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Protein Ontology report - interleukin-1 receptor antagonist protein
PR:000001137 - http://purl.obolibrary.org/obo/PR_000001137
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001137   
  PRO nameinterleukin-1 receptor antagonist protein 
  Synonyms
PRO-Short-label: EXACT:IL1RN
Gene-based: RELATED:IL1F3 | IL1RA
Other: EXACT:anakinra | ICIL-1RA | IL-1ra | IL-1RN | IL1 inhibitor | IRAP
  Definition"A protein that is a translation product of the human IL1RN gene or a 1:1 ortholog thereof." [PRO:CNA] 
  CommentNote: The active form inhibits the activity of IL-1 by binding to its receptor. 
  PRO Categorygene 
  ParentPR:000000001
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence4                                                  Organism-Sequence 6                                        
         Modification3                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001137 interleukin-1 receptor antagonist protein, IL1RN

organism-gene


PR:P18510 interleukin-1 receptor antagonist protein (human), hIL1RN

organism-sequence


PR:P18510-1 interleukin-1 receptor antagonist protein isoform 1 (human), hIL1RN/iso:1

organism-modification


PR:000036601 interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form (human), hIL1RN/iso:1/SigPep-
Yes
organism-sequence


PR:P18510-2 interleukin-1 receptor antagonist protein isoform 2 (human), hIL1RN/iso:2
Yes
organism-sequence


PR:P18510-3 interleukin-1 receptor antagonist protein isoform 3 (human), hIL1RN/iso:3
Yes
organism-sequence


PR:P18510-4 interleukin-1 receptor antagonist protein isoform 4 (human), hIL1RN/iso:4
Yes
organism-gene


PR:P25085 interleukin-1 receptor antagonist protein (mouse), mIL1RN

organism-sequence


PR:P25085-1 interleukin-1 receptor antagonist protein isoform 1 (mouse), mIL1RN/iso:1

organism-sequence


PR:P25085-2 interleukin-1 receptor antagonist protein isoform 2 (mouse), mIL1RN/iso:2
Yes
organism-gene


PR:P25086 interleukin-1 receptor antagonist protein (rat), rIL1RN

sequence


PR:000001228 interleukin-1 receptor antagonist protein isoform 1, IL1RN/iso:1

organism-sequence


PR:P18510-1 interleukin-1 receptor antagonist protein isoform 1 (human), hIL1RN/iso:1

organism-modification


PR:000036601 interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form (human), hIL1RN/iso:1/SigPep-
Yes
organism-sequence


PR:P25085-1 interleukin-1 receptor antagonist protein isoform 1 (mouse), mIL1RN/iso:1

modification


PR:000001271 interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form, IL1RN/iso:1/SigPep-

organism-modification


PR:000036601 interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form (human), hIL1RN/iso:1/SigPep-
Yes
sequence


PR:000001229 interleukin-1 receptor antagonist protein isoform 2, IL1RN/iso:2

organism-sequence


PR:P18510-2 interleukin-1 receptor antagonist protein isoform 2 (human), hIL1RN/iso:2
Yes
organism-sequence


PR:P25085-2 interleukin-1 receptor antagonist protein isoform 2 (mouse), mIL1RN/iso:2
Yes
sequence


PR:000001230 interleukin-1 receptor antagonist protein isoform 3, IL1RN/iso:3

organism-sequence


PR:P18510-3 interleukin-1 receptor antagonist protein isoform 3 (human), hIL1RN/iso:3
Yes
sequence


PR:000001231 interleukin-1 receptor antagonist protein isoform 4, IL1RN/iso:4

organism-sequence


PR:P18510-4 interleukin-1 receptor antagonist protein isoform 4 (human), hIL1RN/iso:4
Yes
modification


PR:000018347 interleukin-1 receptor antagonist protein, signal peptide removed form, IL1RN/SigPep-

modification


PR:000001271 interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form, IL1RN/iso:1/SigPep-

organism-modification


PR:000036601 interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form (human), hIL1RN/iso:1/SigPep-
Yes
modification


PR:000025427 interleukin-1 receptor antagonist protein proteolytic cleavage product, IL1RN/ClvPrd

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036601
hIL1RN/iso:1/SigPep-
UniProtKB:P18510-1, 26-177 | PRO_0000015328		 enablesGO:0045352 interleukin-1 type I receptor antagonist activity PMID:2139180
located_inGO:0005615 extracellular space PMID:2139180
PR:P18510-2
hIL1RN/iso:2
interleukin-1 receptor antagonist protein isoform icIL-1ra (human)		 located_inGO:0005615 extracellular space PMID:16564702
GO:0005622 intracellular anatomical structure PMID:1827201
PR:P18510-3
hIL1RN/iso:3
interleukin-1 receptor antagonist protein isoform icIL-1ra type II (human)		 located_inGO:0005622 intracellular anatomical structure PMID:7629520
PR:P18510-4
hIL1RN/iso:4
 located_inGO:0005622 intracellular anatomical structure PMID:12671514
PR:P25085-2
mIL1RN/iso:2
 located_inGO:0005615 extracellular space PMID:1524071