back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - TGF-beta 1
PR:000000182 - http://purl.obolibrary.org/obo/PR_000000182
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000182   
  PRO nameTGF-beta 1 
  Synonyms
PRO-Short-label: EXACT:TGFB1
Gene-based: RELATED:TGFB
Other: EXACT:TGF-beta-1
  Definition"A TGF-beta that is a translation product of the human TGFB1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000046
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 9                                        
         Modification7                                                  Organism-Modification 26                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000182 TGF-beta 1, TGFB1
Yes
organism-gene


PR:P01137 transforming growth factor beta-1 (human), hTGFB1

organism-sequence


PR:000000398 TGF-beta 1 sequence variant L10P (human), hTGFB1/var:L10P
Yes
organism-sequence


PR:000000399 TGF-beta 1 sequence variant T81H (human), hTGFB1/var:T81H
Yes
organism-modification


PR:000021903 TGF-beta 1 sequence variant T81H, signal peptide removed form (human), hTGFB1/var:T81H/SigPep-

organism-modification


PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human), hTGFB1/var:T81H/Clv:1
Yes
organism-modification


PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human), hTGFB1/var:T81H/Clv:2
Yes
organism-sequence


PR:000000400 TGF-beta 1 sequence variant R218C (human), hTGFB1/var:R218C
Yes
organism-modification


PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human), hTGFB1/var:R218C/SigPep-

organism-modification


PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human), hTGFB1/var:R218C/Clv:1
Yes
organism-modification


PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human), hTGFB1/var:R218C/Clv:2
Yes
organism-sequence


PR:000000401 TGF-beta 1 sequence variant R218H (human), hTGFB1/var:R218H
Yes
organism-modification


PR:000021907 TGF-beta 1 sequence variant R218H, signal peptide removed form (human), hTGFB1/var:R218H/SigPep-

organism-modification


PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human), hTGFB1/var:R218H/Clv:1
Yes
organism-modification


PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human), hTGFB1/var:R218H/Clv:2
Yes
organism-sequence


PR:000000402 TGF-beta 1 sequence variant H222D (human), hTGFB1/var:H222D
Yes
organism-modification


PR:000021905 TGF-beta 1 sequence variant H222D, signal peptide removed form (human), hTGFB1/var:H222D/SigPep-

organism-modification


PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human), hTGFB1/var:H222D/Clv:1
Yes
organism-modification


PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human), hTGFB1/var:H222D/Clv:2
Yes
organism-sequence


PR:000000403 TGF-beta 1 sequence variant C225R (human), hTGFB1/var:C225R
Yes
organism-modification


PR:000021906 TGF-beta 1 sequence variant C225R, signal peptide removed form (human), hTGFB1/var:C225R/SigPep-

organism-modification


PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human), hTGFB1/var:C225R/Clv:1
Yes
organism-modification


PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human), hTGFB1/var:C225R/Clv:2
Yes
organism-sequence


PR:P01137-1 transforming growth factor beta-1 isoform 1 (human), hTGFB1/iso:1
Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
organism-modification


PR:000049430 transforming growth factor beta-1, signal peptide removed form (human), hTGFB1/SigPep-

organism-modification


PR:000021903 TGF-beta 1 sequence variant T81H, signal peptide removed form (human), hTGFB1/var:T81H/SigPep-

organism-modification


PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human), hTGFB1/var:T81H/Clv:1
Yes
organism-modification


PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human), hTGFB1/var:T81H/Clv:2
Yes
organism-modification


PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human), hTGFB1/var:R218C/SigPep-

organism-modification


PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human), hTGFB1/var:R218C/Clv:1
Yes
organism-modification


PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human), hTGFB1/var:R218C/Clv:2
Yes
organism-modification


PR:000021905 TGF-beta 1 sequence variant H222D, signal peptide removed form (human), hTGFB1/var:H222D/SigPep-

organism-modification


PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human), hTGFB1/var:H222D/Clv:1
Yes
organism-modification


PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human), hTGFB1/var:H222D/Clv:2
Yes
organism-modification


PR:000021906 TGF-beta 1 sequence variant C225R, signal peptide removed form (human), hTGFB1/var:C225R/SigPep-

organism-modification


PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human), hTGFB1/var:C225R/Clv:1
Yes
organism-modification


PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human), hTGFB1/var:C225R/Clv:2
Yes
organism-modification


PR:000021907 TGF-beta 1 sequence variant R218H, signal peptide removed form (human), hTGFB1/var:R218H/SigPep-

organism-modification


PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human), hTGFB1/var:R218H/Clv:1
Yes
organism-modification


PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human), hTGFB1/var:R218H/Clv:2
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
organism-modification


PR:000066327 transforming growth factor beta-1 deaminated 1 (human), hTGFB1/Deam:1

organism-modification


PR:000069562 transforming growth factor beta-1 cysteinylated 1 (human), hTGFB1/Cyst:1

organism-gene


PR:P04202 transforming growth factor beta-1 proprotein (mouse), mTGFB1

organism-sequence


PR:P04202-1 transforming growth factor beta-1 isoform 1 (mouse), mTGFB1/iso:1
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse), mTGFB1/iso:1/mature
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse), mTGFB1/iso:1/inactive
Yes
organism-gene


PR:P09533 transforming growth factor beta-1 (green monkey), GrMonkey-TGFB1

organism-sequence


PR:P09533-1 transforming growth factor beta-1 isoform 1 (green monkey), GrMonkey-TGFB1/iso:1

organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey), GrMonkey-TGFB1/iso:1/mature
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey), GrMonkey-TGFB1/iso:1/inactive
Yes
organism-gene


PR:P17246 transforming growth factor beta-1 (rat), rTGFB1

organism-modification


PR:000025929 TGF-beta 1 isoform 1 mature form (rat), rTGFB1/iso:1/mature
Yes
Yes
organism-gene


PR:Q9VQG9 dawdle, isoform A (fruit fly), fly-TGFB1

sequence


PR:000000397 TGF-beta 1 isoform 1, TGFB1/iso:1

organism-sequence


PR:P01137-1 transforming growth factor beta-1 isoform 1 (human), hTGFB1/iso:1
Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
organism-sequence


PR:P04202-1 transforming growth factor beta-1 isoform 1 (mouse), mTGFB1/iso:1
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse), mTGFB1/iso:1/mature
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse), mTGFB1/iso:1/inactive
Yes
organism-sequence


PR:P09533-1 transforming growth factor beta-1 isoform 1 (green monkey), GrMonkey-TGFB1/iso:1

organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey), GrMonkey-TGFB1/iso:1/mature
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey), GrMonkey-TGFB1/iso:1/inactive
Yes
modification


PR:000000616 TGF-beta 1 isoform 1 mature form, TGFB1/iso:1/mature

Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse), mTGFB1/iso:1/mature
Yes
organism-modification


PR:000025929 TGF-beta 1 isoform 1 mature form (rat), rTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey), GrMonkey-TGFB1/iso:1/mature
Yes
modification


PR:000002555 TGF-beta 1 isoform 1 unmodified form, TGFB1/iso:1/UnMod

modification


PR:000025454 TGF-beta 1 isoform 1, signal peptide removed form, TGFB1/iso:1/SigPep-

modification


PR:000000617 TGF-beta 1 isoform 1 latency associated peptide, TGFB1/iso:1/LAP

organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
modification


PR:000000618 TGF-beta 1 isoform 1 inactive form, TGFB1/iso:1/inactive

organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey), GrMonkey-TGFB1/iso:1/inactive
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse), mTGFB1/iso:1/inactive
Yes
modification


PR:000018291 TGF-beta 1, signal peptide removed form, TGFB1/SigPep-

modification


PR:000025454 TGF-beta 1 isoform 1, signal peptide removed form, TGFB1/iso:1/SigPep-

modification


PR:000000617 TGF-beta 1 isoform 1 latency associated peptide, TGFB1/iso:1/LAP

organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
modification


PR:000000618 TGF-beta 1 isoform 1 inactive form, TGFB1/iso:1/inactive

organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey), GrMonkey-TGFB1/iso:1/inactive
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse), mTGFB1/iso:1/inactive
Yes
organism-modification


PR:000049430 transforming growth factor beta-1, signal peptide removed form (human), hTGFB1/SigPep-

organism-modification


PR:000021903 TGF-beta 1 sequence variant T81H, signal peptide removed form (human), hTGFB1/var:T81H/SigPep-

organism-modification


PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human), hTGFB1/var:T81H/Clv:1
Yes
organism-modification


PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human), hTGFB1/var:T81H/Clv:2
Yes
organism-modification


PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human), hTGFB1/var:R218C/SigPep-

organism-modification


PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human), hTGFB1/var:R218C/Clv:1
Yes
organism-modification


PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human), hTGFB1/var:R218C/Clv:2
Yes
organism-modification


PR:000021905 TGF-beta 1 sequence variant H222D, signal peptide removed form (human), hTGFB1/var:H222D/SigPep-

organism-modification


PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human), hTGFB1/var:H222D/Clv:1
Yes
organism-modification


PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human), hTGFB1/var:H222D/Clv:2
Yes
organism-modification


PR:000021906 TGF-beta 1 sequence variant C225R, signal peptide removed form (human), hTGFB1/var:C225R/SigPep-

organism-modification


PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human), hTGFB1/var:C225R/Clv:1
Yes
organism-modification


PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human), hTGFB1/var:C225R/Clv:2
Yes
organism-modification


PR:000021907 TGF-beta 1 sequence variant R218H, signal peptide removed form (human), hTGFB1/var:R218H/SigPep-

organism-modification


PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human), hTGFB1/var:R218H/Clv:1
Yes
organism-modification


PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human), hTGFB1/var:R218H/Clv:2
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
modification


PR:000018292 TGF-beta 1 proteolytic cleavage product, TGFB1/ClvPrd

modification


PR:000000616 TGF-beta 1 isoform 1 mature form, TGFB1/iso:1/mature

Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse), mTGFB1/iso:1/mature
Yes
organism-modification


PR:000025929 TGF-beta 1 isoform 1 mature form (rat), rTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey), GrMonkey-TGFB1/iso:1/mature
Yes
modification


PR:000000617 TGF-beta 1 isoform 1 latency associated peptide, TGFB1/iso:1/LAP

organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
organism-modification


PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human), hTGFB1/var:T81H/Clv:1
Yes
organism-modification


PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human), hTGFB1/var:T81H/Clv:2
Yes
organism-modification


PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human), hTGFB1/var:R218C/Clv:1
Yes
organism-modification


PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human), hTGFB1/var:R218C/Clv:2
Yes
organism-modification


PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human), hTGFB1/var:H222D/Clv:1
Yes
organism-modification


PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human), hTGFB1/var:H222D/Clv:2
Yes
organism-modification


PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human), hTGFB1/var:C225R/Clv:1
Yes
organism-modification


PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human), hTGFB1/var:C225R/Clv:2
Yes
organism-modification


PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human), hTGFB1/var:R218H/Clv:1
Yes
organism-modification


PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human), hTGFB1/var:R218H/Clv:2
Yes
Back to top
TGFB1 forms found in complexes   

TGFB1 Component
 Complexes
PR:000000616 TGFB1/iso:1/mature PR:000025925
PR:000025927 hTGFB1/iso:1/mature PR:000025926
PR:000025929 rTGFB1/iso:1/mature PR:000025931
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000182
TGFB1
TGFB | TGF-beta-1		 acts_upstream_of_or_withinGO:0008283 cell population proliferation PANTHER:PTHR11848
GO:0030154 cell differentiation PANTHER:PTHR11848
PR:000000398
hTGFB1/var:L10P
UniProtKB:P01137, Leu-10, CHEBI:50342 | TGF-beta 1 sequence variant 1 (human)		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:9783545
PR:000000399
hTGFB1/var:T81H
UniProtKB:P01137, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 (human)		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463
associated_with_disease_progressionDO:4997 Camurati-Engelmann disease PMID:12493741
located_inSO:0001558 polypeptide_localization_variant PMID:11062463; PMID:12493741
PR:000000400
hTGFB1/var:R218C
UniProtKB:P01137, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 (human)		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12843182
GO:0043066 negative regulation of apoptotic process PMID:11062463; PMID:12493741; PMID:12843182
associated_with_disease_progressionDO:4997 Camurati-Engelmann disease PMID:10973241; PMID:11062463; PMID:12493741; PMID:12843182
enablesincreased GO:0008083 growth factor activity relative to PR:000002555 TGFB1/iso:1/UnMod PMID:11062463; PMID:12493741; PMID:12843182
PR:000000401
hTGFB1/var:R218H
UniProtKB:P01137, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 (human)		 associated_with_disease_progressionDO:4997 Camurati-Engelmann disease PMID:12493741
PR:000000402
hTGFB1/var:H222D
UniProtKB:P01137, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 (human)		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741
GO:0043066 negative regulation of apoptotic process PMID:12493741
associated_with_disease_progressionDO:4997 Camurati-Engelmann disease PMID:12493741
PR:000000403
hTGFB1/var:C225R
UniProtKB:P01137, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 (human)		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463; PMID:12493741; PMID:12843182
GO:0043066 negative regulation of apoptotic process PMID:11062463; PMID:12493741; PMID:12843182
associated_with_disease_progressionDO:4997 Camurati-Engelmann disease PMID:12493741
enablesincreased GO:0008083 growth factor activity relative to PR:000002555 TGFB1/iso:1/UnMod PMID:11062463; PMID:12493741; PMID:12843182
located_inGO:0005615 extracellular space PMID:11062463; PMID:12493741; PMID:12843182
PR:000000619
hTGFB1/var:T81H/Clv:1
UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 cleaved 1 (human)		 located_inSO:0001558 polypeptide_localization_variant PMID:12493741
PR:000000620
hTGFB1/var:T81H/Clv:2
UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 cleaved 2 (human)		 located_inGO:0005615 extracellular space PMID:12493741
PR:000000621
hTGFB1/var:R218C/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 1 (human)		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463; PMID:12493741; PMID:12843182
enablesGO:0005160 transforming growth factor beta receptor binding PMID:11278244
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:11062463; PMID:12493741; PMID:12843182
GO:0042803 protein homodimerization activity PMID:11062463; PMID:12493741; PMID:12843182
located_inGO:0005615 extracellular space PMID:11062463; PMID:12493741; PMID:12843182
PR:000000622
hTGFB1/var:R218C/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 2 (human)		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
PR:000000623
hTGFB1/var:H222D/Clv:1
UniProtKB:P01137, 279-390, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 cleaved 1 (human)		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741
GO:0043066 negative regulation of apoptotic process PMID:12493741
enablesincreased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:12493741
located_inGO:0005615 extracellular space PMID:12493741
PR:000000624
hTGFB1/var:H222D/Clv:2
UniProtKB:P01137, 30-278, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 cleaved 2 (human)		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
SO:0001601 conformational_change_variant PMID:11278244
PR:000000625
hTGFB1/var:C225R/Clv:1
UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 cleaved 1 (human)		 enablesincreased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:11062463; PMID:12493741; PMID:12843182
located_inGO:0005615 extracellular space PMID:11062463; PMID:12493741; PMID:12843182
PR:000000626
hTGFB1/var:C225R/Clv:2
UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 cleaved 2 (human)		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
PR:000000627
hTGFB1/var:R218H/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 cleaved 1 (human)		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11278244
enablesGO:0005160 transforming growth factor beta receptor binding PMID:11278244
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:12493741; PMID:12843182
GO:0042803 protein homodimerization activity PMID:11278244
located_inGO:0005615 extracellular space PMID:11278244
PR:000000628
hTGFB1/var:R218H/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 cleaved 2 (human)		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
SO:0001601 conformational_change_variant PMID:11278244
PR:000025927
hTGFB1/iso:1/mature
UniProtKB:P01137-1, 279-390 | PRO_0000033763		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8471846
GO:0043066 negative regulation of apoptotic process PMID:9918798
enablesGO:0042803 protein homodimerization activity PMID:3162913; PMID:8471846
located_inGO:0031012 extracellular matrix PMID:8294500
PR:000025928
mTGFB1/iso:1/mature
UniProtKB:P04202-1, 279-390 | PRO_0000033767		 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
enablesGO:0005160 transforming growth factor beta receptor binding PMID:14764882
located_inGO:0031012 extracellular matrix PMID:9008713
PR:000025929
rTGFB1/iso:1/mature
UniProtKB:P17246-1, 279-390 | PRO_0000033771		 located_inGO:0031012 extracellular matrix PMID:11907708
PR:000025930
GrMonkey-TGFB1/iso:1/mature
UniProtKB:P09533-1, 279-390 | PRO_0000033761		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3185545
enablesGO:0042803 protein homodimerization activity PMID:3185545
located_inGO:0031012 extracellular matrix PMID:3185545
PR:000026335
hTGFB1/iso:1/inactive
UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3162913
enablesNOT GO:0005160 transforming growth factor beta receptor binding PMID:2677679; PMID:3162913
GO:0042803 protein homodimerization activity PMID:3162913
located_inGO:0031012 extracellular matrix PMID:17015622; PMID:8294500
GO:0032991 protein-containing complex PMID:3162913
PR:000036526
hTGFB1/iso:1/LAP
UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160		 located_inGO:0032991 protein-containing complex PMID:17015622; PMID:3162913
PR:000036527
GrMonkey-TGFB1/iso:1/inactive
UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033760, PRO_0000033761, Asn-82, MOD:00160		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:1448117; PMID:2677679
enablesNOT GO:0005160 transforming growth factor beta receptor binding PMID:1448117
located_inGO:0032991 protein-containing complex PMID:1448117; PMID:2677679
PR:000036529
mTGFB1/iso:1/inactive
UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033766, PRO_0000033767, Asn-82, MOD:00160		 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
located_inGO:0031012 extracellular matrix PMID:9008713
PR:P01137-1
hTGFB1/iso:1
 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:1544940
GO:0043066 negative regulation of apoptotic process PMID:9918798
enablesGO:0042803 protein homodimerization activity PMID:1544940
located_inGO:0005796 Golgi lumen PMID:1544940
PR:P04202-1
mTGFB1/iso:1
 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856