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Protein Ontology report - thrombospondin-1
PR:000000129 - http://purl.obolibrary.org/obo/PR_000000129
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000129   
  PRO namethrombospondin-1 
  Synonyms
PRO-Short-label: EXACT:THBS1
Gene-based: RELATED:TSP | TSP1
Other: EXACT:glycoprotein G
  Definition"A thrombospondin subgroup A that is a translation product of the human THBS1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000029 thrombospondin subgroup A
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification7                                                  Organism-Modification 21                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000129 thrombospondin-1, THBS1
Yes
organism-gene


PR:P07996 thrombospondin-1 (human), hTHBS1

organism-sequence


PR:P07996-1 thrombospondin-1 isoform 1 (human), hTHBS1/iso:1

organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human), hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human), hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human), hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000028966 thrombospondin-1 isoform 1 cleaved 2 (human), hTHBS1/iso:1/Clv:2

organism-sequence


PR:P07996-2 thrombospondin-1 isoform 2 (human), hTHBS1/iso:2

organism-modification


PR:000028410 thrombospondin-1, signal peptide removed form (human), hTHBS1/SigPep-
Yes
Yes
organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human), hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human), hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human), hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000054414 thrombospondin-1 N-glycosylated 1 (human), hTHBS1/NGlyco:1

organism-modification


PR:000054415 thrombospondin-1 N-glycosylated 2 (human), hTHBS1/NGlyco:2

organism-modification


PR:000054416 thrombospondin-1 N-glycosylated 3 (human), hTHBS1/NGlyco:3

organism-modification


PR:000054418 thrombospondin-1 N-glycosylated 5 (human), hTHBS1/NGlyco:5

organism-modification


PR:000054419 thrombospondin-1 N-glycosylated 6 (human), hTHBS1/NGlyco:6

organism-modification


PR:000060409 thrombospondin-1, signal peptide removed fucosylserine form (human), hTHBS1/SigPep-/FucSer+

organism-modification


PR:000064777 thrombospondin-1, signal peptide removed O-glycosylserine form (human), hTHBS1/SigPep-/OGlycoSer+

organism-modification


PR:000073784 thrombospondin-1 methylated 1 (human), hTHBS1/Me:1

organism-modification


PR:000076437 thrombospondin-1 deaminated 1 (human), hTHBS1/Deam:1

organism-modification


PR:000079618 thrombospondin-1 cysteinylated 1 (human), hTHBS1/Cyst:1

organism-modification


PR:000079709 thrombospondin-1 cysteinylated 2 (human), hTHBS1/Cyst:2

organism-gene


PR:P35441 thrombospondin-1 (mouse), mTHBS1

organism-sequence


PR:P35441-1 thrombospondin-1 isoform 1 (mouse), mTHBS1/iso:1

organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse), mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse), mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse), mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
organism-modification


PR:000036486 thrombospondin-1 isoform 1 cleaved 2 (mouse), mTHBS1/iso:1/Clv:2
Yes
organism-modification


PR:000044495 thrombospondin-1, signal peptide removed form (mouse), mTHBS1/SigPep-
Yes
organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse), mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse), mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse), mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
sequence


PR:000000376 thrombospondin-1 isoform 1, THBS1/iso:1

organism-sequence


PR:P07996-1 thrombospondin-1 isoform 1 (human), hTHBS1/iso:1

organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human), hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human), hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human), hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000028966 thrombospondin-1 isoform 1 cleaved 2 (human), hTHBS1/iso:1/Clv:2

organism-sequence


PR:P35441-1 thrombospondin-1 isoform 1 (mouse), mTHBS1/iso:1

organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse), mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse), mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse), mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
organism-modification


PR:000036486 thrombospondin-1 isoform 1 cleaved 2 (mouse), mTHBS1/iso:1/Clv:2
Yes
modification


PR:000000587 thrombospondin-1 isoform 1, signal peptide removed form, THBS1/iso:1/SigPep-

modification


PR:000000485 thrombospondin-1 isoform 1 cleaved and glycosylated form, THBS1/iso:1/ClvGlyco+

modification


PR:000000590 thrombospondin-1 isoform 1 cleaved 2 glycosylated form, THBS1/iso:1/Clv:2/GlycoRes+

organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human), hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse), mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification


PR:000000589 thrombospondin-1 isoform 1, signal peptide removed glycosylated form, THBS1/iso:1/SigPep-/GlycoRes+

organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse), mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human), hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human), hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human), hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human), hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse), mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse), mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse), mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification


PR:000000588 thrombospondin-1 isoform 1 cleaved 2, THBS1/iso:1/Clv:2

organism-modification


PR:000028966 thrombospondin-1 isoform 1 cleaved 2 (human), hTHBS1/iso:1/Clv:2

organism-modification


PR:000036486 thrombospondin-1 isoform 1 cleaved 2 (mouse), mTHBS1/iso:1/Clv:2
Yes
modification


PR:000018282 thrombospondin-1, signal peptide removed form, THBS1/SigPep-

modification


PR:000000587 thrombospondin-1 isoform 1, signal peptide removed form, THBS1/iso:1/SigPep-

modification


PR:000000485 thrombospondin-1 isoform 1 cleaved and glycosylated form, THBS1/iso:1/ClvGlyco+

modification


PR:000000590 thrombospondin-1 isoform 1 cleaved 2 glycosylated form, THBS1/iso:1/Clv:2/GlycoRes+

organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human), hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse), mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification


PR:000000589 thrombospondin-1 isoform 1, signal peptide removed glycosylated form, THBS1/iso:1/SigPep-/GlycoRes+

organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse), mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human), hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human), hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human), hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human), hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse), mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse), mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse), mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
organism-modification


PR:000028410 thrombospondin-1, signal peptide removed form (human), hTHBS1/SigPep-
Yes
Yes
organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human), hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human), hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human), hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000044495 thrombospondin-1, signal peptide removed form (mouse), mTHBS1/SigPep-
Yes
organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse), mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse), mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse), mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification


PR:000025437 thrombospondin-1 proteolytic cleavage product, THBS1/ClvPrd

modification


PR:000000485 thrombospondin-1 isoform 1 cleaved and glycosylated form, THBS1/iso:1/ClvGlyco+

modification


PR:000000590 thrombospondin-1 isoform 1 cleaved 2 glycosylated form, THBS1/iso:1/Clv:2/GlycoRes+

organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human), hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse), mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification


PR:000000588 thrombospondin-1 isoform 1 cleaved 2, THBS1/iso:1/Clv:2

organism-modification


PR:000028966 thrombospondin-1 isoform 1 cleaved 2 (human), hTHBS1/iso:1/Clv:2

organism-modification


PR:000036486 thrombospondin-1 isoform 1 cleaved 2 (mouse), mTHBS1/iso:1/Clv:2
Yes
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THBS1 forms found in complexes   

THBS1 Component
 Complexes
PR:000028410 hTHBS1/SigPep- PR:000028445 integrin alphaIIbbeta3:thrombospondin 1 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000129 THBS1
TSP | TSP1 | glycoprotein G
"A thrombospondin subgroup A that is a translation product of the human THBS1 gene or a 1:1 ortholog thereof." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007596 blood coagulation PANTHER:PTHR10199
PR:000026338 hTHBS1/iso:1/SigPep-
UniProtKB:P07996-1, 19-1170 | PRO_0000035842
"A thrombospondin-1 isoform 1, signal peptide removed form in human. UniProtKB:P07996-1, 19-1170." [PRO:DNx, UniProtKB:P07996]		 enablesGO:0004866 endopeptidase inhibitor activity PMID:8751720
located_inGO:0005615 extracellular space PMID:15662972
PR:000028410 hTHBS1/SigPep-
UniProtKB:P07996, 19-1170 | UniProtKB:P07996-1, 19-1170 | PRO_0000035842
"A thrombospondin-1, signal peptide removed form in human. Example: UniProtKB:P07996-1, 19-1170." [PRO:DNx]		 located_inGO:0005615 extracellular space PMID:15662972
PR:000036485 mTHBS1/iso:1/SigPep-
UniProtKB:P35441-1, 19-1170
"A thrombospondin-1 isoform 1, signal peptide removed form in mouse. UniProtKB:P35441-1, 19-1170." [PMID:12498716, PRO:CNA]		 located_inGO:0005615 extracellular space PMID:12498716
PR:000036486 mTHBS1/iso:1/Clv:2
UniProtKB:P35441-1, 19-311
"A thrombospondin-1 isoform 1 cleaved 2 in mouse. UniProtKB:P35441-1, 19-311." [PMID:17082774, PRO:CNA]		 acts_upstream_of_or_withinGO:0016525 negative regulation of angiogenesis PMID:17082774
GO:0060055 angiogenesis involved in wound healing PMID:17082774
enablesGO:0042802 identical protein binding with PR:000036486 mTHBS1/iso:1/Clv:2 PMID:17082774
PR:000036487 mTHBS1/iso:1/SigPep-/GlycoRes+
UniProtKB:P35441-1, 19-1170, MOD:00222|MOD:00812|MOD:00813 | PRO_0000035843, MOD:00222|MOD:00812|MOD:00813
"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P35441-1, 19-1170, MOD:00222|MOD:00812|MOD:00813." [PMID:1459996, PMID:9657149, PRO:CNA]		 enablesGO:0005515 protein binding with PR:000036486 mTHBS1/iso:1/Clv:2 PMID:1459996
GO:0050431 transforming growth factor beta binding PMID:9657149
located_inGO:0005615 extracellular space PMID:9657149
PR:000036488 hTHBS1/iso:1/SigPep-/Glyco:1
UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813 | PRO_0000035842, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813
"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form that is in human and has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PMID:12450399, PMID:15342643, PMID:3305519, PRO:CNA]		 enablesGO:0005515 protein binding with PR:000028966 hTHBS1/iso:1/Clv:2 PMID:3305519
GO:0050431 transforming growth factor beta binding PMID:15342643
PR:000036490 mTHBS1/iso:1/Clv:2/GlycoRes+
UniProtKB:P35441-1, 312-1170, MOD:00693
"A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in mouse. UniProtKB:P35441-1, 312-1170, MOD:00693." [PMID:17082774, PRO:CNA]		 acts_upstream_of_or_withinGO:0016525 negative regulation of angiogenesis PMID:17082774
GO:0060055 angiogenesis involved in wound healing PMID:17082774
PR:000044495 mTHBS1/SigPep-
UniProtKB:P35441, 19-1170 | PRO_0000035843
"A thrombospondin-1, signal peptide removed form in mouse. UniProtKB:P35441, 19-1170." [PMID:12498716, PMID:8654563, PRO:CNA]		 located_inGO:0005615 extracellular space PMID:12498716