:0001152 pronuclear migration defective early emb Pronucleus migration is abnormal in the inviable embryo. WB:WBPerson1815 WB:cab Neither of the pronuclei migrate and they never meet. Emb C_elegans_phenotype_ontology WBPhenotype:0001153 pronuclear migration failure early emb Neither of the pronuclei migrate and they never meet. WB:cab WB:cgc5599 Instead of the maternal pronucleus migrating to the posterior end of the one-cell embryo, the paternal pronucleus migrates to meet the maternal pronucleus in the anterior end. Emb C_elegans_phenotype_ontology WBPhenotype:0001154 paternal pronucleus migrates early emb Instead of the maternal pronucleus migrating to the posterior end of the one-cell embryo, the paternal pronucleus migrates to meet the maternal pronucleus in the anterior end. WB:cab WB:cgc5599 The maternal and paternal pronuclei meet more centrally instead of meeting in the posterior end of the embryo. Emb C_elegans_phenotype_ontology WBPhenotype:0001155 pronuclei meet centrally early emb The maternal and paternal pronuclei meet more centrally instead of meeting in the posterior end of the embryo. WB:cab WB:cgc5599 Maternal or paternal pronucleus is either too small or too large. Emb pronuclear size abnormal C_elegans_phenotype_ontology WBPhenotype:0001156 pronuclear size defective early emb Maternal or paternal pronucleus is either too small or too large. WB:cab WB:cgc5599 Pronuclear breakdown is atypical in the inviable embryo. Emb pronuclear breakdown abnormal C_elegans_phenotype_ontology WBPhenotype:0001157 pronuclear breakdown defective early emb Pronuclear breakdown is atypical in the inviable embryo. WB:WBPerson1815 WB:cab Instead of breaking down synchronously, the two pronuclei break down asynchronously in the inviable one-cell embryo. Emb C_elegans_phenotype_ontology WBPhenotype:0001158 pronuclear breakdown asynchronous early emb Instead of breaking down synchronously, the two pronuclei break down asynchronously in the inviable one-cell embryo. WB:cab WB:cgc5599 Pronucleus morphology is atypical in the inviable embryo. Emb pronuclear morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001159 pronuclear morphology defective early emb Pronucleus morphology is atypical in the inviable embryo. WB:cab WB:cgc5599 Morphology of the pronuclear envelope is atypical in the inviable embryo. Emb pronuclear envelope morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001160 pronuclear envelope morphology defective early emb Morphology of the pronuclear envelope is atypical in the inviable embryo. WB:WBPerson1815 WB:cab Maternal pronucleus has a blurry appearance. The nuclear envelope does not have a crisp circular shape. Emb C_elegans_phenotype_ontology WBPhenotype:0001161 maternal pronucleus indistinct early emb Maternal pronucleus has a blurry appearance. The nuclear envelope does not have a crisp circular shape. WB:cab WB:cgc5599 There are more than two pronuclei in the inviable embryo. Emb pronuclear number abnormal C_elegans_phenotype_ontology WBPhenotype:0001162 pronuclear number defective early emb There are more than two pronuclei in the inviable embryo. WB:WBPerson1815 WB:cab Either the maternal or paternal pronucleus is absent. Emb C_elegans_phenotype_ontology WBPhenotype:0001163 pronucleus formation failure early emb Either the maternal or paternal pronucleus is absent. WB:cab WB:cgc5599 There is either more than one maternal or paternal pronucleus in the inviable embryo. Emb C_elegans_phenotype_ontology WBPhenotype:0001164 excess pronucleus early emb There is either more than one maternal or paternal pronucleus in the inviable embryo. WB:WBPerson1815 WB:cab One-cell embryos have two or more maternal pronuclei. Emb C_elegans_phenotype_ontology WBPhenotype:0001165 excess maternal pronucleus early emb One-cell embryos have two or more maternal pronuclei. WB:cab WB:cgc5599 More than one paternal pronucleus is present in the inviable one-cell embryo or there is a defect in centrosome structure. Emb excess paternal pronucleus abnormal C_elegans_phenotype_ontology WBPhenotype:0001166 excess paternal pronucleus variant centrosome early emb More than one paternal pronucleus is present in the inviable one-cell embryo or there is a defect in centrosome structure. WB:cab WB:cgc5599 Pseudocleavage is atypical in the inviable one-cell embryo. Emb pseudocleavage abnormal C_elegans_phenotype_ontology WBPhenotype:0001167 pseudocleavage defective early emb Pseudocleavage is atypical in the inviable one-cell embryo. WB:WBPerson1815 WB:cab No pseudocleavage is observed before or during pronuclear migration. Emb C_elegans_phenotype_ontology no pseudocleavage WBPhenotype:0001168 pseudocleavage absent early emb No pseudocleavage is observed before or during pronuclear migration. WB:cab WB:cgc5599 Embryos have more pronounced pseudocleavage than normal. Emb C_elegans_phenotype_ontology WBPhenotype:0001169 pseudocleavage exaggerated early emb Embryos have more pronounced pseudocleavage than normal. WB:cab WB:cgc5599 Injected worm stops producing embryos 48 hours after RNAi injection and contains no live/developing embryos at this time. Ste P0 sterile C_elegans_phenotype_ontology WBPhenotype:0001170 sterile F0 48 hours post injection Injected worm stops producing embryos 48 hours after RNAi injection and contains no live/developing embryos at this time. WB:cab WB:cgc5599 The duration of viability in the adult phase of the life-cycle is less than that of control animals. Age C_elegans_phenotype_ontology life span reduced longevity decreased WBPhenotype:0001171 shortened life span The duration of viability in the adult phase of the life-cycle is less than that of control animals. GO:0008340 WB:WBPerson712 Developmentally regulated termination of a cell or cell group does not occur as in control animals. programmed cell death abnormal C_elegans_phenotype_ontology WBPhenotype:0001172 programmed cell death variant Developmentally regulated termination of a cell or cell group does not occur as in control animals. WB:WBPerson712 Animals exhibit variations in the specific activation or halting of processes within a cell that occur through necrosis or programmed cell death pathways different from apoptosis, so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death, compared to control. non apoptotic cell death abnormal C_elegans_phenotype_ontology WBPhenotype:0001173 non apoptotic cell death variant Animals exhibit variations in the specific activation or halting of processes within a cell that occur through necrosis or programmed cell death pathways different from apoptosis, so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death, compared to control. GO:0008219 WB:WBPerson712 Chromosomes fail to segregate away from their homolog, resulting in gametes with no or extra copies of the chromosome. chromosome disjunction abnormal C_elegans_phenotype_ontology WBPhenotype:0001174 chromosome disjunction defective Chromosomes fail to segregate away from their homolog, resulting in gametes with no or extra copies of the chromosome. WB:WBPerson712 Higher numbers of male progeny occur in the population compared to control populations. In C. elegans, the high incidence of males phenotype in a self-fertilizing hermaphrodite population is a result of an increase in X chromosome nondisjunction. Him C_elegans_phenotype_ontology high frequency X chromosome nondisjunction WBPhenotype:0001175 high incidence male progeny Higher numbers of male progeny occur in the population compared to control populations. In C. elegans, the high incidence of males phenotype in a self-fertilizing hermaphrodite population is a result of an increase in X chromosome nondisjunction. WB:WBPaper00004402 WB:WBPaper00005654 WB:WBPerson712 WB:cab One-cell embryos have an altered shape. Emb one cell shape abnormal C_elegans_phenotype_ontology WBPhenotype:0001176 one cell shape defective early emb One-cell embryos have an altered shape. WB:cab WB:cgc5599 Embryos rupture when placed on a 2% agar pad and covered with a coverslip. Emb C_elegans_phenotype_ontology WBPhenotype:0001177 embryo osmotic pressure sensitive early emb Embryos rupture when placed on a 2% agar pad and covered with a coverslip. WB:cab WB:cgc5599 The structure of the egg is impaired, flawed or no longer intact. Emb C_elegans_phenotype_ontology WBPhenotype:0001178 egg integrity defective early emb The structure of the egg is impaired, flawed or no longer intact. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. Phenotypic examination of worms did not reveal an obvious abnormality compared with control animals. No abnormal C_elegans_phenotype_ontology WT WBPhenotype:0001179 The phenotype ontology was restructured such that "Abnormal" is now the root term. The term "Abnormal" with a "Not" qualifier is a suggested replacement for this term. This phenotype was intended to reflect a lack of any phenotypic abnormality in the individuals in question. The C. elegans phenotype ontology no longer has terms specifically used to assert negation of a phenotype. obsolete No variantity scored true OBSOLETE. Phenotypic examination of worms did not reveal an obvious abnormality compared with control animals. WB:cab Animals exhibit an increase in the quantity of germ line cells that have undergone programmed cell death but have not been engulfed. C_elegans_phenotype_ontology WBPhenotype:0001180 accumulated germline cell corpses Animals exhibit an increase in the quantity of germ line cells that have undergone programmed cell death but have not been engulfed. WB:WBPerson712 Animals exhibit an increase in the quantity of non-germ line cells that have undergone programmed cell death but have not been engulfed. C_elegans_phenotype_ontology WBPhenotype:0001181 accumulated somatic cell corpses Animals exhibit an increase in the quantity of non-germ line cells that have undergone programmed cell death but have not been engulfed. WB:WBPerson712 Animals exhibit variations in the amount of fat or lipids present in the organism compared to control animals. fat content abnormal C_elegans_phenotype_ontology lipid content abnormal lipid content variant WBPhenotype:0001182 fat content variant Animals exhibit variations in the amount of fat or lipids present in the organism compared to control animals. GO:0019915 WB:WBPaper00032082 WB:WBPerson712 Animals exhibit less fat or lipid than observed in control animals. C_elegans_phenotype_ontology lipid content reduced WBPhenotype:0001183 fat content reduced Animals exhibit less fat or lipid than observed in control animals. GO:0019915 WB:WBPaper00032082 WB:WBPerson712 Animals exhibit a greater amount of fat or lipids than observed in control animals. C_elegans_phenotype_ontology lipid content increased WBPhenotype:0001184 fat content increased Animals exhibit a greater amount of fat or lipids than observed in control animals. GO:0019915 WB:WBPaper00032082 WB:WBPerson712 The developmental progression of an early embryo over time, from its formation to its mature structure is delayed compared to control. Emb C_elegans_phenotype_ontology WBPhenotype:0001185 embryonic developmental delay early emb The developmental progression of an early embryo over time, from its formation to its mature structure is delayed compared to control. WB:WBPerson2021 WB:WBPerson557 Embryos are either delayed or arrested at pronuclear contact. Emb C_elegans_phenotype_ontology WBPhenotype:0001186 embryo delayed at pronuclear contact early emb Embryos are either delayed or arrested at pronuclear contact. WB:cab WB:cgc5599 EMS divides before P2. Emb C_elegans_phenotype_ontology WBPhenotype:0001187 division EMS before P2 early emb EMS divides before P2. WB:WBPerson557 Animals exhibit variations in the form, structure or composition of radial arrangement of actin within the pharyngeal muscle compared to control animals. radial filament structure abnormal C_elegans_phenotype_ontology WBPhenotype:0001188 radial filament structure variant pharynx Animals exhibit variations in the form, structure or composition of radial arrangement of actin within the pharyngeal muscle compared to control animals. WB:WBPaper00026850 WB:WBPerson2021 WB:WBPerson557 Any variation in the cell junctions of the pharyngeal muscle at which the cytoplasmic face of the plasma membrane is attached to actin filaments compared to control. adherens junctions abnormal C_elegans_phenotype_ontology WBPhenotype:0001189 adherens junctions variant pharyngeal muscle Any variation in the cell junctions of the pharyngeal muscle at which the cytoplasmic face of the plasma membrane is attached to actin filaments compared to control. WB:WBPaper00026850 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in any physical or chemical process required for the pharynx to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. pharyngeal physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001190 pharyngeal physiology variant Animals exhibit variations in any physical or chemical process required for the pharynx to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for muscles in the pharynx to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. pharyngeal muscle physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001191 pharyngeal muscle physiology variant Animals exhibit variations in any physical or chemical process required for muscles in the pharynx to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson712 Any variation in the series of molecular signals in which a pharyngeal cell uses calcium ions to convert an extracellular signal into a response, compared to control. calcium signaling pharynx abnormal C_elegans_phenotype_ontology WBPhenotype:0001192 calcium signaling in pharynx variant Any variation in the series of molecular signals in which a pharyngeal cell uses calcium ions to convert an extracellular signal into a response, compared to control. WB:WBPerson2021 WB:WBPerson557 Electropharyngeograms do not show a similar pattern as control animals. C. elegans animals show a repeating regular pattern in which each pump is associated with an excitatory depolarizing wave, often punctuated by brief negative spikes, followed by a plateau phase, and ending with an inhibitory hyperpolarizing wave. C_elegans_phenotype_ontology WBPhenotype:0001193 disorganized pharyngeal EPG Electropharyngeograms do not show a similar pattern as control animals. C. elegans animals show a repeating regular pattern in which each pump is associated with an excitatory depolarizing wave, often punctuated by brief negative spikes, followed by a plateau phase, and ending with an inhibitory hyperpolarizing wave. WB:cab WB:cgc7545 Animals have one or more extra neurons, which are present in places they are normally not found, when compared to the number and location of these neurons in control animals. C_elegans_phenotype_ontology WBPhenotype:0001194 extra and ectopic neuron Animals have one or more extra neurons, which are present in places they are normally not found, when compared to the number and location of these neurons in control animals. WB:WBPaper00027335 WB:WBPerson712 Rhythmic calcium increases in the pharynx are observed less often than in control animals. In C. elegans, rhythmic increases in intracellular calcium are often observed using a transgenically expressed cameleon, a ratiometric calcium indicator. C_elegans_phenotype_ontology WBPhenotype:0001195 generation calcium signal defective pharynx Rhythmic calcium increases in the pharynx are observed less often than in control animals. In C. elegans, rhythmic increases in intracellular calcium are often observed using a transgenically expressed cameleon, a ratiometric calcium indicator. WB:cab WB:cgc4194 WB:cgc7545 Calcium spikes lack synchrony in the musculature of the corpus and the terminal bulb as seen in control. C_elegans_phenotype_ontology WBPhenotype:0001196 synchronization calcium signal defective pharynx Calcium spikes lack synchrony in the musculature of the corpus and the terminal bulb as seen in control. WB:cab WB:cgc7545 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the somatic gonad to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. somatic gonad physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001197 somatic gonad physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the somatic gonad to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the somatic sheath system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. somatic sheath physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001198 somatic sheath physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the somatic sheath system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for the contraction of a thin continuous tube surrounding the proximal portions of the ovary and covering the maturing oocytes to the near portion of the distal gonad arm, compared to control (Wormatlas). gonad sheath contractions abnormal C_elegans_phenotype_ontology WBPhenotype:0001199 gonad sheath contractions variant Animals exhibit variations in any physical or chemical process required for the contraction of a thin continuous tube surrounding the proximal portions of the ovary and covering the maturing oocytes to the near portion of the distal gonad arm, compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Basal contraction rate and or peak contraction rate of the gonadal sheath is reduced relative to control animals. C_elegans_phenotype_ontology WBPhenotype:0001200 gonad sheath contraction rate reduced Basal contraction rate and or peak contraction rate of the gonadal sheath is reduced relative to control animals. WB:cab WB:cgc7545 Animals lack the stereotyped muscle contractions that result in the opening of anus. C_elegans_phenotype_ontology WBPhenotype:0001201 no expulsion defecation Animals lack the stereotyped muscle contractions that result in the opening of anus. WB:WBPerson2021 WB:WBPerson557 Animals respond to nicotine at lower concentrations or shorter exposure compared to control. Nicotine is a cholinergic agonist. C_elegans_phenotype_ontology WBPhenotype:0001202 nicotine hypersensitive Animals respond to nicotine at lower concentrations or shorter exposure compared to control. Nicotine is a cholinergic agonist. WB:WBPerson557 WB:cab WB:cgc7388 Animals fail to respond to the concentration of nicotine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001203 nicotine resistant Animals fail to respond to the concentration of nicotine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 WB:cab WB:cgc7388 Animals fail to respond to the concentration of muscimol that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001204 muscimol resistant Animals fail to respond to the concentration of muscimol that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals respond to muscimol at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001205 muscimol hypersensitive Animals respond to muscimol at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Variations in the process by which an organism travels from one location to another compared to control. movement abnormal C_elegans_phenotype_ontology WBPhenotype:0001206 movement variant Variations in the process by which an organism travels from one location to another compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in a series of protein mediated signals that help relay information within the cell, and thereby affecting changes in the functioning of the cell, compared to control. protein signaling abnormal C_elegans_phenotype_ontology WBPhenotype:0001207 protein signaling variant Any variation in a series of protein mediated signals that help relay information within the cell, and thereby affecting changes in the functioning of the cell, compared to control. WB:WBPerson2021 WB:WBPerson557 Animals show reduced susceptibility to gene silencing triggered by double stranded RNA (RNAi), compared to control. Rde RNAi deficient C_elegans_phenotype_ontology WBPhenotype:0001208 RNAi resistant Animals show reduced susceptibility to gene silencing triggered by double stranded RNA (RNAi), compared to control. WB:WBPerson2021 Apparently normal sinusoidal movement, but appear to have poor traction on the agar surface of a culture plate. Skd C_elegans_phenotype_ontology WBPhenotype:0001209 skiddy Apparently normal sinusoidal movement, but appear to have poor traction on the agar surface of a culture plate. WB:WBPaper00026735 WB:cab Animals exhibit variations in any physical or chemical process taking place in extracellular spaces within or associated with the organism, from that observed for control animals. pericellular component physiology abnormal pericellular component physiology variant C_elegans_phenotype_ontology WBPhenotype:0001210 pericellular component physiology phenotype Animals exhibit variations in any physical or chemical process taking place in extracellular spaces within or associated with the organism, from that observed for control animals. WB:WBPerson712 The physical strength or function of the cuticle varies from that observed for control animals. cuticle integrity abnormal C_elegans_phenotype_ontology WBPhenotype:0001211 cuticle integrity variant The physical strength or function of the cuticle varies from that observed for control animals. WB:WBPerson712 The strength of the cuticle is less robust than that observed for control animals. In C. elegans the strength of the cuticle is often assayed by it's ability to protect the animal from exposure to bleach or other compounds. C_elegans_phenotype_ontology WBPhenotype:0001212 cuticle fragile The strength of the cuticle is less robust than that observed for control animals. In C. elegans the strength of the cuticle is often assayed by it's ability to protect the animal from exposure to bleach or other compounds. WB:WBPerson712 Animals exhibit a decrease in any parameter used to measure locomotion compared to control animals. WBPhenotype:0001288 movement reduced C_elegans_phenotype_ontology WBPhenotype:0001213 locomotion reduced Animals exhibit a decrease in any parameter used to measure locomotion compared to control animals. WB:cab OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0001214 obsolete metaphase to anaphase transition fails true OBSOLETE. WB:WBPerson557 Variations in the mitotic expansion of germ cell populations or in the appearance of nuclei during development in the premeiotic region of the germline compared to control. germ cell mitosis abnormal C_elegans_phenotype_ontology WBPhenotype:0001215 germ cell mitosis variant Variations in the mitotic expansion of germ cell populations or in the appearance of nuclei during development in the premeiotic region of the germline compared to control. WB:WBPaper00001007 WB:WBPaper00005486 WB:WBPerson2021 Oocyte chromosomes arrest in metaphase of meiosis I without transitioning to anaphase or producing polar bodies. Mat C_elegans_phenotype_ontology WBPhenotype:0001216 meiosis metaphase to anaphase transition block Oocyte chromosomes arrest in metaphase of meiosis I without transitioning to anaphase or producing polar bodies. WB:cab pmid:11134076 Germ line cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase during mitosis, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001217 germ cell mitosis metaphase to anaphase transition block Germ line cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase during mitosis, compared to control. WB:WBPerson712 Animals exhibit variations in the rate or extent of programmed cell death as it pertains to a sex-specific feature, compared to control populations. cell death sexually dimorphic abnormal C_elegans_phenotype_ontology WBPhenotype:0001218 cell death sexually dimorphic variant Animals exhibit variations in the rate or extent of programmed cell death as it pertains to a sex-specific feature, compared to control populations. WB:WBPerson712 Animals exhibit a decrease in the rate or extent of programmed cell death and thus an increase in cell survival, as it pertains to a sex-specific feature, compared to control populations. C_elegans_phenotype_ontology WBPhenotype:0001219 cell survival sexually dimorphic increased Animals exhibit a decrease in the rate or extent of programmed cell death and thus an increase in cell survival, as it pertains to a sex-specific feature, compared to control populations. WB:WBPerson712 Animals exhibit in increase in the rate or extent of programmed cell death as it pertains to a sex-specific feature, compared to control populations. C_elegans_phenotype_ontology WBPhenotype:0001220 cell death sexually dimorphic increased Animals exhibit in increase in the rate or extent of programmed cell death as it pertains to a sex-specific feature, compared to control populations. WB:WBPerson712 Animal fails to exhibit characteristic response after a nose-on collision with an object compared to control. In C. elegans, this is usually assayed with a hair or similar fiber. The nose is the anterior most tip of the animal. Not C_elegans_phenotype_ontology WBPhenotype:0001221 nose touch defective Animal fails to exhibit characteristic response after a nose-on collision with an object compared to control. In C. elegans, this is usually assayed with a hair or similar fiber. The nose is the anterior most tip of the animal. WB:WBPaper00001705 WB:WBPerson557 Animals exhibit an increase in frequency of transposition events (DNA movement to different positions within the genome of a single cell) causing an accumulation of lesions within the genome, compared to control. C_elegans_phenotype_ontology Mut mutator WBPhenotype:0001222 transposon mutator Animals exhibit an increase in frequency of transposition events (DNA movement to different positions within the genome of a single cell) causing an accumulation of lesions within the genome, compared to control. WB:WBPerson2021 WB:WBPerson557 Animals show reduced susceptibility to gene silencing in the germline triggered by double stranded RNA (RNAi), compared to control. C_elegans_phenotype_ontology WBPhenotype:0001223 germline RNAi resistant Animals show reduced susceptibility to gene silencing in the germline triggered by double stranded RNA (RNAi), compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the processes that govern the extension of axons compared to control. axon outgrowth abnormal C_elegans_phenotype_ontology axon migration variant WBPhenotype:0001224 axon outgrowth variant Any variation in the processes that govern the extension of axons compared to control. GO:0048675 WB:WBPerson2021 Animals are missing the interfacial hypodermal cell (socket cell) of the phasmid sensillum pore. C_elegans_phenotype_ontology Psa WBPhenotype:0001225 phasmid socket absent Animals are missing the interfacial hypodermal cell (socket cell) of the phasmid sensillum pore. WB:WBPaper00000938 WB:WBPaper00004350 WB:WBPaper00026656 WB:WBPerson712 Animals display variations in the structure, organization or path of the part of the axon that forms a bridge between body regions, compared to that in control animals. commissure abnormal C_elegans_phenotype_ontology WBPhenotype:0001226 commissure variant Animals display variations in the structure, organization or path of the part of the axon that forms a bridge between body regions, compared to that in control animals. WB:WBPaper00000938 WB:WBPaper00001576 WB:WBPaper00029065 WB:WBPerson712 Animals are missing any one of its commissures, an axon tract that connects one body part to another. C_elegans_phenotype_ontology WBPhenotype:0001227 commissure absent Animals are missing any one of its commissures, an axon tract that connects one body part to another. WB:WBPaper00027335 WB:WBPerson712 Animals lack the small linear ridges running along the lateral lines of the cuticle, lengthwise along the body (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0001228 alae absent Animals lack the small linear ridges running along the lateral lines of the cuticle, lengthwise along the body (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The orderly movement of neurons along the anterior axis of the animal is abolished, misdirected or incomplete compared to control. abnormal anterior neuron migration C_elegans_phenotype_ontology WBPhenotype:0001229 anterior neuron migration defective The orderly movement of neurons along the anterior axis of the animal is abolished, misdirected or incomplete compared to control. WB:WBPerson2021 The orderly movement of cells along the anterior axis of the animal is abolished, misdirected or incomplete compared to control. abnormal anterior cell migration C_elegans_phenotype_ontology WBPhenotype:0001230 anterior cell migration defective The orderly movement of cells along the anterior axis of the animal is abolished, misdirected or incomplete compared to control. WB:WBPerson2021 The rate, frequency or extent of bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is increased compared to control. C_elegans_phenotype_ontology ift accelerated WBPhenotype:0001231 intraflagellar transport accelerated The rate, frequency or extent of bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is increased compared to control. WB:WBPerson2021 Animals exhibit variations in the response to the addition of serotonin compared to that observed in control animals. Serotonin is a monoamine neurotransmitter. serotonin response abnormal C_elegans_phenotype_ontology WBPhenotype:0001232 serotonin response variant Animals exhibit variations in the response to the addition of serotonin compared to that observed in control animals. Serotonin is a monoamine neurotransmitter. WB:WBPerson557 Animals exhibit variations in the pattern of a chemical nuclear stain which is commonly used in fixed specimens and produces a bright blue label, compared to control. DAPI (4'-6-Diamidino-2-phenylindole) forms fluorescent complexes with natural double-stranded DNA (Wormatlas). DAPI staining abnormal C_elegans_phenotype_ontology WBPhenotype:0001233 DAPI staining variant Animals exhibit variations in the pattern of a chemical nuclear stain which is commonly used in fixed specimens and produces a bright blue label, compared to control. DAPI (4'-6-Diamidino-2-phenylindole) forms fluorescent complexes with natural double-stranded DNA (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Failure to execute the characteristic response to nonanone compared to control. In C. elegans, nonanone is a repellant. C_elegans_phenotype_ontology WBPhenotype:0001234 nonanone chemotaxis defective Failure to execute the characteristic response to nonanone compared to control. In C. elegans, nonanone is a repellant. WB:WBPaper00002917 Any variation in the orientation of the physical partitioning and separation of a cell into daughter cells compared to control. cell division polarity abnormal C_elegans_phenotype_ontology WBPhenotype:0001235 cell division polarity variant Any variation in the orientation of the physical partitioning and separation of a cell into daughter cells compared to control. WB:WBPerson2021 WB:WBPerson557 Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals. C_elegans_phenotype_ontology WBPhenotype:0001236 transgene expression increased Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals. WB:WBPerson557 Any perturbation that causes an increase in the frequency of axon outgrowth compared to control. As a result, an excess number of axonal projections are generated. C_elegans_phenotype_ontology WBPhenotype:0001237 excess axon outgrowth Any perturbation that causes an increase in the frequency of axon outgrowth compared to control. As a result, an excess number of axonal projections are generated. GO:0030517 WB:WBPerson2021 Any variation in the length of time required for a male to find a mate and initiate the search for the vulva. In C. elegans, the latency period includes the time males spend to find a hermaphrodite and pause to press its ventral side against the surface of the hermaphrodite and initiate a backing up search for the vulva. male mating latency abnormal C_elegans_phenotype_ontology WBPhenotype:0001238 male mating latency variant Any variation in the length of time required for a male to find a mate and initiate the search for the vulva. In C. elegans, the latency period includes the time males spend to find a hermaphrodite and pause to press its ventral side against the surface of the hermaphrodite and initiate a backing up search for the vulva. WB:cab pmid:16624900 Any increase in the length of time required for a male to find a mate and initiate the search for the vulva. In C. elegans, the latency period includes the time males spend to find a hermaphrodite and pause to press its ventral side against the surface of the hermaphrodite and initiate a backing up search for the vulva. C_elegans_phenotype_ontology WBPhenotype:0001239 mating latency increased Any increase in the length of time required for a male to find a mate and initiate the search for the vulva. In C. elegans, the latency period includes the time males spend to find a hermaphrodite and pause to press its ventral side against the surface of the hermaphrodite and initiate a backing up search for the vulva. pmid:16624900 Variations in the processes leading to the specialization of the finger-like sensory sensilla that project from the tail and embed in the male fan compared to control. male tail sensory ray differentiation abnormal C_elegans_phenotype_ontology WBPhenotype:0001240 male tail sensory ray differentiation variant Variations in the processes leading to the specialization of the finger-like sensory sensilla that project from the tail and embed in the male fan compared to control. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0001241 obsolete ray fusion true The rate, frequency or extent of bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is lower compared to control. C_elegans_phenotype_ontology WBPhenotype:0001242 intraflagellar transport slow The rate, frequency or extent of bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is lower compared to control. WB:WBPerson2021 The bidirectional transport of molecules (cargo) along axonemal microtubules is reduced compared to control. C_elegans_phenotype_ontology WBPhenotype:0001243 intraflagellar transport distance short The bidirectional transport of molecules (cargo) along axonemal microtubules is reduced compared to control. WB:WBPerson2021 WB:WBPerson557 Bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is completely abolished. C_elegans_phenotype_ontology WBPhenotype:0001244 intraflagellar transport absent Bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is completely abolished. WB:WBPerson2021 The bidirectional transport of molecules along the middle segment of axonemal microtubules of the cilia is absent. C_elegans_phenotype_ontology WBPhenotype:0001245 no transport middle segment cilia The bidirectional transport of molecules along the middle segment of axonemal microtubules of the cilia is absent. WB:WBPerson2021 WB:WBPerson557 The bidirectional transport of molecules along the distal segment of axonemal microtubules of the cilia is absent. C_elegans_phenotype_ontology WBPhenotype:0001246 no transport distal segment cilia The bidirectional transport of molecules along the distal segment of axonemal microtubules of the cilia is absent. WB:WBPerson2021 WB:WBPerson557 The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons is disrupted. C_elegans_phenotype_ontology WBPhenotype:0001247 Possible XP. anterograde transport defective The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons is disrupted. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the structure or organization of the microtuble-based projections that in control animals invaginate individually into the sheath cell of the neuronal sensillum rather than projecting through the socket cell to the outside. In C. elegans, the cilia of each wing cell has its own unique shape and as they are not exposed to the outside, they do not typically take up dyes. wing cilia morphology abnormal C_elegans_phenotype_ontology AWC cilia morphology abnormal WBPhenotype:0001248 wing cilia morphology variant Animals exhibit variations in the structure or organization of the microtuble-based projections that in control animals invaginate individually into the sheath cell of the neuronal sensillum rather than projecting through the socket cell to the outside. In C. elegans, the cilia of each wing cell has its own unique shape and as they are not exposed to the outside, they do not typically take up dyes. WB:WBPaper00000932 WB:WBPaper00029016 WB:WBPerson712 Animals exhibit variations in the structure or composition of the dendritic projections of the amphid sensory neurons that traverse the sensillum pore to connect with the outside of the animal, compared to that observed in control animals. In C. elegans, amphid channel cilia morphology is frequently assayed by dye-filling experiments using FITC, DiI or DiO. amphid channel cilia morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001249 amphid channel cilia morphology variant Animals exhibit variations in the structure or composition of the dendritic projections of the amphid sensory neurons that traverse the sensillum pore to connect with the outside of the animal, compared to that observed in control animals. In C. elegans, amphid channel cilia morphology is frequently assayed by dye-filling experiments using FITC, DiI or DiO. WB:WBPaper00000932 WB:WBPerson712 Animals exhibit variations in the structure or composition of the microtuble-based fibrillar core, axoneme, of the cilia of the neurons that project through the sensillum pore to the outside of the animal, compared to that observed in control animals. amphid channel axoneme morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001250 amphid channel axoneme morphology variant Animals exhibit variations in the structure or composition of the microtuble-based fibrillar core, axoneme, of the cilia of the neurons that project through the sensillum pore to the outside of the animal, compared to that observed in control animals. WB:WBPaper00000932 WB:WBPerson557 WB:WBPerson712 The microtuble-based fibrillar-bundles of the amphid sensory cilia are reduced in length compared to those in control animals. C_elegans_phenotype_ontology WBPhenotype:0001251 amphid channel axoneme short The microtuble-based fibrillar-bundles of the amphid sensory cilia are reduced in length compared to those in control animals. WB:WBPaper00000932 WB:WBPaper00027116 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in the structure or organization of the microtubule-based fibrillar section, axoneme, of the cilia of the flat sheet-like cells associated with sensory function, from that observed in control animals. wing cilia axoneme morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001252 wing cilia axoneme morphology variant Animals exhibit variations in the structure or organization of the microtubule-based fibrillar section, axoneme, of the cilia of the flat sheet-like cells associated with sensory function, from that observed in control animals. WB:WBPerson712 The microtuble-based fibrillar-bundle, axoneme, of the wing cell cilia are reduced in length and do not extend into the sheath cell as far as they do in control animals. C_elegans_phenotype_ontology WBPhenotype:0001253 wing cilia axoneme short The microtuble-based fibrillar-bundle, axoneme, of the wing cell cilia are reduced in length and do not extend into the sheath cell as far as they do in control animals. WB:WBPerson712 The dendritic processes that normally extend through the amphid sensillum pore to the outside are truncated and have swollen ends as opposed to the extended and finger-like tips of channel cilia in control animals. C_elegans_phenotype_ontology WBPhenotype:0001254 amphid channel cilia bulbous The dendritic processes that normally extend through the amphid sensillum pore to the outside are truncated and have swollen ends as opposed to the extended and finger-like tips of channel cilia in control animals. WB:WBPaper00027116 WB:WBPerson712 Animals exhibit wing cell sensory cilia that are truncated and swollen unlike that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001255 wing cilia bulbous Animals exhibit wing cell sensory cilia that are truncated and swollen unlike that observed in control animals. WB:WBPaper00027116 WB:WBPerson712 Variations in the aggregation of molecules at the site of DNA strand breakage or damage compared to control. DNA damage induced focus formation abnormal C_elegans_phenotype_ontology DNA repair induced focus formation WBPhenotype:0001256 DNA damage induced focus formation variant Variations in the aggregation of molecules at the site of DNA strand breakage or damage compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the generation of foci that mark sites of aberrant bonding of molecules to the DNA strand, compared to control. cross link induced focus formation abnormal C_elegans_phenotype_ontology WBPhenotype:0001257 cross link induced focus formation variant Variations in the generation of foci that mark sites of aberrant bonding of molecules to the DNA strand, compared to control. WB:WBPerson2021 WB:WBPerson557 Animals show increased susceptibility to gene silencing triggered by double stranded RNA (RNAi), compared to control. C_elegans_phenotype_ontology Eri WBPhenotype:0001258 RNAi enhanced Animals show increased susceptibility to gene silencing triggered by double stranded RNA (RNAi), compared to control. WB:WBPerson2021 Hermaphrodites exhibit a reduction in the production of new individuals owing to defects in gamete competence and/or function compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001259 hermaphrodite fertility reduced Hermaphrodites exhibit a reduction in the production of new individuals owing to defects in gamete competence and/or function compared to control animals. WB:WBPerson2021 WB:WBPerson557 Haploid female germ cells (oocytes) exhibit variations in their overall structure, appearance or contents compared to control. oocyte morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001260 oocyte morphology variant Haploid female germ cells (oocytes) exhibit variations in their overall structure, appearance or contents compared to control. WB:WBPaper00001883 WB:WBPerson2021 Animals show deficiencies in chroma resulting in increased translucency. C_elegans_phenotype_ontology WBPhenotype:0001261 pale Animals show deficiencies in chroma resulting in increased translucency. WB:WBPerson2021 WB:WBPerson557 The developmental progression of the egg-laying organ of female and hermaphrodite nematodes is halted prior to the formation of the mature structure. C_elegans_phenotype_ontology WBPhenotype:0001262 vulval development incomplete The developmental progression of the egg-laying organ of female and hermaphrodite nematodes is halted prior to the formation of the mature structure. WB:WBPerson2021 WB:WBPerson557 The morphological appearance of peroxisomes is variant compared to control animals. peroxisome morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001263 peroxisome morphology variant The morphological appearance of peroxisomes is variant compared to control animals. WB:cab Animals exhibit variations in any physical or chemical process required for the peroxisome to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. peroxisome physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001264 peroxisome physiology variant Animals exhibit variations in any physical or chemical process required for the peroxisome to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson712 The anterior portion of the animal exhibits variations in its movement compared to control. Erratic head vibration head movement abnormal C_elegans_phenotype_ontology WBPhenotype:0001265 head movement variant The anterior portion of the animal exhibits variations in its movement compared to control. WB:WBPaper00000214 Any variation in triggering of the set of interactions occurring between a group of genes who depend on each other's individual functions in order to make the aggregate function of the network available to the cell, compared to control. genetic pathway activation abnormal C_elegans_phenotype_ontology WBPhenotype:0001266 genetic pathway activation variant Any variation in triggering of the set of interactions occurring between a group of genes who depend on each other's individual functions in order to make the aggregate function of the network available to the cell, compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the frequency of gonad sheath contractions triggered by internal or external stimuli compared to control. induced contraction rate abnormal C_elegans_phenotype_ontology WBPhenotype:0001267 induced contraction rate variant Any variation in the frequency of gonad sheath contractions triggered by internal or external stimuli compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the extent of activation of programmed cell death, compared to control. induced cell death abnormal C_elegans_phenotype_ontology WBPhenotype:0001268 induced cell death variant Animals exhibit variations in the extent of activation of programmed cell death, compared to control. WB:WBPerson712 Animals exhibit variations in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control. pathogen induced cell death abnormal C_elegans_phenotype_ontology WBPhenotype:0001269 pathogen induced cell death variant Animals exhibit variations in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control. WB:WBPerson712 Animals exhibit a decrease in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001270 pathogen induced cell death reduced Animals exhibit a decrease in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control. WB:WBPerson712 Animals are more prone to lethality as a result of infection compared to control. C_elegans_phenotype_ontology WBPhenotype:0001271 pathogen induced death increased Animals are more prone to lethality as a result of infection compared to control. WB:WBPerson2021 WB:WBPerson557 Vulval precursor cells inappropriately adopt fates that are normally restricted to other vulval precursor cells compared to control. vulval precursor cell induction abnormal vulval cell induction abnormal C_elegans_phenotype_ontology WBPhenotype:0001272 vulval cell induction variant Vulval precursor cells inappropriately adopt fates that are normally restricted to other vulval precursor cells compared to control. WB:WBPerson2021 Any variation in the state or activity of an organism (in terms of movement, gene expression, etc.) in response to heat (high temperatures above the optimal temperature for that organism), compared to control. organism heat response abnormal C_elegans_phenotype_ontology WBPhenotype:0001273 organism heat response variant Any variation in the state or activity of an organism (in terms of movement, gene expression, etc.) in response to heat (high temperatures above the optimal temperature for that organism), compared to control. GO:0009408 WB:WBPerson2021 Animals respond to heat at a lower temperature or a shorter exposure time compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001274 organism heat hypersensitive Animals respond to heat at a lower temperature or a shorter exposure time compared to control animals. WB:WBPerson557 Any variation that increases the magnitude of a signal generated by a set of gene interactions in a given pathway, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001275 increased genetic pathway signal Any variation that increases the magnitude of a signal generated by a set of gene interactions in a given pathway, compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the cellular expression of a gene product produced by exogenous DNA that has been introduced into the organism such that it now expresses in cells/tissues not seen when compared to the expression of that gene product in control animals. C_elegans_phenotype_ontology WBPhenotype:0001276 ectopic expression transgene Any variation in the cellular expression of a gene product produced by exogenous DNA that has been introduced into the organism such that it now expresses in cells/tissues not seen when compared to the expression of that gene product in control animals. WB:WBPerson557 XX animals are transformed into males or pseudomales . C_elegans_phenotype_ontology Tra WBPhenotype:0001277 transformer XX animals are transformed into males or pseudomales . WB:WBPerson712 WB:cab Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals. C_elegans_phenotype_ontology WBPhenotype:0001278 transgene expression reduced Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals. WB:WBPerson557 Any decrease in the intensity of expression of a gene product produced by exogenous DNA, exclusively in the male, that has been introduced into the organism compared to its expression in control animals. C_elegans_phenotype_ontology WBPhenotype:0001279 transgene expression reduced male Any decrease in the intensity of expression of a gene product produced by exogenous DNA, exclusively in the male, that has been introduced into the organism compared to its expression in control animals. WB:WBPerson557 Any decrease in the intensity of expression of a gene product produced by exogenous DNA, exclusively in the hermaphrodite, that has been introduced into the organism compared to its expression in control animals. C_elegans_phenotype_ontology WBPhenotype:0001280 transgene expression reduced hermaphrodite Any decrease in the intensity of expression of a gene product produced by exogenous DNA, exclusively in the hermaphrodite, that has been introduced into the organism compared to its expression in control animals. WB:WBPerson557 Pharynx becomes clogged with food. In C. elegans, this is often a result of pharyngeal pumping defects. C_elegans_phenotype_ontology WBPhenotype:0001281 stuffed pharynx Pharynx becomes clogged with food. In C. elegans, this is often a result of pharyngeal pumping defects. WB:cab Variations in the chemical reactions and pathways of the mitochondria compared to control. mitochondrial metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0001282 mitochondrial metabolism variant Variations in the chemical reactions and pathways of the mitochondria compared to control. WB:WBPerson2021 Variations in the chemical reactions and pathways of an organelle compared to control. organelle metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0001283 organelle metabolism variant Variations in the chemical reactions and pathways of an organelle compared to control. WB:WBPerson2021 Animals contain a lower level of coenzyme Q, an oil-soluble vitamin-like substance present in most eukaryotic cells, primarily in the mitochondria, compared to control. It is a component of the electron transport chain and participates in aerobic cellular respiration. C_elegans_phenotype_ontology WBPhenotype:0001284 coenzyme Q depleted Animals contain a lower level of coenzyme Q, an oil-soluble vitamin-like substance present in most eukaryotic cells, primarily in the mitochondria, compared to control. It is a component of the electron transport chain and participates in aerobic cellular respiration. WB:WBPerson2021 WB:WBPerson557 Pharyngeal pumping is not influenced by treatment with specific compounds (eg: serotonin) in the same manner as control animals. induced pharyngeal pumping abnormal C_elegans_phenotype_ontology WBPhenotype:0001285 induced pharyngeal pumping variant Pharyngeal pumping is not influenced by treatment with specific compounds (eg: serotonin) in the same manner as control animals. WB:WBPerson2021 Exposure to food does not reduce pharyngeal pumping to the same extent as observed in control animals. food suppressed pumping abnormal C_elegans_phenotype_ontology WBPhenotype:0001286 food suppressed pumping variant Exposure to food does not reduce pharyngeal pumping to the same extent as observed in control animals. WB:WBPerson2021 Animals do not exhibit a decrease in pumping rate when treated with specific compounds (such as pheromones) as is observed for control animals. suppressed pharyngeal pumping abnormal C_elegans_phenotype_ontology WBPhenotype:0001287 suppressed pharyngeal pumping defective Animals do not exhibit a decrease in pumping rate when treated with specific compounds (such as pheromones) as is observed for control animals. WB:WBPaper00032082 WB:WBPerson712 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0001288 is alternative id for "locomotion reduced" (WBPhenotype:0001213); may have originally had term name "movement reduced" true Animals fail to respond to the concentration of acetylcholinesterase inhibitor that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001289 acetylcholinesterase inhibitor resistant Animals fail to respond to the concentration of acetylcholinesterase inhibitor that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals exhibit variations in their response to a specific acetylcholinesterase inhibitor compared to that observed in control animals. acetylcholinesterase inhibitor response abnormal C_elegans_phenotype_ontology WBPhenotype:0001290 acetylcholinesterase inhibitor response variant Animals exhibit variations in their response to a specific acetylcholinesterase inhibitor compared to that observed in control animals. WB:WBPerson557 Animals exhibit variations in actions and responses that occurs predominantly, or only, in individuals that are part of a group, from that observed for animals in a control group. social behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0001291 social behavior variant Animals exhibit variations in actions and responses that occurs predominantly, or only, in individuals that are part of a group, from that observed for animals in a control group. GO:0035176 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the body wall muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. body wall muscle physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001292 body wall muscle physiology variant Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the body wall muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for the larva to carry out its normal metabolic functions or activities or be able to perceive and respond to stimuli, compared to control animals. larval physiology abnormal larval physiology variant C_elegans_phenotype_ontology WBPhenotype:0001293 larval physiology phenotype Animals exhibit variations in any physical or chemical process required for the larva to carry out its normal metabolic functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson712 The most anterior portion of the animal is not aligned with the axis of the body. C_elegans_phenotype_ontology WBPhenotype:0001294 head bent The most anterior portion of the animal is not aligned with the axis of the body. WB:WBPaper00000031 Any portion of the animal, between the head and the tail, appears distorted, usually due to uncharacteristic winding. C_elegans_phenotype_ontology WBPhenotype:0001295 body twisted Any portion of the animal, between the head and the tail, appears distorted, usually due to uncharacteristic winding. WB:WBPerson2021 WB:WBPerson557 Animals fail to respond to the concentration of lannate that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. methomyl resistant C_elegans_phenotype_ontology WBPhenotype:0001296 lannate resistant Animals fail to respond to the concentration of lannate that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Any variation in the process whose specific outcome is the progression of the male tail over time, from its formation to the mature structure, compared to control. male tail development abnormal C_elegans_phenotype_ontology WBPhenotype:0001297 male tail development variant Any variation in the process whose specific outcome is the progression of the male tail over time, from its formation to the mature structure, compared to control. WB:WBPerson2021 Animals exhibit variations in the form, structure or composition of the more posterior portion of the intestine, just anterior to the sphincter valve, which is subject to squeezing by the somatal-intestinal muscles compared to control animals (Wormatlas). hindgut morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001298 hindgut morphology variant Animals exhibit variations in the form, structure or composition of the more posterior portion of the intestine, just anterior to the sphincter valve, which is subject to squeezing by the somatal-intestinal muscles compared to control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation that alters the physical partitioning and separation of a cell into daughter cells in male animals compared to control. cell division abnormal C_elegans_phenotype_ontology WBPhenotype:0001299 cell division variant male Any variation that alters the physical partitioning and separation of a cell into daughter cells in male animals compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the composition or structure of the contents within a germ cell, excluding the plasma membrane and nucleus, compared to control. Germ cells include sperm, oocytes, and their precursors. germ cell cytoplasmic morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001300 germ cell cytoplasmic morphology variant Any variation in the composition or structure of the contents within a germ cell, excluding the plasma membrane and nucleus, compared to control. Germ cells include sperm, oocytes, and their precursors. GO:0005737 WB:WBPerson2021 WB:WBPerson557 Localization or structural appearance of P-granules is altered compared to control. P-granules are cytoplasmic structures associated with germ nuclei in the C. elegans gonad, and are localized exclusively to germ cells, or germ cell precursors, throughout the life cycle. C_elegans_phenotype_ontology WBPhenotype:0001301 P granule abnormal Localization or structural appearance of P-granules is altered compared to control. P-granules are cytoplasmic structures associated with germ nuclei in the C. elegans gonad, and are localized exclusively to germ cells, or germ cell precursors, throughout the life cycle. WB:cab pmid:11262230 The restricted localization of P granules to germ cells or germ cell precursors is altered compared to control. P granule localization abnormal C_elegans_phenotype_ontology germ granule localization defective WBPhenotype:0001302 P granule localization defective The restricted localization of P granules to germ cells or germ cell precursors is altered compared to control. WB:WBPaper00001477 WB:WBPerson2021 Animals have one or more extra cells of a particular type, which are present in places they are normally not found, when compared to the number and location of these cells in control animals. C_elegans_phenotype_ontology WBPhenotype:0001303 extra and ectopic cell Animals have one or more extra cells of a particular type, which are present in places they are normally not found, when compared to the number and location of these cells in control animals. WB:WBPerson2021 WB:WBPerson557 The terminal portion of the intestine exhibits structural defects such as scarring or blockage. Scar C_elegans_phenotype_ontology WBPhenotype:0001304 hindgut damaged The terminal portion of the intestine exhibits structural defects such as scarring or blockage. WB:WBPaper00003719 WB:cab Any variation in the form or composition of the structure that lies on the ventral surface just anterior and central to the base of the spicule openings (small lump on the gubernaculum of the male tail) and contains a sensory structure called the hook sensillum, compared to control. In C. elegans the hook is necessary for proper male mating. hook morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001305 hook morphology variant Any variation in the form or composition of the structure that lies on the ventral surface just anterior and central to the base of the spicule openings (small lump on the gubernaculum of the male tail) and contains a sensory structure called the hook sensillum, compared to control. In C. elegans the hook is necessary for proper male mating. WB:WBPerson2021 WB:WBPerson557 Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the male reproductive system compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents. male reproductive system morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001306 male reproductive system morphology variant Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the male reproductive system compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents. WB:WBPerson2021 WB:WBPerson557 The maximum ventral and dorsal flex of the animal is reduced compared to that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0001307 reduced body bend The maximum ventral and dorsal flex of the animal is reduced compared to that observed for control animals. WB:WBPerson2021 WB:WBPerson557 The contraction and relaxation movements of the pharyngeal muscle that mediate feeding is not as robust as compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001308 weak pumping The contraction and relaxation movements of the pharyngeal muscle that mediate feeding is not as robust as compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit a decrease in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control. WBPhenotype:0000003 amplitude of body bends decreased flat locomotion path flattened locomotion path C_elegans_phenotype_ontology WBPhenotype:0001309 amplitude of sinusoidal movement decreased Animals exhibit a decrease in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control. WB:WBPaper00043908 WB:WBPerson2021 WB:WBPerson2987 WB:WBPerson557 The placement of neuronal cells, as a whole or of a specific class of neuron in the animal, deviates from that observed in control animals. neuron positioning abnormal C_elegans_phenotype_ontology WBPhenotype:0001310 neuron positioning variant The placement of neuronal cells, as a whole or of a specific class of neuron in the animal, deviates from that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Variations that result in a decrease in protein expression in hermaphrodites compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001311 protein expression reduced hermaphrodite Variations that result in a decrease in protein expression in hermaphrodites compared to that observed in control animals. WB:WBPerson2021 The quantity of neuronal cells, as a whole or of a specific class of neuron in the animal deviates from that observed in control animals. neuron number abnormal C_elegans_phenotype_ontology WBPhenotype:0001312 neuron number variant The quantity of neuronal cells, as a whole or of a specific class of neuron in the animal deviates from that observed in control animals. WB:WBPaper00027711 WB:WBPerson712 Any variation in the progression of the sex-specific muscles of the hermaphrodite, over time, whose contractions squeeze on the uterus to help move eggs towards the vulval opening compared to control (Wormatlas). uterine muscle abnormal C_elegans_phenotype_ontology WBPhenotype:0001313 uterine muscle variant Any variation in the progression of the sex-specific muscles of the hermaphrodite, over time, whose contractions squeeze on the uterus to help move eggs towards the vulval opening compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the sex-specific muscles in the hermaphrodite, over time, that are specialized for egg-laying compared to control. In C. elegans the contractions of the vulval muscles open the lips of the vulva to help in expelling an egg from the uterus (Wormatlas). vulval muscle abnormal C_elegans_phenotype_ontology WBPhenotype:0001314 vulval muscle variant Any variation in the progression of the sex-specific muscles in the hermaphrodite, over time, that are specialized for egg-laying compared to control. In C. elegans the contractions of the vulval muscles open the lips of the vulva to help in expelling an egg from the uterus (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the electrical properties of any of its cells or tissues compared to control. electrophysiology abnormal electrophysiology variant C_elegans_phenotype_ontology WBPhenotype:0001315 electrophysiology phenotype Animals exhibit variations in the electrical properties of any of its cells or tissues compared to control. WB:WBPerson2021 Variations in the synaptic currents that are elicited by firing an action potential in a population of axons, compared to control. evoked postsynaptic current abnormal C_elegans_phenotype_ontology WBPhenotype:0001316 evoked postsynaptic current variant Variations in the synaptic currents that are elicited by firing an action potential in a population of axons, compared to control. WB:WBPerson2021 pmid:14735116 The amplitudes of synaptic currents that are elicited by firing an action potential in a population of axons are decreased, compared to those observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001317 evoked postsynaptic amplitude reduced The amplitudes of synaptic currents that are elicited by firing an action potential in a population of axons are decreased, compared to those observed in control animals. WB:WBPerson2021 Any variation in the currents observed in the absence of presynaptic action potentials and that are elicited by fusion of a single endogenous vesicle of transmitter compared to control. endogenous synaptic events abnormal C_elegans_phenotype_ontology WBPhenotype:0001318 endogenous synaptic events variant Any variation in the currents observed in the absence of presynaptic action potentials and that are elicited by fusion of a single endogenous vesicle of transmitter compared to control. WB:WBPerson2021 pmid:14735116 The rate (frequency) of currents elicited by fusion of a single endogenous vesicle of transmitter in the absence of presynaptic action potentials is decreased compared to control. Changes in frequency are indicative of presynaptic modifications. C_elegans_phenotype_ontology WBPhenotype:0001319 endogenous synaptic event frequency reduced The rate (frequency) of currents elicited by fusion of a single endogenous vesicle of transmitter in the absence of presynaptic action potentials is decreased compared to control. Changes in frequency are indicative of presynaptic modifications. WB:WBPaper00026938 WB:WBPerson2021 pmid:14735116 The amplitude (magnitude) of currents elicited by fusion of a single endogenous vesicle of transmitter in the absence of presynaptic action potentials is altered compared to control. Changes in amplitude are often interpreted as alterations of postsynaptic responsiveness to the transmitter. endogenous synaptic amplitude abnormal C_elegans_phenotype_ontology WBPhenotype:0001320 endogenous synaptic amplitude variant The amplitude (magnitude) of currents elicited by fusion of a single endogenous vesicle of transmitter in the absence of presynaptic action potentials is altered compared to control. Changes in amplitude are often interpreted as alterations of postsynaptic responsiveness to the transmitter. WB:WBPerson2021 pmid:14735116 Animals display variations in the structure, configuration, distribution or ratio of the components of the vesicle-filled varicosities of the synapse compared to control. presynaptic region morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001321 presynaptic region morphology variant Animals display variations in the structure, configuration, distribution or ratio of the components of the vesicle-filled varicosities of the synapse compared to control. GO:0042734 WB:WBPaper00000938 WB:WBPaper00027305 WB:WBPaper00028886 WB:WBPerson712 OBSOLETE. Total presynaptic vesicle number is reduced, possibly refecting a defect in the replenishment of synaptic vesicles compared to control. C_elegans_phenotype_ontology WBPhenotype:0001322 Electron microscopic analysis. obsolete vesicle number reduced true OBSOLETE. Total presynaptic vesicle number is reduced, possibly refecting a defect in the replenishment of synaptic vesicles compared to control. WB:cab pmid:16803962 Animals display variations in the shape or size of their vesicles, which are spherical, membrane-bound fluid-filled organelles, compared to vesicles observed in control animals. vesicle morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001323 Electron microscopic analysis. vesicle morphology variant Animals display variations in the shape or size of their vesicles, which are spherical, membrane-bound fluid-filled organelles, compared to vesicles observed in control animals. GO:0031982 WB:WBPaper00027612 WB:WBPaper00027711 WB:WBPerson712 WB:cab pmid:16803962 Cells exhibit variations in their response to ionizing radiation compared to that observed in control animals. cell ionizing radiation response abnormal C_elegans_phenotype_ontology WBPhenotype:0001324 cell ionizing radiation response variant Cells exhibit variations in their response to ionizing radiation compared to that observed in control animals. WB:WBPerson557 Animals initiate but do not continue backward movement, similar to control animals. C_elegans_phenotype_ontology WBPhenotype:0001325 backing not sustained Animals initiate but do not continue backward movement, similar to control animals. WB:cab WB:cgc914 Cells exhibit variations in their response to gamma ray radiation compared to that observed in control animals. cell gamma ray response abnormal C_elegans_phenotype_ontology WBPhenotype:0001326 cell gamma ray response variant Cells exhibit variations in their response to gamma ray radiation compared to that observed in control animals. WB:WBPerson557 Cells respond to a lower dosage of gamma rays or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001327 cell gamma ray hypersensitive Cells respond to a lower dosage of gamma rays or a shorter exposure compared to control animals. WB:WBPerson557 The posterior part of the worm is shorter and stouter compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001328 posterior body dumpy The posterior part of the worm is shorter and stouter compared to control animals. WB:WBPerson557 Animals exhibit a greater number of bends in their body compared to control. C. elegans posture assumes more than a single sine wave. C_elegans_phenotype_ontology WBPhenotype:0001329 curly Animals exhibit a greater number of bends in their body compared to control. C. elegans posture assumes more than a single sine wave. WB:cab WB:cgc914 The rate of the intrinsic behavioral program that serves to move fertilized eggs down the uterus, through the vulva, and out of the worm onto the substrate is reduced compared to that observed in control animals (Wormatlas). C_elegans_phenotype_ontology egg laying event rare WBPhenotype:0001330 egg laying event infrequent The rate of the intrinsic behavioral program that serves to move fertilized eggs down the uterus, through the vulva, and out of the worm onto the substrate is reduced compared to that observed in control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals display variations in the structure or organization of components of the motor neuron, internal to the cell itself or in relation to the cellular environment compared to that observed in control animals. A motor neuron is a neuronal cell that synapses to an effector (muscle, gland etc.). motor neuron morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001331 WBbt:0005409. motor neuron morphology variant Animals display variations in the structure or organization of components of the motor neuron, internal to the cell itself or in relation to the cellular environment compared to that observed in control animals. A motor neuron is a neuronal cell that synapses to an effector (muscle, gland etc.). WB:WBPerson712 Animals display variations in the number of spherical membrane-bound fluid-filled organelles, compared to that observed in control animals. vesicle number abnormal C_elegans_phenotype_ontology WBPhenotype:0001332 vesicle number variant Animals display variations in the number of spherical membrane-bound fluid-filled organelles, compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 The body of a neuron is not where it should be when compared to control animals; it is absent or misplaced. C_elegans_phenotype_ontology WBPhenotype:0001333 neuron cell body absent misplaced The body of a neuron is not where it should be when compared to control animals; it is absent or misplaced. WB:WBPaper00000502 WB:WBPaper00000635 WB:WBPerson712 Any variation in the form, structure or composition of the muscles of the adult hermaphrodite reproductive system compared to control. In C. elegans hermaphrodites these muscles include the vulval and uterine muscles, located near the vulva in the midbody, which all derive from the M myoblast (Wormatlas). hermaphrodite sex muscle morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001334 hermaphrodite sex muscle morphology variant Any variation in the form, structure or composition of the muscles of the adult hermaphrodite reproductive system compared to control. In C. elegans hermaphrodites these muscles include the vulval and uterine muscles, located near the vulva in the midbody, which all derive from the M myoblast (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the hermaphrodite reproductive system, compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents. hermaphrodite reproductive system morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001335 hermaphrodite reproductive system morphology variant Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the hermaphrodite reproductive system, compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents. WB:WBPerson2021 WB:WBPerson557 Males sire no cross progeny. no male progeny C_elegans_phenotype_ontology WBPhenotype:0001336 male mating efficiency eliminated Males sire no cross progeny. WB:WBPaper00000179 WB:WBPaper00000608 WB:WBPerson557 Animals exhibit variations in their response to a specific adrenergic receptor antagonist compared to that observed in control animals. adrenergic receptor antagonist response abnormal C_elegans_phenotype_ontology WBPhenotype:0001337 adrenergic receptor antagonist response variant Animals exhibit variations in their response to a specific adrenergic receptor antagonist compared to that observed in control animals. WB:WBPerson557 Animals fail to respond to the concentration of phentolamine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001338 phentolamine resistant Animals fail to respond to the concentration of phentolamine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals are not induced to lay eggs in reponse to exogenous levamisole. In C. elegans, levamisole stimulates egg-laying. C_elegans_phenotype_ontology WBPhenotype:0001339 egg laying levamisole resistant Animals are not induced to lay eggs in reponse to exogenous levamisole. In C. elegans, levamisole stimulates egg-laying. WB:WBPaper00000635 WB:WBPerson712 Animals are not induced to lay eggs in reponse to exogenous imipramine. In C. elegans, imipramine stimulates egg-laying. C_elegans_phenotype_ontology WBPhenotype:0001340 egg laying imipramine resistant Animals are not induced to lay eggs in reponse to exogenous imipramine. In C. elegans, imipramine stimulates egg-laying. WB:WBPaper00000635 WB:WBPaper00001133 WB:WBPaper00031293 WB:WBPerson712 Animals are not induced to lay eggs in reponse to exogenous phentolamine. In C. elegans, phentolamine stimulates egg-laying. C_elegans_phenotype_ontology WBPhenotype:0001341 egg laying phentolamine resistant Animals are not induced to lay eggs in reponse to exogenous phentolamine. In C. elegans, phentolamine stimulates egg-laying. WB:WBPaper00000635 WB:WBPerson712 Animals respond to exogenous imipramine at a lower concentration or within a shorter time period than control animals under the same conditions. C_elegans_phenotype_ontology WBPhenotype:0001342 egg laying imipramine hypersensitive Animals respond to exogenous imipramine at a lower concentration or within a shorter time period than control animals under the same conditions. WB:WBPaper00000635 WB:WBPerson712 Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle during a meiotic cell cycle. C_elegans_phenotype_ontology WBPhenotype:0001343 Possible XP. meiotic spindle defective early emb Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle during a meiotic cell cycle. GO:0000212 WB:WBPerson2021 Intracellular membrane bound compartments vary in shape or size from that observed in control animals. organelle organization biogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0001344 organelle organization biogenesis variant Intracellular membrane bound compartments vary in shape or size from that observed in control animals. WB:WBPaper00032168 WB:WBPerson712 Animals exhibit variations in the form, structure, composition or arrangement of any of the various filamentous elements that form the internal framework of cells, compared to control. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. cytoskeleton organization biogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0001345 cytoskeleton organization biogenesis variant Animals exhibit variations in the form, structure, composition or arrangement of any of the various filamentous elements that form the internal framework of cells, compared to control. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. GO:0005856 WB:WBPerson2021 WB:WBPerson557 Any variation in the dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins compared to control. actin cytoskeleton dynamics variant actin cytoskeleton dynamic abnormal C_elegans_phenotype_ontology WBPhenotype:0001346 Possible XP. actin cytoskeleton dynamics phenotype Any variation in the dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins compared to control. GO:0031532 WB:WBPerson2021 WB:WBPerson557 Any variation in the series of molecular signals in which an intestinal cell uses calcium ions to convert an extracellular signal into a response, compared to control. intestinal calcium signaling abnormal C_elegans_phenotype_ontology WBPhenotype:0001347 intestinal calcium signaling variant Any variation in the series of molecular signals in which an intestinal cell uses calcium ions to convert an extracellular signal into a response, compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the form or composition of a structure in the cell nucleus which contains the genetic material encoded as DNA and surrounded by histone proteins and other regulatory elements compared to control. In C. elegans the normal cell contains 5 pairs of 'autosomes' and one or two X chromosomes (Wormatlas). chromosome morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001348 chromosome morphology variant Variations in the form or composition of a structure in the cell nucleus which contains the genetic material encoded as DNA and surrounded by histone proteins and other regulatory elements compared to control. In C. elegans the normal cell contains 5 pairs of 'autosomes' and one or two X chromosomes (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the processes that incorporate phosphate groups to one or more amino acids within a protein, compared to control. protein phosphorylation abnormal C_elegans_phenotype_ontology WBPhenotype:0001349 protein phosphorylation variant Variations in the processes that incorporate phosphate groups to one or more amino acids within a protein, compared to control. GO:0006468 WB:WBPerson2021 Animals exhibit higher levels of protein phosphorylation compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001350 protein phosphorylation increased Animals exhibit higher levels of protein phosphorylation compared to that observed in control animals. WB:WBPerson2021 Animals exhibit decreased levels of protein phosphorylation compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001351 protein phosphorylation reduced Animals exhibit decreased levels of protein phosphorylation compared to that observed in control animals. WB:WBPerson2021 Variations in the chemical reactions and pathways of the endoplasmic reticulum compared to control. endoplasmic reticulum metabolism abnormal C_elegans_phenotype_ontology er metabolism abnormal WBPhenotype:0001352 endoplasmic reticulum metabolism variant Variations in the chemical reactions and pathways of the endoplasmic reticulum compared to control. WB:WBPerson2021 The coordinated movement during prophase of the two centrosomes and the two pronuclei towards the center of the one cell embryo is abolished. centration abnormal C_elegans_phenotype_ontology WBPhenotype:0001353 centration defective early emb The coordinated movement during prophase of the two centrosomes and the two pronuclei towards the center of the one cell embryo is abolished. WB:WBPaper00027230 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure, composition or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas). actin cytoskeleton filament morphology abnormal actin cytoskeleton filament morphology variant C_elegans_phenotype_ontology WBPhenotype:0001354 actin cytoskeleton filament morphology phenotype Animals exhibit variations in the form, structure, composition or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas). gonad morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001355 gonad morphology variant Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the form, structure or composition of the muscles of the adult male reproductive system compared to control. In C. elegans males, the M myoblast gives rise to a much larger set of specialized muscles, compared to hermaphrodites, which differentiate within the tail region (Wormatlas). male sex muscle morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001356 male sex muscle morphology variant Any variation in the form, structure or composition of the muscles of the adult male reproductive system compared to control. In C. elegans males, the M myoblast gives rise to a much larger set of specialized muscles, compared to hermaphrodites, which differentiate within the tail region (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male gametes compared to control (Wormatlas). male gonad morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001357 male gonad morphology variant Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male gametes compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Male animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in control animals. male nervous system morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001358 male nervous system morphology variant Male animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the structure and organization of the chamber in the male tail that extends from the termination of four canals (vas deferens, gut, and left and right spicule channels) to just before the cloaca, from that observed in control animals. proctodeum morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001359 proctodeum morphology variant Animals exhibit variations in the structure and organization of the chamber in the male tail that extends from the termination of four canals (vas deferens, gut, and left and right spicule channels) to just before the cloaca, from that observed in control animals. WB:WBPaper00027278 WB:WBPerson712 Hermaphrodites fail to produce any viable progeny via self-fertilization. However, such hermaphrodites can successfully reproduce if mated to control males. C_elegans_phenotype_ontology WBPhenotype:0001360 hermaphrodite self sterile Hermaphrodites fail to produce any viable progeny via self-fertilization. However, such hermaphrodites can successfully reproduce if mated to control males. WB:WBPaper00001075 WB:WBPerson2021 Any variation in the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells compared to control. chromosome condensation abnormal C_elegans_phenotype_ontology WBPhenotype:0001361 chromosome condensation variant Any variation in the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells compared to control. GO:0030261 WB:WBPerson2021 WB:WBPerson557 The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis in eukaryotic cells is abolished. C_elegans_phenotype_ontology WBPhenotype:0001362 chromosome condensation failure The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis in eukaryotic cells is abolished. GO:0030261 WB:WBPerson2021 WB:WBPerson557 The head contains cavities, possibly indicative of inappropriate cell death. C_elegans_phenotype_ontology head vacuole WBPhenotype:0001363 head cavity The head contains cavities, possibly indicative of inappropriate cell death. WB:cab Any variation in the form, structure or composition of the flattened structure extending laterally at the extreme tip of the adult male consisting of nine pairs of sensory rays that lie within a web-like cuticle compared to control. male fan morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001364 male fan morphology variant Any variation in the form, structure or composition of the flattened structure extending laterally at the extreme tip of the adult male consisting of nine pairs of sensory rays that lie within a web-like cuticle compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the process whose specific outcome is the progression of the male bursa over time, from its formation to the mature structure, compared to control. The male bursa consists of the lateral fan and rays (WormAtlas). male bursa development abnormal C_elegans_phenotype_ontology WBPhenotype:0001365 male bursa development variant Any variation in the process whose specific outcome is the progression of the male bursa over time, from its formation to the mature structure, compared to control. The male bursa consists of the lateral fan and rays (WormAtlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the process whose specific outcome is the progression of the male fan over time, from its formation to the mature structure, compared to control. male fan development abnormal C_elegans_phenotype_ontology WBPhenotype:0001366 male fan development variant Any variation in the process whose specific outcome is the progression of the male fan over time, from its formation to the mature structure, compared to control. WB:WBPerson2021 Any variation in the process whose specific outcome is the progression of the male proctodeum over time, from its formation to the mature structure, compared to control. The union of the vas deferens and the intestine give rise to the proctodeum which contains copulatory spicules. proctodeum development abnormal C_elegans_phenotype_ontology WBPhenotype:0001367 proctodeum development variant Any variation in the process whose specific outcome is the progression of the male proctodeum over time, from its formation to the mature structure, compared to control. The union of the vas deferens and the intestine give rise to the proctodeum which contains copulatory spicules. WB:WBPerson2021 Animals lack the somatic gonad structure that connects the distal gonad arm to the uterus. C_elegans_phenotype_ontology WBPhenotype:0001368 spermatheca absent Animals lack the somatic gonad structure that connects the distal gonad arm to the uterus. WB:WBPerson2021 WB:WBPerson557 Variations in the selective and non-covalent physical association between two or more proteins, or a protein and nucleic acid/macromolecular complex, compared to control. protein interaction abnormal C_elegans_phenotype_ontology WBPhenotype:0001369 protein interaction variant Variations in the selective and non-covalent physical association between two or more proteins, or a protein and nucleic acid/macromolecular complex, compared to control. GO:0005515 WB:WBPerson2021 Variations in the selective and non-covalent physical association between two or more proteins, compared to control. protein protein interaction abnormal C_elegans_phenotype_ontology WBPhenotype:0001370 protein protein interaction variant Variations in the selective and non-covalent physical association between two or more proteins, compared to control. WB:WBPerson2021 Variations in the selective and non-covalent physical association between a protein and a specific RNA sequence, compared to control. protein RNA interaction abnormal C_elegans_phenotype_ontology WBPhenotype:0001371 protein RNA interaction variant Variations in the selective and non-covalent physical association between a protein and a specific RNA sequence, compared to control. WB:WBPerson2021 Variations in the selective and non-covalent physical association between a protein and a specific DNA sequence, compared to control. protein DNA interaction abnormal C_elegans_phenotype_ontology WBPhenotype:0001372 protein DNA interaction variant Variations in the selective and non-covalent physical association between a protein and a specific DNA sequence, compared to control. WB:WBPerson2021 Animals lack a specific protein-RNA interaction observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001373 protein RNA interaction abolished Animals lack a specific protein-RNA interaction observed in control animals. WB:WBPerson2021 The shape and size of nuclei as well as the distribution of nucleoporins are strongly affected. pronuclear nuclear appearance abnormal C_elegans_phenotype_ontology Pna WBPhenotype:0001374 pronuclear nuclear appearance variant emb The shape and size of nuclei as well as the distribution of nucleoporins are strongly affected. WB:WBPaper00028895 WB:cab The expression of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism is reduced below the threshold of detection. C_elegans_phenotype_ontology WBPhenotype:0001375 transgene expression undetectable The expression of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism is reduced below the threshold of detection. WB:WBPerson557 The expression of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism is reduced below the threshold of detection in specific cells. C_elegans_phenotype_ontology WBPhenotype:0001376 transgene expression undetectable cell specific The expression of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism is reduced below the threshold of detection in specific cells. WB:WBPerson557 Variations in the generation of foci that mark crossover recombination events, compared to control. These foci mark the boundary of asymmetric synaptonemal complex disassembly. break induced focus formation abnormal C_elegans_phenotype_ontology WBPhenotype:0001377 break induced focus formation variant Variations in the generation of foci that mark crossover recombination events, compared to control. These foci mark the boundary of asymmetric synaptonemal complex disassembly. WB:WBPaper00032296 WB:WBPerson2021 WB:WBPerson557 Any variation in the cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle compared to control animals. mitotic chromosome segregation abnormal C_elegans_phenotype_ontology WBPhenotype:0001378 Possible XP. mitotic chromosome segregation variant Any variation in the cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle compared to control animals. GO:0000070 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals. organism toxic chemical response abnormal C_elegans_phenotype_ontology WBPhenotype:0001379 organism toxic chemical response variant Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals. WB:WBPerson557 Animals respond to anoxic (trace oxygen levels) stress after a shorter exposure time compared to control. C_elegans_phenotype_ontology WBPhenotype:0001380 anoxia hypersensitive Animals respond to anoxic (trace oxygen levels) stress after a shorter exposure time compared to control. WB:WBPerson2021 Animals fail to respond to trace amounts of oxygen that elicit a response in control animals. C_elegans_phenotype_ontology WBPhenotype:0001381 anoxia resistant Animals fail to respond to trace amounts of oxygen that elicit a response in control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications), compared to control. This includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). protein modification abnormal C_elegans_phenotype_ontology WBPhenotype:0001382 protein modification variant Variations in the covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications), compared to control. This includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). GO:0006464 WB:WBPerson2021 Variations in the processes that incorporate methyl groups to one or more amino acids within a protein, compared to control. protein methylation abnormal C_elegans_phenotype_ontology WBPhenotype:0001383 protein methylation variant Variations in the processes that incorporate methyl groups to one or more amino acids within a protein, compared to control. GO:0006479 WB:WBPerson2021 Animals exhibit a reduction in the production of new individuals that contain some portion of their genetic material inherited from that organism as a result of defective gametes. C_elegans_phenotype_ontology WBPhenotype:0001384 fertility reduced Animals exhibit a reduction in the production of new individuals that contain some portion of their genetic material inherited from that organism as a result of defective gametes. GO:0000003 WB:WBPerson2021 WB:WBPerson557 Relatively unspecialized germ cells prematurely acquire the specialized properties of mature oocytes. C_elegans_phenotype_ontology WBPhenotype:0001385 precocious oogenesis Relatively unspecialized germ cells prematurely acquire the specialized properties of mature oocytes. WB:WBPaper00001475 WB:WBPaper00028819 WB:WBPerson2021 Any perturbation that disrupts the fusion of male and female gametes (sperm and oocyte) in adult hermaphrodites during sexual reproduction. C_elegans_phenotype_ontology WBPhenotype:0001386 fertilization defective hermaphrodite Any perturbation that disrupts the fusion of male and female gametes (sperm and oocyte) in adult hermaphrodites during sexual reproduction. WB:WBPerson2021 Failure of male-derived sperm to fuse with an oocyte during sexual reproduction. C_elegans_phenotype_ontology WBPhenotype:0001387 fertilization defect male Failure of male-derived sperm to fuse with an oocyte during sexual reproduction. WB:WBPaper00033007 WB:WBPerson2021 Organisms respond to a lower dosage of gamma rays or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001388 organism hypersensitive gamma irradiation Organisms respond to a lower dosage of gamma rays or a shorter exposure compared to control animals. WB:WBPerson557 Cells fail to respond to the dosage of gamma irradiation that elicits a response in control animals. Alternatively, cells require longer exposure times to gamma irradiation to mimic the response observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001389 cell gamma ray resistant Cells fail to respond to the dosage of gamma irradiation that elicits a response in control animals. Alternatively, cells require longer exposure times to gamma irradiation to mimic the response observed in control animals. WB:WBPerson2021 WB:WBPerson557 Cells respond to a lower dosage of UV or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001390 cell UV hypersensitive Cells respond to a lower dosage of UV or a shorter exposure compared to control animals. WB:WBPerson557 Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, gamma irradiation, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001391 gamma ray induced apoptosis increased Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, gamma irradiation, compared to control. WB:WBPerson712 Cells of the animals cease during one of its replicative phases (G1, S, G2, M). C_elegans_phenotype_ontology WBPhenotype:0001392 cell cycle arrest Cells of the animals cease during one of its replicative phases (G1, S, G2, M). GO:0051726 WB:WBPerson557 WB:WBPerson712 Variations in the processes that reduce the internal pH of a cell (measured by the concentration of the hydrogen ion), compared to control. cell acidification abnormal C_elegans_phenotype_ontology WBPhenotype:0001393 cell acidification variant Variations in the processes that reduce the internal pH of a cell (measured by the concentration of the hydrogen ion), compared to control. GO:0045851 WB:WBPerson2021 Animals lack the capacity to reduce the internal pH of a cell. C_elegans_phenotype_ontology no pumping WBPhenotype:0001394 cell acidification defective Animals lack the capacity to reduce the internal pH of a cell. GO:0045851 WB:WBPerson2021 Vacuoles accumulate in the body. A vacuole is a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. C_elegans_phenotype_ontology WBPhenotype:0001395 body vacuole Vacuoles accumulate in the body. A vacuole is a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. GO:0005776 WB:WBPerson557 Animals completely lack any pharyngeal pumping motion. C_elegans_phenotype_ontology WBPhenotype:0001396 pumping absent Animals completely lack any pharyngeal pumping motion. WB:WBPaper00001894 WB:WBPerson2021 Animals exhibit an increase in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001397 necrotic cell death increased Animals exhibit an increase in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control. GO:0070265 WB:WBPerson712 Animals display variations in the structure, organization of components, or spatial pattern of any projection stemming from a neuronal cell, compared to that observed in control animals. neurite morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001398 neurite morphology variant Animals display variations in the structure, organization of components, or spatial pattern of any projection stemming from a neuronal cell, compared to that observed in control animals. GO:0043005 WB:WBPaper00028886 WB:WBPerson712 Any variation in the structure, form or composition of the semipermeable lipid bilayer that creates a boundary between the interior and exterior environment for cells, cellular organelles and tissues, within an organism compared to control. cell membrane morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001399 cell membrane morphology variant Any variation in the structure, form or composition of the semipermeable lipid bilayer that creates a boundary between the interior and exterior environment for cells, cellular organelles and tissues, within an organism compared to control. GO:0005886 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the measured expression of a protein compared to that observed in control animals. level of protein expression abnormal C_elegans_phenotype_ontology WBPhenotype:0001400 level of protein expression variant Animals exhibit variations in the measured expression of a protein compared to that observed in control animals. WB:WBPerson2021 The morphological appearance of mitochondria is varied compared to control animals. mitochondria morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001401 mitochondria morphology variant The morphological appearance of mitochondria is varied compared to control animals. WB:cab Mitochondria are interconnected by thin tubules of mitochondrial inner or outer membrane. connected mitochodria muscle connected mitochondria epithelial C_elegans_phenotype_ontology WBPhenotype:0001402 connected mitochondria Mitochondria are interconnected by thin tubules of mitochondrial inner or outer membrane. GO:0007006 WB:WBPaper00032231 WB:WBPerson712 Any variation in the placement of a protein, as detected by antibody staining, within in a cell or cellular compartment compared to control. antibody subcellular localization abnormal C_elegans_phenotype_ontology WBPhenotype:0001403 antibody subcellular localization variant Any variation in the placement of a protein, as detected by antibody staining, within in a cell or cellular compartment compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation that results in the detection of protein expression in cells/tissues through antibody staining, that is otherwise not observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001404 ectopic expression antibody Any variation that results in the detection of protein expression in cells/tissues through antibody staining, that is otherwise not observed in control animals. WB:WBPerson2021 WB:WBPerson557 Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding. protein aggregation abnormal C_elegans_phenotype_ontology WBPhenotype:0001405 protein aggregation variant Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding. WB:WBPaper00034765 WB:WBPerson2021 Variations that result in a decrease in protein expression in male animals compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001406 protein expression reduced male Variations that result in a decrease in protein expression in male animals compared to that observed in control animals. WB:WBPerson2021 Variations that result in a decrease in protein expression in specific cells compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001407 protein expression reduced cell specific Variations that result in a decrease in protein expression in specific cells compared to that observed in control animals. WB:WBPerson2021 Any variation in the cellular or subcellular distribution of a protein compared to that observed in control animals. pattern protein expression abnormal C_elegans_phenotype_ontology WBPhenotype:0001408 pattern protein expression variant Any variation in the cellular or subcellular distribution of a protein compared to that observed in control animals. WB:WBPerson2021 Any variation that results in the cellular expression of a protein in cells/tissues, that is otherwise not observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001409 protein expression ectopic Any variation that results in the cellular expression of a protein in cells/tissues, that is otherwise not observed in control animals. WB:WBPerson2021 Animals fail to express a given protein or class of proteins. C_elegans_phenotype_ontology WBPhenotype:0001410 protein expression absent Animals fail to express a given protein or class of proteins. WB:WBPerson2021 Animals exhibit an altered display of glycosylated proteins or lipids or altered access to glycosylated moieties along their surface from that observed in control animals of the same developmental stage. In C. elegans, variations in surface accessible glycosylated species are often revealed by altered lectin-binding from that observed in control animals. Srf cuticle carbohydrate surface abnormal C_elegans_phenotype_ontology ectopic lectin binding WBPhenotype:0001411 cuticle carbohydrate surface variant Animals exhibit an altered display of glycosylated proteins or lipids or altered access to glycosylated moieties along their surface from that observed in control animals of the same developmental stage. In C. elegans, variations in surface accessible glycosylated species are often revealed by altered lectin-binding from that observed in control animals. WB:WBPaper00001576 WB:WBPerson712 Animals exhibit variations in the organization of the longitudinal ridges on the cuticle along the length of the animal, from that observed for control animals of the same developmental stage. alae morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001412 alae morphology variant Animals exhibit variations in the organization of the longitudinal ridges on the cuticle along the length of the animal, from that observed for control animals of the same developmental stage. WB:WBPaper00000465 WB:WBPaper00031415 WB:WBPerson712 Animals do not exhibit tail-swelling in response to infection by a bacterial pathogen (such as Microbacterium nematophilum) compared to control. Bus C_elegans_phenotype_ontology WBPhenotype:0001413 bacterially unswollen Animals do not exhibit tail-swelling in response to infection by a bacterial pathogen (such as Microbacterium nematophilum) compared to control. WB:WBPaper00026735 WB:cab Males exhibit defects in the specific actions or reactions that are associated with reproduction. Cod C_elegans_phenotype_ontology WBPhenotype:0001414 male mating defective Males exhibit defects in the specific actions or reactions that are associated with reproduction. GO:0060179 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations that result in variations in the ability of or extent to which pathogens adhere to the surface of animals, compared to control. pathogen adherence abnormal C_elegans_phenotype_ontology WBPhenotype:0001415 pathogen adherence variant Animals exhibit variations that result in variations in the ability of or extent to which pathogens adhere to the surface of animals, compared to control. WB:WBPaper00026735 WB:WBPerson2987 WB:cab Pathogens are unable to adhere/colonize the surface of host animals. This defect is often associated with changes in cuticle surface properties of the host. C_elegans_phenotype_ontology WBPhenotype:0001416 pathogen adherence defect Pathogens are unable to adhere/colonize the surface of host animals. This defect is often associated with changes in cuticle surface properties of the host. WB:WBPaper00028877 WB:WBPerson2021 Any variation in the state or activity of an organism in response to extreme dryness or drought-like conditions, compared to control . organism desication response abnormal C_elegans_phenotype_ontology WBPhenotype:0001417 organism desiccation response variant Any variation in the state or activity of an organism in response to extreme dryness or drought-like conditions, compared to control . GO:0009819 WB:WBPerson2021 Animals respond to less severe drought-like conditions or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001418 organism hypersensitive desiccation Animals respond to less severe drought-like conditions or a shorter exposure compared to control animals. WB:WBPerson2021 Animals respond to emetine at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001419 emetine hypersensitive Animals respond to emetine at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals can move thorough a lawn of bacterially produced biofilm without accumulating an enormous amount of biofilm on its nose. When C. elegans is exposed to certain bacteria (e.g., Y. pestis), a biofilm accumulates on a worm's head. The presence of this biofilm inhibits feeding by the worm, and thereby prevents growth. Bah C_elegans_phenotype_ontology WBPhenotype:0001420 biofilm absent head Animals can move thorough a lawn of bacterially produced biofilm without accumulating an enormous amount of biofilm on its nose. When C. elegans is exposed to certain bacteria (e.g., Y. pestis), a biofilm accumulates on a worm's head. The presence of this biofilm inhibits feeding by the worm, and thereby prevents growth. WB:WBPaper00005238 WB:cab Animals exhibit variations in the directed movement of substances into, out of or mediated by the endosome, a membrane-bound organelle that trafficks material to different compartments of the cell or back to the plasma membrane for recycling compared to control. endocytic transport abnormal C_elegans_phenotype_ontology WBPhenotype:0001421 endocytic transport variant Animals exhibit variations in the directed movement of substances into, out of or mediated by the endosome, a membrane-bound organelle that trafficks material to different compartments of the cell or back to the plasma membrane for recycling compared to control. GO:0016197 WB:WBPaper00031894 WB:WBPerson712 Animals exhibit defects in the directed movement of substances into, out of or mediated by the endosome, a membrane-bound organelle that trafficks material to different compartments of the cell or back to the plasma membrane for recycling. C_elegans_phenotype_ontology WBPhenotype:0001422 endocytic transport defect Animals exhibit defects in the directed movement of substances into, out of or mediated by the endosome, a membrane-bound organelle that trafficks material to different compartments of the cell or back to the plasma membrane for recycling. GO:0016197 WB:WBPerson557 Animals exhibit variations in any physical or chemical process required for the coelomocyte to carry out its normal functions or activities, compared to control animals. coelomocyte physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001423 coelomocyte physiology variant Animals exhibit variations in any physical or chemical process required for the coelomocyte to carry out its normal functions or activities, compared to control animals. GO:0009987 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for the oocyte to carry out its normal functions or activities, compared to control animals. oocyte physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001424 oocyte physiology variant Animals exhibit variations in any physical or chemical process required for the oocyte to carry out its normal functions or activities, compared to control animals. GO:0009987 WB:WBPerson557 WB:WBPerson712 Animals exhibit defects in the cell-mediated uptake of external materials via receptor activity. Receptor-mediated endocytosis ensures specificity of transport and generally occurs via clathrin-coated pits and vesicles. In C. elegans, this is often judged by the lack of yolk uptake in oocytes. C_elegans_phenotype_ontology Rme WBPhenotype:0001425 Possible XP = GO:0006898. receptor mediated endocytosis defective Animals exhibit defects in the cell-mediated uptake of external materials via receptor activity. Receptor-mediated endocytosis ensures specificity of transport and generally occurs via clathrin-coated pits and vesicles. In C. elegans, this is often judged by the lack of yolk uptake in oocytes. GO:0006898 WB:WBPerson2021 WB:cab pmid:16042554 Fluid-phase endocytosis by coelomocytes is less frequent or efficient compared to control. C_elegans_phenotype_ontology Cup WBPhenotype:0001426 coelomocyte endocytosis defective Fluid-phase endocytosis by coelomocytes is less frequent or efficient compared to control. WB:cab pmid:16042554 Animals exhibit variations in the form, structure or composition of any cellular contents (excluding plasma membrane and nucleus), compared to control animals. cytoplasmic appearance abnormal C_elegans_phenotype_ontology WBPhenotype:0001427 cytoplasmic appearance variant Animals exhibit variations in the form, structure or composition of any cellular contents (excluding plasma membrane and nucleus), compared to control animals. WB:WBPerson2021 WB:WBPerson557 Vacuoles accumulate in the intestine. C_elegans_phenotype_ontology WBPhenotype:0001428 intestinal vacuole Vacuoles accumulate in the intestine. WB:WBPaper00004718 WB:WBPaper00031894 WB:WBPerson712 Animals accumulate an excess of vesicle-like structures in cells. C_elegans_phenotype_ontology WBPhenotype:0001429 granules cytoplasm Animals accumulate an excess of vesicle-like structures in cells. WB:cab pmid:17203072 Variations in the processes that are carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome, compared to control. lysosome organization biogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0001430 Possible XP. lysosome organization biogenesis variant Variations in the processes that are carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome, compared to control. GO:0007040 WB:WBPerson2021 WB:WBPerson557 Male tails fail to undergo tip retraction thereby forming a 'leptoderan' or 'pointed' adult tail. Lep male tail spike C_elegans_phenotype_ontology leptoderan tail WBPhenotype:0001431 pointed tail tip male Male tails fail to undergo tip retraction thereby forming a 'leptoderan' or 'pointed' adult tail. WB:WBPerson2021 WB:WBPerson557 Adult males exhibit a truncated tail, often without a fan or have well-developed fans but squarish, truncated back ends compared to control. In C. elegans this is due to precocious male tail tip retraction beginning in the early L3 stage (normally retraction begins in the L4 stage). Condition can be lethal if the function of the anus is affected. Ore C_elegans_phenotype_ontology WBPhenotype:0001432 over retracted male tail Adult males exhibit a truncated tail, often without a fan or have well-developed fans but squarish, truncated back ends compared to control. In C. elegans this is due to precocious male tail tip retraction beginning in the early L3 stage (normally retraction begins in the L4 stage). Condition can be lethal if the function of the anus is affected. WB:cab pmid:16806150 Two or more individual cells form a syncytium (a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane) via the fusion of the plasma membranes at an earlier stage of development compared to comparable cells in control animals. C_elegans_phenotype_ontology WBPhenotype:0001433 precocious cell fusion Two or more individual cells form a syncytium (a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane) via the fusion of the plasma membranes at an earlier stage of development compared to comparable cells in control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the directed movement of a worm in response to a specific chemical concentration gradient compared to control. Directed movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). chemotaxis abnormal C_elegans_phenotype_ontology Che WBPhenotype:0001434 chemotaxis variant Any variation in the directed movement of a worm in response to a specific chemical concentration gradient compared to control. Directed movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0006935 WB:cab Failure in directed movement in response to ammonium chloride compared to control. In C. elegans, NH4Cl is an attractant. NH4Cl has also subsequently been used to assay for Cl- attraction in C. elegans. C_elegans_phenotype_ontology chloride chemotaxis defective WBPhenotype:0001435 ammonium chloride chemotaxis defective Failure in directed movement in response to ammonium chloride compared to control. In C. elegans, NH4Cl is an attractant. NH4Cl has also subsequently been used to assay for Cl- attraction in C. elegans. WB:WBPaper00002087 WB:WBPaper00004609 WB:WBPaper00026812 chloride chemotaxis defective WB:WBPerson2021 Animals tend to initiate a response more often, compared to control, after nose-on collisions with an object. In C. elegans, animals initiate backwards movement in response to nose touch. C_elegans_phenotype_ontology WBPhenotype:0001436 nose touch hypersensitive Animals tend to initiate a response more often, compared to control, after nose-on collisions with an object. In C. elegans, animals initiate backwards movement in response to nose touch. WB:WBPaper00028963 WB:WBPerson557 Animals execute a response, via directed movement to octanol at a lower concentration or shorter exposure time compared to control. In C. elegans, animals avoid octanol. C_elegans_phenotype_ontology WBPhenotype:0001437 octanol chemotaxis hypersensitive Animals execute a response, via directed movement to octanol at a lower concentration or shorter exposure time compared to control. In C. elegans, animals avoid octanol. WB:WBPaper00028963 Animals fail to move towards attractive volatile organic molecules. In C. elegans, these compounds are sensed by the AWA and AWC neurons. C_elegans_phenotype_ontology WBPhenotype:0001438 odorant positive chemotaxis defective Animals fail to move towards attractive volatile organic molecules. In C. elegans, these compounds are sensed by the AWA and AWC neurons. WB:WBPerson2021 Animals fail to move towards attractive anions. C_elegans_phenotype_ontology WBPhenotype:0001439 anion positive chemotaxis defective Animals fail to move towards attractive anions. WB:WBPaper00002033 WB:WBPaper00028386 Animals fail to move towards attractive cations. C_elegans_phenotype_ontology WBPhenotype:0001440 cation positive chemotaxis defective Animals fail to move towards attractive cations. WB:WBPaper00004609 Animals fail to move towards attractive water-soluble chemicals. C_elegans_phenotype_ontology water soluble positive chemotaxis abnormal WBPhenotype:0001441 aqueous positive chemotaxis defective Animals fail to move towards attractive water-soluble chemicals. WB:WBPerson2021 Failure in directed movement in response to sodium acetate. In C. elegans, sodium acetate is an attractant. Sodium acetate has also subsequently been used to assay for Na+ attraction in C. elegans. C_elegans_phenotype_ontology sodium chemotaxis defective WBPhenotype:0001442 sodium acetate chemotaxis defective Failure in directed movement in response to sodium acetate. In C. elegans, sodium acetate is an attractant. Sodium acetate has also subsequently been used to assay for Na+ attraction in C. elegans. WB:WBPaper00000650 WB:WBPaper00004609 WB:WBPaper00006394 sodium chemotaxis defective WB:WBPerson2021 Animals exhibit variations in response to water-soluble chemicals, compared to control. aqueous chemosensory response abnormal C_elegans_phenotype_ontology water soluble chemosensory response abnormal WBPhenotype:0001443 aqueous chemosensory response variant Animals exhibit variations in response to water-soluble chemicals, compared to control. WB:cab Animals do not exhibit characteristic desensitization to a water-soluble chemo-attractive signal in a time-concentration dependent and reversible manner compared to control. aqueous adaptation abnormal C_elegans_phenotype_ontology gustatory plasticity abnormal water soluble adaptation abnormal WBPhenotype:0001444 aqueous adaptation defective Animals do not exhibit characteristic desensitization to a water-soluble chemo-attractive signal in a time-concentration dependent and reversible manner compared to control. WB:cab WB:cgc5150 Animals do not exhibit characteristic chemoattractive desensitization to sodium acetate in a time-concentration dependent and reversible manner compared to control. sodium acetate adaptation abnormal C_elegans_phenotype_ontology WBPhenotype:0001445 sodium acetate adaptation defective Animals do not exhibit characteristic chemoattractive desensitization to sodium acetate in a time-concentration dependent and reversible manner compared to control. WB:cab WB:cgc5150 Animals do not exhibit characteristic chemoattractive desensitization to sodium chloride in a time-concentration dependent and reversible manner compared to control. sodium chloride adaptation abnormal C_elegans_phenotype_ontology WBPhenotype:0001446 sodium chloride adaptation defective Animals do not exhibit characteristic chemoattractive desensitization to sodium chloride in a time-concentration dependent and reversible manner compared to control. WB:cab WB:cgc5150 Animals do not exhibit characteristic chemoattractive desensitization to ammonium chloride in a time-concentration dependent and reversible manner compared to control. ammonium chloride adaptation abnormal C_elegans_phenotype_ontology WBPhenotype:0001447 ammonium chloride adaptation defective Animals do not exhibit characteristic chemoattractive desensitization to ammonium chloride in a time-concentration dependent and reversible manner compared to control. WB:cab WB:cgc5150 Animals fail to move away from repellant volatile organic chemicals. C_elegans_phenotype_ontology volatile negative chemotaxis defective WBPhenotype:0001448 odorant negative chemotaxis defective Animals fail to move away from repellant volatile organic chemicals. WB:WBPerson2021 Animals fail to move away from repellent water soluble chemicals. C_elegans_phenotype_ontology water soluble chemotaxis defective WBPhenotype:0001449 aqueous negative chemotaxis defective Animals fail to move away from repellent water soluble chemicals. WB:WBPerson2021 Animals exhibit variations through directed movement, in response to repellant water soluble chemicals, compared to control. aqueous negative chemotaxis abnormal C_elegans_phenotype_ontology water soluble chemotaxis abnormal WBPhenotype:0001450 aqueous negative chemotaxis variant Animals exhibit variations through directed movement, in response to repellant water soluble chemicals, compared to control. WB:WBPaper00006481 Any variation in the directed movement of a worm in response to a specific concentration gradient of garlic compared to control. In C. elegans, garlic is typically a repellant. garlic chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001451 garlic chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of garlic compared to control. In C. elegans, garlic is typically a repellant. WB:WBPaper00002135 WB:WBPaper00006481 WB:WBPerson557 Any variation in the directed movement of a worm in response to a specific concentration gradient of octanol. In C. elegans, octanol is typically a repellant. octanol chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001452 octanol chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of octanol. In C. elegans, octanol is typically a repellant. WB:WBPerson557 Animals exhibit variations in their avoidance response to high concentrations of sodium chloride solution compared to control. high sodium chloride concentration osmotic avoidance abnormal C_elegans_phenotype_ontology WBPhenotype:0001453 high sodium chloride concentration osmotic avoidance variant Animals exhibit variations in their avoidance response to high concentrations of sodium chloride solution compared to control. WB:WBPerson2021 Any variation in the directed movement of a worm in response to a specific concentration gradient of the bitter tastant quinine, a water soluble molecule. In C. elegans, quinine is typically a repellant. quinine chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001454 quinine chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of the bitter tastant quinine, a water soluble molecule. In C. elegans, quinine is typically a repellant. WB:WBPaper00002135 WB:WBPaper00027118 WB:WBPaper00035961 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations through directed movement, in response to repellant volatile organic chemicals, compared to control. odorant negative chemotaxis abnormal C_elegans_phenotype_ontology volatile negative chemotaxis abnormal WBPhenotype:0001455 odorant negative chemotaxis variant Animals exhibit variations through directed movement, in response to repellant volatile organic chemicals, compared to control. WB:WBPaper00001786 Any variation in the directed movement of a worm in response to a specific concentration gradient of nonanone. In C. elegans, nonanone is typically a repellant. nonanone chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001456 nonanone chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of nonanone. In C. elegans, nonanone is typically a repellant. WB:WBPerson2021 WB:WBPerson557 Any variation in the directed movement of a worm in response to a specific concentration gradient of bromide. In C. elegans, bromide is typically an attractant. bromide chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001457 bromide chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of bromide. In C. elegans, bromide is typically an attractant. WB:WBPaper00000387 WB:WBPerson557 Any variation in the directed movement of a worm in response to a specific concentration gradient of chloride. chloride chemotaxis abnormal C_elegans_phenotype_ontology ammonium chloride chemotaxis abnormal WBPhenotype:0001458 chloride chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of chloride. WB:WBPaper00000387 ammonium chloride chemotaxis abnormal WB:WBPerson2021 Any variation in the directed movement of a worm in response to a specific concentration gradient of iodide. iodide chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001459 iodide chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of iodide. WB:WBPaper00000387 Any variation in the directed movement of a worm in response to a specific concentration gradient of ammonium chloride. In C. elegans, at specific concentrations, ammonium chloride is an attractant. NH4Cl has also been used to assay for Cl- attraction. ammonium chloride chemotaxis abnormal C_elegans_phenotype_ontology chloride chemotaxis abnormal WBPhenotype:0001460 ammonium chloride chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of ammonium chloride. In C. elegans, at specific concentrations, ammonium chloride is an attractant. NH4Cl has also been used to assay for Cl- attraction. WB:WBPaper00000387 WB:WBPaper00004609 WB:WBPaper00026812 chloride chemotaxis abnormal WB:WBPerson2021 Any variation in the directed movement of a worm in response to a specific concentration gradient of sodium acetate. In C. elegans, at specific concentrations, sodium acetate is an attractant. Sodium acetate has also been used to assay for Na+ attraction. sodium acetate chemotaxis abnormal C_elegans_phenotype_ontology sodium chemotaxis abnormal WBPhenotype:0001461 sodium acetate chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of sodium acetate. In C. elegans, at specific concentrations, sodium acetate is an attractant. Sodium acetate has also been used to assay for Na+ attraction. WB:WBPaper00000387 WB:WBPaper00000650 WB:WBPaper00004609) sodium chemotaxis abnormal WB:WBPerson2021 Any variation in the directed movement of a worm in response to a specific concentration gradient of sodium chloride. In C. elegans, at specific concentrations, sodium chloride is an attractant. sodium chloride chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001462 sodium chloride chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of sodium chloride. In C. elegans, at specific concentrations, sodium chloride is an attractant. WB:WBPaper00000387 Any variation in the directed movement of a worm in response to a specific concentration gradient of cAMP. cAMP chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001463 cAMP chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of cAMP. GO:0043327 WB:WBPaper00000387 Any variation in the directed movement of a worm in response to a specific concentration gradient of cGMP. cGMP chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001464 cGMP chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of cGMP. WB:WBPaper00000387 Any variation in the directed movement of a worm in response to a specific concentration gradient of acetone. In C. elegans, at specific concentrations, acetone is an attractant. acetone chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001465 acetone chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of acetone. In C. elegans, at specific concentrations, acetone is an attractant. WB:WBPerson2021 WB:WBPerson557 Any variation in the directed movement of an animal in response to a volatile chemical stimulus that is usually received and processed by the AWA sensory neuron in control animals. AWA odorant chemotaxis abnormal C_elegans_phenotype_ontology AWA volatile chemotaxis abnormal WBPhenotype:0001466 AWA odorant chemotaxis variant Any variation in the directed movement of an animal in response to a volatile chemical stimulus that is usually received and processed by the AWA sensory neuron in control animals. WB:WBPerson2021 Any variation in the directed movement of an animal in response to a volatile chemical stimulus that is usually received and processed by the AWC sensory neuron in control animals. AWC odorant chemotaxis abnormal C_elegans_phenotype_ontology AWC volatile chemotaxis abnormal WBPhenotype:0001467 AWC odorant chemotaxis variant Any variation in the directed movement of an animal in response to a volatile chemical stimulus that is usually received and processed by the AWC sensory neuron in control animals. WB:WBPerson2021 Any variation in the directed movement of a worm in response to a specific concentration gradient of benzaldehyde. In C. elegans, at specific concentrations, benzaldehyde is an attractant. benzaldehyde chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001468 benzaldehyde chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of benzaldehyde. In C. elegans, at specific concentrations, benzaldehyde is an attractant. WB:WBPerson2021 WB:WBPerson557 Any variation in the directed movement of a worm in response to a specific concentration gradient of butanone. In C. elegans, at specific concentrations, butanone is an attractant. butanone chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001469 butanone chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of butanone. In C. elegans, at specific concentrations, butanone is an attractant. WB:WBPerson2021 WB:WBPerson557 Any variation in the directed movement of a worm in response to a specific concentration gradient of diacetyl. In C. elegans, at specific concentrations, diacetyl is an attractant. diacetyl chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001470 diacetyl chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of diacetyl. In C. elegans, at specific concentrations, diacetyl is an attractant. WB:WBPerson2021 WB:WBPerson557 Any variation in the directed movement of a worm in response to a specific concentration gradient of hexanol. In C. elegans, at specific concentrations, hexanol is an attractant. hexanol chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001471 hexanol chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of hexanol. In C. elegans, at specific concentrations, hexanol is an attractant. WB:WBPerson2021 WB:WBPerson557 Any variation in the directed movement of a worm in response to a specific concentration gradient of isoamyl alcohol. In C. elegans, at specific concentrations, isoamyl alcohol is an attractant. isoamyl alcohol chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001472 isoamyl alcohol chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of isoamyl alcohol. In C. elegans, at specific concentrations, isoamyl alcohol is an attractant. WB:WBPerson2021 WB:WBPerson557 Any variation in the directed movement of a worm in response to a specific concentration gradient of pentanol. In C. elegans, at specific concentrations, pentanol is an attractant. pentanol chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001473 pentanol chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of pentanol. In C. elegans, at specific concentrations, pentanol is an attractant. WB:WBPerson2021 WB:WBPerson557 Any variation in the directed movement of a worm in response to a specific concentration gradient of pyrazine. In C. elegans, at specific concentrations, pyrazine is an attractant. pyrazine chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001474 pyrazine chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of pyrazine. In C. elegans, at specific concentrations, pyrazine is an attractant. WB:WBPerson2021 WB:WBPerson557 Any variation in the directed movement of a worm in response to a specific concentration gradient of trimethylthiazole. In C. elegans, at specific concentrations, trimethylthiazole is an attractant. trimethylthiazole chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001475 trimethylthiazole chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of trimethylthiazole. In C. elegans, at specific concentrations, trimethylthiazole is an attractant. WB:WBPerson2021 WB:WBPerson557 Any variation in the defecation motor program that involves the contraction of the anterior body wall muscles compared to control. anterior body contraction abnormal C_elegans_phenotype_ontology WBPhenotype:0001476 anterior body contraction variant Any variation in the defecation motor program that involves the contraction of the anterior body wall muscles compared to control. WB:WBPaper00001937 WB:WBPerson2021 WB:WBPerson557 Any variation in the directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons, compared to control. anterograde transport abnormal C_elegans_phenotype_ontology WBPhenotype:0001477 anterograde transport variant Any variation in the directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons, compared to control. GO:0008089 WB:WBPerson2021 WB:WBPerson557 Any variation in the elongation of embryonic epidermal cells compared to control. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm. body elongation abnormal C_elegans_phenotype_ontology WBPhenotype:0001478 body elongation variant Any variation in the elongation of embryonic epidermal cells compared to control. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in any of a series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal that induces dauer formation in control animals. dauer pheromone sensation abnormal C_elegans_phenotype_ontology WBPhenotype:0001479 dauer pheromone sensation variant Animals exhibit variations in any of a series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal that induces dauer formation in control animals. GO:0043695 WB:WBPerson2021 WB:WBPerson557 Variations in the rhythmic relaxations of the a highly specialized cuticle region of the pharynx inside the lumen of the second bulb, compared to control (Wormatlas). grinder relaxation abnormal C_elegans_phenotype_ontology WBPhenotype:0001480 grinder relaxation variant Variations in the rhythmic relaxations of the a highly specialized cuticle region of the pharynx inside the lumen of the second bulb, compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The number of body thrashes within an aqueous environment in a given period of time is increased, compared with control worms. C_elegans_phenotype_ontology WBPhenotype:0001481 thrashing increased The number of body thrashes within an aqueous environment in a given period of time is increased, compared with control worms. WB:WBPerson2021 WB:WBPerson557 Animals exhibit a reduction in the frequency of oscillations between adjacent body segments from that observed for control animals. WBPhenotype:0002330 bending frequency reduced frequency of sinusoidal movement reduced temporal frequency of sinusoidal movement decreased C_elegans_phenotype_ontology WBPhenotype:0001482 frequency body bend reduced Animals exhibit a reduction in the frequency of oscillations between adjacent body segments from that observed for control animals. WB:WBPaper00024949 WB:WBPerson557 WB:WBPerson712 The eggs being deposited by adults are of a later developmental stage, compared to control. In C. elegans, this is likely to be a consequence of delayed active egg-laying periods. C_elegans_phenotype_ontology WBPhenotype:0001483 late stage egg laid The eggs being deposited by adults are of a later developmental stage, compared to control. In C. elegans, this is likely to be a consequence of delayed active egg-laying periods. WB:WBPaper00004310 WB:WBPerson2021 Animals fail to execute directed movement in response to ammonium acetate. In C. elegans, ammonium acetate is an attractant. C_elegans_phenotype_ontology WBPhenotype:0001484 ammonium acetate chemotaxis defective Animals fail to execute directed movement in response to ammonium acetate. In C. elegans, ammonium acetate is an attractant. WB:WBPaper00004136 Animals exhibit variations in their response to the presence of unfolded proteins in the endoplasmic reticulum (ER) or to other ER-related stressors compared to control. ER stress response abnormal endoplasmic reticulum stress response abnormal C_elegans_phenotype_ontology WBPhenotype:0001485 ER stress response variant Animals exhibit variations in their response to the presence of unfolded proteins in the endoplasmic reticulum (ER) or to other ER-related stressors compared to control. GO:0030968 Animals accumulate unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria. C_elegans_phenotype_ontology WBPhenotype:0001486 unfolded protein accumulation Animals accumulate unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria. WB:WBPerson557 Animals exhibit variations in the development of the male elongated sclerotized structures covered by a hardened layer of cuticle in the tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) compared to control. male spicule development abnormal C_elegans_phenotype_ontology WBPhenotype:0001487 male spicule development variant Animals exhibit variations in the development of the male elongated sclerotized structures covered by a hardened layer of cuticle in the tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) compared to control. WB:WBPerson363 WB:cab Animals exhibit variations in the development of the sclerotic cuticle that forms the roof of the proctodeum (gubernaculum) compared to control. gubernaculum development abnormal C_elegans_phenotype_ontology WBPhenotype:0001488 gubernaculum development variant Animals exhibit variations in the development of the sclerotic cuticle that forms the roof of the proctodeum (gubernaculum) compared to control. WB:WBPerson363 WB:cab Animals exhibit variations in the structure or composition of the sclerotic cuticle that forms the roof of the proctodeum, from that observed in control animals. gubernaculum morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001489 gubernaculum morphology variant Animals exhibit variations in the structure or composition of the sclerotic cuticle that forms the roof of the proctodeum, from that observed in control animals. WB:WBPaper00027278 WB:WBPerson363 WB:WBPerson712 WB:cab OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0001490 obsolete posterior region morphology abnormal true OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0001491 obsolete anterior region morphology abnormal true Animals lack a properly developed posterior region compared to control. In C. elegans, mutants exhibit a severely deformed posterior region with a variable knob-like shape; accompanied by arrest at about the time of hatching with fairly normal pharyngeal and anterior development. Most mutants arrest as L1 larvae, and 5% do not hatch. Nob C_elegans_phenotype_ontology WBPhenotype:0001492 no back end Animals lack a properly developed posterior region compared to control. In C. elegans, mutants exhibit a severely deformed posterior region with a variable knob-like shape; accompanied by arrest at about the time of hatching with fairly normal pharyngeal and anterior development. Most mutants arrest as L1 larvae, and 5% do not hatch. WB:cab WB:cgc4499 VPCs (vulval precursor cells) divide at an earlier stage of development compared to control animals; in C. elegans, VPCs divide in the mid-L3 stage to generate the 22 cells that comprise the vulva. C_elegans_phenotype_ontology WBPhenotype:0001493 VPC cell division precocious VPCs (vulval precursor cells) divide at an earlier stage of development compared to control animals; in C. elegans, VPCs divide in the mid-L3 stage to generate the 22 cells that comprise the vulva. WB:cab pmid:16300753 DTCs migrate at an earlier stage of development, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001494 distal tip cell migration precocious DTCs migrate at an earlier stage of development, compared to control. WB:cab pmid:16300753 Cells divide at an earlier stage of development compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001495 cell division precocious Cells divide at an earlier stage of development compared to control animals. WB:cab Cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase, compared to control. Metaphase is the second stage of chromosome segregation in the cell cycle where chromosomes become aligned on the equatorial plate of the cell and anaphase is the stage where sister chromatids (or homologous chromosomes) separate and migrate towards the poles of the spindle. WBPhenotype:0001214 metaphase to anaphase transition fails C_elegans_phenotype_ontology Mat WBPhenotype:0001496 metaphase to anaphase transition defect Cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase, compared to control. Metaphase is the second stage of chromosome segregation in the cell cycle where chromosomes become aligned on the equatorial plate of the cell and anaphase is the stage where sister chromatids (or homologous chromosomes) separate and migrate towards the poles of the spindle. GO:0007091 WB:WBPerson712 Cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase during mitosis, compared to control. Metaphase is the second stage of chromosome segregation in the cell cycle where chromosomes become aligned on the equatorial plate of the cell and anaphase is the stage where sister chromatids separate and migrate towards the poles of the spindle. C_elegans_phenotype_ontology WBPhenotype:0001497 mitotic metaphase to anaphase transition defect Cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase during mitosis, compared to control. Metaphase is the second stage of chromosome segregation in the cell cycle where chromosomes become aligned on the equatorial plate of the cell and anaphase is the stage where sister chromatids separate and migrate towards the poles of the spindle. GO:0007091 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for the pseudopod of the sperm to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. sperm pseudopod physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001498 sperm pseudopod physiology variant Animals exhibit variations in any physical or chemical process required for the pseudopod of the sperm to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals. WB:WBPerson557 Variations in the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle, compared to control. meiotic chromosome segregation abnormal C_elegans_phenotype_ontology WBPhenotype:0001499 Possible XP. meiotic chromosome segregation variant Variations in the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle, compared to control. GO:0045132 WB:WBPerson2021 WB:WBPerson557 Any variation in the directed movement of a worm in response to a specific concentration gradient of pentanedione. pentanedione chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0001500 pentanedione chemotaxis variant Any variation in the directed movement of a worm in response to a specific concentration gradient of pentanedione. WB:cab WB:cgc2931 Animals fail to discriminate between distinct odorants. odorant discrimination abnormal C_elegans_phenotype_ontology WBPhenotype:0001501 odorant discrimination defective Animals fail to discriminate between distinct odorants. WB:cab Animals fail to respond to the concentration of a specific chemical that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001502 chemical resistant Animals fail to respond to the concentration of a specific chemical that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Any variation in the mechanisms used to ensure that axons in the ventral nerve cord maintain their correct positioning after termination of axonal outgrowth and target recognition compared to control. ventral nerve cord maintenance abnormal C_elegans_phenotype_ontology WBPhenotype:0001503 ventral nerve cord maintenance variant Any variation in the mechanisms used to ensure that axons in the ventral nerve cord maintain their correct positioning after termination of axonal outgrowth and target recognition compared to control. WB:WBPaper00005064 WB:WBPerson557 Sterility caused by aberrant maternal components required for normal postembryonic development and/or function of the germ line. Mes C_elegans_phenotype_ontology WBPhenotype:0001504 maternal effect sterile Sterility caused by aberrant maternal components required for normal postembryonic development and/or function of the germ line. WB:WBPaper00001477 Any variation in the processes that govern spontaneous backward locomotion compared to control. spontaneous reversal abnormal C_elegans_phenotype_ontology WBPhenotype:0001505 spontaneous reversal variant Any variation in the processes that govern spontaneous backward locomotion compared to control. WB:WBPaper00001311 WB:WBPerson557 Any variation in the processes that govern the rate at which spontaneous backward locomotion is initiated compared to control. spontaneous reversal rate abnormal C_elegans_phenotype_ontology WBPhenotype:0001506 spontaneous reversal rate variant Any variation in the processes that govern the rate at which spontaneous backward locomotion is initiated compared to control. WB:WBPaper00001311 WB:WBPaper00026650 WB:WBPerson557 Animals fail to be affected by toxins produced by Bacillus thuringiensis (Bt toxins) in the same manner as control animals. C_elegans_phenotype_ontology WBPhenotype:0001507 Bacillus thuringiensis toxin resistant Animals fail to be affected by toxins produced by Bacillus thuringiensis (Bt toxins) in the same manner as control animals. GO:0009410 WB:WBPaper00004264 WB:WBPaper00004776 WB:WBPerson557 Any perturbation that disrupts the fusion between the anchor cell and the surrounding utse syncytium. Such variations result in the loss of uterine-vulval connectivity and continuity. anchor cell fusion abnormal C_elegans_phenotype_ontology WBPhenotype:0001508 anchor cell fusion defective Any perturbation that disrupts the fusion between the anchor cell and the surrounding utse syncytium. Such variations result in the loss of uterine-vulval connectivity and continuity. WB:WBPaper00029363 WB:WBPerson2021 Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are absent. WBPhenotype:0000407 ray loss C_elegans_phenotype_ontology WBPhenotype:0001509 rays missing Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are absent. WB:WBPerson2021 WB:WBPerson557 Any variation in the processes that govern acquisition of neuronal cell fates compared to control. neuronal cell fate specification abnormal C_elegans_phenotype_ontology WBPhenotype:0001510 neuronal cell fate specification variant Any variation in the processes that govern acquisition of neuronal cell fates compared to control. WB:WBPerson2021 Variations in the stereotypical migration pattern of the linker cell in a developing male compared to control. linker cell migration abnormal C_elegans_phenotype_ontology WBPhenotype:0001511 linker cell migration variant Variations in the stereotypical migration pattern of the linker cell in a developing male compared to control. WB:WBPaper00028966 WB:WBPerson2021 Bilaterally symmetric cell fail to acquire specific left-right asymmetric properties such as L/R specific cell position, cell death or gene expression. Lsy C_elegans_phenotype_ontology WBPhenotype:0001512 loss of left right asymmetry Bilaterally symmetric cell fail to acquire specific left-right asymmetric properties such as L/R specific cell position, cell death or gene expression. WB:WBPaper00037739 WB:WBPerson2021 Variations in the process of secretion of a class of membrane-bound vesicles found inside neurons, gland cells, and some epithelial cells in which the central core appears darkly stained when viewed in thin section by electron microscopy, compared to control. Exocytosis occurs via the fusion of the vesicle with the plasma membrane of a cell (Wormatlas). dense core vesicle exocytosis abnormal C_elegans_phenotype_ontology WBPhenotype:0001513 dense core vesicle exocytosis variant Variations in the process of secretion of a class of membrane-bound vesicles found inside neurons, gland cells, and some epithelial cells in which the central core appears darkly stained when viewed in thin section by electron microscopy, compared to control. Exocytosis occurs via the fusion of the vesicle with the plasma membrane of a cell (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the uptake of a small membrane-bound organelle, filled with neurotransmitter(s) and/or neuropeptides, by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle compared to control(Wormatlas). synaptic vesicle endocytosis abnormal C_elegans_phenotype_ontology WBPhenotype:0001514 synaptic vesicle endocytosis variant Variations in the uptake of a small membrane-bound organelle, filled with neurotransmitter(s) and/or neuropeptides, by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle compared to control(Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the quantity or patterning of electron-dense columnar structures that join the basal and cortical cuticle layers, from that observed in control animals. struts abnormal C_elegans_phenotype_ontology WBPhenotype:0001515 struts variant Animals exhibit variations in the quantity or patterning of electron-dense columnar structures that join the basal and cortical cuticle layers, from that observed in control animals. WB:WBPaper00000465 WB:WBPerson712 Animals exhibit a helically twisted cuticle. In practice the degree of twisting is measured as the number of helical twists the alae make about anterior/posterior axis of the animal. cuticle helicity abnormal C_elegans_phenotype_ontology WBPhenotype:0001516 helical cuticle Animals exhibit a helically twisted cuticle. In practice the degree of twisting is measured as the number of helical twists the alae make about anterior/posterior axis of the animal. WB:WBPaper00000465 WB:WBPerson712 Animals exhibit variations in the circumferential pattern of ridges in the outer cortical layer of the cuticle, compared to that observed in control animals of the same developmental stage. annulae morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001517 annulae morphology variant Animals exhibit variations in the circumferential pattern of ridges in the outer cortical layer of the cuticle, compared to that observed in control animals of the same developmental stage. WB:WBPaper00000465 WB:WBPaper00031415 WB:WBPerson712 Any variation in the levels and/or localization of biogenic amines compared to control animals. FIF biogenic amine physiology abnormal C_elegans_phenotype_ontology Formaldehyde induced fluorescence abnormal WBPhenotype:0001518 biogenic amine physiology variant Any variation in the levels and/or localization of biogenic amines compared to control animals. WB:WBPaper00000365 Any variation in the orderly movement of cells along the posterior axis of the animal (abolished, misdirected or incomplete) compared to control. abnormal posterior cell migration C_elegans_phenotype_ontology WBPhenotype:0001519 posterior cell migration variant Any variation in the orderly movement of cells along the posterior axis of the animal (abolished, misdirected or incomplete) compared to control. WB:WBPerson2021 Any variation in the orderly movement of neurons along the posterior axis of the animal(abolished, misdirected or incomplete) compared to control. abnormal posterior neuron migration C_elegans_phenotype_ontology WBPhenotype:0001520 posterior neuron migration variant Any variation in the orderly movement of neurons along the posterior axis of the animal(abolished, misdirected or incomplete) compared to control. WB:WBPerson2021 Embryos retract after the embryonic elongation process. C_elegans_phenotype_ontology WBPhenotype:0001521 body elongation retracted Embryos retract after the embryonic elongation process. WB:WBPerson557 The elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) constitutively extend into the external environment through the cloacal opening. In C. elegans males there are two copulatory spicules. C_elegans_phenotype_ontology WBPhenotype:0001522 spicules protrude The elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) constitutively extend into the external environment through the cloacal opening. In C. elegans males there are two copulatory spicules. WB:WBPerson2021 WB:WBPerson557 Any variation in the makeup, density or area of the ECM compared to control. extracellular matrix abnormal C_elegans_phenotype_ontology WBPhenotype:0001523 extracellular matrix variant Any variation in the makeup, density or area of the ECM compared to control. WB:WBPerson712 Exhibition of quiescent behavior under inappropriate conditions and improper recovery from quiescent state. Quiescent behavior is normally coupled with lethargus. quiescence abnormal C_elegans_phenotype_ontology narcoleptic WBPhenotype:0001524 quiescence variant Exhibition of quiescent behavior under inappropriate conditions and improper recovery from quiescent state. Quiescent behavior is normally coupled with lethargus. WB:WBPerson2021 Animals exhibit variations in the structure or organization of the posterior region of the pharynx compared to control. terminal bulb morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001525 terminal bulb morphology variant Animals exhibit variations in the structure or organization of the posterior region of the pharynx compared to control. WB:WBPerson2021 Animals exhibit variations in the structure or organization of any one of the specialized sensory receptor cells of the nervous system that compared to control animals. In C. elegans, these specialized cells are characterized as having axoneme containing dendritic projections emanating from their cell body. ciliated neuron morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001526 WBbt:0006816. ciliated neuron morphology variant Animals exhibit variations in the structure or organization of any one of the specialized sensory receptor cells of the nervous system that compared to control animals. In C. elegans, these specialized cells are characterized as having axoneme containing dendritic projections emanating from their cell body. WB:WBPaper00000503 WB:WBPaper00029016 WB:WBPerson712 Animals exhibit variations in the quantity, structure or organization of any component of any specialized chemosensory organs located on the head or along the tail, compared to that observed in control animals. amphid phasmid sensillum morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001527 WBbt:0005391. amphid phasmid sensillum morphology variant Animals exhibit variations in the quantity, structure or organization of any component of any specialized chemosensory organs located on the head or along the tail, compared to that observed in control animals. WB:WBPerson712 Animals exhibit variations in the quantity, structure or organization of any component of the sensillum channel including the sheath and or socket cells, their junctions with each other, channel neurons or surrounding epithelia compared to control. sensillum accessory cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001528 sensillum accessory cell morphology variant Animals exhibit variations in the quantity, structure or organization of any component of the sensillum channel including the sheath and or socket cells, their junctions with each other, channel neurons or surrounding epithelia compared to control. WB:WBPaper00000932 WB:WBPerson712 OBSOLETE: Any variation in the form, structure or composition of an interfacial epithelial cell which forms a specialized environment surrounding the ciliated sensory ending(s) of one or more neurons and is often accompanied by a more distal socket cell compared to control (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0001529 obsolete sensilium sheath cell variant true OBSOLETE: Any variation in the form, structure or composition of an interfacial epithelial cell which forms a specialized environment surrounding the ciliated sensory ending(s) of one or more neurons and is often accompanied by a more distal socket cell compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the quantity, structure or organization of any component of a specialized sensory organ in the head that contains a CEP receptor neuron, compared to control. In C. elegans, cells in these organs are refractory to FITC dye uptake. cephalic sensillum morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001530 WBbt:0006920. cephalic sensillum morphology variant Animals exhibit variations in the quantity, structure or organization of any component of a specialized sensory organ in the head that contains a CEP receptor neuron, compared to control. In C. elegans, cells in these organs are refractory to FITC dye uptake. WB:WBPaper00000214 WB:WBPaper00000503 WB:WBPaper00000932 WB:WBPerson712 Animals exhibit variations in the quantity, structure or organization of the sensilla of the mouth compared to control. In C. elegans, these sensillum are arranged in two (inner and outer) concentric rings around the mouth. labial sensillum morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001531 labial sensillum morphology variant Animals exhibit variations in the quantity, structure or organization of the sensilla of the mouth compared to control. In C. elegans, these sensillum are arranged in two (inner and outer) concentric rings around the mouth. WB:WBPaper00000214 WB:WBPaper00000938 WB:WBPerson712 Animals exhibit variations in the quantity, structure or organization of the components of the inner labial ring compared to control. In C. elegans, the ring is composed of six sensilla, which include associated neurons IL1 & IL2. inner labial morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001532 inner labial morphology variant Animals exhibit variations in the quantity, structure or organization of the components of the inner labial ring compared to control. In C. elegans, the ring is composed of six sensilla, which include associated neurons IL1 & IL2. WB:WBPaper00000938 WB:WBPerson712 Animals exhibit variations in the quantity, structure or organization of the components of the outer labial ring compared to control. In C. elegans, this ring consists of four sensilla (OLQ) or the two additional lateral sensilla (OLL), which are part of the labial sensillum. outer labial morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001533 outer labial morphology variant Animals exhibit variations in the quantity, structure or organization of the components of the outer labial ring compared to control. In C. elegans, this ring consists of four sensilla (OLQ) or the two additional lateral sensilla (OLL), which are part of the labial sensillum. WB:WBPaper00000938 WB:WBPerson712 Any variation in makeup, density or area of the ECM lending structure to neurons compared to control animals. In C. elegans, the neuronal ECM is sometimes referred to as a mantle. neuronal ECM abnormal C_elegans_phenotype_ontology WBPhenotype:0001534 neuronal ECM variant Any variation in makeup, density or area of the ECM lending structure to neurons compared to control animals. In C. elegans, the neuronal ECM is sometimes referred to as a mantle. WB:WBPaper00000502 WB:WBPerson712 Animals exhibit variations in the quantity, structure or organization of the components of the sensilla situated laterally in the anterior (ADE) or the posterior (PDE) of the animal compared to control. In C. elegans, each of the 4 deirid sensilla (2ADE, 2 PDE) contains a pair of neurons with ciliated dendritic processes that lie in a channel formed by a socket cell and invaginated sheath cell. The cilia of the deirids terminate in the subcuticle and are not exposed to the outside; however occasionally take up FITC. deirid sensillum morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001535 deirid sensillum morphology variant Animals exhibit variations in the quantity, structure or organization of the components of the sensilla situated laterally in the anterior (ADE) or the posterior (PDE) of the animal compared to control. In C. elegans, each of the 4 deirid sensilla (2ADE, 2 PDE) contains a pair of neurons with ciliated dendritic processes that lie in a channel formed by a socket cell and invaginated sheath cell. The cilia of the deirids terminate in the subcuticle and are not exposed to the outside; however occasionally take up FITC. WB:WBPaper00000938 WB:WBPaper00029016 WB:WBPerson712 Embryos exhibit variations in the patterning of differentiated cell types, compared to control. embryonic cell patterning abnormal C_elegans_phenotype_ontology WBPhenotype:0001536 embryonic cell patterning variant Embryos exhibit variations in the patterning of differentiated cell types, compared to control. WB:WBPerson557 Any variation in the ability of cells to monitor the quality of their mRNAs and degrade any transcripts that are poorly or incompletely translated compared to control. mRNA turnover abnormal C_elegans_phenotype_ontology WBPhenotype:0001537 mRNA surveillance variant Any variation in the ability of cells to monitor the quality of their mRNAs and degrade any transcripts that are poorly or incompletely translated compared to control. WB:WBPaper00004926 Defects in the cellular machinery that targets aberrant mRNAs species (nonsense codons, splice errors, altered untranslated regions etc.) for degradation. In C. elegans, mutations in such loci often act as allele-specific non gene-specific recessive suppressors of certain allele phenotypes and cause abnormal morphogenesis of male and hermaphrodite genitalia. Smg C_elegans_phenotype_ontology WBPhenotype:0001538 mRNA surveillance defective Defects in the cellular machinery that targets aberrant mRNAs species (nonsense codons, splice errors, altered untranslated regions etc.) for degradation. In C. elegans, mutations in such loci often act as allele-specific non gene-specific recessive suppressors of certain allele phenotypes and cause abnormal morphogenesis of male and hermaphrodite genitalia. WB:WBPaper00001192 WB:WBPaper00004926 Animals exhibit variations in the entry into the dauer stage when exposed to conditions that induce dauer formation in control animals. dauer induction abnormal C_elegans_phenotype_ontology WBPhenotype:0001539 dauer induction variant Animals exhibit variations in the entry into the dauer stage when exposed to conditions that induce dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 The life span of dauer-staged animals is either longer or shorter than that observed in control dauer animals. dauer lifespan abnormal C_elegans_phenotype_ontology WBPhenotype:0001540 dauer lifespan variant The life span of dauer-staged animals is either longer or shorter than that observed in control dauer animals. WB:WBPerson2021 Variations in the execution of the developmentally-regulated cell cycle arrest in the gonad during the dauer stage, compared to control. dauer gonad arrest abnormal C_elegans_phenotype_ontology WBPhenotype:0001541 dauer gonad arrest variant Variations in the execution of the developmentally-regulated cell cycle arrest in the gonad during the dauer stage, compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the inhibition of feeding which is induced/occurs during the dauer stage compared to control. dauer feeding suppressed abnormal C_elegans_phenotype_ontology WBPhenotype:0001542 dauer feeding suppressed variant Any variation in the inhibition of feeding which is induced/occurs during the dauer stage compared to control. WB:WBPerson2021 WB:WBPerson557 Dauer stage animals exhibit a decrease in self-propelled movement on a solid medium compared to control animals. dauer reduced locomotion abnormal C_elegans_phenotype_ontology WBPhenotype:0001543 dauer reduced locomotion variant Dauer stage animals exhibit a decrease in self-propelled movement on a solid medium compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the state or activity of a dauer stage organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus, compared to control. dauer sensory response abnormal C_elegans_phenotype_ontology WBPhenotype:0001544 dauer sensory response variant Variations in the state or activity of a dauer stage organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus, compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the overall structure or appearance of an animal progressing through an alternative larval stage in response to environmental stresses compared to control animals. dauer body morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001545 dauer body morphology variant Any variation in the overall structure or appearance of an animal progressing through an alternative larval stage in response to environmental stresses compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations which lead to the decreased ability of dauer larva to survive at extreme conditions, such as high or low temperatures, the presence of dilute acids, detergents, anesthetics, or even fixatives, compared to control (Wormatlas). dauer resistance to harsh conditions abnormal C_elegans_phenotype_ontology WBPhenotype:0001546 dauer resistance to harsh conditions variant Variations which lead to the decreased ability of dauer larva to survive at extreme conditions, such as high or low temperatures, the presence of dilute acids, detergents, anesthetics, or even fixatives, compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the chemical reactions and pathways that occur during the dauer life stage, compared to control. dauer metabolism abnormal dauer metabolism variant C_elegans_phenotype_ontology WBPhenotype:0001547 dauer metabolism phenotype Animals exhibit variations in the chemical reactions and pathways that occur during the dauer life stage, compared to control. WB:WBPerson2021 Any variation in the ratio of the body length to body width in a dauer stage animal, compared to control. Long thin animals will have a high axial ratio. dauer axial ratio abnormal C_elegans_phenotype_ontology WBPhenotype:0001548 dauer axial ratio variant Any variation in the ratio of the body length to body width in a dauer stage animal, compared to control. Long thin animals will have a high axial ratio. WB:WBPerson557 Dauer stage animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion. dauer gut abnormal C_elegans_phenotype_ontology WBPhenotype:0001549 dauer gut variant Dauer stage animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion. WB:WBPerson2021 WB:WBPerson557 Variations in the form or composition of the cuticle-lined lumenal region which lies just behind the lips at the entrance to the pharyngeal lumen in dauer stage animals compared to control (Wormatlas). dauer buccal cavity morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001550 dauer buccal cavity morphology variant Variations in the form or composition of the cuticle-lined lumenal region which lies just behind the lips at the entrance to the pharyngeal lumen in dauer stage animals compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) during the dauer larva stage, compared to control animals (Wormatlas). The dauer larval stage is a developmentally arrested larval stage that is specialized for survival under harsh, or otherwise unfavorable environmental conditions. dauer cuticle abnormal C_elegans_phenotype_ontology WBPhenotype:0001551 dauer cuticle variant Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) during the dauer larva stage, compared to control animals (Wormatlas). The dauer larval stage is a developmentally arrested larval stage that is specialized for survival under harsh, or otherwise unfavorable environmental conditions. WB:WBPerson2021 WB:WBPerson557 Variations in the form or composition of the mouthparts at the anterior end of the digestive tract during the dauer stage, compared to control. dauer pharynx morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001552 dauer pharynx morphology variant Variations in the form or composition of the mouthparts at the anterior end of the digestive tract during the dauer stage, compared to control. WB:WBPerson2021 WB:WBPerson557 Dauer stage animals exhibit variations in the form, structure or composition of a pair of large cells in the head that fuse to form a single gland whose contents are released into the excretory duct through a specialized secretory membrane, compared to control (Wormatlas). dauer excretory gland abnormal C_elegans_phenotype_ontology WBPhenotype:0001553 dauer excretory gland variant Dauer stage animals exhibit variations in the form, structure or composition of a pair of large cells in the head that fuse to form a single gland whose contents are released into the excretory duct through a specialized secretory membrane, compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Dauer stage animals exhibit variations in the form, structure or composition of any portion of the extreme anterior part of their body compared to control. dauer nose morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001554 dauer nose morphology variant Dauer stage animals exhibit variations in the form, structure or composition of any portion of the extreme anterior part of their body compared to control. WB:WBPerson2021 WB:WBPerson557 Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the dauer sensory system, compared to control. The dauer sensory system is used to perceive the physical and chemical environment during the dauer larval stage. dauer sensory system morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001555 dauer sensory system morphology variant Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the dauer sensory system, compared to control. The dauer sensory system is used to perceive the physical and chemical environment during the dauer larval stage. WB:WBPerson2021 WB:WBPerson557 Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in control animals. dauer sensillum abnormal C_elegans_phenotype_ontology WBPhenotype:0001556 dauer sensillum variant Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Dauer stage animals exhibit variations in the quantity, structure or organization of the sensilla of the mouth compared to control. In C. elegans, these sensillum are arranged in two (inner and outer) concentric rings around the mouth. dauer labial sensillum abnormal C_elegans_phenotype_ontology WBPhenotype:0001557 dauer labial sensillum variant Dauer stage animals exhibit variations in the quantity, structure or organization of the sensilla of the mouth compared to control. In C. elegans, these sensillum are arranged in two (inner and outer) concentric rings around the mouth. WB:WBPerson2021 WB:WBPerson557 Dauer stage animals exhibit variations in the quantity, structure or organization of any component of any specialized chemosensory organs located on the head, compared to that observed in control animals. dauer amphid sensillum abnormal C_elegans_phenotype_ontology WBPhenotype:0001558 dauer amphid sensillum variant Dauer stage animals exhibit variations in the quantity, structure or organization of any component of any specialized chemosensory organs located on the head, compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the sensilla situated laterally in the anterior (ADE) or the posterior (PDE) of the animal compared to control. In C. elegans, each of the 4 deirid sensilla (2ADE, 2 PDE) contains a pair of neurons with ciliated dendritic processes that lie in a channel formed by a socket cell and invaginated sheath cell. The cilia of the deirids terminate in the subcuticle and are not exposed to the outside; however occasionally take up FITC. dauer deirid sensillum abnormal C_elegans_phenotype_ontology WBPhenotype:0001559 dauer deirid sensillum variant Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the sensilla situated laterally in the anterior (ADE) or the posterior (PDE) of the animal compared to control. In C. elegans, each of the 4 deirid sensilla (2ADE, 2 PDE) contains a pair of neurons with ciliated dendritic processes that lie in a channel formed by a socket cell and invaginated sheath cell. The cilia of the deirids terminate in the subcuticle and are not exposed to the outside; however occasionally take up FITC. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. dauer sensory system plug abnormal C_elegans_phenotype_ontology WBPhenotype:0001560 obsolete dauer sensory system plug variant true OBSOLETE. WB:WBPerson557 Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the inner labial ring compared to control. In C. elegans, the ring is composed of six sensilla, which include associated neurons IL1 & IL2. dauer inner labial sensillum abnormal C_elegans_phenotype_ontology WBPhenotype:0001561 dauer inner labial sensillum variant Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the inner labial ring compared to control. In C. elegans, the ring is composed of six sensilla, which include associated neurons IL1 & IL2. WB:WBPerson2021 WB:WBPerson557 Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the outer labial ring compared to control. In C. elegans, this ring consists of four sensilla (OLQ) or the two additional lateral sensilla (OLL), which are part of the labial sensillum. dauer outer labial sensillum abnormal C_elegans_phenotype_ontology WBPhenotype:0001562 dauer outer labial sensillum variant Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the outer labial ring compared to control. In C. elegans, this ring consists of four sensilla (OLQ) or the two additional lateral sensilla (OLL), which are part of the labial sensillum. WB:WBPerson2021 WB:WBPerson557 Dauer stage animals exhibit variations in the quantity, structure or organization of any component of a specialized sensory organ in the head that contains a CEP receptor neuron, compared to control. In C. elegans, cells in these organs are refractory to FITC dye uptake. dauer cephalic sensillum abnormal C_elegans_phenotype_ontology WBPhenotype:0001563 dauer cephalic sensillum variant Dauer stage animals exhibit variations in the quantity, structure or organization of any component of a specialized sensory organ in the head that contains a CEP receptor neuron, compared to control. In C. elegans, cells in these organs are refractory to FITC dye uptake. WB:WBPerson2021 WB:WBPerson557 The window of production of self-fertilized eggs exceeds or does not extend to the same length as control. duration of self fertility abnormal C_elegans_phenotype_ontology WBPhenotype:0001564 duration of self fertility variant The window of production of self-fertilized eggs exceeds or does not extend to the same length as control. WB:WBPaper00002419 WB:WBPerson712 Failure to execute characteristic response to lysine as defined by control animals. In C. elegans, lysine is an attractant. C_elegans_phenotype_ontology WBPhenotype:0001565 lysine chemotaxis defective Failure to execute characteristic response to lysine as defined by control animals. In C. elegans, lysine is an attractant. WB:WBPaper00001481 WB:WBPaper00001786 WB:WBPerson2021 Any variation in the process that regulates the migration of ventral epidermal cells toward the ventral midline (to encase underlying cells in an epithelial monolayer) in developing embryos compared to control. ventral enclosure abnormal C_elegans_phenotype_ontology WBPhenotype:0001566 ventral enclosure variant Any variation in the process that regulates the migration of ventral epidermal cells toward the ventral midline (to encase underlying cells in an epithelial monolayer) in developing embryos compared to control. WB:WBPaper00027244 WB:WBPerson2021 Nuclei of specific cells are larger compared to control animals. nuclear size increased C_elegans_phenotype_ontology WBPhenotype:0001567 nuclei enlarged Nuclei of specific cells are larger compared to control animals. WB:WBPerson557 Any variation in the export of mRNA from the cell nucleus compared to control. mRNA export abnormal C_elegans_phenotype_ontology WBPhenotype:0001568 mRNA export variant Any variation in the export of mRNA from the cell nucleus compared to control. WB:WBPaper00005960 The characteristic organization of myosin filaments into discrete A-bands within the muscle cells is disrupted. In C. elegans, myosin filaments no longer appear as continuous longitudinally oriented fibers across the muscle quadrants. body wall muscle myosin organization abnormal C_elegans_phenotype_ontology Dim body wall muscle thick myofilament organization abnormal WBPhenotype:0001569 body wall muscle myosin organization defective The characteristic organization of myosin filaments into discrete A-bands within the muscle cells is disrupted. In C. elegans, myosin filaments no longer appear as continuous longitudinally oriented fibers across the muscle quadrants. WB:WBPaper00001894 WB:WBPerson2021 body wall muscle thick myofilament organization abnormal WB:WBPerson2021 The characteristic organization of actin filaments into I-bands is disrupted. In C. elegans, actin filaments no longer appear as thin continuous longitudinal stripes along the muscle quadrants. body wall muscle actin organization abnormal C_elegans_phenotype_ontology body wall muscle thin myofilament organization abnormal WBPhenotype:0001570 body wall muscle actin organization defective The characteristic organization of actin filaments into I-bands is disrupted. In C. elegans, actin filaments no longer appear as thin continuous longitudinal stripes along the muscle quadrants. WB:WBPaper00001894 WB:WBPerson2021 body wall muscle thin myofilament organization abnormal WB:WBPerson2021 Variations in the accumulation of muscle proteins at membranes where adjacent muscle cells contact each other and the hypodermis compared to control. In C. elegans, during early embryonic body wall muscle development, muscle, basement membrane, and hypodermal components are all colocalized in a continuous linear structure at the site of muscle-hypodermal contact. body wall muscle cell polarization abnormal C_elegans_phenotype_ontology WBPhenotype:0001571 body wall muscle cell polarization variant Variations in the accumulation of muscle proteins at membranes where adjacent muscle cells contact each other and the hypodermis compared to control. In C. elegans, during early embryonic body wall muscle development, muscle, basement membrane, and hypodermal components are all colocalized in a continuous linear structure at the site of muscle-hypodermal contact. WB:WBPaper00001895 Animals that are not ordinarily male, exhibit male-specific attributes. In C. elegans, XX animals exhibit male-specific attributes. C_elegans_phenotype_ontology WBPhenotype:0001572 masculinized Animals that are not ordinarily male, exhibit male-specific attributes. In C. elegans, XX animals exhibit male-specific attributes. WB:WBPaper00000178 WB:WBPaper00001206 WB:WBPerson712 Animals exhibit variations in the response to the addition of nicotine compared to that observed in control animals. Nicotine is a cholinergic agonist. nicotine response abnormal C_elegans_phenotype_ontology WBPhenotype:0001573 nicotine response variant Animals exhibit variations in the response to the addition of nicotine compared to that observed in control animals. Nicotine is a cholinergic agonist. WB:WBPerson557 Animals exhibit variations in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology. ATP levels abnormal C_elegans_phenotype_ontology WBPhenotype:0001574 ATP levels variant Animals exhibit variations in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology. WB:WBPerson2021 WB:WBPerson557 Animals exhibit a decrease in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology. C_elegans_phenotype_ontology WBPhenotype:0001575 ATP levels reduced Animals exhibit a decrease in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology. WB:WBPerson2021 WB:WBPerson557 Variations in the spatial distribution of the mitochondria within the cell compared to control. mitochondria spacing abnormal C_elegans_phenotype_ontology WBPhenotype:0001576 mitochondria spacing variant Variations in the spatial distribution of the mitochondria within the cell compared to control. GO:0048311 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the parallel arrangement of mitochondria within a cell compared to control. mitochondria alignment abnormal C_elegans_phenotype_ontology WBPhenotype:0001577 mitochondria alignment variant Animals exhibit variations in the parallel arrangement of mitochondria within a cell compared to control. WB:WBPaper00028954 Animals fail to respond to the concentration of cholinergic agonist that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001578 cholinergic agonist resistant Animals fail to respond to the concentration of cholinergic agonist that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals respond to a cholinergic agonist at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001579 cholinergic agonist hypersensitive Animals respond to a cholinergic agonist at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Any variation in the progression of the controlled breakdown of the nuclear envelope, compared to control. nuclear envelope breakdown abnormal C_elegans_phenotype_ontology WBPhenotype:0001580 Possible XP. nuclear envelope breakdown variant Any variation in the progression of the controlled breakdown of the nuclear envelope, compared to control. GO:0051081 WB:WBPerson2021 WB:WBPerson557 Levels of transcripts associated with genes on the X chromosome are increased compared to control. C_elegans_phenotype_ontology WBPhenotype:0001581 X linked gene expression enhanced Levels of transcripts associated with genes on the X chromosome are increased compared to control. WB:WBPaper00001011 WB:WBPerson712 Levels of transcripts associated with genes on the X chromosome are decreased compared to control. C_elegans_phenotype_ontology WBPhenotype:0001582 X linked gene expression reduced Levels of transcripts associated with genes on the X chromosome are decreased compared to control. WB:WBPaper00001011 WB:WBPerson712 Animals segregate progeny with 3 X chromosomes. C_elegans_phenotype_ontology WBPhenotype:0001583 XXX progeny Animals segregate progeny with 3 X chromosomes. WB:WBPaper00000179 WB:WBPerson712 Any variation in the movement of chromosomes to the spindle equator during mitosis compared to control animals. chromosome alignment at metaphase plate abnormal chromosome alignment at metaphase plate variant C_elegans_phenotype_ontology chromosome congression WBPhenotype:0001584 chromosome alignment variant Any variation in the movement of chromosomes to the spindle equator during mitosis compared to control animals. GO:0051310 WB:WBPerson557 Any variation in a cell's ability to divide asymmetrically to produce two daughter cells with different developmental potentials compared to control. asymmetric cell division abnormal C_elegans_phenotype_ontology WBPhenotype:0001585 asymmetric cell division variant Any variation in a cell's ability to divide asymmetrically to produce two daughter cells with different developmental potentials compared to control. GO:0008356 WB:WBPerson2021 WB:WBPerson557 Animals contain more than one anchor cell. In C. elegans, presumptive ventral uterine cells undergo fate transformation and instead acquire the properties of an anchor cell (often due to defects in lateral signaling). double anchor cell C_elegans_phenotype_ontology WBPhenotype:0001586 multiple anchor cells Animals contain more than one anchor cell. In C. elegans, presumptive ventral uterine cells undergo fate transformation and instead acquire the properties of an anchor cell (often due to defects in lateral signaling). WB:WBPaper00001423 WB:WBPerson2021 Animals exhibit variations in the formation and/or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas). actin organization biogenesis variant actin organization biogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0001587 Possible XP. actin organization biogenesis phenotype Animals exhibit variations in the formation and/or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas). GO:0030036 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure, composition or arrangement of a robust macromolecular array, composed primarily of tubulin, which forms long extended cytoskeletal elements compared to control (Wormatlas). microtubule organization biogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0001588 Possible XP. microtubule organization biogenesis variant Animals exhibit variations in the form, structure, composition or arrangement of a robust macromolecular array, composed primarily of tubulin, which forms long extended cytoskeletal elements compared to control (Wormatlas). GO:0000226 WB:WBPerson2021 WB:WBPerson557 Any variation that alters the characteristic de novo formation of a microtubule compared to control. microtubule nucleation abnormal C_elegans_phenotype_ontology WBPhenotype:0001589 microtubule nucleation variant Any variation that alters the characteristic de novo formation of a microtubule compared to control. GO:0007020 Any variation that alters the characteristic removal of tubulin heterodimers from one or both ends of a microtubule compared to control. microtubule depolymerization abnormal C_elegans_phenotype_ontology WBPhenotype:0001590 microtubule depolymerization variant Any variation that alters the characteristic removal of tubulin heterodimers from one or both ends of a microtubule compared to control. GO:0007019 Any variation that alters the characteristic addition of tubulin heterodimers to one or both ends of a microtubule compared to control. microtubule polymerization abnormal C_elegans_phenotype_ontology WBPhenotype:0001591 microtubule polymerization variant Any variation that alters the characteristic addition of tubulin heterodimers to one or both ends of a microtubule compared to control. GO:0046785 Alternating periods of stopping and moving; Motion is interrupted by periods of inactivity lasting several seconds. C_elegans_phenotype_ontology WBPhenotype:0001592 fainter Alternating periods of stopping and moving; Motion is interrupted by periods of inactivity lasting several seconds. WB:WBPaper00031286 Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, compared to control. In C. elegans this silencing occurs only in the germline. transgene silencing abnormal C_elegans_phenotype_ontology WBPhenotype:0001593 transgene silencing variant Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, compared to control. In C. elegans this silencing occurs only in the germline. WB:WBPaper00005399 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, in the germline, compared to control. germline transgene silencing abnormal C_elegans_phenotype_ontology WBPhenotype:0001594 germline transgene silencing variant Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, in the germline, compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, in the soma, compared to control. somatic transgene silencing abnormal C_elegans_phenotype_ontology WBPhenotype:0001595 somatic transgene silencing variant Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, in the soma, compared to control. WB:WBPerson2021 WB:WBPerson557 Swelling of the tail hypodermis resulting in a prematurely-truncated and thickened appearance of the tail. In C. elegans, this is usually applies to hermaphrodites. C_elegans_phenotype_ontology WBPhenotype:0001596 tail bobbed Swelling of the tail hypodermis resulting in a prematurely-truncated and thickened appearance of the tail. In C. elegans, this is usually applies to hermaphrodites. WB:WBPaper00024194 WB:WBPerson712 Any variation that results in a fewer than control number of muscle cells. C_elegans_phenotype_ontology WBPhenotype:0001597 muscle missing Any variation that results in a fewer than control number of muscle cells. WB:WBPaper00001423 WB:WBPaper00002946 WB:WBPerson2021 Treatment with inhibitors of serotonin reuptake does not elicit the same response as observed for control animals. inhibitor of serotonin uptake abnormal C_elegans_phenotype_ontology WBPhenotype:0001598 inhibitor of serotonin uptake variant Treatment with inhibitors of serotonin reuptake does not elicit the same response as observed for control animals. WB:WBPerson712 Animals fail to respond to the concentration of ouabain that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans, resistance to ouabain is often assayed via body contraction response. C_elegans_phenotype_ontology WBPhenotype:0001599 ouabain resistant Animals fail to respond to the concentration of ouabain that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans, resistance to ouabain is often assayed via body contraction response. WB:WBPaper00000484 WB:WBPerson2021 Animals require increased concentration or longer exposure to ouabain to elicit the rapid muscular contractions seen in control animals. C_elegans_phenotype_ontology WBPhenotype:0001600 contraction response to ouabain resistant Animals require increased concentration or longer exposure to ouabain to elicit the rapid muscular contractions seen in control animals. WB:WBPaper00000484 Animals fail to respond to the concentration of biogenic amine receptor antagonist that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. serotonin receptor antagonist C_elegans_phenotype_ontology WBPhenotype:0001601 biogenic amine receptor antagonist resistant Animals fail to respond to the concentration of biogenic amine receptor antagonist that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson712 Animals fail to respond to the concentration of methiothepin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001602 methiothepin resistant Animals fail to respond to the concentration of methiothepin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPaper00031241 WB:WBPerson721 Animals fail to respond to the concentration of cyproheptadine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001603 cyproheptadine resistant Animals fail to respond to the concentration of cyproheptadine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPaper00031241 WB:WBPerson721 Animals fail to respond to the concentration of mianserin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology dibenzazepine resistant WBPhenotype:0001604 mianserin resistant Animals fail to respond to the concentration of mianserin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPaper00031241 WB:WBPerson721 Animals do not live longer in response to mianserin compared to control. C_elegans_phenotype_ontology WBPhenotype:0001605 extended life span response to mianserin resistant Animals do not live longer in response to mianserin compared to control. WB:WBPaper00031241 WB:WBPerson721 Animals respond to ethanol at a lower concentration or a shorter exposure compared to control animals. alcohol sensitive C_elegans_phenotype_ontology WBPhenotype:0001606 ethanol hypersensitive Animals respond to ethanol at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00002358 WB:WBPerson712 Animals become paralyzed in response to ethanol at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001607 paralysis response to ethanol hypersensitive Animals become paralyzed in response to ethanol at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00002358 WB:WBPerson712 Animals respond to the anesthetic enflurane at lower concentrations or shorter exposure times than control animals. C_elegans_phenotype_ontology ether hypersensitive WBPhenotype:0001608 enflurane hypersensitive Animals respond to the anesthetic enflurane at lower concentrations or shorter exposure times than control animals. WB:WBPaper00002037 WB:WBPerson721 Animals respond to the anesthetic isoflurane at lower concentrations or shorter response times than control animals. C_elegans_phenotype_ontology ether hypersensitive WBPhenotype:0001609 isoflurane hypersensitive Animals respond to the anesthetic isoflurane at lower concentrations or shorter response times than control animals. WB:WBPaper00002037 WB:WBPerson721 Animals respond to the anesthetic ether at lower concentrations or shorter response times than control animals. C_elegans_phenotype_ontology ether hypersensitive WBPhenotype:0001610 diethyl ether hypersensitive Animals respond to the anesthetic ether at lower concentrations or shorter response times than control animals. WB:WBPaper00001063 WB:WBPaper00002037 WB:WBPerson721 Animals respond to the lipid-soluble anesthetic halothane at lower concentrations or shorter response times compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001611 halothane hypersensitive Animals respond to the lipid-soluble anesthetic halothane at lower concentrations or shorter response times compared to control animals. WB:WBPaper00000958 WB:WBPaper00031286 WB:WBPerson721 Animals fail to respond to the concentration of ethanol that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to ethanol to elicit the response compared to control animals. In C.elegans the phenotype designation Jud is short for JUDang, which is Korean for resistant to alcohol. Jud alcohol resistant C_elegans_phenotype_ontology WBPhenotype:0001612 ethanol resistant Animals fail to respond to the concentration of ethanol that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to ethanol to elicit the response compared to control animals. In C.elegans the phenotype designation Jud is short for JUDang, which is Korean for resistant to alcohol. WB:WBPaper00002358 WB:WBPaper00031371 WB:WBPerson557 WB:WBPerson712 Animals in the presence of ethanol continue to respond to touch under conditions when control worms have stopped responding to stimuli. C_elegans_phenotype_ontology WBPhenotype:0001613 paralysis response to ethanol resistant Animals in the presence of ethanol continue to respond to touch under conditions when control worms have stopped responding to stimuli. WB:WBPaper00031371 WB:WBPerson712 Animals exhibit variations in their response to a specific anticonvulsant compared to that observed in control animals. anticonvulsant response abnormal C_elegans_phenotype_ontology WBPhenotype:0001614 anticonvulsant response variant Animals exhibit variations in their response to a specific anticonvulsant compared to that observed in control animals. WB:WBPerson557 Animals fail to respond to the concentration of compounds that act as anticonvulsants that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001615 anticonvulsant resistant Animals fail to respond to the concentration of compounds that act as anticonvulsants that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPaper00024698 WB:WBPerson557 WB:WBPerson712 Animals fail to respond to the concentration of trimethadione, which acts as an anticonvulsant, that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001616 trimethadione resistant Animals fail to respond to the concentration of trimethadione, which acts as an anticonvulsant, that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPaper00024698 WB:WBPerson557 WB:WBPerson712 Animals fail to respond to the concentration of ethosuximide, which acts as an anticonvulsant, that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001617 ethosuximide resistant Animals fail to respond to the concentration of ethosuximide, which acts as an anticonvulsant, that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson712 Animals fail to respond to the concentration of the anesthetic halothane that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001618 halothane resistant Animals fail to respond to the concentration of the anesthetic halothane that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPaper00004721 WB:WBPerson557 WB:WBPerson712 Animals fail to respond to the concentration of the volatile anesthetic isoflurane that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001619 isoflurane resistant Animals fail to respond to the concentration of the volatile anesthetic isoflurane that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPaper00004721 WB:WBPerson712 Animals exhibit variations in their response to oxidative stress compared to that observed in control animals. organism oxidative stress response abnormal C_elegans_phenotype_ontology WBPhenotype:0001620 organism oxidative stress response variant Animals exhibit variations in their response to oxidative stress compared to that observed in control animals. WB:WBPerson557 Animals respond to a lower concentration of reactive oxygen species or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001621 organism oxidative stress response hypersensitive Animals respond to a lower concentration of reactive oxygen species or a shorter exposure compared to control animals. WB:WBPerson2021 Animals lay eggs at a greater rate in response to exogenous serotonin compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001622 egg laying serotonin hypersensitive Animals lay eggs at a greater rate in response to exogenous serotonin compared to control animals. WB:WBPaper00002487 WB:WBPerson712 Any variation in the posture of the male tail after application of exogenous serotonin compared to control. In C. elegans, males respond with a tight ventral curling of the male tail in response to serotonin. male tail curling serotonin abnormal C_elegans_phenotype_ontology WBPhenotype:0001623 male tail curling serotonin variant Any variation in the posture of the male tail after application of exogenous serotonin compared to control. In C. elegans, males respond with a tight ventral curling of the male tail in response to serotonin. WB:WBPaper00001861 WB:WBPerson557 Animals fail to respond to the concentration of serotonin that elicits a male tail curling response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans males respond to serotonin with a tight ventral curling of the male tail and posterior body. C_elegans_phenotype_ontology WBPhenotype:0001624 male tail curling serotonin resistant Animals fail to respond to the concentration of serotonin that elicits a male tail curling response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans males respond to serotonin with a tight ventral curling of the male tail and posterior body. WB:WBPaper00001861 WB:WBPerson557 Males respond to serotonin by curling their tails at a lower concentration or a shorter exposure compared to control animals. In C. elegans males respond to serotonin with a tight ventral curling of the male tail and posterior body. C_elegans_phenotype_ontology WBPhenotype:0001625 male tail curling serotonin hypersensitive Males respond to serotonin by curling their tails at a lower concentration or a shorter exposure compared to control animals. In C. elegans males respond to serotonin with a tight ventral curling of the male tail and posterior body. WB:WBPaper00001861 WB:WBPaper00028762 WB:WBPerson557 Any variation in the locomotion rate after application of exogenous serotonin compared to control. locomotion rate serotonin abnormal C_elegans_phenotype_ontology WBPhenotype:0001626 locomotion rate serotonin variant Any variation in the locomotion rate after application of exogenous serotonin compared to control. WB:WBPaper00002141 The decrease in locomotion rate in the presence of serotonin is greater than control animals. C_elegans_phenotype_ontology locomotion rate serotonin reduced WBPhenotype:0001627 locomotion rate serotonin hypersensitive The decrease in locomotion rate in the presence of serotonin is greater than control animals. WB:WBPaper00002141 Animals fail to decrease their locomotion rate in response the concentration of serotonin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology locomotion rate serotonin increased WBPhenotype:0001628 locomotion rate serotonin resistant Animals fail to decrease their locomotion rate in response the concentration of serotonin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPaper00002141 Any variation in egg laying behavior after application of exogenous serotonin compared to control. In C. elegans, serotonin induces egg laying. egg laying serotonin abnormal C_elegans_phenotype_ontology WBPhenotype:0001629 egg laying serotonin variant Any variation in egg laying behavior after application of exogenous serotonin compared to control. In C. elegans, serotonin induces egg laying. WB:WBPaper00000635 WB:WBPerson712 Any variation in the developmental progression of the intestine that leads to a blockage in the alimentary canal. Gob C_elegans_phenotype_ontology WBPhenotype:0001630 gut obstructed Any variation in the developmental progression of the intestine that leads to a blockage in the alimentary canal. WB:WBPerson2021 WB:WBPerson557 Animals produce ova/sperm that contain no X chromosome in a nonmendelian segregation pattern. nullo X gamete abnormal C_elegans_phenotype_ontology WBPhenotype:0001631 nullo X gamete Animals produce ova/sperm that contain no X chromosome in a nonmendelian segregation pattern. WB:WBPaper00000179 WB:WBPerson712 Animals produce ova/sperm that contain 2 X chromosomes. C_elegans_phenotype_ontology WBPhenotype:0001632 diplo X gamete Animals produce ova/sperm that contain 2 X chromosomes. WB:WBPaper00000179 WB:WBPerson712 Animals produce ova/sperm that contain lethal factors as a result of chromosomal disjunction defects. C_elegans_phenotype_ontology WBPhenotype:0001633 lethal gamete Animals produce ova/sperm that contain lethal factors as a result of chromosomal disjunction defects. WB:WBPaper00000179 WB:WBPerson712 Animals respond to compounds that elicit electrophilic stress at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001634 organism electrophilic stress hypersensitive Animals respond to compounds that elicit electrophilic stress at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals contain an excess number of pharyngeal cells compared to control. In C. elegans, pharyngeal cells are derived from MS-blastomere. The overproduction of pharyngeal tissues is a result of other blastomeres adopting an MS-like fate. C_elegans_phenotype_ontology WBPhenotype:0001635 excess pharyngeal cells Animals contain an excess number of pharyngeal cells compared to control. In C. elegans, pharyngeal cells are derived from MS-blastomere. The overproduction of pharyngeal tissues is a result of other blastomeres adopting an MS-like fate. WB:WBPaper00001584 WB:WBPaper00002922 WB:WBperson2021 Animals contain an excess number of intestinal cells compared to control. In C. elegans, intestinal cells are derived from E-blastomere. The overproduction of intestinal tissues is a result of other blastomeres adopting an E-like fate or excess cell proliferation in the E lineage. C_elegans_phenotype_ontology WBPhenotype:0001636 excess intestinal cells Animals contain an excess number of intestinal cells compared to control. In C. elegans, intestinal cells are derived from E-blastomere. The overproduction of intestinal tissues is a result of other blastomeres adopting an E-like fate or excess cell proliferation in the E lineage. WB:WBPaper00001584 WB:WBPaper00002330 WB:WBperson2021 Embryos fail to generate cells that exhibit intestinal specification. In C. elegans, the E blastomere is the precursor of all the intestinal cells. C_elegans_phenotype_ontology WBPhenotype:0001637 no Intestine Embryos fail to generate cells that exhibit intestinal specification. In C. elegans, the E blastomere is the precursor of all the intestinal cells. WB:WBPaper00002946 WB:WBperson2021 OBSOLETE: Animals are deficient in the formation or disassembly of lysosomes. C_elegans_phenotype_ontology WBPhenotype:0001638 obsolete endosome fusion defective true OBSOLETE: Animals are deficient in the formation or disassembly of lysosomes. GO:0034058 WB:WBPaper00029049 WB:WBPerson712 Animals exhibit a decrease in their high-speed movement in the forward direction with brief backward movement compared to control. In C. elegans, Animals do not move more than a few body lengths from their starting position and searches occur locally with pivoting behavior. C_elegans_phenotype_ontology lurcher path range decreased WBPhenotype:0001639 roaming reduced Animals exhibit a decrease in their high-speed movement in the forward direction with brief backward movement compared to control. In C. elegans, Animals do not move more than a few body lengths from their starting position and searches occur locally with pivoting behavior. WB:WBPaper00003743 WB:WBPaper00031455 WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 WB:WBPerson712 Animals are unable to acidify compartments to the same level as that observed in control animals given the same stimulus. acidification level abnormal C_elegans_phenotype_ontology WBPhenotype:0001640 acidification level defective Animals are unable to acidify compartments to the same level as that observed in control animals given the same stimulus. WB:WBPaper00031246 WB:WBPerson712 Animals lack or exhibit defects in the posterior body muscle contractions during the defecation cycle. C_elegans_phenotype_ontology pBoc WBPhenotype:0001641 posterior body wall contraction defective Animals lack or exhibit defects in the posterior body muscle contractions during the defecation cycle. WB:WBPaper00031426 WB:WBPerson712 Variations that disrupt stereotypical embryonic cleavage patterns (such as cleavage rate, division axes or asymmetric division). C_elegans_phenotype_ontology WBPhenotype:0001642 cell cleavage variant emb Variations that disrupt stereotypical embryonic cleavage patterns (such as cleavage rate, division axes or asymmetric division). GO:0040016 WB:WBPaper00001032 WB:WBPerson2021 Embryos generate an excess number of hypodermal cells compared to control. Skn C_elegans_phenotype_ontology WBPhenotype:0001643 excess hypodermal cells Embryos generate an excess number of hypodermal cells compared to control. WB:WBPerson2021 Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of proteins in the organism compared to control. protein metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0001644 protein metabolism variant Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of proteins in the organism compared to control. WB:WBPerson557 Variations in the chemical reactions and pathways resulting in the directed breakdown of a protein (via the destruction of its native, active configuration) compared to control. protein degradation abnormal C_elegans_phenotype_ontology WBPhenotype:0001645 protein degradation variant Variations in the chemical reactions and pathways resulting in the directed breakdown of a protein (via the destruction of its native, active configuration) compared to control. GO:0030163 WB:WBPerson2021 Embryos fail to generate cells that exhibit pharyngeal specification. Pha C_elegans_phenotype_ontology WBPhenotype:0001646 no pharynx Embryos fail to generate cells that exhibit pharyngeal specification. WB:WBPaper00001521 WB:WBPerson2021 Any variation in the progression of the posterior portion of the pharynx over time compared to control. In C. elegans the posterior region includes the isthmus and terminal bulb (second bulb). posterior pharynx abnormal C_elegans_phenotype_ontology WBPhenotype:0001647 posterior pharynx variant Any variation in the progression of the posterior portion of the pharynx over time compared to control. In C. elegans the posterior region includes the isthmus and terminal bulb (second bulb). WB:WBPerson2021 WB:WBPerson557 Embryos fail to generate cells that give rise to the posterior portion of the pharynx. In C. elegans, the MS blastomere- derived pharyngeal cells constitute the posterior portion of the pharynx. C_elegans_phenotype_ontology WBPhenotype:0001648 no posterior pharynx Embryos fail to generate cells that give rise to the posterior portion of the pharynx. In C. elegans, the MS blastomere- derived pharyngeal cells constitute the posterior portion of the pharynx. WB:WBPaper00002330 WB:WBPerson2021 Animals fail to respond to the concentration of Fluorouracil (5-FU) that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. Elegans Fluorouracil induces germ cell death, inhibits embryogenesis and inhibits larval growth (depending on dose) in control animals. 5 FU resistant C_elegans_phenotype_ontology WBPhenotype:0001649 Fluorouracil resistant Animals fail to respond to the concentration of Fluorouracil (5-FU) that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. Elegans Fluorouracil induces germ cell death, inhibits embryogenesis and inhibits larval growth (depending on dose) in control animals. WB:WBPaper00031571 WB:WBPerson721 Germ cell death fails in response to the concentration of 5-FU that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans, in addition to cell death, 5-FU exposed animals exhibit condensed germ cell nuclei or unhealthy nuclei. C_elegans_phenotype_ontology WBPhenotype:0001650 germ cell death response to 5 FU resistant Germ cell death fails in response to the concentration of 5-FU that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans, in addition to cell death, 5-FU exposed animals exhibit condensed germ cell nuclei or unhealthy nuclei. WB:WBPaper00031571 WB:WBPerson721 Animals grow well during or after exposure to 5-FU under conditions where control animals are growth inhibited. C_elegans_phenotype_ontology WBPhenotype:0001651 growth arrest response to 5 FU resistant Animals grow well during or after exposure to 5-FU under conditions where control animals are growth inhibited. WB:WBPaper00031571 WB:WBPerson721 Any variation in the process by which the gonad anchor cell makes contact with vulval cells in order to create a uterine-vulval connection. In C. elegans, this includes the loss of the basement membranes between these cells and the crossing of the basolateral portion of the anchor cell through this gap. anchor cell invasion abnormal C_elegans_phenotype_ontology WBPhenotype:0001652 anchor cell invasion variant Any variation in the process by which the gonad anchor cell makes contact with vulval cells in order to create a uterine-vulval connection. In C. elegans, this includes the loss of the basement membranes between these cells and the crossing of the basolateral portion of the anchor cell through this gap. WB:WBPaper00005989 Animals exhibit variations in their response to cadmium compared to that observed in control animals. cadmium response abnormal C_elegans_phenotype_ontology WBPhenotype:0001653 cadmium response variant Animals exhibit variations in their response to cadmium compared to that observed in control animals. WB:WBPerson557 Animals fail to respond to the concentration of cadmium that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to cadmium to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001654 cadmium resistant Animals fail to respond to the concentration of cadmium that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to cadmium to elicit the response compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals respond to cadmium at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001655 cadmium hypersensitive Animals respond to cadmium at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Any variation in the progression of the leader cell that guides and shapes the outgrowth of the gonad while crawling along the body wall to force the germline to extend into a long tubular shape over time from its formation to its mature structure compared to control. distal tip cell development abnormal C_elegans_phenotype_ontology WBPhenotype:0001656 distal tip cell development variant Any variation in the progression of the leader cell that guides and shapes the outgrowth of the gonad while crawling along the body wall to force the germline to extend into a long tubular shape over time from its formation to its mature structure compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the specialized region of connection between two cells or between a cell and the extracellular matrix compared to control. cell junction abnormal C_elegans_phenotype_ontology WBPhenotype:0001657 cell junction variant Animals exhibit variations in the specialized region of connection between two cells or between a cell and the extracellular matrix compared to control. GO:0030054 WB:WBPaper00031590 WB:WBPerson712 Animals exhibit variations in the specialized region of connection between two cells compared to control. intercellular junction abnormal C_elegans_phenotype_ontology cell cell junction abnormal WBPhenotype:0001658 intercellular junction variant Animals exhibit variations in the specialized region of connection between two cells compared to control. GO:0005911 WB:WBPaper00031590 WB:WBPerson712 Any variation in the form, structure or composition of the somatic gonad structure that connects the distal gonad arm to the uterus compared to control (Wormatlas). spermatheca morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001659 spermatheca morphology variant Any variation in the form, structure or composition of the somatic gonad structure that connects the distal gonad arm to the uterus compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The two morphologically bilaterally symmetric gustatory neurons ASE left (ASEL) and ASE right (ASER) fail to undergo a left/right asymmetric diversification in cell fate. 2ASEL 2ASER C_elegans_phenotype_ontology WBPhenotype:0001660 loss of asymmetry ASE The two morphologically bilaterally symmetric gustatory neurons ASE left (ASEL) and ASE right (ASER) fail to undergo a left/right asymmetric diversification in cell fate. WB:WBPaper00030973 WB:WBPerson2021 The two morphologically bilaterally symmetric olfactory neurons AWC left (AWCL) and AWC right (AWCR) fail to undergo a left/right asymmetric diversification in cell fate. 2 AWC off 2 AWC on C_elegans_phenotype_ontology WBPhenotype:0001661 loss of asymmetry AWC The two morphologically bilaterally symmetric olfactory neurons AWC left (AWCL) and AWC right (AWCR) fail to undergo a left/right asymmetric diversification in cell fate. WB:WBPaper00003760 WB:WBPerson2021 Any variation in the progression of the somatic gonad structure that connects the distal gonad arm to the uterus over time from an initial condition to a later condition compared to control animals. spermatheca development abnormal C_elegans_phenotype_ontology WBPhenotype:0001662 spermatheca development variant Any variation in the progression of the somatic gonad structure that connects the distal gonad arm to the uterus over time from an initial condition to a later condition compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals fail to respond to the levels of reactive oxygen species that elicit a response in control animals. Oxr C_elegans_phenotype_ontology WBPhenotype:0001663 organism oxidative stress resistant Animals fail to respond to the levels of reactive oxygen species that elicit a response in control animals. WB:WBPerson2021 The frequency of sex chromosome segregation is perturbed, resulting in the production of exceptional gametes (e.g. ova or sperm) and populations with a sex ratio altered from the rate of 1:500 as observed for control populations. C_elegans_phenotype_ontology WBPhenotype:0001664 X chromosome nondisjunction The frequency of sex chromosome segregation is perturbed, resulting in the production of exceptional gametes (e.g. ova or sperm) and populations with a sex ratio altered from the rate of 1:500 as observed for control populations. WB:WBPaper00000179 WB:WBPaper00000565 WB:WBPerson712 Lower numbers of male progeny occur in the population compared to control populations. In C. elegans, the low incidence of males phenotype in a self-fertilizing hermaphrodite population is a result of an decrease in X chromosome nondisjunction. C_elegans_phenotype_ontology WBPhenotype:0001665 low incidence male progeny Lower numbers of male progeny occur in the population compared to control populations. In C. elegans, the low incidence of males phenotype in a self-fertilizing hermaphrodite population is a result of an decrease in X chromosome nondisjunction. WB:WBPaper00000565 WB:WBPerson712 Animals respond to iononizing radiation at a lower dose or a shorter exposure compared to control animals. Iononizing radiation has a wavelength in the 10 to 0.01 nanometer range. In C. elegans, increased sensitivity to X-ray irradiation is often observed as a decrease in survival upon exposure compared to control animals given the same treatment. C_elegans_phenotype_ontology WBPhenotype:0001666 organism hypersensitive X ray irradiation Animals respond to iononizing radiation at a lower dose or a shorter exposure compared to control animals. Iononizing radiation has a wavelength in the 10 to 0.01 nanometer range. In C. elegans, increased sensitivity to X-ray irradiation is often observed as a decrease in survival upon exposure compared to control animals given the same treatment. WB:WBPaper00000565 WB:WBPaper00003886 WB:WBPerson712 Animals respond to the chemical mutagen methyl methanesulfonate (MMS) a methanesulfonate ester and alkylating agent at a lower concentration or a shorter exposure compared to control animals. In C. elegans, increased sensitivity to MMS can be observed as a decrease in egg hatch upon acute exposure or inhibition of growth after chronic exposure compared to control animals given the same treatment. MMS hypersensitive C_elegans_phenotype_ontology WBPhenotype:0001667 methyl methanesulfonate hypersensitive Animals respond to the chemical mutagen methyl methanesulfonate (MMS) a methanesulfonate ester and alkylating agent at a lower concentration or a shorter exposure compared to control animals. In C. elegans, increased sensitivity to MMS can be observed as a decrease in egg hatch upon acute exposure or inhibition of growth after chronic exposure compared to control animals given the same treatment. WB:WBPaper00000565 WB:WBPerson712 An increased number of oocytes are retained in the gonad without becoming endomitotic, compared to control. C_elegans_phenotype_ontology oocyte number increased WBPhenotype:0001668 oocyte accumulation An increased number of oocytes are retained in the gonad without becoming endomitotic, compared to control. WB:WBPaper00006281 WB:WBPaper00030855 Animals exhibit a variation in the ratio of synaptic vesicles per synapse of a neuron, compared to control animals. presynaptic vesicle number abnormal C_elegans_phenotype_ontology synaptic vesicle number abnormal WBPhenotype:0001669 presynaptic vesicle number variant Animals exhibit a variation in the ratio of synaptic vesicles per synapse of a neuron, compared to control animals. WB:WBPaper00027305 WB:WBPerson712 Animals exhibit an overall decrease in the quantity of synaptic vesicles at the synapse compared to control animals. WBPhenotype:0001322 C_elegans_phenotype_ontology synaptic vesicle number reduced WBPhenotype:0001670 presynaptic vesicle number reduced Animals exhibit an overall decrease in the quantity of synaptic vesicles at the synapse compared to control animals. WB:WBPaper00027305 WB:WBPerson712 Animals display variations in the distribution of spherical membrane-bound fluid-filled organelles, compared to that observed in control animals. vesicle organization abnormal C_elegans_phenotype_ontology WBPhenotype:0001671 vesicle organization variant Animals display variations in the distribution of spherical membrane-bound fluid-filled organelles, compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the extension of the part of the axon that forms a bridge between body regions, compared to control animals. commisure growth abnormal C_elegans_phenotype_ontology WBPhenotype:0001672 commisure growth variant Animals exhibit variations in the extension of the part of the axon that forms a bridge between body regions, compared to control animals. WB:WBPerson2021 WB:WBPerson712 Animals exhibit variations in the processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA, which allow the chromosome to persist from generation to generation, compared to control. telomere homeostasis abnormal C_elegans_phenotype_ontology WBPhenotype:0001673 telomere homeostasis variant Animals exhibit variations in the processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA, which allow the chromosome to persist from generation to generation, compared to control. GO:0032204 WB:WBPaper00031585 WB:WBPerson712 Animals exhibit variations in the sequence or organization of the components of the terminal region of its chromosome, (i.e. telomere, which serves to stabilize the chromosome) compared to control. telomere morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001674 telomere morphology variant Animals exhibit variations in the sequence or organization of the components of the terminal region of its chromosome, (i.e. telomere, which serves to stabilize the chromosome) compared to control. GO:0000781 WB:WBPaper00003886 WB:WBPerson712 Males exhibit variations in the reproductive system, from its formation to the mature structure compared to control. male gonad development abnormal C_elegans_phenotype_ontology WBPhenotype:0001675 male gonad development variant Males exhibit variations in the reproductive system, from its formation to the mature structure compared to control. WB:WBPerson712 Animals exhibit variations in the structure or composition of any neuron within the class of sensory neurons responsible for relaying mechanical stimuli to the animal compared to control. touch receptor cell morphology abnormal C_elegans_phenotype_ontology mechanosensory neuron abnormal microtubule cell morphology abnormal WBPhenotype:0001676 touch receptor cell morphology variant Animals exhibit variations in the structure or composition of any neuron within the class of sensory neurons responsible for relaying mechanical stimuli to the animal compared to control. WB:WBPaper00000550 WB:WBPerson712 Animals display cuticle components displayed by animals of a different developmental stage, compared to control. Srf stage specific cuticle antigenicity abnormal C_elegans_phenotype_ontology WBPhenotype:0001677 stage specific cuticle antigenicity variant Animals display cuticle components displayed by animals of a different developmental stage, compared to control. WB:WBPaper00002589 WB:WBPerson712 Animals produce cuticles that vary in components such as proteins or carbohydrates, observed in control animals of the same developmental stage and raised under the same conditions. cuticle physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001678 cuticle physiology variant Animals produce cuticles that vary in components such as proteins or carbohydrates, observed in control animals of the same developmental stage and raised under the same conditions. WB:WBPaper00001576 WB:WBPerson712 Neurons have more than one process extending from the cell body. C_elegans_phenotype_ontology WBPhenotype:0001679 multipolar neuron Neurons have more than one process extending from the cell body. WB:WBPaper00031901 WB:WBPerson712 Vulval precursor cells forgo further cell division and fuse to the hypodermis instead of adopting their intended fate (becoming primary, secondary or tertiary vulval cells). C_elegans_phenotype_ontology F fate abnormal VPC fused fate abnormal WBPhenotype:0001680 adoption of fused vulval cell fate Vulval precursor cells forgo further cell division and fuse to the hypodermis instead of adopting their intended fate (becoming primary, secondary or tertiary vulval cells). WB:WBPerson2021 WB:WBPerson712 The alignment of the spindle relative to other cellular structures varies from that observed in control animals. spindle orientation abnormal C_elegans_phenotype_ontology WBPhenotype:0001681 spindle orientation variant The alignment of the spindle relative to other cellular structures varies from that observed in control animals. GO:0051294 WB:WBPaper00031898 WB:WBPerson712 Organisms respond to UV at a higer dose or a longer exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001682 organism UV resistant Organisms respond to UV at a higer dose or a longer exposure compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations that specifically disrupt sperm production in XX hermaphrodites. By contrast, spermatogenesis in XO males remains unaffected. C_elegans_phenotype_ontology WBPhenotype:0001683 spermatogenesis defective hermaphrodite Variations that specifically disrupt sperm production in XX hermaphrodites. By contrast, spermatogenesis in XO males remains unaffected. WB:WBPaper00002113 WB:WBPaper00002631 The rates of synaptic vesicle exocytosis and endocytosis vary from that observed in control animals. synaptic vesicle homeostasis abnormal C_elegans_phenotype_ontology WBPhenotype:0001684 synaptic vesicle homeostasis variant The rates of synaptic vesicle exocytosis and endocytosis vary from that observed in control animals. WB:WBPaper00031872 WB:WBPerson712 The region opposite to the presynaptic region deviates in the structure, configuration or ratio of its components specific for receiving signals from the other side of the synapse compared to control. postsynaptic region morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0001685 postsynaptic region morphology variant The region opposite to the presynaptic region deviates in the structure, configuration or ratio of its components specific for receiving signals from the other side of the synapse compared to control. WB:WBPaper00031872 WB:WBPerson712 Animals exhibit variations in any physical or chemical process in the region, opposite to the presynaptic region, which is required for receiving signals from the other side of the synapse compared to control. postsynaptic region physiology abnormal C_elegans_phenotype_ontology WBPhenotype:0001686 postsynaptic region physiology variant Animals exhibit variations in any physical or chemical process in the region, opposite to the presynaptic region, which is required for receiving signals from the other side of the synapse compared to control. WB:WBPerson2021 WB:WBPerson557 Cuticles of animals or cuticular extracts exhibit an altered pattern of antibody binding compared to Bristol N2 animals of the same developmental stage. Srf surface antigenicity abnormal C_elegans_phenotype_ontology WBPhenotype:0001687 surface antigenicity variant Cuticles of animals or cuticular extracts exhibit an altered pattern of antibody binding compared to Bristol N2 animals of the same developmental stage. WB:WBPaper00001280 WB:WBPerson712 The electron dense, amorphous envelope that comprises the outermost layer of the cuticle varies in composition from that observed in control animals of the same developmental stage. The integrity of the surface coat is often revealed by an altered antigenicity or biochemical make up. Srf surface coat abnormal C_elegans_phenotype_ontology WBPhenotype:0001688 surface coat variant The electron dense, amorphous envelope that comprises the outermost layer of the cuticle varies in composition from that observed in control animals of the same developmental stage. The integrity of the surface coat is often revealed by an altered antigenicity or biochemical make up. GO:0060104 Cuticles or cuticular extracts do not bind antibodies that are observed to bind the surfaces or cuticular extracts of Bristol N2 animals of the same developmental stage. Srf C_elegans_phenotype_ontology WBPhenotype:0001689 surface antigen negative Cuticles or cuticular extracts do not bind antibodies that are observed to bind the surfaces or cuticular extracts of Bristol N2 animals of the same developmental stage. WB:WBPaper00001280 WB:WBPerson712 Animals display surface antigens throughout all larval stages, unlike Bristol N2 worms, which display the antigens only during one larval stage. Cld C_elegans_phenotype_ontology WBPhenotype:0001690 constitutive larval display Animals display surface antigens throughout all larval stages, unlike Bristol N2 worms, which display the antigens only during one larval stage. WB:WBPaper00002589 WB:WBPerson712 Germ nuclei are misplaced in the gonad and are observed in the rachis. Sheath cells are observed protruding between these nuclei. Meiotic or mitotic specification of germ nuclei is not affected. germ line morphogenesis(Glm) C_elegans_phenotype_ontology WBPhenotype:0001691 germ nuclei rachis Germ nuclei are misplaced in the gonad and are observed in the rachis. Sheath cells are observed protruding between these nuclei. Meiotic or mitotic specification of germ nuclei is not affected. WB:WBPaper00031889 WB:WBPerson712 Animals are not induced to display surface antigens by exposure to pheromone as observed for Bristol N2 animals. ILD abnormal pheromone induced larval display abnormal C_elegans_phenotype_ontology induced larval display abnormal WBPhenotype:0001692 pheromone induced larval display defective Animals are not induced to display surface antigens by exposure to pheromone as observed for Bristol N2 animals. WB:WBPaper00002589 WB:WBPerson712 Males have alae that extend into the tail region. Alae are small linear ridges running along the lateral lines of the cuticle. In C. elegans alae do not extend into the tail region (Wormatlas). Pal C_elegans_phenotype_ontology WBPhenotype:0001693 male posterior alae Males have alae that extend into the tail region. Alae are small linear ridges running along the lateral lines of the cuticle. In C. elegans alae do not extend into the tail region (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Hermaphrodites continue to produce sperm past the time at which the transition to oogenesis normally occurs. Thus, germ cells that would normally become oocytes are transformed into sperm instead. spermatogenesis to oogenesis switch abnormal C_elegans_phenotype_ontology WBPhenotype:0001694 spermatogenesis to oogenesis switch defective Hermaphrodites continue to produce sperm past the time at which the transition to oogenesis normally occurs. Thus, germ cells that would normally become oocytes are transformed into sperm instead. WB:WBPaper00001883 WB:WBPaper00002113 WB:WBPerson2021 Animals exhibit variations in their catalytic ability the transfer glycolsyl groups from one compound (donor) to another (acceptor) often measured by a reduction in the amount of glycosylated products compared to that observed in control animals of the same developmental stage. glycosyltransferase activity abnormal C_elegans_phenotype_ontology WBPhenotype:0001695 glycosyltransferase activity variant Animals exhibit variations in their catalytic ability the transfer glycolsyl groups from one compound (donor) to another (acceptor) often measured by a reduction in the amount of glycosylated products compared to that observed in control animals of the same developmental stage. GO:0016757 WB:WBPerson712 Animals exhibit variations in the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones compared to control. biosynthesis abnormal C_elegans_phenotype_ontology WBPhenotype:0001696 biosynthesis variant Animals exhibit variations in the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones compared to control. GO:0009058 WB:WBPaper00029024 WB:WBPerson712 Animals exhibit variations in the chemical reactions and pathways resulting in the formation of chondroitin sulfate compared to control. chondroitin biosynthesis abnormal C_elegans_phenotype_ontology WBPhenotype:0001697 chondroitin biosynthesis variant Animals exhibit variations in the chemical reactions and pathways resulting in the formation of chondroitin sulfate compared to control. WB:WBPaper00029024 WB:WBPaper00031153 WB:WBPerson712 Animals exhibit variations in the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan compared to control. heparan sulfate biosynthesis abnormal C_elegans_phenotype_ontology WBPhenotype:0001698 heparan sulfate biosynthesis variant Animals exhibit variations in the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan compared to control. WB:WBPaper00029024 WB:WBPaper00031153 WB:WBPerson712 Specific body regions of an animal display variations in movement compared to that observed in control animals. localized movement abnormal C_elegans_phenotype_ontology WBPhenotype:0001699 localized movement variant Specific body regions of an animal display variations in movement compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in movement in liquid from that observed for control animals. swimming abnormal C_elegans_phenotype_ontology movement in liquid abnormal thrashing abnormal WBPhenotype:0001700 swimming variant Animals exhibit variations in movement in liquid from that observed for control animals. WB:WBPaper00031835 WB:WBPerson712 Animals exhibit uncharacteristic muscle contractions during the process by which they travel from one location to another. C_elegans_phenotype_ontology convulsive WBPhenotype:0001701 spastic locomotion Animals exhibit uncharacteristic muscle contractions during the process by which they travel from one location to another. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the directional changes that separate consecutive runs, from that observed for control animals. In C. elegans, these aberrations include variations in the form or extent of omega turns or reversals (shifts from forward to backward movements). directionality abnormal C_elegans_phenotype_ontology reversal abnormal turning abnormal WBPhenotype:0001702 directionality variant Animals exhibit variations in the directional changes that separate consecutive runs, from that observed for control animals. In C. elegans, these aberrations include variations in the form or extent of omega turns or reversals (shifts from forward to backward movements). WB:WBPaper00000075 WB:WBPaper00003740 WB:WBPaper00031656 WB:WBPerson712 Any variation in the maximum ventral and dorsal flex of the animal compared to control animals. body bend abnormal C_elegans_phenotype_ontology WBPhenotype:0001703 body bend variant Any variation in the maximum ventral and dorsal flex of the animal compared to control animals. WB:WBPerson2021 WB:WBPerson557 Alae contain more cuticular ridges than control animals. In C. elegans alae are composed of three cuticular ridges. C_elegans_phenotype_ontology WBPhenotype:0001704 multiple alae Alae contain more cuticular ridges than control animals. In C. elegans alae are composed of three cuticular ridges. WB:WBPaper00026841 WB:WBPerson557 The directed movement of molecules between the nucleus and the cytoplasm is impaired. nucleocytoplasmic transport abnormal C_elegans_phenotype_ontology WBPhenotype:0001705 nucleocytoplasmic transport defective The directed movement of molecules between the nucleus and the cytoplasm is impaired. GO:0006913 WB:WBPerson557 The directed movement of substances out of the nucleus is impaired. nuclear export abnormal C_elegans_phenotype_ontology WBPhenotype:0001706 nuclear export defective The directed movement of substances out of the nucleus is impaired. GO:0051168 WB:WBPerson557 The directed movement of substances into the nucleus is impaired. nuclear import abnormal C_elegans_phenotype_ontology WBPhenotype:0001707 nuclear import defective The directed movement of substances into the nucleus is impaired. GO:0051170 WB:WBPerson557 The directed movement of a protein from the nucleus into the cytoplasm is impaired. protein export from nucleus abnormal C_elegans_phenotype_ontology WBPhenotype:0001708 protein export from nucleus defective The directed movement of a protein from the nucleus into the cytoplasm is impaired. GO:0006611 WB:WBPerson557 Animals exhibit variations in light/dark cycle recurrence of reactions to stress conditions compared to that observed for control animals. rhythmic tolerance to stress abnormal C_elegans_phenotype_ontology circadian variation in stress tolerance abnormal WBPhenotype:0001709 rhythmic tolerance to stress variant Animals exhibit variations in light/dark cycle recurrence of reactions to stress conditions compared to that observed for control animals. WB:WBPaper00032037 WB:WBPerson712 Animals exhibit variations in light/dark cycle recurrence of reactions to osmotic stress compared to that observed for control animals. rhythmic tolerance to osmotic stress abnormal C_elegans_phenotype_ontology WBPhenotype:0001710 rhythmic tolerance to osmotic stress variant Animals exhibit variations in light/dark cycle recurrence of reactions to osmotic stress compared to that observed for control animals. WB:WBPaper00032037 WB:WBPerson712 Animals exhibit variations in actions or responses that occur with measurable periodicity, from that observed for control animals. rhythmic behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0001711 rhythmic behavior variant Animals exhibit variations in actions or responses that occur with measurable periodicity, from that observed for control animals. GO:0007622 WB:WBPerson712 Animals exhibit variations in the actions or reactions that recur with a periodicity associated with light/dark cycles, compared to control. circadian rhythm behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0001712 circadian rhythm behavior variant Animals exhibit variations in the actions or reactions that recur with a periodicity associated with light/dark cycles, compared to control. GO:0048512 WB:WBPaper00032037 WB:WBPerson712 Animals exhibit variations in locomotor activity during its light/dark cycle from that observed in control animals. locomotory rhythm abnormal C_elegans_phenotype_ontology WBPhenotype:0001713 locomotory rhythm variant Animals exhibit variations in locomotor activity during its light/dark cycle from that observed in control animals. GO:0045475 WB:WBPaper00031656 WB:WBPerson712 Animals exhibit variations in turning bouts, consisting of one or more sharp turning events separating consecutive runs, which serve to orient the animal within a gradient, compared to control. pirouette abnormal C_elegans_phenotype_ontology WBPhenotype:0001714 pirouette variant Animals exhibit variations in turning bouts, consisting of one or more sharp turning events separating consecutive runs, which serve to orient the animal within a gradient, compared to control. WB:WBPaper00003740 WB:WBPaper00026967 WB:WBPerson712 Animals exhibit variations in the number of directional changes over time from that observed for control animals. frequency of directionality abnormal pirouette frequency abnormal C_elegans_phenotype_ontology WBPhenotype:0001715 pirouette frequency variant Animals exhibit variations in the number of directional changes over time from that observed for control animals. WB:WBPaper00031656 WB:WBPerson712 Animals exhibit variations in the velocity of forward translocation of any point along the animal's track from that observed for control animals. forward point velocity abnormal C_elegans_phenotype_ontology WBPhenotype:0001716 forward point velocity variant Animals exhibit variations in the velocity of forward translocation of any point along the animal's track from that observed for control animals. WB:WBPaper00024949 WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson712 Animals exhibit variations in the translocation of the mean position of the rear two-thirds (centroid position) of the animal over time, from that observed for control animals. centroid velocity abnormal C_elegans_phenotype_ontology WBPhenotype:0001717 centroid velocity variant Animals exhibit variations in the translocation of the mean position of the rear two-thirds (centroid position) of the animal over time, from that observed for control animals. WB:WBPaper00024949 WB:WBPaper00031656 WB:WBPerson712 Animals exhibit variations in the mean translocation of the points along the animal's track compared to control. instantaneous velocity abnormal C_elegans_phenotype_ontology WBPhenotype:0001718 instantaneous velocity variant Animals exhibit variations in the mean translocation of the points along the animal's track compared to control. WB:WBPaper00024949 WB:WBPerson712 Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria, compared to control. One such response is the increase in expression of chaperones. unfolded protein response abnormal C_elegans_phenotype_ontology ER unfolded protein response abnormal UPR unfolded protein response WBPhenotype:0001719 unfolded protein response variant Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria, compared to control. One such response is the increase in expression of chaperones. GO:0030968 WB:WBPaper00030877 WB:WBPaper00032003 WB:WBPerson557 WB:WBPerson712 Spermatozoa do not crawl back into the spermatheca after being swept into the uterus by passing oocytes. spermatozoa retro location abnormal C_elegans_phenotype_ontology spermatheca homing abnormal WBPhenotype:0001720 spermatozoa retro location defective Spermatozoa do not crawl back into the spermatheca after being swept into the uterus by passing oocytes. WB:WBPaper00032030 WB:WBPerson712 Animals exhibit variations in the extent of pathogen invasion into the pharynx compared to control. This is often measured as the percentage of animals exhibiting a pathogen-invaded pharynx within a given population. pathogen infected pharynx abnormal C_elegans_phenotype_ontology WBPhenotype:0001721 pathogen infected pharynx variant Animals exhibit variations in the extent of pathogen invasion into the pharynx compared to control. This is often measured as the percentage of animals exhibiting a pathogen-invaded pharynx within a given population. WB:WBPaper00032003 WB:WBPerson712 Animals exhibit a greater extent of pathogen invasion into the pharynx compared to control. C_elegans_phenotype_ontology WBPhenotype:0001722 pathogen infected pharynx increase Animals exhibit a greater extent of pathogen invasion into the pharynx compared to control. WB:WBPaper00032003 WB:WBPerson712 Animals exhibit a lesser extent of pathogen invasion into the pharynx compared to control. C_elegans_phenotype_ontology WBPhenotype:0001723 pathogen infected pharynx decrease Animals exhibit a lesser extent of pathogen invasion into the pharynx compared to control. WB:WBPaper00032003 WB:WBPerson712 Animals respond to tunicamycin at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001724 tunicamycin hypersensitive Animals respond to tunicamycin at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00030877 WB:WBPerson557 Cells exhibit variations in the response to osmotic stress compared to control. In C. elegans, exposure to stress-inducing osmotic conditions invokes cellular changes, including transcriptional up or down-regulation of genes. osmotic stress response abnormal C_elegans_phenotype_ontology WBPhenotype:0001725 cellular osmotic stress response variant Cells exhibit variations in the response to osmotic stress compared to control. In C. elegans, exposure to stress-inducing osmotic conditions invokes cellular changes, including transcriptional up or down-regulation of genes. WB:WBPaper00032031 WB:WBPerson712 Animals vary in the distance between anterior and posterior ends of the animal from that observed in control animals. body length abnormal C_elegans_phenotype_ontology WBPhenotype:0001726 body length variant Animals vary in the distance between anterior and posterior ends of the animal from that observed in control animals. WB:WBPerson712 Animals vary in the distance between dorsal and ventral sides when measured across the body at right angles to the length, from that observed in control animals. body width abnormal C_elegans_phenotype_ontology WBPhenotype:0001727 body width variant Animals vary in the distance between dorsal and ventral sides when measured across the body at right angles to the length, from that observed in control animals. WB:WBPerson712 Males differ from control animals in their ability to form copulatory plugs or their placement of these plugs. In C. elegans, males of the Hawaiian strain (CB4856) typically form mating plugs. mating plug production abnormal C_elegans_phenotype_ontology WBPhenotype:0001728 mating plug production variant Males differ from control animals in their ability to form copulatory plugs or their placement of these plugs. In C. elegans, males of the Hawaiian strain (CB4856) typically form mating plugs. WB:WBPaper00032027 WB:WBPerson712 Males form copulatory mating plugs. C_elegans_phenotype_ontology mating plug plus plug plus WBPhenotype:0001729 mating plug produced Males form copulatory mating plugs. WB:WBPaper00002770 WB:WBPerson712 Males do not form copulatory mating plug. C_elegans_phenotype_ontology mating plug minus plug minus WBPhenotype:0001730 mating plug deficient Males do not form copulatory mating plug. WB:WBPaper00002770 WB:WBPerson712 Animals exhibit variations in the duration of the trajectory of the forward track in a thermal gradient compared to control. thermal bias in tracking abnormal C_elegans_phenotype_ontology cryophilic bias WBPhenotype:0001731 thermal bias in tracking variant Animals exhibit variations in the duration of the trajectory of the forward track in a thermal gradient compared to control. WB:WBPaper00032070 WB:WBPerson712 Animals exhibit variations in their response and ability to survive over a range of pH conditions compared to control. organism response to pH abnormal C_elegans_phenotype_ontology WBPhenotype:0001732 organism response to pH variant Animals exhibit variations in their response and ability to survive over a range of pH conditions compared to control. WB:WBPaper00032033 WB:WBPerson712 Animals treated with pheromone do not exhibit a decrease in pumping rate similar to that observed for control animals. pheromone suppressed pumping abnormal C_elegans_phenotype_ontology WBPhenotype:0001733 pheromone suppressed pumping defective Animals treated with pheromone do not exhibit a decrease in pumping rate similar to that observed for control animals. WB:WBPaper00032082 WB:WBPerson712 Animals deprived of food do not exhibit a decrease in pumping rate similar to that observed for control animals. starvation suppressed pumping abnormal C_elegans_phenotype_ontology food deprived suppression of pumping abnormal WBPhenotype:0001734 starvation suppressed pumping defective Animals deprived of food do not exhibit a decrease in pumping rate similar to that observed for control animals. WB:WBPaper00032082 WB:WBPerson712 Animals exhibit variations in the frequency, rate or extent of muscle contraction compared to control animals. muscle cell activity abnormal C_elegans_phenotype_ontology WBPhenotype:0001735 muscle cell activity variant Animals exhibit variations in the frequency, rate or extent of muscle contraction compared to control animals. GO:0006937 WB:WBPaper00032000 WB:WBPerson712 Failure to execute the characteristic response to acetate compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001736 acetate chemotaxis defective Failure to execute the characteristic response to acetate compared to control animals. WB:WBPaper00031959 WB:WBPerson557 WB:WBPerson712 Animals are unable to locate the gradient peak of a water soluble compound, which was generated on a uniform concentration of another compound. aqueous compound discrimination abnormal C_elegans_phenotype_ontology WBPhenotype:0001737 aqueous compound discrimination defective Animals are unable to locate the gradient peak of a water soluble compound, which was generated on a uniform concentration of another compound. WB:WBPaper00031959 WB:WBPerson712 Failure to execute the characteristic response to ammonium compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001738 ammonium chemotaxis defective Failure to execute the characteristic response to ammonium compared to control animals. WB:WBPaper00031959 WB:WBPerson712 Any variation in an organism's decline over time from its optimal fertility and viability compared to control animals. aging abnormal C_elegans_phenotype_ontology WBPhenotype:0001739 aging variant Any variation in an organism's decline over time from its optimal fertility and viability compared to control animals. WB:WBPaper00032067 WB:WBPerson712 Any variation in the preprogrammed process that occurs in an organism that is associated with the dismantling of an organ and an overall decline in metabolic function compared to control animals. This may include variations in the rate or extent of morphological disarray and of the breakdown or organelles, membranes and other cellular components. organ senescence abnormal C_elegans_phenotype_ontology WBPhenotype:0001740 organ senescence variant Any variation in the preprogrammed process that occurs in an organism that is associated with the dismantling of an organ and an overall decline in metabolic function compared to control animals. This may include variations in the rate or extent of morphological disarray and of the breakdown or organelles, membranes and other cellular components. GO:0010260 WB:WBPaper00032067 WB:WBPerson712 Males exhibit spicule-muscle seizures leading to inappropriately timed protraction compared to control. Prc C_elegans_phenotype_ontology precocious spicule protraction protraction constitutive WBPhenotype:0001741 spontaneous spicule protraction Males exhibit spicule-muscle seizures leading to inappropriately timed protraction compared to control. WB:WBPaper00032000 WB:WBPerson712 The endogenous anabolism of any lipid species has been increased compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001742 lipid synthesis increased The endogenous anabolism of any lipid species has been increased compared to that observed in control animals. WB:WBPaper00032082 WB:WBPerson712 Any variation in the division of the eukaryotic cell nucleus to produce two daughter nuclei that contain the identical chromosome complement of their mother compared to control. mitosis abnormal C_elegans_phenotype_ontology WBPhenotype:0001743 mitosis variant Any variation in the division of the eukaryotic cell nucleus to produce two daughter nuclei that contain the identical chromosome complement of their mother compared to control. GO:0000278 WB:WBPerson557 Any variation in the attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix compared to control. cell adhesion abnormal C_elegans_phenotype_ontology WBPhenotype:0001744 cell adhesion variant Any variation in the attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix compared to control. GO:0007155 WB:WBPerson557 Any variation in a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments compared to control. adherens junction abnormal C_elegans_phenotype_ontology WBPhenotype:0001745 adherens junction variant Any variation in a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments compared to control. GO:0005912 WB:WBPerson557 Any perturbation in the belt-like region of very close contact between the plasma membranes of adjacent cells that results in the complete occlusion of the intercellular space. zonula occludens abnormal tight junction abnormal C_elegans_phenotype_ontology WBPhenotype:0001746 tight junction defective Any perturbation in the belt-like region of very close contact between the plasma membranes of adjacent cells that results in the complete occlusion of the intercellular space. GO:0005923 WB:WBPerson557 Animals exhibit variations in the change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus compared to control. zinc response abnormal C_elegans_phenotype_ontology WBPhenotype:0001747 zinc response variant Animals exhibit variations in the change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus compared to control. GO:0010043 WB:WBPerson712 The pharynx or pharyngeal muscle does not form a functional connection to the mouth or buccal cavity. Pun C_elegans_phenotype_ontology WBPhenotype:0001748 pharynx unattached The pharynx or pharyngeal muscle does not form a functional connection to the mouth or buccal cavity. WB:WBPaper00031910 WB:WBPerson712 The toxic response to zinc occurs at a lower concentration or a shorter exposure compared to control animals. In C. elegans hypersensitive animals exhibit delayed development or lethality at concentrations of zinc (e.g. ZnSO4), which has little or no effect on control worms. C_elegans_phenotype_ontology WBPhenotype:0001749 zinc toxicity hypersensitive The toxic response to zinc occurs at a lower concentration or a shorter exposure compared to control animals. In C. elegans hypersensitive animals exhibit delayed development or lethality at concentrations of zinc (e.g. ZnSO4), which has little or no effect on control worms. WB:WBPaper00031911 WB:WBPerson712 Animals fail to exhibit toxicity to the concentration of zinc that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans toxic responses to zinc include delayed development or lethality. C_elegans_phenotype_ontology WBPhenotype:0001750 zinc toxicity resistant Animals fail to exhibit toxicity to the concentration of zinc that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans toxic responses to zinc include delayed development or lethality. WB:WBPaper00031911 WB:WBPerson712 Animals exhibit increased lethality as a result of exposure to environments with a higher solute concentration than their own internal environment, compared to control. C_elegans_phenotype_ontology Hos hypertonic sensitive WBPhenotype:0001751 organism hypertonic lethality increased Animals exhibit increased lethality as a result of exposure to environments with a higher solute concentration than their own internal environment, compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in vesicle-based directed movement of substances into, out of, or within a cell compared to control. vesicle trafficking abnormal C_elegans_phenotype_ontology WBPhenotype:0001752 vesicle trafficking variant Animals exhibit variations in vesicle-based directed movement of substances into, out of, or within a cell compared to control. GO:0016192 WB:WBPerson712 Animals exhibit intensified accumulation of fluids or fluorescent markers etc. within their coelomocytes compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001753 coelomocyte uptake increased Animals exhibit intensified accumulation of fluids or fluorescent markers etc. within their coelomocytes compared to control animals. WB:WBPaper00004883 WB:WBPerson712 Contents of endosomes fail to be transported to lysosomal compartments. C_elegans_phenotype_ontology WBPhenotype:0001754 endosome to lysosome trafficking defective Contents of endosomes fail to be transported to lysosomal compartments. WB:WBPaper00029049 WB:WBPerson712 Animals do not arrest mitotic germ cell division, as control animals, when treated with UV radiation. C_elegans_phenotype_ontology WBPhenotype:0001755 UV induced mitotic germ cell arrest defective Animals do not arrest mitotic germ cell division, as control animals, when treated with UV radiation. WB:WBPaper00028948 WB:WBPerson557 Programmed cell death caused by UV radiation is reduced compared to control animals. In C. elegans, this is often measured in the pachytene region of the gonad. C_elegans_phenotype_ontology WBPhenotype:0001756 UV induced apoptosis decreased Programmed cell death caused by UV radiation is reduced compared to control animals. In C. elegans, this is often measured in the pachytene region of the gonad. WB:WBPaper00028948 WB:WBPerson557 Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of signalling peptides in the organism compared to control. neuropeptide metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0001757 neuropeptide metabolism variant Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of signalling peptides in the organism compared to control. WB:WBPerson712 Variations in the chemical reactions and pathways involved in the formation and maturation of specialized peptidergic neurotransmitters encoded as preproproteins that are posttranslationally processed to yield bioactive neuropeptides compared to control (Wormatlas). neuropeptide processing abnormal C_elegans_phenotype_ontology WBPhenotype:0001758 neuropeptide processing variant Variations in the chemical reactions and pathways involved in the formation and maturation of specialized peptidergic neurotransmitters encoded as preproproteins that are posttranslationally processed to yield bioactive neuropeptides compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the biogenesis or stability of the 21U-RNA class of molecules compared to control. Molecules are classified as 21U-RNA based on the presence of a 5'U and a conserved upstream motif, which may specify the production of these molecules, in addition these molecules are typically 21nt in length. 21U RNA expression abnormal C_elegans_phenotype_ontology piRNA expression abnormal WBPhenotype:0001759 21U RNA expression variant Variations in the biogenesis or stability of the 21U-RNA class of molecules compared to control. Molecules are classified as 21U-RNA based on the presence of a 5'U and a conserved upstream motif, which may specify the production of these molecules, in addition these molecules are typically 21nt in length. GO:0016070 WB:WBPaper00028915 WB:WBPaper00031962 WB:WBPerson712 Animals exhibit an increase in the rate of deletion events in mono-G or G-rich tracts within the genome compared to control. C_elegans_phenotype_ontology WBPhenotype:0001760 G tract instability Animals exhibit an increase in the rate of deletion events in mono-G or G-rich tracts within the genome compared to control. WB:WBPaper00031945 WB:WBPerson712 Regulated ventral midline crossing by axons vary either in the frequency of crossing events or the maintenance through development of process positions compared to control. axon midline crossing abnormal C_elegans_phenotype_ontology WBPhenotype:0001761 axon midline crossing variant Regulated ventral midline crossing by axons vary either in the frequency of crossing events or the maintenance through development of process positions compared to control. GO:0016199 WB:WBPaper00032007 WB:WBPerson712 Yolk is not taken up by oocytes in the same manner or to the same degree as observed for control animals. This often leads to an accumulation of yolk in the pseudocoelom. C_elegans_phenotype_ontology WBPhenotype:0001762 uptake of yolk defective Yolk is not taken up by oocytes in the same manner or to the same degree as observed for control animals. This often leads to an accumulation of yolk in the pseudocoelom. WB:WBPaper00003831 WB:WBPerson712 Uptake of subtances from the intestine is altered from that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001763 uptake by intestinal cell defective Uptake of subtances from the intestine is altered from that observed in control animals. WB:WBPaper00004883 WB:WBPerson712 Animals exhibit variations in their response to carbon dioxide compared to control. carbon dioxide response abnormal C_elegans_phenotype_ontology WBPhenotype:0001764 carbon dioxide response variant Animals exhibit variations in their response to carbon dioxide compared to control. WB:WBPerson712 Variations in the characteristic movement away from specific CO2 levels compared to control. C. elegans avoids high levels of CO2. carbon dioxide avoidance abnormal C_elegans_phenotype_ontology CO2 avoidance abnormal Cdad WBPhenotype:0001765 carbon dioxide avoidance variant Variations in the characteristic movement away from specific CO2 levels compared to control. C. elegans avoids high levels of CO2. WB:WBPaper00031935 WB:WBPerson557 WB:WBPerson712 Animals are more sensitive to the reduction of cholesterol in the environment compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001766 cholesterol depletion hypersensitive Animals are more sensitive to the reduction of cholesterol in the environment compared to control animals. GO:0042632 WB:WBPaper00026641 WB:WBPerson557 WB:WBPerson712 Outgrowth of the commissure occurs on the side of the body different from that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001767 commissure handedness defective Outgrowth of the commissure occurs on the side of the body different from that observed in control animals. WB:WBPaper00032007 WB:WBPerson712 Variations in the quantity of circumferential axonal tracts from the number observed in control animals. commissure number abnormal C_elegans_phenotype_ontology WBPhenotype:0001768 commissure number variant Variations in the quantity of circumferential axonal tracts from the number observed in control animals. WB:WBPaper00032007 WB:WBPerson712 Animals fail to silence cytoplasmic-localized RNAs. Nuclear-localized RNAs may still be sensitive to RNAi. C_elegans_phenotype_ontology WBPhenotype:0001769 cytoplasmic RNAi defective Animals fail to silence cytoplasmic-localized RNAs. Nuclear-localized RNAs may still be sensitive to RNAi. WB:WBPaper00032049 WB:WBPerson712 Animals exhibit variations in their selective interactions with small interfering RNA molecules compared to control. endo siRNA binding abnormal C_elegans_phenotype_ontology WBPhenotype:0001770 endo siRNA binding variant Animals exhibit variations in their selective interactions with small interfering RNA molecules compared to control. GO:0035197 WB:WBPaper00032049 WB:WBPerson712 Animals exhibit variations in the length or amount of any endogenous small interfering RNA molecule populations compared to control. endo siRNA production abnormal C_elegans_phenotype_ontology WBPhenotype:0001771 endo siRNA production variant Animals exhibit variations in the length or amount of any endogenous small interfering RNA molecule populations compared to control. WB:WBPaper00031932 WB:WBPaper00032049 WB:WBPerson712 Animals exhibit an increase in the levels of transposase mRNA, from endogenous transposons, over that measured in control animals. C_elegans_phenotype_ontology WBPhenotype:0001772 endogenous transposase levels increased Animals exhibit an increase in the levels of transposase mRNA, from endogenous transposons, over that measured in control animals. WB:WBPaper00031962 WB:WBPerson712 Animals do not exhibit an increase in speed when placed in an environment that relies on a combination of swimming and crawling behaviors compared to control. C_elegans_phenotype_ontology WBPhenotype:0001773 enhanced locomotion defective Animals do not exhibit an increase in speed when placed in an environment that relies on a combination of swimming and crawling behaviors compared to control. WB:WBPaper00031965 WB:WBPerson712 An epidermal enclosure defect that results in internal organs lying on the outside of the embryo. Gex C_elegans_phenotype_ontology WBPhenotype:0001774 gut on the exterior An epidermal enclosure defect that results in internal organs lying on the outside of the embryo. WB:WBPaper00005123 WB:WBPaper00032090 WB:WBPerson712 Pre-treatment with stress-inducing temperatures does not result in a life-span extension as it does in control animals. C_elegans_phenotype_ontology WBPhenotype:0001775 hormetic temperature induced life span extension defective Pre-treatment with stress-inducing temperatures does not result in a life-span extension as it does in control animals. WB:WBPaper00028750 WB:WBPaper00031942 WB:WBPerson712 Variations in the biogenesis and stability of the small interfering class of RNA molecules compared to control. In C. elegans these molecules are antisense to mRNA's and may be processed from long double-stranded RNA. siRNA expression abnormal C_elegans_phenotype_ontology WBPhenotype:0001776 siRNA expression variant Variations in the biogenesis and stability of the small interfering class of RNA molecules compared to control. In C. elegans these molecules are antisense to mRNA's and may be processed from long double-stranded RNA. GO:0016070 WB:WBPaper00028915 WB:WBPaper00031962 WB:WBPerson712 Animals exhibit an increase in the levels of nuclear mRNA species compared to control. C_elegans_phenotype_ontology WBPhenotype:0001777 pre mRNA levels increased Animals exhibit an increase in the levels of nuclear mRNA species compared to control. WB:WBPaper00032049 WB:WBPerson712 Animals fail to silence nuclear-localized RNAs. Animals still retain sensitivity to RNAi for those RNAs located outside of the nucleus. C_elegans_phenotype_ontology WBPhenotype:0001778 nuclear RNAi defective Animals fail to silence nuclear-localized RNAs. Animals still retain sensitivity to RNAi for those RNAs located outside of the nucleus. WB:WBPaper00032049 WB:WBPerson712 Variations in the biogenesis or stability of the microRNA class of molecules compared to control. In C. elegans these molecules are endogenous single-stranded regulatory molecules, 19-25 nucleotides long, with the potential to arise from hairpin, foldback, structures from their primary transcripts. miRNA expression abnormal C_elegans_phenotype_ontology WBPhenotype:0001779 miRNA expression variant Variations in the biogenesis or stability of the microRNA class of molecules compared to control. In C. elegans these molecules are endogenous single-stranded regulatory molecules, 19-25 nucleotides long, with the potential to arise from hairpin, foldback, structures from their primary transcripts. GO:0035196 WB:WBPaper00028915 WB:WBPaper00029181 WB:WBPaper00030747 WB:WBPaper00031962 WB:WBPerson712 Variations in the behavioral plasticity induced by the integration of two sensory signals compared to control. In C. elegans animals exhibit enhancement of butanone chemotaxis by preexposure to butanone and food. C_elegans_phenotype_ontology WBPhenotype:0001780 associative learning variant Variations in the behavioral plasticity induced by the integration of two sensory signals compared to control. In C. elegans animals exhibit enhancement of butanone chemotaxis by preexposure to butanone and food. WB:WBPaper00029060 WB:WBPerson2021 Animals are more susceptible than control animals to the effects of a nucleic acid damaging agent. This increased susceptibility is often measured by an increase in the rate of spontaneous mutations or an increased lethality. C_elegans_phenotype_ontology WBPhenotype:0001781 hypersensitivity to mutagen Animals are more susceptible than control animals to the effects of a nucleic acid damaging agent. This increased susceptibility is often measured by an increase in the rate of spontaneous mutations or an increased lethality. WB:WBPaper00031945 WB:WBPerson712 Response to trace levels of oxygen is reduced or weakened compared to the response of control animals. C_elegans_phenotype_ontology WBPhenotype:0001782 anoxia response attenuated Response to trace levels of oxygen is reduced or weakened compared to the response of control animals. WB:WBPaper00031981 WB:WBPerson712 Animals exhibit variations in the actions of a channel that catalyses the transmembrane transfer of a cation when acetylcholine has been bound by the channel complex or one of its constituent parts compared to control animals. ligand gated channel activity abnormal C_elegans_phenotype_ontology WBPhenotype:0001783 ligand gated channel activity variant Animals exhibit variations in the actions of a channel that catalyses the transmembrane transfer of a cation when acetylcholine has been bound by the channel complex or one of its constituent parts compared to control animals. GO:0022834 WB:WBPaper00031930 WB:WBPerson712 OBSOLETE: Animals are deficient in the formation or disassembly of lysosomes. C_elegans_phenotype_ontology WBPhenotype:0001784 obsolete lysosome homeostasis deficient true OBSOLETE: Animals are deficient in the formation or disassembly of lysosomes. GO:0007040 WB:WBPaper00029049 WB:WBPerson712 Animals are deficient in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms. C_elegans_phenotype_ontology WBPhenotype:0001785 associative memory defective Animals are deficient in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms. WB:WBPaper00031974 WB:WBPerson712 Animals exhibit variations in the targeting, clustering and or maintenance of ion channels in distinct subcellular domains of the neuron compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001786 neuronal ion channel clustering defective Animals exhibit variations in the targeting, clustering and or maintenance of ion channels in distinct subcellular domains of the neuron compared to control animals. GO:0045161 WB:WBPaper00031930 WB:WBPerson712 Animals do not respond via directed movement to light stimuli in the same manner as control animals. In C. elegans, animals move away from light. C_elegans_phenotype_ontology WBPhenotype:0001787 phototaxis defective Animals do not respond via directed movement to light stimuli in the same manner as control animals. In C. elegans, animals move away from light. WB:WBPaper00031999 WB:WBPerson712 Animals survive longer than control animals after or during exposure to DNA damaging agents. C_elegans_phenotype_ontology WBPhenotype:0001788 resistant to mutagens Animals survive longer than control animals after or during exposure to DNA damaging agents. WB:WBPaper00031934 WB:WBPerson712 Life span of the animal is not influenced by changes in temperature in the same manner as control animals. temperature independent life span temperature influenced life span abnormal C_elegans_phenotype_ontology WBPhenotype:0001789 temperature influenced life span variant Life span of the animal is not influenced by changes in temperature in the same manner as control animals. WB:WBPaper00031942 WB:WBPerson712 Cooling or warming evoked changes in membrane currents are not observed. C_elegans_phenotype_ontology ThRC absent WBPhenotype:0001790 thermoreceptor currents absent Cooling or warming evoked changes in membrane currents are not observed. WB:WBPaper00032060 WB:WBPerson712 Animals exhibit variations in temperature dependent differences in the length of their defecation cycle. In C. elegans the length of the cycle is the same at different temperatures, showing temperature compensation. defecation cycle temperature compensation abnormal C_elegans_phenotype_ontology WBPhenotype:0001791 defecation cycle temperature compensation variant Animals exhibit variations in temperature dependent differences in the length of their defecation cycle. In C. elegans the length of the cycle is the same at different temperatures, showing temperature compensation. WB:WBPaper00002315 WB:WBPerson712 Nuclei of specific cells are smaller compared to control animals. nuclear size decreased C_elegans_phenotype_ontology WBPhenotype:0001792 nuclei small Nuclei of specific cells are smaller compared to control animals. WB:WBPerson557 The anterior body contraction and expulsion steps of the defecation cycle are absent; posterior body contractions are still present. C_elegans_phenotype_ontology Aex WBPhenotype:0001793 aboc expulsion missing The anterior body contraction and expulsion steps of the defecation cycle are absent; posterior body contractions are still present. WB:WBPaper00002776 WB:WBPerson712 Discrete foci within the cytoplasm containing congregations of mRNA translational suppression and degradation mechanisms vary in their arrangement, clustering or are otherwise not well-defined compared to control. cytoplasmic processing body abnormal C_elegans_phenotype_ontology P body abnormal WBPhenotype:0001794 cytoplasmic processing body variant Discrete foci within the cytoplasm containing congregations of mRNA translational suppression and degradation mechanisms vary in their arrangement, clustering or are otherwise not well-defined compared to control. WB:WBPaper00031914 WB:WBPaper00032172 WB:WBPerson712 Animals exhibit variations in repeat lengths of microsatellite genomic sequences compared to control. C_elegans_phenotype_ontology WBPhenotype:0001795 microsatellite instability Animals exhibit variations in repeat lengths of microsatellite genomic sequences compared to control. WB:WBPaper00031859 WB:WBPerson712 Animals exhibit increased sensitivity to interstrand cross-linking agents, such as HN2 (nitrogen mustard) and CDDP (cisplatin) compared to control. In C. elegans, increased sensitivity to these agents is often observed as a decrease in survival compared to control animals after exposure to the agent. C_elegans_phenotype_ontology interstrand cross link agent hypersensitive WBPhenotype:0001796 organism hypersensitive interstrand cross link agents Animals exhibit increased sensitivity to interstrand cross-linking agents, such as HN2 (nitrogen mustard) and CDDP (cisplatin) compared to control. In C. elegans, increased sensitivity to these agents is often observed as a decrease in survival compared to control animals after exposure to the agent. WB:WBPaper00031868 WB:WBPerson712 Germline nuclei do not progress through pachytene to diplotene. C_elegans_phenotype_ontology WBPhenotype:0001797 pachytene arrested germline nuclei Germline nuclei do not progress through pachytene to diplotene. WB:WBPaper00031914 WB:WBPerson712 The processes that inhibit the location or frequency of formation of synapses are downregulated resulting in the formation of synapses or synapse-like structures in areas of the neuron that are typically devoid of synapses in control animals. C_elegans_phenotype_ontology WBPhenotype:0001798 inhibition of synaptogenesis defective The processes that inhibit the location or frequency of formation of synapses are downregulated resulting in the formation of synapses or synapse-like structures in areas of the neuron that are typically devoid of synapses in control animals. GO:0051964 WB:WBPaper00032163 WB:WBPerson712 The processes that inhibit the location or frequency of formation of synapses are upregulated compared to control. C_elegans_phenotype_ontology WBPhenotype:0001799 inhibition of synaptogenesis hyperactive The processes that inhibit the location or frequency of formation of synapses are upregulated compared to control. GO:0051964 WB:WBPaper00032163 WB:WBPerson712 Changes in the levels of innate immune gene products in response to pathogen exposure are significantly different from that observed in control animals. antimicrobial gene expression abnormal C_elegans_phenotype_ontology WBPhenotype:0001800 pathogen induced antimicrobial gene expression variant Changes in the levels of innate immune gene products in response to pathogen exposure are significantly different from that observed in control animals. WB:WBPaper00031865 WB:WBPerson712 Animals fail to establish or maintain characteristics that delineate the dendrite from the axon. The exclusion of presynaptic components from the dendrite is one indication of axodendritic polarity. axodendritic polarity abnormal C_elegans_phenotype_ontology WBPhenotype:0001801 axodendritic polarity variant Animals fail to establish or maintain characteristics that delineate the dendrite from the axon. The exclusion of presynaptic components from the dendrite is one indication of axodendritic polarity. WB:WBPaper00032163 WB:WBPerson712 Animals fail to relax their body wall muscles to the same extent as muscles in control animals. C_elegans_phenotype_ontology WBPhenotype:0001802 body wall muscle relaxation defective Animals fail to relax their body wall muscles to the same extent as muscles in control animals. WB:WBPaper00032190 WB:WBPerson712 Animals exhibit variations in the formation or disassembly of membrane bound organelles that traffic material between the plasma membrane and internal compartments of the cell, compared to control. endosome biogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0001803 endosome biogenesis variant Animals exhibit variations in the formation or disassembly of membrane bound organelles that traffic material between the plasma membrane and internal compartments of the cell, compared to control. WB:WBPaper00032168 WB:WBPerson712 Animals exhibit a decrease in the number of fat containing organelles compared to control. In C. elegans this number can be assayed by decreases in the number of Nile Red or BODIPY 493/503 staining bodies. C_elegans_phenotype_ontology lipid body number reduced WBPhenotype:0001804 fat associated bodies reduced Animals exhibit a decrease in the number of fat containing organelles compared to control. In C. elegans this number can be assayed by decreases in the number of Nile Red or BODIPY 493/503 staining bodies. WB:WBPaper00032168 WB:WBPerson712 Inner membrane of mitochondria are disconnected and form vesicular bodies. C_elegans_phenotype_ontology WBPhenotype:0001805 mitochondria vesiculated Inner membrane of mitochondria are disconnected and form vesicular bodies. GO:0007005 WB:WBPaper00032231 WB:WBPerson712 Any variation in the ability of a protein to resist disintegration via chemical or physical modifications compared to control. protein stabilization abnormal C_elegans_phenotype_ontology WBPhenotype:0001806 protein stabilization variant Any variation in the ability of a protein to resist disintegration via chemical or physical modifications compared to control. WB:WBPaper00029085 WB:WBPerson2021 Any variation in the process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition compared to control. alternative splicing abnormal C_elegans_phenotype_ontology WBPhenotype:0001807 alternative splicing variant Any variation in the process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition compared to control. GO:0000380 WB:WBPerson557 The degradation of genomic and or cellular material of the corpse does not occur at the same rate or under the same conditions as observed in control animals undergoing cell death. cell corpse digestion abnormal C_elegans_phenotype_ontology WBPhenotype:0001808 cell corpse digestion variant The degradation of genomic and or cellular material of the corpse does not occur at the same rate or under the same conditions as observed in control animals undergoing cell death. WB:WBPaper00032272 WB:WBPerson712 The formation of mature intracellular compartments via membrane fusion is disrupted. C_elegans_phenotype_ontology WBPhenotype:0001809 organelle fusion defective The formation of mature intracellular compartments via membrane fusion is disrupted. WB:WBPaper00032272 WB:WBPerson712 Animals exhibit variations in the partitioning of oocytes from each other compared to control animals. oocyte septum formation abnormal C_elegans_phenotype_ontology oocyte cellularization defective oocyte partition variant WBPhenotype:0001810 oocyte septum formation variant Animals exhibit variations in the partitioning of oocytes from each other compared to control animals. WB:WBPaper00028947 Animals retain a significantly greater proportion of their fat upon serotonin treatment, compared to control. serotonin induced fat reduction abnormal C_elegans_phenotype_ontology serotonin induced fat regulation WBPhenotype:0001811 serotonin induced fat reduction variant Animals retain a significantly greater proportion of their fat upon serotonin treatment, compared to control. WB:WBPaper00031915 WB:WBPerson2021 During development of the embryo, the epidermis loses integrity and the contents of the embryo are expelled. C_elegans_phenotype_ontology WBPhenotype:0001812 embryonic rupture During development of the embryo, the epidermis loses integrity and the contents of the embryo are expelled. WB:WBPerson557 Animals exhibit defects in the stabilization of homologue pairing, which occurs through the initiation and formation of the synaptonemal complex, during meiosis. C_elegans_phenotype_ontology WBPhenotype:0001813 synapsis defective Animals exhibit defects in the stabilization of homologue pairing, which occurs through the initiation and formation of the synaptonemal complex, during meiosis. WB:WBPaper00032296 WB:WBPerson712 Animals exhibit defects in the number or extent of connections between chromatids that occur during the process of genetic material exchange between homologous segments of non-sister chromatids. C_elegans_phenotype_ontology chiasma defective homologous recombination foci variant WBPhenotype:0001814 crossover defective Animals exhibit defects in the number or extent of connections between chromatids that occur during the process of genetic material exchange between homologous segments of non-sister chromatids. GO:0051026 WB:WBPaper00032296 WB:WBPerson712 Animals exhibit defects in the asymmetric diassembly of the synaptonemal complex during progression through meiosis. C_elegans_phenotype_ontology WBPhenotype:0001815 desynapsis defective Animals exhibit defects in the asymmetric diassembly of the synaptonemal complex during progression through meiosis. WB:WBPaper00032296 WB:WBPerson712 Neuromuscular signaling between neurons and egg laying musculature varies from that observed for control animals. egg laying circuit abnormal C_elegans_phenotype_ontology WBPhenotype:0001816 egg laying circuit variant Neuromuscular signaling between neurons and egg laying musculature varies from that observed for control animals. WB:WBPaper00032221 WB:WBPerson712 The conditioned aversion to a specific chemical compound as a result of that compound being coupled with an unfavorable condition, such as starvation, does not increase to the same extent as observed for control animals. C_elegans_phenotype_ontology enhanced gustatory plasticity defective enhanced taste aversion defective starvation enhanced taste aversion defective WBPhenotype:0001817 enhanced taste aversion defective The conditioned aversion to a specific chemical compound as a result of that compound being coupled with an unfavorable condition, such as starvation, does not increase to the same extent as observed for control animals. WB:WBPaper00032335 WB:WBPerson712 Activity of the neuron varies from that observed for control animals or neurons. In C. elegans neuron activity is often assayed by observing calcium spikes. neuron activation abnormal C_elegans_phenotype_ontology neuron activity abnormal WBPhenotype:0001818 neuron activation variant Activity of the neuron varies from that observed for control animals or neurons. In C. elegans neuron activity is often assayed by observing calcium spikes. WB:WBPaper00032221 WB:WBPerson712 The number of pathogens associated with the animal vary from that associated with control animals. bacterial load variant C_elegans_phenotype_ontology WBPhenotype:0001819 pathogen load variant The number of pathogens associated with the animal vary from that associated with control animals. WB:WBPaper00032196 WB:WBPerson712 Animals tend to accumulate at the thickest part of the bacterial lawn. C_elegans_phenotype_ontology bordering increased WBPhenotype:0001820 bordering Animals tend to accumulate at the thickest part of the bacterial lawn. WB:WBPaper00003187 WB:WBPaper00032342 WB:WBPerson712 Animals do not accumulate at the thickest part of the bacterial lawn. Animals do not preferentially deplete bacterial food at the thicker parts of the lawn. C_elegans_phenotype_ontology WBPhenotype:0001821 non bordering Animals do not accumulate at the thickest part of the bacterial lawn. Animals do not preferentially deplete bacterial food at the thicker parts of the lawn. WB:WBPaper00032342 WB:WBPerson712 Animals produce pheromone but it does not undergo controlled release into the environment. C_elegans_phenotype_ontology WBPhenotype:0001822 dauer pheromone secretion variant Animals produce pheromone but it does not undergo controlled release into the environment. WB:WBPaper00032517 WB:WBPerson712 Any variation in the mechanism by which sperm find their correct target destinations (spermatheca). C_elegans_phenotype_ontology WBPhenotype:0001823 sperm recruitment variant Any variation in the mechanism by which sperm find their correct target destinations (spermatheca). WB:WBPaper00028527 WB:WBPerson2021 Animals exhibit variations in any process necessary for the progression through prophase during meiosis compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001824 meiotic progression prophase variant Animals exhibit variations in any process necessary for the progression through prophase during meiosis compared to control animals. WB:WBPaper00005486 WB:WBPerson557 Animals have very few or no germline nuclei and gonad arms that are very small or missing. C_elegans_phenotype_ontology WBPhenotype:0001825 rudimentary gonad Animals have very few or no germline nuclei and gonad arms that are very small or missing. WB:WBPaper00005486 WB:WBPerson557 Variations in the regulated breakdown of RNA species via the action of cellular enzymes (RNases) compared to control. C_elegans_phenotype_ontology WBPhenotype:0001826 RNA degradation variant Variations in the regulated breakdown of RNA species via the action of cellular enzymes (RNases) compared to control. WB:WBPaper00032091 WB:WBPerson2021 Variations in any process that involves the maintenance, biosynthesis or accumulation of RNA in the organism compared to control. C_elegans_phenotype_ontology WBPhenotype:0001827 RNA metabolism variant Variations in any process that involves the maintenance, biosynthesis or accumulation of RNA in the organism compared to control. WB:WBPaper00004325 WB:WBPerson2021 Variations in the persistence of an RNAi induced phenotype compared to control. C_elegans_phenotype_ontology WBPhenotype:0001828 RNAi persistence variant Variations in the persistence of an RNAi induced phenotype compared to control. WB:WBPaper00004325 WB:WBPerson2021 Any variation that results in the premature differentiation of spermatids into motile spermatozoa compared to control. C_elegans_phenotype_ontology WBPhenotype:0001829 premature spermatid activation Any variation that results in the premature differentiation of spermatids into motile spermatozoa compared to control. WB:WBPaper00033007 WB:WBPerson2021 Any variation in an animal's response to exposure to multiple stressors occuring simultaneously or during an overlapping temporal window compared to control. C_elegans_phenotype_ontology WBPhenotype:0001830 response to multiple stressors variant Any variation in an animal's response to exposure to multiple stressors occuring simultaneously or during an overlapping temporal window compared to control. WB:WBPaper00031874 WB:WBPerson2021 Any variation in the formation of intestinal microvilli. Microvilli are actin-based cellular structures that form plasma membrane projections into the extracellular space and whose specialized shape provides increased cellular surface area. Microvilli are a crucial component of the terminal differentiation process for many epithelial cell types, usually ones that play an absorptive or filtering role. C_elegans_phenotype_ontology WBPhenotype:0001831 intestinal microvilli variant Any variation in the formation of intestinal microvilli. Microvilli are actin-based cellular structures that form plasma membrane projections into the extracellular space and whose specialized shape provides increased cellular surface area. Microvilli are a crucial component of the terminal differentiation process for many epithelial cell types, usually ones that play an absorptive or filtering role. WB:WBPaper00025171 WB:WBPerson557 Any variation that disrupts the assembly, distribution, localization or organization of any of the numerous similar discrete openings in the nuclear envelope, where the inner and outer nuclear membranes are joined. C_elegans_phenotype_ontology WBPhenotype:0001832 nuclear pore variant Any variation that disrupts the assembly, distribution, localization or organization of any of the numerous similar discrete openings in the nuclear envelope, where the inner and outer nuclear membranes are joined. GO:0005643 WB:WBPerson557 Any variation in the directed movement of substances in a cell, from one side of a membrane to another, compared to control. C_elegans_phenotype_ontology membrane transport variant transporter activity variant WBPhenotype:0001833 membrane trafficking variant Any variation in the directed movement of substances in a cell, from one side of a membrane to another, compared to control. GO:0005215 WB:WBPaper00025137 WB:WBPerson2021 Variations in the processes regulating the excision of intervening introns from the primary mRNA transcript, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001834 mRNA splicing variant Variations in the processes regulating the excision of intervening introns from the primary mRNA transcript, compared to control. GO:0008380 WB:WBPaper00032287 WB:WBPerson2021 Variations in the amount of energy consumed by an organism compared to control. Energy expenditure is often determined by assaying oxygen consumption. C_elegans_phenotype_ontology WBPhenotype:0001835 energy expenditure variant Variations in the amount of energy consumed by an organism compared to control. Energy expenditure is often determined by assaying oxygen consumption. WB:WBPaper00032936 WB:WBPerson2021 Any variation in the overall structure or appearance of the protective barrier which isolates the embryo from the external environment, compared to control . C_elegans_phenotype_ontology WBPhenotype:0001836 eggshell morphology variant Any variation in the overall structure or appearance of the protective barrier which isolates the embryo from the external environment, compared to control . WB:WBPaper00033072 WB:WBPerson2021 Life span of the animal is not influenced by changes in diet in the same manner as control animals. C_elegans_phenotype_ontology WBPhenotype:0001837 diet induced life span variant Life span of the animal is not influenced by changes in diet in the same manner as control animals. WB:WBPaper00032936 WB:WBPerson2021 Gene expression of an animal is not influenced by drug treatment in the same manner as control animals. C_elegans_phenotype_ontology WBPhenotype:0001838 drug induced gene expression variant Gene expression of an animal is not influenced by drug treatment in the same manner as control animals. WB:WBPaper00033094 WB:WBPerson2021 Animals fail to respond to the concentration of phorbol esters that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Phorbol esters such as PMA act as DAG mimetics. C_elegans_phenotype_ontology WBPhenotype:0001839 phorbol ester resistant Animals fail to respond to the concentration of phorbol esters that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Phorbol esters such as PMA act as DAG mimetics. WB:WBPaper00033094 WB:WBPerson2021 Variations in the processes that restore integrity to a damaged tissue following an injury, compared to control. C_elegans_phenotype_ontology wound healing variant WBPhenotype:0001840 response to injury variant Variations in the processes that restore integrity to a damaged tissue following an injury, compared to control. GO:0042060 WB:WBPaper00033094 WB:WBPerson2021 Any variation in a series of molecular signals that help relay a receptor mediated signal within the cell, compared to control. Second messengers often comprise of ions (eg: Ca2+) or small molecules (cGMP, cAMP etc) that are formed or released into the cytosol. C_elegans_phenotype_ontology WBPhenotype:0001841 second messenger mediated signaling variant Any variation in a series of molecular signals that help relay a receptor mediated signal within the cell, compared to control. Second messengers often comprise of ions (eg: Ca2+) or small molecules (cGMP, cAMP etc) that are formed or released into the cytosol. GO:0019932 WB:WBPaper00033456 WB:WBPerson2021 Any variation in the state or activity of an organism as a result of abrupt discontinuation or decreased dosage of a drug, compared to control. C_elegans_phenotype_ontology rebound response defective WBPhenotype:0001842 drug withdrawal response variant Any variation in the state or activity of an organism as a result of abrupt discontinuation or decreased dosage of a drug, compared to control. WB:WBPaper00033168 WB:WBPerson2021 Animals exhibit variations in any process that involves the degradation, biosynthesis or accumulation of hormones within the organism compared to control. Hormones are naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. C_elegans_phenotype_ontology WBPhenotype:0001843 hormone metabolism variant Animals exhibit variations in any process that involves the degradation, biosynthesis or accumulation of hormones within the organism compared to control. Hormones are naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. GO:0042445 WB:WBPaper00034639 WB:WBPerson2021 Variations in the process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids, compared to control. C_elegans_phenotype_ontology fat granule regulated breakdown variant fat granule regulated hydrolysis variant lipid lysis regulation variant regulation of lipid catabolic process variant WBPhenotype:0001844 lipid hydrolysis regulation variant Variations in the process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids, compared to control. GO:0050994 WB:WBPaper00033126 WB:WBPerson2021 Variations in the covalent alteration of one or more components (eg: fatty acids, sterols etc.) in a lipid, resulting in a change in the properties of the lipid, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001845 lipid modification variant Variations in the covalent alteration of one or more components (eg: fatty acids, sterols etc.) in a lipid, resulting in a change in the properties of the lipid, compared to control. GO:0030258 WB:WBPaper00034639 WB:WBPerson2021 Early phagosomes fail to undergo the maturation process following the ingestion of particulate material by phagocytosis; During maturation, phagosomes acquire markers of late endosomes and lysosomes. C_elegans_phenotype_ontology WBPhenotype:0001846 phagosome maturation defective Early phagosomes fail to undergo the maturation process following the ingestion of particulate material by phagocytosis; During maturation, phagosomes acquire markers of late endosomes and lysosomes. GO:0001845 WB:WBPaper00031805 WB:WBPerson2021 Variations in the processes that facilitate/permit dauer entry when exposed to specific sterol molecules, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001847 sterol induced dauer formation variant Variations in the processes that facilitate/permit dauer entry when exposed to specific sterol molecules, compared to control. WB:WBPaper00034639 WB:WBPerson2021 Variations in the process by which the anatomical structures of a tube are generated and organized, compared to control. Morphogenesis pertains to the creation of form or shape. C_elegans_phenotype_ontology tubulogenesis variant WBPhenotype:0001848 tube morphogenesis variant Variations in the process by which the anatomical structures of a tube are generated and organized, compared to control. Morphogenesis pertains to the creation of form or shape. GO:0035239 WB:WBPaper00033081 WB:WBPerson2021 Variations in the regulation of levels, transport, and metabolism of zinc ions within an organism compared to control. C_elegans_phenotype_ontology WBPhenotype:0001849 zinc homeostasis variant Variations in the regulation of levels, transport, and metabolism of zinc ions within an organism compared to control. GO:0006882 WB:WBPaper00033166 WB:WBPerson2021 Programmed cell death of germ cells caused by exposure to ionizing energy does not occur to the same extent as it does in control animals. C_elegans_phenotype_ontology WBPhenotype:0001850 radiation induced germ cell apoptosis variant Programmed cell death of germ cells caused by exposure to ionizing energy does not occur to the same extent as it does in control animals. WB:WBPaper00032243 WB:WBPaper00032356 WB:WBPerson712 Animals exhibit variations in radiation induced non-apoptotic death of multipotential precursor cells or tissues (clonogens) compared to control. Elimination of clonogens results in normal tissue damage as well as solid-tumor eradication. C_elegans_phenotype_ontology WBPhenotype:0001851 radiation induced reproductive cell death variant Animals exhibit variations in radiation induced non-apoptotic death of multipotential precursor cells or tissues (clonogens) compared to control. Elimination of clonogens results in normal tissue damage as well as solid-tumor eradication. WB:WBPaper00027700 WB:WBPerson2021 Animals exhibit variations in their response to an agent that destroys or causes the expulsion of parasitic intestinal worms compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001852 antihelmintic response variant Animals exhibit variations in their response to an agent that destroys or causes the expulsion of parasitic intestinal worms compared to that observed in control animals. WB:WBPaper00035074 WB:WBPerson2021 Animals exhibit variations in their response to the amino-acetonitrile derivatives (AADs) class of synthetic anthelmintics, compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001853 AAD response variant Animals exhibit variations in their response to the amino-acetonitrile derivatives (AADs) class of synthetic anthelmintics, compared to that observed in control animals. WB:WBPaper00035150 WB:WBPerson2021 Animals exhibit variations in their response to the microtubule-depolymerizing drug benomyl, compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001854 benomyl response variant Animals exhibit variations in their response to the microtubule-depolymerizing drug benomyl, compared to that observed in control animals. WB:WBPaper00035150 WB:WBPerson2021 Animals fail to respond to the concentration of fluoride ions that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to fluoride ions to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001855 fluoride resistant Animals fail to respond to the concentration of fluoride ions that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to fluoride ions to elicit the response compared to control animals. WB:WBPaper00035174 WB:WBPerson2021 Animals exhibit variations in their response to ivermectin, an agonist of glutamate-gated chloride channels, compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001856 ivermectin response variant Animals exhibit variations in their response to ivermectin, an agonist of glutamate-gated chloride channels, compared to that observed in control animals. WB:WBPaper00035150 WB:WBPaper00035194 WB:WBPerson2021 Gene expression of an animal is not influenced by the exposure to disease causing agents in the same manner as control animals. C_elegans_phenotype_ontology WBPhenotype:0001857 pathogen induced gene expression variant Gene expression of an animal is not influenced by the exposure to disease causing agents in the same manner as control animals. WB:WBPaper00035315 WB:WBPerson2021 Animals fail to suppress head oscillations in response to anterior touch. In C. elegans, this behavior is a result of tyraminergic signaling. C_elegans_phenotype_ontology Sho WBPhenotype:0001858 suppression of head oscillations defective Animals fail to suppress head oscillations in response to anterior touch. In C. elegans, this behavior is a result of tyraminergic signaling. WB:WBPaper00031692 WB:WBPaper00034683 WB:WBPerson2021 Sho WB:WBPaper00025096 Any variation in the aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes, compared to control. C_elegans_phenotype_ontology DCC localization variant WBPhenotype:0001859 Possible xp. Dosage compensation complex assembly variant Any variation in the aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes, compared to control. GO:0042714 WB:WBPaper00035328 WB:WBPerson2021 Variations in the directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001860 endocytic recycling defective Variations in the directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport, compared to control. GO:0032456 WB:WBPaper00035466 WB:WBPerson2021 Gene expression of an animal is not influenced by environmental changes in the same manner as control animals. C_elegans_phenotype_ontology WBPhenotype:0001861 environmental stimuli induced gene expression variant Gene expression of an animal is not influenced by environmental changes in the same manner as control animals. WB:WBPaper00035435 WB:WBPerson2021 Variations in the regulation of levels, transport, and metabolism of manganese ions within an organism compared to control. C_elegans_phenotype_ontology WBPhenotype:0001862 Possible XP. manganese homeostasis variant Variations in the regulation of levels, transport, and metabolism of manganese ions within an organism compared to control. GO:0030026 WB:WBPaper00035485 WB:WBPerson2021 Animals exhibit variations in their response to manganese compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001863 Possible XP. manganese response variant Animals exhibit variations in their response to manganese compared to that observed in control animals. GO:0010042 WB:WBPaper00035485 WB:WBPerson2021 Any variation in the processes that modulate the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells by means of some external agent such as a transporter or pore compared to control. C_elegans_phenotype_ontology WBPhenotype:0001864 Possible XP. protein transport variant Any variation in the processes that modulate the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells by means of some external agent such as a transporter or pore compared to control. GO:0051223 WB:WBPaper00035491 WB:WBPerson2021 Variations in the process by which one or more ubiquitin moieties are added to a protein, compared to control. C_elegans_phenotype_ontology protein ubiquitylation variant WBPhenotype:0001865 Possible XP. protein ubiquitination variant Variations in the process by which one or more ubiquitin moieties are added to a protein, compared to control. GO:0016567 WB:WBPaper00035602 WB:WBPerson2021 Animals exhibit a reduction in pathogen accumulation, persistent colonization, and luminal distension of the intestine. C_elegans_phenotype_ontology Rpa WBPhenotype:0001866 reduced pathogen accumulation Animals exhibit a reduction in pathogen accumulation, persistent colonization, and luminal distension of the intestine. GO:0009617 GO:0045087 WB:WBPaper00035215 WB:WBPerson2987 Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle asters during a mitotic cell cycle. C_elegans_phenotype_ontology WBPhenotype:0001867 mitotic spindle asters defective early emb Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle asters during a mitotic cell cycle. WB:WBPaper00032910 WB:WBPerson2987 Cells undergoing meiosis exhibit defects in the overall function or activity of the meiotic spindle. C_elegans_phenotype_ontology WBPhenotype:0001868 meiotic spindle defective Cells undergoing meiosis exhibit defects in the overall function or activity of the meiotic spindle. WB:WBPaper00032910 WB:WBPerson2987 Cells undergoing meiosis exhibit defects in the positioning of the meiotic spindle. C_elegans_phenotype_ontology WBPhenotype:0001869 meiotic spindle positioning defective Cells undergoing meiosis exhibit defects in the positioning of the meiotic spindle. WB:WBPaper00032910 WB:WBPerson2987 Cells undergoing meiosis exhibit defects in the rotation of the meiotic spindle. C_elegans_phenotype_ontology WBPhenotype:0001870 meiotic spindle rotation defective Cells undergoing meiosis exhibit defects in the rotation of the meiotic spindle. WB:WBPaper00032910 WB:WBPerson2987 Life span of the animal is not influenced by drug exposure in the same manner as control animals. C_elegans_phenotype_ontology WBPhenotype:0001871 drug induced life span variant Life span of the animal is not influenced by drug exposure in the same manner as control animals. WB:WBPaper00035656 WB:WBPerson2021 Locomotion of the animal is not influenced by drug exposure in the same manner as control animals. C_elegans_phenotype_ontology WBPhenotype:0001872 drug induced locomotion variant Locomotion of the animal is not influenced by drug exposure in the same manner as control animals. WB:WBPaper00035656 WB:WBPerson2021 Early embryos exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the meiotic spindle, the array of microtubules and associated molecules that serves to move duplicated and/or homologous chromosomes apart. C_elegans_phenotype_ontology WBPhenotype:0001873 meiotic spindle assembly defective Early embryos exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the meiotic spindle, the array of microtubules and associated molecules that serves to move duplicated and/or homologous chromosomes apart. WB:WBPaper00032910 WB:WBPerson2987 Any variation in the conjugation of the ubiquitin-like protein Nedd8 to another protein compared to control. C_elegans_phenotype_ontology WBPhenotype:0001874 Possible XP. protein neddylation variant Any variation in the conjugation of the ubiquitin-like protein Nedd8 to another protein compared to control. GO:0045116 WB:WBPerson2021 WB:WBPerson557 Chromosomal masses fail to fully separate and remained linked during anaphase. C_elegans_phenotype_ontology chromosome bridging lagging chromatin WBPhenotype:0001875 anaphase bridging Chromosomal masses fail to fully separate and remained linked during anaphase. WB:WBPerson2021 WB:WBPerson557 Any variation in the formation or disassembly of the cylindrical structures that are composed of groupings of microtubules found close to the nucleus (centrioles) compared to control. Centrioles are arranged perpendicularly and are surrounded by an amorphous mass of dense material (the pericentriolar material). The centrioles and the pericentriolar material constitute the compound structure known as the centrosome. C_elegans_phenotype_ontology WBPhenotype:0001876 centriole biogenesis variant Any variation in the formation or disassembly of the cylindrical structures that are composed of groupings of microtubules found close to the nucleus (centrioles) compared to control. Centrioles are arranged perpendicularly and are surrounded by an amorphous mass of dense material (the pericentriolar material). The centrioles and the pericentriolar material constitute the compound structure known as the centrosome. WB:WBPerson2021 WB:WBPerson557 Any variation in the structure, form or composition of the membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001877 nuclear membrane morphology variant Any variation in the structure, form or composition of the membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated, compared to control. GO:0005634 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the response to the addition of hydroxyurea compared to that observed in control animals. Hydroxyurea stops DNA from being replicated. C_elegans_phenotype_ontology HU response variant hydroxycarbamide response variant WBPhenotype:0001878 hydroxyurea response variant Animals exhibit variations in the response to the addition of hydroxyurea compared to that observed in control animals. Hydroxyurea stops DNA from being replicated. WB:WBPerson2021 WB:WBPerson557 Animals respond to hydroxyurea at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001879 hydroxyurea hypersensitive Animals respond to hydroxyurea at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the form, structure or composition of the endoplasmic reticulum compared to control. The endoplasmic reticulum (ER) is an irregular network of membranes, that occurs in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). C_elegans_phenotype_ontology WBPhenotype:0001880 endoplasmic reticulum morphology variant Any variation in the form, structure or composition of the endoplasmic reticulum compared to control. The endoplasmic reticulum (ER) is an irregular network of membranes, that occurs in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). GO:0005783 WB:WBPaper00025163 WB:WBPerson2987 WB:WBPerson557 Any variation in the normally asymmetric distribution of the endoplasmic reticulum during cell divisions of the early embryo. The endoplasmic reticulum (ER) is an irregular network of membranes, that occurs in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). C_elegans_phenotype_ontology WBPhenotype:0001881 endoplasmic reticulum symmetry variant early emb Any variation in the normally asymmetric distribution of the endoplasmic reticulum during cell divisions of the early embryo. The endoplasmic reticulum (ER) is an irregular network of membranes, that occurs in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). WB:WBPaper00025163 WB:WBPerson2987 Any variation in the number of chromosomes in a cell compared to control. C_elegans_phenotype_ontology WBPhenotype:0001882 aneuploidy Any variation in the number of chromosomes in a cell compared to control. WB:WBPaper00032450 WB:WBPerson2987 Embryos exhibit defects in the formation of the groove in the cell surface near the old metaphase plate at the onset of cytokinesis. C_elegans_phenotype_ontology WBPhenotype:0001885 cleavage furrow initiation defective early emb Embryos exhibit defects in the formation of the groove in the cell surface near the old metaphase plate at the onset of cytokinesis. WB:WBPaper00024200 WB:WBPerson2987 Embryos exhibit defects in the maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis. C_elegans_phenotype_ontology WBPhenotype:0001886 cleavage furrow termination defective early emb Embryos exhibit defects in the maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis. WB:WBPaper00024200 WB:WBPerson2987 Animals execute supernumerary cell divisions during the development of the lateral, alae-producing epithelial cells, resulting in a larger number of these cells than control animals. C_elegans_phenotype_ontology WBPhenotype:0001887 excess seam cells Animals execute supernumerary cell divisions during the development of the lateral, alae-producing epithelial cells, resulting in a larger number of these cells than control animals. WB:WBPaper00032974 WB:WBPerson2987 Animals exhibit an increase in the number of fat containing organelles compared to control. In C. elegans this number can be assayed by increases in the number of BODIPY 493/503 staining. C_elegans_phenotype_ontology lipid body number increased lipid droplet expansion WBPhenotype:0001888 fat associated bodies increased Animals exhibit an increase in the number of fat containing organelles compared to control. In C. elegans this number can be assayed by increases in the number of BODIPY 493/503 staining. WB:WBPaper00035972 WB:WBPerson2021 Any variation in the form, structure or composition of the repeating units of a myofibrils in a muscle cell that are composed of an array of overlapping thick and thin filaments, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001889 body wall muscle sarcomere morphology variant Any variation in the form, structure or composition of the repeating units of a myofibrils in a muscle cell that are composed of an array of overlapping thick and thin filaments, compared to control. GO:0030017 WB:WBPerson557 Any variation in the attachment plaque for thin filaments onto the cell membrane. The dense body in body wall muscles is especially large, indenting far into the cytoplasm to border each sarcomere, thus providing a long row of coherent attachment sites at regular intervals (WormAtlas). C_elegans_phenotype_ontology WBPhenotype:0001890 body wall muscle dense body variant Any variation in the attachment plaque for thin filaments onto the cell membrane. The dense body in body wall muscles is especially large, indenting far into the cytoplasm to border each sarcomere, thus providing a long row of coherent attachment sites at regular intervals (WormAtlas). WB:WBPerson557 Animals exhibit variations in the form, structure or composition of a planar structure within the muscle sarcomere which lies midway within the thick filament (A) band, attaching to the plasma membrane at its base and running up towards the inward surface of the myofilament lattice, compared to control animals (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0001891 M line variant Animals exhibit variations in the form, structure or composition of a planar structure within the muscle sarcomere which lies midway within the thick filament (A) band, attaching to the plasma membrane at its base and running up towards the inward surface of the myofilament lattice, compared to control animals (Wormatlas). WB:WBPerson557 Any variation in the levels of the polymerized form of glucose throughout the body of the animal as compared to controls. C_elegans_phenotype_ontology WBPhenotype:0001892 glycogen levels variant Any variation in the levels of the polymerized form of glucose throughout the body of the animal as compared to controls. WB:WBPaper00033086 WB:WBPerson2987 Any reduction in the membrane potential (voltage gradient) across the inner mitochondrial membrane compared to control. C_elegans_phenotype_ontology WBPhenotype:0001893 mitochondrial membrane potential reduced Any reduction in the membrane potential (voltage gradient) across the inner mitochondrial membrane compared to control. WB:WBPaper00033162 WB:WBPerson2987 Animals exhibit variations in the number of nuclei contained in a particular cell type compared to control. C_elegans_phenotype_ontology WBPhenotype:0001894 nuclear number variant Animals exhibit variations in the number of nuclei contained in a particular cell type compared to control. WB:WBPaper00033438 WB:WBPerson2987 Parental chromosomes fail to undergo appropriate mixing upon pronuclear fusion resulting in a zygotic nucleus in which parental genomes remain segregated. C_elegans_phenotype_ontology pronuclear fusion defective WBPhenotype:0001895 parental chromosome mixing defective Parental chromosomes fail to undergo appropriate mixing upon pronuclear fusion resulting in a zygotic nucleus in which parental genomes remain segregated. GO:0007344 WB:WBPerson2987 Animals exhibit a decrease in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, gamma irradiation, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001896 gamma ray induced apoptosis decreased Animals exhibit a decrease in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, gamma irradiation, compared to control. WB:WBPaper00036343 WB:WBPerson2021 Variations in the state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus (electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light) compared to control. C_elegans_phenotype_ontology Lite WBPhenotype:0001897 light response variant Variations in the state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus (electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light) compared to control. GO:0009416 WB:WBPaper00032087 WB:WBPerson2021 Variations in the process by which sister chromatids, identical chromosomes resulting from DNA replication, are physically separated during the meiotic cell cycle, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001898 meiotic sister chromatid segregation variant Variations in the process by which sister chromatids, identical chromosomes resulting from DNA replication, are physically separated during the meiotic cell cycle, compared to control. WB:WBPaper00034684 WB:WBPerson2987 Animals exhibit variations in the amount of glutathione compared to control animals at a defined stage. Glutathione, the tripeptide glutamylcysteinylglycine, acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. C_elegans_phenotype_ontology WBPhenotype:0001899 glutathione levels variant Animals exhibit variations in the amount of glutathione compared to control animals at a defined stage. Glutathione, the tripeptide glutamylcysteinylglycine, acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. GO:0006749 WB:WBPerson557 Animals exhibit a decrease in the cellular levels of reduced glutathione (GSH), compared to control. Reduced levels of GSH may be an indication of susceptibility to oxidative stress. C_elegans_phenotype_ontology reduced levels of GSH WBPhenotype:0001900 reduced levels of reduced glutathione Animals exhibit a decrease in the cellular levels of reduced glutathione (GSH), compared to control. Reduced levels of GSH may be an indication of susceptibility to oxidative stress. WB:WBPaper00034717 WB:WBPerson2987 Animals exhibit variations in the formation or disassembly of fat containing organelles compared to control. C_elegans_phenotype_ontology lipid body variant WBPhenotype:0001901 fat associated bodies variant Animals exhibit variations in the formation or disassembly of fat containing organelles compared to control. WB:WBPerson557 Animals exhibit an increase in the size of fat containing organelles compared to control. In C. elegans this can be assayed by BODIPY 493/503 staining. C_elegans_phenotype_ontology lipid body size increased WBPhenotype:0001902 fat associated body size increased Animals exhibit an increase in the size of fat containing organelles compared to control. In C. elegans this can be assayed by BODIPY 493/503 staining. WB:WBPaper00034742 WB:WBPerson2987 Animals exhibit variations in the formation, maturation or disassembly of the centrosome (a subcellular body consisting of two centrioles embedded in a protein matrix). The centrosome serves as a microtubule organizing center as well as a regulator of cell-cycle progression. C_elegans_phenotype_ontology WBPhenotype:0001903 centrosome biogenesis variant Animals exhibit variations in the formation, maturation or disassembly of the centrosome (a subcellular body consisting of two centrioles embedded in a protein matrix). The centrosome serves as a microtubule organizing center as well as a regulator of cell-cycle progression. WB:WBPerson557 Animals fail to exhibit toxicity to the concentration of manganese that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans toxic responses to manganese include dopamine (DA) neuron neurodegeneration. C_elegans_phenotype_ontology WBPhenotype:0001904 manganese toxicity resistant Animals fail to exhibit toxicity to the concentration of manganese that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans toxic responses to manganese include dopamine (DA) neuron neurodegeneration. WB:WBPaper00035259 WB:WBPerson557 Animals lay fewer total number of eggs over the lifetime of the animal. C_elegans_phenotype_ontology WBPhenotype:0001905 fewer eggs laid Animals lay fewer total number of eggs over the lifetime of the animal. WB:WBPaper00035252 WB:WBPerson2987 During epidermal morphogenesis, hypodermal cells do not properly undergo the characteristic cell shape changes necessary for the embryo to elongate. C_elegans_phenotype_ontology WBPhenotype:0001906 hypodermal cell elongation defective During epidermal morphogenesis, hypodermal cells do not properly undergo the characteristic cell shape changes necessary for the embryo to elongate. WB:WBPaper00003991 WB:WBPerson712 Animals exhibit defects in the generation of the dorsal epithelial sheet, which entails distinct cell shape changes and movements to affect the interdigitation of two rows of dorsal cells resulting in a single row of cells across the dorsal midline. C_elegans_phenotype_ontology WBPhenotype:0001907 dorsal intercalation defective Animals exhibit defects in the generation of the dorsal epithelial sheet, which entails distinct cell shape changes and movements to affect the interdigitation of two rows of dorsal cells resulting in a single row of cells across the dorsal midline. WB:WBPaper00003991 WB:WBPerson712 The animal displays defects in any step of the ventral enclosure process resulting an embryo that is not enclosed and or with interior cells protruding out of the embryo. C_elegans_phenotype_ontology WBPhenotype:0001908 ventral closure defective The animal displays defects in any step of the ventral enclosure process resulting an embryo that is not enclosed and or with interior cells protruding out of the embryo. WB:WBPaper00003991 WB:WBPerson712 OBSOLETE. Any variation in the prevention of mRNA translation that normally occurs in certain cells, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001909 obsolete translational repression variant true OBSOLETE. Any variation in the prevention of mRNA translation that normally occurs in certain cells, compared to control. WB:WBPerson557 Animals exhibit variations in the assembly, arrangement, orientation, or disassembly of the kinetochore, a multisubunit protein complex on chromosomes where the spindle fibers attach during cell division to pull the chromosomes apart. C_elegans_phenotype_ontology WBPhenotype:0001910 Possible XP. kinetochore organization variant Animals exhibit variations in the assembly, arrangement, orientation, or disassembly of the kinetochore, a multisubunit protein complex on chromosomes where the spindle fibers attach during cell division to pull the chromosomes apart. GO:0051383 WB:WBPaper00035270 WB:WBPerson557 Animals do not regrow axons following axon loss or damage, to the same extent, or in the same manner as observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001911 axon regeneration defective Animals do not regrow axons following axon loss or damage, to the same extent, or in the same manner as observed in control animals. WB:WBPerson557 WB:WBPerson712 The number of coelomocytes are reduced compared to control animals. Coelomocytes are free-floating spherical cells lying in the pseudocoelomic cavity of animals that can endocytose many compounds. C_elegans_phenotype_ontology WBPhenotype:0001912 fewer coelomocytes The number of coelomocytes are reduced compared to control animals. Coelomocytes are free-floating spherical cells lying in the pseudocoelomic cavity of animals that can endocytose many compounds. WB:WBPaper00035290 WB:WBPerson2987 The number of coelomocytes are increased compared to control animals. Coelomocytes are free-floating spherical cells lying in the pseudocoelomic cavity of animals that can endocytose many compounds. C_elegans_phenotype_ontology WBPhenotype:0001913 excess coelomocytes The number of coelomocytes are increased compared to control animals. Coelomocytes are free-floating spherical cells lying in the pseudocoelomic cavity of animals that can endocytose many compounds. WB:WBPaper00035290 WB:WBPerson2987 Animals contain fewer pharyngeal cells compared to control animals. In C. elegans, pharyngeal cells are derived from MS-blastomere. C_elegans_phenotype_ontology WBPhenotype:0001914 fewer pharyngeal cells Animals contain fewer pharyngeal cells compared to control animals. In C. elegans, pharyngeal cells are derived from MS-blastomere. WB:WBPaper00035290 WB:WBPerson2987 Any variation that results in the cellular expression of an mRNA in cells/tissues, that is otherwise not observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0001915 mRNA expression ectopic Any variation that results in the cellular expression of an mRNA in cells/tissues, that is otherwise not observed in control animals. WB:WBPaper00035290 WB:WBPerson2987 Pathogens internally associated with the animal exhibit an increase in survival compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001916 increased pathogen survival Pathogens internally associated with the animal exhibit an increase in survival compared to control animals. WB:WBPaper00035289 WB:WBPerson2987 Variations in the processes that incorporate acetyl groups to one or more amino acids within a protein, compared to control. An acetyl group is CH3CO-. C_elegans_phenotype_ontology WBPhenotype:0001917 protein acetylation variant Variations in the processes that incorporate acetyl groups to one or more amino acids within a protein, compared to control. An acetyl group is CH3CO-. GO:0006473 WB:WBPaper00025192 WB:WBPerson557 Animals respond to a specific chemical at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001918 chemical hypersensitive Animals respond to a specific chemical at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals exhibit larger inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes. In C. elegans these contents typically include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0001919 gut granules enlarged Animals exhibit larger inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes. In C. elegans these contents typically include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas). WB:WBPaper00035924 WB:WBPerson2987 The growth of pharyngeal components occurs in a radial fashion around the longitudinal axis of the worm as demonstrated by bent radial contractile arrays within the pharyngeal muscle cells. The defect is more pronounced as development progresses resulting in a more obvious twisting phenotype. Depending on the allele, the twist can be right-handed or left-handed C_elegans_phenotype_ontology Twp pharynx twisted WBPhenotype:0001920 twisted pharynx The growth of pharyngeal components occurs in a radial fashion around the longitudinal axis of the worm as demonstrated by bent radial contractile arrays within the pharyngeal muscle cells. The defect is more pronounced as development progresses resulting in a more obvious twisting phenotype. Depending on the allele, the twist can be right-handed or left-handed WB:WBPaper00030736 WB:WBPerson712 Any variation in the creation of double-strand breaks that occur during meiosis that may result in the initiation of meiotic recombination. C_elegans_phenotype_ontology WBPhenotype:0001921 Possible XP. meiotic DNA double strand break formation variant Any variation in the creation of double-strand breaks that occur during meiosis that may result in the initiation of meiotic recombination. GO:0042138 WB:WBPerson557 Any variation in the directed movement of organelles or molecules along microtubules in nerve cell axons. axon transport variant C_elegans_phenotype_ontology axon cargo transport variant WBPhenotype:0001922 Possible XP. axonal transport variant Any variation in the directed movement of organelles or molecules along microtubules in nerve cell axons. GO:0008088 WB:WBPerson557 The population of the lateral, alae-producing epithelial cells (seam cells) is reduced compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001923 fewer seam cells The population of the lateral, alae-producing epithelial cells (seam cells) is reduced compared to control animals. WB:WBPaper00034768 Oocytes are found one on top of the other in the dorsal to ventral orientation in the gonad. C_elegans_phenotype_ontology WBPhenotype:0001924 oocytes stacked Oocytes are found one on top of the other in the dorsal to ventral orientation in the gonad. WB:WBPerson557 Oocytes are no longer arranged in the gonad in the same manner as control animals. C_elegans_phenotype_ontology WBPhenotype:0001925 oocytes disorganized Oocytes are no longer arranged in the gonad in the same manner as control animals. WB:WBPerson557 Basal contraction rate and or peak contraction rate of the gonadal sheath is increased relative to control animals. C_elegans_phenotype_ontology WBPhenotype:0001926 gonad sheath contraction rate increased Basal contraction rate and or peak contraction rate of the gonadal sheath is increased relative to control animals. WB:WBPaper00027739 WB:WBPerson2987 Animals produce an excess number of distal tip cells compared to controls. C_elegans_phenotype_ontology WBPhenotype:0001927 extra distal tip cells Animals produce an excess number of distal tip cells compared to controls. WB:WBPaper00033102 WB:WBPerson2987 Animals produce an excess number of gonad arms compared to controls. C_elegans_phenotype_ontology WBPhenotype:0001928 extra gonad arms Animals produce an excess number of gonad arms compared to controls. WB:WBPaper00033102 WB:WBPerson2987 The gonads of male animals do not produce the linker cell involved in guiding the developing male gonad to the sex organs in the male tail. C_elegans_phenotype_ontology WBPhenotype:0001929 linker cell absent The gonads of male animals do not produce the linker cell involved in guiding the developing male gonad to the sex organs in the male tail. WB:WBPaper00033102 WB:WBPerson2987 Animals extend altered or fewer numbers of dorsal and or ventral muscle arms compared to control animals. C_elegans_phenotype_ontology Madd muscle arm extension defective WBPhenotype:0001930 muscle arm development defective Animals extend altered or fewer numbers of dorsal and or ventral muscle arms compared to control animals. WB:WBPaper00032907 WB:WBPerson712 The morphology or number of connections between muscle arms and commissural motor axons varies from control animals. C_elegans_phenotype_ontology WBPhenotype:0001931 muscle arm axon connection variant The morphology or number of connections between muscle arms and commissural motor axons varies from control animals. WB:WBPaper00032907 WB:WBPerson712 Animals exhibit ectopic plasma membrane extensions from muscle, these extensions are random projections that are thinner than the typical muscle arm. C_elegans_phenotype_ontology WBPhenotype:0001932 myopodia present Animals exhibit ectopic plasma membrane extensions from muscle, these extensions are random projections that are thinner than the typical muscle arm. WB:WBPaper00032907 WB:WBPerson712 The pattern of localization of presynaptic markers is disrupted compared to control animals. C_elegans_phenotype_ontology Sam WBPhenotype:0001933 synaptic vesicle tag abnormal in mechanosensory neurons The pattern of localization of presynaptic markers is disrupted compared to control animals. WB:WBPaper00035070 WB:WBPerson712 Any variation in the extension of vulval muscles compared to control. In C. elegans contralateral vulval muscles fail to meet at the midline. C_elegans_phenotype_ontology Vme WBPhenotype:0001934 vulval muscle extension variant Any variation in the extension of vulval muscles compared to control. In C. elegans contralateral vulval muscles fail to meet at the midline. WB:WBPaper00036485 WB:WBPerson712 Animals become paralyzed in response to aggregation of proteins like poly-glutamine or beta-amyloid. C_elegans_phenotype_ontology WBPhenotype:0001935 protein aggregation induced paralysis Animals become paralyzed in response to aggregation of proteins like poly-glutamine or beta-amyloid. WB:WBPaper00033115 WB:WBPerson2987 Animals fail to respond to the aggregation of proteins that elicits a paralysis response in control animals. C_elegans_phenotype_ontology WBPhenotype:0001936 resistant to protein aggregation induced paralysis Animals fail to respond to the aggregation of proteins that elicits a paralysis response in control animals. WB:WBPaper00033115 WB:WBPerson2987 Animals respond to protein aggregation at a lower concentration of aggregates or in less time compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001937 hypersensitive to protein aggregation induced paralysis Animals respond to protein aggregation at a lower concentration of aggregates or in less time compared to control animals. WB:WBPaper00033115 WB:WBPerson2987 Any variation in the process of restoring DNA after damage. DNA damage can be caused by a many chemical or physical agents, and this damage is repaired by a variety of different DNA repair pathways. C_elegans_phenotype_ontology WBPhenotype:0001938 DNA repair variant Any variation in the process of restoring DNA after damage. DNA damage can be caused by a many chemical or physical agents, and this damage is repaired by a variety of different DNA repair pathways. GO:0006281 WB:WBPerson557 Animals are not repelled by bitter tastants such as quinine, primaquine quinacrine etc., to the same extent as control animals. C_elegans_phenotype_ontology WBPhenotype:0001939 bitter tastant response variant Animals are not repelled by bitter tastants such as quinine, primaquine quinacrine etc., to the same extent as control animals. WB:WBPaper00035961 WB:WBPerson712 Any variation in the form, structure or composition of the nucleus-free core of germ line cytoplasm in the gonad compared to control animals. In the C. elegans germline, nuclei exiting mitosis and entering meiosis are arranged along the cortex of the germline, partially enclosed by cellular membrane, forming a nucleus-free core of germline cytoplasm, called the rachis. C_elegans_phenotype_ontology rachis morphology abnormal WBPhenotype:0001940 rachis morphology variant Any variation in the form, structure or composition of the nucleus-free core of germ line cytoplasm in the gonad compared to control animals. In the C. elegans germline, nuclei exiting mitosis and entering meiosis are arranged along the cortex of the germline, partially enclosed by cellular membrane, forming a nucleus-free core of germline cytoplasm, called the rachis. WB:WBPaper00031889 WB:WBPerson557 The nucleus-free core of germline cytoplasm in the gonad is not as wide as control animals. C_elegans_phenotype_ontology WBPhenotype:0001941 rachis narrow The nucleus-free core of germline cytoplasm in the gonad is not as wide as control animals. WB:WBPaper00038381 WB:WBPerson557 The nucleus-free core of germline cytoplasm in the gonad is missing. C_elegans_phenotype_ontology WBPhenotype:0001942 rachis absent The nucleus-free core of germline cytoplasm in the gonad is missing. WB:WBPaper00038381 WB:WBPerson557 The width of the nucleus-free core of germline cytoplasm in the gonad is larger compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001943 rachis wide The width of the nucleus-free core of germline cytoplasm in the gonad is larger compared to control animals. WB:WBPaper00038381 WB:WBPerson557 A decreased number of celullarized haploid female germ cells (oocytes) are present in the gonad compared to control. C_elegans_phenotype_ontology fewer oocytes WBPhenotype:0001944 oocyte number decreased A decreased number of celullarized haploid female germ cells (oocytes) are present in the gonad compared to control. WB:WBPaper00038381 WB:WBPerson557 The size of haploid female germ cells (oocytes) are significantly smaller compared to control. C_elegans_phenotype_ontology WBPhenotype:0001945 oocytes small The size of haploid female germ cells (oocytes) are significantly smaller compared to control. WB:WBPaper00038381 WB:WBPerson557 Developing oocytes show defects in their entry, progression through or exit from the pachytene stage compared to control animals. Pachytene is a cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome. C_elegans_phenotype_ontology WBPhenotype:0001946 pachytene progression during oogenesis variant Developing oocytes show defects in their entry, progression through or exit from the pachytene stage compared to control animals. Pachytene is a cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome. GO:0000239 WB:WBPaper00038381 WB:WBPerson557 Developing oocytes show defects in their entry, progression through or exit from the diplotene stage compared to control animals. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves. C_elegans_phenotype_ontology WBPhenotype:0001947 diplotene progression during oogenesis variant Developing oocytes show defects in their entry, progression through or exit from the diplotene stage compared to control animals. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves. GO:0000240 WB:WBPaper00038381 WB:WBPerson557 Developing oocytes show defects in their entry, progression through or exit from the diakinesis stage compared to control animals. Diakinesis is a cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I. C_elegans_phenotype_ontology WBPhenotype:0001948 diakinesis progression during oogenesis variant Developing oocytes show defects in their entry, progression through or exit from the diakinesis stage compared to control animals. Diakinesis is a cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I. GO:0000241 WB:WBPaper00038381 WB:WBPerson557 Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diakinesis stage. In C. elegans the diakinesis region occurs in the proximal gonad arm and is preceded by the diplotene region. In the diakinesis region oocytes arrest until oocyte maturation occurs. C_elegans_phenotype_ontology WBPhenotype:0001949 diakinesis region organization variant Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diakinesis stage. In C. elegans the diakinesis region occurs in the proximal gonad arm and is preceded by the diplotene region. In the diakinesis region oocytes arrest until oocyte maturation occurs. WB:WBPaper00038381 WB:WBPerson557 Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diplotene stage. In C. elegans the diplotene region follows the pachytene region and occurs just distal to, and coincident with, the loop in the gonad arm. In the diplotene region germ cell compartments become organized into a single file. C_elegans_phenotype_ontology WBPhenotype:0001950 diplotene region organization variant Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diplotene stage. In C. elegans the diplotene region follows the pachytene region and occurs just distal to, and coincident with, the loop in the gonad arm. In the diplotene region germ cell compartments become organized into a single file. WB:WBPaper00038381 WB:WBPerson557 Animals exhibit variations from control animals in the organization of the germ cell nuclei in the pachytene stage region of the gonad. In C. elegans the pachytene region begins just proximal to the germline's transition zone, where germ cells coordinately switch into the leptotene/zygotene stage from the premeiosis stage (WormAtlas). C_elegans_phenotype_ontology WBPhenotype:0001951 pachytene region organization variant Animals exhibit variations from control animals in the organization of the germ cell nuclei in the pachytene stage region of the gonad. In C. elegans the pachytene region begins just proximal to the germline's transition zone, where germ cells coordinately switch into the leptotene/zygotene stage from the premeiosis stage (WormAtlas). WB:WBPaper00038381 WB:WBPerson557 Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control. C_elegans_phenotype_ontology germline nuclear migration variant WBPhenotype:0001952 germline nuclear positioning variant Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control. WB:WBPaper00038381 WB:WBPerson557 Nuclei have fallen out of developing germ cell compartments into the rachis. C_elegans_phenotype_ontology WBPhenotype:0001953 nuclear fallout Nuclei have fallen out of developing germ cell compartments into the rachis. WB:WBPaper00038381 WB:WBPerson557 The diplotene stage is not observed in developing oocytes. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves. C_elegans_phenotype_ontology WBPhenotype:0001954 diplotene absent during oogenesis The diplotene stage is not observed in developing oocytes. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves. GO:0000240 WB:WBPaper00038381 WB:WBPerson557 Haploid female germ cells (oocytes) contain more than one nucleus. C_elegans_phenotype_ontology multinucleate oocyte WBPhenotype:0001955 multiple nuclei oocyte Haploid female germ cells (oocytes) contain more than one nucleus. WB:WBPaper00038381 WB:WBPerson557 Haploid female germ cells (oocytes) lack a nucleus. C_elegans_phenotype_ontology anucleate oocytes WBPhenotype:0001956 oocytes lack nucleus Haploid female germ cells (oocytes) lack a nucleus. WB:WBPaper00038381 WB:WBPerson557 A decrease in size of the specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0001957 gonad small A decrease in size of the specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas). WB:WBPaper00038381 WB:WBPerson557 Animals contain a gonad that initially functioned, but subsequently stopped. In hermaphrodites or females there is often the presence old embryos and/or hatched larva, but no young embryos, in the uterus. C_elegans_phenotype_ontology degenerate gonad WBPhenotype:0001958 gonad degenerate Animals contain a gonad that initially functioned, but subsequently stopped. In hermaphrodites or females there is often the presence old embryos and/or hatched larva, but no young embryos, in the uterus. WB:WBPaper00038381 WB:WBPerson557 Pulling forces on the astral microtubules at the spindle poles vary from that observed for control spindles. C_elegans_phenotype_ontology WBPhenotype:0001959 spindle pole pulling force variant Pulling forces on the astral microtubules at the spindle poles vary from that observed for control spindles. WB:WBPaper00031928 WB:WBPerson712 The spindle in the early embryo is aberrant in the characteristic posterior aster oscillations that occur along the transverse longitudinal axis of the spindle. C_elegans_phenotype_ontology WBPhenotype:0001960 spindle oscillation variant The spindle in the early embryo is aberrant in the characteristic posterior aster oscillations that occur along the transverse longitudinal axis of the spindle. WB:WBPaper00031928 WB:WBPerson712 Animals continue to produce progeny significantly past the time reproduction stops in control animals. C_elegans_phenotype_ontology WBPhenotype:0001961 reproductive longevity extended Animals continue to produce progeny significantly past the time reproduction stops in control animals. WB:WBPaper00031688 WB:WBPerson712 Animals produce less distal tip cells compared to controls. C_elegans_phenotype_ontology WBPhenotype:0001962 missing distal tip cells Animals produce less distal tip cells compared to controls. WB:WBPaper00026603 WB:WBPerson557 WB:WBPerson712 The association of homologs during diakinesis and the maintenance of their association through meiosis I as well as the preservation of centromeric cohesin between sister chromatids does not proceed as it does in control animals. C_elegans_phenotype_ontology WBPhenotype:0001963 homolog association variant The association of homologs during diakinesis and the maintenance of their association through meiosis I as well as the preservation of centromeric cohesin between sister chromatids does not proceed as it does in control animals. WB:WBPaper00032269 WB:WBPerson712 Animals exhibit differential regulation of the dopaminergic fate among the various classes of dopaminergic neurons. C_elegans_phenotype_ontology Dopy WBPhenotype:0001964 dopaminergic fate atypical Animals exhibit differential regulation of the dopaminergic fate among the various classes of dopaminergic neurons. WB:WBPaper00032147 WB:WBPaper00036201 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for the composition, component distribution, or other aspect of membranes of the cell, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001965 cell membrane physiology variant Animals exhibit variations in any physical or chemical process required for the composition, component distribution, or other aspect of membranes of the cell, compared to control animals. WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any physical or chemical process required for the composition, component distribution, or other aspect of membranes of within the cell, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001966 cell endomembrane physiology variant Animals exhibit variations in any physical or chemical process required for the composition, component distribution, or other aspect of membranes of within the cell, compared to control animals. WB:WBPaper00037899 WB:WBPerson712 Animals differ from control animals in the length of or mechanics of the steps that culminate in the preservation and subsequent disassembly of the synaptonemal complex, the specification of bivalent arms, and proper cohesion of sister chromatids. C_elegans_phenotype_ontology WBPhenotype:0001967 meiotic chromatin reorganization variant Animals differ from control animals in the length of or mechanics of the steps that culminate in the preservation and subsequent disassembly of the synaptonemal complex, the specification of bivalent arms, and proper cohesion of sister chromatids. WB:WBPaper00032269 WB:WBPerson712 All somatic gonad precursor (SGP) daughters adopt a proximal fate resulting in an increase in the number of AC precursor cells at the expense of distal tip cells (DTC), which are thereby absent. Sys C_elegans_phenotype_ontology symmetrical sisters WBPhenotype:0001968 somatic gonad precursor symmetrical sisters All somatic gonad precursor (SGP) daughters adopt a proximal fate resulting in an increase in the number of AC precursor cells at the expense of distal tip cells (DTC), which are thereby absent. WB:WBPaper00026603 WB:WBPerson712 Any variation in the form or composition of the compartments in the germline of females/hermaphrodites compared to control animals. In C. elegans these compartments contain a nucleus and are connected to a common cytoplasm (rachis). These compartments eventually undergo cellularization and become oocytes. C_elegans_phenotype_ontology WBPhenotype:0001969 germ cell compartment morphology variant Any variation in the form or composition of the compartments in the germline of females/hermaphrodites compared to control animals. In C. elegans these compartments contain a nucleus and are connected to a common cytoplasm (rachis). These compartments eventually undergo cellularization and become oocytes. WB:WBPaper00038381 WB:WBPerson557 Germ cell compartments contain an an atypical number on nuclei compared to control. C_elegans_phenotype_ontology WBPhenotype:0001970 germ cell compartment nuclei number variant Germ cell compartments contain an an atypical number on nuclei compared to control. WB:WBPaper00038381 WB:WBPerson557 Germ cell compartments do not contain a nucleus. C_elegans_phenotype_ontology WBPhenotype:0001971 germ cell compartment anucleate Germ cell compartments do not contain a nucleus. WB:WBPaper00038381 WB:WBPerson557 Germ cell compartments contain multiple nuclei. C_elegans_phenotype_ontology WBPhenotype:0001972 germ cell compartment multinucleate Germ cell compartments contain multiple nuclei. WB:WBPaper00038381 WB:WBPerson557 Any variation in germ cell compartment size compared to control. C_elegans_phenotype_ontology WBPhenotype:0001973 germ cell compartment size variant Any variation in germ cell compartment size compared to control. WB:WBPaper00038381 WB:WBPerson557 Germ cell compartments are smaller than that of control animals. C_elegans_phenotype_ontology WBPhenotype:0001974 germ cell compartment small Germ cell compartments are smaller than that of control animals. WB:WBPaper00038381 WB:WBPerson557 Germ cell compartments are larger than that of control animals. C_elegans_phenotype_ontology WBPhenotype:0001975 germ cell compartment large Germ cell compartments are larger than that of control animals. WB:WBPaper00038381 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0001976 true Any variation in the form or composition of the compartment partitions in the germline of females/hermaphrodites that exist when nuclei are still connected to a common cytoplasm (rachis), compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001977 germ cell partition morphology variant Any variation in the form or composition of the compartment partitions in the germline of females/hermaphrodites that exist when nuclei are still connected to a common cytoplasm (rachis), compared to control animals. WB:WBPaper00038381 WB:WBPerson557 Animals lack germ cell partitions (germ cell compartments). WBPhenotype:0001976 germ cell compartment absent C_elegans_phenotype_ontology WBPhenotype:0001978 germ cell partition absent Animals lack germ cell partitions (germ cell compartments). WB:WBPaper00038381 WB:WBPerson557 Animals contain small, fluid-filled, anucleate, spherical membrane-bound structures within the gonad. C_elegans_phenotype_ontology WBPhenotype:0001979 gonad vesiculated Animals contain small, fluid-filled, anucleate, spherical membrane-bound structures within the gonad. GO:0031982 WB:WBPaper00038381 WB:WBPerson557 Animals exhibit variations in the increase in size of compartments of the germline. In the C. elegans germline, syncytial compartments enlarge just prior to and coincident with the loop region, eventually abscising, to become fully enclosed germ cells (oocytes). C_elegans_phenotype_ontology WBPhenotype:0001980 germ cell compartment expansion variant Animals exhibit variations in the increase in size of compartments of the germline. In the C. elegans germline, syncytial compartments enlarge just prior to and coincident with the loop region, eventually abscising, to become fully enclosed germ cells (oocytes). WB:WBPaper00038381 WB:WBPerson557 The compartments of the germline do not increase in size. C_elegans_phenotype_ontology WBPhenotype:0001981 germ cell compartment expansion absent The compartments of the germline do not increase in size. WB:WBPaper00038381 WB:WBPerson557 Variations in the process(es) involved in the assembly, transport, arrangement or disassembly of cell membrane structures or components compared to control. C_elegans_phenotype_ontology WBPhenotype:0001982 cell membrane organization biogenesis variant Variations in the process(es) involved in the assembly, transport, arrangement or disassembly of cell membrane structures or components compared to control. WB:WBPaper00038381 WB:WBPerson557 Variation of the time an individual spent on a patch of food (bacterial lawn) before leaving, compared to control animals. food leaving behavior variant patch leaving behavior variant exploratory behavior variant C_elegans_phenotype_ontology exploration behavior variant WBPhenotype:0001983 lawn leaving behavior variant Variation of the time an individual spent on a patch of food (bacterial lawn) before leaving, compared to control animals. WB:WBPaper00038234 WB:WBPerson363 Animals exhibit axons with migration behaviors that differ from those observed in control animals after the axons cross a half-way point between opposing neural cords. In C. elegans this point is marked by the lateral seam cells between the ventral and dorsal cords. C_elegans_phenotype_ontology WBPhenotype:0001984 long range axon migration variant Animals exhibit axons with migration behaviors that differ from those observed in control animals after the axons cross a half-way point between opposing neural cords. In C. elegans this point is marked by the lateral seam cells between the ventral and dorsal cords. WB:WBPaper00038105 WB:WBPerson712 Animals exhibit axons with migration behaviors that differ from those observed in control animals before the axons reach a half-way point between opposing neural cords. In C. elegans this point is marked by the lateral seam cells between the ventral and dorsal cords. C_elegans_phenotype_ontology WBPhenotype:0001985 short range axon migration variant Animals exhibit axons with migration behaviors that differ from those observed in control animals before the axons reach a half-way point between opposing neural cords. In C. elegans this point is marked by the lateral seam cells between the ventral and dorsal cords. WB:WBPaper00038105 WB:WBPerson712 Animals undergo an irreversible high temperature-induced developmental arrest during the first larval stage. C_elegans_phenotype_ontology WBPhenotype:0001986 high temperature induced L1 arrest Animals undergo an irreversible high temperature-induced developmental arrest during the first larval stage. WB:WBPaper00038168 WB:WBPerson2987 Any variation in the measured levels of acetylcholinesterase (AChE) activity compared to control animals. acetylcholinesterase class activity variant C_elegans_phenotype_ontology WBPhenotype:0001987 acetylcholinesterase activity variant Any variation in the measured levels of acetylcholinesterase (AChE) activity compared to control animals. WB:WBPaper00001039 WB:WBPerson712 Animals respond to a detergent at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0001988 detergent hypersensitive Animals respond to a detergent at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00000514 WB:WBPerson712 Animals respond to hypoxic (low oxygen levels) stress after a shorter exposure time compared to control. C_elegans_phenotype_ontology WBPhenotype:0001989 hypoxia hypersensitive Animals respond to hypoxic (low oxygen levels) stress after a shorter exposure time compared to control. WB:WBPerson557 WB:WBPerson712 Animals fail to respond to low amounts of oxygen that elicit a response in control animals. C_elegans_phenotype_ontology WBPhenotype:0001990 hypoxia resistant Animals fail to respond to low amounts of oxygen that elicit a response in control animals. WB:WBPerson557 WB:WBPerson712 Response to low levels of oxygen is reduced or weakened compared to the response of control animals. C_elegans_phenotype_ontology WBPhenotype:0001991 hypoxia response attenuated Response to low levels of oxygen is reduced or weakened compared to the response of control animals. WB:WBPerson557 WB:WBPerson712 Animals exhibit an increase in the number of somatic sheath cells surrounding each gonad arm compared to controls. C_elegans_phenotype_ontology WBPhenotype:0001992 extra gonadal sheath cells Animals exhibit an increase in the number of somatic sheath cells surrounding each gonad arm compared to controls. WB:WBPaper00006209 WB:WBPerson2987 Animals exhibit fewer somatic sheath cells surrounding each gonad arm, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0001993 fewer gonadal sheath cells Animals exhibit fewer somatic sheath cells surrounding each gonad arm, compared to controls. WB:WBPaper00006209 WB:WBPerson2987 Any variation in the establishment of left-right asymmetry of the body axis compared to controls. C_elegans_phenotype_ontology left right asymmetry variant WBPhenotype:0001994 left right handedness variant Any variation in the establishment of left-right asymmetry of the body axis compared to controls. WB:WBPerson2987 WB:WBPerson557 Cells of the animals exhibit variations in the progression or exit from the biochemical and morphological processes that occur during successive replication or nuclear replication events from that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0001995 cell cycle progression variant Cells of the animals exhibit variations in the progression or exit from the biochemical and morphological processes that occur during successive replication or nuclear replication events from that observed for control animals. GO:0007049 WB:WBPerson557 WB:WBPerson712 Any variation in the cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence before entering the S phase, compared to control. C_elegans_phenotype_ontology WBPhenotype:0001996 cell cycle quiescence variant Any variation in the cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence before entering the S phase, compared to control. GO:0070314 WB:WBPerson557 WB:WBPerson712 The nucleus or nuclei are not positioned in a similar manner or pattern in the cell or syncytium to that observed in controls. C_elegans_phenotype_ontology WBPhenotype:0001997 nuclear anchoring variant The nucleus or nuclei are not positioned in a similar manner or pattern in the cell or syncytium to that observed in controls. WB:WBPaper00003628 WB:WBPerson712 Animals respond more severely to laser ablation than control animals subjected to the same laser ablation conditions. C_elegans_phenotype_ontology WBPhenotype:0001998 hypersensitive to laser ablation Animals respond more severely to laser ablation than control animals subjected to the same laser ablation conditions. WB:WBPaper00038282 WB:WBPerson712 Animals behave differently from control animals in assays testing for the ability to resolve or respond to conflicting sensory inputs. C_elegans_phenotype_ontology WBPhenotype:0001999 conflicting sensory integration variant Animals behave differently from control animals in assays testing for the ability to resolve or respond to conflicting sensory inputs. WB:WBPaper00038243 WB:WBPerson712 Animals that exhibit an increase in locomotion activity do not return to basal level locomotion activity at the same rate as that of control animals. C_elegans_phenotype_ontology WBPhenotype:0002000 recovery from enhanced locomotion variant Animals that exhibit an increase in locomotion activity do not return to basal level locomotion activity at the same rate as that of control animals. WB:WBPaper00038487 WB:WBPerson712 The number of synapses per unit area of a neuron differs in the animal compared to that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0002001 synapse density variant The number of synapses per unit area of a neuron differs in the animal compared to that observed for control animals. WB:WBPaper00039786 WB:WBPerson712 A cell or cell of the animal exhibits extra centrosomes (a subcellular body consisting of two centrioles embedded in a protein matrix) compared to control. C_elegans_phenotype_ontology WBPhenotype:0002002 supernumerary centrosomes A cell or cell of the animal exhibits extra centrosomes (a subcellular body consisting of two centrioles embedded in a protein matrix) compared to control. WB:WBPaper00028464 WB:WBPerson2987 Animals exhibit variations in steady-state levels of hydrogen peroxide (H2O2) compared to control. C_elegans_phenotype_ontology WBPhenotype:0002003 hydrogen peroxide homeostasis variant Animals exhibit variations in steady-state levels of hydrogen peroxide (H2O2) compared to control. WB:WBPaper00040082 WB:WBPerson712 Animals exhibit defects in the flow rate or targeting of the cortical actomyosin network, which occurs during polarization as well as contraction of the contractile ring, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002004 actomyosin contractility defective Animals exhibit defects in the flow rate or targeting of the cortical actomyosin network, which occurs during polarization as well as contraction of the contractile ring, compared to control animals. WB:WBPaper00038098 WB:WBPerson712 The tension of the cytoskeleton comprised of the actomyosin network differs from controls. This tension can be measured by laser-cutting of the actomyosin cytoskeleton and observing any differences the recoil velocity of cortex adjacent to the cut site. C_elegans_phenotype_ontology WBPhenotype:0002005 actomyosin cytoskeletal tension variant The tension of the cytoskeleton comprised of the actomyosin network differs from controls. This tension can be measured by laser-cutting of the actomyosin cytoskeleton and observing any differences the recoil velocity of cortex adjacent to the cut site. WB:WBPaper00038098 WB:WBPerson712 Compared to controls, embryos exhibit variations in the part meiosis I in which homologous chromosomes separate and migrate away from each other. C_elegans_phenotype_ontology WBPhenotype:0002006 anaphase I progression variant early embryo Compared to controls, embryos exhibit variations in the part meiosis I in which homologous chromosomes separate and migrate away from each other. WB:WBPaper00031064 WB:WBPerson712 Embryos display cortical protusions during cytokinesis. C_elegans_phenotype_ontology WBPhenotype:0002007 cortical blebs present Embryos display cortical protusions during cytokinesis. WB:WBPaper00038098 WB:WBPerson712 Animals exhibit variations in the non-enzymatic glycosylation process of attaching a protein or lipid to a sugar molecule, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002008 glycation variant Animals exhibit variations in the non-enzymatic glycosylation process of attaching a protein or lipid to a sugar molecule, compared to control animals. WB:WBPaper00040082 WB:WBPerson712 Animals exhibit variations from controls in their protein degradation machinery, which functions through the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. C_elegans_phenotype_ontology WBPhenotype:0002009 proteasome core activity variant Animals exhibit variations from controls in their protein degradation machinery, which functions through the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. GO:0004175 WB:WBPaper00040082 WB:WBPerson712 The dynamics of the replacement of old proteins by newly synthesized or modified proteins varies from that of control animals. This phenotype is often measured by fluorescence recovery after photobleaching (FRAP). C_elegans_phenotype_ontology WBPhenotype:0002010 protein turnover variant The dynamics of the replacement of old proteins by newly synthesized or modified proteins varies from that of control animals. This phenotype is often measured by fluorescence recovery after photobleaching (FRAP). WB:WBPaper00038098 WB:WBPerson712 Animals exhibit a secondary vulval invagination that is anterior or posterior to the primary opening depending on the the inappropriate placement of daughter cells along the anterior/posterior axis during vulval development. C_elegans_phenotype_ontology WBPhenotype:0002011 bivulva Animals exhibit a secondary vulval invagination that is anterior or posterior to the primary opening depending on the the inappropriate placement of daughter cells along the anterior/posterior axis during vulval development. WB:WBPaper00040151 WB:WBPerson712 Any variation in the process of chromosome organization that is involved in meiosis, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002012 meiotic chromosome organization variant Any variation in the process of chromosome organization that is involved in meiosis, compared to control. GO:0070192 WB:WBPerson557 Chromosomes fails to pair with homologous chromosomes during the prophase stage of meiosis. C_elegans_phenotype_ontology WBPhenotype:0002013 univalent meiotic chromosomes Chromosomes fails to pair with homologous chromosomes during the prophase stage of meiosis. WB:WBPerson101 WB:WBPerson557 Any observed variation in the measurement of current across the cell membrane compared to measurements in control animals. Current is a flow of electric charge through a medium. C_elegans_phenotype_ontology WBPhenotype:0002014 current measurement variant Any observed variation in the measurement of current across the cell membrane compared to measurements in control animals. Current is a flow of electric charge through a medium. WB:WBPerson557 Any observed variation in the measurement of voltage across the cell membrane compared to measurements in control animals. Voltage is the difference in electric potential energy per unit charge between two points. C_elegans_phenotype_ontology WBPhenotype:0002015 voltage measurement variant Any observed variation in the measurement of voltage across the cell membrane compared to measurements in control animals. Voltage is the difference in electric potential energy per unit charge between two points. WB:WBPerson557 Failure to execute the characteristic response to biotin as defined by control animals. In C. elegans, biotin is typically an attractant. C_elegans_phenotype_ontology WBPhenotype:0002016 biotin chemotaxis defective Failure to execute the characteristic response to biotin as defined by control animals. In C. elegans, biotin is typically an attractant. WB:WBPaper00001481 WB:WBPaper00005801 WB:WBPerson101 WB:WBPerson557 Any variation in the ability of multipotent vulval precursor cells to respond to signals compared to control animals. C_elegans_phenotype_ontology vulval precursor cell competence abnormal vulval precursor cell competence variant WBPhenotype:0002017 VPC competence variant Any variation in the ability of multipotent vulval precursor cells to respond to signals compared to control animals. WB:WBPerson557 Seam cells fuse to form a continuous syncytium along the body wall at a later stage of development compared to control. C_elegans_phenotype_ontology WBPhenotype:0002018 retarded seam cell fusion Seam cells fuse to form a continuous syncytium along the body wall at a later stage of development compared to control. WB:WBPaper00031488 WB:WBPerson2987 Adult animals display a smaller number of eggs inside the uterus compared to controls C_elegans_phenotype_ontology WBPhenotype:0002019 fewer eggs in utero Adult animals display a smaller number of eggs inside the uterus compared to controls WB:WBPaper00031804 WB:WBPerson2987 Transmission of the signal along the neuron varies from control. This process includes the flow of information from the neuron cell body to the synapse and across to the postsynaptic cell. C_elegans_phenotype_ontology WBPhenotype:0002020 transmission of nerve impulse variant Transmission of the signal along the neuron varies from control. This process includes the flow of information from the neuron cell body to the synapse and across to the postsynaptic cell. GO:0019226 WB:WBPaper00031592 WB:WBPerson712 Animals exhibit variations in the autonomously initiated periodic trains of calcium transients observed at the synapse, which are independent of presynaptic inputs. C_elegans_phenotype_ontology WBPhenotype:0002021 synaptic spike frequency variant Animals exhibit variations in the autonomously initiated periodic trains of calcium transients observed at the synapse, which are independent of presynaptic inputs. WB:WBPaper00031592 WB:WBPerson712 Calcium transients at presynaptic regions do not occur. C_elegans_phenotype_ontology WBPhenotype:0002022 no synaptic spike frequency Calcium transients at presynaptic regions do not occur. WB:WBPaper00031592 WB:WBPerson712 Animals exhibit variations in the autonomously initiated periodic trains of calcium transients observed either at the cell body or the synaptic region, which are independent of presynaptic inputs. C_elegans_phenotype_ontology WBPhenotype:0002023 spike frequency variant Animals exhibit variations in the autonomously initiated periodic trains of calcium transients observed either at the cell body or the synaptic region, which are independent of presynaptic inputs. WB:WBPaper00031592 WB:WBPerson712 Animals exhibit variations in the autonomously initiated periodic trains of calcium transients observed in cell bodies, which are independent of presynaptic inputs. C_elegans_phenotype_ontology WBPhenotype:0002024 cell body spike frequency variant Animals exhibit variations in the autonomously initiated periodic trains of calcium transients observed in cell bodies, which are independent of presynaptic inputs. WB:WBPaper00031592 WB:WBPerson712 The diameter, volume, or area taken up by a cell differs from that measured in control animals. C_elegans_phenotype_ontology WBPhenotype:0002025 cell size decreased The diameter, volume, or area taken up by a cell differs from that measured in control animals. WB:WBPaper00038069 WB:WBPerson712 Animals differ from control animals in response to mechanical stimulation targeting different parts of the same cell. In N2 wild-type animals, response to touch near the ALM cell body is reduced compared with touch of the cell area near the second pharyngeal bulb. C_elegans_phenotype_ontology WBPhenotype:0002026 differential touch sensitivity variant Animals differ from control animals in response to mechanical stimulation targeting different parts of the same cell. In N2 wild-type animals, response to touch near the ALM cell body is reduced compared with touch of the cell area near the second pharyngeal bulb. WB:WBPaper00040149 WB:WBPerson712 VPCs differentiate in the absence of inductive signals coming from the gonad. Gid C_elegans_phenotype_ontology WBPhenotype:0002027 gonad independent vulva differentiation VPCs differentiate in the absence of inductive signals coming from the gonad. WB:WBPaper00025001 WB:WBPaper00027764 WB:WBPerson712 Animals differ from controls in their electrical response to mechanical stimulus. C_elegans_phenotype_ontology MRC variant WBPhenotype:0002028 mechanoreceptor current variant Animals differ from controls in their electrical response to mechanical stimulus. WB:WBPaper00040149 WB:WBPerson712 Variations in the regulation of levels, transport, and metabolism of metal ions within an organism compared to control. C_elegans_phenotype_ontology WBPhenotype:0002029 metal homeostasis variant Variations in the regulation of levels, transport, and metabolism of metal ions within an organism compared to control. WB:WBPerson712 Variations in the regulation of levels, transport, and metabolism of magnesium ions within an organism compared to control. C_elegans_phenotype_ontology WBPhenotype:0002030 magnesium homeostasis variant Variations in the regulation of levels, transport, and metabolism of magnesium ions within an organism compared to control. GO:0010960 WB:WBPerson557 WB:WBPerson712 Exposure to carbohydrate binding gene products result in an altered action in comparison to controls. C_elegans_phenotype_ontology WBPhenotype:0002031 lectin response variant Exposure to carbohydrate binding gene products result in an altered action in comparison to controls. WB:WBPaper00038311 WB:WBPerson712 Animals differ from controls in the range, specificity, or presence of targets for exogenously applied lectins. C_elegans_phenotype_ontology WBPhenotype:0002032 lectin binding variant Animals differ from controls in the range, specificity, or presence of targets for exogenously applied lectins. WB:WBPaper00038311 WB:WBPerson712 Animals contain targets for exogenously applied lectins. C_elegans_phenotype_ontology ectopic lectin binding WBPhenotype:0002033 lectin binding occurs Animals contain targets for exogenously applied lectins. WB:WBPaper00038311 WB:WBPerson712 Animals are not observed to contain targets for exogenously applied lectins. C_elegans_phenotype_ontology WBPhenotype:0002034 lectin binding does not occur Animals are not observed to contain targets for exogenously applied lectins. WB:WBPaper00038311 WB:WBPerson712 Exposure to lectin has no affect on the behavior, growth, or development of the animal compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002035 resistant to lectin Exposure to lectin has no affect on the behavior, growth, or development of the animal compared to controls. WB:WBPaper00038311 WB:WBPerson712 Exposure to lectin results in altered behavior, growth, or development of the animal compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002036 susceptible to lectin Exposure to lectin results in altered behavior, growth, or development of the animal compared to controls. WB:WBPaper00038311 WB:WBPerson712 The appearance and association of components along the double lipid bilayer enclosing the nucleus differs from controls. The NE separates nuclear contents from the rest of the cytoplasm and includes the intermembrane space, perinuclear space. C_elegans_phenotype_ontology WBPhenotype:0002037 nuclear envelope organization variant The appearance and association of components along the double lipid bilayer enclosing the nucleus differs from controls. The NE separates nuclear contents from the rest of the cytoplasm and includes the intermembrane space, perinuclear space. WB:WBPaper00040620 WB:WBPerson712 Proteins show defects in their localization in the cilia compared to control animals. cil C_elegans_phenotype_ontology WBPhenotype:0002038 ciliary localization defective Proteins show defects in their localization in the cilia compared to control animals. WB:WBPaper00031689 Animals exhibit variation in the directed movement of organelles or molecules along microtubules from the cell periphery in nerve cell axons to the cell body, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002039 retrograde transport variant Animals exhibit variation in the directed movement of organelles or molecules along microtubules from the cell periphery in nerve cell axons to the cell body, compared to control. WB:WBPaper00038442 WB:WBPerson712 Chromosomes are not segregated symmetrically during mitosis. C_elegans_phenotype_ontology chaotic mitosis WBPhenotype:0002040 asymmetric chromosome segregation Chromosomes are not segregated symmetrically during mitosis. WB:WBPaper00038412 WB:WBPerson712 Animals exhibit variation in timing or ability to molt. C_elegans_phenotype_ontology WBPhenotype:0002041 molt variant Animals exhibit variation in timing or ability to molt. WB:WBPaper00040467 WB:WBPerson712 Molting cycles do not occur in a temporally controlled manner and cannot be synchronized across a population. C_elegans_phenotype_ontology WBPhenotype:0002042 molting arrhythmic Molting cycles do not occur in a temporally controlled manner and cannot be synchronized across a population. WB:WBPaper00040467 WB:WBPerson712 The number of cross progeny produced by hermaphrodites is reduced compared to control hermaphrodites. C_elegans_phenotype_ontology WBPhenotype:0002043 hermaphrodite mating efficiency reduced The number of cross progeny produced by hermaphrodites is reduced compared to control hermaphrodites. WB:WBPerson557 Hermaphrodites do not produce cross progeny. C_elegans_phenotype_ontology WBPhenotype:0002044 hermaphrodite mating efficiency eliminated Hermaphrodites do not produce cross progeny. WB:WBPerson557 Animals exhibit fewer cell corpses compared to controls at the same developmental life stage. C_elegans_phenotype_ontology WBPhenotype:0002045 cell corpse number decreased Animals exhibit fewer cell corpses compared to controls at the same developmental life stage. WB:WBPerson712 Variations in the regulation of levels, transport, and metabolism of iron within an organism compared to control. C_elegans_phenotype_ontology WBPhenotype:0002046 iron homeostasis variant Variations in the regulation of levels, transport, and metabolism of iron within an organism compared to control. GO:0055072 WB:WBPerson557 Animals exhibit variations in their response to muscimol compared to that observed in control animals. Muscimol is a GABA-A receptor agonist. C_elegans_phenotype_ontology WBPhenotype:0002047 muscimol response variant Animals exhibit variations in their response to muscimol compared to that observed in control animals. Muscimol is a GABA-A receptor agonist. WB:WBPaper00038249 WB:WBPerson712 Animals survive longer, or do not respond to the same degree as control animals under similar conditions of abamectin exposure. C_elegans_phenotype_ontology WBPhenotype:0002048 abamectin resistant Animals survive longer, or do not respond to the same degree as control animals under similar conditions of abamectin exposure. WB:WBPaper00040740 WB:WBPerson557 WB:WBPerson712 Animals are not affected to the same degree as control animals under similar conditions of abamectin exposure. C_elegans_phenotype_ontology WBPhenotype:0002049 abamectin repsonse variant Animals are not affected to the same degree as control animals under similar conditions of abamectin exposure. WB:WBPaper00040740 WB:WBPerson557 WB:WBPerson712 Animals are do not survive, or become paralyzed in the presence of abamectin. C_elegans_phenotype_ontology WBPhenotype:0002050 abamectin sensitive Animals are do not survive, or become paralyzed in the presence of abamectin. WB:WBPaper00040740 WB:WBPerson557 WB:WBPerson712 The production or regulation of ascaroside molecule populations differs from that of control animals. C_elegans_phenotype_ontology WBPhenotype:0002051 ascaroside biosynthesis variant The production or regulation of ascaroside molecule populations differs from that of control animals. WB:WBPaper00040624 WB:WBPerson712 Animals lack the ability to produce ascarosides that are capable of being produced in control animals. C_elegans_phenotype_ontology WBPhenotype:0002052 ascaroside biosynthesis defective Animals lack the ability to produce ascarosides that are capable of being produced in control animals. WB:WBPaper00040624 WB:WBPerson712 Animals fail to respond to or exhibit an attenuated response to ivermectin under conditions that elicits a response in control animals. C_elegans_phenotype_ontology WBPhenotype:0002053 ivermectin resistant Animals fail to respond to or exhibit an attenuated response to ivermectin under conditions that elicits a response in control animals. WB:WBPaper00003945 WB:WBPaper00040740 WB:WBPerson712 Animals exhibit an exaggerated response to magnesium compared to control animals exposed to similar concentrations. C_elegans_phenotype_ontology WBPhenotype:0002054 magnesium hypersensitivity Animals exhibit an exaggerated response to magnesium compared to control animals exposed to similar concentrations. WB:WBPaper00036046 WB:WBPerson712 Animals do not exhibit light-induced currrents to the same extent or with the same quality as control animals. C_elegans_phenotype_ontology WBPhenotype:0002055 photocurrent defective Animals do not exhibit light-induced currrents to the same extent or with the same quality as control animals. WB:WBPaper00036207 WB:WBPerson712 Any variation in the specific actions or reactions of an organism causing an alteration in the ingestion of food compared to control animals. In C. elegans the main food source is bacteria and alterations in eating behavior usually lead to malnutrition. Eat C_elegans_phenotype_ontology WBPhenotype:0002056 eating variant Any variation in the specific actions or reactions of an organism causing an alteration in the ingestion of food compared to control animals. In C. elegans the main food source is bacteria and alterations in eating behavior usually lead to malnutrition. WB:WBPerson557 WB:WBPerson712 Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002057 Bacillus thuringiensis toxin hypersensitive Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals are not affected to the same degree as control animals under similar conditions of pore forming toxin exposure. C_elegans_phenotype_ontology WBPhenotype:0002058 pore forming toxin response variant Animals are not affected to the same degree as control animals under similar conditions of pore forming toxin exposure. WB:WBPerson2987 WB:WBPerson557 Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls. Hpo hypersensitive to pore forming toxin C_elegans_phenotype_ontology WBPhenotype:0002059 pore forming toxin hypersensitive Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls. WB:WBPerson2987 WB:WBPerson557 Animals fail to respond to the concentration of pore forming toxins that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002060 pore forming toxin resistant Animals fail to respond to the concentration of pore forming toxins that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson2987 WB:WBPerson557 Any variation in the progressive decompaction of chromatin that changes chromosome structure from the condensed form to a relaxed disperse form. C_elegans_phenotype_ontology WBPhenotype:0002061 chromosome decondensation variant Any variation in the progressive decompaction of chromatin that changes chromosome structure from the condensed form to a relaxed disperse form. GO:0051312 WB:WBPerson2987 WB:WBPerson557 The process of decompaction of chromatin that changes chromosome structure from the condensed form to a relaxed disperse form is abolished. C_elegans_phenotype_ontology WBPhenotype:0002062 chromosome decondensation failure The process of decompaction of chromatin that changes chromosome structure from the condensed form to a relaxed disperse form is abolished. WB:WBPerson2987 WB:WBPerson557 Animals differ from controls in the expression of genes targeted for silencing (gene inactivation) in subsequent generations via transcriptional or post-transcriptional processes. C_elegans_phenotype_ontology WBPhenotype:0002063 maintenance of gene silencing variant Animals differ from controls in the expression of genes targeted for silencing (gene inactivation) in subsequent generations via transcriptional or post-transcriptional processes. GO:0016458 WB:WBPaper00041239 WB:WBPerson557 WB:WBPerson712 Animals express genes that had been targeted for heritable silencing in previous generations. C_elegans_phenotype_ontology WBPhenotype:0002064 maintenance of gene silencing defective Animals express genes that had been targeted for heritable silencing in previous generations. WB:WBPaper00041239 WB:WBPerson712 Animals display variations in the manner in which the basement membrane (a thin, dense, sheet-like structure built on a network of polymeric laminin and type IV collagen) is remodeled, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002065 basement membrane remodeling variant Animals display variations in the manner in which the basement membrane (a thin, dense, sheet-like structure built on a network of polymeric laminin and type IV collagen) is remodeled, compared to control animals. WB:WBPaper00038447 WB:WBPerson2987 WB:WBPerson557 Animals display variations in the manner in which an opening in the basement membrane (a thin, dense, sheet-like structure built on a network of polymeric laminin and type IV collagen) expands to make way for intertissue connections, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002066 basement membrane gap expansion variant Animals display variations in the manner in which an opening in the basement membrane (a thin, dense, sheet-like structure built on a network of polymeric laminin and type IV collagen) expands to make way for intertissue connections, compared to control animals. WB:WBPaper00038447 WB:WBPerson2987 WB:WBPerson557 Animals differ from control animals in cortical actomyocin dynamics leading to internalization of endodermal precursor cells during gastrulation. C_elegans_phenotype_ontology WBPhenotype:0002067 apical constriction variant Animals differ from control animals in cortical actomyocin dynamics leading to internalization of endodermal precursor cells during gastrulation. WB:WBPaper00040757 WB:WBPerson712 There is significantly less difference between the number of astral microtubles or other component(s) of the spindle microtuble organizing center at the anterior versus posterior poles of the spindle, than observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002068 astral microtubule asymmetry defective There is significantly less difference between the number of astral microtubles or other component(s) of the spindle microtuble organizing center at the anterior versus posterior poles of the spindle, than observed in control animals. WB:WBPaper00040200 WB:WBPerson712 Axons in animals do not end in the same manner as they do in control animals. Some defects described include an overextension of the axon or termination of the axon in the shape of a hook, either large or small. C_elegans_phenotype_ontology WBPhenotype:0002069 axon termination defective Axons in animals do not end in the same manner as they do in control animals. Some defects described include an overextension of the axon or termination of the axon in the shape of a hook, either large or small. WB:WBPaper00040220 WB:WBPerson712 Animals do not mimic control animals in their egg-laying response to muscimol exposure. In C. elegans, muscimol inhibits egg-laying. C_elegans_phenotype_ontology WBPhenotype:0002070 egg laying response to muscimol variant Animals do not mimic control animals in their egg-laying response to muscimol exposure. In C. elegans, muscimol inhibits egg-laying. WB:WBPaper00038249 WB:WBPerson712 The length of the animal does not increase to the same extent as observed for control animals, in response to exposure to muscimol. C_elegans_phenotype_ontology WBPhenotype:0002071 body lengthening response to muscimol variant The length of the animal does not increase to the same extent as observed for control animals, in response to exposure to muscimol. WB:WBPaper00038249 WB:WBPerson712 Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of carbohydrates within the organism or cell compared to control. C_elegans_phenotype_ontology WBPhenotype:0002072 carbohydrate metabolism variant Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of carbohydrates within the organism or cell compared to control. WB:WBPaper00038233 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in the regulation of levels, transport, and metabolism of cations within a cell or between a cell and its external environment, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002073 cation homeostasis variant Animals exhibit variations in the regulation of levels, transport, and metabolism of cations within a cell or between a cell and its external environment, compared to control. WB:WBPaper00036046 WB:WBPerson712 Animals vary in the directed or coordinated movement of their centrosomes during cell division, compared to the pattern of movement observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002074 centrosome dynamics variant Animals vary in the directed or coordinated movement of their centrosomes during cell division, compared to the pattern of movement observed in control animals. WB:WBPaper00040172 WB:WBPerson712 Embryos exhibit variations in the processes that lead to the construction of the eggshell, a protective structure that minimizes water loss whilst allowing gas exchanges essential for embryonic respiration, compared to controls C_elegans_phenotype_ontology WBPhenotype:0002075 eggshell formation variant Embryos exhibit variations in the processes that lead to the construction of the eggshell, a protective structure that minimizes water loss whilst allowing gas exchanges essential for embryonic respiration, compared to controls GO:0030703 WB:WBPaper00031064 WB:WBPaper00040142 WB:WBPerson557 WB:WBPerson712 The process of secretion by a cell that results in the release of intracellular molecules contained within a specialized secretory vesicle that fuses with the plasma membrane during egg activation. C_elegans_phenotype_ontology WBPhenotype:0002076 cortical granule exocytosis variant The process of secretion by a cell that results in the release of intracellular molecules contained within a specialized secretory vesicle that fuses with the plasma membrane during egg activation. GO:0060471 WB:WBPaper00031064 WB:WBPaper00040142 WB:WBPerson557 WB:WBPerson712 Animals fail to respond to the concentration of a dopamine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002077 dopamine resistant Animals fail to respond to the concentration of a dopamine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPaper00038270 WB:WBPerson557 WB:WBPerson712 The pattern or state of methyl modifications of histone varies from that of controls. C_elegans_phenotype_ontology methylation mark variant WBPhenotype:0002078 histone methylation variant The pattern or state of methyl modifications of histone varies from that of controls. WB:WBPaper00038409 WB:WBPerson712 The animal's ability to reproduce, or start of reproduction occurs later than that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0002079 delayed reproductive maturity The animal's ability to reproduce, or start of reproduction occurs later than that observed for control animals. WB:WBPerson712 Animals exhibit variations in the degree to which or manner in which an intestinal cell is able to uptake peptides (for example, di- or tripeptides) from the intestinal lumen, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002080 peptide uptake by intestinal cell variant Animals exhibit variations in the degree to which or manner in which an intestinal cell is able to uptake peptides (for example, di- or tripeptides) from the intestinal lumen, compared to control animals. WB:WBPerson2987 Animals exhibit an increase in the degree to which an intestinal cell is able to uptake peptides (for example, di- or tripeptides) from the intestinal lumen, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002081 peptide uptake by intestinal cell increased Animals exhibit an increase in the degree to which an intestinal cell is able to uptake peptides (for example, di- or tripeptides) from the intestinal lumen, compared to control animals. WB:WBPerson2987 Animals exhibit a decrease in the degree to which an intestinal cell is able to uptake peptides (for example, di- or tripeptides) from the intestinal lumen, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002082 peptide uptake by intestinal cell decreased Animals exhibit a decrease in the degree to which an intestinal cell is able to uptake peptides (for example, di- or tripeptides) from the intestinal lumen, compared to control animals. WB:WBPerson2987 The frequency and distribution of crossover events differs from that observed for controls. C_elegans_phenotype_ontology WBPhenotype:0002083 crossover variant The frequency and distribution of crossover events differs from that observed for controls. WB:WBPaper00037960 WB:WBPerson712 Animals differ from controls in respect to the frequency of expected double crossover events observed. C_elegans_phenotype_ontology WBPhenotype:0002084 crossover interference variant Animals differ from controls in respect to the frequency of expected double crossover events observed. WB:WBPaper00037960 WB:WBPerson712 The number of crossover events differs from that of observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002085 crossover formation variant The number of crossover events differs from that of observed in control animals. WB:WBPaper00037960 WB:WBPerson712 The location-specific frequency of crossover events differs from that of observed in control animals, while the total number of crossover events does not significantly differ. C_elegans_phenotype_ontology WBPhenotype:0002086 crossover distribution variant The location-specific frequency of crossover events differs from that of observed in control animals, while the total number of crossover events does not significantly differ. WB:WBPaper00037960 WB:WBPerson712 Animals respond to hydrogen sulfide at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002087 hydrogen sulfide hypersensitive Animals respond to hydrogen sulfide at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00039977 WB:WBPerson712 Animals respond to dauer pheromone at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002088 hypersensitive to dauer pheromone Animals respond to dauer pheromone at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson712 Any variation in the form or composition of the basic structural and functional components of cells compared to control. Includes the nucleus, endoplasmic reticulum, Golgi apparatus, mitochondria, endosomes, lysosomes, and peroxisomes as well as other vesicles and organelles. C_elegans_phenotype_ontology WBPhenotype:0002089 cell component morphology variant Any variation in the form or composition of the basic structural and functional components of cells compared to control. Includes the nucleus, endoplasmic reticulum, Golgi apparatus, mitochondria, endosomes, lysosomes, and peroxisomes as well as other vesicles and organelles. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the form or composition of membrane bound organelles, known as endosomes, that traffic material between the plasma membrane and internal compartments of the cell, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002090 endosome morphology variant Any variation in the form or composition of membrane bound organelles, known as endosomes, that traffic material between the plasma membrane and internal compartments of the cell, compared to control. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the form or composition of membrane bound organelles, known as late endosomes, that traffic material from early endosomes to internal compartments of the cell, such as lysosomes or the Golgi apparatus, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002091 late endosome morphology variant Any variation in the form or composition of membrane bound organelles, known as late endosomes, that traffic material from early endosomes to internal compartments of the cell, such as lysosomes or the Golgi apparatus, compared to control. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the form or composition of membrane bound organelles, known as early endosomes, that traffic material from endocytic vesicles (having recently internalized portions of the cell's plasma membrane) to internal compartments of the cell, such as recycling endosomes, late endosomes, or the Golgi apparatus, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002092 early endosome morphology variant Any variation in the form or composition of membrane bound organelles, known as early endosomes, that traffic material from endocytic vesicles (having recently internalized portions of the cell's plasma membrane) to internal compartments of the cell, such as recycling endosomes, late endosomes, or the Golgi apparatus, compared to control. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane. C_elegans_phenotype_ontology WBPhenotype:0002093 recycling endosome morphology variant Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane. C_elegans_phenotype_ontology WBPhenotype:0002094 RAB-11 recycling endosome morphology variant Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the form or composition of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002095 lysosome-related organelle morphology variant Any variation in the form or composition of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the form or composition of membrane bound organelles, known as the Golgi apparatus, that traffic material from the endoplasmic reticulum or various endosomes, and process proteins for secretion, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002096 golgi apparatus morphology variant Any variation in the form or composition of membrane bound organelles, known as the Golgi apparatus, that traffic material from the endoplasmic reticulum or various endosomes, and process proteins for secretion, compared to control. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the form or composition of membrane bound organelles, known as lysosomes, that have an acidic interior and generally act to digest components of the cell, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002097 lysosome morphology variant Any variation in the form or composition of membrane bound organelles, known as lysosomes, that have an acidic interior and generally act to digest components of the cell, compared to control. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the subcellular localization of the basic structural and functional components of cells compared to control. Includes the nucleus, endoplasmic reticulum, Golgi apparatus, mitochondria, endosomes, lysosomes, and peroxisomes as well as other vesicles and organelles. C_elegans_phenotype_ontology WBPhenotype:0002098 cell component localization variant Any variation in the subcellular localization of the basic structural and functional components of cells compared to control. Includes the nucleus, endoplasmic reticulum, Golgi apparatus, mitochondria, endosomes, lysosomes, and peroxisomes as well as other vesicles and organelles. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the subcellular localization of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002099 lysosome-related organelle localization variant Any variation in the subcellular localization of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the subcellular localization of membrane bound organelles, known as endosomes, that traffic material between the plasma membrane and internal compartments of the cell, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002100 endosome localization variant Any variation in the subcellular localization of membrane bound organelles, known as endosomes, that traffic material between the plasma membrane and internal compartments of the cell, compared to control. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the subcellular localization of the endoplasmic reticulum compared to control. The endoplasmic reticulum (ER) is an irregular network of membranes, that exists in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). C_elegans_phenotype_ontology WBPhenotype:0002101 endoplasmic reticulum localization variant Any variation in the subcellular localization of the endoplasmic reticulum compared to control. The endoplasmic reticulum (ER) is an irregular network of membranes, that exists in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). WB:WBPaper00041129 WB:WBPerson2987 Any variation in the subcellular localization of membrane bound organelles, known as the Golgi apparatus, that traffic material from the endoplasmic reticulum or various endosomes, and process proteins for secretion, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002102 golgi apparatus localization variant Any variation in the subcellular localization of membrane bound organelles, known as the Golgi apparatus, that traffic material from the endoplasmic reticulum or various endosomes, and process proteins for secretion, compared to control. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the subcellular localization of membrane bound organelles, known as lysosomes, that have an acidic interior and generally act to digest components of the cell, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002103 lysosome localization variant Any variation in the subcellular localization of membrane bound organelles, known as lysosomes, that have an acidic interior and generally act to digest components of the cell, compared to control. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane. C_elegans_phenotype_ontology WBPhenotype:0002104 recycling endosome localization variant Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the subcellular localization of membrane bound organelles, known as late endosomes, that traffic material from early endosomes to internal compartments of the cell, such as lysosomes or the Golgi apparatus, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002105 late endosome localization variant Any variation in the subcellular localization of membrane bound organelles, known as late endosomes, that traffic material from early endosomes to internal compartments of the cell, such as lysosomes or the Golgi apparatus, compared to control. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the subcellular localization of membrane bound organelles, known as early endosomes, that traffic material from endocytic vesicles (having recently internalized portions of the cell's plasma membrane) to internal compartments of the cell, such as recycling endosomes, late endosomes, or the Golgi apparatus, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002106 early endosome localization variant Any variation in the subcellular localization of membrane bound organelles, known as early endosomes, that traffic material from endocytic vesicles (having recently internalized portions of the cell's plasma membrane) to internal compartments of the cell, such as recycling endosomes, late endosomes, or the Golgi apparatus, compared to control. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane. C_elegans_phenotype_ontology WBPhenotype:0002107 RAB-11 recycling endosome localization variant Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the form or composition of specialized cell types, compared to control. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. C_elegans_phenotype_ontology WBPhenotype:0002108 cell type morphology variant Any variation in the form or composition of specialized cell types, compared to control. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. WB:WBPaper00041129 WB:WBPerson2987 Animals are affected by exposure to the drug. C_elegans_phenotype_ontology WBPhenotype:0002109 drug susceptible Animals are affected by exposure to the drug. WB:WBPerson712 Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the endocytosis protein RME-1, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane. C_elegans_phenotype_ontology WBPhenotype:0002110 RME-1 recycling endosome morphology variant Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the endocytosis protein RME-1, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane. WB:WBPaper00041129 WB:WBPerson2987 Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, positive for the endocytosis protein RME-1, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane. C_elegans_phenotype_ontology WBPhenotype:0002111 RME-1 recycling endosome localization variant Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, positive for the endocytosis protein RME-1, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane. WB:WBPaper00041129 WB:WBPerson2987 Animals are unable to maintain paired chromosome throughout pachytene. C_elegans_phenotype_ontology WBPhenotype:0002112 synapsis maintenance defective Animals are unable to maintain paired chromosome throughout pachytene. WB:WBPaper00037960 WB:WBPerson712 Animals differ from controls in respect to the formation of paired chromosome loci. C_elegans_phenotype_ontology WBPhenotype:0002113 synapsis formation variant Animals differ from controls in respect to the formation of paired chromosome loci. WB:WBPaper00037960 WB:WBPerson712 Animals become paralyzed after a measured amount of time swimming. In C. elegans, more then 80 percent of wild-type animals continue swimming vigorously in liquid even after 30 minutes. SWIP C_elegans_phenotype_ontology WBPhenotype:0002114 swimming induced paralysis Animals become paralyzed after a measured amount of time swimming. In C. elegans, more then 80 percent of wild-type animals continue swimming vigorously in liquid even after 30 minutes. WB:WBPaper00038270 WB:WBPerson712 Animals do not avoid, and perhaps seek, environments that result in their death. In the case of C. elegans, this behavior is exemplified by animals that tend to crawl off the plate. C_elegans_phenotype_ontology WBPhenotype:0002115 suicidal Animals do not avoid, and perhaps seek, environments that result in their death. In the case of C. elegans, this behavior is exemplified by animals that tend to crawl off the plate. WB:WBPerson712 Animals are barely alive, but not entirely dead. C_elegans_phenotype_ontology WBPhenotype:0002116 subviable Animals are barely alive, but not entirely dead. WB:WBPerson712 Animals exhibit constrictions in the anterior portion of the head that result in decapitation. C_elegans_phenotype_ontology WBPhenotype:0002117 occurences of decapitation Animals exhibit constrictions in the anterior portion of the head that result in decapitation. WB:WBPerson712 Populations exhibit variations in the ability to survive, grow and reproduce, thus affecting the contribution to the gene pool over generations compared to control populations. In C. elegans the fitness of a population can by assessed by measuring the rate at which E. coli is consumed. population fitness variant C_elegans_phenotype_ontology WBPhenotype:0002118 population fitness phenotype Populations exhibit variations in the ability to survive, grow and reproduce, thus affecting the contribution to the gene pool over generations compared to control populations. In C. elegans the fitness of a population can by assessed by measuring the rate at which E. coli is consumed. WB:WBPaper00040316 WB:WBPaper00040815 WB:WBPerson2987 WB:WBPerson557 The process of generating multiple mRNA molecules from differential use of exons in a primary transcript(s) does not occur or occurs with outcomes not observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002119 alternative splicing defective The process of generating multiple mRNA molecules from differential use of exons in a primary transcript(s) does not occur or occurs with outcomes not observed in control animals. WB:WBPerson1686 WB:WBPerson712 Any variation in the process of restoring mitochondrial DNA after damage. C_elegans_phenotype_ontology WBPhenotype:0002120 mitochondrial DNA repair variant Any variation in the process of restoring mitochondrial DNA after damage. GO:0043504 WB:WBPerson557 The presence of a mixture of more than one type of an organellar genome (mitochondrial DNA (mtDNA) or plastid DNA) within a cell or individual. C_elegans_phenotype_ontology WBPhenotype:0002121 heteroplasmy The presence of a mixture of more than one type of an organellar genome (mitochondrial DNA (mtDNA) or plastid DNA) within a cell or individual. WB:WBPaper00040387 WB:WBPerson2987 Mitochondria from spermatazoa persist in the developing embryo and animal as a result of bypassing the degradation mechanism that normally destroys paternal mitochondria immediately after fertilization. This can often lead to a form of heteroplasmy. C_elegans_phenotype_ontology WBPhenotype:0002122 persistence of paternal mitochondria Mitochondria from spermatazoa persist in the developing embryo and animal as a result of bypassing the degradation mechanism that normally destroys paternal mitochondria immediately after fertilization. This can often lead to a form of heteroplasmy. WB:WBPaper00040387 WB:WBPerson2987 The pattern or state of acetylation modifications of histones varies from that of controls. C_elegans_phenotype_ontology WBPhenotype:0002123 histone acetylation variant The pattern or state of acetylation modifications of histones varies from that of controls. WB:WBPaper00040843 WB:WBPerson2987 The distribution or presence of actin in circumferential actin bundles (CFB) differs from that observed in control animals. Contraction of CFBs provide the driving force for epidermal elongation. C_elegans_phenotype_ontology WBPhenotype:0002124 circumferential actin bundles disorganized The distribution or presence of actin in circumferential actin bundles (CFB) differs from that observed in control animals. Contraction of CFBs provide the driving force for epidermal elongation. WB:WBPaper00006290 WB:WBPerson712 Animals do not grow fast or the quality of growth is decreased when exposed to a specific chemical compound when compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002125 growth inhibition response to chemical Animals do not grow fast or the quality of growth is decreased when exposed to a specific chemical compound when compared to control animals. WB:WBPaper00040519 WB:WBPerson712 Animals exhibit a decrease in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine. C_elegans_phenotype_ontology WBPhenotype:0002126 intestinal fluorescence decreased Animals exhibit a decrease in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine. WB:WBPerson712 Animals exhibit variation rate of directed movement of organelles or molecules along microtubules in nerve cell axons, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002127 intraflagellar transport velocity variant Animals exhibit variation rate of directed movement of organelles or molecules along microtubules in nerve cell axons, compared to control. WB:WBPaper00038442 WB:WBPerson712 Males remain on food in the absence of mates, a defect in male mate-searching behavior observed in control males. Las C_elegans_phenotype_ontology WBPhenotype:0002128 leaving assay defective Males remain on food in the absence of mates, a defect in male mate-searching behavior observed in control males. WB:WBPaper00041718 WB:WBPerson712 Relative levels of mtDNA differ from that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0002129 mitochondrial DNA copy number variant Relative levels of mtDNA differ from that observed for control animals. WB:WBPaper00032112 WB:WBPerson712 Males exhibit variations of the behaviors observed in control animals that follow the completion of mating. C_elegans_phenotype_ontology mate experience variant WBPhenotype:0002130 post mating variant Males exhibit variations of the behaviors observed in control animals that follow the completion of mating. WB:WBPaper00041718 WB:WBPerson712 Animals display variations in the structure or organization of the components of the muscle, compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002131 muscle cell ultrastructure variant Animals display variations in the structure or organization of the components of the muscle, compared to that observed in control animals. WB:WBPerson712 The formation, organization, or stability of a protein complex is altered in comparison to corresponding complexes in control animals. C_elegans_phenotype_ontology protein clustering variant WBPhenotype:0002132 protein complex organization variant The formation, organization, or stability of a protein complex is altered in comparison to corresponding complexes in control animals. WB:WBPaper00038066 WB:WBPerson712 The bulk flow of cytoplasm in the egg, that facilitates mixing of ooplasm, occurs at a reduced rate compared to that measured for controls. C_elegans_phenotype_ontology WBPhenotype:0002133 ooplasmic streaming slow The bulk flow of cytoplasm in the egg, that facilitates mixing of ooplasm, occurs at a reduced rate compared to that measured for controls. WB:WBPerson712 Animals are less successful than controls in evading predators during predator-prey interactions. C_elegans_phenotype_ontology WBPhenotype:0002134 predator escape defective Animals are less successful than controls in evading predators during predator-prey interactions. WB:WBPaper00039982 WB:WBPerson712 Predator-prey interactions differ from that observed in control interactions. C_elegans_phenotype_ontology WBPhenotype:0002135 organism predator response variant Predator-prey interactions differ from that observed in control interactions. WB:WBPaper00039982 WB:WBPerson712 Animals are missing the anchor cell. In C. elegans the anchor cell is a key organizer of vulval patterning and morphogenesis. C_elegans_phenotype_ontology WBPhenotype:0002136 no anchor cell Animals are missing the anchor cell. In C. elegans the anchor cell is a key organizer of vulval patterning and morphogenesis. WB:WBPaper00003577 WB:WBPerson2987 WB:WBPerson557 The rate of the process preceding formation of the peptide bond between the first two amino acids of a protein is reduced. This process includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. Increase in free ribosomes (monosomes) are indicative of reduced translation initiation. C_elegans_phenotype_ontology WBPhenotype:0002137 reduced translation initiation The rate of the process preceding formation of the peptide bond between the first two amino acids of a protein is reduced. This process includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. Increase in free ribosomes (monosomes) are indicative of reduced translation initiation. GO:0006413 WB:WBPaper00039835 WB:WBPerson557 Animals are altered in their capacity to survive a normally lethal temperature treatment as a consequence of pretreatment at an elevated but sublethal temperature. C_elegans_phenotype_ontology WBPhenotype:0002138 acquired thermotolerance variant Animals are altered in their capacity to survive a normally lethal temperature treatment as a consequence of pretreatment at an elevated but sublethal temperature. WB:WBPaper00040849 WB:WBPerson557 Any variation in the morphological appearance of the linker cell compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002139 linker cell morphology variant Any variation in the morphological appearance of the linker cell compared to control animals. WB:WBPaper00035457 WB:WBPerson557 Males do not respond to small molecules or compounds that have been shown to attract control males. This phenotype is often measured by an increase in reversal frequency or time spent in a specified scoring region C_elegans_phenotype_ontology WBPhenotype:0002140 male attraction response variant Males do not respond to small molecules or compounds that have been shown to attract control males. This phenotype is often measured by an increase in reversal frequency or time spent in a specified scoring region WB:WBPaper00032050 WB:WBPerson712 Variations in the process of gaseous oxygen intake between an organism and its environment compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002141 oxygen consumption variant Variations in the process of gaseous oxygen intake between an organism and its environment compared to control animals. WB:WBPaper00042217 WB:WBPerson557 The activity, composition, or organization of the complexes of the electron transport chain, embedded in the inner mitochondrial membrane, differ from controls. MRC variant mitochondrial electron transport chain variant C_elegans_phenotype_ontology WBPhenotype:0002142 mitochondrial respiratory chain variant The activity, composition, or organization of the complexes of the electron transport chain, embedded in the inner mitochondrial membrane, differ from controls. GO:0005746 WB:WBPaper00042217 WB:WBPerson712 The part of the respiratory chain that catalyzes the oxidation of succinate and connects the TCA cycle with the respiratory chain, differs in activity, composition, or organization, from that of controls. CO II variant Complex II variant Succinate dehydrogenase complex variant C_elegans_phenotype_ontology WBPhenotype:0002143 mitochondrial respiratory complex II variant The part of the respiratory chain that catalyzes the oxidation of succinate and connects the TCA cycle with the respiratory chain, differs in activity, composition, or organization, from that of controls. GO:0045273 WB:WBPaper00042217 WB:WBPerson712 The protein complex located in the mitochondrial inner membrane that is the first entry point for electrons into the electron transport chain and catalyzes proton translocation coupled to the oxidation of NADH by ubiquinone, differs in activity, composition, or organization from that of controls. CO I variant Complex I variant NADH dehydrogenase complex variant Ubiquinone complex variant C_elegans_phenotype_ontology WBPhenotype:0002144 mitochondrial respiratory complex I variant The protein complex located in the mitochondrial inner membrane that is the first entry point for electrons into the electron transport chain and catalyzes proton translocation coupled to the oxidation of NADH by ubiquinone, differs in activity, composition, or organization from that of controls. GO:0005747 WB:WBPaper00042217 WB:WBPerson712 Animals are unable to produce or maintain short interfering RNA (siRNA) from double stranded RNA (dsRNA). siRNAs are required to initiate interference of gene expression. C_elegans_phenotype_ontology WBPhenotype:0002145 siRNA processing defective Animals are unable to produce or maintain short interfering RNA (siRNA) from double stranded RNA (dsRNA). siRNAs are required to initiate interference of gene expression. WB:WBPaper00027057 WB:WBPerson712 Animals exhibit variations from controls in the expression, biogenesis, processing, or stability of any class of small RNA species in the germline. Small RNAs include microRNAs (miRNAs), tiny noncoding RNAs (tncRNAs), cluster of small X-chromosome derived RNAs (X cluster), and endogenous short interfering RNA (endo-siRNAs). C_elegans_phenotype_ontology WBPhenotype:0002146 small RNA germline expression variant Animals exhibit variations from controls in the expression, biogenesis, processing, or stability of any class of small RNA species in the germline. Small RNAs include microRNAs (miRNAs), tiny noncoding RNAs (tncRNAs), cluster of small X-chromosome derived RNAs (X cluster), and endogenous short interfering RNA (endo-siRNAs). WB:WBPaper00027057 WB:WBPerson712 Animals exhibit variations from controls in the expression, biogenesis, processing, or stability of any class of small RNA species in somatic cells. Small RNAs include microRNAs (miRNAs), tiny noncoding RNAs (tncRNAs), cluster of small X-chromosome derived RNAs (X cluster), and endogenous short interfering RNA (endo-siRNAs). C_elegans_phenotype_ontology WBPhenotype:0002147 small RNA somatic expression variant Animals exhibit variations from controls in the expression, biogenesis, processing, or stability of any class of small RNA species in somatic cells. Small RNAs include microRNAs (miRNAs), tiny noncoding RNAs (tncRNAs), cluster of small X-chromosome derived RNAs (X cluster), and endogenous short interfering RNA (endo-siRNAs). WB:WBPaper00027057 WB:WBPerson712 Animals show reduced susceptibility to gene silencing in somatic cells triggered by double stranded RNA (dsRNA), compared to control. C_elegans_phenotype_ontology WBPhenotype:0002148 somatic RNAi resistant Animals show reduced susceptibility to gene silencing in somatic cells triggered by double stranded RNA (dsRNA), compared to control. WB:WBPaper00027057 WB:WBPerson712 Animals exhibit variations from controls in the expression, biogenesis, processing, or stability of the small X-chromosome derived RNAs (X cluster) species of small RNA. C_elegans_phenotype_ontology WBPhenotype:0002149 X cluster small RNA expression variant Animals exhibit variations from controls in the expression, biogenesis, processing, or stability of the small X-chromosome derived RNAs (X cluster) species of small RNA. WB:WBPaper00027057 WB:WBPerson712 RNAi silencing mechanisms triggered by exogenously introduced (foreign) dsRNA, do not work to the same degree as in control animals. C_elegans_phenotype_ontology WBPhenotype:0002150 exo-RNAi response variant RNAi silencing mechanisms triggered by exogenously introduced (foreign) dsRNA, do not work to the same degree as in control animals. WB:WBPaper00027057 WB:WBPerson712 Animals exhibit variations in the extent to which polyadenylated mRNA transcripts become deadenylated C_elegans_phenotype_ontology WBPhenotype:0002151 mRNA deadenylation variant Animals exhibit variations in the extent to which polyadenylated mRNA transcripts become deadenylated WB:WBPaper00037823 WB:WBPerson2987 Programmed cell death of germ cells caused by exposure to physical or chemical DNA-damaging agents does not occur to the same extent as it does in control animals. C_elegans_phenotype_ontology WBPhenotype:0002152 mutagen induced apoptosis variant Programmed cell death of germ cells caused by exposure to physical or chemical DNA-damaging agents does not occur to the same extent as it does in control animals. WB:WBPerson712 The production of silencing RNA from dsRNA is significantly deficient compared to controls. Deficiencies in this process can result in a defective RNAi response compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002153 dsRNA processing defective The production of silencing RNA from dsRNA is significantly deficient compared to controls. Deficiencies in this process can result in a defective RNAi response compared to controls. WB:WBPaper00029211 WB:WBPerson712 The extent of mRNA ribosome associations varies from controls. C_elegans_phenotype_ontology WBPhenotype:0002154 polysome mRNA association variant The extent of mRNA ribosome associations varies from controls. WB:WBPaper00032489 WB:WBPerson712 The production of mature miRNA from pre-miRNA is significantly deficient compared to controls. Deficiencies in this process can result in the accumulation of pre-miRNA species and or the absence or smaller amount of mature miRNA compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002155 pre miRNA processing defective The production of mature miRNA from pre-miRNA is significantly deficient compared to controls. Deficiencies in this process can result in the accumulation of pre-miRNA species and or the absence or smaller amount of mature miRNA compared to controls. WB:WBPaper00029211 WB:WBPerson712 Wild-type animals will exhibit an altered temperature preference based on food/temperature conditioning. Temperature learning variants do not exhibit altered responses to temperature after conditioning compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002156 temperature learning variant Wild-type animals will exhibit an altered temperature preference based on food/temperature conditioning. Temperature learning variants do not exhibit altered responses to temperature after conditioning compared to control animals. WB:WBPaper00031647 WB:WBPerson712 The extent of translational repression varies from controls. WBPhenotype:0001909 translational repression variant C_elegans_phenotype_ontology WBPhenotype:0002157 translation repression variant The extent of translational repression varies from controls. WB:WBPaper00032489 WB:WBPerson712 The selective elimination of P granule components and subsequent aggregation of degraded components into PGL granules is disrupted. C_elegans_phenotype_ontology WBPhenotype:0002158 P granule degradation defective The selective elimination of P granule components and subsequent aggregation of degraded components into PGL granules is disrupted. WB:WBPaper00044350 WB:WBPerson712 Animals exhibit an increase in pathogen accumulation, persistent colonization, and luminal distension of the intestine. C_elegans_phenotype_ontology WBPhenotype:0002159 increased pathogen accumulation Animals exhibit an increase in pathogen accumulation, persistent colonization, and luminal distension of the intestine. WB:WBPaper00032276 WB:WBPerson2987 The intracellular complex of proteins that participates in bidirectional transport of molecules (cargo) along axonemal microtubules is not made up of or does not maintain the proper number or ratio of components as found in control animals. C_elegans_phenotype_ontology WBPhenotype:0002160 intraflagellar transport complex destabilized The intracellular complex of proteins that participates in bidirectional transport of molecules (cargo) along axonemal microtubules is not made up of or does not maintain the proper number or ratio of components as found in control animals. WB:WBPaper00042072 WB:WBPerson712 Animals exhibit variations from controls in the organization of chromatin, including in relation to associated complexes, that occur during the mitotic cell division cycle. C_elegans_phenotype_ontology WBPhenotype:0002161 mitotic chromatin remodeling variant Animals exhibit variations from controls in the organization of chromatin, including in relation to associated complexes, that occur during the mitotic cell division cycle. GO:0006338 WB:WBPaper00040620 WB:WBPerson712 Cells exhibit mitotic spindles with more than two poles. C_elegans_phenotype_ontology multipolar mitosis WBPhenotype:0002162 multipolar mitotic spindle Cells exhibit mitotic spindles with more than two poles. WB:WBPaper00038412 WB:WBPerson712 Animals exhibit a decreased rate of oxygen utilization compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002163 oxygen consumption decreased Animals exhibit a decreased rate of oxygen utilization compared to control animals. WB:WBPaper00036073 WB:WBPerson712 Animals exhibit variations in their defense responses that are mediated by germline encoded components that directly recognize components of potential pathogens. C_elegans_phenotype_ontology WBPhenotype:0002164 innate immune response variant Animals exhibit variations in their defense responses that are mediated by germline encoded components that directly recognize components of potential pathogens. GO:0045087 WB:WBPerson557 The extent or other quality of the excitatory postsynaptic potential (EPSP) induced by in vitro stimuli differs from that of controls. C_elegans_phenotype_ontology WBPhenotype:0002165 muscle excitability variant The extent or other quality of the excitatory postsynaptic potential (EPSP) induced by in vitro stimuli differs from that of controls. WB:WBPaper00038066 WB:WBPerson712 The difference in electrical potential between the interior and the exterior of the muscle cell either in the resting state or during evoked stimulation differs from controls. C_elegans_phenotype_ontology WBPhenotype:0002166 muscle membrane potential variant The difference in electrical potential between the interior and the exterior of the muscle cell either in the resting state or during evoked stimulation differs from controls. WB:WBPaper00039987 WB:WBPerson712 The amount of histone methylation, for example as measured by the amount of H3K4me2, increases over successive generations C_elegans_phenotype_ontology generational accumulation of histone methylation progressive accumulation of histone methylation transgenerational epigenetic accumulation of histone methylation WBPhenotype:0002167 transgenerational accumulation of histone methylation The amount of histone methylation, for example as measured by the amount of H3K4me2, increases over successive generations WB:WBPaper00045092 WB:WBPerson712 Animals exhibit a decline in fertility over generations. This is often assessed by counting laid eggs over successive generations. C_elegans_phenotype_ontology generational loss of fertility progressive loss of fertility transgenerational epigenetic loss of fertility WBPhenotype:0002168 transgenerational loss of fertility Animals exhibit a decline in fertility over generations. This is often assessed by counting laid eggs over successive generations. WB:WBPaper00045092 WB:WBPerson712 Animals stop producing progeny significantly before the time reproduction stops in control animals. C_elegans_phenotype_ontology WBPhenotype:0002169 reproductive longevity shortened Animals stop producing progeny significantly before the time reproduction stops in control animals. WB:WBPaper00027157 WB:WBPerson2987 Any variation in the series of molecular signals in which a cell or tissue uses calcium ions to convert a signal into a response, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002170 calcium mediated signaling variant Any variation in the series of molecular signals in which a cell or tissue uses calcium ions to convert a signal into a response, compared to control. WB:WBPerson557 Animals exhibit variations in the characteristic movement towards typically attractive alkaline pH (pH higher than 7) compared to control. However animals tend to avoid very high pH levels (pH11). pH is a measure of the acidity or basicity of an aqueous solution. In C. elegans animals chemotax toward higher alkaline pH. C_elegans_phenotype_ontology alkaline pH sensing variant alkalinity sensing variant WBPhenotype:0002171 alkaline pH chemotaxis variant Animals exhibit variations in the characteristic movement towards typically attractive alkaline pH (pH higher than 7) compared to control. However animals tend to avoid very high pH levels (pH11). pH is a measure of the acidity or basicity of an aqueous solution. In C. elegans animals chemotax toward higher alkaline pH. GO:0036176 WB:WBPaper00042397 WB:WBPerson557 Infected animals exhibit variations in the process of releasing pathogens back into the environment, compared to control. spore shedding variant C_elegans_phenotype_ontology WBPhenotype:0002172 pathogen release variant Infected animals exhibit variations in the process of releasing pathogens back into the environment, compared to control. WB:WBPaper00040246 WB:WBPerson2987 Animals exhibit variations in the number of cells that make up the organism compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002173 cell number variant Animals exhibit variations in the number of cells that make up the organism compared to control animals. WB:WBPaper00032029 WB:WBPerson2987 The number of cells in the organism is reduced compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002174 cell number decreased The number of cells in the organism is reduced compared to control animals. WB:WBPaper00032029 WB:WBPerson2987 The number of cells in the organism is increased compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002175 cell number increased The number of cells in the organism is increased compared to control animals. WB:WBPaper00032029 WB:WBPerson2987 Animals exhibit variations in the structure, organization or placement of the population of the lateral, alae-producing epithelial cells (seam cells), compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002176 seam cell morphology variant Animals exhibit variations in the structure, organization or placement of the population of the lateral, alae-producing epithelial cells (seam cells), compared to that observed in control animals. WB:WBPaper00032029 WB:WBPerson2987 Any variation in the components that make up the semipermeable bilayer surrounding a cell that separates the cell from its external environment compared to control. C_elegans_phenotype_ontology WBPhenotype:0002177 plasma membrane composition variant Any variation in the components that make up the semipermeable bilayer surrounding a cell that separates the cell from its external environment compared to control. GO:0005886 WB:WBPerson2987 WB:WBPerson557 Any variation in the components that make up either of the two leaflets of the semipermeable bilayer surrounding a cell that separates the cell from its external environment compared to control. C_elegans_phenotype_ontology WBPhenotype:0002178 plasma membrane leaflet composition variant Any variation in the components that make up either of the two leaflets of the semipermeable bilayer surrounding a cell that separates the cell from its external environment compared to control. GO:0009897 GO:0009898 WB:WBPerson2987 WB:WBPerson557 Animals do not arrest mitotic germ cell division, as control animals, when treated with X-ray radiation. C_elegans_phenotype_ontology WBPhenotype:0002179 X ray induced mitotic germ cell arrest defective Animals do not arrest mitotic germ cell division, as control animals, when treated with X-ray radiation. WB:WBPaper00004952 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in the process by which cells having undergone programmed cell death are shed or extruded into the extracellular environment. C_elegans_phenotype_ontology WBPhenotype:0002180 apoptotic cell shedding variant Animals exhibit variations in the process by which cells having undergone programmed cell death are shed or extruded into the extracellular environment. WB:WBPaper00041303 WB:WBPerson2987 Animals produce an excess number of excretory cells compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002181 extra excretory cells Animals produce an excess number of excretory cells compared to controls. WB:WBPaper00041303 WB:WBPerson2987 Animals exhibit variations in endogenous levels of reactive oxygen species (chemically reactive molecules containing oxygen) compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002182 reactive oxygen species homeostasis variant Animals exhibit variations in endogenous levels of reactive oxygen species (chemically reactive molecules containing oxygen) compared to that observed in control animals. WB:WBPaper00042351 WB:WBPerson2987 Animals exhibit variations in levels of DNA damage caused by oxidative stress. C_elegans_phenotype_ontology WBPhenotype:0002183 oxidative DNA damage variant Animals exhibit variations in levels of DNA damage caused by oxidative stress. WB:WBPaper00042351 WB:WBPerson2987 Any variation in the amount of cells undergoing apoptosis in organism as a result of deprivation of nourishment, compared to control. In C. elegans, starvation normally causes increased apoptosis. C_elegans_phenotype_ontology WBPhenotype:0002184 starvation induced apoptosis variant Any variation in the amount of cells undergoing apoptosis in organism as a result of deprivation of nourishment, compared to control. In C. elegans, starvation normally causes increased apoptosis. WB:WBPaper00044006 WB:WBPerson557 Animals develop endodermal cells/tissue from precursor cells that do not normally produce endodermal cells/tissue. C_elegans_phenotype_ontology WBPhenotype:0002185 cell fate transformation to endoderm Animals develop endodermal cells/tissue from precursor cells that do not normally produce endodermal cells/tissue. WB:WBPaper00003645 WB:WBPerson2987 Animals develop pharyngeal muscles from precursor cells that do not normally produce pharyngeal muscles. C_elegans_phenotype_ontology WBPhenotype:0002186 cell fate transformation to pharyngeal muscle Animals develop pharyngeal muscles from precursor cells that do not normally produce pharyngeal muscles. WB:WBPaper00003645 WB:WBPerson2987 Animals develop body wall muscle from precursor cells that do not normally produce body wall muscle. C_elegans_phenotype_ontology WBPhenotype:0002187 cell fate transformation to body wall muscle Animals develop body wall muscle from precursor cells that do not normally produce body wall muscle. WB:WBPaper00003574 WB:WBPaper00003645 WB:WBPerson2987 Any variation in the progression of the components of the male gonad that are separate from the germline proper over time, from its formation to its mature structure compared to control. In C. elegans, the male somatic gonad consists of three tissues: distal tip cells (DTCs), the seminal vesicle, and the vas deferens (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0002188 male somatic gonad development variant Any variation in the progression of the components of the male gonad that are separate from the germline proper over time, from its formation to its mature structure compared to control. In C. elegans, the male somatic gonad consists of three tissues: distal tip cells (DTCs), the seminal vesicle, and the vas deferens (Wormatlas). WB:WBPerson2987 WB:WBPerson557 Animals produce an excess number of linker cells compared to controls. excess linker cells C_elegans_phenotype_ontology WBPhenotype:0002189 extra linker cells Animals produce an excess number of linker cells compared to controls. WB:WBPaper00005116 WB:WBPerson2987 The population of hypodermal cells is reduced compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002190 fewer hypodermal cells The population of hypodermal cells is reduced compared to control animals. WB:WBPerson557 Animals produce a reduced number of sex myoblasts compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002191 fewer sex myoblasts Animals produce a reduced number of sex myoblasts compared to controls. WB:WBPaper00033137 WB:WBPerson2987 Animals produce an excess number of sex myoblasts compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002192 extra sex myoblasts Animals produce an excess number of sex myoblasts compared to controls. WB:WBPaper00033137 WB:WBPerson2987 The orientation of the progeny of P7.p mimic those of P5.p and face towards the posterior of the worm, a phenotype referred to as posterior-reversed vulval lineage (P-Rvl). P-Rvl C_elegans_phenotype_ontology WBPhenotype:0002193 posterior reversed vulval lineage The orientation of the progeny of P7.p mimic those of P5.p and face towards the posterior of the worm, a phenotype referred to as posterior-reversed vulval lineage (P-Rvl). WB:WBPaper00044058 WB:WBPerson557 Animals do not differ in size when grown on different food sources to the same extent as that measured for control animals. For example, in C. elegans, wild type worms are 1.65 times larger when grown on HB101 compared to those grown on OP50. C_elegans_phenotype_ontology WBPhenotype:0002194 food dependent body size variant Animals do not differ in size when grown on different food sources to the same extent as that measured for control animals. For example, in C. elegans, wild type worms are 1.65 times larger when grown on HB101 compared to those grown on OP50. WB:WBPaper00038311 WB:WBPerson712 Animals exhibit variations in growth rate or the outcome of growth in response to food compared to control. In C. elegans, animals exhibit an increase or decrease in growth rate depending on the type of bacteria they are fed. C_elegans_phenotype_ontology WBPhenotype:0002195 food dependent growth variant Animals exhibit variations in growth rate or the outcome of growth in response to food compared to control. In C. elegans, animals exhibit an increase or decrease in growth rate depending on the type of bacteria they are fed. WB:WBPaper00038311 WB:WBPerson712 The driving force of the outward flow of ions does not exceed the inward flow for the opposite driving force or is otherwise altered when compared to that measured for control animals. C_elegans_phenotype_ontology WBPhenotype:0002196 outward rectifying current variant The driving force of the outward flow of ions does not exceed the inward flow for the opposite driving force or is otherwise altered when compared to that measured for control animals. WB:WBPaper00036046 WB:WBPerson712 Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded is altered from that observed for controls. C_elegans_phenotype_ontology WBPhenotype:0002197 voltage gated channel activity variant Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded is altered from that observed for controls. WB:WBPerson712 The proper localization and assembly of components at the junction of a neuron with a muscle cell varies from that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002198 neuromuscular junction organization variant The proper localization and assembly of components at the junction of a neuron with a muscle cell varies from that observed in control animals. WB:WBPaper00038066 WB:WBPerson712 The degree of stimulus-evoked calcium concentration changes differs from that of controls. C_elegans_phenotype_ontology WBPhenotype:0002199 neuron calcium transient levels variant The degree of stimulus-evoked calcium concentration changes differs from that of controls. WB:WBPaper00039855 WB:WBPerson712 Variations in the progression of the muscles of the adult hermaphrodite oviduct over time from their initial formation to their mature structure compared to control. C_elegans_phenotype_ontology WBPhenotype:0002200 oviduct muscle defective Variations in the progression of the muscles of the adult hermaphrodite oviduct over time from their initial formation to their mature structure compared to control. WB:WBPerson712 Dying animals cells exhibit defects in the fragmentation of chromosomal DNA into oligonucleosomal-length fragments compared to control animals. This process can be monitored by the quantity and quality of TUNEL (TdT-mediated dUTP nick end labeling)-positive nuclei. C_elegans_phenotype_ontology WBPhenotype:0002201 apoptotic DNA degradation defective Dying animals cells exhibit defects in the fragmentation of chromosomal DNA into oligonucleosomal-length fragments compared to control animals. This process can be monitored by the quantity and quality of TUNEL (TdT-mediated dUTP nick end labeling)-positive nuclei. WB:WBPaper00005978 WB:WBPerson712 Embryos exhibit defects in the extension of pharyngeal cells toward the buccal opening during embryogenesis compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002202 pharynx extension defective Embryos exhibit defects in the extension of pharyngeal cells toward the buccal opening during embryogenesis compared to controls. WB:WBPaper00005085 WB:WBPerson712 Corpses resulting from programmed cell death appear different in size or shape from those of corpses in control animals. C_elegans_phenotype_ontology WBPhenotype:0002203 corpse morphology variant Corpses resulting from programmed cell death appear different in size or shape from those of corpses in control animals. WB:WBPaper00004688 WB:WBPerson712 Animals exhibit defects in the muscle contractions of the anterior region of corpus, the area responsible for allowing food to enter the corpus. C_elegans_phenotype_ontology WBPhenotype:0002204 procorpus contraction defective Animals exhibit defects in the muscle contractions of the anterior region of corpus, the area responsible for allowing food to enter the corpus. WB:WBPaper00005996 WB:WBPerson712 Animals exhibit negative effects on growth, development, or metabolism when exposed to a galactose-rich diet, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002205 hypersensitive to galactose Animals exhibit negative effects on growth, development, or metabolism when exposed to a galactose-rich diet, compared to control animals. WB:WBPaper00045849 WB:WBPerson712 Animals process dietary galactose differently than control animals, these differences can result in increased and or decreased levels of intermediary galactose metabolites. C_elegans_phenotype_ontology WBPhenotype:0002206 galactose metabolism variant Animals process dietary galactose differently than control animals, these differences can result in increased and or decreased levels of intermediary galactose metabolites. WB:WBPaper00045849 WB:WBPerson712 Animals are missing one or both gonad arms, the normally U-shaped projections of the gonad that extend into the anterior or posterior of the animal and bends back towards the center of the animal. C_elegans_phenotype_ontology WBPhenotype:0002207 missing gonad arms Animals are missing one or both gonad arms, the normally U-shaped projections of the gonad that extend into the anterior or posterior of the animal and bends back towards the center of the animal. WB:WBPaper00003453 WB:WBPerson2987 The expression of a protein, as determined by antibody staining, varied from controls with respect to timing such that the protein was observed to be expressed at earlier timepoints or later timepoints than controls. C_elegans_phenotype_ontology WBPhenotype:0002208 antibody temporal expression variant The expression of a protein, as determined by antibody staining, varied from controls with respect to timing such that the protein was observed to be expressed at earlier timepoints or later timepoints than controls. WB:WBPaper00003383 WB:WBPerson2987 Any variation in the development of the structure that lies on the ventral surface just anterior and central to the base of the spicule openings (small lump on the gubernaculum of the male tail) and contains a sensory structure called the hook sensillum, compared to control. In C. elegans the hook is necessary for proper male mating. C_elegans_phenotype_ontology WBPhenotype:0002209 hook development variant Any variation in the development of the structure that lies on the ventral surface just anterior and central to the base of the spicule openings (small lump on the gubernaculum of the male tail) and contains a sensory structure called the hook sensillum, compared to control. In C. elegans the hook is necessary for proper male mating. WB:WBPaper00003428 WB:WBPerson2987 Animals exhibit an extra number of the finger-like sensory sensilla that project from the tail and embed in the male fan. C_elegans_phenotype_ontology WBPhenotype:0002210 extra rays Animals exhibit an extra number of the finger-like sensory sensilla that project from the tail and embed in the male fan. WB:WBPaper00003428 WB:WBPerson2987 Animals exhibit defects in dye-filling of the neuronal cells of the phasmid sensilla. In C. elegans, these neurons are commonly assayed by dye-filling with FITC, DiI or DiO. C_elegans_phenotype_ontology WBPhenotype:0002211 phasmid neuron dye filling defect Animals exhibit defects in dye-filling of the neuronal cells of the phasmid sensilla. In C. elegans, these neurons are commonly assayed by dye-filling with FITC, DiI or DiO. WB:WBPaper00003450 WB:WBPerson2987 WB:WBPerson557 Animals exhibit defects in dye-filling of the neuronal cells of the amphid sensilla. In C. elegans, these neurons are commonly assayed by dye-filling with FITC, DiI or DiO. C_elegans_phenotype_ontology WBPhenotype:0002212 amphid neuron dye filling defect Animals exhibit defects in dye-filling of the neuronal cells of the amphid sensilla. In C. elegans, these neurons are commonly assayed by dye-filling with FITC, DiI or DiO. WB:WBPerson557 Any variation that results in a decrease in the catalytic phosphorylation activity of a kinase enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). Kinases are enzymes capable of phosphorylating their respective substrates. C_elegans_phenotype_ontology WBPhenotype:0002213 kinase activity reduced Any variation that results in a decrease in the catalytic phosphorylation activity of a kinase enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). Kinases are enzymes capable of phosphorylating their respective substrates. WB:WBPaper00003656 WB:WBPerson2987 Animals contain an excess number of pharyngeal muscle cells compared to control. In C. elegans, pharyngeal cells are derived from MS-blastomere. The overproduction of pharyngeal tissues is a result of other blastomeres adopting an MS-like fate. C_elegans_phenotype_ontology WBPhenotype:0002214 extra pharyngeal muscle cells Animals contain an excess number of pharyngeal muscle cells compared to control. In C. elegans, pharyngeal cells are derived from MS-blastomere. The overproduction of pharyngeal tissues is a result of other blastomeres adopting an MS-like fate. WB:WBPaper00003574 WB:WBPerson2987 Any variation that results in a fewer than control number of body wall muscle cells. C_elegans_phenotype_ontology WBPhenotype:0002215 fewer body wall muscles Any variation that results in a fewer than control number of body wall muscle cells. WB:WBPaper00003574 WB:WBPerson2987 Any variation in the cellular or subcellular distribution of a gene product, as detected by antibody staining, compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002216 pattern antibody staining variant Any variation in the cellular or subcellular distribution of a gene product, as detected by antibody staining, compared to that observed in control animals. WB:WBPaper00003574 WB:WBPaper00003656 WB:WBPerson2987 Animals respond to antimony at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002217 antimony hypersensitive Animals respond to antimony at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00002619 WB:WBPerson2987 Animals respond to arsenite at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002218 arsenite hypersensitive Animals respond to arsenite at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00002619 WB:WBPaper00029261 WB:WBPaper00031023 WB:WBPerson2987 Animals respond to fluoranthene at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002219 fluoranthene hypersensitive Animals respond to fluoranthene at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00031850 WB:WBPerson2987 Animals respond to antimonite at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002220 antimonite hypersensitivity Animals respond to antimonite at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00029261 WB:WBPerson2987 The pharynx contains cavities, possibly indicative of inappropriate cell death. C_elegans_phenotype_ontology WBPhenotype:0002221 pharyngeal vacuole The pharynx contains cavities, possibly indicative of inappropriate cell death. WB:WBPaper00004381 WB:WBPerson2987 The uterus contains cavities, possibly indicative of inappropriate cell death. C_elegans_phenotype_ontology WBPhenotype:0002222 uterus vacuole The uterus contains cavities, possibly indicative of inappropriate cell death. WB:WBPaper00004381 WB:WBPerson2987 Animals respond at a faster rate or to lower concentrations of manganese that that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0002223 manganese hypersensitivity Animals respond at a faster rate or to lower concentrations of manganese that that observed for control animals. WB:WBPaper00044740 WB:WBPerson712 Animals respond to mercury at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002224 mercury hypersensitive Animals respond to mercury at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00004381 WB:WBPerson2987 Animals respond to lead at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002225 lead hypersensitive Animals respond to lead at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00004381 WB:WBPerson2987 Animals respond to cobalt at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002226 cobalt hypersensitive Animals respond to cobalt at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00005255 WB:WBPaper00006388 WB:WBPerson2987 Animals exhibit variations in their response to lead compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002227 lead response variant Animals exhibit variations in their response to lead compared to that observed in control animals. WB:WBPaper00029261 WB:WBPerson2987 Animals exhibit variations in their response to aluminum compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002228 aluminum response variant Animals exhibit variations in their response to aluminum compared to that observed in control animals. WB:WBPaper00029261 WB:WBPerson2987 Animals exhibit variations in their response to chromium compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002229 chromium response variant Animals exhibit variations in their response to chromium compared to that observed in control animals. WB:WBPaper00029261 WB:WBPerson2987 Animals exhibited higher amounts of internal metal concentrations compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002230 metal accumulation increased Animals exhibited higher amounts of internal metal concentrations compared to control animals. WB:WBPaper00044740 WB:WBPerson712 Oxidative stress induced by manganese differs from that of control worms. C_elegans_phenotype_ontology WBPhenotype:0002231 manganese induced oxidative stress response Oxidative stress induced by manganese differs from that of control worms. WB:WBPaper00044740 WB:WBPerson712 The polarity reversal process by which synaptic components are removed from one side of the synapse and then reformed on the opposite cell does not occur or occurs in a different manner than in controls. In C. elegans, at the end of the L1 stage, the DD neurons undergo a complete polarity reversal such that the ventral synapses disappear and new synapses are formed on opposing dorsal body muscles. C_elegans_phenotype_ontology WBPhenotype:0002232 synaptic remodeling variant The polarity reversal process by which synaptic components are removed from one side of the synapse and then reformed on the opposite cell does not occur or occurs in a different manner than in controls. In C. elegans, at the end of the L1 stage, the DD neurons undergo a complete polarity reversal such that the ventral synapses disappear and new synapses are formed on opposing dorsal body muscles. WB:WBPaper00005543 WB:WBPerson712 The swimming behavior of animals are influenced or modulate by the osmolarity of the swimming buffer. The swimming of wild-type C. elegans animals are not affected by the osmolarity of the swimming liquid. C_elegans_phenotype_ontology WBPhenotype:0002233 osmolarity modulated swimming variant The swimming behavior of animals are influenced or modulate by the osmolarity of the swimming buffer. The swimming of wild-type C. elegans animals are not affected by the osmolarity of the swimming liquid. WB:WBPaper00041219 WB:WBPerson712 Animals contain excess acidified intracellular compartments. These compartments are positive for indicators such as Acridine Orange as well as LysoTracker Red, in a lysosome-like manner. C_elegans_phenotype_ontology WBPhenotype:0002234 increased acidified compartments Animals contain excess acidified intracellular compartments. These compartments are positive for indicators such as Acridine Orange as well as LysoTracker Red, in a lysosome-like manner. WB:WBPaper00005190 WB:WBPerson712 Animals are unable to grow on media depleted of phosphate. C_elegans_phenotype_ontology WBPhenotype:0002235 growth defective on low phosphate media Animals are unable to grow on media depleted of phosphate. WB:WBPerson712 The degradation of endocytosed and intracellular material does not occur to the same extent as it does in control animals. C_elegans_phenotype_ontology WBPhenotype:0002236 endo lysosomal degradation pathway defective The degradation of endocytosed and intracellular material does not occur to the same extent as it does in control animals. WB:WBPaper00037899 WB:WBPerson712 Animals exhibit disruptions in tubular or tubulo-vesicular structures that function in endocytic transport from early to recycling endosomes. ERC organization and biogenesis defective C_elegans_phenotype_ontology WBPhenotype:0002237 endocytic recycling compartment organization and biogenesis defective Animals exhibit disruptions in tubular or tubulo-vesicular structures that function in endocytic transport from early to recycling endosomes. WB:WBPaper00037899 WB:WBPerson712 Animals exhibit increased endogenous levels of reactive oxygen species (chemically reactive molecules containing oxygen) compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002238 increased levels of reactive oxygen species Animals exhibit increased endogenous levels of reactive oxygen species (chemically reactive molecules containing oxygen) compared to that observed in control animals. WB:WBPaper00040454 WB:WBPerson2987 Animals exhibit reduced endogenous levels of reactive oxygen species (chemically reactive molecules containing oxygen) compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002239 reduced levels of reactive oxygen species Animals exhibit reduced endogenous levels of reactive oxygen species (chemically reactive molecules containing oxygen) compared to that observed in control animals. WB:WBPaper00040454 WB:WBPerson2987 Any variation in the morphology of the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes compared to control. In C. elegans these contents might include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0002240 gut granule morphology variant Any variation in the morphology of the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes compared to control. In C. elegans these contents might include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas). WB:WBPaper00040622 WB:WBPerson2987 Animals consume less food than control animals C_elegans_phenotype_ontology WBPhenotype:0002241 feeding reduced Animals consume less food than control animals WB:WBPaper00036303 WB:WBPerson2987 Animals exhibit detrimental responses to iron deficiency more readily than control animals. C_elegans_phenotype_ontology WBPhenotype:0002242 hypersensitive to iron deficiency Animals exhibit detrimental responses to iron deficiency more readily than control animals. WB:WBPaper00040550 WB:WBPerson2987 Animals do not produce the same amount of functional phytochelatins as measured in control worms. Phytochelatins are any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. C_elegans_phenotype_ontology WBPhenotype:0002243 phytochelatin synthesis deficient Animals do not produce the same amount of functional phytochelatins as measured in control worms. Phytochelatins are any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. GO:0046938 WB:WBPaper00036020 WB:WBPerson712 Animals respond to arsenic at a lower concentration or at a shorter exposure time compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002244 arsenic hypersensitive Animals respond to arsenic at a lower concentration or at a shorter exposure time compared to control animals. WB:WBPaper00036020 WB:WBPerson712 Animals exhibit reduced levels of endogenous zinc compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002245 endogenous zinc levels reduced Animals exhibit reduced levels of endogenous zinc compared to control animals. WB:WBPaper00040622 WB:WBPerson2987 Animals exhibit increased levels of endogenous zinc compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002246 endogenous zinc levels increased Animals exhibit increased levels of endogenous zinc compared to control animals. WB:WBPaper00040622 WB:WBPerson2987 Variations in the regulation of levels, transport, and metabolism of copper ions within an organism compared to control. C_elegans_phenotype_ontology WBPhenotype:0002247 copper homeostasis variant Variations in the regulation of levels, transport, and metabolism of copper ions within an organism compared to control. WB:WBPaper00040622 WB:WBPerson2987 Animals exhibit detrimental responses to zinc deficiency more readily than control animals C_elegans_phenotype_ontology WBPhenotype:0002248 hypersensitive to zinc deficiency Animals exhibit detrimental responses to zinc deficiency more readily than control animals WB:WBPaper00040622 WB:WBPerson2987 Protein oxidation levels, as measured by carbonylated protein levels for example, are reduced compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002249 reduced protein oxidation levels Protein oxidation levels, as measured by carbonylated protein levels for example, are reduced compared to controls. WB:WBPaper00040914 WB:WBPerson2987 Animals respond to silver at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002250 silver hypersensitive Animals respond to silver at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals respond to silver nanoparticles (AgNPs) at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002251 silver nanoparticle hypersensitive Animals respond to silver nanoparticles (AgNPs) at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00044630 WB:WBPerson2987 Animals are more prone to infection by virus compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002252 increased susceptibility to viral infection Animals are more prone to infection by virus compared to control animals. WB:WBPaper00046393 WB:WBPerson712 Animals exhibit lowered levels of any or all of the clades of 22G RNA molecules, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002253 22G RNA expression reduced Animals exhibit lowered levels of any or all of the clades of 22G RNA molecules, compared to control. WB:WBPaper00046393 WB:WBPerson712 Three-prime (3') uridylation of mRNA targeted for silencing does not occur at the same rate or extent of targeted mRNA in control animals. C_elegans_phenotype_ontology WBPhenotype:0002254 three prime target RNA uridylation reduced Three-prime (3') uridylation of mRNA targeted for silencing does not occur at the same rate or extent of targeted mRNA in control animals. WB:WBPaper00046393 WB:WBPerson712 Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of amino acids within the organism or cell compared to control. C_elegans_phenotype_ontology WBPhenotype:0002255 amino acid metabolism variant Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of amino acids within the organism or cell compared to control. WB:WBPaper00038278 WB:WBPerson2987 Animals exhibit variations in their response to selenium compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002256 selenium response variant Animals exhibit variations in their response to selenium compared to that observed in control animals. WB:WBPaper00038278 WB:WBPerson2987 Animals respond to iron at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002257 iron hypersensitive Animals respond to iron at a lower concentration or a shorter exposure compared to control animals. WB:WBPaper00038278 WB:WBPerson2987 Animals fail to exhibit toxicity to the concentration of nickel that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans toxic responses to nickel include delayed development or lethality. C_elegans_phenotype_ontology WBPhenotype:0002258 nickel toxicity resistant Animals fail to exhibit toxicity to the concentration of nickel that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans toxic responses to nickel include delayed development or lethality. WB:WBPaper00038278 WB:WBPerson2987 The number of terminal regions of a neuron's dendrite is less that that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0002259 dendritic termini number reduced The number of terminal regions of a neuron's dendrite is less that that observed for control animals. WB:WBPaper00046432 WB:WBPerson557 WB:WBPerson712 Ooctyes and or sperm appear vacuolated and degenerated compared to gametes in control animals. This degeneration is not due to normal programmed cell death. C_elegans_phenotype_ontology necrotic gamete degeneration increased WBPhenotype:0002260 gamete necrotic death increased Ooctyes and or sperm appear vacuolated and degenerated compared to gametes in control animals. This degeneration is not due to normal programmed cell death. WB:WBPaper00041364 WB:WBPerson712 An effective connection between reciprocal target neurons is not established properly. C_elegans_phenotype_ontology WBPhenotype:0002261 neurite connectivity defective An effective connection between reciprocal target neurons is not established properly. WB:WBPaper00042557 WB:WBPerson712 Animals display variations in the distribution of the constituents of the postsynaptic side of the active zone, compared to control animals, that are required for receiving signals from the presynaptic side. C_elegans_phenotype_ontology WBPhenotype:0002262 postsynaptic component localization variant Animals display variations in the distribution of the constituents of the postsynaptic side of the active zone, compared to control animals, that are required for receiving signals from the presynaptic side. WB:WBPaper00005543 WB:WBPaper00038066 WB:WBPerson712 Any increase in the membrane potential (voltage gradient) across the inner mitochondrial membrane compared to control. C_elegans_phenotype_ontology WBPhenotype:0002263 mitochondrial membrane potential increased Any increase in the membrane potential (voltage gradient) across the inner mitochondrial membrane compared to control. WB:WBPaper00040353 WB:WBPerson557 Animals exhibit an increase in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology. C_elegans_phenotype_ontology WBPhenotype:0002264 ATP levels increased Animals exhibit an increase in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology. WB:WBPaper00036073 WB:WBPaper00040353 WB:WBPerson557 Variations in the processes that are carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002265 lysosome-related organelle biogenesis variant Variations in the processes that are carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control. WB:WBPaper00041842 WB:WBPerson2987 Animals exhibit variations in the overall amount of mitochondria present in the animal, as determined by, for example, Mitotracker staining. C_elegans_phenotype_ontology WBPhenotype:0002266 mitochondrial content variant Animals exhibit variations in the overall amount of mitochondria present in the animal, as determined by, for example, Mitotracker staining. WB:WBPaper00035277 WB:WBPerson2987 Animals exhibit increases in the overall amount of mitochondria present in the animal, as determined by, for example, Mitotracker staining. C_elegans_phenotype_ontology WBPhenotype:0002267 mitochondrial content increased Animals exhibit increases in the overall amount of mitochondria present in the animal, as determined by, for example, Mitotracker staining. WB:WBPaper00035277 WB:WBPerson2987 Animals exhibit decreases in the overall amount of mitochondria present in the animal, as determined by, for example, Mitotracker staining. C_elegans_phenotype_ontology WBPhenotype:0002268 mitochondrial content decreased Animals exhibit decreases in the overall amount of mitochondria present in the animal, as determined by, for example, Mitotracker staining. WB:WBPaper00035277 WB:WBPerson2987 Animals exhibit an increased rate of oxygen utilization compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002269 oxygen consumption increased Animals exhibit an increased rate of oxygen utilization compared to control animals. WB:WBPaper00035277 WB:WBPerson2987 Animals exhibit a decrease in the quantity of metabolites, small molecule products or intermediates required for the metabolic functioning of the cell or organism C_elegans_phenotype_ontology WBPhenotype:0002270 metabolite content decreased Animals exhibit a decrease in the quantity of metabolites, small molecule products or intermediates required for the metabolic functioning of the cell or organism WB:WBPaper00040386 WB:WBPerson2987 Animals exhibit variations in the rate at which food is absorbed by the intestine, as determined by a time-course recording of fat staining (by C1-BODIPY-C12, for example) normalized to controls C_elegans_phenotype_ontology WBPhenotype:0002271 food absorption rate variant Animals exhibit variations in the rate at which food is absorbed by the intestine, as determined by a time-course recording of fat staining (by C1-BODIPY-C12, for example) normalized to controls WB:WBPaper00032310 WB:WBPerson2987 Animals exhibit variations in the covalent modification of one or more native amino acid side chains in proteins to carbonyl derivatives such as an aldehyde or ketone. C_elegans_phenotype_ontology WBPhenotype:0002272 protein carbonylation variant Animals exhibit variations in the covalent modification of one or more native amino acid side chains in proteins to carbonyl derivatives such as an aldehyde or ketone. WB:WBPaper00006515 Animals exhibit enhanced negative effects on growth, health, development or metabolism, in response to dietary sugar-rich diets, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002273 dietary sugar response variant Animals exhibit enhanced negative effects on growth, health, development or metabolism, in response to dietary sugar-rich diets, compared to controls. WB:WBPaper00045849 WB:WBPerson712 Males receive copulatory plugs from other males, deposited elsewhere on their bodies, in the absence of any orifice. This typically involves penetration of the depositing male's spicules directly through the cuticle of the recipient male. Plob C_elegans_phenotype_ontology WBPhenotype:0002274 plugged on body Males receive copulatory plugs from other males, deposited elsewhere on their bodies, in the absence of any orifice. This typically involves penetration of the depositing male's spicules directly through the cuticle of the recipient male. WB:WBPerson22615 WB:WBPerson7165 Males receive copulatory plugs from other males, deposited on their excretory pores. This phenotype is polymorphic among C. elegans strains and also in C. briggsae. Pleb C_elegans_phenotype_ontology Plep WBPhenotype:0002275 plugged excretory pore Males receive copulatory plugs from other males, deposited on their excretory pores. This phenotype is polymorphic among C. elegans strains and also in C. briggsae. WB:WBPerson22615 WB:WBPerson7165 The life span of dauer-staged animals is shorter than that observed in control dauer animals. C_elegans_phenotype_ontology WBPhenotype:0002276 dauer lifespan shortened The life span of dauer-staged animals is shorter than that observed in control dauer animals. WB:WBPaper00032396 WB:WBPerson2987 The life span of dauer-staged animals is longer than that observed in control dauer animals. C_elegans_phenotype_ontology WBPhenotype:0002277 dauer lifespan extended The life span of dauer-staged animals is longer than that observed in control dauer animals. WB:WBPaper00032396 WB:WBPerson2987 Animals do not develop acute functional tolerance to alcohol after a short exposure, unlike that observed in control animals C_elegans_phenotype_ontology ATF WBPhenotype:0002278 acute functional tolerance to alcohol defective Animals do not develop acute functional tolerance to alcohol after a short exposure, unlike that observed in control animals WB:WBPaper00046494 WB:WBPerson712 Animals exhibit a decrease in the size of fat containing organelles compared to control. In C. elegans this can be assayed by BODIPY 493/503 staining. C_elegans_phenotype_ontology lipid body size decreased WBPhenotype:0002279 fat associated body size decreased Animals exhibit a decrease in the size of fat containing organelles compared to control. In C. elegans this can be assayed by BODIPY 493/503 staining. WB:WBPaper00042257 WB:WBPerson2987 Animals exhibit resistance to osmotic stress compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002280 organism osmotic stress resistant Animals exhibit resistance to osmotic stress compared to that observed in control animals. WB:WBPaper00032396 WB:WBPerson2987 Animals exhibit hypersensitivty to osmotic stress compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002281 organism osmotic stress hypersensitive Animals exhibit hypersensitivty to osmotic stress compared to that observed in control animals. WB:WBPaper00032396 WB:WBPerson2987 Animals exhibit increased levels of the process by which their cells digest parts of their own cytoplasm, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002282 autophagy increased Animals exhibit increased levels of the process by which their cells digest parts of their own cytoplasm, compared to control. WB:WBPaper00026641 WB:WBPaper00038332 WB:WBPaper00041372 WB:WBPaper00043981 WB:WBPerson2987 WB:WBPerson557 Animals exhibit reduced levels of the process by which their cells digest parts of their own cytoplasm, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002283 autophagy reduced Animals exhibit reduced levels of the process by which their cells digest parts of their own cytoplasm, compared to control. WB:WBPaper00006070 WB:WBPaper00035076 WB:WBPaper00041851 WB:WBPaper00043981 WB:WBPerson2987 WB:WBPerson557 Any variation in the extent of the maximum flex of the most anterior portion of the animal compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002284 head bend angle variant Any variation in the extent of the maximum flex of the most anterior portion of the animal compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit a decrease in the extent of the maximum flex of the most anterior portion of the animal compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002285 head bend angle decreased Animals exhibit a decrease in the extent of the maximum flex of the most anterior portion of the animal compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in the extent of the maximum flex of the most anterior portion of the animal compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002286 head bend angle increased Animals exhibit an increase in the extent of the maximum flex of the most anterior portion of the animal compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 The most posterior portion of the animal exhibits variations in its movement compared to control. C_elegans_phenotype_ontology WBPhenotype:0002287 tail movement variant The most posterior portion of the animal exhibits variations in its movement compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Any variation in the extent of the maximum flex of the most posterior portion of the animal compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002288 tail bend angle variant Any variation in the extent of the maximum flex of the most posterior portion of the animal compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in the extent of the maximum flex of the most posterior portion of the animal compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002289 tail bend angle increased Animals exhibit an increase in the extent of the maximum flex of the most posterior portion of the animal compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit a decrease in the extent of the maximum flex of the most posterior portion of the animal compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002290 tail bend angle decreased Animals exhibit a decrease in the extent of the maximum flex of the most posterior portion of the animal compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in body posture with regard to the extent of displacement measured from the mean position to an extreme position compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002291 body posture amplitude variant Animals exhibit variations in body posture with regard to the extent of displacement measured from the mean position to an extreme position compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in body posture caused by a decrease in the extent of displacement measured from the mean position to an extreme position compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002292 body posture amplitude decreased Animals exhibit variations in body posture caused by a decrease in the extent of displacement measured from the mean position to an extreme position compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in body posture caused by an increase in the extent of displacement measured from the mean position to an extreme position compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002293 body posture amplitude increased Animals exhibit variations in body posture caused by an increase in the extent of displacement measured from the mean position to an extreme position compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in body posture with regard to the distance between repeating units of a wave pattern compared to control animals. In C. elegans, characteristic sinusoidal body posture is sinusoidal. C_elegans_phenotype_ontology WBPhenotype:0002294 body posture wavelength variant Animals exhibit variations in body posture with regard to the distance between repeating units of a wave pattern compared to control animals. In C. elegans, characteristic sinusoidal body posture is sinusoidal. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in body posture caused by a decrease in the distance between repeating units of a wave pattern compared to control animals. In C. elegans, characteristic sinusoidal body posture is sinusoidal. C_elegans_phenotype_ontology WBPhenotype:0002295 body posture wavelength decreased Animals exhibit variations in body posture caused by a decrease in the distance between repeating units of a wave pattern compared to control animals. In C. elegans, characteristic sinusoidal body posture is sinusoidal. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in body posture caused by an increase in the distance between repeating units of a wave pattern compared to control animals. In C. elegans, characteristic sinusoidal body posture is sinusoidal. C_elegans_phenotype_ontology WBPhenotype:0002296 body posture wavelength increased Animals exhibit variations in body posture caused by an increase in the distance between repeating units of a wave pattern compared to control animals. In C. elegans, characteristic sinusoidal body posture is sinusoidal. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in the occurrence of a coil-like body posture compared to control animals. This includes the amount of time spent in a coil, the frequency with which coils form and the inappropriate formation of a coil, for example when attempting to locomote. C_elegans_phenotype_ontology WBPhenotype:0002297 coiling variant Animals exhibit variations in the occurrence of a coil-like body posture compared to control animals. This includes the amount of time spent in a coil, the frequency with which coils form and the inappropriate formation of a coil, for example when attempting to locomote. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in the amount of time spent with its body posture in a coil or the frequency with which they form coils compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002298 coiling frequency variant Animals exhibit variations in the amount of time spent with its body posture in a coil or the frequency with which they form coils compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals spend less time with their body posture in a coil or they decrease the frequency with which they form coils compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002299 coiling frequency decreased Animals spend less time with their body posture in a coil or they decrease the frequency with which they form coils compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals spend more time with their body posture in a coil or they increase the frequency with which they form coils compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002300 coiling frequency increased Animals spend more time with their body posture in a coil or they increase the frequency with which they form coils compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 The extreme anterior of the animal exhibits variations in its movement compared to control. C_elegans_phenotype_ontology WBPhenotype:0002301 nose movement variant The extreme anterior of the animal exhibits variations in its movement compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit a decrease in the movement of the extreme anterior portion of the body to a new location compared to control. C_elegans_phenotype_ontology WBPhenotype:0002302 nose movement decreased Animals exhibit a decrease in the movement of the extreme anterior portion of the body to a new location compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in the movement of the extreme anterior portion of the body to a new location compared to control. C_elegans_phenotype_ontology WBPhenotype:0002303 nose movement increased Animals exhibit an increase in the movement of the extreme anterior portion of the body to a new location compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit a decrease in the movement of the most anterior portion of the body to a new location compared to control. C_elegans_phenotype_ontology WBPhenotype:0002304 head movement decreased Animals exhibit a decrease in the movement of the most anterior portion of the body to a new location compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in the movement of the most anterior portion of the body to a new location compared to control. C_elegans_phenotype_ontology WBPhenotype:0002305 head movement increased Animals exhibit an increase in the movement of the most anterior portion of the body to a new location compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit a decrease in the movement of the most posterior portion of the body to a new location compared to control. C_elegans_phenotype_ontology WBPhenotype:0002306 tail movement decreased Animals exhibit a decrease in the movement of the most posterior portion of the body to a new location compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in the movement of the most posterior portion of the body to a new location compared to control. C_elegans_phenotype_ontology WBPhenotype:0002307 tail movement increased Animals exhibit an increase in the movement of the most posterior portion of the body to a new location compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in the amount of time spent in a paused state, which is neither moving forward or backward, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002308 pausing variant Animals exhibit variations in the amount of time spent in a paused state, which is neither moving forward or backward, compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit a decrease in the amount of time spent in a paused state, which is neither moving forward or backward, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002309 pausing decreased Animals exhibit a decrease in the amount of time spent in a paused state, which is neither moving forward or backward, compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in the amount of time spent in a paused state, which is neither moving forward or backward, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002310 pausing increased Animals exhibit an increase in the amount of time spent in a paused state, which is neither moving forward or backward, compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Variations in the behavior by which an organism alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal). C_elegans_phenotype_ontology WBPhenotype:0002311 turning variant Variations in the behavior by which an organism alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal). WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in the frequency of execution of the behavior by which the animal alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal). C_elegans_phenotype_ontology WBPhenotype:0002312 turning frequency variant Animals exhibit variations in the frequency of execution of the behavior by which the animal alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal). WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in the frequency of execution of the behavior by which the animal alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal). C_elegans_phenotype_ontology WBPhenotype:0002313 turning frequency increased Animals exhibit an increase in the frequency of execution of the behavior by which the animal alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal). WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit a decrease in the frequency of execution of the behavior by which the animal alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal). C_elegans_phenotype_ontology WBPhenotype:0002314 turning frequency reduced Animals exhibit a decrease in the frequency of execution of the behavior by which the animal alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal). WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in their movement at high-speed in the forward direction with brief backward movement compared to control. During roaming, control animals often traverse wide regions. C_elegans_phenotype_ontology path range variant WBPhenotype:0002315 roaming variant Animals exhibit variations in their movement at high-speed in the forward direction with brief backward movement compared to control. During roaming, control animals often traverse wide regions. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in the low-speed/high turning movement that restricts them to a confined region compared to control. C_elegans_phenotype_ontology WBPhenotype:0002316 dwelling variant Animals exhibit variations in the low-speed/high turning movement that restricts them to a confined region compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in the low-speed/high turning movement that usually restricts them to a confined region compared to control. C_elegans_phenotype_ontology WBPhenotype:0002317 dwelling increased Animals exhibit an increase in the low-speed/high turning movement that usually restricts them to a confined region compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit a decrease in the low-speed/high turning movement that usually restricts them to a confined region compared to control. C_elegans_phenotype_ontology WBPhenotype:0002318 dwelling reduced Animals exhibit a decrease in the low-speed/high turning movement that usually restricts them to a confined region compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in their high-speed movement in the forward direction with brief backward movement compared to control. C_elegans_phenotype_ontology path range increased WBPhenotype:0002319 roaming increased Animals exhibit an increase in their high-speed movement in the forward direction with brief backward movement compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Variations in the behavior by which an organism shifts from forward to backward movements. C_elegans_phenotype_ontology WBPhenotype:0002320 reversal variant Variations in the behavior by which an organism shifts from forward to backward movements. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit decreased velocity of forward translocation of any point along the animal's track from that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0002321 forward point velocity decreased Animals exhibit decreased velocity of forward translocation of any point along the animal's track from that observed for control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit increased velocity of forward translocation of any point along the animal's track from that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0002322 forward point velocity increased Animals exhibit increased velocity of forward translocation of any point along the animal's track from that observed for control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in the velocity of backward translocation of any point along the animal's track from that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0002323 backward point velocity variant Animals exhibit variations in the velocity of backward translocation of any point along the animal's track from that observed for control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit decreased velocity of backward translocation of any point along the animal's track from that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0002324 backward point velocity decreased Animals exhibit decreased velocity of backward translocation of any point along the animal's track from that observed for control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit increased velocity of backward translocation of any point along the animal's track from that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0002325 backward point velocity increased Animals exhibit increased velocity of backward translocation of any point along the animal's track from that observed for control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit a decrease in the net velocity of an animal. C_elegans_phenotype_ontology sluggish WBPhenotype:0002326 velocity of movement decreased Animals exhibit a decrease in the net velocity of an animal. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in the net velocity of an animal C_elegans_phenotype_ontology WBPhenotype:0002327 velocity of movement increased Animals exhibit an increase in the net velocity of an animal WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control. amplitude of body bends increased C_elegans_phenotype_ontology WBPhenotype:0002328 amplitude of sinusoidal movement increased Animals exhibit an increase in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0002329 obsolete temporal frequency of sinusoidal movement variant true OBSOLETE. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0002330 obsolete temporal frequency of sinusoidal movement decreased true OBSOLETE. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0002331 obsolete temporal frequency of sinusoidal movement increased true OBSOLETE. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in the length of the minimum enclosing rectangle surrounding the worm body on a solid medium, as viewed through the microscope. C_elegans_phenotype_ontology WBPhenotype:0002332 track length variant Animals exhibit variations in the length of the minimum enclosing rectangle surrounding the worm body on a solid medium, as viewed through the microscope. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit increased length of the minimum enclosing rectangle surrounding the worm body on a solid medium, as viewed through the microscope. C_elegans_phenotype_ontology WBPhenotype:0002333 track length increased Animals exhibit increased length of the minimum enclosing rectangle surrounding the worm body on a solid medium, as viewed through the microscope. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit decreased length of the minimum enclosing rectangle surrounding the worm body on a solid medium, as viewed through the microscope. C_elegans_phenotype_ontology WBPhenotype:0002334 track length decreased Animals exhibit decreased length of the minimum enclosing rectangle surrounding the worm body on a solid medium, as viewed through the microscope. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in the extent to which the overall path of movement is curved, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002335 path curvature variant Animals exhibit variations in the extent to which the overall path of movement is curved, compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit increases in the extent to which the overall path of movement is curved, producing tighter and more frequent curves compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002336 path curvature increased Animals exhibit increases in the extent to which the overall path of movement is curved, producing tighter and more frequent curves compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit decreases in the extent to which the overall path of movement is curved, producing shallower, less frequent curves and an overall straighter path, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002337 path curvature decreased Animals exhibit decreases in the extent to which the overall path of movement is curved, producing shallower, less frequent curves and an overall straighter path, compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in the body-area-to-length ratio and/or the width-to-length ratio, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002338 body proportion variant Animals exhibit variations in the body-area-to-length ratio and/or the width-to-length ratio, compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit increases in the body-area-to-length ratio and/or the width-to-length ratio, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002339 body proportion increased Animals exhibit increases in the body-area-to-length ratio and/or the width-to-length ratio, compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit decreases in the body-area-to-length ratio and/or the width-to-length ratio, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002340 body proportion decreased Animals exhibit decreases in the body-area-to-length ratio and/or the width-to-length ratio, compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit variations in instantaneous posture with regards to eccentricity (measure of circularity) or the mean number (and/or standard deviation) of instantaneous body bends. C_elegans_phenotype_ontology WBPhenotype:0002341 bent posture variant Animals exhibit variations in instantaneous posture with regards to eccentricity (measure of circularity) or the mean number (and/or standard deviation) of instantaneous body bends. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit increased posture eccentricity (measure of circularity) or the mean number (and/or standard deviation) of instantaneous body bends. C_elegans_phenotype_ontology WBPhenotype:0002342 bent posture increased Animals exhibit increased posture eccentricity (measure of circularity) or the mean number (and/or standard deviation) of instantaneous body bends. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit decreased posture eccentricity (measure of circularity) or the mean number (and/or standard deviation) of instantaneous body bends. C_elegans_phenotype_ontology WBPhenotype:0002343 bent posture decreased Animals exhibit decreased posture eccentricity (measure of circularity) or the mean number (and/or standard deviation) of instantaneous body bends. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals spend less time backing compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002344 backing decreased Animals spend less time backing compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Variations in the spontaneous or induced forward crawling locomotion of an animal compared to control. C_elegans_phenotype_ontology WBPhenotype:0002345 forward locomotion variant Variations in the spontaneous or induced forward crawling locomotion of an animal compared to control. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals spend more time in forward locomotion, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002346 forward locomotion increased Animals spend more time in forward locomotion, compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals spend less time in forward locomotion, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002347 forward locomotion decreased Animals spend less time in forward locomotion, compared to control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in the frequency of oscillations between adjacent body segments from that observed for control animals. WBPhenotype:0002331 frequency of sinusoidal movement increased temporal frequency of sinusoidal movement increased C_elegans_phenotype_ontology WBPhenotype:0002348 frequency of body bends increased Animals exhibit an increase in the frequency of oscillations between adjacent body segments from that observed for control animals. WB:WBPaper00043908 WB:WBPerson2987 WB:WBPerson557 The levels of phosphatidylinositol 3-phosphate (a.k.a. PtdIns3P or PI3P) are reduced compared to those of control animals C_elegans_phenotype_ontology WBPhenotype:0002349 phosphatidylinositol 3-phosphate levels reduced The levels of phosphatidylinositol 3-phosphate (a.k.a. PtdIns3P or PI3P) are reduced compared to those of control animals WB:WBPaper00044390 WB:WBPerson2987 Animals exhibit increases in steady-state levels of hydrogen peroxide (H2O2) compared to control. C_elegans_phenotype_ontology WBPhenotype:0002350 hydrogen peroxide levels increased Animals exhibit increases in steady-state levels of hydrogen peroxide (H2O2) compared to control. WB:WBPaper00041478 WB:WBPerson2987 Animals exhibit reductions in steady-state levels of hydrogen peroxide (H2O2) compared to control. C_elegans_phenotype_ontology WBPhenotype:0002351 hydrogen peroxide levels reduced Animals exhibit reductions in steady-state levels of hydrogen peroxide (H2O2) compared to control. WB:WBPaper00041478 WB:WBPerson2987 Animals exhibit elevated levels of transfer RNA compared to control. C_elegans_phenotype_ontology WBPhenotype:0002352 tRNA expression increased Animals exhibit elevated levels of transfer RNA compared to control. WB:WBPaper00046188 WB:WBPerson2987 Animals exhibit reduced levels of transfer RNA compared to control. C_elegans_phenotype_ontology WBPhenotype:0002353 tRNA expression decreased Animals exhibit reduced levels of transfer RNA compared to control. WB:WBPaper00046188 WB:WBPerson2987 Animals are more prone to infection from fungal pathogens compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002354 increased susceptibility to fungal infection Animals are more prone to infection from fungal pathogens compared to control animals. WB:WBPaper00045575 WB:WBPerson712 Animals are more prone to infection by bacterial pathogens compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002355 increased susceptibility to bacterial pathogens Animals are more prone to infection by bacterial pathogens compared to control animals. WB:WBPaper00045575 WB:WBPerson712 Animals are negatively affected by bacteria that is nonpathogenic to control animals. C_elegans_phenotype_ontology WBPhenotype:0002356 sickened by nonpathogenic bacteria Animals are negatively affected by bacteria that is nonpathogenic to control animals. WB:WBPaper00045575 WB:WBPerson712 Animals exhibit an increase in the quantity of metabolites, small molecule products or intermediates required for the metabolic functioning of the cell or organism. C_elegans_phenotype_ontology WBPhenotype:0002357 metabolite content increased Animals exhibit an increase in the quantity of metabolites, small molecule products or intermediates required for the metabolic functioning of the cell or organism. WB:WBPaper00045546 WB:WBPaper00045575 WB:WBPerson712 The conversion of one differentiated cell type into another does not occur as it does in control animals. In C. elegans, the Y cell undergoes a dramatic redifferentiation from being a cell in of the rectum to a PDA neuron. This transdifferentiation requires the cell to withdraw from its established position, migrate, and then become a motor neuron. C_elegans_phenotype_ontology WBPhenotype:0002358 transdifferentiation defective The conversion of one differentiated cell type into another does not occur as it does in control animals. In C. elegans, the Y cell undergoes a dramatic redifferentiation from being a cell in of the rectum to a PDA neuron. This transdifferentiation requires the cell to withdraw from its established position, migrate, and then become a motor neuron. WB:WBPaper00037659 WB:WBPerson712 Animals exhibit an increase in the covalent modification of one or more native amino acid side chains in proteins to carbonyl derivatives such as an aldehyde or ketone. C_elegans_phenotype_ontology WBPhenotype:0002359 protein carbonylation increased Animals exhibit an increase in the covalent modification of one or more native amino acid side chains in proteins to carbonyl derivatives such as an aldehyde or ketone. WB:WBPaper00041478 WB:WBPerson2987 Animals respond more severely to cold than control animals subjected to the same cold conditions. C_elegans_phenotype_ontology WBPhenotype:0002360 cold hypersensitive Animals respond more severely to cold than control animals subjected to the same cold conditions. WB:WBPaper00046830 WB:WBPerson2987 Animals exhibit increased fluidity of cell membranes, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002361 membrane fluidity increased Animals exhibit increased fluidity of cell membranes, compared to control animals. WB:WBPaper00046830 WB:WBPerson2987 Variations in the process by which one or more SUMO moieties are added to a protein, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002362 protein sumoylation variant Variations in the process by which one or more SUMO moieties are added to a protein, compared to control. WB:WBPaper00048594 WB:WBPerson2987 WB:WBPerson557 Animals are more resistant to the reduction of cholesterol in the environment compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002363 cholesterol depletion resistant Animals are more resistant to the reduction of cholesterol in the environment compared to control animals. WB:WBPaper00024451 WB:WBPerson2987 WB:WBPerson557 Spontaneous axon breaks leading to degeneration of separated segments. axon degeneration C_elegans_phenotype_ontology WBPhenotype:0002364 axonal degeneration Spontaneous axon breaks leading to degeneration of separated segments. WB:WBPaper00024451 WB:WBPerson2987 WB:WBPerson9270 Following axon damage, animals do not undergo axonal fusion after reconnection between the regrowing axon and its separated segment to the same extent as observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002365 regenerative axonal fusion defective Following axon damage, animals do not undergo axonal fusion after reconnection between the regrowing axon and its separated segment to the same extent as observed in control animals. WB:WBPaper00046306 WB:WBPerson29819 WB:WBPerson2987 Animals do not suppress exploratory head movements in response to anterior touch stimuli, unlike control animals. C_elegans_phenotype_ontology WBPhenotype:0002366 touch-induced suppression of head movement defective Animals do not suppress exploratory head movements in response to anterior touch stimuli, unlike control animals. WB:WBPaper00039982 WB:WBPerson712 Animals are less successful than controls in extracting themselves from mesh or other non-living obstructing obstacles. C_elegans_phenotype_ontology WBPhenotype:0002367 non-living barrier escape defective Animals are less successful than controls in extracting themselves from mesh or other non-living obstructing obstacles. WB:WBPaper00039982 WB:WBPerson712 Lysosomal refractile bodies are apoptotic-like cell corpse; however, they differ in size and shape and can be described as resembling irregular cell corpses. These bodies have been shown to represent enlarged lysosomes and can occur in conjunction with altered programmed cell death programs. C_elegans_phenotype_ontology WBPhenotype:0002368 lysosomal refractile body accumulation Lysosomal refractile bodies are apoptotic-like cell corpse; however, they differ in size and shape and can be described as resembling irregular cell corpses. These bodies have been shown to represent enlarged lysosomes and can occur in conjunction with altered programmed cell death programs. WB:WBPaper00005190 WB:WBPerson712 Animals exhibit sister cells that have lost otherwise normal asynchrony of cell division timing, compared to control animals. This results in sister cells aberrantly dividing in synchrony. C_elegans_phenotype_ontology WBPhenotype:0002369 sister cell division timing asynchrony reduced Animals exhibit sister cells that have lost otherwise normal asynchrony of cell division timing, compared to control animals. This results in sister cells aberrantly dividing in synchrony. WB:WBPaper00046953 WB:WBPerson2987 Animals fail to execute their characteristic movements to avoid noxious heat in a manner consistent with controls. C_elegans_phenotype_ontology WBPhenotype:0002370 noxious heat avoidance defective Animals fail to execute their characteristic movements to avoid noxious heat in a manner consistent with controls. WB:WBPaper00046106 WB:WBPerson12691 WB:WBPerson557 Vesicles, including those in cells, cell bodies, or synaptic terminals, do not properly form or maintain an intermediate state, such as remain coated with a clathrin coat. C_elegans_phenotype_ontology WBPhenotype:0002371 vesicle maturation defective Vesicles, including those in cells, cell bodies, or synaptic terminals, do not properly form or maintain an intermediate state, such as remain coated with a clathrin coat. WB:WBPaper00004275 WB:WBPerson712 Vesicles in the presynaptic terminal differ in size, shape, or composition from those observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002372 presynaptic vesicle morphology altered Vesicles in the presynaptic terminal differ in size, shape, or composition from those observed in control animals. WB:WBPaper00004275 WB:WBPerson712 Animals show a stronger preference for a particular bacterium that has been grown under conditions that differ from a control lawn. C_elegans_phenotype_ontology WBPhenotype:0002373 conditional attraction to bacterial lawn Animals show a stronger preference for a particular bacterium that has been grown under conditions that differ from a control lawn. WB:WBPaper00048410 WB:WBPerson712 Animals are deficient in the transport of silencing RNAs between cells during the systemic RNAi response process. C_elegans_phenotype_ontology WBPhenotype:0002374 RNAi transport defective Animals are deficient in the transport of silencing RNAs between cells during the systemic RNAi response process. WB:WBPaper00041467 WB:WBPerson712 Animals that exhibit paralysis (reduced thrashing) revert back to normal swimming behavior that can be tabulated as a reversion index (number revertants/number paralysis) and reversion probability (time in reversion/time after paralysis). C_elegans_phenotype_ontology WBPhenotype:0002375 reversion of swimming paralysis Animals that exhibit paralysis (reduced thrashing) revert back to normal swimming behavior that can be tabulated as a reversion index (number revertants/number paralysis) and reversion probability (time in reversion/time after paralysis). WB:WBPaper00041219 WB:WBPerson712 Animals exhibit one or more mRNAs with decreased length of the 3' polyadenine tail, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002376 mRNA poly-A tail length decreased Animals exhibit one or more mRNAs with decreased length of the 3' polyadenine tail, compared to control. WB:WBPaper00046960 WB:WBPerson2987 Animals exhibit one or more mRNAs with increased length of the 3' polyadenine tail, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002377 mRNA poly-A tail length increased Animals exhibit one or more mRNAs with increased length of the 3' polyadenine tail, compared to control. WB:WBPaper00046960 WB:WBPerson2987 Variations in the characteristic movement away from specific disease causing agents (pathogens) compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002378 pathogen avoidance variant Variations in the characteristic movement away from specific disease causing agents (pathogens) compared to control animals. WB:WBPaper00048530 WB:WBPerson495 WB:WBPerson557 The subcellular localization of mitochondrial organelles differ from that observed in control cells. C_elegans_phenotype_ontology WBPhenotype:0002379 mitochondria localization variant The subcellular localization of mitochondrial organelles differ from that observed in control cells. WB:WBPaper00045008 WB:WBPerson298 WB:WBPerson557 Neurons undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles at a faster rate or greater extent than those under conditions that elicit this response in control animals. C_elegans_phenotype_ontology increased neurodegeneration WBPhenotype:0002380 neuron degeneration enhanced Neurons undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles at a faster rate or greater extent than those under conditions that elicit this response in control animals. WB:WBPaper00045008 WB:WBPerson298 WB:WBPerson557 Animals exhibit variations in the amount and/or quality of pheromone produced compared to control animals at a defined stage. C_elegans_phenotype_ontology WBPhenotype:0002381 pheromone production variant Animals exhibit variations in the amount and/or quality of pheromone produced compared to control animals at a defined stage. WB:WBPaper00046134 WB:WBPerson14245 WB:WBPerson557 Animals fail to respond to the concentration of a bioactive compound that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. A bioactive compound is a chemical found in small amounts in organisms or, synthetically produced, that has effects on biological processes in another organism. C_elegans_phenotype_ontology WBPhenotype:0002382 resistant to bioactive compound Animals fail to respond to the concentration of a bioactive compound that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. A bioactive compound is a chemical found in small amounts in organisms or, synthetically produced, that has effects on biological processes in another organism. WB:WBPaper00045930 WB:WBPerson12526 WB:WBPerson557 Any variation in the decreased behavioral response to repeated light head or tail touch compared to control. A gentle touch to the animal's head causes backward movement, whereas a gentle touch to the animal's tail causes forward movement. When wild-type animals are touched repeatedly on the head or tail, after some repetition they stop responding to the touch stimulus. C_elegans_phenotype_ontology WBPhenotype:0002383 light touch habituation variant Any variation in the decreased behavioral response to repeated light head or tail touch compared to control. A gentle touch to the animal's head causes backward movement, whereas a gentle touch to the animal's tail causes forward movement. When wild-type animals are touched repeatedly on the head or tail, after some repetition they stop responding to the touch stimulus. WB:WBPaper00041335 WB:WBPerson5092 WB:WBPerson557 Animals are resistant to the toxicity of an anti-infective xenobiotic such as R24. Such small molecules protect the host from bacterial infection by inducing antibacterial immune responses via the p38 MAPK pathway. These molecules tend to have toxic effects in addition to immunostimulatory activity. Xts C_elegans_phenotype_ontology Xenobiotic toxicity resistant WBPhenotype:0002384 xenotoxicity suppressor Animals are resistant to the toxicity of an anti-infective xenobiotic such as R24. Such small molecules protect the host from bacterial infection by inducing antibacterial immune responses via the p38 MAPK pathway. These molecules tend to have toxic effects in addition to immunostimulatory activity. WB:WBPerson512 Animals fail to avoid a high pH (alkaline) environment as compared to control animals. This is at very high pH, for example around pH11. C_elegans_phenotype_ontology WBPhenotype:0002385 high pH avoidance defective Animals fail to avoid a high pH (alkaline) environment as compared to control animals. This is at very high pH, for example around pH11. WB:WBPaper00043891 WB:WBPerson1928 Animals exhibit variations in the assembly of the fibrous body-membranous organelle (FB-MO), a nematode sperm-specific organelle involved in cytoplasmic partitioning during spermatogenesis, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002386 fibrous body-membranous organelle (FB-MO) assembly variant Animals exhibit variations in the assembly of the fibrous body-membranous organelle (FB-MO), a nematode sperm-specific organelle involved in cytoplasmic partitioning during spermatogenesis, compared to control animals. WB:WBPaper00041071 WB:WBPerson602 Dividing cells exhibit additional arrays of microtubules emanating from a spindle pole that do not connect to kinetochores, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002387 supernumerary asters Dividing cells exhibit additional arrays of microtubules emanating from a spindle pole that do not connect to kinetochores, compared to control. WB:WBPaper00041071 WB:WBPerson602 Any variation in the second stage of cell division, between prophase and anaphase, during which the chromosomes become attached to the spindle fibers. C_elegans_phenotype_ontology WBPhenotype:0002388 metaphase variant Any variation in the second stage of cell division, between prophase and anaphase, during which the chromosomes become attached to the spindle fibers. WB:WBPaper00000008 WB:WBPerson2987 Any variation in the stage of meiotic or mitotic cell division in which the chromosomes move away from one another to opposite poles of the spindle. C_elegans_phenotype_ontology WBPhenotype:0002389 anaphase variant Any variation in the stage of meiotic or mitotic cell division in which the chromosomes move away from one another to opposite poles of the spindle. WB:WBPaper00000008 WB:WBPerson2987 Animals exhibit larger variations in cell division timing events than in controls. C_elegans_phenotype_ontology WBPhenotype:0002390 variable cell division timing Animals exhibit larger variations in cell division timing events than in controls. WB:WBPaper00046953 WB:WBPerson2987 Cells attempt to divide but fail to form two daughter cells. C_elegans_phenotype_ontology WBPhenotype:0002391 cytokinesis failure Cells attempt to divide but fail to form two daughter cells. WB:WBPaper00041071 WB:WBPerson557 A depletion of somatic, but not germline, lipid stores are observed near the end of the reproductive period. Asdf C_elegans_phenotype_ontology WBPhenotype:0002392 age dependent somatic depletion of fat A depletion of somatic, but not germline, lipid stores are observed near the end of the reproductive period. WB:WBPaper00048925 WB:WBPerson2173 Any variation in the processes that govern the directed extension of neurite projections along the anteroposterior axis of the animal compared to controls. C_elegans_phenotype_ontology anteroposterior neurite growth variant WBPhenotype:0002393 anterior posterior neurite growth variant Any variation in the processes that govern the directed extension of neurite projections along the anteroposterior axis of the animal compared to controls. WB:WBPaper00041941 WB:WBPerson1687 WB:WBPerson557 The closure of a phagosome does not occur and it remains connected with the plasma membrane, leaving the lumen open to the outside. Complete closure usually occurs once an apoptotic cell has been surrounded by an engulfing cell. C_elegans_phenotype_ontology WBPhenotype:0002394 phagosome sealing defective The closure of a phagosome does not occur and it remains connected with the plasma membrane, leaving the lumen open to the outside. Complete closure usually occurs once an apoptotic cell has been surrounded by an engulfing cell. WB:WBPaper00048406 WB:WBPerson17560 WB:WBPerson2987 Animals exhibit variations in recognition of cell corpses and initiation of corpse engulfment, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002395 corpse engulfment initiation variant Animals exhibit variations in recognition of cell corpses and initiation of corpse engulfment, compared to controls. WB:WBPaper00048406 WB:WBPerson2987 Animals with a tumorous germline exhibit a decreased frequency of the presence of a tumor prolapse, a protrusion of tumor cells from the vulva, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002396 tumor prolapse frequency decreased Animals with a tumorous germline exhibit a decreased frequency of the presence of a tumor prolapse, a protrusion of tumor cells from the vulva, compared to control. WB:WBPaper00049105 WB:WBPerson2987 Animals with a tumorous germline exhibit an increased frequency of the presence of a tumor prolapse, a protrusion of tumor cells from the vulva, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002397 tumor prolapse frequency increased Animals with a tumorous germline exhibit an increased frequency of the presence of a tumor prolapse, a protrusion of tumor cells from the vulva, compared to control. WB:WBPaper00049105 WB:WBPerson2987 Animals exhibit variations in the aggregation behavior of starved L1 larvae, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002398 starved L1 larvae aggregation variant Animals exhibit variations in the aggregation behavior of starved L1 larvae, compared to controls. WB:WBPaper00046860 WB:WBPerson14935 Animals exhibit variations in their response to a specific neurotransmitter compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002399 neurotransmitter response variant Animals exhibit variations in their response to a specific neurotransmitter compared to that observed in control animals. WB:WBPaper00048522 WB:WBPerson2987 Animals do not live or live poorly in the presence of glucose concentrations that normally do not have an effect on control animals. C_elegans_phenotype_ontology WBPhenotype:0002400 glucose intolerant Animals do not live or live poorly in the presence of glucose concentrations that normally do not have an effect on control animals. WB:WBPaper00049467 WB:WBPerson712 The concentration of fatty acids in the animal are greater than that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0002401 excess fatty acids The concentration of fatty acids in the animal are greater than that observed for control animals. WB:WBPaper00049467 WB:WBPerson712 A cell (or group of cells) is not found in the correct body position compared the placement in control animals. cell position abnormal C_elegans_phenotype_ontology WBPhenotype:0002402 cell position defective A cell (or group of cells) is not found in the correct body position compared the placement in control animals. WB:WBPerson557 Ventral midline blastomeres (P cells) are misaligned (not properly paired) along the ventral midline of larval animals. C_elegans_phenotype_ontology WBPhenotype:0002403 P cell misalignment at ventral midline Ventral midline blastomeres (P cells) are misaligned (not properly paired) along the ventral midline of larval animals. WB:WBPaper00040551 WB:WBPerson2987 Cell-cell contacts are abnormal, compared to control animals. C_elegans_phenotype_ontology cell cell contacts abnormal WBPhenotype:0002404 cell cell contacts abnormal Cell-cell contacts are abnormal, compared to control animals. WB:WBPaper00040551 WB:WBPerson2987 Animals exhibit variations in the behavioral response to pheromones, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002405 pheromone behavioral response variant Animals exhibit variations in the behavioral response to pheromones, compared to control. WB:WBPaper00040651 WB:WBPerson2987 Any neurite that is extended towards the posterior of the animal from neurons that in wild-type animals make only anterior projections (e.g. D-type neurons in C. elegans). C_elegans_phenotype_ontology WBPhenotype:0002406 aberrant posteriorly-directed neurite Any neurite that is extended towards the posterior of the animal from neurons that in wild-type animals make only anterior projections (e.g. D-type neurons in C. elegans). WB:WBPerson1687 WB:WBPerson557 Any variation in the overall size of fertilized oocytes that are laid compared to those laid by control animals. C_elegans_phenotype_ontology egg size abnormal WBPhenotype:0002407 egg size variant Any variation in the overall size of fertilized oocytes that are laid compared to those laid by control animals. WB:WBPerson557 Any variation that disrupts the cytoplasmic division of a cell during development compared to control. C_elegans_phenotype_ontology cytokinesis abnormal WBPhenotype:0002408 cytokinesis variant Any variation that disrupts the cytoplasmic division of a cell during development compared to control. GO:0000910 WB:WBPerson557 One or more extra cleavage furrows are observed in a cell about to undergo division. C_elegans_phenotype_ontology WBPhenotype:0002409 extra cleavage furrow One or more extra cleavage furrows are observed in a cell about to undergo division. WB:WBPerson557 Cells exhibit defects in the formation, maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis. C_elegans_phenotype_ontology WBPhenotype:0002410 cleavage furrow defective Cells exhibit defects in the formation, maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis. GO:0032154 WB:WBPerson557 Cells exhibit defects in the formation of the groove in the cell surface near the old metaphase plate at the onset of cytokinesis. C_elegans_phenotype_ontology WBPhenotype:0002411 cleavage furrow initiation defective Cells exhibit defects in the formation of the groove in the cell surface near the old metaphase plate at the onset of cytokinesis. WB:WBPerson557 Cells exhibit defects in the maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis. C_elegans_phenotype_ontology WBPhenotype:0002412 cleavage furrow termination defective Cells exhibit defects in the maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis. WB:WBPerson557 Animals have more than one nucleus in a particular cell type. C_elegans_phenotype_ontology WBPhenotype:0002413 multiple nuclei Animals have more than one nucleus in a particular cell type. WB:WBPerson557 Any variation in the assembly, disassembly, arrangement, elongation or stabilization of the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart compared to control. C_elegans_phenotype_ontology spindle abnormal WBPhenotype:0002414 spindle variant Any variation in the assembly, disassembly, arrangement, elongation or stabilization of the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart compared to control. GO:0005819 WB:WBPerson557 Cells exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. C_elegans_phenotype_ontology WBPhenotype:0002415 spindle assembly defective Cells exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. GO:0051225 WB:WBPerson557 Any variation in the placement of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis compared to control. C_elegans_phenotype_ontology WBPhenotype:0002416 spindle position variant Any variation in the placement of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis compared to control. GO:0051653 WB:WBPerson557 Any variation in the rotation of the spindle compared to control. C_elegans_phenotype_ontology WBPhenotype:0002417 spindle rotation variant Any variation in the rotation of the spindle compared to control. WB:WBPerson557 Cells lack the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis. C_elegans_phenotype_ontology WBPhenotype:0002418 spindle absent Cells lack the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis. GO:0005819 WB:WBPerson557 Any variation in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle asters during a cell cycle. C_elegans_phenotype_ontology WBPhenotype:0002419 spindle aster variant Any variation in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle asters during a cell cycle. WB:WBPerson557 Animals exhibit variations in the nature and/or extent of chromatin modification, including but not limited to acetylation and/or methylation of histones, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002420 chromatin modification variant Animals exhibit variations in the nature and/or extent of chromatin modification, including but not limited to acetylation and/or methylation of histones, compared to controls. WB:WBPaper00036090 WB:WBPerson2987 Animals exhibit increased ability to survive at low temperatures compared to controls. cold tolerant C_elegans_phenotype_ontology WBPhenotype:0002421 cold resistant Animals exhibit increased ability to survive at low temperatures compared to controls. WB:WBPerson10321 WB:WBPerson557 Animals respond to tunicamycin at a higher concentration or a longer exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002422 tunicamycin resistant Animals respond to tunicamycin at a higher concentration or a longer exposure compared to control animals. WB:WBPaper00036076 WB:WBPaper00037064 WB:WBPerson2987 Animals exhibit variations in response to hypoxia, low oxygen conditions, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002423 hypoxia response variant Animals exhibit variations in response to hypoxia, low oxygen conditions, compared to controls. WB:WBPaper00037064 WB:WBPerson2987 Animals exhibit variations in response to anoxia, trace oxygen conditions, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002424 anoxia response variant Animals exhibit variations in response to anoxia, trace oxygen conditions, compared to controls. WB:WBPerson557 Variations in the specific actions or reactions in response to external or internal stimuli in response to the aggregation of proteins. C_elegans_phenotype_ontology WBPhenotype:0002425 protein aggregation induced behavior variant Variations in the specific actions or reactions in response to external or internal stimuli in response to the aggregation of proteins. WB:WBPerson324 WB:WBPerson557 The duration of viability in the adult phase of the life-cycle is lowered in response to the aggregation of proteins. C_elegans_phenotype_ontology WBPhenotype:0002426 protein aggregation induced reduction of life span The duration of viability in the adult phase of the life-cycle is lowered in response to the aggregation of proteins. GO:0008340 WB:WBPaper00035872 WB:WBPerson324 WB:WBPerson557 Variations in the behavioral plasticity induced by the integration of two sensory signals in response to the aggregation of proteins. C_elegans_phenotype_ontology WBPhenotype:0002427 protein aggregation induced associative learning variant Variations in the behavioral plasticity induced by the integration of two sensory signals in response to the aggregation of proteins. WB:WBPaper00035872 WB:WBPerson324 WB:WBPerson557 Animals exhibit degeneration of the intestine, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002428 intestinal degeneration Animals exhibit degeneration of the intestine, compared to control animals. WB:WBPaper00041065 WB:WBPerson2987 Animals exhibit variations in the degree to which some proteins are glycosylated, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002429 protein glycosylation variant Animals exhibit variations in the degree to which some proteins are glycosylated, compared to controls. WB:WBPaper00042060 WB:WBPerson2987 Any variation in the extent of mitochondrial DNA damage observed compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002430 mitochondrial DNA damage variant Any variation in the extent of mitochondrial DNA damage observed compared to controls. WB:WBPaper00041209 WB:WBPerson712 A telomerase-independent telomere maintenance pathway that allows for strains to survive in the absence of telomerase. ALT C_elegans_phenotype_ontology WBPhenotype:0002431 alternative lengthening of telomeres A telomerase-independent telomere maintenance pathway that allows for strains to survive in the absence of telomerase. WB:WBPaper00041021 WB:WBPerson7 Animals do not respond with sleeping behavior induced through the EGF pathway. The EGF-induced sleep pathway is thought to represent a distinct molecular pathway from developmentally linked sleep. The EGF-induced sleep state occurs in two contexts: by overexpressing the EGF ortholog (LIN-3C), or by EGF signaling after stress (such as temperature elevation) in wildtype animals. C_elegans_phenotype_ontology stressed-induced sleep variant WBPhenotype:0002432 EGF-induced sleep variant Animals do not respond with sleeping behavior induced through the EGF pathway. The EGF-induced sleep pathway is thought to represent a distinct molecular pathway from developmentally linked sleep. The EGF-induced sleep state occurs in two contexts: by overexpressing the EGF ortholog (LIN-3C), or by EGF signaling after stress (such as temperature elevation) in wildtype animals. WB:WBPaper00050011 WB:WBPerson712 Animals respond with sleeping behavior induced through the EGF pathway, more rigorously than control animals. The EGF-induced sleep pathway is thought to represent a distinct molecular pathway from developmentally linked sleep. The EGF-induced sleep state occurs in two contexts: by overexpressing the EGF ortholog (LIN-3C), or by EGF signaling after stress (such as temperature elevation) in wildtype animals. C_elegans_phenotype_ontology stressed-induced sleep resistant WBPhenotype:0002433 EGF-induced sleep resistant Animals respond with sleeping behavior induced through the EGF pathway, more rigorously than control animals. The EGF-induced sleep pathway is thought to represent a distinct molecular pathway from developmentally linked sleep. The EGF-induced sleep state occurs in two contexts: by overexpressing the EGF ortholog (LIN-3C), or by EGF signaling after stress (such as temperature elevation) in wildtype animals. WB:WBPaper00050011 WB:WBPerson712 Animals exhibit variations in their response to mitochondrial stress, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002434 mitochondrial stress response variant Animals exhibit variations in their response to mitochondrial stress, compared to controls. WB:WBPaper00027723 WB:WBPerson2987 Nematodes exposed to DNA damaging agents or conditions exhibit lower susceptibility to DNA damage than other animals. C_elegans_phenotype_ontology induced DNA damage resistant WBPhenotype:0002435 less susceptibility to induced DNA damage Nematodes exposed to DNA damaging agents or conditions exhibit lower susceptibility to DNA damage than other animals. WB:WBPerson712 Nematodes exposed to DNA damaging agents or conditions exhibit greater susceptibility to DNA damage than other animals. C_elegans_phenotype_ontology induced DNA damage hypersensitive WBPhenotype:0002436 high susceptibility to induced DNA damage Nematodes exposed to DNA damaging agents or conditions exhibit greater susceptibility to DNA damage than other animals. WB:WBPerson712 Animals exhibit variations in the expression of repetitive exogenous DNA compared to control. C_elegans_phenotype_ontology WBPhenotype:0002437 repetitive transgene expression variant Animals exhibit variations in the expression of repetitive exogenous DNA compared to control. WB:WBPaper00003822 WB:WBPerson2987 Animals exhibit reduced expression of repetitive exogenous DNA compared to control. C_elegans_phenotype_ontology WBPhenotype:0002438 repetitive transgene expression reduced Animals exhibit reduced expression of repetitive exogenous DNA compared to control. WB:WBPaper00003822 WB:WBPerson2987 Animals exhibit increased expression of repetitive exogenous DNA compared to control. C_elegans_phenotype_ontology WBPhenotype:0002439 repetitive transgene expression increased Animals exhibit increased expression of repetitive exogenous DNA compared to control. WB:WBPaper00003822 WB:WBPerson2987 Any perturbation that renders sperm incompetent at fertilizing an oocyte. C_elegans_phenotype_ontology WBPhenotype:0002440 sperm fertility defective Any perturbation that renders sperm incompetent at fertilizing an oocyte. WB:WBPerson2987 WB:WBPerson557 The time between two pumps of the pharynx is increased compared to control animals. C_elegans_phenotype_ontology pharyngeal inter-pumping interval increased WBPhenotype:0002441 pharyngeal inter-pump interval increased The time between two pumps of the pharynx is increased compared to control animals. WB:WBPaper00050613 WB:WBPerson712 The duration of the contraction of the pharyngeal muscle during pumping is increased compared to controls. C_elegans_phenotype_ontology pharyngeal pump extended WBPhenotype:0002442 pharyngeal pump duration increased The duration of the contraction of the pharyngeal muscle during pumping is increased compared to controls. WB:WBPaper00050613 WB:WBPerson712 Any variation in the specific actions or reactions of the male that are associated with the protraction of the male copulatory spicules compared to control. C_elegans_phenotype_ontology WBPhenotype:0002443 spicule protraction variant Any variation in the specific actions or reactions of the male that are associated with the protraction of the male copulatory spicules compared to control. WB:WBPerson557 Animals exhibit variations in the chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. pyrimidine base biosynthesis variant C_elegans_phenotype_ontology WBPhenotype:0002444 pyrimidine biosynthesis variant Animals exhibit variations in the chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. GO:0019856 WB:WBPerson324 WB:WBPerson557 Animals have one or more extra hypodermal cells, which are present in places they are normally not found, when compared to the number and location of these cells in control animals. C_elegans_phenotype_ontology WBPhenotype:0002445 extra and ectopic hypodermis Animals have one or more extra hypodermal cells, which are present in places they are normally not found, when compared to the number and location of these cells in control animals. WB:WBPaper00025033 WB:WBPerson2987 Animals exhibit variations in pharyngeal pumping rate in response to light, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002446 pharyngeal pumping rate in response to light variant Animals exhibit variations in pharyngeal pumping rate in response to light, compared to controls. WB:WBPaper00046411 WB:WBPaper00048388 WB:WBPerson2987 WB:WBPerson557 WB:WBPerson9765 Animals exhibit variations in the acute pharyngeal pumping response to light, during which the pharyngeal pumping rate initially (0-5 seconds after light exposure onset) decreases in response to light, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002447 acute pumping response to light variant Animals exhibit variations in the acute pharyngeal pumping response to light, during which the pharyngeal pumping rate initially (0-5 seconds after light exposure onset) decreases in response to light, compared to controls. WB:WBPaper00046411 WB:WBPaper00048388 WB:WBPerson2987 WB:WBPerson557 WB:WBPerson9765 Animals exhibit an enhanced acute pharyngeal pumping response to light, such that pharyngeal pumping rate decreases in response to light to a greater extent than in controls during the first 0-5 seconds after light exposure onset. C_elegans_phenotype_ontology WBPhenotype:0002448 enhanced acute pharyngeal pumping response to light Animals exhibit an enhanced acute pharyngeal pumping response to light, such that pharyngeal pumping rate decreases in response to light to a greater extent than in controls during the first 0-5 seconds after light exposure onset. WB:WBPaper00046411 WB:WBPaper00048388 WB:WBPerson2987 WB:WBPerson557 WB:WBPerson9765 Animals exhibit a reduced acute pharyngeal pumping response to light, such that pharyngeal pumping rate decreases in response to light to a lesser extent than in controls during the first 0-5 seconds after light exposure onset. C_elegans_phenotype_ontology WBPhenotype:0002449 reduced acute pharyngeal pumping response to light Animals exhibit a reduced acute pharyngeal pumping response to light, such that pharyngeal pumping rate decreases in response to light to a lesser extent than in controls during the first 0-5 seconds after light exposure onset. WB:WBPaper00046411 WB:WBPaper00048388 WB:WBPerson2987 WB:WBPerson557 WB:WBPerson9765 Animals exhibit variations in the burst pharyngeal pumping response to light, during which the pharyngeal pumping rate slightly increases during the5-10 seconds after light exposure onset, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002450 burst pharyngeal pumping response to light Animals exhibit variations in the burst pharyngeal pumping response to light, during which the pharyngeal pumping rate slightly increases during the5-10 seconds after light exposure onset, compared to controls. WB:WBPaper00046411 WB:WBPaper00048388 WB:WBPerson2987 WB:WBPerson557 WB:WBPerson9765 Animals exhibit an enhanced burst pharyngeal pumping response to light, such that during the5-10 seconds after light exposure onset the pharyngeal pumping rate increases to a greater extent than in controls. C_elegans_phenotype_ontology WBPhenotype:0002451 enhanced burst pharyngeal pumping response to light Animals exhibit an enhanced burst pharyngeal pumping response to light, such that during the5-10 seconds after light exposure onset the pharyngeal pumping rate increases to a greater extent than in controls. WB:WBPaper00046411 WB:WBPaper00048388 WB:WBPerson2987 WB:WBPerson557 WB:WBPerson9765 Animals exhibit a reduced burst pharyngeal pumping response to light, such that during the5-10 seconds after light exposure onset the pharyngeal pumping rate increases to a lesser extent than in controls. C_elegans_phenotype_ontology WBPhenotype:0002452 reduced burst pharyngeal pumping response to light Animals exhibit a reduced burst pharyngeal pumping response to light, such that during the5-10 seconds after light exposure onset the pharyngeal pumping rate increases to a lesser extent than in controls. WB:WBPaper00046411 WB:WBPaper00048388 WB:WBPerson2987 WB:WBPerson557 WB:WBPerson9765 Animals exhibit variations in the recovery pharyngeal pumping response to light, during which the pharyngeal pumping rate slowly increases during the 0-10 seconds afterremoval of light exposure, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002453 recovery pumping response to light variant Animals exhibit variations in the recovery pharyngeal pumping response to light, during which the pharyngeal pumping rate slowly increases during the 0-10 seconds afterremoval of light exposure, compared to controls. WB:WBPaper00046411 WB:WBPaper00048388 WB:WBPerson2987 WB:WBPerson557 WB:WBPerson9765 Animals exhibit an enhanced recovery pharyngeal pumping response to light, such that during the 0-10 seconds after removal of light exposure the pharyngeal pumping rate increases to a greater extent than in controls. C_elegans_phenotype_ontology WBPhenotype:0002454 enhanced recovery pumping response to light Animals exhibit an enhanced recovery pharyngeal pumping response to light, such that during the 0-10 seconds after removal of light exposure the pharyngeal pumping rate increases to a greater extent than in controls. WB:WBPaper00046411 WB:WBPaper00048388 WB:WBPerson2987 WB:WBPerson557 WB:WBPerson9765 Animals exhibit a reduced recovery pharyngeal pumping response to light, such that during the 0-10 seconds after removal of light exposure the pharyngeal pumping rate increasesto a lesser extent than in controls. C_elegans_phenotype_ontology WBPhenotype:0002455 reduced recovery pumping response to light Animals exhibit a reduced recovery pharyngeal pumping response to light, such that during the 0-10 seconds after removal of light exposure the pharyngeal pumping rate increasesto a lesser extent than in controls. WB:WBPaper00046411 WB:WBPaper00048388 WB:WBPerson2987 WB:WBPerson557 WB:WBPerson9765 Animals exhibit variations in the changes in calcium levels in response to light compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002456 calcium response to light variant Animals exhibit variations in the changes in calcium levels in response to light compared to controls. WB:WBPaper00048388 WB:WBPerson2987 WB:WBPerson557 WB:WBPerson9765 Formation in the male of the egg-laying organ of female and hermaphrodite nematodes. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. vulva in male C_elegans_phenotype_ontology WBPhenotype:0002457 ectopic vulva in male Formation in the male of the egg-laying organ of female and hermaphrodite nematodes. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. WB:WBPaper00026839 WB:WBPerson2987 Any variation in the form, structure or composition of any part of an animal caused by the perturbation of maternal gene products that are contributed to oogenesis and are required during embryogenesis. Mal C_elegans_phenotype_ontology maternal effect morphology abnormal WBPhenotype:0002458 maternal effect morphology variant Any variation in the form, structure or composition of any part of an animal caused by the perturbation of maternal gene products that are contributed to oogenesis and are required during embryogenesis. WB:WBPerson557 Animals exhibit hyperinduction of expression of an antimicrobial peptide after an infection, compared to control animals. Hipi C_elegans_phenotype_ontology WBPhenotype:0002459 hyperinduction of antimicrobial peptide expression after infection Animals exhibit hyperinduction of expression of an antimicrobial peptide after an infection, compared to control animals. WB:WBPaper00049531 WB:WBPerson168 WB:WBPerson2987 Animals exhibit no induction of expression of an antimicrobial peptide after an infection, unlike control animals. Nipi C_elegans_phenotype_ontology WBPhenotype:0002460 no induction of antimicrobial peptide expression after infection Animals exhibit no induction of expression of an antimicrobial peptide after an infection, unlike control animals. WB:WBPaper00038424 WB:WBPaper00040946 WB:WBPaper00049531 WB:WBPerson168 WB:WBPerson2987 Pathogens exhibit decreased adherence to the surface of host animals. C_elegans_phenotype_ontology WBPhenotype:0002461 pathogen adherence decreased Pathogens exhibit decreased adherence to the surface of host animals. WB:WBPerson2987 WB:WBPerson557 Pathogens exhibit increased adherence to the surface of host animals. C_elegans_phenotype_ontology WBPhenotype:0002462 pathogen adherence increased Pathogens exhibit increased adherence to the surface of host animals. WB:WBPaper00049531 WB:WBPerson168 WB:WBPerson2987 Male animals lack a copulatory hook. C_elegans_phenotype_ontology WBPhenotype:0002463 hookless Male animals lack a copulatory hook. WB:WBPaper00045644 WB:WBPerson557 WB:WBPerson625 Male animals exhibit multiple copulatory hooks. In wild type C. elegans males, a single hook is normally present. C_elegans_phenotype_ontology WBPhenotype:0002464 multiple hooks Male animals exhibit multiple copulatory hooks. In wild type C. elegans males, a single hook is normally present. WB:WBPaper00045644 WB:WBPerson557 WB:WBPerson625 The pattern or state of ubiquitin modifications of histones varies from that of controls. C_elegans_phenotype_ontology histone ubiquitylation variant WBPhenotype:0002465 histone ubiquitination variant The pattern or state of ubiquitin modifications of histones varies from that of controls. WB:WBPaper00053651 WB:WBPerson1370 WB:WBPerson557 Variations in the processes that incorporate methyl groups to one or more bases within RNA, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002466 RNA methylation variant Variations in the processes that incorporate methyl groups to one or more bases within RNA, compared to control. WB:WBPaper00049616 WB:WBPerson29150 WB:WBPerson557 Males continue to sire progeny significantly past the time reproduction stops in control animals or show a slower decline in mating efficiency compared to age-matched control males. C_elegans_phenotype_ontology WBPhenotype:0002467 male reproductive longevity extended Males continue to sire progeny significantly past the time reproduction stops in control animals or show a slower decline in mating efficiency compared to age-matched control males. WB:WBPaper00053333 WB:WBPerson557 Animals exhibit a reduction in the rate of the chemical reactions and pathways resulting in the formation of a protein, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002468 translation rate reduced Animals exhibit a reduction in the rate of the chemical reactions and pathways resulting in the formation of a protein, compared to control. GO:0006417 WB:WBPaper00046894 WB:WBPerson557 Any variation in the decrease in a behavioral response to a repeated plate tap stimulus compared to control. C_elegans_phenotype_ontology WBPhenotype:0002469 plate tap habituation variant Any variation in the decrease in a behavioral response to a repeated plate tap stimulus compared to control. WB:WBPaper00041802 WB:WBPerson3192 WB:WBPerson557 Animals exhibit variations in the length of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals. cilium length variant C_elegans_phenotype_ontology WBPhenotype:0002470 cilia length variant Animals exhibit variations in the length of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals. WB:WBPaper00053681 WB:WBPerson2136 WB:WBPerson557 Animals exhibit an increase in the length of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals. cilium length increased C_elegans_phenotype_ontology WBPhenotype:0002471 cilia length increased Animals exhibit an increase in the length of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals. WB:WBPaper00053681 WB:WBPerson2136 WB:WBPerson557 Animals exhibit a reduction in the length of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals. cilium length decreased C_elegans_phenotype_ontology WBPhenotype:0002472 cilia length decreased Animals exhibit a reduction in the length of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals. WB:WBPaper00053681 WB:WBPerson2136 WB:WBPerson557 Animals fail to undergo the cellular catabolic process in which cells digest parts of their own cytoplasm. autophagy defective C_elegans_phenotype_ontology WBPhenotype:0002473 autophagy block Animals fail to undergo the cellular catabolic process in which cells digest parts of their own cytoplasm. GO:0006914 WB:WBPaper00046758 WB:WBPerson2242 WB:WBPerson557 Animals are less prone to infection by virus compared to control. C_elegans_phenotype_ontology WBPhenotype:0002474 viral resistance increased Animals are less prone to infection by virus compared to control. WB:WBPaper00053019 WB:WBPerson24802 WB:WBPerson557 Animals vary in the distance between most anterior and the most posterior ends of the pharynx from that observed in control animals. pharyngeal length variant C_elegans_phenotype_ontology WBPhenotype:0002475 pharynx length variant Animals vary in the distance between most anterior and the most posterior ends of the pharynx from that observed in control animals. WB:WBPaper00049351 WB:WBPerson2693 WB:WBPerson557 Animals have an increase in the distance between most anterior and the most posterior ends of the pharynx from that observed in control animals. pharyngeal length increased pharynx elongation C_elegans_phenotype_ontology WBPhenotype:0002476 pharynx length increased Animals have an increase in the distance between most anterior and the most posterior ends of the pharynx from that observed in control animals. WB:WBPaper00049351 WB:WBPerson2693 WB:WBPerson557 Any variation in the subcellular localization of the ribosome compared to control. The ribosome is an intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). ribosome distribution variant C_elegans_phenotype_ontology WBPhenotype:0002477 ribosome localization variant Any variation in the subcellular localization of the ribosome compared to control. The ribosome is an intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). GO:0005840 WB:WBPaper00052855 WB:WBPerson15276 WB:WBPerson557 Any variation in the cellular and molecular pathways in a neuron in response to having its axon severed compared to severing in control animals. C_elegans_phenotype_ontology WBPhenotype:0002478 axotomy response variant Any variation in the cellular and molecular pathways in a neuron in response to having its axon severed compared to severing in control animals. WB:WBPaper00053323 WB:WBPerson557 WB:WBPerson9270 Any increase in regenerative regrowth of axons compared to control animals. axonal regeneration enhanced C_elegans_phenotype_ontology WBPhenotype:0002479 axon regeneration enhanced Any increase in regenerative regrowth of axons compared to control animals. WB:WBPaper00053323 WB:WBPerson557 WB:WBPerson9270 Animals exhibit variations in the amount of heme compared to control animals. Heme is any compound of iron complexed in a porphyrin (tetrapyrrole) ring. C_elegans_phenotype_ontology WBPhenotype:0002480 heme levels variant Animals exhibit variations in the amount of heme compared to control animals. Heme is any compound of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0006783 WB:WBPaper00049976 WB:WBPerson16107 WB:WBPerson2987 WB:WBPerson557 Animals exhibit a decrease in the amount of heme compared to control animals. Heme is any compound of iron complexed in a porphyrin (tetrapyrrole) ring. heme levels reduced C_elegans_phenotype_ontology WBPhenotype:0002481 heme levels decreased Animals exhibit a decrease in the amount of heme compared to control animals. Heme is any compound of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0006783 WB:WBPaper00049976 WB:WBPerson16107 WB:WBPerson2987 WB:WBPerson557 Animals exhibit an increase in the amount of heme compared to control animals. Heme is any compound of iron complexed in a porphyrin (tetrapyrrole) ring. C_elegans_phenotype_ontology WBPhenotype:0002482 heme levels increased Animals exhibit an increase in the amount of heme compared to control animals. Heme is any compound of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0006783 WB:WBPaper00049976 WB:WBPerson16107 WB:WBPerson2987 WB:WBPerson557 Animals are less prone to infection by a fungus compared to control. C_elegans_phenotype_ontology WBPhenotype:0002483 fungal resistance increased Animals are less prone to infection by a fungus compared to control. WB:WBPaper00046695 WB:WBPerson557 Animals exhibit variations in fluidity of cell membranes, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002484 membrane fluidity variant Animals exhibit variations in fluidity of cell membranes, compared to control animals. WB:WBPaper00055850 WB:WBPerson2987 Any variation in the morphological appearance of germline precursor cells compared to control animals. C_elegans_phenotype_ontology primordial germ cell morphology variant WBPhenotype:0002485 germline precursor cell morphology variant Any variation in the morphological appearance of germline precursor cells compared to control animals. WB:WBPaper00050421 WB:WBPerson2987 Animals exhibit persistent cellular lobes of the primordial germ cells Z2 and/or Z3 at the L1 larval stage or later, in contrast to wild type animals C_elegans_phenotype_ontology persistent germline precursor cell lobes WBPhenotype:0002486 persistent primordial germ cell lobes Animals exhibit persistent cellular lobes of the primordial germ cells Z2 and/or Z3 at the L1 larval stage or later, in contrast to wild type animals WB:WBPaper00050421 WB:WBPerson2987 WB:WBPerson35710 Animals exhibit variations in the integrity of the intestine, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002487 intestinal integrity variant Animals exhibit variations in the integrity of the intestine, compared to controls. WB:WBPaper00049837 WB:WBPerson2987 Animals exhibit an increase in the integrity of the intestine, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002488 intestinal integrity increased Animals exhibit an increase in the integrity of the intestine, compared to controls. WB:WBPaper00049837 WB:WBPerson14863 WB:WBPerson2987 Animals exhibit a reduction in the integrity of the intestine, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002489 intestinal integrity reduced Animals exhibit a reduction in the integrity of the intestine, compared to controls. WB:WBPerson2987 Neurons exhibit axon outgrowth in locations not normally found in controls. C_elegans_phenotype_ontology WBPhenotype:0002490 ectopic axon outgrowth Neurons exhibit axon outgrowth in locations not normally found in controls. WB:WBPaper00004283 WB:WBPaper00006029 WB:WBPaper00026706 WB:WBPaper00027335 WB:WBPaper00031901 WB:WBPaper00032090 WB:WBPerson2987 Neurons exhibit neurite outgrowth in locations not normally found in controls. C_elegans_phenotype_ontology WBPhenotype:0002491 ectopic neurite outgrowth Neurons exhibit neurite outgrowth in locations not normally found in controls. WB:WBPaper00003665 WB:WBPaper00004340 WB:WBPaper00027335 WB:WBPerson2987 Animals exhibit one or more body wall muscle cells in locations not normally found in controls. C_elegans_phenotype_ontology WBPhenotype:0002492 ectopic body wall muscle Animals exhibit one or more body wall muscle cells in locations not normally found in controls. WB:WBPaper00035201 WB:WBPerson2987 Animals exhibit one or more cells of a particular type in locations not normally found in controls. C_elegans_phenotype_ontology WBPhenotype:0002493 ectopic cell Animals exhibit one or more cells of a particular type in locations not normally found in controls. WB:WBPaper00003331 WB:WBPaper00003719 WB:WBPerson2987 Animals exhibit one or more endodermal cells in locations not normally found in controls. C_elegans_phenotype_ontology WBPhenotype:0002494 ectopic endoderm Animals exhibit one or more endodermal cells in locations not normally found in controls. WB:WBPaper00002871 WB:WBPaper00003645 WB:WBPerson2987 Animals exhibit one or more hypodermal cells in locations not normally found in controls. C_elegans_phenotype_ontology WBPhenotype:0002495 ectopic hypodermis Animals exhibit one or more hypodermal cells in locations not normally found in controls. WB:WBPaper00025033 WB:WBPerson2987 Animals exhibit one or more neurons in locations not normally found in controls. C_elegans_phenotype_ontology WBPhenotype:0002496 ectopic neuron Animals exhibit one or more neurons in locations not normally found in controls. WB:WBPaper00000635 WB:WBPaper00027335 WB:WBPerson2987 Animals exhibit one or more pharyngeal muscle cells in locations not normally found in controls. C_elegans_phenotype_ontology WBPhenotype:0002497 ectopic pharyngeal muscle Animals exhibit one or more pharyngeal muscle cells in locations not normally found in controls. WB:WBPaper00003574 WB:WBPaper00003645 WB:WBPerson2987 Animals exhibit one or more organs of a particular type in locations not normally found in controls. C_elegans_phenotype_ontology WBPhenotype:0002498 ectopic organ Animals exhibit one or more organs of a particular type in locations not normally found in controls. WB:WBPaper00031604 WB:WBPerson2987 Animals exhibit one or more vulvae in locations not normally found in controls. C_elegans_phenotype_ontology WBPhenotype:0002499 ectopic vulva Animals exhibit one or more vulvae in locations not normally found in controls. WB:WBPaper00031604 WB:WBPerson2987 One or more cells exhibit one or more cleavage furrows in locations not normally found in control cells. C_elegans_phenotype_ontology WBPhenotype:0002500 ectopic cleavage furrow One or more cells of the early embryo (one-cell stage to four-cell stage) exhibit one or more cleavage furrows in locations not normally found in control cells. C_elegans_phenotype_ontology WBPhenotype:0002501 ectopic cleavage furrow early emb One or more cells of the early embryo (one-cell stage to four-cell stage) exhibit one or more cleavage furrows in locations not normally found in control cells. WB:WBPaper00005599 WB:WBPaper00006061 WB:WBPaper00030892 WB:WBPaper00033469 WB:WBPerson2987 Animals exhibit an increase in the covalent addition of an acetyl group to one or more native amino acid side chains in proteins. C_elegans_phenotype_ontology WBPhenotype:0002502 protein acetylation increased Animals exhibit an increase in the covalent addition of an acetyl group to one or more native amino acid side chains in proteins. WB:WBPaper00046534 WB:WBPerson113 WB:WBPerson2987 Animals exhibit an increase the creation of double-strand breaks that occur during meiosis that may result in the initiation of meiotic recombination. C_elegans_phenotype_ontology WBPhenotype:0002503 meiotic DNA double strand break formation increased Animals exhibit an increase the creation of double-strand breaks that occur during meiosis that may result in the initiation of meiotic recombination. WB:WBPaper00046534 WB:WBPerson113 WB:WBPerson2987 Infected animals exhibit a reduction in the release of pathogens back into the environment, compared to control. spore shedding reduced C_elegans_phenotype_ontology WBPhenotype:0002504 pathogen release reduced Infected animals exhibit a reduction in the release of pathogens back into the environment, compared to control. WB:WBPaper00040246 WB:WBPaper00045292 WB:WBPerson2987 WB:WBPerson3965 Infected animals exhibit variations in the clearance of pathogen infection compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002505 pathogen infection clearance variant Infected animals exhibit variations in the clearance of pathogen infection compared to controls. WB:WBPaper00044624 WB:WBPerson2706 WB:WBPerson2987 Infected animals exhibit an increased rate of clearance of pathogen infection compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002506 pathogen infection clearance rate increased Infected animals exhibit an increased rate of clearance of pathogen infection compared to controls. WB:WBPaper00044624 WB:WBPerson2706 WB:WBPerson2987 Infected animals exhibit a decreased rate of clearance of pathogen infection compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002507 pathogen infection clearance rate decreased Infected animals exhibit a decreased rate of clearance of pathogen infection compared to controls. WB:WBPaper00044624 WB:WBPerson2706 WB:WBPerson2987 Animals produce an excess number of neurons compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002508 extra neuron Animals produce an excess number of neurons compared to controls. WB:WBPaper00053165 WB:WBPerson2987 WB:WBPerson3252 Animals produce an excess number of dopaminergic neurons compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002509 extra dopaminergic neuron Animals produce an excess number of dopaminergic neurons compared to controls. WB:WBPaper00053165 WB:WBPerson2987 WB:WBPerson3252 Animals exhibit fewer neurons compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002510 fewer neurons Animals exhibit fewer neurons compared to control animals. WB:WBPaper00053165 WB:WBPerson2987 WB:WBPerson3252 Animals exhibit fewer glutamatergic neurons compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002511 fewer glutamatergic neurons Animals exhibit fewer glutamatergic neurons compared to control animals. WB:WBPaper00053165 WB:WBPerson2987 WB:WBPerson3252 Variations in behavior that is dependent upon the sensation of temperature, compared to control. thermosensory behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0002512 thermosensory behavior variant Variations in behavior that is dependent upon the sensation of temperature, compared to control. GO:0040040 WB:WBPerson2987 Any variation in the directed movement of a worm in response to a specific temperature gradient compared to control. C_elegans_phenotype_ontology WBPhenotype:0002513 thermotaxis variant Any variation in the directed movement of a worm in response to a specific temperature gradient compared to control. GO:0043052 WB:WBPerson2987 Animals do not exhibit backward locomotion under conditions that induce backward locomotion in control animals. C_elegans_phenotype_ontology WBPhenotype:0002514 backing absent Animals do not exhibit backward locomotion under conditions that induce backward locomotion in control animals. WB:WBPerson261 WB:WBPerson2987 Animals exhibit a defective response to pathogens. C_elegans_phenotype_ontology WBPhenotype:0002515 organism pathogen response defective Animals exhibit a defective response to pathogens. WB:WBPaper00055957 WB:WBPerson2987 WB:WBPerson919 Animals exhibit variations, compared to control, in the distance traveled in a burrowing assay, in which animals are placed in a tube, separated from an attractant by solid medium through which the worms can burrow. Variations in distance traveled during the burrowing assay, when controlled for chemosensation defects, have been suggested to reflect variations in neuromuscular efficacy of locomotion. C_elegans_phenotype_ontology WBPhenotype:0002516 burrowing assay distance abnormal Animals exhibit variations, compared to control, in the distance traveled in a burrowing assay, in which animals are placed in a tube, separated from an attractant by solid medium through which the worms can burrow. Variations in distance traveled during the burrowing assay, when controlled for chemosensation defects, have been suggested to reflect variations in neuromuscular efficacy of locomotion. WB:WBPaper00046657 WB:WBPaper00056369 WB:WBPerson2987 WB:WBPerson9270 Animals exhibit a reduction, compared to control, in the distance traveled in a burrowing assay, in which animals are placed in a tube, separated from an attractant by solid medium through which the worms can burrow. Reductions in distance traveled during the burrowing assay, when controlled for chemosensation defects, have been suggested to reflect deficits in neuromuscular efficacy of locomotion. C_elegans_phenotype_ontology WBPhenotype:0002517 burrowing assay distance reduced Animals exhibit a reduction, compared to control, in the distance traveled in a burrowing assay, in which animals are placed in a tube, separated from an attractant by solid medium through which the worms can burrow. Reductions in distance traveled during the burrowing assay, when controlled for chemosensation defects, have been suggested to reflect deficits in neuromuscular efficacy of locomotion. WB:WBPaper00046657 WB:WBPaper00056369 WB:WBPerson2987 WB:WBPerson9270 The length of one or more axons is abnormal compared to the length of the corresponding axon(s) in control animals. C_elegans_phenotype_ontology WBPhenotype:0002518 axon length abnormal The length of one or more axons is abnormal compared to the length of the corresponding axon(s) in control animals. WB:WBPaper00056369 WB:WBPerson2987 WB:WBPerson9270 The length of one or more axons is reduced compared to the length of the corresponding axon(s) in control animals. short axon C_elegans_phenotype_ontology WBPhenotype:0002519 axon length reduced The length of one or more axons is reduced compared to the length of the corresponding axon(s) in control animals. WB:WBPaper00056369 WB:WBPerson2987 WB:WBPerson9270 One or more cells exhibit variations in the morphology of one or more gap junction plaques, sets of associated gap junctions, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002520 gap junction plaque morphology abnormal One or more cells exhibit variations in the morphology of one or more gap junction plaques, sets of associated gap junctions, compared to controls. WB:WBPaper00049389 WB:WBPerson2987 WB:WBPerson30255 One or more cells exhibit an increase in number of gap junction plaques, sets of associated gap junctions, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002521 gap junction plaque number increased One or more cells exhibit an increase in number of gap junction plaques, sets of associated gap junctions, compared to controls. WB:WBPaper00049389 WB:WBPerson2987 WB:WBPerson30255 Animals exhibit variations in the recovery from L1 larvae developmental arrest in response to a lack of food (starvation) available in the environment. C_elegans_phenotype_ontology WBPhenotype:0002522 starvation-induced L1 arrest recovery abnormal Animals exhibit variations in the recovery from L1 larvae developmental arrest in response to a lack of food (starvation) available in the environment. WB:WBPaper00049938 WB:WBPerson2987 WB:WBPerson6498 Animals exhibit a slow recovery from starvation-induced L1 arrest, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002523 slow recovery from starvation-induced L1 arrest Animals exhibit a slow recovery from starvation-induced L1 arrest, compared to controls. WB:WBPaper00049938 WB:WBPerson2987 WB:WBPerson34124 WB:WBPerson6498 Animals are more sensitive to the depletion of molybdenum cofactor from the diet compared to control animals. dependent on dietary molybdenum cofactor C_elegans_phenotype_ontology WBPhenotype:0002524 molybdenum cofactor depletion hypersensitive Animals are more sensitive to the depletion of molybdenum cofactor from the diet compared to control animals. WB:WBPaper00056452 WB:WBPerson2987 Animals exhibit variations in their response to diet, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002525 diet response variant Animals exhibit variations in their response to diet, compared to controls. WB:WBPaper00024451 WB:WBPaper00026641 WB:WBPaper00032936 WB:WBPaper00045849 WB:WBPaper00056452 WB:WBPerson2987 Animals exhibit variations in the response to the depletion of molybdenum cofactor from the diet compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002526 response to molybdenum cofactor depletion abnormal Animals exhibit variations in the response to the depletion of molybdenum cofactor from the diet compared to control animals. WB:WBPaper00056452 WB:WBPerson2987 Animals in the dauer larval stage exhibit variations in their physiology (any biological process including but not limited to development, behavior, or metabolism) compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002527 dauer larva physiology variant Animals in the dauer larval stage exhibit variations in their physiology (any biological process including but not limited to development, behavior, or metabolism) compared to controls. WB:WBPaper00004052 WB:WBPerson2987 Animals (or cells) exhibit defects in the ability to produce mature microRNAs (miRNAs) from a miRNA locus. The defects could be at the level of miRNA transcription, pri-miRNA processing, and/or pre-miRNA processing. C_elegans_phenotype_ontology WBPhenotype:0002528 miRNA biogenesis defective Animals (or cells) exhibit defects in the ability to produce mature microRNAs (miRNAs) from a miRNA locus. The defects could be at the level of miRNA transcription, pri-miRNA processing, and/or pre-miRNA processing. WB:WBPaper00041677 WB:WBPerson2987 WB:WBPerson5649 Animals exhibit defects or impairments in the functioning of the proteasome. C_elegans_phenotype_ontology WBPhenotype:0002529 proteasome defective Animals exhibit defects or impairments in the functioning of the proteasome. WB:WBPaper00056554 WB:WBPerson2987 WB:WBPerson5649 The level of phosphatidylserine exposed on the external axonal membrane following transection (axotomy) is changed compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002530 axotomy-induced phosphatidylserine exposure abnormal The level of phosphatidylserine exposed on the external axonal membrane following transection (axotomy) is changed compared to controls. WB:WBPaper00053570 WB:WBPerson2987 WB:WBPerson9270 Animals exhibit variations in allogenic (non-self) organelle autophagy, or allophagy, a macroautophagy process whereby organelles of non-self origin, like paternal mitochondria from sperm in a newly fertilized oocyte, are selectively degraded. C_elegans_phenotype_ontology WBPhenotype:0002531 allophagy abnormal Animals exhibit variations in allogenic (non-self) organelle autophagy, or allophagy, a macroautophagy process whereby organelles of non-self origin, like paternal mitochondria from sperm in a newly fertilized oocyte, are selectively degraded. WB:WBPaper00040312 WB:WBPaper00041104 WB:WBPaper00053507 WB:WBPerson2987 WB:WBPerson3859 Animals exhibit defects in allogenic (non-self) organelle autophagy, or allophagy, a macroautophagy process whereby organelles of non-self origin, like paternal mitochondria from sperm in a newly fertilized oocyte, are selectively degraded. C_elegans_phenotype_ontology WBPhenotype:0002532 allophagy defective Animals exhibit defects in allogenic (non-self) organelle autophagy, or allophagy, a macroautophagy process whereby organelles of non-self origin, like paternal mitochondria from sperm in a newly fertilized oocyte, are selectively degraded. WB:WBPaper00053507 WB:WBPerson2987 WB:WBPerson3859 Animals exhibit variations in the expression of one or more known, endogenous, antimicrobial genes, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002534 antimicrobial gene expression variant Animals exhibit variations in the expression of one or more known, endogenous, antimicrobial genes, compared to controls. WB:WBPaper00031865 WB:WBPerson2987 Animals exhibit variations in the extent to which one or more sensory neurons associated with sensilla (typically one or more amphids and/or phasmids) take up dye from the environment, compared to controls. In C. elegans, these neurons are commonly assayed by dye-filling with FITC, DiI or DiO. Dyf dye filling abnormal C_elegans_phenotype_ontology WBPhenotype:0002535 dye filling defect Animals exhibit variations in the extent to which one or more sensory neurons associated with sensilla (typically one or more amphids and/or phasmids) take up dye from the environment, compared to controls. In C. elegans, these neurons are commonly assayed by dye-filling with FITC, DiI or DiO. WB:WBPaper00000793 WB:WBPerson2987 Animals exhibit germ cells with a number of P granules that differs from control animals. C_elegans_phenotype_ontology WBPhenotype:0002536 P granule number abnormal Animals exhibit germ cells with a number of P granules that differs from control animals. WB:WBPaper00044160 WB:WBPerson2987 WB:WBPerson557 Animals exhibit germ cells with a reduced number of P granules compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002537 P granule number reduced Animals exhibit germ cells with a reduced number of P granules compared to control animals. WB:WBPaper00044160 WB:WBPerson2987 WB:WBPerson557 Any variation in the series of molecular signals in which the spermatheca uses calcium ions to convert an extracellular signal into a response, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002538 calcium signaling in spermatheca variant Any variation in the series of molecular signals in which the spermatheca uses calcium ions to convert an extracellular signal into a response, compared to control. WB:WBPaper00056137 WB:WBPerson2987 WB:WBPerson30989 Animals exhibit an increase in the expression of one or more known, endogenous, antimicrobial genes, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002539 antimicrobial gene expression increased Animals exhibit an increase in the expression of one or more known, endogenous, antimicrobial genes, compared to controls. WB:WBPaper00047109 WB:WBPerson15627 WB:WBPerson2987 Animals exhibit a reduced rate of lawn/food leaving events, compared to controls. food leaving reduced C_elegans_phenotype_ontology WBPhenotype:0002540 lawn leaving reduced Animals exhibit a reduced rate of lawn/food leaving events, compared to controls. WB:WBPaper00053007 WB:WBPerson262 WB:WBPerson2987 Programmed cell death of germ cells caused by exposure to ionizing energy occurs to a lesser extent than it does in control animals. C_elegans_phenotype_ontology WBPhenotype:0002541 radiation induced germ cell apoptosis resistant Programmed cell death of germ cells caused by exposure to ionizing energy occurs to a lesser extent than it does in control animals. WB:WBPaper00032243 WB:WBPaper00032356 WB:WBPerson2987 Cells exhibit specific regions of chromatin (e.g. an integrated array reporter) that localize to different regions within the nucleus, compared to controls. intranuclear chromatin localization abnormal C_elegans_phenotype_ontology WBPhenotype:0002542 intranuclear chromatin localization variant Cells exhibit specific regions of chromatin (e.g. an integrated array reporter) that localize to different regions within the nucleus, compared to controls. WB:WBPaper00056796 WB:WBPerson2987 WB:WBPerson32254 Animals accumulate a greater number of mitochondrial genetic lesions than control animals in the absence of an externally controlled mutagen. C_elegans_phenotype_ontology WBPhenotype:0002543 spontaneous mitochondrial DNA mutation rate increased Animals accumulate a greater number of mitochondrial genetic lesions than control animals in the absence of an externally controlled mutagen. WB:WBPaper00053883 WB:WBPerson2987 WB:WBPerson31184 Normally beneficial (or otherwise harmless, non-pathogenic) commensal Enterobacter bacteria, for example Enterobacter cloacae, become pathogenic to animals, unlike in control animals. C_elegans_phenotype_ontology WBPhenotype:0002544 hypersensitive to Enterobacter commensals Normally beneficial (or otherwise harmless, non-pathogenic) commensal Enterobacter bacteria, for example Enterobacter cloacae, become pathogenic to animals, unlike in control animals. WB:WBPaper00056139 WB:WBPerson2987 WB:WBPerson3878 Animals exhibit variations in their response to bacteria (pathogenic or non-pathogenic), compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002545 response to bacteria variant Animals exhibit variations in their response to bacteria (pathogenic or non-pathogenic), compared to controls. WB:WBPaper00056139 WB:WBPerson2987 WB:WBPerson3878 Animals exhibit variations in the load of bacteria, of a particular clade or in general, in the gut, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002546 bacterial load in gut variant Animals exhibit variations in the load of bacteria, of a particular clade or in general, in the gut, compared to controls. WB:WBPaper00056139 WB:WBPerson2987 WB:WBPerson3878 Animals exhibit a greater abundance of bacteria of the Enterobacteriaceae family in the gut, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002547 gut Enterobacteriaceae bloom Animals exhibit a greater abundance of bacteria of the Enterobacteriaceae family in the gut, compared to controls. WB:WBPaper00056139 WB:WBPerson2987 WB:WBPerson3878 Animals exhibit a kinker phenotype that is due to conflicting, simultaneous forward and backward propagating bending waves. conflicted kinker C_elegans_phenotype_ontology WBPhenotype:0002548 kinker from conflicting forward and backward body bend propagation Animals exhibit a kinker phenotype that is due to conflicting, simultaneous forward and backward propagating bending waves. WB:WBPaper00040432 WB:WBPerson2987 WB:WBPerson720 Animals exhibit an increase in the rate at which spontaneous backward locomotion is initiated compared to control. C_elegans_phenotype_ontology WBPhenotype:0002549 increased frequency of spontaneous reversal initiation Animals exhibit an increase in the rate at which spontaneous backward locomotion is initiated compared to control. WB:WBPaper00040432 WB:WBPerson2987 WB:WBPerson720 Animals exhibit a kinker phenotype that is due to conflicting, simultaneous forward and backward propagating bending waves, and over time has a tendency to move slowly backward due to a dominating reversal neural circuit. C_elegans_phenotype_ontology WBPhenotype:0002550 conflicted kinker with gradual backward movement Animals exhibit a kinker phenotype that is due to conflicting, simultaneous forward and backward propagating bending waves, and over time has a tendency to move slowly backward due to a dominating reversal neural circuit. WB:WBPaper00040432 WB:WBPerson2987 WB:WBPerson720 A phenotype affecting a particular anatomical entity. C_elegans_phenotype_ontology WBPhenotype:0002551 anatomical phenotype A phenotype affecting a particular anatomical entity. WB:WBPerson2987 A phenotype affecting a particular cell. C_elegans_phenotype_ontology WBPhenotype:0002552 cell phenotype A phenotype affecting a particular cell. WB:WBPerson2987 A phenotype affecting a particular organ. C_elegans_phenotype_ontology WBPhenotype:0002553 organ phenotype A phenotype affecting a particular organ. WB:WBPerson2987 A phenotype affecting a particular organ system. C_elegans_phenotype_ontology WBPhenotype:0002554 organ system phenotype A phenotype affecting a particular organ system. WB:WBPerson2987 A phenotype affecting the whole organism. C_elegans_phenotype_ontology WBPhenotype:0002555 organismal phenotype A phenotype affecting the whole organism. WB:WBPerson2987 A phenotype affecting a particular tissue. C_elegans_phenotype_ontology WBPhenotype:0002556 tissue phenotype A phenotype affecting a particular tissue. WB:WBPerson2987 A phenotype affecting a particular body region. C_elegans_phenotype_ontology WBPhenotype:0002557 body region phenotype A phenotype affecting a particular body region. WB:WBPerson2987 A phenotype affecting a particular extracellular component. C_elegans_phenotype_ontology WBPhenotype:0002558 extracellular component phenotype A phenotype affecting a particular extracellular component. WB:WBPerson2987 Animals exhibit abnormalities in their burrowing behavior, in which animals burrow into a solid medium, such as agar, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002559 burrowing abnormal Animals exhibit abnormalities in their burrowing behavior, in which animals burrow into a solid medium, such as agar, compared to control animals. WB:WBPerson2987 Greater quantities of worms burrow into and stay below the surface of the agar when high densities of nematodes are maintained on agar compared to controls (Hodgkin and Doniach, 1997). C_elegans_phenotype_ontology WBPhenotype:0002560 burrowing in response to high population density increased Greater quantities of worms burrow into and stay below the surface of the agar when high densities of nematodes are maintained on agar compared to controls (Hodgkin and Doniach, 1997). WB:WBPaper00058743 WB:WBPerson2987 WB:WBPerson712 WB:WBPaper00002770 Cells exhibit defects in the homotypic fusion of endosomes. WBPhenotype:0001638 C_elegans_phenotype_ontology WBPhenotype:0002561 homotypic endosome fusion defective Cells exhibit defects in the homotypic fusion of endosomes. GO:0034058 WB:WBPaper00029049 WB:WBPerson2987 Cells exhibit variations or abnormalities in their maintenance of lysosome function, compared to controls. WBPhenotype:0001784 C_elegans_phenotype_ontology WBPhenotype:0002562 lysosome homeostasis abnormal Cells exhibit variations or abnormalities in their maintenance of lysosome function, compared to controls. WB:WBPaper00029049 WB:WBPerson2987 Animals exhibit variations in any physical or chemical process required for the neuron to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals. WBPhenotype:0000991 neuron physiology abnormal neuron physiology variant C_elegans_phenotype_ontology WBPhenotype:0002563 neuron physiology phenotype Animals exhibit variations in any physical or chemical process required for the neuron to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals. WB:WBPerson2987 Animals exhibit variations in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms, compared to controls. associative memory abnormal associative memory variant C_elegans_phenotype_ontology WBPhenotype:0002564 associative memory phenotype Animals exhibit variations in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms, compared to controls. WB:WBPaper00036296 WB:WBPerson2987 Animals exhibit variations in their recalled and repeated responses to olfactory stimuli they are exposed to during learning and memory paradigms, compared to controls. olfactory memory abnormal olfactory memory variant C_elegans_phenotype_ontology WBPhenotype:0002565 associative olfactory memory phenotype Animals exhibit variations in their recalled and repeated responses to olfactory stimuli they are exposed to during learning and memory paradigms, compared to controls. WB:WBPaper00036296 WB:WBPerson2987 WB:WBPerson3142 Animals exhibit variations in their recalled and repeated responses to olfactory stimuli they are exposed to during learning and memory paradigms over the long term, compared to controls. Long-term associative memory is memory that lasts for hours to days after the associative learning (training) event(s). long-term associative olfactory memory abnormal long-term associative olfactory memory variant C_elegans_phenotype_ontology WBPhenotype:0002566 long-term associative olfactory memory phenotype Animals exhibit variations in their recalled and repeated responses to olfactory stimuli they are exposed to during learning and memory paradigms over the long term, compared to controls. Long-term associative memory is memory that lasts for hours to days after the associative learning (training) event(s). WB:WBPaper00036296 WB:WBPerson2987 WB:WBPerson3142 Animals are deficient in their recalled and repeated responses to olfactory stimuli they are exposed to during learning and memory paradigms over the long term, compared to controls. Long-term associative memory is memory that lasts for hours to days after the associative learning (training) event(s). C_elegans_phenotype_ontology WBPhenotype:0002567 long-term associative olfactory memory defective Animals are deficient in their recalled and repeated responses to olfactory stimuli they are exposed to during learning and memory paradigms over the long term, compared to controls. Long-term associative memory is memory that lasts for hours to days after the associative learning (training) event(s). WB:WBPaper00036296 WB:WBPerson2987 WB:WBPerson3142 Animals exhibit variations in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms over the long term, compared to controls. Long-term associative memory is memory that lasts for hours to days after the associative learning (training) event(s). long-term associative memory abnormal long-term associative memory variant C_elegans_phenotype_ontology WBPhenotype:0002568 long-term associative memory phenotype Animals exhibit variations in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms over the long term, compared to controls. Long-term associative memory is memory that lasts for hours to days after the associative learning (training) event(s). WB:WBPaper00036296 WB:WBPerson2987 WB:WBPerson3142 Any variation in the progression of the hypodermis over time, from its formation to its mature state compared to control. hypodermal development abnormal hypodermal development variant hypodermis development abnormal C_elegans_phenotype_ontology WBPhenotype:0002569 hypodermis development variant Any variation in the progression of the hypodermis over time, from its formation to its mature state compared to control. WB:WBPerson2987 Cessation of development during the gastrulation stage of embryonic development. In C. elegans, gastrulation occurs 100-290 minutes after first cleavage at 20 degrees Centigrade when the embryo develops from 28 cells to 421 cells (during the proliferating embryo life stage). C_elegans_phenotype_ontology WBPhenotype:0002570 embryonic arrest during gastrulation Cessation of development during the gastrulation stage of embryonic development. In C. elegans, gastrulation occurs 100-290 minutes after first cleavage at 20 degrees Centigrade when the embryo develops from 28 cells to 421 cells (during the proliferating embryo life stage). WB:WBPerson2987 WB:WBPerson6609 Embryos exhibit a failure to enclose the anterior embryo region with hypodermis during the comma to early elongation stage of embryonic development. C_elegans_phenotype_ontology WBPhenotype:0002571 anterior enclosure defective Embryos exhibit a failure to enclose the anterior embryo region with hypodermis during the comma to early elongation stage of embryonic development. WB:WBPerson2987 WB:WBPerson6609 Animals exhibit variations in mitophagy, the selective autophagy process in which a mitochondrion is degraded by macroautophagy, compared to control. mitophagy variant C_elegans_phenotype_ontology WBPhenotype:0002572 mitophagy abnormal Animals exhibit variations in mitophagy, the selective autophagy process in which a mitochondrion is degraded by macroautophagy, compared to control. WB:WBPaper00056229 WB:WBPerson27070 WB:WBPerson2987 Animals exhibit reduced levels of mitophagy, the selective autophagy process in which a mitochondrion is degraded by macroautophagy, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002573 mitophagy reduced Animals exhibit reduced levels of mitophagy, the selective autophagy process in which a mitochondrion is degraded by macroautophagy, compared to control. WB:WBPaper00056229 WB:WBPerson27070 WB:WBPerson2987 Animals exhibit abnormal amounts of variation in gene expression level between individual animals, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002574 gene expression level variation abnormal Animals exhibit abnormal amounts of variation in gene expression level between individual animals, compared to control. WB:WBPaper00050756 WB:WBPerson2987 WB:WBPerson5662 Animals exhibit abnormal gene expression levels, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002575 gene expression level abnormal Animals exhibit abnormal gene expression levels, compared to control. WB:WBPerson2987 Animals exhibit reduced amounts of variation in gene expression level between individual animals, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002576 gene expression level variation reduced Animals exhibit reduced amounts of variation in gene expression level between individual animals, compared to control. WB:WBPaper00050756 WB:WBPerson2987 WB:WBPerson5662 Animals exhibit variations in the composition of basement membranes, compared to control animals. basement membrane composition abnormal basement membrane composition variant C_elegans_phenotype_ontology WBPhenotype:0002577 basement membrane composition phenotype Animals exhibit variations in the composition of basement membranes, compared to control animals. WB:WBPaper00057139 WB:WBPerson2987 WB:WBPerson32869 Animals exhibit variations in the amount of laminin in basement membranes, compared to control animals. basement membrane laminin level abnormal basement membrane laminin level variant C_elegans_phenotype_ontology WBPhenotype:0002578 basement membrane laminin level phenotype Animals exhibit variations in the amount of laminin in basement membranes, compared to control animals. WB:WBPaper00057139 WB:WBPerson2987 WB:WBPerson32869 Animals exhibit variations in the amount of type IV collagen in basement membranes, compared to control animals. basement membrane type IV collagen level abnormal basement membrane type IV collagen level variant C_elegans_phenotype_ontology WBPhenotype:0002579 basement membrane type IV collagen level phenotype Animals exhibit variations in the amount of type IV collagen in basement membranes, compared to control animals. WB:WBPaper00057139 WB:WBPerson2987 WB:WBPerson32869 One or more cells exhibit changes in the variability of cell position, compared to controls. cell position variability abnormal cell position variability variant C_elegans_phenotype_ontology WBPhenotype:0002580 cell position variability phenotype One or more cells exhibit changes in the variability of cell position, compared to controls. WB:WBPaper00056010 WB:WBPerson13958 WB:WBPerson2987 One or more cells exhibit increases in the variability of cell position, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002581 cell position variability increased One or more cells exhibit increases in the variability of cell position, compared to controls. WB:WBPaper00056010 WB:WBPerson13958 WB:WBPerson2987 Animals exhibit variations in miniature inhibitory post-synaptic currents (mIPSC), compared to controls. mIPSC abnormal mIPSC phenotype mIPSC variant miniature inhibitory post-synaptic current abnormal miniature inhibitory post-synaptic current variant C_elegans_phenotype_ontology WBPhenotype:0002582 miniature inhibitory post-synaptic current phenotype Animals exhibit variations in miniature inhibitory post-synaptic currents (mIPSC), compared to controls. WB:WBPaper00048837 WB:WBPerson18607 WB:WBPerson2987 Animals exhibit increased amplitude of miniature inhibitory post-synaptic currents (mIPSC), compared to controls. mIPSC amplitude increased C_elegans_phenotype_ontology WBPhenotype:0002583 miniature inhibitory post-synaptic current amplitude increased Animals exhibit increased amplitude of miniature inhibitory post-synaptic currents (mIPSC), compared to controls. WB:WBPaper00048837 WB:WBPerson18607 WB:WBPerson2987 Animals survive longer, or do not respond to the same degree as control animals under similar conditions of bisphenol A exposure. C_elegans_phenotype_ontology WBPhenotype:0002584 bisphenol A resistant Animals survive longer, or do not respond to the same degree as control animals under similar conditions of bisphenol A exposure. WB:WBPaper00024241 WB:WBPerson557 Pristionchus pacificus: Animals exhibit abnormal predatory behavior, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002585 predatory behavior abnormal Pristionchus pacificus: Animals exhibit abnormal predatory behavior, compared to controls. WB:WBPaper00053031 WB:WBPerson2987 WB:WBPerson38478 Pristionchus pacificus: Animals exhibit reduced predatory feeding behavior, indicated by reduced predation success, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002586 reduced predatory feeding behavior Pristionchus pacificus: Animals exhibit reduced predatory feeding behavior, indicated by reduced predation success, compared to controls. WB:WBPaper00053031 WB:WBPerson2987 WB:WBPerson38478 Animals are impaired in their burrowing ability compared to control animals in a Pluronic gel-based burrowing assay. C_elegans_phenotype_ontology WBPhenotype:0002587 Pluronic gel burrowing impaired Animals are impaired in their burrowing ability compared to control animals in a Pluronic gel-based burrowing assay. WB:WBPaper00058750 WB:WBPerson2987 WB:WBPerson43910 Animals exhibit variations or abnormalities in the structure, integrity, function, or quality of basement membranes, compared to controls. basement membrane abnormal C_elegans_phenotype_ontology WBPhenotype:0002588 basement membrane phenotype Animals exhibit variations or abnormalities in the structure, integrity, function, or quality of basement membranes, compared to controls. WB:WBPaper00037647 Animals exhibit a reduction in neuron degeneration, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002589 neuron degeneration reduced Animals exhibit a reduction in neuron degeneration, compared to control animals. WB:WBPerson2987 WB:WBPerson58 The linker cell of male animals becomes detached from the rest of the male gonad. C_elegans_phenotype_ontology WBPhenotype:0002590 linker cell detached The linker cell of male animals becomes detached from the rest of the male gonad. WB:WBPaper00046064 WB:WBPerson2987 One or more neurons of the animal exhibit one or more dendrites with reduced length compared to the corresponding dendrites in control animals. C_elegans_phenotype_ontology WBPhenotype:0002591 dendrite length reduced One or more neurons of the animal exhibit one or more dendrites with reduced length compared to the corresponding dendrites in control animals. WB:WBPaper00033050 WB:WBPerson2987 Animals exhibit variations in their response to changes in gravitational force, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002592 organism response to gravitational force abnormal Animals exhibit variations in their response to changes in gravitational force, compared to control animals. WB:WBPaper00030928 WB:WBPerson2987 Any variation in the decrease in a behavioral response to a repeated plate tap stimulus compared to control, over the short term. Short-term memory is memory that lasts for minutes to hours after the learning (training) event(s). C_elegans_phenotype_ontology WBPhenotype:0002593 short term plate tap habituation variant Any variation in the decrease in a behavioral response to a repeated plate tap stimulus compared to control, over the short term. Short-term memory is memory that lasts for minutes to hours after the learning (training) event(s). WB:WBPaper00006159 WB:WBPerson2987 Any variation in the decrease in a behavioral response to a repeated plate tap stimulus compared to control, over the long term. Long-term memory is memory that lasts for hours to days after the learning (training) event(s). C_elegans_phenotype_ontology WBPhenotype:0002594 long term plate tap habituation variant Any variation in the decrease in a behavioral response to a repeated plate tap stimulus compared to control, over the long term. Long-term memory is memory that lasts for hours to days after the learning (training) event(s). WB:WBPaper00006159 WB:WBPerson2987 The reduction in brood size caused by sleep deprivation is enhanced, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002595 sleep deprivation-induced brood size reduction enhanced The reduction in brood size caused by sleep deprivation is enhanced, compared to controls. WB:WBPaper00052970 WB:WBPerson2987 The reduction in brood size caused by sleep deprivation is suppressed, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002596 sleep deprivation-induced brood size reduction suppressed The reduction in brood size caused by sleep deprivation is suppressed, compared to controls. WB:WBPaper00052970 WB:WBPerson2987 Variations in the behavioral plasticity induced by the integration of two sensory signals (one of which is gustation (taste)) compared to control. For example, C. elegans animals can be trained to associate the taste of a substance (e.g. sodium chloride, normally an attractant) to an aversive stimuli (e.g. starvation) so that trained worms will avoid the substance in the absence of the aversive stimuli. Animals with this phenotype have an abnormal response to the trained stimuli compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002597 gustatory learning abnormal Variations in the behavioral plasticity induced by the integration of two sensory signals (one of which is gustation (taste)) compared to control. For example, C. elegans animals can be trained to associate the taste of a substance (e.g. sodium chloride, normally an attractant) to an aversive stimuli (e.g. starvation) so that trained worms will avoid the substance in the absence of the aversive stimuli. Animals with this phenotype have an abnormal response to the trained stimuli compared to controls. WB:WBPaper00059641 WB:WBPerson2987 Variations in the aversion of animals to substances sensed by gustation (taste) previously associated with an aversive stimuli during a gustation training protocol, compared to control. For example, C. elegans animals can be trained to associate the taste of a substance (e.g. sodium chloride, normally an attractant) to an aversive stimuli (e.g. starvation) so that trained worms will avoid the substance in the absence of the aversive stimuli. Animals with this phenotype will not exhibit the same aversion to the substance as compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002598 gustatory aversive learning abnormal Variations in the aversion of animals to substances sensed by gustation (taste) previously associated with an aversive stimuli during a gustation training protocol, compared to control. For example, C. elegans animals can be trained to associate the taste of a substance (e.g. sodium chloride, normally an attractant) to an aversive stimuli (e.g. starvation) so that trained worms will avoid the substance in the absence of the aversive stimuli. Animals with this phenotype will not exhibit the same aversion to the substance as compared to control animals. WB:WBPaper00059641 WB:WBPerson2987 Any variation in the decrease in a behavioral response to a repeated stimulus compared to control, over the long term. Long-term memory is memory that lasts for hours to days after the learning (training) event(s). long-term habituation abnormal long-term habituation variant C_elegans_phenotype_ontology WBPhenotype:0002599 long-term habituation phenotype Any variation in the decrease in a behavioral response to a repeated stimulus compared to control, over the long term. Long-term memory is memory that lasts for hours to days after the learning (training) event(s). WB:WBPaper00041586 WB:WBPerson2987 Any variation in the decrease in a behavioral response to a repeated stimulus compared to control, over the short term. Short-term memory is memory that lasts for minutes to hours after the learning (training) event(s). short-term habituation abnormal short-term habituation variant C_elegans_phenotype_ontology WBPhenotype:0002600 short-term habituation phenotype Any variation in the decrease in a behavioral response to a repeated stimulus compared to control, over the short term. Short-term memory is memory that lasts for minutes to hours after the learning (training) event(s). WB:WBPaper00041586 WB:WBPerson2987 Animals exhibit variations in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms over the short term, compared to controls. Short-term memory is memory that lasts for minutes to hours after the learning (training) event(s). short-term associative memory abnormal short-term associative memory variant C_elegans_phenotype_ontology WBPhenotype:0002601 short-term associative memory phenotype Animals exhibit variations in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms over the short term, compared to controls. Short-term memory is memory that lasts for minutes to hours after the learning (training) event(s). WB:WBPaper00041586 WB:WBPerson2987 Animals exhibit a decrease in the rate at which spontaneous backward locomotion is initiated compared to control. C_elegans_phenotype_ontology WBPhenotype:0002602 reduced frequency of spontaneous reversal initiation Animals exhibit a decrease in the rate at which spontaneous backward locomotion is initiated compared to control. WB:WBPaper00049647 WB:WBPerson2987 Animals exhibit an abnormal response to toxic proteins, either via exposure in the environment or expressed within the organism, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002603 protein toxicity response abnormal Animals exhibit an abnormal response to toxic proteins, either via exposure in the environment or expressed within the organism, compared to controls. WB:WBPaper00059748 WB:WBPerson2987 Animals exhibit an abnormal response to toxic dipeptide repeat proteins, either via exposure in the environment or expressed within the organism, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002604 dipeptide repeat protein toxicity abnormal Animals exhibit an abnormal response to toxic dipeptide repeat proteins, either via exposure in the environment or expressed within the organism, compared to controls. WB:WBPaper00059748 WB:WBPerson2987 Normally toxic dipeptide repeat proteins appear to be less toxic to animals, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002605 dipeptide repeat protein toxicity suppressed Normally toxic dipeptide repeat proteins appear to be less toxic to animals, compared to control animals. WB:WBPaper00059748 WB:WBPerson2987 Animals exhibit reduced necrotic cell death, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002606 necrotic cell death decreased Animals exhibit reduced necrotic cell death, compared to controls. WB:WBPaper00028466 WB:WBPaper00059770 WB:WBPerson2987 One or more cellular nuclei exhibit an abnormal size, compared to controls. nuclear size phenotype nuclear size variant C_elegans_phenotype_ontology WBPhenotype:0002607 nuclear size abnormal One or more cellular nuclei exhibit an abnormal size, compared to controls. WB:WBPaper00042522 WB:WBPerson2987 A body elongation defect in which embryos develop abnormally bulged dorsal surfaces. Hmp C_elegans_phenotype_ontology WBPhenotype:0002608 "After standard ethylmethane sulfonate mutagenesis, we screened directly for mutant embryos that are defective in body elongation. We isolated 13 recessive, zygotic-lethal mutants that, in addition to failing to elongate properly, show abnormally bulged dorsal surfaces (Fig. 1B). We call this novel phenotype Hmp (humpback); this phenotype contrasts with previously described elongation-defective Pat mutants that display bulges at variable positions (Williams and Waterston, 1994)." humpback A body elongation defect in which embryos develop abnormally bulged dorsal surfaces. WB:WBPaper00003046 "After standard ethylmethane sulfonate mutagenesis, we screened directly for mutant embryos that are defective in body elongation. We isolated 13 recessive, zygotic-lethal mutants that, in addition to failing to elongate properly, show abnormally bulged dorsal surfaces (Fig. 1B). We call this novel phenotype Hmp (humpback); this phenotype contrasts with previously described elongation-defective Pat mutants that display bulges at variable positions (Williams and Waterston, 1994)." WB:WBPaper00003046 An anterior enclosure defect in which the anterior portion of the embryo, unenclosed by the hypodermis, bulges to form a hammerhead shape. Hmr C_elegans_phenotype_ontology "However, in the remaining hmr-1 mutants the hypodermis fails to fully enclose the embryo. We call this phenotype Hmr (hammerhead; see Fig. 1F)." hammerhead An anterior enclosure defect in which the anterior portion of the embryo, unenclosed by the hypodermis, bulges to form a hammerhead shape. WB:WBPaper00003046 WB:WBPerson2987 Hmr WB:WBPaper00003046 "However, in the remaining hmr-1 mutants the hypodermis fails to fully enclose the embryo. We call this phenotype Hmr (hammerhead; see Fig. 1F)." WB:WBPaper00003046 Apoptosis occurs in cells or cell types that do not undergo apoptosis in controls. C_elegans_phenotype_ontology WBPhenotype:0002610 ectopic apoptosis Apoptosis occurs in cells or cell types that do not undergo apoptosis in controls. WB:WBPaper00044285 WB:WBPerson2987 The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell undergoing meiosis is impaired. C_elegans_phenotype_ontology WBPhenotype:0002611 meiotic cytoplasmic streaming defective The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell undergoing meiosis is impaired. WB:WBPaper00050908 WB:WBPerson2987 WB:WBPerson3569 The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell is abnormal compared to control. cytoplasmic streaming abnormal cytoplasmic streaming variant C_elegans_phenotype_ontology WBPhenotype:0002612 cytoplasmic streaming phenotype The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell is abnormal compared to control. GO:0099636 WB:WBPaper00050908 WB:WBPerson2987 WB:WBPerson3569 The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell undergoing meiosis is abnormal compared to control. meiotic cytoplasmic streaming abnormal meiotic cytoplasmic streaming variant C_elegans_phenotype_ontology WBPhenotype:0002613 meiotic cytoplasmic streaming phenotype The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell undergoing meiosis is abnormal compared to control. WB:WBPaper00050908 WB:WBPerson2987 WB:WBPerson3569 Genes normally silenced within heterochromatin are abnoramally de-repressed and exhibit expression, unlike controls. C_elegans_phenotype_ontology WBPhenotype:0002614 derepression of heterchromatic gene silencing Genes normally silenced within heterochromatin are abnoramally de-repressed and exhibit expression, unlike controls. WB:WBPaper00059527 WB:WBPerson2439 WB:WBPerson2987 Animals accumulate vacuoles in an abnormal manner in cells, tissues, and/or organs of the animal. C_elegans_phenotype_ontology WBPhenotype:0002615 abnormal accumulation of vacuoles Animals accumulate vacuoles in an abnormal manner in cells, tissues, and/or organs of the animal. WB:WBPaper00041673 WB:WBPerson2987 Cells exhibit an abnormal intracellular level (amount) of calcium, compared to controls. cellular calcium level phenotype cellular calcium level variant C_elegans_phenotype_ontology WBPhenotype:0002616 cellular calcium level abnormal Cells exhibit an abnormal intracellular level (amount) of calcium, compared to controls. WB:WBPaper00041673 WB:WBPerson2987 Cells exhibit a higher level of calcium in the cytosol, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002617 cytosolic calcium levels increased Cells exhibit a higher level of calcium in the cytosol, compared to controls. WB:WBPaper00041673 WB:WBPerson2987 Cells exhibit a lower level of calcium in the cytosol, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002618 cytosolic calcium levels decreased Cells exhibit a lower level of calcium in the cytosol, compared to controls. WB:WBPaper00041673 WB:WBPerson2987 Animals exhibit increased occurrence of cell death, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002619 cell death increased Animals exhibit increased occurrence of cell death, compared to controls. WB:WBPaper00041673 WB:WBPerson2987 Animals exhibit decreased occurrence of cell death, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002620 cell death decreased Animals exhibit decreased occurrence of cell death, compared to controls. WB:WBPaper00041673 WB:WBPerson2987 Animals exhibit a decrease in the expression of one or more known, endogenous, antimicrobial genes, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002621 antimicrobial gene expression reduced Animals exhibit a decrease in the expression of one or more known, endogenous, antimicrobial genes, compared to controls. WB:WBPaper00053771 WB:WBPerson2987 Animals exhibit decreased recruitment of actin to a site of injury, compared to controls. decreased recruitment of actin upon injury C_elegans_phenotype_ontology WBPhenotype:0002622 decreased recruitment of actin upon wounding Animals exhibit decreased recruitment of actin to a site of injury, compared to controls. WB:WBPaper00059214 WB:WBPerson2987 WB:WBPerson499 Animals exhibit no induction of expression of an antimicrobial peptide after an injury, unlike control animals. no induction of antimicrobial peptide expression after wounding C_elegans_phenotype_ontology WBPhenotype:0002623 no induction of antimicrobial peptide expression after injury Animals exhibit no induction of expression of an antimicrobial peptide after an injury, unlike control animals. WB:WBPaper00059214 WB:WBPerson2987 WB:WBPerson499 Cells display reduced incorporation of the thymidine analogue 5-Ethynyl-2'-deoxyuridine (EdU), suggesting reduced cell proliferation. Incorporation of EdU is an indication of active DNA synthesis and thus an indication of cells proceeding through the cell cycle. C_elegans_phenotype_ontology WBPhenotype:0002624 EdU incorporation reduced Cells display reduced incorporation of the thymidine analogue 5-Ethynyl-2'-deoxyuridine (EdU), suggesting reduced cell proliferation. Incorporation of EdU is an indication of active DNA synthesis and thus an indication of cells proceeding through the cell cycle. PMID:32973031 WB:WBPerson2987 WB:WBPerson36183 Animals exhibit visible, structural degeneration of the head, unlike control animals. C_elegans_phenotype_ontology WBPhenotype:0002625 head degeneration Animals exhibit visible, structural degeneration of the head, unlike control animals. WB:WBPerson2987 WB:WBPerson36183 PMID:32973031 Animals exhibit an abnormal attachment (or lack thereof) to a substrate, compared to controls. For some parasitic worms, attachment to host tissue surfaces, like endothelium, is a necessary behavior for their life cycle. C_elegans_phenotype_ontology WBPhenotype:0002626 attachment to substrate abnormal Animals exhibit an abnormal attachment (or lack thereof) to a substrate, compared to controls. For some parasitic worms, attachment to host tissue surfaces, like endothelium, is a necessary behavior for their life cycle. PMID:32973031 WB:WBPerson2987 WB:WBPerson36183 Animals exhibit an abnormal attachment (or lack thereof) to a substrate in vitro, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002627 in vitro attachment to substrate abnormal Animals exhibit an abnormal attachment (or lack thereof) to a substrate in vitro, compared to controls. PMID:32973031 WB:WBPerson2987 WB:WBPerson36183 Animals exhibit a reduced attachment to a substrate in vitro, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002628 in vitro attachment to substrate reduced Animals exhibit a reduced attachment to a substrate in vitro, compared to controls. PMID:32973031 WB:WBPerson2987 WB:WBPerson36183 Animals exhibit edema (swelling) of the intestine, compared to control animals. This swelling is distinct from distension of the intestinal lumen (swollen intestinal lumen). intestinal oedema swollen intestine C_elegans_phenotype_ontology WBPhenotype:0002629 intestinal edema Animals exhibit edema (swelling) of the intestine, compared to control animals. This swelling is distinct from distension of the intestinal lumen (swollen intestinal lumen). PMID:32973031 WB:WBPerson2987 WB:WBPerson36183 Animals exhibit degeneration of the epithelial system (skin, integument or tegument), compared to control animals. integument degeneration tegument degeneration C_elegans_phenotype_ontology WBPhenotype:0002630 epithelial system degeneration Animals exhibit degeneration of the epithelial system (skin, integument or tegument), compared to control animals. PMID:32973031 WB:WBPerson2987 WB:WBPerson36183 Animals exhibit edema (swelling) of one or more tissues, compared to control animals. tissue oedema tissue swelling C_elegans_phenotype_ontology WBPhenotype:0002631 tissue edema Animals exhibit edema (swelling) of one or more tissues, compared to control animals. PMID:32973031 WB:WBPerson2987 WB:WBPerson36183 Animals exhibit cells with an abnormal degree of chromatin accessibility, compared to controls, detected using techniques such as ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing). chromatin accessibility phenotype chromatin accessibility variant C_elegans_phenotype_ontology WBPhenotype:0002632 chromatin accessibility abnormal Animals exhibit cells with an abnormal degree of chromatin accessibility, compared to controls, detected using techniques such as ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing). WB:WBPaper00061371 WB:WBPerson2987 WB:WBPerson712 Animals exhibit a pharynx that recedes into the animal's interior such that the animal cannot feed. Pin C_elegans_phenotype_ontology WBPhenotype:0002633 pharynx ingressed Animals exhibit a pharynx that recedes into the animal's interior such that the animal cannot feed. WB:WBPaper00055692 WB:WBPerson2987 WB:WBPerson43879 Animals exhibit a resistance to endoplasmic reticulum (ER) stressors such as an accumulation of unfolded proteins or the presence of chemicals that induce ER stress, such as dithiothreitol (DDT) or tunicamycin, compared to controls. This may mean that animals fare better than controls in terms of survival or some metric of health when exposed to an inducer of ER stress. C_elegans_phenotype_ontology WBPhenotype:0002634 ER stress resistant Animals exhibit a resistance to endoplasmic reticulum (ER) stressors such as an accumulation of unfolded proteins or the presence of chemicals that induce ER stress, such as dithiothreitol (DDT) or tunicamycin, compared to controls. This may mean that animals fare better than controls in terms of survival or some metric of health when exposed to an inducer of ER stress. WB:WBPaper00050013 WB:WBPerson2987 Animals shed fragments of epidermis into the surrounding environment, unlike controls. In embryos, these fragments can be seen in the extra-embryonic space. C_elegans_phenotype_ontology WBPhenotype:0002635 epidermal shedding Animals shed fragments of epidermis into the surrounding environment, unlike controls. In embryos, these fragments can be seen in the extra-embryonic space. WB:WBPaper00052963 WB:WBPerson2987 One or more cells of the animal exhibit chromatin that has become detached from the nuclear periphery, unlike controls. C_elegans_phenotype_ontology WBPhenotype:0002636 detachment of chromatin from nuclear periphery One or more cells of the animal exhibit chromatin that has become detached from the nuclear periphery, unlike controls. WB:WBPaper00048885 WB:WBPerson14737 WB:WBPerson2987 Animals (or cells of the animal) exhibit reduced levels of iron in the body (or cells) compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002637 iron levels decreased Animals (or cells of the animal) exhibit reduced levels of iron in the body (or cells) compared to controls. WB:WBPaper00055104 WB:WBPerson2987 WB:WBPerson35689 Animals are more prone to infection, sickness and/or death caused by oomycete pathogens compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0002638 increased susceptibility to oomycete infection Animals are more prone to infection, sickness and/or death caused by oomycete pathogens compared to control animals. WB:WBPaper00060871 WB:WBPerson2987 WB:WBPerson53483 Animals exhibit specific or general variations in the composition of the microbiome at a body site compared to controls. microbiome composition variant C_elegans_phenotype_ontology WBPhenotype:0002639 microbiome composition abnormal Animals exhibit specific or general variations in the composition of the microbiome at a body site compared to controls. WB:WBPerson10314 WB:WBPerson2987 The physical strength or integrity of the cuticle is decreased compared to that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0002640 cuticle integrity decreased The physical strength or integrity of the cuticle is decreased compared to that observed for control animals. WB:WBPaper00061220 WB:WBPerson2987 The cuticle of animals becomes more permeable to dyes or stains, such as Hoechst 33258, or other substances compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002641 cuticle permeability increased The cuticle of animals becomes more permeable to dyes or stains, such as Hoechst 33258, or other substances compared to controls. WB:WBPaper00061220 WB:WBPerson2987 WB:WBPerson3900 Animals exposed to an exogenous chemical exhibit an abnormal accumulation of this chemical in the body of the animals, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002642 chemical accumulation abnormal Animals exposed to an exogenous chemical exhibit an abnormal accumulation of this chemical in the body of the animals, compared to controls. WB:WBPaper00061220 WB:WBPerson2987 WB:WBPerson3900 Animals exposed to an exogenous chemical exhibit an abnormal increase in accumulation of this chemical in the body of the animals, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002643 chemical accumulation increased Animals exposed to an exogenous chemical exhibit an abnormal increase in accumulation of this chemical in the body of the animals, compared to controls. WB:WBPaper00061220 WB:WBPerson2987 WB:WBPerson3900 Animals do not respond to the edge or gap in the medium surface they were supported on in the same manner as controls. In Mitchell et al., the precipice response was defined to be that within 2 seconds of the nose moving off the edge of the agar chunk, the worm begins a reversal that completes at least one full sine wave. precipice response abnormal C_elegans_phenotype_ontology WBPhenotype:0002644 precipice response variant Animals do not respond to the edge or gap in the medium surface they were supported on in the same manner as controls. In Mitchell et al., the precipice response was defined to be that within 2 seconds of the nose moving off the edge of the agar chunk, the worm begins a reversal that completes at least one full sine wave. WB:WBPaper00061677 WB:WBPerson2987 WB:WBPerson712 Animals exhibit an abnormal recovery from heat stress, compared to controls. heat stress recovery abnormal C_elegans_phenotype_ontology WBPhenotype:0002645 Exposure of wild type worms to a 6 h heat shock at 33°C led to a 20% decrease in worms with normal movement after a 48 h recovery at 20°C. thermorecovery abnormal Animals exhibit an abnormal recovery from heat stress, compared to controls. WB:WBPaper00060029 WB:WBPerson14884 WB:WBPerson2987 Exposure of wild type worms to a 6 h heat shock at 33°C led to a 20% decrease in worms with normal movement after a 48 h recovery at 20°C. WB:WBPaper00060029 Animals exhibit reduced recovery from heat stress compared to controls. Reduced recovery may be indicated, for example, by a decrease in normal movement, such as uncoordinated or jerky movement or paralysis, compared to controls. heat stress recovery reduced C_elegans_phenotype_ontology WBPhenotype:0002646 thermorecovery reduced Animals exhibit reduced recovery from heat stress compared to controls. Reduced recovery may be indicated, for example, by a decrease in normal movement, such as uncoordinated or jerky movement or paralysis, compared to controls. WB:WBPaper00060029 WB:WBPerson14884 WB:WBPerson2987 Animals display variations in the structure, organization of components, or spatial pattern of the neuronal extensions that carry afferent (incoming) action potentials towards the cell body, compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002647 dendrite morphology variant Animals display variations in the structure, organization of components, or spatial pattern of the neuronal extensions that carry afferent (incoming) action potentials towards the cell body, compared to that observed in control animals. WB:WBPaper00043988 WB:WBPerson2987 WB:WBPerson557 Animals display variations in the number or pattern of neuronal extensions that carry afferent (incoming) action potentials towards the cell body, compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0002648 dendrite branching variant Animals display variations in the number or pattern of neuronal extensions that carry afferent (incoming) action potentials towards the cell body, compared to that observed in control animals. WB:WBPaper00043988 WB:WBPerson2987 WB:WBPerson557 Characteristic response to chemicals with respect to egg-laying behavior varies compared to control. C_elegans_phenotype_ontology WBPhenotype:0002649 egg laying response to chemical abnormal Characteristic response to chemicals with respect to egg-laying behavior varies compared to control. WB:WBPaper00060230 WB:WBPerson2987 WB:WBPerson712 Characteristic response to extracted lipopolysaccharide from pathogens with respect to egg-laying behavior varies compared to control conditions. C_elegans_phenotype_ontology WBPhenotype:0002650 egg laying response to pathogen lipopolysaccharide variant Characteristic response to extracted lipopolysaccharide from pathogens with respect to egg-laying behavior varies compared to control conditions. WB:WBPaper00060230 WB:WBPerson2987 WB:WBPerson712 Cells exhibit an abnormal production of exophers, large (approximately four microns in diameter) membrane-bound extracellular vesicles that are released by budding out of cells into the extracellular space, compared to controls. exopher production abnormal exopher-genesis abnormal exopher-genesis phenotype C_elegans_phenotype_ontology WBPhenotype:0002651 exopher production phenotype Cells exhibit an abnormal production of exophers, large (approximately four microns in diameter) membrane-bound extracellular vesicles that are released by budding out of cells into the extracellular space, compared to controls. WB:WBPaper00061698 WB:WBPerson23531 WB:WBPerson2987 Cells exhibit a increase in production of exophers compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002652 exopher production increased Cells exhibit a increase in production of exophers compared to controls. WB:WBPaper00061698 WB:WBPerson23531 WB:WBPerson2987 Cells exhibit a decrease in production of exophers compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002653 exopher production decreased Cells exhibit a decrease in production of exophers compared to controls. WB:WBPaper00061698 WB:WBPerson23531 WB:WBPerson2987 Muscle cells exhibit an abnormal production of exophers compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002654 exopher production in muscle phenotype Muscle cells exhibit an abnormal production of exophers compared to controls. WB:WBPaper00061698 WB:WBPerson23531 WB:WBPerson2987 Muscle cells exhibit a decrease in production of exophers compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002655 exopher production in muscle decreased Muscle cells exhibit a decrease in production of exophers compared to controls. WB:WBPaper00061698 WB:WBPerson23531 WB:WBPerson2987 Muscle cells exhibit an increase in production of exophers compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002656 exopher production in muscle increased Muscle cells exhibit an increase in production of exophers compared to controls. WB:WBPaper00061698 WB:WBPerson23531 WB:WBPerson2987 Animals exhibit intolerance (e.g. lethality or significant growth defect) when exposed to saturated fatty acids via the diet, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002657 dietary saturated fatty acid intolerant Animals exhibit intolerance (e.g. lethality or significant growth defect) when exposed to saturated fatty acids via the diet, compared to controls. WB:WBPaper00060877 WB:WBPerson2987 WB:WBPerson488 Animals exhibit variations in muscle strength, as measured by a strength determining assay, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002658 muscle strength phenotype Animals exhibit variations in muscle strength, as measured by a strength determining assay, compared to controls. WB:WBPaper00061159 WB:WBPerson1754 WB:WBPerson2987 Animals exhibit a decrease in muscle strength, as measured by a strength determining assay, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002659 muscle strength decreased Animals exhibit a decrease in muscle strength, as measured by a strength determining assay, compared to controls. WB:WBPaper00061159 WB:WBPerson1754 WB:WBPerson2987 Animals exhibit a depletion of germline stem cells, compared to controls. C_elegans_phenotype_ontology WBPhenotype:0002660 germline stem cell depletion Animals exhibit a depletion of germline stem cells, compared to controls. WB:WBPaper00044909 WB:WBPerson2987 WB:WBPerson5747 Genes, whose expression is typically induced by an innate immune response, are actively expressed under conditions which would not normally induce an innate immune response gene expression program. C_elegans_phenotype_ontology WBPhenotype:0002661 constitutive expression of innate immune response genes Genes, whose expression is typically induced by an innate immune response, are actively expressed under conditions which would not normally induce an innate immune response gene expression program. WB:WBPaper00064532 WB:WBPerson2987 WB:WBPerson38719 Animals exhibit an increase in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002662 transgene silencing increased Animals exhibit an increase in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, compared to control. WB:WBPaper00064532 WB:WBPerson2987 WB:WBPerson38719 Cells of the animal exhibit variations in the intracellular lipid surveillance response, responsible for responding to and addressing lipid depletion inside of cells, compared to control. C_elegans_phenotype_ontology WBPhenotype:0002663 intracellular lipid surveillance response abnormal Cells of the animal exhibit variations in the intracellular lipid surveillance response, responsible for responding to and addressing lipid depletion inside of cells, compared to control. WB:WBPaper00064071 WB:WBPerson2987 WB:WBPerson58409 Any variation in the placement of RNA within in a cell or cellular compartment compared to control. RNA localization abnormal RNA subcellular localization abnormal C_elegans_phenotype_ontology WBPhenotype:0002664 RNA subcellular localization variant Any variation in the placement of RNA within in a cell or cellular compartment compared to control. WB:WBPerson2987 Any variation in the properties of an RNA condensate within a cell or cellular compartment compared to control. C_elegans_phenotype_ontology WBPhenotype:0002665 RNA condensate variant Any variation in the properties of an RNA condensate within a cell or cellular compartment compared to control. WB:WBPaper00065975 WB:WBPerson10419 WB:WBPerson2987 An abnormal dissolution of an RNA condensate within a cell or cellular compartment compared to control. C_elegans_phenotype_ontology WBPhenotype:0002666 abnormal dissolution of RNA condensate An abnormal dissolution of an RNA condensate within a cell or cellular compartment compared to control. WB:WBPaper00065975 WB:WBPerson10419 WB:WBPerson2987 Any variation in the specific actions or reactions of a hermaphrodite during mating compared to control. hermaphrodite mating abnormal C_elegans_phenotype_ontology WBPhenotype:0004001 hermaphrodite mating variant Any variation in the specific actions or reactions of a hermaphrodite during mating compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit defects in the production of the sensory signal to attract males. C_elegans_phenotype_ontology WBPhenotype:0004002 attraction signal defective Animals exhibit defects in the production of the sensory signal to attract males. WB:WBPaper00005109 WB:WBPerson557 Males exhibit defects in their response to the mate-finding cue. mate finding abnormal C_elegans_phenotype_ontology response to male attractant abnormal WBPhenotype:0004003 mate finding defective Males exhibit defects in their response to the mate-finding cue. WB:WBPaper00005109 WB:WBPerson557 The inability of a male to respond properly to a potential mate after contact. In C.elegans, proper response includes apposing the ventral side of his tail to the hermaphrodite's body and swimming backward. C_elegans_phenotype_ontology WBPhenotype:0004004 male response to contact defective The inability of a male to respond properly to a potential mate after contact. In C.elegans, proper response includes apposing the ventral side of his tail to the hermaphrodite's body and swimming backward. GO:0034606 WB:WBPaper00000392 WB:WBPaper00002109 WB:WBPerson557 Males exhibit variations in mating behavior prior to contacting its mate compared to control. pre hermaphrodite contact abnormal C_elegans_phenotype_ontology WBPhenotype:0004005 pre hermaphrodite contact variant Males exhibit variations in mating behavior prior to contacting its mate compared to control. WB:WBPerson557 Males exhibit variations in mating behavior after contacting its mate compared to control. post hermaphrodite contact abnormal C_elegans_phenotype_ontology WBPhenotype:0004006 post hermaphrodite contact variant Males exhibit variations in mating behavior after contacting its mate compared to control. WB:WBPerson557 Males exhibit defects in the continuous prodding of spicule tips at the vulva prior to prolonged spicule insertion. C_elegans_phenotype_ontology spicule prodding defective WBPhenotype:0004007 periodic spicule prodding defective Males exhibit defects in the continuous prodding of spicule tips at the vulva prior to prolonged spicule insertion. GO:0034609 WB:WBPerson2021 WB:WBPerson557 Males exhibit defects in the prolonged, tonic, spicule extrusion through the vulva prior to sperm transfer. C_elegans_phenotype_ontology prolonged spicule protraction defective WBPhenotype:0004008 sustained spicule protraction defective Males exhibit defects in the prolonged, tonic, spicule extrusion through the vulva prior to sperm transfer. GO:0034609 WB:WBPerson2021 WB:WBPerson557 Any variation in the mating process that includes the male stopping at the vulva (usually after backing) compared to control. In C. elegans general vulva location (stopping) requires the hook sensillum. approximate vulval location abnormal C_elegans_phenotype_ontology approximate vulva location variant general vulval location abnormal WBPhenotype:0004009 approximate vulval location variant Any variation in the mating process that includes the male stopping at the vulva (usually after backing) compared to control. In C. elegans general vulva location (stopping) requires the hook sensillum. WB:WBPaper00002109 WB:WBPerson2021 WB:WBPerson557 Any variation in the mating process that includes the male positioning his tail precisely over the vulva so that he may insert his spicules and ejaculate compared to control. In C. elegans precise vulva location (coordinating movement and tail positioning) requires the post cloacal sensillium and the spicules. precise vulval location abnormal C_elegans_phenotype_ontology precise vulva location variant WBPhenotype:0004010 precise vulval location variant Any variation in the mating process that includes the male positioning his tail precisely over the vulva so that he may insert his spicules and ejaculate compared to control. In C. elegans precise vulva location (coordinating movement and tail positioning) requires the post cloacal sensillium and the spicules. WB:WBPaper00002109 WB:WBPerson2021 WB:WBPerson557 Any variation in the retraction of spicules after all sperm that exit the seminal vesicle have been released compared to control. C_elegans_phenotype_ontology WBPhenotype:0004011 sperm transfer cessation defective Any variation in the retraction of spicules after all sperm that exit the seminal vesicle have been released compared to control. WB:WBPaper00028400 Any variation in the continued movement of sperm through the vas deferens, exiting the cloaca, compared to control. In C. elegans, when all sperm that exit the seminal vesicle have been released, the spicules retract into the male. C_elegans_phenotype_ontology WBPhenotype:0004012 sperm transfer continuation defective Any variation in the continued movement of sperm through the vas deferens, exiting the cloaca, compared to control. In C. elegans, when all sperm that exit the seminal vesicle have been released, the spicules retract into the male. WB:WBPaper00028400 Any variation in the initial movement of sperm through the vas deferens, exiting the cloaca, compared to control. C_elegans_phenotype_ontology WBPhenotype:0004013 sperm release defective Any variation in the initial movement of sperm through the vas deferens, exiting the cloaca, compared to control. WB:WBPaper00028400 Any variation in the specific actions or reactions of a hermaphrodite after male contact during mating compared to control. post male contact abnormal C_elegans_phenotype_ontology WBPhenotype:0004014 post male contact variant Any variation in the specific actions or reactions of a hermaphrodite after male contact during mating compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the specific actions or reactions of a hermaphrodite prior to male contact during mating compared to control. pre male contact abnormal C_elegans_phenotype_ontology WBPhenotype:0004015 pre male contact variant Any variation in the specific actions or reactions of a hermaphrodite prior to male contact during mating compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the behavior exhibited by dauer larva in which they crawl up upon the substrate and wave back and forth while standing on their tail compared to control. Nictation is often associated with the search for a new host. dauer nictation behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0004016 dauer nictation behavior variant Any variation in the behavior exhibited by dauer larva in which they crawl up upon the substrate and wave back and forth while standing on their tail compared to control. Nictation is often associated with the search for a new host. WB:WBPaper00027241 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in their ability to maintain characteristic and effective locomotion compared to control. locomotor coordination abnormal C_elegans_phenotype_ontology WBPhenotype:0004017 locomotor coordination variant Animals exhibit variations in their ability to maintain characteristic and effective locomotion compared to control. WB:WBperson557 Any variation in the propagation of the contraction sine wave along the body while an animal travels from one location to another, compared to control. sinusoidal movement abnormal C_elegans_phenotype_ontology WBPhenotype:0004018 sinusoidal movement variant Any variation in the propagation of the contraction sine wave along the body while an animal travels from one location to another, compared to control. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0004021 obsolete exaggerated body bends true Any variation in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control. amplitude of body bends variant amplitude of movement abnormal C_elegans_phenotype_ontology WBPhenotype:0004022 amplitude of sinusoidal movement variant Any variation in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the frequency of oscillations between adjacent body segments from that observed for control animals. WBPhenotype:0002329 frequency of sinusoidal movement variant temporal frequency of sinusoidal movement variant bending frequency abnormal frequency of body bend abnormal C_elegans_phenotype_ontology WBPhenotype:0004023 frequency of body bend variant Animals exhibit variations in the frequency of oscillations between adjacent body segments from that observed for control animals. WB:WBPaper00024949 WB:WBPerson557 WB:WBPerson712 Any variation in the distance in the line of advance of a body wave from any one point to the next point of corresponding phase compared to control. wavelength of movement abnormal C_elegans_phenotype_ontology WBPhenotype:0004024 wavelength of movement variant Any variation in the distance in the line of advance of a body wave from any one point to the next point of corresponding phase compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the net velocity of an animal, that is, the maximum distance an animal traverses over an extended period of time, from that observed for control animals. velocity of movement abnormal C_elegans_phenotype_ontology WBPhenotype:0004025 velocity of movement variant Animals exhibit variations in the net velocity of an animal, that is, the maximum distance an animal traverses over an extended period of time, from that observed for control animals. WB:WBPaper00032008 WB:WBPerson712 Variations in the ability of an animal to respond with characteristic backward movement after a nose-on collision with an object compared to control. In C. elegans, this phenotype is usually assayed via stroking with a hair or similar fiber on the anterior most tip of the animal. nose touch abnormal C_elegans_phenotype_ontology WBPhenotype:0004026 nose touch variant Variations in the ability of an animal to respond with characteristic backward movement after a nose-on collision with an object compared to control. In C. elegans, this phenotype is usually assayed via stroking with a hair or similar fiber on the anterior most tip of the animal. WB:WBPaper00001705 WB:WBPerson557 Animals exhibit variations in their response to substrate vibration compared to control. plate tap reflex abnormal C_elegans_phenotype_ontology WBPhenotype:0004027 plate tap reflex variant Animals exhibit variations in their response to substrate vibration compared to control. WB:WBPerson557 Animals exhibit variations in modulating their locomotory rate in response to its food , compared to control. Basal slowing response refers to when well-fed animals move more slowly in the presence of bacteria than in the absence of bacteria . Second , food-deprived control animals , when transferred to bacteria , display a dramatically enhanced slowing response that ensures that the animals do not leave their newly encountered source of food. slowing response on food abnormal C_elegans_phenotype_ontology WBPhenotype:0004028 slowing response on food variant Animals exhibit variations in modulating their locomotory rate in response to its food , compared to control. Basal slowing response refers to when well-fed animals move more slowly in the presence of bacteria than in the absence of bacteria . Second , food-deprived control animals , when transferred to bacteria , display a dramatically enhanced slowing response that ensures that the animals do not leave their newly encountered source of food. WB:WBPaper00004195 WB:WBPerson2021 Any variation with respect to perception or response to mechanical stimuli in a sex dependent manner compared to control animals. sexually dimorphic mechanosensation abnormal C_elegans_phenotype_ontology WBPhenotype:0004029 sexually dimorphic mechanosensation variant Any variation with respect to perception or response to mechanical stimuli in a sex dependent manner compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the response by the male to a hermaphrodite after initial contact following mate finding compared to control. In C. elegans the male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate. Rsp male response to hermaphrodite abnormal C_elegans_phenotype_ontology WBPhenotype:0004030 male response to hermaphrodite variant Any variation in the response by the male to a hermaphrodite after initial contact following mate finding compared to control. In C. elegans the male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate. GO:0034606 WB:WBPaper00002109 WB:WBPerson2021 WB:WBPerson557 Any variation in the ability of an animal to search for a mate compared to control. In C. elegans, this is defined by failure of the leaving assay. mate searching abnormal C_elegans_phenotype_ontology WBPhenotype:0004031 mate searching variant Any variation in the ability of an animal to search for a mate compared to control. In C. elegans, this is defined by failure of the leaving assay. WB:WBPaper00024428 The apparent partial collapse of the vulval invagination and the elongation of central vulva cells often leading to a flattened appearance. Sqv C_elegans_phenotype_ontology WBPhenotype:0006001 squashed vulva The apparent partial collapse of the vulval invagination and the elongation of central vulva cells often leading to a flattened appearance. WB:WBPaper00003405 Any variation in the processes that govern acquisition of particular cell fates in the embryo, from the time of zygote formation until hatching compared to control. embryonic cell fate specification abnormal C_elegans_phenotype_ontology WBPhenotype:0008001 embryonic cell fate specification variant Any variation in the processes that govern acquisition of particular cell fates in the embryo, from the time of zygote formation until hatching compared to control. WB:kmva Any variation in the processes that govern acquisition of somatic cell fates in the embryo, from the time of zygote formation until hatching compared to control. embryonic somatic cell fate specification abnormal C_elegans_phenotype_ontology WBPhenotype:0008002 embryonic somatic cell fate specification variant Any variation in the processes that govern acquisition of somatic cell fates in the embryo, from the time of zygote formation until hatching compared to control. WB:kmva Any variation in a learned olfactory response whereby exposure of animals to odorants during specific developmental times or physiological states results in a lasting memory compared to control. In control animals, this imprinting determines the animal's behavior upon encountering the same odorant at a later time. olfactory imprinting abnormal odorant imprinting abnormal C_elegans_phenotype_ontology WBPhenotype:0008003 odorant imprinting variant Any variation in a learned olfactory response whereby exposure of animals to odorants during specific developmental times or physiological states results in a lasting memory compared to control. In control animals, this imprinting determines the animal's behavior upon encountering the same odorant at a later time. WB:WBPaper00026662 WB:WBPerson1843 Variations in the process(es) by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter compared to control. cell growth abnormal C_elegans_phenotype_ontology WBPhenotype:0010001 cell growth variant Variations in the process(es) by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter compared to control. GO:0016049 WB:rk Variations in the process(es) involved in the assembly and arrangement of cell structures compared to control. cell organization biogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0010002 cell organization biogenesis variant Variations in the process(es) involved in the assembly and arrangement of cell structures compared to control. GO:0016043 WB:rk Animals exhibit a decreased rate programmed cell death pathway leading to the destruction of the cell, viewable in its terminally dismanteled form of a cell corpse, compared to that observed for control cells. C_elegans_phenotype_ontology WBPhenotype:0010003 cell corpse appearance delayed Animals exhibit a decreased rate programmed cell death pathway leading to the destruction of the cell, viewable in its terminally dismanteled form of a cell corpse, compared to that observed for control cells. WB:WBPerson712 WB:rk Variations in the process(es) that constitute cell corpse degradation within the engulfing cell compared to control. WB:rk cell corpse degradation abnormal C_elegans_phenotype_ontology WBPhenotype:0010004 cell corpse degradation variant Variations in the process(es) that constitute cell corpse degradation within the engulfing cell compared to control. WB:rk