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Protein Ontology report - erm protein
PR:000001030 - http://purl.obolibrary.org/obo/PR_000001030
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000001030   
  PRO nameerm protein 
  Definition"A protein that contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain, and a charged C-terminal domain. Ezrin, radixin and merlin also contain a polyproline region between the helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily. ERM proteins are involved in crosslinking actin filaments with plasma membranes." [InterPro:IPR011259] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 14                                        
         Sequence7                                                  Organism-Sequence 29                                        
         Modification20                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF002305
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000001030 erm protein, CD247/iso:CD3 zeta
Yes
gene


PR:000001031 ezrin, EZR

organism-gene


PR:P15311 ezrin (human), hEZR

organism-sequence


PR:P15311-1 ezrin isoform 1 (human), hEZR/iso:1

organism-modification


PR:000036588 ezrin isoform 1 phosphorylated 1 (human), hEZR/iso:1/Phos:1

organism-modification


PR:000036589 ezrin isoform 1 phosphorylated 2 (human), hEZR/iso:1/Phos:2
Yes
organism-modification


PR:000036590 ezrin isoform 1 phosphorylated 3 (human), hEZR/iso:1/Phos:3
Yes
organism-modification


PR:000036591 ezrin isoform 1 phosphorylated 4 (human), hEZR/iso:1/Phos:4

organism-modification


PR:000036592 ezrin isoform 1 phosphorylated 5 (human), hEZR/iso:1/Phos:5
Yes
organism-modification


PR:000036625 ezrin isoform 1 phosphorylated 6 (human), hEZR/iso:1/Phos:6
Yes
organism-modification


PR:000047345 ezrin, initiator methionine removed phosphorylated 5 (human), hEZR/InitMet-/Phos:5

organism-modification


PR:000047346 ezrin, initiator methionine removed phosphorylated 1 (human), hEZR/InitMet-/Phos:1

organism-gene


PR:P26040 ezrin (mouse), mEZR

organism-sequence


PR:P26040-1 ezrin isoform 1 (mouse), mEZR/iso:1

organism-modification


PR:000044790 ezrin isoform 1 phosphorylated 5 (mouse), mEZR/iso:1/Phos:5

organism-gene


PR:P31977 ezrin (rat), rEZR

organism-sequence


PR:P31977-1 ezrin isoform 1 (rat), rEZR/iso:1

organism-gene


PR:P46150 moesin/ezrin/radixin homolog 1 (fruit fly), fly-EZR

organism-sequence


PR:P46150-1 moesin/ezrin/radixin homolog 1 isoform J (fruit fly), fly-EZR/iso:J

organism-sequence


PR:P46150-2 moesin/ezrin/radixin homolog 1 isoform D (fruit fly), fly-EZR/iso:D

organism-sequence


PR:P46150-3 moesin/ezrin/radixin homolog 1 isoform A (fruit fly), fly-EZR/iso:A

organism-sequence


PR:P46150-4 moesin/ezrin/radixin homolog 1 isoform B (fruit fly), fly-EZR/iso:B

organism-sequence


PR:P46150-5 moesin/ezrin/radixin homolog 1 isoform C (fruit fly), fly-EZR/iso:C

sequence


PR:000001032 ezrin isoform 1, EZR/iso:1

organism-sequence


PR:P15311-1 ezrin isoform 1 (human), hEZR/iso:1

organism-modification


PR:000036588 ezrin isoform 1 phosphorylated 1 (human), hEZR/iso:1/Phos:1

organism-modification


PR:000036589 ezrin isoform 1 phosphorylated 2 (human), hEZR/iso:1/Phos:2
Yes
organism-modification


PR:000036590 ezrin isoform 1 phosphorylated 3 (human), hEZR/iso:1/Phos:3
Yes
organism-modification


PR:000036591 ezrin isoform 1 phosphorylated 4 (human), hEZR/iso:1/Phos:4

organism-modification


PR:000036592 ezrin isoform 1 phosphorylated 5 (human), hEZR/iso:1/Phos:5
Yes
organism-modification


PR:000036625 ezrin isoform 1 phosphorylated 6 (human), hEZR/iso:1/Phos:6
Yes
organism-sequence


PR:P26040-1 ezrin isoform 1 (mouse), mEZR/iso:1

organism-modification


PR:000044790 ezrin isoform 1 phosphorylated 5 (mouse), mEZR/iso:1/Phos:5

organism-sequence


PR:P31977-1 ezrin isoform 1 (rat), rEZR/iso:1

modification


PR:000001033 ezrin isoform 1 phosphorylated form, EZR/iso:1/PhosRes+

modification


PR:000001034 ezrin isoform 1 phosphorylated 1, EZR/iso:1/Phos:1

organism-modification


PR:000036588 ezrin isoform 1 phosphorylated 1 (human), hEZR/iso:1/Phos:1

modification


PR:000001035 ezrin isoform 1 phosphorylated 2, EZR/iso:1/Phos:2

organism-modification


PR:000036589 ezrin isoform 1 phosphorylated 2 (human), hEZR/iso:1/Phos:2
Yes
modification


PR:000001038 ezrin isoform 1 phosphorylated 3, EZR/iso:1/Phos:3

organism-modification


PR:000036590 ezrin isoform 1 phosphorylated 3 (human), hEZR/iso:1/Phos:3
Yes
modification


PR:000001039 ezrin isoform 1 phosphorylated 4, EZR/iso:1/Phos:4

organism-modification


PR:000036591 ezrin isoform 1 phosphorylated 4 (human), hEZR/iso:1/Phos:4

modification


PR:000001040 ezrin isoform 1 phosphorylated 5, EZR/iso:1/Phos:5

organism-modification


PR:000036592 ezrin isoform 1 phosphorylated 5 (human), hEZR/iso:1/Phos:5
Yes
organism-modification


PR:000044790 ezrin isoform 1 phosphorylated 5 (mouse), mEZR/iso:1/Phos:5

modification


PR:000003042 ezrin isoform 1 phosphorylated 6, EZR/iso:1/Phos:6

organism-modification


PR:000036625 ezrin isoform 1 phosphorylated 6 (human), hEZR/iso:1/Phos:6
Yes
modification


PR:000026720 ezrin isoform 1, initiator methionine removed form, EZR/iso:1/InitMet-

modification


PR:000018330 ezrin, initiator methionine removed form, EZR/InitMet-

modification


PR:000026720 ezrin isoform 1, initiator methionine removed form, EZR/iso:1/InitMet-

organism-modification


PR:000047345 ezrin, initiator methionine removed phosphorylated 5 (human), hEZR/InitMet-/Phos:5

organism-modification


PR:000047346 ezrin, initiator methionine removed phosphorylated 1 (human), hEZR/InitMet-/Phos:1

gene


PR:000003008 moesin, MSN

organism-gene


PR:O35763 moesin (rat), rMSN

organism-gene


PR:P26038 moesin (human), hMSN

organism-sequence


PR:P26038-1 moesin isoform 1 (human), hMSN/iso:1

organism-modification


PR:000036621 moesin isoform 1 phosphorylated 1 (human), hMSN/iso:1/Phos:1
Yes
organism-modification


PR:000048458 moesin, initiator methionine removed form (human), hMSN/InitMet-

organism-modification


PR:000061816 moesin, initiator methionine removed phosphorylated 1 (human), hMSN/InitMet-/Phos:1

organism-modification


PR:000070075 moesin methylated 1 (human), hMSN/Me:1

organism-gene


PR:P26041 moesin (mouse), mMSN

organism-sequence


PR:P26041-1 moesin isoform 1 (mouse), mMSN/iso:1

sequence


PR:000003010 moesin isoform 1, MSN/iso:1

organism-sequence


PR:P26038-1 moesin isoform 1 (human), hMSN/iso:1

organism-modification


PR:000036621 moesin isoform 1 phosphorylated 1 (human), hMSN/iso:1/Phos:1
Yes
organism-sequence


PR:P26041-1 moesin isoform 1 (mouse), mMSN/iso:1

organism-sequence


PR:P26044-1 radixin isoform 1 (pig), pig-MSN/iso:1

modification


PR:000003012 moesin isoform 1 phosphorylated form, MSN/iso:1/PhosRes+

modification


PR:000003013 moesin isoform 1 phosphorylated 1, MSN/iso:1/Phos:1

organism-modification


PR:000036621 moesin isoform 1 phosphorylated 1 (human), hMSN/iso:1/Phos:1
Yes
modification


PR:000026668 moesin isoform 1, initiator methionine removed form, MSN/iso:1/InitMet-

modification


PR:000018777 moesin, initiator methionine removed form, MSN/InitMet-

modification


PR:000026668 moesin isoform 1, initiator methionine removed form, MSN/iso:1/InitMet-

organism-modification


PR:000048458 moesin, initiator methionine removed form (human), hMSN/InitMet-

gene


PR:000003009 radixin, RDX

organism-gene


PR:P26043 radixin (mouse), mRDX

organism-sequence


PR:P26043-1 radixin isoform 1 (mouse), mRDX/iso:1

organism-gene


PR:P26044 radixin (pig), pig-RDX

organism-gene


PR:P35241 radixin (human), hRDX

organism-sequence


PR:P35241-1 radixin isoform 1 (human), hRDX/iso:1

organism-sequence


PR:P35241-2 radixin isoform h2 (human), hRDX/iso:h2

organism-sequence


PR:P35241-3 radixin isoform h3 (human), hRDX/iso:h3

organism-sequence


PR:P35241-4 radixin isoform h4 (human), hRDX/iso:h4

organism-sequence


PR:P35241-5 radixin isoform h5 (human), hRDX/iso:h5

organism-modification


PR:000062353 radixin phosphorylated 1 (human), hRDX/Phos:1

organism-modification


PR:000068068 radixin deaminated 1 (human), hRDX/Deam:1

organism-gene


PR:Q9PU45 radixin (chicken), chick-RDX

sequence


PR:000003014 radixin isoform 1, RDX/iso:1

organism-sequence


PR:P26043-1 radixin isoform 1 (mouse), mRDX/iso:1

organism-sequence


PR:P35241-1 radixin isoform 1 (human), hRDX/iso:1

modification


PR:000003049 radixin isoform 1 phosphorylated form, RDX/iso:1/PhosRes+

modification


PR:000003050 radixin isoform 1 phosphorylated 1, RDX/iso:1/Phos:1

gene


PR:000003020 merlin, NF2

organism-gene


PR:P35240 merlin (human), hNF2

organism-sequence


PR:P35240-1 merlin isoform 1 (human), hNF2/iso:1
Yes
organism-sequence


PR:P35240-10 merlin isoform h10 (human), hNF2/iso:h10

organism-sequence


PR:P35240-2 merlin isoform 3 (human), hNF2/iso:3

organism-sequence


PR:P35240-3 merlin isoform 2 (human), hNF2/iso:2
Yes
organism-sequence


PR:P35240-4 merlin isoform 4 (human), hNF2/iso:4
Yes
organism-sequence


PR:P35240-5 merlin isoform h5 (human), hNF2/iso:h5

organism-sequence


PR:P35240-6 merlin isoform h6 (human), hNF2/iso:h6

organism-sequence


PR:P35240-7 merlin isoform h7 (human), hNF2/iso:h7

organism-sequence


PR:P35240-8 merlin isoform h8 (human), hNF2/iso:h8

organism-sequence


PR:P35240-9 merlin isoform h9 (human), hNF2/iso:h9

organism-modification


PR:000045760 merlin phosphorylated 1 (human), hNF2/Phos:1

organism-modification


PR:000080467 merlin methylated 1 (human), hNF2/Me:1

organism-gene


PR:P46662 merlin (mouse), mNF2

organism-sequence


PR:P46662-1 merlin isoform 1 (mouse), mNF2/iso:1

organism-sequence


PR:P46662-2 merlin isoform 2 (mouse), mNF2/iso:2

organism-gene


PR:Q24564 moesin/ezrin/radixin homolog 2 (fruit fly), fly-NF2

sequence


PR:000003021 merlin isoform 1, NF2/iso:1

organism-sequence


PR:P35240-1 merlin isoform 1 (human), hNF2/iso:1
Yes
organism-sequence


PR:P46662-1 merlin isoform 1 (mouse), mNF2/iso:1

modification


PR:000003024 merlin isoform 1 phosphorylated form, NF2/iso:1/PhosRes+

modification


PR:000003025 merlin isoform 1 phosphorylated 1, NF2/iso:1/Phos:1

modification


PR:000003026 merlin isoform 1 phosphorylated 2, NF2/iso:1/Phos:2

sequence


PR:000003022 merlin isoform 2, NF2/iso:2

organism-sequence


PR:P35240-3 merlin isoform 2 (human), hNF2/iso:2
Yes
organism-sequence


PR:P46662-2 merlin isoform 2 (mouse), mNF2/iso:2

modification


PR:000003028 merlin isoform 2 phosphorylated form, NF2/iso:2/PhosRes+

modification


PR:000003029 merlin isoform 2 phosphorylated 1, NF2/iso:2/Phos:1

sequence


PR:000026545 merlin isoform 3, NF2/iso:3

organism-sequence


PR:P35240-2 merlin isoform 3 (human), hNF2/iso:3

sequence


PR:000026547 merlin isoform 4, NF2/iso:4

organism-sequence


PR:P35240-4 merlin isoform 4 (human), hNF2/iso:4
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000001030 CD247/iso:CD3 zeta

"A protein that contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain, and a charged C-terminal domain. Ezrin, radixin and merlin also contain a polyproline region between the helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily. ERM proteins are involved in crosslinking actin filaments with plasma membranes." [InterPro:IPR011259]		 enablesGO:0008092 cytoskeletal protein binding PIRSF:PIRSF002305
PR:000036589 hEZR/iso:1/Phos:2
UniProtKB:P15311-1, Ser-66, MOD:00046
"An ezrin isoform 1 phosphorylated 2 in human. UniProtKB:P15311-1, Ser-66, MOD:00046." [PMID:12840026, PMID:16438931, PRO:CNA]		 enablesGO:0005515 protein binding with PR:000002696 WWOX/iso:1/UnMod PMID:16438931
PR:000036590 hEZR/iso:1/Phos:3
UniProtKB:P15311-1, Tyr-191, MOD:00048
"An ezrin isoform 1 phosphorylated 3 in human. UniProtKB:P15311-1, Tyr-191, MOD:00048." [PMID:15647376, PRO:CNA]		 enablesGO:0005515 protein binding with PR:P00523-1 PMID:15647376
PR:000036592 hEZR/iso:1/Phos:5
UniProtKB:P15311-1, Thr-567, MOD:00047
"An ezrin isoform 1 phosphorylated 5 in human. UniProtKB:P15311-1, Thr-567, MOD:00047." [PMID:16144865, PMID:18025306, PRO:AL, PRO:CNA]		 acts_upstream_of_or_withinGO:0001771 immunological synapse formation PMID:18025306
GO:0051279 regulation of release of sequestered calcium ion into cytosol PMID:18025306
enablesGO:0005515 protein binding with PR:P43403 70 kDa zeta-chain associated protein (human) PMID:18025306
located_inGO:0001772 immunological synapse PMID:18025306
GO:0045177 apical part of cell PMID:16144865
PR:000036621 hMSN/iso:1/Phos:1
UniProtKB:P26038-1, Thr-558, MOD:00047
"A moesin isoform 1 phosphorylated 1 in human. UniProtKB:P26038-1, Thr-558, MOD:00047." [PMID:18025306, PRO:AL]		 acts_upstream_of_or_withinGO:0001771 immunological synapse formation PMID:18025306
enablesGO:0005515 protein binding with PR:P16150 CD43 PMID:18025306
located_inGO:0005938 cell cortex PMID:18025306
PR:000036625 hEZR/iso:1/Phos:6
UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047
"An ezrin isoform 1 phosphorylated 6 in human. UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047." [PMID:18852256, PRO:AL]		 enablesGO:0003779 actin binding PMID:18852256
located_inGO:0002102 podosome PMID:18852256
GO:0005886 plasma membrane PMID:18852256
PR:P35240-1 hNF2/iso:1

"A merlin isoform 1 that is encoded in the genome of human." [PMID:9430655, PRO:CNA]		 enablesGO:0005515 protein binding with PR:O14745 EBP50 (human) PMID:15467741
GO:0005515 protein binding with PR:Q9H204 EG1 PMID:15467741
located_inGO:0005634 nucleus PMID:20178741
PR:P35240-3 hNF2/iso:2
merlin isoform II (human)
"A merlin isoform 2 that is encoded in the genome of human." [PMID:15467741, PRO:CNA]		 enablesGO:0005515 protein binding with PR:Q9H204 EG1 PMID:15467741
PR:P35240-4 hNF2/iso:4
merlin delE2/3 (human)
"A merlin isoform 4 that is encoded in the genome of human." [PMID:10669747, PRO:CNA]		 enablesGO:0005515 protein binding with PR:P0DPB3-1 PMID:10669747