back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - cftr isoform 1
PR:000001045 - http://purl.obolibrary.org/obo/PR_000001045
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001045   
  PRO namecftr isoform 1 
  Synonyms
PRO-Short-label: EXACT:CFTR/iso:1
Other: EXACT:cystic fibrosis transmembrane conductance regulator isoform 1
  Definition"A cystic fibrosis transmembrane conductance regulator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13569-1 or a 1:1 ortholog thereof." [PMID:9922375, PRO:CNA, PRO:DAN] 
  CommentNote: This isoform contains an intracellular regulatory domain (R-domain) that, when unphosphorylated, inhibits CFTR. Phosphorylation of the R-domain removes this inhibition, allowing activation of chloride flux. 
  PRO Categorysequence 
  ParentPR:000001044 cystic fibrosis transmembrane conductance regulator
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 3                                        
         Modification5                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000001045 cftr isoform 1, CFTR/iso:1

organism-sequence


PR:P13569-1 cystic fibrosis transmembrane conductance regulator isoform 1 (human), hCFTR/iso:1

organism-modification


PR:000036593 cftr isoform 1 N-glycosylated 1 (human), hCFTR/iso:1/NGlyco:1

organism-modification


PR:000036594 cftr isoform 1 phosphorylated 1 (human), hCFTR/iso:1/Phos:1
Yes
organism-modification


PR:000036595 cftr isoform 1 phosphorylated 2 (human), hCFTR/iso:1/Phos:2

organism-sequence


PR:P26361-1 cystic fibrosis transmembrane conductance regulator isoform 1 (mouse), mCFTR/iso:1

organism-sequence


PR:P34158-1 cystic fibrosis transmembrane conductance regulator isoform 1 (rat), rCFTR/iso:1

modification


PR:000001048 cftr isoform 1 glycosylated form, CFTR/iso:1/GlycoRes+

modification


PR:000001049 cftr isoform 1 N-glycosylated 1, CFTR/iso:1/NGlyco:1

organism-modification


PR:000036593 cftr isoform 1 N-glycosylated 1 (human), hCFTR/iso:1/NGlyco:1

modification


PR:000001050 cftr isoform 1 phosphorylated form, CFTR/iso:1/PhosRes+

modification


PR:000001051 cftr isoform 1 phosphorylated 1, CFTR/iso:1/Phos:1

organism-modification


PR:000036594 cftr isoform 1 phosphorylated 1 (human), hCFTR/iso:1/Phos:1
Yes
modification


PR:000001052 cftr isoform 1 phosphorylated 2, CFTR/iso:1/Phos:2

organism-modification


PR:000036595 cftr isoform 1 phosphorylated 2 (human), hCFTR/iso:1/Phos:2

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036594 hCFTR/iso:1/Phos:1
UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046
"A cftr isoform 1 phosphorylated 1 in human. Example: UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PMID:14602047, PMID:1716180, PRO:CNA]		 enablesGO:0005260 intracellularly ATP-gated chloride channel activity PMID:1716180
GO:0005260 intracellularly ATP-gated chloride channel activity PMID:1716180