Home
|
Linked Open Data
|
Browse
|
Search
|
Statistics
|
Download
RACE-PRO
PRO tracker
Community
PRO Consortium
Publications
Documentation
Protein Ontology report - nodal protein
PR:000000105 -
http://purl.obolibrary.org/obo/PR_000000105
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
PRO ID
PR:000000105
PRO name
nodal protein
Synonyms
PRO-Short-label
:
EXACT:
NODAL
Definition
"A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [PRO:CNA]
PRO Category
gene
Parent
PR:000000008
TGF-beta-like cystine-knot cytokine
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
2
Sequence
1
Organism-Sequence
3
Modification
2
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
Back to top
Related Cross References
Db identifiers
PIRSF:PIRSF037400
Back to top
Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000000105
nodal protein, NODAL
Yes
organism-gene
PR:P43021
nodal (mouse), mNODAL
organism-sequence
PR:P43021-1
nodal isoform 1 (mouse), mNODAL/iso:1
Yes
organism-modification
PR:000036469
nodal protein isoform 1, signal peptide removed form (mouse), mNODAL/iso:1/SigPep-
Yes
organism-gene
PR:Q96S42
nodal homolog (human), hNODAL
organism-sequence
PR:000000292
nodal protein sequence variant R183Q (human), hNODAL/var:R183Q
Yes
organism-sequence
PR:Q96S42-1
nodal homolog isoform 1 (human), hNODAL/iso:1
organism-modification
PR:000048620
nodal homolog, signal peptide removed form (human), hNODAL/SigPep-
sequence
PR:000000291
nodal protein isoform 1, NODAL/iso:1
organism-sequence
PR:P43021-1
nodal isoform 1 (mouse), mNODAL/iso:1
Yes
organism-modification
PR:000036469
nodal protein isoform 1, signal peptide removed form (mouse), mNODAL/iso:1/SigPep-
Yes
organism-sequence
PR:Q96S42-1
nodal homolog isoform 1 (human), hNODAL/iso:1
modification
PR:000000558
nodal protein isoform 1, signal peptide removed form, NODAL/iso:1/SigPep-
organism-modification
PR:000036469
nodal protein isoform 1, signal peptide removed form (mouse), mNODAL/iso:1/SigPep-
Yes
modification
PR:000025433
nodal protein proteolytic cleavage product, NODAL/ClvPrd
Back to top
Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000105
NODAL
"A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [PRO:CNA]
acts_upstream_of_or_within
GO:0007368
determination of left/right symmetry
PIRSF:PIRSF037400
enables
GO:0016015
morphogen activity
PIRSF:PIRSF037400
PR:000000292
hNODAL/var:R183Q
UniProtKB:Q96S42, Arg-183, CHEBI:30011 | nodal protein sequence variant 1 (human)
"A nodal homolog (human) that has a Gln residue at the position equivalent to Arg-183 of the amino acid sequence represented by UniProtKB:Q96S42. UniProtKB:Q96S42, Arg-183, CHEBI:30011." [PMID:9354794, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050545
visceral heterotaxy
PMID:9354794
PR:000036469
mNODAL/iso:1/SigPep-
UniProtKB:P43021-1, 27-354
"A nodal protein isoform 1, signal peptide removed form in mouse. UniProtKB:P43021-1, 27-354." [PMID:12654299, PMID:15004567, PMID:15649361, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007368
determination of left/right symmetry
PMID:12654299
GO:0009952
anterior/posterior pattern specification
PMID:15004567
enables
GO:0042803
protein homodimerization activity
PMID:15649361
located_in
GO:0005615
extracellular space
PMID:15649361
PR:P43021-1
mNODAL/iso:1
"A nodal protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
acts_upstream_of_or_within
GO:0007368
determination of left/right symmetry
PMID:12654299
GO:0009952
anterior/posterior pattern specification
PMID:15004567
enables
GO:0042803
protein homodimerization activity
PMID:15649361
located_in
GO:0005615
extracellular space
PMID:15649361
