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Protein Ontology report - Rho-associated protein kinase
PR:000000024 - http://purl.obolibrary.org/obo/PR_000000024
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000024   
  PRO nameRho-associated protein kinase 
  Definition"A protein that is a translation product of an evolutionary-related gene with core domain composition consisting of an N-terminal Protein kinase domain (Pfam:PF00069), a Rho Binding domain (Pfam:PF08912), and a PH domain (Pfam:PF00169) and a Phorbol esters/diacylglycerol binding domain (C1 domain) (Pfam:PF00130) at the C-terminus. Rho-associated protein kinases are mediators of many cellular processes by being effectors of the small GTP-binding protein Rho." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 6                                        
         Sequence3                                                  Organism-Sequence 8                                        
         Modification11                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037568
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000024 Rho-associated protein kinase, NOG

Yes

gene



PR:000000120 Rho-associated protein kinase 1, ROCK1


organism-gene



PR:P70335 Rho-associated protein kinase 1 (mouse), mROCK1


organism-sequence



PR:P70335-1 Rho-associated protein kinase 1 isoform 1 (mouse), mROCK1/iso:1


organism-modification



PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse), mROCK1/iso:1/Clv:1

Yes

organism-sequence



PR:P70335-2 Rho-associated protein kinase 1 isoform m2 (mouse), mROCK1/iso:m2


organism-gene



PR:Q13464 Rho-associated protein kinase 1 (human), hROCK1


organism-sequence



PR:Q13464-1 Rho-associated protein kinase 1 isoform 1 (human), hROCK1/iso:1

Yes

organism-modification



PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human), hROCK1/iso:1/Clv:1

Yes

organism-modification



PR:000044586 Rho-associated protein kinase 1 isoform 1 unmodified form (human), hROCK1/iso:1/UnMod

Yes

organism-modification



PR:000061208 Rho-associated protein kinase 1, initiator methionine removed form (human), hROCK1/InitMet-


organism-modification



PR:000070060 Rho-associated protein kinase 1 deaminated 1 (human), hROCK1/Deam:1


organism-modification



PR:000070524 Rho-associated protein kinase 1 phosphorylated 1 (human), hROCK1/Phos:1


organism-modification



PR:000082399 Rho-associated protein kinase 1 deaminated 2 (human), hROCK1/Deam:2


organism-gene



PR:Q63644 Rho-associated protein kinase 1 (rat), rROCK1


organism-sequence



PR:Q63644-1 Rho-associated protein kinase 1 isoform r1 (rat), rROCK1/iso:r1


organism-sequence



PR:Q63644-2 Rho-associated protein kinase 1 isoform r2 (rat), rROCK1/iso:r2


sequence



PR:000000307 Rho-associated protein kinase 1 isoform 1, ROCK1/iso:1


organism-sequence



PR:P70335-1 Rho-associated protein kinase 1 isoform 1 (mouse), mROCK1/iso:1


organism-modification



PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse), mROCK1/iso:1/Clv:1

Yes

organism-sequence



PR:Q13464-1 Rho-associated protein kinase 1 isoform 1 (human), hROCK1/iso:1

Yes

organism-modification



PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human), hROCK1/iso:1/Clv:1

Yes

organism-modification



PR:000044586 Rho-associated protein kinase 1 isoform 1 unmodified form (human), hROCK1/iso:1/UnMod

Yes

modification



PR:000000563 Rho-associated protein kinase 1 isoform 1 cleaved 1, ROCK1/iso:1/Clv:1


organism-modification



PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human), hROCK1/iso:1/Clv:1

Yes

organism-modification



PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse), mROCK1/iso:1/Clv:1

Yes

modification



PR:000002529 Rho-associated protein kinase 1 isoform 1 unmodified form, ROCK1/iso:1/UnMod


organism-modification



PR:000044586 Rho-associated protein kinase 1 isoform 1 unmodified form (human), hROCK1/iso:1/UnMod

Yes

modification



PR:000026574 Rho-associated protein kinase 1 isoform 1, initiator methionine removed form, ROCK1/iso:1/InitMet-


modification



PR:000018280 Rho-associated protein kinase 1, initiator methionine removed form, ROCK1/InitMet-


modification



PR:000026574 Rho-associated protein kinase 1 isoform 1, initiator methionine removed form, ROCK1/iso:1/InitMet-


modification



PR:000025435 Rho-associated protein kinase 1 proteolytic cleavage product, ROCK1/ClvPrd


modification



PR:000000563 Rho-associated protein kinase 1 isoform 1 cleaved 1, ROCK1/iso:1/Clv:1


organism-modification



PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human), hROCK1/iso:1/Clv:1

Yes

organism-modification



PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse), mROCK1/iso:1/Clv:1

Yes

gene



PR:000000121 Rho-associated protein kinase 2, ROCK2


organism-gene



PR:O75116 Rho-associated protein kinase 2 (human), hROCK2


organism-sequence



PR:O75116-1 Rho-associated protein kinase 2 isoform 1 (human), hROCK2/iso:1

Yes

organism-modification



PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human), hROCK2/iso:1/Clv:1

Yes

organism-modification



PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human), hROCK2/iso:1/Phos:1

Yes

organism-modification



PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human), hROCK2/iso:1/Phos:2

Yes

organism-modification



PR:000066276 Rho-associated protein kinase 2 methylated 1 (human), hROCK2/Me:1


organism-modification



PR:000071951 Rho-associated protein kinase 2 methylated 2 (human), hROCK2/Me:2


organism-modification



PR:000074887 Rho-associated protein kinase 2 phosphorylated 1 (human), hROCK2/Phos:1


organism-gene



PR:P70336 Rho-associated protein kinase 2 (mouse), mROCK2


organism-sequence



PR:P70336-1 Rho-associated protein kinase 2 isoform 1 (mouse), mROCK2/iso:1


organism-sequence



PR:P70336-2 Rho-associated protein kinase 2 isoform 2 (mouse), mROCK2/iso:2

Yes

organism-gene



PR:Q62868 Rho-associated protein kinase 2 (rat), rROCK2


sequence



PR:000000308 Rho-associated protein kinase 2 isoform 1, ROCK2/iso:1


organism-sequence



PR:O75116-1 Rho-associated protein kinase 2 isoform 1 (human), hROCK2/iso:1

Yes

organism-modification



PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human), hROCK2/iso:1/Clv:1

Yes

organism-modification



PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human), hROCK2/iso:1/Phos:1

Yes

organism-modification



PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human), hROCK2/iso:1/Phos:2

Yes

organism-sequence



PR:P70336-1 Rho-associated protein kinase 2 isoform 1 (mouse), mROCK2/iso:1


modification



PR:000000462 Rho-associated protein kinase 2 isoform 1 phosphorylated form, ROCK2/iso:1/PhosRes+


modification



PR:000000565 Rho-associated protein kinase 2 isoform 1 phosphorylated 1, ROCK2/iso:1/Phos:1


organism-modification



PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human), hROCK2/iso:1/Phos:1

Yes

modification



PR:000000566 Rho-associated protein kinase 2 isoform 1 phosphorylated 2, ROCK2/iso:1/Phos:2


organism-modification



PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human), hROCK2/iso:1/Phos:2

Yes

modification



PR:000000564 Rho-associated protein kinase 2 isoform 1 cleaved 1, ROCK2/iso:1/Clv:1


organism-modification



PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human), hROCK2/iso:1/Clv:1

Yes

modification



PR:000002530 Rho-associated protein kinase 2 isoform 1 unmodified form, ROCK2/iso:1/UnMod


sequence



PR:000000309 Rho-associated protein kinase 2 isoform 2, ROCK2/iso:2


organism-sequence



PR:P70336-2 Rho-associated protein kinase 2 isoform 2 (mouse), mROCK2/iso:2

Yes

modification



PR:000025436 Rho-associated protein kinase 2 proteolytic cleavage product, ROCK2/ClvPrd


modification



PR:000000564 Rho-associated protein kinase 2 isoform 1 cleaved 1, ROCK2/iso:1/Clv:1


organism-modification



PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human), hROCK2/iso:1/Clv:1

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000024
NOG
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PANTHER:PTHR22988; PIRSF:PIRSF037568
GO:0007266 Rho protein signal transduction PANTHER:PTHR22988; PIRSF:PIRSF037568
enablesGO:0004672 protein kinase activity PANTHER:PTHR22988; PIRSF:PIRSF037568
GO:0004674 protein serine/threonine kinase activity PANTHER:PTHR22988; PIRSF:PIRSF037568
PR:000026340
hROCK1/iso:1/Clv:1
UniProtKB:Q13464-1, 1-1113
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:11283607
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000002529 ROCK1/iso:1/UnMod PMID:11283607
PR:000036476
mROCK1/iso:1/Clv:1
UniProtKB:P70335-1, 1-1113
acts_upstream_of_or_withinGO:0010659 cardiac muscle cell apoptotic process PMID:16983089
GO:0030036 actin cytoskeleton organization PMID:11283607; PMID:16983089
PR:000036477
hROCK2/iso:1/Clv:1
UniProtKB:O75116-1, 1-1131
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:15699075
GO:0030036 actin cytoskeleton organization PMID:15699075
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000002530 ROCK2/iso:1/UnMod PMID:15699075
located_inGO:0005622 intracellular anatomical structure PMID:15699075
PR:000036478
hROCK2/iso:1/Phos:1
UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:17446864
enablesGO:0004674 protein serine/threonine kinase activity PMID:17446864
located_inGO:0005634 nucleus PMID:15302935
PR:000036479
hROCK2/iso:1/Phos:2
UniProtKB:O75116-1, Thr-1078, MOD:00047
acts_upstream_of_or_withinGO:0042770 signal transduction in response to DNA damage PMID:17525332
PR:000044586
hROCK1/iso:1/UnMod
enablesGO:0004674 protein serine/threonine kinase activity PMID:15699075
GO:0004674 protein serine/threonine kinase activity PMID:15699075
PR:O75116-1
hROCK2/iso:1
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:9933571
GO:0051260 protein homooligomerization PMID:15291762
enablesGO:0004674 protein serine/threonine kinase activity PMID:9933571
GO:0031267 small GTPase binding PMID:11350930
located_inGO:0005622 intracellular anatomical structure PMID:16574662
PR:P70336-2
mROCK2/iso:2
rho-associated protein kinase 2 isoform ROCK2m (mouse)
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:17606625
GO:0051149 positive regulation of muscle cell differentiation PMID:17606625
enablesGO:0004674 protein serine/threonine kinase activity PMID:17606625
PR:Q13464-1
hROCK1/iso:1
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:10436159
GO:0007266 Rho protein signal transduction PMID:8798490
GO:0030036 actin cytoskeleton organization PMID:10436159
GO:0051260 protein homooligomerization PMID:15291762
enablesGO:0004674 protein serine/threonine kinase activity PMID:8798490
GO:0031267 small GTPase binding PMID:14660612; PMID:15475352