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Protein Ontology report - Rho-associated protein kinase 1 isoform 1 cleaved 1
PR:000000563 - http://purl.obolibrary.org/obo/PR_000000563
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000563   
  PRO nameRho-associated protein kinase 1 isoform 1 cleaved 1 
  Synonyms
PRO-Short-label: EXACT:ROCK1/iso:1/Clv:1
Other: EXACT:constitutively active ROCK-1
  Definition"A Rho-associated protein kinase 1 isoform 1 that has been processed by caspase-3 downstream the sequence motif DETD, removing the inhibitory C-terminus." [PMID:11283607, PMID:16983089
  CommentNote: This form has been found significantly elevated in mouse myopathy model and human heart failure patients. 
  PRO Categorymodification 
  ParentPR:000000307
PR:000025435
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
modification



PR:000000563 Rho-associated protein kinase 1 isoform 1 cleaved 1, ROCK1/iso:1/Clv:1


organism-modification



PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human), hROCK1/iso:1/Clv:1

Yes

organism-modification



PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse), mROCK1/iso:1/Clv:1

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026340
hROCK1/iso:1/Clv:1
UniProtKB:Q13464-1, 1-1113
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:11283607
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000002529 ROCK1/iso:1/UnMod PMID:11283607
PR:000036476
mROCK1/iso:1/Clv:1
UniProtKB:P70335-1, 1-1113
acts_upstream_of_or_withinGO:0010659 cardiac muscle cell apoptotic process PMID:16983089
GO:0030036 actin cytoskeleton organization PMID:11283607; PMID:16983089