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Protein Ontology report - TGF-beta 1 isoform 1
PR:000000397 - http://purl.obolibrary.org/obo/PR_000000397
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000397   
  PRO nameTGF-beta 1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:TGFB1/iso:1
  Definition"A TGF-beta 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01137-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000182 TGF-beta 1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 3                                        
         Modification5                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000397 TGF-beta 1 isoform 1, TGFB1/iso:1

organism-sequence


PR:P01137-1 transforming growth factor beta-1 isoform 1 (human), hTGFB1/iso:1
Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
organism-sequence


PR:P04202-1 transforming growth factor beta-1 isoform 1 (mouse), mTGFB1/iso:1
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse), mTGFB1/iso:1/mature
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse), mTGFB1/iso:1/inactive
Yes
organism-sequence


PR:P09533-1 transforming growth factor beta-1 isoform 1 (green monkey), GrMonkey-TGFB1/iso:1

organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey), GrMonkey-TGFB1/iso:1/mature
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey), GrMonkey-TGFB1/iso:1/inactive
Yes
modification


PR:000000616 TGF-beta 1 isoform 1 mature form, TGFB1/iso:1/mature

Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse), mTGFB1/iso:1/mature
Yes
organism-modification


PR:000025929 TGF-beta 1 isoform 1 mature form (rat), rTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey), GrMonkey-TGFB1/iso:1/mature
Yes
modification


PR:000002555 TGF-beta 1 isoform 1 unmodified form, TGFB1/iso:1/UnMod

modification


PR:000025454 TGF-beta 1 isoform 1, signal peptide removed form, TGFB1/iso:1/SigPep-

modification


PR:000000617 TGF-beta 1 isoform 1 latency associated peptide, TGFB1/iso:1/LAP

organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
modification


PR:000000618 TGF-beta 1 isoform 1 inactive form, TGFB1/iso:1/inactive

organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey), GrMonkey-TGFB1/iso:1/inactive
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse), mTGFB1/iso:1/inactive
Yes
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TGFB1/iso:1 forms found in complexes   

TGFB1/iso:1 Component
 Complexes
PR:000000616 TGFB1/iso:1/mature PR:000025925 dimeric TGF-beta 1
PR:000025927 hTGFB1/iso:1/mature PR:000025926 dimeric TGF-beta 1 (human)
PR:000025929 rTGFB1/iso:1/mature PR:000025931 dimeric TGF-beta 1 (rat)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025927 hTGFB1/iso:1/mature
UniProtKB:P01137-1, 279-390 | PRO_0000033763
"A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8471846
GO:0043066 negative regulation of apoptotic process PMID:9918798
enablesGO:0042803 protein homodimerization activity PMID:3162913; PMID:8471846
located_inGO:0031012 extracellular matrix PMID:8294500
PR:000025928 mTGFB1/iso:1/mature
UniProtKB:P04202-1, 279-390 | PRO_0000033767
"A TGF-beta 1 isoform 1 mature form in mouse. UniProtKB:P04202-1, 279-390." [PMID:2209468]		 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
enablesGO:0005160 transforming growth factor beta receptor binding PMID:14764882
located_inGO:0031012 extracellular matrix PMID:9008713
PR:000025929 rTGFB1/iso:1/mature
UniProtKB:P17246-1, 279-390 | PRO_0000033771
"A TGF-beta 1 isoform 1 mature form in rat. UniProtKB:P17246-1, 279-390." [PMID:11453552]		 located_inGO:0031012 extracellular matrix PMID:11907708
PR:000025930 GrMonkey-TGFB1/iso:1/mature
UniProtKB:P09533-1, 279-390 | PRO_0000033761
"A TGF-beta 1 isoform 1 mature form in green monkey. UniProtKB:P09533-1, 279-390." [PMID:3185545]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3185545
enablesGO:0042803 protein homodimerization activity PMID:3185545
located_inGO:0031012 extracellular matrix PMID:3185545
PR:000026335 hTGFB1/iso:1/inactive
UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3162913
enablesNOT GO:0005160 transforming growth factor beta receptor binding PMID:2677679; PMID:3162913
GO:0042803 protein homodimerization activity PMID:3162913
located_inGO:0031012 extracellular matrix PMID:17015622; PMID:8294500
GO:0032991 protein-containing complex PMID:3162913
PR:000036526 hTGFB1/iso:1/LAP
UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]		 located_inGO:0032991 protein-containing complex PMID:17015622; PMID:3162913
PR:000036527 GrMonkey-TGFB1/iso:1/inactive
UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033760, PRO_0000033761, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 inactive form in green monkey, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1448117, PMID:2677679, PRO:CNA, PRO:DAN]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:1448117; PMID:2677679
enablesNOT GO:0005160 transforming growth factor beta receptor binding PMID:1448117
located_inGO:0032991 protein-containing complex PMID:1448117; PMID:2677679
PR:000036529 mTGFB1/iso:1/inactive
UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033766, PRO_0000033767, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 inactive form in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1821856, PMID:9008713, PRO:CNA, PRO:DAN]		 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
located_inGO:0031012 extracellular matrix PMID:9008713
PR:P01137-1 hTGFB1/iso:1

"A TGF-beta 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:1544940
GO:0043066 negative regulation of apoptotic process PMID:9918798
enablesGO:0042803 protein homodimerization activity PMID:1544940
located_inGO:0005796 Golgi lumen PMID:1544940
PR:P04202-1 mTGFB1/iso:1

"A TGF-beta 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856