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Protein Ontology report - noggin
PR:000000021 - http://purl.obolibrary.org/obo/PR_000000021
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000021   
  PRO namenoggin 
  Synonyms
PRO-Short-label: EXACT:NOG
  Definition"A protein that is a translation product of the human NOG gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 12                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF008129
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000021 noggin, NOG
Yes
organism-gene


PR:O93525 noggin (chicken), chick-NOG

organism-gene


PR:P97466 noggin (mouse), mNOG

organism-sequence


PR:P97466-1 noggin isoform 1 (mouse), mNOG/iso:1
Yes
organism-gene


PR:Q13253 noggin (human), hNOG

organism-sequence


PR:000000107 noggin sequence variant P35S (human), hNOG/var:P35S
Yes
organism-sequence


PR:000000108 noggin sequence variant P223L (human), hNOG/var:P223L
Yes
organism-sequence


PR:000000109 noggin sequence variant P35R (human), hNOG/var:P35R
Yes
organism-sequence


PR:000000110 noggin sequence variant C184Y (human), hNOG/var:C184Y
Yes
organism-sequence


PR:000000111 noggin sequence variant G189C (human), hNOG/var:G189C
Yes
organism-sequence


PR:000000112 noggin sequence variant R204L (human), hNOG/var:R204L
Yes
organism-sequence


PR:000000113 noggin sequence variant W217G (human), hNOG/var:W217G
Yes
organism-sequence


PR:000000114 noggin sequence variant I220N (human), hNOG/var:I220N
Yes
organism-sequence


PR:000000115 noggin sequence variant Y222C (human), hNOG/var:Y222C
Yes
organism-sequence


PR:000000116 noggin sequence variant Y222D (human), hNOG/var:Y222D
Yes
organism-sequence


PR:Q13253-1 noggin isoform 1 (human), hNOG/iso:1

organism-modification


PR:000036421 noggin isoform 1, signal peptide removed form (human), hNOG/iso:1/SigPep-
Yes
organism-modification


PR:000057007 noggin O-glycosylated 1 (human), hNOG/OGlyco:1

sequence


PR:000000106 noggin isoform 1, NOG/iso:1

organism-sequence


PR:P97466-1 noggin isoform 1 (mouse), mNOG/iso:1
Yes
organism-sequence


PR:Q13253-1 noggin isoform 1 (human), hNOG/iso:1

organism-modification


PR:000036421 noggin isoform 1, signal peptide removed form (human), hNOG/iso:1/SigPep-
Yes
modification


PR:000000457 noggin isoform 1, signal peptide removed form, NOG/iso:1/SigPep-

organism-modification


PR:000036421 noggin isoform 1, signal peptide removed form (human), hNOG/iso:1/SigPep-
Yes
modification


PR:000025434 noggin proteolytic cleavage product, NOG/ClvPrd

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000021 NOG

"A protein that is a translation product of the human NOG gene or a 1:1 ortholog thereof." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007275 multicellular organism development PANTHER:PTHR10494; PIRSF:PIRSF008129; UniProtKB:P97466; UniProtKB:Q13253
GO:0030509 BMP signaling pathway PANTHER:PTHR10494; PIRSF:PIRSF008129; UniProtKB:P97466; UniProtKB:Q13253
GO:0030514 negative regulation of BMP signaling pathway PANTHER:PTHR10494; PIRSF:PIRSF008129; UniProtKB:P97466; UniProtKB:Q13253
PR:000000107 hNOG/var:P35S
UniProtKB:Q13253, Pro-35, CHEBI:29999 | noggin sequence variant 1 (human)
"A noggin (human) that has a Ser residue at the position equivalent to Pro-35 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Pro-35, CHEBI:29999." [PMID:11857750, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050788 proximal symphalangism PMID:11857750
PR:000000108 hNOG/var:P223L
UniProtKB:Q13253, Pro-223, CHEBI:30006 | noggin sequence variant 10 (human)
"A noggin (human) that has a Leu residue at the position equivalent to Pro-223 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Pro-223, CHEBI:30006." [PMID:10080184, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050788 proximal symphalangism PMID:10080184
PR:000000109 hNOG/var:P35R
UniProtKB:Q13253, Pro-35, CHEBI:29952 | noggin sequence variant 2 (human)
"A noggin (human) that has an Arg residue at the position equivalent to Pro-35 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Pro-35, CHEBI:29952." [PMID:11545688, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050788 proximal symphalangism PMID:11545688
DO:0050789 tarsal-carpal coalition syndrome PMID:11545688
PR:000000110 hNOG/var:C184Y
UniProtKB:Q13253, Cys-184, CHEBI:46858 | noggin sequence variant 3 (human)
"A noggin (human) that has a Tyr residue at the position equivalent to Cys-184 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Cys-184, CHEBI:46858." [PMID:11846737, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050788 proximal symphalangism PMID:11846737
PR:000000111 hNOG/var:G189C
UniProtKB:Q13253, Gly-189, CHEBI:29950 | noggin sequence variant 4 (human)
"A noggin (human) that has a Cys residue at the position equivalent to Gly-189 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Gly-189, CHEBI:29950." [PMID:99178269, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050788 proximal symphalangism PMID:99178269
PR:000000112 hNOG/var:R204L
UniProtKB:Q13253, Arg-204, CHEBI:30006 | noggin sequence variant 5 (human)
"A noggin (human) that has a Leu residue at the position equivalent to Arg-204 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Arg-204, CHEBI:30006." [PMID:11545688, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050789 tarsal-carpal coalition syndrome PMID:11545688
PR:000000113 hNOG/var:W217G
UniProtKB:Q13253, Trp-217, CHEBI:29947 | noggin sequence variant 6 (human)
"A noggin (human) that has a Gly residue at the position equivalent to Trp-217 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Trp-217, CHEBI:29947." [PMID:10080184, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050788 proximal symphalangism PMID:10080184
PR:000000114 hNOG/var:I220N
UniProtKB:Q13253, Ile-220, CHEBI:50347 | noggin sequence variant 7 (human)
"A noggin (human) that has an Asn residue at the position equivalent to Ile-220 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Ile-220, CHEBI:50347." [PMID:10080184, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050788 proximal symphalangism PMID:10080184
PR:000000115 hNOG/var:Y222C
UniProtKB:Q13253, Tyr-222, CHEBI:29950 | noggin sequence variant 8 (human)
"A noggin (human) that has a Cys residue at the position equivalent to Tyr-222 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Tyr-222, CHEBI:29950." [PMID:10080184, PMID:11545688, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050788 proximal symphalangism PMID:11545688
DO:0050789 tarsal-carpal coalition syndrome PMID:10080184
PR:000000116 hNOG/var:Y222D
UniProtKB:Q13253, Tyr-222, CHEBI:29958 | noggin sequence variant 9 (human)
"A noggin (human) that has an Asp residue at the position equivalent to Tyr-222 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Tyr-222, CHEBI:29958." [PMID:10080184, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050788 proximal symphalangism PMID:10080184
PR:000036421 hNOG/iso:1/SigPep-
UniProtKB:Q13253-1, 28-232 | PRO_0000019813
"A noggin isoform 1, signal peptide removed form in human. UniProtKB:Q13253-1, 28-232." [PMID:11562478, PMID:12478285, PRO:CNA]		 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:12478285
enablesGO:0005515 protein binding with PR:000036517 hBMP7/iso:1/mature/NGlyco:1 PMID:12478285
located_inGO:0005615 extracellular space PMID:11562478
PR:P97466-1 mNOG/iso:1

"A noggin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:15110716