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Protein Ontology report - BMP receptor type-1A
PR:000000035 -
http://purl.obolibrary.org/obo/PR_000000035
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000035
PRO name
BMP receptor type-1A
Synonyms
PRO-Short-label
:
EXACT:
BMPR1A
Gene-based
:
RELATED:
ACVRLK3 | ALK3 | Bmpr
Other
:
EXACT:
activin receptor-like kinase 3 | ALK-3 | BMP type-1A receptor | BMP-2/BMP-4 receptor | BMPR-1A | CD292 | serine/threonine-protein kinase receptor R5 | SKR5
Definition
"A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1A gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2 and BMP4." [PRO:CNA]
PRO Category
gene
Parent
PR:000000006
TGF-beta superfamily receptor type-1
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
3
Sequence
1
Organism-Sequence
10
Modification
3
Organism-Modification
5
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
IUPHARobj:1786
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000000035
BMP receptor type-1A, BMPR1A
organism-gene
PR:P36894
bone morphogenetic protein receptor type-1A (human), hBMPR1A
organism-sequence
PR:000000137
BMP receptor type-1A sequence variant Y62D (human), hBMPR1A/var:Y62D
Yes
organism-sequence
PR:000000138
BMP receptor type-1A sequence variant C82Y (human), hBMPR1A/var:C82Y
Yes
organism-sequence
PR:000000139
BMP receptor type-1A sequence variant C124R (human), hBMPR1A/var:C124R
Yes
organism-sequence
PR:000000140
BMP receptor type-1A sequence variant C130R (human), hBMPR1A/var:C130R
Yes
organism-sequence
PR:000000141
BMP receptor type-1A sequence variant A338D (human), hBMPR1A/var:A338D
Yes
organism-sequence
PR:000000142
BMP receptor type-1A sequence variant C376Y (human), hBMPR1A/var:C376Y
Yes
organism-sequence
PR:000000143
BMP receptor type-1A sequence variant R443C (human), hBMPR1A/var:R443C
Yes
organism-sequence
PR:000000144
BMP receptor type-1A sequence variant M470T (human), hBMPR1A/var:M470T
Yes
organism-sequence
PR:P36894-1
bone morphogenetic protein receptor type-1A isoform 1 (human), hBMPR1A/iso:1
Yes
organism-modification
PR:000036422
BMP receptor type-1A isoform 1 phosphorylated 1 (human), hBMPR1A/iso:1/Phos:1
Yes
organism-modification
PR:000036424
BMP receptor type-1A isoform 1 phosphorylated 2 (human), hBMPR1A/iso:1/Phos:2
organism-modification
PR:000046493
bone morphogenetic protein receptor type-1A, signal peptide removed form (human), hBMPR1A/SigPep-
organism-modification
PR:000046494
bone morphogenetic protein receptor type-1A, signal peptide removed phosphorylated 2 (human), hBMPR1A/SigPep-/Phos:2
organism-gene
PR:P36895
bone morphogenetic protein receptor type-1A (mouse), mBMPR1A
organism-sequence
PR:P36895-1
bone morphogenetic protein receptor type-1A isoform 1 (mouse), mBMPR1A/iso:1
Yes
organism-modification
PR:000036423
BMP receptor type-1A isoform 1 phosphorylated 1 (mouse), mBMPR1A/iso:1/Phos:1
Yes
organism-gene
PR:Q78EA7
bone morphogenetic protein receptor type-1A (rat), rBMPR1A
sequence
PR:000000136
BMP receptor type-1A isoform 1, BMPR1A/iso:1
organism-sequence
PR:P36894-1
bone morphogenetic protein receptor type-1A isoform 1 (human), hBMPR1A/iso:1
Yes
organism-modification
PR:000036422
BMP receptor type-1A isoform 1 phosphorylated 1 (human), hBMPR1A/iso:1/Phos:1
Yes
organism-modification
PR:000036424
BMP receptor type-1A isoform 1 phosphorylated 2 (human), hBMPR1A/iso:1/Phos:2
organism-sequence
PR:P36895-1
bone morphogenetic protein receptor type-1A isoform 1 (mouse), mBMPR1A/iso:1
Yes
organism-modification
PR:000036423
BMP receptor type-1A isoform 1 phosphorylated 1 (mouse), mBMPR1A/iso:1/Phos:1
Yes
modification
PR:000000382
BMP receptor type-1A isoform 1 phosphorylated form, BMPR1A/iso:1/PhosRes+
modification
PR:000000498
BMP receptor type-1A isoform 1 phosphorylated 1, BMPR1A/iso:1/Phos:1
organism-modification
PR:000036422
BMP receptor type-1A isoform 1 phosphorylated 1 (human), hBMPR1A/iso:1/Phos:1
Yes
organism-modification
PR:000036423
BMP receptor type-1A isoform 1 phosphorylated 1 (mouse), mBMPR1A/iso:1/Phos:1
Yes
modification
PR:000000499
BMP receptor type-1A isoform 1 phosphorylated 2, BMPR1A/iso:1/Phos:2
organism-modification
PR:000036424
BMP receptor type-1A isoform 1 phosphorylated 2 (human), hBMPR1A/iso:1/Phos:2
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000137
hBMPR1A/var:Y62D
UniProtKB:P36894, Tyr-62, CHEBI:29958 | BMP receptor type-1A sequence variant 1 (human)
"A bone morphogenetic protein receptor type-1A (human) that has an Asp residue at the position equivalent to Tyr-62 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Tyr-62, CHEBI:29958." [PMID:12417513, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:12417513
PR:000000138
hBMPR1A/var:C82Y
UniProtKB:P36894, Cys-82, CHEBI:46858 | BMP receptor type-1A sequence variant 2 (human)
"A bone morphogenetic protein receptor type-1A (human) that has a Tyr residue at the position equivalent to Cys-82 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-82, CHEBI:46858." [PMID:12417513, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:12417513
PR:000000139
hBMPR1A/var:C124R
UniProtKB:P36894, Cys-124, CHEBI:29952 | BMP receptor type-1A sequence variant 3 (human)
"A bone morphogenetic protein receptor type-1A (human) that has an Arg residue at the position equivalent to Cys-124 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-124, CHEBI:29952." [PMID:11536076, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:11536076
PR:000000140
hBMPR1A/var:C130R
UniProtKB:P36894, Cys-130, CHEBI:29952 | BMP receptor type-1A sequence variant 4 (human)
"A bone morphogenetic protein receptor type-1A (human) that has an Arg residue at the position equivalent to Cys-130 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-130, CHEBI:29952." [PMID:12136244, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:12136244
PR:000000141
hBMPR1A/var:A338D
UniProtKB:P36894, Ala-338, CHEBI:29958 | BMP receptor type-1A sequence variant 5 (human)
"A bone morphogenetic protein receptor type-1A (human) that has an Asp residue at the position equivalent to Ala-338 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Ala-338, CHEBI:29958." [PMID:11536076, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:6457
Cowden syndrome
PMID:11536076
PR:000000142
hBMPR1A/var:C376Y
UniProtKB:P36894, Cys-376, CHEBI:46858 | BMP receptor type-1A sequence variant 6 (human)
"A bone morphogenetic protein receptor type-1A (human) that has a Tyr residue at the position equivalent to Cys-376 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-376, CHEBI:46858." [PMID:11536076, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:11536076
PR:000000143
hBMPR1A/var:R443C
UniProtKB:P36894, Arg-443, CHEBI:29950 | BMP receptor type-1A sequence variant 7 (human)
"A bone morphogenetic protein receptor type-1A (human) that has a Cys residue at the position equivalent to Arg-443 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Arg-443, CHEBI:29950." [PMID:12417513, PMID:17344846, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:12417513
;
PMID:17344846
PR:000000144
hBMPR1A/var:M470T
UniProtKB:P36894, Met-470, CHEBI:30013 | BMP receptor type-1A sequence variant 8 (human)
"A bone morphogenetic protein receptor type-1A (human) that has a Thr residue at the position equivalent to Met-470 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Met-470, CHEBI:30013." [PMID:12630959, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:12630959
PR:000036422
hBMPR1A/iso:1/Phos:1
"A BMP receptor type-1A isoform 1 phosphorylated 1 in human." [PMID:10712517, PMID:12065756, PMID:12829744, PMID:15940369, PRO:CNA]
acts_upstream_of_or_within
GO:0006468
protein phosphorylation
PMID:12065756
GO:0030509
BMP signaling pathway
PMID:12829744
enables
GO:0004674
protein serine/threonine kinase activity
PMID:12829744
located_in
GO:0009986
cell surface
PMID:10712517
GO:0043235
receptor complex
PMID:12829744
;
PMID:15940369
PR:000036423
mBMPR1A/iso:1/Phos:1
"A BMP receptor type-1A isoform 1 phosphorylated 1 in mouse." [PMID:10814522, PMID:9738003, PRO:CNA]
enables
GO:0046332
SMAD binding
PMID:10814522
;
PMID:9738003
PR:P36894-1
hBMPR1A/iso:1
"A BMP receptor type-1A isoform 1 that is encoded in the genome of human." [PRO:CNA]
located_in
GO:0016020
membrane
PMID:8397373
GO:0043235
receptor complex
PMID:15940369
PR:P36895-1
mBMPR1A/iso:1
"A BMP receptor type-1A isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
acts_upstream_of_or_within
GO:0030509
BMP signaling pathway
PMID:10814522