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Protein Ontology report - CD34 molecule
PR:000001003 - http://purl.obolibrary.org/obo/PR_000001003
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000001003   
  PRO nameCD34 molecule 
  Synonyms
PRO-Short-label: EXACT:CD34
Other: EXACT:hematopoietic progenitor cell antigen CD34
  Definition"A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved." [PMID:16720896, PMID:8983065] 
  CommentRequested by=CL. 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification1                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF028749
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001003 CD34 molecule, CD34

organism-gene


PR:P28906 hematopoietic progenitor cell antigen CD34 (human), hCD34

organism-sequence


PR:P28906-1 hematopoietic progenitor cell antigen CD34 isoform hCD34-F (human), hCD34/iso:hCD34-F

organism-modification


PR:000060688 hematopoietic progenitor cell antigen CD34 isoform hCD34-F, signal peptide removed form (human), hCD34/iso:hCD34-F/SigPep-

organism-sequence


PR:P28906-2 hematopoietic progenitor cell antigen CD34 isoform hCD34-T (human), hCD34/iso:hCD34-T

organism-modification


PR:000056324 hematopoietic progenitor cell antigen CD34 O-glycosylated 1 (human), hCD34/OGlyco:1

organism-modification


PR:000056325 hematopoietic progenitor cell antigen CD34 O-glycosylated 2 (human), hCD34/OGlyco:2

organism-gene


PR:Q64314 hematopoietic progenitor cell antigen CD34 (mouse), mCD34

organism-sequence


PR:Q64314-1 hematopoietic progenitor cell antigen CD34 isoform Long (mouse), mCD34/iso:Long

organism-sequence


PR:Q64314-2 hematopoietic progenitor cell antigen CD34 isoform Short (mouse), mCD34/iso:Short

modification


PR:000018302 CD34 molecule, signal peptide removed form, CD34/SigPep-