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Protein Ontology report - transcription factor Sp
PR:000000032 - http://purl.obolibrary.org/obo/PR_000000032
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000032   
  PRO nametranscription factor Sp 
  Definition"A protein that is a translation product of an evolutionary-related gene with core domain composition consisting of N-terminal serine/threonine stretches adjacent to one or two glutamine-rich domains, which constitute the activation domains, and three copies of the Zinc finger, C2H2 type (Pfam:PF00096) domain at the C-terminus that are involved in binding GC/GT-rich promoter elements." [PMID:16209919] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 11                                        
         Sequence1                                                  Organism-Sequence 18                                        
         Modification14                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037570
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000032 transcription factor Sp, fam:CBP-p300
Yes
gene


PR:000000133 transcription factor Sp1, SP1

organism-gene


PR:O89090 transcription factor Sp1 (mouse), mSP1

organism-sequence


PR:O89090-1 transcription factor Sp1 isoform 1 (mouse), mSP1/iso:1

organism-sequence


PR:O89090-2 transcription factor Sp1 isoform m2 (mouse), mSP1/iso:m2

organism-gene


PR:P08047 transcription factor Sp1 (human), hSP1

organism-sequence


PR:P08047-1 transcription factor Sp1 isoform 1 (human), hSP1/iso:1
Yes
organism-modification


PR:000028672 transcription factor Sp1 isoform 1 acetylated 2 (human), hSP1/iso:1/Ac:2

organism-modification


PR:000036496 transcription factor Sp1 isoform 1 acetylated 1 (human), hSP1/iso:1/Ac:1
Yes
organism-modification


PR:000036497 transcription factor Sp1 isoform 1 cleaved 1 (human), hSP1/iso:1/Clv:1
Yes
organism-modification


PR:000036498 transcription factor Sp1 isoform 1 O-glycosylated 1 (human), hSP1/iso:1/OGlyco:1
Yes
organism-modification


PR:000036499 transcription factor Sp1 isoform 1 phosphorylated 1 (human), hSP1/iso:1/Phos:1
Yes
organism-modification


PR:000036500 transcription factor Sp1 isoform 1 phosphorylated 2 (human), hSP1/iso:1/Phos:2
Yes
organism-modification


PR:000036501 transcription factor Sp1 isoform 1 phosphorylated 3 (human), hSP1/iso:1/Phos:3
Yes
organism-modification


PR:000036502 transcription factor Sp1 isoform 1 phosphorylated 4 (human), hSP1/iso:1/Phos:4
Yes
organism-modification


PR:000036503 transcription factor Sp1 isoform 1 sumoylated 1 (human), hSP1/iso:1/Sumo:1
Yes
organism-sequence


PR:P08047-2 transcription factor Sp1 isoform h2 (human), hSP1/iso:h2

organism-sequence


PR:P08047-3 transcription factor Sp1 isoform h3 (human), hSP1/iso:h3

organism-modification


PR:000045654 transcription factor Sp1 phosphorylated 1 (human), hSP1/Phos:1

organism-modification


PR:000049324 transcription factor Sp1, initiator methionine removed form (human), hSP1/InitMet-

organism-modification


PR:000069002 transcription factor Sp1 methylated 1 (human), hSP1/Me:1

organism-modification


PR:000073305 transcription factor Sp1 deaminated 1 (human), hSP1/Deam:1

organism-modification


PR:000080651 transcription factor Sp1 cysteinylated 1 (human), hSP1/Cyst:1

organism-gene


PR:Q01714 transcription factor Sp1 (rat), rSP1

organism-gene


PR:Q90WR9 transcription factor (chicken), chick-SP1

sequence


PR:000000380 transcription factor Sp1 isoform 1, SP1/iso:1

organism-sequence


PR:O89090-1 transcription factor Sp1 isoform 1 (mouse), mSP1/iso:1

organism-sequence


PR:P08047-1 transcription factor Sp1 isoform 1 (human), hSP1/iso:1
Yes
organism-modification


PR:000028672 transcription factor Sp1 isoform 1 acetylated 2 (human), hSP1/iso:1/Ac:2

organism-modification


PR:000036496 transcription factor Sp1 isoform 1 acetylated 1 (human), hSP1/iso:1/Ac:1
Yes
organism-modification


PR:000036497 transcription factor Sp1 isoform 1 cleaved 1 (human), hSP1/iso:1/Clv:1
Yes
organism-modification


PR:000036498 transcription factor Sp1 isoform 1 O-glycosylated 1 (human), hSP1/iso:1/OGlyco:1
Yes
organism-modification


PR:000036499 transcription factor Sp1 isoform 1 phosphorylated 1 (human), hSP1/iso:1/Phos:1
Yes
organism-modification


PR:000036500 transcription factor Sp1 isoform 1 phosphorylated 2 (human), hSP1/iso:1/Phos:2
Yes
organism-modification


PR:000036501 transcription factor Sp1 isoform 1 phosphorylated 3 (human), hSP1/iso:1/Phos:3
Yes
organism-modification


PR:000036502 transcription factor Sp1 isoform 1 phosphorylated 4 (human), hSP1/iso:1/Phos:4
Yes
organism-modification


PR:000036503 transcription factor Sp1 isoform 1 sumoylated 1 (human), hSP1/iso:1/Sumo:1
Yes
modification


PR:000000490 transcription factor Sp1 isoform 1 acetylated form, SP1/iso:1/AcRes+

modification


PR:000000596 transcription factor Sp1 isoform 1 acetylated 1, SP1/iso:1/Ac:1

organism-modification


PR:000036496 transcription factor Sp1 isoform 1 acetylated 1 (human), hSP1/iso:1/Ac:1
Yes
modification


PR:000028671 transcription factor Sp1 isoform 1 acetylated 2, SP1/iso:1/Ac:2

organism-modification


PR:000028672 transcription factor Sp1 isoform 1 acetylated 2 (human), hSP1/iso:1/Ac:2

modification


PR:000000492 transcription factor Sp1 isoform 1 glycosylated form, SP1/iso:1/GlycoRes+

modification


PR:000000598 transcription factor Sp1 isoform 1 O-glycosylated 1, SP1/iso:1/OGlyco:1

organism-modification


PR:000036498 transcription factor Sp1 isoform 1 O-glycosylated 1 (human), hSP1/iso:1/OGlyco:1
Yes
modification


PR:000000493 transcription factor Sp1 isoform 1 phosphorylated form, SP1/iso:1/PhosRes+

modification


PR:000000599 transcription factor Sp1 isoform 1 phosphorylated 1, SP1/iso:1/Phos:1

organism-modification


PR:000036499 transcription factor Sp1 isoform 1 phosphorylated 1 (human), hSP1/iso:1/Phos:1
Yes
modification


PR:000000600 transcription factor Sp1 isoform 1 phosphorylated 2, SP1/iso:1/Phos:2

organism-modification


PR:000036500 transcription factor Sp1 isoform 1 phosphorylated 2 (human), hSP1/iso:1/Phos:2
Yes
modification


PR:000000601 transcription factor Sp1 isoform 1 phosphorylated 3, SP1/iso:1/Phos:3

organism-modification


PR:000036501 transcription factor Sp1 isoform 1 phosphorylated 3 (human), hSP1/iso:1/Phos:3
Yes
modification


PR:000000602 transcription factor Sp1 isoform 1 phosphorylated 4, SP1/iso:1/Phos:4

organism-modification


PR:000036502 transcription factor Sp1 isoform 1 phosphorylated 4 (human), hSP1/iso:1/Phos:4
Yes
modification


PR:000000494 transcription factor Sp1 isoform 1 sumoylated form, SP1/iso:1/SumoLys+

modification


PR:000000603 transcription factor Sp1 isoform 1 sumoylated 1, SP1/iso:1/Sumo:1

organism-modification


PR:000036503 transcription factor Sp1 isoform 1 sumoylated 1 (human), hSP1/iso:1/Sumo:1
Yes
modification


PR:000000597 transcription factor Sp1 isoform 1 cleaved 1, SP1/iso:1/Clv:1

organism-modification


PR:000036497 transcription factor Sp1 isoform 1 cleaved 1 (human), hSP1/iso:1/Clv:1
Yes
modification


PR:000025441 transcription factor Sp1 proteolytic cleavage product, SP1/ClvPrd

modification


PR:000000597 transcription factor Sp1 isoform 1 cleaved 1, SP1/iso:1/Clv:1

organism-modification


PR:000036497 transcription factor Sp1 isoform 1 cleaved 1 (human), hSP1/iso:1/Clv:1
Yes
gene


PR:000015440 transcription factor Sp2, SP2

organism-gene


PR:Q02086 transcription factor Sp2 (human), hSP2

organism-sequence


PR:Q02086-1 transcription factor Sp2 isoform h1 (human), hSP2/iso:h1

organism-sequence


PR:Q02086-2 transcription factor Sp2 isoform h2 (human), hSP2/iso:h2

organism-gene


PR:Q9D2H6 transcription factor Sp2 (mouse), mSP2

organism-sequence


PR:Q9D2H6-1 transcription factor Sp2 isoform m1 (mouse), mSP2/iso:m1

organism-sequence


PR:Q9D2H6-2 transcription factor Sp2 isoform m2 (mouse), mSP2/iso:m2

gene


PR:000015441 transcription factor Sp3, SP3

organism-gene


PR:O70494 transcription factor Sp3 (mouse), mSP3

organism-sequence


PR:O70494-1 transcription factor Sp3 isoform m1 (mouse), mSP3/iso:m1

organism-sequence


PR:O70494-2 transcription factor Sp3 isoform m2 (mouse), mSP3/iso:m2

organism-sequence


PR:O70494-3 transcription factor Sp3 isoform m3 (mouse), mSP3/iso:m3

organism-gene


PR:Q02447 transcription factor Sp3 (human), hSP3

organism-sequence


PR:Q02447-1 transcription factor Sp3 isoform h1 (human), hSP3/iso:h1

organism-sequence


PR:Q02447-2 transcription factor Sp3 isoform h2 (human), hSP3/iso:h2

organism-sequence


PR:Q02447-3 transcription factor Sp3 isoform h3 (human), hSP3/iso:h3

organism-sequence


PR:Q02447-4 transcription factor Sp3 isoform h4 (human), hSP3/iso:h4

organism-sequence


PR:Q02447-5 transcription factor Sp3 isoform h5 (human), hSP3/iso:h5

organism-sequence


PR:Q02447-6 transcription factor Sp3 isoform h6 (human), hSP3/iso:h6

organism-modification


PR:000064827 transcription factor Sp3 sumoylated 1 (human), hSP3/Sumo:1

organism-modification


PR:000074925 transcription factor Sp3 methylated 1 (human), hSP3/Me:1

organism-gene


PR:Q90WR8 transcription factor Sp3 (chicken), chick-SP3

gene


PR:000015442 transcription factor Sp4, SP4

organism-gene


PR:Q02446 transcription factor Sp4 (human), hSP4

organism-modification


PR:000076073 transcription factor Sp4 deaminated 1 (human), hSP4/Deam:1

organism-gene


PR:Q62445 transcription factor Sp4 (mouse), mSP4

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000032 fam:CBP-p300

"A protein that is a translation product of an evolutionary-related gene with core domain composition consisting of N-terminal serine/threonine stretches adjacent to one or two glutamine-rich domains, which constitute the activation domains, and three copies of the Zinc finger, C2H2 type (Pfam:PF00096) domain at the C-terminus that are involved in binding GC/GT-rich promoter elements." [PMID:16209919]		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PIRSF:PIRSF037570
enablesGO:0003677 DNA binding PIRSF:PIRSF037570
GO:0003700 DNA-binding transcription factor activity PIRSF:PIRSF037570
PR:000036496 hSP1/iso:1/Ac:1

"A transcription factor Sp1 isoform 1 acetylated 1 in human." [PMID:15647279, PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:15647279
enablesGO:0003677 DNA binding PMID:15647279
located_inGO:0005634 nucleus PMID:15647279
PR:000036497 hSP1/iso:1/Clv:1
UniProtKB:P08047-1, 65-785
"A transcription factor Sp1 isoform 1 cleaved 1 in human. UniProtKB:P08047-1, 65-785." [PMID:16407261, PRO:CNA]		 enablesGO:0003700 DNA-binding transcription factor activity PMID:16407261
located_inGO:0005634 nucleus PMID:16407261
PR:000036498 hSP1/iso:1/OGlyco:1
UniProtKB:P08047-1, Ser-491, MOD:00805
"A transcription factor Sp1 isoform 1 O-glycosylated 1 in human. UniProtKB:P08047-1, Ser-491, MOD:00805." [PMID:11371615, PMID:9343410, PRO:CNA, PRO:DAN]		 enablesGO:0003677 DNA binding PMID:11371615
increased GO:0003700 DNA-binding transcription factor activity relative to PR:000036497 hSP1/iso:1/Clv:1 PMID:11371615
located_inGO:0005634 nucleus PMID:11371615
PR:000036499 hSP1/iso:1/Phos:1

"A transcription factor Sp1 isoform 1 phosphorylated 1 in human." [PMID:2170018, PMID:9525578, PRO:CNA]		 enablesGO:0003677 DNA binding PMID:2170018
located_inGO:0005634 nucleus PMID:2170018; PMID:9525578
PR:000036500 hSP1/iso:1/Phos:2
UniProtKB:P08047-1, Thr-579, MOD:00047
"A transcription factor Sp1 isoform 1 phosphorylated 2 in human. UniProtKB:P08047-1, Thr-579, MOD:00047." [PMID:9153193, PRO:CNA]		 enablesdecreased GO:0003700 DNA-binding transcription factor activity relative to PR:000036497 hSP1/iso:1/Clv:1 PMID:9153193
located_inGO:0005634 nucleus PMID:9153193
PR:000036501 hSP1/iso:1/Phos:3
UniProtKB:P08047-1, Ser-59, MOD:00046
"A transcription factor Sp1 isoform 1 phosphorylated 3 in human. UniProtKB:P08047-1, Ser-59, MOD:00046." [PMID:17049555, PMID:18239466, PRO:CNA]		 enablesincreased GO:0003700 DNA-binding transcription factor activity relative to PR:000036497 hSP1/iso:1/Clv:1 PMID:17049555; PMID:18239466
located_inGO:0005634 nucleus PMID:17049555; PMID:18239466
PR:000036502 hSP1/iso:1/Phos:4

"A transcription factor Sp1 isoform 1 phosphorylated 4 in human." [PMID:18171990, PRO:CNA]		 acts_upstream_of_or_withinGO:0042770 signal transduction in response to DNA damage PMID:18171990
located_inGO:0005634 nucleus PMID:18171990
PR:000036503 hSP1/iso:1/Sumo:1
UniProtKB:P08047-1, Lys-16, MOD:01149
"A transcription factor Sp1 isoform 1 sumoylated 1 in human. UniProtKB:P08047-1, Lys-16, MOD:01149." [PMID:16407261, PRO:CNA]		 enablesdecreased GO:0003700 DNA-binding transcription factor activity relative to PR:000036497 hSP1/iso:1/Clv:1 PMID:16407261
PR:P08047-1 hSP1/iso:1
transcription factor Sp1 isoform Sp1a (human)
"A transcription factor Sp1 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08047]		 located_inGO:0005634 nucleus PMID:2170018