Definition:
A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive.
Comment:
Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP.
class Information
The status of eosinophils as true professional antigen presenting cells is unclear, despite their ability to present exogenous peptides and peptides processed from exogenous proteins (in certain studies) via MHC Class II and activate T cells. Per the equivalence axioms, 'eosinophil' is reasoned to be a subclass of 'professional antigen presenting cell', though the role of eosinophils as such in the body may be limited.
class Relations
- (eosinophilandhas partbfosomeeosinophil peroxidaseprandhas partbfosomeerythroid transcription factorprandhas partbfosomeendothelial transcription factor GATA-2prandhas partbfosomenon-secretory ribonucleaseprandhas partbfosomeeosinophil cationic proteinprandhas partbfosomeeosinophil granule major basic proteinprandhas partbfosome(nucleusgoandhas characteristicrosomelobedpato)andhas plasma membrane partrosomeintegrin alpha-4prandcapable ofrosomeantigen processing and presentation of peptide antigen via MHC class IIgoandcapable ofrosomeleukotriene production involved in inflammatory responsegoandcapable ofrosomerespiratory burstgo)
- professional antigen presenting cell
- eosinophil
- has partbfosomeeosinophil peroxidasepr
- has partbfosomeerythroid transcription factorpr
- has partbfosomeendothelial transcription factor GATA-2pr
- has partbfosomenon-secretory ribonucleasepr
- has partbfosomeeosinophil cationic proteinpr
- has partbfosomeeosinophil granule major basic proteinpr
- has partbfosome(nucleusgoandhas characteristicrosomelobedpato)
- has plasma membrane partrosomeintegrin alpha-4pr
- develops fromrosomeband form eosinophil
- capable ofrosomeantigen processing and presentation of peptide antigen via MHC class IIgo
- capable ofrosomeleukotriene production involved in inflammatory responsego
- capable ofrosomerespiratory burstgo