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Protein Ontology report - Rho-associated protein kinase 1 isoform 1
PR:000000307 - http://purl.obolibrary.org/obo/PR_000000307
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000307   
  PRO nameRho-associated protein kinase 1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:ROCK1/iso:1
Other: EXACT:ROCK1 sequence 1
  Definition"A Rho-associated protein kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13464-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  CommentNote: In resting cells, the C-terminal Rho-binding and PH domain mask the protein kinase catalytic domain, activation occurs through a conformational change. 
  PRO Categorysequence 
  ParentPR:000000120 Rho-associated protein kinase 1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000307 Rho-associated protein kinase 1 isoform 1, ROCK1/iso:1

organism-sequence


PR:P70335-1 Rho-associated protein kinase 1 isoform 1 (mouse), mROCK1/iso:1

organism-modification


PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse), mROCK1/iso:1/Clv:1
Yes
organism-sequence


PR:Q13464-1 Rho-associated protein kinase 1 isoform 1 (human), hROCK1/iso:1
Yes
organism-modification


PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human), hROCK1/iso:1/Clv:1
Yes
organism-modification


PR:000044586 Rho-associated protein kinase 1 isoform 1 unmodified form (human), hROCK1/iso:1/UnMod
Yes
modification


PR:000000563 Rho-associated protein kinase 1 isoform 1 cleaved 1, ROCK1/iso:1/Clv:1

organism-modification


PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human), hROCK1/iso:1/Clv:1
Yes
organism-modification


PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse), mROCK1/iso:1/Clv:1
Yes
modification


PR:000002529 Rho-associated protein kinase 1 isoform 1 unmodified form, ROCK1/iso:1/UnMod

organism-modification


PR:000044586 Rho-associated protein kinase 1 isoform 1 unmodified form (human), hROCK1/iso:1/UnMod
Yes
modification


PR:000026574 Rho-associated protein kinase 1 isoform 1, initiator methionine removed form, ROCK1/iso:1/InitMet-

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026340 hROCK1/iso:1/Clv:1
UniProtKB:Q13464-1, 1-1113
"A Rho-associated protein kinase 1 isoform 1 cleaved 1 in human. UniProtKB:Q13464-1, 1-1113." [PRO:DNx, UniProtKB:Q13464]		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:11283607
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000002529 ROCK1/iso:1/UnMod PMID:11283607
PR:000036476 mROCK1/iso:1/Clv:1
UniProtKB:P70335-1, 1-1113
"A Rho-associated protein kinase 1 isoform 1 cleaved 1 in mouse. UniProtKB:P70335-1, 1-1113." [PMID:11283607, PMID:16983089, PRO:CNA]		 acts_upstream_of_or_withinGO:0010659 cardiac muscle cell apoptotic process PMID:16983089
GO:0030036 actin cytoskeleton organization PMID:11283607; PMID:16983089
PR:000044586 hROCK1/iso:1/UnMod

"A Rho-associated protein kinase 1 isoform 1 unmodified form in human." [PRO:DNx]		 enablesGO:0004674 protein serine/threonine kinase activity PMID:15699075
GO:0004674 protein serine/threonine kinase activity PMID:15699075
PR:Q13464-1 hROCK1/iso:1

"A Rho-associated protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:10436159
GO:0007266 Rho protein signal transduction PMID:8798490
GO:0030036 actin cytoskeleton organization PMID:10436159
GO:0051260 protein homooligomerization PMID:15291762
enablesGO:0004674 protein serine/threonine kinase activity PMID:8798490
GO:0031267 small GTPase binding PMID:14660612; PMID:15475352