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Documentation
Protein Ontology report - Muellerian-inhibiting factor
PR:000000073 -
http://purl.obolibrary.org/obo/PR_000000073
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
PRO ID
PR:000000073
PRO name
Muellerian-inhibiting factor
Synonyms
PRO-Short-label
:
EXACT:
AMH
Gene-based
:
RELATED:
MIF
Other
:
EXACT:
anti-Muellerian hormone | Muellerian-inhibiting substance
RELATED:
MIS
Definition
"A TGF-beta-like cystine-knot cytokine that is a translation product of the human AMH gene or a 1:1 ortholog thereof. Related to the transforming growth factor-beta, activin/inhibin, and bone morphogenic protein families which are all involved in the regulation of cell growth and differentiation." [PRO:CNA]
PRO Category
gene
Parent
PR:000000008
TGF-beta-like cystine-knot cytokine
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
3
Sequence
1
Organism-Sequence
10
Modification
5
Organism-Modification
5
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
PIRSF:PIRSF037270
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000000073
Muellerian-inhibiting factor, AMH
Yes
organism-gene
PR:P03971
Muellerian-inhibiting factor (human), hAMH
organism-sequence
PR:000000221
Muellerian-inhibiting factor sequence variant V12G (human), hAMH/var:V12G
Yes
organism-sequence
PR:000000222
Muellerian-inhibiting factor sequence variant L70P (human), hAMH/var:L70P
Yes
organism-sequence
PR:000000223
Muellerian-inhibiting factor sequence variant G101V (human), hAMH/var:G101V
Yes
organism-sequence
PR:000000224
Muellerian-inhibiting factor sequence variant R123W (human), hAMH/var:R123W
Yes
organism-sequence
PR:000000225
Muellerian-inhibiting factor sequence variant Y167C (human), hAMH/var:Y167C
Yes
organism-sequence
PR:000000226
Muellerian-inhibiting factor sequence variant R194C (human), hAMH/var:R194C
Yes
organism-sequence
PR:000000227
Muellerian-inhibiting factor sequence variant V477A (human), hAMH/var:V477A
Yes
organism-sequence
PR:P03971-1
Muellerian-inhibiting factor isoform 1 (human), hAMH/iso:1
Yes
organism-modification
PR:000036605
Muellerian-inhibiting factor isoform 1 cleaved 1 (human), hAMH/iso:1/Clv:1
Yes
organism-modification
PR:000036444
Muellerian-inhibiting factor isoform 1 cleaved and N-glycosylated 2 (human), hAMH/iso:1/ClvNGlyco:2
Yes
organism-modification
PR:000053160
Muellerian-inhibiting factor O-glycosylated 1 (human), hAMH/OGlyco:1
organism-modification
PR:000053161
Muellerian-inhibiting factor O-glycosylated 2 (human), hAMH/OGlyco:2
organism-gene
PR:P27106
Muellerian-inhibiting factor (mouse), mAmh
organism-sequence
PR:P27106-1
Muellerian-inhibiting factor isoform 1 (mouse), mAmh/iso:1
organism-gene
PR:P49000
Muellerian-inhibiting factor (rat), rAMH
organism-sequence
PR:P49000-1
Muellerian-inhibiting factor isoform 1 (rat), rAMH/iso:1
organism-modification
PR:000036606
Muellerian-inhibiting factor isoform 1 cleaved 1 (rat), rAMH/iso:1/Clv:1
Yes
sequence
PR:000000220
Muellerian-inhibiting factor isoform 1, AMH/iso:1
organism-sequence
PR:P03971-1
Muellerian-inhibiting factor isoform 1 (human), hAMH/iso:1
Yes
organism-modification
PR:000036605
Muellerian-inhibiting factor isoform 1 cleaved 1 (human), hAMH/iso:1/Clv:1
Yes
organism-modification
PR:000036444
Muellerian-inhibiting factor isoform 1 cleaved and N-glycosylated 2 (human), hAMH/iso:1/ClvNGlyco:2
Yes
organism-sequence
PR:P27106-1
Muellerian-inhibiting factor isoform 1 (mouse), mAmh/iso:1
organism-sequence
PR:P49000-1
Muellerian-inhibiting factor isoform 1 (rat), rAMH/iso:1
organism-modification
PR:000036606
Muellerian-inhibiting factor isoform 1 cleaved 1 (rat), rAMH/iso:1/Clv:1
Yes
modification
PR:000021919
Muellerian-inhibiting factor isoform 1, signal peptide removed form, AMH/iso:1/SigPep-
modification
PR:000001277
Muellerian-inhibiting factor isoform 1 cleaved 1, AMH/iso:1/Clv:1
modification
PR:000000419
Muellerian-inhibiting factor isoform 1 cleaved and glycosylated form, AMH/iso:1/ClvGlyco+
modification
PR:000000534
Muellerian-inhibiting factor isoform 1 cleaved and glycosylated 2, AMH/iso:1/ClvGlyco:2
organism-modification
PR:000036444
Muellerian-inhibiting factor isoform 1 cleaved and N-glycosylated 2 (human), hAMH/iso:1/ClvNGlyco:2
Yes
organism-modification
PR:000036605
Muellerian-inhibiting factor isoform 1 cleaved 1 (human), hAMH/iso:1/Clv:1
Yes
organism-modification
PR:000036444
Muellerian-inhibiting factor isoform 1 cleaved and N-glycosylated 2 (human), hAMH/iso:1/ClvNGlyco:2
Yes
organism-modification
PR:000036606
Muellerian-inhibiting factor isoform 1 cleaved 1 (rat), rAMH/iso:1/Clv:1
Yes
modification
PR:000001276
Muellerian-inhibiting factor proteolytic cleavage product, AMH/ClvPrd
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000073
AMH
MIF | anti-Muellerian hormone | Muellerian-inhibiting substance | MIS
"A TGF-beta-like cystine-knot cytokine that is a translation product of the human AMH gene or a 1:1 ortholog thereof. Related to the transforming growth factor-beta, activin/inhibin, and bone morphogenic protein families which are all involved in the regulation of cell growth and differentiation." [PRO:CNA]
acts_upstream_of_or_within
GO:0007548
sex differentiation
PIRSF:PIRSF037270
GO:0008406
gonad development
PIRSF:PIRSF037270
enables
GO:0005102
signaling receptor binding
PIRSF:PIRSF037270
GO:0005179
hormone activity
PIRSF:PIRSF037270
PR:000000221
hAMH/var:V12G
UniProtKB:P03971, Val-12, CHEBI:29947 | anti-Muellerian hormone sequence variant 1 (human)
"A Muellerian-inhibiting factor (human) that has a Gly residue at the position equivalent to Val-12 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Val-12, CHEBI:29947." [PMID:8162013, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050791
persistent Mullerian duct syndrome
PMID:8162013
PR:000000222
hAMH/var:L70P
UniProtKB:P03971, Leu-70, CHEBI:50342 | anti-Muellerian hormone sequence variant 2 (human)
"A Muellerian-inhibiting factor (human) that has a Pro residue at the position equivalent to Leu-70 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Leu-70, CHEBI:50342." [PMID:8162013, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050791
persistent Mullerian duct syndrome
PMID:8162013
PR:000000223
hAMH/var:G101V
UniProtKB:P03971, Gly-101, CHEBI:30015 | anti-Muellerian hormone sequence variant 3 (human)
"A Muellerian-inhibiting factor (human) that has a Val residue at the position equivalent to Gly-101 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Gly-101, CHEBI:30015." [PMID:8162013, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050791
persistent Mullerian duct syndrome
PMID:8162013
PR:000000224
hAMH/var:R123W
UniProtKB:P03971, Arg-123, CHEBI:29954 | anti-Muellerian hormone sequence variant 4 (human)
"A Muellerian-inhibiting factor (human) that has a Trp residue at the position equivalent to Arg-123 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Arg-123, CHEBI:29954." [PMID:8162013, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050791
persistent Mullerian duct syndrome
PMID:8162013
PR:000000225
hAMH/var:Y167C
UniProtKB:P03971, Tyr-167, CHEBI:29950 | anti-Muellerian hormone sequence variant 5 (human)
"A Muellerian-inhibiting factor (human) that has a Cys residue at the position equivalent to Tyr-167 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Tyr-167, CHEBI:29950." [PMID:8162013, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050791
persistent Mullerian duct syndrome
PMID:8162013
PR:000000226
hAMH/var:R194C
UniProtKB:P03971, Arg-194, CHEBI:29950 | anti-Muellerian hormone sequence variant 6 (human)
"A Muellerian-inhibiting factor (human) that has a Cys residue at the position equivalent to Arg-194 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Arg-194, CHEBI:29950." [PMID:14673134, PMID:8162013, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050791
persistent Mullerian duct syndrome
PMID:14673134
;
PMID:8162013
located_in
SO:0001555
decreased_translational_product_level
PMID:14673134
;
PMID:8162013
SO:0001558
polypeptide_localization_variant
PMID:14673134
;
PMID:8162013
PR:000000227
hAMH/var:V477A
UniProtKB:P03971, Val-477, CHEBI:46217 | anti-Muellerian hormone sequence variant 7 (human)
"A Muellerian-inhibiting factor (human) that has an Ala residue at the position equivalent to Val-477 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Val-477, CHEBI:46217." [PMID:8162013, PRO:CNA, PRO:DAN]
located_in
SO:0001558
polypeptide_localization_variant
PMID:8162013
PR:000036444
hAMH/iso:1/ClvNGlyco:2
UniProtKB:P03971-1, 26-450, 451-560, MOD:00160
"A Muellerian-inhibiting factor isoform 1 cleaved and glycosylated 2 in human, in which the cleaved parts remain joined by disulfide bonds. The position(s) of glycosylation sites have not been experimentally determined. UniProtKB:P03971-1, 26-450, 451-560, MOD:00160." [PMID:12834017, PMID:14673134, PMID:14750901, PMID:3754790, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0001880
Mullerian duct regression
PMID:14750901
;
PMID:3754790
GO:0007267
cell-cell signaling
PMID:3754790
GO:0007548
sex differentiation
PMID:12834017
enables
GO:0005102
signaling receptor binding
PMID:14750901
GO:0005179
hormone activity
PMID:14750901
GO:0046983
protein dimerization activity
PMID:14673134
located_in
GO:0005576
extracellular region
PMID:14750901
;
PMID:3754790
PR:000036605
hAMH/iso:1/Clv:1
UniProtKB:P03971-1, 451-560
"A Muellerian-inhibiting factor isoform 1 cleaved 1 in human. UniProtKB:P03971-1, 451-560." [PMID:14673134, PRO:CNA]
enables
GO:0046983
protein dimerization activity
PMID:14673134
PR:000036606
rAMH/iso:1/Clv:1
UniProtKB:P49000-1, 446-553
"A Muellerian-inhibiting factor isoform 1 cleaved 1 in rat. UniProtKB:P49000-1, 446-553." [PMID:8755541, PRO:CNA]
located_in
GO:0005576
extracellular region
PMID:8755541
PR:P03971-1
hAMH/iso:1
"A Muellerian-inhibiting factor isoform 1 that is encoded in the genome of human." [PRO:CNA]
acts_upstream_of_or_within
GO:0001880
Mullerian duct regression
PMID:14750901
GO:0007548
sex differentiation
PMID:12834017