back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - transient receptor potential cation channel TRPC
PR:000000680 - http://purl.obolibrary.org/obo/PR_000000680
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000680   
  PRO nametransient receptor potential cation channel TRPC 
  Synonyms
PRO-Short-label: EXACT:fam:TRPC
  Definition"A transient receptor potential channel protein that is a member of the subfamily C of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains up to 4 detectable copies of Ankyrin repeat (Pfam:PF00023) followed by the Transient receptor ion channel II domain (Pfam:PF08344). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means." [PMID:16382100, PMID:16460286, PMID:17579562, PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000044657
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family3                                                  Organism-Family 0                                        
         Gene7                                                  Organism-Gene 17                                        
         Sequence12                                                  Organism-Sequence 31                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF005528
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000680 transient receptor potential cation channel TRPC, fam:TRPC

family


PR:000000718 transient receptor potential cation channel TRPC3/6/7, fam:TRPC[3/6/7]

gene


PR:000000775 short transient receptor potential cation channel TRPC3, TRPC3

organism-gene


PR:P34586 transient-receptor-potential-like protein (worm), TRPC3 (worm)

organism-gene


PR:Q13507 short transient receptor potential channel 3 (human), hTRPC3

organism-sequence


PR:Q13507-1 short transient receptor potential channel 3 isoform 1 (human), hTRPC3/iso:1
Yes
organism-sequence


PR:Q13507-2 short transient receptor potential channel 3 isoform h1 (human), hTRPC3/iso:h1

organism-sequence


PR:Q13507-3 short transient receptor potential channel 3 isoform h2 (human), hTRPC3/iso:h2

organism-gene


PR:Q9JMI9 short transient receptor potential channel 3 (rat), rTRPC3

organism-gene


PR:Q9QZC1 short transient receptor potential channel 3 (mouse), mTRPC3

sequence


PR:000000937 short transient receptor potential cation channel TRPC3 isoform 1, TRPC3/iso:1

organism-sequence


PR:Q13507-1 short transient receptor potential channel 3 isoform 1 (human), hTRPC3/iso:1
Yes
gene


PR:000001080 short transient receptor potential cation channel TRPC7, TRPC7

organism-gene


PR:Q9HCX4 short transient receptor potential channel 7 (human), hTRPC7
Yes
organism-sequence


PR:Q9HCX4-1 short transient receptor potential channel 7 isoform 1 (human), hTRPC7/iso:1

organism-sequence


PR:Q9HCX4-2 short transient receptor potential channel 7 isoform h2 (human), hTRPC7/iso:h2

organism-sequence


PR:Q9HCX4-3 short transient receptor potential channel 7 isoform h3 (human), hTRPC7/iso:h3

organism-gene


PR:Q9WVC5 short transient receptor potential channel 7 (mouse), mTRPC7

organism-sequence


PR:Q9WVC5-1 short transient receptor potential channel 7 isoform 1 (mouse), mTRPC7/iso:1
Yes
sequence


PR:000001081 short transient receptor potential cation channel TRPC7 isoform 1, TRPC7/iso:1

organism-sequence


PR:Q9HCX4-1 short transient receptor potential channel 7 isoform 1 (human), hTRPC7/iso:1

organism-sequence


PR:Q9WVC5-1 short transient receptor potential channel 7 isoform 1 (mouse), mTRPC7/iso:1
Yes
gene


PR:000016696 short transient receptor potential channel 6, TRPC6

organism-gene


PR:Q61143 short transient receptor potential channel 6 (mouse), mTRPC6

organism-gene


PR:Q9Y210 short transient receptor potential channel 6 (human), hTRPC6

organism-sequence


PR:Q9Y210-1 short transient receptor potential channel 6 isoform h1 (human), hTRPC6/iso:h1

organism-sequence


PR:Q9Y210-2 short transient receptor potential channel 6 isoform h2 (human), hTRPC6/iso:h2

organism-sequence


PR:Q9Y210-3 short transient receptor potential channel 6 isoform h3 (human), hTRPC6/iso:h3

organism-modification


PR:000058350 short transient receptor potential channel 6 N-glycosylated 1 (human), hTRPC6/NGlyco:1

organism-modification


PR:000058351 short transient receptor potential channel 6 N-glycosylated 2 (human), hTRPC6/NGlyco:2

organism-modification


PR:000072935 short transient receptor potential channel 6 phosphorylated 1 (human), hTRPC6/Phos:1

family


PR:000001074 transient receptor potential cation channel TRPC with PDZ-binding motif, TRPV4/iso:E

gene


PR:000001075 short transient receptor potential cation channel TRPC4, TRPC4

organism-gene


PR:O35119 short transient receptor potential channel 4 (rat), rTRPC4

organism-sequence


PR:O35119-1 short transient receptor potential channel 4 isoform alpha (rat), rTRPC4/iso:Alpha

organism-sequence


PR:O35119-2 short transient receptor potential channel 4 isoform beta (rat), rTRPC4/iso:Beta

organism-gene


PR:Q9QUQ5 short transient receptor potential channel 4 (mouse), mTRPC4
Yes
organism-sequence


PR:Q9QUQ5-1 short transient receptor potential channel 4 isoform alpha (mouse), mTRPC4/iso:Alpha
Yes
organism-sequence


PR:Q9QUQ5-2 short transient receptor potential channel 4 isoform beta (mouse), mTRPC4/iso:Beta

organism-gene


PR:Q9UBN4 short transient receptor potential channel 4 (human), hTRPC4

organism-sequence


PR:Q9UBN4-1 short transient receptor potential channel 4 isoform alpha (human), hTRPC4/iso:Alpha
Yes
organism-sequence


PR:Q9UBN4-2 short transient receptor potential channel 4 isoform beta (human), hTRPC4/iso:Beta
Yes
organism-sequence


PR:Q9UBN4-3 short transient receptor potential channel 4 isoform delta (human), hTRPC4/iso:Delta

organism-sequence


PR:Q9UBN4-4 short transient receptor potential channel 4 isoform gamma (human), hTRPC4/iso:Gamma

organism-sequence


PR:Q9UBN4-5 short transient receptor potential channel 4 isoform Epsilon (human), hTRPC4/iso:Epsilon

organism-sequence


PR:Q9UBN4-6 short transient receptor potential channel 4 isoform Zeta (human), hTRPC4/iso:Zeta

organism-sequence


PR:Q9UBN4-7 short transient receptor potential channel 4 isoform Eta (human), hTRPC4/iso:Eta

sequence


PR:000001076 short transient receptor potential cation channel TRPC4 isoform 1, TRPC4/iso:1

organism-sequence


PR:O35119-1 short transient receptor potential channel 4 isoform alpha (rat), rTRPC4/iso:Alpha

organism-sequence


PR:Q9QUQ5-1 short transient receptor potential channel 4 isoform alpha (mouse), mTRPC4/iso:Alpha
Yes
organism-sequence


PR:Q9UBN4-1 short transient receptor potential channel 4 isoform alpha (human), hTRPC4/iso:Alpha
Yes
sequence


PR:000001077 short transient receptor potential cation channel TRPC4 isoform 2, TRPC4/iso:2

organism-sequence


PR:O35119-2 short transient receptor potential channel 4 isoform beta (rat), rTRPC4/iso:Beta

organism-sequence


PR:Q9QUQ5-2 short transient receptor potential channel 4 isoform beta (mouse), mTRPC4/iso:Beta

organism-sequence


PR:Q9UBN4-2 short transient receptor potential channel 4 isoform beta (human), hTRPC4/iso:Beta
Yes
sequence


PR:000001078 short transient receptor potential cation channel TRPC4 isoform 3, TRPC4/iso:3

organism-sequence


PR:Q9UBN4-3 short transient receptor potential channel 4 isoform delta (human), hTRPC4/iso:Delta

sequence


PR:000001079 short transient receptor potential cation channel TRPC4 isoform 4, TRPC4/iso:4

organism-sequence


PR:Q9UBN4-4 short transient receptor potential channel 4 isoform gamma (human), hTRPC4/iso:Gamma

gene


PR:000001725 short transient receptor potential cation channel TRPC2, Trpc2

organism-gene


PR:Q9R244 short transient receptor potential channel 2 (mouse), mTrpc2
Yes
organism-sequence


PR:Q9R244-1 short transient receptor potential channel 2 isoform 1 (mouse), mTrpc2/iso:1
Yes
organism-sequence


PR:Q9R244-2 short transient receptor potential channel 2 isoform 2 (mouse), mTrpc2/iso:2
Yes
organism-sequence


PR:Q9R244-3 short transient receptor potential channel 2 isoform 3 (mouse), mTrpc2/iso:3
Yes
organism-sequence


PR:Q9R244-4 short transient receptor potential channel 2 isoform 4 (mouse), mTrpc2/iso:4
Yes
sequence


PR:000001726 short transient receptor potential cation channel TRPC2 isoform 1, Trpc2/iso:1

organism-sequence


PR:Q9R244-1 short transient receptor potential channel 2 isoform 1 (mouse), mTrpc2/iso:1
Yes
sequence


PR:000001727 short transient receptor potential cation channel TRPC2 isoform 2, Trpc2/iso:2

organism-sequence


PR:Q9R244-2 short transient receptor potential channel 2 isoform 2 (mouse), mTrpc2/iso:2
Yes
sequence


PR:000001728 short transient receptor potential cation channel TRPC2 isoform 3, Trpc2/iso:3

organism-sequence


PR:Q9R244-3 short transient receptor potential channel 2 isoform 3 (mouse), mTrpc2/iso:3
Yes
sequence


PR:000001729 short transient receptor potential cation channel TRPC2 isoform 4, Trpc2/iso:4

organism-sequence


PR:Q9R244-4 short transient receptor potential channel 2 isoform 4 (mouse), mTrpc2/iso:4
Yes
gene


PR:000016693 short transient receptor potential channel 1, TRPC1

organism-gene


PR:P48995 short transient receptor potential channel 1 (human), hTRPC1

organism-sequence


PR:P48995-1 short transient receptor potential channel 1 isoform Long (human), hTRPC1/iso:Long

organism-sequence


PR:P48995-2 short transient receptor potential channel 1 isoform Short (human), hTRPC1/iso:Short

organism-gene


PR:Q61056 short transient receptor potential channel 1 (mouse), mTRPC1

organism-sequence


PR:Q61056-1 short transient receptor potential channel 1 isoform Alpha (mouse), mTRPC1/iso:Alpha

organism-sequence


PR:Q61056-2 short transient receptor potential channel 1 isoform Beta (mouse), mTRPC1/iso:Beta

organism-gene


PR:Q9QX01 short transient receptor potential channel 1 (rat), rTRPC1

organism-sequence


PR:Q9QX01-1 short transient receptor potential channel 1 isoform Beta (rat), rTRPC1/iso:Beta

organism-sequence


PR:Q9QX01-2 short transient receptor potential channel 1 isoform Alpha (rat), rTRPC1/iso:Alpha

sequence


PR:000039570 short transient receptor potential channel 1 isoform 1, TRPC1/iso:1

organism-sequence


PR:P48995-1 short transient receptor potential channel 1 isoform Long (human), hTRPC1/iso:Long

organism-sequence


PR:Q61056-1 short transient receptor potential channel 1 isoform Alpha (mouse), mTRPC1/iso:Alpha

sequence


PR:000039571 short transient receptor potential channel 1 isoform 2, TRPC1/iso:2

organism-sequence


PR:P48995-2 short transient receptor potential channel 1 isoform Short (human), hTRPC1/iso:Short

organism-sequence


PR:Q61056-2 short transient receptor potential channel 1 isoform Beta (mouse), mTRPC1/iso:Beta

gene


PR:000016695 short transient receptor potential channel 5, TRPC5

organism-gene


PR:Q9QX29 short transient receptor potential channel 5 (mouse), mTRPC5

organism-gene


PR:Q9UL62 short transient receptor potential channel 5 (human), hTRPC5

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q13507-1
hTRPC3/iso:1
 acts_upstream_of_or_withinGO:0007602 phototransduction PMID:9215637
enablesGO:0005515 protein binding PMID:15744307
GO:0015279 store-operated calcium channel activity PMID:9215637
located_inGO:0005886 plasma membrane PMID:9368034
PR:Q9HCX4
hTRPC7
TRP7 | TRPC7 | hTRP7 | transient receptor protein 7 (human) | TRP-7 (human) | TrpC7 (human) (BROAD)		 enablesGO:0005515 protein binding with PR:P20591 hMX1 PMID:15757897
PR:Q9QUQ5
mTRPC4
Trpc4 | Trrp4 | capacitative calcium entry channel Trp4 (mouse) | receptor-activated cation channel TRP4 (mouse) | TrpC4 (mouse)		 acts_upstream_of_or_withinGO:0014051 gamma-aminobutyric acid secretion PMID:14668438
located_inGO:0005901 caveola PMID:11897792
PR:Q9QUQ5-1
mTRPC4/iso:Alpha
 enablesGO:0015279 store-operated calcium channel activity MGI:3525810; PMID:15044151
located_inGO:0005886 plasma membrane MGI:3525810; PMID:15044151
PR:Q9R244
mTrpc2
Trp2 | Trpc2 | Trrp2 | mTrp2 | transient receptor protein 2 (mouse) | TRP-2 (mouse) | TrpC2 (mouse)		 acts_upstream_of_or_withinNOT GO:0015279 store-operated calcium channel activity PMID:10998353
PR:Q9R244-1
mTrpc2/iso:1
short transient receptor potential channel 2 isoform A (mouse)		 enablesGO:0005516 calmodulin binding MGI:2652910; PMID:12601176
PR:Q9R244-2
mTrpc2/iso:2
short transient receptor potential channel 2 isoform B (mouse)		 enablesGO:0005516 calmodulin binding PMID:12601176
PR:Q9R244-3
mTrpc2/iso:3
short transient receptor potential channel 2 isoform Alpha (mouse)		 located_inGO:0000139 Golgi membrane MGI:1913270; PMID:10998353
GO:0005635 nuclear envelope MGI:1913270; PMID:10998353
GO:0005789 endoplasmic reticulum membrane MGI:1913270; PMID:10998353
PR:Q9R244-4
mTrpc2/iso:4
short transient receptor potential channel 2 isoform Beta (mouse)		 located_inGO:0000139 Golgi membrane PMID:10998353
GO:0005635 nuclear envelope MGI:1913270; PMID:10998353
GO:0005789 endoplasmic reticulum membrane MGI:1913270; PMID:10998353
PR:Q9UBN4-1
hTRPC4/iso:Alpha
 enablescontributes_to GO:0015279 store-operated calcium channel activity PMID:11713258
GO:0042802 identical protein binding PMID:11713258
located_inGO:0005886 plasma membrane PMID:11713258
PR:Q9UBN4-2
hTRPC4/iso:Beta
 enablescontributes_to GO:0015279 store-operated calcium channel activity PMID:11713258
GO:0042802 identical protein binding PMID:11713258
located_inGO:0005886 plasma membrane PMID:11713258
PR:Q9WVC5-1
mTRPC7/iso:1
 acts_upstream_of_or_withinGO:0006816 calcium ion transport PMID:10488066
enablescontributes_to GO:0005262 calcium channel activity PMID:10488066
contributes_to GO:0006828 manganese ion transport PMID:10488066
located_inGO:0016020 membrane PMID:10488066