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Protein Ontology report - TGF-beta receptor type-2 sequence variant V447A (human)

PR:000000063 - http://purl.obolibrary.org/obo/PR_000000063

Annotations

Ontology Information

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PAF

GPI

PRO ID

PR:000000063

PRO name

TGF-beta receptor type-2 sequence variant V447A (human)

Synonyms

PRO-Short-label:	EXACT:	hTGFBR2/var:V447A
PRO-proteoform-std:	EXACT:	UniProtKB:P37173, Val-447, CHEBI:46217
	NARROW:	UniProtKB:P37173-1, Val-447, CHEBI:46217
Other:	EXACT:	TGF-beta receptor type-2 sequence variant 7 (human)

Definition

"A TGF-beta receptor type-2 (human) that has an Ala residue at the position equivalent to Val-447 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Val-447, CHEBI:46217." [PMID:11212236, PRO:CNA, PRO:DAN]

Comment

Note: This form is involved in breast tumors.

PRO Category

organism-sequence

Parent

PR:P37173 TGF-beta receptor type-2 (human)

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy
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Related Cross References
Db identifiers	UniProtKB_VAR:VAR_022357

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000000063 hTGFBR2/var:V447A UniProtKB:P37173, Val-447, CHEBI:46217 \| UniProtKB:P37173-1, Val-447, CHEBI:46217 \| TGF-beta receptor type-2 sequence variant 7 (human) "A TGF-beta receptor type-2 (human) that has an Ala residue at the position equivalent to Val-447 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Val-447, CHEBI:46217." [PMID:11212236, PRO:CNA, PRO:DAN]	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:11212236
	enables	decreased GO:0005026 transforming growth factor beta receptor activity, type II relative to PR:000000409 TGF-beta receptor type-2 isoform 1 cleaved 1	PMID:11212236
	located_in	GO:0016020 membrane	PMID:11212236