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Protein Ontology report - fungal/metazoan cullin-1 isoform 1
PR:000000267 -
http://purl.obolibrary.org/obo/PR_000000267
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000267
PRO name
fungal/metazoan cullin-1 isoform 1
Synonyms
PRO-Short-label
:
EXACT:
CUL1/iso:1
Definition
"A fungal/metazoan cullin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by
UniProtKB:Q13616-1
or a 1:1 ortholog thereof." [PRO:CNA]
PRO Category
sequence
Parent
PR:000000092
fungal/metazoan cullin-1
Taxon
NCBITaxon:33154
Opisthokonta
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
1
Organism-Sequence
2
Modification
2
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
sequence
PR:000000267
fungal/metazoan cullin-1 isoform 1, CUL1/iso:1
organism-sequence
PR:Q13616-1
cullin-1 isoform 1 (human), hCUL1/iso:1
Yes
organism-modification
PR:000036454
cullin-1 isoform 1 neddylated 1 (human), hCUL1/iso:1/Nedd:1
Yes
organism-sequence
PR:Q9WTX6-1
cullin-1 isoform 1 (mouse), mCUL1/iso:1
modification
PR:000000427
fungal/metazoan cullin-1 isoform 1 neddylated form, CUL1/iso:1/NeddLys+
modification
PR:000000542
fungal/metazoan cullin-1 isoform 1 neddylated 1, CUL1/iso:1/Nedd:1
organism-modification
PR:000036454
cullin-1 isoform 1 neddylated 1 (human), hCUL1/iso:1/Nedd:1
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036454
hCUL1/iso:1/Nedd:1
UniProtKB:Q13616-1, Lys-720, MOD:01150
"A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]
acts_upstream_of_or_within
GO:0008285
negative regulation of cell population proliferation
PMID:8681378
GO:0031146
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
PMID:10713156
;
PMID:10921923
GO:0051726
regulation of cell cycle
PMID:8681378
GO:0097193
intrinsic apoptotic signaling pathway
PMID:8681378
located_in
GO:0019005
SCF ubiquitin ligase complex
PMID:10713156
;
PMID:10921923
;
PMID:17098746
PR:Q13616-1
hCUL1/iso:1
"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
enables
GO:0005515
protein binding
with
PR:P62877-1
PMID:12504026
;
PMID:15537541
GO:0005515
protein binding
with
PR:Q86VP6-1
PMID:12504026
;
PMID:15537541
located_in
NOT
GO:0019005
SCF ubiquitin ligase complex
PMID:10713156
;
PMID:10921923
;
PMID:12504026
