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Protein Ontology report - tumor necrosis factor ligand superfamily member 6 isoform FasL
PR:000000276 - http://purl.obolibrary.org/obo/PR_000000276
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000276   
  PRO nametumor necrosis factor ligand superfamily member 6 isoform FasL 
  Synonyms
PRO-Short-label: EXACT:FASLG/iso:FasL
Other: EXACT:tumor necrosis factor ligand superfamily member 6 isoform 1
RELATED:FasL long
  Definition"A tumor necrosis factor ligand superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48023-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000095 tumor necrosis factor ligand superfamily member 6
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence2                                                  Organism-Sequence 4                                        
         Modification3                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000276 tumor necrosis factor ligand superfamily member 6 isoform FasL, FASLG/iso:FasL

sequence


PR:000000278 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L, FASLG/iso:FasL/var:F273L

organism-sequence


PR:000036782 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human), hFASLG/iso:FasL/var:F273L
Yes
organism-sequence


PR:000036783 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse), mFASLG/iso:FasL/var:F273L
Yes
organism-sequence


PR:P41047-1 tumor necrosis factor ligand superfamily member 6 isoform FasL (mouse), mFASLG/iso:FasL
Yes
organism-sequence


PR:000036783 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse), mFASLG/iso:FasL/var:F273L
Yes
organism-sequence


PR:P48023-1 tumor necrosis factor ligand superfamily member 6 isoform FasL (human), hFASLG/iso:FasL
Yes
organism-sequence


PR:000036782 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human), hFASLG/iso:FasL/var:F273L
Yes
organism-modification


PR:000036458 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human), hFASLG/iso:FasL/NGlyco:1
Yes
organism-modification


PR:000036459 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human), hFASLG/iso:FasL/Clv:soluble
Yes
modification


PR:000000432 tumor necrosis factor ligand superfamily member 6 isoform FasL glycosylated form, FASLG/iso:FasL/GlycoRes+

modification


PR:000000546 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1, FASLG/iso:FasL/NGlyco:1

organism-modification


PR:000036458 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human), hFASLG/iso:FasL/NGlyco:1
Yes
modification


PR:000000547 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form, FASLG/iso:FasL/Clv:soluble

organism-modification


PR:000036459 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human), hFASLG/iso:FasL/Clv:soluble
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036458 hFASLG/iso:FasL/NGlyco:1
UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160
"A tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 in human. UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160." [PMID:9405425, PRO:CNA, PRO:DAN]		 acts_upstream_of_or_withinGO:0097190 apoptotic signaling pathway PMID:9405425
enablesGO:0005102 signaling receptor binding PMID:9405425
PR:000036459 hFASLG/iso:FasL/Clv:soluble
UniProtKB:P48023-1, 130-281 | PRO_0000034501
"A tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form in human. UniProtKB:P48023-1, 130-281." [PMID:7536672, PMID:9228058, PMID:9396774, PMID:9405425, PRO:CNA]		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:9396774
enablesGO:0005102 signaling receptor binding PMID:9405425
GO:0042802 identical protein binding PMID:7536672; PMID:9228058; PMID:9405425
located_inGO:0005615 extracellular space PMID:7536672
PR:000036782 hFASLG/iso:FasL/var:F273L
UniProtKB:P48023-1, Phe-275, CHEBI:30006 | FASLG isoform 1 sequence variant 1 (human) | FASLG isoform FasL sequence variant 1 (human) | tumor necrosis factor ligand superfamily member 6 isoform 1 sequence variant 1 (human) | tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant 1 (human) | gld
"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of human. The variation occurs at the position equivalent to Phe-275 of the amino acid sequence represented by UniProtKB:P48023-1. UniProtKB:P48023-1, Phe-275, CHEBI:30006." [PRO:DAN]		 enablesaltered GO:0005102 signaling receptor binding with PR:P25445 apo-1 antigen (human) PMID:9405425
GO:0042802 identical protein binding PMID:9405425
located_inGO:0009986 cell surface PMID:9405425
PR:000036783 mFASLG/iso:FasL/var:F273L
UniProtKB:P41047-1, Phe-273, CHEBI:30006 | Faslg isoform 1 sequence variant 1 (mouse) | Faslg isoform FasL sequence variant 1 (mouse) | tumor necrosis factor ligand superfamily member 6 isoform 1 sequence variant 1 (mouse) | tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant 1 (mouse) | gld
"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of mouse. The variation occurs at the position equivalent to Phe-273 of the amino acid sequence represented by UniProtKB:P41047-1. UniProtKB:P41047-1, Phe-273, CHEBI:30006." [PMID:7495745, PRO:DAN]		 associated_with_disease_progressionDO:6688 autoimmune lymphoproliferative syndrome PMID:7495745
located_inGO:0005886 plasma membrane PMID:7495745
PR:P41047-1 mFASLG/iso:FasL

"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of mouse." [PRO:CNA]		 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:16365167
GO:0043066 negative regulation of apoptotic process MGI:76989; PMID:7595210
GO:0097190 apoptotic signaling pathway PMID:15039234
located_inGO:0005886 plasma membrane PMID:16973387
GO:0009986 cell surface PMID:16973387
PR:P48023-1 hFASLG/iso:FasL
FASLG isoform 1 (human) | tumor necrosis factor ligand superfamily member 6 isoform 1 (human)
"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0043123 positive regulation of canonical NF-kappaB signal transduction PMID:12761501