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Protein Ontology report - lefty protein
PR:000000102 - http://purl.obolibrary.org/obo/PR_000000102
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000102   
  PRO namelefty protein 
  Definition"A TGF-beta-like cystine-knot cytokine that is an antagonist of nodal signaling. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000008 TGF-beta-like cystine-knot cytokine
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 2                                        
         Sequence2                                                  Organism-Sequence 6                                        
         Modification6                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037402
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000102 lefty protein, LTBP1
Yes
gene


PR:000000287 lefty 1, LEFTY1

organism-gene


PR:O75610 left-right determination factor 1 (human), hLEFTY1

organism-sequence


PR:O75610-1 left-right determination factor 1 isoform 1 (human), hLEFTY1/iso:1

organism-modification


PR:000036546 lefty 1 isoform 1 cleaved 1 (human), hLEFTY1/iso:1/Clv:1
Yes
organism-modification


PR:000036548 lefty 1 isoform 1 cleaved 2 (human), hLEFTY1/iso:1/Clv:2
Yes
organism-modification


PR:000077301 left-right determination factor 1 phosphorylated 1 (human), hLEFTY1/Phos:1

sequence


PR:000000450 lefty 1 isoform 1, LEFTY1/iso:1

organism-sequence


PR:O75610-1 left-right determination factor 1 isoform 1 (human), hLEFTY1/iso:1

organism-modification


PR:000036546 lefty 1 isoform 1 cleaved 1 (human), hLEFTY1/iso:1/Clv:1
Yes
organism-modification


PR:000036548 lefty 1 isoform 1 cleaved 2 (human), hLEFTY1/iso:1/Clv:2
Yes
organism-sequence


PR:Q64280-1 left-right determination factor 1 isoform 1 (mouse), mLEFTY1/iso:1
Yes
organism-modification


PR:000036547 lefty 1 isoform 1 cleaved 1 (mouse), mLEFTY1/iso:1/Clv:1
Yes
modification


PR:000000643 lefty 1 isoform 1 cleaved 1, LEFTY1/iso:1/Clv:1

organism-modification


PR:000036546 lefty 1 isoform 1 cleaved 1 (human), hLEFTY1/iso:1/Clv:1
Yes
organism-modification


PR:000036547 lefty 1 isoform 1 cleaved 1 (mouse), mLEFTY1/iso:1/Clv:1
Yes
modification


PR:000000644 lefty 1 isoform 1 cleaved 2, LEFTY1/iso:1/Clv:2

organism-modification


PR:000036548 lefty 1 isoform 1 cleaved 2 (human), hLEFTY1/iso:1/Clv:2
Yes
modification


PR:000025431 lefty 1 proteolytic cleavage product, LEFTY1/ClvPrd

modification


PR:000000643 lefty 1 isoform 1 cleaved 1, LEFTY1/iso:1/Clv:1

organism-modification


PR:000036546 lefty 1 isoform 1 cleaved 1 (human), hLEFTY1/iso:1/Clv:1
Yes
organism-modification


PR:000036547 lefty 1 isoform 1 cleaved 1 (mouse), mLEFTY1/iso:1/Clv:1
Yes
modification


PR:000000644 lefty 1 isoform 1 cleaved 2, LEFTY1/iso:1/Clv:2

organism-modification


PR:000036548 lefty 1 isoform 1 cleaved 2 (human), hLEFTY1/iso:1/Clv:2
Yes
gene


PR:000000288 lefty 2, LEFTY2

organism-gene


PR:O00292 left-right determination factor 2 (human), hLEFTY2

organism-sequence


PR:000000452 lefty 2 sequence variant S342N (human), hLEFTY2/var:S342N
Yes
organism-sequence


PR:O00292-1 left-right determination factor 2 isoform 1 (human), hLEFTY2/iso:1
Yes
organism-modification


PR:000036549 lefty 2 isoform 1 cleaved 1 (human), hLEFTY2/iso:1/Clv:1
Yes
organism-modification


PR:000036550 lefty 2 isoform 1 cleaved 2 (human), hLEFTY2/iso:1/Clv:2
Yes
organism-sequence


PR:O00292-2 left-right determination factor 2 isoform h2 (human), hLEFTY2/iso:h2

organism-modification


PR:000048185 left-right determination factor 2, signal peptide removed form (human), hLEFTY2/SigPep-

organism-modification


PR:000083292 left-right determination factor 2 phosphorylated 1 (human), hLEFTY2/Phos:1

sequence


PR:000000451 lefty 2 isoform 1, LEFTY2/iso:1

organism-sequence


PR:O00292-1 left-right determination factor 2 isoform 1 (human), hLEFTY2/iso:1
Yes
organism-modification


PR:000036549 lefty 2 isoform 1 cleaved 1 (human), hLEFTY2/iso:1/Clv:1
Yes
organism-modification


PR:000036550 lefty 2 isoform 1 cleaved 2 (human), hLEFTY2/iso:1/Clv:2
Yes
organism-sequence


PR:P57785-1 left-right determination factor 2 isoform 1 (mouse), mLEFTY2/iso:1

modification


PR:000000645 lefty 2 isoform 1 cleaved 1, LEFTY2/iso:1/Clv:1

organism-modification


PR:000036549 lefty 2 isoform 1 cleaved 1 (human), hLEFTY2/iso:1/Clv:1
Yes
modification


PR:000000646 lefty 2 isoform 1 cleaved 2, LEFTY2/iso:1/Clv:2

organism-modification


PR:000036550 lefty 2 isoform 1 cleaved 2 (human), hLEFTY2/iso:1/Clv:2
Yes
modification


PR:000025432 lefty 2 proteolytic cleavage product, LEFTY2/ClvPrd

modification


PR:000000645 lefty 2 isoform 1 cleaved 1, LEFTY2/iso:1/Clv:1

organism-modification


PR:000036549 lefty 2 isoform 1 cleaved 1 (human), hLEFTY2/iso:1/Clv:1
Yes
modification


PR:000000646 lefty 2 isoform 1 cleaved 2, LEFTY2/iso:1/Clv:2

organism-modification


PR:000036550 lefty 2 isoform 1 cleaved 2 (human), hLEFTY2/iso:1/Clv:2
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000102 LTBP1

"A TGF-beta-like cystine-knot cytokine that is an antagonist of nodal signaling. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007275 multicellular organism development PIRSF:PIRSF037402
PR:000000452 hLEFTY2/var:S342N
UniProtKB:O00292, Ser-342, CHEBI:50347 | UniProtKB:O00292-1, Ser-342, CHEBI:50347 | lefty 2 sequence variant 1 (human)
"A left-right determination factor 2 (human) that has an Asn residue at the position equivalent to Ser-342 of the amino acid sequence represented by UniProtKB:O00292-1. Example: UniProtKB:O00292-1, Ser-342, CHEBI:50347." [PMID:10053005, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050545 visceral heterotaxy PMID:10053005
PR:000036546 hLEFTY1/iso:1/Clv:1
UniProtKB:O75610-1, 77-366 | PRO_0000033811
"A lefty 1 isoform 1 cleaved 1 in human. UniProtKB:O75610-1, 77-366." [PMID:11278322, PRO:CNA]		 located_inGO:0005615 extracellular space PMID:11278322
PR:000036547 mLEFTY1/iso:1/Clv:1
UniProtKB:Q64280-1, 77-368 | PRO_0000033809
"A lefty 1 isoform 1 cleaved 1 in mouse. UniProtKB:Q64280-1, 77-368." [PMID:15004567, PMID:18039650, PRO:CNA]		 acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:15004567
GO:0009948 anterior/posterior axis specification PMID:15004567
located_inGO:0005615 extracellular space PMID:18039650
PR:000036548 hLEFTY1/iso:1/Clv:2
UniProtKB:O75610-1, 135-366
"A lefty 1 isoform 1 cleaved 2 in human. UniProtKB:O75610-1, 135-366." [PMID:11278322, PRO:CNA]		 acts_upstream_of_or_withinGO:0043406 positive regulation of MAP kinase activity PMID:11278322
located_inGO:0005615 extracellular space PMID:11278322
PR:000036549 hLEFTY2/iso:1/Clv:1
UniProtKB:O00292-1, 77-366 | PRO_0000033807
"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]		 acts_upstream_of_or_withinGO:0007275 multicellular organism development PMID:10053005
GO:0007309 oocyte axis specification PMID:10053005
located_inGO:0005615 extracellular space PMID:11278322
PR:000036550 hLEFTY2/iso:1/Clv:2
UniProtKB:O00292-1, 135-366
"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]		 acts_upstream_of_or_withinGO:0043406 positive regulation of MAP kinase activity PMID:11278322
located_inGO:0005615 extracellular space PMID:11278322
PR:O00292-1 hLEFTY2/iso:1

"A lefty 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007275 multicellular organism development PMID:10053005
GO:0007309 oocyte axis specification PMID:10053005
PR:Q64280-1 mLEFTY1/iso:1

"A lefty 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:15004567
GO:0009948 anterior/posterior axis specification PMID:15004567