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Protein Ontology report - smad2 isoform Short acetylated and phosphorylated 1
PR:000000655 -
http://purl.obolibrary.org/obo/PR_000000655
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000655
PRO name
smad2 isoform Short acetylated and phosphorylated 1
Synonyms
PRO-Short-label
:
EXACT:
SMAD2/iso:Short/AcPhos:1
Definition
"A smad2 isoform Short acetylated and phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation and acetylated in a Lys residue within the MH1 domain by coactivators, such as CBP, PCAF and EP300. Example:
UniProtKB:Q15796-2
, Lys-19,
MOD:00064
|Ser-435/Ser-437,
MOD:00046
." [
PMID:17074756
]
PRO Category
modification
Parent
PR:000000575
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000000655
smad2 isoform Short acetylated and phosphorylated 1, SMAD2/iso:Short/AcPhos:1
organism-modification
PR:000036556
smad2 isoform Short acetylated and phosphorylated 1 (human), hSMAD2/iso:Short/AcPhos:1
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036556
hSMAD2/iso:Short/AcPhos:1
UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:17074756
enables
GO:0003677
DNA binding
PMID:17074756
increased
GO:0003700
DNA-binding transcription factor activity
relative to
PR:000000656
SMAD2/iso:Short/Phos:1
PMID:17074756
