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Protein Ontology report - Rho-associated protein kinase 2
PR:000000121 - http://purl.obolibrary.org/obo/PR_000000121
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000121   
  PRO nameRho-associated protein kinase 2 
  Synonyms
PRO-Short-label: EXACT:ROCK2
Gene-based: RELATED:KIAA0619
Other: EXACT:p164 ROCK-2 | rho kinase 2 | rho-associated, coiled-coil-containing protein kinase 2 | Rho-associated, coiled-coil-containing protein kinase II | ROCK-II
  Definition"A Rho-associated protein kinase that is a translation product of the human ROCK2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000024 Rho-associated protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 3                                        
         Modification6                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1504
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000121 Rho-associated protein kinase 2, ROCK2

organism-gene


PR:O75116 Rho-associated protein kinase 2 (human), hROCK2

organism-sequence


PR:O75116-1 Rho-associated protein kinase 2 isoform 1 (human), hROCK2/iso:1
Yes
organism-modification


PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human), hROCK2/iso:1/Clv:1
Yes
organism-modification


PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human), hROCK2/iso:1/Phos:1
Yes
organism-modification


PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human), hROCK2/iso:1/Phos:2
Yes
organism-modification


PR:000066276 Rho-associated protein kinase 2 methylated 1 (human), hROCK2/Me:1

organism-modification


PR:000071951 Rho-associated protein kinase 2 methylated 2 (human), hROCK2/Me:2

organism-modification


PR:000074887 Rho-associated protein kinase 2 phosphorylated 1 (human), hROCK2/Phos:1

organism-gene


PR:P70336 Rho-associated protein kinase 2 (mouse), mROCK2

organism-sequence


PR:P70336-1 Rho-associated protein kinase 2 isoform 1 (mouse), mROCK2/iso:1

organism-sequence


PR:P70336-2 Rho-associated protein kinase 2 isoform 2 (mouse), mROCK2/iso:2
Yes
organism-gene


PR:Q62868 Rho-associated protein kinase 2 (rat), rROCK2

sequence


PR:000000308 Rho-associated protein kinase 2 isoform 1, ROCK2/iso:1

organism-sequence


PR:O75116-1 Rho-associated protein kinase 2 isoform 1 (human), hROCK2/iso:1
Yes
organism-modification


PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human), hROCK2/iso:1/Clv:1
Yes
organism-modification


PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human), hROCK2/iso:1/Phos:1
Yes
organism-modification


PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human), hROCK2/iso:1/Phos:2
Yes
organism-sequence


PR:P70336-1 Rho-associated protein kinase 2 isoform 1 (mouse), mROCK2/iso:1

modification


PR:000000462 Rho-associated protein kinase 2 isoform 1 phosphorylated form, ROCK2/iso:1/PhosRes+

modification


PR:000000565 Rho-associated protein kinase 2 isoform 1 phosphorylated 1, ROCK2/iso:1/Phos:1

organism-modification


PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human), hROCK2/iso:1/Phos:1
Yes
modification


PR:000000566 Rho-associated protein kinase 2 isoform 1 phosphorylated 2, ROCK2/iso:1/Phos:2

organism-modification


PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human), hROCK2/iso:1/Phos:2
Yes
modification


PR:000000564 Rho-associated protein kinase 2 isoform 1 cleaved 1, ROCK2/iso:1/Clv:1

organism-modification


PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human), hROCK2/iso:1/Clv:1
Yes
modification


PR:000002530 Rho-associated protein kinase 2 isoform 1 unmodified form, ROCK2/iso:1/UnMod

sequence


PR:000000309 Rho-associated protein kinase 2 isoform 2, ROCK2/iso:2

organism-sequence


PR:P70336-2 Rho-associated protein kinase 2 isoform 2 (mouse), mROCK2/iso:2
Yes
modification


PR:000025436 Rho-associated protein kinase 2 proteolytic cleavage product, ROCK2/ClvPrd

modification


PR:000000564 Rho-associated protein kinase 2 isoform 1 cleaved 1, ROCK2/iso:1/Clv:1

organism-modification


PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human), hROCK2/iso:1/Clv:1
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036477 hROCK2/iso:1/Clv:1
UniProtKB:O75116-1, 1-1131
"A Rho-associated protein kinase 2 isoform 1 cleaved 1 in human. UniProtKB:O75116-1, 1-1131." [PMID:15699075, PRO:CNA]		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:15699075
GO:0030036 actin cytoskeleton organization PMID:15699075
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000002530 ROCK2/iso:1/UnMod PMID:15699075
located_inGO:0005622 intracellular anatomical structure PMID:15699075
PR:000036478 hROCK2/iso:1/Phos:1
UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046
"A Rho-associated protein kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046." [PMID:15302935, PMID:17446864, PRO:CNA]		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:17446864
enablesGO:0004674 protein serine/threonine kinase activity PMID:17446864
located_inGO:0005634 nucleus PMID:15302935
PR:000036479 hROCK2/iso:1/Phos:2
UniProtKB:O75116-1, Thr-1078, MOD:00047
"A Rho-associated protein kinase 2 isoform 1 phosphorylated 2 in human. UniProtKB:O75116-1, Thr-1078, MOD:00047." [PMID:17525332, PRO:CNA]		 acts_upstream_of_or_withinGO:0042770 signal transduction in response to DNA damage PMID:17525332
PR:O75116-1 hROCK2/iso:1

"A Rho-associated protein kinase 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:9933571
GO:0051260 protein homooligomerization PMID:15291762
enablesGO:0004674 protein serine/threonine kinase activity PMID:9933571
GO:0031267 small GTPase binding PMID:11350930
located_inGO:0005622 intracellular anatomical structure PMID:16574662
PR:P70336-2 mROCK2/iso:2
rho-associated protein kinase 2 isoform ROCK2m (mouse)
"A Rho-associated protein kinase 2 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:17606625
GO:0051149 positive regulation of muscle cell differentiation PMID:17606625
enablesGO:0004674 protein serine/threonine kinase activity PMID:17606625